Kornimate/medical-research-clean huggingface dataset:
readmission risk factors and heart failure with preserved ejection fraction

Conditions: Heart Failure; Preserved Ejection Fraction

Summary: retrospective review of 492 patient from a small community hospital who did not qualify for participation in the connect hf study sponsored by dcri.

retrospective review of adults above the age of 18 with a primary diagnosis of hfpef between august 2017 and march 2018. subjects had to fall into one of two classifications (nyha class ii-iv or acc/aha stage b-d) and had a life expectancy greater than 6 months are included. individuals with a terminal illness other than hf, prior heart transplant or on a transplant list, or current/ planned left ventricular assist device excluded. the primary objective of this study is to identify risk factors for readmission in patients discharged with a diagnosis of hfpef.

Eligibility criteria:
inclusion criteria: * history of heart failure diagnosis admitted for treatment * ejection fraction \< 40% by echocardiogram exclusion criteria: * ejection fraction \>40% by echocardiogram * chronic kidney disease requiring dialysis * terminal illness * new onset diagnosis of heart failure

Keywords: heart failure readmission risks
cerebral effects of pegylated interferon in hepatitis c positive subjects

Conditions: Hepatitis C

Summary: the hypothesis of this study is that pegylated interferon would cause cognitive deficits and mood changes in hepatitis c (hcv) positive subjects.

subjects with non-cirrhotic hepatitis c will have a magnetic resonance imaging (mri)/magnetic resonance (mr) spectroscopy and neuropsychological testing prior to starting interferon. subjects will have repeat testing following 12 weeks of interferon therapy and again at 12 weeks post interferon therapy. mr spectroscopy (mrs) will measure the cerebral metabolites, naa (n-acetyl aspartate), cho (choline), mi (myoinositol) and cr (creatine) at 3 distinct brain regions, i.e. basal ganglia and 2 locations within the frontal cortex. neuropsychological testing will include tests of the following cognitive domains: executive functioning, memory, language, motor skills and will also include questionnaires pertaining to quality of life (sf-36), mood (beck's depression inventory) and a self-rating cognitive questionnaire (conners' adult attention deficit hyperactivity disorder rating scales \[caars\]). control subjects will include non-cirrhotic hcv subjects who are not taking interferon therapy.

Eligibility criteria:
inclusion criteria: * adults (\>18 years old) of both sexes with chronic hcv infection (all genotypes). * subjects due to start treatment with pegylated interferon-alpha (ifn-a) for hcv eradication. * subjects with chronic hepatitis c who have elected not to be treated with pegylated-ifn-a * subjects with mild fibrosis on liver biopsy (stage 0-iii/iv fibrosis) * subjects able to give informed consent. * subjects with controlled depression currently taking anti-depressant medication. exclusion criteria: * subjects with cirrhosis on liver biopsy. * subjects with active alcohol or drug abuse. * subjects co-infected with human immunodeficiency virus (hiv). * subjects with structural brain abnormality, past history of cerebrovascular accident (cva) or serious head trauma. * subjects with seizure disorder. * subjects with any contraindication to ifn therapy. * subjects with a poor command of the english language. * subjects with a contraindication to mri, e.g. pacemaker, claustrophobia.
fibrin glue vs. suture in pterygium surgery

Conditions: Conjunctival Autograft

Summary: the use of fibrin glue to place conjunctival graft will be as effective as suturing the graft, but will require much less operative time and will be better tolerated by the patients.

pterygium surgery requires removal of the pterygia from cornea and conjunctiva and an additional technique to prevent recurrence which may be as high as 50%. suturing a conjunctival auto-graft has become one of the most popular and effective methods in preventing recurrence. however suturing requires long operative time (10-20 minutes with removal alone less than 5 minutes) and requires sutures removal after 1-2 weeks which is very inconvenient to the patient. using fibrin glue (quixil) has been used in several places in pterygium surgery and we believe it will be as effective as suturing the graft, will use much less or time (reduce surgery time from 40 minutes to 20-25 minutes) and will be less expensive since 2 ml glue (around 80us$) suffice for 10 cases, while one vicryl suture costs around 34 us$.

