Kornimate/medical-research-clean huggingface dataset:
a positioning navigation template for assisting the placement of modular hemipelvic endoprostheses for patients undergoing pelvic bone tumor resection.

Conditions: Pelvic Tumor

Summary: background: acetabular reconstruction in situ after extensive pelvic resection is technically challenging because the significant loss of bone stock and bony landmarks. the aim of the present study was to investigate the feasibility of an individualized navigation template for acetabular reconstruction following pelvic malignancy resection. methods: this retrospective cohort study included patients who underwent type ii or ii+iii pelvic tumor resection and reconstruction using a modular hemipelvic prosthesis. in the template-guided group (n = 10), a navigation template was designed and applied to assist acetabular reconstruction. in the traditional operation group (n = 14), the patients underwent the same surgery but without the navigation template. to compare the displacement of the hip rotation center before and after surgery between the two groups, an innovative method based on pelvic ct was developed and a validation group of cases was used to assess the effectiveness of this measurement approach. in the validation group (n = 12), patients undergoing periacetabular puncture or curettage without hip joint reconstruction were included. the displacements for the validation group were calculated and compared with 0 cm, the theoretical value. subsequently, the displacements between the template-guided group and the traditional operation group were compared.


Eligibility criteria:
inclusion criteria: 1. all the patients diagnosed with a pelvic tumor； 2. underwent limb salvage surgery following type ii or ii+iii pelvic resection； 3. acetabulum reconstruction using a modular, titanium hemipelvic prosthesis. exclusion criteria: 1. a lack of postoperative ct images; 2. having undergone revision surgery or noninitial/primary resection; 3. unable to calculate the hip displacement by the specific measurement method we proposed.

Keywords: pelvic tumor acetabular reconstruction navigation template hip rotation center placement in situ
etude 3000 arthroses symptomatic knee and hip osteoarthritis prevalence survey

Conditions: Osteoarthritis

Summary: nationwide descriptive epidemiology survey aiming to determine lower limb oa prevalence, based on a validated method previously used to assess inflammatory rheumatism (rheumatoid arthritis and spondylarthropathy) prevalence in france.

osteoarthritis (oa) is a degenerative disease progressively affecting joint cartilage and subchondral bone, leading to pain, limited range of motion and functional impairment. knee and hip are the more frequently affected joints. there is no treatment able to cure oa or at least to slow down cartilage damage. thus, when symptomatic treatments become ineffective, joint prosthetic replacement is the unique solution. there is a substantial lack of information about osteoarthritis (oa) epidemiology in france, as well as in other european countries, which becomes more and more critical with population aging. the need for additional knowledge was outlined in the law about public health priorities in france, published on august 9th, 2004. in this document, a specific call is made for additional investigation on functional limitations, disability and quality of life modification of people affected by oa. up to now, available information is mainly limited to short- or medium-term studies, conducted in clinic-based samples. thus, based on demography and public health conclusions, implementing population-based epidemiologic studies is required in order to improve scientific knowledge with regards to : * prevalence of symptomatic oa, * its natural history over years and potential prognostic factors influencing the disease, * its impact in terms of quality of life changes, disability, lack of autonomy and health resource use. our expert group, which has a substantial experience in osteoarthritis, epidemiology and health service research, has developed a 2-part research program aiming to help answering to oa-related public health questions: * part 1: a nationwide descriptive epidemiology survey aiming to determine lower limb oa prevalence, based on a validated method previously used to assess inflammatory rheumatism (rheumatoid arthritis and spondylarthropathy) prevalence in france. * part 2: the constitution of a population-based cohort of oa patients, aiming to collect clinical, biologic and radiological data about oa natural history, predictors of structural progression, consequences on quality of life, function and health resource use. the present study is the part 1 of the program

Eligibility criteria:
inclusion criteria: * age 40-75 * adults in households representative of the french population for age, sex, area of living and number of household members. exclusion criteria:

