Kornimate/medical-research-clean huggingface dataset:
adapted fencing in breast cancer: a pilot study

Conditions: Breast Neoplasms

Summary: literature have shown the benefit of practicing regular physical activity during and after cancer treatment, particularly in terms of improving quality of life. the french fencing federation has thus developed an adapted physical activity program (solution riposte) specially intended for patients with breast cancer. adapted fencing sessions (saber) are thus offered to these patients in a perfectly secure context (i.e. compulsory medical-sports evaluation and trained fencing master). since 2016, this riposte program has been implemented in several fencing halls in lorraine. our research project (controlled, randomized trial) aims to assess the impact of the practice of adapted fencing on the quality of life of patients, the functional capacities of the operated side (shoulder) and on the reduction of the sides effects of treatments. our hypothesis is that such an adapted fencing program improves quality of life as well as functional abilities.


Eligibility criteria:
inclusion criteria: * be a woman * ≥ 18 years old. * have undergone unilateral breast surgery for primary invasive breast cancer * time between surgery and inclusion between 2 to 4 weeks after surgery * accept and be able to complete self-administered questionnaires * satisfy the prior medico-sports evaluation * be affiliated to a social security scheme or beneficiary of such a scheme * have received full information on the organization of the research and have signed their informed consent. exclusion criteria: * presence of bone metastases, especially vertebral * presence of a contraindication to the practice of fencing during the medico-sports evaluation (post-surgery period that is too painful and / or requiring specific treatment in rehabilitation) * refusal to participate in the study * woman of childbearing age who does not have effective contraception. * persons referred to articles l.1121-5, l.1121-7 and l. 1121-8 of the public health code * pregnant woman, parturient or nursing mother * minor (non-emancipated) * adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice) * person of full age unable to express consent * persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric treatment under articles l. 3212-1 and l. 3213-1.

Keywords: breast neoplams adapted physical activity
understanding risk factors involved in developing a second blood clot.

Conditions: Deep Vein Thrombosis

Summary: the purpose of this study is to develop a way to predict which patients diagnosed with idiopathic blood clots can safely stop warfarin therapy after six months. we will use patient characteristics, blood test results and imaging test results to identify those patients who have the lowest risk of developing a new blood clot after warfarin is stopped.

the risk of recurrent vte in patients with idiopathic vte subsequent to three to six months of oral anticoagulant therapy remains high (5-27% per year). the risk of recurrent vte, however, is not likely high enough to justify indefinite anticoagulation in all patients with a first idiopathic vte due to the rate of major bleeding with oral anticoagulants (2-6% per year), the inconvenience and cost of oral anticoagulant therapy, monitoring of oral anticoagulant therapy (e.g. prescription costs, time off work to go for lab tests, parking etc) and the lifestyle limitations of oral anticoagulant therapy (avoidance of certain physical activities, dietary restrictions, avoidance of pregnancy). further, as some have argued, perhaps all that anticoagulant therapy achieves is to delay recurrent vte and, as a recent editorial suggested, a tailored approached is required to determine sub-groups who require lifelong anticoagulation. a means to stratify patients with idiopathic vte to identify a group at low risk of recurrent vte who could safely discontinue oral anticoagulants subsequent to six months of therapy would be a significant advance in the care of these patients.

Eligibility criteria:
inclusion criteria: 1. objectively proven (as previously described (8)) proximal idiopathic deep vein thrombosis or pulmonary embolism. idiopathic will be defined as vte occurring in the absence of fracture, plaster cast, immobilization greater than 3 days or a general anesthetic in the last three months prior to vte diagnosis; a known deficiency of antithrombin, protein c or protein s; and malignancy in the last five years 2. patients treated initially with a minimum of five days of heparin or low molecular weight heparin and oral anticoagulants with a target intensity of 2.0 - 3.0 with no recurrence in the subsequent six months. 3. patients currently on oral anticoagulants exclusion criteria: 1. recurrent idiopathic vte (i.e. \&#8805; 2 previous idiopathic vte). previous secondary vte is not an exclusion criterion; 2. age \&lt;18; 3. known deficiency of proteins s, protein c or antithrombin; 4. known, persistently positive anticardiolipin antibodies (titers \&gt; 30u/ml); 5. known, persistently positive lupus anticoagulant; 6. combined thrombophilic defects (e.g. homozygous for fvl or pgm, or compound heterozygous for fvl and pgm); 7. refusal of informed consent.

