Kornimate/medical-research-clean huggingface dataset:
eculinary medicine emphasizing herbs/spices to increase vegetable intake

Conditions: Hypertension; Diet, Healthy; Culinary Medicine

Summary: e-culinary medicine emphasizes on herbs and spices, will increase consumption of vegetables and reduce sodium in the diets of people with hypertension and lead to a more favorable health profile.

this will be a randomized controlled intervention in collaboration with physician care clinics. participants with hypertension will be assigned to an eculinary medicine group (e-group) or control that will receive recipes without the eculinary intervention (c-group). the intervention group will receive weekly cooking demonstration videos, a one-time nutrition education session based on the content of the nutrition care manual from the academy of nutrition and dietetics, a bi-weekly phone visit, and will be given a digital blood pressure monitor and a digital weight scale. the cooking demonstrations will focus on utilizing herbs and spices in the preparation of various vegetables using different cooking methods aimed to reduce sodium and increase vegetable consumption. the control group will receive only recipes from the eculinary intervention as well digital blood pressure monitor and a digital weight scale.

Eligibility criteria:
inclusion criteria: * clinical diagnosis hypertension * age above 18 exclusion criteria: * use of tobacco * self-reported history of chronic diseases other than hypertension * allergy to any food * pregnant or lactating * alcohol or drug dependence
a cohort study on biomarkers of hypertension in guangdong province(gdp study)

Conditions: Hypertension; Cardiovascular Diseases

Summary: hypertension is the most common chronic diseases and a most important risk factor for cardiovascular and cerebrovascular diseases, and also a substantial public health problem. the purpose of the study is to investigate the association between biomarkers and adverse outcomes in patients with hypertension.

study population includes subjects who are hypertension, of any race or ethnicity, 18 or older years of age, and have provided written informed consent to provide whole blood specimens at one or more study visits. physical examination, questionnaire survey and biological sample collection will be conducted at baseline and the incidence of all-cause and cardiovascular mortality will be investigated during follow-up.

Eligibility criteria:
inclusion criteria: * ≥18 years old * in accordance with the diagnosis of hypertension (including blood pressure ≥140/90mmhg and/or taking antihypertensive drugs and/or self-reported hypertension) exclusion criteria: * \<18 years old * unsigned informed consent * pregnant women and lactation

Keywords: hypertension cardiovascular diseases mortality biomarker
yoga for patients with chronic back pain and poor prognosis

Conditions: Low Back Pain; Chronic Low-back Pain; Back Pain; Back Pain Lower Back Chronic

Summary: the goal of this clinical trial is to investigate the effectiveness of yoga for patients with chronic low back pain and high risk of poor prognosis. the main question it aims to answer is: - in patients with back pain and high risk of poor prognosis, what is the effectiveness of yoga plus education on reducing pain and disability compared to a control group receiving education alone? a total of 110 patients with chronic low back pain and classified as high risk of poor prognosis according to the orebro musculoskeletal pain screening questionnaire (i.e. score ≥ 50 points out of 100) will be recruited for this study. participants will be randomized into two groups: yoga and control. the yoga group will receive a 3-month course of yoga program consisting of two sessions per week and 3 educational classes. the control group will receive 3 educational classes over a 12-week period. outcome measures will be assessed at baseline, at post-intervention (i.e. 3-months post randomization) and at 6-month follow up (i.e. 6-months post randomization).


Eligibility criteria:
inclusion criteria: * report chronic nonspecific lbp, defined as pain and discomfort localized below the costal margin and above the inferior gluteal folds, with or without leg pain and of at least 3 months' duration. * score ≥ 50 points (out of 100) in the orebro musculoskeletal pain questionnaire. * have an average back pain intensity of 3 points or more on a 0-10 numerical pain rating scale. exclusion criteria: * serious spine pathology (e.g. tumors, fractures, and inflammatory diseases). * nerve root compromise (i.e. at least 2 of the following signs: weakness, reflex change, or sensation loss associated with the same spinal nerve). * previos spinal surgery. * pregnancy or having given birth within the previous 3 months. * any medical condition that prevented being physically active (e.g., serious cardiovascular, kidney or neurological diseases). * any other musculoskeletal condition that may affect activity and movement participation in a yoga program during the last year. * not currently receiving other physical activity-based intervention (e.g., pilates, physical therapy, aquatic exercise). * inadequate portuguese literacy for the study's questionnaires and instructions.

