Kornimate/medical-research-clean huggingface dataset:
feasibility in the prophylaxis of radiation dermatitis severity

Conditions: Radiation Dermatitis

Summary: to compare radiation dermatitis severity in irradiated skin protected by an agent verses uncovered skin based on photographs and track patient reported outcomes with use of the agent.


Eligibility criteria:
inclusion criteria: * age ≥ 18years * undergoing external beam radiotherapy for head/neck cancer at mayo clinic rochester campus. note: patients undergoing concurrent chemotherapy are eligible. * able to provide informed written consent * willing to consent for photography of radiation field * receiving a dose ≥ 45 gy and 20 fractions to both the area being treated and the area being used for comparison exclusion criteria: * patients with active rash, pre-existing dermatitis, lupus, tattoos, scleroderma or other conditions within the treatment area that may make skin assessment for the study difficult per treating physician discretion. * patients with known allergic and other systemic skin diseases even if not directly affecting irradiated fields. * any medical condition that in the opinion of the investigator should exclude him/her from participating in the study. * enrolled in an investigational study where product was applied to the proposed study site within 30 days of the screening visit * the skin area affected by radiation requires treatment with a concomitant medication or product (if applicable)
patient-posture and ileal-intubation during colonoscopy

Conditions: Colonoscopy

Summary: during colonoscopy, the colonoscopist employs various maneuvers, including changing the patient's posture to left-lateral decubitus or supine, to achieve complete colonoscopic examination. posture change has also been reported to increase the success rate of ileal intubation. however, there has been no randomized trial which has shown that a particular posture of the patient increases the success rate of ileoscopy. the present study will be carried out to determine the impact of the patient's posture (left lateral vs supine position) on success rate of ileal intubation.


Eligibility criteria:
inclusion criteria: * all adult (\> 12y old) patients referred for colonoscopy exclusion criteria: * acute fulminant colitis * acute intestinal obstruction * suspected intestinal perforation * peritonitis * pregnancy * severe cardio-respiratory disease (asa grade...) * decompensated liver disease * recent pelvic or colonic surgery (in last 6 months) * large aortic or ileac artery aneurysm * human immunodeficiency virus infection * uncooperative patients

Keywords: tuberculosis ibd endoscopy
study of prophylactic vs preemptive valganciclovir

Conditions: Cytomegalovirus Infection

Summary: this is a study of prophylactic vs preemptive oral valganciclovir for management of cytomegalovirus infection in adult renal transplant recipients looking at clinical and pharmacoeconomic outcomes

this is a study of prophylactic vs preemptive oral valganciclovir for management of cytomegalovirus infection in adult renal transplant recipients looking at clinical and pharmacoeconomic outcomes. patients at risk for cmv (d+/r-, d+/r+, d-/r+) were randomized to prophylaxis (valganciclovir 900 mg qd for 100 days, n=49) or preemptive therapy (900 mg bid for 21 days, n=49) for cmv dnaemia (cmv dna level \>2000 copies/ml in ≥ 1 whole blood specimens by quantitative pcr done weekly for 16 weeks then at months 5, 6, 9, and 12. clinical and virologic outcomes were measured and pharmacoeconomic outcomes will be analyzed

Eligibility criteria:
inclusion criteria: * all patients who received a kidney transplant at washington university medical center between march 2003 and june 2004. exclusion criteria: * age younger than 18 * refusal to consent for the study * allergy to ganciclovir and severe illness too serious to justify randomization

Keywords: cytomegalovirus kidney transplantation valganciclovir preemptive
an assessment of the glider balloon in complex lesions

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to collect data from real-world use with the glider percutaneous transluminal coronary angioplasty (ptca) balloon catheter to support the effectiveness of the glider ptca balloon for crossing into complex coronary lesions.

observational study collecting data on commercial cases in which the glider ptca balloon catheter is used in accordance with the instructions for use. this study includes up 500 patients at up to 50 study sites.

Eligibility criteria:
inclusion criteria: 1. lesion must be successfully crossed with a guidewire without complication (including chronic total occlusions (ctos)) 2. the glider balloon may only be used at one lesion during the procedure 3. the lesion in which the glider balloon is used must be completed first 4. the primary lesion treated during the procedure must be treated with the glider balloon 5. intended treatment of a protocol-defined complex lesion that has at least one of the following factors: * significant vessel tortuosity * failed balloon crossing with another balloon * tight stenosis * heavy calcification * side branch present exclusion criteria: 1. patient \< 18 years of age 2. lesion longer than 40mm 3. device use not consistent with instructions for use 4. patient has not given consent for their data to be submitted to this registry
the effect of processing on food reward

