Kornimate/medical-research-clean huggingface dataset:
comparison between p2y12 antagonist monotherapy and dual antiplatelet therapy after des

Conditions: Coronary Artery Disease

Summary: to compare the efficacy and safety of clopidogrel monotherapy versus aspirin plus p2y12 antagonist following 3-month of dapt in patients undergoing pci with des.

this trial is a prospective, randomized, multi-center, open label, noninferiority trial. patients undergoing pci with des will be eligible. after successful pci with des, all eligible patients will be randomized either to clopidogrel monotherapy or to aspirin plus p2y12 antagonist following 3-month of dapt.

Eligibility criteria:
inclusion criteria: * subject must be at least 20 years of age. * subject is able to verbally confirm understandings of risks, benefits and treatment alternatives and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure. * patients undergoing successful pci exclusion criteria: * hemodynamic instability or cardiogenic shock * active bleeding * known hypersensitivity or contraindication to study medications * female of childbearing potential, unless a recent pregnancy test is negative, who possibly plan to become pregnant any time after enrollment into this study * non-cardiac co-morbid conditions are present with life expectancy \<2 year or that may result in protocol non-compliance (per site investigator's medical judgment). * des implantation within 12 months before index procedure

Keywords: drug-eluting stents aspirin p2y12 antagonist monotherapy
adnexal mass after methotrexate treatment for ectopic pregnancies

Conditions: Ectopic Pregnancies

Summary: ectopic pregnancies are a common morbidity in the gynaecological field. previous work done by our team has shown the benefits of conservative treatment with only bhcg (beta-human chorionic gonadotropin) monitoring, proving that a vast number of patients will have a self resolution without the need for any further medical intervention. in addition, our working hypothesis is that this process in contrast to methotrexate is a more physiologic one with less inflammatory and necrosis reaction. objective to measure and compare the size of the ectopic mass and monitor bhcg levels of women treated with methotrexate and those that had a self resolution process of their ectopic pregnancy. investigators aim to prove that the mass will have an enlargement trend after methotrexate in contrast to being stable or decrease in size with conservative treatment.

ectopic pregnancies are a common morbidity in the gynaecological field. previous work done by our team has shown the benefits of conservative treatment with only bhcg (beta-human chorionic gonadotropin) monitoring, proving that a vast number of patients will have a self resolution without the need for any further medical intervention. in addition, our working hypothesis is that this process in contrast to methotrexate is a more physiologic one with less inflammatory and necrosis reaction. objective to measure and compare the size of the ectopic mass and monitor bhcg levels of women treated with methotrexate and those that had a self resolution process of their ectopic pregnancy. investigators aim to prove that the mass will have an enlargement trend after methotrexate in contrast to being stable or decrease in size with conservative treatment. patients \& methods patients that will be offered to join the study are those that will be with either treated by a methotrexate injection or those that had signs of self resolution with our "watchful waiting" protocol.

Eligibility criteria:
inclusion criteria: all patients admitted and treated for a diagnosis of ectopic pregnancy in the department of gynecology, lis maternity hospital. exclusion criteria: none
progesterone-modified natural cycle for fet

Conditions: Infertility, Female

Summary: hormone replacement therapy (hrt) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (nc). by ensuring the presence of the corpus luteum while reducing the number of monitoring sessions, the progesterone modified natural cycle (p4mnc) offers more convenience for the patient than the normal nc. this study is designed to compare the effects of p4mnc and hrt cycles on fet outcomes.


Eligibility criteria:
inclusion criteria: * patients aged 21 to 44 years undergoing fbt * body mass index (bmi) 18-35 kg/m2 * having regular ovulatory cycles exclusion criteria: * untreated uterine adhesions * medical contraindications to estrogen and progesterone therapy * illnesses contraindicating assisted reproductive technology or pregnancy * history of recurrent implantation failures (\> 2 embryo transfer failures)

Keywords: progesterone-modified natural cycle hormone replacement therapy frozen-thawed embryo transfer
reducing asthma disparities by improving provider-patient communication

Conditions: Asthma

Summary: the purpose of this study will be to assess the impact of a culturally-sensitive, patient-focused asthma communication instrument (acci) designed to enhance provider-patient communication by prompting and guiding providers in assessments of disease severity and discussion of adherence behaviors with minority patients with asthma.

improving communication between health care providers and their patients is the critical first step in efforts designed to reduce asthma-related health disparities in urban areas. improving communication will help providers tailor asthma therapies to their patients' needs, and help providers and patients to overcome barriers (e.g., concerns about adverse effects) to adherence with those asthma treatment plans.