Keywords: osteoarthritis knee hip population based
methylation status of cd44 promoter region in primary lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: this project is to study the methylation status of the transcriptional regulatory region of cd44 gene in surgically resected nsclc specimens and normal lung tissue, correlate the methylation status of promoter region with the expression of cd44 gene, and analyze if methylation is associated with survival.

cd44 is a cell surface receptor for the extracellular matrix hyaluronan. it mediates adhesion of cells to the extracellular matrix. its ability to organize extracellular matrix into a medium is also used by cancer cells in their becoming metastatic. invasive tumor cells are frequently observed to bind hyaluronate. cd44 gene is made up of 20 exons, at least 10 of which are variably expressed due to alternative splicing of the mrna. the standard form, cd44s, has a coding sequence of exons 1-5 and 16-20. variant isoforms (cd44v), all larger, arise from alternative splicing of combinations of exons 6-15 (v1-10). a variant isoform cd44 can induce metastasis of a rat pancreatic carcinoma. studies in human tumors, however, have produced variable results. some breast cancers demonstrate positive correlation between cd44v expression and tumor progression, while others lack any correlation. some colorectal tumors even show an inverse correlation. cd44 has also been demonstrated to be a metastasis suppressor gene for prostate cancer. thus, cd44 may be a marker for metastasis for some tumors, but not for others, and it may actually be a metastasis suppressor gene for yet another groups of tumors. for primary lung cancer, the correlation between cd44 expression and tumor metastasis has not been established. the metastasis-prone small cell lung cancer rarely showed any immunohistochemical staining for cd44s or cd44v. for non-small cell lung cancer (nsclc), some studies showed positive correlation between immunohistochemical cd44v expression and tumor progression, while others showed no correlation. our own study using rt-pcr, sequencing and immunohistochemical staining showed that in pulmonary adenocarcinoma, cd44v6 expression is down-regulated as the disease progressed. based on our finding, and the observation that cd44s and cd44v expression are low in metastasis-prone small cell lung cancer, we assue that cd44 is a metastasis suppressor gene which is inactivated in lung cancers. because in prostate cancer dna hypermethylation has been shown to be related to the down-regulation of cd44 gene, we plan to study the methylation status of the transcriptional regulatory region of cd44 gene in primary lung cancer. we'll study cd44 expression by immunohistochemistry, the methylation status of cd44 regulatory region by sequencing of the bisulfite-modified genomic dna, and correlate these two findings with each other, and with histologic type, tumor staging and survival.

Eligibility criteria:
inclusion criteria: * non-small cell lung cancer exclusion criteria: * no
burnout syndrome among medical residents

Conditions: Burnout Syndrome

Summary: whether and to what extent burnout risk is actually higher in surgical specialties than in non-surgical specialties is still unknown. little is also known about what factors are associated with burnout between surgical residents and non-surgical residents. in this context, the present study has a three-fold aim: 1) to measure the prevalence of burnout among a sample of italian medical residents; 2) to contrast the prevalence of burnout and psychological distress in surgical residents and non-surgical residents, and 3) to identify the work-related factors associated with burnout between surgical residents and non-surgical residents.

surgical training is considered to be very stressful among residents and graduating medical students choose less often surgery for their career. to elaborate burnout prevention programs, the assessment of the prevalence of burnout during the early career stage of the surgeons and associated risk factors, becomes central. residents from the university of bologna were asked to participate in an anonymous online survey. the residents completed a set of questions regarding their training schedule and three standardized questionnaires: 1) the maslach burnout inventory, assessing the three dimensions of burnout: emotional exhaustion (ee), depersonalization (dp), and personal accomplishment (pa); 2) the zung self-rating depression scale; 3) the psychosomatic problems scale. high scores in either the ee or dp subscale categories predicted professional burnout.

