Kornimate/medical-research-clean huggingface dataset:
vitamin d levels in adolescent idiopathic scoliosis

Conditions: Scoliosis Idiopathic; Vitamin D Deficiency; BMD

Summary: this study aims to estimate the prevalence of vitamin d insufficiency among patients with adolescent idiopathic scoliosis, to calculate the differences in serum vitamin d levels, cobb angles, spinal bone mass densities, and serum alkaline phosphatase levels between genders in the sample, and to assess the possibility of a correlation between any of these factors in those surgical patients.

adolescent idiopathic scoliosis (ais) is a major public health problem and despite its relative rareness, it reduces the quality of life. it is three-dimensional deformity where there is a lateral curving of the spine. the prevalence rate is 0.47-5.2%. the degree of the spinal curvature is evaluated by the cobb angle. a cobb angle of more than 10-15° is considered pathological. ais occurs mostly in adolescents between 10 and 25 years of age, and is more prevalent among females. scoliosis is considered severe and requires surgical intervention when the cobb angle exceeds 40o. the etiology of ais is still unknown. genetic and non-genetic factors have been attributed to cause ais. among non-genetic factors is bone mineral density (bmd), as bone quality plays an important role in the derangement of bony mechanical stability. the prevalence of ais with osteoporosis is approximately 20-38%. osteoporosis is known to lower the bone strength. vitamin d plays an essential role in maintaining a healthy mineralized skeleton. it helps with calcium absorption, and patients with a deficiency of vitamin d can have difficulties in producing new bone and maintaining their bone strength. in this study, the prevalence of vitamin d insufficiency among patients with ais was evaluated. gender differences in serum vitamin d levels, cobb angles, bmd, and serum alkaline phosphatase levels were measured. further correlation of vitamin d with cobb angles, bmd, and serum alp levels was also evaluated.

Eligibility criteria:
inclusion criteria: * ais patients of either gender * aged between 10-25 years old * had cobb angles of 40o or more (i.e. requiring corrective surgery) * had their serum vitamin d levels measured prior to their corrective surgery. exclusion criteria: * patients with non-idiopathic scoliosis (such as congenital or neuromuscular condition) * younger than 10 years * older than 25 years of age * who did not have their serum vitamin d levels present on the system.

Keywords: vitamin d cobb angle alkaline phosphatase
analysis of changes in eating habits on post bariatric surgery patients and their family members

Conditions: Obesity; Bariatric Surgery

Summary: the main objective of this study is to identify changes in eating behaviors and physical activity in patients after bariatric surgery and their family members living in same household: children aged between 11-17 years, spouse, parents, cohabitee or partner in a civil union.

as secondary objectives, the study aims to: * describe the sociodemographic and clinical characteristics of post bariatric surgery patients. * assess changes in quality of life of the post-surgery patients. * explain changes of post-surgery in eating behavior and activity varied according to gender * explain changes of post-surgery in eating behavior and activity varied according to socio-economic conditions * explain changes of post-surgery in eating behavior and activity varied according to inter-generational relation * have a overview on the surgery as a turning point in the life of patients * estimate the relevant message of cares given to patients, in order to better adjust medical intervention, in conjunction with patients and their family members. this is a prospective observational study. it will be performed in two university hospitals: chu ambroise paré at boulogne-billancourt city and chu pitié salpétrière at paris, in nutrition department and metabolic surgery department. the study will involve collaboration of a team of social researchers.

Eligibility criteria:
inclusion criteria: * aged ≥ 18 years * eligible to undergo bariatric surgery * post bariatric surgery follow-up visits will take place in the nutrition department * living together with family member (children aged 11-17 years, parents, spouse, cohabitee or partner in civil union) * informed consent signed exclusion criteria: * higher-order cognitive disorders * language difficulties in understanding * living alone or living without any family member

Keywords: obesity bariatric surgery physical activity eating habits
elimination of ptv margins based on online adaptive stereotactic radiotherapy for centrally located early-stage non-small cell lung cancer

Conditions: Lung Cancer (NSCLC)

Summary: this study aims to explore the safety and efficacy of eliminating the ptv (planning target volume) margins based on online adaptive stereotactic radiotherapy for patients with centrally located early-stage non-small cell lung cancer (nsclc).


