Kornimate/medical-research-clean huggingface dataset:
a comparative study of the efficacy in plaque removal of two manual toothbrushes

Conditions: Tooth Caries; Dental Plaque

Summary: objective: to compare the efficacy of curaprox® cs 5460 ultra soft and oral-b® indicator plus toothbrushes in dental plaque removal. methods: 50 adult participants will be included in the sample. for a period of 24 hours (at two different times), they will be instructed to stop oral hygiene. during the final 4 hours, the interruption of consumption of foods and liquids will be recommended, and in smokers' case, the use of cigarettes. in two clinical visits (t0 and t1), volunteers will be asked to brush their teeth for 1 minute with curaprox® (cs 5460 ultra soft) e oral-b® (indicator plus) toothbrushes. disclosure will be performed prior to and after brushing and the presence of plaque on the tooth surfaces will be evaluated. turesky modified quigley hein plaque index will be used for the plaque record. for statistical analysis, paired t tests will be performed to compare the effectiveness of toothbrushes and correlation test to assess whether the fact that the patient was aware of the toothbrush that will be used influenced in their performance.

for the study, 50 patients, between 18 and 55 years of age, of both sexes and healthy will be selected. for the study performance, volunteers will be instructed to stop their brushing for 23 to 25 hours before the first clinical visit. in addition, they will be also instructed to stop eating (solid foods and liquids) and to stop the use of cigarettes, if smoker, for 4 hours before evaluation. prior to the study, a pilot study will be conducted at the university hospital of brasília for the researcher calibration using the turesky modified quigley hein plaque index, following the predetermined protocol. a double-blind crossover study will be designed in which each volunteer will test two different models of toothbrushes. prior to the beginning of the study, the brushes handle will be hidden with tape in a way that it will be not possible to see the toothbrush trademark. during the two visits, both brushes will be placed on the workbench and in the absence of the researcher, the participant will select one of the brushes. in the following visit, the same procedure will be performed and the participant will use the second brush. a period of washout of at least one week between the the first visit and the second visit will be done to obtain non-interference between results. no brush restriction will be imposed for the participant during this period.

Eligibility criteria:
inclusion criteria: * good oral health * at least, 24 health teeth exclusion criteria: * those with any limitations that make it difficult for the dental examination or the performance of brushing, which use removable prostheses, orthodontic appliances, and/or that have malocclusions, and the presence of a gingival recess equal to or greater than 2mm
a phase i clinical trial of syb l-0501 in combination with rituximab to patients with aggressive b-cell non-hodgkin's lymphoma

Conditions: Non-Hodgkin's Lymphoma; Diffuse Large B-Cell Lymphoma; Mantle Cell Lymphoma; Follicular Lymphoma

Summary: the purpose of this study is to assess the safety of syb l-0501 in combination with rituximab to patients with aggressive b-cell non-hodgkin's lymphoma, and to explore the recommended dose for the phase ii clinical trial.


Eligibility criteria:
inclusion criteria: aggressive b-cell non-hodgkin's lymphoma patients with prior therapy who satisfy the conditions listed below. no restrictions regarding gender. * patients with the following histologically confirmed cd20(+) b-cell non-hodgkin's lymphoma: 1. diffuse large b-cell lymphoma 2. mantle cell lymphoma 3. transformed lymphoma 4. follicular lymphoma (grade 3) * fail to cr in prior chemotherapy, or relapse following cr or recurrence following pr. * patients who are judged to carry no effect from the prior therapy (cancer chemotherapy, antibody therapy and radiation/ radiotherapy. * patients aged from 20 to 75 years at the time informed consent is obtained * patients with adequately maintained organ functions (e.g., bone marrow, heart, lung, liver, and kidney functions) * patients who can be hospitalized during the first cycle * patients capable of personally giving voluntary informed consent in writing to participate in the study exclusion criteria: patients who meet any of the following criteria will be excluded. * patients with serious complications (hepatic or renal failure) * patients with complications or medical history of serious cardiac disease (e.g., myocardial infarction, ischemic heart disease) * patients with serious gastrointestinal symptoms (e.g., severe nausea, vomiting, or diarrhea) * patients positive for hbs antigen, hcv antibody, or hiv antibody * patients who received other investigational drug or unapproved medication within 3 months before registration in this study * patients who had history of hematopoietic stem cell transplantation or radioimmunotherapy * patients who are pregnant, of childbearing potential, or lactating * patients, whether male or female, who do not agree to contraception * patients otherwise judged by investigator or sub investigator to be unsuitable

