Kornimate/medical-research-clean huggingface dataset:
letrozole add-on in the treatment of cesarean scar pregnancy

Conditions: Cesarean Scar Pregnancy

Summary: it is hypothesized that the inhibition of estradiol production by letrozole may interfere with physiological effects of progesterone necessary to maintain the pregnancy. there is no reference treatment of cesarean scar pregnancy (csp) as the limited number of cases precludes the extrapolation of results. in our center we successfully use two-step treatment with methotrexate (mtx) followed by hysteroscopic removal of products of conception (poc). the time in between is needed to achieve a decrease in the trophoblast's vital potential (b-hcg fall) and its vascularization. additional administration of letrozole could further reduce the vital potential of the pregnancy, eliminating the need for another dose of mtx, resulting in faster healing and lower rate of complications.

a prospective cohort study is conducted among women with cesarean scar pregnancy (csp). women with increasing b-human chorionic gonadotropin (b-hcg) concentrations are included. two study arms were planned: * women treated with a single dose of 100 mg mtx intravenously and 50 mg mtx in intra-amniotic injection (day 0), along with 30 mg potassium chloride in case of positive fetal heartbeat (fh) * women treated with a single dose of 100 mg mtx intravenously and 50 mg mtx in intra-amniotic injection (day 0), along with 30 mg potassium chloride in case of positive fetal heartbeat (fh) with additional use of letrozole 5 mg orally (from day 0) for 10 days. blood parameters (b-hcg, hemoglobin, total blood count, creatinine, urea, alanine/aspartate transaminase, gamma-glutamyltransferase, bilirubin) were tested on days 0,4,7, followed by b-hcg concentration measurement every 7 days until surgery. after obtaining satisfactory decrease in b-hcg and poc vascularization, women underwent hysteroscopic evacuation of poc. blood loss parameters, frequency of conversion from hysteroscopy to laparoscopy and laparotomy were measured. the women were given the option to choose the treatment used in the study. all enrolled women gave informed written consent to participate in the study.

Eligibility criteria:
inclusion criteria: * csp confirmed on pelvic ultrasound * consent of the bioethics committee for termination of csp * increasing b-hcg concentrations exclusion criteria: * heterotopic pregnancy * decreasing b-hcg concentrations

Keywords: cesarean scar pregnancy operative hysteroscopy
the effect of dietary nitrate supplementation on ability of individuals with type 2 diabetes to perform exercise

Conditions: Type 2 Diabetes

Summary: the investigators are conducting a research study to see if increasing the amount of nitrate (a substance found in large quantities in certain vegetables) in the diet can increase the ability of individuals with type 2 diabetes (t2d) to perform exercise. some people with t2d find exercise more uncomfortable than individuals who do not have t2d. this may be explained by the experimental studies showing that t2d can result in reductions in the supply of oxygen to the muscles. studies have also shown that for a given level of activity, individuals with t2d will be much closer to their maximum exercise capacity than healthy individuals. dietary nitrate may have two important beneficial effects in individuals with t2d: 1) the effects of dietary nitrate on the responses to exercise may have a significant impact on the ability of individuals with type 2 diabetes to perform daily tasks and exercise more comfortably and 2) experimental studies suggest that increased nitrate consumption has been shown to reduce the amount of oxygen required for a given level of exercise. the investigators will recruit 60 individuals with t2d. these people will take part in a randomised crossover design study where they will be asked to drink normal beetroot juice (rich in nitrate) and nitrate depleted beetroot juice, prior to performing two different walking exercise tasks (a six minute walk and repeated, low intensity treadmill walking). this study aims to determine if dietary nitrate supplementation reduces the amount of oxygen required for a given level of exercise in individuals with t2d. to test brain function individuals will be asked to perform a standard computerised decision making task following consumption of the nitrate rich and nitrate depleted juices.


