Kornimate/medical-research-clean huggingface dataset:
assessment of intra-operative and early post-operative lasik complications

Conditions: Cornea

Summary: to discuss the prevalence of intra-operative and early post-operative complications of lasik among individuals who underwent lasik procedure and review the symptoms, findings, and management options.

in recent years, a number of possible surgical procedures in ophthalmology has offered patients an alternative to spectacles or contact lenses. several laser and non-laser refractive surgical procedures have been used to modify the shape of the cornea and correct myopia, hyperopia, astigmatism, and presbyopia. introduction of the excimer laser to reshape the cornea has resulted in remarkable developments in the correction of refractive errors. combined with other advanced ophthalmic instruments, laser refractive eye surgery has resulted in a substantial increase in the safety, efficacy, and predictability of surgical outcomes. refractive surgery has enabled individuals to enter occupations they were previously precluded from due to their vision.laser in situ keratomileusis (lasik) surgery is one of the most common surgeries performed worldwide to correct refractive errors and reduce dependence on eyeglasses or contact lenses. in addition, patient satisfaction following lasik is commonly reported as high and studies of the visual and refractive outcome of lasik for the treatment of myopia and astigmatism have reported great success. lasik, compared to photorefractive keratectomy (prk), has low postoperative discomfort, early visual rehabilitation and decreased postoperative haze. lasik involves an additional procedure of creating a corneal flap. this may result in complications related to the flap, interface and underlying stromal bed. the common flap-related complications include thin flap, button holing, free caps, flap dislocation, torn flap, incomplete cut, and flap striae. the interface complications of diffuse lamellar keratitis, epithelial ingrowth and microbial keratitis are potentially sight threatening. after lasik, there is a long period of sensory denervation leading to the complication of dry eyes. the refractive complications include under-correction, over-correction, regression, irregular astigmatism, and visual aberrations.

Eligibility criteria:
inclusion criteria: * individuals who are scheduled for lasik surgery exclusion criteria: * history of previous ocular surgery, and inadequate follow up.

Keywords: lasik complications
cryoanalgesia for pain management after pectus excavatum repair

Conditions: Pectus Excavatum

Summary: cryoanalgesia for pain management after pectus excavatum repair. copper study (cryoanalgesiafor pain management after pectus excavatum repair): a randomized controlled trial. determine if, in patients more than 12 years of age having cryoanalgesia for pectus excavatum repair analgesia improves the standard of care (epidural analgesia) in term of pain relief and return to normal life 2 weeks after surgery. randomized active controlled, parallel group, single-centre, trial (category iib medical device). 88 patients aged more than 12 years of age scheduled for pectus excavatum repair. after randomization, patients will receive intraoperative cryo-analgesia or standard of care (epidural-analgesia). pedsqlscale (23 items) two weeks after surgery. patients will be followed for 6 months after surgery to determine time until return to normal life and occurrence of any complication related to the use of cryo-analgesia. numeric rating scale (nrs), cali9, yapfaq will be measured at fixed times to determine pain intensity and limitations due to pain. risk factors for prolonged pain and time needed until achieving discharge criteria from hospital will be reported.


Eligibility criteria:
inclusion criteria: * patients undergoing pectus excavatum repair with nuss technique * aged 12 years or above12 * informed consent signed for cryoanalgesia exclusion criteria: - age of 11 years or below * refuse to receive cryoanalgesia or epidural catheter as primary pain relief * any contraindication to cryoanalgesia * difficult follow-up for geographical reasons and/or impossibility by the patient to understand how to perform self-measurements
urine bag usage versus chest drain clamping after lung resection surgeries

Conditions: Pneumothorax and Air Leak; Pneumothorax; Pleura Injury; Pleural Effusion

Summary: investigators will compare two different approaches of postoperative drainage after the standard water-seal drain has been used efficiently; one is by using urine bag and check it get blown by the leaked air, two is by using clamping of the water seal drain. investigators will compare them depending on several factors such as; cost effectiveness, hospital stay, duration of putting the drain and more, reinsertion of the chest tube and others.


