Kornimate/medical-research-clean huggingface dataset:
effect of mango on gut microbiota and metabolic health

Conditions: Gut Microbiota; Metabolic Syndrome

Summary: mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. polyphenols accumulate in the gut where they can positively modulate the microbiota. as gut microbiota may have a strong influence on cardiometabolic health, we hypothesize that mango consumption improves metabolic profile in overweight or obese individuals through beneficial changes in gut microbiota. the study of metagenomics, transcriptomics and metabolomics will be used to validate this hypothesis.


Eligibility criteria:
inclusion criteria: * healthy men and premenopausal women * at least one of the following : bmi between 25 and 40 kg/m2 or waist circumference ≥ 80 cm for women and ≥ 94 cm for men * at least one of the following : tg ≥ 1.35 mmol/l or fasting insulinemia ≥ 42 pmol/l * caucasian origin exclusion criteria: * nicotine use * metabolic disorders or use of medication that may affect parameters measured in the study * use of dietary supplements or natural health product that may affect parameters measured in the study * use of antibiotics in the last 3 months * surgery in the last 3 months or planned during the study timeline * alcohol consumption \>2 drinks/day * weight change \>5% in the last 3 months * mango aversion, allergy or intolerance * dietary restrictions (vegetarian, gluten avoidance...) * berries consumption \>1 serving/day * pregnancy, breastfeeding or pregnancy planned within 3-6 months

Keywords: mango polyphenols inflammation insulin resistance transcriptomic metabolomic metagenomic
recovery of physical functioning after hip fracture

Conditions: Femoral Neck Fractures

Summary: the survivors after hip fracture often report severe pain and loss of physical functioning. the poor outcomes cause negative impact on the person's physical functioning and quality of life and put a financial burden on society. it is important to continue and progress the functional training that already started at the hospital, while the patients are transferred to short-term stays in a nursing home before they are returning to home. the aim presently is to examine the effects of a functional training program by a rct design, initiated by the physiotherapist and performed by the nurses, on physical functioning while the patients are at short term stays in primary health care.

functional training, such as walking and transfers, ought to be an important part of the rehabilitation after hip fracture. we have an assumption that it is of utmost importance to continue and progress the functional training that started in the acute phase at the hospital, also during the sub-acute phase while the patients are at short-term stays in nursing homes. however, there are indications of lack of resources in the nursing homes and that the nurses may be less concerned with their role and participation in the patients' rehabilitation process. possibly, this creates a discontinuity in the rehabilitation efforts during short-term stays that may have a negative impact on the patients' recovery of physical functioning. in this study the aim is to continue and progress the functional training started during hospital stay, such as training in walking and further on repetitive sit-to-stands, as part of the daily habitual routine during short-term stays in the nursing homes. this type of functional training may be motivational and easily recognizable to the patients, and it can also be carried out by the nursing staff with only initial guiding from a physiotherapist. there is lack of knowledge on the effect of additional functional training, incorporated as part of the habitual daily routine during short-term stays, on the patients' immediate and long term recovery of physical functioning and activity level after hip fracture, compared to usual care alone. the study is designed as a single-blind randomized controlled trial (rct), comparing the effects of additional functional training (functional training group)to usual care alone (control group) during short-term stays in nursing homes.

Eligibility criteria:
inclusion criteria: * patients with an acute low-energy hip fracture (intracapsular, trochanteric or subtrochanteric) and treated surgically, ≥ 65 years of age, living in their own homes prior to the fracture, and able to give an informed consent. exclusion criteria: * patients unable to walk 10 meters with or without a walking aid prior to the fracture, have a score of less than 15 points on minimal mental status evaluation (mms-e) in the acute phase, have a pathological fracture, life expectancies of less than three months, medical contraindications for training, or are incapable of understanding and speaking the norwegian language.
inherited susceptible genes among epithelial ovarian cancer

Conditions: Ovarian Neoplasm Epithelial; Hereditary Breast and Ovarian Cancer Syndrome