Conditions: Metabolic Diseases

Summary: the minimally processed diets of our ancestors have been rapidly replaced by upfs driving poor diet to become the leading risk factor for preventable death globally. hence, it is essential to understand what properties of upf are driving their overconsumption to reduce diet-related mortality. to address this gap in knowledge this proposal will test: * if upfs have a greater post meal metabolic response when compared to mpfs an essential signal for food reward * through the use of an auction task paradigm if upfs overvalued and if this value is differentially encoded in the brain this study is a fully cross-over design in that each participant receives all conditions and therefore serves as their own control. all orders of foods will be counterbalanced. although participants cannot be blinded to the conditions as they must be aware of the foods they are eating, they will not be made aware that the key manipulation is food processing. on different days participants will come to the lab and consume a meal containing either minimally or ultra-processed foods as determined by the widely used nova (not an acronym) scale. these conditions will be consumed in a whole room metabolic chamber allowing for simultaneous measurement of multiple metabolic responses (glucose, insulin, and metabolic rate). these measures will be collected for 45 min before consumption of the meal (baseline) and for 3 hours after consumption (post-prandial). all participants will also undergo a becker-degroot-marschak auction paradigm that consists of foods that are either minimally or ultra-processed in the mri scanner. food value will be measure in participants' willingness to pay for each food and neural responses will be measured during presentation of the food cues.


Eligibility criteria:
inclusion criteria: * bmi between 18.5-24.9 kg/m2 * not pregnant or planning to become pregnant during study participation residing in the roanoke area and/or willing/able to attend sessions at the fralin biomedical research institute * able to speak and write in english * participants must be able to see a computer display clearly with or without vision correction (eyeglasses, contacts). exclusion criteria: * claustrophobia (this would make lying in an mri scanner or indirect calorimetry canopy very uncomfortable). 2. history of head injury resulting in loss of consciousness for more than 10 minutes 3. current or past diagnosis of diabetes or metabolic disorder (thyroid disease, etc.) 4. contraindications to mri: individuals with pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. 5. history of alcohol or drug dependence 6. active neurologic disorder 8. diagnosed eating disorder 9. food allergies or restrictive diet
the men are now united program

Conditions: Type2 Diabetes

Summary: the purpose of this application is to create and implement a targeted, culturally grounded, diabetes self-management intervention for black men that uses social support, mobile health, and remote sensing technology to improve diabetes-related outcomes.

the investigators propose a single-subject, repeated measures intervention where each participant will serve their own control. participants will serve as their own controls for a period of three months prior to the start of the four-month intervention. the study will conclude with an assessment 7-months from baseline. single-subject designs are most often used in applied research. the design allows the participant to serve as the control, rather than using another individual/group. the design is sensitive to individual differences whereas group designs are sensitive to averages of groups. year 1 is dedicated to the development of the text messages and the content for the 10 group meeting sessions. year 2 focuses on the time-1 control period assessment (pre-baseline at 3 months before the intervention), the time-2 assessment (baseline), implementation of the 10-week intervention, a post-intervention assessment (time-3), and 3-month follow up at time-4, and analysis. specifically, in year 2, the primary outcome of a1c will be assessed at time-1, 3 months later at the start of the intervention, at the end of the intervention, and at 7-months. the investigators will also include secondary assessments of glucose readings, waist circumference, and blood pressure.

Eligibility criteria:
inclusion criteria: * black/african american * male * tyep 2 diabetes * 21 years old or older * owns cell or smart (mobile) phone or willing to use one if provided exclusion criteria: * non-ambulatory * serious physical illness * psychiatric diagnosis of serious mental illness * serious diabetes complications impeding meaningful participation

Keywords: gender men black/african american self-management
study of the imaging agent 18f-var3 in patients with breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to measure the safety of the investigational imaging agent, 18f-var3 and to determine if it is helpful in providing information about how tumor tissues behave.


Eligibility criteria:
inclusion criteria: * age 18 years or greater * biopsy-proven breast malignancy * \>/= 1 viable lesion, \>/= 1 cm, confirmed on ct, mr, or fdg pet/ct within 4 weeks of protocol enrollment * newly diagnosed or recurrent disease, on or off therapy * ecog performance of 0-2 \*note: lesions are considered viable if they are stable or increasing soft tissue lesions, or if they are fdg-avid bone lesions exclusion criteria: * life expectancy \< 3 months * pregnancy or lactation * biopsy or other surgical procedures within 48 hours prior to receiving study intervention * patients who cannot undergo pt/ct scanning because of weight limits. pet/ct scanners may not be able to function with patients over 400 pounds

Keywords: breast cancer 18f-var3 first in human acidosis imaging memorial sloan kettering cancer center 19-147
cutaneous remote ischemic preconditioning in plastic surgery

Conditions: Ischemic Preconditioning

Summary: background: in plastic and reconstructive surgery, free flaps are routinely used for treatment of soft tissue defects. treatment strategies aim at reducing or preventing flap necrosis by conditioning tissue tolerance against ischemia. although previous studies indicate that remote ischemic preconditioning (ripc) is a systemic phenomenon, only a few studies have focused on the elucidation of its mechanisms of action. therefore, the aim of this study is to evaluate the microcirculatory effects of remote ischemic preconditioning on a potential free flap location in a human in-vivo setting for the first time. conclusion: remote ischemic preconditioning improves cutaneous tissue oxygen saturation, arterial capillary blood flow and postcapillary venous flow in a remote free flap donor location. to what extent remote preconditioning might ameliorate the reperfusion injury of free flap transplantation, further clinical trials have to evaluate both in the means of microcirculatory assessment and partial or total flap loss as end points of these studies.


