Kornimate/medical-research-clean huggingface dataset:
comparison between two coronally positioned flap with connective tissue

Conditions: Gingival Recession; Periodontal Atrophy

Summary: the aim of this study is to evaluate the effectiveness of total root coverage between two coronally positioned flap technique in miller recession class i and ii, in patients attending at "universidad el bosque" dental school clinics.

this is a blind, randomized controlled clinical trial.

Eligibility criteria:
inclusion criteria: * class i and ii miller recessions showing a recession depth ≥ 2 mm. * recessions isolated and / or maximum continuous two teeth. * recessions in incisors, canines and premolars * patients 20 to 60 years old. exclusion criteria: * systemic compromise, that contraindicates any periodontal surgical procedure. * warfarin medication. * uncontrolled diabetes mellitus with glycosylated hemoglobin ≥ 8 * chronic steroid therapy (dose of 7.5 mg/ day for more than 14 days) * hiv-aids infection with cd4 counts \<200. * immunosuppression. * recessions molars not be taken into account in the study. * patients who have used antibiotics one month prior to the surgical procedure. * pregnancy. * active smoker. * patients with a history of periodontal surgery at the recession area that has taken place in the last three months. * severe dental malposition, teeth rotation, versions teeth root coverage that contraindicates surgery. * non carious cervical lesions or caries where is not visible the cemento- enamel junction (cej). * active inflammation that contraindicates surgical procedure of the recession. * active orthodontics

Keywords: coronally positioned flap connective tissue gingival margin gingival recession/ treatment gingival recession/ surgery subepithelial connective tissue graft randomized controlled clinical trial surgical flaps treatment outcome
nutritional content of breast milk from mothers of premies

Conditions: Prematurity; Nutrition

Summary: the purpose of this study is to determine the correlation, if any, between the nutritional content of breast milk pumped by the mothers of very low birth weight (vlbw) infants in the neonatal intensive care unit (nicu) and the nutritional value they are actually receiving in a 24 hour period, since as a practical matter, these may not be the same.


Eligibility criteria:
inclusion criteria: * mothers of infants with a gestational age \<=30 weeks in the nicu who are supplying their own breast milk for use by their baby * reasonable likelihood of survival of infant to 28 days * infant on/ready for oral feeding by dol 7 days * willing to provide breast milk for their baby * able to produce at least 7ml breast milk per feeding * willing to abide by requirements of the study protocol * documentation of informed consent exclusion criteria: * unable to provide at least 7ml breast milk per feeding * medically unsuitable to provide breast milk to her baby * maternal age \<18 years of age

Keywords: prematurity nutrition breast feeding
application of large language models in emergency neurology

Conditions: Neurology; Emergency

Summary: emergency neurology covers a wide range of conditions, often involving urgent situations such as acute cerebrovascular diseases, seizures, central nervous system infections, and consciousness disorders. however, due to the time constraints in emergency care and limited patient information collection, misdiagnosis and missed diagnoses are common issues. large language models (llms) possess powerful natural language processing and knowledge reasoning capabilities, enabling them to directly handle and understand complex, unstructured medical data such as patient medical records, dialogue notes, and laboratory test results. llms show broad potential for application in complex medical scenarios. this study aims to evaluate the application value of llms in emergency neurology, specifically examining their diagnostic accuracy in emergency neurology conditions, analyzing the feasibility of treatment plans and further examination recommendations proposed by the model, and exploring their potential in improving diagnostic efficiency and aiding decision-making.


Eligibility criteria:
inclusion criteria: * age ≥18-80 years, male or female. * patients seeking emergency neurology care. * patients who can provide complete medical records (including consultation recordings, physical examination, test results, etc.). * voluntary participation and signing of informed consent. exclusion criteria: * patients who directly enter the resuscitation process due to the severity of their condition(e.g., patients who are immediately placed in the icu). * patients with unstable vital signs. * patients who are unable to communicate effectively (e.g., severe consciousness impairment or severe cognitive disorders). * patients who are currently participating in other clinical trials.
a cross-sectional natural history study to evaluate sweat volume and other phenotypic and genetic characteristics in patients affected by xlhed

Conditions: XLHED

Summary: the proposed natural history study will enroll male patients with a diagnosis of xlhed, female carriers of xlhed and healthy volunteers. the study protocol will include collection of xlhed questionnaires and clinical outcomes using minimally invasive technologies. data will be collected both retrospectively and prospectively. clinical outcome assessments will be performed at the nfed family conference on july 11-12, 2019. study participants will be able to complete xlhed questionnaires electronically ahead of the conference.