Summary: purpose: to investigate the prevalence of the germline mutations in the brca 1/2 and mismatch repair genes in patients with epithelial ovarian cancer (eoc) and their relatives, and related somatic mutations in tumor tissues in the northern part of china. patients and methods: a multicenter prospective study will be hold in the northern part of china form 2017. about 1000 female patients with epithelial ovarian cancer and their ralatives will be tested for germline mutations in the brca 1/2 and mismatch repair genes and related somatic mutations in tumor tissues, regardless of the family history. study type: observational official title: prevalence study of germline mutations in susceptibility ovarian cancer genes in patients with epithelial ovarian cancer and somatic mutations in their tumor tissures in the northern part of china. enrollment: 1000


Eligibility criteria:
inclusion criteria: 1. epithelial ovarian cancer and their relatves 2. living in the north of huaihe river in china 3. being han chinese exclusion criteria: 1. non-epithelial ovarian cancer 2. without specific pathological diagnosis 3. non-han chinese

Keywords: epithelial ovarian cancer hereditary breast and ovarian cancer syndrome next-generation sequencing high-throughput nucleotide sequencing
maternal characteristics associated with child growth and adiposity

Conditions: Obesity; Obesity, Infant

Summary: the goal of this observational study is to investigate the concentrations of leptin, insulin, liver expressed antimicrobial peptide 2 (leap2), and cortisol in plasma and breast milk and their relationship with eating behavior, growth, adiposity and with the levels of these hormones in infants, comparing mothers with normal weight and with pre-pregnancy overweight/obesity. the main question\[s\] it aims to answer are: * are maternal hormones associated with child growth and adiposity * are maternal hormone receptors associated with child growth and adiposity * are infant hormones and their receptors associated with child growth and adiposity participants will provide milk and blood samples. researchers will compare mothers with normal weight and with pre-pregnancy overweight/obesity to see if there are differences in child growth and adiposity .


Eligibility criteria:
inclusion criteria: * lactating women with pre-pregnancy normal weight and overweight or obesity as described by the world health organization. exclusion criteria: * diabetes (type i or ii or gestational) * multiple pregnancy * hypertensive disorders during pregnancy * delivery of pre-term infant (\<37 weeks).
pre-approval access to pimodivir for the treatment of patients with h7n9 influenza a infection

Conditions: H7N9 Subtype of Influenza A Virus

Summary: the purpose of this program is to provide pre-approval access to pimodivir for the treatment of a patient(s) with h7n9 influenza a infection. pre-approval access pertains to provision for therapeutic use of an investigational product prior to its marketing authorization. such access may be considered for eligible patients with serious/life-threatening diseases or conditions, where alternative treatments do not exist or have been exhausted.


Eligibility criteria:
inclusion criteria: * the patient has an h7n9 influenza a infection * the patient has no known severe hepatic impairment exclusion criteria: - any other influenza a sub-strains other than h7n9
influence of emotional disorders and executive on the components retrograde and anterograde episodic memory in ms

Conditions: Multiple Sclerosis

Summary: multiple sclerosis (ms) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease. various studies have shown that there was a breach of episodic memory, working memory, attention and executive functions regardless of the form of disease, disability or duration of disease progression. the main objective of this study is to investigate the influence of emotional components and executive processes on the components retrograde and anterograde episodic memory (thanks to an original paradigm based on the emotional valence of the memory) in ms patients


Eligibility criteria:
inclusion criteria: * men and women 30-60 years of age * definite ms (mcdonald criteria revised in 2005) * edss \<6 * sick shapes: relapsing multiple sclerosis, primary progressive multiple sclerosis * all durations evolution * french mother tongue * signature of informed consent exclusion criteria: * other neurological conditions, previous psychiatric or developmental diagnosis of ms * head injury sequelae * chronic alcohol or drugs taking * edss greater than or equal to 6 * secondary progressive form * push and / or treatment with corticosteroids within one month * treatments amantadine, modafinil introduced for less than 3 months * patient trust * cognitive assessment of less than one year (including in particular all or part of the balance sheet proposed in this project) * any visual motor deficit or incompatible with the award of cognitive tests * for women, pregnancy, breastfeeding and / or lack of contraception (a pregnancy test will be done before the pet scan) * patient with indications against mri
safety and efficacy study of pitavastatin in patient with a metabolic syndrome

Conditions: Hypercholesterolemia; Metabolic Syndrome

Summary: we will identify the influence of long-term treatment of pitavastatin compared to non-treatment control group on the metabolic syndrome by evaluation of a change of metabolic syndrome component score. and we will additionally observe the changes of cvd risk factors like lipid profile, abdominal fat, insulin resistance and so on.