Keywords: low back pain chronic low back pain yoga poor prognosis
effect of oral pregabalin on hyperalgesia and post-operative pain in patients undergoing nephrectomy surgery: sex differential study

Conditions: Living Kidney Donors Undergoing VAMS-nephrectomy

Summary: hyperalgesia is known to be caused by the excitatory amino acid through nmda receptor. gaba, an inhibitory amino acid, alters the opioid receptor sensitivity against pain resulting hyperalgesia. if the gaba level can be maintained at certain level, the progression into hyperalgesia can be averted. gaba related drugs are known to decrease the postoperative opioid consumption, lower the degree of pain, and prevent hyperalgesia. we hypothesize the effective postoperative pain management and the prevention of hyperalgesia from pregabalin, gaba analogue, and the possible sex difference in such effects of pregabalin.


Eligibility criteria:
inclusion criteria: * 18, \<51 years * healthy patients accepted for video-assisted living donor nephrectomy exclusion criteria: * female patients who are pregnant or menopause * patients undergoing hormonal therapy * patients having neurologic disease or already taking gaba related drugs (pregabalin, gabapentin), or taking opioid drugs * insulin resistant diabetes * renal deficiency (egfr \< 60 ml/min/1.73 m2) * emergency operation, hemodynamically unstable patients * foreigner * allergic to medication given in this study
endometriosis group care

Conditions: Endometriosis; Pelvic Pain

Summary: the goal of this clinical trial is to test the effectiveness of the peer empowered endometriosis pain support (peeps) program in people living with endometriosis-related pelvic pain. the main question\[s\] it aims to answer are: * is peeps effective at decreasing pain interference and improving patient-reported quality of life outcomes? * what are the barriers and facilitators to peeps implementation? participants will engage in eight weekly 2-hour sessions led by an endometriosis specialist, pain psychologist, pelvic floor physical therapist, and yoga instructor. at these sessions they will participate in peer support, education, mindfulness, and yoga.

this is an 8 week interdisciplinary, integrative group care program conducted through the department of obstetrics and gynecology (ob/gyn) at washington university in st. louis (wustl). the program, called peeps, incorporates mindfulness, physical therapy, yoga, physical activity, nutrition, and education. additionally, peeps will provide peer support and demonstrate investment of individual clinicians and the healthcare system. the program focuses on equipping participants with pain management and coping skills so they have an expanded toolkit to manage their pain after completing the program.

Eligibility criteria:
inclusion criteria: * age 18-48 years * operative confirmation of endometriosis * chronic pelvic pain (defined as pain perceived to originate from the pelvis, lasting ≥6 months) * no plan to have surgery in next 12 weeks * be able to attend eight 2-hour weekly sessions on the washington university campus exclusion criteria: * non-english speaking * currently pregnant * severe physical impairment * history of hip or spine surgery * opioid use ≥ 5 days in the past 3 months, other than for the 6-week post-operative period * current or history of psychiatric disorder with psychosis * vulvadynia or vaginismus

Keywords: group care integrative care pelvic floor physical therapy yoga mindfulness patient-centered outcomes
r-verapamil for the prophylaxis of episodic cluster headache

Conditions: Episodic Cluster Headache

Summary: this is a double-blinded, randomized, parallel, placebo-controlled phase 2 study to evaluate the safety and efficacy of r-verapamil in the prophylaxis of episodic cluster headache.

approximately 30 subjects (about 15 per treatment group),will be enrolled and randomized to receive either r-verapamil or placebo for 2 weeks. the study will consist of a 1-week run-in period and a 2-week treatment period (r-verapamil or placebo). the total duration of the study for each treatment group is 3 weeks.

