Kornimate/medical-research-clean huggingface dataset:
sleep architecture & cognition in focal epilepsy

Conditions: Focal Epilepsy

Summary: focal epilepsy (fe) patients and healthy controls will wear an actigraph at home for one week and a home sleep study device at home for one night. participants will then undergo two nights of testing (at least one week apart) at california sleep solutions (css) in sacramento, ca. during the overnight stays, participants will have eeg leads placed and possibly a headband. they will undergo cognitive testing before they go to sleep and again in the morning. during one night of testing, sounds will be played in the room (acoustic stimulation). the sounds should not wake the participants.

this study will investigate the interconnections between sleep physiology and cognitive deficits in fe and will provide essential pilot data for an interventional trial to characterize the comprehensive effects of as/es on sleep and cognition in fe. the long-term goal of this project is to leverage the connections between sleep, behavior, and neural network activity to develop and implement tailored cognitive and sleep interventions for individuals with epilepsy. aim 1: characterize sleep architecture patterns in focal epilepsy (fe) and determine the relationship to cognitive processing. aim 2: determine the effect of sleep stimulation (acoustic and/or electrical - as/es) on sleep architecture patterns and cognitive processing in fe. aim 1 hypothesis: compared to controls, fe patients will exhibit interictal epileptiform discharges (ieds) as well as reduced sleep spindle density and slow wave power with reduced slow wave sleep spindle oscillations (sw-sso) coupling. aim 1 hypothesis: compared to controls, reduced sw-sso coupling during sleep in fe patients will be associated with poorer memory and attention. aim 2 hypothesis: as/es will exhibit greater levels of sw-sso coupling compared to sham stimulation. aim 2 hypothesis: compared to sham, as will show increased connectivity on eeg, and improved memory and attention.

Eligibility criteria:
inclusion criteria: * age 18 - 40 years of age * focal epilepsy * capacity to fully cooperate and follow directions * no other significant neurological disorders which could affect cognition exclusion criteria: * current use of any medications that can significantly affect cognition * no severe sleep apnea

Keywords: epilepsy
percutaneous recanalization in ischemic stroke management (priism): a feasibility clinical study

Conditions: Ischemic Stroke

Summary: the primary study objective is to assess the feasibility of using the mindframe system to safely and effectively restore blood flow in a thrombotic neurovascular occlusion in patients experiencing an ischemic stroke.

the objective of priism is to assess the feasibility of using the mindframe system to safely and effectively restore blood flow in a thrombotic neurovascular occlusion in patients with acute ischemic stroke. safety will be assessed by the device-related serious event rate as it compares to other similar therapies. the events include but are not limited to symptomatic hemorrhage, vessel dissection, embolization and overall morbidity and mortality. target vessels include the basilar, internal carotid and middle cerebral (m1 and m2 segments) arteries.

Eligibility criteria:
inclusion criteria: 1. nihss 6 to 30 within 6 hours of symptom onset 2. pre-stroke modified rankin score ≤ 2 3. large vessel occlusion 4. patient/patient guardian is willing to comply with the protocol requirements and return to the treatment center for all required clinical evaluation. 5. patients must meet at least one of the following criteria: * eligible for intravenous rt-pa * eligible for intra-arterial rt-pa - ia rt-pa initiated within 6 hours of symptom onset * patient presents within 6 hours of symptom onset exclusion criteria: 1. pregnancy 2. glucose \<50mg/dl 3. known hemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with inr\>3.0 4. patient received heparin within 48 hours with a ptt greater than 2 times the lab normal. 5. patient has baseline platelets \< 30,000 6. evidence of rapidly improving neurological signs of stroke at time of enrollment 7. coma 8. pre-existing neurological or psychiatric disease that could confound the study results 9. known severe allergy to contrast media or nitinol 10. patient has severe sustained hypertension 11. ct/mri scan reveals significant mass effect with midline shift 12. patient's angiogram shows an arterial stenosis \>50% proximal to the embolus. 13. patient's anticipated life expectancy is less than 3 months 14. participation in another clinical investigation that could confound the evaluation of the study device