Eligibility criteria:
inclusion criteria: * residents attending the university of bologna exclusion criteria: * none

Keywords: burnout residents surgical residents
hull airway reflux questionnaire scores following cough treatment

Conditions: Cough

Summary: the aim of this study is to have those patients taking part in the clinical trial-: a multicentre, double-blind, placebo-controlled, pivotal study of the efficacy and safety of oral theobromine in the management of cough. complete the hull airway reflux questionnaire (harq) at randomisation and repeat the questionnaire at the end of the 14 day treatment period. the investigators hope to demonstrate a clinically significant change in harq scores of at least 16 points from before and after treatment. furthermore the investigators would hope to show a significantly improved harq score in patients on the bc036 arm of the study compared to the placebo arm.


Eligibility criteria:
inclusion criteria: 1. male/females meeting eligibility criteria for study: - a multi-centre, double-blind, placebo-controlled, pivotal study of the efficacy and safety of oral bc1036 in the management of cough. 2. willing and able to comply with study procedures 3. able to provide written informed consent to participate exclusion criteria: 1. any subject meeting any exclusion criteria on the study "a multi-centre, double-blind, placebo-controlled, pivotal study of the efficacy and safety of oral bc1036 in the management of cough." will be excluded from this study.

Keywords: chronic cough
implementation of an asthma program to improve asthma identification and education in children

Conditions: Asthma; Hypertension; Obesity

Summary: the primary objective of this study is to document the prevalence and associations between asthma, hypertension, and obesity in children living in pittsburgh, pennsylvania and its surrounding regions. the secondary objective is to determine the impact of various educational interventions on child and caregiver knowledge of asthma.

the asthma program will consist of six screenings and three camps each year, for two consecutive years. screenings will be conducted in areas where populations are known to be at increased risk for asthma and its complications, such as inner-city, lower socioeconomic, african-american populations. screenings will be conducted at churches or schools in these areas one month prior to each camp in an effort to identify children with undiagnosed or uncontrolled asthma and refer them to the camps. camps will also be conducted in areas where populations are known to be at increased risk for asthma and its complications to improve ease of access. asthma and smoking cessation education will be provided at each camp to children and caregivers. baseline data will be collected at each camp and assessed. longitudinal clinical outcomes will be assessed in children attending multiple camps.

Eligibility criteria:
inclusion criteria: * children, ages 5- 17 years attending the asthma camps and screenings. exclusion criteria: * children younger than 5 years of age and adults 18 years of age and older.
arterial wall calcium load in pseudoxanthoma elasticum

Conditions: Pseudoxanthoma Elasticum; Type 2 Diabetes; Chronic Kidney Disease

Summary: quantification and preferential sites of arterial wall calcification within the coronary and lower legs arteries will be comared between pseudo-xanthoma elasticum(pxe) atients and type 2 diabetics and chronic kidney disease.

in a previous work we have observed that patients suffering from pxe, a soft-tissue calcifying inherited autosomal disease, exhibited specific structural and functionnal features within the peripheral arteries. we now want to quantify and determine the preferential sites of the arterial wall calcification (agatston score) between these patients compared to diabetics and patients with chronic renal insufficiency with mediacalcosis. all variables will be collected from a cohort of pxe monitored in our pxe health and care centre at the university hospital of angers. quantification of the arterial wall calcium load will be performed using helicoidal ct-scan. these variables will be compared to the same measurements performed in type 2 diabetic and chronic kidney disease patients paired by age and gender.

Eligibility criteria:
inclusion criteria: * patients with phenotypically and genotypically-proven pxe * type 2 diabetic patients with mediacalcosis (i.e. ankle brachial index \> 1.30) * patients with a chronic kidney disease (ckd), before kidney transplantation * all patients should be affiliated to a health care system exclusion criteria: * patient with unproved pxe * patient under the age of 18 yrs * patient unwilling to participate to the study * pregnant women * patient not affiliated to a health care system
copd care pathway among patients with cancer

Conditions: Chronic Obstructive Pulmonary Disease; Lung Cancer; Head and Neck Cancer

Summary: this study gathers information for the development of a copd care pathway for patients with cancer that reduces the treatment burden of patients, implements critical components of copd care, and overcomes common barriers to copd care in the community oncology clinic.

primary objective: to design a feasible copd care pathway for patients with cancer that reduces the treatment burden of patients, implements critical components of copd care, and overcomes common barriers to copd care in the community oncology clinic. secondary objectives: * to identify, characterize, and explain the treatment burdens of copd and cancer as comorbidities, as reported by patients and providers. * to identify, characterize, and explain barriers to copd care in the oncology clinic, as reported by patients and providers. * to identify, characterize, and explain important and feasible components of copd care for patients with cancer.