Eligibility criteria:
inclusion criteria: * histologically confirmed untreated early-stage non-small cell lung cancer (t1-2n0m0), or recurrent disease (rt1-2n0m0) that is inoperable or where the patient is unwilling to undergo surgery. * centrally located lung cancer. * age 18 years or older, regardless of gender. * ecog performance status score of 0-2. * serum hemoglobin ≥ 80 g/l, platelets ≥ 100,000/μl, absolute neutrophil count ≥ 1,500/μl. * serum creatinine ≤ 1.25 times the upper normal limit (unl) or creatinine clearance ≥ 60 ml/min. * serum bilirubin ≤ 1.5 times unl, ast (sgot) and alt (sgpt) ≤ 2.5 times unl, alkaline phosphatase ≤ 5 times unl. * fev1 ≥ 0.5 l. * normal cb6 range. * the patient and their family agree and sign the informed consent form. exclusion criteria: * any other disease or condition that contraindicates radiotherapy (e.g., active infections, within 6 months post-myocardial infarction, symptomatic heart disease including unstable angina, congestive heart failure, or uncontrolled arrhythmias). * pregnant or breastfeeding women, women who have not undergone pregnancy testing, and pregnant individuals. * individuals with substance abuse issues, chronic alcoholism, or aids. * individuals with uncontrollable seizures or loss of self-control due to psychiatric disorders. * individuals with a history of severe allergies or specific sensitivities.

Keywords: lung cancer radiotherapy early stage
icu biobank: understanding post-intensive care syndrome (pics)

Conditions: Post-Intensive Care Syndrome (PICS)

Summary: the goal of this observational study is to explore the development and progression of post-intensive care syndrome (pics) in adult icu patients by establishing a biobank of biological samples and outcome data. this biobank-based research is designed to investigate the physical, cognitive, and psychological health outcomes of icu survivors and their relationship with potential biomarkers. the study population includes adult icu patients aged 18-65, who have stayed in the icu for at least 48 hours. the main questions it aims to answer are: what is the incidence of pics and its main components? what risk factors are associated with the development of pics six months post-icu discharge? what are the long-term effects of icu admission on quality of life, cognitive health, and physical function? participants will: provide blood samples during icu admission and at follow-up visits at 4-5 weeks, 6 months, and 10-12 months after discharge. complete assessments measuring quality of life, cognitive health, anxiety, depression, ptsd symptoms, physical function, and pulmonary function. participate in three follow-up visits at the icu recovery clinic after discharge to monitor pics symptoms and recovery progress. this study does not involve an intervention but will gather data that could improve our understanding of pics and inform strategies for post-icu care. the data collected will be crucial for identifying pics biomarkers and will contribute to developing targeted, personalized interventions for icu survivors in the future.


Eligibility criteria:
inclusion criteria: * icu stay of at least 48 hours * age between 18 and 65 years at the time of icu admission * written informed consent exclusion criteria: * transfer from another icu outside of the medical university of vienna * patient with a legal guardian * homelessness * place of residence outside of austria

Keywords: post-intensive care syndrome (pics) icu biobank long-term icu outcomes cognitive impairment physical impairment psychological impairment health-related quality of life (hrqol) epigenetics in critical care icu recovery clinic
chemoradiotherapy with targeted immunotherapy in pediatric lymphoma

Conditions: Non-hodgkin Lymphoma; Hodgkin Lymphoma

Summary: the addition of targeted immunotherapy will be safe and well tolerated and facilitate the reduction of anthracycline exposure while preserving lymphoma disease control in children, adolescents and young adults (caya) with mature b-cell non-hodgkin lymphoma (mb-nhl) and classical hodgkin lymphoma (chl).

the primary objective is 1) to determine feasibility and safety, as defined by dose limiting toxicities (dlts), of adding polatuzumab vedotin (pv) in combination with rituximab (rtx) containing french-american-british (fab) chemoimmunotherapy, with reduced dose anthracycline, in caya with intermediate and high risk newly diagnosed mb-nhl; 2) to define the feasibility and safety, as defined by dlts, of the addition of nivolumab to the backbone of reduced toxicity chemoimmunotherapy with brentuximab vedotin (bv), vinblastine, dacarbazine and rituximab, with reduced dose anthracycline, in caya with newly diagnosed intermediate and high risk chl.

