Kornimate/medical-research-clean huggingface dataset:
sirtuin 3 and sirtuin 7 in systemic sclerosis

Conditions: Systemic Sclerosis

Summary: systemic sclerosis (ssc) is a systemic autoimmune disease in which inflammation and fibrosis play a crucial role and lead to severe damage and failure of multiple organs such as the skin, joints, tendons, gastrointestinal tract, lungs, heart, blood vessels, and kidneys. it primarily affects women but disease is often more severe in males.

systemic sclerosis (ssc) is a systemic autoimmune disease in which inflammation and fibrosis play a crucial role and lead to severe damage and failure of multiple organs such as the skin, joints, tendons, gastrointestinal tract, lungs, heart, blood vessels, and kidneys. it primarily affects women but disease is often more severe in males. sirtuins are a class of nicotinamide adenine dinucleotide-consuming enzymes that are implicated in numerous biological pathways . sirtuins are considered among the most promising targets for modulating aging-associated cellular and molecular processes and disease pathologies , the majority of studies have shown decreased sirt expression in tissues and fibroblasts from patients with ssc compared to controls and in experimental fibrosis in mice . decreased sirt3 levels and activity were observed in fibrotic areas of ssc and ipf lung tissues and ssc skin biopsies and explanted fibroblasts compared to controls , wyman et al investigated the expression of all seven mammalian sirts in lung tissues and fibroblasts from patients with ssc and ipf and found a tendency for sirts to be decreased in patients with fibrosis compared to controls , with a particularly notable decline in sirt7 .

Eligibility criteria:
inclusion criteria: * patients with systemic sclerosis diagnosed by 2013 acr\\eular classification criteria of systemic sclerosis * patients' age \>18 * 25 rheumatoid arthritis patients as a control . exclusion criteria: -overlap or mixed connective tissue diseases.
reliability and validity of the turkish version of the stroke exercise preference inventory

Conditions: Stroke

Summary: with this study, it will be proven whether the turkish version of the stroke exercise preference inventory is valid and reliable in evaluating the exercise preferences of individuals who have had a stroke.

version, validity, and reliability studies are frequently encountered in the literature. however, there is no scale that evaluates the exercise preferences of individuals who have had a stroke among the measurement tools whose turkish version, validity, and reliability studies have been carried out. the stroke exercise preference inventory is an outcome scale for questioning exercise preferences in individuals who have had a stroke. it is functional for the development and planning of exercise programs for individuals who have had a stroke. this scale will both fill the gap in the turkish literature in terms of the parameters it evaluates and will be the first in this context. in terms of its application, it is a useful inventory in this field. considering the absence of a measurement tool developed in turkish or adapted to turkish for the assessment of exercise preferences of individuals with stroke, the aim of this study is to evaluate the validity and reliability of the turkish version of the self-administered stroke exercise preference inventory, designed to question exercise preferences in turkish individuals with stroke, to perform cross-cultural adaptation study, and to question the suitability of the turkish version for turkish society and the effectiveness of its clinical use.

Eligibility criteria:
inclusion criteria: * who have had a stroke, * good cognitive status, * can speak, read, write turkish. exclusion criteria: * pregnant, * who cannot speak, read or write turkish.

Keywords: reliability validity stroke stroke exercise preference inventory
compression anastomosis using the compression anastomotic ring-locking procedure (carp)

Conditions: Cancer; Polyp

Summary: the intestinal ends must be rejoined after colonic resection. conventional methods include sutured and stapled anastomoses, which is associated with 3-6% leakage after colonic surgery. the leakage of an anastomosis can cause serious consequences, such as abdominal infections and/or sepsis. early detection of anastomotic leakage is the best way to avoid serious abdominal infections. the methods that are used today to detect leaks are unfortunately not very accurate. these methods include monitoring symptoms, temperature, and crp-levels, and performing abdominal examinations and tomography scans. because of the difficulties in objectively assessing these parameters, the anastomotic leaks are often diagnosed late. when reoperation is required, a permanent stoma may be made at the level of the sigmoid colon. the carp system has been developed to achieve a safe anastomosis. the carp is designed to providing an improved contact surface between the two intestinal ends and the ability to precisely investigate the anastomosis during and after surgery using the catheters of the carp system. standardized use of the carp to anastomose the large intestine may provide significant advantages in the field of colorectal surgery.


