Kornimate/medical-research-clean huggingface dataset:
comparison of efficacy between a newly designed covered stent and uncovered stent for malignant colorectal obstruction

Conditions: Colorectal Cancer

Summary: acute colorectal obstruction has been reported to occur in 7 - 29% of all colorectal malignancies, but emergent surgical decompression is associated with high morbidity and mortality rates. recently, self-expandable metal stents(sems) have been suggested as an alternative to surgery and effectively decompress the colonic obstruction and allow for bowel preparation and elective surgery. theoretically, semss are classified into uncovered stents and covered stents. covered stents have the advantage of less frequent stent occlusion by tumor in-growth and the disadvantage of a high risk of stent migration, whereas uncovered stents are associated with less stent migration, although they appear to be more prone to tumor ingrowth. to overcome the drawbacks of conventional stents, a double-layered combination covered stent was developed. in the present study, the investigators evaluated the efficacy and safety of the newly designed covered stent by comparing it with the uncovered stent in patients with malignant colorectal obstruction.


Eligibility criteria:
inclusion criteria: * 20\~85-year-old patients with malignant colorectal obstruction either by primary crc or extracolonic malignancy * patients with clinical obstructive symptoms confirmed by ct or colonoscopy exclusion criteria: * patients with evidence of bowel perforation or peritonitis * cause of obstruction other than malignancy (bowel adhesion or benign stricture) * multiple stricture * lower rectal cancer obstruction (av \<5cm)
rtms in wilson disease dysarthria

Conditions: Wilson Disease

Summary: wilson disease is a hereditary hepatic and neurological disease associated with copper accumulation. neurological symptoms are of extra-pyramidal, cerebellar and dystonic origin. dysarthria is one of the debilitating symptoms of wilson disease poorly responsive to pharmacological treatment. the most common form is a dystonic hyperkinetic dysarthria. pathophysiology of dystonia is still not elucidated. motor cortex hyperexcitability has been demonstrated in various forms of dystonia. furthermore, rtms inhibitory applied over motor cortex has been shown to transitory reduce dystonic symptoms in various forms of dystonia. in the present study, we investigate the effect of a single 1hz 20-minutes inhibitory rtms session applied over the motor laryngeal cortex on dyasarthria is the main kinetic dysarthria has been shown to be associated with inhibition of laryngeal motor cortex in parkinson disease.

a consecutive series of wilson disease patients with dystonic hyperkinetic dysarthria will be prospectively recruited. patients will receive 3 days apart to two rtms sessions. rtms procedures will be performed with a figure of eight coiled. a single 20-minutes 1 hz biphasic stimulation (1200 pulses) session will be applied over the laryngeal motor cortex. a brain imaging positioning device will be used during all the procedure a second stimulation session will be performed 3 days apart. patients will be centrally randomized to receive first either the active stimulation (80% of the resting motor threshold) or the sham stimulation (using a visually identical coil to reproduce the click sound and the scalp sensation of the active coil). a tms evaluation of cortical silent period over the left motor cortex will be performed before the first rtms session. before and immediately after each stimulation (active or sham) patient will received an clinical evaluation including clinical assessment battery for dysarthria intelligibility score, "a" phonation time, diadococinesia , bucco-linguo-facial motricity score and uwdrs. a standard 20-minutes eeg will be performed before the first rtms session and immediately after the second rtms session.

