Kornimate/medical-research-clean huggingface dataset:
resuscitation failure, oxidative stress, and necroptosis as mortality predictor in septic patient

Conditions: Sepsis

Summary: resuscitation failure, oxidative stress and necroptosis were able to predict mortality in septic patient

this prospective cohort study was conducted at resuscitation room and icu of mohammad hoesin hospital, a single tertiary teaching hospital in palembang, south sumatera. this study was started after ethical and location authorization were unleashed in february to august 2019. inclusion criteria were patients aged 18 years old or above who met sepsis-3 definition and diagnosed with sepsis. exclusion criteria were patients whose family did not give any consent to participate, not treated at the icu, had a late diagnosis (\>24 h), pregnant, and diagnosed with brain dead. drop out criteria including patients who died \<4 h after diagnosed and could not be followed in 28 days. investigators were trained to identified all eligible subjects. all the subjects had a standard resuscitation and their blood was taken to be examined at the laboratory. subjects were observed in 28 days whether there were any mortality or not. failed resuscitation defined by examined lactate level ≥ 2 mmol/l or lactate reduction \<20%. data was statistically analyzed with stata™

Eligibility criteria:
inclusion criteria: * participants aged 18 years old or above * diagnosed sepsis using sepsis-3 definition exclusion criteria: * participants whose family did not give any consent to participate * not treated at the icu * had a late diagnosis (\>24 h) * pregnant * brain dead
ct/mr-us automatic fusion system in pre-procedure planning for radiofrequency ablation

Conditions: Hepatocellular Carcinoma

Summary: to prospectively evaluate the technical success rate of real-time computed tomography/ct/magnetic resonance imagingmr and -ultrasound (ct/mri-us) automatic fusion system and the long-term therapeutic efficacy of radiofrequency ablation (rfa) guided by automatic fusion in hepatocellular carcinoma (hcc) patients.

rfa is one of commonly used local therapies for primary or secondary liver tumors. for successful and safe procedure, safe route of electrode and lesion visibility are essential for rfa, and the conditions are usually evaluated on pre-rfa planning ultrasonography (usg). however, rfa is sometimes aborted due to limited sonic window of various cause and challenging identification of small isoechoic tumors or hepatocellular carcinomas among dysplastic nodules . therefore, precise targeting and assuring safe route would be of clinical importance. in this preliminary study, investigators attempted to determine automatic us and ct/mr fusion technique would be able to improve rfa feasibility in patients with liver tumors.

Eligibility criteria:
inclusion criteria: * pathologic or typical imaging based diagnosis of hcc * multiphase ct or mri within 3 months ahead of procedure * no evidence of distant metastasis * no contraindications for conventional rfa procedure in our institute, which are uncontrolled coagulopathy (international standard ratio ≥ 1.6, or platelet \> 50,000), poor cooperation, unfeasible for sedation, portal vein tumor thrombus, tumor number \>4, largest tumor size \> 5cm, and tumors abutting portal vein or bile ducts bigger than segmental branches. exclusion criteria: * lack of multiphase ct or mri withing 3 months ahead of procedure * rfa planned for palliative purpose * diagnosed as non-hcc malignancy * right hepatectomy state

Keywords: radiofrequency ablation fusion imaging
pain index extracted from eeg in monitoring chronic pain

Conditions: Chronic Pain; Pain Assessment

Summary: pain is a subjective feeling,and pain experts have been trying to assess it using objective methods. pain index (pi) is extracted from electroencephalographic as an objective diagnostic tool for chronic pain. this study is a diagnostic test aims to explore the reliability and validity of pi, with numerical rating scale(nrs) as the gold standard.

chronic pain outpatients between 18 and 80 years old, nrs ≥4 at first visit and receive injection or shockwave therapy will be included. after informed consents signed, the age, gender, dominant hand and hospital anxiety and depression scale (hads) will be collected. each patient will be connected with a multifunctional monitor hxd-1 for 8 minutes to access eeg in a quiet environment before pain treatment and 30 minutes after pain treatment. nrs will also be recorded before pain treatment and 30 minutes after pain treatment. pi will be extracted from eeg by analysts. in order to reduce environmental effects, the same quiet research environment will be used throughout the study. all data will be obtained and recorded by the same person, and all pi will be analyzed and calculated by the same person. spss 20.0 will be used to analyze the data, pearson's correlations and kappa consistency test to analyze the validity and reliability of pi. the receiver operating characteristic curve will be use to analyze the sensitivity and specificity of pi to evaluating moderate and severe pain(nrs≥4). a multiple linear regression equation with pi as dependent variable and anxiety score and depression score as independent variables will be used to evaluate the influence of anxiety and depression on pi.

