Kornimate/medical-research-clean huggingface dataset:
non invasive imaging methods for detecting pa：a clinical pet study of 18f-pentixather

Conditions: Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)

Summary: primary aldosteronism (pa) is the most common endocrine cause of hypertension. 68ga-pentixafor pet/ct possesses a relatively high sensitivity and specificity for aldosterone producing adenoma (apa) detection. however, 68ga is usually eluted from a 68ge-68ga generator, only a small amount of isotopes can be achieved once time. \[18f\]alf-chelation is a promising strategy that would solve these issues. 18f labeled pentixafor-based imaging agent(\[18f\]alf-nota-pentixather) has been reported by andreas poschenrieder. \[18f\]alf-nota-pentixather displayed high and cxcr4-specific in vivo uptake in daudi xenografts (13.9%±0.8% injected dose per gram \[id/g\] at 1 hour post injection\[p.i.\]). but to date 18f-pentixather has not been studied in humans. in this program the investigators will estimate the radiation dosimetry of \[18f\]alf-nota-pentixather, evaluate the sensitivity and specificity of the \[18f\]alf-nota-pentixather as a probe for apa.


Eligibility criteria:
inclusion criteria: 1. patients diagnosed with primary aldosteronism and willing to undergo surgery 2. clinically highly suspected of primary aldosteronism, but the diagnostic test cannot clearly identify the patients 3. postoperative recurrence in patients with primary aldosteronism exclusion criteria: 1. pregnant and lactating women. 2. patients with poor autonomous behavior ability, severe claustrophobia, and critically ill patients requiring life support who are unable to cooperate in completing the examination. 3. there are other situations where patients are not suitable for this examination

Keywords: primary aldosteronism radiation dosimetry 18f-pentixather
treatment of binge eating disorder in obesity: naltrexone/ bupropion combination versus placebo

Conditions: Binge Eating Disorder

Summary: this study will test the effectiveness of the combination of naltrexone and bupropion relative to placebo for reducing binge eating in persons with obesity and binge eating disorder.


Eligibility criteria:
inclusion criteria: * binge eating disorder (full criteria as described in the american psychiatric association diagnostic and statistical manual of mental disorders, 5th edition) * bmi between 30 kg/m2 and 50 kg/m2 * not taking anti-depressant medications * read english proficiently enough to read study assessments * available for duration of treatment plus follow-up period * able to travel to study location (new haven, ct) for monthly visits * agree to study procedures exclusion criteria: * medical status judged by study physician as contraindication * history of seizures * past or current anorexia nervosa, bulimia nervosa * current medications that influence eating/weight * current substance use disorder or other severe psychiatric disturbance (e.g., suicidality) that requires immediate treatment * pregnant or breastfeeding
infertile polycystic ovary syndrome (pcos) women with obesity and lifestyle changes

Conditions: Weight Loss

Summary: infertile pcos women with obesity were included into lifestyle change weight loss program prior to inclusion to ivf procedures. they attended group as well as individual workouts and they were advised on healthy eating.

the weight loss program will consist of dietary change and exercise program which will be performed 3 times weekly.

Eligibility criteria:
inclusion criteria: * bmi over 30 kg/m2 * pcos * primary or secondary infertility * normal partner's semen exclusion criteria: * other identifiable causes of infertility
infant-parent skin-to-skin contact during screening for retinopathy

Conditions: Retinopathy of Prematurity

Summary: retinopathy of prematurity (rop) is a feared complication of premature birth. if discovered in time, the disease can be treated, and impaired vision or blindness can be reduced. premature infants are therefore examined regularly after birth. however, the examination is painful and stressful for the infant. painful experiences might lead to a pathological stress response later in life and should therefore be prevented. in this study skin-to-skin contact with a parent is tested for relief of pain and stress in preterm infants being examined for retinopathy of prematurity.


