Kornimate/medical-research-clean huggingface dataset:
magnetic resonance elastography (mre) as a predictor of hcc recurrence after radiofrequency ablation (rfa)

Conditions: Hepatic Fibrosis; Hepatocellular Carcinoma

Summary: the purpose of this study is to determine: * the efficacy of mre score as a predictor of hcc recurrence within 2 years after rfa treatment * the efficacy of each indicator (mre score, non-invasive serum markers) compared to the gold-standard histology score predicting hepatic fibrosis

to evaluate whether mre score reflecting hepatic fibrosis can predict the recurrence of hcc within 2 years after rfa treatment * local recurrence/intrahepatic distant recurrence * multivariable analysis including several related factors to find whether mre score is an independent predictor of hcc recurrence even after adjusting other factors (etiology of liver disease, size of hcc, vessel invasion, hbsag titer, etc.) to find the efficacy of each indicator (mre score, non-invasive serum markers) compared to the gold-standard histology score predicting hepatic fibrosis.

Eligibility criteria:
inclusion criteria: * diagnosed as single hypervascular hepatocellular carcinoma initially * ajcc stage i hcc * child-pugh class a * planning radiofrequency ablation for hcc * voluntary agreement for this study exclusion criteria: * decreased kidney function (gfr \< 70 ml/min/kg) * contraindication to mri (pacemaker, defibrillator) * contrast media hypersensitivity * other primary malignancy * acute viral hepatitis * prior history of liver transplantation * thrombosis in splenic vein or portal vein * patients who were enrolled to other clinical trials within 4 weeks * other severe chronic disease or psychiatric disease * pregnant or milk-feeding women * patients with coagulopathy, high risk of bleeding for the liver biopsy * patients who disagree to participate in this study

Keywords: hepatic fibrosis magnetic resonance elastography hepatocellular carcinoma recurrence
measurement of kidney blood flow and oxygen levels by mri

Conditions: Chronic Kidney Disease

Summary: comparison of renal blood flow measurements by pah clearance and mri

the traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (pah) is given. in this study, the investigators determine the ability of mri to estimate renal blood flow. the primary hypothesis is that renal blood flow as measured by pah clearance is similar to renal blood flow as estimated by mri. the measurements by pah clearance and mri are both performed on the same day.

Eligibility criteria:
inclusion criteria: in this study, the investigators will enroll 16 men and women aged ≥ 18 years with stage ii - v chronic kidney disease (ckd). in addition, the investigators will enroll 4 subjects with a glomerular filtration rate (gfr) of greater than 60 ml/min who do not have any evidence of ckd. exclusion criteria: this study excludes those not suitable for mri or for the interventional pharmacologic procedures.

Keywords: renal blood flow regional renal blood flow mri
retrospective/prospective data collection on the ldr roic interbody fusion device with vertebridge plating

Conditions: Degenerative Disc Disease

Summary: the purpose of this combined retrospective and prospective clinical study is to examine the clinical outcomes of the roi-c® anterior cervical interbody fusion device with vertebridge® plating to treat single level degenerative disc disease between c2 and t1 in the short term, with a focus on fusion rates.


Eligibility criteria:
inclusion criteria: * subject must have degenerative disc disease (ddd) of the cervical spine with accompanying radicular symptoms at one level between c2 and t1. * the subject can have the roi-c device at only one level. * autograft must have been used with the roi-c device. * subject should have had a minimum of 6 (six) weeks of non-operative treatment prior to surgery. * subject must be at least 21 years of age at the time of surgery exclusion criteria: * no bmp was used in the interbody cage * subject was a prisoner at the time of surgery * subject was pregnant at the time of surgery * subject had an active infection or sepsis at the time of surgery

Keywords: ddd degenerative disc disease cervical spine fusion rate
the esbjerg cohort - a cross-sectional study about work ability and musculoskeletal pain in 55 to 70 years old workers

Conditions: Work Ability; Occupational Health; Physical Capacity; Occupational Exposure

Summary: the overall aim of this study is to investigate how work with physical demands affects the physical capacity, work ability, labor market affiliation, pain and self-reported health in the oldest group of workers. following research questions are to be answered: 1. how high physical work demands affects muscle strength in 55-70-year-old workers and how obesity in combination with high physical work exposure influences muscle strength, work ability, cardiac function, and self-reported health? 2. which parameters are important for work ability and how does the exposure of high physical workload affect the work ability over time in 55-70-year-old workers? 3. by exploring the underlying mechanism of pain among 55+ year old workers, how is pain associated with work ability, bmi and physical capacity?

