Kornimate/medical-research-clean huggingface dataset:
spect investigation of the nmda receptor system in healthy volunteers and patients with schizophrenia

Conditions: Schizophrenia

Summary: this study was designed to compare the \[123\]i-cns 1261 binding to nmda receptor between healthy volunteers and different subgroups of schizophrenic patients. investigation of the potential influence of antipsychotic and concomitant medication on \[123i\] cns 1261 binding is also relevant.fifteen healthy subjects (male and female of non-child bearing potential) will be recruited and 40 schizophrenic patients divided in 3 subgroups as indicated before: subgroup a) treatment-naive, (n=10); subgroup b) on stable treatment with risperidone (without criteria of deficit syndrome on the sds scale, (n=15);subgroup c) on stable treatment with risperidone fitting criteria of deficit syndrome on the sds scale, (n=15).


Eligibility criteria:
inclusion criteria: * right-handed * smoker * healthy volunteer or schizophrenic patients as diagnosed by dsm iv criteria. * treatment naive patients or with risperidone treatment for 2 months that have not received any depot neuroleptic during the last year. * women of childbearing potential must agree to acceptable method of birth control. exclusion criteria: * any clinically or laboratory significant abnormality. * subjects receiving a radiation dose from other activities of more than 10 msv over any 3 year period. * heart pacemaker, metallic prosthesis or other metallic body implants. * history or presence of cns conditions. * history of substance dependence. * history of or suffers from claustrophobia. * positive test for hbv (hepatitis b virus), hcv (hepatitis c virus) or hiv. * pregnant or lactating women.

Keywords: schizophrenic patients spet nmda receptor ligand [123]i-cns 1261
impact of an educational video on satisfaction after glaucoma surgery

Conditions: Glaucoma

Summary: overall objective: this study will assess whether an educational video is effective in increasing patient satisfaction with glaucoma surgery. 1. investigate the impact of educational interventions on glaucoma patients' surgical satisfaction. 2. investigate the post-operative satisfaction of rural glaucoma patients in county hospitals 3. investigate the difference in postoperative satisfaction between urban and rural glaucoma patients in urban hospitals 4. investigate other factors that influence postoperative glaucoma satisfaction.

glaucoma is the leading cause of irreversible blindness in china, as elsewhere in the world. in chinese rural settings, where topical glaucoma medication is unlikely to be a practical and sustainable option, surgery is the primary treatment modality for glaucoma. however, it is known that vision is quite likely to decline in the short to medium term after glaucoma surgery, and there are concerns that dis-satisfaction resulting from such vision changes might lead to negative social marketing, affecting uptake not only of glaucoma surgical care but other eye operations (principally cataract) as well. we propose to test the impact on post-operative satisfaction of a multi-media educational intervention designed to give patients a realistic expectation of their post operative course: glaucoma surgery is being performed not to improve vision, but do protect it from future harm, and vision may in fact decline for several weeks post operatively. a randomized controlled design will be used, and subjects undergoing glaucoma surgery will be enrolled at 4 rural county hospitals in rural guangdong province, and randomized to receive the intervention or usual care. the principal outcome will be subjective satisfaction on a previously-tested questionnaire instrument, administered pre-operatively and post-operatively on two occasions in the first month following surgery. patients not returning post-operatively to the surgical facility will be contacted by telephone for administration of the questionnaire. other facility- and patient-related clinical and personal factors expected to influence satisfaction will also be recorded, and adjusted for in all analyses.

