Kornimate/medical-research-clean huggingface dataset:
smooth extubation with ketofol for induction of general anesthesia in laparoscopic drilling of polycystic ovary

Conditions: Smooth Extubation

Summary: the effect of ketofol, a combination of propofol and ketamine, on hemodynamics and airway response during induction of general anesthesia has been studied before. its effect on the smoothness of extubation has not been studied before. in the present study; we aimed to assess the effect of ketofol on the smoothness of extubation as regards, airway response, sedation score during suction and extubation and hemodynamic changes comparing it with propofol for induction of general anesthesia.

after securing intravenous access by a 20g catheter, intravenous premedication (midazolam 2 mg and 4mg ondansetron) was administered to all patients. standard asa(american society of anesthesiologists) monitoring (5-lead ecg, noninvasive blood pressure (nibp), and pulse oximetry) was applied to all the patients for the recording of heart rate (hr), nibp and oxygen saturation by a multiparameter monitor. induction of general anesthesia was achieved as follows: in group k (ketofol group), fifty three female patients received propofol (1mg/kg) plus ketamine (0.5mg/kg) at the induction of general anesthesia while in group p (propofol group), fifty three female patients received propofol (2mg/kg) only at the induction of general anesthesia. patients in both groups received fentanyl 2 ug\\kg and atracurium 0.5 mg\\kg. after tracheal intubation, general anesthesia maintained by isoflurane 1.5 volume % in 2 l\\min oxygen-air mixture 50:50 and atracurium 0.1 mg\\kg every 30 minutes, if needed. at the end of the surgery, inhalational anesthesia was stopped and reversal of the patients was done by injection of neostigmine 0.05mg\\ kg and atropine 0.01mg\\kg. hemodynamics (hr and mean arterial pressure ''map'') was assessed at 5 minutes interval from the time of reversal of muscle relaxant up to 30 minutes after extubation. the level of sedation during suction and extubation was assessed using observer assessment sedation score and the airway response under direct laryngoscopy to suction was noted by five-point scale. after 5 minute interval, the level of sedation and smoothness of extubation was noted by four-point scale.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists physical status ''asa ps'' class i and ii scheduled for laparoscopic drilling for polycystic ovary under general anesthesia. exclusion criteria: * from cardiac, hepatic, renal diseases, history of epilepsy * patient refusal. * known drug allergy.

Keywords: ketofol propofol laparoscopic drilling of polycystic ovary
cord blood microtransplantation for treatment of acute myeloid leukemia

Conditions: Safety Issues; Efficiency

Summary: discuss the effectiveness and safety of cord blood microtransplantation for treatment of acute myeloid leukemia

the investigators conducted a prospective, single center clinical trial to dissuss the outcomes and toxicities of hla-mismatched cord blood infusion after chemotherapy (microtransplantation) in older patients with acute myeloid leukemia (aml)

Eligibility criteria:
inclusion criteria: 1. de novo acute myeloid leukemia 2. age 60-80 exclusion criteria: 1. have no suitable donor or donor refused 2. patient refused to accept donor cells

Keywords: cord blood microtransplatation
globalsurg-covidsurg week

Conditions: Surgery; Covid19; Post-Op Complication

Summary: observational study to determine the optimal timing for surgery following sars-cov-2 infection and assess key global surgery indicators.

* prospective, observational international cohort study. * any hospital worldwide can participate (including hospitals that have not admitted sars-cov-2 infected patients). * all patients undergoing a surgical procedure in an operating theatre will be included. all consecutive eligible patients should be included. * 7-day data collection period, with follow-up at 30 days after surgery for each patient. however, no changes should be made to normal patient care/ follow-up pathways * primary outcome is 30-day mortality. * all collaborators will be included as pubmed-citable co-authors on resulting publications.

Eligibility criteria:
inclusion criteria * any operation (elective or emergency) done in an operating theatre by a surgeon. * all surgical specialties including: acute care surgery, breast surgery, cardiac surgery, colorectal surgery, general surgery, gynaecology, hepatobiliary surgery, neurosurgery, obstetrics, oesophagogastric surgery, ophthalmology, oral and maxillofacial surgery, orthopaedics, otolaryngology, paediatric surgery, plastic surgery, thoracic surgery, transplant surgery, trauma surgery, urology, vascular surgery. * day case surgery and inpatient surgery included. * any sars-cov-2 status (positive at any time, negative, not tested). * all ages including children and adults. exclusion criteria: minor procedures (full list will be available in the protocol).
a novel surgical strategy to reduce major complications in patients with necrotizing pancreatitis

Conditions: Acute Pancreatitis

Summary: the goal of this observational study is to compare patient outcomes between the groups of patients admitted before and after the full implementation of the novel surgical strategy in patients with necrotizing pancreatitis. the main question it aims to answer are: • the efficacy and safety of the novel surgical strategy to assess the efficacy and safety of the novel surgical strategy, all included patients were divided into two groups according to the timing of receiving treatment: 1) the early period group: patients admitted before january 2021 received the hybrid strategy of traditional and novel surgical strategies; and 2) the late period group: patients admitted during and after january 2021 received the complete novel surgical strategy.


