Kornimate/medical-research-clean huggingface dataset:
probiotics for blepharitis in adults and children

Conditions: Blepharitis

Summary: the alteration of the intestinal microbiota through the use of specific probiotics can improve the clinical course of blepharitis by restoring intestinal and immune homeostasis. the purpose of this study is to define the possible positive impact of probiotics on patients with blepharitis.

from recent studies, it has emerged that the gut microbiota is a possible responsible for the stimulation of the innate immune response and its role in the pathogenesis of autoimmune diseases has been deepened. several clinical studies, in fact, support the existence of a connection between changes in the commensal intestinal microbiota ("dysbiosis") and autoimmune diseases. it has been seen that also ocular conditions like chalaziosis and uveitis are tied to dysbiosis. in addition, in a recent study probiotics were found to be safe and effective in the treatment of chalaziosis in children. other eye conditions that may be affected by changes in the gut microbiome are dry eye syndrome and blepharitis. under these conditions, a reduction in globet cells has often been noted. these cells produce the mucins present on the ocular surface, and therefore, their reduction involves the production of a thin and ineffective tear film. therefore, the study will cover patients with blepharitis (both adults and children), treated with specific probiotics to be taken daily. patients will then undergo a full ophthalmological examination each week for the first month, and then monthly until complete recovery for at least 6 months. in addition, at the time of enlistment and complete recovery, after venous sampling, the following biomarkers will be analyzed with cytometer and elisa: tnfα and lymphocyte subpopulations. with this study, therefore, the aim is to define the possible positive impact of probiotics on patients with blepharitis.

Eligibility criteria:
inclusion criteria: * blepharitis exclusion criteria: * eyelid infection * suspicion of malignancy

Keywords: microbiome/microbiota probiotics
human placental-derived stem cell transplantation

Conditions: Mucopolysaccharidosis I; Mucopolysaccharidosis VI; Adrenoleukodystrophy; Niemann-Pick Disease; Metachromatic Leukodystrophy; Wolman Disease; Krabbe's Disease; Gaucher's Disease; Fucosidosis; Batten Disease; Severe Aplastic Anemia; Diamond-Blackfan Anemia; Amegakaryocytic Thrombocytopenia; Myelodysplastic Syndrome; Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia

Summary: the purpose of this clinical trial is to investigate the safety of human placental-derived stem cells (hpdsc) given in conjunction with umbilical cord blood (ucb) stem cells in patients with various malignant or nonmalignant disorders who require a stem cell transplant. patients will get either full dose (high-intensity) or lower dose (low intensity) chemo- and immunotherapy followed by a stem cell transplantation with ucb and hpdsc.


Eligibility criteria:
inclusion criteria: * \< 55 years of age * life expectancy greater than 3 months * lansky performance status ≥ 50% (children) or karnofsky performance status ≥ 70% (adults) or ecog performance status 0-2 (adults) * dlco \> 50 percent predicted * left ventricular ejection fraction \> 40% estimated * creatinine clearance or estimated gfr . 60 ml/min/1.73m2 * serum bilirubin \< 1.5x upper limit of normal * transaminases \< 3x upper limit of normal * absence of uncontrolled infection * hiv negative exclusion criteria: * fanconi anemia * myocardial infarction within 6 months prior to enrollment or has new york heart association (nyha) class iii or iv heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities * uncontrolled infection * pregnant or breast-feeding females * received other investigational agents within 30 days prior to the start of the conditioning regimen

Keywords: umbilical cord blood stem cell transplantation placental stem cell inborn errors of metabolism marrow failure severe combined immunodeficiency disease aml all mds
the effect of an augmented reality game on pain, fear, and care satisfaction levels during allergy testing in children aged 4-12 years

Conditions: Augmented Reality

Summary: the aim of this study is to examine the effects of augmented reality (ar) games on pain, fear, and care satisfaction, and to contribute to the literature on innovative interventions that enhance the healthcare experiences of children undergoing allergy testing. h1: the pain level of children undergoing allergy testing in the ar group is lower than that of children in the control group. h2: the fear level of children undergoing allergy testing in the ar group is lower than that of children in the control group. h3: the care satisfaction level of children undergoing allergy testing in the ar group is higher than that of children in the control group.