Eligibility criteria:
inclusion criteria: * informed consent * males with xlhed, female carriers of xlhed and healthy volunteers exclusion criteria: * treatment with an investigational study drug for xlhed * any major medical problems that would prevent her/him from participating in this study * known hypersensitivity to pilocarpine or pilocarpine-like muscarinic agonists (examples: urecholine, salagen, pilocar, and provocholine) * pacemaker

Keywords: natural history study x-linked hypohidrotic ectodermal dysplasia
natural orifice specimen extraction in low rectal cancer surgery

Conditions: Rectal Cancer; Surgery

Summary: this study aims to compare the postoperative outcomes of low rectal cancer patients who underwent surgery with natural orifice specimen extraction (nose) versus traditional pfannenstiel extraction.

natural orifice specimen extraction (nose) in colorectal surgery allows the extraction of the surgical specimen through the anal orifice. several studies demonstrated improved postoperative pain, bowel movements, patient-reported cosmetic satisfaction, and psychological wellbeing after nose compared with traditional pfannenstiel extraction. however, most of these studies focused on colon surgery. the aim of this retrospective propensity score matched study is to investigate the postoperative outcomes of nose in low rectal cancer surgery, classified according to the english national low rectal cancer development programme (lorec).

Eligibility criteria:
inclusion criteria: * patients undergoing low anterior resection with total mesorectal excision (tme) for low rectal cancer between january 2017 and january 2023 * patients with rectal cancer classified as "low" according to the english national low rectal cancer development programme (lorec) exclusion criteria: * patients undergoing non-restorative procedures * patients undergoing immediate or delayed handsewn coloanal anastomosis * patients undergoing planned open surgery or unplanned conversion from minimally invasive to open surgery * patients with a concomitant diagnosis of inflammatory bowel disease (ibd)

Keywords: rectal cancer natural orifice specimen extraction propensity score matched
designing visual tools to enhance cancer surgeon decision-making

Conditions: Prostate Cancer; Kidney Cancer

Summary: this prospective study will compare pre-post pilot test of surgeon-facing, visual decision support among urologists seeing patients with newly diagnosed localized prostate and kidney cancer. up to 20 urologists (10 academic and 10 community) will be enrolled. the goal will be to capture up to 10 pre- and 10 post-intervention patient encounters for each urologist with an accrual target of 200 unique patient visits (100 pre and 100 post-intervention) over a half-year period. patient encounters pre- and post-intervention will be audio recorded, transcribed, and coded for discussion of risks/benefits of surgery and strength of recommendation. patients and urologists will complete additional surveys on their perceptions of patient-provider communication. urologists will further describe their experience and rate their satisfaction with visual decision support. communication (content and perceived) will be compared pre- and post-intervention with secondary comparisons by race and care setting. it was hypothesized that the discussion of risks and benefits of cancer surgery will increase post-intervention and that the strength of recommendation and perceptions of patient-provider communication will change. the secondary hypothesis is that these changes will differ by patient race and care setting.


Eligibility criteria:
inclusion criteria: in order to participate in this study, a subject must meet all of the eligibility criteria outlined below. * verbal informed consent was obtained to participate in the study. * subject is willing and able to comply with study procedures based on the judgment of the investigator or protocol designee. * age ≥ 18 years at the time of consent. * for patient subjects, hipaa authorization for the release of personal health information and a new histologic diagnosis of localized prostate cancer based on prostate biopsy or clinical diagnosis of t1 renal mass (≤7 cm in diameter) suspicion for kidney cancer based on cross-sectional imaging. new diagnosis is defined as within 6 months of consent. t1 renal masses include solid masses or bosniak iii/iv cystic masses. * for physician subjects, practicing urologist in north carolina at unc health, novant health, or an affiliated site and sees patients with suspected or confirmed prostate or kidney cancer. exclusion criteria: the subjects meeting the following criteria will be excluded from study participation: * non-english speaking. * unwilling or unable to complete informed consent. * for patient subjects: 1. has staging information indicating locally advanced or metastatic disease. this would include psa \>50 ng/ml, imaging suggestive of distant metastasis, or lymph node involvement, renal masses \>7 cm or invading in renal sinus or tumor thrombus. 2. histologic or clinical diagnosis \>6 months before date of consent.
dispatcher-assisted cpr: low-dose, high-frequency simulation-based training

