Kornimate/medical-research-clean huggingface dataset:
controlling femoral extension and derotation osteotomy in cerebral palsy with electromagnetic tracking

Conditions: Interal Rotation Gait; Crouch Gait; Cerebral Palsy; Malalignment

Summary: the study is designed to evaluate the use of electromagnetic tracking in multi plane femoral osteotomies, namely extension derotation osteotomies. the goal is to raise the precision of the surgical procedure in order to improve the outcome in short- and long term. all patients are examined with an instrumented 3d gait analysis pre- and one year postoperatively. the electromagnetic tracking system is evaluated against a base line ct or mri scan serving as reference standard pre- and postoperatively.

internal rotation crouch gait is a common deformity in patients with spastic diplegia. the treatment includes soft tissue and bony correction. especially the bony procedures e.g. femoral extension and derotation osteotomies have proven to be effective both in short term and long term evaluation. nonetheless there is still a relevant number of patients that suffer from over- or under-correction and recurrence over time. the reasons are diverse and include false measurement of the amount of extension and/or derotation in or. the study now evaluates electromagnetic tracking for femoral extension and derotation to improve these results. the patients are recruited from the outpatients department and included if they meet the criteria. a baseline rotational ct or mri scan and a 3d gait analysis are performed preoperatively. the patients are randomized into a electromagnetic tracking group or a classical goniometer group. the extension and derotation are measured with the emt system or with a classic moeltgen goniometer in the or. goal is to achieve the planned amounts of extension and derotation more accurately. the surgical procedure follows standard rules and does not need alterations because of the study. after the operation a second ct or mri scan is performed and the extension and derotation are precisely evaluated by two raters and later compared to the results of the intraoperative electromagnetic tracking system. one year postoperative a second 3d gait analysis is performed to measure and compare the functional and dynamic outcome.

Eligibility criteria:
inclusion criteria: * cerebral palsy * gmfcs level i-iii * functionally disturbing internal rotation gait * indication for femoral derotation osteotomy exclusion criteria: * no capacity of consent * inability to perform all needed types examinations * minors: inability of getting a mri rotational scan (i.e. pacemaker)
aripiprazole in children and adolescents with chronic tic disorder or tourette's disorder

Conditions: Chronic Motor or Vocal Tic Disorder; Tourette's Disorder

Summary: the purpose of this trial is to demonstrate the efficacy and safety of aripiprazole in children and adolescents aged 6\~18 years with chronic tic disorders or tourette's disorder


Eligibility criteria:
inclusion criteria: 1. patients who can provide an assent form signed by themselves and informed consent form by their legal representatives prior to performing of any study procedures. 2. male or female children and adolescents aged 6 to 18 years 3. patients who are diagnosed with chronic tic disorders(motor or phonic) or tourette's disorder according to dsm-iv(diagnostic and statistical manual of mental disorders-fourth edition)(using k-sads-pl-k (kiddle-schedule for affective disorders and schizophrenia,present and lifetime version-korean version)) and require drug therapy. 4. the total tic score of the k-ygtss (korean version of yale global tic severity scale)is more than 22 at baseline exclusion criteria: 1. patients with secondary tic symptoms accompanied by tardive tics, huntington disease, neuroacanthocytosis, mental retardation, or autism 2. patients with iq (intelligence quotient) (assessed using kedi-wisc (korean educational development institute-wechsler intelligence scale for children)) 70 and lower than 70 3. patients with a history of neuroleptic malignant syndrome 4. patients with antipsychotic or alcohol use disorder (abuse, dependence, and/or withdrawal) according to dsm-iv criteria for the past 3 months 5. patients with a history of allergy or hypersensitivity reaction to aripiprazole 6. patients with a history of resistance to treatment with antipsychotics 7. patients who have participated in another clinical study within 1 month prior to screening 8. patients who have previously taken aripiprazole or participated in a clinical study with aripiprazole

Keywords: chronic motor tic disorder chronic phonic tic disorder tourette's disorder aripiprazole abilify children adolescent
primary prevention long-term registry study in osa and hypertension. survival analysis 2010-2022

Conditions: Hypertension; OSA - Obstructive Sleep Apnea; MACE; Survival Analysis; PAP

Summary: hypertension and obstructive sleep apnea (osa) are both common conditions that independently increase the risk cardiovascular disease including atrial fibrillation, ischemic heart disease, heart failure and stroke. osa is also an independent promoter of hypertension development and poorly controlled hypertension is overrepresented in osa. finally, ht and osa share many risk factors including obesity, and several lifestyle factors. altogether, these links contribute to a high prevalence of patients with both disorders. the investigators suspect participants with ht and osa are at even higher cv risk and may get their first cv event earlier in life. comparison between ht and osa participants vs ht alone, osa alone or healthy controls has not previously been investigated in large studies. thus, the investigators aim to investigate long-term risk of major cardiovascular events (mace) or death comparing these groups in registry data between 2010-2022 in sweden. the investigators will also investigate the protecting effect of positive airway pressure (pap) on the osa related cv risk increase and how many hours/night of pap use is needed to get any protective effects.