Eligibility criteria:
inclusion criteria: * conseting adult patients with social insurance * wilson disease with dystonic hyperkinetic dysarthria * stable pharmacological therapy n the last 6 monts * brain mri in the previous 6 months, without additional brain lesion * patients that did not receive botulinium toxin in the previous 4 months exclusion criteria: * incapacitated adult * previous mdedical history of epilepsia * pregnancy or breastfeeding * brain lesion outside basal ganglia on brain mri * patient consider by the investigator not able to sustain an 30 minutes rtms session without moving * vocal chord lesion * previous history of laryngeal surgery * rtms contra indication

Keywords: dyasarthria, repetitive transcranial magnetic stimulation
noninvasive hemoglobin testing, prospective blood donors

Conditions: Healthy; Anemia

Summary: the objective of this clinical investigation is to evaluate the pulse oximeter devices for screening prospective blood donors. the purpose study is to report on the accuracy of noninvasive hemoglobin (sphb) as compared to hemoglobin measurements obtained from a laboratory hematology analyzer in a blood donation setting.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * weight at least 110 pounds * subjects with the intention of being screened for eligibility to donate blood * the subject has given written informed consent to participate in the study exclusion criteria: * subjects with skin abnormalities at the planned application sites that may interfere with sensor application, per directions-for-use (dfu) or trans-illumination of the site, such as burns, scar tissue, infections, abnormalities, etc. * subjects unwilling and/or unable to remove nail polish or acrylic nails * subjects with blood cancers such as leukemia * subjects with hemoglobin disorders such as sickle-cell anemia and thalassemia * subjects with known history of infectious diseases such as hiv/aids, syphilis, hepatitis, etc. * subjects with self-disclosed/known pregnancy at the time of enrollment * subjects deemed not suitable for the study at the discretion of the investigator * excessive motion includes postural changes, making hand gestures, involuntary muscular movements, etc.
effects of fish oil on platelet function and coagulation

Conditions: Platelet Aggregation, Spontaneous; Atherosclerosis; Surgery

Summary: many patients undergoing surgery use naturopathic drugs, including fish oil. fish oil has been reported to increase bleeding in patients through inhibiting platelet aggregation and prolonging of clot formation time. the swedish medical products agency recommends that patients stop taking the naturopathic medicines including fish oil two weeks prior planed surgery. the aim of this study is to examine the effects of fish oil given to healthy volunteers using point of care coagulation assessment and flow dependent cellix instrument before and after intake of fish oil.

healthy volunteers will be given maximum dose of fish oil for 7 days. blood samples will be collected before and immediately after the 7 days of intake and analysed using point of care coagulation assessment instruments and flow dependent platelet aggregation using a microfluid flow controlled system (cellix). for point of care coagulation assessment the multiple electrode platelet aggregometer multiplate, the viscoelastic rotational thromboelastometers rotem and sonoclot will be used. flow cytometry may also be utilized.

Eligibility criteria:
inclusion criteria: * non smoking healthy volunteers with written consent to participate exclusion criteria: * medication affecting coagulation or platelets within 14 days priori to inclusion

Keywords: thrombocyte aggregation fish oil alternative medicine point of care testing coagulation monitoring
the effectiveness of postural stabilization exercises in patients with chronic neck pain

Conditions: Neck Pain

Summary: this study aimed to evaluate the effect of postural stabilization exercises given in addition to cervical stabilization on craniovertebral angle, neck disability index, and quality of life in people with chronic neck pain.sixty women with chronic neck pain between the ages of 20-60 were included in the study and the individuals were randomly divided into two groups. individuals in the first group underwent cervical stabilization (cs) exercises and additional scapular and lumbopelvic stabilization (slps) exercises three times a week for 6 weeks. the second group was treated with only cs exercises for the same period. in addition, stretching exercises and a 20-minute hot pack were applied to the muscles around the neck of all patients. craniovertebral angle (cva) was measured by photogrammetry. disability level was measured by the neck disability index (ndi). the turkish version of the short form-36 (sf-36) was used to assess quality of life.