Keywords: cerebral infarction stroke vascular diseases central nervous system diseases penumbra functional outcome aphasia hemiplegia left sided weakness right sided weakness
safety and effectiveness of aquamid as compared to restylane for the aesthetic treatment of nasolabial folds

Conditions: Facial Wrinkles

Summary: the purpose of this study is to compare the effectiveness of aquamid and restylane in aesthetically enhancing nasolabial folds 6 months after treatment and to evaluate the safety of aquamid through 12 months after treatment. the study includes an extended follow up to 24 months.


Eligibility criteria:
inclusion criteria: * interested on soft tissue augmentation for the nasolabial folds * moderate to severe nasolabial fold exclusion criteria: * sensitivity to anesthetics * allergy to hyaluronic acid * previous treatment with permanent fillers in the treated area * recent previous aesthetic procedure in the treatment area * infected skin areas or autoimmune diseases affecting the skin

Keywords: wrinkles soft tissue filler aquamid
transmural care for chronically ill children: scientific guidance and evaluation of pilot projects

Conditions: Chronic Diseases in Children; Chronic Diseases in Adolescence; Health Personnel; Parents

Summary: the goal of this realist evaluation is to evaluate the implementation of pilot projects for transmural care in chronically ill children. the main question it aims to answer is: to what extent and how do the pilot projects for transmural care for chronically ill children provide an answer to the quintuple aim? participants will * complete questionnaires at three timepoints * participate in focus group interviews

introduction chronic diseases have been increasing over the past few years, including in children. the chronic condition affects their daily functioning and quality of life and leads to frequent hospital admissions. to avoid unneccessary hospital admissions and to offer alternative and innovative forms of care, the belgian federal public service of public health, food chain safety and environment selected five pilot projects for transmural care for chronically ill children. this study was designed to evaluate these projects. methods and design the overall approach is a two-year longitudinal prospective realist evaluation using a mixed-methods design. the quantitative strand, using routine data and questionnaires, will examine whether data from children, parents/legal guardians and healthcare professionals involved in a pilot project for paediatric transmural care comply with the quintuple aim outcomes. the qualitative strand will be used (1) to evaluate the structure of the interventions, (2) for process evaluation and context analysis, and (3) to gather more in-depth information. this includes document analysis (including logbooks), focus groups with children, parents/legal guardians and healthcare professionals, and non-participatory observations. ethical informed consent is required prior to inclusion in the evaluation study. informed assent is requested from children older than 12 years. for this study, advice is asked from the research ethics committee of ghent university hospital

Eligibility criteria:
inclusion criteria: * children: any child up to the age of 18 participating in a pilot project for paediatric transmural care. * parent/legal guardian: any parent or legal guardian of a child participating in a pilot project for paediatric transmural care * healthcare professionals: any healthcare professional with patient contact involved within a pilot project for paediatric transmural care * coordinators: all study and care coordinators involved within a pilot project for paediatric transmural care exclusion criteria: * no signed informed consent form available

Keywords: realist evaluation chronic disease child adolescent infant home care services, hospital-based
accelerated fractionation radiotherapy (afrt) versus concurrent chemoradiotherapy (crt) in locally advanced head and neck squamous cell carcinoma

Conditions: HEAD AND NECK CANCER

Summary: the aim of this trial is to compare the accelerated fractionation radiotherapy and concurrent chemo-radiotherapy in locally advanced head and neck squamous cell carcinoma patients in terms of loco-regional control, toxicities and quality of life.

concurrent chemo-radiotherapy is a common and conventional method of treating locally advanced head and neck squamous cell carcinoma (hnscc). in locally advanced hnscc it has been proved to be superior to radiotherapy alone. on the other side accelerated fractionation radiotherapy (afrt) is a proven practice to improve cure rate in head and neck cancers. yet it has not been compared with concurrent chemoradiotherapy (crt) in locally advanced hnscc and hence this study is aiming to compare crt versus afrt.