Eligibility criteria:
inclusion criteria: * primary pterygium * healthy subject * ability to attend follow-up visits exclusion criteria: * recurrent pterygium * underwent previous surgery / intervention to treat pterygium * ocular surface disease 0 minor

Keywords: pterygium conjunctival graft recurrence primary pterygium
safety, tolerability and immunogenicity of two different formulations of meningococcal b recombinant vaccine, when administered to healthy infants

Conditions: Meningococcal Disease

Summary: to explore safety, tolerability and immunogenicity of two formulations of a meningococcal b recombinant vaccine when administered to healthy infants.


Eligibility criteria:
inclusion criteria: * healthy 6-8 months old infants exclusion criteria: * previous receipt of any meningococcal b vaccine; * previous ascertained or suspected disease caused by n meningitidis; * history of any anaphylactic shock, asthma, urticaria or other allergic reaction after previous vaccinations or known hypersensitivity to any vaccine component; * any present or suspected serious acute or chronic disease * known or suspected autoimmune disease or impairment /alteration of immune function

Keywords: meningococcal disease, prevention, vaccination
feasibility and preliminary effects of the resilience-based, energy management to enhance wellbeing in systemic sclerosis (renew) intervention

Conditions: Scleroderma

Summary: researchers are testing a web-based peer-led program to help manage energy and symptoms in people who have scleroderma. resilience-based, energy management to enhance wellbeing (renew) was created by researchers, doctors, and patients with scleroderma. the goal is to help people with scleroderma feel better.


Eligibility criteria:
inclusion criteria: * have a diagnosis of systemic sclerosis including: * diffuse or limited cutaneous * have access to a reliable, internet-connected device (e.g. computer, tablet) * be able to read, speak, and understand english * participants need to report a score of at least 4 on a scale of 0 - 10 of fatigue severity, a cut-off for at least moderate fatigue in other fatiguing conditions. exclusion criteria: * complex, unstable health issues that would preclude full participation in the study * planning to start new treatment for fatigue, pain, mood during the study period

Keywords: peer mentor web-based
proton beam radiotherapy for medulloblastoma and pineoblastoma

Conditions: Brain Tumor; Medulloblastoma; Pineoblastoma

Summary: there are two types of external radiation treatments (proton beam and photon beam). as part of the participant's treatment, they will receive radiation to the entire central nervous system (cns); this is known as craniospinal irradiation (csi). in the past, photon radiation therapy has been used for csi. in this study we will be examining the effects of proton beam radiation therapy. studies have suggested that this kind of radiation can cause less damage to normal tissue than photon radiation therapy. the physical characteristics of proton beam radiation let the doctor safely deliver the amount of radiation delivered to the tumor that is normally delivered through standard therapy but spare more normal tissue in the process.

* before beginning radiation therapy, participants will have scans done in order to prepare for the radiation treatment. doctors will use information gathered from these scans to plan the best way to deliver radiation to the tumor. * the following procedures will be performed either before or during the radiotherapy: hearing exam; neurocognitive exam; blood tests and cerebral spinal fluid test. * not everyone who participates in this study will receive the same amount of proton radiation therapy. the length of time and amount of radiation received will depend upon the condition of the participant's disease. radiation treatment will be given once a day, 5 days a week (monday-friday). the overall treatment course will be approximately 6 weeks.