Eligibility criteria:
inclusion criteria: * the participant has personal experience with medical management of copd, defined as meeting at least one of the following criteria: 1. patient with clinical documentation of copd (either as a confirmed or suspected diagnosis) and has received at least one dose of an immune checkpoint inhibitor for cancer or 2. provider who currently works at least part-time in a medical oncology clinic or 3. provider who works at least part-time to care for patients with known or suspected copd. a suspected diagnosis of copd can be based on finding(s) by history, exam, or radiography (e.g., ct changes such as emphysema, bronchial wall thickening, or mucus plugging). a provider is defined as a physician, advanced practice provider, nurse, or respiratory therapist. study team members are permitted to participate in the study if they meet eligibility criteria. * ability to understand and agree to participate on the study as described by the study information sheet. * capability of speaking or reading english. exclusion criteria: severe psychiatric symptoms; unusual social situation; or critical instability that would limit adherence to the study requirements, as determined by the study team.
neurofeedback and neural plasticity of self-processing and affect regulation circuits in suicide attempting adolescents

Conditions: Suicide, Attempted; Suicide, Ideation; Depression

Summary: a non invasive treatment study including participants at risk for suicide attempts and undergoing neurofeedback training. neurofeedback is controlling your brain activity in real time inside the scanner.


Eligibility criteria:
inclusion criteria: * adolescents with a history of suicide attempts exclusion criteria: * psychotic disorders. * primary substance use disorder. * primary anorexic disorder. * autism spectrum disorder.
study to compare amg 510 "proposed inn sotorasib" with docetaxel in non small cell lung cancer (nsclc) (codebreak 200).

Conditions: KRAS p, G12c Mutated /Advanced Metastatic NSCLC

Summary: a phase 3 study to compare amg 510 with docetaxel in non small cell lung cancer (nsclc) subjects with kras p. g12c mutation


Eligibility criteria:
inclusion criteria: * men or women greater than or equal to 18 years old. * ecog ≤ 1 * pathologically documented, previously treated, locally-advanced and unresectable or metastatic nsclc with kras p.g12c mutation confirmed through central testing or have documentation of kras p.g12c mutation through amgen study 20190294 prior to enrollment exclusion criteria: * active brain metastases * myocardial infarction within 6 months of study day 1 * gastrointestinal (gi) tract disease causing the inability to take oral medication
mindfulness based intervention on the covid-19 related distress and mobile addiction

Conditions: Psychological Stress

Summary: the interventional study would be conducted to investigate the efficacy of mindfulness based intervention in order to treat psychological stress(anxiety, depression, and stress related covid-19), and mobile phone addiction during covid-19 pandemic.

in the current study the data was collected from the young adults (age range 19-35 years). the high scorer from the sample selected from the participants in both control and experimental groups. furthermore, the mindfulness based stress reduction intervention was given to the experimental group. the mindfulness based stress reduction intervention comprised eight weeks period. after the provision of intervention the data for the second phase would be collected.

Eligibility criteria:
inclusion criteria: * the participants fulfil the age criteria, students from public and private universities, and provided signed informed consent. exclusion criteria: * participant suffering from chronic physical or psychological disorder. in addition participant who experience death of loved ones during covid-19 pandemic.