Keywords: non-hodgkin's lymphoma diffuse large b-cell lymphoma mantle cell lymphoma transformed lymphoma, transformed to diffuse large b-cell lymphoma follicular lymphoma
bilateral uterine artery ligation after intrapartum or postpartum hemorrhage on ovarian reserve markers and pregnancy outcome

Conditions: Bilateral Uterine Artery Ligation; Intrapartum or Postpartum Hemorrhage; Ovarian Reserve Markers; Pregnancy Outcome

Summary: the aim of this study is to assess the possible negative effects of uterine artery ligation on ovarian reserve markers and subsequent pregnancy outcomes

one of the most common surgical methods for preserving fertility is uterine artery ligation. it is simple to do and effective at reducing postpartum hemorrhage after delivery . additionally, it is rather safe and permits future childbearing for the patients.

Eligibility criteria:
inclusion criteria: * 120 females aged from 20 to 35 years old * with postpartum hemorrhage or intrapartum hemorrhage after cesarean section * did not respond to medical therapy * performed successful bilateral uterine artery ligation for hemorrhage management. exclusion criteria: * the presence of male factor or tubal factor. * hypertension, autoimmune disease, morbid obesity, absence of lactation diabetes millets, vascular disease, smoking or the use of alcohol. * the presence of additional surgery or medical disease. * detection of a uterine anomaly, history of intrauterine growth restriction in previous pregnancies. * usage of a hormonal therapy through the research.
leukemia cell cultures for research of new anti-cancer therapies

Conditions: Acute Leukaemia

Summary: the main objective of this project is not only a better understanding of the human leukemic disease but also to find new anti-leukemic or improve existing ones. this study has, the following aims: * to analyze the genetic and epigenetic regulation of the retinoic acid induced cascade which leads to the expression of trail in blood cells of patients with acute leukemia. this study will be complemented by the analysis of global gene expression (dna chips) and of the dna methylation state, and by chromatin immunoprecipitation experiences. * to determine the efficiency of inhibitors of enzymes responsible for the modification of chromatin (existing and new developments within the european consortium epitron coordinated by dr gronemeyer) as inducers of differentiation and / or apoptosis of leukemic blasts. * to explore ikaros genic and functional abnormalities (genomic deletions, mutations, abnormal transcripts and proteins) in acute leukemia. the aim is to determine if these abnormalities may play a prognosis role.


Eligibility criteria:
inclusion criteria: * patients with suspected de novo or secondary or relapsed acute leukemia, requiring complementary blood test and bone marrow analysis * patients older or equal than 28 days * informed consent signed exclusion criteria: * pregnancy * breastfeeding

Keywords: leukaemia blood and marrow cells culture cell growth cell differentiation
proprioception in the improvement of sports performance in long jumpers.

Conditions: Proprioceptive Disorders

Summary: introduction: in jumping sports the tendinopathies of patellar and achilles tendon are very frequent. sports performance is the action that optimizes the relationship between physical abilities and the exercise to be performed. good proprioceptive work favors the correct execution of the technique in jumping sports. aim: to evaluate the effectiveness of the lower limb proprioception exercise in the increase of sports performance, in adults and federated long jumpers study design: randomized single-blind multicenter study, with follow-up period. methods: the 139 subjects included in the study will be randomly assigned to the two study groups: experimental (proprioception protocol) and control (non-intervention group). the intervention will be carried out for 4 weeks, with two weekly sessions, lasting 25 minutes. three evaluations were carried out (baseline, post-intervention and follow-up). the study variables will be: proprioception (evaluated by the romberg test and the sebt), and sports performance (evaluated with vertical, horizontal jump and competition simulation tests). the analysis of normality will be carried out by the kolmogorov smirnof test and in the case of homogeneity of the groups, through the t-student test of related measures and an anova of repeated means, we will calculate the difference between the different evaluations and the effect intra and intersubject. expected results. to observe improvement in sports performance, once the proprioceptive exercises have been carried out.


