Kornimate/medical-research-clean huggingface dataset:
effects of action observation therapy on fine motor skills of upper limb functions in chronic stroke patients.

Conditions: Chronic Stroke

Summary: this study will be conducted to evaluate the outcomes of action observation therapy on fine motor skills of affected upper limb among patients with chronic stroke.

the data for study will be collected for the duration of 5 months, data will be collected at 1st, 4th, 8th, 12th and then at 16th week of follow up. it is a randomized control trial. patients will be selected by consecutive sampling from ittefaq hospital trust, lahore. all patients were right handed prior to stroke. screening tools used will be canadian neurological scale, the mini-mental state examination (mmse), the bell barrage test, and the ideomotor apraxia test (spinnlerrognoni).tests for assessment will be fugl-meyer test (fm) (of the upper limb), frenchay arm test (fat), box and block test (bbt), modified ashworth scale (as) and functional independence measure motor items (fimm). the spss version 21 will be used for analyzing data. the descriptive data will be expressed in frequency and percentages, while within the group differences will be measured by mixed model anova.

Eligibility criteria:
inclusion criteria: * first-ever stroke, * enrolled 6 months after the event onset with ischemia or primary hemorrhage. * all patients were right handed prior to stroke. exclusion criteria: * posterior circulation infarction, * subarachnoid hemorrhage, * severe forms of neglect and anosognosia (number of errors in bell barrage test≥15) * impaired comprehension (token test score ≤ 17) * history of endogenous depression or serious psychiatric disorders, and * severe visual deficits (restricting the access to visual stimuli).
pilot study on the evaluation of irreversible electroporation technique in infiltrating perihilar cholangiocarcinoma

Conditions: Cholangiocarcinoma; Interventional Imaging

Summary: the aim of the study is to evaluate the feasibility of irreversible electroporation in the treatment of locally advanced cholangiocarcinoma. this technique would allow to treat the unresectable part of the tumor to make it more accessible for a secondary surgery.


Eligibility criteria:
inclusion criteria: * 18-75 years old * patient with infiltrating cholangiocarcinoma of the gallstone convergence considered as unresectable on the pre-operative imaging data performed during the month preceding inclusion, and in multidisciplinary consultation meeting specialised in digestive oncology * histologically (or cytologically) proven tumor of less than 4 cm of the largest diameter * world health organization performance index 0 or 1 * no history of other cancer, except baso-cellular skin carcinoma or epidermoid cervix cancer or any other cancer in complete remission for more than 3 years * no prior radiotherapy for cholangiocarcinoma * biological analyses performed during the month preceding inclusion : hepatic enzymes (ast and alt \ 50ml/min); bilirubin \ 9g/dl, leucocytes \>3500/mm3, platelets \>75000/mm3, prothrombin rate \>70% * signature of the informed consent exclusion criteria: * cholangiocarcinoma of more than 4cm diameter or resectable according tio the imaging data * severe and/or uncontrolled (cardiac, pulmonary, renal, liver decompensation...) visceral failure, in the 6 months preceding the study * visceral metastases or peritoneal carcinosis * history of cancers except if remission for more than 3 years, in-situ cancer, epidermoid or baso-cellular cancer * metal biliary prothesis non extractable * patient with history of epileptic events * history of myocard infarction for less than 6 months * unstabilised coronary disease for at least 6 months * cardiac rhythm trouble or qt space above 550ms without treatment * patient eligible to liver transplant * patient naive of chemiotherapy * patient with a pacemaker, an implanted automatic defibrillator or an automatic electronic device or an electronic device with metal pieces * patient with contra-indication to the use of nanoknife system * history of hypersensitivity to gadolinium or to iodized contrast product not allowing a suitable radiologic monitoring * refusal or language or psychic incapacity to sign the informed consent * subject who cannot submit to the constraints of the protocol (subjects for which an mri or a scan is contra-indicated, claustrophobic subjects, non cooperative or not able to come to the follow-up visits) * concomitant participation to another study * persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, adults under legal protection. * women at age to procreate and not using effective contraception

Keywords: cholangiocarcinoma irreversible electroporation interventional radiology
rosiglitazone and plaque study for type 2 diabetes mellitus

Conditions: Non-insulin-dependent Diabetes Mellitus

Summary: this is a phase iiib, randomised, double blind, placebo controlled, study in patients with type 2 diabetes mellitus and coexisting vascular disease or hypertension. the total duration of the study will be approximately 60 weeks. the aim of this study is to examine the potential beneficial effects of rosiglitazone on carotid atheroma in patients with type 2 diabetes mellitus and coexisting vascular disease or hypertension. it is hypothesised that treatment with rosiglitazone will lead to an decrease in plaque size. in addition, it is hoped that rosiglitazone will have a positive effect on plaque composition and stability.


