Kornimate/medical-research-clean huggingface dataset:
tele-rehabilitation in the home with gaming as a method of improving upper extremity function after stroke

Conditions: Stroke; Hemiplegia

Summary: the purpose of the study is to determine whether a novel computer gaming hand exercise regimen would improve hand and arm function and be feasible in people with hemiplegia after stroke affecting the hand.

a novel computer gaming hand exercise regimen has been designed for people with hemiplegia after stroke affecting the hand. the design allows a broad range of common objects of daily life to be seamlessly transformed into 'therapeutic' input devices by instrumenting with a small motion sense mouse. based on individual abilities and treatment needs, objects are selected to train specific fine/ gross dexterous functions. the object manipulations (therapeutic exercises) are then used to control and play any commercially available computer game, making practice challenging and engaging. the study is of twelve weeks duration comparing the computer gaming and conventional hand exercises in ten people with hemiplegia after stroke affecting the hand. the investigators hypothesize that the game based exercises will improve hand function and will be feasible. a mixed-effect repeated measures analysis of variance will be conducted to test pre to post treatment outcomes.

Eligibility criteria:
inclusion criteria: * time since stroke onset less than 1 year. * ability to actively extend at least 10 degrees at the metacarpophalangeal and interphalangeal joints and 10 degrees at the wrist. at least 30 degree of active flexion-extension at elbow and some active movements present at the shoulder joint. * english speaking. * no clinical evidence of cognitive impairment (screened by physician or therapist). * have a personal computer at home. * lives in winnipeg. * able to provide informed consent. exclusion criteria: * patients having excessive spasticity, pain or contractures in the more affected limb will not be included in the study. * convulsive seizures preventing adequate attention to task. * problem with vision. * aphasia. * apraxia.

Keywords: hand exercises hand function computer based exercises therapeutic gaming
mild resistive expiratory breathing technique on spinal cord injury

Conditions: Spinal Cord Injuries

Summary: studies have been conducted on the effectiveness of inspiratory muscle training on tetraplegics, and less has been reported on expiratory muscle training on paraplegics; especially in pakistan there was no such study done up-to my knowledge. paraplegic individuals develop pulmonary complications due to prolonged general immobilization of body and ineffective cough due to respiratory muscle weakness. this study will identify the effects of expiratory muscle training using "expiratory muscle strength trainer- 150" in paraplegic individuals in peshawar, pakistan

a study on the effects of accessory expiratory muscle training and showed that there was a significant improvement in vital capacity of experimental group. the investigator recruited 40 patients and randomly allocated them to control and experimental groups. experimental group received expiratory muscle training for half hour a day, six days a week for eight weeks, which included training using pflex muscle trainer. control group received conventional breathing exercises and assistance in coughing. experimental group showed improvement in mean vital capacity from 1.48 to 1.98 liters and in mean expiratory muscle strength from 43.76 cmh2o to 68 cmh2o. control group yielded no changes. a respiratory muscle training and electrical stimulation of abdominal muscles on thirteen quadriplegic individuals to assess their respiratory function. the study consisted of training the patients for three months. each subject was given one-month inspiratory training, followed by second month of expiratory muscle training, and then last month without training. vital capacity showed 19% increase in the experimental group while control group showed no improvement . a randomized controlled trial to assess the effect of expiratory muscle training on pulmonary function of 29 spinal cord injury patients in an acute inpatient rehabilitation hospital. patients were randomized into two groups. experimental group consisting of 16 patients received expiratory muscle training using emst for 10 repetitions twice a day, 5 days a week, for 6 weeks. control group consisted of 13 individuals and they received sham training. there was no significant difference reported between both groups

Eligibility criteria:
inclusion criteria: * spinal cord injury (level t1 and below) * paraplegic exclusion criteria: * rib fractures * active inflammation or infection going in body * diagnosed (primary lung diseases) * individuals with psychiatric disorders or malignancies

Keywords: pulmonary function test spinal cord breathing exercise expiratory
optimal doses of ergocalciferol supplementation for treatment of hypovitaminosis d in adults