Eligibility criteria:
inclusion criteria: * newly diagnosed patients with histologically or cytologically proven newly diagnosed mb-nhl or chl according to who classification who meet the following criteria are eligible: cohort i: burkitt lymphoma (icd-o 9687/3) burkitt-like lymphoma with 11q aberration (icd-o 9687/3) diffuse large b-cell lymphoma, nos (icd-o 9680/3) high grade b-cell lymphoma (icd-o 9680/3) cohort ia: stage iii with ldh ≥ 2 uln or stage iv (5-24% bone marrow lymphoma infiltration) (group b)61 cohort ib: any cns involvement and/or bm involvement (≥ 25% lymphoma cells) (group c)61 or patients with less than 20% tumor size reduction post chemotherapy with cyclophosphamide, dexamethasone, vincristine (doc reduction for cohort ia). cohort ii classical hodgkin lymphoma (icd-o 9650/3, 9663/3, 9651/3, 9652/3, 9653/3) cohort iia: stage i-iia with bulky ± e, i-iib no bulky ± e, iiia ± e (intermediate risk) cohort iib: stage iib with bulky ± e, iiia with bulky ± e, iiib, iv (high risk) * adequate organ function exclusion criteria: * primary mediastinal b-cell lymphoma (pmbl) * t-cell/histiocyte-rich large b-cell lymphoma * gray zone lymphoma * follicular lymphoma * nodular lymphocyte-predominant hodgkin lymphoma (nlphl) * posttransplant lymphoproliferative lymphoma (ptld)
effect of preoperative oral pregabalin versus intraoperative fentanyl on postoperative analgesia

Conditions: Post Operative Pain, Acute

Summary: pregabalin is a structural analogue of gamma amino butyric acid (gaba). it binds to presynaptic alpha-2-delta subunit of voltage gated calcium channels in the brain and the spinal cord. thus, it modulates the release of excitatory neurotransmitters, such as glutamate, norepinephrine, substance-p, and calcitonin gene related peptide. also, it causes inhibitory modulation of overexcited neurons and restores them to a normal state. pre-emptive analgesia aims to reduce postoperative opioid consumption especially in ambulatory surgeries. pregabalin (pgb) is an emerging drug in this field. different doses of preoperative oral pregabalin (75, 150 and 300 mg) are described in the literature with a dose-response analgesic relationship and reduction of opioid use; however increasing the dose results in increasing the incidence of side effects mainly sedation and dizziness. perioperative use of opioids for analgesia may result in side effects; like nausea, vomiting, excessive sedation, respiratory depression, pruritus, and urinary retention.the concomitant use of opioids with pregabalin may result in excess sedation and somnolence, so, the use of opioids with pregabalin should be limited to patients with inadequate alternative options.

our study aims to compare the postoperative analgesic effect of pre-operative oral pregabalin (study group), to the intraoperative intravenous fentanyl (control group) in diagnostic laparoscopic gynecologic surgery. patienrs will be selected by simple randomization by computer generated system. pregabalin 150 mg oral capsule and a placebo capsule will be available on the morning of operation. also, 2 syringes of 10 ml volumes will be prepared; the first contains normal saline and the second contains the fentanyl dose of 1 µg /kg calculated according to the patient's body weight and diluted to a 10 ml volume. patients will then be divided into 2 equal groups of 40 patients each: group p: patients will receive oral pregabalin capsule (150 mg) 90 min before induction of anesthesia, and will receive a bolus injection of 10 ml saline at induction of anesthesia. group f: patients will receive oral placebo capsule identical to the trial drug in size, shape and color, 90 min before induction of anesthesia and will receive a bolus injection of 10 ml of 1µg /kg fentanyl at induction of anesthesia.