Eligibility criteria:
inclusion criteria: * healthy male and female subjects aged 18 to 35 years exclusion criteria: * soft tissue inflammation or osteomyelitis, peripheral arterial occlusive disease, vasculitis, chronic kidney or liver disease, cardiac dysfunction, arterial hypotension and any type of vasoactive medication, i.e. ß-blockers, calcium channel blockers, nitroglycerin

Keywords: remote ischemic preconditioning, free flap, microcirculation
alcohol use and relationships - iii

Conditions: Intimate Partner Violence; Substance Use

Summary: the investigators hypothesize that individuals receiving the brief substance use intervention will have better substance use and intimate partner violence outcomes than individuals receiving the general health improvement intervention. all participants receive standard batterer intervention.


Eligibility criteria:
inclusion criteria: * participation in batterer intervention program in ri * hazardous drinking exclusion criteria: * drinks too much
usefulness of the cadiss® system for the cleavage of severe adhesions in cholecystectomy

Conditions: Cholecystitis, Acute

Summary: acute cholecystitis is the most common complication of cholelithiasis. acute cholecystitis is inflammation of the gallbladder that develops over hours, usually due to an obstruction of the cystic duct by a gallstone. removal of the gallbladder (cholecystectomy) is the only definitive treatment for acute cholecystitis, with laparoscopic cholecystectomy (lc) considered the gold standard. serious complications that may occur with laparoscopic cholecystectomy, including bile duct injury, bile leaks, bleeding, and bowel injury, result in part from the anatomy, disease related pathology and structural misidentification due to inflammatory process (gupta 2019). the cadiss® system, chemically assisted mechanical dissection, is intended for the selective detachment of pathological tissue layers and/or fibrotic tissues in various surgical procedures without using cutting instruments. it is based on the property of the drug mesna (sodium 2-mercaptoethane sulfonate) to cleave the disulfide bonds responsible for the adherence of pathological tissues and for the strength of fibrosis. this study is a prospective, multi-sites, open label, single cohort clinical trial evaluating the use of cadiss® system to facilitate dissection of severe adhesions in cholecystectomy and to allow better identification of different structure.


Eligibility criteria:
inclusion criteria: * ≥ 18 years old * weight \> 30 kg * confirmed diagnosis of acute gallstone cholecystitis * symptomatic or asymptomatic cholecystitis * under surgery for cholecystectomy: * for the 5 first patients : cholecystectomy will take place within 72 hours of the first symptoms of cholecystitis * after the 5 first patients : cholecystectomy will be allowed at any time after the first symptoms and at physician judgment * patient agrees to signed the informed consent exclusion criteria: * \< 18 years old * ≤ 30 kg * known hypersensibility to mesna * patient taking anticoagulant at the screening visit * patient having a pancreatitis or angiocholitis * patients suffering from hepatic or renal disorders * unable to sign the informed consent * participation in any study involving an investigational drug or device within the past 3 months. * patient is pregnant, breastfeeding or has wish of pregnancy during the study. * individuals under tutorship or trusteeship
effect on quality of life of adapted information in pulmonary rehabilitation in chronic respiratory disease patients

Conditions: Chronic Respiratory Disease

Summary: the purpose of the clinical study is to study the effect of health-related quality of life of information aimed at reducing the impact of a personality trait (openness to experiences) identified as a risk of non-response to pulmonary rehabilitation in patients with chronic respiratory diseases. this study will determine if a specific information focusing on characteristics of openness to experiences personality trait will lead to better benefits than a general information.

according to the five factor model, personality is made of five dimensions present in varying degrees in individuals and influencing their behavior and life experiences. several studies showed that some personality traits, according to their level, may positively or negatively influence the quality of life. they can also have an impact on the benefits obtained at the end of one treatment. in the particular context of pulmonary rehabilitation (pr) which is one of the most efficient treatment in respiratory diseases, it has been showed that with a classical support, higher scores for openness to experiences represent a risk factor for non-response in pr on quality of life (i.e. no improvement). several authors showed that adapted interventions (ex: simple information booklets), based on personality traits, can enhance the effectiveness of the intervention. considering that in chronic respiratory diseases, openness to experiences when it is more marked represents a risk of not improving the quality of life following a pr program, the idea of offering information in line with the characteristics of these people (i.e., search for novelties, autonomy, broad and varied interests, etc.) seems relevant and feasible. the investigators hypothesize that the patients receiving an adapted information aimed at reducing the impact of a personality trait (openness to experiences) will better improve their quality of life in comparison with the patients receiving a neutra information. the main objective is to assess the impact of life of an adapted information during pulmonary rehabilitation on quality in patients with chronic respiratory diseases.