Eligibility criteria:
inclusion criteria: * aged between 4 and 12 years. * scheduled to undergo an allergy test. * no visual impairments that would interfere with the use of augmented reality -applications. * no use of anxiolytic or analgesic medications within the last six hours. * willing to participate in the study, with parental/legal guardian consent as applicable. exclusion criteria: * younger than 4 years or older than 12 years. * not scheduled for an allergy test. * presence of visual impairments. * use of anxiolytic or analgesic medications within the last six hours. * unwilling to participate in the study or lacking informed consent.

Keywords: allergy pediatric augmented reality pain anxiety care satisfaction
postural tachycardia syndrome and vasovagal syncope in relation to serum electrolytes and adrenal insufficiency

Conditions: POTS - Postural Orthostatic Tachycardia Syndrome

Summary: the present study aims to: 1. estimate the prevalence of postural tachycardia syndrome and vasovagal syncope among adults patients attend the internal medicine clinic and icu in period from 11/2022 to 10/2023 2. detect of causes and the relationship between pots and vasovagal syncope and serum electrolytes, and serum cortisol.

postural orthostatic tachycardia syndrome (pots) is a common, although not so well-known variant of cardiovascular autonomic disorder characterized by an excessive heart rate increase on standing, symptoms of orthostatic intolerance and maybe syncope. the most common complaints are dizziness, weakness, rapid heartbeat and palpitation on standing. moreover, patients often report physical deconditioning and reduced exercise capacity as well as headache, brain fog, dyspnea, gastrointestinal disorders and musculoskeletal pain. the etiology of pots is largely unknown and three main hypotheses include an autoimmune disorder, abnormally increased sympathetic activity and catecholamine excess and sympathetic denervation leading to central hypervolemia and reflex tachycardia. the diagnostic criteria of pots in this study is increasing hear rate from supine position to active standing by \> 30 beat per minute and positive poor mans man tilt table test. on the other hand, vasovagal reflex syncope is the most frequent cause of transient loss of consciousness . the vasovagal reaction consists of vasodilatation and a heart rate decrease. during prolonged standing, this reaction is triggered by a reduction of the central blood volume because of pooling in the lower body veins, sometimes combined with other provocative factors . patients with reflex syncope may suffer from recurrent loss of consciousness. most of those patients also experience frequent presyncope, which can be just as incapacitating as syncope itself. vasovagal syncope is usually not a dangerous condition, because episodes are self-limiting. however, the quality of life of patients with recurrences can be seriously affected . the rapid loss of consciousness and the possibility of trauma tax the patients sense of physical control and self-esteem.

Eligibility criteria:
inclusion criteria: 1. patient above 18 years. 2. patient fulfilling diagnostic criteria of pots increase heart rate from supine position to active standing by \> 30 beat per minute within 10 minutes and positive poor mans man tilt table test. 3. patient with history of vasovagal syncope exclusion criteria: 1. age below 18 yrs old 2. patient with specific cardiac diseases 3. patient with neurologic disorders 4. patients on drugs that affect vasomotor tone of blood vessels
my body is fit and fabulous at school phase ii

Conditions: Overweight, Childhood

Summary: "my body is fit and fabulous" (mybff@school) program was designed specifically for overweight and obese school children in order to help them control their bmi and body fat. mybff@school is a multi-faceted obesity intervention program that incorporated physical activity, nutrition and psychology modules.

"my body is fit and fabulous" (mybff@school) is a school-based, cluster randomised controlled trial (c-rct) study that primarily aimed to evaluate the effectiveness of mybff@school program on overweight and obese school childrens' bmi for age (bmi z-score) and body fat percentage at 3 and 6 months post intervention. primary and secondary schools in the central region of peninsular malaysia were randomised to either intervention or control school via systematic random sampling method. the selected intervention schools underwent mybff@school programme that consisted of physical activity, nutrition and psychology modules, whereas the control schools followed the standard national school curriculum.