Eligibility criteria:
inclusion criteria: consecutive patients older than 18 years with necrotizing pancreatitis were included. exclusion criteria: patients who met one or more of the following criteria were excluded: (1) had a past medical history of acute pancreatitis; (2) had drainage or surgery for pancreatic necrosis in other hospitals before admission to our institute; and (3) did not complete the treatment strategy owing to nonmedical reasons.
evaluation of a postcoital sponge on self-reported vaginal health parameters

Conditions: Vaginal Infection; Vaginal Discharge; Vaginosis; Sexual Dysfunction

Summary: liviwell has developed a product designed for postcoital semen absorption. previous studies have demonstrated the product rapidly absorbs semen, and leads to less symptoms of postcoital vaginal microbiome disruption such as vaginal odor and discharge. this study will investigate the study device, livi, in a broader clinical setting.

liviwell's consumer hygiene device is a post-coital vaginal insert called "livi". livi is comprised of an applicator, with a medical-grade polyurethane foam and retrieval string. it is designed to be inserted into the vagina after intercourse to absorb semen deposited into the vaginal canal. the result is a decrease in discharge/dripping and vaginal odor. the investigators also believe the device will lower vaginal ph, as the typical premenopausal vaginal ph is acidic (ph \~4), and semen has an alkaline ph (\~8). the resulting ph imbalance in sexually-active women not using male condoms had been shown to lead to vaginal odor, dripping, discomfort. furthermore, the risk of bacterial vaginosis (bv) is higher in women who are sexually active and not using male condoms. the investigators have additional studies planned to evaluate if the product lowers the risk of bv. the current study will be used to validate user needs requirements for the study device, understand ph changes after insertion, and evaluate change in symptoms of vaginal odor, discharge/dripping, and discomfort, common symptoms of vaginal microbiome disruption and bacterial vaginosis.

Eligibility criteria:
inclusion criteria: * over 18 (for ph subset, 18-45) * sexually-active with biological men * willing and able to use product * resides in continental usa * understands, reads, writes, and speaks english exclusion criteria: * currently pregnant or are trying to conceive * unable to use device due to poor motor function * unable to sign informed consent

Keywords: vaginal odor vaginal discharge postcoital dripping vaginal microbiome
compass course: efficacy study

Conditions: Breast Cancer

Summary: the compass course is an 8-session progressive structure that was developed based on theoretical and scientific evidence from psychology and occupational therapy. the goal of the intervention is to provide participants with information, tools, and support that help them move towards reclaiming a sense of self-grounded purpose in daily life. the study will use a convenience sample of breast cancer survivors to evaluate the efficacy of the compass course intervention.


Eligibility criteria:
inclusion criteria: 1. 25 years of age or older 2. completed treatment (such as chemotherapy, radiation, surgery) for stage 0, 1, 2, or 3 breast cancer at least 2 months prior to participating in the compass course intervention 3. english speaking 4. high school diploma or ged 5. able to see, hear, speak (with or without assistive devices) 6. able to provide own transportation to sessions 7. willing and able to commit to attend all 8 intervention sessions exclusion criteria (all self-reported): 1. stage 4 breast cancer or any other stage 4 cancer 2. actively receiving chemotherapy or radiation treatments for cancer. (however, patients may be on herceptin and/or endocrine treatment and participate in the study.) 3. history of neurologic disorder (such as stroke or brain injury) with residual impairments that likely interfere with learning 4. any medical condition (physical or mental health) that interferes with the performance of everyday activities and roles.
sleep, pain and quality of life in chronic pain patients

Conditions: Chronic Pain; Insomnia

Summary: the interventional study will have two main aims. first, to compare two interventions aiming to improve sleep in chronic pain patients. and secondly, to study the associations of sleep, mood, chronic pain and quality of life. half of participants will go through icbt intervention for insomnia and the other half will receive sleep hygiene education. additionally, the study will gather information which patients will benefit/will not benefit the tertiary pain clinic treatment when the outcome variable is the health-related quality of life (hrqol).

sleep disturbances associates closely with chronic pain. it now seems that sleep problems usually precede and maintain persistent pain. anxiety and worry frequently precede and associate with disturbed sleep and chronic pain. depression is usually a consequence of chronic pain. pain and depression disturb sleep further. these elements form a vicious circle where poor sleep is a critical driver. previous studies have shown that sleep disturbances are a major contributor to the poor health-related quality of life (hrqol) of patients with chronic pain.

