Kornimate/medical-research-clean huggingface dataset:
comparing the gastric emptying times of underweight and healthy-weight school-aged children

Conditions: Preoperative Fasting

Summary: in the recent literature, preoperative fasting times for pediatric patients are limited to one hour for clear fluids. studies related to gastric emptying times mostly searched for normal-weight children. these studies have claimed that 3 ml/kg of clear liquid can be allowed up to 1 hour before surgery. there is a lack of interest in the gastric emptying time of underweight pediatric patients during the preoperative period. recent studies suggest that underweight children may experience rapid gastric emptying. this trial compares the gastric volume and emptying time after ingesting 3 ml/kg clear fluid in underweight and normal-weight pediatric patients in the preoperative period.

after receiving informed consent from the children and their families, the american society of anesthesiologists (asa) 1-2 pediatric patients between 6 and 14 years who will be recruited for elective surgery will be included in this study. the children under the 5% percentile will be accepted as underweight. after, the basal gastric volume will be calculated with the help of ultrasonography (usg). the children will receive oral 3 ml/kg 5% dextrose. usg evaluation will be made every 5 minutes until the gastric volume reaches the basal level. children reaching basal gastric volume will be accepted as suitable for the surgery. this study compares the gastric volume and emptying time after ingesting 3 ml/kg clear fluid in underweight and average-weight pediatric patients in the pre-operative period.

Eligibility criteria:
inclusion criteria: * asa physical state i or ii * age 6 to 14 years. * gender: both sexes. * scheduled for non-gastrointestinal tract elective day-case surgery under general anesthesia. exclusion criteria: * parent/caregiver refusal * ages \ 14 years old * children with gastroesophageal reflux disease * renal failure * diabetes mellitus * cerebral palsy patients * mental retardation * esophageal strictures, achalasia, or any intestinal disease that may impair gastric emptying. * gastrointestinal system surgery and neurosurgical patients * emergency surgery * violation of the prescribed fasting times * refusing to drink prescribed clear fluid

Keywords: gastric empyting gastric volume ultrasonography
oxidative stress in stargardt disease, age related macular degeneration and diabetic retinopathy

Conditions: Stargardt Disease; Diabetic Retinopathy; Macular Degeneration (Age Related)

Summary: in this study, markers of oxidative stress will be measured in the aqueous humour of stargardt disease, age related macular degeneration and diabetic retinopathy patients compared to controls.

people with stargardt disease, age related macular degeneration (amd) and diabetic retinopathy (dr) have decrease in central vision from damage to photoreceptors. one of the mechanisms causing damage is high levels of oxygen in the eye. this damage produces specific biomarkers that can be measured in eye fluid (aqueous humor). in this study, these biomarkers will be assessed in people with stargardt disease, age related macular degeneration and diabetic retinopathy, compared to controls.

Eligibility criteria:
inclusion criteria: * signed informed consent and authorization of use and disclosure of protected health information * age at least 18 years * for the study group, patients diagnosed with stargardt disease, age related macular degeneration and diabetic retinopathy by the investigators, based on clinical phenotype * for the control group, patients with no retinal disease undergoing cataract surgery will be eligible. exclusion criteria: • none

Keywords: dr amd
the effects of kefir on pediatric obesity

Conditions: Obesity

Summary: kefir, a traditional fermented dairy product in the north caucasus region, is produced through the fermentation of milk by lactic acid bacteria and yeast. in murine studies, it has been observed that consumption of kefir by obese mice resulted in significantly reduced body weight compared to non-kefir-consuming obese mice. furthermore, insulin resistance and fatty liver conditions showed improvement in the kefir-fed obese mice. kefir was found to have its effects on obesity-related conditions through the inhibition of lipid synthesis, stimulation of fatty acid oxidation, elevation of basal metabolic rate, and modulation of oxidative damage. obesity has emerged as a global epidemic, and its prevalence in pediatric population is rapidly increasing. obesity is defined as having a body mass index (bmi) above the 95th percentile for the age. according to statistics from the health promotion administration in taiwan, the prevalence of obesity among elementary and junior high school students in 2021 was 27.1% and 31.2%, respectively. this implies that approximately one out of every three to four students is obese. insulin resistance and fatty liver are two common manifestations of childhood obesity. insulin resistance is found closely linked to type 2 diabetes. prolonged and chronic fatty liver can progress to cirrhosis and even hepatocellular carcinoma. effective management of obesity holds the occurrence of these diseases. the objective of this study is to analyze the potential benefits of incorporating kefir into the diet of obese children regarding the improvement of obesity-related outcomes.