Eligibility criteria:
inclusion criteria: * patients aged between 18 and 75 * patients with ldl ≥ 100mg/dl * patients with metabolic syndrome 1. ifg: fasting glucose ≥ 100mg/dl 2. abdominal obesity: waist circumference: men≥90cm,women≥85cm 3. 1 or more of the following 1. triglyceride ≥ 150mg/dl 2. hdl-c: men \< 40mg/dl, women \< 50mg/dl 3. blood pressure: sbp ≥ 130mmhg or dbp ≥ 85mmhg or subject receiving anti-hypertensive treatment exclusion criteria: * uncontrolled hypertension (dbp ≥ 95mmhg) * taking diabetic drugs or with hba1c \> 8% * ldl ≥ 190mg/dl or triglyceride ≥ 400mg/dl * coronary heart disease or other diseases caused by artherosclerosis * malignancy within 6 months * serum creatinine ≥ 2.0mg/dl * alt or ast ≥ uln\*2.5 * cpk ≥ uln\*2 * hypothyroidism

Keywords: pitavastatin metabolic syndrome metabolic syndrome risk score hypercholesterolemia
a study of eribulin with gemcitabine in patients with advanced liposarcoma or leiomyosarcoma

Conditions: Sarcoma

Summary: the eribulin, a microtubule-dynamics inhibitor was approved for specific subtypes of sts. eribulin demonstrated significantly better os compared to dacarbazine in previously treated patients with liposarcoma and leiomyosarcoma and approved as standard treatment. however, the median progression free survival (pfs) and response rate (rr) was similar for both groups which remains modest outcome of 2.6 months of pfs and 4% of rr. therefore, to improve antitumor activity, further combination strategy is strongly warranted. based on the previous studies, investigators suggest phase ii trial of eribulin and gemcitabine combination in previously treated patients with unresectable, advanced, or metastatic leiomyosarcoma or liposarcoma.


Eligibility criteria:
inclusion criteria: 1. histologically confirmed advanced liposarcoma or leiomyosarcoma with 1-2 prior chemotherapy including anthracycline (unless contraindicated) 2. ecog performance status of 0-2 3. measurable or evaluable disease (recist 1.1.) 4. adequate laboratory findings * hb ≥ 9.0 g/dl * absolute neutrophil count ≥ 1000 /µl * platelet ≥ 75,000/ µl * total bilirubin: ≤ 1.5 × unl (upper normal limit) (≤ 2 × unl in patients with liver metastasis) * serum creatinine: ≤1.5 x upper limit of normal (uln) or ≥ creatinine clearance 60 ml/min (cockcroft-gault) for patients with creatinine levels \> 1.5 x institutional uln * ast(sgot)/alt(sgpt): ≤ 3.0 × unl or ≤ 5.0 × unl (in patients with liver metastasis) * alkaline phosphatase : ≤ 3.0 × unl or ≤ 5.0 × unl (in patients with liver or bone metastasis) * prothrombin time and partial thromboplastin time : ≤1.5 x uln 5. female patient of childbearing potential has a negative serum or urine pregnancy test within 72 hours prior exclusion criteria: 1. more than 3 prior cytotoxic agents 2. patient who has had chemotherapy, radiotherapy, or biological therapy within 2 weeks prior to entering the study 3. uncontrolled or active cns metastasis and/or carcinomatous meningitis 4. patient has known hypersensitivity to the components of study drugs or its analogs. 5. patient is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study. 6. long qt syndrome ≥480 ms 7. peripheral neuropathy ≥2 with previous treatment 8. unstable cardiovascular disease 9. symptomatic interstitial lung disease (ild) or presence of ild on chest x-ray
qualitative pain measurement at patients with degenerative low back pain

Conditions: Degeneration of Lumbar Intervertebral Disc

Summary: the purpose of the study is: * to measure sensitization of the nociceptive system at patients with low back pain in order to carry out a necessary surgical procedure * to examine a possible association between low back pain and degenerative changes * to analyse if low back pain is related to the clinical result 6 months after surgery * to set up a model for pre-operative measurement of pain.


