Kornimate/medical-research-clean huggingface dataset:
dietetic and hygiene measures in metabolic neuropathies: the neurodiet study

Conditions: Peripheral Nervous System Diseases; Diabetic Polyneuropathy; Metabolic Syndrome X

Summary: metabolic disorders such as diabetes mellitus, glucose intolerance and possibly metabolic syndrome can induce a peripheral neuropathy. to investigate the effect of physical training and diet education on neuropathic symptoms and neurophysiological parameters of patients with metabolic neuropathies.

metabolic disorder such as diabetes mellitus, glucose intolerance and possibly metabolic syndrome can induce a peripheral neuropathy. the objectives of the present study are to investigate: 1. the effect of physical training and diet education on neuropathic symptoms and neurophysiological parameters 2. the best coaching modality of education. this will be a prospective single blind study (blinded evaluator). patients will be randomly assigned in two groups. the first group will have a one-day therapeutic education program followed by a 5-minutes phone call every week for 3 months. the second group will have the same one-day therapeutic education program that will be followed by an unique one-hour phone call. during the one-day therapeutic education program and the phone calls, hygienic rules (ie physical activities) and dietetic regimen advices will be given to patients. evaluation will be done at 3 months.

Eligibility criteria:
inclusion criteria: * clinical and neurophysiologic neuropathy (clinical signs of neuropathy and at least two low sensory nerve action potential (superficial peroneal and sural nerves)) * metabolic disorder: glucose disorder (diabetes mellitus or glucose intolerance) or metabolic syndrome * clinical signs for less than 2 years * no therapeutic modification in the last 3 months * possibility to delay any drug modification during 3 months exclusion criteria: * non metabolic neuropathy * serious diabetic complication * renal failure (creatinine clearance\<60ml/min) * sensory neuronopathy * contra-indication to physical activity * type 1 diabetes mellitus * no written consent

Keywords: peripheral nervous system diseases diabetic polyneuropathy metabolic syndrome x
investigation of impairments in body functions and structures, activities and participation restrictions in copd

Conditions: Chronic Obstructive Pulmonary Disease; Balance; Activity, Motor; Participation, Patient

Summary: this cross-sectional study aims to investigate to the impairments in body functions and structures, activities and participation restrictions according to the international classification of functioning, disability and health (icf) framework in chronic obstructive pulmonary diseases (copd) patients.

to investigate the impairments in body functions and structures, activities and participation restrictions according to the international classification of functioning, disability and health (icf) framework in patients with copd, fifty patients with copd will be included. the modified medical research council dyspnea (mmrc) scale and six-minute walking test (6mwt) will be used for evaluating the how dyspnea limits the patients' daily activities and functional capacity, respectively. isometric muscle strength will be measured with a handheld dynamometer of quadriceps femoris. fear of falling will be assessed with activities-specific balance confidence (abc) scale. the level of dyspnea during daily activities will be assessed with london chest activity of daily living (lcadl) scale. the global impacts of copd symptoms on overall health status will be evaluated by the copd assessment test (cat). pulmonary function data will be retrieved from the last 1-month clinical records of the copd patients. statistical analysis will be performed using the statistical package for social sciences (spss) version 21.0. descriptive statistics of continuous variables will be presented with mean, standard deviation (sd), confidence interval (ci) values, and descriptive statistics of categorical variables will be presented with frequency and percentage values. the conformity of the data to the normal distribution will be evaluated with the "shapiro wilk test". according to the results of the analysis, "pearson correlation test" or "spearman correlation test" will be used to determine the relationship between dependent variables. the significance level will be set as p\<0.05.

Eligibility criteria:
inclusion criteria: 1. stable disease (no severe exacerbations in the prior 3 months) 2. ability to walk independently 3. ability to read and write in turkish 4. able to follow simple instructions 5. no pathology in visual ability and hearing exclusion criteria: 1. a history of specific balance problems (i.e., diagnosed vestibular or neurological disorder) 2. severe musculoskeletal, neurological or cardiovascular disorders that limit mobility 3. use of medication(s) that may increase the risk of falls 4. participate in pulmonary rehabilitation in the lasts six months
project cope-spain (coping options for parent empowerment)

Conditions: Anxiety Symptoms; Depressive Symptoms; Parental Stress

Summary: the goal of this study trial is to establish the preliminary clinical utility of the cope program (coping options for parent empowerment) adapted for caregivers of adolescents in the spanish context. this program aims to improve parents' emotional well-being, enhance their parenting skills, and promote positive changes in their childrens' emotional and behavioral well-being. this study will adapt the cope program for in-person group administration in the spanish context, specifically in the school setting.

the research project, titled "cope-spain: adapting project cope (coping options for parent empowerment) for caregivers of adolescents in the spanish context," aims to evaluate the preliminary clinical utility of project cope (coping options for parent empowerment). project cope was developed at the university of miami, with dr. jill ehrenreich-may as the principal investigator, and has been evaluated in several studies. this protocol consists of a brief, structured intervention delivered in four group sessions, designed to improve parents' emotional well-being, strengthen their emotional regulation skills, and foster a positive family environment. initially, project cope was developed to help caregivers of children during the covid-19 pandemic and was later administered to caregivers of children with autism spectrum disorder (asd). the present study seeks to adapt project cope to be administered to caregivers of adolescents (instead of children) as an in-person group program implemented in the school setting.

