Kornimate/medical-research-clean huggingface dataset:
growth hormone deficiency in chronic heart failure: a preliminary trial

Conditions: Heart Failure; Growth Hormone Deficiency; Ischemic Heart Disease

Summary: the aim of this study is to investigate the potential benefits of the correction of growth hormone (gh) deficiency with gh replacement therapy in patients with chronic heart failure due to left ventricular systolic dysfunction.

to date, a wide range of alterations in the gh/igf-1 axis have been described in patients with chronic heart failure (chf): reductions in gh levels, reductions in igf-1 and a pattern of peripheral resistance to gh, in particular in patients with severe heart failure and cardiac cachexia. unpublished experience of our group support the concept that a considerable amount of chf-patients have a coexisting growth hormone deficiency (ghd), defined by current guidelines(gh stimulation test). our study hypothesis is that correction of gh deficiency in patients with chronic heart failure may exert a beneficial effect on their cardiac function and remodeling, performance status and quality-of-life. since this was a preliminary study, no sample size calculation was performed; treatment effects from were sought in left ventricular function (as assessed by cardiac mri), cardiopulmonary exercise performance, clinical status, vascular reactivity, biochemistry and neurohumoral markers of disease (nt-probnp).

Eligibility criteria:
inclusion criteria: * heart failure in ew york heart association functional class ii to iv * left ventricular end diastolic diameter \> 60 mm * left ventricular ejection fraction \< 40% * growth hormone deficiency (defined as a peak gh response to intravenous stimulation with ghrh + arginine \< 9 ng/dl) * age 18-80 years * clinical stability, guideline-oriented maximal pharmacological therapy * informed consent exclusion criteria: * active myocarditis * hypertrophic cardiomyopathy * active endocarditis * active malignancy * end stage renal disease * severe liver disease (child b-c)

Keywords: heart failure growth hormone anabolism anabolic deficiency hormone replacement
the effect of bowel preparation status on the polyp missing rate

Conditions: Colorectal Polyps; Colonoscopy; Bowel Preparation; Polyp Missing Rate

Summary: high quality bowel cleaning preparation was most important prerequisites of a accurate colonoscopy, because even a small amount of residual fecal matter can obscure small polyps and increase unnecessary procedure time. until now, several studies evaluated the impact of bowel preparation on the quality of colonoscopy using comparison of the polyp detection rate in patients with adequate bowel preparation status to that in patients with inadequate bowel preparation status during colonoscopy. however, there was no direct measurement the effect bowel preparation status on the polyp missing rate, the quality of colonoscopy, using tandem colonoscopic evaluation in prospective setting.

1. study flow 1. all patients perform colonoscopy * record the polyp size, shape, location and number * record the factors affecting polyp missing rate * patients' age / gender * indication of colonoscopy * colonoscopist career * colonoscopy withdrawal time * bowel preparation status according to scale of u.s. multi-society task force on colorectal cancer, aronchick's scale and ottawa bowel preparation quality scale 2. the patients needed or wanted to 2nd stage colonoscopic polypectomy (2nd stage polypectomy was performed within 6 month) * record additionally detected polyp - size, shape, location and number

Eligibility criteria:
inclusion criteria: * the patients underwent colonoscopy and 2nd stage colonoscopic polypectomy at konkuk university medical center exclusion criteria: * colonoscopy was not reached the caecum * the patients with 10 or more polyps (who suspected polyposis syndrome) * bowel preparation was inadequate when 2nd stage colonoscopic polypectomy * the patients with inflammatory bowel disease or suspected inflammatory bowel disease * the patients had a history of bowel resection
full thickness resection or endoscopic submucosal dissection for difficult colorectal lesions.

Conditions: Colorectal Neoplasms

Summary: compare the efficacy and safety of endoscopic resection a full thickness (eftr) with full thickness resection device (ftrd) system versus endoscopic submucosal dissection (esd) in the treatment of laterally spreading tumor non granular type (lst-ng), "no lift" lesions colon and residual / relapse on scars from previous resections endoscopic colon. the dimensional cut off of these lesions is ≤30mm


Eligibility criteria:
inclusion criteria: * patients of age \>18 years * laterally spreading tumor non granular type (lst-ng) ≤ 3cm in diameter * "no-lift" colic injuries ≤ 3cm in diameter * residual / recurrence on the scar of previous endoscopic resections of the colon ≤ 3cm in diameter exclusion criteria: * pregnant women * failure to accept or understand the consent to participate in the study * patients with severe coagulopathies * patients with short life expectancy (charlson comorbidity index ≥8) * patients with expired general clinical conditions (american society of anesthesiologists score ≥3)
predictive values for the outcome of genicular nerve radiofrequency ablation for chronic knee pain

Conditions: Osteoarthritis, Knee

Summary: researchers are trying to assess a predictive value or correlation between patient and procedural characteristics and outcome measures results after genicular nerve radiofrequency ablation.

genicular nerve radiofrequency stimulation procedure is an effective treatment for patients with chronic pain due to knee osteoarthritis; however, little is known about factors that predict procedure success. this study evaluated correlation between patient characteristics and procedural characteristics and pain improvement after ultrasound guided genicular nerve radiofrequency stimulation procedure.