please see attached analysis plan

Eligibility criteria:
inclusion criteria: * adult patients starting pap treatment for osa in the swedevox registry between 2010-2021 with and without hypertension. randomly selected controls with and without hypertension from the general population. exclusion criteria: * patients with manifest cardiovascular disease (stroke, ischemic heart disease, cardiac failure or atrial fibrillation at baseline). * patients with kidney failure at baseline. * patients with malignant cancer at baseline. * subjects with missing data on any of the main variables in the fitted models.

Keywords: primary cv prevention hypertension osa pap
early targeted antibiotic therapy in patients with sepsis

Conditions: Sepsis

Summary: the aim of this study is to assess the efficacy of early targeted antibiotic therapy in patients with sepsis and septic shock using the new biomarker sirtuin 1 and pcr for bacterial resistance detection. the primary outcome is change in sofa score (δsofa) which will be calculated by subtracting the final sofa score and sirtuin 1 level at 5 days from the corresponding initial value at enrollment. secondary outcomes included mortality rates, ventilator free days and length of icu stay.

* a prospective, single-center, open labeled, randomized interventional study * patients will be recruited from a private hospital in alexandria * approval will be obtained from research ethics committee of faculty of pharmacy, damanhour university * fourty eight critically ill patients, with sepsis and septic shock according to the 2016 third international consensus definitions, will be included * patients with risk for carbapenemase producing organisms: * use of broad spectrum cephalosporins and/or carbapenems within the past three months * polytrauma * diabetes * malignancy * organ transplantation * mechanical ventilation * indwelling urinary or venous catheters * overall poor functional status or severe illness * residence in a long-term care facility(18-28). * the baseline characteristics of the patients will be collected at the time of enrollment. the collected data included age, sex, ratio of septic shock to sepsis, ratio of ventilated to non-ventilated patients, source of infection, vital signs, laboratory data, arterial blood gas (abg), apache ii score, glasgow coma scale score, and sofa scores. the level of procalcitonin (pct) and sirtuin-1 will also be measured at this time(29). * patients will be randomly allocated to antibiotic regimen guided by conventional culture technique (n=24) or targeted antibiotics therapy guided by resistance genotyping (n=24) (29, 30). * levels of sirtuin1 will be detected using elisa kits as prescribed by manufacturer. * traditional diagnostic microbiology techniques relying on the growth of organisms on appropriate culture media (control group). * qualitative multiplex pcr test will be used for rapid detection of carbapenemases genes (intervention group) * statistical tests appropriate to the study will be conducted to evaluate significance of results * results, conclusion, discussion and recommendations will be given.

Eligibility criteria:
inclusion criteria: 1. male and female patients 18 years or older 2. a definite diagnosis of sepsis or septic shock according to the definition of the 2016 sccm/esicm task force. 3. patients at risk for carbapenemase producing organisms exclusion criteria: 1. pregnant and lactating women 2. hematological disorders (e.g., leukemia, myelodysplastic syndrome, neoplastic metastases to bone marrow), 3. life-threatening diseases (e.g., malignant solid tumors), acquired immunodeficiency syndrome. 4. lethal traumatic injury 5. acute physiologic assessment and chronic health evaluation ii (apache ii) score ≥34 (due to high predicted mortality of 80%) 6. primary fungal or viral infections
the randomized controlled cocoa-appetite trial

Conditions: Obesity

Summary: the purpose of this study is to determine whether high-flavonoid cocoa can decrease appetite in humans. in addition the study is designed to test epicatechin, a compound found in cocoa and procyanidins, a class of compounds found in cocoa, for their ability to decrease appetite in humans.

the study is a four-way randomized double-blinded crossover trial with randomization balanced for beverage and lab visit order.

Eligibility criteria:
inclusion criteria: * stable-weight, as indicated by weight gain or loss of \<2% in the past 6 months; * engaging in only mild exercise\< twice a week; * moderate alcohol users, \<2 drinks/day; * willing to eat pizza. * mentally and physically healthy. exclusion criteria: * smokers regular; * frequent drinkers of coffee, tea or cola sodas, \>daily; * underweight or obese (bmi: \ 30 kg/m2); * allergies to chocolate, cocoa, green tea, coffee or pizza; * using medication; * interested in registering in the future for the course health \& nutrition sciences 2140, introduction to the u.s. health care system, that is often taught by the pi of the proposed study
comparison of nose and conventional methods in laparoscopic right colon surgery