Eligibility criteria:
inclusion criteria: * fluency in finnish exclusion criteria: * severe psychiatric conditions (e.g. scizopherenia)

Keywords: health-related quality of life anxiety pain intensity pain interference symptoms of insomnia
serratus anterior plane block versus thoracic paravertebral block.

Conditions: Rib Fractures; Analgesia

Summary: compare between serratus anterior plane block and thoracic paravertebral block in analgesia for patients with multiple rib fractures

the study will be conducted in a prospective randomised controlled. patients will be allocated into three groups control group: the patient will receive fentanyl patch 50 microgram tpvb group: the patient will receive thoracic vertebral plane lock 0.4ml/kg bupivacaine 0.1 25% will be administered. for continuous infusion catheter will be inserted . then a rate of 7ml / hour to max 10 ml / hour of bupivacaine 0.0625% sapb group,: patient will receive serratus anterior plane block 0.4ml / kg bupivacaine 0.125% will be injected to open the space then a catheter will be advanced for continuous infusion of 0.0625 % bupivacaine at 7 ml / hour

Eligibility criteria:
inclusion criteria: * asa 1_3 age 18_60 unilateral fracture ribs exclusion criteria: * drug allergy morbid obese opioid dependence patients refuse

Keywords: fracture rib tpvb sapb
facet versus trigger point injections for chronic neck pain

Conditions: Neck Pain

Summary: a) background chronic neck pain is a significant and common issue which is difficult to treat. tight bands of muscle (trigger points) can be a source of chronic neck pain and they are sometimes injected to manage chronic neck pain. however, these injections seldom lead to significant, long-lasting relief. in some cases, these trigger points may originate from injury or damage to a specific joint in the neck (the facet joint). treatment of this joint with cortisone injection may lead to improved pain relief and function. b) hypothesis by injecting the facet joint with cortisone, the pain associated with tight bands of muscle in the neck and shoulders will be relieved to a greater extent than that attained through trigger point injection. c) methods patients with neck pain will have a test to determine if any pain originates from the facet joint. among those who have significant pain from these joints, a comparison between the effect of cortisone injection into these joints versus injection into the trigger points will be evaluated. d) expected results and significance it is expected that injection with cortisone into the facet joints will lead to improved pain and function when compared to that attained from trigger point injection. in addition, the number of trigger points, and the pain and headache that originate from these trigger points, are expected to decrease with cortisone injection into the facets to a statistically and clinically significant extent. results from this pilot study will then influence the design of future trials into chronic neck pain treatment, leading to better clinical recommendations. a peer-reviewed publication and conference presentations will facilitate dissemination.


Eligibility criteria:
inclusion criteria: * between 18 and 65 years of age and able to speak and understand conversational english * primary diagnosis of chronic (\>6 months) mechanical / myofascial neck pain exclusion criteria: * those with significant cognitive decline or cognitive interference (as identified by the physician) will be excluded, as will those who have received radiofrequency ablation of any cervical nerve within the past year, intra-articular cortisone facet injection within the past 4 months, trigger point injection into the cervical/shoulder girdle muscles within the past 4 months, or the presence of any known contraindication to injection (attachments). * women who are or may be pregnant (based on last menstruation) will be excluded. * finally, for the purposes of this pilot study, those currently involved in active litigation regarding the neck pain will be excluded. those with active worker's compensation claims or currently receiving salary indemnity benefits through motor vehicle insurance providers will be included, as they represent a significant proportion of this population.

Keywords: neck chronic pain facet injection
physiology of helmet vs. facemask noninvasive ventilation

Conditions: Acute Hypoxemic Respiratory Failure

Summary: the optimal noninvasive management of acute hypoxemic respiratory failure is debated. helmet noninvasive ventilation may be more effective than facemask noninvasive ventilation for these patients. putatitve benefits of helmet use are the possibility to apply significantly higher positive end-expiratory pressure without air leaks and with good patient's comfort. in this randomized crossover study, the investigators will assess the physiological effects of helmet compared to facemask noninvasive ventilation, with the latter applied with different ventilator settings (similar to or different from helmet settings).


