Kornimate/medical-research-clean huggingface dataset:
co-infections in children hospitalised for bronchiolitis

Conditions: Bronchiolitis

Summary: observational cohort study in children hospitalized for acute bronchiolitis. patients are nursed in cohort isolation. aim is to investigate the incidence and clinical impact of co-infections in this group.

observational cohort study in children hospitalized for acute bronchiolitis. patients are nursed in cohort isolation, meaning that all patients admitted for bronchiolitis are cohorted together, irrespective of viral diagnosis. aim is to investigate the incidence and clinical impact of co-infections in this group.

Eligibility criteria:
inclusion criteria: * younger than 2 years admitted for bronchiolitis exclusion criteria: * chronic lung disease congenital heart defect down syndrome
fsme immun new follow-up to study 208 in volunteers aged 16 to 66 years

Conditions: Encephalitis, Tick-borne

Summary: the aim of this study is to evaluate the safety of the third vaccination with fsme-immun new in all volunteers who received both vaccinations in baxter study 208 (safety study of fsme immun new and encepur in healthy volunteers aged 16 to 65 years).


Eligibility criteria:
inclusion criteria: * received two vaccinations during the course of baxter study 208 * understand the nature of the study, agree to its provisions and give written informed consent * for volunteers under 18 years of age - written informed consent of the parents/legal guardian is given exclusion criteria: * none. volunteers assessed for eligibility to receive a third vaccination. eligibility to receive third vaccination: * elisa value \> 126 vie u/ml before the first tbe vaccination in baxter study 208 * not clinically healthy, (i.e. the physician would have reservations vaccinating with fsme-immun new outside the scope of a clinical trial) * have already been administered a third tbe vaccination elsewhere since receiving the two vaccinations in baxter study 208 * have had an allergic reaction to one of the components of the vaccine since the last vaccination in baxter study 208 * suffer from a disease (e.g. autoimmune disease) or are undergoing a form of treatment (e.g. systemic corticosteroids, chemotherapeutics) that can be expected to influence immunological functions * have a known or suspected problem with drug or alcohol abuse (\> 4 liters wine / week or equivalent dose of other alcoholic beverages) * have received banked human blood or immunoglobulins within one month of study entry * are known to have become infected with hiv (a special hiv test is not required for the purpose of the study) since the last visit of study 208 * have had a vaccination against yellow fever and / or japanese b-encephalitis since the last visit in study 208 * have received an investigational new drug within 6 weeks prior to study start * have a positive pregnancy test at the first medical examination (for females capable of bearing children) * do not agree to employ adequate birth control measures for the duration of the study (for females capable of bearing children)

Keywords: tick-borne encephalitis
molecular mechanisms and diagnosis of mastocytosis

Conditions: Mastocytosis

Summary: mastocytosis is a disorder characterized by presence of excessive numbers of mast cells in skin, bone marrow and internal organs. it can affect both children and adults, males and females and individuals from all ethnic backgrounds, although precise demographic information about the affected populations is not available as it is a rare disorder. mastocytosis in children is generally limited to the skin and follows a self limited course, while it is a disorder of the hematopoietic stem cell associated with somatic mutations of the c-kit gene in most patients with adult-onset of disease. there is no known curative therapy for most patients with systemic mastocytosis. recent research studies identified several subtypes of disease with distinct clinical and pathologic features, however, a precise understanding of the incidence as well as molecular pathology of different disease subtypes is lacking. this study aims to examine molecular and cellular pathological aspects of disease in patients with mastocytosis and correlate findings with clinical presentation and prognosis. patients will undergo a routine history and physical examination, and diagnostic tests will be ordered as dictated by each patient's clinical presentation. blood and bone marrow will be obtained for diagnostic and research purposes. genetic analysis of the c-kit gene regulating mast cell growth and differentiation will be performed. it is hoped that findings obtained from this study will help to design novel therapies for mastocytosis and other disorders in which mast cells play a critical role.