Conditions: Surgical Incision

Summary: laparoscopic right hemicolectomy (lrh) is an accepted surgical procedure for several right sided colonic pathologies. recently the advantages of the intracorporeal ileotransversostomy over the extracorporeal anastomosis is appearing in the literature. additionally, specimen extraction through the natural orifices is an emerging method when combined with the totally laparoscopic procedures. our observations on natural orifice surgery was promising . in our daily surgical practice, investigators prefer the intracorporeal anastomosis and this study was conducted to compare the specimen extraction sites after lrh. here investigators aimed to compare the results of conventional and natural orifice specimen extractions (nose) after totally lrhs.

compare the patient-selected nose method and conventional method in laparoscopic right colon cancer surgery

Eligibility criteria:
inclusion criteria: * laparoscopic right hemicolectomy patients exclusion criteria: * no
feasibility of a combination of graded pain exposure and graded motor imagery in people with complex regional pain syndrome type 1

Conditions: Complex Regional Pain Syndrome I (CRPS I)

Summary: background: there is low quality evidence supporting the use of rehabilitation in complex regional pain syndrome (crps), despite it is the first line approach in the guidelines . graded motor imagery (gmi) may be useful to improve pain and function at mid term (6 months). graded pain exposure approaches (gpe) seem to improve pain but not function at mid term. in other type of chronic pain conditions gpe offers better outcomes than "pain contingent" (exercises avoiding pain) approaches at short term (3 months) and similar at mid term. following the recommendations of authors, we will evaluate the efficacy and safety of a combined therapy of gmi and gpe in people with crps type 1. objective: to evaluate the feasibility of a combined therapy of gpe and gmi in front of only gmi in people with crps-1 and the clinical impact on the primary outcome (severity of the disease) of the intervention. design: feasibility randomized controlled trial, single blind of evaluator, 2 parallel arms. measurement pre-intervention, post-intervention , 1 and 3 months follow-up. population: people 18 years old or above with crps type 1 diagnosed by budapest criteria and (1) without any psychological or psychiatric disease, (2) nor any neurosensorial issue that could compromise the realization of the therapy proposed (3) neither any major surgery intervention related to crps (e.g neurostimulation or sympathectomy) (4) nor minor intervention on the last 3 months (e.g. nerve blocks). outcomes: primary outcomes: complex regional pain syndrome severity scale (severity of the disease) and safety outcomes ( oedema, pain, temperature, range of motion). secondary outcomes: 5q-5d-5l (quality of life), sf-mpq (quality, intensity and location of pain), ppt (pain pressure threshold), cpm ( pain inhibition pathways), faam or quick dash (function), pcs (catastrophism), self efficacy in chronic pain questionnaire (self-efficacy), dynamometry (hand grip strength),


Eligibility criteria:
inclusion criteria: * no difficulties understanding spanish or catalan. * diagnosed according to budapest criteria. exclusion criteria: * diagnosis of psychological or psychiatric illness * having received any major invasive treatment (e.g: spinal cord implants or sympathectomy of the affected extremity). * having received any minor invasive treatment (e.g: nerves block) in the last three months. * having any neurosensorial difficulty that could compromise the execution of the therapy proposed.

Keywords: complex regional pain syndrome physiotherapy (specialty) pain management exposure therapy efficacy safety
seborrheic dermatitis: ketoconazole 2% foam versus ketoconazole 2% shampoo

Conditions: Seborrheic Dermatitis

Summary: the aims of this study are to compare the effectiveness of antifungal foam versus antifungal shampoo and determine patient compliance and satisfaction with both vehicles among african american females with dandruff practicing less than once weekly hair washing.

a wide variety of topical vehicles are available for medications that treat scalp disorders. proper vehicle selection is important when managing scalp conditions, such as seborrheic dermatitis, because the efficacy of these treatments depends largely on compliance and the amount of active ingredient delivered to the scalp. it is therefore important to prescribe vehicles that are easy to apply and cause the least amount of disruption to the patients' pre-existing hair care practices. one of the most common rate limiting hair care practices among different cultures is wash frequency. literature shows african american women are more likely to wash their hair less than once weekly versus caucasian women. we hypothesize certain vehicles, such as foam preparations which do not require hair washing, will be more efficacious in african american women with seborrheic dermatitis than shampoo preparations.