Eligibility criteria:
inclusion criteria: * acute hypoxemic respiratory failure and pao2/fio2\<200 mmhg * paco2\<45 mmhg * respiratory failure not caused by exacerbation of chronic pulmonary disease, cardiac failure or fluid overload exclusion criteria: * pregnancy * contraindication to helmet or facemask noninvasive ventilation * contraindication to esophageal manometry * contraindication to electrical-impedance tomography monitoring * recent surgery involving the abdomen or the thorax * pneumothorax or documented barotrauma
dynamics of risk perception and risk behavior in alcohol use disorder and schizophrenia

Conditions: Alcohol Use Disorder (AUD); Schizophrenia and Related Disorders

Summary: the hyper- or hypo-attribution of risks is deeply related to the core pathological mechanisms of mental disorders and at the same time engaging in risky behaviors influences their course and outcomes. the investigators study risk perception, risk behaviors and underlying brain mechanisms in a longitudinal design in three groups of psychiatric patients who participate in a psychological intervention that is aimed to reduce risk behavior and increase risk perception. patients with schizophrenia (sz), alcohol use disorder (aud) and both disorders (sz + aud) are recruited during psychiatric in-patient treatment and participate in a combined face-to-face and mobile intervention that starts before release and ends four weeks after discharge. the standardized 4-session face-to-face group intervention that is based on motivational interviewing (miller \& rollnick, 2013) and relapse prevention (marlatt \& donovan, 2005) and addresses the reduction of disorder-specific risk behaviors, i.e. alcohol use for aud and sz+aud and medication non-adherence for sz. after discharge, a 4-week ecological momentary intervention (emi) supports participants to maintain abstinence from risk behaviors and to strengthen coping in high-risk situations relying on mental contrasting and implementation intentions (oettingen \& gollwitzer, 2011). participants will be assessed in fmri and behavioral measurements and by self-report pre and post interventional phase, furthermore they participate in an ecological momentary assessment during the post-discharge phase which assesses risk behaviors, high-risk situations and risk perception in real life contexts.


Eligibility criteria:
inclusion criteria: * for patient groups: fulfilling the diagnostic criteria for aud or sz or both exclusion criteria: for patient groups and healthy control group: * no sufficient command of german language * neurological disorder for patient groups: * acute psychotic episode * acute suicidality or not distanced from self-harming behaviors * other substance use disorder (exception: nicotine and caffeine use disorders) for healthy control group: * absence of any psychiatric diagnosis (exception: nicotine and caffeine use disorders)
stem cell therapy to improve the muscle function of patients with partly denervated muscles of the arm

Conditions: Brachial Plexus Injury

Summary: the purpose of this study is to assess muscle improvement after stem cell injection in the biceps muscle of patients with a brachial plexus injury.

brachial plexus injuries can cause severe disabilities and often affect young adults and newborn children. when initial conservative treatment or nerve surgery fails, muscle/tendon transfers are the only current treatment options available to regain a functional arm. during this extensive surgery a healthy donor muscle is transposed to exert a different function. after long-term denervation the muscle is irreversibly changed. muscle atrophy, fattening, fibrosis, decrease in capillary to muscle fiber ratio and decline in the number of satellite cells, which are responsible for post-natal muscle repair, is seen. for neuromuscular diseases, cell therapy aiming at rescuing muscle damage by delivery of cells that can differentiate into skeletal muscle, might be a promising approach. safety questions remain whether stem cell injection results in non-muscle tissue formation like inflammatory cells or connective tissue formation in the transplanted muscles. furthermore, it remains to be determined whether these stem cells undergo functional integration and enhance muscle function. the objective of this pilot study is to assess functional and morphological improvement of the m. biceps brachii after autologous bone marrow-derived mononuclear cell injection.

Eligibility criteria:
inclusion criteria: * bp patients with paresis of m. biceps brachii (mrc 1,2,3), either after conservative treatment or at least two years after nerve surgery with partial recovery of the elbow flexor * patients capable and willing to give informed consent exclusion criteria: * function recovery of the elbow flexor (m. biceps brachii) to a mrc motor scale of 0 * emg activity: no motor unit potentials * medical history of other central of peripheral neurological disorders * inability to undergo bm harvesting * bleeding diathesis, inr \> 2

Keywords: brachial plexus muscle denervation stem cell transplantation bone marrow cells satellite cells fibrosis
phase i study in rad 001 patients with relapse aml

Conditions: AML

Summary: a phase i clinical study in evaluation of rad 001 with aracytine and daunorubicine in aml treatment of patients older less than 65 years in relapse

the primary objective of the study is to determinate the maximal tolerate dose and evaluate the toxicity of rad 001 in patients older less than 65 years in aml relapse in association with a conventional chemotherapy 5aracytine and daunorubicine) in an dose escalated phase i study.

Eligibility criteria:
inclusion criteria: * patients from 18 to 65 years old * aml in relapse more than 1 year after cr * inform consent signed exclusion criteria: * age more than 65 * cardiac insufficiency * renal insufficiency * hepatic disease * other type of aml * blastic mcl * hiv positive serology * other malignancy * pulmonary infection

Keywords: rad 001 in relapsed aml