Eligibility criteria:
inclusion criteria: * confirmed or suspected diagnosis of mastocytosis. * ability to give informed consent (by the patient or legal guardian if minor) exclusion criteria: * inability or not willing to provide informed consent.

Keywords: mast cell disease anaphylaxis c-kit mutation mastocytosis (suspected or proven)
mix vaccine for metastatic colorectal cancer

Conditions: Metastatic Colorectal Cancer; Reaction - Mixed Vaccine

Summary: the aim of this study is the safety and efficacy of mix vaccine to small metastases of colorectal cancer.

by enrolling patients with small metastases of colorectal cancer adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of mix vaccine. the safety will be evaluated by statistics of adverse reactions. the efficacy will be evaluated according to local relief degree, progress free survival (pfs) and overall survival (os).

Eligibility criteria:
inclusion criteria: * all standard therapies have failed according to nccn guidelines or the patient refuses standard therapies after cancer recurrence * body tumor 1-6, the maximum tumor length \< 2 cm * kps ≥ 70, lifespan \> 6 months * platelet count ≥ 80×109/l，white blood cell count ≥ 3×109/l, neutrophil count ≥ 2×109/l, hemoglobin ≥ 80 g/l exclusion criteria: * patients with cardiac pacemaker * patients with brain metastasis * patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction
effects of aerobic versus resistance training in post percutaneous coronary intervention obese patients

Conditions: Cardiovascular Diseases

Summary: the randomized clinical trial (rct) endeavors to enroll 50 participants, divided equally into aerobic exercise and resistance exercise groups. the study employs rigorous tools such as blood pressure measurement, sf-36 questionnaire, and the six-minute walk test (6mwt) to assess vo2max.

the randomized clinical trial (rct) endeavors to enroll 50 participants, divided equally into aerobic exercise and resistance exercise groups. the non-probability convenient sampling technique, followed by random allocation using a lottery method, ensures a diverse yet unbiased sample. will be conducted at the sialkot medical and physiotherapy centre, the inclusion criteria will focus on post-pci patients aged 40-60, presenting with a bmi of 30 or higher. the study employs rigorous tools such as blood pressure measurement, sf-36 questionnaire, and the six-minute walk test (6mwt) to assess vo2max. the aerobic exercise group undergoes sessions three times a week, progressively increasing in duration and intensity, emphasizing activities like brisk walking and cycling. the resistance exercise group follows a similar schedule, engaging in full-body resistance exercises targeting major muscle groups. both groups undergo assessments using cardiopulmonary exercise testing (cpet) to determine exercise tolerance accurately.

Eligibility criteria:
inclusion criteria: * age: participants must be between 40 and 60 years old. * gender: male and female both. * cardiovascular status: post percutaneous coronary intervention (pci) patients with a documented history of coronary artery disease * participants who are at least three months post pci to ensure stabilization of their cardiovascular condition. * obesity: participants must have a body mass index (bmi) equal to or greater than 30 kg/m², indicating obesity. * health status: participants should be in stable health condition to participate in moderate physical activities. * willingness to participate: participants must provide informed consent and be willing to comply with the study protocol, including attending scheduled exercise sessions and follow-up assessments. * participants capable of engaging in either aerobic or resistance training, were assessed by a physical activity readiness questionnaire (par-q). exclusion criteria: * participants with severe physical limitations, disabilities, or musculoskeletal disorders that would prevent them from engaging in aerobic and resistance exercises. * individuals with a history of substance abuse or current substance abuse issues that might interfere with their ability to participate or adhere to the study protocol. * patients with neurological diseases * patients with severe or unstable heart conditions, recent heart attack, or heart failure

Keywords: aerobic exercise angioplasty obese patients percutaneous coronary intervention resistance training
helping hand: healing anorexia nervosa digitally

