Kornimate/medical-research-clean huggingface dataset:
the influence of postoperative postures on persistent sub-foveal fluid after scleral buckle surgery

Conditions: Retinal Detachment

Summary: the purpose of this study is to evaluate whether postoperative postures influence persistent sub-foveal fluid after scleral buckle surgery

in this study, we are to compare the difference of influence of two postoperative postures on the incidence and duration of persistent sub-foveal fluid after scleral buckle surgery for macula-off retinal detachment

Eligibility criteria:
inclusion criteria: * rhegmatogenous retinal detachment (rrd) * macula off * treated by successful scleral buckle surgery * recent onset with symptom within 1 month exclusion criteria: * with failed previous surgery * intraoperative or postoperative injection of long-acting gas * with other eye diseases than rrd

Keywords: macula-off retinal detachment scleral buckle persistent sub-foveal fluid postoperative postures optical coherence tomography (oct)
a program to evaluate riastap® and fibtem® for the early control and treatment of postpartum hemorrhage (perfect pph)

Conditions: Postpartum Hemorrhage

Summary: in this prospective, single-center, randomized, placebo-controlled, double-blind clinical trial, parturients with primary pph are eligible for treatment with fibrinogen concentrate following both vaginal delivery and cesarean section complicated by an estimated blood loss (ebl) \>1000 ml and an ongoing bleeding notwithstanding standard treatment measures (volume replacement, uterine massage, and uterotonic agents).

the proposed trial targets early detection and treatment of fibrinogen depletion in pph. a widespread belief in the benefits of early fibrinogen substitution in cases of pph has led to an increased use for this indication. the perfect pph aims to provide an evidence-based knowledge for the recommendation of the early use of fibrinogen concentrate in pph.

Eligibility criteria:
inclusion criteria: * informed consent from participant * age ≥18 years and \<50 years * primary pph defined as bleeding from uterus and/or the birth canal within 24 hours postpartum * vaginal delivery or cesarean delivery (irrespective of etiology of pph, such as accreta), with ebl \>1000 ml and ongoing bleeding notwithstanding standard treatment measures (volume replacement, uterine massage, uterotonic agents) * fibtem®- a10 \<18 mm (corresponding to a mcf value of \<20 mm and to a plasma fibrinogen level approximately \<3 g/l) exclusion criteria: * refusal to give written informed consent * refusal to receive blood transfusion * known inherited deficiencies of coagulation * personal history of thrombosis * either pre-pregnancy or ante-partum antithrombotic treatment due to increased risk of thrombosis * administration of platelets, ffp or cryotherapy prior to study drug

Keywords: fibrinogen concentrate coagulation
predictive ability of peep induced changes in cvp to predict volume responsiveness in mechanically ventilated patients after major abdominal surgery

Conditions: Surgery; Critical Illness; Cardiac Output, Low

Summary: interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.

interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.

Eligibility criteria:
inclusion criteria: * mechanically ventilated and sedated patients admitted to the icu after major abdominal surgery exclusion criteria: * heart failure nyha iii or more * severe obstructive or restrictive lung disease * hypotension with map \< 60 mmhg * tachycardia \> 140 beats / min
leucine supplementation in elderly men

Conditions: Sarcopenia; Atrophy; Aging

Summary: in the present study the investigators aim to determine whether leucine supplementation can augment muscle mass and strength and improve body composition in healthy elderly men


Eligibility criteria:
inclusion criteria: * living independently exclusion criteria: * diabetes cardiovascular disease orthopedic limitations history of resistance training in past 5 years
oxaloacetate pharmacokinetics and safety

Conditions: Alzheimer's Disease

Summary: by doing this study, researchers hope to learn how much oxaloacetate (oaa) ends up in the blood after oaa capsules are swallowed, and to assess whether persons with alzheimer's disease who take oaa for one month have any side-effects.


