Kornimate/medical-research-clean huggingface dataset:
quality of information provided during antenatal consultations

Conditions: Congenital Anomalies; Prematurity; Antenatal Consultation

Summary: the objective of this questionnaire study is to evaluate the concordance between the information provided to parents during antenatal consultations and their subsequent experiences following childbirth.


Eligibility criteria:
inclusion criteria: * patients were observed at the multidisciplinary prenatal diagnosis centre. * patients who had attended at least one antenatal consultation with a pediatric neonatologist * patients who gave birth between january 2020 and december 2022 and whose newborn was hospitalized in the neonatology department exclusion criteria: * a child who died in hospital or had a condition with a high risk of death in the first few years of life * non-french speaking mothers * mothers who were minors at the time of the study

Keywords: antenatal antenatal consultation information
decision support system on emergency triage

Conditions: Triage; Emergencies; Decision Support Systems

Summary: the objective of this study is to design a computer-based decision support system (dss) using the esi (emergency severity index) and ats (australasian triage scale) algorithms, integrate it into the hospital information management system (hims), evaluate the effect of the triage management in the emergency department and ensure the continuity of the system.

background: triage in the emergency department overstrains employees due to patient density, diversity, and time pressure. aim: the objective of this study is to design a computer-based decision support system (dss) using the esi (emergency severity index) and ats (australasian triage scale) algorithms, integrate it into the hospital information management system (hims), evaluate the effect of the triage management in the emergency department and ensure the continuity of the system. study design: this is a quasi-experimental study with a single-group pre-test and post-test design. the study consisted of three stages. methods: in the first stage, a sql (structured query language) script was developed to evaluate the accuracy and duration of pre-and post-dss triage decisions. in the second stage (pre-test), the accuracy and duration of pre-dss triage decisions were evaluated. in the second stage, a dss was prepared with rule-based decision trees method using the esi and ats algorithms and was integrated into the hims. in the third and last stage (post-test), the effect of the developed emergency triage decision support system (etdss) on triage management was evaluated against the accuracy and duration of triage decisions.

Eligibility criteria:
inclusion criteria: data of adult patients who applied to the adult emergency department and whose triage record was opened by a triage nurse. patient data with no probable or definitive diagnosis of covid-19. exclusion criteria: data of pediatric trauma patients (under 18 years of age) patient data for which the triage record was opened by non-nursing healthcare professionals patient data recorded in triage by nurses who did not receive atkds, emergency nurse triage, esi, ats training data of patients who applied with a probable/definite diagnosis of covid-19 and underwent pcr testing patient data in the date range when extraordinary changes were made in the adult emergency department patient triage area and evaluation process due to the covid 19 pandemic and the developed system could not be used (must use the sb covid algorithm)
rfviii-fc (produced by aryogen pharmed co.) pharmacokinetic study

Conditions: Severe Hemophilia A

Summary: the study is designed as a randomized, two-armed, double-blind, single-dose, crossover, two-sequence, active-controlled, multi-center, bioequivalence clinical trial with a primary endpoint of dose-normalized area under the curve (dnauc last)


Eligibility criteria:
inclusion criteria: * male patients ≥ 12 years, with signed informed consent by the patient, or the patient's legally authorized representative for patients under the legal age * diagnosed with severe hemophilia a (endogenous fviii \<1% \[1 iu/dl\]) * history of at least 150 documented prior exposure days to any fviii product * having adequate bone marrow and organ function: * plt ≥ 80,000 cells/µl * hb ≥ 8 mg/dl * egfr ≥ 30 ml/min * alt or ast ≤ 5×uln * serum bilirubin ≤ 1.5×uln exclusion criteria: * measurable anti-drug antibody activity against fviii (≥ 0.6 bu/ml) at screening or a history of developing anti fviii antibody * history of other coagulation disorders except for hemophilia a * acute hemorrhagic state * infection with hcv or hbv * hiv-positive patients * infusion of any products containing fviii within 7 days prior to first administration * previous treatment with commercially available extended half-life fviii products * receiving drugs which increase bleeding tendency (e.g: anti-coagulants, antiplatelets, omega 3, vit e, etc.) within 2 weeks of screening. nsaids are permitted. * current systemic treatment with immunosuppressive drugs * hypersensitivity or anaphylaxis associated with any fviii concentrate or intravenous immunoglobulin (ivig) * planned elective surgery * current enrolment or willing to enroll in any other experimental study during the time of current trial * subjects assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol (e.g.: physical, psychological and mental problems)
comparison of ards covid-19 (who) vs ards influenza in the icu

Conditions: ARDS; COVID-19 Acute Respiratory Distress Syndrome; Influenza

Summary: since the beginning of the sars cov 2 pandemia, the sars cov 2 was frequently compared with the seasonal influenza virus. however, few studies compared patients presenting acute respiratory distress syndrome (ards) induced by these viruses, with results being discordant. our study means to compare mortality and morbidity of patients hospitalized in an intensive care unit (icu) with ards induced by sars cov-2 and seasonal influenza.


