Kornimate/medical-research-clean huggingface dataset:
impact of a double-reading animated film (child, parents) in preoperative on the anxiety of children upon arrival at the operating room

Conditions: Anxiety; Surgery; Pediatric ALL

Summary: preoperative anxiety affects 40 to 60% of children. a literature review concluded that effective preparation strategies must involve parents, must be appropriate to their age and proposed upstream of the intervention. a double-readinganimated film aimed at informative was created for the children and their parents/legal guardians in order to solve the problem of anxiety found at the arrival of children in the operating room.


Eligibility criteria:
inclusion criteria: * child boy or girl. * 3 to 7 years old. * programmed for: removal of tonsils, vegetations, paracentesis or installation of trans-tympanic aerators, pre-heliceal fistula, otoplasty, myringoplasty * scheduled intervention in the outpatient department of specialized surgeries or hospitalization of a postoperative night. * accompanied by an adult, french-speaking, whose child lives at home. * of which the holders of the parental authority formulated their non-opposition to the participation of their child and gave their signed agreement for the realization of videos of their child. * assent of the child for children aged 6 to 7 * parents affiliated to social security for the group under study only: - support available at home that can watch the movie on the internet exclusion criteria: * child having already had surgery. * presence of associated disability (blindness, profound deafness, autistic disorders). * child having anxiolytic treatment. * child to be operated within less than 2 days

Keywords: preoperative- child double-reading movie
sleep quality and risk of intubation in intensive care units patients with hypoxemic acute respiratory failure

Conditions: Sleep Quality; Hypoxemic Acute Respiratory Failure; Intubation Risk

Summary: the aim of the study is to evaluate the impact of sleep quality on intubation rate in intensive care units patients with acute respiratory failure


Eligibility criteria:
inclusion criteria: * acute respiratory failure * hypoxemia with pao2/fio2 ratio \< 300 mmhg * aged of 18 years or more exclusion criteria: * need of immediate intubation * need of vasopressor drugs * coma with glasgow scale \< 8 * acute respiratory failure linked to cardiogenic pulmonary oedema * chronic respiratory insufficiency * peripheral or central nervous system pathology * known psychiatric pathology or agitation * patient with decision of no intubation * patient refusal * pregnant or breastfeeding women * patient under legal guardianship or protection * patients with no health insurance coverage
ballet training in children with idiopathic coxa antetorta

Conditions: Femoral Anteversion

Summary: this study looks at how ballet training affects movement and personal feelings in children with a condition called idiopathic coxa antetorta.

increased femoral anteversion (ifa) occurs when the top of the thigh bone tilts forward more than normal. many healthy kids and teens aren't considered to have a problem with this as long as they show no symptoms, since it often corrects itself by the time they reach ages 12 to 14. however, experts believe this condition might lead to complications later in life. research indicates that children with ifa may be more prone to issues like kneecap misalignment, knee pain, and even arthritis as they grow older. this is likely due to the way their knees bend differently when they walk. kids with ifa often walk with their toes pointing inward, which increases their chances of tripping and falling. they may also experience pain that interferes with their daily activities. it is assumed that strengthening the hips and improving hip flexibility could help reduce the need for compensatory movements, ultimately lowering the risk of tripping, falling, and experiencing pain in everyday life. this study is a randomized controlled trial aimed at examining how ballet training influences knee movement-specifically knee flexion-during walking in children with idiopathic coxa antetorta. the goal is to determine whether ballet training enhances the children's overall mobility and how they feel about their ability to move. additionally, the study seeks to find out how this training can be effectively incorporated into the daily routines of affected schoolchildren.

Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic coxa antetorta with fna\> 30° * children between 8 and 12 years of age * cognitive abilities must include: ability to actively participate in a 60-minute ballet class; ability to communicate pain or discomfort; ability to attend training, testing and follow-up sessions. all included participants can make decisions on their own and do not show any signs of mental or cognitive limitations. exclusion criteria: * any surgery within 6 months prior to the start of the study or surgery scheduled during the study period. other medications can be continued as prescribed by the participants' physician * known cardiovascular or pulmonary diseases that have not received medical clearance to participate in the physical exercise intervention * neurological or other musculoskeletal comorbidities * the children should not have completed any ballet training in the last 12 months * pregnancy

Keywords: increased femoral anteversion (ifa) idiopathic coxa antetorta childhood knee pain physical activity intervention ballet training for children hip strength and mobility knee flexion in children exercise for hip flexibility in-toeing gait in children
evaluation of fast, same-day delivery of palliative radiotherapy without a planning ct (fast-mets)

Conditions: Metastasis

Summary: palliative radiotherapy is an effective treatment for patients with painful bone metastases. standard workflows often involve long waiting times or multiple visits. fast palliation completed during a single clinic visit can be achieved by omitting a planning ct scan, and using available diagnostic imaging for treatment planning. the adaptive treatment platforms provides the possibility to adapt positions differences between the diagnostic ct and radiotherapy treatment of the target and organs at risk. in this study, the investigators will investigate the experiences of patients who have been treated with this fast-adaptive workflow (fast-mets) using 2 questionnaires.

palliative radiotherapy is an effective treatment for patients with painful bone metastases, and currently the investigators have clinically implemented the fast-mets procedure at the department. all patients referred for palliative radiotherapy, in whom diagnostic imaging performed within 4 weeks is available, are eligible for this adaptive workflow. consultation by telephone is done beforehand to verify whether the complaints correspond to the location of the metastasis. this single-institutional, explorative study will investigate the experiences and quality of life of patients who were treated with this workflow. two study questionnaires are used, and informed consent will be obtained for both. the eq-5d-5l questionnaire will be completed on the day of treatment, after 6 weeks and 3 months post-treatment. the other questionnaire used was developed for patients treated with adaptive radiotherapy. two patients groups will be studied, namely those undergoing simple and complex palliative radiotherapy. patients treated with complex palliative radiotherapy are defined as those referred for re-irradiation to the site of metastasis, patients undergoing concurrent systemic therapy, and patients treated with a single fraction radiation dose exceeding 8 gy. in addition, the study will evaluate time spent on treatment preparation and delivery proces, and dosimetric aspects of the treatment.

Eligibility criteria:
inclusion criteria: * patients referred for palliative radiotherapy to metastases * recent diagnostic ct scan (preferably \<4 weeks) of the metastasis with full body contour of the patient included. exclusion criteria: * a solitairy metastasis from a primairy tumor with good a prognosis * a metastasis located in ventral ribs where respiratory motion of the target is expected * patients who are not fluent in dutch
tamoxifen in the prevention of breast cancer in hodgkin's disease survivors

Conditions: Hodgkin's Disease; Breast Cancer

Summary: the purpose of this study is determine whether or not tamoxifen reduces the chance of hodgkin's disease survivors developing breast cancer.

* patients will receive tamoxifen orally once daily to be taken at home for 1 year. they will be asked to complete a daily drug log to keep track of the pills taken or missed. * patients will also be asked to give a blood/dna sample which will be stored for possible further testing for the presence of cancer related genes that are known nor or discovered in the future. * patients will also receive a mammogram that will be reviewed by study officials. * side effects will be monitored every 2 months for one year, between visits to the clinic. * a follow-up visit will be conducted at the 6 month mark and includes a physical exam, blood work, health and wellness surveys) * a follow-up visit will be performed at the 1 year mark and includes a mammogram, gynecological exam, physical exam, blood work, health and wellness surveys. * patients active participation will be for 1 year. however, tamoxifen has been shown to be effective after a 5-year course in other women at increased risk for breast cancer, the patient may decide to stay on tamoxifen for 4 additional years.

