Kornimate/medical-research-clean huggingface dataset:
a telehealth advance care planning intervention for older patients with acute myeloid leukemia and myelodysplastic syndrome

Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndromes

Summary: this is a pilot study to evaluate the usability and feasibility of a telehealth-delivered advance care planning intervention among 20 older patients with acute myeloid leukemia (aml) and myelodysplastic syndrome (mds).

older adults with aml and mds are more likely to receive aggressive care and less likely to utilize hospice at the end-of-life. advance care planning (acp) intervention delivered through telehealth may improve patient-reported outcomes and end-of-life care in this population. this pilot study seeks to evaluate the usability and feasibility of a telehealth-delivered advance care planning intervention. we will adapt the serious illness care program.

Eligibility criteria:
inclusion criteria for patients: * age ≥60 years (conventional definition of older age in aml/mds) * aml or mds diagnosis * being managed in the outpatient settings * able to provide informed consent * english-speaking exclusion criteria: n/a inclusion criteria for caregivers * age ≥21 years * selected by patient when asked if there is a "family member, partner, friend, or caregiver with whom you discuss or who can be helpful in health-related matters" * able to provide informed consent * english-speaking exclusion criteria: n/a

Keywords: acute myeloid leukemia myelodysplastic syndromes
encouraging mail order pharmacy use to improve outcomes and reduce disparities

Conditions: Diabetes Mellitus

Summary: the investigators propose a randomized encouragement trial to encourage use of the existing mail order pharmacy services among diabetes patients with poor adherence to cvd risk factor medications in 3 health care systems: kaiser permanente northern california, harvard pilgrim, and kaiser permanente hawaii.

adherence to effective cardiovascular disease (cvd) risk factor medications is associated with improved cvd risk factor control, fewer hospitalizations, and lower mortality in patients with diabetes. however, many patients are poorly adherent to medications, and there are persistent racial/ethnic and socioeconomic disparities in medication adherence. traditional clinical trials of interventions to improve medication adherence are often resource-intensive, and focus exclusively on patient-level barriers to behavior change. unsurprisingly, these trials have not led to sustainable, cost-effective approaches to improve adherence. health system-level medication adherence interventions that can be implemented, "scaled up," and sustained across a wide range of health care delivery settings are urgently needed. the investigators propose a randomized encouragement trial to encourage use of existing mail order pharmacy services among diabetes patients with poor adherence to cvd risk factor medications and who only use retail pharmacies in 3 health care systems: kaiser permanente northern california, harvard pilgrim, and kaiser permanente hawaii. these combined systems include approximately 300,000 patients with diabetes with diverse racial/ethnic and socioeconomic backgrounds. patients with no history of mail order pharmacy use will be randomized into 2 arms. in addition to examining the impact of the intervention on medication adherence and cvd risk factor control, the investigators will examine factors affecting the sustainability and dissemination of the intervention, assess the intervention's impact on utilization and health care costs, and determine whether the intervention's impact differs across racial/ethnic and socioeconomic subgroups. this research will provide a foundation for developing sustainable, system-level approaches to addressing medication adherence in diabetes patients that can be widely disseminated and implemented across a diverse array of health care systems.

Eligibility criteria:
inclusion criteria: * diabetes patients who are users of cvd risk factor medications (antihypertensive therapies, antihyperlipidemics therapies, and oral antihyperglycemic therapies), * diabetes patients considered to be poorly adherent to cvd risk factor medications within the prior 12 months * diabetes patients who have not used the mail order pharmacy to fill any prescribed medications at least once in the prior 12 months exclusion criteria: * pregnancy or dementia/traumatic brain injury diagnosis in the prior 12 months * hospitalized, in skilled nursing facility, hospice, or home health at the time of randomization.
self-management support for lung cancer patients with cachexia

Conditions: Cachexia-Anorexia Syndrome

Summary: the goal of this randomized clinical trial is to test the efficacy of self-management support based exercise combine nutrition intervention in lung cancer patient with cancer cachexia anorexia syndrome . the main question it aims to answer is: • would exercise combine nutrition intervention improve lung cancer patients' nutrition status? participants will make custom exercise plan and eat enough protein food after self-management support based education. and there is a comparison group: researchers will compare comparison group to see nutrition status who receive routine health education.