Eligibility criteria:
inclusion criteria: * body weight above 50 kilograms, body mass index (bmi)-for-age above the 95th percentile exclusion criteria: * diabetes mellitus, liver diseases other than non-alcoholic fatty liver disease, cardiovascular diseases other than hypertension and dyslipidemia, renal diseases, neurologic diseases, growth hormone deficiency, thyroid diseases, adrenal disorders, any use of medication for more than 6 months before or during this study, and any adverse responses to dairy products.
remote monitoring in patients with heart failure

Conditions: Heart Failure

Summary: this study is a prospective cohort study with consecutive enrollment of newly diagnosed heart failure patients, investigating the prevalence and types of arrhythmias in this high-risk population using non-invasive remote monitoring with the coala heart monitor. participants are scheduled to use the coala heart monitor twice daily or during symptoms (e.g. syncope, presyncope, palpitations, chest discomfort, or shortness of breath) to record a thumb and chest ecg over 3 months. patient compliance with the recordings, self-reported health, response to technology, and experience using the device will additionally be assessed by self-developed questionnaires and the kansas city cardiomyopathy questionnaire (kccq) at 3 months.


Eligibility criteria:
inclusion criteria: * owns or has access to a smartphone * newly diagnosed moderate to severe heart failure (nyha ii-iv and left ventricular ejection fraction ≤ 40%) exclusion criteria: * earlier atrial fibrillation/atrial flutter with indication for oral anticoagulant (oac) treatment * pacemaker * cardiac resynchronization device * indications for oac treatment (also low molecular weight heparin) due to atrial arrhythmias, mechanical heart valve, deep vein thrombosis, or pulmonary embolism. * expected survival ≤ 6 months * absolute contraindications for starting oac treatment

Keywords: arrhythmias heart failure remote monitoring
epilepsy-associated stigma

Conditions: Epilepsy

Summary: few data about epilepsy-associated stigma in france are available. the only study we have found showed that in france 66% of people with epilepsy felt stigmatized by their condition and are often single, compared with the other european patients interviewed (baker et al., 2000). the purpose of this study is to assess the association between type of epilepsy (drug resistant-epilepsy and stabilized epilepsy) and perceived stigma (using the stigma scale) in patients recruited in the limousin region .

epilepsy-associated stigma leads important problems in terms of public health because it can provoke significant cognitive repercussions, impairment of quality of life and it causes physical injuries and serious disabilities. these social consequences often cause more suffering for patients than seizures themselves. this heavy medical and social burden is associated with significant economic cost in terms of care and disability. it is also noted that mortality rate is 2 to 10 times higher than the general population. it is therefore urgent to consider both medical and social dimension of consequences of epilepsy especially in patients with uncontrolled seizures. it is also essential to detect a potential psychiatric disorder associated with epilepsy, especially depression and anxiety which are the most prevalent psychiatric comorbidities. these disorders are often under-diagnosed that can frequently leads to an inappropriate care. the purpose of this study is to assess the association between type of epilepsy (drug resistant-epilepsy and stabilized epilepsy) and perceived stigma (using the stigma scale) in patients recruited in the limousin region . the primary outcome will be the score of perceived stigma obtained from the stigma scale. this scale estimates a score of perceived stigma for each individual and allows classifying individuals in 3 categories. thus, individuals who obtain a total score of 0 will be those who do not feel stigmatized. those whose scores will be over or equal to 1will be those who feel stigmatized. finally, respondents whose the score is equal to 3 will be considered as having a strong perception of stigma. a positive response is characterized by threshold ≥ 1.