Eligibility criteria:
inclusion criteria: * are able to provide informed consent; * report physician-diagnosed asthma; * report asthma symptoms and/or use of short-acting reliever medication at least twice weekly in the past month. exclusion criteria: * state they do not have asthma; * have mild intermittent disease * no recent evidence of disease activity.

Keywords: asthma
the value of molecular residual disease monitoring based on ctdna in borderline resectable or locally advanced pancreatic cancer

Conditions: Pancreatic Cancer; Locally Advanced

Summary: the goal of this clinical trial is to explore the value of molecular residual disease (mrd) monitoring based on ctdna in borderline resectable or locally advanced pancreatic cancer. the main questions it aims to answer are: * prognostic value of baseline mrd; * the role of mrd dynamic changes after treatment in guiding treatment. peripheral blood derived from participants will be obtained for mrd test before conversion therapy initiation and at the first imaging assessment after chemotherapy.


Eligibility criteria:
inclusion criteria: * patients with histologically confirmed borderline resectable or locally advanced pancreatic cancer; * conversion therapy was planned; * both sexes, age ≥18 years old; * ecog performance status score ≤2; * the expected survival time was ≥3 months. exclusion criteria: * a known diagnosis of pancreatic cancer other than ductal adenocarcinoma; * treated with any systemic antitumor treatment before first-line chemotherapy onset; * died or lost to follow-up within one month after the initiation of first-line chemotherpay; * combined with other primary malignances.
effect of nitric oxide (no) on ischemic/reperfusion injury during extended donor criteria (edc) liver transplantation

Conditions: Liver Transplantation; Ischemia/Reperfusion Injury; Oxidative Injury

Summary: in this study, the researchers propose to investigate the efficacy of inhaled nitric oxide to prevent ischemia-reperfusion (i/r) hepatocyte injury in patients who receive extended donor criteria(edc)liver grafts based on changes in proteomic and metabolomic markers following revascularization of the donor graft. in reviewing the literature, no uniform extended criteria donor classification exists. the characteristics most associated with liver graft failure appear to be cold ischemia time greater than 10 hours, warm ischemia time greater than 40 minutes, donor age \> 55 years of age, donor hospitalization \> 5 days, a donation after cardiac death (dcd) graft, and a split graft. the researchers will exclude warm ischemia time as this is impossible to predict prior to the transplantation. any donor meeting at least one of the other criteria will be classified as an edc donor. hypothesis 1: inhaled nitric oxide will improve overall outcome of liver recipients after edc liver transplantation * suppression of oxidative injury will improve graft function postoperatively as measured by international normalized ratio (inr) bilirubin, transaminases, and duration of hospital stay. hypothesis 2: the mechanisms of therapeutic efficacy of inhaled nitric oxide is based on reduction in post-reperfusion oxidative injury as readily measured by the detectable changes in the protein and metabolic profiles in plasma of patients treated with inhaled-no * nuclear magnetic resonance (nmr)-based metabolic markers (xanthine end-products, lactate, and hepatic osmolytes) that are consistent with acute liver injury will be decreased in no-treated recipients. * protein markers of reperfusion injury (argininosuccinate synthase (ass) and estrogen sulfotransferase (est-1) will be greater in the plasma of patients who are not treated with inhaled-no * reduced oxidative injury will be reflected by a decrease in the number of mitochondrial peroxiredoxins isoforms and the number that are oxidized in no-treated liver recipients.