Eligibility criteria:
inclusion criteria: admitted for a 4-week inpatient pulmonary rehabilitation program chronic respiratory disease diagnosis 18 and 80 years old reading and writing skills oral consent exclusion criteria: inability to participate to exercise training inability to answer a questionnaire severe or unstable heart disease, orthopedic, neurologic or psychiatric comorbidities recent exacerbation (\<4 weeks) pregnant and breastfeeding women protected adults, pregnant women participation in another study, with the exception of observational studies

Keywords: pulmonary rehabilitation personality traits adapted information
oral manifestation in patients with sars-cov2 infection.

Conditions: SARS-CoV Infection

Summary: the oral cavity is particularly susceptible to viral infection with several viruses such as herpes simplex virus, cytomegalovirus and zika virus because of its structures, especially salivary glands and soft tissues moreover, oral mucosa can be affected by secondary pathological process of a bacterial or fungal nature due to viral immunosuppression. the oral cavity could be considered a "biological barometer" of both viral infection and viral immunosuppression advancement .

the sars-cov2 virus was identified in china at the end of 2019 and spread worldwide causing a global pandemic. current research showed that sars-cov2 virus invades human cells via the receptor angiotensin-converting enzyme 2 (ace2) through scrna-seq data analyses. the study identified the organs that are at risk and are vulnerable to sars-cov-2 infection. therefore, cells with ace2 receptor distribution may become host cells for the virus and cause inflammatory response in related organs and tissues, such as the tongue mucosa and salivary glands. these results suggest that oral mucosa could be a target of sars-cov-2 infection . although many authors reported the presence of oral lesion associated with sars-cov2 infection, the prevalence of the oral manifestation and the range of oral manifestation are still unknown. further studies are necessary to better understanding of the symptoms of the sars-cov2 virus in order to faster detection. a multidisciplinary team following the patients could be the key in treatment of the infection and faster recovery.

Eligibility criteria:
inclusion criteria: * a diagnosis of sars-cov2 with pcr. * age range from 18-60 years old exclusion criteria: * pregnancy or contraceptive pills * lactation * any auto-immune disease that could affect the oral mucosa * on any neoplastic therapy. * uncontrolled diabetes

Keywords: oral manifestation sars-cov2 prevelance
a prospective multicenter randomized controlled trial of flexible and navigable suction ureteral access sheath combined with needle perc for the treatment of partial staghorn renal calculi

Conditions: Urinary Calculi

Summary: the goal of this clinical trial is to learn if flexible and navigable suction ureteral access sheath combined with needle perc works to treat partial staghorn renal calculi. it will also learn about the safety of drug abc. the main questions it aims to answer are: * does flexible and navigable suction ureteral access sheath combined with needle perc result in similar stone free rate compared with pcnl * does flexible and navigable suction ureteral access sheath combined with needle perc result in more complications compared with pcnl researchers will compare flexible and navigable suction ureteral access sheath combined with needle perc result in similar stone free rate compared with pcnl to see if flexible and navigable suction ureteral access sheath combined with needle perc works to treat partial staghorn renal calculi. participants will: * performed flexible and navigable suction ureteral access sheath combined with needle perc or pcnl * visit the clinic after surgery 1 month and 3 month for checkups and tests


Eligibility criteria:
inclusion criteria: 1. aged 18-80 years 2. ct scan indicates partial staghorn calculi 3. able to complete the study in accordance with the protocol requirements 4. informed about the study and has signed the informed consent form exclusion criteria: 1. severe renal insufficiency (gfr \< 30 ml/min/1.73 m²) 2. significant calyceal hydronephrosis (calyceal width ≥ 2 cm) 3. renal stone volume \> 33.5 cm³ 4. renal stones or nephrocalcinosis caused by genetic diseases or definite metabolic disorders that have not been ruled out, such as renal tubular acidosis, primary hyperoxaluria, primary hyperparathyroidism, etc. 5. congenital or structural renal abnormalities: spinal deformity, ankylosing spondylitis, horseshoe kidney, medullary sponge kidney, duplicated kidney, polycystic kidney, ectopic kidney, etc. 6. history of previous open renal stone surgery 7. patients with uncontrolled urinary tract infections 8. subjects deemed by the investigator to have other factors that make them unsuitable for participation in this trial

Keywords: partial staghorn renal calculi