Eligibility criteria:
inclusion criteria: * 18 years and above * diagnosed by a neurologist as suffering from drug-resistant epilepsy (all types of seizures) outpatient in neurology service of the investigation centres * inhabitant in the limousin region * having signed the informed consent * affiliated or profiting of a social security system exclusion criteria: * patients that are deprived of their freedom * patients with disabilities * patients suffering from a chronic or an acute delusional disorder * patients suffering from others handicaps

Keywords: epilepsy stigma
cardiac arrhythmia in patients with end-stage renal disease

Conditions: End Stage Renal Disease on Dialysis; Cardiac Arrhythmia; Diabetes Mellitus; Hypoglycemia

Summary: the study will examine the presence of cardiac arrhythmias in patients receiving hemodialysis and the role of diabetes, hypoglycemia and parameters related to uremia and the dialysis procedure. the study is designed as a prospective cohort study with 18 months follow-up. 70 patients receiving chronic hemodialysis will be recruited and equipped with implantable loop recorders (ilr): 35 patients with diabetes and 35 patients without diabetes. data collection during the follow-up includes continuous monitoring of the heart rhythm by the ilr for the entire follow-up period, continuous glucose monitoring for 10 days every second month, and monthly collection of blood samples and dialytic parameters. after the initial 18-month follow-up, heart rhythm monitoring will continue until the ilr battery runs out for those participants who wish to continue.


Eligibility criteria:
inclusion criteria: patients with diabetes: * type 1 diabetes or type 2 diabetes diagnosed according to the criteria of the world health organization * treated with glucose-lowering drugs at inclusion * receiving in-center maintenance hemodialysis for more than 3 months * age ≥ 18 years patients without diabetes: * no known diagnosis of diabetes * no previous treatment with glucose-lowering drugs * hba1c \< 48 mmol/mol at screening * receiving in-center maintenance hemodialysis for more than 3 months * age ≥ 18 years exclusion criteria: for both groups: * cardiac pacemaker or implantable cardioverter defibrillator (icd) * known permanent (chronic) atrial fibrillation * history of sustained (\> 30 seconds) ventricular tachycardia (more than 200 bpm) or ventricular fibrillation (note that ventricular premature beats is not considered an exclusion criterion) * known cardiac ion-channel disease (such as long qt syndrome and brugada syndrome) * not suitable for implantation (left-sided dialysis catheter or other condition expected to interfere with implantation) * previously complications in relation to wearing a cgm sensor, e.g. allergic reaction * inability to give written informed consent
comparison of keloid volume and symptoms reduction between intralesional umbilical-cord mesenchymal stem cells, its conditioned medium, and triamcinolone acetonide injection as keloid therapy: a randomised controlled trial

Conditions: Keloid; Stem Cell

Summary: this study is a double-blind randomized controlled trial (rct) examining the effect of intralesional injection of umbilical cord-derived mesenchymal stem cells (uc-msc), umbilical cord-derived conditioned medium (uc-cm), or triamcinolone acetonide (ta) on keloids carried out using consort statement. research is directed at studying keloid volume reduction and changes in posas score.

patients were screened initially by measuring the length and thickness of the keloids using a ruler. patients who met the study inclusion criteria were randomly divided into three groups. each patient in the groups was given the same injection volume (1 ml) in every cm3 keloid volume using a 1 ml syringe and 27g needle. the injections were ultrasound-guided into the center of the lesion with a 30-45-degree angle using an in-plane technique, therefore the same pressure. group 1 was given umbilical cord-derived mesenchymal stem cells (uc-msc) 2 million cells/ml/cm3, group 2 was given umbilical cord-derived conditioned medium(uc-cm) 1 ml/cm3, and group 3 was given triamcinolone acetonide (ta) 40 mg/ml/cm3. all patients received a single dose and 1 booster dose. the percentage of keloid volume regression in each treatment group was calculated by calculating the difference in volume before and after therapy with a 3-dimensional ct-scan, then expressed as a percentage. the ct-scan volume was obtained with the smartvitrea application (figure 2), then a posas examination will be carried out for subjective and objective assessment.