Eligibility criteria:
inclusion criteria: * age 18 - 69 years of age * moderate to severe liver disease (meld score 22 to 30) * is receiving a extended donor criteria liver graft exclusion criteria: * undergoing multi-organ transplant * 70 years or older * diagnosed with hepatocarcinoma * diagnosed with either hepatopulmonary syndrome or pulmonary hypertension * pregnant

Keywords: extended donor criteria
post-market registry in patients with iliac aneurysm undergoing endovascular stenting with the e-liac stent graft system

Conditions: Iliac Aneurysm

Summary: the purpose of the study is to evaluate the clinical and technical success as well as safety and feasibility of the e-liac stent graft system used in endovascular treatment of uni- or bilateral aortoiliac or iliac aneurysm. main study target is the exclusion of aneurysm with primary patency of the arteria iliaca interna and the arteria iliaca externa on iliac implantation side.


Eligibility criteria:
inclusion criteria: * patients must comply with the indications for use * unilateral or bilateral common iliac aneurysm diameter equal or greater 25mm * unsuitable distal sealing site within the common iliac artery for traditional evar exclusion criteria: * patients with a stenotic internal iliac ostium of \< 4mm in diameter * patients with severe internal iliac atherosclerosis * patients that do not have a suitable landing area in the main stem of the iia * patients with pseudoaneurysms * patients with symptomatic and ruptured iliac aneurysms * patients with one of the contraindications as indicated in the instructions for use * patients pretreated with a bifurcated vascular graft * patient with thrombocytopenia * patient with creatinine \>2.4 mg/dl immediately before the intervention * patient with malignancy needing chemotherapy or radiation * patients who are enrolled in another clinical study * patients with life expectancy of less than 36 months

Keywords: aneurysms vascular disease e-liac stent graft e-liac stent graft system iliac aneurysm branched stent graft self expanding stent graft
prognostic value of igm in covid-19 infection

Conditions: COVID-19

Summary: the primary objective of the research is to study the relation between the presence and /or the anti sars-co-v-2 igm level in an early stage of covid-19 infection, and the evolution of the illness.

the secondary objective is to determinate in what manner response of igm anti-sars-co-v-2 relates to patient's immunity statute, in regards to the other so-called humain "seasonal coronavirus".

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years; * have been diagnosed positive of sars-cov-2 in the virological laboratory of ambroise paré hospital; * have been blood sampled between 1 day and 14 days from the first clinical syndromes, and their collections of serum or plasma are conserved and accessible; * affiliated to the social security scheme or entitled; * informed and non-opposed to participating to the study. exclusion criteria: * opposition of patient to participation to the study; * foreign patients under french ame scheme.

Keywords: covid-19 anti sars-co-v-2 igm
gabapentin for headache in aneurysmal subarachnoid hemorrhage

Conditions: Aneurysmal Subarachnoid Hemorrhage

Summary: the purpose of this study is to see how much gabapentin will reduce headaches associated with subarachnoid hemorrhage (sah) and to reduce the amount of narcotic pain medication prescribed.

the investigators plan to use gabapentin (gbp), an fda approved non-narcotic pain medication for neuropathic pain, which is also an alpha-2-delta (a2dr) receptor analogue to reduce the pain and decrease the need for narcotics in patients with aneurysmal subarachnoid hemorrhage (asah). gbp has been shown to decrease neuropathic and non-neuropathic pain in a variety of perioperative and postoperative conditions. a2dr affinity also has some neuroprotective effect in animal data. the investigators plan to conduct a prospective, double-blinded, randomized trial to further assess gbp-associated reductions in narcotic use and pain scores compared to the non-gbp (placebo) arm. to accomplish this aim, the investigators plan to randomize 20 asah patients with headache to either gbp and standard of care pain treatment versus placebo and standard of care treatment.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. have aneurysmal subarachnoid hemorrhage (asah) diagnosed by ct scan of the brain and/or angiogram evidence of intracranial aneurysm (cta or digital subtraction angiogram or mra) 3. have symptomatic headache 4. able to swallow and verbalize pain score 5. no known allergy to gabapentin or fentanyl 6. numeric pain score ≥ 5 7. ability to provide written personal consent exclusion criteria: 1. gabapentin use prior to sah admission 2. renal failure with creatinine clearance less than 30 ml/min 3. unable to receive standard of care pain medications 4. pregnant or breastfeeding patients 5. history of severe depression defined by the diagnostic and statistical manual of mental disorders, 4th edition, text revision (dsm iv)