Eligibility criteria:
inclusion criteria: * patients with t2d (as defined by who) of at least 5 years duration between the ages of 35-75 will be invited. exclusion criteria: * patients with significant renal impairment (egfr\<30) * uncontrolled hypertension * bmi\ 35 * are taking regular organic nitrates, nicorandil, or thiazolidinidiones, or any medication which may interfere with data interpretation or safety * who have had a myocardial infarction or cerebro-vascular event * who smoke, or any other serious medical condition which would interfere with data interpretation or safety will be excluded from participation.
combined fractional co2 laser with topical tioconazole versus q-switched nd:yag laser in the treatment of onychomycosis; a randomized controlled trial

Conditions: Onychomycosis of Fingernail

Summary: our aim is to assess the clinical efficacy and the safety of fractional co2 laser combined with topical tioconazole versus q-switched nd:yag laser in the treatment of om.


Eligibility criteria:
inclusion criteria: * • age group \>18 years. * patients of both genders. * patients with om any type. exclusion criteria: * • pregnancy * localized bacterial infection around the affected nail * concomitant nails disease that causes nail dystrophy or discoloration such as psoriasis, lichen planus and atopic dermatitis that may interfere with diagnosis and treatment * hypersensitivity to terbinafine * intake of oral antifungal medication within the last 3 months or used topical antifungal medication within the last 2 weeks prior to the laser treatment
immediate stiffness changes in myofascial trigger points after dry needling

Conditions: Myofascial Pain Syndrome; Neck Pain; Trigger Point Pain, Myofascial

Summary: shear-wave elastography (swe) is considered as a useful tool for quantifying muscle stiffness. considering that myofascial trigger points (mtrp) are defined as "hyperirritable zones in contracted bands of muscle, thought to be caused by muscle overload or stress" and the effectiveness of dry needling applied to active mtrp for reducing pain and disability, the aim of this study is to assess the effects of sham and real dry needling, applied to active mtrp in the upper trapezius muscle in patients with chronic neck pain, on the muscle stiffness in two areas: 1) the most symptomatic area and 2) a control point.


Eligibility criteria:
inclusion criteria: * patients between 18 and 65 and * presence of mechanical neck pain for at least three months duration * presence of at least one active mtrp in the upper trapezius muscle exclusion criteria: * neck pain of traumatic origin (such as whiplash-associated disorder) * current use of any kind of analgesic therapy * presenting any condition usually considered a perpetuating factor of mtrps, such as fibromyalgia, hypothyroidism, or iron deficiencies * presenting any contraindication for dry needling application * neuropathies (e.g., radiculopathy) * bilateral pain
will perceptual learning via video game playing improve visual acuity stereopsis & fixation stability in mild amblyopes?

Conditions: Amblyopia

Summary: contrast balanced dichoptic videogame training has been found to improve sensory functions in adults with amblyopia; best corrected distance visual acuity (bcva) and stereopsis, but its effect on motor function, namely amblyopic eye fixation stability, is unknown. furthermore, the effect of treatment in cases of mild amblyopia is not well understood. the aim of this study is to find out the difference on fixation stability, bcva and stereopsis in mild amblyopes after 6 weeks' contrast balanced dichoptic video game training.

objectives: to assess the change of fixation stability as well as visual acuity and stereopsis before and after training mild amblyopia by perceptual learning through dichoptic video game playing. hypothesis: it has been shown that the visual acuity, stereopsis and fixation stability are compromised in amblyopic eye. perceptual learning via video game playing has been found effective in improving visual acuity and stereoacuity in moderate and severe amblyopic eyes, but there is no study on such treatment in mild amblyopia. in this study, we hypothesize that fixation stability, visual acuity and stereopsis will be improved after training by dichoptic video game playing in mild amblyopia. methods: participants (aged 7 or above) with best corrected visual acuity (bcva) ≤ 0.28 logmar in the amblyopic eye and an interocular acuity difference ≥ 0.2 logmar will be recruited. an anaglyphic, contrast balanced dichoptic video game will be provided on an i-pod touch (apple inc.) for 6 weeks of home-based training (60 mins per day). fixation stability quantified using bivariate contour ellipse area (bcea by micro-perimeter (mp) nidek mp-1), bcva and stereopsis will be assessed before and after treatment.

