Kornimate/medical-research-clean huggingface dataset:
ivi aflibercept before and after phaco in dme.

Conditions: Diabetic Macular Edema

Summary: to study whether or not cataract surgery should be deferred until treating the co-existing diabetic macular edema (dme) using intravitreal (ivi) anti-vascular endothelial growth factor (anti-vegf).

a prospective randomized interventional study included diabetic patients with visually significant cataract and dme. patients were divided into 2 groups. group a received three pre-operative intravitreal aflibercept injections with a monthly interval, the third injection was given intra-operatively. group b received a single intra-operative injection, and two post-operative injections with a monthly interval. follow up for 6 months.

Eligibility criteria:
inclusion criteria: - diabetic patients with visually significant cataract exclusion criteria: * previous vitreoretinal surgery * laser or intravitreal injections 6 months prior to the procedure * intractable glaucom * active intra-ocular inflammation * retinal detachment * vitreous hemorrhage * epi-retinal membranes * any other retinal vascular or neuroretinal disease. * patients with eventual cataract surgeries

Keywords: aflibercept; cataract; diabetic macular edema
interstitial lung disease registry construction

Conditions: Interstitial Lung Disease

Summary: the purpose of this study is investigating the clinical course, treatment course, and prognosis of patients with interstitial lung disease.

interstitial lung disease refers to pulmonary disease that occurs in the interstitium of the lung. it can be broadly classified into lung disease secondary to the cause of systemic disease or drug, and lung disease whose cause is unknown, and the latter is known as idiopathic interstitial pneumonia. idiopathic interstitial pneumonia is a lung disease showing various aspects of inflammatory response and fibrosis reaction, and the cause of the onset is not accurately known yet, also there is no effective treatment. idiopathic interstitial pneumonia, including idiopathic pulmonary fibrosis, progresses very slowly, but sometimes acute exacerbation without any obvious cause leads to death, rapidly. therefore, it is important to collect data prospectively for changes in clinical features, pulmonary function, imaging findings, and quality of life of these patients. a prospective study of idiopathic interstitial pneumonia will provide important information on the clinical characteristics and admission history of patients with idiopathic interstitial pneumonia, and the idiopathic interstitial pneumonia registry system will serve as the basis for further prospective observational studies. the aim of this study is to establish the registry of patients with interstitial lung disease and to prospectively review the clinical features and progression of the patients.

Eligibility criteria:
inclusion criteria: * patients older than 20 years diagnosed with interstitial lung disease * diagnostic criteria for interstitial lung disease. if one of the following is met: 1. clinical suspicion of idiopathic pulmonary fibrosis (ipf); characteristic chest ct findings with honeycomb cysts and fibrosis and reasonable clinical signs 2. suspected interstitial pneumonia, or confirmed by biopsy with no evidence of infection : ipf, non-specific interstitial pneumonia(nsip), cryptogenic organizing pneumonia(cop), unclassified fibrosis 3. interstitial lung disease suspects with underlying rheumatic disease exclusion criteria: * no specific criteria

Keywords: interstitial lung disease
response to rotavirus vaccine in infants in ho chi minh city in vietnam

Conditions: Rotavirus; Diarrhea

Summary: the primary objective is to measure the effect of host human genetics on the resulting immunological responses and long-term protection following rotavirus immunization of a study population of infants in ho chi minh city, vietnam. the secondary objectives are to assess the temporal immunological responses following rotavirus vaccination, and to investigate the role of maternally derived antibodies, and other factors that could potentially affect immunological responses following rotavirus vaccination. also to assess infecting rotavirus genotypes in the vaccine failure cases.

this study will be an open single arm, single centre, interventional study conducted in ho chi minh city, vietnam. a sample size of 1,000 infants will be recruited to the study between 8 to 9 weeks (which is around 2 months) of age. these infants will receive two doses of the rotavirus vaccine, rotarix with an interval of 28-37 days (or 4-5 weeks). the parents will be requested to bring the infants 2-3 days following each rotarix vaccination to receive the standard epi vaccinations. the infants will then be under passive and active surveillance for rotavirus-associated diarrhoea until 18 months of age. blood samplings during pre and post vaccination and at 6, 12 and 18 month old visits will be collected.