Eligibility criteria:
inclusion criteria: * patients hospitalized in icu * under mechanical ventilation * presenting an ards according to the berlin definition * induced by either influenza or sars cov 2 exclusion criteria: * pregnant women * mechanical ventilation\>48 hours before admission

Keywords: ards
postoperative pain and bacterial reduction in oval canals after instrumentation with different noval rotary files systems

Conditions: Bacterial Count Reduction in Oval Canal After Rotary Instrumentation With Different Systems; Post-operative Pain After Rotary Instrumentation of Oval Canal With Different Systems

Summary: postoperative pain after endodontic treatment can affect a patient's quality of life. it is reported that debris extrusion after the instrumentation technique can influence postoperative pain. as a result, the aim of this clinical trial is to compare the recent rotary systems (trunatomy, protaper ultimate, hyflex edm and xp- rise rotary files systems) in terms of apical extrusion defined by post-operative pain and their role in reducing the bacterial count inside the canal

one hundred and twenty lower premolar teeth will be included in the study(n=120). teeth will be randomly assigned to one of the 4 groups(n=30). preoprative pain will be recorded before root canal treatment. postoperative pain will be recorded using visual analogue scale (vas) at 6 hours,12 hours, 1day, 2 days, 3 days, 4 dayse and five days after the root canal treatment. bacterial count before and after instrumentation will be determined using culturing methods to determine the bacterial count reduction.

Eligibility criteria:
inclusion criteria: * medically fit * age ranges from 18-65 year * restorable teeth * necrotic teeth and symptoms free * lower premolars teeth (single canal posterior teeth) * necrotic pulps exclusion criteria: * medically compromised * non-restorable teeth * open apex canal * the past 12-hour history of analgesic intake before treatment. * patients with a history of antibiotics intake in the last 3 months before treatment. * pregnant females. * symptomatic patient. * pulpal diagnosis is not necrotic pulp. * retreatment cases

Keywords: post operative pain protaper ultimate hyflex edm xp rsie trunatomy bacterial oval canal
family risk analysis of substance use in attention deficit hyperactivity disorder (adhd) youth treated with concerta

Conditions: ADHD; Smoking

Summary: the researchers will study 100 families over three years, each with a child (proband) between the ages of 12-17, with the diagnostic and statistical manual of mental disorders, fourth edition (dsm-iv) diagnosis of adhd. the researchers hypothesize smoking will be familial and adhd probands with a family history of tobacco use will be at increased risk for early initiation and persistence of smoking, compared to adhd probands with no family history of tobacco use.

as attention deficit hyperactivity disorder (adhd) is a documented risk factor for smoking in adolescents, and as theoretical considerations suggest that adhd and tobacco use may share common underlying mechanisms, the proposed study looks to examine the association between smoking and adhd. since both adhd and smoking are known to be familial disorders, one approach to examine the nature of the association between the two disorders is to conduct a familial risk analysis comparing adhd youth who smoke and adhd youth who don't smoke. another approach is to conduct a genetic study, to identify candidate genes associated with nicotine abuse and dependence in adhd youth and relatives. this study includes: 1. assessment of psychopathology and substance use/dependence, 2. assessment of the family environment, and 3. assessment of molecular genetics in 100 families with at least one child (proband) between the ages of 12-17 with a dsm-iv diagnosis of adhd.