Eligibility criteria:
inclusion criteria: 1. diagnosed lung cancer(icd-10 code: c33-c34) 2. body weight loss: body weight loss 2% before recruitment 2 months or body weight loss 5% before recruitment 6months. 3. physician judged may do home exercise without supervisor. 4. has smart phone and agree to use exercise associated application. 5. agree to wear xioami smart band as long as passible. 6. conscious clear and communication. 7. eastern cooperative oncology group (ecog) 0-1. exclusion criteria: 1. participants with cardiovascular disease can't exercise without supervisor. 2. diabetes mellitus with blood sugar poor control. 3. chronic obstructive pulmonary disease with dyspnea on exertion. 4. platelets \< 50000mm3 due to disease or treatment. 5. hemoglobin \<10mg/dl. 6. recently stumble, severe pain, cognitive and behavior change. 7. suspect or diagnosed brain metastasis. 8. suspect or diagnosed bone metastasis. 9. receive nasogastric tube feeding or parenteral nutrition. 10. physician judged can't do home exercise.

Keywords: cancer cachexia syndrome exercise nutrition muscle endurance body mass index
a study of the association of sleep dysfunction and burning mouth syndrome

Conditions: Burning Mouth Syndrome

Summary: this is a case control study of the association between burning mouth syndrome and sleep dysfunction. cases will comprise of patients diagnosed with burning mouth syndrome at the ucsf oral medicine clinic. controls will include patients with leukoplakia, pigmented lesions, traumatic lesions, benign tumors, mucoceles, and pemphigoid matched on age (5 years) and gender to the cases. new patients as well as those presenting for follow-up visits will be eligible. each case and control subject will be administered the following 4 questionnaires by interview: (1) enrollment questionnaire (2) sleep scale from the medical outcomes study (mos), (3) current sleep status scale and (4) a numerical rating scale for measurement of oral symptoms. cases (bms patients) will be followed in the clinic or by telephone contact once per month for the following 6 months and questionnaires 1 (question 6 only), 2, 3 and 4 will be administered by interview.


Eligibility criteria:
inclusion criteria: * cases will comprise of patients diagnosed with burning mouth syndrome at the ucsf oral medicine clinic. * controls will include patients with leukoplakia, pigmented lesions, traumatic lesions, aphthous ulcers, reticular oral lichen planus, benign tumors, mucoceles, and pemphigoid matched on age (5 years) and gender to the cases. * new patients as well as those presenting for follow-up visits will be eligible. exclusion criteria: * age below 18 years * pregnancy * systemic corticosteroid therapy within the previous 2 weeks.

Keywords: burning mouth syndrome sleep neuropathic pain glossodynia chronic pain orofacial pain
effect of hemodialysis membranes on platelet count

Conditions: Thrombocytopenia

Summary: the purpose of this study is to determine if there is a drop in platelet count after hemodialysis. hemodialysis membranes are known to activate complement and cause a drop in platelets and sometimes in white blood cells. the investigators are going to study one of the membranes which is the fresenius optiflux® to check if it causes a drop in platelets.


Eligibility criteria:
inclusion criteria: * patients on hemodialysis for \>=6 months exclusion criteria: * hematological cancers * myelodysplastic syndromes * baseline thrombocytopenia * acute infections (patients on antibiotics) * patients with immune thrombocytopenic purpura (itp)/thrombotic thrombocytopenic purpura (ttp) * hiv * liver disease
soy nuts and cardiovascular risk in postmenopausal women

Conditions: Postmenopausal Women

Summary: to determine the effect of a whole soy food, dietary soy nuts, on blood pressure, lipid levels, inflammation and menopausal symptoms in postmenopausal women.

the present study examines the effect of a whole soy food, soy nuts (dry roasted soybeans), added to the therapeutic lifestyle change diet on blood pressure, lipids, inflammation and menopausal symptoms in postmenopausal hypertensive and normotensive women in a randomized crossover trial during an 8-week period. we sought to determine whether dietary soy had an additional benefit to the currently recommended heart healthy diet.

