Kornimate/medical-research-clean huggingface dataset:
stereotactic directional vacuum-assisted breast biopsy

Conditions: Breast Cancer; Stereotactic Directional Vacuum-assisted Breast Biopsy; Female; Adult Patients

Summary: stereotactic directional vacuum-assisted breast biopsy (st dvab) is a standard biopsy procedure for suspicious findings on mammograms in western countries for more than 10 years \[1-3\], it has replaced the needle localization (nloc) excisional biopsy for the lesions alike and was reported to feature a high sensitivity, very low delayed false-negative rate (less than 2%)\[4,5\]. moreover, it causes less scarring, less psychologic stress to patients and less morbidity compared with needle localization excisional biopsy \[6,7\]. however, its sensitivity, accuracy has seldom been reported in asian countries \[8\] , since most asian women have different breast parenchyma pattern, different breast cancer prevalence. therefore, we retrospectively reviewed outcomes of the two groups of patients receiving either st dvab or nloc excisional biopsy, trying to investigate if st dvab can be an effective alternative to nloc excisional biopsy in our country.


Eligibility criteria:
inclusion criteria: * the indication for st dvab was lesions with suspicious nature for malignancy seen on mammograms which biopsy is necessitated for tissue proof, or probably benign or benign appearing lesions seen on mammograms but patients or clinicians requested biopsy exclusion criteria: -
self-locking tenodesis of the long chief of the biceps vs. lasso 360 tenodesis in arthroscopic rotator cuff repair rotator cuff repair

Conditions: Rotator Cuff Injury

Summary: the aim of this study is to compare the clinical results and complications of self-locking biceps tenodesis and double 360 lasso loop biceps tenodesis for the treatment of long chief of biceps or superior labrum anterior-posterior (slap) tendon pathology during shoulder arthroscopy in patients undergoing arthroscopic rotator cuff repair. currently, there is no consensus on the use of tenodesis versus tenotomy to treat pathology of the long head of the biceps during arthroscopic rotator cuff repair. numerous studies have examined the clinical results of long biceps tenotomy versus long biceps tenodesis, and there is no evidence to date of superiority of either technique. at clinique générale, we use a new, innovative technique called autobloc tenodesis to treat pathologies of the long head of the biceps. there are no comparative studies between autobloc tenodesis of the biceps and biceps tenodesis. given its potential advantages, self-locking biceps tenodesis could emerge as the new technique of choice for treating biceps longus tendon pathology, potentially reducing differences in outcomes such as popeye deformity. the information provided by this study could potentially guide future clinical practice, helping surgeons to choose the most appropriate treatment for their patients suffering from long biceps tendon pathology.


Eligibility criteria:
inclusion criteria: * full-thickness rotator cuff tear of the supraspinatus/infraspinatus tendon, diagnosed preoperatively by ultrasound, arthro-ct or mri. * patients must be able to read and write in french in order to complete the questionnaires and sign the informed consent form. exclusion criteria: * partial rotator cuff tear * massive and irreparable rotator cuff tear * grade 4 according to goutallier classification of fatty degeneration of rotator cuff muscles * rupture of the long biceps * hourglass deformity of biceps tendon origin * osteoarthritis of the glenohumeral joint, defined by narrowing of the glenohumeral joint space or osteophytes, using ap radiography of the affected shoulder. * distance between acromion and humeral head measuring 6 mm or less, defined by hamada classification as grade 2 or higher. * previous shoulder surgery. * dementia or inability to complete questionnaires and assessments. * pregnant, parturient or breast-feeding patients. * persons under legal protection (curatorship, guardianship, safeguard of justice). * persons deprived of their liberty by judicial or administrative measure * persons under psychiatric care * persons not affiliated to a social security scheme

Keywords: rotator cuff biceps long biceps tendon
acupuncture in chronic migraine: a randomized controlled trial

Conditions: Patients With Chronic Migraine

Summary: the aim of this study was to investigate the efficacy and tolerance of acupuncture treatment compared with pharmacologic treatment in patients with chronic migraines.besides, the investigators tested whether the clinical effects of acupuncture in chronic migraine prophylaxis are mediated by changes of the plasma cgrp (calcitonin gene-related peptide).

subjects who completed the prospective baseline periods and meet met the prespecified entry criteria will be randomized into 2 groups: acupuncture treatment, and topiramate treatment group. subjects will be allowed to continue taking acute migraine medications for the treatment of breakthrough attacks during the trial, but any migraine preventive medications will be prohibited. written informed consent was obtained from all participants before entering the study.