Eligibility criteria:
inclusion criteria: * patient's 18 years or older * patients who recently underwent ultrasound guided genicular nerve radiofrequency (rf) procedure exclusion criteria: * lack of documentation of predictive factors to assess outcome * patients in whom adequate follow-up data was not available * patients who were prescribed a new analgesic drug or received concurrent treatments for different pain sources during the follow-up period, that could affect interpretation of genicular rf treatment results.
a united states study of corlux for psychotic symptoms in psychotic major depression

Conditions: Major Depressive Disorder; Psychotic Disorders

Summary: corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress, triggering a healthy stress response. people who suffer from psychotic major depression may have unusually high levels of cortisol circulating within them or abnormal patterns of cortisol levels, overloading the stress response mechanism and causing symptoms of psychosis such as delusional thoughts or hallucinations. if corlux can keep the body's cortisol receptors from being overloaded, the stress response system may return to normal function, which may result in improvement of symptoms. the purpose of this 56 day study is to learn the safety and effectiveness of corlux in patients who have been diagnosed with psychotic major depression (pmd).


Eligibility criteria:
inclusion criteria: individuals eligible for enrollment into this study are male and female adult patients who: * are 18 to 75 years of age * have a diagnosis of major depressive disorder with psychotic features (dsm-iv 296.24 or 296.34) * are able to provide written informed consent exclusion criteria: individuals not eligible to be enrolled into the study are those who: * have a major medical problem * have previously participated in a corlux (c-1073, mifepristone) clinical trial * have a history of an allergic reaction to corlux (c-1073, mifepristone)

Keywords: pmd psychotic major depression depression major depression psychosis
treating deep seizure foci with noninvasive surface brain stimulation

Conditions: Epilepsy, Temporal Lobe

Summary: the overall goal of this study is to open up the promising treatment of repetitive transcranial magnetic stimulation (rtms), which has been shown to be effective against seizures in patients with surface neocortical foci, to a much larger population of patients with mesial temporal lobe epilepsy (mtle) and other forms of epilepsy with deep foci, who are not currently considered good rtms candidates. the investigators hypothesize that rtms can modulate the hyperexcitable state in patients with deep seizure foci by targeting its usage to accessible cortical partner regions. in this study the investigators aim 1) to map the functional connectivity of the epileptogenic mesial temporal lobe in patients with medically refractory mesial temporal lobe epilepsy; and 2) to perform a randomized controlled assessment of repetitive transcranial magnetic stimulation protocols applied to specific neocortical targets in mesial temporal lobe epilepsy. the methods used in this study will include magnetic resonance imaging (mri) of the brain, electroencephalography (eeg), and transcranial magnetic stimulation (tms).


Eligibility criteria:
inclusion criteria: * diagnosis of mesial temporal lobe epilepsy based on the combination of clinical semiology, neuroimaging findings, and electroencephalogram results. * at least 1 seizure with loss of awareness per 4-week period, on average, despite the use of antiepileptic drugs exclusion criteria: * prior brain surgery or exposure to transcranial magnetic stimulation * rapidly progressive brain lesions * inability to tolerate mri or tms * specific mri or tms contraindication as set forth in standard protocols of our institution
effect physical exercise in morbid obesity

Conditions: Morbid Obesity

Summary: this objective study to verify the effect of physical training with and without behavioral cognitive therapy, compared with controls, in functional capacity and cardio-metabolic profile in individuals with morbidly obese

this study is a randomized clinical trial, with individuals with morbid obesity, and will be consists of 3 groups: 1. group 1 (g1 exercise): this group will participate in an physical exercise program twice a week in hospital. 2. group 2 (g2 - lifestyle and exercise): this groups will receive the same g1 intervention associated with a weekly group followed up with techniques of cognitive behavioral therapy with a psychologist 3. group 3 (g3 - control): this group will keep medical appointments information and routine procedure in the hospital. will be included in study the individuals with morbid obesity who do not have contraindications to practice low-intensity exercise. exclusion criteria are contraindications to physical exercise, individuals with cardiovascular disease with reduced functional capacity (class iii and iv of the new york heart association), orthopedic problems, severe retinopathy, severe neuropathy, drug addicts and severe mental illness, metabolic or blood pressure decompensated.

