Kornimate/medical-research-clean huggingface dataset:
compassionate use of stanate (tm) [stannsoporfin]

Conditions: Neonatal Jaundice; Hyperbilirubinemia

Summary: the purpose of this protocol is to make stanate (tm) \[stannsoporfin, tin-mesoporphyrin\] available to infants who meet the following criteria: 1. the infant has a very high level of bilirubin without an adequate clinical response to phototherapy; 2. the infant requires an exchange transfusion; and 3. the family refuses to allow the administration of blood products, particularly on religious grounds, such as within the jehovah's witness community.


Eligibility criteria:
* term or near term neonate * elevated serum bilirubin * failing phototherapy * requires exchange transfusion * family refuses exchange transfusion on religious grounds

Keywords: hyperbilirubinemia jaundice tin-mesoporphyrin stannsoporfin exchange transfusion neonatal hyperbilirubinemia
repetitive transcranial magnetic stimulation for the treatment of the tardive dyskinesia.

Conditions: Tardive Dyskinesia

Summary: the purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rtms) in the treatment of the tardive dyskinesia.

the study was a parallel control design trial for 2 weeks. patients with schizophrenia were treated with 10-hz rtms on left motor cortex (added to the ongoing treatment). clinical symptoms and mep were assessment before and after rtms treatment.

Eligibility criteria:
inclusion criteria: * the diagnosis of schizophrenia according to dsm-iv； * at least two item of abnormal involuntary movement scale（aims） must be 2 points or higher * these symptoms are not from parkinson，tourette's syndrome,huntington disease * signed an informed consent exclusion criteria: * rtms contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure * patients to be diagnosed according to dsm-iv for substance abused, development delayed * current treatment with anticonvulsant acting drugs such as anticonvulsants, benzodiazepines * acute risk of suicide and impulse * history of epileptic seizures or the presence of epileptic activity documented on the basis of eeg * pregnant and lactant women

Keywords: tardive dyskinesia. rtms
early assessment of response to treatment of metastatic lung tumors based on circulating tumor dna

Conditions: Metastatic Non-small Cell Lung Cancer

Summary: in patients with locally advanced or metastatic tumors, first-line therapeutic management is based on the use of targeted therapies (egfr, braf alk and ros1 inhibitors), immunotherapies (anti-pd1/ anti-pdl1-antibodies or chemotherapy. despite patient selection based on histo-pathological and molecular criteria, not all patients respond to treatment. there are currently no markers to definitively guarantee a patient's response. an alternative is to identify early patient response to treatment. the investigator hypothesize that change in circulating tumor dna concentration (ctdna) allow to early identify patients' therapeutic response (and non-response) of patients, regardless of the type of treatment used in the first line setting.

the primary objective is to determine whether early evolution (between baseline and week 3) of circulating tumor dna concentration predicts the radiological response to first-line treatment of advanced or metastatic nsclc patients, regardless of treatment

Eligibility criteria:
inclusion criteria: * metastatic or locally advanced non-small cell lung cancer (stage iii or iv) * at least one measurable target according to recist criteria * identification of at least one molecular alteration in the tissue sample analyzed in the framework of patient management * performance status 0 to 2 * affiliated to a social security system * patient who can be followed under the protocol * patient agreed to participate in the study and gave his/her express consent exclusion criteria: * minor * small cell or mixed bronchial cancer * radiotherapy (except radiotherapy for antalgic purposes) during the last 7 days * patient who has already started a first line of treatment * patient already included in an interventional research protocol that may have an impact on the results of the elucid study * history of cancer (with the exception of non-melanoma skin, cervical cancer in situ, adequately treated) with sign of illness during the last 5 years * patient which, does present a substantial risk of recurrence. * major under guardianship, curators or deprived of liberty * pregnant or lactating woman, or of childbearing age without effective contraception * not affiliated to a social security system * inability to understand the protocol and / or to give express consent
cartilage recovery in adults with knee osteorthritis by mesenchymal cell therapy: randomized trial of radiologic and clinical outcomes

