Kornimate/medical-research-clean huggingface dataset:
the utility of psadv (psa density velocity) while on dutasteride for predicting prostate cancer incidence and grade and stage

Conditions: Prostate Cancer

Summary: this is a review of previously published data from a large prostate cancer prevention study known as reduce. it is the investigators intention to review whether prostate specific antigen (psa) velocity (change over time) will predict the presence of prostate cancer and its grade and stage (severity).

this is a review of previously published data from a large prostate cancer prevention study known as reduce that utilized a 5 ari, dutasteride. it is the investigators intention to review whether psa velocity (change over time) will predict the presence of prostate cancer and its grade and stage (severity) by two year biopsy. the investigator will review and compare data to a previously published study of similar design with finasteride.

Eligibility criteria:
inclusion criteria: * men, * 50-74 years old with elevated psa (\>=4) along with negative entry biopsy of the prostate who had a subsequent biopsy by 24 months. exclusion criteria: * any positive biopsy of the prostate indicative of cancer upon entry

Keywords: psa density prostate cancer prostate biopsy psa
clinical comparison of different flowable resin composites

Conditions: Tooth Diseases

Summary: the aim of this study is to evaluate a self-adhesive flowable resin composite, a flowable resin composite with high viscosity and a conventional flowable resin composite in combination with a universal adhesive using two different application modes. all patients will receive at least 4 occlusal restorations. cavities will be divided into four groups according to restorative systems used: constic (a self-adhering flowable composite), g-ænial universal flo (a highly filled flowable composite), tetric n-flow (self-etch) (a conventional flowable composite), tetrin n-flow (etch\&rinse).


Eligibility criteria:
inclusion criteria: * having no medical or behavioral problems preventing then from attending review visits * absence of previously placed restorations * having antagonist teeth exclusion criteria: * poor gingival health * uncontrolled, rampant caries * bruxism * removable partial dentures * xerostomia

Keywords: flowable resin composite occlusal
favipiravir therapy in adults with mild covid-19

Conditions: COVID-19

Summary: favipiravir is a selective and potent inhibitor of inﬂuenza viral rna polymerase. it acts as a purine analogue, which selectively inhibits viral rna-dependent rna polymerase (rdrps). it has the characteristic of acting on rna viruses including ebola and coronaviruses especially novel coronavirus (2019-ncov). the purpose of this study is to evaluate the clinical efficacy and safety of favipiravir in comparison to placebo in the treatment of mild covid-19 cases. it is a multicenter, randomized double-blinded, parallel-group trial.


Eligibility criteria:
inclusion criteria patients must be eligible according to the following criteria for enrollment 1. should be at least 18 years of age 2. male or non-pregnant female (pregnancy testing is not mandatory. if the patient requests or is not sure, the study team will provide it) 3. diagnosed with mild covid-19\* confirmed by positive pcr test for sars-cov-2 at the time of recruitment, a result within the last five days 4. patients have to be enrolled within 5 days of disease onset. exclusion criteria patients meeting any of the following criteria will be excluded from trial enrolment: 1. patients with concomitant documented bacterial pneumonia established through positive sputum cultures 2. patients who are pregnant or breastfeeding 3. known sensitivity/allergy to favipiravir (if faviparavir was used for covid-19 in the patient previously for influenza) 4. major comorbidities increasing the risk of study drug including * hematologic malignancy * advanced (stage 4-5) chronic kidney disease or dialysis therapy * severe liver damage (child-pugh score c, ast\> 5 times the upper limit) * hiv * gout/history of gout or hyperuricemia (two times above the uln) (6) having used favipiravir or participated in any other interventional drug clinical study within 30 days before the first dose of study drug (i.e., the patient received it for influenza previously) (7) the investigator believes that participating in the trial is not in the best interests of the patient, or the investigator considers unsuitable for enrollment (such as unpredictable risks or subject compliance issues) (8) clinical prognostic non-survival, palliative care, or in a deep coma and have no response to supportive treatment within three hours of admission. (9) hospitalized patients for mild, moderate, or severe covid-19

Keywords: favipiravir covid19 mild illness saudi arabia
inhaler technique training

Conditions: Asthma Chronic; Obstructive Pulmonary Disease

Summary: the evidence for poor inhaler technique is both well established and observed worldwide. what is unclear from the evidence is why individuals demonstrate poor technique, despite the majority admitting to having previously had instruction on inhaler technique. the primary research question is 'will there be a difference between post education inhaler technique scores when comparing structured education against informal education?' to try and establish why individuals use inhalers incorrectly a semi structured interview is proposed


Eligibility criteria:
inclusion criteria: * inclusion criteria will be anybody whose regular treatment requires inhaled medication. they will be included regardless of age, disease, inhaler device used or cognition. exclusion criteria: * the only exclusion criteria will be if a willing participant is not on an inhaler of any type.
ziprasidone and olanzapine's outcomes in mania

Conditions: Acute Mania; Bipolar Disorder, Manic

Summary: the purpose of this study is to compare the efficacy and tolerability of ziprasidone versus olanzapine in the treatment of acute mania. an open label extension will further evaluate the efficacy, safety, and tolerability of ziprasidone compared with olanzapine. study recruitment was stopped due to difficulty in enrolling the targeted number of patients on july 30, 2007. subjects that were enrolled at the time completed the study as per protocol. there were no safety concerns involved in the decision to stop enrollment. the last subject last visit was january 10, 2008.