Eligibility criteria:
inclusion criteria: * 1.chronic pain patients diagnosed lumbar disc herniation, osteoarthritis or other chronic pain diseases, who will received injection therapy or shockwave therapy at clinic. * 2.patients age 18-80 years-old * 3.patients with an nrs pain score ≥ 4, * 4.patients who voluntarily participate in the test and sign the informed consent forms. exclusion criteria: * 1.patients with central nervous system disorders, such as epilepsy, cerebral infarction, or cerebral hemorrhage, * 2.patients with mental disorders, * 3.patients with a history of long-term use of psychotropic drugs. * 4.patients who can't understand nrs.

Keywords: pain assessment electroencephalographic numerical rating scale pain index
asthma and allergy screening aa2000 (cross sectional)

Conditions: Asthma

Summary: asthma screening of 493 asthma patients

questionnaire, and testing

Eligibility criteria:
inclusion criteria: respiratory symptoms suggestive for asthma - exclusion criteria:copd -

Keywords: asthma airway hyperresponsiveness asthma management
comparative effects of sensory re-education and neural mobilization in cts patients

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: the aim of study is to compare the effects of sensory re-education and neural mobilization in cts patients.

this study will be randomized clinical trial that will be conducted at services hospital lahore and government teaching hospital shahdara. in this study 48 participants with cts will be included as per sample size calculation through non-probability convenience sampling technique. participants that achieve the required standards of inclusion and exclusion criteria will be randomly allocated using online randomization tool into two groups. group a will receive sensory re-education therapy, strengthening exercises and kinesio taping for 60 minutes, group b will be given neural mobilization techniques, strengthening exercises and kinesio taping for 60 minutes with short rest intervals. both treatments will be given 3 days per week for 12 weeks.

Eligibility criteria:
inclusion criteria: * patients of both genders age 20-50 years with mild and moderate carpal tunnel syndrome. * patients having positive score on cts specific test (phalen's test and tinel's test). * patients with pain, paresthesia and hyperesthesia at the course of median nerve. * patients that are clinically diagnosed with carpal tunnel syndrome by physician. patients having bmi \>25 (kg/m2). exclusion criteria: * patients with polyneuropathies. * patients with carpal tunnel syndrome due to any systemic illness (diabetes mellitus, thyroid diseases and r.a). patients having cervical radiculopathy. patients with history of wrist fracture. patients getting steroid injections and after cts surgery. obese and pregnant female with carpal tunnel syndrome. patients with any cognitive or neurological problems are excluded from study.

Keywords: carpal tunnel syndrome, grip strength, sensory reeducation,
development of a methodology to design a high order sliding mode controller for drug dosage

Conditions: Diabetes; Hypertension; Anesthesia

Summary: the aim of this observational study is to create a data base to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.

the aim of this observational study is to create a database to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system. the observed drugs in this study are fast acting insulin, propofol and sodium nitroprusside. the effect of insulin will be measured by a continuous glucose monitor, the effect of propofol by a bispectral index monitor and the the effect of sodium nitroprusside by a invasive blood pressure monitor.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status i, ii, ii exclusion criteria: * impossibility to measure depth of anesthesia or invasive blood pressure. impossibility of using glucose monitor.
study to test the accuracy of a prototype handheld pt/inr device

Conditions: Blood Coagulation Disorders

Summary: the purpose of this study is to measure prothrombin time (pt) on an experimental device and a commercially available device on persons receiving coumadin (warfarin)treatment.

this study will require participants to have up to 2 finger-punctures taken and sample tested on a strip and meter system for both the experimental and commercially available devices.

Eligibility criteria:
inclusion criteria: * currently taking coumadin (warfarin) * aged 18 years or older * able and willing to provide informed consent * can understand (read and write) english exclusion criteria: * none
magnetic resonance imaging evaluation of inner ear pathology using intra-tympanic contrast agent

Conditions: Meniere's Disease

Summary: this is a pilot study of patients with clinical symptoms of ménière's disease using injection of diluted magnetic resonance imaging (mri) contrast agent into the ear to evaluate inner ear structures. the goal is to reproduce imaging findings described by non-united states (us) institutions, improve on image quality with decreased scan time and evaluate the dynamics of the contrast movement into the inner ear structures.

participants will be scheduled for study sessions on 2 consecutive days to include consent, baseline audiometric evaluation, intra-tympanic contrast administration, serial mr imaging, and follow-up audiometry evaluation in the injected ear. participants over 59 years old or who have medical conditions will have a blood test to check kidney function to ensure they can safely receive the contrast.