Eligibility criteria:
inclusion criteria: * age≥18 years, glaucoma patients who do the peripheral iridectomy or trabeculotomy exclusion criteria: * patients who had been the trabeculotomy, vision≤0.05, severe psychotic disorders and dysgnosia

Keywords: glaucoma surgery educational intervention satisfaction rural
behçet and ldh/albumin

Conditions: Behcet's Disease; Albumin; Lactate Dehydrogenase; Disease Severity

Summary: abstract objective: to investigate whether the lactate dehydrogenase to albumin ratio can be used as a parameter to determine disease severity in behçet's disease, an inflammatory disease, by comparing it to healthy controls. patients and methods: in this retrospective cohort study, patients with behçet's disease aged 18-69 years who presented to the outpatient clinic between february 2020 and april 2023 and healthy individuals of similar age and gender were enrolled. ldh, albumin levels, and ldh/albumin ratio of both groups were compared. clinical findings and characteristics of behçet's patients and disease severity were recorded and analyzed in relation to ldh/albumin ratio.


Eligibility criteria:
inclusion criteria: patients with behçet's disease aged 18-69 exclusion criteria: * younger than 18 years or older than 69 years, pregnant and lactating patients, patients with acute infection on admission or nutritional problems, symptomatic gastrointestinal symptoms, malignancy, hepatitis or liver disease were excluded.
arabic pro measures for head and neck cancer radiotherapy.

Conditions: Head and Neck Cancer; Head and Neck Neoplasms; Head and Neck Squamous Cell Carcinoma; Oropharynx Cancer; Nasopharyngeal Cancer; Oral Cancer; Tongue Cancer; Oral Neoplasm

Summary: the goal of arabic patient-reported outcome measures during radiotherapy for head and neck cancer is to test the patient-reported outcome measure (prom) tools. prom tools are not validated cross-culturally in arabic-speaking patient populations, which limits their use in our clinical setting. validation of these prom tools will allow clinicians to identify the concerns related to our patient population and measure the outcome of our interventions. main objectives are: * to further validate (cross-culture) the prom instruments related to head and neck cancer (hnc) in arabic patients. * to investigate the prevalence and severity of the patient-reported concerns and their relevance with demographics and clinical characteristics. the participants will be given tasks to complete 6 tools survey before, during, and after radiotherapy.


Eligibility criteria:
inclusion criteria: * adults aged 18 or above and who is planned for receiving and who is currently receiving and who had already received radiotherapy for the hnc at king saud university medical city. exclusion criteria: * individuals who are less than 18 years, presence of debilitating disease (e.g. heart failure) or who lack the capacity to read, understand and sign the informed consent and those.

Keywords: proms head and neck cancer radiotherapy cosmin cancer
comparison of permethrin and ivermectin in children greater than 6 yrs age for treatment of scabies

Conditions: Scabies

Summary: scabies is highly contagious,pruritic infestation of skin.various treatment modalities have been used but search for ideal scabicide is ongoing.we wnt to coduct this study to compare the outcome of permethrin verses ivermectin in children for treatment of scabies .this randomized clinical trial will be done in children hospital lahore for 12 months.sample size of 90 cases;30 in each group will be included through non probability consecutive sampling.then patient will be randomly divided into 3 groups.in group a patient will be given 5% permethrin topical application to whole body single application. in group b ,patients will be given topical permethrin for twice application 24 hrs appart ,in group c patients will be given tablet ivermectin single dose 200microgram/kg.then patients will be examined after 2 weeks and 4 weeks for no of lesions and pruritis and cure will be labeled.all this information will be recorded on performa .data will be entered and analysed by using spss version 26.three groups will be compared for cure by using chi-square test.p value less than and equal to 0.05 will be considered as significant.


Eligibility criteria:
inclusion criteria: * age 6-15 * both genders * diagnosed with scabies (as per operational definition) exclusion criteria: * children with recurrent scabies on medical record * known allergy to ivermectin or permethrin. * widespread eczema or impetigo. * liver dysfunction or renal failure

Keywords: comparison of permethrin and ivermectin in scabies
pharmacogenetic study of methylphenidate in attention deficit/hyperactivity disorder(adhd)

Conditions: Attention Deficit Disorder With Hyperactivity; Methylphenidate; Pharmacogenetics

Summary: the noradrenergic system plays a known role in attentional systems and suspected causal role in attention deficit/hyperactivity disorder(adhd).methylphenidate also has been suspected as a inhibitor of norepinephrine transporter(slc6a2). the investigators hypothesis is that norepinephrine transporter polymorphism is associated with responses and adverse effects of oros-methylphenidate in treatment of adhd.