Eligibility criteria:
inclusion criteria: * individuals with morbid obesity * individuals do not have contraindications to practice low-intensity exercise. exclusion criteria: * contraindications to physical exercise * cardiovascular disease with reduced functional capacity (class iii and iv of the new york heart association) * orthopedic problems * severe retinopathy * severe neuropathy * drug addicts and severe mental illness * high blood pressure or metabolic decompensation

Keywords: exercise morbidity obesity
total hip arthroplasty: fast track protocol is the future?

Conditions: Hip Osteoarthritis; Arthropathy of Hip

Summary: fast-track total hip arthroplasty (tha) is a well-established concept including optimized logistics and evidence-based treatment, focusing on minimizing surgical stress and improved post-operative recovery. the aim of this protocol is to compare the standard care and fast track total hip arthroplasties in terms of functional and subjective outcomes, hospital staying, number of transfusions and analgesic consumption.

the aim of this protocol is to compare standard care and fast track total hip arthroplasties. the fast track care consists of: * preoperative educational lesson in which orthopedic surgeon, anesthesiologist and physiotherapist illustrate the operative and post operative path to the patients * antalgic protocol administered only orally * early rehabilitation care. the day of the surgical operation, the physiotherapist helps the patient reach the upright position. the standard care consists of usual antalgic and physiotherapy post-operative care: * antalgic protocol consist in intravenous drugs * the first physiotherapy session is the day after surgery.

Eligibility criteria:
inclusion criteria: * patients affected by hip osteoarthritis, eligible for primary total hip arthroplasty * bmi \< 32 * time up ang go test \</= 12 seconds * american society of anesthesiologists physical status classification system (asa) \</= 2 * preoperative hemoglobin (hb) \>13 g/dl * patients eligible for spinal anesthesia * presence of a care-giver exclusion criteria: * psychiatric diseases * preoperative use of crutches * asa \> 3 * preoperative hb \< 13 g/dl

Keywords: fast track care total hip arthroplasty
study to proof the clinical and bacteriological non-inferiority of ampicillin/amoxicillin versus moxifloxacin in hospitalized patients with non-severe community-acquired pneumonia

Conditions: Community Acquired Pneumonia

Summary: the purpose of this study is to prove the clinical and bacteriological non-inferiority of ampicillin/amoxicillin versus moxifloxacin in hospitalized patients with non-severe community-acquired pneumonia.


Eligibility criteria:
inclusion criteria: * men or women older than 18 years with signed informed consent * women in a childbearing age with sufficient conception protection or if necessary negative pregnancy test * infiltrates appeared newly in the x-ray thorax * breath-conditioned chest pain * at least two of the following clinical symptoms of a pneumonia: * cough which is newly appeared or increasing, * dyspnea * mucopurulent or purulent sputum, * fever (body temperature \>= 37.8 degrees celsius auricalary and/or \>= 38,3°c rectal), positive auscultation * negative legionella antigen test in the urine * crb-65-index \< 3 exclusion criteria: * hospitalization within the last 28 days (except for the last 72 h) * participation in another therapy study within the last 4 weeks with studies admission * intake of an antibiotic longer than 24 hrs within the last 72 hours before studies admission * patients in the pregnancy and nursing phase * existence of contraindications opposite the examining preparations or other b-lactam antibiotics or fluorochinolons * patients with a curb-index \>= 3 * patients with suspicion of retrostenotic pneumonia because of bronchial obstruction * patients with suspicion of nosocomial pneumonia * patients with an infection by a known or suspected resistant pathogene

Keywords: ampicillin amoxicillin moxifloxacin community-acquired pneumonia
effectiveness of inelastic lso versus standard medical treatment for back pain associated with kyphosis

Conditions: Kyphosis; Back Pain

Summary: the objective of this study is to evaluate clinical effectiveness and the effect on quality of life of an inelastic thoracolumbarasacral orthosis in male and female hyperkyphotic patients with moderate to severe back pain disability and to demonstrate the safety of the intervention through detailed reporting and analysis of adverse events.