Eligibility criteria:
inclusion criteria: * meet criteria for mild or moderate ad * have a study partner * speak english as primary language. exclusion criteria: * absence of a study partner * report a potentially confounding, serious medical risk such as type 1 diabetes, cancer, or a recent cardiac event (i.e. heart attack, angioplasty, etc.)

Keywords: oxaloacetate oaa ad alzheimer's disease
chronical illness-related limitations of the ability to cope with rising temperatures, third wave

Conditions: Coronary Disease; Myocardial Infarction; Heart Failure; Arrhythmias, Cardiac; Peripheral Artery Disease; Stroke; Ischemic Attack, Transient; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Pulmonary Disease, Chronic Obstructive; Asthma; Renal Insufficiency; Depressive Disorder; Anxiety Disorders; Schizophrenia; Peripheral Nervous System Diseases

Summary: the climate-iii observational study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and benefit perception, self-efficacy, health literacy, and the degree of urbanisation of the patients' administration district are associated with these effects. study participants from germany and italy will be included in the sample.

the climate-iii observational study aims to analyse to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, self-efficacy, or other factors are associated with these effects. this cohort study is based on an online survey of patients with chronic illness who are recruited in general practitioner (gp) practices in germany and italy. after the baseline assessment, participants fill out symptom diaries on 12 specific days of observation over a maximum period of 12 weeks. the specific days of observation are selected based on the maximum temperature that can be expected within the respective weeks. the weather forecast will be checked every monday. if, in the upcoming 4 days, the maximum temperature is expected to exceed 30°c, the warmest day in this time frame will be chosen. otherwise, the weather forecast will be checked again on thursday to choose the warmest of the remaining days of the week. on each day of observation, patients are notified by email at 6 pm. baseline assessment includes socio-demographic data, chronic diseases, somatosensory amplification, perceived risk for adverse health effects of heat, intention to implement protective behaviour, perceived benefit of this behavior, self-efficacy, and health literacy. local data on temperatures and humidity will be provided by the meteorological services of germany and italy. data will be analyzed by multivariable, multilevel regression analyses adjusted for possible confounders and random effects on the administration district and practice within administration district level.

Eligibility criteria:
inclusion criteria: * being 18 years or older * at least one of the following conditions: coronary heart disease; myocardial infarction; heart failure; cardiac arrhythmias; peripheral artery disease; stroke; transient ischemic attack; diabetes mellitus (type 1 or 2); chronic obstructive pulmonary disease; asthma; renal insufficiency; depressive disorder; anxiety disorders; schizophrenia; peripheral nervous system diseases. exclusion criteria: * no capacity to consent * severe visual impairment * insufficient german language skills * not able to use internet browser (eg, lack of hardware)
perioperative analgesic modalities for breast cancer surgeries

Conditions: Analgesia

Summary: the incidence of breast cancer is among women world wide, detection increased with introduction of mammography as a screening tool. surgical resection of breast cancer contributes to the generation of acute and chronic post mastectomy pain. this study aims at comparing the effect of erector spinae block versus serratus block versus intravenous morphine in patients undergoing modified radical mastectomy for breast cancer surgeries regarding pain control and possible side effects

one of the most common types of cancer affecting women is breast cancer. surgical resection is one of the main approaches applied for solid tumors. surgical approach for breast cancer involve the breast region. various analgesic modalities are used for proper perioperative pain control. morphine has always been considered as the gold standard analgesic, however opioids have multiple side effects. several loco-regional techniques have been introduced for breast surgery pain management including serratus plane block (spb) and erector spinae plane (esp) block. in this study the investigators are comparing the effect of erector spinae block versus serratus block versus intravenous morphine in patients undergoing modified radical mastectomy for breast cancer surgeries regarding intraoperative and postoperative analgesia, time to first analgesic, any possible side effects

Eligibility criteria:
inclusion criteria: * female 18-65 years old patients undergoing modified radical mastectomy exclusion criteria: * patient refusal, local infection at site of block coagulation defect abnormal kidney or liver functions
effect of covid-19 on hypertension