Eligibility criteria:
inclusion criteria: * adhd * physically healthy exclusion criteria: * neurological illness * concurrent additional psychiatric treatment * \< iq 70 * psychotic disorder * major mood disorder needed other psychiatric medication * significant suicidal ideation * pervasive developmental disorder

Keywords: adhd, norepinephrine transporter pharmacogenetics
covid infection in pediatric surgical patient

Conditions: COVID-19

Summary: children infected with covid-19 are mostly asymptomatic. there is a dearth of data on the epidemiology of covid-19 in the pediatric population. this is a prospective observational clinical study of pediatric surgical patients. covid-19 rapid antigen testing will be performed on pediatric patients.

children infected with covid-19 are mostly asymptomatic or mildly symptomatic. children may spread covid-19 to the elderly, vulnerable patients and medical staff. there is a dearth of data on the epidemiology of covid-19 in the pediatric surgical population. rapid antigen detection tests for the diagnosis of covid-19 are reliable, simple, fast, and inexpensive. this is a prospective observational clinical study. the study population will include all consenting pediatric surgical patients, aged 2-17 years. informed consent will be obtained from each patient and the legal guardian who agree to participate in the study. nasopharyngeal swab specimens will be collected from anesthetized pediatric patients. covid-19 rapid antigen testing will be performed according to the equipment manufacturer's instructions. data collection will include covid-19 test result, nasal swab complication, patient demographics, surgical history, medical history, regular medications, covid-19 symptoms, and covid-19 exposure information. covid-19 symptoms that will be recorded are cough, wheeze, nasal congestion, breathing difficulty, new loss of taste or smell, fever, chills, rigors, body aches, sore throat, nausea, and fatigue. covid-19 exposure will be considered as being within 6 feet of a person with diagnosed covid-19 infection in the previous 14 days.

Eligibility criteria:
inclusion criteria: * surgical patients aged 2-17 years * informed consent for surgery * no covid-19 diagnosis in previous 6 months * no history of nasal bleeding * no history of coagulopathy. exclusion criteria: * patient refusal of testing * difficulty in obtaining consent * covid-19 diagnosis in recent 6 month * history of nasal bleeding * history of coagulopathy.
patient agenda setting and clinic efficiency in outpatients

Conditions: Respiratory Tract Diseases

Summary: the purpose of the study is to determine whether patients who use a prompt sheet to identify their important issues before they see a doctor are more likely to feel that their important issues have been discussed during their consultation. the study will be conducted in a respiratory outpatient clinic.

evidence suggests that most patients come to a consultation with issues they wish to raise, but they may not actually raise them and clinicians may not elicit them. this can adversely affect the consultation outcome, e.g. through misunderstandings, unwanted prescriptions, non-adherence and unnecessary follow-ups. in a review of methods used before consultations to help patients address their information needs kinnersely et al. (2009) found that there were small but statistically significant increases in patient satisfaction and the number of questions patients asked, and no effect on consultation length. however, they identified several gaps in the evidence including the need to assess a wider range of outcome measures, to identify the impact of the methods on the types of questions asked and the need to measure consultation length accurately. this study aims to assess the impact of a written agenda form in a respiratory outpatient clinic. the form prompts the patient to identify their questions and issues, provides a list of frequently asked questions and invites the patient to write down the issues they wish to discuss with their doctor. we wish to identify whether use of the form increases the extent to which patients perceive that their important issues are discussed in the consultation. we will also assess whether patients feel more able to raise these issues and get the outcome they wanted, their confidence to manage their condition and consultation length. the study is a randomised controlled trial (rct) with a sample size of 158 patients. on arrival at the clinic patients will be randomly allocated to either the intervention group (who will receive an agenda form) or to standard practice. patient reported outcomes will be collected after the patient has seen the doctor and consultation times will be recorded by an independent observer outside the consultation room.