Eligibility criteria:
inclusion criteria: * being a parent or legal guardian of an adolescent enrolled at ies isaac newton during the 2024-2025 academic year. * participants must have availability to attend all four program sessions at the scheduled time. exclusion criteria: * current psychological treatment: the parent or legal guardian is currently receiving individual psychological treatment and/or family therapy. * psychiatric medication changes within 4 weeks prior to the study and/or psychiatric medication changes during the study.

Keywords: adolescents transdiagnostic school cope up-a up unified protocol spain
a multicenter cross-sectional study on mental health of patients with multiple myeloma

Conditions: Psychological Distress; Insomnia; Somatic Symptoms

Summary: multiple myeloma patients with normal ability of communication and understanding will be enrolled. dt, gad-7, phq-15 and psqi scales are designed to assess the mental health status of the patients. demographic and disease data of patients will be collected as well. the main aim is to explore the factors affecting the mental health of myeloma patients.


Eligibility criteria:
inclusion criteria: 1. patients with symptomatic multiple myeloma were diagnosed according to the criteria of chinese multiple myeloma diagnosis and treatment guidelines (revised in 2022). 2. age ≥18 years, with junior high school education or above. patients have normal ability of communication and understanding. 3. informed consent has been signed. exclusion criteria: 1. who has kinship with other enrolled patients. 2. life expectancy of\< 6 months.

Keywords: multiple myeloma mental health
hepatitis c screening alerts

Conditions: Hepatitis C

Summary: the objective of this study is to evaluate whether alerts that identify patients without hepatitis c infection to healthcare providers and clinic staff can increase the uptake of screening for hepatitis c. a period of time without alerts will be compared to a period of time with alerts.

an estimated 2.4 million people in the united states were living with hepatitis c virus (hcv) infection during the period of 2013-2016. there were 4,798 new cases of acute hcv infection reported to the centers for disease control (cdc) in 2020, but under ascertainment and underreporting of cases suggests that this number is less than 10% of all new hcv infections; as such, there were an estimated 66,700 new cases in 2020. one-time screening is recommended by both the cdc and the united states preventive services task force for asymptomatic adults (aged ≥18 years and 18-79 years, respectively). the american association for the study of liver diseases and the infectious diseases society of america additionally recommends annual testing for people who inject drugs and for hiv-infected men who have sex with men. unfortunately, hcv screening rates remain low. the objective of this before and after study is to evaluate if an hcv screening algorithm, disseminated as risk score alerts in the chorus™ disease management and clinical considerations report to healthcare providers and clinic staff, increases the uptake of hcv screening among patients who are hcv screening-eligible (i.e., not known to have current or prior hcv infection).

Eligibility criteria:
inclusion criteria: * 18+ years of age * in care at an aids healthcare foundation healthcare center * hcv screening eligible individuals who are hcv screening eligible include: * hcv unknown: never received an hcv antibody, rna, or genotype test * previously hcv negative, high-risk for hcv infection: hiv-infected men who have sex with men or people who inject drugs with ≥ 1 prior negative hcv antibody or rna test(s) who have not been screened in the prior 12 months exclusion criteria: * \<18 years of age * diagnosed hcv infection (i.e., reactive hcv antibody, detectable hcv rna test, or hcv genotype test) individuals with diagnosed hcv infection include: * acute hcv infection, untreated or in treatment * chronic hcv infection, untreated or in treatment * spontaneous clearance of prior hcv infection * sustained virologic response after direct acting antiviral therapy for prior hcv infection * treatment failure after direct acting antiviral therapy for prior hcv infection
mre scan for the assessment of differences in tissue stiffness between radiation necrosis and recurrent glioma in patients with previously treated gliomas

Conditions: Glioma

Summary: this trial uses magnetic resonance elastography (mre) to estimate tissue stiffness (hardness or softness of the tissue) in tissue that is affected by radiation treatment (radiation necrosis) and tumor tissue that has come back (recurrent) after treatment in patients with gliomas. diagnostic procedures, such as mre, may estimate the differences in tissue stiffness between radiation necrosis and recurrent glioma post treatment and ultimately lead to a more accurate diagnosis and/or surgery, and/or a better assessment of the disease's response to treatment.