Eligibility criteria:
inclusion criteria: 1. age: 20 - 60 years old 2. karnofsky performance scale score 70 or above 3. biopsy proven squamous cell carcinomas (scc) of oropharynx, larynx and hypopharynx 4. tnm stages- stage iii -ivb 5. informed consent (in prescribed form under institutional guidelines) exclusion criteria: 1. lack of histopathological proof of malignancy (hnscc) 2. doubtful follow-up and/ or non-compliance 3. previous oncologic therapy with surgery, radiotherapy or chemotherapy 4. uncontrolled comorbid conditions e.g hypertension, diabetes mellitus, chronic obstructive pulmonary disease, coronary artery disease
efficacy and safety of microwave ablation in bosniakⅰ~ⅱf cystic renal lesions

Conditions: Kidney Diseases,Cystic

Summary: the purpose of this study is to determine whether microwave ablation is more effective in the treatment of simple renal cysts than conventional laparoscopic decortication.

background: simple renal cysts are the most common renal masses, and occur in half of all patients older than 50 years.they are usually asymptomatic and benign, asymptomatic and discovered incidentally. however, over time, these simple cysts can enlarge, become symptomatic and develop complications, requiring intervention.they can be managed by a variety of surgical and percutaneous methods, including percutaneous aspiration (with or without injection of a sclerosing agent), endoscopic marsupialization or excision, open surgery and laparoscopic cyst excision.percutaneous aspiration and sclerotherapy have been described as safe and effective methods of managing symptomatic simple renal cysts without the cost and morbidity associated with conventional surgery and laparoscopy.however, laparoscopic decortications and simple aspiration is associated with a high recurrence rate because the cyst wall epithelium is responsible for active liquid production. purpose:to determine whether microwave ablation is more effective in the treatment of simple renal cysts than conventional laparoscopic decortication. method:

Eligibility criteria:
inclusion criteria: * patients with sporadic, unilateral, newly diagnosed bosniak ⅰ, ⅱ and ⅱf renal cyst * patients agreeable to participate in this long-term follow-up study * patients with normal contralateral renal function (differential renal function of \>40% as determined by radionuclide scintigraphy) exclusion criteria: * patients' aged \>80 years * patients not able to tolerate the microwave ablation procedure * patients with previous renal surgery or history of any inflammatory conditions of the operative kidney * patients with the renal cyst involving urinary collecting system * patients with other renal diseases,(including kidney stone, glomerular nephritis, etc.) which might affect the renal function of the operative kidney

Keywords: laparoscopy microwave ablation technique
respiratory functions, trunk control and mobility evaluation in multiple sclerosis

Conditions: Physical Therapy

Summary: respiratory functions and body control are affected in patients with multiple sclerosis (ms). because of this effect, the dependency of individuals increases in daily living activities and their quality of life decreases. we think that respiratory functions, respiratory muscle strength and trunk control affect vital mobility as well as vital importance for individuals with ms. as a result of the investigations, it is concluded that the literature is insufficient in this area. the aim of this study is to investigate the effects of pulmonary function, respiratory muscle strength and trunk control on functional mobility in individuals with ms and compare with healthy individuals.


Eligibility criteria:
inclusion criteria: * 18-65 years old * having a definite ms diagnosis * up to 5.5 points on the scored disability status scale (edss) * in the last 3 months have not experienced an attack * mini mental test score of 24 and above * acceptance to participate in the study. exclusion criteria: * having orthopedic problems * the presence of other neurological problems

Keywords: multiple sclerosis respiratory function respiratory muscle strength trunk control functional mobility
a study to evaluate the effect of deucravacitinib on quality of life in participants with plaque psoriasis in a community setting

Conditions: Psoriasis

Summary: the purpose of this study is to evaluate the effect of deucravacitinib on quality of life (qol) in participants with plaque psoriasis in a community setting.