Eligibility criteria:
inclusion criteria: * age 18 to 75 years old * patients were required to have a diagnosis of chronic migraine with or without medication overuse that satisfied the ichd-2 criteria during the last 3 months prior to trial entry, with an established migraine history for at least 1 year. exclusion criteria: * patients did not fulfill the criteria of ≧ 15 days or response to triptans or ergots on at least 8 days in prospective baseline periods . * the presence of headaches other than chronic migraine (such as another primary chronic headache or any secondary headache). * migraine prophylaxis agents during last 3 months including β-blockers, anti-depressants, calcium channel blockers, anti-epileptic agents or cycle-modulating hormonal drugs. * migraine onset after age 50 or the age at onset of cm \> 60 years. * history of hepatic disorder, nephrolithiasis or other severe illness. * cognitive impairment interfering with the subject's ability to follow instructions and describe symptoms. * prior fearful experience of acupuncture. * bleeding diathesis or anticoagulation. * pregnant or nursing.

Keywords: chronic migraine acupuncture topiramate randomized trial
a pilot study of nutritional status in patients with huntington's disease

Conditions: Huntington Disease

Summary: it is known that weight loss is a poor prognostic marker in hd, but it is not known which dietary interventions are optimal at different stages of the disease. current guidelines for hd treatment are informed only by studies in people with other causes of weight loss. our long term goal is to create the evidence base for improved nutritional management in hd. this study will pilot the tools to inform the development of clinical trials protocols. we want to know which measures can be used by patients manifesting obvious clinical features of hd, and which are most helpful in detecting clinically meaningful changes in nutrition status.

huntington's disease (hd) is a complex autosomal dominant disorder of (generally) adult onset. the clinical features of hd are cognitive decline, psychiatric disturbance, personality change and movement disorder. although by eu definition a rare disease, better management and establishment of clinics for care of hd around the world have led to recognition of that the condition is much more common than previously considered. grampian has one of the longest established clinics for managing hd worldwide, and we now care for more than 150 people at different stages in hd, making us one of the largest five specialist clinics in the uk. members of our team have led the production of european guidelines for hd management, and within this project, we have highlighted the importance of nutrition in hd. weight loss is well documented as a clinical feature of all stages of huntington's disease (hd). however, its metabolic basis is poorly understood and appetite has not been formally studied in patients with the condition. furthermore, the composition of weight loss - muscle or fat has been little studied and modern nutrition assessment tools have not been applied in this cohort. it is known that weight loss is a poor prognostic marker in hd, but it is not known which dietary interventions are optimal at different stages of the disease. current guidelines for hd treatment are informed only by studies in people with other causes of weight loss. the long term goal of this study is to create the evidence base for improved nutritional management in hd. this study will pilot the tools to inform the development of clinical trials protocols. the aim is to identify which measures can be used by patients manifesting obvious clinical features of hd, and which are most helpful in detecting clinically meaningful changes in nutrition status.

Eligibility criteria:
inclusion criteria: * stage 2 or 3 huntington disease exclusion criteria: * unable to give consent
application of celiac plexus block in postoperative analgesia of whipple surgery

Conditions: Pain, Postoperative; Nerve Block

Summary: this subject intends to explore the value of intraoperative celiac plexus block in postoperative acute pain management and its promoting effect on patients' rapid recovery during whipple surgery through a randomized controlled trial.

this study is a single center, randomized, single-blind controlled study. after calculating the sample size, 66 subjects would be randomly assigned to nerve block group (nb group: local anesthetic injection at the target position) and blank control group (gc group: no celiac plexus block) according to the ratio of 1:1, in order to evaluate the effectiveness and safety of celiac plexus block (cpb) as a part of multimodal analgesia for postoperative pain management. anesthesia protocol: the standard anesthesia protocol for open whipple surgery in our hospital was adopted. postoperative analgesia plan: before abdominal closure at the end of operation, the surgeon was instructed to perform a single celiac plexus block (cpb) under direct vision. ropivacaine was injected into the target nerve in nb group, but no injection in gc group. after the operation, the anesthesiologist used ropivacaine to perform ultrasound-guided abdominal wall nerve block. when leaving the operating room, connect intravenous analgesia pump. patients with subjective pain score of 3 or above can press. if the analgesia is insufficient, intravenous injection of dezocine can be added temporarily. the intravenous analgesia pump shall be withdrawn after 72 hours of use. if the analgesia pump is used up and is still needed, the anesthesiologist can evaluate and add medicine.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18years; 2. received open whipple surgery. exclusion criteria: 1. patients unable to cooperate with evaluations; 2. patients with history of drug abuse, local anesthetic allergy, anatomical variation of the celiac ganglia indicated by abdominal ct, abdominal aortic diseases; 3. non-standard surgical procedures, planned postoperative icu admission; 4. american society of anesthesiologists (asa) classification of 4 or 5. withdrawal criteria: patients who underwent unplanned surgeries, required reintubation or a second surgery, received icu care within three days post-surgery, died within two weeks post-surgery, or experienced any unexpected events were withdrawn from the study.