Eligibility criteria:
inclusion criteria: * healthy man or woman between the ages of 18 and 65 * in good health as determined by medical history and medical examination * has a diagnosis of episodic cluster headache as defined by the international classification of headache disorders (2nd edition) * has a lifetime prevalence of at least 2 prior cluster bouts - subjects must experience at least 7 attacks/week during the run-in baseline period * subjects must have a typical cluster period lasting at least 1 month. subjects must be present in active cluster period and the expected remaining duration of the cluster cycle must be at least 3 weeks from baseline day 1 visit * able to differentiate other headache types from cluster headaches * is using or agrees to use a medically acceptable form of contraception(female of child-bearing potential) * negative urine pregnancy test prior to study entry(female of child-bearing potential) * concomitant medication that, in the opinion of the investigator and the patient's general practitioner(gp), do not pose an unacceptable risk based upon the prescribing information for verapamil * able to understand and comply with all study requirements * written informed consent exclusion criteria: * women who are pregnant or lactating * subjects who, in the investigators opinion, have a history or have evidence of a medical or psychiatric condition that would expose them to an increased risk of a significant adverse event or would interfere with the assessments of efficacy and tolerability * use of any drug or having any medical condition which might interact adversely with, or interfere with the action of, the study medication * the concomitant use of beta blockers * the consumption of grapefruit juice * allergic to or has shown hypersensitivity to verapamil or agents similar to verapamil * abuses opioids or has a history of significant drug or alcohol abuse within the past year as determined by investigator * has participated in an investigational drug trial in the 30 days prior to the screening visit * has liver or kidney disease * has a cardiopathology contraindicating verapamil administration * subjects with previous adynamic ileus. * subjects with chronic cluster headache * use of antipsychotic, antidepressants, lithium or other prophylactic treatment less than one month prior to inclusion
isometric intervention for lateral elbow tendinopathy

Conditions: Lateral Elbow Tendinopathy; Elbow Pain; Elbows Tendonitis; Elbow Sprain; Elbow Injury

Summary: this study will be looking at people with lateral elbow tendinopathy (elbow pain). the goal is to determine if a one-time isometric intervention will positively change the level of pain and strength as compared to baseline measurements. after determining baseline strength and pain level, an intervention consisting of several trials of isometric hand/wrist contractions will be performed by the participant. pain and strength will again be assessed immediately after the intervention.

participants will be randomized into two different groups in 10 participant blocks, meaning after every 10 participants eligible and completing the study, there will be 5 participants assigned to each group. group 1 will complete a protocol with 10 sets of 10 second isometric holds followed by 10 second rest intervals between sets. each repetition will be performed as closely to the targeted 30%-40% value. group 2 will complete a protocol with 5 sets of 20 second isometric holds followed by 20 second rest intervals between sets. each repetition will be performed as closely to the targeted 30% value. resistance for both testing conditions will be performed against the examiner's external resistance/against the microfet hand held dynamometer. immediately after the intervention, all participants will again repeat their maximal grip on their affected arm using the jamar hand held dynamometer and will grade their pain level. (the protocol will be identical to the pre testing procedure from above). the pain score and force output will be obtained and documented. once these steps are complete, testing will cease. all participants will be instructed to follow their referring provider's treatment intervention.