Conditions: Vitamin D2 Supplementation in Vitamin D Insufficiency

Summary: to investigate the optimal initial and maintenance doses of vitamin d2 supplementation for the treatment of vitamin d insufficiency in thai adults, and to determine the prevalence of and risk factors for hypovitaminosis d among thai adults.

a double-blinded prospective, randomized study undertaken at outpatient clinic of king chulalongkorn memorial hospital. the patients with vitamin d insufficiency were included and divided into three groups according to their initial 25ohd concentrations. patients are randomly assigned to receive vitamin d2 40000, 60000 or 80000 iu once weekly. serum 25(oh)d levels are measured at 12 weeks after vitamin d2 supplemetaiton. the patients with 25ohd more than 30ng/ml are enroll into the maintenance phase of the study and are randomly assigned to receive vitamin d2 20000 or 40000 iu once weekly for another 12 months. the 25ohd concentration are measure again at the end of the study.

Eligibility criteria:
inclusion criteria: 1. adult age ≥ 15 years 2. bmi 18 - 35 kg/m2 3. serum 25(oh)d \< 30ng/ml exclusion criteria: 1. hypercalcemia, nephrolithiasis, or fractures 2. hepatic disease 3. kidney disease 4. granulomatous disease 5. currently supplemented with vitamin d
effects of video-assisted surgery on ventilatory parameters

Conditions: Surgery--Complications

Summary: the study investigates the effects of induced pneumoperitoneum during surgery on ventilatory parameters including peak inspiratory pressure, lung compliance, end-tidal co2 at specific time-points: after induction of anaesthesia, after induction of surgery, one-hour and two-hours during surgery, end of surgery. the effects of pneumoperitoneum are compared between two groups of patients: patients undergoing laparoscopic surgery and patients undergoing robotic-assisted surgery. no intervention was performed in this study and the decision for type of surgery performed was made by the attending surgeon prior to study inclusion


Eligibility criteria:
inclusion criteria: * patients who underwent video-assisted surgery by either classic laparoscopy or robotic-assisted surgery. exclusion criteria: * refusal to participate * conversion of surgery to laparotomy * need of vasopressure support * preoperative severe respiratory dysfunction
to assess safety and efficacy of bolus versus continuous infusion of terlipressin in acute variceal bleeding

Conditions: Acute Variceal Bleeding

Summary: the study is single centered; prospective, parallel arm randomized controlled trial.the patients will be who presented to institute of liver \& biliary sciences with esophageal variceal bleeding or develop esophageal bleeding during hospital stay. all patients will be managed with continuous non-invasive cardiac and hemodynamic monitoring including cardiac rhythm, pulse rate, blood pressure, and oxygen saturation. hemoglobin (hb) will checked every 6 h for the initial 48 h and then every 12 h till discharge. likewise, serum creatinine will checked daily. packed red blood cells will be transfused to maintain target hb of ⩾8 g/dl. patients will be started on iv proton pump inhibitor, with bolus dose of terlipressin (2mg) followed by endoscopic variceal ligation. all patients will received prophylactic antibiotics; antibiotics will be stopped if there will no other indication to continue. after confirmation of evb (esophageal variceal bleeding) and successful initial hemostasis with emergency evbl (endoscopic variceal band ligation), patients will be randomly assigned into group -a (bolus terlipressin at 2mg every 4hourly) and group-b (continuous infusion of terlipressin @ 4mg/24hour initially) therapy for esophageal varices . they will then undergo hvpg (hepatic venous pressure gradient) measurement at baseline, 12hours and 24hours. patient in continuous group will titrate dose. accordingly to hvpg (hepatic venous pressure gradient) measurement at 12 and 24 hours. at 24 hours patient will be directed to receive either tips (transjugular intrahepatic portosystemic shunt) or will continue terlipressin for 48 hours.