Eligibility criteria:
inclusion criteria * men and women diagnosed with stable plaque psoriasis for 6 months or more. stable psoriasis is defined as no morphology changes or significant flares of disease activity in the opinion of the investigator. * deemed by the investigator to be a candidate for phototherapy or systemic therapy. * ≥ 3% of body surface area (bsa) involvement at the screening visit and day 1 * dermatology life quality index (dlqi) score \> 5 at the screening visit and day 1 * moderate-to-severe plaque psoriasis as defined by static physician global assessment (s-pga) ≥ 3 at the screening visit and day 1 exclusion criteria: target disease exceptions: * non-plaque psoriasis (that is, guttate, pustular, erythrodermic, palmoplantar only involvement or drug-induced psoriasis) at screening visit or day 1 other protocol-defined inclusion/exclusion criteria apply.

Keywords: plaque psoriasis deucravacitinib bms-986165 health related quality of life (hrqol) qol (quality of life) sotyktu
safety and efficacy of multiple daily dosing of oral lff571 in patients with moderate clostridium difficile infections

Conditions: Moderate Clostridium Difficile Infection

Summary: this study will assess the safety and efficacy of multiple daily dosing of oral lff571 in patients who have moderate clostridium difficile infections.


Eligibility criteria:
inclusion criteria: * males and females between 18 and 90 years of age, inclusive. * diagnosed with primary episode or first relapse of moderate c. difficile infection. received ≤24 hours of therapy effective for c. difficile infection prior to enrollment. exclusion criteria: * severe c. difficile infection * expected to require more than 10 days of c. difficile infection treatment. * more than one prior episode of c. difficile infection within the prior 3 months. * use of anti-peristaltic drugs (including tincture of opium, metoclopramide, loperamide),, cholestyramine, or colestipol other protocol-defined inclusion/exclusion criteria may apply

Keywords: clostridium difficile, c. difficile, cdi, clostridium difficile-associated disease, cdad, pseudomembranous colitis, pmc, antibiotic-associated diarrhea
the effect of obesity on lung functioning

Conditions: Obesity; Asthma

Summary: this research study is looking at the effects of weight loss, due to surgery or structured weight-loss program on lung function, inflammation in your body and lungs, asthma and asthma symptoms. this study is important because we will be better able to understand the effect of weight on lung functioning and asthma. approximately 20 research subjects will be enrolling in this study at national jewish. adults with asthma who has elected to undergo weight-reduction surgery may qualify for the participation. involvement will last about 1 year.


Eligibility criteria:
inclusion criteria: * adults (≥18yr) who report a physician's diagnosis of asthma and have taken any asthma medication within the last 2 weeks. * obesity (body mass index (bmi) ≥40, or ≥35 with comorbidities, as per published guidelines for qualification for bariatric surgery). * planned weight-loss surgery or structured weight-loss plan. exclusion criteria: * tobacco use within one month. * qualifying lung-functioning. * qualifying oxygen saturation levels. * use of systemic corticosteroids (prednisone) within one month. * presence of another chronic lung disease besides asthma (copd, bronchiectasis, ild, sarcoidosis, etc). * presence of another chronic systemic inflammatory disease (rheumatoid arthritis or other connective-tissue disease, chronic infection such as osteomyelitis, inflammatory bowel disease, chronic active hepatitis, etc). subjects with osteoarthritis, stable coronary artery disease, hypertension, or diabetes mellitus will not be excluded. * presence of malignant neoplasm within the last 3 years (with the exception of non-melanoma skin cancer). * clinically significant left or right ventricular dysfunction. * severe pulmonary hypertension (high blood pressure). * untreated obstructive sleep apnea: * subjects with a current diagnosis of sleep apnea not being treated with cpap or bipap will be excluded. * subjects with a current diagnosis of sleep apnea being treated adequately (as determined by the investigators) will be included. * prader-willi syndrome * a known endocrinopathy causing obesity (e.g., cushing's syndrome).