Eligibility criteria:
inclusion criteria: * jumping athletes in length * female * with an age range of 18 to 35 years * currently participate in regional and / or national competitions. exclusion criteria: * not signed the informed consent document * practice another sport discipline * have some type of medical diagnosis of injury to the lower limb at the time of study.

Keywords: proprioception sports performance long jump physiotherapy randomized clinical trial.
the role of circ0014614 in the formation and development of et

Conditions: Primary Thrombocytosis

Summary: research on the role of circ0014614 in the formation and development of et

in recent years, tumor niche involved in the development of myeloproliferative disease（mpn）, which is remodelled by stem progenitor cells driving gene mutation, has attracted attention, but the reason and mechanism of remodelling microenvironment by mutated hematopoietic stem cells（ hscs） are poorly understood. our previous studies have shown that there is an obstacle in the transport of extracellular vesicles circ0014614 from meps in et patients, which is enriched in the cytoplasm of megakaryocyte-erythroid progenitor（meps）, causing abnormal proliferation and reduced apoptosis of meps. the amplified meps affect the ossification of mesenchymal stem cells（mcss）. based on this, we propose a hypothesis that circ0014614 may cause abnormal amplification of meps, reshape niche, induce ossification of mcss, and abnormal amplification of osteoblasts（obcs） through a certain pathway, promoting the formation and development of et. this study will expand the collection of bone marrow samples from essential thrombocytosis（et） patients, detect the differences in circ0014614 levels in peripheral blood and bone marrow before and after treatment, and predict its downstream microrna and mrna through bioinformatics analysis to speculate its role in the occurrence and development of the disease. in recent years, tumor niche involved in the development of mpn, which is remodelled by stem progenitor cells driving gene mutation, has attracted attention, but the reason and mechanism of remodelling microenvironment by mutated hscs are poorly understood. our previous research has shown that there is an obstacle in the transport of extracellular vesicles circ0014614 from meps in et patients, which is enriched in the cytoplasm of meps, causing abnormal proliferation and reduced apoptosis of meps. the amplified meps affect the ossification of mcss. based on this, we propose a hypothesis that circ0014614 may cause abnormal amplification of meps, reshape niche, induce ossification of mcss, and abnormal amplification of obcs through a certain pathway, promoting the formation and development of et. this study will expand the collection of bone marrow samples from et patients, detect the differences in circ0014614 levels in peripheral blood and bone marrow before and after treatment, and predict its downstream microrna and mrna through bioinformatics analysis to speculate its role in the occurrence and development of the disease.

Eligibility criteria:
inclusion criteria: 1. according to the classification and diagnostic criteria of hematological myeloid tumors by who 2016, patients diagnosed as et are standardized 2. voluntary signing of informed consent form 3. age ≥ 18 years old, regardless of gender 4. no pregnancy plan during treatment exclusion criteria: 1.the researcher judged that it was not suitable to participate in this study
comparison of activa bioactive versus compomer in restoring dental decay in primary molar teeth

Conditions: Dental Caries in Children

Summary: a clinical trial to evaluate a filling material (activa) and compare it to a traditional filling material (compomer) to restore decayed deciduous teeth in children

a tooth decay in deciduous teeth has to be restored with proper filling material. activa™ bioactive is a new filling material which has the ability to release and recharge fluoride in the oral cavity which is important for preventing further tooth decay. in this study we will compare this new filling material with compomer (the traditional control filling material) by restoring decayed deciduous molars with one of the mentioned filling materials. both filling materials have no reported adverse effect and used regularly in the dental practice. the treatment procedure is performed in healthy children from both genders with decayed deciduous molars aged between 5 to 10 years by one operator in the dental chair under local anesthesia in the department of pediatric dentistry and special care, ghent university hospital, ghent, belgium. at least 35 teeth is needed to demonstrate an effect. each material is placed randomly based on randomization done by the computer. each participant will receive both types of treatments, one type on each side of the mouth. the participants will come back each six months to check the success of each treatment group by two trained dentists other than the operator. and to check whether the control group performs similar, better or worse than the control group. the duration of treatment procedure of both treatment groups is recorded and compared to check if one filling material takes less time than the other to placed in the oral cavity.