Conditions: COVID-19; Hypertension

Summary: in this single center , retrospective study, 5355 covid patient were selected from 2020 to 2022, with recorded blood pressure before covid and recording after covid. blood pressure before and after covid were compared, by pair t test.

design and participants this single-center retrospective cohort study was conducted at an outpatient cardiology clinic in shiraz, iran, between february 15, 2020, and december 28, 2022. we evaluated patients with a confirmed diagnosis of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection by rna reverse-transcriptase polymerase-chain-reaction assays from nasopharyngeal or oropharyngeal swab specimens according to world health organization guidelines (12). two physicians (pa, my) reviewed the patients' electronic medical records, including demographics, comorbidities, vital signs, treatments, and outcomes. ambiguities were resolved by a third author (mm). the current study included all covid-19 patients who had at least one documented blood pressure measurement in the three months preceding infection and one documented measurement one to three months following recovery. the following patients were excluded: those under 18, with hospital admission due to covid-19, who received corticosteroid therapy, those with a history of systemic inflammatory disease, kidney or liver, immunocompromised patients, and those who switched their antihypertensive regimen during the study. finally, 5,355 eligible patients were investigated . the primary outcome was to assess bp variation following infection (particularly a prolonged rise in bp) among non-hospitalized covid-19 patients. the secondary outcome was to identify the predictor factors of bp variation. the present study was approved by the ethics committee of shiraz university of medical sciences under code ir.sums.med.rec.1401.465 , and the need for informed consent was waived due to the study's retrospective nature and the absence of patient identifiers in the presented data.

Eligibility criteria:
inclusion criteria: * all covid-19 patients who had at least one documented blood pressure measurement in the three months preceding infection and one documented measurement one to three months following recovery exclusion criteria: * age under 18 * hospital admission due to covid-19 * corticosteroid therapy, * history of systemic inflammatory disease * kidney disease * liver disease * immunocompromised patients

Keywords: covid-19 hypertension blood pressure
clinical evaluation of effectiveness and safety of amberen and smart b by women with climacteric syndrome

Conditions: Climacteric Syndrome; Menopause

Summary: to evaluate effectiveness and safety of combined use of dietary supplements amberen and smart b by women with a typical (without complications) form of climacteric syndrome, with mild to moderate symptoms.

1. to evaluate effectiveness of combined use of dietary supplements amberen and smart b (vs placebo) by women with a typical (without complications) form of climacteric syndrome, with mild to moderate vegetative symptoms during perimenopause and menopause in regards to vasomotor, endocrine-metabolic, and neuro-psychological dysfunctions; 2. to evaluate safety of combined use of dietary supplements amberen and smart b (vs placebo) by women with a typical (without complications) form of climacteric syndrome, with mild to moderate vegetative symptoms during perimenopause and menopause, lasting no less than 1 year in regards to vasomotor, endocrine-metabolic, and neuro-psychological dysfunctions; 3. to develop recommendations for combined use of dietary supplements amberen and smart b for women with a typical (without complications) form of climacteric syndrome, with mild to moderate vegetative symptoms during perimenopause and menopause (menopausal for at least 1 year).

Eligibility criteria:
inclusion criteria: * female patients, 42-60 years of age; * patient with diagnosis of "climacteric syndrome", in typical or non-complicated form, mild or moderate vegetative symptoms during menopause i.e. absence of menstrual period for at least 1 year; * ability to read and understand informed consent form for the study's participation; * patients without risk factors and changes in the breast tissue based on the mammogram; * patients with medical history of risk factors without changes in the breast tissue; * ability to adhere to the conditions of the study. exclusion criteria: * presence of female reproductive system cancers (breast cancer, cervical cancer etc.); * presence of extragenital oncological conditions, except those in complete remission for 5 years or more; * conditions requiring emergency or planned hospitalization in the next 6 months; * presence of hormonally-active extragenital endocrine diseases (thyroid, adrenal, pituitary, hypothalamus); * surgical interventions done on sex organs or breasts, 1 year or less prior to the screening; * any surgeries done less than 3 months prior to the screening; * patients receiving hrt; * psychiatric conditions; * diabetes; * total ovariectomy * patients taking any other dietary supplements that can affect climacteric syndrome within the last month before enrolling in the study * high risk of non-compliance

Keywords: succinate b complex vitamins menopause
the impact of virtual reality on the emotional state of patients with aphasia during rehabilitation.