Eligibility criteria:
inclusion criteria: * infants \< 32 weeks of gestational age (\< 31+6 weeks) exclusion criteria: * infants with ongoing analgesic treatment

Keywords: infant, premature pain stress, physiological stress, psychological skin-to-skin contact
postprandial liver and spleen stiffness measurements in the noninvasive diagnosis of cirrhosis

Conditions: Chronic Liver Disease

Summary: this is a study that will evaluate the utility of measuring liver and spleen stiffness before and after a meal by a non invasive ultrasound based technologies called fibroscan (transient elastography) and acoustic radio-frequency impulse (arfi) in diagnosing or excluding cirrhosis in patients with chronic liver disease who will be getting a liver biopsy.

this is a prospective longitudinal study that will evaluate the utility of change in liver stiffness (lsm) and spleen stiffness measurements after a test meal in patients whom the diagnosis cannot be reliably ruled in or ruled out based on two measurement of lsm by te per standard of care. this includes patients in whom there is discordance between clinical impression and lsm and/or lsm are in the grey zone (lsm between 10 and 15 kpa). liver biopsy/hvpg which is performed as standard of care will be used as gold standard.

Eligibility criteria:
inclusion criteria: * age 18-85 * history of chronic liver disease who have had a liver stiffness measurement performed that is discordant with clinical impression (clinically the patient appears to have cirrhosis but lsm \ 15) or lsm are in the grey zone (lsm between 10 and 15 kpa) exclusion criteria: * any signs of decompensated cirrhosis (e.g., jaundice, ascites, variceal hemorrhage, or hepatic encephalopathy) * hepatocellular carcinoma * patients with chronic hep c who have undergone antiviral therapy * ongoing alcohol abuse * acute hepatitis * pregnancy

Keywords: postprandial liver and spleen stiffness measurements transient elastography cirrhosis acoustic radiation force impulse
a study of ustekinumab to evaluate a "subject-tailored" maintenance dosing approach in subjects with moderate-to-severe plaque psoriasis

Conditions: Psoriasis

Summary: the purpose of the study is to assess the effect of extending maintenance dosing intervals beyond 12 weeks on the clinical efficacy and safety of ustekinumab in subjects with moderate-to-severe plaque psoriasis.

in this study, a proportion of subjects will receive study agent at its recommended dose and interval (45mg for subjects less than or equal to 100kg, or 90mg for subjects greater than 100kg; every 12 weeks after 2 starter doses at weeks 0 and 4). the majority of subjects will have the opportunity to receive study agent less frequently during the randomization period depending on the subject's response. the study consists of a 4-week screening period; a 28-week open-label run-in period; a double-blind treatment period from week 28 to week 104; a 12 week post-treatment period; and a 20-week safety follow-up. participants will be randomized for the double blind period into one of two study groups. group 1 participants will receive an injection of the study medication at a 12 week dosing interval. group 2 participants will undergo a placebo withdrawal and may receive study agents at an extended interval greater than 12 weeks. during the double-blind treatment period, subjects in groups 1 and 2 will receive placebo as necessary to maintain the blind.

Eligibility criteria:
key eligibility criteria * male or female * have had a diagnosis of plaque-type psoriasis at least 6 months prior to the first administration of study agent (subjects with concurrent psoriatic arthritis may be enrolled). * have plaque-type psoriasis covering at least 10% of their total bsa at screening and at the time of the first administration of study agent. * have a pga score of ≥ 3 at screening and at the time of the first administration of study agent.

Keywords: psoriasis ustekinumab stelara skin disease monoclonal
rox index versus mrox index to predict treatment outcome for high flow nasal cannula and/or noninvasive ventilation in patients with respiratory failure

Conditions: Respiratory Failure

Summary: one of managing steps in respiratory failure is high flow nasal cannula (hfnc), but the exact time to turn to invasive machine ventilation (imv) is necessarily being determined. respiratory rate and oxygenation (rox) index, defined as the ratio of oxygen saturation as measured by pulse oximetry (so2)/ fio2 to respiratory rate (rr), is used to determine when to intubate the patients who are on hfnc and prevent the delayed intubation. modified respiratory rate and oxygenation (mrox), defined as (pao2/ fio2) / respiratory rate, is also used to point the time of intubation in case hfnc of patients with respiratory failure . the diagnostic and prognostic accuracy of both parameters are reported in previous papers, but the preference of them is under research. in this study, we aim to observe and compare the diagnostic accuracy between rox and mrox in determine the time of invasive mechanical ventilation.

respiratory failure (rf) is a condition where there's insufficient oxygenation in the body tissue, whether acute, chronic or acute on chronic; occurring due to decreased oxygen or excessive carbon-dioxide in the blood . there are four types of respiratory failure; hypoxemic respiratory failure (type1), hypercapnic respiratory failure (type2), ) . causes of rf are varied and accounted for any abnormality related upper respiratory tract, lower respiratory tract, central and peripheral nervous system or muscles of respiration . however, in the last three decades, the most common causes of rf is acute myocardial infarction (ami), acute respiratory distress syndrome (ards), rf related to corona virus (covid-19) and acute exacerbation of chronic obstructive lung disease (copd).