Eligibility criteria:
inclusion criteria: * healthy children with american society of anesthesiologists (asa) i score from both gender aged between three and ten years * vital decayed deciduous molar with proximal enamel/dentine caries * at least one decayed tooth on each side of the mouth (split mouth) * pt is treatable in the dental chair * parents agreed to participate in the study and signed the informed consent exclusion criteria: * patients with medical conditions or systemic disease * anxious or uncooperative patients who are not treatable in the dental chair * any symptoms like: pain, swelling, abscess or fistula. * extensive caries, dental developmental disturbance, pathological mobility, pulp exposure or indication for pulp therapy * patients with one decayed tooth in the whole mouth (not split mouth)

Keywords: dental caries class ii primary molar restorative material bioactive material compomer activa bioactive ryge criteria
premenstrual symptoms treatment comparing between oral contraceptives containing desogestrel and drospirenone

Conditions: Premenstrual Syndrome

Summary: the purpose of this study is to determine whether low-dose combine oral contraceptives (coc) containing desogestrel 150 mg and drospirenone 3 mg are effective in the treatment of premenstrual symptoms.

premenstrual syndrome is commonly reported 20-90 percent in reproductive-aged women. only a small percentage of women (2 to 5%) have significant premenstrual symptoms defined as premenstrual dysphoric disorder (pmdd). the exact symptoms and their intensity vary from woman to woman and even from cycle to cycle.while exact causes of pms are not fully understood,current thinking suspects that fluctuation of endogenous sex hormones are relevant. the standard 21/7 design may induce menstrual-related symptoms including headache, mood swings, abdominal cramping, bloating, and breast tenderness that increase during the last week of active pills extending along the 7-day hormone free interval(hfi). the decline in endogenous estradiol levels during hfi may be responsible for the estrogen-withdrawal symptoms. while a new coc with drospirenone introduced in 24/4 design has been shown in clinical trials to significantly improve the symptoms of pms, there has been questioned about efficacy of the other kind of coc which has optimal properties, for example, good-control cycles extend to the similar 24/4 regimen.

Eligibility criteria:
inclusion criteria: * age 18-35years * regular menses, i:21-35 days * willingness to take coc for 6 months * no history of coc in last 6 months * no history of injected contraception in last 6 months * history of implant contraception need to have regular menses 3 cycles * history of miscarriage need to have regular menses 3 cycles exclusion criteria: * pregnant or suspected pregnant * breast feeding * smoking * contraindication of who 2,3 and 4 * pmdd

Keywords: pms low-dose combine contraceptives pills coc
multi-omics study on gut microbiota in critical ill patients after cardiopulmonary bypass

Conditions: Sepsis; Cardiopulmonary Bypass

Summary: using metagenomics as well as metabolomics, the variation of the gut microbiota and host metabolite profiles of patient after undergoing cpb were explored.

this protocol is designed as a prospective observational case-control study in patients who underwent cardiopulmonary bypass (cpb) due to cardiac surgery. 30 healthy persons were selected as control group. the case group included patients admitted to intensive care unit (icu) after cardiac surgery and extracorporeal circulation which is performed by the department of cardiac surgery of peking union medical college hospital. the patients enrolled should be divided into two groups according to their primary outcomes: one grouped fever and/or hemodynamic instability after cardiopulmonary bypass and the other grouped normothermia and normal hemodynamic during 48 hours after surgery(cause an infection manifested \>48 hours after admission was defined as hospital acquired. ). sample collection was terminated when both groups received 30 cases. these 60 cases would regard as the case group. additionally, all the cpb patients we observed will be divided into survivors and non-survivors based on the 28-day survival. feces and blood samples will be obtained at certain time points（initial sampling at least one day before the surgery, repeat sampling within 24-48 hours after cpb）. the fecal samples analysis will apply metagenomics and the feces and blood samples will be analyzed using untargeted metabolomics method. in this study, the stratification of gut microbial communities in patients underwent extracorporeal circulation were explored and analysed the variation of metabolite in patients's plasma and fecal samples. predictive bio-markers and possible pathogenesis of fever and/or hemodynamic instability after cpb will be also provided by clinical outcomes analysis combined with multi-omics study.