Eligibility criteria:
inclusion criteria: * symptoms and clinical exam consistent with ménière's disease * ability to undergo mr exam * interest in participating in this study * ability to provide informed consent exclusion criteria: * children (under age 18), * contraindication to mr imaging (see attached ucsd mr screening form) * claustrophobia precluding mr exam without sedation * contraindication to receiving intravenous gadolinium-based contrast agent (see attached ucsd contrast policy) * patients who are pregnant or breast feeding (intravenous contrast agents are category c) * contraindication to osmotic challenge (congestive heart failure, renal failure, hepatic failure)

Keywords: meniere's disease endolymphatic hydrops
sipuleucel-t in metastatic castrate resistant prostate cancer

Conditions: Prostate Cancer

Summary: multicenter open label, uncontrolled study that enrolled men with metastatic castrate resistant prostate cancer previously treated with sipuleucel-t in the androgen dependent setting in the dendreon p-11 study. the study was divided into active and long term follow-up (ltfu) phases.

multicenter open label, uncontrolled study that enrolled men with metastatic castrate resistant prostate cancer previously treated with sipuleucel-t in the androgen dependent setting in the dendreon p-11 study. the study was divided into active and long term follow-up (ltfu) phases. during the active phase eligible subjects received one infusion of sipuleucel-t every two weeks for for a total of three infusions. subjects returned to the clinic for week 6, week 10, month 6, and month 12 visits. after the month 12 visit, subjects were to enter the long term follow-up phase, in which they were contacted every 6 months via telephone. study objectives: primary: evaluate the immune response generated by sipuleucel-t. secondary: evaluate the safety of sipuleucel-t and explore the correlation between sipuleucel-t immune response and overall survival.

Eligibility criteria:
inclusion criteria: * previously randomized in dendreon's p-11 study (nct00779402) and received at least one infusion of sipuleucel-t * radiologic evidence of metastasis * castrate resistant prostate cancer. subjects must have current or historical evidence of disease progression concomitant with surgical or medical castration, as demonstrated by psa progression or progression of measurable disease or progression of non-measurable disease * castrate level of testosterone (\< 50 ng/dl) achieved via medical or surgical castration * adequate hematologic function exclusion criteria: * eastern cooperative oncology group (ecog) performance status \> 2 * treatment with chemotherapy within 3 months prior to registration * treatment with systemic corticosteroids, abiraterone acetate, external beam radiation therapy, or any investigational product for prostate cancer within 28 days prior to registration * treatment with commercial sipuleucel-t (provenge®) * current or imminent pathologic long-bone fracture or spinal cord compression * known malignancies other than prostate cancer likely to require treatment within 6 months following registration * a requirement for systemic immunosuppressive therapy for any reason * a history of allergic reactions attributed to compounds of similar chemical or biologic composition to sipuleucel-t or gm-csf * any infection requiring antibiotic therapy or causing fever within 1 week prior to registration * any surgery requiring general anesthetic within 28 days prior to registration

Keywords: metastatic castrate resistant prostate cancer prostate cancer prostate immune therapy immunotherapy vaccine dendritic cells antigen-presenting cells antigen presenting cells cancer vaccine prostatic adenocarcinoma sipuleucel-t castration resistant prostate cancer (crpc) booster retreatment immune memory immune response
granulocyte colony stimulating factor versus platelet rich plasma and outcomes of frozen embryo transfer

Conditions: Infertility

Summary: the rationale behind this current study is to assess the impact of using prp versus gcsf on the outcomes of frozen embryo transfer in term of clinical pregnancy rates.

introduction and study rationale despite the advancements in the treatment of infertility, repeated failure of implantation continues as a challenging difficulty. embryo implantation is affected by many factors. many efforts were made to improve the implantation rate by different methods blastocyst transfer, assisted hatching, preimplantation genetic screening, hysteroscopy, removal of hydrosalpinges and endometrial scratch. furthermore, infertility specialists suggested some empirical methods like the infusion in the uterine cavity of platelet-rich plasma (prp) in patients with thin endometrium which has been shown to be effective in improving the pregnancy rate. another factor is granulocyte colony stimulating factor (g-csf) which has receptors in endometrial cells and may have a role in implantation. the use of g-csf in assisted reproductive technology (art) has been tried by many research studies either via intrauterine or systemic administration. there is only one study compared the impact of prp and gcsf administration on the pregnancy rate and on the endometrial thickness with a small sample size. the rationale behind this current study is to assess the impact of using prp versus gcsf on the outcomes of frozen embryo transfer in term of clinical pregnancy rates. study objectives primary: the primary objective of the study is to compare the clinical pregnancy rate determined by presence of fetal heart beat in transvaginal ultrasound after embryo transfer in all groups. secondary: to compare the following in the three study arms: * chemical pregnancy determined by positive serum β-hcg, 2 weeks after embryo transfer. * clinical pregnancy rate adjusted by the endometrial thickness (thin versus normal) in all groups. * clinical pregnancy rate adjusted by pgs in all groups * the midluteal endometrial thickness in all groups (histopathology \& tvus). * the number of women who had thin endometrium and reaches endometrial thickness ≥ 7 mm after using g-csf or prp. * implantation rate * miscarriage rate * live-birth rate