Eligibility criteria:
inclusion criteria: * adult patients of both sex aged between 18 to 80 years * patient diagnosed with acute type 1or 2 or chronic type 1or 2 respiratory failure. * patient for chest icu admission * patient for hfnc and/ or noninvasive mechanical ventilation. exclusion criteria: * pediatric patients * pregnant females * patients who are for intubation on icu admissionc.

Keywords: rox index mrox index high flow nasal cannula noninvasive ventilation
prevention through activity in kindergarten trial

Conditions: Child, Preschool

Summary: objectives: the pakt project shall evaluate the effects of an exercise intervention in kindergarten combined with an educational training of parents and kindergarten teachers on behavior and health status of children. study design: baseline measurements were performed on more than 700 kindergarten children aged 43-67 months in may to july 2007. the kindergartens are located in and around wuerzburg in germany. kindergartens were then randomized in an intervention (21 kindergartens) and a control (20 kindergartens) group. the intervention group offers a daily exercise class lasting at least 30 min. parents and teachers of the children in the intervention program receive educational training. in addition, the children have activity homework involving the entire family. the control kindergartens keep their routine. follow-up measurements of physical activity (actigraph), motor skills, body mass index, skinfold thickness, and blood pressure take place in january/february 2008, june/july 2008, and september/october 2008. the number of accidents in and outside of the kindergartens and the number of children missing the kindergarten due to infections are monitored continuously. use of results: if the pakt program should proof effective, the results will be published in scientific journals and made public using the press. with the help of the gek, the program will then be implemented nationwide in kindergartens.


Eligibility criteria:
inclusion criteria: * children in participating kindergartens exclusion criteria: * health conditions restricting physical activity * age \ 67 months

Keywords: prevention physical activity obesity motor skills kindergarten
an open-label treatment protocol to provide continued elvucitabine treatment

Conditions: HIV Infections

Summary: extension study for participants currently participating in protocols ach443-015 and ach443-018.

human immunodeficiency virus (hiv)-1-infected, clinically stable, treatment-naïve adult participants who have completed 96 weeks of elvucitabine therapy and whose hiv ribonucleic acid (rna) levels remain below 50 copies/milliliter (ml) at the 92-week assessment in protocol ach443-015 or participants who have completed 48 weeks of elvucitabine therapy and continue to maintain an hiv-1 rna viral load below their baseline level upon entry into protocol ach443-018.

Eligibility criteria:
inclusion criteria: • participants must have successfully completed 96 weeks of elvucitabine therapy in protocol ach443-015 or participants have completed 48 weeks of elvucitabine therapy in protocol ach443-014a-018 . exclusion criteria: * participant has experienced virologic rebound as defined in section 5.6.1.3 of protocol ach443-015. * participant has exceeded their baseline hiv-1 rna level by week 44 as measured in protocol ach443-014a-018 * participant is experiencing a drug-related grade 3 or 4 rash or a drug-related grade 3 or 4 laboratory toxicity other than grade 3 or 4 cholesterol, triglyceride, creatinine kinase, or lactate dehydrogenase (ldh).

Keywords: extension study hiv-1 infection treatment naive
video game play to alleviate adolescent anxiety

Conditions: Anxiety; Anxiety Disorders and Symptoms

Summary: adolescence is a critical period for the onset and maintenance of anxiety disorders, which raises the importance of intervening early; one possibility of doing so is via digital interventions. at least two lines of research have been explored in the past years in this area. first, studies have tested the anxiolytic effects of casual video games, hypothesizing that, through the induction of flow, these games can effectively distract individuals from anxiety-related thoughts and feelings. second, the bidirectional link between poor attentional control and higher anxiety has led to the design of novel interventions aiming to improve attentional control such as working memory training studies. importantly, action video games, classified as a distinct gaming genre, have been shown to enhance attentional control. in this study, we aim to compare the effects of action video game play and casual game play to a no-training group, assessing their potential to alleviate anxiety when delivered entirely online. the goal of this three- arms randomized controlled trial is to evaluate the feasibility of a 6-week video game training intervention to reduce adolescent anxiety-related symptoms. we will also examine the efficacy of the proposed treatment when entirely deployed at adolescents' home.