Eligibility criteria:
inclusion criteria: * have a primary diagnosis of bipolar i disorder, current episode manic (dsm-iv 296.4x) or mixed (dsm-iv296.6x) as determined by a structured clinical interview (mini international neuropsychiatric interview (mini)) at screening. * a minimum score of 20 on the ymrs (youngs mania rating scale). exclusion criteria: * have a diagnosis of learning disability or organic brain syndrome. * have a substance-induced psychotic disorder or behavioral disturbance thought to be due to substance abuse.
reversible cerebral vasoconstriction syndrome with concomitant transient global amnesia

Conditions: Transient Global Amnesia; Reversible Vasoconstriction Syndrome

Summary: reversible cerebral vasoconstriction syndrome (rcvs) is characterized by severe, unusual headaches associated with multifocal segmental vasoconstriction of the intracerebral arteries. in addition to headache, focal neurological deficit and/or seizures are quite frequently described, but anterograde amnesia seems to but extremely rare. indeed, to date, only one case of rcvs associated with transient global amnesia (tga) has been published. in case of an atypical presentation of tg, associated with brutal headaches, it is important not to ignore an assocation with rcvs because management, treatment, evolution and prognosis are different. indeed, tga is a monophasic phenomenon of less than 24 hours duration, without associated complications, which does not require any particular treatment. on the other hand, rcvs, although most often of excellent prognosis, can have severe complications such as intracerebral hemorrhage, subarachnoid hemorrhage, posterior reversible encephalopathy syndrome and cerebral infarction. in order to limit headaches and potential complications, rcvs require special management, including symptomatic treatments for headaches, complete rest, removal of precipitin factors and introduction of calcium channel blockers for a few weeks. this study aim to described three cases of patient who presented with concomitant tga and rcvs, and to discuss pathogenic mechanism which may be similar in both these pathologies.


Eligibility criteria:
inclusion criteria: * patients with a proven or probable rcvs concomitant with certain transient global amnesia exclusion criteria: * not proven transient global amnesia, not proven or possible rcvs

Keywords: thunderclap headache
safety and efficacy of gaseous nitric oxide on venous stasis leg ulcers

Conditions: Venous Ulcers

Summary: the purpose of this study is to determine whether nitric oxide (no)gas is effective in the treatment of venous ulcers of the lower leg.

subjects were divided into two groups - one receiving 200ppm no gas delivered topically to the wound area for 8 hours a day for 6 weeks. the other group (control arm) received standard of care (compression) for 22 weeks.

Eligibility criteria:
inclusion criteria: * must have given written informed consent and hipaa authorization * must be ≥ 18 years of age * must have a venous ulcer for 60 days or greater * abpi \> 0.8 and ≤ 1.2 * must have ulcer between 3cm2 and 25cm2 in size exclusion criteria: * has an ulcer that is deemed by the investigator to be caused primarily by a medical condition other than venous insufficiency * bmi ≥ 35 * has evidence of clinical infection * suffers from diabetes mellitus with hba1c ≥ 8% * suffers from clinically significant arterial disease * has a known allergy to any of the compounds / drugs that are part of this protocol * has evidence of the ulcer and / or infection extending to the underlying muscle, tendon or bone * has used any investigational drug(s) within 30 days preceding randomization * is unable to manage self-treatment * is pregnant, nursing mother or a woman of child bearing potential who is not using an adequate form of contraception (or abstinence) * suffers from a condition which in the opinion of the investigator would compromise the safety of the subject and / or the quality of the data * is using any of the prohibited concomitant medications or treatments * has previously participated in this study

Keywords: venous leg ulcer
wellness tool in anesthesia providers

Conditions: Burnout, Professional; Occupational Stress; Affective Symptoms

Summary: this study will examine the effects of isha kriya meditation on stress and burnout among healthcare providers.

in this study, investigators will evaluate the effect of isha kriya meditation on stress and burnout among perioperative healthcare providers. to do this, investigators will randomize healthy participants to one of two groups: one who will meditate twice daily for six weeks (group 1), and the other who will not meditate for first six weeks and then meditate for another six weeks (group 2). investigators will then evaluate stress and burnout using validated electronic instruments at baseline and at six weeks for group 1 and at baseline, six weeks, and 12 weeks for group 2.