Eligibility criteria:
inclusion criteria: * asa physical status i exclusion criteria: * patients' refusal * use of sedatives, hypnotics, anti-psychotic or antidepressant drugs * history of drug/alcohol abuse * history of chronic pain * daily intake of analgesics * history of epilepsy

Keywords: pregabalin analgesia
mako total knee artroplasty

Conditions: Osteoarthritis, Knee

Summary: the purpose of this study is to determine the early clinical and radiographic outcomes of robotically assisted total knee arthroplasty with the mako surgical robot using the triathlon knee system. results of this study will be compared to those of a previously published cohort of patients from this institution who underwent tka using non-robotic, manual instruments. mako tka patients will be given fitbits and the focus motion knee brace to capture the data listed in attachment section. the results of this data will be compared to the control group to see if there is or there is not a difference in clinical outcomes with patients receiving total knee surgery using the mako surgical robot versus those who got total knee surgery without the mako robot.

research objectives: the purpose of this study is to determine the early clinical and radiographic outcomes of robotically assisted total knee arthroplasty with the mako surgical robot using the triathlon knee system. mean weekly vas pain score during the first 4 weeks is the primary end point. results of this study will be compared to prospective cohort of patients in the irb study 201805014 from this institution who underwent tka using non-robotic, manual instruments primary hypothesis: patients receiving robotic tka will have better early recovery, including lower mean weekly vas pain score for the first 4 weeks postoperatively and higher functional outcome scores, than the manual tka historical cohort. secondary hypothesis: patients receiving robotic tka will have more accurate component position and alignment than the manual tka historical cohort. potential contribution: this study would give us a better understanding of the clinical and radiographic outcomes of patients receiving robotic tka versus manual tka. it will identify potential advantages and disadvantages of robotic tka using the mako surgical robot.

Eligibility criteria:
inclusion criteria: * planning to undergo unilateral primary total knee arthroplasty * 18 and up * willing to sign informed consent * willing to return for all follow-up visits * smartphone or tablet device capable of running the fitbit andfocusmotion platform exclusion criteria: * bmi \> 45 * inflammatory arthritis * narcotic use greater than 5 days per week * walking aid for musculoskeletal or neurologic issue other than operative joint * bilateral total knee arthroplasty * patient with an active infection or suspected infection in the operative joint * the absolute and relative contraindications stated in the fda cleared labeling for the device
the genetics of diabetes in southern california chinese americans

Conditions: Type 1 Diabetes; Type 2 Diabetes; Metabolic Syndrome

Summary: the purpose of this research study is to investigate the genetic causes of diabetes. specifically, we are interested in the mitochondrial genome and how variants in the mitochondrial genome influence a person's risk to develop diabetes and metabolic syndrome.

since our laboratory's initial linkage of type 2 diabetes to a mtdna rearrangement in a three generation maternal pedigree 13 years ago, there has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of type 2 diabetes mellitus (dm) and the overlapping metabolic syndrome (ms). with this study we are planning an extensive investigation of defects in mitochondrial oxidative phosphorylation (oxphos) caused potentially by deleterious sequence variants in the mitochondrial dna (mtdna). as the primary objective we are trying to further substantiate 2 hypotheses: 1) that these diabetogenic mtdna variants, which are proposed to range from recent, relatively severe, mutations will result in substantial oxphos defects with familial dm \& ms and 2) that ancient, relatively mild polymorphisms result in partial oxphos defects and an increase in the risk to develop dm \& ms.

Eligibility criteria:
inclusion criteria: * chinese or taiwanese ancestry * resident of southern california * age between 40 and 65 * both people with and without diabetes are welcome to enroll. exclusion criteria: * younger than 40 years or older than 65 years * ancestry is not chinese or taiwanese * not a resident of southern california

Keywords: diabetes type 1 type 2 metabolic syndrome mitochondria
implementation and evaluation of a before school physical activity program in revere, ma

Conditions: Overweight and Obesity; Physical Activity; Quality of Life; Fitness; Executive Function

Summary: this study evaluates the implementation of the boks program in three schools (k-8) in revere, ma, and its effect on participating students with regard to bmi, cognitive, and quality of life outcomes. boks (build our kids' success) is a before-school physical activity program that has been implemented in over 2,000 elementary and middle schools. two sessions will be held (spring 2018 and winter 2018. this is a cohort study evaluating the impact of program participation on child bmi, quality of life, and executive function.