Eligibility criteria:
inclusion criteria: * the patient has keloids with a length of 2-10 cm and a thickness of 3-5 mm located on the chest, back, abdomen and extremities * patients aged 18 - 55 years * post-surgery patients more than 3 months that cause keloids * the patient is willing to fill in the informed consent form exclusion criteria: * patients with hypertrophic scars * history of kidney failure * hypertension * pregnant and breastfeeding * history of blood disorders * history of tumor or malignancy * get other keloid therapy outside of the research procedure

Keywords: keloid therapy mesenchymal stem cells keloid volume posas
outcome of a triple inner branched aortic arch stentgraft. a prospective, multicenter registry.

Conditions: Aortic Arch; Aortic Arch Aneurysm; Dissection of Aortic Arch; Triple Branch

Summary: outcome of a triple inner branched aortic arch stentgraft. a prospective, mulitcenter registry.


Eligibility criteria:
inclusion criteria: * 18 years or older * presence of aortic arch pathology * treatment planned with triple inner branch from terumo aortic * availability of the patients during the follow up period * informing patients about the study and providing written informed consent exclusion criteria: * women of childbearing age * patients under 18 years

Keywords: aortic arch pathologies aortic arch aneruysm aortic arch dissection triple branch stentgraft double branch inner branch
pins stimulator system to treat severe anorexia nervosa

Conditions: Anorexia Nervosa

Summary: anorexia nervosa (an) has the highest mortality of any psychiatric disorder and a paucity of effective treatments. an becomes intractable in around 20%, resulting in huge individual and healthcare costs. the study will help patients with severe an using dbs. individuals with severe intractable an will be eligible to take part in the study.


Eligibility criteria:
inclusion criteria: 1. female or male patients aged 20-60 years. 2. diagnosis of anorexia nervosa, restricting or binge-purging subtype, as defi ned in the diagnostic and statistical manual of mental disorders (dsm-iv-tr). 3. chronicity or treatment resistance shown by some or all of: * a pattern of 3 years' duration of relentless unresponsiveness to repeated voluntary hospital admissions, characterised by failure to complete treatment or immediate weight relapse after treatment. * a pattern of increasing medical instability, accompanied by refusal to participate in or a pattern of poor response to intensive expert treatment and increasing medical acuity, lasting at least 2 years and including at least two episodes of involuntary feeding. * a pattern of chronic stable anorexia nervosa that has lasted at least 10 years. * able to provide informed consent. 4. able to comply with all testing, follow-ups, and study appointments and protocols. exclusion criteria: 1. person with consciousness disorder on opioid abstinence, seriously aggressive, heavily dehydrated and intending to commit suicide. 2. patients with serious liver and kidney dysfunction, pulmonary decompensation, or complicated with serious damage in other systems. 3. patients with serious infectious disease. 4. patients with history of serious neurological or psychiatrical diseases. 5. person with history of hiv infection or serious malnutrition. 6. dependent upon and addicted to multiple drugs. 7. any contraindication to mri or pet scanning. 8. body-mass index less than 13. 9. attended some other trials within one year.
the inclined position in case of respiratory discomfort in the one year less infant : study on the profits and the risks in the home