Eligibility criteria:
inclusion criteria: * best corrected va in amblyopic eye ≤ 0.28 log mar, fellow eye va with an interocular va difference ≥ 0.20 log mar; * amblyopia could be in form of strabismic, anisometropic and mixed (both strabismic and anisometropic) * able to complete 3 successful measurements (each with 30 seconds fixation) of bcea by the mp-1 systems in each eye * able to align the nonius cross (≤10mm horizontal error and 5mm vertical error) in the i-pod game exclusion criteria: * myopia of spherical equivalent power \> -6.0 diopter in either eye * previous intraocular surgery * any types of ocular pathology (e.g. media opacities or retinal lesion) * previous or current history of neurological problem

Keywords: amblyopia fixation stability perceptual learning
developmental hip dysplasia and physical therapy

Conditions: Hip Dysplasia, Congenital

Summary: developmental hip displasia (ddh) can cause various degenerations or compensatory adaptations in the spine and knee joint, especially in the hip joint. as a result of adaptations and degeneration, these individuals may experience difficulty in walking and functional activities, lack of stabilization, decreased muscle strength and activation, and loss of balance at varying levels. this situation necessitates a holistic, multifaceted rehabilitation in individuals with hip dysplasia. there is no study in the literature that shows a specific physiotherapy and rehabilitation program applied to individuals with ddh. the aim of this study was to investigate the efficacy of classical physiotherapy method in patients with ddh and to compare the efficacy of classical physiotherapy and core stabilization exercise training in treatment.

the study will be conducted in two groups. individuals with ddh will be divided into two groups as conventional physiotherapy group and core stabilization group. it will be ensured that the distribution of the individuals in the groups in a randomized manner, with the disease stages of the two treatment groups being the same and the clinical characteristics are similar. the population of the study, individuals diagnosed with ddh by the orthopaedic surgeon, routinely directed to physiotherapy and rehabilitation, examined by the responsible investigator and who were referred to our clinic for the research, will be evaluated twice(before and after treatment) and will be treated for 3 times a week for 6 weeks. the study will consist of female individuals aged 20-60 who voluntarily agree to participate in the study (2 times evaluation and 18 times treatment). it is planned to involve at least 16 individuals. individuals who meet the criteria for inclusion in the study and volunteers will be included in the study by signing the informed voluntary consent form. in hacettepe university, department of physiotherapy and rehabilitation, pain severity of subjects with ddh will be evaluated with digital analogue scale (sas) and algometer, joint range of motion with goniometer, muscle strength with digital dynamometer, walking with gaitrite device, balance with bertec device and hip functions, kineyophobia, questionnaires will be given to evaluate quality of life and mood. after the first evaluation, individuals will be treated 3 times a week for 6 weeks and then the first evaluations will be done again. the data obtained before and after treatment will be compared between the two treatment groups.

Eligibility criteria:
inclusion criteria: * age between 20-60 years old * non-operated (total hip arthroplasty) exclusion criteria: * neurological disease * cognitive problems

Keywords: developmental hip dysplasia physiotherapy gait core stabilization balance
bioflow-viii all-comers orsiro mission safety and performance registry

Conditions: Coronary Artery Disease; Myocardial Ischemia

Summary: the bioflow-viii registry is a post-market clinical evaluation of the orsiro mission stent in subjects requiring coronary revascularization with drug eluting stents (des).

bioflow-viii is a national, prospective, non-randomized, multi-center, open-label registry to confirm both, the acute performance as well as the mid- and long-term safety and clinical performance of the orsiro mission stent in an all-comers patient population within daily clinical practice. a total of 868 subjects will be enrolled at approximately 50 study sites in france. clinical follow-ups will take place at 6, 12, 36 and 60 months post index-procedure. follow-ups can be conducted by telephone. a subgroup analysis will evaluate the outcomes for patients treated ambulatory with same day discharge.