Eligibility criteria:
inclusion criteria: * enrolled in the boks program * participating school * age 5-14 exclusion criteria: * no valid consent * not enrolled in boks
effect of graston technique versus met on improving hamstring flexibility and adls in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the objective of this study is to determine the comparison of graston technique versus muscle energy technique to improve hamstring flexibility and adl among patient of knee o.a.


Eligibility criteria:
inclusion criteria: * knee osteoarthritis patient with bilateral (but tested only severe side) or unilateral limb involvement.(13) * knee osteoarthritis patient already diagnosed by orthopedic surgeon with x ray findings showing grade i or ii in kellgren and lawrence criteria for knee oa will be selected. (16) * ambulate independently with or without assistive devices and ascend and descend at least a flight of stairs.(13) * both male and female will be included in study. * age above 40 to 55years.(13) exclusion criteria: * patient with history of any known neurological, cardio or respiratory conditions. * patient present with history of open wound, skin infection or tumors in the area of treatment. * any other orthopedic condition or fracture in the area of treatment limb. * patient will be excluded if they have low back pain, sciatica or deformities related to his spine and knee. * patient with history of recent lower limb or spinal surgeries.
pilot study of anti-oxidant supplementation with n-acetyl cysteine in stage 0/i breast cancer

Conditions: Stage 0/1 Breast Cancer; Post Biopsy; Pre-surgery

Summary: nac is the n-acetyl derivative of the naturally occurring amino acid, l-cysteine. it is a common over-the-counter supplement and also is available as an injectable pharmaceutical that protects the liver in cases of acetaminophen overdose. in the exercise physiology literature, both oral and injectable nac have been shown to reduce fatigue and improve recovery from exertion which has interesting implications for exploring cancer-related fatigue. in terms of cancer cell biology, reactive oxygen species (ros) may play an important role in the development and progression of breast cancer


Eligibility criteria:
inclusion criteria: * demographic • females ≥18 years of age disease related * stage 0/i breast cancer by biopsy (patients may be consented and screened with suspected breast cancer, but no treatment will occur until cancer is confirmed by their biopsy). * awaiting surgery which will consist of either lumpectomy or mastectomy. * ecog performance status 0-1 laboratory * laboratory values that would not prevent the patient from receiving treatment as determined by the pi or study oncologist * serum creatinine ≤2.0 mg/dl * serum bilirubin ≤2.0 x uln * serum hgb ≥8.0 mg/dl general * competent to comprehend, sign, and date an irb-approved informed consent form * female subjects of childbearing potential have a negative pregnancy test exclusion criteria: * disease related * history or known presence of metastases * history of another primary cancer, except: * curatively treated cervical carcinoma in situ, or * curatively resected non-melanomatous skin cancer, or * other primary solid tumor curatively treated with no known active disease present and no treatment administered for ≤ 3 years prior to enrollment * other concurrent anticancer chemotherapy within 4 weeks as determined by the pi * any co-morbid disease that would increase risk of toxicity as determined by pi medications/treatments * subjects requiring chronic use of immunosuppressive agents (eg, methotrexate, cyclosporine, corticosteroids) * recent infection requiring a course of systemic anti-infectives that was completed ≤ 14 days prior to enrollment (exception can be made at the judgment of the pi for oral treatment of an uncomplicated urinary tract infection (\[uti\]) general * history of any medical or psychiatric condition or addictive disorder, or laboratory abnormality that, in the opinion of the pi, may increase the risks associated with study participation or study drug administration or may interfere with the conduct of the study or interpretation of study requirements * history of bronchospasm or severe asthma as determined by the pi * subject unwilling or unable to comply with study requirements * known positive test(s) for human immunodeficiency virus infection, hepatitis c virus, chronic active hepatitis b infection * documented history of alcohol, cocaine or intravenous drug abuse ≤ 6 months of enrollment

Keywords: integrative medicine breast cancer stage 0 stage 1