Kornimate/medical-research-clean huggingface dataset:
genetics and fat taste sensitivity

Conditions: Obesity; Taste Sensitivity

Summary: a cross-sectional quantitative study will be carried out; recruiting female, caucasian participants aged 18-65 years. the relevance of candidate gene studies is disputed. research has shown associations between genotype and total fat intake. however, food preference is often described as a result of exposure to food types during upbringing. many single nucleotide polymorphisms (snp) have been associated with fat taste sensitivity, the majority of research shows that with a reduced sensitivity comes a higher total fat consumption. this study aims to assess the relationship between rs1761667 genotype, body mass index, fat intake, fat taste sensitivity and fat taste preference.


Eligibility criteria:
inclusion criteria: * european citizen. * caucasian * aged between 18-65 years. * female exclusion criteria: * currently following a diet or weight loss plan or have not been for over 6 months of the previous year. * suffering from diabetes (type i or ii). * have cancer, or have not had cancer in the past. * smoker. * pregnant. * lactose intolerant .
real-world analysis of belantamab mafodotin care patterns in patients with relapsed and/or refractory multiple myeloma

Conditions: Multiple Myeloma

Summary: the purpose of this study is to describe the real-world use of belantamab mafodotin - blmf (blenrep) and associated patterns of care, including dosing and dose modification, eye care specialist visits, associated healthcare utilization, and clinical outcomes in patients with relapsed and/or refractory multiple myeloma (rrmm) seen in the duke cancer institute (dci) clinics.


Eligibility criteria:
inclusion criteria: * age \> 18 years of age as of start of treatment with blenrep * patients with a corresponding diagnosis code consistent with multiple myeloma seen at duke. * patients with a record of starting treatment with blenrep for rrmm between august 5, 2020 and november 22, 2022. * patients having healthcare encounters at duke cancer institute (dci) for at least 1-month after start of blenrep treatment. exclusion criteria: * patients who were included in any clinical trial for blenrep including expanded access clinical trials * age \> 89 years of age as of start of index therapy

Keywords: relapsed refractory ophthalmology keratopathy distress national comprehensive cancer network (nccn) distress thermometer retrospective patient reported outcomes belantamab mafodotin blenrep
bilateral single-electrode vo combined with stn-dbs for treating meige syndrome

Conditions: Meige Syndrome

Summary: meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies. deep brain stimulation (dbs), initially developed to treat essential tremor and parkinson's disease, has been explored in recent years as a potential treatment for various dystonias, including meige's syndrome. this clinical study aims to evaluate the safety and efficacy of bilateral single-electrode ventralis oralis (vo) nucleus stimulation combined with subthalamic nucleus deep brain stimulation (stn-dbs) in patients with meige syndrome.

while deep brain stimulation (dbs) targeting the subthalamic nucleus (stn) or the globus pallidus interna (gpi) has shown moderate efficacy, incomplete symptom relief and high stimulation thresholds with associated side effects remain significant limitations. emerging evidence suggests that dual-target neuromodulation combining stn with ventralis oralis (vo) nucleus stimulation may synergistically modulate hyperactive basal ganglia-thalamocortical circuits, potentially enhancing therapeutic outcomes.the study will involve patients diagnosed with meige syndrome who are eligible for dbs therapy. participants will be randomly assigned to one of two groups.the primary outcome measure is the improvement in motor symptoms, assessed using the burke-fahn-marsden dystonia rating scale (bfmdrs) before and after treatment. secondary outcomes will include changes in quality of life, anxiety and depression scores, and any adverse effects related to the dbs procedure.the results of this study will be used to guide future clinical trials and inform the treatment options for patients with meige syndrome.