Conditions: Aphasia; Virtual Reality; Emotional Disturbances

Summary: the aim of the study is to determine virtual reality (vr) impact during standard program of rehabilitation on emotional state of patients with aphasia.

aim 1: to test the safety of virtual reality in a vulnerable population of patients with aphasia during rehabilitation. participants will be alternately assigned to receiving a relaxation session in vr every working day during a standard course of rehabilitation. aim 2: to test the preliminary efficacy of combining vr with the course of rehabilitation to promote emotional improvements in patients with aphasia.

Eligibility criteria:
inclusion criteria: * mild or moderate aphasia of any type * russian is primary language * at least 2 weeks post cardio-vascular accident (ischemic or hemorrhagic stroke) or head injury of any location * have a history of only one stroke * medically stable exclusion criteria: * associated severe cognitive deficits and psychiatric disorders which prevent patients understanding of the informed consent * epilepsy * medical history of severe visual or hearing impairment * comorbid neurological diagnosis (e.g. epilepsy, multiple sclerosis, parkinson disease, dementia) * unable to perform the required exercises due to severe motor, sensory or cognitive deficit (memory, attention, executive functioning, apraxia, regulatory and planning activities etc.) and medical problems (for example, anyone meeting new york heart association class iv criteria, hospitalization for myocardial infarction or heart surgery within 120 days, severe cardiomyopathy or documented serious and unstable cardiac arrhythmias) * drug or alcohol addiction within the last 6 months. * significant current psychiatric illness defined as affective disorder unresponsive to medication or bipolar affective disorder, psychosis, schizophrenia or suicidality * current participation in another interventional trial
comparative study of laparoscopic versus open appendectomy in children

Conditions: Appendicitis

Summary: the study intends to compare the results of two surgical methods to remove the appendix in children with appendicitis. specifically, up to 500 children over 3 years will be placed in two groups where the only difference in treatment is open or laparoscopic (scope) operation. each group will be tracked for their baseline characteristics, events during operation and recovery, pain medication requirements, duration of hospital stay, and patient/family satisfaction. the investigators hypothesize that their will be no difference in the parameters measured between the techniques of appendix removal.


Eligibility criteria:
inclusion criteria: * all children under the age of 18 years with diagnosed appendicitis exclusion criteria: * refusal of consent * primary language other than english or spanish.

Keywords: appendicitis laparoscopy randomized trial children pediatric
to investigate effects gsk561679 on part of the body's system that controls the balance of many of the hormones.

Conditions: Depressive Disorder and Anxiety Disorders

Summary: a study to investigate the effects gsk561679 on part of the body's system that controls the balance of many of the hormones (including cortisol).


Eligibility criteria:
inclusion: * healthy male subjects * non-smoker * normal ecg exclusion: * shift workers * vegetarians * persons who travel distances * persons participating in a psychology or psychiatry course

Keywords: hpa axis, healthy volunteers hormones, gsk561679, cortisol,
a pivotal study to evaluate the efficacy of lorundrostat in subjects with uncontrolled hypertension on a standardized antihypertensive medication regimen

Conditions: Hypertension

Summary: a phase 2 trial to evaluate the blood pressure-lowering effect of lorundrostat an aldosterone synthase inhibitor (asi), administered as an add-on to a standardized anti-hypertensive (aht) medication regimen, in subjects with hypertension.

this study is a phase 2 trial to evaluate the blood pressure-lowering effects of lorundrostat (an asi), administered as add-on to a standardized anti-hypertensive (aht) medication regimen, in subjects with hypertension. the study consists of a standardized aht regimen run-in period followed by a randomized, double-blind, placebo-controlled, parallel arm period. following the double-blind period subjects may be offered the opportunity to participate in an open-label extension (ole) study. subjects electing to not participate in the ole will undergo an end of study (eos) visit approximately 2 weeks after the last dose of study drug to complete their participation in the study.