Eligibility criteria:
inclusion criteria: * have an outpatient appointment at one of the designated clinics * are able to understand the patient information sheet and complete the agenda form and the feedback form, or are accompanied by a person who meets this criteria and who is willing to complete the form on the patient's behalf * willing and able to give informed consent for participation in the study exclusion criteria: * no further criteria apply

Keywords: outpatient clinics, hospital humans outcome assessment (health care) patient outcome assessment patient satisfaction hospitalists secondary care
effectiveness of chest physiotherapy in infants with acute viral bronchiolitis

Conditions: Viral Bronchiolitis

Summary: the purpose of this study is to verify the effectiveness of chest physiotherapy (actual versus conventional) on respiratory distress in infants with acute viral bronchiolitis.

the infants were random in three groups: conventional techniques, actual techniques and suction of upper airways on the first two groups the infants were evaluated on admission,48,72hours and before hospital discharge. on third group was evaluated only on admission when srv was collected. respiratory distress was evaluated with wang's score by the physiotherapists and nurses not participating in the research.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute viral bronchiolitis * rsv positive exclusion criteria: * heart diseases * chronic lung disease * neurological diseases * parental refusal * previous wheezing episode * ventilatory support

Keywords: chest physiotherapy
reduced dissemination of tumor cells with primary ligation of the vein in patients with lung cancer

Conditions: Lung Cancer; Surgery; Circulating Tumor Cell

Summary: the purpose of this study is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood circulating tumor cells.

circulating tumor cells (ctcs) in the peripheral blood can be a biomarker to predict tumor recurrence and survival. handling the tumor during a surgery may promote the release of ctcs into the bloodstream. therefore, in a surgery of cancer, interruption of the vein before ligation of the artery may be justified. this multi-center randomized controlled trial is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood ctcs.

Eligibility criteria:
inclusion criteria: 1. patients with stage i-iv lung cancer eligible for surgery 2. patients undergoing the completely thoracoscopic lobectomy 3. the nodule size was more than 2.5 cm 4. patients consenting for intraoperative blood sampling exclusion criteria: 1. patients who underwent primary wedge resection and open lobectomy 2. patients who received neoadjuvant therapy before surgery

Keywords: lung cancer surgical technique vessel ligation circulating tumor cell
identification of prognostic factors and new therapeutic targets in cutaneous lymphomas

Conditions: Cutaneous Lymphoma

Summary: cutaneous lymphomas are a heterogeneous group of extra-nodal lymphomas. the prognosis of cutaneous lymphomas is extremely variable from one subject to another. in the majority of cases, there is no cure for cutaneous lymphomas. cutaneous lymphomas primarily affect the skin, and secondarily the blood, lymph nodes and possibly other organs. the discovery of new molecular prognostic factors will allow a better identification of patients at high risk of aggressive evolution and the implementation of a personalized therapeutic strategy. the identification of new therapeutic targets is necessary in order to develop new innovative treatments for cutaneous lymphomas.the primary objective is to identify novel molecular prognostic factors associated with 5-year overall survival in cutaneous lymphoma.


Eligibility criteria:
inclusion criteria: * age\> 18 years old * informed consent signed by the patient * suspicion of primary cutaneous lymphoma or confirmed lymphoma according to who/iscl/eortc criteria exclusion criteria: * patient under guardianship or curatorship * lack of affiliation to social security
association between vitamin d and the development of uterine fibroids

Conditions: Gynaecological Disease; Vitamin D Deficiency

Summary: the aim of this randomised clinical trial study is to evaluate whether supplementation with vitamin d could inhibit the growth of uterine fibroids in reproductive stage women.