Eligibility criteria:
inclusion criteria: * infants (both males and females) between 8 and 9 weeks (i.e. approximately 2 months) of age who are attending hung vuong hospital to receive their standard epi vaccinations. * currently registered residents of districts 5 (where hung vuong hospital is located) or 1, 6, 8, 10, or 11 (districts that are neighbouring district 5) in ho chi minh city, with no specific intention of relocating in the next 12 months. * informed consent to be enrolled in the study and comply with study procedures, including host genetic studies. exclusion criteria: * refusal of consent. * parent/ guardian under the age of 18. * premature (i.e. gestation period \<37 weeks). * infants who have already been immunized with either a rotavirus vaccine or the standard 2-month epi vaccinations. * history of hypersensitivity to any components of the vaccine or adverse vaccine event. * history of intussusception or congenital malformation of the gastrointestinal tract in the child that is likely to predispose child to intussusception. * history of severe combined immunodeficiency disease (scid), acquired immune deficiency syndrome (aids) or human immunodeficiency virus (hiv) positivity, or other known immunodeficiency syndromes that may place the child at risk during immunisation.

Keywords: rotavirus vaccine diarrhea host genetics
knowledge attitudes, beliefs, and practices regarding hiv in populations living on the maroni river

Conditions: HIV

Summary: the hiv epidemic flared from 0 to over 1% prevalence in a decade on the maroni river which lies between french guiana and surinameaim of the study is to determine the knowledge, attitudes, behaviours, and practices on hiv in the population living along the french bank of the maroni border. descriptive statistics are computed from the tabulation of answers to a structured questionnaire. multivariate logistic models were computed to determine predictors of key outcomes. these data will help taylor prevention intervention in this very particular area.


Eligibility criteria:
inclusion criteria: * adult living on the maroni river exclusion criteria: * refusal to participate
exploring the long-term effects of cognitive exercise on cognition after stroke

Conditions: Chronic Phase Stroke Patients

Summary: this project will investigate the effectiveness of an intensive and focused working memory training program for chronic stroke patients. the investigators hypothesize that working memory training will be an effective method of improving working memory and related cognitive and behavioural functions in this population.

vascular cognitive impairment due to vascular disease and stroke frequently includes problems with attention, working memory and executive functions (e.g., monitoring, planning, and organization). these deficits are common - 32-73%, and chronic, and interfere with a patients response to rehabilitation, independence in activities of daily living, community re-integration, and overall quality of life after stroke. attention, memory and executive function impairments can adversely affect the ability to relearn various skills. cognitive impairments and their impacts on other components of functioning not only impact on the individual, but can also adversely affect the family via increases in caregiver distress and burden. thus, the presence of cognitive impairment has wide-reaching impact and deserves effective and consistent intervention similar to the attention devoted to improving function in physical domains. cognitive training can improve cognitive function, particularly in those areas known to involved in vascular cognitive impairment, i.e., attentional and executive function. accumulating evidence indicates that computer-based training can improve cognitive skills in healthy older adults as well as in clinical populations. attention and working memory training has also been shown to be effective in patients in the chronic phase post stroke. the investigators propose that specific cognitive training to improve working memory could provide direct benefit to chronic stroke patients. promising interventions focused on intensive and direct working memory training are emerging and have been shown to generalize to other cognitive domains, such as fluid intelligence.

Eligibility criteria:
inclusion criteria: * subjects must: (i) be ≥18 years of age, (ii) have been received the diagnosis of ischemic or hemorrhagic stroke \>6 months ago, (iii) be experiencing stroke-related cognitive problems that interfere with daily functioning, (iv) be able to perform a two-step command, (v) live within a 75 km radius of the queen elizabeth ii exclusion criteria: * subjects must not: (i) have moderate or severe receptive aphasia, (ii) have a terminal illness, life-threatening co-morbidity or concomitant neurological or psychiatric illness.

