Kornimate/medical-research-clean huggingface dataset:
person-centered oncology care and choices (p-cocc): piloting and initial randomized testing of a combined values narrative interview and video education advance care planning program in gastrointestinal oncology patients

Conditions: Advanced Gastrointestinal Cancer

Summary: this study is being done to get individuals' feedback on advanced care planning and decision making. this study is divided into two parts (part 1 and part 2). the purpose of part 1 is to survey people to find out what is important to people with advanced cancer (again, their values, such as their goals, concerns and sources of support). this has never been done before in the way the investigators are doing it, and that is why this is called a "pilot" study, which is where a new method or treatment is being created and evaluated. the purpose of part 2 is to see if combining a medical options video with a short interview about values helps people with how they feel about their medical situation, and what they know about their medical options for their medical situation.


Eligibility criteria:
inclusion criteria: * able to speak, read and understand english well enough to complete study assessments and interviews in the judgement of the consenting professional * 18 years of age and older * be seen regularly (at least monthly) at an mskcc gi medical oncology clinic * has an exocrine gi cancer with mskcc pathology confirmation at the primary or metastatic anatomic site * non-metastatic gi cancers are eligible only if the eastern cooperative oncology group (ecog) performance status54 is 2,3, or 4 at the time of consent (although patients with locally advanced \[stage iii\] and inoperable pancreatic cancers are eligible regardless of their performance status) * has a metastatic neuroendocrine histology with mskcc pathology confirmation as moderately or poorly differentiated or intermediate or high grade * a referring physician's estimate of patient life expectancy must be between 1-12 months. we use this life expectancy range in order to ensure some degree of subject homogeneity for the purpose of sample size and methodologic design. also, these timeframes were chosen in order to test an intervention in patients with serious illness (under 1 year prognosis). * part 2 only: did not complete part 1 of the study. exclusion criteria: * short portable mental status questionnaire (spmsq) score of less than "intact mental functioning" (3 or more errors). * significant psychiatric or cognitive disturbance sufficient, in the consenting professional's or investigator's judgment, to preclude providing informed consent or participating in the interventions (i.e., acute psychiatric symptoms which require individual treatment).

Keywords: 13-120
selonsertib in combination with prednisolone versus prednisolone alone in participants with severe alcoholic hepatitis (ah)

Conditions: Alcoholic Hepatitis (AH)

Summary: the primary objective of this study is to evaluate the safety and tolerability of selonsertib (gs-4997) in combination with prednisolone versus prednisolone alone in participants with severe alcoholic hepatitis (ah).


Eligibility criteria:
key inclusion criteria: * willing and able to give informed consent prior to any study specific procedures being performed. in individuals with hepatic encephalopathy (he) which may impair decision-making, consent will be obtained per hospital procedures (eg, by legally authorized representative) * clinical diagnosis of severe ah * maddrey's discriminant function (df) ≥ 32 at screening key exclusion criteria: * pregnant or lactating females; * other causes of liver disease including chronic hepatitis b (hepatitis b surface antigen \[hbsag\] positive), chronic hepatitis c (hcv rna positive), acetaminophen hepatotoxicity, biliary obstruction, and autoimmune liver disease; * serum aspartate aminotransferase (ast) \>400 u/l or alanine aminotransferase (alt) \>300 u/l; * model for end stage liver disease (meld) \>30 at screening; * maddrey's df \>60 at screening; * grade 4 hepatic encephalopathy (he) by west haven criteria; * concomitant or previous history of hepatocellular carcinoma; * history of liver transplantation; * hiv ab positive; * clinical suspicion of pneumonia; * uncontrolled sepsis; * uncontrolled gastrointestinal (gi) bleeding or controlled gi bleeding within 7 days of screening that was associated with shock or required transfusion of more than 3 units of blood; * type 1 hepatorenal syndrome (hrs) or renal failure defined as a serum creatinine \>221 μmol/l (\>2.5 mg/dl) or the requirement for renal replacement therapy; * individuals dependent on inotropic (eg, epinephrine or norepinephrine) or ventilatory support (ie, endotracheal intubation or positive-pressure ventilation); * portal vein thrombosis; * acute pancreatitis; * cessation of alcohol consumption for more than 2 months before baseline/ day 1 note: other protocol defined inclusion/ exclusion criteria may apply.