Conditions: Anorexia Nervosa

Summary: the proposed project will develop and pilot a coached mobile app, including a social networking component, for individuals with anorexia nervosa to use in the post-acute period

anorexia nervosa (an) is a costly and life-threatening illness. patients with severe an are often treated in the acute setting, but relapse after treatment is common. further, the discharge criterion in acute settings is typically weight restoration. however, research has indicated that weight-based recovery is not "enough" and that full recovery involves physical, behavioral, and psychological components. cognitive-behavioral therapy (cbt) is useful with this population, including following discharge, and may aid in addressing psychological symptoms, achieving full recovery, and decreasing relapse. however, very few patients have access to providers trained in these techniques. mhealth technologies have great potential to exponentially increase access to high-quality services for the post-acute treatment of an by addressing barriers to treatment, but to date, research on these approaches has been extremely limited. a guided self-help cbt-based mobile app, studentbodies-eating disorders (sb-ed), has been successfully developed, demonstrating effectiveness among college women with binge/purge-type eds. at the same time, there is demonstrated support for in-person cbt for the post-acute care and relapse prevention of adult an. the overarching goal of this r34 is thus to develop and test a cbt-based, coached mobile app to address the post-acute care and relapse prevention.

Eligibility criteria:
inclusion criteria: * cisgender women who are 18 years old and older, who own a mobile phone, speak english, are u.s. residents, have a bmi greater than or equal to 17, who are connected with a physician (such as a primary care provider), who are not using a feeding tube, and who have been discharged from intensive treatment (i.e., inpatient, residential, partial hospitalization, intensive outpatient) for dsm-5 anorexia nervosa within the past 2 months. exclusion criteria: * individuals who are not cisgender women. * individuals under 18 years old. * individuals who do not own a mobile phone. * individuals who have not been discharged from intensive treatment (i.e., inpatient, residential, partial hospitalization, intensive outpatient) for dsm-5 anorexia nervosa within the past 2 months). * individuals who are not connected with a physician (such as a primary care provider) * individuals who have a bmi below 17.0 * individuals who are currently using a feeding tube
use of vibration during constraint-induced movement therapy

Conditions: Hemiparesis

Summary: the purpose of this study is to determine whether the hand function will improve more by using low-level vibration during constraint-induced movement therapy (cimt), compared to cimt alone without vibration.

the low-level vibration has been shown to increase therapy outcome when used as an adjunct to therapy in adults with hemiparesis. children who participates in the cimt camp at musc will be recruited to take part in the study. participating children will wear a watch device on their weaker arm during cimt. the watch will vibrate only for the children who were assigned to the treatment group.

Eligibility criteria:
inclusion criteria: * unilateral upper limb motor weakness * can use the affected upper limb as a gross assist during play and self-care activities * ambulatory for their age with intact balance and protective reactions in the less involved upper limb. exclusion criteria: * developmental delays limiting spontaneous use of the affected upper limb * other health impairment

Keywords: constraint-induced movement therapy
open-label safety study of solriamfetol in subjects with binge eating disorder

Conditions: Binge-Eating Disorder

Summary: this is a phase 3, multi-center, open-label study to evaluate the long-term safety and efficacy of solriamfetol in the treatment of binge eating disorder (bed) in adults.

eligible subjects will have previously completed the sol-bed-301 (engage) study. this study consists of a baseline visit, a 2-week titration phase, and a 50-week maintenance phase, followed by a 1-week follow-up period.

Eligibility criteria:
inclusion criteria: * completion of the treatment period in study sol-bed-301. * able to comply with study procedures. exclusion criteria: * significant change in vital signs, medical history or concomitant medications since enrolling in the sol-bed-301 study which, in the opinion of the investigator or the medical monitor, would render the subject unsuitable to receive solriamfetol or participate in the study.