Eligibility criteria:
inclusion criteria: * females diagnosed with hodgkin's disease at age \< 35 years * \> 5 years from mantle or chest radiation * current age \> 30 years * has completed childbearing * willingness to discontinue use of oral contraceptives or other hormonal contraception for duration of the study exclusion criteria: * history of secondary malignancy after hodgkin's disease, except thyroid cancer of basal cell cancer * recurrence of hodgkin's disease in the 5 years before study entry * current participation in any other cancer prevention study * current or prior use of tamoxifen * current use of coumadin * history of deep venous thrombosis, pulmonary embolism, or a condition known to be associated with hypercoagulability * history of cerebrovascular accident * history of macular degeneration * current use of chemotherapy for benign disease

Keywords: hodgkin's disease breast cancer prevention tamoxifen
pain relief during unsedated office hysteroscopy by applying tens

Conditions: Uterus Dysfunction

Summary: aim: to compare the pain-relieving effect of a specific application of tens vs. placebo tens and a control group during unsedated diagnostic office hysteroscopy. design: double-blind randomized placebo-controlled trial. setting: outpatient setting. population: women who attended annual gynecological check up, and were indicated for diagnostic office hysteroscopy.

nowadays, diagnostic hysteroscopy is an easy and economically acceptable technique, that is being used by the gynecologist to evaluate different pathologies that used to be studied by other blind techniques. although most women tolerate it well, the most common cause for failure during office hysteroscopy is pain. in order to overcome this adversity several studies have been carried out using different types of pain relievers as local anesthesia, misoprostol, music, and nsaid to prevent the occurrence of a vagal reaction, but the results have been contradictory. other analgesic alternatives that prioritize these three points should be considered. transcutaneous electrical nerve stimulation (tens) has become a very common electrotherapy as a pain-reliever because of its attributes, namely a noninvasive and non-pharmacological method based on the delivery of pulsed electrical currents through the skin, using surface electrodes, effective in many variety of conditions, such as neuropathic pain, musculoskeletal pain, headache, gynecological and obstetric pain, to treat both chronic and acute pain, even from visceral organs. aim: to compare the pain-relieving effect of a specific application of tens vs. placebo tens and a control group during unsedated diagnostic office hysteroscopy. design: double-blind randomized placebo-controlled trial. setting: outpatient setting; hospital provincial de castellon (spain) and hospital general de castellon (spain). population: women who attended annual gynecological check up, and were indicated for diagnostic office hysteroscopy

Eligibility criteria:
inclusion criteria: women who attended annual gynecological check up, and were indicated for diagnostic office hysteroscopy because of different pathologies such as: * postmenopausal endometrial thickening \>4mm; * postmenopausal abnormal uterine bleeding; * suspicious endometrial polyp or leiomyoma; * infertility study; * suspicious endometrial carcinoma; * hypermenorrhea exclusion criteria: * age less than 18; * previous cervical surgery; * neurological deficit; * chronic or preprocedural use of opioids or psychoactive drugs; * previous experience in tens; * cutaneous damage on the application sites; * pacemakers or automatic implanted cardiac defibrillators; * refusal to sign the informed consent form; * inability to understand informed consent form.

Keywords: outpatient hysteroscopy, tens
remote monitoring of covid-19 positive outpatients

Conditions: Covid19

Summary: this study seeks to evaluate how secondary data retrieved from remote physiological monitoring performed during routine outpatient/at-home care periods can allow for the discovery of novel physiomarkers that predict acute deterioration or hospitalization among people testing positive for coronavirus disease 2019 (covid-19).