Eligibility criteria:
inclusion criteria: * post lung resection patients (via uniportal vats only) * over the age of 18 * indicated chest tube exclusion criteria: * under the age of 18
pace call: weight loss study for childhood leukemia survivors

Conditions: Acute Lymphoblastic Leukemia; Cancer; Obesity

Summary: uc san diego researchers conducted a study to develop and evaluate an internet and text message based weight loss study for childhood acute lymphoblastic leukemia (all) survivors. we hypothesized that those study participants randomized to the intervention will demonstrate greater reduction in bmi-z score as compared to the control group.

the pace call or fit4life study, sponsored by the american cancer society , was a 4-year research project aimed at developing and testing the efficacy of a web \& cell phone based weight loss program. the purpose of the intervention was to promote weight loss and management and improve physical activity, diet and sedentary behaviors among preadolescent and adolescent youth (7-18) who are survivors of childhood all (defined as being off therapy for at least 2 years without disease relapse). fit4life was based on and adapted from notable prior successful adolescent weight control interventions, and physical activity and diet behavioral promotion interventions in the preadolescent and adolescent age group. particular sensitivity to issues experienced by cancer survivors and their families were incorporated into this newly developed intervention based on systematic cancer survivor input and feedback as well as mentor/collaborator input regarding cancer survivor research.

Eligibility criteria:
inclusion criteria: * 7 - 18 years old * survived childhood acute lymphoblastic leukemia (defined as being off treatment for at least 2 years) * greater than or equal to 85th percentile bmi-for-age and gender) * read and speak english * have a parent that reads and speaks english or spanish * willingness to attend assessments * access to the internet exclusion criteria: * any comorbidities of obesity that require immediate sub-specialist referral including pseudotumor cerebri, sleep apnea, and obesity hypoventilation syndrome * any subject with a known disease of the liver, pancreas or small intestine that would adversely effect digestion or absorption of nutrients * any pulmonary, cardiovascular, orthopedic, or musculoskeletal problem that would limit ability to adhere to moderate-level physical activity recommendations * have a history of substance abuse or other psychiatric disorder that would impair compliance with the study protocol * are using any medications which alter body weight * are currently enrolled in another weight loss program * in foster care

Keywords: obesity text messages internet cancer overweight
jaw clenching on anaerobic ability and ventilatory flows

Conditions: Mouth Breathing

Summary: the latest findings on the ergogenic effects of a dentistry-design, bite-aligning mouthpiece require additional research to assess its impact on anaerobic ability and ventilatory parameters. this study was aimed at determining the ergogenic acute effects of wearing a custom-made mouthpiece on oral airflow dynamics, wingate test performance parameters.

the objectives of this study are to investigate the acute effects of a customized, bite-aligning mouthpiece on the different parameters assessed during a wingate test, as compared to clenching the jaw without a mouthpiece, in a physically-active, male population. the study also investigate the influence of wearing a mouthpiece on non-forced and forced airflow dynamics, as compared to open mouth and a jaw clenching without mouthpiece. mouthpieces are made using a new scanning method that simplified the fitting process and lowered its cost. a nonrandomized study was designed to compare the effect of the occlusion condition on the anaerobic power and airflow dynamics. conditions of wearing or not wearing mouthguard (mouthg and no-mouthg, respectively) are randomly distributed in all tests. each subject participate in three sessions. the first session is used to obtain informed consent assess anthropometric measurements and to scan the subject's mouth structure. in the second session, subjects are familiarized with the test protocols via a learning session that included demonstration of wingate test and the airflow dynamics measurements. subjects also perform the airflow tests and the first wingate test trial. in the third session, subjects perform the second wingate test trial. conditions are randomly distributed in all tests. wingate test trials were separated by three days and subjects were not allowed to perform intensive training workloads.

Eligibility criteria:
inclusion criteria: * healthy physical active males exclusion criteria: * acute or chronic injury that caused pain during testing procedures * temporomandibular joint disorders

Keywords: mouthguard ventilation anaerobic power ergogenic effects
genyal study to childhood obesity prevention

Conditions: Childhood Onset Obesity

Summary: obesity is a multifactorial, complex, chronic disease of special concern. it is originated as an interaction between genetic predisposition and environmental factors. thus, knowledge of gene-diet interactions is especially important. however, most studies analyzing the efficacy of diet on body weight have not considered the genetic variability among the population. childhood and adolescence are critical periods in the development of obesity. this is because, on one hand, during infancy dietary patterns are being implemented. moreover, it has been described that around the age of 6 it occurs the adiposity rebound, which consists in the increase in body mass index (bmi) that occurs after reaching a lowest point in infancy. it is believed that an early adiposity rebound is associated with a higher risk of developing obesity in the following years. the prevalence of overweight and obese children is increasing every year. specifically, according to the world health organization (who) the number of overweight or obese children aged 0 to 5 years, increased from 32 million globally in 1990 to 41 million in 2016. regarding spanish children, they are amongst the highest levels of overweight and obesity in europe. precisely, in 2015 the spanish agency for consumer affairs, food safety and nutrition reported 23.2 % overweight and 18.1 % obese spanish children, according to the aladino study. considering the previous elaboration, we hypothesized that an early identification of snps associated with obesity will improve the strategies applied for its prevention. moreover, an adequate nutritional counseling and a healthy lifestyle implementation during childhood will contribute to a higher quality of life in the adulthood. thus, schools from the madrid community agreeing to participate in the study will be randomly assigned to either control or intervention groups. then, an initial evaluation where 26 snps associated with obesity and its related comorbidities will be carried out in all children involved in the study, in addition to anthropometric, blood pressure measurements, and physical activity and dietary patterns evaluation. then, each group will be divided in two according to the genetic risk (high vs low) for presenting obesity and its related comorbidities. the initial evaluation was performed on all children at 1st and 2nd grades and it is going to be followed by 3 monitoring actions in the following years where the progression of anthropometric measurements and dietary habits are going to be studied. besides, the intervention schools are going to receive healthy actions along the study aimed to reduce the risk of developing obesity.