Conditions: Knee Osteoarthritis

Summary: the treatment of osteoarthritis (oa) of the knee remains still controversial. despite that fact advanced stages with symptomatic and functional improvement are obtained with total knee replacement, however, there is no treatment that neither modifies the natural history of this disease, nor avoid joint replacement surgery in young patients in whom the prosthesis has conflictive indications. moreover, prosthetic surgery leads to lower long-term survival and in older patients, higher morbidity and mortality. cell therapy promises to be a treatment option through the use of mesenchymal cells with the capacity control inflammatory responses and trigger the differentiation into chondrocytes. here we propose a randomized placebo-controlled clinical trial to evaluate radiologic and clinical outcomes in patients with knee oa.


Eligibility criteria:
inclusion criteria: pain most days for the last month. presence of osteophytes. synovial fluid with mechanical characteristics. morning stiffness for less than 30 minutes in the affected joint. patellar crepitus. patients aged 40 years or older and less than 60 years. radiological criteria for osteoarthritis of the knee kellgren-lawrence 2 to 4 in comparative radiographs with knee support taken in the last 12 months prior to consultation. pain in one or both knees according to a visual analogue scale of 5 or more, out of 10 points in the last 3 months. exclusion criteria: consumption of non-steroidal anti-inflammatory drugs or anticoagulants in the last 14 days. patient with a history of joint infiltration or arthroscopic surgery of the affected knee in the last 6 months. participants in another treatment or research study within the past year. pregnant or lactating patients. patient with active tumor pathology or a history of oncological disease. patient with metabolic disease and/or uncontrolled coagulopathy at the assessment time. patients who have received previous treatments such as microfractures, and osteochondral allografts. patients with present meniscal lesions. patients with a history of thyroiditis or thyroid nodules with increased antithyroglobulin antibodies. patients with a history of osteoarticular infection in the last 5 years or active at the time of assessment.
pilot study evaluating somatostatin receptor's pet imaging to detect inflammatory phases of myocarditis

Conditions: Myocarditis

Summary: infectious myocarditis are frequent, most of the time viral and can evolve to cardiac insufficiency. the diagnosis is difficult because they can mime an acute coronary syndrome. approximately 10 % of patients with acute infarction suspected, have a normal angiography, and half of them has in fact a myocarditis, as showed studies of cardiac mri among which some realized in our department . however, anomalies observed in mri are not specific and it is necessary to use multiple criterions. a new radiopharmaceutical, the 68ga-dotatoc, specific of somatostatin's receptors which are over expressed by the inflammatory cells, has recently showed the capacity to identify myocarditis, but only in a small group of 6 patients. the investigators make assumptions: 1. this radiopharmaceutical is enough sensitive to detect most of the acute inflammatory myocarditis which are identified by the mri and 2. it could maybe allow to identify myocarditis with a persistent subacute or chronic inflammation, which are difficult to identify with cardiac mri, and it would be a new information able to guide the medical decision. primary objectif: to determine if pet with 68ga-dotatoc is enough sensitive to identify myocarditis in acute inflammatory phase by hospitalized patients with suspected acute infarction and with normal angiography and who have a high probability of myocarditis identified by mri. disease prevalence will be close to 100 % at baseline secondary objectives: 1. estimate the frequency of inflammatory forms (subacute or chronicle), with a 68ga-dotatoc pet at 3 to 5 months from baseline, when classic signs of acute inflammatory generally disappeared (crp, troponin-i, myocardial oedema in mri). 2. analyze the concordance of the results of 68ga-dotatoc tep by two readers


Eligibility criteria:
inclusion criteria: * adult subjects who have given their written consent to participate in the study. * patients without history of heart disease, hospitalized for acute infarction suspected with positive troponine, normal or subnormal angiography and which have a high probability of acute inflammatory myocardities on the secondarily realized mri (= 2 criteria of lake louise) * no contraindication to perform a 68ga-dotatoc-pet . * patient belong to a social security scheme. exclusion criteria: * patients under guardianship or curatorship. * pregnancy, breastfeeding and woman of childbearing age without effective contraception * impossibility to perform a pet with 68ga-dotatoc (patient agitated). * impossibility to schedule pet/ct before the deadline = in 7 days since the beginning of the hospitalization.

