Kornimate/medical-research-clean huggingface dataset:
virologic and immunologic characteristics of severe mpox in persons with advanced hiv

Conditions: Monkeypox; HIV Infections; AIDS

Summary: the purpose of this study is to examine the extent of mpox viral spread and immunologic markers in people with advanced hiv. study findings will enhance knowledge of mpox pathogenesis in severely immunocompromised people, which can inform treatment and prevention of severe illness and deaths associated with mpox in people with advanced hiv.

primary objective: describe the relationship between the systemic immunologic response and the persistence and replication competence of mpox virus at rash lesions, in blood, and at mucosal sites over the course of mpox illness among patients with advanced hiv. secondary objectives: * describe the association between clinical outcomes and virologic and immunologic parameters among patients with severe mpox and advanced hiv. * survey for emergence of antiviral drug resistance among mpxv isolates collected over time during mpox illness among patients with advanced hiv. * characterize the effects of antivirals to treat mpox and/or hiv infection on virologic and immunologic parameters among patients with mpox and advanced hiv. * assess persistence and replication competence of mpox virus in the oropharynx and rectum over the course of mpox illness among patients with advanced hiv.

Eligibility criteria:
inclusion criteria: * age ≥18 years; and * hiv infection with cd4 count \< 200 cells/ul; and * probable or confirmed mpox (does not need to be a new diagnosis); and * hospitalized while symptomatic from mpox, for reasons other than (or in addition to) infection prevention and control exclusion criteria: * inability of the individual or appropriate proxy to provide informed consent. * in the judgment of the clinical treating team, has a medical condition or other factor that might affect their ability to participate in the evaluation.
the muti-centered investigation，pathogenesis and intervention study of non-suicidal self-injury behavior in china

Conditions: NSSI

Summary: non-suicidal self-injury (nssinssinssi) refers to a series of direct and consequently repeated injuries to one's body without suicidal intent. at present, it has become an important issue of mental disorders. this study is expected to complete a multi-center epidemiological survey of non-suicidal self-injury in china, and to study its pathogenesis and intervention methods.

(1) nssi nssi epidemiological survey. for example, epidemiological investigation. for example, in the period of 2020.1.1-2020.6.30 half a year, the psychiatric departments of fourteen hospitals of different regions, regions and nature (psychiatric specialist hospitals/general hospitals), hospitals of different types in jiangsu province, and hospitals of different types in jiangsu province were selected by stratification. in outpatient and inpatient departments, a certain proportion of young people were selected from outpatients and inpatients. guided by the recommended diagnostic criteria of dsm-5 and guided by semi-structured interviews, the patients with nssi behavior were screened out by semi-structured interviews. the incidence, comorbidity, incidence, comorbidity and basic psychosocial factors were investigated.(2) exploring the pathogenesis of nssi. exploration of pathogenesis. a case-control study was designed on the basis of flow survey. the nssi nssi group and the normal control group were set up. the data of symptomatology, genetic factors of social factors of psychological cognitive function and brain imaging were collected. the data of brain imaging, brain imaging and other data were collected, and the data of social-psychological-biological data collection and mechanism exploration were carried out.(3) clinical intervention study of nssi. nssi patients were randomly divided into structured dbt group intervention group (dbt-st) and support group discussion group (sgt). the experimental group was given structured dbt group therapy intervention, while the control group was given the same frequency of support group discussion. to explore the therapeutic effect and mechanism of structured dbt group therapy intervention on nssi behavior. in order to provide a scientific and effective treatment for nssi behavior.