Eligibility criteria:
inclusion criteria: children at 1st and 2nd grades from schools of the madrid community that have accepted to participate in the study, whose parents have approved and signed the informed consent.

Keywords: schoolchildren overweight obesity polymorphisms genetics nutritional counseling healthy strategies
sustained lung inflation and pulmonary mechanics in preterm infant

Conditions: Preterm Birth; Respiratory Distress Syndrome; Lung Diseases

Summary: lung protection should start in the delivery room where, from the first breaths, the preterm infant can be helped to clear the lung fluid and to recruit alveolar spaces and establish the functional residual capacity (frc). sustained lung inflation (sli) applied at birth in the delivery room has been demonstrated to lead to clearance of lung fluid and achievement of a precocious functional residual capacity (frc) both in animal and human studies. sli associated to an adequate positive end expiratory pressure (peep) may help the efficacy of the respiratory effort in lung of preterm infants at risk for respiratory distress syndrome (rds) and reduce need of mechanical ventilation (mv). further studies are required to evaluate the clinical utility of this maneuver. the ability to monitor what happens to the lungs while applying different recruitment maneuvers in preterm infants would allow the definition of a procedure that allows optimal assistance to improve the frc. one promising approach is provided by the forced oscillation technique (fot). during forced oscillations, a small amplitude sinusoidal pressure stimulus is applied to the airway opening and the mechanical response of the respiratory system is studied by means of the total respiratory input impedance (zin). zin is a complex number that can be expressed as real part, called resistance (rrs), and imaginary part, called reactance (xrs). particularly, it has been recently shown that xrs measured at 5 hz is very sensible to changes in the mechanics of lung periphery and provides accurate information about lung volume recruitment and derecruitment. the main purpose of this work is to apply fot to the assessment of lung function in newborns submitted to sli at birth. the investigators hypothesized that the application in the delivery room of the sli in the preterm infant is effective in achieving a greater frc and therefore a greater value of xrs compared to a control group not treated with the sli.


Eligibility criteria:
inclusion criteria: * gestational age (ga) at least 25 weeks but less than 36 completed weeks by best obstetrical estimate exclusion criteria: * refusal of antenatal informed consent * known major anomalies, pulmonary hypoplasia * severe perinatal suffering

Keywords: respiratory distress syndrome, newborn delivery room resuscitation premature birth infant, newborn respiration artificial
a study of mabthera (rituximab) plus standard chemotherapy in patients with previously untreated mantle cell lymphoma.

Conditions: Mantle Cell Lymphoma

Summary: this single arm study will evaluate the benefit of adding mabthera to standard induction chemotherapy in patients with newly diagnosed mantle cell lymphoma. the safety and tolerability of a mabthera-containing first line regimen will also be assessed. all patients will receive mabthera (375mg/m2 iv) every 3 weeks for 8 cycles, in combination with standard chemotherapy. the anticipated time on study treatment is 3-12 months, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * histologically-proven mantle cell lymphoma; * previously untreated disease at stage ii, iii and iv, requiring therapy. exclusion criteria: * known hypersensitivity reaction to rituximab, or known anti-murine antibody reactivity or known hypersensitivity to murine antibodies; * active malignancy other than mantle cell lymphoma within 5 years of start of study, with the exception of resected basal cell cancer, squamous cell cancer of the skin, or in situ cancer of the cervix; * serious disorders interfering with full standard dosing chemotherapy; * stage i disease.
epidemiology of roller hockey related injuries.