Eligibility criteria:
inclusion criteria: * any patient with only acute esophageal variceal bleeding (as defined by asian pacific association for the study of liver disease) * informed consent to participate in the study * age 18 to 70 years exclusion criteria: * pregnant and lactation * prior treatment with any vasoactive drugs * significant heart or respiratory failure * peripheral arteriopathy clinically significant * previous heart stroke or significant alteration of the electrocardiogram * hemodynamically unstable * refusal to participate in the study * hypertension
ed50 of cis-atracurium for laryngeal mask incubation in general anesthesia

Conditions: Urologic Diseases

Summary: 1. the muscle relaxants can improve the conditions of laryngeal mask incubation and reduce the related complications (such as laryngeal spasm and postoperative throat pain) 2. the dosages of muscle relaxants used in various researches vary greatly. 3. we are planning use the most classical method for determining the ed50 or half effective concentration of cis-atracurium using sequential method, which is also called " up and down method" and " ladder method".

the concordance of the current research is that muscle relaxants can improve the conditions of laryngeal mask incubation and reduce the related complications (such as laryngeal spasm and postoperative throat pain ) of laryngeal mask incubation. it is necessary to use muscle relaxants in laryngeal mask incubation under non-special circumstances. however, the dosages of muscle relaxants used in various researches vary greatly of normal endotracheal intubation. previous studies have shown that the amount of muscle relaxant required for laryngeal mask intubation is smaller than that required for endotracheal intubation. although the dosage of muscle relaxant required for tracheal intubation can ensure the smooth insertion of laryngeal mask airway, laryngeal mask airway is mostly used for short surgery, which is prone to postoperative muscle relaxation residue and prolongs the recovery. we planning use the most classical method for determining the ed50 or half effective concentration of cis-atracurium using sequential method, which is also called " up and down method" and " ladder method".

Eligibility criteria:
inclusion criteria: 1. asa ⅱ\~ⅲlevel; 2. bmi18.5-30； 3. those who intend to undergo short urological surgery ( operation time \< 1h ); 4. age 25\~75 years 5. estimated amount of bleeding \< 5ml / kg. exclusion criteria: 1. neuromuscular diseases or metabolic diseases; 2. preoperative complicated with water and electrolytes disorders ( such as hypokalemia and hypocalcemia ); 3. serious hepatic and renal insufficiency and serious heart and lung diseases; 4. predictable difficult airway; 5. take drugs ( such as aminoglycoside, polymyxin, phenytoin sodium, carbamazepine, etc. ) that affect the nerve-muscle transmission function or the efficacy of muscle relaxants before surgery; 6. muscle relaxation drug allergy; 7. previous history of alcoholism or drug abuse.
a study of torcetrapib/atorvastatin vs atorvastatin alone or placebo in patients with high cholesterol

Conditions: Hyperlipidemia

Summary: the torcetrapib project was terminated on december 2, 2006 due to safety findings. a study to look at lipid levels in subjects taking the study drug, atorvastatin alone or placebo.

for additional information please call: 1-800-718-1021

Eligibility criteria:
inclusion criteria: * subjects with elevated cholesterol exclusion criteria: * women who are pregnant or lactating, or planning to become pregnant. * intolerance to statin therapy resulting in withdrawal * subjects taking any drugs known to be associated with an increased risk of myositis in combination with hmg-coa reductase inhibitors * subjects with any other medical condition or laboratory abnormality which could affect subject safety, preclude evaluation of response, or render unlikely that the subject would complete the study
docetaxel plus carboplatin in treating patients with stage iiib or stage iv non-small cell lung cancer

Conditions: Lung Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining more than one drug may kill more tumor cells. purpose: phase ii trial to study the effectiveness of combining docetaxel and carboplatin in treating patients who have stage iiib or stage iv non-small cell lung cancer.

objectives: i. determine the effectiveness of low dose docetaxel and carboplatin by response rate, response duration, and time to progression in patients with stage iiib or iv non-small cell lung cancer. ii. determine the side effects and toxicity profile of docetaxel when given in combination with carboplatin in these patients. outline: this is open label study. patients receive docetaxel iv over 1 hour followed by carboplatin iv over 30 minutes once a week for 4 weeks. patients receive at least 2 courses (8 weeks) of treatment. courses are further repeated in the absence of unacceptable toxicity and disease progression. projected accrual: there will be 20-38 patients accrued into this study.