Eligibility criteria:
inclusion criteria: * must meet the clinical diagnostic criteria for meige syndrome * only includes patients with: blepharospasm-type meige syndrome and blepharospasm with lower jaw muscle dystonia-type * all patients must have undergone at least one year of systematic and standard treatment prior to surgery exclusion criteria: * history of neurological diseases other than meige syndrome * severe cognitive impairment * severe psychiatric disorders

Keywords: dbs
cognitive, emotional and behavioural impairments in patients after sars-cov2 infection

Conditions: COVID-19; Sars-CoV-2 Infection

Summary: recent studies suggest cognitive, emotional and behavioural impairments occur in patients after sars-cov-2 infection. problems with memory, attention, information processing and executive functions are particularly prevalent in these patients, probably due to hypothesised sensitivity of the hippocampus to the virus. cognitive impairment is also present in patients with no neurological, neuropsychological and neuropsychiatric history. therefore, the aim of the present study is to describe neuropsychological and neuropsychiatric features in patients recovered from moderate to severe forms of covid-19 some weeks after hospital dismission.


Eligibility criteria:
inclusion criteria: * positive pcr from nasopharyngeal swab * no icu admission exclusion criteria: * diagnosis of neurologic or psychiatric disorders; * previous cognitive impairment; * other medical conditions negatively affecting the cognitive status.

Keywords: covid-19 cognition teleneuropsychology memory executive functions
follicular fluid, bioavailable vitamin d and embryo quality markers

Conditions: Vitamin D Deficiency

Summary: to determine the correlation between bioavailable vitamin d values and euploid status of the embryos in larger size follicles from uae women undergoing in vitro fertilization procedures.

to study the possible correlation between bioavailable vitamin d values in follicular fluid and embryo quality markers. to correlate bioavailable vitamin d values in follicular fluid from large size follicles with embryo euploid status as our main objective. secondly, looking at morphokinetics and mitochondrial content of these embryos. taking into account that most of uae patients have deficiency or insufficiency of vitamin d, if there is a correlation found we will understand better the underlying mechanism by which bioavailable vitamin d levels may be affecting embryo quality, therefore ivf outcomes.

Eligibility criteria:
inclusion criteria: * women´s age \>18 - ≤43 years. * bmi 19-33 * male partner will produce fresh sperm sample on the same day of the egg collection procedure. * women with more than 10 follicles at the time of the trigger * at the time of egg retrieval, at least three follicles between 14-\<17 mm and three follicles ≥17 mm. * women ≤35 years old stimulation with rfsh antagonist * women ≥36 years old stimulation with highly-purified human menopausal gonadotropins (hphmg) specifically for the additional lh. * middle east population exclusion criteria: * polycystic ovarian syndrome (according to the rotterdam criteria). * patients at risk of ohss, according to the criteria previously described by papanikolau et al. (23). * history of endometriosis, classified according to the american fertility society (afs) as stage 3 or more. * severe male factor definition (\<2 million of sperm per ml of ejaculate) * recurrent miscarriage (3 miscarriages) * smokers * history of chemotherapy or radiotherapy
"pseudo-scanner" mri sequences for the detection of bone lesions in multiple myeloma

Conditions: Multiple Myeloma Bone Disease

Summary: recent work has confirmed the diagnostic performance of pseudo-ct sequences for detecting osteolytic lesions. their integration into whole body mri (wb mri) could transform the diagnostic approach to mm, by allowing a combined assessment of bone marrow involvement, tissue viability and osteolysis, during a single non-irradiating imaging examination. since the preliminary work mentioned above, optimizations have been made to the pseudo-ct sequences, including the addition of deep learning (correcting noise in the images) and the correction of chemical shift artifact (linked to the coexistence of hydrated tissue and fatty tissue), which carry real hope of improving their diagnostic potential and accuracy.

currently recommended imaging techniques for detecting bone lesions include whole-body mri (wb-mri), computed tomography (ct), and pet-ct. wb-mri and pet-ct outperform ct for assessing treatment response, with wb-mri already being the imaging modality of choice in many countries. however wb-mri, the technique of choice for detecting bone marrow involvement, does not allow visualization of mineral bone, limiting its ability to accurately assess osteolysis. zero echo time (zte) and lava flex low flip angle (lf) mri sequences represent a major advance, providing visualization of tissues at very short t2 relaxation times with resolution close to that of ct. these new sequences (known as pseudo-ct or pseudo-ct) offer for the first time the opportunity to study mineral bone by mri, thus considerably increasing the diagnostic potential of this modality in mm.