Eligibility criteria:
inclusion criteria: * first-degree relative between the ages of 6-55 years of a family member (proband) between the ages of 12-17 with the dsm-iv diagnosis of adhd

Keywords: adhd smoking familial risk
utrecht cohort for lung cancer outcome reporting and trial inclusion (u-color)

Conditions: Lung Cancer

Summary: objective: 1) to collect information on patient characteristics, short- and long-term clinical and patient-reported outcomes; and 2) to create an infrastructure for efficient, fast, and pragmatic randomized evaluation of new interventions. study design: observational, prospective cohort study, according to the 'twics' design. study population: all patients with lung cancer referred to the department of pulmonology or the department of radiotherapy of the umc utrecht. main study parameters/endpoints: clinical parameters (performance status, co-morbidity, oncological history, symptoms, imaging, technical and treatment data), clinical endpoints (toxicity, reintervention and survival), and patient-reported outcomes.

the prospective u-color cohort (utrecht cohort for lung cancer outcome reporting and trial inclusion), aims to: * gather data on natural disease progression, treatment response, disease recurrence, complications, quality of life and survival of patients with lung cancer; * collect a patient group willing to participate in studies; * facilitate multiple, parallel randomized controlled trials within the cohort.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years; * radiographic and/or histologic proof of lung cancer; * referred to department of pulmonology or the department of radiotherapy for treatment. exclusion criteria: * mental disorder or cognitive dysfunction that hinders the patient's ability to understand the informed consent procedure and/or study details; * patients with severe psychiatric disorders; * inability to understand the dutch language.
cardioinsight 2 - non-responder

Conditions: Heart Failure

Summary: background cardiac resynchronization therapy (crt) is proven to improve survival and heart function of patient with certain electrical conduction abnormality and heart failure. however, in patient with certain electrical conduction abnormality, being nonresponder is observed in up to 40% in patient receiving crt. conventionally the surgical approach of crt is to implant one pacing lead in the right heart and one in the left heart to resynchronize the contraction and the pacing lead in the left heart is usually placed in the posterior or lateral portion of the left heart. however, this single approach may not be optimal, especially for those patients with conduction abnormality known to have no response to crt. purpose of the clinical investigation. the purpose of the electrical activation guided crt for nonresponders study is to study the effectiveness of an addition of hisbundle pacing approach to crt nonresponder by direct his-bundle pacing to improve the responder rate of nonresponder of conventional crt and a tailored made approach to crt procedure by using a noninvasive globally mapping system studying the electrical conduction under different approaches to delivery crt. the pacing approach that optimally corrects conduction abnormality will be determined before the actual addition of new lead procedure. conduct of the investigation this study will include 18 patients already implanted with device delivering conventional crt that known to have no response to the conventional crt after 6 months of the crt therapy from prince of wales hospital, hong kong. you will be followed in the device clinic as per usual care after your participation in the study is completed.


Eligibility criteria:
inclusion criteria: * adult (aged 18 or above) of both sexes * ischemic or non-ischemic cause of heart failure * qrs duration \> 120 ms, non -lbbb type of conduction disturbance * nyha class iii or above * informed consent by the patient * already received stable dose of guideline directed medical therapy for at least 3 months exclusion criteria: * lbbb patients * pregnant women * participation in another study * patient with contraindication to left ventricle catheterization by a retrograde aortic approach
influence of coffee on the health and on the heart of normal, diabetics e coronary artery disease patients

Conditions: Coronary Artery Disease

Summary: coffee is a worldwide drink, been part of any culture. there are some concerns about effects of coffee on the health. recently, epidemiological studies have shown benefits of coffee drinking to diabetics and also to prevent diabetes in populations. we aim to understand some effects of coffee and not only caffeine over vascular system, in special coronary artery disease patients, diabetics end normal people.

patients will have a wash-out period (21 days) with no coffee or other caffeine-drinks. then they will be submitted to treadmill test, mapa, holter-ecg and vascular reactivity study, biochemical and inflammatory plasma dosages, as basal. then they will start a period of coffee drinking over 4 weeks; and all exams will be repeated. we will study two types of coffee, arabica and robusta; with two types of toasted beans(regular and soft). also regular and decaffeinated coffee. a total of 300 (100 normal people, 100 diabetics, 100 coronary disease) individuals will be tested.

Eligibility criteria:
inclusion criteria: normal volunteers: 1. healthy volunteer. 2. age between 20 and 80 years. 3. no addict to drugs. 4. absence of chronicle diseases. 5. no alcohol abuse. 6. no smoker. coronary artery disease: 1. presence of coronary artery disease, by coronary angiography 2. stable angina, class 1-3 of ccs. 3. age between 20 and 80 years. 4. treadmill effort test with ischemia. 5. no alcohol abuse. 6. no smoker. diabetes: 1. presence of type ii diabetes on oral treatment. 2. age between 20 and 80 years. 3. absence of chronicle diseases, except diabetes. 4. no alcohol abuse. 5. no smoker. exclusion criteria: normal volunteers: 1. any blood test with twice or more the upper limit range. 2. presence of enlarged qrs. coronary artery disease: 1. any blood test with twice or more the upper limit range even with treatment. 2. presence of enlarged qrs. 3. ventricular dysfunction (ef \< 45%). diabetes: 1. blood glucose greater than 160 mg/dl. 2. others blood tests with twice or more the upper limit range even with treatment. 3. presence of enlarged qrs.