Keywords: chronic stroke near transfer far transfer working memory fluid intelligence cognitive training dual n-back
pain, inflammation, and cannabis in hiv

Conditions: HIV Infections; Neuropathic Pain; Cannabis

Summary: this study will examine how medical cannabis use affects neuropathic pain, inflammation and adverse events in people living with hiv (plwh) with neuropathic pain. we will study how varying ratios of thc and cbd in medical cannabis impact neuropathic pain, inflammation and adverse events.

this study will examine how medical cannabis use affects neuropathic pain in plwh with neuropathic pain. we will enroll adults with hiv who have a) neuropathic pain, b) are actively certified for medical cannabis, and c) intend to have soft gel capsule products dispensed at vireo (medical cannabis dispensary) (including a high thc:low cbd product, an equal thc:cbd product, and a low thc:high cbd product). over 14 weeks, data sources will include questionnaires, blood samples, urine samples; medical, pharmacy, and prescription monitoring program (pmp) records. the primary independent variable will be type of medical cannabis product dispensed at dispensary, and the primary outcome will be self-reported pain.

Eligibility criteria:
inclusion criteria: * \>= 18 years old * diagnosis of hiv * fluency in english * active certification for medical cannabis * no medical cannabis dispensed or used within the previous 30 days * intends to purchase soft-gel capsule medical cannabis at vireo * icd-10 diagnosis code for neuropathic pain, or * neuropathic pain in problem list of electronic medical record, or * neuropathic pain questionnaire-short form\>0 exclusion criteria: * inability to provide informed consent * inability to complete 14 weeks of study visits * medical cannabis use within 30 days prior to enrollment * unique pain symptoms (e.g. multiple sclerosis, rheumatoid arthritis) * terminal illness * current or prior psychotic disorder * street cannabis, opioid, cocaine, or benzodiazepine use in the past 30 days * dispensed opioids of benzodiazepines within 60 days * non-steroidal anti-inflammatory use within 7 days prior to enrollment * steroid use within the past 14 days with duration of therapy \>=21 days
molecular analysis of microbial dna in infected necrotizing pancreatitis

Conditions: Necrotizing Pancreatitis

Summary: necrotizing pancreatitis is a severe form of inflammation of the pancreas with subsequent destruction of the pancreas (necrosis). often, this condition manifests in patients as an overwhelming systemic inflammatory response and multisystem organ failure. many times the pancreas can become superinfected with bacteria and other organisms as a result of this process. clinicians may decide to sample fluid from the pancreas or pancreatic tissue to determine the presence of infection. this can be done through surgery with a concurrent debridement and drainage of the pancreas or by a radiologist using an ultrasound or ct guided method to sample the pancreatic fluid. these samples are then sent for culture in the microbiology laboratory. culture results often reveal 1-2 types of infecting bacteria that originate from the gastrointestinal tract. the investigators hypothesize that in actuality, many different kinds of bacteria may infect the pancreas. this project uses molecular dna techniques to help identify bacteria present in the pancreas of patients with severe necrotizing pancreatitis.

in this study, patients with severe necrotizing pancreatitis will be followed prospectively throughout their hospital course (anticipated duration of hospitalization ranging between 4-8 weeks). if patients are suspected to have infection of pancreatic necrosis, they will be consented for enrollment. patients will be determined by their attending physician to require either operative intervention or radiologic guided drainage of pancreatic necrosis and infected peripancreatic fluid. at the time of drainage procedure or intervention, one sample of peripancreatic fluid will be sent to the hospital's microbiology department for standard gram stain and bacterial culture identification and a second sample will be frozen for bacterial dna analysis. patients will be followed for the duration of their hospitalization for in hospital outcomes, mortality and final microbiology culture results. samples will then be processed at six months and one year following sample collection for bacterial dna deep sequencing analysis and will be compared to bacteria identified using standard culture technique.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * severe necrotizing pancreatitis as evidenced by clinical examination, biochemical analysis, and/or imaging studies demonstrating pancreatitis and pancreatic necrosis exclusion criteria: * age less than 18 years old * participation in another device or drug study