Eligibility criteria:
inclusion criteria: 1. 10-40 years old; 2. voluntary participation, signing informed consent and obtaining the consent of family members of patients under 18 years old; exclusion criteria: 1. history and family of neurological or psychiatric disorders; 2. history of psychiatric disorders and family history; 3. severe somatic diseases; 4. taking psychotropic drugs within three months; 5. pregnancy and lactation
clinical evaluation of safety and efficacy of refrigeration free latanoprost

Conditions: Glaucoma, Open-Angle; Ocular Hypertension

Summary: the purpose of this study is to: * to evaluate the efficacy of refrigeration-free latanoprost compared to latanoprost stored at refrigeration temperature with respect to the diurnal intraocular pressure (iop) change from baseline after 3 months of therapy in patients with open-angle glaucoma (oag) or ocular hypertension. * to evaluate the safety and tolerability of refrigeration-free latanoprost in patients with open-angle glaucoma (oag) or ocular hypertension.

latanoprost refrigeration free formulation is developed to overcome difficulties on storing drugs at 2-8˚ c in consumer end and also to avoid risk during transition. this formulation has the best solubilizing agent cyclodextrin to increase the solubility and stability of latanoprost api. to find out the efficacy and safety due to this additional excipient in this formulation rather than the cold storage product the investigators have to perform clinical trial.

Eligibility criteria:
inclusion criteria: * patient between 18 and 80 years of age * newly diagnosed primary open-angle glaucoma, pigmentary glaucoma, pseudoexfoliation, or ocular hypertension. * patient has a mean (or median) iop of 24 and 36 mmhg in at least one eye * patient has a best corrected etdrs visual acuity score of +0.6 logmar (snellen equivalent of 20/80) or better in each eye. * patient should have the access / ability to refrigerate study drug. * residence with 60 kms of madurai exclusion criteria: * patient has a mean (or median) iop \>36 mmhg in either eye at the screening visit. * patient has a history of or current abnormal corneal sensation or any abnormality in either eye preventing reliable goldmann applanation tonometry * pupil in either eye that will not dilate sufficiently for adequate evaluation of the retina * patient has a history of retinal detachment, proliferative diabetic retinopathy, or any retinal disease in either eye that may be progressive during the study * patient who has significant ocular symptoms or signs such as photophobia, flashes or streaks of light, metamorphopsia, diplopia, or transient loss of vision in either eye. * patient has had intraocular surgery (e.g., cataract extraction) in either eye within 4months prior to screening visit. * patient is aphakic or has, in the judgement of the investigator, risk for ocular inflammation

Keywords: refrigeration free latanoprost
the effect of periodontal disease treatment in patients with kidney disease

Conditions: Periodontal Diseases

Summary: the purpose of the present study was to compare the effects of non-surgical periodontal therapy by clinical and biochemical parameters on patients undergoing continous ambulatory peritoneal dialysis(capd) due to diabetic nephropathy and non-diabetic

a new branch of periodontology, deﬁned as "medical periodontology," has been proposed that mentioned the bidirectional relationship between periodontal disease and systemic conditions. in the lights of these informations, the purpose of the present study was to compare the effects of non-surgical periodontal therapy on patients undergoing continous ambulatory peritoneal dialysis(capd) due to diabetic nephropathy and non-diabetic. forty three participants ( 22 diabetic nephropathy(dn) group , 21 non-diabetic nephropathy(n-dn) group) were included and divided into the two group; dn group and n-dn group, in the present study. the following clinical parameters were evaluated at baseline and the end of the study: plaque index ; gingival index ; pocket depth (pd) measurements; bleeding on probing (bop)-percentage of bop (+) sites; gingival recession (gr)-from the cement-enamel junction to the gingival margin; and clinical attachment level (cal)-the sum of pd and gr measurements. the decay-missing-filling index (dmft) was recorded. clinical examinations were repeated 6 months following periodontal treatment. all clinical measurements were taken from the mid-buccal and mid-lingual sites and the buccal aspects of the interproximal contact area for the mesial and distal sites of each tooth to the nearest 0.5 mm using a 15 mm periodontal probe at baseline and the 6th months after treatment. all periodontal clinical examinations were performed by one calibrated examiner (fot). at baseline and 6 months after treatment, fasting venous blood samples were collected from the antecubital fossa by an experienced nurse. blood samples for tnf- α, il-6 and ptx-3 were centrifuged, and separated serum and plasma samples were stored at -80◦c until analysis. tnf-α , il-6 , and ptx-3 serum levels were determined using a commercial solid-phase enzyme-linked immunosorbent assay (elisa) kit according to the manufacturer's instructions. periodontal treatments were performed 2 hours after the patients had their breakfast following the blood sampling. standard oral hygiene instructions were given to all groups, including interdental plaque control (interdental brushes) and brushing of the dorsum of the tongue twice a day. oral hygiene control and re-instructions were provided during all visits. after local infiltration, full-mouth scaling and root planning (fm-srp) was performed by the same investigator with standard periodontal curettes

