Kornimate/medical-research-clean huggingface dataset:
music intervention for agitation reduction in the pediatric intensive care unit

Conditions: Critical Illness

Summary: the objective of this study is to administer music therapy to patients in the pediatric intensive care unit (picu) in order to observe how music affects patient agitation, vital signs, and overall recovery in the unit.

this study is a prospective randomized controlled study to observe patients who have been admitted to the picu with an altered state of agitation according to the richmond agitation sedation scale (rass). these patients will be administered music therapy during a controlled setting in the day to observe whether the introduction of music therapy helps reduce the patient's level of agitation, improving their vital signs and overall recovery in the unit. once patients are enrolled and have signed consents, patients will receive a headset with music or dead air. therapy times will be selected so that there are minimal disruptions. total time will be 2 hours daily, once in the morning and once in the evening. the treatments for session 1 and session 2 of the day will be the same (i.e. music/ music, no music/no music). the investigators hypothesize that applying music therapy in the picu will decrease agitation, length of stay, and narcotic administration, and normalize heart rate, respiratory rate, and blood pressure.

Eligibility criteria:
inclusion criteria: * picu patient at oishei children's hospital of buffalo * \>4 years of age, \<18 years of age * patients with rass of +1 exclusion criteria: * documented underlying psychological disorders * diagnosed with sever developmental delay * prior narcotic dependence * underlying medical conditions affecting heart rate, blood pressure, or neuromuscular system * chemically paralyzed patients * anyone with an aneurysm * patients who are deaf in both ears * ear bone fractures or other middle/inner ear trauma or major ear avulsion as determined by physician * hemodynamically unstable patients * patients facing imminent death

Keywords: picu critical care music music therapy agitation
a pilot study of functional optical coherence tomography for ocular imaging

Conditions: Glaucoma; Diabetic Retinopathy; Age-Related Macular Degeneration; Central Retinal Vein Occlusion; Branch Retinal Vein Occlusion

Summary: growing evidence shows that altered blood flow plays a major role in many vision-threatening diseases including glaucoma, diabetic retinopathy, age-related macular degeneration, central retinal vein occlusion, and branch retinal vein occlusion. optical coherence tomography, an established imaging technique use for eye exam in clinical ophthalmology, provides high-resolution cross sectional images of the retina and has increased our ability to understand many eye diseases.

optical coherence tomography is a non-invasive technique use a broadband light source to illuminate the area of study with light in the near infrared spectrum, then obtains static images of tissue structure from interference signals of the back-reflected light. optical coherence tomography a non-contact, non-invasive means of documenting both tissue structure and blood flow changes in ocular disease and can provide high resolution cross-sectional images of tissue structure, direct visualization of blood flow in blood vessels of the eye.

Eligibility criteria:
inclusion criteria: * adult 18 years and older with normal eye, or has been diagnosed with eye disease. exclusion criteria: * less than 18 years of age.

Keywords: eye exam retina
the effects of surgery for painful external snapping hip

Conditions: Hip Pain

Summary: the purpose of this study is to assess the pain-relieving effects of surgery for painful external snapping hip.


Eligibility criteria:
inclusion criteria: * patients undergoing surgery for painful external snapping hip * 18 years or older exclusion criteria: * inability to comply with the protocol (e.g. due to dementia)
the effect of tactile deficit on motor function in unilateral cerebral palsy

Conditions: Cerebral Palsy; Rehabilitation; Tactile Perception

Summary: cerebral palsy(cp) is the most common cause of disability in childhood. the motor spectrum of disorders is characterized by abnormal muscle tone, posture, and movement. the motor disorders of cp are often accompanied by disturbances of sensation, perception, cognition and behavior. besides classical appearance of symptomatology, tactile impairment takes an important place to be evaluated. assessment of the integrity of tactile function composes of two main steps: tactile registration and tactile perception. our main goal is the define the effect of tactile impairment on hand motor function with the usage of identical assessment tools in patients with unilateral cerebral palsy (ucp) and typically developed children (tdc).