Keywords: obesity bariatric surgery weight loss surgery asthma
memoryxl effects on mild cognitive impairment patients

Conditions: Mild Cognitive Impairment

Summary: a vitamin nutriceutical, memory xl, has been shown to provide maintenance of cognitive status in mild, moderate, and severe alzheimer's disease patients (2 publications by t. shea). because this nutriceutical is now patented by the univ. of mass., other trials at that institution may be considered a conflict of interest. therefore, a study of its effects on mild cognitive impairment (mci) patients will be conducted by pi who is not affiliated with univ. of mass. or with dr. shea. the study hypothesis is: memory xl will maintain or improve the cognitive and behavioral status of patients diagnosed with mci during the year of participation in the study; normally, 10-25% of mci patients convert to mild alzheimer's dementia each year.

this irb-approved study is a randomized double blind study of patients diagnosed with mild cognitive impairment (mci) in the center for alzheimer's and neurodegenerative disorders (cando) at vamc in oklahoma city. dr. shea provided the pills (nutriceutical and placebos) from the same batches he used in former studies of alzheimer's disease patients (produced by nutricap labs, farmingdale, ny). pills were dispensed by the okc vamc research pharmacist, using a random numbering system. the pi completed five cognitive testing sessions, lasting 1 to 1.5 hours, for each subject during the 12 months of participation in the study. subject's spouse or family member completed 4 questionnaires about the subject's behavioral changes, and kept daily records of the times each day when the subject ingested the study pill assigned by the pharmacist. all subjects are patients in the vamc memory loss clinic (cando) who are monitored by their neurologists (2 co-investigators in this study).

Eligibility criteria:
inclusion criteria: * mci patients diagnosed at the vamc center for alzheimers and neurodegenerative disorder (cando). * clinical dementia rating (cdr) score of 0.5. * fluent in english. * able to ambulate to the outpatient clinic and research laboratory * have sight and hearing levels sufficient to complete neuropsychological testing. * free from bipolar disorder and terminal illnesses such as cancer. * must live with a spouse or adult relative who will record nutriceutical ingestion daily. * subjects will be consecutively diagnosed patients from all ethnic groups. exclusion criteria: * patients from protected categories such as prisoners and pregnant women. * any mci subject who develops a life-threatening disease such as terminal cancer, stroke, brain trauma, debilitating heart attack, etc. * indication of inability to make decisions regarding study participation.

Keywords: memory xl mild cognitive impairment cognitive status
a qualitative study of delays in hospital admission in patient with acute stroke

Conditions: Acute Ischemic Stroke

Summary: to identify the circumstance during decision making processes to seek medical help in patients with symptoms of acute ischemic stroke.


Eligibility criteria:
inclusion criteria: * patients with confirmed acute ischemic stroke by brain image and were able to communicate in mandarin or taiwanese. exclusion criteria: * patients who had cerebral hemorrhage, aphasia, cognitive dysfunction or severe stroke with unstable vital sign.

Keywords: qualitative study stroke 20 patients, family or caregivers acute ischemic stroke delayed to receive thrombolytic therapy.
a study on a new staining method (c4d staining) of transplanted kidney biopsies

Conditions: Kidney Transplantation; Graft Rejection

Summary: patients who had received kidney transplantation may suffer from rejection. recently, positive staining for c4d in kidney biopsies of malfunctioning transplant kidney is increasingly recognized as an important prognostic indicator of poorer long-term kidney outcome. data is, however, lacking in hong kong.


Eligibility criteria:
inclusion criteria: * all renal allograft biopsies performed in princess margaret hospital (pmh) during the period 1st april 2003 to 31st august 2005 for unexplained acute renal dysfunction (creatinine rise from baseline by ≥ 20%) or delayed graft function in the immediate post-transplantation period were included in the study. both cadaveric and living-donor transplant allografts were included. exclusion criteria: * patients who were \< 18 years' old at the time of renal biopsy or whose records were so incomplete that preclude meaningful analysis

Keywords: delayed renal graft function acute renal allograft dysfunction