Eligibility criteria:
inclusion criteria: * patients who are going to be treated surgically for spondylitis * ability to understand danish in order to filling in a questionnaire * a written signed statement of consent exclusion criteria: * removal of implants * diabetic neuropathy or another neuropathic disease * neurological diseases * unability to read or understand danish

Keywords: pain sensitization spondylitis
effectiveness of a mobile application as an adjunct to medical advice to promote healthy habits

Conditions: Overweight; Obesity

Summary: introduction: obesity is the most common metabolic problem and its genesis and maintenance there is always a positive energy balance, with less energy expenditure than that obtained from the intake. low physical activity is often an important factor in this lower spending. medical advice is useful for determining changes in the habits of life of patients, however, the changes produced by the council do not last over time, so it would be necessary to establish enforcement mechanisms as with mobile technology, because it could improve the adhesion of obese patients to therapy. objective: primary: to evaluate the effectiveness of an app as an adjunct to medical advice to promote healthy living habits (sport and diet) to lose weight in a population of obese or overweight adult patients. material and methods: open randomized controlled clinical trial with clinical practice (health advice for physical activity and sport). study population: obese or overweight adults patients of araba aged between 18-45 years who be in contemplation stage with smartphone. variables: primary endpoint: weight (kg); secondary variables: bmi (kg/cm2); blood pressure (mm hg); heart rate; plasma cholesterol (mg / dl); hba1c; score on the satisfaction questionnaire; index of physical exercise (ipaq) (mets); quitting tobacco (yes / no); waist circumference (cm). statistical analysis: the primary endpoint (weight reduction) will be evaluated by covariance analysis adjusting by baseline weight, and other confounding variables (sex, age, level of education..) simple size: 48 patients by arm plus 20% to cover losses to follow.


Eligibility criteria:
inclusion criteria: * bmi\> = 25 mg / kg * holder smartphone * sign informed consent exclusion criteria: * presence of physical or mental illnesses that prevent the realization of physical activity * be participating in another research project * pregnancy or lactation * patients who are on diet or drug treatment for weight loss * history of myocardial infarction or stroke
comparative effects of cryotherapy and infrared light on pain, redness, and healing of episiotomy wound

Conditions: Episiotomy Wound

Summary: the study will be a randomized clinical trial and will be conducted in bahawalpur victoria hospital, bahawalpur. the subjects (n=24) will be divided into two groups. group a will include 12 postnatal women and for treatment, cryotherapy will be applied for 20 minutes. group b will include 12 women and receive infrared light, an infrared lamp will be put at a distance of 45 cm from the perineum, and the heat produced with 230 volts for twenty minutes. the participant will be checked after the first five minutes to make sure that she is not being burned. this procedure will be done twice a day for 7 consecutive days.

one of the most often used delivery methods is the episiotomy. severe side effects like infection, dehiscence of the incision, and perineal discomfort are possible. in addition to increased blood loss during birth, mothers who undergo episiotomy have the risk of experiencing delayed wound healing along with increased pain in the early puerperium. after birth, episiotomy treatment begins right away and would involve both pain management and local wound care. the data will be assessed on the baseline 3rd day and 7th day of treatment. a numeric pain rating scale (nprs) will be used to assess the severity of pain. reeda scale will be used for redness, edema, ecchymosis, discharge, and approximation (closeness of skin edges). spss version 25 will be used for analysis.

Eligibility criteria:
inclusion criteria: * women who underwent episiotomy between 6 to 24 hours postpartum. * delivered a live baby. * complete full-term labor. * episiotomy type medial and medio-lateral. * primiparous women and multiparous women. exclusion criteria: used pain-relieving drugs. * women with diabetes and pre-eclampsia. * febrile conditions. * severe infection. * chronic medical conditions that may affect wound healing. * allergies and sensitivity to heat/cold. * recent surgery of pelvis or abdomen.