Eligibility criteria:
inclusion criteria: * patients will be admitted to icu between 18 and 85 years of age who will undergo extracorporeal circulation during cardiac surgery and provided written informed consent will be enrolled as candidates of case group. * healthy volunteers will be enrolled as control group. exclusion criteria: * patients had a fever before surgery, regardless of the etiological evidence of infection; * had anti-infective treatment before surgery; * had gastrointestinal surgery which left the digestive system dysfunctional; * had a history of cpb in 6 month; * reject or abandon icu therapeutic intervention.

Keywords: cardiopulmonary bypass gastrointestinal microbiome thoracic surgery metagenomics metabolomics sepsis
the effect of tranexamic acid on postoperative blood loss and coagulation in patients with preoperative anemia undergoing off-pump coronary artery bypass graft; double blind randomized control study

Conditions: Coronary Artery Occlusive Disease

Summary: the effect of tranexamic acid on postoperative blood loss and coagulation in patients with preoperative anemia undergoing off-pump coronary artery bypass graft; double blind randomized control study.


Eligibility criteria:
inclusion criteria: * fifty patients undergoing opcab with preoperative hematocrit levels lower than 35% exclusion criteria: patient who has * open heart surgery history before * thrombosis history * myocardial infarction (mi) within 7days recently * liver or kidney disease * been scheduled emergency surgery
anti-migration system for anti-reflux oeso-gastric stent (antimig)

Conditions: Stent Migration; GastroEsophageal Cancer

Summary: the aim of this prospective, controlled, randomized, multicentre, single-blind study is to compare the rate of intragastric migration of 2 types of esophageal stents with and without an anti-migration device placed for locally advanced or metastatic malignant stenosis of the gastroesophageal junction.

in order to reduce the rate of spontaneous intragastric migration of esophageal stent placed for gastroesophageal junction tumor, anti-migration device has been developed. pilot studies suggest the absence of morbidity of this device, but no comparative study has been conducted to confirm the interest of this anti-migration device. the aim of this study is to compare the rate of intragastric migration of 2 types of esophageal stents with and without an anti-migration device placed for locally advanced or metastatic malignant stenosis of the gastroesophageal junction. * main objective: to evaluate the rate of intragastric migration of 2 types of esophageal stents (one with and the second without anti-migration device) placed for malignant stenosis of the gastroesophageal junction. * secondary objective(s): * degraded migration rate (m3 and m6) if patient alive, and duration of survival without dysphagia * comparison of the morbidity of these two stents * comparison of the effectiveness of these two stents on dysphagia and reflux * clinical and technical failure rate of these two stents this is a prospective, controlled, randomized, multicentre, single-blind study.

Eligibility criteria:
inclusion criteria: 1. patient of both sexes aged 18 or over. 2. patient admitted to one of the investigation centers for dysphagia due to tumoral stenosis of the gastroesophageal junction, locally advanced or metastatic. 3. patient asa 1, asa 2, asa 3 4. absence of participation in another clinical study 5. signed informed consent 6. patients benefiting from the social security system. exclusion criteria: 1. patient referred for stenosis by extrinsic compression by an extra digestive mass 2. patients with contraindications relating to the procedures essential for the introduction of a stent 3. mediastinal radiotherapy or esophageal surgery history 4. patient under 18 or over 90 5. patient asa 4, asa 5 6. pregnant woman 7. patient unable to give personal consent 8. absence of signed informed consent

Keywords: stent migration gastroesophageal cancer esophageal stenosis esophageal cancer endoscopy