Eligibility criteria:
inclusion criteria: * ages between 5-15 years * being evaluated as class i-ii-iii in gross motor function classification system * being evaluated as class i-ii-iii in manual ability classification system exclusion criteria: * inability to understand and/or follow test instructions due to intellectual or behavioral difficulties * history of upper extremity botulinum toxin type a injection in the last three months, * previous upper extremity orthopedic surgery * history of major trauma, and visual impairment
targeting emotion dysregulation to reduce suicide in people with psychosis

Conditions: Psychosis; Suicide

Summary: people with psychotic disorders are excluded from most suicide-focused clinical trials despite incredibly high rates of completed suicide, and interventions that have been tested for this population have shown limited impact on suicide. emotion dysregulation is a significant suicidogenic factor that is understudied in people with psychotic disorders. the investigators propose to implement and evaluate an intervention targeting emotion dysregulation in people with psychotic disorders while employing rigorous statistical modeling and measurement techniques including ecological momentary assessment, which will support future advanced research on suicide and suicide prevention for this high-risk group.


Eligibility criteria:
inclusion criteria: * at least 18 years old * psychosis spectrum disorder as assessed by the mini international neuropsychiatric interview (mini) for psychotic disorder studies * heightened suicide risk as determined by a score of 8+ on the suicide behaviors questionnaire-revised (sbq-r). this cutoff may be revised downwards (toward lower suicide risk) if recruitment appears difficult, but will not be revised upwards. * enrollment and engagement in outpatient mental health services with at least one mental health service in the previous month * 6+ grade equivalent reading level as assessed by the wide range achievement test 4 (wrat-4) exclusion criteria: * chart diagnosis of intellectual disability (dsm5 317, 318), traumatic brain injury, or deafness.
learning early infant feeding cues

Conditions: Responsive Feeding; Infants; Weight Gain Trajectory

Summary: the goal of this clinical trial is to learn more about responsive infant feeding (recognizing baby's signs of hunger and fullness) in mothers and infant enrolled in government-funded maternal-child home visiting programs. the main questions it aims to answer are: * what are the contributors and barriers to use of responsive infant feeding? * how can we refine an intervention focused on responsive infant feeding (the learning early infant feeding cues intervention) so that mothers will like it and learn skills to help their baby be healthy. * will the refined intervention improve use of responsive feeding and be feasible and acceptable to mothers and home visiting programs? participants will be asked to: * participate in focus groups to talk about their experiences feeding their baby. * participate in a study to learn about responsive feeding and how to use it with their baby. this study will start when mothers are in their final month of pregnancy and finish when their baby is 6 months old. participation will include: * having someone come to the family home during a time when the baby is eating (either from the breast or the bottle). the mother will receive information on the baby's signs from an experienced coach. * agreeing to be video recording during the session when the baby is eating. * completing surveys online.


Eligibility criteria:
maternal inclusion criteria * pregnant mother in the 3rd trimester (28 weeks or beyond) * enrolled in a government-funded maternal-child home visiting program * maternal age 18 years or older * english or spanish speaking * anticipated to have custody of infant after birth * healthy pregnancy, no complications that are anticipated to result in a preterm birth or extended hospital stay for mother or infant maternal exclusion criteria * gave birth to multiple fetuses * age less than 18 years * not fluent in english or spanish * expected to not have custody of the infant after birth infant inclusion criteria * born as a singleton (not a twin, triplet, etc.) to a mother enrolled in a maternal-child home visiting program * born full term (37 weeks or beyond) infant exclusion criteria * congenital anomaly that may interfere with infant feeding or growth after birth (i.e., down syndrome, cleft lip/palate) * born preterm (born prior to 37 weeks) * nicu stay beyond 48 hours * infant diagnosis of failure to thrive * supplemental oxygen * enteral feeding device used for feedings
study of brain tumors (tectal tumors) using magnetic resonance imaging

Conditions: Tectal Plate Glioma

Summary: tectal plate gliomas are relatively rare tumors of childhood with a reported incidence of 10%. their typical clinical presentation is symptoms and signs of hydrocephalus and are often incidentally diagnosed in the imaging work-up of children with hydrocephalus. tectal tumors in children comprise a subcategory of brainstem tumors with unique clinical, imaging, and spectroscopic features. there is debate whether they truly represent brainstem tumors or whether they are a site of benign cellular overgrowth. the majority of these tumors are pathologically benign and show no or minimal growth. not all tectal plate tumors, however, have this typically benign course. some can manifest a more aggressive behavior. there have been reports in the past attempting to analyze the histology and behavior of these tumors. none of the prior series looking at these tumors have included magnetic resonance spectroscopy (mrs) analysis. it is interesting that according to where tumors occur in the brainstem usually indicates what their histology and behavior is. although not absolute, we know that tumors can have a very poor prognosis versus an extremely good prognosis depending on their location in the brainstem. yet there are always the cases that do not act in the typical fashion and this is where mrs can prove helpful. this study is being done to look at a region of the brain, called the tectal plate, in children. this part of the brain can be involved by tumors. because of the location of the tectal plate, it is usually very difficult and risky to get a biopsy (tissue sample) from this area. magnetic resonance spectroscopy (mrs) is a non-invasive imaging technique that can look at the chemical make up of the brain. mrs may allow us to better understand the nature and behavior of these tumors. however, in order to understand disease in this area, we need to look at the normal chemical make up of the brain in children without tectal plate tumors. healthy patients are being asked to participate as a normal volunteer. we anticipate having a total of 10 to 12 normal volunteers in the mrs study.