Keywords: 68-ga-dotatoc pet myocarditis
a study to characterize the prevalence of overweight and obesity among patients with established cardiovascular disease

Conditions: Obesity; Overweight

Summary: the purpose of this observational study is to measure how many people are overweight or obese amongst patients with a diagnosed cardiovascular disease (cvd). the study also aims to characterise the population including the presence of cardiovascular (cv) risk factors in a number of countries across the globe representing different geographies, ethnicities, as well as different healthcare systems.


Eligibility criteria:
inclusion criteria: 1. informed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol). 2. adults, age above or equal to 18 years at the time of signing informed consent. 3. have established cvd and equal to or greater than 1 follow up appointment following an acute event from at least one of the following: * prior myocardial infarction * prior stroke (ischemic or haemorrhagic stroke) * symptomatic peripheral arterial disease (pad), as evidenced by intermittent claudication with ankle-brachial index (abi) below 85 (at rest), or peripheral arterial revascularization procedure, or amputation due to atherosclerotic disease exclusion criteria: 1. previous participation in this study. participation is defined as having given informed consent in this study 2. mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation 3. patients with known congenital heart disease/malformation
conventional or minimally invasive surgical technique for the treatment of furcation defects using enamel matrix derivative and anorganic bovine bone - a randomized controlled clinical trial.

Conditions: Furcation Defects; Periodontal Disease

Summary: this clinical study compared a conventional surgical technique (cst) and a minimally invasive surgical technique (mist) in the regenerative treatment of mandibular furcation defects.

using a split-mouth design, fifteen patients with bilateral class ii and iii furcation defects were treated with mist (test group) or cst (control group). furcation defects in both groups were filled with anorganic bovine bone (abb) and enamel matrix derivative (emd). patient-centered outcomes including analyses of pain, discomfort, edema, hematoma, root hypersensitivity and daily activities interference were recorded using a visual analogue scale seven days after surgeries. clinical and radiographic parameters were assessed at baseline and 6 months postoperatively. data were statistically analysed.

Eligibility criteria:
inclusion criteria: (i) subjects with a diagnosis of periodontitis; (ii) presence of one pair of contralateral mandibular molars with buccal / lingual furcation defects; (iii) non-smokers; (iv) plaque index \< 20%. exclusion criteria: (i) patients that presented systemic disease; (ii) had taken antibiotics in the past 6 months prior to surgery; (iii) pregnant women or lactating mothers; (iv) molars with periapical disease; (v) cervical restorations or prosthesis closer than 1 mm to fornix; (vi) lingual furcation defects presenting gingival recession (gr)

Keywords: microsurgery, furcation defects, periodontal disease, enamel matrix proteins, bone substitutes
gegen qinlian tang and probiotics for radiation enteritis

Conditions: Acute Radiation Enteritis

Summary: the purpose of this clinical study is to evaluate whether bifidobacterium triple viable capsules, alone or in combination with gegen qinlian decoction, can effectively prevent and treat acute radiation enteritis in patients undergoing abdominal or pelvic radiotherapy. the study aims to answer the following question: can probiotics, with or without the addition of herbal medicine, reduce the incidence and severity of radiation-induced intestinal injury and improve the quality of life for patients during and after radiotherapy? a total of 60 patients with malignant tumors receiving abdominal or pelvic radiotherapy will be recruited and randomly assigned to one of three groups: a control group (no intervention), a probiotics-only group (bifidobacterium triple viable capsules, three capsules twice daily), and a combination therapy group (probiotics with modified gegen qinlian decoction tailored to individual symptoms). the primary outcome will be the incidence and severity of acute radiation enteritis, assessed using the rtog/eortc grading criteria (0-iv levels). daily observations will be recorded during radiotherapy, with follow-up lasting three months after the completion of treatment. this study seeks to provide evidence for the use of probiotics and herbal medicine as effective strategies to mitigate the side effects of radiotherapy and improve patient outcomes.