Eligibility criteria:
inclusion criteria: * give consent * overweight and obese students with bmi for age (bmi z-score) more than +1sd based on who 2007 growth reference * age between 9-16 years old exclusion criteria: * bmi for age below and equal +1sd * physical or mental disability * medical conditions that prevent him/her to participate in moderate-to-vigorous physical activity * co-morbidities that may interfere with the study such as: 1. diagnosed type 2 diabetes mellitus 2. hypertension 3. nephritic syndrome 4. epilepsy 5. congenital heart disease 6. skeletal anomalies * on steroids * on anti-epileptic * on methylphenidate
vascular effects of sertraline in heart failure

Conditions: Heart Failure; Depression

Summary: to determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression


Eligibility criteria:
inclusion criteria: * chronic heart failure with lvef\ 21 years * depression requiring medical treatment with sertraline exclusion criteria: * known intolerance of sertraline

Keywords: vascular endothelium nitric oxide depression heart failure vascular biology
voriconazole-induced qt interval prolongation: a prospective study

Conditions: Voriconazole Induced QT Interval Prolongation

Summary: the antifungal voriconazole is effective for the treatment of invasive fungal infections in immunocompromised patients. a serious adverse reaction is qt interval prolongation, which may precede life-threatening arrhythmias, such as torsades de pointes. although ventricular arrhythmias are mentioned as a possible adverse effect of voriconazole, thus far, the incidence and clear recommendations for qt follow-up have not been published. this prospective observational study aimed at describing the incidence of voriconazole induced- qt interval prolongation in the pediatric population and determine the risk factors for this phenomenon.


Eligibility criteria:
inclusion criteria: * oral or iv treatment with voriconazole exclusion criteria: * no data prior to initiation of voriconazole treatment on qt interval (baseline ecg) * renal insufficiency or dialysis treatment

Keywords: voriconazole, ecg, arrhythmia
post traumatic critical complications: a prospective cohort study (atlanrea)

Conditions: Severe Trauma (With or Without Traumatic Brain Injury)

Summary: the purpose of this observational epidemiological study is to investigate the management and the complications associated with severe trauma. data will be analysed to answer pre-defined scientific projects and to improve management of these conditions.

pseudonymized data will be collected by study coordinators in a secured e-database. cross audit will be performed to check data.

Eligibility criteria:
inclusion criteria: * severe trauma * and/or traumatic brain injury * and/or hemorrhage exclusion criteria: * consent withdrawal

Keywords: severe trauma traumatic brain injury hemorrhage
a study of the clinical safety, tolerability, and efficacy of zoledronic acid compared to an oral bisphosphonate

Conditions: Osteoporosis

Summary: the purpose of this trial is to study the clinical safety, tolerability, and efficacy of zoledronic acid compared to an oral bisphosphonate in postmenopausal women with osteoporosis.


Eligibility criteria:
inclusion criteria: * postmenopausal women between 45 and 79 years of age * must be osteopenic/osteoporotic exclusion criteria: * any women of child-bearing potential other protocol-defined inclusion/exclusion criteria may apply.

Keywords: osteoporosis, osteopenia, post-menopausal, zoledronic acid
digital technique to analyze the wear of implants and natural tooth as antagonist.

Conditions: Dental Prosthesis Failure

Summary: the aim of this study was to describe a novel digital technique to analyze the wear of screw-retained implant-supported metal-ceramic dental prostheses and natural tooth as antagonist. materials and methods: ten patients were consecutively included to rehabilitate partial edentulism by dental implants. both the screw-retained implant-supported metal-ceramic dental prostheses and the natural tooth as antagonist were submitted to a digital impression through an intraoral scan to generate a standard tessellation language digital file preoperatively (stl1), at 3 months (stl2), and 6 months (stl3) follow-up. afterwards, an alignment procedure of the digital files (stl1-stl3) was performed on a reverse engineering morphometric software and volume changes at the screw-retained implant-supported metal-ceramic dental prostheses and the natural tooth as antagonist were analyzed using student's t-test. moreover, gage r\&r statistical analysis was conducted to analyze the repeatability and reproducibility of the digital technique.