Keywords: psychological stress mobile phone addiction
calgary registry for advanced and therapeutic endoscopy

Conditions: Biliary Disease; Pancreatic Diseases

Summary: the aim of the calgary registry for advanced and therapeutic endoscopy (create) is to be a high-fidelity prospective multi-centre registry. the study population consists of consecutive adult ercp patients from september 2018 to august 2022. informed consent is acquired for each patient. all relevant pre-procedural, procedural, peri-procedural and post-procedural data are captured in real time by a full-time third-party research assistant directly observing procedures. outcomes are ascertained by comprehensive medical record review and patient phone interview 30 days after the index procedure. this registry also serves as a secure data collection platform for several currently recruiting prospective studies and randomized trials.


Eligibility criteria:
inclusion criteria: * any standard indication for ercp, in the absence of standard contraindications; * age 18 years or over; * ability and willingness to give informed consent to be included in the registry and/or to involvement in one (or more) prospective sub-studies, or accompaniment by a surrogate who is willing and able to provide consent. exclusion criteria: -none other than inverses of above.
sinus augmentation in the posterior maxillary region: a case report of 0mm bone height.

Conditions: Bone Resorption

Summary: sinus floor elevation (sfa) and gbr have been applied in the placement of dental implants in longstanding edentate posterior maxilla region. however, the number of study on the efficacy of these procedure on areas with 0mm bone height is limited. this case study aims to compare two cases of 0mm bone height in the posterior maxillae region with different handling procedure. in this article, two female patients in their 40s underwent maxillary sinus augmentation (sinus lifting) due to longstanding missing posterior maxillary molars with the bone of which area had resorbed entirely, leaving 0mm bone height. one patient went through conventional sinus augmentation while the other had a two-stage - sinus - lift procedure. researchers compared the bone - volume induced between the two procedures.


Eligibility criteria:
inclusion criteria: * 0mm bone height at posterior maxillae region exclusion criteria: * general contraindication to implant surgery * subjected to irradiation in the head and neck area \<1 one year before implantation * uncontrolled diabetes * pregnant or nursing * substance abuse * heavy smoker * psychiatric therapy or unrealistic expectations * immunosuppressed or immunocompromised * treated or under treatment with oral or intravenous aminobisphosphonates * untreated periodontitis * poor oral hygiene and motivation
comparative study of oral anticoagulation in left ventricular thrombi

Conditions: Anticoagulants; Increased; Left Ventricular Thrombosis

Summary: left ventricular (lv) thrombus is a common problem that is encountered in patients who survived from a large myocardial infarction, and distal systemic embolization is the main issue in these patients due to its major clinical consequences especially cerebrovascular stroke. novel oral anticoagulants (noacs) are now used safely in nonvalvular atrial fibrillation, these agents were shown to be at least as effective as vitamin k antagonists (vka) such as warfarin in prevention of systemic embolism, while having an improved safety profile with less bleeding risk. however, the data about their usage for lv thrombi instead of the commonly used vka are still lacking except for case reports and small case series. the proposed aim of this randomized observational clinical trial is to assess the efficacy of the conventional anticoagulation in the form of warfarin and noacs in the form of rivaroxaban in the treatment of lv thrombus.

the proposed aim of this randomized observational clinical trial is to assess the efficacy of the conventional anticoagulation in the form of warfarin and noacs in the form of rivaroxaban in the treatment of lv thrombus. so patients with actual lv thrombus will be divided into 2 groups, one will receive the traditional therapy which is warfarin with follow up of the inr in order to reach the desired level of 2-3 then follow up every two weeks to determine the time in therapeutic range until the end of the study follow up. the other group will receive oral rivaroxaban 20 mg per day with follow up for the persistence or the disappearance of the lv thrombus one month, three months and 6 months later. as a secondary and safety end point, any major bleeding will be recorded as well as any thrombo-embolic events

Eligibility criteria:
inclusion criteria: * evidence of lv thrombus as assessed by trans-thoracic echocardiography (tte). exclusion criteria: * creatinine clearance less than 50 ml/min.

Keywords: warfarin rivaroxaban left ventricular thrombus