Eligibility criteria:
inclusion criteria: * had to have chronic periodontitis * ≥15 natural teeth * needed to be \>30 years old exclusion criteria: * history of antibiotic or anti-inflammatory drugs within the previous 6 months * pregnancy or lactation * periodontal therapy within 6 months prior to the study * past or current smoking and alcohol consumption
intermittent art in primary hiv infection

Conditions: HIV

Summary: interventions during primary hiv infection (phi) can modify the immune control and the clinical evolution during the chronic phase. although several studies suggest the benefit of antiretroviral treatment (art) during phi, indication of art is still not universally recommended. the investigators randomized patients with phi, with a favourable immunological profile and well controlled on art, to undergone structured treatment interruptions alone or with low doses of il-2, stopping art thereafter. the endpoints were immune control of hiv replication and time to resume art. immunological profile, specific cd4 and cd8 responses and clinical data were analysed for both groups up to 48 weeks, and during a long follow-up, up to nine years since final art stop.

the study design included two phases. the first phase consisted in four sti of 8 weeks each (off-art), separated by 16 weeks of treatment -or the time necessary to reach again to pvl \<20 copies/ml- (on-art). at the end of the 4th off-art cycle (week 0) an interim evaluation was performed and the second phase initiated. during the second phase, the first 6 patients received art until they reach pvl\<20 copies/ml, discontinuing thereafter (final stop). the last 6 patients received art and low doses of il-2. arv therapy was stopped after reaching pvl\<20 copies/ml (final stop) and il-2 after 6 months of treatment. il-2 was prescribed at a dose of 750.000 ui/m2 daily and was self-administrated in all patients previous trained by a specialized nurse. art was resumed in patient dropping cd4 cell count less than 350 cell/mm3 in two consecutive determinations or in patients who developed opportunistic infections. a long term follow up analysis was performed at 3, 6 and 9 years since the final stop. it included time to resume art, clinical events, survival rate, cd4-cd8-cd4/cd8 ratio.

Eligibility criteria:
inclusion criteria: * phi defined by detectable plasma viral load (pvl) or p24 antigen detection coupled with a negative or indeterminate lia assay (according cdc criteria); negative hiv-1 eia in the preceding 90 days or by a positive eia and lia assay with acute retroviral syndrome in the preceding 90 days of starting art plus documented negative hiv-1 eia within the previous year. * art started within 90 days from the hiv exposure and continuing in the same treatment at least 12 months before the inclusion, and they must have shown good virological and immunological responses, defined as undetectable pvl (\ 1 in the last 8 months previous to enrolment exclusion criteria: * infection of more than 90 days. * age under 18 years old. * aids defining condition
randomized trial of casting techniques for displaced forearm fractures

Conditions: Displaced Forearm Fractures

Summary: it is recognized that fractures of the distal radius and forearm occur in approximately one in 100 children and adolescents every year. though closed manipulation and cast immobilization of displaced injuries is the mainstay of treatment in the majority of cases, the optimal type of cast remains debatable. though well-molded casts theoretically provide the best ability to maintain fracture alignment, risks of circumferential immobilization in acute injuries include neurovascular compromise. splitting, or bivalving, casts may reduce these risks, but the effect on fracture stability is unknown. the proposed investigation seeks to address the simple question of whether circumferential or bivalved casts provide the best outcomes.