Eligibility criteria:
inclusion criteria: * the study included females between the ages of 20-60 years, with moderate pain intensity (3 cm and above according to the visual pain scale) and neck pain lasting more than 3 months. exclusion criteria: * participants who had undergone any shoulder or neck surgery complained of fibromyalgia and myofascial pain syndrome, had a neurological disease, cervical radiculopathy, and serious systemic disease that would interfere with treatment, and who were pregnant were excluded from the study
concurrent vestibular activation and postural training using virtual reality

Conditions: Vestibular Disorder

Summary: postural instability is a common symptom of vestibular dysfunction that impacts a person's day-to-day activities. vestibular rehabilitation is effective in decreasing dizziness, visual symptoms and improving postural control through several mechanisms including sensory reweighting. as part of the sensory reweighting mechanisms, vestibular activation training with headshake activities influence vestibular reflexes. however, combining challenging vestibular and postural tasks to facilitate more effective rehabilitation outcomes is under-utilized. the novel concurrent headshake and weight shift training (concurrent hs-wst) is purported to train the vestibular system to directly impact the postural control system simultaneously and engage sensory reweighting to improve balance. healthy older adults will perform the training by donning a virtual reality headset and standing on the floor or foam pad with an overhead harness on and a spotter present to prevent any falls. the investigators propose that this training strategy would show improved outcomes over traditional training methods by improving vestibular-ocular reflex (vor) gains, eye movement variability, sensory reweighting and promoting postural balance. the findings of this study may guide clinicians to develop rehabilitation methods for vestibular postural control in neurological populations with vestibular and/or sensorimotor control impairment.


Eligibility criteria:
inclusion criteria: * able to stand independently (without an assistive device) * this study requires participants to perform postural assessments including reactive balance following mechanical perturbations. * participants will also perform headshake activities and weight shift training in standing for 20 mins will mini breaks. * participants must be between the ages of 55-80. exclusion criteria: * participants with evidence of: * concussion, vestibular, balance or oculomotor issues for the prior 6 months. * neuropathic conditions, particularly affecting the lower extremities. participants with this issue will have sensory impairments which can affect their sensory assessment. * current musculoskeletal deficits including significant postural abnormalities (signs of spinal, pelvic and leg length discrepancies). * pain or limitations in neck range of motion. * recent (within 6 months) orthopedic surgery that impacts postural training. * visual impairment ○ participants must be able to see and follow targets in the virtual reality environment. therefore, subjects must have 20/50 (corrected) vision. subjects who are blind cannot participate.

Keywords: sensory reweighting vestibular rehabilitation vestibular reflex virtual reality
oral diindolylmethane (dim) for the treatment of cervical dysplasia

Conditions: Cervical Dysplasia

Summary: to determine if the use of oral diindolylmethante (dim), a marketed cruciferous vegetable based dietary supplement (bioresponse-dim), is associated with the regression of cervical dysplasia in otherwise healthy women.

to determine if the use of oral diindolylmethane (dim), a marketed cruciferous vegetable based dietary supplement (bioresponse-dim®), is associated with the regression of cervical dysplasia in otherwise healthy women. additionally, the study aims to see how the use of the bioresponse-dim supplement correlates with cervical hpv colonization, and to asses the tolerability of daily dim supplementation

Eligibility criteria:
inclusion criteria: * non pregnant women greater than or equal to 18 years of age able to consent * cin ii or iii confirmed by histology * karnofsky performance status \>= 80 * no prior treatment for dysplasia in the past 4 months exclusion criteria: * incompletely visible lesion * diethylstilbestrol (des) exposure * hiv seropositive

Keywords: cervical dysplasia, diindolylmethane, pap smear
intubation and extubation over 48 hours mechanical ventilation

Conditions: Pneumonia, Ventilator-Associated; Critical Illness

Summary: the purpose of this study is to determine how often ventilator associated pneumonia happens in the current intensive care units, and how types of endotracheal tube affect its occurrence.