Eligibility criteria:
inclusion criteria: * in good health, who presented partial edentulism in the posterior upper maxilla, were consecutively included to rehabilitate partial edentulism by dental implants exclusion criteria: * all those who do not meet the inclusion criteria

Keywords: implant supported morphometry screw-retained digital wear
mirna (microrna) and fgf21 (fibroblast growth factor-21) profile in first trimester and gestational diabetes prediction

Conditions: Gestational Diabetes

Summary: the goal of this observational study is to compare mirna and fgf21 in pregnancy with and without gdm (gestational diabetes) the main question it aims to answer that mirna and fgf21 are different between two groups. participants will be retrieved blood sample during first trimester and undergone 100 gm ogtt (oral glucose challenge test) during 24-28 weeks of gestation.

pregnant women who attended antenatal care at maharaj nakorn chiang mai hospital during first trimester were recruited. participants received routine standard prenatal care except, 1. additional blood test during 11-13 week 6 days (blood was collected for further analysis) 2. performed 75gm ogtt during 24-28 week baseline data and pregnancy outcome were reviewed.

Eligibility criteria:
inclusion criteria: * singleton pregnant women who attend at our clinic in first trimester exclusion criteria: * known underlying disease such as chronic hypertension, pregestational diabetes, sle * normal structural fetal anatomical screening * incomplete obstetric data
improving lipid optimization quality and treatment options in ascvd

Conditions: Hypercholesterolemia; ASCVD

Summary: the goal of this project is to study different approaches to improve the utilization of guideline directed medicines to lower cholesterol in patients with or at high risk of atherosclerosis (cholesterol buildup in the arteries).

this project will include approximately 300 patients who, based on current guidelines, would benefit from optimized lipid management. the project is testing the most effective methods to notify providers and patients and inform them that their patients may benefit from further lipid optimization. it will utilize systematic allocation at the provider level in which clinicians are assigned to either the direct provider notification strategy or the pharmacist-driven medication management strategy, ensuring that all patients continue to receive guideline-based care while eliminating the risk of treatment selection bias. approximately 100 providers to ensure a sufficient number of patients are included.

Eligibility criteria:
inclusion criteria: * \>18 years old and \<=95 years old * established atherosclerotic cardiovascular disease * diabetes * possible familial hypercholesterolemia (fh) * high-risk primary prevention exclusion criteria: * no pcp, cardiologist, endocrinologist, or nephrologist at mgb * esrd on dialysis * enrolled in a hospice program * advanced dementia
effect of raisins on cognitive function in healthy older adults

Conditions: Cognitive Dysfunction

Summary: objective:to assess the effect of an intervention based on including 50 g of raisins (sultanas) daily in the diet for 3 months on improving cognitive performance, cardiovascular risk factors and inflammatory markers in a population of older adults without cognitive impairment. methodology: randomised two parallel-group clinical trial. population: 80 patients between 70 and 80 years of age will be included, selected from primary care clinics in salamanca and zamora. measurements and intervention: participants included in the study will have a baseline visit and two evaluations visits at 3 and 6 months where cognitive performance (attention, executive functions, verbal memory, working memory and language) will be assessed using a brief neuropsychological battery; quality of life, using the whoqol- age and euroqol-5d questionnaire; blood pressure; glycaemia; body composition, using an impedancemeter; and different markers of inflammation, interleukin (il) 6, il-1 and tumour necrosis factor alpha (tnf); and different markers of inflammation, interleukin (il) 6, il-1 and tumour necrosis factor alpha (tnf-α). participants will be randomised using the epidat 4.0 programme into 2 groups (control group and intervention group) with a ratio of 1:1. both groups will be instructed to continue with their usual dietary pattern without changing their habits during the study period. those in the control group will not receive any amount of raisins to their usual diet. the participants in the intervention group will receive 50 g of raisins and instructions on the time of day to take it (at night). the duration of this intervention will be 3 months. the daily nutritional intake of this amount of raisins is as follows: 146 kcal; 0.25 g of fat; 34 g carbohydrates of which 34 g sugars; 1.3 g protein; 1 g fibre. the total polyphenol content of total polyphenols from 50 g of raisinas is approximately 532,5 mg (phenols explorer database).