Eligibility criteria:
inclusion criteria: * age ≥18 years * perioperative healthcare provider exclusion criteria: * low english proficiency * currently enrolled in another interventional study that could impact the primary outcome, as determined by the principal investigator * not currently residing in the united states
antithymocyte globulin and cyclosporine in treating patients with myelodysplastic syndrome

Conditions: Myelodysplastic Syndromes

Summary: the main objective of this trial is to evaluate the efficacy and toxicity of intensive immuno-suppression with atg + csa versus best supportive care in patients with transfusion dependent low and intermediate risk myelodysplastic syndrome (mds).

this trial will answer the question whether immuno-suppression improves hematopoesis and reduces transfusion requirements analogous to patients with aplastic anemia as the short-term outcome, and whether immuno-suppression accelerates leukemic transformation and influences survival as the long-term outcome. primary endpoint: best response (cr + pr) rate at month 6

Eligibility criteria:
hypoplastic mds, or mds subtype ra, ras or raeb with ≤ 10% blasts, or raeb with 10-20% blasts and the patient refusing or not eligible for the mds high risk protocol (eortc 06961) * transfusion dependence \< 24 months or neutrophils \< 0.5 × 109/l. * ecog/sakk performance status ≤ 2 * age \> 18 years * no active uncontrolled infection * no prior chemotherapy or radiotherapy * no history of heart failure, clinically relevant cardiac arrhythmia or other hemato-oncological disease

Keywords: refractory anemia refractory anemia with ringed sideroblasts refractory anemia with excess blasts de novo myelodysplastic syndromes previously treated myelodysplastic syndromes secondary myelodysplastic syndromes
study on the use of artificial intelligence (fujifilm) for polyp detection in colonoscopy

Conditions: Screening Colonoscopy; Colonoscopic Control After Polypectomy; Suspected Colon Polyps

Summary: colonoscopy is currently the best method of detection of intestinal tumors and polyps, particularly because polyps can also be biopsied and removed. there is a clear correlation between the adenoma detection rate and prevented carcinomas, so adenoma detection rate is the main parameter for the outcome quality of diagnostic colonoscopy. the efficiency of preventive colonoscopy needs optimisation by increase in adenoma detection rate, as it is known from many studies that approximately 15-30% of all adenomas can be overlooked. this mainly applies to smaller and flat adenomas. however, since even smaller polyps may be relevant for colorectal cancer development, the aim of colonoscopy should be to preferably be able to recognize all polyps and other changes.the latest and by far the most interesting development in this field is the use of artificial intelligence systems. they consist of a switched-on software with a small computer connected to the endoscope processor; the patient's introduced endoscope is completely unchanged. the present study therefore compares the adenoma detection rate (adr) of the latest generation of devices with high-resolution imaging from fujifilm with and without the connection of artificial intelligence.

methods of computer vision (cv) and artificial intelligence (ai) provide completely new opportunities, e.g. in the automatic polyp detection and differentiation of a lesion based on its endoscopic image. computer vision using artificial intelligence methods means the application of "trained" so-called deep neural net (dnn) with a set of defined images (e.g. everyday scenes) and well-known solutions ( e.g. name of the pictured item; c.f. e.g. the "imagenet challenge"). the technical feasibility of using ai algorithms in endoscopy has already been proven in many cases. in the present study, it is an ai system from fujifilm, which is already clinically usable. by using fujifilm high-resolution imaging devices in colonoscopies, ai will be added randomly.

Eligibility criteria:
inclusion criteria: * persons\> 35 years of age who are capable of giving informed consent * planned diagnostic colonoscopy (clarification of symptoms, polyp follow-up) * screening colonoscopy for men \>50 or women \> 55 years of age exclusion criteria: * colon bleeding * colon carcinoma * known polyps for removal * inflammatory bowel disease * colonic stenosis * other suspected colon disease for further clarification * follow-up care after colon cancer surgery (partial colon resection) * anticoagulant drugs that make a biopsy or polypectomy impossible * poor general condition (asa iv) * incomplete colonoscopy planned
comparing the prognosis of patients with cardia and non-cardia gastric cancer.

Conditions: Gastric Cancer

Summary: to comparing the stage-for-stage prognosis of patients with cardia and non-cardia gastric cancer after operation.

the aim of this study is to compare the stage-for-stage prognosis of patients with cardia and non-cardia gastric cancer after operation.in this study, patients with cardiac and non-cardiac gastric cancer who undergo radical resection from january 2019 to december 2024 will be included. we will follow up the patient's progression, recurrence time and survival time.