Eligibility criteria:
inclusion criteria: * displaced distal radius or mid-diaphyseal forearm fracture * fracture requires closed reduction and cast immobilization * age 4-16 years * skeletally immature exclusion criteria: * failed closed reduction * acute fracture \> 1 week old * refracture injury * fracture requires surgical treatment * significant soft tissue swelling * associated neurovascular compromise * plastic deformation injuries

Keywords: casting techniques bivalved cast circumferential cast displaced distal radius fracture children
18f-asis pet/ct imaging of tissue factor expression in patients with primary and metastastic cancer

Conditions: Breast Cancer; Lung Cancer; Pancreatic Cancer; Ovarian Cancer; Cervix Cancer

Summary: the primary objective of the trial is to test the new radio tracer 18f-asis for pet imaging of tissue factor (tf) expression. the tracer has the potential of identifying tumors with high levels of tf expression, which is expected to correlate with tumor aggression and prognosis. furthermore, the tracer can potentially be used as companion imaging diagnostic agent for identifying patients eligible for tf directed therapies. this is a first-in-man study to test the radio tracer in cancer patients. safety, biodistribution and dosimetry will be evaluated by repeated pet imaging (1 hour, 2 hours and 4 hours post-injection).

the primary objective of the trial is to test the new radio tracer 18f-asis for pet imaging of tissue factor (tf) expression. the tracer has the potential of identifying tumors with high levels of tf expression, which is expected to correlate with tumor aggression and prognosis. furthermore, the tracer can potentially be used as companion imaging diagnostic agent for identifying patients eligible for tf directed therapies. this is a first-in-man study to test the radio tracer in cancer patients. safety, biodistribution and dosimetry will be evaluated by repeated pet imaging (1 hour, 2 hours and 4 hours post-injection). the primary end points are safety, biodistribution and dosimetry of 18f-asis. in addition, the quantitative uptake of 18f-asis will be compared to the expression of tf measured directly in tumor tissue obtained by surgery or biopsies. the study will be monitored and evaluated in accordance with the principles of good clinical practice (gcp).

Eligibility criteria:
inclusion criteria: * diagnosed with breast, lung, pancreatic, cervix or ovarian cancer * capable of understanding the patient information in danish and giving full informed consent exclusion criteria: * pregnancy * breast-feeding * weight above 140 kg * history of allergic reaction attributable to compounds of similar chemical or biologic composition to 18f-asis
oral health in children with inflammatory bowel disease

Conditions: Oral Health in Children With Inflammatory Bowel Disease

Summary: in adults with inflammatory bowel disease (ibd), a higher prevalence of dental caries and periodontal disease has been reported compared with healthy control subjects, but similar data on children are missing in the literature.we aimed to evaluate the prevalence of dental erosion, dental caries and periodontal disease in children with ibd.

in this age- and gender-matched prospective case-control study, detailed questionnaires including nutritional habits and oral examinations were completed for 32 ibd patients aged 11 to 18 (15,53±2,00 yr) and 32 healthy controls based on the established criteria of the world health organization by the same pediatric dentist.

Eligibility criteria:
inclusion criteria: * 11-18 years of age * study population with ibd in the remission period of disease * permanent dentition stage exclusion criteria: * those who refused or whose families refused participation in this study * study population with ibd in the active period of disease * primary or mix dentition stage * systemic conditions, or medications with impact on periodontal tissues and previous orthodontic or periodontal treatment within the last year. * smoking

Keywords: inflammatory bowel disease, children, permanent dentition, nutritional habits
effect of drainage on laparoscopic gastric bypass surgery

Conditions: Obesity, Morbid

Summary: introduction rygb surgeon; have become increasingly morbid obesity treatment methods with improvements in minimally invasive surgery. ensuring patient comfort and early return to life are the criteria that should be given priority in this treatment method. the purpose of this study is to determine the use of drain, which closely affects these criteria; and the effect on patient comfort.