180 patients with vitamin d deficiency (12 ng/ml ≤ serum 25-hydroxyvitamin d3 \< 20 ng/ml) and uterine fibroids will be randomly assigned in a ratio of 1:1 to two groups: intervention group a and control group b. 180 patients with vitamin d insufficiency (20 ng/ml ≤ serum 25-hydroxyvitamin d3 \< 30 ng/ml) and uterine fibroids will be also randomly assigned in a ratio of 1:1 to two groups: intervention group c and control group d. the intervention group a will receive 1600 iu/d of vitamin d3; the intervention group c will receive 800 iu/d of vitamin d3; the control group b and the control group d will receive regular follow-up. patients will be followed up at the same time points for 24 months. the outcome measure is the growth of uterine fibroids in different groups.

Eligibility criteria:
inclusion criteria: * 1. patients are willing to cooperate with the follow-up and sign informed consent; * 2. females aged 35-50 who are diagnosed as having uterine fibroids by transvaginal or abdominal ultrasonography; * 3. the maximum average diameter of intramural myoma is ≤ 4cm，≥ 1cm; the amount of myoma is less than 4; * 4. serum 25-hydroxyvitamin d3 \< 30 ng/ml, ≥ 12 ng/ml. exclusion criteria: * 1. patients with heavy menstrual bleeding (\>80.0 ml), menstrual disorders, pelvic discomfort, infertility, or other indications for operation; * 2. patients complicated with myoma degeneration and adenomyosis that were suspected or diagnosed by ultrasound or gynecologic examination; * 3. allergic to vitamin d3; * 4. use of sexual hormone, mifepristone, gonadotropin-releasing hormone agonist (gnrha), or other medication which is likely to interfere with uterine fibroids within 3 months; * 5. pregnancy, lactation, postmenopause, or planned pregnancy within two years; * 6. suspected or identified as other tumors of genital tract; * 7. history of osteoporosis or vitamin d deficiency taking vitamin d supplements within previous one month; * 8. history of autoimmune diseases, infectious diseases (tuberculosis, aids), autoimmune diseases, digestive system diseases (malabsorption, crohn disease, and dysentery); * 9. alanine aminotransferase (alt) or aspartate transaminase(ast) more than 3 times of the normal upper limit, total bilirubin (tbil) more than 2 times of the normal upper limit; * 10. creatinine levels≥1.4 mg/dl (123μmol/l) or creatinine clearance ≤ 50 ml/min; * 11. history of malignant tumors; * 12. simultaneous participation in another clinical study with investigational medicinal product(s) or researcher thinks the subjects are not suitable for this trial.
onco-haematology vigilance card

Conditions: Medical Oncology; Hematology; Molecular Targeted Therapies

Summary: the objective of this study is to show the interest of setting up a drug vigilance card in oncology in order to reinforce patient safety, develop compliance and avoid drug interactions when the patient consults town professionals or other specialists.

recent developments in oral chemotherapy and targeted therapies have radically changed cancer patient management; ambulatory care is now common. oral therapies afford many advantages, improving patient quality of life and autonomy by reducing hospital stays and involving patients in their own care. optimising the care of cancer patients at home requires the coordinated intervention of hospital and town healthcare professionals and involvement of the patient to detect, prevent, and manage adverse events, avoid drug interactions, and educate patients. preliminary work in haematology has highlighted (n = 31 patients) the interest of a "drug vigilance card" in three indications (chronic lymphocytic leukaemia, chronic myeloid leukaemia and multiple myeloma) with an increase in the town-hospital link. this is an prospective cohort study. following the announcement consultation, in addition to the personalised care plan, the information about the treatment will be contained in a drug monitoring card that will be given to the patient by the health professional (doctor or nurse). this drug monitoring card should be presented to the health professionals by the patient. during the entire period of treatment, the patient will have a card.

Eligibility criteria:
inclusion criteria: * all patients treated at limoges university hospital in medical oncology department, receiving oral treatment (chemotherapy and/or targeted therapies) exclusion criteria: * all patients treated at limoges university hospital in medical oncology department, receiving hormone therapy or iv treatment only.