Kornimate/medical-research-clean huggingface dataset:
evaluation of a self-monitoring intervention to reduce safety behavior in social anxiety

Conditions: Social Anxiety

Summary: the current study aims to explore the efficacy of a text message based safety behavior fading intervention compared to an active control intervention.

safety behavior fading may be a viable standalone intervention for social anxiety. in the present trial, participants high in social anxiety will be randomized to either receive a daily checklist exercise aimed at eliminating (1) safety behaviors or (2) unhealthy behaviors. individuals randomly assigned to the safety behavior fading condition will receive instructions to decrease or eliminate their four most habitual social anxiety safety behaviors. in addition, they will receive daily reminders via text message to decrease these behaviors, along with a safety behavior monitoring checklist in which the participant indicates the extent to which they decreased and/or eliminated each safety behavior over the previous day. individuals randomly assigned to the control condition will receive similar text messages and a daily checklist to encourage fading of unhealthy behaviors. participants in both conditions will complete checklists for 28 days. after day 14 of treatment, participants will re-select their target safety behaviors or unhealthy behaviors, and will then be prompted to reduce these new behaviors for another 14 days.

Eligibility criteria:
inclusion criteria: * social phobia inventory score \>29 * stable psychotropic medications for 4 weeks prior to participation exclusion criteria: * currently participating in psychotherapy

Keywords: social anxiety safety behaviors intervention text-message
effect of modified eras protocol on clinical outcomes in pediatric patients with appendectomy

Conditions: ERAS; Surgery; Appendicitis

Summary: acute appendicitis is the most common abdominal emergency with more than 15 million cases reported worldwide. although appendectomy is considered a safe surgical procedure, the incidence of complications is up to 10%. the enhanced recovery after surgery (eras) has developed guidelines to improve postoperative patient outcomes. the protocol, which consists of more than 20 interventions in the preoperative, intraoperative and postoperative periods, shows that early discharge can be possible with multidisciplinary care given to surgical patients without risking patient safety.

appendicitis is a common clinical condition and often requires emergency treatment. although appendectomy is a safe surgical procedure, there is a risk of complications. pain is common, especially in the postoperative period, and the lack of care management leads to delayed mobilization and oral intake, delayed recovery and prolonged length of hospital stay. however, pain, nausea-vomiting, thirst, fear and stress could be managed with perioperative care. in addition, it is reported that the care provided based on the eras protocol shortens the length of hospital stay. in this respect, the aim of this study was to investigate the effect of eras protocol-based care on the length of hospital stay of children who were planned to undergo appendectomy. postoperative pain level, stress and fear level, time to first mobilization, flatulence, defecation and oral intake, nausea, thirst were the secondary outcomes of this study.

Eligibility criteria:
inclusion criteria: * age ≥6 years and ≤18 years, girls or boys * underwent appendectomy * written informed consent or requirements of local/national ethical committee exclusion criteria: * asa (american society of anesthesiologists, asa) score of ≥ 3 * any comorbidity/contraindication that may prevent mobilization and oral feeding

Keywords: appendectomy nurse child pain length of stay anxiety fear vomiting
survey evaluating the psychosocial effects of living with haemophilia

Conditions: Congenital Bleeding Disorder; Haemophilia A; Haemophilia B; Haemophilia A With Inhibitors; Haemophilia B With Inhibitors; Relatives to/Carers of Patients

Summary: this study is conducted in africa, asia, europe, north america and south america. the purpose of the survey is to identify the key psychosocial issues affecting patients with haemophilia.