Conditions: Out-Of-Hospital Cardiac Arrest

Summary: clear, concise, yes, and no answers can be challenging to achieve in the assessment of consciousness and breathing in out-of-hospital cardiac arrest (ohca) calls. often callers will provide an unclear response, and this can lead to hesitation on the part of the emergency medical dispatcher (emd). further, the relatively small proportion ohca calls represent might demand the need for simulation training in the dispatcher-assisted cardiopulmonary resuscitation (da-cpr) guiding itself. therefore, the investigators investigate whether low-dose, high-frequency (ldhf) simulation-based training of emds can increase the quality of da-cpr in a simulation setting. additionally, the investigators measure whether the effect of the training will be transferred to real ohca calls. the study is a randomised controlled trial comparing ldhf simulation-based training to standard quality improvement of the emd in a single centre. the study protocol is structured according to the spirit 2013 statement, and the study will be reported in compliance with the consort 2010 statement. the investigators chose emds receiving standard quality improvement as the comparator group, to reflect a representative cohort of the emds not exposed to the ldhf simulation-based training program. the aims of this study are: 1. to measure the effect of ldhf simulation-based training on the quality of da-cpr in a simulation setting. 2. to measure the effect of ldhf simulation-based training on the quality of da-cpr in real ohca calls. the investigators hypothesise that ldhf simulation-based training will increase the quality of da-cpr in the intervention group in a simulation setting and that this improvement is transferred to real ohca calls - although the effect in real ohca calls might be smaller due to the complexity of some calls. the investigators hypothesise that this improvement can be detected as a decrease in time to first bystander compression (ttfc), an increase in clarification of consciousness and breathing without asking additional questions, a decrease in time to recognition of cardiac arrest, and an increase in calls where the emd provide da-cpr instructions on patients in cardiac arrest.


Eligibility criteria:
inclusion criteria: - emd employed at the copenhagen ems at the time of enrolment. exclusion criteria: * mean working time as call taker at copenhagen ems \< 8 hours/week. * planned employment cessation at the copenhagen ems during the data collection period. * planned leave from work longer than four weeks during the data collection period. * starting employment at the copenhagen ems during the study period.
dna/rna analysis of blood and skeletal muscle in patients undergoing cardiac resynchronization therapy (crt)

Conditions: Cardiomyopathy (Ischemic or Non-Ischemic)

Summary: genes expressing inflammatory cytokines (tnf- alpha, il1 etc) and genes involved in apoptosis (caspase 3, bax, bcl-2, fas) are dysregulated in the skeletal muscles of the patients who have muscle wasting and decreased exercise capacity with chf. patients who show benefit from crt may also show reversal of the inflammatory/apoptotic cascade that accompanies chf and these patients may be the ones who benefit the most from crt

1. the general objective of this study is to: 1. to identify the molecular pathways that may be altered in the blood and skeletal muscles of the patients undergoing crt by using transcriptional analysis of the blood and skeletal muscle in these patients 2. to identify objective measurable molecular signals, using gene expression profiling, that correlate with clinical improvement in patients undergoing crt. 3. to identify the molecular profile of patients who are most likely to benefit from crt with improvement of exercise capacity and reversal of cardiac cachexia. 4. to identify biochemical pathways involved in cardiac cachexia. 5. to identify genes involved in positive remodeling and reversal of apoptotic cascade in the skeletal muscle.

Eligibility criteria:
inclusion criteria: * patients with poor lv function and an ef of ≤35% * patients who are symptomatic with class ii or class iii heart failure on optimal medical therapy. * patients with ekg showing qrs duration of greater than 120 ms and meet criteria for bi-ventricular icd implantation. exclusion criteria: * patients with other co-morbid conditions which could contribute to cachexia, such as end stage renal disease, ongoing malignancy, chronic or acute liver failure, age greater than 80yrs. * patients who are unable to walk and are wheelchair bound or need assistance to walk for reasons other than chf. * patients with muscular dystrophies and myopathies. * patients with untreated hyper or hypothyroidism. * patients on dialysis. * patients with recent (\<12 weeks) revascularization. * patients with recent (\<12 weeks) myocardial infarction.
virtual testis cancer lay support and survivorship aim 2

Conditions: Testicular Cancer; Testis Cancer

Summary: this study examines how virtual support can enhance well-being and survivorship in men with testicular cancer. participants in north carolina will be randomized into two groups: one with access to a virtual support platform and the other with access to patient educational materials only. after six months, the emotional well-being, self-efficacy, financial toxicity, and quality of life of both groups will be compared at 3 months and 6 months after baseline assessments.


Eligibility criteria:
inclusion criteria: * men within 5 years of their initial diagnosis of germ cell testicular cancer. * the subject is willing and able to comply with study procedures based on the judgment of the investigator. * adults aged 18-95 years old. * electronic informed consent was obtained to participate in the study. exclusion criteria: * woman gender * non-english speaking * unwilling or unable to complete informed consent. * on active treatment for another cancer. * actively receiving chemotherapy, radiation, or surgery for testicular cancer.