Eligibility criteria:
inclusion criteria: patient with newly diagnosed multiple myeloma, for whom bone imaging is required for staging. * recurrent patient after intensive treatment (high dose chemotherapy, bone marrow transplant, etc.). * patient requiring a pet / ct considered as the technique of choice in these stages of the disease. exclusion criteria: * implanted material incompatible with mri. * severe claustrophobia. * pregnant women

Keywords: bone imaging mri multiple myeloma
clinical efficacy of qingxin zishen decoction in treating menopausal syndrome and neuroendocrine mechanism of regulating kndy neurons

Conditions: Menopause

Summary: the goal of this clinical trial is to determine the effects of estrogen (fenmotong) and qingxin zishen decoction on the levels of kisspeptin, nkb, and dynorphin expressed in human kndy neurons between patients with menopausal syndrome. the aims of the study are as follows: * find a new neuroendocrine mechanism of qingxin zishen decoction in the treatment of menopausal syndrome. * evaluate the changes of new neuroendocrine indicators in the clinical treatment of menopausal syndrome. * develop non-hormonal drugs with definite efficacy in the treatment of menopausal syndrome. participants will randomly divided into the experimental group and the control group, the experimental group will be oral fenmotong, and the control group will be oral qingxin zi kidney decoction, and the efficacy, sex hormone levels and neuroendocrine index changes of the two groups will be compared.


Eligibility criteria:
inclusion criteria: * women aged 41\~55; * kim score≥ 15 points; * the number of hot flashes and sweating≥ 3 times/day; * menopause time≥ 6 months; * fsh\>30miu/ml,e2\<30ng/l; * informed consent, voluntary testing. exclusion criteria: * unexplained vaginal bleeding; * sex hormone-related malignant tumors cannot be excluded; * premature ovarian failure, or endometriosis, or hysterectomy, or bilateral adnexectomy; * combined with primary liver and kidney dysfunction, cardiovascular and cerebrovascular diseases, blood system diseases and other serious diseases that affect their survival; * exposure to sex hormone-related drugs within 3 months; * patients with mental abnormalities, or those with a history of alcohol or drug abuse; * those who have allergic reactions to the study drug; * those who are participating in other drug clinical researchers.
online-supervised exercise program in elderly people with diabetes

Conditions: Exercise Program; Type2diabetes

Summary: this study was conducted to determine the effect of an online-supervised exercise program on fasting blood sugar, psychological resilience, and quality of life in elderly people with diabetes. a parallel-group, randomized controlled trial design was used. the study was conducted in a public hospital with 70 patients with elderly type 2 diabetes between nowember 2021 and may 2022. a personal information form, the brief resilience scale and a measure of quality of life in the elderly were used to collect data.


Eligibility criteria:
inclusion criteria: * having a diagnosis of type 2 diabetes mellitus for at least 6 months, * being aged \>50 years, * receiving oral antidiabetic and/or insulin therapy, * having a smartphone or a computer, * volunteering to participate in the study, exclusion criteria: * individuals who had type 2 dm, but were illiterate * had vision and hearing loss * did not volunteer to participate in the study

Keywords: psychological resilience quality of life distance education
a comparison of paediatric weight estimation methods for emergency resuscitation

Conditions: Body Weight

Summary: the purpose of this study is to study the validity, reliability and practicality of the different weight estimation methods (parent estimation method, mercy method, broselow tape, original and update apls) in thai children.