Keywords: cirrhosis prednisone jaundice
correlates between eeg microstates and clinical characteristics of people with stroke

Conditions: Stroke; Electroencephalogram

Summary: stroke has been considered one of the main causes of long-term disability in the adult population, and is no longer considered a disease of the elderly, since 2/3 of all strokes occur among people under 70 years of age. according to the ministry of health, stroke is responsible for 40% of early retirements, being one of the most important causes of mortality in brazil. the electroencephalogram (eeg) has been shown to be a very useful tool in the study of functional status and for the diagnosis of brain damage and disorders. it is considered a simple, non-invasive test with high temporal resolution, being a method widely used in laboratories to non-invasively monitor brain activity.

stroke has been considered one of the main causes of long-term disability in the adult population, and is no longer considered a disease of the elderly, since 2/3 of all strokes occur among people under 70 years of age. according to the ministry of health, stroke is responsible for 40% of early retirements, being one of the most important causes of mortality in brazil. stroke usually causes long-term deficits such as asymmetrical muscle weakness between limbs, impaired proprioceptive ability, sensory loss, vision problems, and spasticity. in addition, these sensorimotor deficits interfere with various functions of the lower limbs, including balance, postural control, and gait ability, affecting their quality of life. the electroencephalogram (eeg) has been shown to be a very useful tool in the study of functional status and for the diagnosis of brain damage and disorders. it is considered a simple, non-invasive test with high temporal resolution, being a method widely used in laboratories to non-invasively monitor brain activity. microstates reflect short periods (\~100 ms) of nearly stable brain states evolving over time, resulting from the synchronous and coordinated activity of brain networks. the aim of this study is to observe whether eeg microstates have correlations with clinical characteristics of people with stroke.

Eligibility criteria:
inclusion criteria: * people over 18 years of age, regardless of sex and with a stroke confirmed by computed tomography or magnetic resonance imaging. exclusion criteria: * have other associated neurological pathology
tdcs and upper extremity function in stroke

Conditions: Stroke

Summary: research on the effects of anodal transcranial direct current stimulation (tdcs) on hand dexterity and quality of life in stroke patients is limited. while the highlighted article focuses on parkinson's disease, it underscores anodal tdcs potential to modulate brain activity and promote neural plasticity, suggesting potential relevance to stroke rehabilitation

tdcs seems like a hopeful way to help stroke patients improve their upper limb function, but there are still some problems and questions that need to be answered. previous studies have investigated the impact of (tdcs) on upper limb recovery among stroke patients. however, evidence is scarce on the effect of tdcs on hand dexterity and quality of life in stroke patients. furthermore, these studies have not adequately explored how the severity of stroke influences the efficacy of tdcs on upper limb motor recovery. additionally, there is a lack of research examining the cumulative effects of tdcs on both upper limb motor recovery and hand dexterity, as well as qol, particularly concerning stroke severity.

Eligibility criteria:
inclusion criteria: * stroke for more than 6 months. * age 40-80 years * both gender * national institutes of health stroke scale (nihss) for severity level (mild (1-4), moderate (5-15), moderate to severe (16-20), severe (21-42) exclusion criteria: * any patient with upper limb amputation on the effected side, contracture, burn injury that leads to joint limitation and functional limitation. * known cases of multiple sclerosis and parkinson and any musculoskeletal disorder and cardiopulmonary disorder. * any patient with metallic implants * individuals with a history of seizures or epilepsy * individuals with skin allergies on the scalp

Keywords: stroke upper limb tdcs
clinical significance of hepatic biomarkers in lung cancer patients treated with immune checkpoint inhibitors

Conditions: Immune Checkpoint Inhibitor; Lung Cancer; Liver Biomarkers; Transaminases

Summary: lung cancer is the leading cause of cancer death worldwide. the emergence of immune checkpoint inhibitors (icis) has revolutionized the treatment of lung cancer over the past 10 years. nivolumab, ipilimumab, pembrolizumab, atezolizumab, and durvalumab have been successively approved in non-small cell lung cancer, small cell lung cancer, and pleural mesothelioma. although the efficacy of icis is remarkable in some patients, the objective response rate is only about 20%. the development of predictive biomarkers for treatment response is essential. non-invasive methods and easily accessible biomarkers at low cost are required.icis activate the immune system through the inhibition of checkpoints (pd-l1, pd-1). the immune system and the liver are interconnected and constantly interact through a complex regulatory system. patients with lung cancer frequently suffer from liver damage, due to metastases, treatments or underlying pathologies. the objective of the study is to evaluate the clinical significance of key liver biomarkers (ast, alt, pal, ggt, bilirubin, pt) in patients with lung cancer treated with ici.