Eligibility criteria:
inclusion criteria: * type 2 diabetes. * co-existing vascular disease. * at least 6 months of statin or fibrate therapy. * hba1c \<10% at screening and with at least one atheromatous plaque causing 10-95% narrowing of the internal carotid artery. exclusion criteria: * patients with \>2 concomitant oral anti-hyperglycaemic agents within 3 months of screening. * previous exposure to a thiazolidinedione. * history of chronic insulin use. * use of investigational drug within 30 days. * systolic blood pressure (bp) \> 170 mmhg or diastolic bp \>100 mmhg. * severe or unstable angina. * history of: gangrene, tia, stroke, hepatic disease, alcohol or drug abuse, surgery of the carotid arteries or claustrophobia.

Keywords: diabetes rosiglitazone plaque
helicobacter pylori first-line treatment in patients allergic to penicillin

Conditions: Helicobacter Pylori Infection

Summary: the purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and tinidazole-tetracycline-containing quadruple regimens for the primary treatment of helicobacter pylori infection in patients allergic to penicillin.

helicobacter pylori(h.pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer. strongly evidence supports that h.pylori eradication is an effective approach to reduce the incidence of those pathologies.however,helicobacter pylori eradication is a challenge in patients allergic to penicillin. therefore, the investigators aim to assess and compare the effectiveness of levofloxacin-tetracycline -containing and tinidazole-tetracycline-containing quadruple regimens for the primary treatment of helicobacter pylori infection in patients allergic to penicillin.

Eligibility criteria:
inclusion criteria: * patients aged 18-70 with h. pylori infection. * patients allergic to penicillin. exclusion criteria: * patients with previous h. pylori eradication therapy. * patients treated with histamine-receptor antagonist, proton pump inhibitor, bismuth and antibiotics in the previous 4 weeks. * patients with gastrectomy, acute gastrointestinal bleeding and advanced gastric cancer. * patients with known or suspected allergy to study medications. * currently pregnant or lactating. * inability to provide informed consent

Keywords: allergic penicillin helicobacter pylori eradication tetracycline
radiation therapy after surgery in treating women with early stage breast cancer

Conditions: Breast Cancer

Summary: rationale: radiation therapy uses high-energy x-rays to damage tumor cells. it is not yet known which regimen of radiation therapy is more effective following surgery for breast cancer. purpose: randomized phase iii trial to compare the effectiveness of two regimens of radiation therapy following surgery in treating women who have early stage breast cancer.

objectives: * determine the benefits of radiotherapy schedules using fraction sizes larger than 2.0 gy in terms of normal tissue responses, local-regional tumor control, quality of life, and economic consequences in women prescribed postoperative radiotherapy for early stage breast cancer. outline: this is a randomized, multicenter study. patients are stratified according to center, type of surgery (mastectomy vs local excision), and breast boost (yes vs no). patients are randomized to 1 of 2 treatment arms. * arm i: patients receive radiotherapy 5 times a week for 5 weeks for a total dose of 50 gy. * arm ii: patients receive radiotherapy 5 times a week for 3 weeks for a total dose of 40 gy. a breast boost is recommended in both arms for patients with microscopic evidence of invasive or in situ cancer at, or within 1 mm of, a resection margin. these patients receive radiotherapy for 5 fractions in 1 week for a total boost dose of 10 gy. quality of life is assessed at baseline and then at 6, 12, 24, and 60 months. patients are followed annually for up to 20 years. peer reviewed and funded or endorsed by cancer research uk projected accrual: a total of 1840 patients (920 per arm) will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed invasive unilateral breast cancer * t1-3, n0-1, m0 at presentation * complete macroscopic excision of tumor by breast conserving surgery or mastectomy * no immediate breast reconstruction * no requirement for axillary radiotherapy after greater than a level 1 axillary dissection or after greater than 10 lymph nodes have been removed * not enrolled on secrab or oscar trials * hormone receptor status: * not specified patient characteristics: age: * 18 and over sex: * female menopausal status: * not specified performance status: * not specified life expectancy: * not specified hematopoietic: * not specified hepatic: * not specified renal: * not specified prior concurrent therapy: * prior neoadjuvant, or primary medical, therapy is allowed provided subsequent surgery confirms complete macroscopic excision of residual primary tumor biologic therapy: * not specified chemotherapy: * at least 2 weeks since prior cytotoxic agents * no concurrent chemotherapy endocrine therapy: * not specified radiotherapy: * see disease characteristics surgery: * see disease characteristics

Keywords: stage i breast cancer stage ii breast cancer stage iiia breast cancer
residential ventilation systems and filtration for asthma control in adults