this study is a population-based cross-sectional study conducted in the municipality esbjerg, denmark. this study wants to investigate how ergonomic exposure in relation to physical capacity has an effect on work ability and musculoskeletal pain in workers between 55 and 70 years old. this ph.d. is a clinical study including physical tests, questionnaires, and long-term evaluation of work ability. the study population consists of 336 citizens divided into 12 groups stratified for gender, age (\< 60 years, 60-64 years and above 64 years) and occupational group (white-collar or blue-collar worker). the study population will be recruited to uncover the physical workload among citizens 55+ years and compare the physical work demands to their health status, pain and physical capacity. the intention is to provide knowledge of the consequences of high physical workload on the musculoskeletal system in the oldest group of workers. this knowledge is necessary for better treatment and counseling to the oldest group of workers and for improved guidelines on how to optimize the balance between the physical work demands and the capacity of the workers.

Eligibility criteria:
inclusion criteria: * men and women born between 1952 and 1966 * living in the esbjerg municipality * able to write, read and understand danish exclusion criteria: * injuries to arms or legs (e.g arm in plaster, acute trauma on acl) * just had a surgery (e.g an operation in the abdominal region or in the brain)

Keywords: work ability senior workers physical capacity musculoskeletal pain
the effects of preconditioning on intramuscular high-energy phosphate levels during ischemia

Conditions: Ischemia

Summary: ischemia reperfusion injury may be reduced by ischemic preconditioning. this projects aims to show the effects of short and long time ischemic preconditioning (both sequences 3 x 5 minutes) during and after an ischemic period of 20 minutes in healthy subjects by functional mri. ischemia is produces by cuff inflation to a suprasystolic pressure on one tight. signal is acquired from calf muscles. a cross-over design of 4 to 8 study periods is used, 4 different study days with 2 different mr measurement methods (bold imaging and high energy phosphates) are planned.


Eligibility criteria:
inclusion criteria: * men aged between 18 and 45 years * nonsmoker for more than 3 months * body mass index between 18 and 25 kg/m2 * normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant exclusion criteria: * regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study * evidence of hypertension, pathologic hyperglycemia, hyperlipidemia * treatment in the previous 3 weeks with any drug including over-the-counter drugs * symptoms of a clinically relevant illness in the 2 weeks before the first study day * blood donation during the previous 3 weeks * any metallic, electric, electronic or magnetic device or object not removable * claustrophobia

Keywords: ischemic preconditioning functional mri bold reperfusion
study in hcv-infected patients to determine the safety, tolerability, pharmacokinetics and antiviral activity of jnj-47910382

Conditions: Chronic Hepatitis C Infection

Summary: the purpose of this study is to determine the safety, tolerability, pharmacokinetics (what the body does to the medication) and antiviral activity of jnj-47910382 when administered in different dosing regimens in caucasian genotype-1 chronic hcv-infected patients.

this is a phase ib, double-blind (neither physician nor patient knows the treatment that the patient receives), randomized (the study drug is assigned by chance), placebo-controlled study in treatment-naïve (someone who has never used drugs for hcv infection), caucasian genotype 1 chronic hcv-infected patients. the study consists of a screening period, a 9-day treatment period (with 5 days of actual medication intake) and a 4-week follow-up period. the patients will be divided over 4 panels of 10 patients each that will be initiated sequentially. in each panel patients will receive jnj-47910382 or placebo during 5 consecutive days. jnj-47910382 or placebo will be administered once daily or twice daily. within each panel, 5 patients of genotype-1a and 5 patients of genotype-1b will be enrolled. patients will be randomly assigned to receive active treatment or placebo in such a way that 4 patients of each genotype receive active treatment and 1 subject of each genotype receives placebo. the pharmacokinetic profile of jnj-47910382 will be assessed in each panel. hcv rna kinetics (hcv rna level) and hcv resistance will be studied and biomarkers at the messenger rna (mrna), protein and cell level will be explored. the entire study duration for each participant will be approximately four weeks.