Eligibility criteria:
inclusion criteria: * patients who are already scheduled for a brain mri at children's healthcare of atlanta at scottish rite for reasons other than tectal plate glioma evaluation exclusion criteria: * patients with tectal plate glioma

Keywords: tectal plate glioma tumor brain mri spectroscopy
fri a method of reading cardiotocography (ctg) in labor

Conditions: Labor Complication

Summary: the objective of the study is to investigate the fri's ability to identify cases requiring urgent intervention which will present an adverse perinatal outcome (respiratory acidosis, metabolic acidosis, apgar index, etc.) compared to the classical interpretation of ctg. patients whose ctg in labor will be considered non-reassuring will be enrolled and randomized into two groups. the "fetal reserve index" algorithm will be applied to the first group of patients. the second group of patients will, however, be managed according to the usual protocols internal management.

patients in active labor and diagnosed with category ii ctg will be enrolled and randomized into two groups. full randomization will be performed by excel software by generating random numbers using the "randomise (rand)" function the "fetal reserve index" algorithm will be applied to the first group of patients. in in these patients the fetal reserve index will be calculated every 10 minutes. at each of the components of the score will be assigned a score of 1 if the variable evaluated is considered normal, 0 if classified as abnormal. the different scores obtained (score from 1 to 8) will be classified into 3 risk categories: score 5-8: green zone, score 3-4: zone yellow, score 1-2: red zone. an fri of 1-2 (red zone) is to be considered as anomalous. for patients with abnormal fri a 40 minute timer will be started within which it will be necessary to exit the "red zone". if such patients will not be able to exit the red zone within 40 minutes, an additional timer will be started of 30 minutes within which the birth will be completed. the birth will be completed immediately in case of sentinel events (prolonged bradycardia, detachment of placenta, cord prolapse). the second group of patients will, however, be managed according to the usual protocols internal management.

Eligibility criteria:
inclusion criteria: * women in the active phase of labor who presented when they entered the room i delivered a negative admission test (i.e. a normoreactive ctg according to acog) and that subsequently present during labor a diagnosis of category ii ctg * single term pregnancy * signature of informed consent exclusion criteria * failure to sign the informed consent * previous caesarean section (tolac) * twin pregnancy * gestational age \<37 weeks * known genetic/chromosomal syndromes and/or malformations, excluding heart disease without contraindication to vaginal birth exclusion criteria: -
interpretation bias as a mechanism of treatment response in ocd

Conditions: Obsessive-Compulsive Disorder

Summary: this study will conduct a randomized controlled trial of cognitive bias modification for interpretation (cbm-i) as an augmentation to treatment as usual for obsessive compulsive disorder (ocd). cbm-i is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with cbm-i. adults with obsessive compulsive disorder (ocd) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive: 1) up to 12 sessions of cbm-i, or or up to 12 sessions of psychoeducation as a control condition.


Eligibility criteria:
inclusion criteria: * 1) ocd institute patients * 2) adults (\> 18 years old) * 3) able to complete a computer task for 20 minutes * 4) consent to main ocd institute study protocol * 5) primary diagnosis of ocd (as measured by a score of \>16 on the y-bocs and a clinical diagnosis of ocd by their treatment team * 6) score of \>131 on the obsessive beliefs questionnaire-44 at admission \[which is 1 sd above the mean score of the non-clinical sample reported in the original validation paper by the obsessive compulsive cognitions working group (2005)\] exclusion criteria: * 1) currently experiencing acute symptoms of psychosis * 2) psychotic disorder diagnosis
clinical effectiveness of exposure based cognitive behavioral group therapy for ibs

Conditions: Irritable Bowel Syndrome

Summary: the aim of the study is to evaluate the effects of a specific cognitive behavioral treatment protocol for patients with ibs used in routine care at a gastroenterology unit in stockholm. the research question is whether the treatment has the same effects in routine care as it has had in efficacy studies. the treatment is given by licenced psychologists (with cbt training) face-to-face in groups of 4-7 participants and lasts for ten sessions (ten weeks, normally).