Eligibility criteria:
inclusion criteria: 1. histopathology or cytopathology proven cardia or non-cardia gastric cancer; 2. operable gastric cancer patients: primary lesions can be completely excision, no distant metastasis; 3. life expectancy of at least 6 months; 4. ecog（eastern cooperative oncology group ） score 0-1; 5. age: 18\~80 years old; 6. normal hemodynamic indices before the recruitment (including blood cell count and liver/kidney function). for example: wbc（white blood cell count ）\>4.0×109/l; neu（neutrophils）\>1.5×109/l; plt（platelet）\>100×109/l; 7. roughly normal cardiopulmonary function: no coronary heart disease, myocardial infarction, pulmonary heart disease, refractory hypertension; 8. not concomitant with other uncontrollable benign diseases before the recruitment; 9. voluntarily signed the informed consent. exclusion criteria: 1. advanced gastric cancer patients with distant metastasis and inoperable ; 2. pregnant or lactating women; 3. patients who have no desire to participate in the study.

Keywords: cardia gastric cancer non-cardia gastric cancer resection prognosis
effect of cognitive behavioral therapy on chronic low back pain with sensitization

Conditions: Chronic Low Back Pain; Central Sensitisation

Summary: purpose: the main objectives of the study are: 1. to find the efficacy of using cognitive behavioural therapy on chronic low back pain with central sensitization. 2. to assist in planning an ideal physical therapy rehabilitation program for these patients. background: recent research has shown that clbp is a multifactorial disorder comprising psychosocial factors like pain catastrophization, fear avoidance and central sensitization. central sensitization has been defined as "an amplification of neural signaling within the central nervous system that elicits pain hypersensitivity", and "increased responsiveness of nociceptive neurons in the central nervous system to their normal or subthreshold afferent input". maladaptive behavior, false beliefs and misinformation regarding the cause of the pain are all contributing factors to the chronicity of lbp. central sensitization has been attributed to cortical reorganization and amplification of the somatosensory representation of the back causing increased pain and further contributing to the maladaptive behavior and beliefs. cognitive behavioral treatment has been an important intervention for psychological disorders for decades and recently has gained a lot of interest as an intervention for chronic pain in general and clbp in specific. hypotheses: it will be hypothesized that: cognitive behavioural therapy will have a significant effect on centrally sensitized pain intensity and disability. research question:" does cognitive behavioral therapy have a significant effect on chronic low back pain with central sensitization"


Eligibility criteria:
inclusion criteria: 1. age between 18- 50. 2. patient must have experienced low back pain for at least 3 months. 3. patient must have a score above or equal 40 in the central sensitization inventory (csi) (neblett r. c., 2013) (neblett r, 2015) (neblett h. m., 2016) (r. de pauw, 2015) (mayer tg n. r., 2012) . 4. patient must have a score of 3 and above on the numerical pain rating scale. exclusion criteria: * patients were excluded if they had taken pain medications on the day of the assessment. * patient who had serious spinal pathologies, such as fractures, tumors or inflammatory diseases, such as ankylosing spondylitis, narrowing of spinal canal and other conditions or severe cardiorespiratory diseases. * uncontrolled mental health condition that prevents successful compliance.

Keywords: cognitive behavioural therapy flexion relaxation phenomenon electromyography biofeedback functional training
early surgical intervention combined with weight-supported walking training

Conditions: Spinal Cord Injuries

Summary: to determine the efficacy of a novel combinatorial treatment involving early surgical intervention and long-term weight-bearing walking training in spinal cord injury (sci) patients clinically diagnosed as complete or american spinal injury association impairment scale class a (ais-a).

in the present study, the investigators reported the efficacy of a novel combinatorial approach involving early surgical intervention and long-term weight-bearing walking training in sci patients clinically defined as complete or ais-a. the surgical intervention involves the intradural decompression (via durotomy), and, in some cases, intraspinal decompression (via myelotomy). in addition, the investigators had developed a weight-bearing walking training program named "kunming locomotion training program (kltp)" to train the patient to walk actively for a duration of 6 hours per day, 6 days per week for a minimum of 6 months (6-6-6 kltp). the investigators reasoned that early surgical intradural and/or intraspinal decompression would release the intraspinal pressure and, therefore, spare surrounding tissues that would otherwise degenerate during the course of secondary injury. the investigators further reasoned that long-term weight-bearing walking training would "retrain" the residual spinal pathways facilitating recovery of locomotor function, and that a combination of the two would result in even greater functional recoveries.

Eligibility criteria:
inclusion criteria: * injury levels included cervical, thoracic and lumbar spinal levels; * neurological examination was ais-a; * diagnosis of sci was confirmed by mri. exclusion criteria: * penetrating injuries that caused complete transection of the spinal cord; * patients with severe brain injuries or other neurological disorders; * patients with lower motoneuron diseases; * patients with other conditions including pregnancy, and significant medical, infectious, and psychiatric conditions.

Keywords: surgical intervention decompression walking training functional recovery spinal cord injury