Eligibility criteria:
inclusion criteria: * inclusion criteria: * age \> 18 years * patient with lung cancer of any histological type * initiation of ici therapy * signed consent for the study exclusion criteria: * patient with previous ici treatment

Keywords: immune checkpoint inhibitor lung cancer liver biomarkers transaminases
arrhythmias, microalbuminuria and corticosteroids

Conditions: Corticosteroids Adverse Reaction

Summary: the goal of this observational design is to study the effects of intravenous corticosteroids on heart rate variability, arrhythmias and microalbuminuria. some previous studies have shown that intravenous corticosteroids could induce bradycardia but also supra-ventricular tachycardia and atrial fibrillation. a second goal of this study is to investigate whether exogenous corticosteroids may induce microalbuminuria. a large retrospective study has revealed an association between microalbuminuria and corticosteroid use in the year preceding the measurement.

on intra-hospital patients, it will be explored the prevalence of arrythmias, the heart rate variability and the modification of the microalbuminuria level after intravenous infusion of corticosteroids. the investigator shall not initiate the treatment. patients will receive high-dose intravenous corticosteroids for the treatment of different diseases. the departments, where the patients are enrolled, are: nephrology, neurology, dermatology and rheumatology and the day hospital. the day before the corticosteroids administration, a holter monitor will be started for at least 24h to detect arrhythmias and heart rate variations. by mean of a finometer, beat-to-beat blood pressure, cardiac output and baroreflex sensitivity will be measured before, during and after the infusion. blood and urine samples will be used to explore the effects of corticosteroids on microalbuminuria, electrolytes, crp and glomerular filtration rate during the 3 days of observation. to our knowledge, it will be the first prospective trial to explore a link between intravenous corticosteroids administration and heart rate variability, baroreflex sensitivity, as well as microalbuminuria.

Eligibility criteria:
inclusion criteria: * starting high-dose intravenous corticotherapy exclusion criteria: * none

Keywords: corticosteroids arrhythmia heart rate variability albuminuria
impact of a childhood obesity intervention for african american families

Conditions: Obesity; Overweight

Summary: the purpose of this study is to evaluate the impact on body mass index (bmi) of a 5-session childhood obesity intervention for african american families among children aged 5-12 years. we hypothesize that children participating in the program will experience a reduction in bmi.


Eligibility criteria:
inclusion criteria: * bmi greater than or equal to the 85th percentile for age and sex * attends an elementary school in the pittsburg unified school district in california * parent of child meeting above criteria exclusion criteria: -

Keywords: schools pediatrics obesity overweight intervention studies african americans family body mass index
cardiovascular responses in adolescent idiopathic scoliosis girls

Conditions: Adolescent Idiopathic Scoliosis

Summary: the aims of this pilot study are to determine the metabolic demand and exercise intensity level of e-fit exercise intervention by evaluating the cardiovascular responses in ais girls and whether the cardiovascular responses for ais girls performing e-fit will behave in the same way as compared to healthy controls. we hypothesise that 1) the metabolic demand and exercise intensity of e-fit exercise intervention is equivalent to moderate-to-vigorous level; and 2) ais girls have different cardiovascular responses as compared to healthy controls

ais girls and age- and gender-matched healthy controls will perform the e-fit exercise intervention for two trials and gas exchange parameters including oxygen consumption (vo2) and carbon dioxide production (vco2) will be taken continuously during the exercise. comparison of vo2 and vco2 between ais and healthy controls when performing e-fit exercise will be made.

Eligibility criteria:
inclusion criteria: * cobb angle greater or equal to 15 degree * cleared for physical activity by doctor exclusion criteria: * cobb angle greater or equal to 40 degree, or * scoliosis with any known etiology, scoliosis with skeletal dysplasia, know endocrine and connective tissue abnormalities, or * known heart condition or other diseases that could affect the safety of exercise, or * eating disorders or gi malabsorption disorders, or * currently taking medication that affects bone or muscle metabolism
comparative efficacy of magnesium sulfate iontophoresis and extracorporeal shockwave therapy on chronic mechanical neck pain

Conditions: Mechanical Neck Pain

Summary: the purpose of the study is to investigate the comparative efficacy of magnesium sulfate iontophoresis and extracorporeal shockwave therapy on chronic mechanical neck pain


Eligibility criteria:
inclusion criteria: * medically competent men and women will be included * they had chronic mtrps in the upper trapezius for more than 6 months * diagnostic criteria of being a tight band with a palpable nodule and distant pain when subjected to pressure exclusion criteria: * subjects with previous neck or shoulder pathology (e.g., fracture, sur¬gery, inflammatory and infectious diseases), * cervical disc pathology, systemic disorder, fibromyalgia, * those who underwent physical therapy for at least the previous 3 months

Keywords: shock wave therapy magnesium sulfate iontophoresis low back pain
mini stem radiostereometric analysis study

Conditions: Osteoarthritis, Hip

Summary: the objectives of this study are to assess migration of the mis stem compared to the synergy hip system using radiostereometric analysis (rsa), and to assess the long-term safety and effectiveness of the study device. this study will document any device-related surgical or post-operative complications and adverse radiographic observations. subjects meeting the entrance criteria specified in this protocol will be randomized as they become available.

the purpose of the current investigation is to compare migration of the device after implantation with a modular, short hip stem called the "mis stem" or a standard tha using the synergy hip system using rsa. the intended use of this product is for patients with inflammatory and non-inflammatory degenerative joint disease who require a primary total hip replacement.