ibs is a debilitating condition that affects approximately one out of eleven persons world wide. it is often called a functional disorder, a term used to characterize painful conditions, whose biological mechanisms are not fully understood. diagnosis is made based on symptoms and exclusion of other conditions rather than specific tests or biological markers. treatment usually starts with diet counselling and a change of eating habits. if symptoms persist, a physician can prescribe medication of different types. but for some patients neither change of diet, nor medication is sufficient. some of these patients may benefit from psychological treatment. there are a few different psychological treatments that have been proven efficacious in clinical trials. most researched is cognitive behavior therapy (cbt). our study is a clinical effectiveness trial without a control group. the data comes from a gastroenterology clinic in stockholm and is collected as part of the work with continous improvement at the clinic. patients with diagnosed ibs are offered group treatment with a specific cbt protocol developed by our research group at karolinska institutet. the treatment comprises 6 different modules and stretches over ten sessions. the modules are: 1. information regarding the treatment, ibs and mindfulness. 2 hypervigilance and anxiety. 3. behaviors and thoughts. 4. behavior change part one - toilet habits including exposure to feared situations. 5. behavior change part two - exposure to symptoms and avoidance/control behaviors. 6. summary and relapse prevention. group sizes range from 4-7 patients and the treatment is given by licenced psychologists who are employed at the clinic.

Eligibility criteria:
inclusion criteria: - diagnosed with ibs exclusion criteria: * severe psychiatric condition (for example severe depression, self injuring, psychosis, ptsd) * unable or unwilling to participate in group therapy

Keywords: cognitive behavior therapy, ibs, group therapy, exposure,
gcc19cart for patients with metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: study ict-gcc19cart-us-001 (carapia-1) is a phase 1 study evaluating the safety, tolerability, clinical activity, pharmacokinetics and pharmacodynamics of gcc19cart in subjects with relapsed or refractory metastatic colorectal cancer.


Eligibility criteria:
inclusion criteria: * adults \> 18 years old * clinical and histopathological diagnosis of metastatic colorectal cancer * guanylate cyclase (gcc) positive disease as determined by immunohistochemistry (ihc). positivity on staining of archival tumor tissue is adequate. * limited liver disease (less than 7 lesions with largest lesion less than 3 cm) * no surgical options with curative intent. * received prior therapy with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy in the advanced or metastatic setting, an anti-vascular endothelial growth factor (anti-vegf) biological therapy if not contraindicated, and if ras wild-type an anti-epidermal growth factor receptor (anti-egfr) therapy in a manner consistent with national comprehensive cancer network (nccn) guidelines. treatment must have been discontinued for disease progression or intolerance to therapy. * have at least one extracranial measurable target lesions according to the response evaluation criteria in solid tumors (recist) 1.1 standard. exclusion criteria: * subjects with tumor lesion(s) in a location that may cause perforation of an organ or structure (such as the digestive track, urinary bladder, or blood vessel) with gcc19cart therapy. * no active infectious diseases or comorbid conditions that would interfere with safety or data quality. * subjects with active infection requiring systemic therapy or causing fever (temperature \> 38.1˚c) or subjects with unexplained fever (temperature \> 38.1˚c) within 7 days prior to enrollment (leukapheresis) and reconfirmed prior to the day of investigational product administration. * pregnant or breast-feeding women other protocol defined inclusion/exclusion criteria may apply

Keywords: relapsed metastatic colorectal cancer refractory metastatic colorectal cancer chimeric antigen receptors (car) colorectal cancer
presurgical language mapping with fmri: comparison of bold and fasl techniques

Conditions: Brain Neoplasms

Summary: one of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk. the presurgical mapping of eloquent areas with functional magnetic resonance imaging (fmri) is helpful to plan the surgery. bold fmri is now the gold standard to map language areas. however, bold signal is diminished near the brain tumor. it is now possible to detect cortical activation with arterial spin labeling (asl) techniques, detecting variations of perfusion during an activation paradigm (fasl), fasl could be interesting to detect eloquent areas near a brain tumor.


Eligibility criteria:
inclusion criteria: * patient 18 years and older * brain tumor involving frontal and/or temporal lobe and/or insula, with scheduled neurosurgery * patient able of accepting protocol information * patient who received information about the protocol and had not expressed its opposition to participate exclusion criteria: * patient with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in mri * claustrophobic patient * patients who cannot cooperate for the fmri * patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Keywords: magnetic resonance imaging