Eligibility criteria:
inclusion criteria: 1. age between 18 - 90 years (male or female) 2. planned resection due to benign or malign disease in the left colon 3. cognitive ability to take part in the study and understand the information he/she receives about participating in the study exclusion criteria: 1. urgent medical condition requiring immediate care 2. health condition classified as asa iv 3. albumin level less than 25 g/l 4. inflammatory bowel disease (ibd) (ulcerative colitis or crohn´s disease) 5. disease that requires more than one anastomosis during the surgical procedure 6. treatment with cortisone and/or other immunosuppressive medications less than one month before surgery 7. contraindications to general anaesthesia 8. cognitive ability that limits the patient's ability to take part in the study and understand the information he/she received about participating in the study, or the patient does not agree to join the study

Keywords: anastomosis compression colon
motivate af motivational support for patients with atrial fibrillation to promote weight loss

Conditions: Atrial Fibrillation

Summary: this study is designed to look at the impact that support and motivation has on patients with atrial fibrillation's ability to lose weight and maintain this. we believe that weight loss has a positive impact on the reduction of symptoms of atrial fibrillation and can decrease the likelihood of the arrhythmia returning following cardio version. this study is designed for patients who have a diagnosis of atrial fibrillation and have a body mass index greater than 27. in the study, we plan to provide support and motivation to patients with atrial fibrillation to encourage weight loss. there are several weight loss strategies available to follow. information will be provided about each strategy to encourage informed choices. if the initial strategy chosen is not working, this can be change to a more suitable one as required. follow up will be by telephone at 2 and 4 weeks then every month thereafter where you will be asked your weight and to clarify the weight loss strategy you are following. you will be seen at 6 and 12 months where you will have an ecg, bp check and your weight measured. a final telephone assessment will take place at 24 months. we hope that the research will in the future help patients with atrial fibrillation manage and maintain their weight loss to improve their symptoms and prevent recurrence of the arrhythmia. the results of this study could potentially change practice in our centre by providing more structured weight loss clinics for patients with atrial fibrillation


Eligibility criteria:
inclusion criteria: * age ≥18 years * bmi\>27 * symptomatic af * committed to monthly follow up phone calls and bi annual visits. exclusion criteria: * any co morbidity that would reduce life expectancy to within the year. * unable to commit to follow up. * patients recruited to weight loss studies that are on going
effects of aerobic training program on liver functions

Conditions: Liver Functions

Summary: the liver plays a central role in energy exchange, protein synthesis as well as the elimination of waste products from the body. the optimal functioning of the liver is essential for athletic performance. it becomes necessary to maintain the enzymes of the liver at an optimal level so that liver cells can be protected from inflammation or damage. this paper investigated the effects of a twelve-week aerobic exercise program on the liver function of adult athletes. a total of thirty (30) healthy male athletes aged 21 to 24 were recruited for this study and kept in two equal groups. the control group was kept under rigorous supervision and did not participate in any special activities. the experiment group was well-versed in their assigned training program and solely performed the experimental procedure for twelve (12) weeks. evaluation of all patients in both experimental and control groups was carried out before and after the treatment program by measuring the levels of (alkaline phosphate, ast/sgot, alt/sgpt, bilirubin total/indirect/direct, albumin, globulin, and total protein) respectively using standard methods by collecting blood samples, 5 mls each of baseline into lithium heparin containers for estimation of above biochemical parameters at the pathology laboratory accredited by national accreditation board for testing and calibration laboratories accredited (nabl, india).


Eligibility criteria:
inclusion criteria: * male * age: 21-24 years * healthy * athletes exclusion criteria: * history of severe illness, * surgery, or damage to liver, * fatty liver disease, * cirrhosis, * blood infections, * neuromuscular illnesses, * or the presence of any disorders such as fever, high blood pressure, high blood sugar

Keywords: fatty liver physical activity treadmill exercises
combination bisphosphonate and anti-angiogenesis therapy with pamidronate and thalidomide

Conditions: Multiple Myeloma

Summary: the purpose of this research is to study how helpful the combination of thalidomide and pamidronate is in controlling multiple myeloma and to study any side effects that may be experienced.

recently, laboratory research found that thalidomide can inhibit the formation of new blood vessels that are necessary for the growth and spread of cancer. in order to grow and increase in size, tumors require new blood vessels to supply them with the necessary blood to grow. if we can prevent these new blood vessels feeding the tumor from being formed by using thalidomide we might slow or stop the growth of the tumor. this concept is called "anti-angiogenesis". it is hoped that thalidomide will slow or stop the growth myeloma. however, it cannot be guaranteed that you will benefit if you take part in this study. the treatment you receive may even be harmful.