Eligibility criteria:
inclusion criteria: * symptomatic coronary artery disease intended to be treated with an orsiro mission des (silent ischemia is permitted) * subject has signed informed consent for data release * subject is geographically stable and willing to participate at all follow up assessments * subject is ≥ 18 years of age exclusion criteria: * subject did not sign informed consent for data release * pregnancy * known allergy (which cannot be pre-treated) to all types of p2y12 inhibitor (clopidogrel, ticagrelor, prasugrel, ticlopidine and cangrelor; thus preventing the use of the appropriate p2y12 inhibitor), aspirin, both heparin and bivalirudin, l-605 cobalt- chromium (co-cr) alloy or one of its major elements (cobalt, chromium, tungsten, nickel), silicon carbide, plla, mtor inhibiting drugs such as sirolimus, or contrast media

Keywords: observational registry all-comers open-label registry percutaneous coronary intervention (pci) coronary revascularization orsiro mission drug eluting stent (des) stenting
the effect of listening to music and stress ball application on patients' anxiety level and hemodynamic parameters during pci

Conditions: Percutaneous Coronary Intervention; Anxiety; Hemodynamics

Summary: in this study, it was aimed to determine the effects of listening to music and applying a stress ball on patients' anxiety level and hemodynamic parameters during percutaneous coronary intervention (pci).

percutaneous coronary intervention causes patients to experience anxiety and change their hemodynamic parameters. in this study, it was aimed to determine the effects of listening to music and applying a stress ball on patients' anxiety level and hemodynamic parameters during percutaneous coronary intervention.

Eligibility criteria:
inclusion criteria: * 18 years and older, * literate, * able to communicate verbally, * turkish speaking, * no hearing or vision loss, * no sensory or motor deficits in the hand or arm, * percutaneous coronary intervention will be applied, * intervention from the femoral artery, * voluntarily participated in the research, * patients signing the informed consent form will be included. exclusion criteria: * under the age of 18, * not signing the informed consent form, * illiterate, * unable to speak turkish, * unable to communicate verbally * those who have a neurological or psychiatric disease that prevents communication, * hearing and sight impaired, * those who have had a mastectomy * those with arterio-venous fistula * percutaneous coronary intervention has been performed in the last 2 years, * restricted special groups (pregnant women, criminal convicts, etc.), * emergency cases where communication cannot be established, * those with equipment problems such as monitors and cuffs, * those who will be given sedatives during the procedure, * those who will be taking cardiovascular system medications other than routine practices during the procedure, * those who will be given oxygen during the procedure, * patients who are treated from a different artery other than the femoral artery will not be accepted. criteria for exclusion from follow-up: * those who want to quit working, * those who give up listening to music, * those who give up using the stress ball, * those who were given cardiovascular system medications other than routine practices during the procedure, * those who underwent intervention from a different artery instead of the femoral artery, * those who do not want to wear headphones because they cannot hear the doctor's questions * those whose second measurements could not be taken because they were quickly removed from the interventional room, * those who underwent carotid artery angiography in addition to coronary artery, * those who give incorrect pci history, * those who cannot listen to music or whose music is interrupted due to connection problems, * those whose intervention cannot be performed at the planned time due to urgent patient arrival,

Keywords: percutaneous coronary intervention anxiety hemodynamics music stress ball
medical abortion up to 10 weeks gestation at home

Conditions: Pregnancy Complications; Legally Induced Abortion Without Mention of Complication

Summary: medical abortion performed in the womens home has shown to be safe and acceptable up to 9 weeks of gestation. our project is aiming to confirm our hypothesis that it is equally effective, safe and acceptable when the gestation is more advanced, up to 10 weeks of gestation.

the study will include 600 women opting for medical abortion. women wanting to perform the last part of the abortion in their homes will be invited to participate. 300 women with a pregnancy up to 9 weeks of gestation (63 days) will be compared to 300 women with a gestation length between 64 and 70 days of gestation. the primary endpoints will be number of patients with an incomplete abortion, with a need for surgical or pharmaceutical intervention. secondary endpoints include duration of bleeding, acceptance and satisfaction with the method and number of additional visits to the clinic/facility. the study will be performed in five abortion clinics in sweden.