Keywords: recurrent idiopathic deep vein thrombosis pulmonary embolism clinical prediction rule venous thromboembolism risk factors
anxiety and pain during intervention for abortion under local anesthesia

Conditions: Abortion

Summary: the aim of the study is to retrospectively analyze pain and anxiety assessment data previously collected in routine care in women who had an abortion under local anesthesia in order to identify the predictive factors of pain and anxiety, as well as to compare the results with previously published data. the participants are women who underwent abortion under local anesthesia in the gynecology department of the pitié salpêtrière hospital between may and october 2021.

voluntary interruption of pregnancy corresponds to a social demand. the french national authority for health recommends that any woman wishing to have a surgical abortion should have the choice between general anesthesia and local anesthesia. the advantages of local anesthesia are its simplicity and safety; the disadvantages are that the state of consciousness during the procedure may be associated with anxiety, and the perception of persistent pain despite the local anesthesia. the majority of patients express pain during the procedure. anxiety may be a major predictor of pain during the procedure. moreover, beyond its possible involvement in pain, anxiety is also a factor of patient discomfort in its own right. the 10-point verbal numerical scale was used for assessing pain and anxiety. the state trait anxiety inventory (stai), a 20-item anxiety scale, is also used as a reference to measure anxiety. this scale is carried out for patients undergoing an abortion under local anesthesia in the department. other factors could have an impact on the level of pain : age, pregnancy term, parity, history of dysmenorrhea, history of domestic violence or sexual violence. the investigator team conduct a retrospective analysis in a cohort of patients who underwent an abortion under local anaesthesia in the obstetrics gynecology department of la pitié salpêtrière, analyzing their level of pain before, during and after the intervention the secondary objective is to analyze their anxiety level. age, term of pregnancy, parity, history of dysmenorrhea, history of violence will be analyzed as potential predictive factors of pain.

Eligibility criteria:
inclusion criteria: * patients who need an abortion under local anesthesia * women who speak and read french exclusion criteria: * na
stress management and biological age in breast cancer patients.rct

Conditions: Stress; Breast Cancer; Telomere Length, Mean Leukocyte

Summary: intense stress has harmful effects on the body, contributing to various disorders. breast cancer patients experience a build-up of stress due to their diagnosis and treatments. stress can cause epigenetic changes in a cellular level (such as accelerated increase in biological age) that may negatively affect oncological treatments. this study aims to investigate the effect of stress management, specifically the pythagorean self-awareness intervention, on telomere length in t-leukocytes of breast cancer patients after completing all treatments except hormonal therapy. the study involves self-referred questionnaires, hair cortisol collection, and blood material extraction. understanding the role of stress management in breast cancer may lead to improved patient outcomes and survival rates.

distress can have serious effects on the human body and is known to contribute to various disorders, including cardiovascular diseases. in the case of breast cancer, patients often experience a build-up of stressful events throughout their journey with the disease, such as diagnosis, surgery, chemotherapy, radiotherapy, survival, and dealing with side effects of anticancer therapy. many studies have shown that psychological stress is closely related to increased cortisol levels in the body. this stress may lead to epigenetic changes in telomere length, the action of telomerase, the function of t-leukocytes, and the response of pro-inflammatory cytokines, all of which play significant roles in the treatment of oncological patients. considering these factors, managing stress becomes crucial, as it can not only indirectly affect the disease's outcome but also impact survival. this scientific protocol aims to investigate the impact of a holistic stress management program on the telomere length of t-leukocytes in the peripheral blood of women diagnosed with breast cancer. the stress management technique to be employed is the pythagorean self-awareness intervention, which will be administered only after completing all cancer treatments, except for hormonal therapy. the methods that will be followed include distributing self-referred questionnaires to assess stress and lifestyle, collecting hair cortisol samples, and extracting genetic (dna) material to study the telomere length of t-cells from peripheral blood. by studying the impact of stress and its management on telomere length in breast cancer patients, this study aims to contribute to a better understanding of how stress affects health outcomes and potentially provide insights into improving patient care.