Eligibility criteria:
inclusion criteria: * women with absence of menses for at least 12 months or irregular periods and hot flashes. exclusion criteria: * were current cigarette smoking or smoking in the previous year; * clinical coronary artery disease, peripheral artery disease, or cerebrovascular disease; * known diabetes mellitus or a fasting glucose level of 126 mg/dl or greater; * a history of breast cancer; a fasting triglyceride level greater than 400 mg/dl; systolic bp of 165 mm hg or greater or diastolic bp of 100 mm hg or greater; * untreated hypothyroidism; systemic or endocrine disease known to affect lipid, mineral, or bone metabolism; * and consumption of more than 21 alcoholic drinks per week. * use of lipid-lowering drugs, hormone therapy, medications for osteoporosis, and soy products was discontinued for 2 months before entering the study. participants took a multivitamin but no additional vitamin or mineral supplements or other soy products during the study.

Keywords: isoflavones, hypertension, soy, diet, nutrition, women, inflammation, hot flashes
the relationship between ultrasonographic findings and sleep quality in carpal tunnel syndrome

Conditions: Musculoskeletal Diseases; Median Nerve Disease; Carpal Tunnel Syndrome; Ultrasound; Sleep Quality

Summary: the aim of our study is to determine the relationship between disease severity and sleep quality in cts patients and to compare the findings with healthy controls.

carpal tunnel syndrome is the most common form of entrapment neuropathies. anatomically, the roof of the carpal tunnel consists of carpal bones, it is located under the transverse carpal ligament, and there are 9 tendon packs of the forearm flexors and the median nerve. clinically, sensory (paresthesia and hypoesthesia), motor deficits and pain occur in the distribution of the median nerve secondary to mechanical compression and local ischemia. with the increase in the severity of the disease, entrapment neuropathy, whose symptoms are more pronounced at night, negatively affects the daily life of the person. waking up at night due to paresthesia is one of the diagnostic criteria for carpal tunnel syndrome. however, the mechanism linking cts with insomnia is unclear. the aim of our study is to determine the relationship between disease severity and sleep quality in cts patients.

Eligibility criteria:
inclusion criteria: * patients diagnosed with cts according to the criteria of the american academy of neurology exclusion criteria: * patients with radiculopathy, brachial plexopathy, thoracic outlet syndrome and traumatic nerve injury that may affect the median nerve * history of carpal tunnel surgery * pregnancy * malignancy * thyroid diseases * amyloidosis * systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, gout, dermatomyositis, polymyositis * obstructive sleep apnea

Keywords: carpal tunnel syndrome ultrasonographic evaluation pittsburgh sleep quality index
bortezomib with or without hormone therapy in treating patients with relapsed prostate cancer

Conditions: Prostate Cancer

Summary: rationale: bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. androgens can cause the growth of prostate cancer cells. drugs, such as goserelin, leuprolide, flutamide, or bicalutamide, may stop the adrenal glands from making androgens. giving bortezomib with hormone therapy may kill more tumor cells. purpose: this phase ii trial is studying how well giving bortezomib with or without hormone therapy works in treating patients with relapsed prostate cancer.