a reliable paediatric weight estimation method is crucial for the physician attempting to resuscitate an injured child. when a patient is in a critical, life threatening condition or in mass casualty settings, actual body weight cannot be obtained by weight measurement instrument. several resuscitation modalities, such as resuscitation medications, fluid replacement, and amount of electrical shock in defibrillation, are calculated according to patient body weight besides from weight derived from children's parent which cannot achieve in some situations and vary in accuracy, broselow tape is the gold standard currently for appraise children's weight from their length. however, this tape tends to underestimate weight and it is limited to use in children are less than 146 centimeters in length. age- based weight estimation methods are the mathematical formulas to estimate weight from the children's age. the various methods described in the advanced paediatric life support (apls) both original and updated still have doubts about the accuracy and reliability. both length- based and aged- based methods fail to resolve the overweight or obese and underweight children who have the same height or the same age. mercy method is the new weight estimation method that incorporates the humeral length and mid-upper arm circumference to estimate the child weight. this method has been demonstrated both accuracy and reliability over other existing methods. this study will evaluate the validity, reliability and practicality of the previously mentioned pediatric weight estimation methods.

Eligibility criteria:
inclusion criteria: * healthy children * informed consent and assent (7-12 years) were obtained exclusion criteria: * disabling children * incapable to stand up or lie down to measure weight or length * chronic steroid use * edema from known diseases * extremities joint contracture

Keywords: body weight resuscitation pediatric weight estimation
investigation of the etiology of hypertension and endothelial damage in patients with cytochrome p450 oxidoreductase deficiency

Conditions: Cytochrome P450 Oxidoreductase Deficiency; Hypertension; Endothelial Dysfunction; Congenital Adrenal Hyperplasia

Summary: this study investigates the etiology of hypertension and endothelial damage in patients with cytochrome p450 oxidoreductase (por) deficiency. the study involves comparing ambulatory blood pressure monitoring (abpm), endothelial biomarkers (prostaglandin e2, thromboxane b2, and nitric oxide levels), and capillaroscopy findings between por deficiency patients and healthy controls.

cytochrome p450 oxidoreductase (por) deficiency is a rare autosomal recessive condition associated with congenital adrenal hyperplasia and other systemic complications. this study aims to elucidate the role of endothelial dysfunction and hypertension in por deficiency by comparing the biochemical, vascular, and clinical parameters of por-deficient patients with age- and gender-matched healthy controls. the research could pave the way for targeted therapeutic interventions.

Eligibility criteria:
inclusion criteria: * genetically confirmed diagnosis of cytochrome p450 oxidoreductase (por) deficiency * diagnosis of por deficiency before the age of 18. * written informed consent provided by the participant and/or their legal guardian. exclusion criteria: * presence of an acute illness or other pathology identified during the study. nail-biting habit or manicure within the last 14 days (due to potential impact on capillaroscopy results) * use of medications other than physiologic hydrocortisone * kidney, endocrine, or vascular pathologies that may cause hypertension * history of smoking or hand trauma

Keywords: cytochrome p450 oxidoreductase deficiency por deficiency hypertension endothelial dysfunction congenital adrenal hyperplasia
the estrogen replacement and atherosclerosis trial ; primary outcome measure is mean minimal coronary artery diameter after avg of 3.2 yrs.

Conditions: Heart Disease

Summary: background: heart disease is a major cause of illness and death in women. to understand better the role of estrogen in the treatment and prevention of heart disease, more information is needed about its effects on coronary atherosclerosis and the extent to which concomitant progestin therapy may modify these effects. methods: the investigators randomly assigned a total of 309 women with angiographically verified coronary disease to receive 0.625 mg of conjugated estrogen per day, 0.625 mg of conjugated estrogen plus 2.5 mg of medroxyprogesterone acetate per day, or placebo. the women were followed for a mean (±sd) of 3.2±0.6 years. base-line and follow-up coronary angiograms were were analyzed by quantitative methods. follow-up coronary angiograms were obtained after an average of 3.2 years of follow up.