Eligibility criteria:
inclusion criteria: * diagnosis of primary breast cancer * completion of anticancer therapy (except for hormonal therapy) exclusion criteria: * psychiatric diagnosis and treatment * metastasis * previous participation in any stress management and health promotion study * inability to read or write in greek

Keywords: stress breast cancer lifestyle stress management telomeres biological age psai
breath analysis for sars-cov-2 in infected and healthy subjects

Conditions: SARS-CoV-2 Infection

Summary: recently published studies could demonstrate that detection of specific biomarkers in breath could be applied for the diagnosis of sars-cov-2.

in this study we want to address the sensitivity and specificity of breath analysis by mcc-ims in the context of sars-cov-2 detection from pcr- proven infected and non-infected subjects. therefore nasal breath will be aspirated for 10 seconds during normal respiration by a foam cuffed oxygen catheter connected via a 0.22μm filter and a line into the mcc-ims and directly analyzed without any pre-analytic procedures. the during the proof-of-concept study derived significant peaks for volatile organic compounds will be used for discrimination in a point-of-care approach.

Eligibility criteria:
inclusion criteria: hospital admission staff members exclusion criteria: too sick to comply with study procedures
predictive factors for failure of internal fixations of lower limb fractures

Conditions: Lower Limb Fractures

Summary: background: a predictive factor is a measure that predicts treatment response. decisions on internal fixations of lower limb fractures should regard predictive factors to personalize (e.g. age) treatment. however for most potentially influencing factors valid data on the predictive value is sparse. objectives: the objective of this study is to identify predictive factors and quantify their predictive ability for treatment failure in patients with limb fractures treated with osteosynthesis. methods: patients adult patients (≥18 year) with isolated fractures scheduled for urgent or semi-urgent surgery using internal fixations because of lower limb fractures. the predictive value of the following exposures will be analyzed: * age * gender * diabetes * smoking status * body mass index * open fractures * peripheral arterial disease outcome the outcome will be (time to) reoperation of the same fracture because of failure of internal fixation due to nonunion or implant failure. study design a prospective observational cohort study will be performed. sample size 300 patients will be included. statistical analysis: for the main analysis a multivariate stratified cox proportional hazard model will be used. the model will be stratified according to the indication. in the cox proportional hazard model all predictive factors will be entered simultaneously to quantify the independent influence (adjusted for all other factors) of each factor. the strength of prediction will be described with hazard rations and their corresponding 95% confidence intervals.

see study protocol: https://uni-wh.de/fileadmin/user_upload/03_g/07_humanmedizin/05_institute/ifom/iff-profak_protocol.pdf

Eligibility criteria:
inclusion criteria: adult patients (≥18 years) with isolated fractures scheduled for urgent or semi-urgent surgery using internal fixations because of the following lower limb fractures will be included: * tibia fractures * femur fractures * ankle fractures * calcaneal fractures exclusion criteria: * periprosthetic fractures * insufficient knowledge of the german language * strong cognitive impairment

Keywords: fractures, risk prediction
the effects of the dietary supplement cardioflex q10 on reducing cardiovascular disease risk factors in adults

Conditions: Cardiovascular Diseases; Cardiovascular Abnormalities; Heart Attack; Stroke; Hypertension