Eligibility criteria:
inclusion criteria: * all women aged 20-40 years * non-smoker * bmi \< 30 * normal endometrial cavity confirmed by hysteroscopy * visiting the center for ivf by frozen embryo transfer during the period of the study exclusion criteria: * history of anti-phospholipid syndrome confirmed by serological tests. * history of any hematological and immunological disorders * history of chromosomal or genetic abnormalities in the patient or in the family * any uterine abnormalities (congenital or acquired) * previous uterine surgeries except caesarean section * hypersensitivity to g-csf * uncontrolled systemic disease

Keywords: gcsf prp pregnancy
pediatric sars-cov-2 infections: course of covid-19, immune responses, complications and long-term consequences

Conditions: Hypohidrotic Ectodermal Dysplasia

Summary: longitudinal study of 56 households with at least one member who had covid-19 to compare the course of illness, immune responses, and long-term consequences of sars-cov-2 infection in hed patients with those of control subjects of the same age group. complete households are investigated, including women who are pregnant when exposed to the virus and their newborn child(ren).


Eligibility criteria:
inclusion criteria: * household with one or more members registered as patient(s) in the university hospital erlangen * at least one person \<18 years of age * at least one household member who has or had a sars-cov-2 infection confirmed by a positive pcr test, detection of specific antibodies against this virus, or by development of covid-19 symptoms after being in close contact with a person known to be infected with sars-cov-2 * informed consent exclusion criteria: * missing informed consent of one or more household members * language barriers to communication that would prevent informed consent
single dose study of bms-820836

Conditions: Depression

Summary: the purpose of this study is to determine the safety and tolerability of bms-820836 after single doses


Eligibility criteria:
inclusion criteria: * body mass index (bmi) of 18 to 30 kg/m2, inclusive and weight ≥ 50 kg * right-handed, non-ambidextrous subjects for part 2 * men and women, ages 18 to 55 years, inclusive exclusion criteria: * women of child bearing potential (wocbp) who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for up to 8 weeks after the last dose of investigational product * wocbp using a prohibited contraceptive method * women who are pregnant or breastfeeding * sexually active fertile men not using effective birth control if their partners are wocbp * any significant acute or chronic medical illness * current or recent (within 3 months) gastrointestinal disease * history of cholecystectomy * any major surgery within 4 weeks of study drug administration * any gastrointestinal surgery that could impact the absorption of study drug * donation of blood or plasma to a blood bank or in a clinical study (except a screening visit) within 4 weeks of study drug administration * blood transfusion within 4 weeks of study drug administration * inability to tolerate/swallow oral medication * difficulty with venipuncture and/or poor venous access * self-reported smokers * recent (within 1 year) of psychostimulant use (cocaine, methylphenidate, amphetamines, ecstasy) * confirmed resting supine systolic blood pressure \> 130 mmhg * confirmed resting supine diastolic blood pressure \> 80 mmhg * confirmed qt value ≥ 500 msec * confirmed qtc (bazett) value ≥ 450 msec * history of any significant drug allergy (such as anaphylaxis or hepatotoxicity) * history of peppermint allergies * history of brain conditions (e.g. history of stroke, head trauma, etc.) * history of or current psychiatric conditions * history of claustrophobia
a multicenter cross-sectional study of shear wave ultrasound imaging in evaluating supraspinatus tendon elasticity

Conditions: Diabetes Mellitus, Type 2

Summary: the goal of this multi-center, cross-sectional, observational study is to test and compare the difference of the supraspinatus tendon's elasticity between diabetics and healthy people. the main questions it aims to answer are: * ultrasonic characteristics of supraspinatus tendon in diabetic patients * influencing factors of elastic value and thickness of supraspinatus tendon participants will be asked to: * perform ultrasound examination of the shoulder join. * fill in a survey with certain questions on their basic information.


Eligibility criteria:
inclusion criteria: ① age range (above 18 years old); ② non-professional athletes; ③ no medical history of shoulder and neck pain; ④ ultrasound examination (-). exclusion criteria: ① pregnant women or postpartum 1 year; ② shoulder pain with active or passive cervical motion; ③ history of upper extremity trauma; (4) shoulder surgery or treatment history, intra-articular injection history, use history of glucocorticoids, estrogens, quinolones and cholesterol drugs; (5) shoulder joint fear test (shoulder joint abduction 90°, slowly increasing external rotation, the subject had a positive expression of fear); (6) evidence of adhesive shoulder joint bursitis, such as the passive range of motion of the 2 motion planes of the shoulder joint is obviously limited; ⑦ systemic autoimmune diseases, metabolic diseases, endocrine diseases, psoriasis; ⑧ unable to complete the relevant movements and positions; ⑨ those who are reluctant to continue the experiment and ask to quit.

Keywords: supraspinatus tendon shear wave elastic imaging ultrasound