Eligibility criteria:
inclusion criteria:1.age:participants aged 18 to 80 years.2.diagnosis: patients diagnosed with malignant tumors confirmed by cytological or pathological examination.patients scheduled for abdominal or pelvic radiotherapy based on treatment guidelines.3cognitive and communication ability:participants must have clear consciousness and normal cognitive abilities to communicate effectively.4.consent:participants must provide written informed consent and agree to participate in the study. family members must also provide consent if applicable.5.willingness to cooperate:participants must be willing to comply with the study procedures and requirements. exclusion criteria:1.history of severe intestinal diseases:patients with a history of severe intestinal diseases, including ischemic bowel disease, ulcerative colitis, crohn's disease, or other chronic inflammatory bowel conditions.2.recent antibiotic use:patients who have received antibiotic treatment within the past 2 years.3.severe organ dysfunction:patients with severe liver or kidney dysfunction, as determined by clinical assessment or laboratory tests.4.comorbidities and other major diseases: patients with other serious illnesses that may interfere with the study protocol or compliance, including but not limited to cardiovascular, respiratory, or neurological diseases.5.inability to participate:patients unable to cooperate with the study procedures due to physical or psychological reasons.patients who are likely to withdraw midway through the study.6.incomplete medical records or refusal to share data:patients who refuse to share their medical records or have incomplete medical documentation.
can blood flow restriction therapy improve strength for shoulder external rotators better than exercise alone

Conditions: Muscular Weakness

Summary: the purpose of this study is to evaluate the ability of blood flow restriction therapy to improve strength of shoulder muscles during the sidelying external rotation (er) exercise versus a control group who only performs the sidelying er exercise.

the purpose of this study is to determine if blood flow restriction (bfr) therapy is superior at increasing strength of the shoulder (supraspinatus, infraspinatus, posterior deltoid, and middle deltoid) and increasing tendon size of the supraspinatus and infraspinatus (as determined by diagnostic ultrasound) while performing the sidelying external rotation exercise compared to those who only perform the sideyling external rotation exercise without bfr. subjects will be randomized to one of two treatment groups: exercise with bfr or exercise alone. recruitment will be a sample of convenience consisting of healthy adults (age range 22 to 45). subjects will perform the sidelying external rotation exercise 2 times a week for an 8 week period.

Eligibility criteria:
inclusion criteria: 1. healthy adult (age 18 and older) with no current shoulder pathology exclusion criteria: 1. current neck, shoulder (or general upper extremity), and/or thoracic spine pathology 2. shoulder surgery (or general upper extremity surgery) during the prior 6-month time period 3. cervical/thoracic spine surgery during the prior 1 year 4. subject having one or more contraindications for bfr training.

Keywords: infraspinatus, external rotators, blood flow restriction
evaluation of exercise capacity and activity role adequacy in patients with adult bronchial asthma

Conditions: Asthma; Activity Role Qualification; Fear of Movement

Summary: the aim of this study was to evaluate exercise capacity and activity role adequacy in patients with adult bronchial asthma.

asthma is a chronic inflammatory disease characterized by increased airway sensitivity to various stimuli and reversible airway obstruction. asthma is a disease with high morbidity and mortality despite all advances in pathogenesis, diagnosis and treatment in the world. it is estimated that there are approximately 300 million asthmatic patients in the world. in our country, approximately one out of every 12-13 adults and one in 7-8 children have asthma. clinical symptoms of asthma include shortness of breath, wheezing, coughing. increased symptoms in asthmatic patients lead to impaired respiratory function. in chronic respiratory problems, participants restrict their activity to avoid shortness of breath. as a result, physical fitness levels are reduced, shortness of breath occurs at earlier workloads, and participants do less activity. in chronic disorders, managing the disease alone may not be enough to optimize normal functioning in daily life. in literature, it is seen that daily life activities, quality of life, school performance and work performance are affected in asthmatic patients. it is thought to be useful in determining the course of treatment to be given to the patient in the course of the disease.