Eligibility criteria:
inclusion criteria: 1. at least 18 years of age at the time of signing the informed consent form 2. at screening: aobp sbp of 140-180 mmhg and aobp dbp of 65-110 mmhg, or aobp dbp of 90-110 mmhg 3. 24-hour average abpm sbp of 130-180 mmhg or 24-hour average abpm dbp \>80 mmhg 4. taking between 2 and 5 aht medications, inclusive, at screening visit. 5. bmi of 18-40 kg/m2 inclusive at screening exclusion criteria: 1. egfr \<45 ml/min/1.73 m2 at screening, calculated using the chronic kidney disease epidemiology collaboration (ckd-epi) formula 2. serum potassium \>5.0 mmol/l at screening or \>4.8 mmol/l at randomization 3. serum sodium \<135 mmol/l at screening 4. history of heart failure, myocardial infarction, stroke, or transient ischemic attack within 6 months prior to screening. 5. diabetes mellitus with a glycosylated hemoglobin (hba1c) \>9% (\>74.9 mmol/mol) at screening

Keywords: blood pressure uncontrolled hypertension hypertension hypertensive resistant hypertension
iranian intensive care unit (icu) glutamine study

Conditions: Trauma Patients in ICU

Summary: this is a double-blinded placebo-controlled block randomized study in intensive care patients comparing enteral glutamine supplementation to placebo. the hypothesis is an improvement of clinical and paraclinical outcomes. the primary endpoint is infection probability score (ips) and systemic inflammatory response syndrome (sirs). anthropometric measures and serum inflammatory mediators will be compared.


Eligibility criteria:
inclusion criteria: * age 18-60 * no corticosteroids use * no history of heart, liver and kidney diseases * nutrition through nasogastric or orogastric exclusion criteria: * patients who will not tolerate enteral nutrition for more than 48 hours * patients who are npo and nutritional support has not started * lactating and pregnant women * kidney failure during the study * a history of glutamin supplement use before the study
impact of eating beans on metabolism

Conditions: Overweight

Summary: the purpose of this research is to test how eating a meal containing beans impacts how participants' bodies use food for energy.

the objective of this project is to test whether consuming a whole food that naturally contains resistant starch (rs), such as pulses, increases fat oxidation. the primary hypothesis is that consuming a rs-rich meal in which the rs is derived from a whole food (i.e., pinto beans, pinto bean flour) will increase postprandial fat oxidation to a greater extent than consuming a meal low in rs but containing the same amount of energy and macronutrient content.

Eligibility criteria:
inclusion criteria: * bmi \>18.5 or \<30 kg/m2 * ability to understand and sign the consent form * ability of transportation (i.e., participants must be able to provide their own transportation to the grand forks human nutrition research center) * non-smoking or use of other tobacco products, including e-cigarettes * not taking steroid-based medications; not planning to or currently attempting to gain or lose weight * all females of childbearing age must be on birth control for a minimum of 3 months prior to start of study exclusion criteria: * inability or unwillingness to consume any food item in the test meals * more than a 10% change in body weight within the past 2 months * participation in a weight loss diet/exercise program * current or planned pregnancy * lactation * uncontrolled hypertension (systolic \>160 mmhg or diastolic \>100 mmhg) * diagnosed cardiovascular, pulmonary, skeletal and metabolic diseases * fasting glucose \> 100 mg/dl or non-fasting (1-2 hours after eating) \>140 mg/dl * using medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants) * non-english speaking