most recent research publications and clinical trials have exclusively focused on the hospital and intensive care unit (icu) care of covid-19 patients. few have focused on how to direct care delivered at home, where the majority of coronavirus infected will recover, and how and when to rescue those who are at immediate risk for poor outcomes. to standardize the home monitoring process and offer guidance in this uncharted territory, the researchers have created a method for outpatient management of covid-19 patients and high suspicion influenza-like illness (ili) for emory university hospital. this includes the newly implemented model of clinics including in-person ambulatory management in the acute respiratory clinic (arc), the virtual outpatient management clinic (vomc), and the emory covid-19 outpatient remote monitoring registry (e-cormr). initial analysis of the management system, particularly in risk tier assignment, has shown that assigning risk tiers early can help to identify patients at risk for clinical deterioration. the researchers have also demonstrated symptom profiles and durations of the "typical" outpatient disease course. the e-cormr was used to create a dashboard for improved management of these frequently complex patients. it was determined after its creation that it could also be used for research purposes to store data collected from physiologic parameters. the goal of this study is to develop algorithms using secondary data abstracted from remote monitoring devices that were collected within the e-cormr. the researchers propose to derive robust algorithms through the analysis of that data that identify a potential hospitalization. the findings will not only improve the management of patients with known or suspected covid-19 but also provide information that allows early intervention on patients at risk of decompensation. this information can then be used by other healthcare systems to care for patients more safely at home, thus reducing the impact of covid-19 on overburdened acute care settings and preventing poor outcomes.

Eligibility criteria:
inclusion criteria: * identified to be positive for covid-19 by quantitative reverse transcription polymerase chain reaction (qrt-pcr) * demonstrate symptoms of covid-19 * symptom onset within 7 days * completed 21 days of remote monitoring with a medtronic remote pulse oximeter device exclusion criteria: * none

Keywords: telemedicine risk assessment
ketone supplementation in eating disorders

Conditions: Anorexia Nervosa; Bulimia Nervosa; Atypical Anorexia Nervosa; Atypical Bulimia Nervosa

Summary: this study will investigate the effects of ketone supplementation on eating behavior including drive to binge eat or restrict, mood and anxiety in individuals with anorexia or bulimia nervosa. in addition, the investigators will contrast the effects of active ketone supplementation versus placebo on electroencephalogram (eeg) measurement. all subjects enrolled in the study will undergo eeg on two consecutive days at the beginning of the study, after active ketone supplementation or placebo drink, matched in taste to the ketone drink. days will be randomized. thereafter, all subjects will take the ketone supplementation drink for two weeks, twice daily.

the goals of the study are: 1) to test the effect of bhb as a nutritional supplement for an and bn and 2) to test the ingestion of bhb on brain function. subjects will complete a battery of self-assessments and a diagnostic assessment in order to determine eligibility and for characterization of behavior to be used in later analyses. after eligibility is confirmed, subjects will complete 2 eeg scans on separate days after ingestion of ketone supplement drink or placebo and will complete a taste reward task during the eeg scan. subjects will then complete 2 weeks of daily ketone supplementation and self-assessments.

Eligibility criteria:
inclusion criteria: 1. must currently meet dsm-5 criteria for anorexia nervosa, bulimia nervosa, or osfed anorexia or bulimia nervosa based on the mini diagnostic interview 2. be medically stable as assessed by a comprehensive medical and behavioral evaluation conducted by a study physician 3. english as primary spoken language. 4. ability to respond to ema questions up to 6x per day within 60 minutes of receiving the message. exclusion criteria: 1. psychotic illness/other organic brain syndromes, dementia, somatization disorders or conversion disorders 2. current substance abuse or dependence in the past 3 months 3. physical conditions (e.g., diabetes mellitus, pregnancy) known to influence eating or weight 4. medical conditions associated with ketoacidosis: type 1 diabetes mellitus, acute pancreatitis, alcoholic gastritis, peptic ulcer disease, hepatitis or boerhaave syndrome (esophageal rupture) 5. history of significant head trauma 6. indication of intellectual disability or autism spectrum disorder 7. known allergy to any of the kenetikr drink components: d-beta-hydroxybutyric acid (d-bhb), stevia, monkfruit, potassium bicarbonate, sodium bicarbonate potassium sorbate or taste task solutions: sucrose, potassium chloride, sodium bicarbonate.
endothelial protection in convalescent covid-19 patients