Keywords: celiac plexus block
comparing targets of expressive writing

Conditions: Healthy; Anxiety; Depression

Summary: expressive writing involves writing about one's deepest thoughts and feelings surrounding an emotional event. the current literature on the efficacy of expressive writing is mixed and warrants further investigation into how, when, and for whom expressive writing is an effective intervention. the goal of this study is to compare the efficacy of expressive writing interventions in young adults when people imagine that they're writing to themselves vs. a loved one. participants will carry out an expressive writing exercise for 14 consecutive days. participants are randomized into 3 groups: self, other, and control. the self group is instructed to write as if they were talking to themselves. the other group is instructed to direct their writing to someone they feel close to. the control group is asked to write down a factual description of their routine that day, and direct this writing to themselves. we will recruit participants until we have usable data from 53 participants per group (i.e., 159 in total).


Eligibility criteria:
inclusion criteria: * us-based * fluent english * combined gad-7 and phq-8 score of ≥ 5 exclusion criteria: * "completion" of a writing session requires participants to spend at least 15 minutes on the writing page. we will monitor completion of the daily writing exercise, and will contact participants who miss or spend less than 15 minutes on the exercise. participants who fail to complete 3 consecutive daily writing sessions will be deemed non-compliant, removed from the study, and paid a prorated amount for the tasks they have completed in the study.

Keywords: expressive writing journaling mental health
age related differences in respiratory immune responses in influenza virus infection

Conditions: Influenza A Infection; Influenza B Virus Infection; SARS CoV 2 Infection; RSV Infection

Summary: the goal of this observational study is to understand immune responses to viral airway infection in adults, including the elderly. the main question(s) to answer is/are: why do some individuals acquire only asymptomatic or mild influenza a virus (iav) infection while others become severely ill and even succumb to the same disease? participants will be asked to donate samples when seeking health care for influenza-like symptoms or if hospitalized for iav or sars-cov-2. samples asked for are: * blood sample by venepuncture * blood sample by capillary sampling * nasopharyngeal aspirate * nasopharyngeal swab * endotracheal tube aspirate * nasal swab * nasal curette * breath explor (sampling of expired air) researchers will compare obtained results with the same type of samples from healthy controls.

this observational study will specifically investigate different immunological parameters in blood and at the site of infection in patients with iav symptoms or confirmed infection to understand parameters related to disease course. blood and airway samples will be analyzed for immune cell subsets and their functionality, antibodies and other soluble mediators and linked to clinical data. immune cells will be analyzed using multi-color flow cytometry, rna sequencing, and in vitro functionality assays. fluids (plasma, serum, supernatants from airway samples and cell culture supernatants) will be analyzed using elisa (and or similar methods), proximity extension assay (olink), etc.

Eligibility criteria:
inclusion criteria patients: * influenza a like symptoms and/or * confirmed airway infection exclusion criteria patients: * current malignancies * immunosuppressive treatment, not including/except hydrocortisone exclusion criteria controls: * airway infection within the past four weeks * ongoing antibiotic treatment * immunosuppressive treatment

Keywords: influenza a virus (iav) influenza b virus (ibv) sars cov 2 respiratory syncytial virus (rsv) immunology age-related differences
trial evaluating role of post mastectomy radiotherapy in women with node negative early breast cancer

Conditions: Breastcancer

Summary: postmastectomy radiotherapy (pmrt) is unequivocally beneficial in reducing the recurrences as well as improving survival in node positive breast cancer patients. pmrt for women with t1-t2 tumors and negative axillary nodes is not generally warranted because of the presumed low risk of recurrence in this population as a whole. however, in the setting of multiple adverse prognostic factors, the recurrence risk approaches and in some cases surpasses the risk of recurrence documented for patients with one to three positive lymph nodes. numerous retrospective series have reported the outcome and patterns of failure for post-mastectomy patients treated without radiation. many of these series have analyzed several high risk factors which were predictive of loco-regional recurrence wherein the role of adjuvant post-mastectomy radiation can be considered. some authors have used combinations of prognostic factors, such as age, tumour size, grade, receptor status, her2neu status and lympho-vascular space invasion to define subgroups with more specific risks of loco-regional recurrence than single factors alone. the current trial hypothesizes that "post-mastectomy radiation in high risk, node negative early breast cancer patients decreases rates of loco-regional recurrence and improves disease free survival" and propose to address the question in randomized setting.