Eligibility criteria:
inclusion criteria: * males with haemophilia a or b (with or without inhibitors) * parents/carers of children aged below 18 years with haemophilia a or b (with or without inhibitors) * patients currently receiving treatment for haemophilia with one of the following: replacement factor viii or replacement factor ix or a bypassing agent (recombinant factor viia or apcc (activated prothrombin complex concentrate)) * patients with haemophilia, not currently receiving treatment with replacement factor viii or ix or a bypassing agent (as appropriate), but who have had at least one spontaneous bleed into one or more joints within the last 12 months * subjects must have access to the internet, either at home or at a location convenient to them, be able to complete a paper questionnaire, or be available to attend a face-to-face interview (algerian subjects only), to participate in the survey exclusion criteria: * inability to understand and comply with written and verbal instructions unless assisted at the haemophilia treatment centre (htc) or by a relative
endometriosis and atr-ftir spectroscopy

Conditions: Endometriosis; Endometriomas

Summary: the goal of this study is to explore the use of mid-infrared spectroscopy (atr-ftir) as a detection tool for endometriosis in urine.

endometriosis is a chronic gynecological disease that is considered debilitating and multifactorial. its diagnosis is invasive and can be prolonged due to non-specific symptoms and erroneous or late investigations, which can lead to delays and impair the provision of adequate treatment. atr-ftir spectroscopy is a non-invasive technique with the capability to identify the chemical composition and molecular changes of samples through its interaction with mid-infrared radiation. the aim of this work is to develop a rapid test for the detection of endometriosis in urine samples using spectroscopy and machine learning algorithms.

Eligibility criteria:
inclusion criteria: * female * pelvic pain complain exclusion criteria: * age under 18 or above 55 * lack of informed consent

Keywords: endometriosis diagnosis spectroscopy ftir urine detection infrared
the clinical application of tauroursodeoxycholic acid in patients with liver fibrosis.

Conditions: Liver Cirrhosis

Summary: this study is a prospective study. we signed an informed consent form with patients with liver fibrosis and took tauroursodeoxycholic acid orally for half a year. after half a year, liver biopsy was performed using histopathology, immunohistochemistry, and polymerase chain reaction, western blotting method was used to determine the expression level of fibrosis-related markers to verify the effect of taurodeoxycholic acid on patients with liver fibrosis.

tauroursodeoxycholic acid is an effective component of bear bile, which has obvious curative effects in the treatment of gallstones and liver diseases. in recent years, the research field of tauroursodeoxycholic acid has been very active, and its chemical synthesis has also attracted much attention. the usage is swallowing with water before going to bed at night. it must be taken regularly, one capsule at a time (250mg), once a day. after 6 months of continuous use, liver biopsy was performed after 6 months. telling the patient to swallow with water before going to bed at night. it must be taken regularly, one capsule at a time (250mg), once a day. after 6 months of continuous use, liver b-ultrasound biopsy was performed to observe the effect.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of liver cirrhosis and liver fibrosis in patients requiring medical treatment. exclusion criteria: * patients with end-stage cirrhosis, liver failure, etc. who need liver transplantation.
study of a carbohydrate drink in adults

Conditions: Glycemic Response

Summary: the objective of this study is to determine the postprandial glycemic response and rates of gastric emptying in healthy subjects and those with pre-diabetes and type 2 diabetes following oral ingestion of carbohydrate.


Eligibility criteria:
inclusion criteria: * subject has voluntarily signed and dated an informed consent form and provided health insurance portability and accountability act (hipaa) authorization * subject is healthy or has pre-diabetes or type 2 diabetes * subject is a male or a non-pregnant, non-lactating female, at least 6 weeks postpartum * subject's bmi is \> 18.5 kg/m2 and ≤ 40.0 kg/m2 * if subject is on a chronic medication, the dosage has been constant * subject states willingness to follow protocol exclusion criteria: * subject uses exogenous insulin or glucagon-like peptide-1 (glp-1) receptor agonists for glucose control * subject has type 1 diabetes * subject has a history of diabetic ketoacidosis * subject has current infection; has had in-patient surgery, or corticosteroid treatment or antibiotics * subject has an active malignancy * subject has had a significant cardiovascular event ≤ six months or history of congestive heart failure * subject has end-stage organ failure or is status post organ transplant. * subject has a history of renal disease * subject has current hepatic disease * subject has a history of severe gastroparesis * subject has a chronic, contagious, infectious disease * subject has taken/is currently taking any herbals, dietary supplements, or medications that could profoundly affect blood glucose * subject has clotting or bleeding disorders * subject is known to be allergic or intolerant to any ingredient found in the study products * subject is a participant in another study that has not been approved as a concomitant study
post market non-inferiority study comparing triojection® to discectomy for lumbar disc herniation