Conditions: Asthma; Pollution; Exposure

Summary: the goal of this study was to investigate the effectiveness of three common approaches to upgrading residential mechanical ventilation systems in existing homes for improving asthma-related health outcomes, reducing indoor pollutants of both indoor and outdoor origin, and maintaining adequate environmental conditions and ventilation rates in a cohort of adult asthmatics in existing homes in chicago, il.

the breathe easy study utilized a quasi-randomized, within-subjects, parallel-group, pre-post intervention study design with four weeklong periods of indoor air quality (iaq) and indoor environmental data collection for approximately one year before the installation of mechanical ventilation systems, followed by four weeklong periods of iaq and indoor environmental data collection for approximately one year after the installation of mechanical ventilation systems, conducted from july 2017 through march 2020 in chicago, il. with the nature of a healthy home intervention study by installing residential mechanical ventilation systems within the timeframe, each participant received interventions in the middle of the study period, including continuous exhaust-only systems; intermittent powered central-fan-integrated-supply (cfis) systems; or continuous balanced systems with an energy recovery ventilator. thus, each participant served as their own control and there was no formal control group that did not receive intervention nor did they receive a sham/placebo intervention. primary health outcome, asthma control, was assessed by using the asthma control test (act) every month, and quality of life, stress, and other asthma-related health outcomes were assessed via the baseline and end-line surveys.

Eligibility criteria:
inclusion criteria: * age: 18 - 90+ years. * english speaking and writing. * able to provide consent. * chicago resident. * households with at least one occupant with asthma * non-smoking houses * participant-owned houses * participant's agreement to surveys and iaq monitoring over 2 years exclusion criteria: * houses outside chicago, il usa * houses with significant health and safety issues

Keywords: adult asthma home intervention mechanical ventilation air filtration indoor air pollution exposures
recognition of serious infections in the elderly

Conditions: Infection

Summary: the aim of this diagnostic accuracy study is to develop a clinical prediction rule based on signs, symptoms, patient characteristics and blood tests, to be used in ambulatory care to help physicians safely rule out a serious infection in an older patient. it will be performed in general practices and emergency care departments across flanders (belgium).

this is a cross-sectional diagnostic cohort study in older adults presenting to ambulatory care, including a follow-up period of 30 days. this study will be used to construct an algorithm consisting of clinical features and blood test results to identify serious infections. the study will run in ambulatory care in flanders. recruitment is expected to last 2.5 years, with each patient entering the study only once. older adults will be approached for possible participation in the study by practice staff. there is only one study visit. those who agree to participate via written informed consent will have demographics and clinical features recorded. a blood sample will be taken in all participants on study entry. follow-up information for all participants will be collected using electronic medical record notes (emd) and patient diaries. treatment and other management decisions will be left to the treating physicians' discretion.

Eligibility criteria:
inclusion criteria: * aged 65 years or older * presenting to a general practice with an acute illness with a maximum duration of 10 days since onset * suspicion of infectious disease (this may include suspicion of an acute exacerbation of copd) * patient or proxy of the patient is willing and able to give informed consent for participation. exclusion criteria: the participant may not enter the study if any of the following apply: * too clinically unstable to waste time on study procedures * indwelling catheter in situ * immunocompromised or currently receiving medication for systemic immune-suppression, including corticosteroids * being admitted to hospital for longer than 24 hours less than 7 days before study entry, or having undergone surgery in the previous 30 days * living in a nursing home (both short term and long term stay) (only in general practice cohort) * patient was already included in the study

Keywords: geriatric diagnosis ambulatory care general practice emergency care
transcatheter aortic valve intervention-live transmission

Conditions: Aortic Valve Disorder

Summary: the primary objective of this clinical trial is to evaluate safety of patients who underwent transcatheter aortic valve intervention (tavi) during a live case or video-taped transmission as compared to those without procedure transmission.

a series of sites from outside the us, where the edwards-sapien and corevalve devices are approved for commercial sale and implantation, will be recruited to retrospectively identify and extract in-hospital data of a patient who underwent tavi during a live or video-taped procedure and a matched patient who underwent tavi without transmission of the procedure.

Eligibility criteria:
cases inclusion criteria: * subjects \> 18 years of age, male or female * subject had live case or video-taped transmission of tavi procedure with: edwards-sapien transfemoral approach, edwards-sapien transapical approach, or corevalve transfemoral approach controls inclusion criteria: * subjects \> 18 years of age, male or female * subject underwent tavi without procedure transmission and had: edwards-sapien transfemoral approach, edwards-sapien transapical approach, or corevalve transfemoral approach * subjects will be matched to cases upon the following: * sts score +/- 2points * date of tavi procedure +/- 4weeks * the first attending for the tavi procedure * access site for tavi

Keywords: transcatheter aortic valve intervention (tavi) live case transmission
expanded access to burosumab

Conditions: X-linked Hypophosphatemia; Tumor-Induced Osteomalacia

Summary: individual patient expanded access requests may be considered for patients who have no other treatment options

expanded access may be available outside of the us in countries prior to approval by the local regulatory agencies. for full details, please visit the links provided below.