Keywords: virtual support emotional well-being self-efficacy financial toxicity quality of life
hernias reparation after kidney transplantation study

Conditions: Prosthesis User; Renal Transplantation

Summary: correlation between hernias reparation in patients who have received a kidney transplant. the investigators will analyze the data of patients who have been treated for reparation of incisional hernia after kidney transplantation with or without the placement of a prosthesis.

in the scientific literature, the percentage of post incisional hernia in kidney transplanted patients is very variable, and not too well-argued, especially in the context of prevention and individuation of risk factors. the increase of surgical management of hernias reparation in renal transplant patients justifies the start of a mon-centric type study. the investigators will look for risk factors with a retrospective, observational study, by analyzing the type of surgical repair of their post-surgical wall defect. the analysis of costs/benefits on postoperative, intraoperative, or preoperative prevention will be taken into account.

Eligibility criteria:
inclusion criteria: - hernia post renal transplantation exclusion criteria: - underage

Keywords: renal transplantation post incision hernia
the relationships between personal identity, autobiographical memory and future thinking in people with multiple sclerosis

Conditions: Multiple Sclerosis, Relapsing-Remitting; Healthy Controls

Summary: personal identity is composed of multiple facets of the self that are constructed and nourished through memories of past experiences (i.e., autobiographical memory) and the imagination of events that may occur in the future (i.e., future thinking) . while our previous work has shown that people with relapsing-remitting multiple sclerosis (pwrrms) have autobiographical memory and future thought disorders, their impact on personal identity has not yet been explored. based on a cognitive and clinical neuropsychology approach, this research project aims to better understand the cognitive mechanisms involved in the relationship between identity, autobiographical memory and future thinking in pwrrms. we will examine the extent to which pwrrms manage to maintain and reshape their identity through life experiences, with a particular interest in the potential integration of the disease as a facet of their identity. in addition, we will explore the positive and/or negative consequences of disease-related identity changes on emotional well-being and quality of life, as well as their links with the duration and severity of the disease. overall, this research project will contribute to identify new therapeutic levers that can be used for the development of adapted and personalized care.


Eligibility criteria:
for the clinical group: inclusion criteria: * diagnosis of relapsing-remitting ms according to the mcdonald's revised diagnostic criteria * people aged between 18 and 55 * french native speaker * access to a computer or tablet, equipped with internet access, a camera and a microphone non-inclusion criteria: * ms relapse in the month prior to the inclusion * treatment with corticosteroids during the month preceding the inclusion * form of ms other than the relapsing-remitting form * neurological history (other than ms for patients), history or current presence of psychiatric disorders (e.g., depression, anxiety disorders, schizophrenia), substance abuse (e.g., alcohol, cannabis; past or present) * other diagnosed chronic pathology(ies) (other than ms for patients) * severe cognitive impairment * persons mentioned in articles l1121-6 to l1121-8 in the french law (minors, persons deprived of liberty, adults subject to protective measures) for the control group: inclusion criteria: * people aged between 18 and 55 * matched in age, gender and level in education * french native speaker * access to a computer or tablet, equipped with internet access, a camera and a microphone non-inclusion criteria: * neurological history (other than ms for patients), history or current presence of psychiatric disorders (e.g., depression, anxiety disorders, schizophrenia), substance abuse (e.g., alcohol, cannabis; past or present) * other diagnosed chronic pathology(ies) (other than ms for patients) * severe cognitive impairment * persons mentioned in articles l1121-6 to l1121-8 in the french law (minors, persons deprived of liberty, adults subject to protective measures)
a prospective randomized double-blind trial comparing 3 doses of intravenous ketorolac for pain management

Conditions: Pain

Summary: hypothesis: intravenous administration of ketorolac in a dose of 10 mg is as effective in treating severe acute pain in patients presenting to the ed as 15 mg and 30 mg.

ketorolac tromethamine is a non-steroidal anti-inflammatory drug (nsaid) that is widely used in the emergency department (ed) for the treatment of moderate-to-severe pain. ketorolac is available in both oral and parenteral forms and possess significant analgesic potency. however, ketorolac provides few advantages over other currently available analgesics and its use is limited by a virtue of having an "analgesic ceiling" with the dose being 10mg as well as having a range of severe side effects, of which gastrointestinal hemorrhage is most concerning.the concept of an analgesic ceiling is that doses beyond this value (10mg) do not provide additional analgesia and do contribute to side effects. in spite of this, the majority of research conducted on ketorolac in the ed and recommendations in tintinalli's emergency medicine textbook advocating for use of three-to-six fold higher dosages. hypothesis: intravenous administration of ketorolac in a dose of 10 mg is as effective in treating severe acute pain in patients presenting to the ed as 15 mg and 30 mg.

Eligibility criteria:
inclusion criteria: severe flank and abdominal pain, severe musculoskeletal pain (traumatic and non-traumatic in origin), headache, dental pain. exclusion criteria: age \>65, active peptic ulcer disease, acute gastrointestinal hemorrhage, known hx of renal or hepatic insufficiency, hx of allergies to nsaids.