Keywords: asah sah
multilevel intervention based on colorectal cancer (crc) and cervical cancer self-screening in rural, segregated areas

Conditions: Colorectal Cancer Screening; Cervical Cancer Screening

Summary: in this study, the investigators will deliver self-sampling human papillomavirus (hpv) tests and fecal immunochemical test (fit) kits, as well as adapted cancer screening educational materials, by mail to 110 women who are out-of-date for both cervical and colorectal cancer screenings, recruited through federally qualified health centers (fqhcs) in rural, segregated counties of pennsylvania. the hypothesis is that delivering self-sampling hpv tests and fit, as well as adapted educational materials, to women in rural, segregated areas could help increase cancer screening, reduce geographic cancer disparities, and improve public health.

in this study, the investigators will deliver self-sampling human papillomavirus (hpv) tests and fecal immunochemical test (fit) kits, as well as adapted cancer screening educational materials, by mail to 110 women who are out-of-date for both cervical and colorectal cancer screenings, recruited through federally qualified health centers (fqhcs) in rural, segregated counties of pennsylvania. a control group of 110 women, also recruited through fqhcs in rural, segregated counties of pennsylvania, will be used for comparison; these women will receive standard-of-care reminders for cancer screening and complete the baseline and follow-up surveys. the hypothesis is that delivering self-sampling hpv tests and fit, as well as adapted educational materials, to women in rural, segregated areas could help increase cancer screening, reduce geographic cancer disparities, and improve public health.

Eligibility criteria:
inclusion criteria: * lives in rural, segregated county of pennsylvania * able to speak, read, and communicate well in english * out of date for both cervical and colorectal cancer screening exclusion criteria: * has had a partial or complete hysterectomy * has a family history of colorectal cancer * has a personal history of cervical or colorectal cancer * persons who are cognitively impaired * persons who are incarcerated

Keywords: environmental barriers to cancer screening person-level barriers to cancer screening
time-restricted eating and bipolar disorder

Conditions: Bipolar Disorder

Summary: this is a pilot trial to examine the acceptability and feasibility of time-restricted eating as an adjunct to medication treatment for bipolar disorder.

time-restricted eating (tre) is a way of scheduling food intake that has been shown to improve circadian rhythms in animals and humans. tre is based on animal and human science that shows that the timing of eating powerfully influences diurnal rhythms. animal research has shown that feeding during sleep periods leads to a surge of norepinephrine, cortisol, wakefulness, and activity. drawing on this, over a decade of studies have examined the impact of experimentally randomizing mice to time-restricted feeding during wake hours (vs. 24-hour ad libitum feeding). importantly, caloric intake and other facets of diet were yoked for strict control. a consistent finding is that tre had powerful benefits for circadian and metabolic indicators across studies,and more recent data also shows benefit for animal longevity. here, the investigators' goal is to extend this work to bipolar disorder (bd). more specifically, the investigators will gather data to examine the acceptability and feasibility of tre among those who self-identify with bipolar disorder and who experience some problems with sleep, circadian rhythms, or schedules. the investigators will gather measures of mania, depression, sleep, and qol, to provide preliminary evidence of change on these dimensions.

Eligibility criteria:
inclusion criteria: * adults diagnosed with bipolar disorder and currently receiving medical care for their bipolar disorder. * experiencing schedule/sleep or circadian problem in the past 3 months * medication regimens stable for past month * adequate english language skills for taking part in the program. * living in california. exclusion criteria: * cognitive deficits (screening omc test) * current: psychosis, (hypo)mania, major depressive episode, substance/alcohol use disorders, eating disorder diagnoses or acute suicidal risk (mini interview; see dsm5 tre screening) * high scores (\> 5) on the screening eating disorder examination questionnaire * current shift work * \>5 kg weight change within 3 months * pregnancy * breastfeeding * uncorrected hypo or hyperthyroidism \* diabetes type 1 * gastrointestinal conditions impairing nutrient absorption * medications contraindicated for fasting, including clozapine, glucose-lowering medications, diabetes-related injections, requiring food early morning or late evening, corticosteroids.