Eligibility criteria:
inclusion criteria: 1. adolescents aged 11-15 years 2. high-anxious score from the 41 items scared-parent version (i.e. total score equal or above 17) 3. access to a computer (at least windows 7 or mac osx) at home and a reliable internet connection exclusion criteria: 1. dsm diagnoses of bipolar, psychosis, autism spectrum disorder, present or past. 2. neurological injury (i.e. head injury) 3. currently enrolled in another cognitive training intervention

Keywords: digital mental health video games cognitive training emotion regulation
automatic multimodal assessment of occurrence and intensity of pain for research and clinical use

Conditions: Rotator Cuff Injuries

Summary: 170 patients with rotator cuff syndrome will be filmed abducting and flexing their arms before learning a simple maneuver that alleviates most of the pain 90% of the time. they will then be filmed performing the same abduction and flexion of their arms. the patients will rate their pain on the common 10-point pain scale after abducting and flexing their arms before and after the maneuver.

facial expression and truncal metrics correlate strongly with occurrence and intensity of pain. rotator cuff syndrome almost invariably gives significant pain, especially with abduction and flexion of the arms. a simple maneuver that alleviates that pain 90% of the time, by activating the subscapularis to perform the function of the damaged supraspinatus muscle. this study strives to correlate facial and truncal characteristics with the ten-point pain scale by correlating the filmed changes in facial and truncal characteristics with the variations in patient-rated pain before and after the pain-controlling maneuver. once effective, the maneuver may be repeated for a number of days, after which time patients generally remain pain-free permanently.

Eligibility criteria:
inclusion criteria: rotator cuff syndrome - exclusion criteria: psychological or emotional instability other orthopedic conditions of the shoulders cosmetic facial surgery -

Keywords: tree number(s) c26.761.340 c26.803.063 c26.874.400 unique id d000070636
incidence of diarrhea using high and low osmolality enteral tube feeding in critically ill surgical patients

Conditions: Tube Feeding

Summary: the purpose and primary objective of this study is to determine if there is an association between enteral tube feed (tf) osmolality and diarrhea in critically ill patients. the investigators hypothesize that the administration of a tf formulation with high osmolality will cause more diarrhea than a tf formulation with a lower osmolality.


Eligibility criteria:
inclusion criteria: * age \>18 years * admitted to sicu or cvicu requiring tf for enteral nutrition * anticipated icu stay and tf requirement \>72 hours exclusion criteria: * contraindication to receiving one of the study tf formulations * inability to tolerate at least 75% of estimated requirement by day 3 of enteral tf administration * clostridium difficile infection or other cause of infectious diarrhea prior to study enrollment * presence of an ileostomy or colostomy * history of inflammatory bowel disease, bowel resection, short gut syndrome, or chronic diarrhea

Keywords: tube feeding diarrhea enteral nutrition critically ill surgical cardiovascular
cognitive behavioral treatment of posttraumatic stress disorder enhanced by virtual reality for individuals with ptsd and substance abuse

Conditions: Posttraumatic Stress Disorder; Substance Abuse

Summary: this study is exploring the use of an intervention designed to treat ptsd in individuals with comorbid ptsd and substance abuse resulting from the attacks of september 11 or from military service in iraq. a cognitive behavioral treatment protocol will be used to treat ptsd. the exposure component of the protocol will be enhanced with the use of virtual reality in which the client will view a virtual environment while describing their trauma.