Eligibility criteria:
inclusion criteria: * age \> 20 years old * mechanically ventilated over 48 hours in the icu exclusion criteria: * mask ventilation * tracheostomy

Keywords: respiration, artificial pneumonia, ventilator-associated critical illness
quality control of ce-certified phonak hearing aids - 2019_34

Conditions: Hearing Loss

Summary: phonak hearing devices pass through different development and study phases. at an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner. if the benefit is proven, their performance is then investigated regarding interdependency between all available algorithms, features and functions running in parallel in a hearing aid (pivotal/pre-validation studies) and, resulting from the pre-validation studies, they get optimized. prior to product launch, the phonak hearing systems get reviewed by a final quality control in terms of clinical trials. this is a validation study, investigating improved algorithms, features, functions and wearing comfort. this will be a clinical investigation which will be conducted mono centric at sonova ag headquarters based in stäfa (switzerland).

this study will compare two settings of an external microphone under real life conditions with experienced hearing aid users. the external microphone streams the signal (e.g. speaker) directly into the hearing instrument (hi). the subject should rate the devices in the lab and after a hometrial. the comfort, regarding to the loudness and the sound quality will be tested with the two settings at home and in the lab. also the speech intelligibility will be tested in the lab. this will be a clinical investigation which will be conducted mono centric at sonova ag headquarters based in stäfa (switzerland).

Eligibility criteria:
inclusion criteria: * experienced hearing aid user * severe hearing loss * willingness and interest in testing an external microphone healthy outer ear * willingness to wear behind the ear hearing aids * informed consent as documented by signature exclusion criteria: * the audiogram is not in the fitting range of the intended hearing aid * limited mobility and not in the position to attend weekly appointments in stäfa (switzerland) * participant is not able to describe experiences and hearing impressions
strengthening in sub-acute stroke survivors: a randomized controlled trial

Conditions: Hemiparesis;Poststroke/CVA

Summary: the goal of this study is to compare between eccentric training and conventional therapy in sub-acute stroke survivors. the primary objective of this study is to evaluate improvements in gait speed after four months of et in comparison to conventional therapy for patients with sub-acute stroke. secondary objectives involve assessing: i) modifications in neuromuscular parameters of pf, ii) changes in muscle stiffness within pf during passive mobilization and active force generation, and iii) modifications in architectural parameters of pf.

this study will be a single-blinded, controlled, randomized design, wherein participants will be randomly assigned to one of two groups: the conventional therapy group (ctg) or the eccentric training group (etg). both groups will undergo a comprehensive series of assessments at three key time points: ji (initial assessment), jint (intermediate assessment), and jf (final assessment). the study will commence with a recruitment phase, followed by a screening phase. subsequently, there will be a 4-week period allocated for experimental testing before the intervention, and an additional 4 weeks for experimental testing after the intervention. these assessments will encompass a wide range of evaluations, including clinical health assessments, biomechanical assessments, neuromuscular evaluations, and functional assessments

Eligibility criteria:
inclusion criteria: * subacute hemiparesis (\> 3 months) * bmi between 18.5 and 25 * written consent to participate in the study. exclusion criteria: * ankle impairment * botulinum toxin injections in pf within the last 4 months before study inclusion * medical contraindication for maximal effort * neurodegenerative disorders * cardiovascular disorders * history of epilepsy.

Keywords: rehabilitation skeletal muscle eccentric strengthening
an exploratory clinical study of shr6390 and shr1020 in the treatment of esophageal squamous cell carcinoma after progression on pd-1 antibody

Conditions: Esophageal Squamous Cell Carcinoma; Progression to PD-1 Antibody

Summary: this study is being conducted to explore the efficacy of shr-6390 and shr-1020 in the treatment of esophageal squamous cell carcinoma after progression on pd-1 antibody.