Eligibility criteria:
inclusion criteria: * be diagnosed with bronchial asthma by a chest physician * being between the ages of 18-65 * being in a stable period * work in the last 12 months exclusion criteria: * severe chronic disease other than bronchial asthma (cancer, chronic obstructive pulmonary disease, chronic heart failure, neurological disease, etc.). * any physical disability that prevents walking * unable to comply with tests * lack of reading, speaking and writing in turkish
nurse-led case management for diabetes and cardiovascular disease patients with depression

Conditions: Depression

Summary: this study will evaluate the effectiveness of a nurse-led case management intervention in improving disease control and depression symptoms in adults with diabetes and/or heart disease who are also depressed.

depression is a serious medical illness that has been associated with increased risk for heart disease and diabetes. depression may negatively impact aspects of self-care that are required to effectively manage such long-term diseases. in depressed people who have heart disease and/or diabetes, treatment for depression appears to result in only limited improvements in depression symptoms and no improvements in heart disease and diabetes symptoms. an integrated treatment approach may be more effective in improving all three conditions. this study will evaluate the effectiveness of a nurse-led case management intervention in improving disease control and depression symptoms in adults with diabetes and/or heart disease who are also depressed. participants in this single-blind study will be randomly assigned to take part in the case management intervention or receive usual care. all participants will attend 5 in-person study evaluation visits and receive 4 follow-up phone calls over 24 months. at each of the study visits, measurements of height, weight, waist size, and blood pressure will be taken. at study evaluations, blood and urine samples will also be taken. participants will be asked not to eat for 8 hours before providing blood samples at 3 of the visits. during follow-up phone calls participants will answer various questions. the case management intervention will entail approximately 10 visits with a trained nurse at the clinic or by telephone. participants in this group will receive educational materials about how to manage diabetes and/or heart disease and stress or depression. nurses will also provide guidance and support in managing medications, phone calls to check participants' progress, and assistance in setting personal goals and in managing physical health problems and symptoms of depression or stress. outcomes will be measured at months 6, 12, 18, and 24 months.

Eligibility criteria:
inclusion criteria: * diagnosis of diabetes and/or heart disease * poor disease control (defined as an hba1c level of at least 8.5%, blood pressure greater than 140/90 mm hg, ldl cholesterol greater than 130 mg/dl) * diagnosis of major depressive disorder exclusion criteria: * history of psychosis * at high risk for suicide * cognitive impairment * current alcohol or substance abuse disorder * does not own a telephone * currently seeking psychiatric care * pregnant or breastfeeding * currently enrolled in a group health cooperative disease management program * terminal illness * plans to leave group health cooperative in less than a year * does not speak english

Keywords: major depressive disorder diabetes heart disease
aspiration of subglottic secretions using hi-lo evac endotracheal tube: tube size and incidence of suction lumen dysfunction

Conditions: Aspiration of Subglottic Secretions

Summary: to evaluate the correlation between endotracheal tube size and incidence of dysfunction of suction lumen of hi-lo evac endotracheal tube in critically ill patients who required mechanical ventilation for more than 48 hours.

in mechanically ventilated patients, aspiration of subglottic secretions is a widely used intervention for prevention of ventilator-associated pneumonia. using hi-lo® evac endotracheal tube (hi-lo evac; mallinckrodt; athlone, ireland), dysfunction of suction lumen and subsequent failure to aspirate the subglottic secretions is not uncommon. the objective of this prospective observational study is to determine the causes and the incidence of suction lumen dysfunction of evac endotracheal tube.

Eligibility criteria:
inclusion criteria: * critically ill patients with orotracheal intubation and anticipated duration of intubation more than 48 hours

Keywords: ventilator associated pneumonia prevention endotracheal intubation mechanical ventilation