Eligibility criteria:
inclusion criteria: * patients with moderate to complete disability (crippled) as defined by a score of 21% to 80% on the baseline evaluation of the oswestry back pain disability questionnaire; * patients diagnosed with kyphosis and have a cobb angle of at least 55 degrees; * willing and able to comply with the study procedures and provide written informed consent to participate in the study. exclusion criteria: * patients under the age of 19; * pregnant patients or patients who are considering future pregnancies; * patients who were participating in any other investigational device or drug study or whose participation in a previous investigational study within 30 days of study entry may, in the opinion of the clinical investigator, impact analysis of this orthotic; * patients who, in the clinical judgment of the investigator, are not suitable for this study; patients who, in the investigators opinion, are mentally or legally incapacitated preventing informed consent or unable to read or understand written material; * patients who are unable or unwilling to return to the study center for follow-up visits.
trial to evaluate the efficacy of the hlpfc coil deep transcranial magnetic stimulation system in treating attention deficit and hyperactivity disorder (adhd) in adults

Conditions: Attention Deficit Disorder Patients

Summary: the aim of the study is to investigate the efficacy of trans-cranial magnetic stimulation in treating attention deficit disorder in adults.


Eligibility criteria:
inclusion criteria: * 18-65 years * add/adhd exclusion criteria: * any dsm-iv psychiatric disorder except add/adhd * use of psychoactive medications * epilepsy * brain injury

Keywords: age 18-65
a trial of cmna combined with concurrent chemoradiotherapy for locally recurrent escc

Conditions: Esophageal Neoplasms

Summary: this is a perspective, multicenter,single arm, open study to evaluate the efficacy and safety of treatment with cmna combined with concurrent chemoradiotherapy in patients with locally recurrent squamous cell esophageal carcinoma . analyses of primary objective (orr) will be done as defined in the protocol.

the primary end point of this study is objective response rate.the secondary end point is os, pfs and the safety of drug. the primary hypothesis is the cmna will improve orr and thus improve os, pfs. assuming bilateral a=0.05, statistical power of 80%. the total sample size is 40 cases.

Eligibility criteria:
inclusion criteria: 1. signed written informed consent prior to study entry 2. patients with recurrent escc after radiotherapy, confirmed by imaging and pathology or cytology; 3. capable for chemo-radiotherapy; 4. the existence of measurable lesions; 5. ecog ps of 0 or 1 6. possible semi-liquid diet; 7. expected lifetime≥3 months 8. normal bone marrow reserve: anc count ≥1500/mm3;platelet count ≥100,000/ mm3,hemoglobin≥9g/dl 9. normal hepatic function:bilirubin level ≤1.5×uln;ast/alt≤1.5×uln 10. normal renal function: serum creatinine≤1.5mg/dl and calculated creatinine clearance ≥60ml/min 11. normal cardiac function 12. subjects tumor tissue available for the relevant biomarker detection 13. clinical stage: no distant metastasis exclusion criteria: 1. female subject who is during pregnancy or lactation, and the subject who have fertility don't take effective contraception during study 2. any mental illness or nervous system lesions or can't tell treatment response clearly (such as cerebrovascular accident sequelae) 3. any serious uncontrolled disease and infection, such as severe heart, liver, kidney diseases or diabetes, can't complete the treatment plan 4. patients who have other malignant lesions, except curable skin cancer (non-melanoma skin cancer),carcinoma in situ of cervix or serve disease cured for 5 years 5. patients with distant metastasis. 6. patients who have obvious esophageal ulcers or have above moderate pains in chest-back or have symptoms of esophageal perforation 7. received anti-cancer treatment of esophageal cancer before the group, including surgery, radiotherapy, chemotherapy (induction of chemotherapy before the group is greater than or equal to two cycles) 8. not esophageal squamous carcinoma confirmed by pathology or cytology 9. history of active hepatitis 10. unable to comprehend the study requirement or who are not likely to comply with the study requirements 11. significant disease which, in the investigator's opinion, would exclude the patient from the study
psychosocial training for pediatric health care providers

Conditions: Mental Disorders Diagnosed in Childhood

Summary: this study will provide psychosocial training to general health care providers to help them provide better care to children with mental health problems.

up to 20% of school-age children have one or more mental health conditions that require treatment. these conditions are often treated by generalists. however, a significant proportion of children who seek treatment from generalists do not receive effective treatment. studies indicate that generalists who treat adults can improve the administration of treatment after taking part in training programs, but these studies have yet to be translated into pediatric settings. this study will conduct a training program to help generalists provide effective treatments to children with mental health problems. this study will evaluate a two-session, highly interactive training program in which general clinicians receive psychosocial training. the training program includes skills related to engaging parents and children, problem identification, solution-focused cognitive therapy, and making effective mental health referrals. the child's mental health symptoms, functioning, changes in utilization of pediatric services, and utilization of community services will be measured along with the mother's emotional well-being and family functioning.

Eligibility criteria:
inclusion criteria for health care providers: * generalist clinician in primary care practice seeing children 6 to 16 years of age inclusion criteria for patients: * 6 to 16 years of age * seeing a study-enrolled provider * english or spanish speaking * not in acute pain

Keywords: child adolescent