Conditions: Sports Injury

Summary: roller hockey is a sport played on a 40\*20 metres rink characterized by combined periods of high intensity and short breaks, there´s a lack of epidemiological studies in this field. in line with the well-established model of sports injury prevention research proffered by van mechelen, the first stage in this process is establishing the extent of the problem i.e. injury incidence, severity and burden. through an online survey filled by semiprofessional athletes, it is posible to obtain all this important information. this way, it will be possible to fulfill a gap in the literature and take action in the near future in order to reduce the prevalence of injuries in this sport.

a retrospective study was performed in male roller hockey players. 275 players will be recruited. data of all injury along a whole season will be collected. patients' information, including age, number of years playing, skill level and injured body part, will be analysed.

Eligibility criteria:
inclusion criteria: being a roller hockey player, play for one of the teams who participated in the 2020-2021 season third division league (ok liga bronce). play in at least one match in the season. - exclusion criteria: being unable to understand the questionaire, do not accept on participating in the study. -

Keywords: prevalence multidirectional sport injury prevention athletic injuries
effectiveness of a low carbohydrate diet versus a high carbohydrate diet in promoting weight loss and improved health

Conditions: Obesity; Hypertension

Summary: this study will examine the effects of a low carbohydrate diet versus a high carbohydrate diet on weight loss.

the number of overweight and obese americans has increased significantly in recent years. there are now many different diet plans being promoted by doctors and the media. the atkins diet, a low carbohydrate nutritional plan, is especially popular; its advocates claim that following the diet will result in long-term weight loss with no negative effects. another diet, called the dietary approaches to stop hypertension (dash) diet, is a high carbohydrate diet designed to help treat and prevent high blood pressure. however, more thorough investigation of these claims is needed. this study will compare the short- and long-term effects of the atkins diet to the (dash) diet. this trial will enroll overweight and obese participants. this study will last 30 months and will comprise two phases. participants will be randomly assigned to either the atkins or dash diet for 30 months. during phase 1, all participants will undergo 6 months of weekly group therapy to encourage weight loss. phase 2 is a weight loss maintenance phase. during phase 2, participants will have monthly meetings with a therapist for weight loss support. study visits will occur at study entry and at months 3 and 30. at each study visit, weight measurements, blood and urine collection, and x-rays will occur to determine participants' weight loss, cardiovascular health, kidney function, and bone density.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) of 27 to 50 * fasting glucose less than 126 mg/dl * total fasting cholesterol less than 260 mg/dl * total fasting triglycerides less than 400 mg/dl * permission of primary care provider to participate in the study * normal liver and kidney function * willing to modify diet and other health behaviors * willing to use an acceptable method of contraception for the duration of the study exclusion criteria: * any medical condition that may make weight loss medically inadvisable * weigh more than 400 lbs * history of kidney failure * current use of more than 3 blood pressure medications * change in blood pressure medications within 3 months prior to study entry * diagnosis of cardiovascular disease within 6 months prior to study entry * cancer diagnosis within 2 years of study entry. participants with basal cell skin cancer are not excluded. * history of psychiatric hospitalization within 2 years prior to study entry * consumption of more than three alcoholic drinks a day * type i or ii diabetes * current use of hypolipidemics, antipsychotics, hypoglycemics, glucocorticoids, or thyroid medication * plan to move during study * current participation in another clinical trial * pregnancy or breastfeeding

Keywords: diet carbohydrates weight loss
infertility markers in serum, urine, and follicular fluid

Conditions: Infertility

Summary: this study is only collecting specimens from current patients of penn fertility care. the purpose of this investigation is to assess if markers of oxidative stress that are known to be associated with other medical conditions can be detected in women undergoing infertility treatment and normal women of similar age. oxidative stress may affect a woman's eggs or the follicular cells that surround and nurture them. other markers of to be investigated include markers of cellular aging and dna structural changes. presence of these markers will be compared in blood and urine samples taken during infertility treatment, and follicular fluid at the time of ivf (if applicable).


Eligibility criteria:
inclusion criteria: * women aged 18-50 * infertility patients only: 1. women undergoing infertility treatment (with or without in-vitro fertilization) at the university of pennsylvania's penn fertility care 2. verified infertility diagnosis of any of the following: * endometriosis (minimal or mild) * endometriosis (moderate or severe) * tubal factor * hypogonadotrophic hypogonadism * polycystic ovary syndrome * diminished ovarian reserve * male factor * unexplained * healthy normal volunteers only: 1. not undergoing infertility treatment 2. not using hormonal contraception exclusion criteria: * currently pregnant or breastfeeding * post-menopausal * concurrent participation in investigational trial * other health problems which, in the opinion of the investigator, may affect participation

Keywords: infertility oxidative stress