Summary: cardiovascular diseases (cvd), primarily heart disease and stroke, are the leading causes of death and prescription drug use in canada. research on certain dietary supplements looks promising as a way to help reduce cvd risk factors. studies show that supplementation of certain nutrients such as antioxidants, amino acids, electrolytes, vitamins and minerals may effectively reduce cardiovascular risk factors. the dietary supplement cardioflex q10, which is high in the aforementioned components, was developed to help regulate the body's production of cholesterol, strengthen the arteries and heart, and reverse oxidation. the overall objective of this study is to determine if 90 days of supplementing with cardioflex q10 can reduce cvd risk factors in adults, independent of other dietary or physical activity changes.

the purpose of this study is to determine whether or not daily supplementation with the dietary supplement cardioflex q10 for 90 days can reduce cardiovascular risk factors in healthy adults. the health markers that will be tested include the participant's waist circumference, body weight, body mass index (bmi), atherosclerosis risk factors (blood pressure, plethysmogram (ptg) wave form, heart rate variability, accelerated plethysmograph (apg) type (biological age of arteries)), and blood work including total plasma lipid profile (total cholesterol (tc), high density lipoprotein (hdl), low density lipoprotein (ldl), triglycerides (tgs)), kidney and liver function (alanine aminotransferase (alt), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), blood urea nitrogen (bun), creatinine), and inflammatory and endothelial function biomarkers (c-reactive protein (crp), interleukin-6 (il-6), soluble intercellular cell adhesion molecule-1 (sicam-1), soluble vascular cell adhesion molecule-1 (svcam-1) ). all health markers will be tested the day before starting the study and the day after the study is completed.

Eligibility criteria:
inclusion criteria: * age 30-65 * an accelerated plethysmograph (apg) type (biological age of arteries) of d, e, f or g and/or a high density lipoprotein (hdl) to total cholesterol (tc) ratio of ≤24 percent exclusion criteria: * have used prescription cholesterol or blood pressure medication in the last 3 months * perform more then 150 minutes of moderate to rigorous activity per week * pregnant or planning on getting pregnant during the study period

Keywords: dietary supplements cardiovascular diseases heart attack stroke hypertension amino acids electrolytes antioxidants
effect of zinc and selenium supplementation on hiv+ individuals on antiretroviral treatment.

Conditions: HIV; ART; Zinc Deficiency; Selenium Deficiency; Metabolic Complication; Inflammation

Summary: the aim of this study is to evaluate the effect of zinc gluconate and/or selenium yeast supplementation during six months on clinical (glucose, cholesterol, triglycerides, bone mineral density and body composition) and immunological (oxidative stress, cd4+ count and pro-inflammatory cytokines) parameters in a population with hiv diagnosis on antiretroviral treatment.

hiv-infected individuals on antiretroviral treatment have lowest risk of aids events and more life expectancy. however, antiretroviral treatment does not fully restore the immune system in all individuals due to persistent immune activation and inflammation, increasing the risk of non-aids complications, such as insulin resistance, diabetes, hypertension, dyslipidemia, obesity, low bone mass density, oxidative stress and micronutrient deficiencies. several studies showed that hiv+ patients present zinc and selenium deficiency. those micronutrients are involved in the pathogenesis of metabolic complications and have a major role in maintaining immune system function. it remains unknown the effect of zinc and selenium supplementation on metabolic and immunological parameters associated to non-aids complications.

Eligibility criteria:
inclusion criteria: * hiv infected * \>200 cd4+ cells/ml * \>2 years under antiretroviral treatment * \>2 years under virology control (hiv rna \<40 copies/ml) exclusion criteria: * patients with opportunistic infection * patients taking vitamin-mineral supplements * patients with moderate or high cardiovascular risk (framingham score higher than 10%) and cholesterol ldl \>190 mg/dl or triglycerides \>500 mg/dl. * patients with diabetes or hypertension diagnosis. * patients taking drugs for diabetes, hypertension, dyslipidemia or low bone mass density. * low adherence to supplementation.
topical sm29 in combination with meglumine antimoniate in the treatment of cutaneous leishmaniasis.