Keywords: cryothrapy episiotomy infrared rays
database of positon emission tomography (pet) digital brain exams, in 50th age of patients

Conditions: Neurodegenerative Diseases

Summary: this study evaluate the interest to create a new database of pet digital brain exams in population of 50 years and over of patients. half of patients with no abnormal brain metabolism while the other half patients with alzheimer's disease.

the 18f-fdg cerebral pet can be performed for the detection of neurodegenerative diseases found hypometabolism in the areas concerned (alzheimer's disease, fronto-temporal dementia, dementia lewy body etc). the diagnosis is given by the clinician with a visual analysis of the data. technical aids are now recommended (european recommendations) to complete the diagnosis with a quantitative analysis of different brain regions to a healthy brain base, to guide the diagnosis, in addition to visual analysis. the emergence of a new technology has allowed the transition from analog pet / ct to digital pet / ct improving spatial resolution and image contrast. unlike analog pet / ct that uses photomultipliers to detect light, digital pet / ct uses the digital photon counting technique to directly convert light into a digital signal and each crystal is connected to a single detector. different software, used in clinical routine, gives access to a quantified analysis of different areas of the brain. however, these programs have been made with healthy subjects of reduced strength (for example, the neuro q ® software database is based on 29 healthy patients), with no specific age and thanks to analog pet / ct ( old generation). there is therefore a low specificity in terms of detection of degenerative pathologies, this being explained by a decrease in cerebral metabolism with age 9, mainly at the level of the anterior areas 10 (frontal lobe, temporopolar areas, insular areas, cortex anterior cingulate).

Eligibility criteria:
inclusion criteria: * having performed a 18f-fdg cerebral pet/ct exam as part of an alzheimer's assessment at the nuclear medicine department of nancy, sent by the geriatric department * patient who has received complete information on the organization of the research and who has not objected to the exploitation of this data * patient affiliated to a social security exclusion criteria: * patient who has received complete information on the organization of the research and who has objected to the exploitation of this data * for patients with no abnormality in 18f-fdg pet, mini mental state examination (mmse) \<25 or clinically diagnosed neurodegenerative pathology * for patients with typical hypometabolism of 18f-fdg pet/ct, biology of cerebrospinal fluid not in favor of alzheimer's disease

Keywords: neurodegenerative disease digital brain pet exam database
a study to assess the effects of switching from a biologic treatment to tildrakizumab using patient-reported outcomes in adult participants with moderate to severe plaque psoriasis

Conditions: Plaque Psoriasis

Summary: the main aim of this study is to assess the effects of switching from another biologic to tildrakizumab on patient-reported outcomes and to assess psoriasis intensity, patient's quality of life prior and after switching and the individual rationales for switching biologics.


Eligibility criteria:
inclusion criteria: 1. written informed consent. 2. \>=18 years of age. 3. moderate-to-severe plaque psoriasis currently treated with a biologic therapy (tnfα antagonist, il12/23 antagonist, il17 antagonist). 4. switch to tildrakizumab due to: 1. primary or secondary treatment failure (pasi \>= 3 or δpasi \ 5) 2. adverse events, contraindication, intolerance 3. patient wish (dosing regimen), lack of adherence, or other, including nonmedical reason 5. treatment with tildrakizumab planned in the frame of clinical practice. exclusion criteria: 1. patient appears to be unwilling or unable to comply with the requirements of the study or who, in the opinion of the investigator, should not participate in the study. 2. \>=3 previous biologic treatments in the last 3 years. 3. participation in a clinical trial simultaneous to participation in sw-atch. 4. any condition preventing prescription of tildrakizumab according to the smpc, including but not restricted to any contraindication or history of hypersensitivity or intolerance. 5. patient dependent on the investigator. 6. previous treatment with tildrakizumab.

Keywords: psoriasis tildrakizumab moderate-to-severe plaque psoriasis prospective