Eligibility criteria:
inclusion criteria: * participants must have undergone biopsy or attempted surgical resection and must have histologically confirmed medulloblastoma or pineoblastoma. * participants may have had a gross total resection, sub-total resection or biopsy only. * for patients with no prior chemotherapy, treatment must start within 35 days of definitive surgery or as indicated if enrolled on therapeutic study * age range between 3 and 25 at the time of enrollment * life expectancy of greater than 3 months * blood laboratory values as outlined in the protocol * women of child-bearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation exclusion criteria: * patients with more than one previous chemotherapy regimen * patients with recurrent or progressive disease after one or more regimens of pre-radiation chemotherapy * patients with prior radiation therapy * any major uncontrolled or poorly controlled intercurrent illness that would limit compliance with study requirements * pregnant women

Keywords: proton beam radiation
effect of postbiotic product on colonic barriers in ibs

Conditions: IBS - Irritable Bowel Syndrome

Summary: impaired intestinal permeability and microbial dysbiosis are important pathophysiological mechanisms underlying irritable bowel syndrome (ibs). referm®, also called profermin®, is a postbiotic product of oat gruel fermented with lactobacillus plantarum 299v. in this experimental study, we investigated whether referm® has a beneficial effect on the intestinal epithelial barrier function in patients with ibs.

a single-blinded, randomised experimental study was conducted. potential participants were screened based on the inclusion and exclusion criteria during telephone interviews. as the patients were their own controls, self-reported allergy was not an exclusion criterion as long as both interventions were carried out during unchanged allergic exposure. patients were then randomly allocated to one of two study arms: referm® or thickened water (thick-it ®, commercially available; kent precision foods group, inc., muscatine, ia, usa) as placebo. the patients underwent sigmoidoscopy with biopsies obtained from the distal colon at baseline and after 14 days of intervention with referm® or placebo enema twice a day. the enema was administered rectally, in the left side position, and retained for as long as possible (at least 10 min) both in the left-sided and supine body position to activate retrograde peristalsis. to assess clinical improvement of symptoms, questionnaires were completed twice: before and after the intervention. during the 14 days of the intervention, the patients completed daily questionnaires. to improve compliance with the study intervention, the patients were given a check-up call by a principal investigator (obe) twice per week during the intervention period.

Eligibility criteria:
inclusion criteria: * confirmed ibs-d or ibs-m according to rome iv criteria * moderate to severe ibs according to ibs-sss score (≥175p) * age 18-70 years * fluency in written and spoken swedish language exclusion criteria: * organic gastrointestinal disease * previous major gastrointestinal operation (apart from appendectomy and cholecystectomy) * psychiatric disease (bipolar disease, schizophrenia) * nsaid intake less than 2 weeks prior to endoscopy * self-reported pregnancy
weekly versus 3-weekly docetaxel plus cisplatin for advanced nsclc

Conditions: Advanced Non-Small Cell Lung Cancer

Summary: to evaluate the toxicity and efficacy of docetaxel and cisplatin combination on two schedules in patients with previously untreated, advanced nsclc.

the combination of docetaxel 75 mg/m2 and cisplatin 60-80 mg/m2 administered every 3 weeks is one of the most commonly used chemotherapy regimen in korea for the first-line treatment of advanced nsclc. although the 3-weekly regimen is active and tolerated, it is associated with a significant incidence of severe neutropenia, often complicated by fever. therefore, there has been increasing interest in the use of a weekly administration of docetaxel as a way of reducing its hematologic toxicity. we designed this randomized phase ii trial to evaluate the safety profile and antitumor activity of two different schedules of docetaxel plus cisplatin given as first-line therapy in patients with advanced nsclc.

Eligibility criteria:
inclusion criteria: * histologically or cytologically proven non-small cell lung cancer * no prior chemotherapy or only adjuvant chemotherapy which had been completed \>6 months before registration * ecog performance status 0 to 2 * measurable lesion(s) * normal marrow, hepatic and renal functions * provision of written informed consent exclusion criteria: * active infection or severe comorbidities * history of anaphylaxis of any origin
non carbonic buffer power of critical ill patients with sepsis