Eligibility criteria:
inclusion criteria: * patients who were diagnosed as esophageal squamous cell carcinoma by histopathology with at least one measurable lesion according to recist 1.1 criteria. * must have had progressive disease after previous treatment with pd-1 inhibitor * ecog score 0-2 * the expected survival time is ≥ 12 weeks * previous permanent discontinuation did not occur due to adverse events associated with immunotherapy, or the immunotreatment-related adverse events recovered to ≤1 grade exclusion criteria: * had other active malignant tumors within 5 years before entering the study * had abnormal swallowing function or dysfunction of gastrointestinal absorption * the first study drug treatment was less than 28 days or 5 half-lives (in terms of longer) from the last radiotherapy, chemotherapy, targeted therapy or immunotherapy * patients who have already received surgery within 28 days (biopsy for diagnosis is permitted) * pregnant or lactating women
effect of virtual reality (vr) on pain relieve during colonoscopy

Conditions: Pain; Colonoscopy

Summary: purpose: to evaluate the effectiveness and safety of virtual reality (vr) technology in alleviating pain during colonoscopy. design and methods: in the context of a single-centered, prospective, randomized controlled study, the pain levels experienced during colonoscopy are compared between the vr group and the control group.

patient allocation to either the vr group or the control group will be determined through a randomization process employing sealed opaque envelopes. patients in the vr group will engage in interactive gaming experiences facilitated by vr devices. the primary outcome measure will be the assessment of pain levels during colonoscopy, which will be quantified using the "visual analogue scale." additionally, researchers will assess anxiety levels using the "state-trait anxiety inventory" both before and after the colonoscopy procedure. vital signs during colonoscopy, procedural effects, and adverse effects would also be analyzed.

Eligibility criteria:
inclusion criteria: * between 18 and 50 years of age * able to cooperate and complete the questionnaires independently * stable vital signs with no serious cardiovascular or cerebrovascular diseases * voluntary participation exclusion criteria: * severely impaired in vision or hearing to accommodate vr devices * previous history of anxiety, depression, cognitive impairment, balance disorder, mental illness, or epilepsy
comparison of erector spinae plane block and intravenous patient-controlled analgesia in percutaneous nephrolithotomy

Conditions: Nephrolithiasis; Percutaneous; Analgesia; PCA

Summary: the primary purpose of this study was to compare the effects of erector spinal plane block (esp) and iv patient-controlled analgesia (pca) performed to provide analgesia in percutaneous nephrolithotomy surgeries on visual analog skala (vas), additional analgesia need, patient satisfaction and mobilization times.

asa i-iii patients aged 18-65 years who underwent percutaneous nephrolithotomy at van yüzüncü yıl university faculty of medicine were included in the study. the patients were informed about the study during the preoperative evaluation. in the randomized single-blind closed-envelope study, 30 patients ineach group and a total of 60 patients were included. standard general anesthesia procedure was applied to all patients. standard general anesthesia procedure was applied to all patients. perioperative hemodynamic monitoring was performed. in patients who underwent general anesthesia, after the surgical procedure was completed, after sterility was ensured for the esp group while the patient was in the lateral position for the espb procedure, the linear 10-18 mhz usg probe (esaote mylab 30, geneva, italy) was placed between two transverse processes in the paramedian plane and increased from 1mg/kg to %1 at the t7 level. 20 ml of 0.5 bupivacaine (buvasin®, vem, istanbul, turkey) + 2% arrhythmic residual sf from 1mg/kg was administered. for patients in the pca group, 200 mg of tramadol was placed in 100cc of 0.9% nacl. set to pca device. a 50mg loading dose was administered 10 minutes before the patient was extubated. after extubating, a bolus dose of 20 mg was started, with a 30-minute lock-in time, and an infusion dose of 5mg/hour. the 4-hour maximum limit was set to 200 mg. vas score, need for additional analgesia, patient satisfaction (likert scale), mobilization times and vital signs were recorded at 30 minutes, p1, 3, 6 and 12 hours after the operation.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) class i-iii, * between 18-65 years old, * percutaneous nephrolithotomy surgery, * patients who agreed to participate in the study exclusion criteria: * obesity (bmi≥ 35) * coagulopathy * active infection * drug allergies * pregnancy * 65 years and older

Keywords: percutaneous nephrolithotomy plane block patient-controlled analgesia