Conditions: Endothelial Dysfunction; Inflammation; Thrombosis; COVID-19

Summary: this pilot open-label randomized controlled trial aims to assess if treatment with sulodexide may improve the endothelial status and inflammatory response in post-covid-19 patients. survived inpatients with severe-to-critical covid-19 within 14 days after discharge are randomized to receive sulodexide 250 lsu 1 oral capsule twice daily or no treatment for 8 weeks. biomarkers of endothelial dysfunction, inflammation, and prothrombotic changes are assessed at 0, 4, and 8 weeks. the hypothesis is that affected endothelial function, pro-inflammatory, and pro-thrombotic changes could be improved with sulodexide treatment in convalescent covid-19 patients who suffered a severe-to-critical clinical presentation and have chronic comorbidities of high risk for endothelial dysfunction.


Eligibility criteria:
inclusion criteria: * over 18 years old * male or female * documented pcr sars-cov-2 positive test * covid-19 convalescence (define as at least 10 days after the onset of symptoms, no fever for at least 24 hours without the use of antipyretics and improvement of respiratory symptoms) * informed consent signed * clinical severity presentation of 1. severe the disease is classified as severe if one of the following conditions is met: respiratory distress, respiratory rate ≥30/min oxygen saturation on room air at rest ≤93%. partial pressure of oxygen in arterial blood/fio2 ≤300 mm hg. or 2. critical if one of the following conditions is met. respiratory failure and mechanical ventilation are required. shock occurs another organ dysfunction is present * risk of health complication \>50% according to the health risk calculator * less than 14 days of hospital discharge. exclusion criteria: * concomitant use of another anticoagulant * known pregnancy * known hypersensitivity to sulodexide * need for hospital care at screening * renal insufficiency with crcl \<30ml/min or continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. * blood platelet count \< 30 000/µl * other conditions that are judged to carry an increased risk of bleeding as judged by the investigator * more than 30 days of clinical onset
comparison of biodegradable polymer vs durable-polymer in diabetic patients

Conditions: Percutaneous Coronary Intervention; Diabetes Mellitus

Summary: both biodegradable polymer-based biolimus-eluting stents (bp-bes) and durable polymer-based everolimus-eluting stents (dp-ees) have been shown to improve long-term clinical outcomes as compared with early generation des. bp-bes with dp-ees have been directly compared in 2 randomized trials, showing no differences between the two devices in all-comer patients during long-term follow-up. it is unknown whether these results are consistent in real-world patients with diabetes mellitus during long-term follow-up. to evaluate the safety and efficacy profile of biodegradable polymer-coated biolimus-eluting stents (bp-bes) as compared to durable polymer-coated everolimus-eluting stents (dp-ees) in patients with diabetes mellitus during long-term follow-up. consecutive diabetic patients undergoing percutaneous coronary interventions with bp-bes or dp-ees implantation were included in a multicenter registry between january 2007 and may 2012. long-term clinical outcomes between bp-bes and dp-ees will be compared using propensity score matching. the pre-specified primary endpoint is the occurrence of major cardiac adverse events (mace) - a composite of all-cause death, myocardial infarction (mi) or target-vessel revascularization (tvr). secondary endpoints are the individual components of the primary endpoint as well as definite stent thrombosis (st).


Eligibility criteria:
inclusion criteria: * age \> 18 years * diabetes mellitus * percutaneous coronary interventions with biolimus eluting stent or everolimus eluting stent implantation * signed informed consent exclusion criteria: * planned procedure requiring antiplatelet therapy withdrawal within 12 months from index coronary angioplasty * patients with contraindication to dual antiplatelet therapy (aspirin plus ticlopidine or clopidogrel) * known allergy to stent drugs