Conditions: Lumbar Disc Herniation

Summary: the primary objective of this study is to compare the early clinical outcomes following non-surgical treatment with triojection® to surgical discectomy. early is defined as less than or equal to 6 months.

the objective of this study is to compare clinical, economic and safety outcomes between triojection and surgical discectomy. the study will include two follow-up phases: 1) an initial follow-up period during the first 6 months after treatment and (2) a long-term follow-up lasting an additional 18 months (2 years total). the hypothesis is that over the first six months after treatment, triojection® will be non-inferior to discectomy with respect to the improvement in leg pain. this will be demonstrated using a non-inferiority margin of 19.4 points on the difference between baseline leg pain score and the average leg pain score recorded at 1 week, 1, 3 and 6 months.

Eligibility criteria:
inclusion criteria 1. patient is willing to provide informed consent. 2. clinical and radiographic evidence of one, and only one, symptomatic protruding or extruded disc between l1 and s1. 3. the herniated disc should have a disc height of at least 50% that of the normal adjacent disc levels, as determined by the investigator. 4. the signal intensity of the herniated disc material should be equal or greater than the nucleus pulposus of the herniated disc. 5. the patient must have pain in a dermatomal distribution consistent with their radiographic findings 6. leg pain greater than or equal to 5 on the nrs scale 7. symptoms for at least 6 weeks 8. willingness to complete all follow-up evaluations 9. patient aged 18-65 years 10. bmi\<40 exclusion criteria: 1. patients with a disc herniation extending past the facet joint 2. presence of a non-contiguous disc fragment 3. impairment of bladder/bowel function or motor impairment in the affected leg 4. an epidural steroid injection in the past 2 weeks 5. previous discectomy, arthroplasty or fusion at any lumbar level 6. in patients with l5-s1 disc herniation, a congenital condition where the l5 vertebral body is either fused to the sacrum or the l5-s1 disc is not fully formed as a normal adult disc. 7. symptomatic lumbar stenosis or listhesis 8. symptomatic sacroiliac joint 9. symptomatic foraminal stenosis due to severe degenerative disc disease 10. history of spinal tumor, fracture or infection 11. females of childbearing age that are known to be pregnant or wishing to become pregnant during the study 12. fibromyalgia 13. active infection 14. metastatic cancer within the past 5 years 15. pending litigation against a health care provider 16. more than 3 months of continuous sick leave prior to enrollment. 17. known drug or alcohol abuse 18. diagnosed psychiatric disease or psychological distress caused by recent trauma like divorce, death of a member family or loss of a job 19. patient known to be affected by favism (g6pd deficiency)

Keywords: disc herniation herniated disc triojection ozone lumbar spine leg pain
comfort: a multicenter, open-label, randomized, crossover study

Conditions: Varicose Veins

Summary: the purpose of this study is to evaluate pain the patient experienced following treatment of varicose veins with varithena® compared to radiofrequency ablation.

a study that evaluates pain following treatment of varicose veins in patients treated with varithena® and those treated with rfa.