Conditions: Acid-Base Imbalance; Respiratory Acidosis; Respiratory Alkalosis

Summary: alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment. the human organism is protected against acid-base disorders by several compensatory mechanisms that minimize ph variations in case of blood variations in carbon dioxide content. the aim of the present study is to quantify the buffer power, i.e. the capacity to limit ph variations in response to carbon dioxide changes, in critically ill septic patients and compare these results with data collected from healthy volunteers.

alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment. the human body is protected against acid-base disorders by several compensatory mechanisms that minimize ph variations in response to acid-base derangements. the present study focuses on the acute compensatory mechanisms of respiratory acid-base derangements, i.e., respiratory acidosis and respiratory alkalosis. in this case the non-carbonic buffers are constituted by albumin and phosphates in plasma, with the addition of hemoglobin in whole blood. aim of the present in-vitro study is to measure the buffer power of non-carbonic weak acids contained in whole blood and isolated plasma, assess the relative contribution of red blood cells and plasma proteins and perform a comparison between septic patients and healthy controls.

Eligibility criteria:
inclusion criteria: * septic patients and healthy volunteers exclusion criteria: * age \< 18 years and pregnancy

Keywords: acid-base equilibrium stewart's approach in vitro study respiratory acid-base derangements
proof-of-concept study to assess the efficacy and safety of srx246 in adults with ptsd

Conditions: PTSD

Summary: 18-week, crossover, double-blind, randomized, placebo controlled proof-of-concept study to assess the efficacy and safety of srx246 (160 mg bid) vs placebo in 52 adult veterans and civilians with a primary diagnosis of ptsd. subjects will be randomly assigned in a double-blind fashion to 2 groups in a crossover design. the first group will receive srx246 for 8 weeks followed by 8 weeks of placebo, while the second group will receive placebo for 8 weeks followed by 8 weeks of srx246. both groups will engage in a 7-day washout period between treatments. subjects will be assessed at baseline and then every 2 weeks during the trial using the caps.


Eligibility criteria:
inclusion criteria: * medically stable, current diagnosis of ptsd exclusion criteria: * medically unstable
retrospective study on clinical results of preimplantation genetic screening at different embryo stage

Conditions: Genetic Disorder; Fertility Disorders; Reproductive Disorder

Summary: preimplantational genetic screen (pgs) is tool for diagnosis of embryo chromosome abnormality before transfer. under this tool, patients with a family history of genetic disease or special genetic disease could avoid to produce chromosomal abnormalities of the next pregnant. this study is a retrospective study, data collection from 2001 jan. to 2015. nov. patients underwent pgs and data including the couples age, infertility factors, stimulation protocols, medicine records, embryo quality records and blood tests were collected in this study. analysis the relationship between outcomes of pgs, clinical outcomes and embryo quality is performed and further to find a diagnosis reference for clinical care.

research background preimplantational genetic screen (pgs) is tool for diagnosis of embryo chromosome abnormality before transfer. under this tool, patients with a family history of genetic disease or special genetic disease could avoid to produce chromosomal abnormalities of the next pregnant. for the preemergence of embryos before the genetic diagnosis must be carried out artificial reproductive treatment, the process includes induction of ovulation, ovulation, in vitro fertilization and embryo culture, to embryos grow to six to eight cells or cultured into the stage of blastocyst stage, under the embryonic section, take one or several cells, the slices of cells for genetic diagnosis, select the embryo without genetic disease implanted in the uterine cavity, in order to avoid the birth of genetic disease offspring. pgs can reduce the pregnancy when the chromosomal abnormalities of the fetus after implantation, but also to reduce the risk of abortion from chromosomal abnormalities, and can avoid the couples implanted with genetic abnormalities of the embryos, thereby significantly reducing it is important to promote the process of eugenics and reduce the social cost. research purposes the detection of chromosomal abnormalities of embryos are important factors for clinical diagnosis or screening before implantation. however, there is no complete analysis of domestic studies. this program will compare the genes or chromosomal abnormalities and clinical outcomes of embryo testing at different stages of embryonic development. research design this study is a retrospective study, data collection from 2001 jan. to 2015. nov. patients underwent pgs and data including the couples age, infertility factors, stimulation protocols, medicine records, embryo quality records and blood tests were collected in this study. analysis the relationship between outcomes of pgs, clinical outcomes and embryo quality is performed and further to find a diagnosis reference for clinical care.