Eligibility criteria:
inclusion criteria: * english-speaking * between the ages of 18 and 70 * exposed to the wtc attacks (were in towers or in the immediate area) or veterans of the iraq war * diagnosed with ptsd symptoms * current substance abuse disorder or history of substance abuse disorder exclusion criteria: * presence of current organic mental disorder * presence or history of schizophrenia, bipolar disorder or depression with psychotic features, delusional disorder * active suicidal ideation, intent, or plan * active homicidal ideation, intent, or plan * use of pacemaker * medically unstable * history of seizures

Keywords: ptsd substance abuse wtc attacks iraq war
dietary intervention replacing carbohydrate with protein and fat has greater effect on peripheral blood mononuclear cell metabolites than on plasma metabolites in patients with prediabetes or type-2 diabetes

Conditions: Prediabetes; Type-2 Diabetes

Summary: this study examined whether dietary-induced reductions in lipoprotein-associated phospholipase a2 (lp-pla2) activity in peripheral blood mononuclear cells (pbmc) and plasma affected metabolic profiles in pbmcs and plasma.

eighty nonobese patients (aged 40-70 years) with prediabetes or newly diagnosed type-2 diabetes were randomly assigned to a control group (normal diet with refined rice) or a whole-grain group (replacement of refined rice with whole-grains and legumes). this dietary intervention replaced approximately 7% of carbohydrate-derived energy with approximately 4% of protein-derived energy and approximately 3% of fat-derived energy.

Eligibility criteria:
inclusion criteria: * subjects who had ifg (100≤ fasting glucose \<126 mg/dl) * or newly diagnosed type-2 diabetes (fasting glucose ≥126 mg/dl) exclusion criteria: * current and/or past history of cardiovascular disease including angina * liver or kidney dysfunction * thyroid or pituitary disease * pregnancy or lactation * taking medications or supplements
safety & efficacy of sofosbuvir 400mg/ledipasvir 90mg in the treatment of chronic hepatitis c adolescents

Conditions: Hepatitis C Virus Infection, Response to Therapy of

Summary: randomized, open-label study in treatment naïve and treatment experienced, adolescence to determine the efficacy of sofosbuvir 400mg/ledipasvir 90mg in treatment naïve and treatment-experienced adolescence. hepatitis c virus (hcv) infection as measured by the proportion of subjects with sustained viral response 12 weeks after discontinuation of therapy (svr12)


Eligibility criteria:
inclusion criteria: 1. willing and able to provide written informed consent. 2. 12-18 years 3. hcv rna ≥ 104 iu/ml at screening. 4. confirmed chronic hcv infection as documented by either: a. a positive anti-hcv antibody test or positive hcv rna or positive hcv genotyping test at least 6 months prior to the baseline/day 1 visit, or 5. screening ecg without clinically significant abnormalities. 6. patients must have the following laboratory parameters at screening: * alt (alanine transaminase) ≤ 10 x the upper limit of normal (uln) * ast (aspartate aminotransferase) ≤ 10 x uln * hemoglobin ≥ 12 g/dl for male, ≥ 11 g/dl for female patients * platelets \> 50,000 cells/mm3 * inr (international normalized ratio) ≤ 1.5 x uln unless subject has known hemophilia or is stable on an anticoagulant regimen affecting inr * albumin ≥ 3 g/dl * hba1c ≤ 10% * creatinine clearance (clcr) ≥ 60 ml/min, as calculated by the cockcroft-gault equation 7. patient has not been treated with any investigational drug or device within 30 days of the screening visit. exclusion criteria: 1. chronic liver disease of a non-hcv etiology (eg, hemochromatosis, wilson's disease, α1 antitrypsin deficiency, cholangitis). 2. infection with hepatitis b virus (hbv) or human immunodeficiency virus (hiv). 3. history of solid organ transplantation. 4. current or prior history of clinical hepatic decompensation (eg, ascites, variceal hemorrhage, hepatic encephalopathy, hepatorenal syndrome and hepatopulmonary syndrome). 5. history of clinically-significant illness or any other major medical disorder that may interfere with subject treatment, assessment or compliance with the protocol. 6. history of a gastrointestinal disorder (or post-operative condition) that could interfere with the absorption of the study drug. 7. history of significant pulmonary disease, significant cardiac disease or porphyria. 8. history of difficulty with blood collection and/or poor venous access for the purposes of phlebotomy. 9. donation or loss of more than 400 ml blood within 2 months prior to baseline/day 1. 10. known hypersensitivity to the study investigational medicinal product, the metabolites, or formulation excipients.