Eligibility criteria:
inclusion criteria: * postmenopausal * not currently receiving estrogen-replacement treatment * one or more epicardial coronary stenoses of at least 30 percent of the luminal diameter, as measured by quantitative coronary angiography exclusion criteria: * known or suspected breast or endometrial carcinoma * previous or planned coronary-artery bypass surgery, * a history of deep-vein thrombosis or pulmonary embolism, * symptomatic gallstones, * serum aspartate aminotransferase level more than 1.5 times the normal value, * fasting triglyceride level of more than 400 mg per deciliter * serum creatinine level of more than 2.0 mg per deciliter * more than 70 percent stenosis of the left main coronary artery, * uncontrolled hypertension, or * uncontrolled diabetes.
energy metabolism for the patients with pulmonary mycobacterium avium complex

Conditions: Pulmonary MAC; Energy Metabolism; Emaciation

Summary: we aim to examine energy metabolism in patients with pulmonary mac and clarify the causes of emaciation. we will also investigate the following: the relation between energy metabolism and degree of pulmonary mac progression; relations among hospitalization, mortality rate, and time-course of changes in energy metabolism; and factors that affect energy metabolism.

patients with pulmonary mac with a lower bmi than healthy individuals also have a significantly poorer prognosis than those of normal weight. emaciation in such patients is thought to be caused by destruction of lung structure from disease progression and an increased resting metabolic rate caused by the increased load from breathing; however, causes of emaciation and details of energy metabolism in these patients have not been studied. elucidating details of energy metabolism and causes of emaciation in patients with pulmonary mac could provide the basis for improvement in nutritional status and activities of daily living through early nutrition therapy and rehabilitation. we propose to clarify the following: energy metabolism in patients with pulmonary mac, including resting metabolic rate, calorie intake and consumption, and hormonal secretions. relation between energy metabolism and degree of pulmonary mac progression.

Eligibility criteria:
inclusion criteria: * subjects with pulmonary mac. exclusion criteria: * subjects with severe cardiovascular disease, diabetes, neurological disease, renal failure, endocrine disease and malignant neoplasm.

Keywords: pulmonary mac energy metabolism
volume controlled ventilation vs autoflow-volume controlled ventilation

Conditions: Prostate Cancer

Summary: volume controlled ventilation(vcv) is a most common used ventilation mode during general anesthesia. but vcv can cause high airway peak pressure when patient under steep trendelenberg position with pneumoperitoneum. autoflow-vcv can reduce airway peak pressure and improve dynamic compliance. we will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied vcv and autoflow-vcv during ralp.

robot assisted laparoscopic radical prostatectomy(ralp) has been used to treatment of prostate cancer since 2001. ralp offers some advantage such as reduced blood loss, sparing nerves, less postoperative pain. however, ralp require steep trendelenberg position with pneumoperitoneum. it can cause increased airway peak pressure and unwanted hemodynamic effect under conventional volume controlled ventilation(vcv). autoflow-vcv use decelerating flow, can reduce airway peak pressure and improve dynamic compliance. we will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied vcv and autoflow-vcv during ralp.

Eligibility criteria:
inclusion criteria: * adult (age 19-65) * american society of anesthesiology classification i-iii exclusion criteria: * cardiovascular disease, cerebrovascular disease, pulmonary disease * over bmi 30
penile intracavernosal stem cells therapy for erectile dysfunction

Conditions: Erectile Dysfunction

Summary: autologous fat derived stem cell treatment of ed. to assess safety and primary efficacy of stem cell infusion in refractory ed. to investigate the success rate and durability of success of using this new therapy in management of moderate and sever cases of erectile dysfunction.


Eligibility criteria:
inclusion criteria: * male 40 years old and older suffering from moderate to sever erectile dysfunction - exclusion criteria: * inability to give informed consent or attend follow up * severe diabetic neuropathy (to be defined ? charcot joints, diabetic ulcers?) or other neuropathic disease * viral disease from infectivity viewpoint * major penile fibrosis or severe peyronie's disease * severe primary large vessel ed (defined as psv less than 15cm/s after ici) * severe primary venous leakage ed (defined as edv more than 10cm/s after ici) * prior systemic chemotherapy, or radiotherapy to donor or recipient area * not in potentially active sexual relationship * age less than 40 or over 70

Keywords: stem cells injections erectile dysfunction