Eligibility criteria:
inclusion criteria: * patients must have a diagnosis of multiple myeloma with poor hematopoietic reserve (platelet count \<100,000 or inability to collect adequate pbsc to support autologous transplant (4x106 cd34+cells/kg or wbc \<2,000) * patients must not be eligible for uark 98-035 * patients must be at least 6 weeks beyond previous chemotherapy * all patients must be informed of the investigational nature of this study and must sign a written informed consent in accordance with uams human research advisory committee and federal guidelines exclusion criteria: * prior bisphosphonate therapy within 30 days prior to study entry * serum creatinine \> 5 mg/dl, ascites, or serum direct bilirubin \> 2.5 mg/dl * prior plicamycin or calcitonin within 2 weeks of study entry * severe cardiac disease, unstable thyroid disease, or epilepsy

Keywords: multiple myeloma pamidronate thalidomide refractory myeloma bisphosphonates aredia
prevalence of genital hpv infection in males following introduction of universal male hpv vaccination

Conditions: Human Papillomavirus

Summary: this study will examine how common hpv infection is in teenage males in australia before and after the introduction of universal school based vaccination of males in australia.

males aged 17 to 19 in australia will be recruited from 2014. men will undergo sampling from the penis for hpv. the prevalence of hpv infection will be determined in 2014-2015 and compared to the prevalence in 2016-2017.

Eligibility criteria:
inclusion criteria: * male * aged 17 to 19 * able to complete study requirements * residing in australia from 12 years of age exclusion criteria: -males reporting sex with males in the past 12 months

Keywords: prevalence hpv human papillomavirus vaccination
yale swallow protocol in extubated patients

Conditions: Dysphagia

Summary: the purpose of this study is to determine if the yale swallow protocol is an effective screen for aspiration in recently extubated patients.

dysphagia is prevalent in recently extubated patients with estimates ranging from 29-84% of recently extubated patients having some form of dysphagia with elevated risk for silent aspiration.one challenge providers face when managing post extubation dysphagia (ped) is that there are no best practice guidelines on how to evaluate for ped, specifically how to evaluate for silent aspiration (aspiration without cough response). one method that has been suggested is the yale swallow protocol (ysp), a pass/fail screen for aspiration consisting of a three ounce water challenge as well as a brief cognitive screen and oral motor exam. the assumption of the ysp is that silent aspiration (aspiration without a cough response) is volume dependent. this is based on a study of over 4000 patients that underwent both a fees (5ml puree and 5ml liquid boluses) and a 3oz water challenge. results from previous literature indicated that the 3oz water swallow had a high sensitivity for detecting aspiration (98%). this was again studied with a double blind research design with 25 patients, comparing results of the 3oz water challenge with results of videofluoroscopic swallow study. this showed 100% sensitivity for detecting aspiration, 64% specificity, 78% positive predictive value, and 100% negative predictive value. however, no published study has evaluated the ysp in recently extubated patients and so it is unclear if the high sensitivity and specificity would be retained. investigators aim to determine the sensitivity and specificity of the yale swallow protocol in identifying aspiration in recently extubated patients.

Eligibility criteria:
inclusion criteria: 1. intubation greater than 24 hours 2. age 18 and older 3. all races 4. males and females 5. english speaking 6. swallow consult ordered by the team within 48 hours of extubation exclusion criteria: 1. known history of oropharyngeal dysphagia 2. contraindication for fees due to facial fractures, nothing by mouth (npo) status for other procedures, elevated bleeding risk, reduced level of alertness, or significant agitation. 3. allergy to dairy

Keywords: dysphagia aspiration ysp fees swallow problems
tumor detection using iodine-131-labeled monoclonal antibody 8h9

Conditions: CNS Cancer; Neuroblastoma; Sarcoma

Summary: the purpose of this study is to find out whether the monoclonal antibody 8h9 is useful in finding tumors in your body. antibodies are protein found naturally in blood. they can fasten themselves to bacteria and viruses. they can stimulate white cells and blood proteins to kill tumors. the antibody 8h9 was made from mouse white cells. the white cells that secrete this antibody have been made to live for ever. they manufacture large amounts of 8h9 for patient use. although other monoclonal antibodies have been safely tested in people, the antibody 8h9 has never been given to a human patient.

to test if intravenous injections of iodine-131 labeled murine monoclonal antibody 8h9 can detect primary and metastatic solid tumors. a total of 60 patients will be accrued over a period of 2 years.