Keywords: necrotizing pancreatitis pancreatitis infection bacteria microbiology
intensive therapy of shoulder external rotators in erb's palsy

Conditions: Erbs Palsy

Summary: erb's palsy is a common neurological injury occurs at the time of birth. it causes injury to the upper trunk nerve root c5-c6, i.e., supply is around shoulder and muscles of forearm and these nerves network from the spine and pass through the cervicoaxillary canal in the neck and the ribs and emerge into the axilla. restoring external rotation in erb's palsy is quite difficult and mostly surgery is recommended but if physiotherapy sessions are given with extended time up to 2 hours and latest techniques are applied to strengthen external rotators then range of external rotation can be improved.

erb's palsy is form of brachial plexus palsy which involves injury to cervical nerve roots c5 c6 causing loss of movements and deformities i.e., internally rotated shoulder, hanging arm and waiter's tip hand deformity. most common risk factors are shoulder dystocia, maternal obesity, breech presentation and high birth weight of child. its incidence is 0.42 per 1000 live births in which 25% experience permanent impairment and injury. both conservative and non-conservative treatment protocols are applied in erb's palsy but key interventions are positioning in early infancy, passive range of motions and gentle stretching. another latest treatment approach is intensive physical therapy in which single session duration is extended to three to four hours with combination of treatments. this study will be randomized control trial, used to check effectiveness of intensive physical therapy to restore shoulder external rotation in erb's palsy. subjects with erb's palsy meeting the predetermined inclusion and exclusion criteria will be divided into two groups by using lottery method. pre assessment will be done by using arom on goniometer as objective measurement. subject in one group will be treated with intensive physical therapy and the other with conventional treatment. each subject will receive 5 treatment sessions per week for 6 months. recorded values will be analyzed by using spss version 25

Eligibility criteria:
inclusion criteria: * children (male and female) * ages ranged from 9 months to 12 months * unilateral involvement of c5, c6 and c7 * patients did not undergo surgery of the nerves or plexus exclusion criteria: * musculoskeletal or neuro-muscular abnormalities other than erb's palsy * contractures or fixed limitations in the affected upper extremity * hypersensitivity to latex and adhesive tapes

Keywords: external rotation, intensive session, c5-c6
phase ii dose-ranging study in subjects with mild to moderate ulcerative colitis treated with spd476

Conditions: Colitis, Ulcerative

Summary: evaluate the percentage of subjects in remission at the end of an 8-week treatment period for three dose groups (spd476 1.2 g/day, 2.4 g/day or 4.8 g/day, administered once daily).


Eligibility criteria:
inclusion criteria: * male \& female subjects greater than or equal to 18 years of age with newly diagnosed or relapsing mild to moderate ulcerative colitis * general medical assessment satisfactory and no clinically significant and relevant abnormalities exclusion criteria: * severe ulcerative colitis * subject in relapse for \> 6 weeks * use of systemic or rectal steroids within last 4 weeks prior to baseline * subjects with proctitis, previous colonic surgery, crohn's disease, bleeding disorders, active ulcer disease * subjects hypersensitive to salicylates/aspirin * subjects with moderate or severe renal impairment
novel treatment for patients with peanut allergy: intralymphatic immunotherapy

Conditions: Food Allergy Peanut

Summary: use of three intralymphatic injections of peanut allergen one month apart to induce tolerance to peanut in peanut allergic people.

eligible subject undergo a baseline blinded oral peanut challenge. then the peanut ilit as described above. pretreatment with antihistamines, leukotriene modifier and albuterol before each treatment. following the three ilit peanut injections a repeat blinded oral peanut challenge is performed. blood is drawn at each of the 5 study visits for a variety of tests trying to elucidate the mechanism(s) of the induction of tolerance to peanut.