question the necessity of routine use of drain in rygb surgeon

Eligibility criteria:
inclusion criteria: * morbid obese patients exclusion criteria: * cirrhotic patients, those under 18 years of age, additional intraabdominal surgeries during lrygbp and those who had previously undergone obesity surgery (revision surgery) were excluded

Keywords: obesity vas pain laparoscopy bypass
effects of a mobile app on adherence to daily exercise and recovery after whiplash injury

Conditions: Whiplash Injury of Cervical Spine

Summary: this study investigates the effect of daily mobile app reminders to exercise in conjunction with standard physical therapy on adherence to exercise and recovery after whiplash injury of the neck. participants will be divided into two groups, the experimental (arm a) and control group (arm b). both groups will complete a standard physical therapy program under the supervision of a physiotherapist. both groups will get illustrated home exercise programs and will be advised to continue exercising at home. in addition, the experimental group will receive one daily push notification via a mobile app to perform a daily exercise at home.

whiplash injury of the neck is the most common injury resulting from a traffic accident. although most people recover completely, 30 to 50% of them develop chronic neck pain and disability. also, long sick leaves and lower productivity at work create a burden on the healthcare system. conservative treatment includes exercise, physical therapy modalities such as transcutaneous electric nerve stimulation (tens), and ultrasound therapy. although conservative treatment is recommended, the evidence of its efficacy remains unclear. education after the injury can be beneficial in lowering anxiety and pain. many studies are investigating the usefulness of mobile apps in various medical conditions. in rehabilitation medicine, apps are used to increase knowledge about different conditions, as a measurement tool, and as an intervention to increase adherence to the prescribed therapy. after the enrollment in the study, participants will complete the two-part physical therapy program (2x10 sessions, 5times/day, 3-week break in between) under the supervision of a physiotherapist at the outpatient clinic. after completing the program, the participants will get a home exercise program, group a via mobile app, and group b via papers, and will be encouraged to continue exercising at home. also, group a will download a mobile app, "wiapp," that was developed for this purpose and will receive one daily push notification as a reminder to perform a daily exercise at home. the investigators hypothesize that daily reminding to exercise via mobile app can increase adherence to prescribed therapy and overall increase recovery.

Eligibility criteria:
inclusion criteria: * patients who sustained whiplash injury of the neck in a car accident as drivers or co-drivers * diagnosed with a whiplash injury of the neck by physical and rehabilitation medicine specialist within 3 months * neck disability index (ndi) score higher than 5 (10%) * possession of and ability to use a smartphone and a mobile app * age ≥ 18 years * signed written informed consent exclusion criteria: * bone fracture sustained in the accident * spinal cord injury * accident in any other type of vehicle other than car * treatment of malignant disease in the last 5 years * expected non-compliance (not possible to use a smartphone because of severe mental or physical impairment)

Keywords: whiplash adherence recovery mobile app
fenix™ continence restoration system registry

Conditions: Fecal Incontinence; Faecal Incontinence

Summary: the fenix registry is a multi-center, observational database designed to collect data regarding the fenix™ continence restoration system in everyday clinical practice, evaluate the clinical course of patients from pre-operative assessment through five years post-surgery and track and monitor effectiveness and safety through the use of a bowel diary, fecal incontinence quality-of-life measures and adverse event reporting. up to 25 sites will participate in the registry. sites to enroll consecutive eligible patients into the registry. registry will enroll approximately 200 fenix patients.


Eligibility criteria:
inclusion criteria: * individuals being treated with the fenix™ continence restoration system * individuals who have provided appropriate authorization per institutional policy and procedure to have clinical and health information collected for the fenix registry. * individuals willing to complete a 14-day bowel diary, questionnaires and comply with all required follow-up. exclusion criteria: * known circumstances that would make it unlikely for an individual to complete the five-year follow-up (e.g. life expectancy \<5 years)

Keywords: magnetic anal sphincter augmentation fenix™ continence restoration system magnetic anal sphincter