Keywords: binge eating disorder bed solriamfetol sunosi axsome non-stimulant therapy dopamine norepinephrine reuptake inhibitor trace amine-associated receptor 1 (taar1) agonist
strengths and weaknesses of physiotherapy in the daily work of an intensive care unit

Conditions: Healthcare

Summary: background. a stay in the intensive care unit can cause long-term problems and physiological changes at the neuromuscular and respiratory levels in critically ill patients. early physiotherapy in these patients is safe and feasible to avoid or reduce the adverse musculoskeletal and respiratory effects of the stay in this hospital unit. objective. to identify the strengths and barriers of physiotherapy in an intensive care unit, according to the vision of different health science professionals. method. qualitative observational study using individual interviews and focus groups. 18 people (6 doctors, 6 nurses and 6 physiotherapists) will be included in the study. the 18 health professionals will participate in personal interviews and focus groups (3 focus groups with 6 participants each). participants will be recruited from the intensive care unit of the hospital universitario central de asturias. data will be analysed using the thematic analysis approach according to braun and clarke's method. we will use face-to-face interviews and focus groups to collect data and analyse them through thematic analysis. purposive sampling will be used to recruit our participants. we will continue to recruit participants, if necessary, until saturation of data from the thematic analysis is reached. expected outcomes. to assess the knowledge, perceptions and expectations of the healthcare staff in the intensive care unit regarding physiotherapy in the management of patients admitted to this unit. to identify the strengths of physiotherapy in the management of these patients.


Eligibility criteria:
inclusion criteria: * professionals from the intensive care unit of the hospital universitario central de asturias. * with clinical experience of at least 2 years. * currently working or having worked in coordination with physiotherapists in the intensive care unit. exclusion criteria: * professionals who are unfamiliar with the usual physiotherapy therapy in an intensive care unit. * resident interns in their first year of training.
dichloroacetate treatment of congenital lactic acidosis phase b: expanded access

Conditions: Mitochondrial Enzyme Deficiencies

Summary: expanded access to dca as continued treatment for congenital lactic acidosis.

subjects who participated in a phase 3 randomized controlled trial of dca for treatment of congenital lactic acidosis (cla) are eligible to continue treatment with investigational medication dca at the same dose of 25mg/kg/day for expanded access. study participants must travel to the study site for bi-annual evaluation by the study investigator. bi-annual evaluation will include an interim medical history review, physical exam, blood collection for dca trough level, and urine pregnancy testing (if indicated).

Eligibility criteria:
inclusion criteria: * diagnosis of congenital lactic acidosis * participation in study: #183-1992: dichloroacetate treatment of congenital lactic acidosis exclusion criteria: * intolerance to dca

Keywords: dichloroacetate (dca) congenital lactic acidosis (cla) acidosis orphan disease
validity and reliability of ctq-sss in carpal tunnel syndrome.

Conditions: Carpal Tunnel Syndrome

Summary: to determine the validity and reliability of the shorter version of the ctq-sss in patients with carpal tunnel syndrome (cts) undergoing nonsurgical management.


Eligibility criteria:
inclusion criteria: * patients diagnosed with carpal tunnel syndrome based on clinical presentation and/or nerve conduction studies. * patients aged 18 years to 60 years old. * patients who are undergoing nonsurgical management for carpal tunnel syndrome. exclusion criteria: * patients with a history of hand or wrist surgery within the past 6 months. * patients with severe hand or wrist pain that would prevent completion of the outcome measures or interfere with their ability to participate in the study. * patients with severe cognitive impairment or language barrier that would prevent understanding of the study instructions or interfere with their ability to participate in the study. * patients with any other medical condition that could affect hand function or interfere with test completion.
marfan syndrome (mfs) and facial dysmorphism: non-invasive 3d assessment

Conditions: Rare Diseases; Marfan Syndrome

Summary: the goal of this study observational prospective study is to define the facial morphological features associated with marfan syndrome (mfs). the main qustion it aims to answer are: 1. to describe the facial morphological features associated with mfs and their evolution over time; 2. to study the association between facial morphology and the features of reference for the diagnosis of mfs.

marfan syndrome (mfs, omim # 154700) is a rare connective tissue disorder caused by mutations in the gene encoding fibrillin-1 glycoprotein (fbn1), involved in the development of microfibrils. since fbn1 is a constituent of the connective tissue present at a systemic level, mutations in its gene lead to alterations of the connective tissue, even with pleiotropic effects. the clinical manifestations of mfs are heterogeneous and can occur at any time, from neonatal onset to infancy or adolescence. in this sense, the presence of facial dysmorphism could help in early diagnosis of the disease. considering the craniofacial features, the phenotypic manifestation related to the syndrome mfs are: dolichocephaly, eyelid down-slanting, malar hypoplasia and retrognathia. however, few studies have so far studied the facial features associated with mfs. morevoer, there is a gap in the literature for the evaluation of the progression of facial morphology in the pediatric mfs population as well as potential correlations between facial dysmorphism and other manifestations of the disease.