Conditions: Obstruction, Airway; Sudden; Death, Infant

Summary: the inclined position at 30 ° in case of transient respiratory discomfort is recommended since the consensus conference of september 2000. this recommendation is based on a low level of evidence (grade c). this advice is found in the health book, and in many tips for parents. however, it does not comply with the recommendations of the american academy of pediatrics for sleeping on the back, on a firm mattress and without other objects in the bed. 70% of pediatricians advise this position in a specific medical context according to a study of bellaïche conducted in 2013. 40% of parents use it for no particular reason. anatomically, the upper airways of infants are of reduced caliber, and therefore at risk of obstruction. a study by bergougnioux on the cases of min in infants wearing a wrap-around sling shows that the flexion of the neck causes the chin to be positioned against the chest and contributes to the suffocation of the infant. this is especially important in infants under 3 months whose neck muscles do not yet support the weight of the head. the 2009 invs national survey of unexpected infant deaths shows that bed crashes accounted for 11.1% of all deaths reported. among unexplained deaths, maladaptive bedding was a contributing factor, including the use of a pillow in the bed in 24.3% of cases. it was observed in the study by kornhauser cerar et al in 2009 that half-sitting in a car seat for an extended duration was at the origin of a significant desaturations rate, which was also found in the car bed group. the control group "hospital bed" was not subject to these desaturations. these results support the fact that only an adapted bedding that complies with the recommendations protects against asphyxiation. since 2016, inpes recommends in its advice sheet on bronchiolitis for parents, a flat bed on the back. hypothesis : the inclined position in infants under one year of age is at risk of unexpected death of the infant by obstruction of the upper airways, because of the changes of position that it entails, including a risk of slipping at the bottom of the bed and of asphyxiation under the covers.


Eligibility criteria:
inclusion criteria: * infant from 0 to 12 months * lie in a proclive position while sleeping * whose parents / parent authority holders informed about the terms of the study and agree to answer the questionnaire exclusion criteria: * refusal to participate
cerebral circulation in critically ill children

Conditions: Arterial Hypotension; Shock; Cerebral Lesion

Summary: the principal purpose of this study is to describe the changes in cerebral circulation (assessed by transcranial ultrasound) and oxygenation (assessed by near infrared spectroscopy, nirs) during resuscitation for hemodynamic failure (arterial hypotension or shock) in critically ill children treated with vasoactive or inotropic drugs. the secondary objectives are : i) to evaluate the association between an alteration of cerebral circulation and/or oxygenation and an alteration in macro-circulatory parameters (mean arterial blood pressure and cardiac output) or a bad outcome, ii) to study if cerebral autoregulation is impaired

pediatric shock is a frequent and serious cause of hospitalization in pediatric intensive care unit that can lead to multi-organ failure and death. its early recognition improves patients' outcome, as well as the establishment of targeted guidelines pursuing normalization of macro-circulatory parameters (ie blood pressure and lactate). however, regional hypoperfusion leading to organ failure can be present before the alteration of these parameters, and persist after their restoration. brain lesions are common in critically ill children with cerebral hypoperfusion, since they may have impaired autoregulation and permeable blood-brain barrier. vasoactive and inotropic drugs used for hemodynamic resuscitation should restore systemic and regional circulation, but may be inadequate on brain perfusion because of i) their variable and unpredictable cardiovascular effects , and ii) a strong interindividual variability between patients. as such, the impact of this medication on cerebral circulation and oxygenation is unknown. monitoring cerebral circulation and oxygenation during a hemodynamic resuscitation using catecholamines is a first step to identify risk factors of an altered brain perfusion, and to improve treatment of shock.

Eligibility criteria:
inclusion criteria: neonates and children from 0 to 18 years old hospitalized in pediatric intensive care unit (picu) with hemodynamic failure requiring vasoactive or inotropic treatment. this includes : * shock (tachycardia, troubles of peripheral perfusion with capillary refill time \>3 sec, oliguria, with or without alteration of consciousness or arterial hypotension) * isolated arterial hypotension if it needs medical treatment to readjust balance between oxygen demand and oxygen consumption exclusion criteria: * primitive cerebral lesion: traumatic or neurosurgical (including brain death states) * preterm neonates of less than 37 weeks gestational age * patients already receiving more than one catecholamine * patients too instable, defined by a respiratory instability (pulse oxymetry of less than 80% during more than 5 minutes) and/or hemodynamic instability (variability of blood pressure and heart rate of more than 50%) and/or cardiorespiratory arrest.

Keywords: near infrared spectroscopy brain perfusion pediatric shock catecholamines