Conditions: Cutaneous Leishmaniasis, American

Summary: this project is composed of a phase i study with the purpose of evaluating adverse reactions and the best dose to be used of sm29 and a phase ii randomized controlled study with 3 arms with the purpose of comparing the efficacy of meglumine antimoniate associated with sm29, with meglumine antimoniate plus placebo and meglumine antimoniate alone in the treatment of cutaneous leishmaniasis.

the phase i study was performed in 10 healthy subjects and 10 patients with cl. in healthy individuals (n=5) sm29 was applied to healthy skin at a concentration of 5ug and in another 5 sm29 was used at a dose of 10ug applied twice a day for 20 days. a phase i study was also carried out in 10 patients with cl to assess the occurrence of adverse reactions to sm29 applied to the ulcerated lesion and to compare the use of two doses of sm29. in 5 patients, sm29 was used at a dose of 5ug and applied twice a day, and in 10 patients, a dose of 10ug of sm29 was used, also applied twice a day. the 10 patients were also treated with glucantime at a dose of 20mg/kg/weight with a maximum dose of 1200mg/day intravenously for 20 days. patients were evaluated on days 10, 20 and 30 for adverse reactions.

Eligibility criteria:
inclusion criteria: - clinical diagnosis of cutaneous leishmaniasis (typical ulcerated lesion); 1 to 2 ulcers; ulcer size ranging from 10-40mm; disease duration between 20-90 days. exclusion criteria: * diabetes; cardiovascular or kidney disease; hiv seropositivity; use of immunosupressive drugs; pregnancy.

Keywords: cutaneous leishmaniasis sm29 l. braziliensis
effectiveness of p02 digital hearing aids

Conditions: Hearing Loss, Bilateral; Sensorineural Hearing Loss

Summary: to test the effectiveness of body-worn, digital hearing aids, model 02 which is developed by the national electronics and computer technology center, thailand.

hearing aids distribution and service system are limited accessed in hearing disabled people in developing countries. the local-made, body-worn, digital hearing aids is developed by the national electronics and computer technology center, thailand. the effectiveness of this model will be compares with other standard body-worn, hearing aids in community elders. the functional gain, quality of sound, customers' satisfaction, and quality of life (eq-5d, hhie, hui-3, ioi-ha) are main outcomes.the cost of screening and hearing aids will be also investigated. the validity and reliability of several tools used such as the thai-hearing handicap inventory for elderly (hhie) questionnaire, music test, thai-five minute hearing test, and khon kaen hearing aids evaluation are also studied.

Eligibility criteria:
inclusion criteria: * older than 60 years * bilateral sensorineural hearing loss * pta (0.5-2 khz) of better ear \> 40 db but \<75 db * no deformity of pinna and ear canal * new or unexperienced hearing aids user * can communicate with thai or local language exclusion criteria: * speech discrimination \<40% * suspected of retrocochlear lesion

Keywords: hearing aids hearing disability community hearing aids service
p450 mediated lung toxicity

Conditions: Pulmonary Disease

Summary: the purpose of this project is to do cross species comparisons of the metabolism and toxicity of a number of toxicants which require metabolism for toxicity. all of the toxicants in question are encountered by humans in the workplace, through lifestyle choices (cigarette smoking) and as a result of environmental contamination. the high incidence of pulmonary diseases in the human population means that it will be difficult if not impossible to determine whether humans are at risk from exposure to these chemicals without solid mechanistic data. recent rodent bioassays suggest that these compounds have oncogenic potential further supporting the need to test the potential for injury in primates. as part of this testing, we intend to establish in vitro methods for assessing critical steps in the metabolism of these agents and their interaction with cellular macromolecules. once this is done, similar studies can be conducted in rhesus or in human lung tissue that is available because it cannot be used for transplant purposes.


Eligibility criteria:
all available organ donors in the sacramento area

Keywords: lung function smoking metabolism