Eligibility criteria:
inclusion criteria: * people of both sexes aged between 70 and 80 years. * the score on the mini mental state examination (mmse) must be greater than or equal to 24 points. * self-employed to attend the centre where the study is carried out. * signature of the informed consent form. exclusion criteria: * coronary or cerebrovascular atherosclerotic pathology. * diabetes mellitus * grade ii or higher heart failure. * moderate or severe chronic obstructive pulmonary disease. * advanced renal or hepatic disease. * severe mental illness. * oncological disease under treatment diagnosed within the last 5 years or terminal condition. * morbid obesity (imc ≥ 40 kg/m2). * intolerance and/or allergy to any of the grape components. * any other circumstance at the criterion of the researchers.

Keywords: cognitive dysfunction heart disease risk factors vitis polyphenols clinical trial
efficacy of diazoxide in type 1 diabetes

Conditions: Diabetes Mellitus, Type 1

Summary: the purpose of this study is to find out if diazoxide can partly retain insulin production in newly diagnosed type 1 diabetes patients.

at the time of diagnosis most subjects with type 1 diabetes retain significant endogenous insulin secretion as assessed by c-peptide measurements. although not sufficient for the needs of the individual, residual insulin secretion is important for metabolic control, for avoidance of hypoglycemic episodes and, perhaps, for protection against diabetic complications. to retain residual endogenous insulin secretion in type 1 diabetes is thus highly desirable. residual insulin secretion deteriorates during the course of type 1 diabetes. the underlying autoimmune process is a major determinant of deterioration. however, also measures that do not directly target the immune system could be beneficial. the dcct study randomised subjects with type 1 diabetes to either intensive or conventional insulin treatment. the intensive insulin treatment markedly retarded deterioration in c-peptide levels during 5 years of observation. the favourable effect could be due to lesser hyperglycemia per se. alternatively, the effect of intensive insulin treatment could be secondary to lesser degree of over-stimulation of the patients' beta-cells. it is by now established that relief from over-stimulation by diazoxide favourably affects beta-cell function and that such treatment can retard a decline in residual insulin secretion in subjects with newly diagnosed type 1 diabetes. diazoxide has been used in clinical practice for \> three decades without major safety concerns. disturbing, albeit reversible, side effects are halting long-term studies with diazoxide in type 1 diabetes. the researchers find that lower and intermittent (i.e. night time) dosing of diazoxide produces no measurable side effects in subjects with type 2 diabetes. this is a double blinded placebo controlled study, with 35 participants with newly diagnosed type 1 diabetes are randomised into either placebo or diazoxide for 6 months. the patients will be followed up after intervention for at least 12 months. beta cell function and glycemic control will be monitored.

Eligibility criteria:
inclusion criteria: * type 1 diabetes no longer than three months * positive antibodies against gad or ia2 * age between 18-40 years * c-peptide \>0.2 nmol/l exclusion criteria: * drug or alcohol abuse * severe concomitant disease * pregnancy

Keywords: type 1 diabetes beta cell rest diazoxide insulin secretion
effectiveness of acapella and eltgol technique to promote airway clearance in copd:a comparative study

Conditions: Chronic Obstructive Pulmonary Disease

Summary: to compare the efficacy of acapella and expiration against open glottis (eltgol) technique in promoting airway clearance of chronic obstructive pulmonary disease (copd) patients

this study is carried out to determine the effectiveness of acapella and expiration in lateral position with open glottis to clear the secretion in copd patients. the sessions will be carried twice daily for twenty minutes. the outcome measures are values of pre and post intervention fev1/fvc and breathlessness cough sputum scale. duration of the study will be for five days.

Eligibility criteria:
inclusion criteria: * mild copd * moderate copd * patient able to sustain expiratory flow greater than 15l/min * patient expectorate more than 25.-30ml exclusion criteria: * severe copd * peripheral oxygen saturation lower than 85% * rr\>35breaths/min * current acute chest pain * recent history of haemoptysis