Eligibility criteria:
disease characteristics: histologically confirmed stage iiib with metastatic pleural effusion or metastatic stage iv non-small cell lung cancer large cell adenocarcinoma squamous cell bronchioalveolar carcinoma undifferentiated no small cell or carcinoid histologies at least 1 bidimensionally measurable or evaluable indicator lesion measurable or evaluable indicator lesion(s) must be completely outside the radiation portal or there must be proof of disease progression no current cns metastases at study entry no meningeal carcinomatosis patient characteristics: age: 18 and over performance status: zubrod 0-2 life expectancy: greater than 12 weeks hematopoietic: neutrophil count at least 1,500/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than upper limit of normal (uln) sgot and/or sgpt no greater than 2.5 times uln if alkaline phosphatase less than uln, or alkaline phosphatase no greater than 4 times uln if sgot and/or sgpt less than uln renal: creatinine clearance at least 50 ml/min other: no concurrent illness that would effect assessment of this study not pregnant or nursing effective contraception required of all fertile patients prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior systemic chemotherapy no other concurrent chemotherapy endocrine therapy: not specified radiotherapy: see disease characteristics prior radiotherapy for non-small cell lung cancer allowed radiotherapy for new brain metastases (other than leptomeningeal disease) is allowed during study, but chemotherapy is stopped during and for 2 weeks following radiotherapy concurrent radiotherapy to other sites allowed if there is no objective criteria for disease progression surgery: not specified other: no other concurrent experimental drug

Keywords: squamous cell lung cancer large cell lung cancer stage iiib non-small cell lung cancer stage iv non-small cell lung cancer adenocarcinoma of the lung
effects of peri partum integrated nursing care versus routine care in placenta previa : a randomized controlled trail

Conditions: Placenta Previa Total; Nursing Role

Summary: at our institution, the annual number of placenta previa was 494 cases (1.7%); of whom 95 cases (19.2%) were proved to have a placenta accreta. perioperatively, they are subjected to regular care of a tertiary university hospital. this study aims to determine the effectiveness of peri partum integrated nursing care for the patients with placenta previa versus routine care.

study design: experimental design: (randomized control trail) setting: this study will be conducted at woman's health hospital, assiut university, emergency department and inpatient department. sample: a convenience sample will be used, the total sample will include (100) patients with placenta previa, divided into two group1:1 * group 1: 50 patients study group * group2: 50 patients control group

Eligibility criteria:
inclusion criteria: * pregnant women with diagnosis of placenta previa. exclusion criteria: * other high risk pregnancy cases

Keywords: placenta previa nursing antepartum hemorrhage randomized trial
a study of amantadine for cognitive dysfunction in patients with long-covid

Conditions: Long COVID; Post-Acute COVID-19 Syndrome

Summary: purpose: to decrease symptom burden, improve cognitive function, improve endurance, and decrease fatigue in subjects with post-acute sequelae of covid-19 (pasc) or "long-hauler" covid using amantadine. if amantadine use is determined to be efficacious in this population, the findings of this study will be used towards a subsequent randomized control trial.

this study is a prospective, open-label, single-blind, randomized control study. study duration is approximately 6 weeks starting at the baseline visit. we will recruit 30 participants (15 per arm) for this pilot study.