Keywords: eating circadian
perioperative residual adrenal function after extended resection for retroperitoneal soft tissue sarcomas

Conditions: Adrenal; Functional Disturbance; Retroperitoneal Sarcoma; Intraoperative Hypotension

Summary: early recognition of adrenal function deficit in patients undergoing multivisceral surgery including adrenalectomy for primitive retroperitoneal sarcomas

the extended multivisceral resection of retroperitoneum is the standard treatment for primary retroperitoneal soft tissue sarcomas. this procedure also includes the removal of the healthy adrenal gland ipsilateral to the tumor site. the investigators think that a such extended surgical approach together with the removal of the adrenal gland may lead to a state of acute adrenal insufficiency and related hemodynamic instability. in order to recognize this condition the investigators use a low dose acth test (synacthen test) during the 1° and 10° post-operative days.

Eligibility criteria:
inclusion criteria: * adult patients (age\> 18 years) * diagnosis of retroperitoneal sarcoma * adrenalectomy enbloc included in multivisceral resection * voluntary informed written consent exclusion criteria: * recurrent and / or metastatic disease * patient chronically treated with corticosteroids * primary disorders of adrenal gland * basal serum cortisol values ≤ 7 µg / dl * clinically significant heart disease * altered tsh

Keywords: retroperitoneal sarcoma surgery haemodynamic assessment adrenalectomy
ultrasound guided supraclavicular brachial plexus block, volume comparison of local anaesthetics and diaphragmatic motility.

Conditions: Sucessful Block With Less Hemidiaphragmatic Paresis in Distal Upper Arm Fracture

Summary: brachial plexus block as done by landmark technique use large volume of local anaesthetics (at least 30-40 ml), leading to higher incidence of phrenic nerve involvement and diaphragmatic dysfunction. with use of ultrasound dose of local anaesthetic can be reduced. volume as low as 20 ml when use by ultrasound guidance has shown to provide successful block with no hemidiaphragmatic palsy when compared with nerve stimulation technique. but no study has compared the different volumes of drug on success rate and diaphragmatic motility.so in this study , the investigators want to compare the incidence of hemidiaphragm paralysis and success of block with different volumes of local anaesthetic , so that the lowest effective dose with higher safety profile can be determined.


Eligibility criteria:
inclusion * age between 18 and 60 years undergoing distal arm surgery * american society of anesthesiologists physical status 1 to 3 * able to give informed consent * body weight greater than 50 kg exclusion * patient refusal for supraclavicular block. * inability to obtain informed consent. * contraindication to brachial plexus block * pulmonary and cardiac disorders * pregnancy * allergy to local anesthetic * chest or shoulder deformities
neurobiology of opioid dependence: 3 - 3

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to study the effects of cycloserine on naloxone-precipitated opiate withdrawal.


Eligibility criteria:
please contact site for information.

Keywords: opioid disorders
efficacy of natural extract 2007rd01 combined with saw palmetto in benign prostatic hyperplasia patients compared to saw palmetto

Conditions: Benign Prostatic Hyperplasia

Summary: the purpose of this study is to determine if the combination of 2007rd01, a natural extract, and saw palmetto lipidic extract, is more effective at treating lower urinary tract symptoms associated with benign prostatic hyperplasia than saw palmetto lipidic extract alone.


Eligibility criteria:
inclusion criteria: * patient must be an adult man aged between 50 and 75 * patient must have benign prostatic hyperplasia symptoms exclusion criteria: * patient has a malfunction of the urinary tract, is suffering from acute urinary retention, or is suffering from prostate cancer or urinary tract infection * patient has been subjected to surgery of the prostate, bladder or urethra * patient has taken a 5-alpha-reductase inhibitor in the 6-month period preceding screening * patient has taken an alpha-blocker in the 2-week period preceding screening

Keywords: prostate dietary supplements saw palmetto canada