Eligibility criteria:
disease characteristics: * histologically confirmed adenocarcinoma of the prostate * relapsed disease after definitive local therapy, as documented only by a rise in prostate-specific antigen (psa) * experienced psa relapse after definitive local therapy * rising psa (≥ 1.0 ng/ml after nadir \< 1.0 ng/ml) * psa increase of ≥ 0.3 ng/ml (increase occurred between 2 separate measurements taken ≥ 4 weeks apart) * the first of these two psa values must rise above a previously recorded post-therapy nadir value * ineligible for curative therapy * no clinical evidence of local recurrence (i.e., palpable induration or mass in the prostatic fossa) other than psa elevation * no evidence of palpable disease in the prostatic bed * no metastatic disease (m0) * no non-nodal (\> n1) metastasis * no evidence of osseous metastasis on bone scan within the past 28 days patient characteristics: age * over 18 performance status * ecog 0-1 life expectancy * at least 1 year hematopoietic * platelet count ≥ 30,000/mm\^3 * absolute neutrophil count ≥ 1,000/mm\^3 hepatic * no known hepatitis b or c positivity renal * creatinine clearance ≥ 30 ml/min immunologic * no known human t-cell lymphotropic virus positivity * no hypersensitivity to bortezomib, boron, or mannitol * no known hiv 1 or 2 positivity * no active, ongoing bacterial, viral, or fungal infection other * fertile patients must use effective contraception * no peripheral neuropathy ≥ grade 2 * no other disease, condition, or social or geographic constraint that would preclude study participation * no other malignancy within the past 5 years except basal cell or squamous cell skin cancer prior concurrent therapy: biologic therapy * not specified chemotherapy * no concurrent chemotherapy endocrine therapy * see disease characteristics * at least 6 months since prior hormonal therapy combined with radiation therapy as definitive therapy * neoadjuvant hormonal therapy prior to definitive therapy (e.g., surgery, radiation therapy, brachytherapy, or cryoablation) allowed * no other concurrent hormonal therapy radiotherapy * see disease characteristics * more than 12 months since prior radioactive seed therapy * no concurrent radiotherapy surgery * see disease characteristics * more than 4 weeks since prior surgery * no concurrent surgery other * no concurrent second-line herbal preparations, including pc-spes * no other concurrent investigational agents

Keywords: adenocarcinoma of the prostate recurrent prostate cancer
equitable access to covid-19 vaccines

Conditions: Covid19

Summary: this study will deploy a multimodal pragmatic intervention to improve vaccine uptake in priority populations and address vaccine hesitancy to improve access by using a proactive organized population-based outreach leveraging health information technology with tailored navigation support to address mistrust and social barriers.

this study will deploy a multimodal pragmatic intervention to improve vaccine uptake in priority populations through a proactive organized population-based outreach approach. it will leverage health information technology with tailored navigation support to address mistrust and social barriers. study key objectives are to: 1. conduct a survey of patients to assess and track barriers, intent, and sources of information on covid vaccine over time. 2. determine whether a primary care physician (pcp) endorsement with or without interactive digital communication plus navigation is more effective in promoting uptake of covid-19 vaccine than general messages from the clinic. patients will be randomized to one of three arms: 1. arm 1: message about vaccine availability delivered by sms advising patients to make an appointment. 2. arm 2: same as arm 1 but delivered as a personalized message text from the pcp. 3. arm 3: same as arm 2 plus a interactive 2-way sms options.

Eligibility criteria:
inclusion criteria: 18 years and older, receiving care at adelante healthcare and not vaccinated or already scheduled for vaccination through the health center's appointment system exclusion criteria: patient younger than 18 or who have been previously or are selected for vaccination during or prior to the week of study enrollment
remote fu's subcutaneous needling for patients with chronic neck pain

Conditions: Chronic Neck Pain; Sleep Quality

Summary: this is a randomized controlled trial to compare the efficacy of fu's subcutaneous needle (fsn) and transcutaneous electrical nerve stimulation (tens) on chronic neck pain by using more objective assessment tools such as neck disability index, visual analog scales, pressure pain threshold and myotone of mtrps of upper trapezius muscles, range of motion of stretch of upper trapezius muscle, and pittsburgh sleep quality index.