primary objectives: i. to estimate the mean lesion stiffness in patients with radiation necrosis using magnetic resonance elastography (mre). ii. to estimate the mean lesion stiffness in patients with glioma recurrence using magnetic resonance elastography (mre). secondary objective: i. to investigate the mean lesion stiffness between radiation necrosis and glioma recurrence. outline: patients undergo mre over 10 minutes and then undergo standard of care magnetic resonance imaging (mri) of the brain with and without contrast at baseline. within 4 weeks after the initial mri and mre scans, patients may undergo standard of care biopsy to check the status of the disease. within 48 hours after biopsy, patients undergo standard of care mri to check the status of the disease. patients who do not undergo biopsy undergo standard of care mri 4-8 weeks after mre scan to check the status of the disease.

Eligibility criteria:
inclusion criteria * \>/=18 years old. * history of a pathology proven intracranial glioma (including idh mutant, idh wildtype or 1p19q co-deleted tumors) treated with chemotherapy and radiation. * the lesion of concern (t2 flair hyperintense or contrast enhancing lesion) is \> 2 cm * patient is able to understand and give consent to participation in the study. exclusion criteria * patients less than 18 years of age. * pregnant. * known allergy to gadolinium-based contrast agents. * renal failure as evidenced by a glomerular filtration rate (gfr) of less than 30 ml/min/1.73m2. * pacemakers, electronic stimulation, metallic foreign bodies and devices and/or other conditions that are not mr safe, which include but are not limited to: * electronically, magnetically, and mechanically activated implants * ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators and cardiac pacemakers * metallic splinters in the eye * ferromagnetic hemostatic clips in the central nervous system (cns) or body * cochlear implants * other pacemakers, e.g., for the carotid sinus * insulin pumps and nerve stimulators * non-mr safe lead wires * prosthetic heart valves (if dehiscence is suspected) * non-ferromagnetic stapedial implants * claustrophobia that does not readily respond to oral medication
a research study, looking at the characterization of treatment intensified (add on to metformin) real-world adult population with type 2 diabetes mellitus in india, pakistan and thailand.

Conditions: Diabetes Mellitus, Type 2

Summary: this study aims to describe demographics, clinical, treatment and healthcare resource utilization characteristics with a particular focus on those relating to cardiovascular disease in selected treatment intensified patients with type 2 diabetes in the real-world settings in india, pakistan, and thailand. the study will be based on data already recorded in participants medical record and no new tests or procedures are required as part of the study. the study will last for about 6 months and it does not affect participants current treatment.


Eligibility criteria:
inclusion criteria: 1. informed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol). 2. male or female, age above or equal to 18 years at type 2 diabetes mellitus (t2dm) diagnosis 3. year of birth 1928 or later (age blow 90 years old in 2017) 4. t2dm diagnosis in medical record on or after the date of local glp-1 ra marketing authorization 5. medical records documenting prior or ongoing treatment with metformin 6. medical records documenting treatment with other non-metformin t2dm drugs exclusion criteria: 1. previous participation in this study. participation is defined as having given informed consent in this study. 2. mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation. 3. patients with any diagnosis of type 1 diabetes mellitus (t1dm)
model development and temporal validation of the predictive factors for return to work after stroke rehabilitation

Conditions: Stroke

Summary: the purpose of the study is to develop a predictive model for return to work after stroke rehabilitation.

background return to work post stroke is a key milestone for many survivors of stroke; however, many cannot achieve this goal. based on the previous work by tay et al, independent predictive factors were identified for return to work post inpatient stroke rehabilitation. in further works by koh and tay with the same dataset put through different models such as lasso-full, lasso-routine, elasticnet-full, etc suggests that the good discrimination performance of the return-to-work prediction models during internal validation supports a multisite, external validation study. performing a temporal validation study is the interim step. a smaller part of the dataset could be used to further train the development model. significant economic costs are incurred because of stroke, which do not include further economic costs from the downstream loss of earnings and caregiver burden. existing prediction models of return-to-work have area under the receiver operating characteristic curves (aurocs) between 0.65 and 0.80. however, these models have not been assessed for calibration or clinical utility. no externally validated prediction model exists for return-to-work after stroke. there are advantages to having a prediction model. one of the concerns of patients and their families involve the loss of income as a result of stroke. the prediction model would help to prognosticate, as well as assist to set appropriate rehabilitation goals for the patient. suitable patients can be directed to return to work services, if necessary. health is related to one's employment and financial position. being able to return to gainful employment can result in better general and mental health5. people with disabilities employed in the past year reported better general and mental health than their peers with the same disabilities who were unemployed. this study could be completed in 1 to 2 years and a prospective study involving external validation can be simultaneously performed with nuhs collaborators over 2 to 2.5 years. both projects could be published in the next 2 to 3 years upon obtaining the grant for the temporal validation study. thereafter, a return to work calculator could be designed and launched in the next 4 years. hypothesis this study seeks to collect 1375 patient data who had completed inpatient stroke rehabilitation between the time periods of 2018-2025. we seek to further train our development model and to perform a temporal validation on this model.