Eligibility criteria:
inclusion criteria: * african american females aged 18 to 89 years * previous diagnosis of seborrheic dermatitis of the scalp * tdss between 50 and 200 * practice less than or equal to once weekly hair washing * immunocompetent * willing to not grease or oil scalp exclusion criteria: * age below 18 years or above 89 years * medical history of psoriasis, diabetes mellitus, immunosuppression, neurologic disorders, and/or chronic disease not stabilized by medication * patients taking any oral steroids and/or antifungals within 30 days of enrollment * sensitivity to any formulation components of either ketoconazole foam or shampoo including sulfur * the use of any topical medications including over the counter products indicated for the treatment of seborrheic dermatitis within 14 days of enrollment * pregnant women, women who plan on becoming pregnant, or breastfeeding women * current use or history of using any biologic medication

Keywords: dandruff, flaky scalp
the association of gut microbiota with urinary tract infection in infants

Conditions: Urinary Tract Infections

Summary: this prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants.

the investigators hypothesize that the gut environment reflected by intestinal microbiota influences the risk of urinary tract infection. this prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants. the investigators will sequence the v3-v4 of the bacterial 16srrna genes from the feces and analyze the sequencing data by qiime2.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of febrile urinary tract infection. * infants exclusion criteria: * congenital kidney disease * congenital heart disease * other metabolic disease
efficacy and safety of gastric suctioning during neonatal resuscitation

Conditions: Respiratory Distress

Summary: the stomach of the newborn baby is often emptied soon after birth to prevent breathing problems (respiratory distress). babies born with meconium-stained amniotic fluid and those with increased secretions associated with birth by c-section are thought to be at particular risk of breathing problems during the first minutes of life. emptying the stomach by sucking out all its contents (gastric suctioning) is alleged to lessen the risk of aspiration and improve respiratory distress. this study will evaluate the usefulness of gastric suctioning during neonatal resuscitation.


Eligibility criteria:
inclusion criteria: * term infant with meconium stained amniotic fluid or born by c-section exclusion criteria: * prematurity * congenital abnormality

Keywords: meconium aspiration respiratory distress meconium stained amniotic fluid
prospective ultrafast mri radiomics for breast cancer

Conditions: Breast Cancer

Summary: the goal of this prospective study is to investigate the performance of ultrafast mri radiomics in classifying histological factors and subtypes of breast cancer compared with standard mri among radiologists with varying experience. the written informed consent was obtained from all participant. we extracted 1618 radiomic features from ultrafast and standard contrast-enhanced mri before treatment. classification of hormonal receptors, human epidermal growth factor receptor 2, and ki67 status and subtypes was evaluated using the area under the receiver-operating characteristic curve (auc) with the delong test.


Eligibility criteria:
inclusion criteria: * diagnosed with invasive breast cancer exclusion criteria: * diagnosed with other cancer
content and expectations of consultations of patients with opioid substitution treatment considered as stabilized: cross-testimonials doctors - patients (msosuistab)

Conditions: Opioid Substitution Treatment

Summary: consultations in general medical practice concerning the follow-up of the patients receiving opiate substitution treatments are not exceptional. it is nowadays agreed that addictive pathology goes far beyond the issue of product dependence, in favor of a pathology in itself. centered on problems of attachment, of framework, of trust. the implementation of the opiate substitution treatments and the lifting of the product dependence appears only as a preliminary to the background work with the patient ex-user of opiate. finally, the literature provides little information on the experience of general practitioners and their patients under opiate substitution treatments regarding follow-up consultations in the stability phase. the objective of this work is therefore to study the feelings on follow-up consultations, general practitioners and their patients under opiate substitution treatments considered stabilized.


Eligibility criteria:
inclusion criteria: * major people patients receiving opiate substitution treatments exclusion criteria: * considered unstabilized with opiate substitution treatments
diagnostic study for differentiating functional from organic diseases in patients with lower git symptoms

Conditions: Irritable Bowel Syndrome (IBS); Inflammatory Bowel Disease (IBD)

Summary: the study is intended to find a new trusted, cost-effective biomarker for differentiating irritable bowel syndrome from inflammatory bowel disease to decrease the use of unnecessary invasive methods in patients with irritable bowel syndrome

myeloperoxidase is a lysosomal protein that is released from granules of neutrophil granulocytes during inflammation. the study design relies on the fact that there is no mucosal inflammation in case of functional gastrointestinal tract (git) disorders like irritable bowel syndrome (ibs), but organic gastrointestinal conditions like inflammatory bowel diseases (ibd) has mucosal inflammation and neutrophil influx into the mucosa. the study is designed to assess myeloperoxidase levels in both conditions and assessing its reliability in differentiation between them.

Eligibility criteria:
inclusion criteria: * adults (≥18 years) presenting with chronic lower gastrointestinal symptoms, such as diarrhea, abdominal pain, or altered bowel habits, for a duration exceeding 6 weeks. * patients with no prior diagnosis of ibd or ibs. * patients willing to provide informed consent and comply with study requirements. * those without recent use of immunosuppressants or anti-inflammatory medications that could affect biomarker levels exclusion criteria: * patients with a confirmed diagnosis of ibd and currently on treatment. * those with acute gastroenteritis, infectious colitis, or positive stool cultures for pathogens. * patients diagnosed with colorectal cancer, celiac disease, or other known organic gi disorders. * recent antibiotic, nsaid, or corticosteroid use within the past 4 weeks. * pregnant or lactating women.