Eligibility criteria:
inclusion criteria: * diagnosis of pediatric/adolescent solid tumor (including neuroblastoma, rhabdomyosarcoma, ewing's/pnet, osteosarcoma, brain tumors, desmoplastic small round cell tumor (dsrt) and other tumors that are 8h9-positive) confirmed by the mskcc department of pathology. * patient must have either recurrent disease or have \<20% chance of long term disease-free survival. * patient must be at least 1 year old. age can range from 1-50 years of age. * patients should have measurable or evaluable disease. for tumor types that are known to be 8h9-positive, patients can be imaged after the diagnosis is made, prior to definitive surgery or surgery to confirm tumor recurrence. * tumor tissue is or will be available for 8h9 immunostaining. for patients with tumor-types known to be 8h9-positive, surgical samples obtained after 131i- 8h9 imaging will be immunostained to confirm 8h9-reactivity. these tumor types include: neuroblastoma, rhabdomyosarcoma, osteosarcoma, dsrt, ewing's sarcoma/pnet), brain tumors (glioblastoma multiforme, mixed glioma, astrocytoma, ependymoma, medulloblastoma, schwannoma., meningioma). * if frozen tumor tissue is unavailable, and if bone marrow involvement is demonstrated by histology, 8h9 immunostaining by immunofluorescence will be carried out on patient's bone marrow. in this case, patients will be eligible for study if bone marrow 8h9 immunostaining is positive. exclusion criteria: * severe major organ toxicity. specifically, renal, cardiac, hepatic, pulmonary, gastrointestinal, and neurologic system toxicity should all be less than grade 2. patients with stable neurological deficits (because of their brain tumor) are not excluded. patients with \<= 3 hearing loss are not excluded. * clinically apparent infections. * history of allergy to iodine or mouse proteins. * patients previously treated with mouse monoclonal antibodies are not eligible unless they have no circulating hama. * pregnant women are excluded for fear of danger to the fetus. therefore negative pregnancy test is required for all women of child-bearing age, and appropriate contraception is used during the study period. * patient's own tumor is negative by 8h9 immunostaining.
analgesic effect of laser therapy in children

Conditions: Pain, Postoperative

Summary: pain management after tonsillectomy could be challenging, with different protocols and various outcome depending on individual patient; moreover, odynophagia due to surgery can, in extreme cases, lead to block oral fluid intake, ending in dehydration and thus hospitalization. a small pilot study demonstrated efficacy of photo-biomodulation (pbm) in managing pain after tonsillectomy and it suggests that pbm can be included in clinical practice. the present research aims to confirm and expand the findings from this study, being the first step in including pbm in clinical routine after tonsillectomy. use of this treatment, which is non-damaging, non-toxic and easy to supply to patients, could greatly improve individual quality of life after a surgical treatment; its use in the clinical practice could represent an advantage for the institute, leading to more patients' satisfaction, due to the lower pain sensation after surgery and quicker recovery time.


Eligibility criteria:
inclusion criteria: tonsillectomy or adenotonsillectomy due to apneic chronic snoring and/or obstructive sleep apnea and/or recurrent tonsillitis exclusion criteria: 1. american society of anesthesiologists (asa) score \> 2 2. neuropsychiatric co-morbidity 3. pro-hemorrhage coagulation disorders

Keywords: pain tonsillectomy laser therapy photo-biomodulation
acupuncture therapy for post-stroke mild cognitive impairment: a randomized controlled trial

Conditions: Post-stroke Mild Cognitive Impairment

Summary: 1. on the basis of previous studies, standardized randomized controlled clinical trials were conducted to observe the efficacy and safety of acupuncture in the treatment of mild cognitive impairment after stroke using the international rating scale, and the clinical experience was transformed into evidence. 2. according to the clinical outcomes reported by patients, the differences between chinese and western scales in evaluating mild cognitive impairment after stroke were compared. on the basis of "disease differentiation, syndrome differentiation and meridian differentiation", the syndrome differentiation and treatment system of mild cognitive impairment after stroke was preliminarily constructed, and the tcm syndrome prediction model was improved.


Eligibility criteria:
inclusion criteria: 1. meeting the diagnostic criteria: ① stroke diagnostic criteria: according to the diagnostic criteria of cerebral infarction and cerebral hemorrhage in the "chinese guidelines for the prevention and treatment of stroke (2021 edition)" issued by the national health commission, the diagnosis was confirmed by head ct or mri examination. ② mild cognitive impairment diagnostic criteria: according to the 2018 chinese guidelines for the diagnosis and treatment of dementia and cognitive impairment (5) : diagnosis and treatment of mild cognitive impairment. ③ tcm diagnostic criteria: according to the "tcm diagnostic efficacy criteria" issued by the state administration of traditional chinese medicine in 2012, the patients were diagnosed as dementia. 2. 40 years old ≤ age ≤75 years old, regardless of gender; 3. cognitive impairment occurred after stroke without other causes; 4. cognitive impairment within 6 months after stroke; 5. stable condition, clear consciousness, moca score \< 26 points; 6. those who were willing to participate in the study and signed the "informed consent". exclusion criteria: * brain ct or mri showed other lesions unrelated to stroke, or severe brain atrophy or leukoaraiosis; (2) serious complications (myocardial infarction, heart failure, malignant tumor, severe infection, mental illness, severe depression, epilepsy, etc.); * with obvious hearing impairment, visual impairment, aphasia and other inability to cooperate in the physical evaluation; (4) pregnant or intended to pregnant women, lactating women; ⑤ intolerance to acupuncture; ⑥ bleeding tendency and poor coagulation function.

Keywords: acupuncture therapy