Eligibility criteria:
inclusion criteria: history of peanut allergy positive prick skin tests or invitro ige to peanut positive blinded oral peanut challenge. - exclusion criteria: history of * life threatening anaphylaxis to peanut uncontrolled asthma
extension for community healthcare outcomes autism replication evaluation

Conditions: Autism Spectrum Disorder

Summary: echo autism was intended to assess rigorously the impact of a 12-session telemedicine training program on participating primary care providers (pcp) knowledge, clinical behavior, and self-efficacy in the screening and care of children with autism spectrum disorder (asd). each session is referred to as an "echo clinic".

the study involved 10 sites (each referred to as an "echo autism hub"), each running a 12-session training program using a common curriculum and core lecture, with each site expected to recruit 15 pcps. sites were randomized in a stepped-wedge design with 5 clusters (2 sites per cluster) and a staggered start over a 1-year period. staggering the start allowed for some control for potential temporal trends, as well as allowing the core team to focus on working with each site to ensure smooth startup of the training program at each site. outcomes are measured at baseline (month 0), during the intervention (approximately 3 months after the start of the intervention) and after the end of the intervention (approximately 6 months after the start of the intervention). an additional measurement was made 3 months after the end of the intervention to assess whether deterioration occurs after clinic participation ends. all participants received the intervention.

Eligibility criteria:
inclusion criteria: * current practice as a primary care provider (pcp) * currently providing care for children * professional training in: general pediatrics, family medicine, advance practice nursing (i.e. nurse practitioner or physician assistant) * active medical license in the state of practice * patient population is at least 50% underserved exclusion criteria: * trainee status (e.g., medical student, intern, resident, or other pre-professional trainee) * subspecialist (e.g., psychiatrists, neurologists, developmental and behavioral pediatricians) * practicing within the same practice as another pcp participant (i.e., only one pcp participant from any given practice may be enrolled as a research participant in the study)

Keywords: asd autism telehealth primary care providers
evolving routine standards in intracoronary physiology

Conditions: Myocardial Ischemia

Summary: italy is the european country with the minor penetration of ffr as compared to the number of percutaneous coronary intervention. accordingly, the società italiana di cardiologia invasiva (sici-gise) conceived and promoted a prospective nationwide study to describe the patterns of the use of ffr in an unselected real-world population and to to assess the reasons, on clinical decision making, driving operators in the use or not of the ffr.

fractional flow reserve (ffr) has been validated as a reliable surrogate for inducible ischemia, supporting its use during invasive procedures for functional assessment of coronary lesions. landmark randomized trials have demonstrated that deferral of nonsignificant lesions based on ffr is not only safe, but also that ffr-guided revascularization is associated with a better clinical outcome up to 2 years, when compared with standard angiography. in spite of the overwhelming evidence of its potential clinical and economic benefits and strong guideline recommendation, the adoption of ffr in the real-world is perceived to vary significantly. reasons for this disparity are several, but most operators still do rely the most on angiographic eye-balling to decide on the functional significance of coronary lesions and the need for revascularization. italy is the european country with the minor penetration of ffr as compared to the number of percutaneous coronary intervention. accordingly, the società italiana di cardiologia invasiva (sici-gise) conceived and promoted a prospective nationwide study to describe the patterns of the use of ffr in an unselected real-world population and to to assess the reasons, on clinical decision making, driving operators in the use or not of the ffr.

Eligibility criteria:
inclusion criteria: fractional flow reserve performed group * age \>18 years * written consent * assessment with ffr of at least one coronary lesion fractional flow reserve not performed group * age \>18 years * written consent * absence of assessment with ffr of at least one coronary lesion + at least one of the following criteria 1. stable coronary artery disease, absence of non-invasive stress test, evidence of coronary lesions between 50%-90% (visual estimation or quantitative coronary analysis) 2. stable coronary artery disease, presence of non-invasive stress test, evidence of coronary lesions between 50%-70% (visual estimation or quantitative coronary analysis) 3. acute coronary syndrome, culprit lesion not identifiable or coronary lesions different from the culprit between 50%-70% (visual estimation or quantitative coronary analysis) exclusion criteria: * written consent denied