Eligibility criteria:
inclusion criteria: 1. men and women; age 18 to 75 years 2. bilateral incompetence of sfj (reflux \>1 second on duplex ultrasonography) associated with incompetence of the gsv in both legs 3. gsv diameter \>5 mm measured from the superficial epigastric vein to 10 cm below the sfj while in a standing position in both legs 4. eligible to receive rfa treatment and varithena® treatment 5. ceap c2-c5 (inclusive) 6. patient is participating in usual work and home activities with no changes anticipated for the duration of the study 7. ability to comprehend and sign an informed consent and complete study questionnaires written in english 8. ability to reliably use an electronic diary to record pain and analgesic/opioid use in accordance with the protocol exclusion criteria: 1. prior gsv treatment in either leg 2. non-venous source of pain in either leg that could confound the results of the study 3. use of chronic analgesic or opiate medications or medical history that could result in the regular use of pain medications during the study 4. history of deep vein thrombosis, pulmonary embolism or stroke, including evidence of prior or active dvt on duplex ultrasound 5. deep venous reflux unless clinically insignificant in comparison to superficial reflux 6. inability to wear post-procedure compression bandaging and stockings 7. reduced mobility (unable to walk unaided for 5 minutes per waking hour) 8. major surgery, prolonged hospitalization or pregnancy within 3 months of screening 9. major co-existing disease (e.g., malignancy; pulmonary disease; renal or hepatic insufficiency; serious skin disease/condition that may compromise the ability of the patient to comply with the compression protocol, etc.) 10. contraindications to varithena® (e.g., acute thromboembolic disease) or rfa according to the manufacturer's prescribing information 1. varithena® contraindication due to known allergy to polidocanol 2. rfa contraindication due to veins being too large 3. rfa contraindication due to veins being too tortuous 11. known allergic response to polidocanol and/or multiple allergic reactions 12. current or history of alcohol or drug abuse 13. pregnant or lactating women 14. women of childbearing potential not using effective contraception for at least one month prior to study treatment and/or unwilling to continue birth control for the duration of the study 15. participation in a clinical study involving an investigational pharmaceutical product or device within the 3 months prior to screening
gradual vs. rapid buprenorphine detoxification - 2

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to determine an optimal detoxification dose reduction schedule with buprenorphine.


Eligibility criteria:
please contact site for information.
subjective ageing in fibromyalgia

Conditions: Fibromyalgia

Summary: subjective age or felt age is the term used for how the person feels; one can feel same, younger or older than their actual age. feeling younger or feeling older may be associated with depression, anxiety, fatigue, sleep, quality of life or cognitive function.

in this cross-sectional study, the investigators hypothesized that fibromyalgia patients mostly feel older than their actual age and this felt age may be associated with depression, anxiety, fatigue, sleep, quality of life or cognition. after power analysis, study sample calculated as 262 patients, the present study will use 2016 revised american college of rheumatology criteria to diagnose fibromyalgia.

Eligibility criteria:
inclusion criteria: * fibromyalgia diagnosis using 2016 revised american college of rheumatology * aged \>18 years old * widespread pain more than 3 months exclusion criteria: * any disease that can cause depression, anxiety, fatigue, poor sleep quality or poor cognitive function except from fibromyalgia.

Keywords: anxiety cognitive ageing depression fatigue fibromyalgia quality of life sleep
social inequalities in the participation and activity in children and adolescents with hodgkin-lymphoma

Conditions: Classical Hodgkin Lymphoma

Summary: purpose of this study is to determine the influence of social factors on participation and activity among children and adolescents aged 10-18 years with hodgkin-lymphoma. furthermore personal and treatment-related factors and their impact on participation will be explored.

hodgkin-lymphoma is a rare malignancy among children and adolescents (about 140 each year in germany) which is highly curable. beside this therapeutic success, a lot of therapy-related long-term problems arise (e.g. fertility disorders, thyroid diseases, secondary malignancies). while most of the studies focused on mental and physical impairments, little attention has been drawn to social dimensions of health. due to the disease and the requirements of the therapy, participation of children with hodgkin-lymphoma can be impaired acutely or chronically. this can be of serious consequences, because participation in daily life is an important component of the development of children and adolescents. to determine the influence of social, personal and treatment-related factors on participation, all patients who were actual treated in the international therapy study euronet-phl-c2 in all of germany (n ≈ 700) and their parents will be interviewed. statistical analyses will be done using descriptive and multivariate methods taking account of treatment-related issues (e.g. stage of disease, chemotherapy, radiotherapy, progression/relapse).