Eligibility criteria:
inclusion criteria: * chronic (diagnosis of hepatitis c more than or 6 months before the screening period) hcv infection. geno- and subtype should be determined or confirmed at screening, and should be 1a or 1b * never received (peg) ifn, rbv or any other approved or investigational antiviral treatment for chronic hcv infection * hcv rna level of \>100,000 iu/ml at screening (as assessed by standard quantitative in vitro nucleic acid amplification assay) * patients having good accessible veins exclusion criteria: * evidence of liver cirrhosis or decompensated liver disease * patient coinfected with hiv-1 or hiv-2, or hepatitis a or b virus infection, or active tuberculosis at study screening * patient infected/coinfected with non-genotype-1 hcv at study screening * patient with any cardiac disease at screening, or any active clinically significant disease, or medical history or physical examination findings during screening * patient having uncontrolled/unstable disease such as diabetes, epilepsy, a manifest psychiatric disease, thyroid disease or disorders

Keywords: chronic hepatitis c virus infection jnj-47910382 pharmacokinetics caucasian genotype-1 non-structural protein 5a (ns5a) inhibitor
effect of dosage of metformin on menstruation and lipid profile in women with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovarian syndrome (pcos) is the most common cause of anovulatory infertility and causes menstrual disruption in 6.6-6.8% of women in reproductive age and is characterized by insulin resistance, hyperinsulinemia, hyperandrogenism and anovulation. the gaol of this study was to assess the effects of metformin on menstrual disorders and lipid profile in women with pcos in bandarabbas.

poly cystic ovarian syndrome (pcos) is a common hormonal disorder in women that affecting of 6.6-6.8% of women o f reproductive age. pcos associated with a broad range of clinical, hormonal and metabolic disorders consist of hirsutism, obesity, acne and elevated male hormones, anovulatory cycles, dyslipidemia and infertility. metformin is an oral hyperglycemic agent witch by decrease insulin resistance and improving serum glucose level in diabetic patients and anovulatory cyle in women with pcos. the goal of this study is to evaluate the efficacy of different dosage of metformin on menstruation and lipid profile in women with pcos in banda-abbas.

Eligibility criteria:
inclusion criteria: * women with pcos exclusion criteria: * avoiding to participate in the study

Keywords: polycystic ovary syndrome lipid profile metformin
accuracy of 5d lb ultrasound in prediction of birth weight in macrosomic babies : a pilot study

Conditions: Macrosomia

Summary: 5d and 2d ultrasounds will be done for pregnant women with macrosomic fetuses to determine estimated fetal weight using hadlock formula. the accuracy of fetal weight obtained by ultrasound will be compared to actual birth weight.


Eligibility criteria:
inclusion criteria: * 37 to 42 weeks gestation * macrosomic fetuses * maternal diabetes exclusion criteria: * intrauterine fetal death * multiple pregnancy * congenital anomaly * nonvisualized fetal parts
trial for tobacco cessation with intensive advice in diabetic patients: the itadi project

Conditions: Diabetes Mellitus; Smoking Cessation

Summary: this study addresses an important problem in public health, smoking in diabetics. the morbidity and mortality observed in diabetics is linked to macro and microvascular problems. the consumption of tobacco has a multiplying effect on these vascular problems in diabetics. this study aims to evaluate the effectiveness of an intensive intervention in tobacco addiction in diabetic patients in primary care.

other objectives of the study are: 1. to study the effectiveness of an intensive smoking cessation intervention in the evolution of the phases of change, as based on the prochaska and diclemente model, in diabetic patients attended in primary care. 2. to evaluate the effectiveness of an intensive smoking cessation intervention in the evolution of tabacco consumption in diabetic patients attended in primary care. 3. to quantify the time spent in the intensive smoking cessation intervention compared with the usual care in primary care.

Eligibility criteria:
inclusion criteria: * diabetic patients who are active smokers * over the age of 14 * receive routine care in their respective health center exclusion criteria: * patients with communication difficulties (cognitive deterioration, language barrier) * patients who normally receive their habitual care in a different health center * patients with terminal diseases, psychiatric diseases that are unstable, or with addictions to other substances * patients that are already receiving treatment to quit smoking at the time of recruitment * patients that are difficult to locate during the study period * patients that refuse to participate in the study

Keywords: diabetes mellitus smoking cessation primary health care motivational interview
the relationship between serum endocan and adma levels and penile doppler ultrasonography in erectile dysfunction

Conditions: Evaluation of the Relationship Between Serum Biomarkers (Endocan and ADMA) and Penile Doppler Ultrasonography Findings of Patients With Severe Erectile Dysf

Summary: the gold standard diagnosis in patients admitted to the hospital with the complaint of erectile dysfunction is penile doppler ultrasonography. this procedure is an invasive procedure and can cause various complications. therefore, in this study, we aimed to support and define the diagnosis of erectile dysfunction with some biomarkers that can be measured in blood samples. at this point, we performed penile doppler ultrasonography, which is the gold standard test, for all patients who applied with the complaint of erectile dysfunction, and compared the results of penile doppler and serum biomarkers in the patients.