Eligibility criteria:
inclusion criteria: * healthy * requesting and eligible for medical abortion * confirmed intrauterine pregnancy * gestational length no more than 70 days * hemoglobin over 100g/l exclusion criteria: * anemia * contraindication to mifepristone (steroid-dependant cancer, porphyria) * breast feeding * advanced pregnancy (\>70 days) * known liver disease * bleeding disorder * arterial hypertension

Keywords: medical abortion home abortion
gripwise® versus jamar®

Conditions: Age-Related Sarcopenia

Summary: it is recommended to screen ageing patients for sarcopenia, due to the increased risk of morbimortality if detected positive. according to the consensus of the european working group on sarcopenia in older people, the diagnosis of sarcopenia is based, among other things, on grip strength measurement. our study will compare the performance of the new gripwise digital device with the mechanical dynamometer jamar, the gold standard currently used to assess the grip strength. we propose to evaluate it in an elderly hospitalized population where the prevalence of sarcopenia is likely to be high due to the high prevalence of various chronic illness, notably oncological and cardiological ones. this cross-sectional study will include 348 patients.


Eligibility criteria:
inclusion criteria: * men and women aged 65 or over * affiliated to a health insurance * francophone. exclusion criteria: * - refusal to participate * unable to communicate * unable to use both hands (dominant and non-dominant)

Keywords: aged inpatients hand strength
a novel selective block of the suprascapular nerve

Conditions: Ligament Injury; Fracture

Summary: patients who receive the lateral and sagittal infraclavicular block (lsib) tend to supinate their hand and forearm which may hamper optimal positioning for surgery of the dorsal side of the hand. the investigators think that this supination is caused by lateral rotation in the shoulder. the main lateral rotator of the shoulder is the infraspinatus muscle, which is innervated by the suprascapular nerve (ssn).the investigators hypothesized that optimal positioning of the hand for surgery on the dorsal side of the hand may be achieved by performing a ssn block (ssnb) in addition to the lsib.

according to the hypothesis the investigators will perform a double blind , placebo controlled study to answer the research question above.

Eligibility criteria:
inclusion criteria: * patients with american society of anesthesiologists physical status (asa) i- iii * age between 18 and 70 years * body mass index between 20 and 36 kg/m2 scheduled for elective hand surgery. exclusion criteria: we will measure the angle between wrist and horizontal plane while the patient is supine and the extended arm 75° abducted. * patient who are not able to pronate the hand ≤15° before block performance, will be excluded from the study. * patients will also be excluded if they are pregnant, have contraindications to regional anesthesia, coagulation disorder, allergy to local anesthetics (la), atrioventricular block, peripheral neuropathy or drug-treated diabetes. * patients using other anticoagulation drugs than acetylsalicylic acids or dipyridamol will be excluded.

Keywords: brachial plexus block suprascapular nerve block
diagnostic value of whole-body mri for rectal cancer preoperative staging

Conditions: Rectal Cancer

Summary: the purpose of this study is to determine whether whole-body mri (wb-mri) accuracy is superior to fdg-pet-ct considered as the gold-standard for the staging of distant lesions of rectal cancer.

rectal cancer is the second cause of mortality after lung cancer in industrialized countries and represent 28% of colorectal carcinomas. despite major improvements in diagnosis and treatment made those last years,mortality and morbidity remains high, because of high prevalence of metastasis and local recurrence. a accurate initial staging is of paramount importance for an appropriate treatment (neoadjuvant chemiotherapy and radiotherapy, surgery). actually, there is no international consensus concerning imaging for the staging of rectal cancer and modalities used are variable from one center to another. wb-mri represented a attractive and promising technique for the staging of rectal cancer, free of ionizing radiation .

Eligibility criteria:
inclusion criteria: * rectal cancer t3 n+ or t3 or t4 exclusion criteria: * renal failure * allergy to iodinated contrast medium * contraindication to mri

Keywords: rectal cancer whole-body mri fdg-pet-ct preoperative staging