Eligibility criteria:
inclusion criteria: * age 20-65 * can provide informed consent * confirmed covid+ test (either rapid antigen or pcr) between 8 weeks and one year prior to initial visit. * able to consent in english * endorse symptoms during their initial evaluation and history with the provider that began around the time of the acute covid19 infection (subjective) including cognitive changes such as cognitive fatigue, brain fog, memory issues,attention issues and have symptoms in at least 1 out of the 2 following symptom categories: * category 1: decreased endurance, physical fatigue, weakness * category 2: depression, anxiety exclusion criteria: * known hypersensitivity to amantadine * clinically significant psychiatric, neurologic, renal, hepatic, opthalmologic, cardiac impairment in the opinion of the investigators, including but not limited to: * psychiatric: * acute or chronic unstable axis i psychiatric illness * history of psychosis * severe depression patient health questionnaire-9 (phq-9) score \>= 20 * suicidality * neurologic: * epilepsy * cognitive dysfunction predating covid infection * history of delirium * neurologic conditions with agitation or confusion
validation study of noveos® system (hycor)

Conditions: Allergen-mediated IgE Allergy

Summary: background : the noveos® method is a chemiluminescent immunoassay used to provide quantitative detection of total ige and allergen-specific ige antibodies in human serum. the ige antibody assay has an essential place in the diagnosis of mediated ige allergies. this system could become an alternative to the techniques used today. noveos® uses a quick and convenient method to give results concerning the patient's sensitization profile towards allergens. the volume required for the assays is 4 μl (against more than 100 μl for current techniques), which is particularly important in pediatric and geriatric populations where it may be more difficult to take larger samples. noveos® also brings true autonomy. in fact, the incorporated reagents provide sufficient capacity for 8 hours of continuous testing. objective: validate the noveos® system as an allergy diagnostic tool, by estimating the sensitivity and specificity of the noveos® assays compared to the gold standard diagnostic represented by the clinical history and pt positive, for a panel of 20 allergens methods: this is a validation study of a new immunoassay method (système noveos®). the study includes : * a preliminary phase to familiarize the team with the use of the noveos® system. it is planned to analyze its technical characteristics: the precision, the sensitivity. eight allergens will be tested, on a cohort of 136 patients * a validation study of the technique as a diagnostic tool for allergy (sensitivity and specificity compared to the gold standard represented by clinical history and positive pt) and comparison between the new technique and the immunocap® system. twenty allergens will be tested prospectively, each on 50 cases and 10 controls. a single patient may be both a case for an allergen and a witness for another. for rare allergies, the blood database of the allergy service will be used, and affected patients will be contacted to request their non-opposition.


Eligibility criteria:
incinclusion criteria: * patient who is at least 6 years old * the patient must be an affiliate or beneficiary of a health insurance plan exclusion criteria: * patient refusing to take part in the study * patient participated in another study that may influence test results * the patient is in an exclusion period determined by a previous study * the patient is under the protection of justice, under guardianship or under curatorship * patient under antihistaminic h1 treatment preventing the achievement of prick-tests * the patient is pregnant * the patient is breastfeeding * the patient has a history of tumor, autoimmune, or immune deficiency pathology * the patient suffers from a hematological pathology (coagulation disorders, anemia) that could interfere with the blood test

Keywords: allergy diagnostic tool specific ige assays allergens
lipid profile in patients with severe sepsis or septic shock under strict or liberal glycemic control

Conditions: Septic Shock; Sepsis

Summary: study of the lipid metabolism under glycemic control in septic patients who got an university 14 bed icu. hypothesis: establish a relationship between lipid metabolism alterations and glycemic control or infusion of exogenous insulin

the investigators enrolled 69 consecutive patients with severe sepsis or septic shock and divided them in two different groups after randomization with sealed envelopes. one group called intensive glycemic control with glycemic levels been between 80 to 110 mg/dl with exogenous insulin. the other group called conventional glycemic control with glycemic levels been between 180 and 220 mg/dl. blood samples were collected at 0, 12, 24, 48 and 72 hours to measure hdl, ldl, total cholesterol, free fatty acids and oxidized ldl. clinical data as creatinine, p/f ratio, bilirubins, platelets, lactate, arterial blood gasometry were either monitored.

Eligibility criteria:
inclusion criteria: * all patients aged between 18 and 80 years old * with the diagnostic of septic shock or severe sepsis exclusion criteria: * pregnants, * previous diagnosis of any cancer, * diagnosis of leptospirosis, * diagnosis of aids.

Keywords: septic shock glycemic control icu lipid metabolism septic patients