Eligibility criteria:
inclusion criteria: 1. completed inpatient stroke rehabilitation in cgh 2. diagnosis of a first ever stroke 3. patients who were working prior to stroke 4. consent given exclusion criteria: 1. not first ever stroke 2. did not require inpatient stroke rehabilitation 3. not working prior to stroke 4. no consent obtained

Keywords: return to work stroke rehabilitation stroke model development temporal validation
continuation protocol for obstructive sleep apnea (osa)

Conditions: OSA

Summary: the combination drug composed of aroxybutynin and atomoxetine, designated ad109, is being developed by apnimed for the treatment of obstructive sleep apnea (osa). the present study is a phase 3 open label continuation protocol enrolling qualifying participants who completed one of the parent phase 3 double-blind placebo-controlled studies, apc-apn-304 or apc-apn-305.


Eligibility criteria:
inclusion criteria: * completion of apc-apn-304 without permanent discontinuation of imp. * completion of apc-apn-305 without permanent discontinuation of imp. exclusion criteria: * participants are excluded from the study if participation would be considered unsafe by the investigator based on the individual's current status. * participants are excluded from the study if participation would be considered unsafe by the investigator based on concomitant therapies.

Keywords: obstructive sleep apnea
effect of using virtual reality goggles on fear and pain level during vaccination in children

Conditions: Fear of Pain; Fear; Virtual Reality; Pain; Vaccination; Children

Summary: the study was designed as a randomized controlled experimental research with the purpose of determining the effect of distraction by using virtual reality glasses reducing fear and pain during routine vaccination in children.

in the literature, it is stated that nurses should use pharmacological and non-pharmacological methods in pain and anxiety management in painful procedures. evidence-based studies are needed to show the effectiveness of non-pharmacological methods in reducing pain during invasive procedures and to investigate the effects of easy-to-apply methods on pain. in light of this information, this study aimed to examine the effect of distraction by using virtual reality glasses in reducing fear and pain during routine vaccination in children. this study is a prospective, randomized and controlled trial. children aged 48 months who required routine vaccination were divided into two groups; virtual reality glasses and control. data were obtained through face-to-face interviews with the children, their parents, and the observer before and after the procedure. the children's anxiety levels were also assessed using the children's fear scale. the children's pain levels were assessed and reported by the parents and observers and the children themselves who selfreported using wong-baker faces. the study population consisted of the children's during routine vaccination in children aged 48 months. sample of the study consisted of a total of 64 children who met the sample selection criteria and were selected via randomization method. children were randomized into two groups: virtual reality glasses group (n= 32) and control group (n= 32). data were collected using the interview and observation form, children's fear scale, and wong-baker faces pain rating scale.

Eligibility criteria:
inclusion criteria: * children the ages of 48 months, * volunteering of the child and parent to participate in the study, * healthy children, * vaccination should be done by the same nurse, exclusion criteria: * the child has any acute or chronic disease, * the child has a mental disability, vision, speech or communication problems, * the parent has hearing, vision or verbal communication difficulties, * the child used analgesics in the last 6 hours, * infection, disruption of skin integrity and rash in the area where the application will be made, * exclusion criteria were that the parent or child wanted to leave the study at any point.

Keywords: fear pain virtual reality vaccination child children
misoprostol for management of women with an incomplete miscarriage

Conditions: Miscarriage

Summary: miscarriage is defined as the spontaneous loss of a pregnancy before 24 weeks gestation, that is, before fetal viability. the clinical signs of miscarriage are usually vaginal bleeding associated with abdominal pain and cramping. the miscarriage is named 'complete' or 'incomplete' according to whether or not tissues are retained in the uterus. if a woman has minimal bleeding but her cervix is closed, this is known as a 'threatened miscarriage. however; if the pregnancy is still inside the uterus but the cervix is open, this is described as an 'inevitable miscarriage', which it will not usually be possible to save the fetus.

the aim of the study is to evaluate 2 doses with misoprostol in women with incomplete first-trimester miscarriage after misoprostol treatment

Eligibility criteria:
inclusion criteria: * women with confirmed incomplete induced miscarriage, less than 12 weeks' gestation. * no known allergy to misoprostol. * women who will be hemodynamically stable. * good access to emergency facilities exclusion criteria: * women with signs of severe infection ( fever \> 38°) * women with severe vaginal bleeding * women are known to have allergies to prostaglandins * severe abdominal pain requiring immediate intervention