Eligibility criteria:
inclusion criteria: * histologically confirmed primary diagnosis of classical hodgkin's lymphoma * 10-18 years * written informed consent of the patient and/or the patient's parents or guardian according to national laws exclusion criteria: * other (simultaneous) malignancies

Keywords: social participation children and adolescents with cancer quality of life with hodgkin-lymphoma social inequalities and cancer
the efficacy of plastic stent anchoring to reduce migration of metal stent

Conditions: Malignant Biliary Stricture

Summary: the aim of this study is to demonstrate that the group with an additional plastic stent to anchor the fully covered self expandable metal stent (fcsems) in patients with malignant biliary stricture has less stent migration than the group with fcsems only. the primary outcome is stent migration for 6 months. the secondary outcomes are stent related adverse events, stent patency, and overall survival.

endoscopic retrograde biliary drainage using a plastic stent for the treatment of malignant biliary stricture has advantages in that it is easy to perform and low cost, but it has a short period of patency. to overcome this drawback, self-expandable metal stents (sems) have been developed and are now widely used. but, over time, the sems also develop restenosis, due to tumor ingrowth and the tissue hyperplasia caused by the stimulation of the surrounding tissues by the metal thin wire. to overcome these disadvantages, a fully covered self-expandable metal stents (fcsems) covered with a polymer coating have been developed and used. however, the fcsems showed more stent migration than the uncovered sems, which was not superior to the uncovered sems in terms of loss of stent function. in order to overcome the limitations of the fcsems, small-scale studies have shown that stent migration can be reduced by anchoring the fcsems using a plastic stent. to date, there has been no randomized controlled study to determine whether the fcsems can be anchored with a plastic stent in patients with malignant biliary stricture to reduce the stent migration. therefore, the purpose of this study is to evaluate the efficacy of plastic stent anchoring to reduce migration of fcsems.

Eligibility criteria:
inclusion criteria: * malignant biliary stricture requiring biliary drainage through endoscopic procedure exclusion criteria: * previous history of metal stent placement for malignant biliary stricture * hilar cholangiocarcinoma * malignant biliary stricture of intrahepatic duct * a recurrence after surgery due to malignant biliary stricture * life expectancy less than 3 months * pregnancy * if endoscopy is not possible based on the judgement of the researcher
effect of group preoperative pelvic floor training for holep

Conditions: BPH; Urinary Incontinence

Summary: the main goal of this study is to see if group pelvic floor training before surgery can help prevent urinary incontinence after holmium laser enucleation of the prostate (holep) surgery. the study has the potential to inform preoperative intervention strategies for managing incontinence after holep.

preoperative pelvic floor training (pft) may improve early urinary incontinence after prostate surgery. group-based training potentially provides additional benefits such as cost-benefit, social support, and motivation. however, the efficacy of group preoperative pft has not been reported. this study aims to determine the effect of group preoperative pft on transient urinary incontinence after holep in a prospective cohort of patients and to identify any potential predictors of transient urinary incontinence after holep. in this study, the investigators will recruit approximately 50 patients in each cohort (total 100) and will be followed over time to collect data on both the exposure (group pft) and the outcome (incidence of urinary incontinence 1 month and 3 months after holep). potential confounding variables, such as patient demographics, preoperative imaging, and operative data, will be collected and analyzed. the results of this study have the potential to inform the development of effective preoperative interventions for the management of transient urinary incontinence after holep.

Eligibility criteria:
inclusion criteria: * consecutive patients with a diagnosis of bph with a plan to undergo holep. * between the age of 50-90. * ability to understand and provide informed consent. exclusion criteria: * patients whom inability to carry out pft protocol. * patients unwilling or unable to complete follow up care. * severe urinary incontinence due to a history of neurological diseases such as a cerebrovascular accident or spinal cord injuries. * patients whom inability to read and understand the english language.

Keywords: benign prostatic hyperplasia pelvic floor training group therapy holmium laser enucleation of the prostate urinary incontinence