Eligibility criteria:
inclusion criteria: * women underwent in vitro fertilization (ivf) treatment and preimplantational genetic screen (pgs). exclusion criteria: * n/a
the effects of local vibration and cervical stabilization exercises applied on neck muscles on balance in healthy individuals

Conditions: Cervical Pain; Somatosensory Disorders; Vestibular Diseases

Summary: in healthy individuals, many postural musculoskeletal problems arise due to various reasons. the cervical region is the region where these problems are most common. the cervical region ranks second in the general population after the lumbal area of musculoskeletal system disorders and affects close to 70% of the general population.the most important causes of this posture disorder are; muscular performance and strength are inadequate, as well as decreased proprioception of the muscles, deterioration of the individual balance systems that result in individual visual or vestibular problems. exercise therapy is at the forefront of these methods, while a variety of methods are applied in the prevention and treatment of neck problems. recent studies have focused on multifaceted treatments including exercises to improve strength, endurance and coordination of cervical muscles, proprioceptive training, relaxation exercises to prevent muscle tension, stabilization exercises and behavior modification. cervical stabilization exercises are a frequently used exercise approach. cervical stabilization exercises, which are different from ordinary exercises, are based on biomechanics, neurophysiology and physiotherapy research. the main objective of this method is; improve body awareness, maintain posture uniformity, improve strength, endurance, coordination and proprioception. stabilization exercises also increase the strength and endurance of the postural and stabilizer muscles, improving stability control in the stabilized and non-stabilized positions. another method that contributes to the development of balance and proprioceptive sense is vibration application. proprioception plays an important role in ensuring the coordination of movements. when the proprioception input is disturbed, both the position sense and the speed of movement may be affected. muscle-tendon vibration is a noninvasive method that is often used in proprioception studies. it has been suggested that the vibration application are the enhancing effect of the proprioceptive. however, there is not enough research on this subject. the purpose of this study is to determine whether the cervical stabilization exercises to be applied to the cervical region and the local vibration applied to the neck muscles are related to muscle performance, proprioception and balance and their superiority with each other.


Eligibility criteria:
inclusion criteria: * individuals who have not had neck pain in the last six months. exclusion criteria: * patients with atypical spinal cord anomalies, inflammatory or rheumatologic disorders, malignancy history, radiculopathy, myelopathy or other neurological disorders, vestibular disorders, and vertebral trauma history who underwent any surgical treatment for vertebral colonic at least 3 months before, was not included in the study.

Keywords: vibration cervical stabilization exercises physiotherapy and rehabilitation sensory organization test balance
treatment of gvhd in hematopoietic stem cell transplant (hsct) recipients using aat plus corticosteroids (cs) compared with corticosteroids alone (bmt ctn 1705)

Conditions: Graft Versus Host Disease (GVHD)

Summary: study csl964_5001 will investigate the efficacy of aat with corticosteroids compared with corticosteroids alone as first line therapy for patients with high-risk acute gvhd


Eligibility criteria:
inclusion criteria: * patients 12 years of age or older * initial presentation of acute gvhd after allogeneic hematopoietic cell transplantation for any indication * any graft or donor source or conditioning intensity * clinical diagnosis of acute gvhd requiring systemic therapy with corticosteroids exclusion criteria: * prior exogenous aat exposure for gvhd prophylaxis * relapsed, progressing, or persistent malignancy * de novo chronic gvhd or overlap syndrome developing before or present at the time of enrollment * receiving other drugs for the treatment of gvhd * receiving systemic cs for any indication within 7 days before the onset of acute gvhd