Eligibility criteria:
inclusion criteria: * subject has hip disease that requires a total hip arthroplasty. * subject is willing to consent to participation in the study. * subject plans to be available for follow-up through study duration. * subject is of stable health and is free of or treated and stabilized for any condition that would prose excessive operating risk. exclusion criteria: * subject has insufficient femoral bone stock. * subject has had major non-arthroscopic surgery to the study hip. * subject has physical, emotional or neurological conditions that would compromise the subjects compliance with postoperative rehabilitation and follow-up. * subject has a known sensitivity to materials in the device.
asthma patient survey study to assess asthma effect and medication in finland

Conditions: Asthma

Summary: this study was aimed at clarifying how the asthma medication is used in practice and how asthma affects everyday life. total of 106 gps were asked to recruit patients using inhaled steroid as maintenance treatment for asthma to take part in a telephone survey. altogether 142 patients were interviewed.


Eligibility criteria:
inclusion criteria: * diagnosed persistent asthma * regular use of inhaled steroids and concomitant medication exclusion criteria: * never been diagnosed copd * seasonal asthma

Keywords: asthma use of asthma medication asthma control telephone survey patient's perception
the relationship between hla tissue compatibility and biliary complications in patients with liver transplantation

Conditions: Liver Transplant; Complications; HLA Antigens

Summary: liver transplantation has become the accepted treatment option for advanced liver failure in recent years. in addition to the increase in the number of centers performing transplant and the decrease in complication rates depending on the experience gained, the most common biliary complications did not improve at the desired level. for this reason, studies in this field are frequent today. the structural complexities of hla antigens have been the subject of investigation in recent years. with the development of dna and rna amplification methods; it is increasingly difficult for physicians to keep up with the increasing burden of knowledge regarding the genetic aspects of these antigens. concrete benefits of this gene complex, which has been investigated in various fields and preserves its mystery, have not been determined in liver transplant patients. however, there are publications showing its connection with the bile epithelium in liver transplantation and its relationship with the disappearing bile duct syndrome. in this study, our aim is to explain whether the bile duct complications, which appear like a continuous wall and can lead to frightening pictures, are related to hla tissue compatibility.


Eligibility criteria:
inclusion criteria: * patients with liver transplantation and tested for hla antigen (recipient - donor) exclusion criteria: * patients who died early patients whose hla antigen is not checked

Keywords: liver transplant complications hla biliary fistula biliary stricture
multicenter study evaluating the safety of proellex® in premenopausal women with uterine fibroids

Conditions: Uterine Fibroids

Summary: the safety of proellex 25 and 50 mg administered once daily for three treatment cycles (four months each) will be evaluated.

subjects will be randomized to either proellex dose, 25 mg or 50 mg, in a 1:1 ratio. subjects will receive drug for a four (4) month cycle of therapy three (3) times, each treatment cycle being separated by an off-drug interval until menstruation occurs. during the treatment periods, all subjects will be assessed monthly. subjects will undergo an additional follow-up for 3 months following their last treatment visit.

Eligibility criteria:
inclusion criteria: * speak, read and understand english or spanish; * not have undergone hysterectomy, uterine arterial embolization or endometrial ablation therapy (previous myomectomy is acceptable) for any cause and no surgical interventions for uterine fibroids (e.g. hysterectomy, myomectomy, uterine arterial embolization) are planned or anticipated during the study; * one uterine fibroid must be identifiable and measurable by transvaginal ultrasound; * menstrual cycle lasting from 24 to 36 days; * history of excessive menstrual bleeding; * negative urine pregnancy test at screening. additional inclusion criteria may apply. exclusion criteria: * six months or more (immediately prior to screening visit) without a menstrual period; * prior hysterectomy; * prior bilateral oophorectomy; * pregnant or lactating females or women who are attempting or expecting to become pregnant at any time during the study; * documented endometriosis, active pelvic inflammatory disease (pid), platelet dysfunction, or von willebrand's disease; * any history or diagnosis of gynecological cancer or cervical dysplasia of any grade including atypical squamous cells of undetermined significance (ascus) associated with human papilloma virus (hpv); * subject with diagnosed or suspected carcinoma of the breast, reproductive organs or any other organ system; * subject with known active infection with hiv, hepatitis a, b or c, gonorrhea, or chlamydia or previous history of auto-immune disease or positive serum antinuclear antibodies. additional exclusion criteria may apply.

Keywords: uterine fibroids