neck pain combining limited range of motion is very common. lasting for only a few days, it will taper off without any treatment. if the neck pain symptoms persist for more than two months without any improvement, it will be categorized as chronic neck pain causing not only pain but also functional impact, even in daily life, working, and sleep quality. fu's subcutaneous needling is utilized in treating disease related with myofascial trigger point, including soft tissue pain, joint pain, even some internal problems. indeed it reduce pain immediately with no obvious side effects. there were some clinical articles of subjective symptoms description published lacking scientific accessment of efficacy. research team leading by professor chang-zern hong has already prove that excitability can be reduced by distal acupuncture. needling te5 and li11 can reduce pain intensity and average amplitude of mtrps end plate in upper trapezium m., and increase pain pressure threshold. comparing to traditional acupuncture, whether safer and pain-less fu's subcutaneous needle also has the distal treatment effect or not still needs more scientific experiment to prove. this is a randomized controlled trial to compare the efficacy of transcutaneous electrical nerve stimulation and fu's subcutaneous needle on chronic neck pain by using more objective assessment tools such as neck disability index, visual analog scales, pressure pain threshold and myotone of mtrps of upper trapezius muscles, range of motion of stretch of upper trapezius muscle, and pittsburgh sleep quality index.

Eligibility criteria:
inclusion criteria: * having chronic neck pain for more than 2 months and subjective subjective pain intensity (vas) greater than 5 points. * patients with myofascial pain diagnosed with unilateral upper trapezius muscle. * this pain is not effective for previous medication or physical therapy. exclusion criteria: * contraindications for general treatment, such as serious medical problems, recent trauma, or pregnancy. * there has been a history of drug abuse (including excess alcohol) that affects pain assessors. * have received neck, upper back, or upper and lower limb surgery. * people with central or peripheral nerve disease. * cognitive dysfunction cannot be matched with the experimenter. * people with cardiac pacemakers, epilepsy, etc. cannot place electrode patches on the skin.

Keywords: fu's subcutaneous needle transcutaneous electrical nerve stimulation
data analysis for drug repurposing for effective alzheimer's medicines (dream) - tofacitinib vs abatacept

Conditions: Rheumatoid Arthritis

Summary: this study aims to evaluate the comparative risk of dementia/alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.

this is a non-randomized, non-interventional study that is part of the dream study of brigham and women's hospital. dream is led by dr. madhav thambisetty, md, phd, chief of the clinical and translational neuroscience section, laboratory of behavioral neuroscience, national institute on aging (nia) intramural research program. this study aims to evaluate the comparative risk of dementia/alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication using healthcare claims data.

Eligibility criteria:
please see https://docs.google.com/spreadsheets/d/1kucnitjl1ppb9xkydvboqskx5dnrz6nexhkw6p5unly/edit?usp=sharing or appendix a for full code and algorithm definitions. medicare timeframe: 2007 to 2017 (end of data availability). inclusion criteria: * 1. no prior use of tofacitinib or abatacept anytime prior to cohort entry date * 2. enrollment in medicare part a, b, and d with no hmo coverage for 365 days prior to and including cohort entry date exclusion criteria: * 1. prior history of dementia measured anytime prior to cohort entry date * 2. no prior history of rheumatoid arthritis recorded in the 365 days prior to cohort entry date * 3. prior history of nursing home admission in the 365 days prior to the cohort entry date
fmri investigation of depression in patients with epilepsy

Conditions: Epilepsy; Depression

Summary: depression is very common in epilepsy. depression is the strongest predictor of poor quality of life in patients with epilepsy. the biological basis for depression in epilepsy remains poorly understood. this study uses functional mri (fmri) to examine brain response to emotional and non-emotional stimuli in healthy control subjects and in patients with epilepsy who are either depressed or not depressed. results from this study will contribute to a better understanding of depression in epilepsy, which may eventually inform development of better treatment modalities..


Eligibility criteria:

Keywords: epilepsy depression fmri emotion
efficacy and safety of sunitinib in women with advanced breast cancer

Conditions: Breast Neoplasms

Summary: patients with advanced breast cancer to receive sunitinib (sutent) once daily until disease progression.


Eligibility criteria:
inclusion criteria: * histologically or cytologically proven diagnosis of breast cancer * metastatic or locally recurrent disease that is, in the opinion of the investigator, not amenable to resection or radiation therapy * patients with at least one measurable lesion as per recist exclusion criteria: * inflammatory breast cancer * prior treatment with vegf inhibitors (unless in adjuvant setting at least 12 months ago)

Keywords: metastatic breast cancer