Eligibility criteria:
inclusion criteria: * white european ethnicity; * signed informed consent; exclusion criteria: * previous relevant traumas affecting the craniofacial district or maxillofacial surgery; * presence of beard and mustache; * pregnancy

Keywords: rare diseases marfan syndrome facial features
prevalence of sarcopenia and its geriatric features

Conditions: Sarcopenia

Summary: the goal of this study is to determine the prevalence of sarcopenia in a geriatric hospital ward. sarcopenia is defined by a loss of muscle mass, loss of muscle strength and loss of muscle quality. it is a geriatric syndrome that, to this date, is not systematically tracked in clinical practice. in order to detect sarcopenia, the investigators will use the operational definition proposed by the european working group (ewgsop) involving the measure of three parameters, namely the speed of walking, the muscle strength and the measurement of the muscular mass.


Eligibility criteria:
inclusion criteria: * to be admitted in the unit 83 of the geriatric departement of the chu brugmann hospital, from 10/01/2016 till 30/03/2017. exclusion criteria: * patients unable to consent or without representatives * patients unable to perform the hand- grip test, the walk test or measurement of the body components by dexa * patients in severe pain * bedridden patients * patients for which a clear therapeutic abstention has been established * language barriere that cannot be overcome * patients unable to walk without the help of a third person

Keywords: sarcopenia geriatry
mirror therapy and cross-education of muscle strength

Conditions: Cerebrovascular Stroke; Muscle Weakness

Summary: this study was conducted to determine whether mirror therapy has an additive effect on cross-education of the strength of neuromuscular electrical stimulation (nmes) in patients with hemiplegia. as an outcome measure, the ankle dorsiflexion strength of hemiplegic patients was measured.

a total of 29 patients, 7 women, and 22 men were included according to the inclusion and exclusion criteria. the patients were randomly assigned to the control group (n = 14) and the mirror group (n = 15). five sessions of neuromuscular electrical stimulation, unaffected side ankle dorsiflexors were applied to the patients in both groups. in addition to the nmes, mirror therapy was applied to the experimental group simultaneously with nmes. before and after treatment, both ankle dorsiflexor strength was measured with a force sensor. for force measurements, a force transducer (fc2211-0000-0100-l compression load cell, te connectivity company, france) was used. force transducer signals were received with a data acquisition device (powerlab® data acquisition system adinstruments, oxford, uk) and evaluated offline on the computer. the measurement values were expressed in kilogram.force (kg.f) and this value was normalized according to body weight.

Eligibility criteria:
inclusion criteria: * cases with stroke duration ≥ 1 month * ability to walk at least 10m (functional ambulation scale ≥3) * age range 18-75 years * hemorrhagic or ischemic stroke * brunnstrom stage ≥4 for lower limb * unilateral stroke * cooperating with the examination and tests exclusion criteria: * mini mental state assessment score \<21 * severe spasticity (mas = 4) in ankle dorsiflexors * have a contracture on ankle joint * the presence of skin lesions in the application area * painful pathologies in the lower extremities * having visual field defects * active inflammatory, rheumatological or infectious disease * parent rhythm / conduction block problem in the heart * uncontrollable hypertension (maxima\> 140, minima\> 90) * presence of lower extremity fracture * peripheral nerve lesions such as polyneuropathy, radiculopathy * finding or suspected active deep vein thrombosis * history of deep vein thrombosis and pulmonary embolism

Keywords: cross-education neuromuscular electrical stimulation mirror therapy