Eligibility criteria:
inclusion criteria: * patients with severe erectile dysfunction according to international index of erectile function-15 questionnaire * patients who have not received medical or surgical treatment before * patients without comorbidity and related drug use exclusion criteria: * patients who have had previous pelvic trauma or surgery, * patients who have benefited from using phosphodiesterase-5 enzyme inhibitors, * patients with psychogenic erectile dysfunction and moderate or mild erectile dysfunction according to international index of erectile function-15 questionnaire, * patients who have neurological disease, chronic liver disease and patients with chronic renal failure and those who used drugs that could cause erectile dysfunction

Keywords: erectile dysfunction endocan adma penile doppler
deep learning of anterior talofibular ligament: comparison of different models

Conditions: Lateral Ligament, Ankle

Summary: the purpose of this study is to study the injury of the anterior talofibular ligament by deep learning method and compare a variety of different deep learning models to establish a deep learning method that can accurately identify and grade the injury of anterior talofibular ligament, and obtain a model with better recognition and grading effect.

1. recognition and segmentation of anterior talofibular ligament based on densenet. densenet was used to recognize the axial t2-fs image, and the image level was the most typical one. the labelimg program based on python was used to locate the coordinates of the anterior talofibular ligament and then imported into python for learning. all the data were divided into a training set (70%, and then 30% of the training set was selected as the verification set). the remaining 30% was used as the test set to evaluate the accuracy of model recognition. after identifying the anterior talofibular ligament, the local clipping and amplification are carried out to remove the redundant information. finally, input the result to the next step. 2. establishment and comparison of various deep learning models: four deep learning models were established and compared in this study, namely vgg19, alexnet, capsnet, and googlenet. the models using image fitting alone and those combining with clinical physical examination data were compared for each deep learning model. the diagnostic efficiency between models was expressed by the roc curve, including auc, f1 score, etc. the roc curve was further analyzed by t-test, delong test, and other statistical methods. in this study, the data were divided into a training set (70%, 30% in the training set as the validation set), and the remaining 30% as the test set to evaluate the classification accuracy.

Eligibility criteria:
inclusion criteria: 1. without any treatment before imaging examination; 2. mr of ankle joint was performed within 3 months before operation and the image quality was good; 3. arthroscopic operation was performed in our hospital and the operation records were complete. exclusion criteria: 1. history of ankle surgery, history of cancer or previous fractures. 2. unclear image, serious artifact or incomplete clinical data.

Keywords: artificial intelligence anterior talofibular ligament sports injury
gorbly compression device for use in image-guided procedures

Conditions: Neoplasm; Sepsis

Summary: prospective cohort study. all patients presenting for percutaneous abdomino-pelvic soft tissue ablation, biopsy, or drainage performed under the care of dr. issam kably will become part of the study population. based on prior imaging and/or imaging at the time of the procedure, patients will fall into two groups, those for whom no compression is necessary to complete the procedure and those for whom compression may provide benefit. these would be selected based on dr. kably's experience as a practicing academic, fellowship-trained, and caq'ed interventional radiologist. the latter group would then further subdivide into those who give consent for use of the compression device and those who do not consent. results of each group would be measured including the following: termination versus successful completion of the procedure; adverse events including bleeding or damage to surrounding structures necessitating further medical or surgical intervention.


Eligibility criteria:
inclusion criteria: * all-comers presenting for percutaneous abdomino-pelvic soft tissue ablation, biopsy, or drainage . exclusion criteria: * open surgical or traumatic abdominal wall. * active abdominal wall infection.
indications and interest of us-guided synovial biopsies performed in clinical practice

Conditions: Arthritis

Summary: synovial biopsies are now routinely performed both in research and in clinical practice. the developments of ultrasound (us) and of us-guided needle biopsies devices have facilitated their use and tolerance by the patients. however, their interest in clinical practice in the context of an undifferentiated arthritis remains debated.

in this study, the investigators will collect all the synovial biopsies performed in clinical practice in 18 rheumatology unit throughout france. all the participants received a standardized training on us-guided synovial biopsies. for each biopsy, the indications, clinical presentation, procedure (length, tolerance), biopsy results (pathology, bacteriology, etc ...) will be collected in a clinical research form. the investigator will determine the number of cases where the synovial biopsy allows drawing a definite diagnosis.

Eligibility criteria:
inclusion criteria: all patients undergoing an us-guided synovial biopsy in clinical practice in the context of an arthritis of unknown origin exclusion criteria:

Keywords: synovial biopsy us guided synovial biopsy