Eligibility criteria:
inclusion criteria: * women with unilateral pt1,2n0m0 breast cancer or multifocal breast cancer if largest discrete tumour at least 2cm or if the tumour area comprises multiple small adjacent foci of invasive carcinoma then overall maximum dimension taken. this must be greater than 2cm. * upfront total mastectomy (with minimum 1 mm margin clear of invasive cancer or dcis) and axillary staging procedure (clearance, sampling or snb) * t2 tumors with one risk factor or t1 tumors with any of the following two high risk factors such as presence of high grade, lymphovascular invasion, er/pr negative, her2 positivity, age \< 35 years. * fit to receive adjuvant radiation +/- chemotherapy (if indicated) +/- hormonal therapy (if indicated) * written, informed consent exclusion criteria: * any ptis/3/4, m1 patients * patients who have any pathologically involved axillary nodes (micro-metastasis may be allowed) * patients who have undergone neoadjuvant systemic therapy. * previous or concurrent malignancy other than non melanomatous skin cancer and carcinoma in situ of the cervix * pregnancy * bilateral breast cancer * not fit for surgery, radiotherapy or adjuvant systemic therapy * unable or unwilling to give informed consent

Keywords: post-mastectomy radiation node negative early breast cancer
evaluation of the effect of fluvastatin 40 mg (b.i.d.) in the prevention of the development of vasculopathy of the graft in de novo renal transplant patients transplant

Conditions: Graft Vasculopathy

Summary: principal objective is to investigate if the treatment with fluvastatin can prevent the progression of vascular graft disease in de novo renal transplant patients.


Eligibility criteria:
inclusion criteria: * patients where the investigator expects to prescribe cyclosporine, mycophenolate mofetil and corticosteroids as base immunosuppressive therapy, regardless of their participation in the study. * man or woman aged from 17 to 70 years. * patients that receive a first or second renal transplant from a non-living donor * patients where allograft biopsies may be performed. * patients receiving an identical or compatible abo graft. * patients willing to give their written informed consent to all study issues. * women with child-bearing potential should use a medically proven contraceptive method during the study. * patients able to meet all study requirements. exclusion criteria: * patients with pre-transplant cholesterol levels above 240 mg/dl (6.2 mmol/l). * positive cross-match of t cells or abo incompatibility with the donor. * recipients of multiorgan transplant. * patients with diabetes mellitus. * hiv seropositive or with surface antigen of hepatitis b . * kidney from a donor aged over 65 years. * last panel of reactive antibody (pra) above 50%. * women who plan to get pregnant within 12 months, or who are pregnant and/or nursing. * patients with a history of cancer in the previous 5 years, except for patients successfully treated with localized carcinoma of squamous or basal cells of the skin, or cervix cancer in situ treated adequately. * patients receiving an investigational drug in the 30 days prior to the transplant and/or who will receive an investigational/non-registered drug during the study, except for the use of erythropoietin-stimulating products * patients with myocardial infarction within the 6 months prior to the transplant, uncontrollable cardiac arrhythmia or another severe or unstable medical condition probably affecting the safety of the patient or the study objectives. * patients with alcohol dependence or drug abuse not solved, or signs of organic lesion caused by alcohol, mental dysfunction or other factors limiting their ability to fully cooperate with the study. * patients where it is planned to perform an induction treatment with preparations containing antilymphocyte antibodies (alg, atg or okt-3). * patients scheduled to receive cyclosporine i.v. for over 48 hours. * patients with liver dysfunction (alt or ast values or total bilirubin 2 times above the upper limit of the normal ranges of the laboratory values). * other protocol-defined inclusion/exclusion criteria may apply

Keywords: renal transplantation fluvastatin
the effects of spinal mobilizations on neck pain and sympathetic nervous system activity in people with neck pain

Conditions: Neck Pain

Summary: this study investigates the effects of spinal mobilizations on neck symptoms and sympathetic nervous system activity in people with neck pain.


Eligibility criteria:
inclusion criteria: * primary complaint of neck pain * non-traumatic history of onset * pain has a clear mechanical aggravating and easing positions or movements * limited range of motion * local provocation tests produce recognisable symptoms * a positive expectation that mobilisations will help exclusion criteria: * no neurological deficit * no signs of central hyperexcitability * referral to other health professional to exclude red flags not required