Keywords: coronary artery disease coffee heart system
a retrospective egfr mutation status study in chinese nsclc patients using paired plasma and tissue samples

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: egfr mutations plays an essential role in egfr-tkis treatment. however, for some patients, tissue samples are not available. the purpose of this study is to determine whether blood sample is feasible for egfr mutation detection.for late stage nsclc, we hypothesis plasma sample is an alternative for detecting egfr mutations.


Eligibility criteria:
inclusion criteria: * non-small cell lung cancer * available plasma and pathologically confirmed tissue slices(pre-chemo and pre-radio therapy) * informed consent exclusion criteria: * n/a

Keywords: carcinoma, non-small-cell lung erbb-1
the effect of simulation-based preoperative nursing care education on student

Conditions: Preoperative Care; Nursing Education; Simulation; Clinical Practice

Summary: today, different technologies are used in the stages of the education and training process. simulation education approaches constitute an important group in health education and training. simulation in nursing education; provides experience-based learning opportunities and enables students to develop their clinical decision-making skills. the aim of this study is to determine the competence status and influencing factors of students who continue their nursing education at the faculty of health sciences of a foundation university regarding preoperative nursing care. this randomized controlled study will be conducted with students who continue their nursing education at the faculty of health sciences at a foundation university on the anatolian side of istanbul in the 2023-2024 academic year. the research data were obtained with an introductory questionnaire, perceived competence scale for preoperative nursing care, kolb learning styles inventory iii, stai state and trait anxiety scale. before the data collection process, ethics committee approval and institutional permission were obtained, the purpose of the study was explained to the students and an informed consent form was filled out. students who agreed to participate in the study filled out the relevant survey questionnaires and scale questions. the aim of this study is to determine the effect of simulation-based education to be given to nursing students on their perceived competence status and anxiety levels regarding preoperative nursing care. this randomized controlled study will shed light on future studies.


Eligibility criteria:
inclusion criteria: * -2023-2024 students actively continuing their undergraduate nursing program at the faculty of health sciences * students who volunteered to participate in the research were included in the research exclusion criteria: * students who have graduated * those who did not volunteer were not included in the study
assess differences in pain following cryo and radiofrequency atrial fibrillation ablation

Conditions: Atrial Fibrillation

Summary: the primary objective is to assess any differences in patient quality of life between cryo balloon ablation and radiofrequency ablation in the treatment of atrial fibrillation. the study will also assess any differences in the amount and duration of pain medication required after the ablation.

currently there are several different accepted techniques for performing ablation of atrial fibrillation. the two primary techniques currently in use in our center for atrial fibrillation are cryo balloon and radiofrequency ablation. based on personal observation, it is felt that patients undergoing radiofrequency ablation have a higher incidence of chest discomfort and subsequently a greater requirement for pain medications post procedure as compared to those patients undergoing cryo ablation.

Eligibility criteria:
inclusion criteria: * paroxysmal atrial fibrillation who are advised either cryoablation or radiofrequency ablation for treatment. exclusion criteria: * persistent atrial fibrillation * pregnant * taking pain medications for acute or chronic conditions at the time of the procedure. * undergo a combination of cryoablation and radiofrequency ablation * radiofrequency group who undergo ablation beyond pulmonary vein isolation
a study to investigate the clinical responses in ankylosing spondylitis patients on adalimumab therapy in taiwan (east)

Conditions: Ankylosing Spondylitis (AS)

Summary: the objectives of this prospective observational study is to explore 1-year clinical response via both bath ankylosing spondylitis disease activity index (basdai) and ankylosing spondylitis disease activity score (asdas) after initiation of adalimumab therapy in as patients from routine clinical practices in taiwan.


Eligibility criteria:
inclusion criteria: * participants with confirmed as. * participant will start adalimumab as treatment * participant must provide the written authorization form and agree to provide personal and/or health data prior to the entry into the study. exclusion criteria: * participant has been treated with any investigational drug or biologic within a minimum of 30 days or five half-lives (whichever is longer) of the drug prior to the baseline visit. * participants who fulfill any of the contraindications as per humira label in taiwan.

Keywords: ankylosing spondylitis (as) adaliumumab humira