Eligibility criteria:
inclusion criteria: - exclusion criteria: -

Keywords: expanded access compassionate use xlh tio
a study of the impact of an early biopsy in patients treated with cellcept (mycophenolate mofetil) after kidney transplantation

Conditions: Kidney Transplantation

Summary: this 2 arm study will evaluate the impact on fibrosis at week 52 of an early biopsy, in patients who have received a kidney transplant from an expanded criteria donor. patients will be randomized to one of two groups; the first group will have a biopsy at day 10, and the second group will receive standard management. all patients will be given cellcept as standard of care. the anticipated time on study treatment is 1 year, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * in receipt of an initial cadaveric kidney transplant; * in receipt of graft with biopsy; * in receipt of a 'marginal' kidney transplant. exclusion criteria: * in receipt of a second kidney transplant; * in receipt of a multi-organ transplant or a double kidney transplant; * malignant tumor, or a history of cancer in past 5 years, other than successfully treated basal cell or spinocellular cancer or cancer in situ of cervix; * replicating hepatitis b and/or c, or hiv positive serology.
transabdominal preperitoneal inguinal hernia repair

Conditions: Hernia, Inguinal; Laparoscopy

Summary: the present study seeks to determine whether improved visual acuity and enhanced flexibility of the robotic platform results in a reduced surgical stress response and an improvement in indices of surgical outcome measures for simple and complex inguinal hernia repair

complex inguinal hernia repair is challenging and requires both advanced skills in laparoscopic surgery and knowledge about the complex anatomy of the inguinal area. whereas the repair of a small inguinal hernia usually is simple and straightforward, complex hernias (large inguinoscrotal and recurrent hernias) constitute a surgical challenge due to the risk of damage of the neurovascular structures in the inguinal area. it requires advanced laparoscopic skills to reduce the hernial sac in patients with large lateral hernias, where the hernial sac often extends deep into the scrotum in close vicinity to the spermatic cord and the testicular artery. this dissection is difficult with conventional laparoscopy, which may explain the risk of chronic pain, testicular hypotrophy and hernia recurrence. the aim of the study is to determine whether rtapp of complex inguinal hernias is associated with a lower surgical stress response and a lower risk of postoperative complications compared to laparoscopic tapp.

Eligibility criteria:
inclusion criteria: * asa 1- 3 * clinical or radiologic diagnosis of inguinal hernia (unilateral, bilateral, recurrent, inguinoscrotal) * eligible for a laparoscopic procedure * informed concent exclusion criteria: * incarcerated inguinal hernia requiring emergency surgery * pregnancy * patients with chronic pain due to arthritis, migraine or other illness requiring regular intake of pain relieve (paracetamol, nsaid etc) * active cancer * history of psychiatric or additive disorder that prevent the patient from participating in the trial * co-existing inflammatory disease * co-existing immunological disease that requires medication of any kind

Keywords: adult robotic surgical procedures abdomen
trial comparing radial and femoral approach in primary percutaneous coronary intervention (pci)

Conditions: ST Elevation Myocardial Infarction

Summary: percutaneous coronary interventions (pcis) from the femoral approach have more bleeding complications related to access site in comparison to the radial approach in patients with acute coronary syndrome (acs). major bleeding and access site complications have an important role in results of pci for acs and lead to higher morbidity and mortality. primary pcis in st elevation myocardial infarction (stemi) are associated with more aggressive antithrombotic treatment than in elective or semi-urgent interventions. currently, both radial and femoral approaches are routinely used for primary pci in stemi. however, only non-randomized studies and registries or small randomized single center studies comparing both approaches in primary pci have been published until now. the aim of stemi-radial trial is to evaluate potential reduction of bleeding complications in the radial approach primary pci compared to femoral approach in randomized, multicenter study.


Eligibility criteria:
inclusion criteria: * age over 18 years * admission for stemi less than 12 hours after onset of symptoms 1. patients have typical chest pain for at least 20 minutes and have ecg changes typical for stemi (st elevation ≥ 2 mm in two continuous precordial leads or st elevations ≥ 1 mm in two limb leads or new left bundle branch block) or ecg changes compatible with true posterior mi. 2. patients are planned to be treated with primary pci * ability to sign written informed consent exclusion criteria: * killip iv class or unconsciousness * patient disagreement * prior aortobifemoral bypass * absence of both radial or femoral artery pulsation * participation in another clinical trial randomizing acs patients using antithrombotic drug. * negative allen's test or barbeau test type d * treatment with oral anticoagulants

Keywords: myocardial infarction primary percutaneous coronary intervention radial bleeding