Eligibility criteria:
inclusion criteria: * - 18 years old or older * currently has lateral elbow pain * if bilateral lateral elbow pain is present, the more symptomatic side will be assessed * at the time of presentation, individuals have been evaluated as having clinical diagnosed let for at least 4 weeks * and: positive pain response to at least two of the following tests: * pain with palpation on the affected elbow * pain with resisted wrist or middle finger extension * pain while stretching the lateral forearm muscles (mills test) * at least 30% deficit of pain-free grip compared with the unaffected side exclusion criteria: * - radicular/cervical conditions reproducing elbow symptoms * rheumatoid arthritis * other elbow pathologies: bursitis, medial epicondylalgia, radial nerve entrapment, posterolateral rotary instability * history of fracture to the radius, ulna, or humerus with resultant deformity of the involved extremity * history of an injection within 6 months * inability to place the shoulder, elbow and wrist in the required testing position * the affected elbow had been operated on
ischemic heart disease incidence and indices of body-fat distribution

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Ischemia; Obesity

Summary: to determine the association between ischemic heart disease incidence and anthropometric indices of body-fat distribution.

background: previous studies have demonstrated that abdominal obesity can be predictive of ischemic heart disease. these prospective cohort studies employed simple indices of body-fat distribution such as waist-to-hip circumference ratio or subscapular skinfold. their similar results suggested that increased abdominal obesity conferred a two-fold increased risk of ischemic heart disease among middle-aged men. the two proposed studies permitted testing of alternative fat-distribution indices which might be stronger risk factors for ischemic heart disease incidence than the waist-to-hip-ratio or the subscapular skinfold. design narrative: two parallel case-control studies were conducted. in both studies, subjects were measured for girth, skinfold, abdominal sagittal diameter, height, and weight. analyses for both protocols considered men and women separately. possible confounders of the association between fat-distribution indices and ischemic heart disease were considered and if required, adjusted for in multivariate analyses. possible confounders included race, age, tobacco use, alcohol use, diabetes, social class, hypertension, cholesterol levels, and physical activity levels. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
the superiority of contralateral oblique view for mid-thoracic epidural assess

Conditions: Herpes Zoster; Postherpetic Neuralgia; Cancer

Summary: the aim of the present study is to compare contralateral oblique view with the lateral view for fluoroscopic guided mid-thoracic epidural assess.

a thoracic epidural assess (block or catheter insertion) is a widely used intervention to reduce pain in patients with postherpetic neuralgia or who underwent chest and upper abdominal surgery. in order to achieve the correct procedure, accurate access to the thoracic epidural space is needed. however, a thoracic epidural assess is a relatively more difficult procedure than procedures used in other regions, because the spinous process of the thoracic vertebra is longer than that of the lumbar vertebra, and the area through which the needle can approach the epidural space is relatively smaller due to an acute angle and larger distance between the skin and the epidural space. the midthoracic region (t4-8) is the most difficult area when performing this procedure. to overcome this issue, a method of approaching the thoracic epidural space through the contralateral oblique view (clo view) has been introduced, however, unlike the cervical or lumbar spine, advantages of the clo view over the lateral view or the optimal angle of the clo view have not yet been studied. therefore, we planned this study to investigate the advantages of the clo view compared with the lateral view and to determine the optimal angles of the clo view when fluoroscopic guided mid-thoracic epidural assess.

Eligibility criteria:
inclusion criteria: * scheduled for mid thoracic (t4-t8) epidural block or catheter insertion * 20 ≤ age \<80 * presence of thoracic mri or ct * when obtaining informed consent voluntarily exclusion criteria: * allergy to local anesthetics and contrast dye, and steroid * use of anticoagulants or antiplatelet medication, coagulopathy * infection at the insertion site * neurological or psychiatric disorders * prior spine instrumentation * pregnancy

Keywords: fluoroscopy contralateral oblique view thoracic epidural block mid thoracic epidural space
active reference (fluoxetine) fixed-dose study of vortioxetine in paediatric participants aged 7 to 11 years with major depressive disorder (mdd)

Conditions: Depressive Disorder, Major

Summary: investigation of the efficacy and safety of a new potential treatment of major depressive disorder (mdd) in paediatric participants (age 7 to 11 years).


Eligibility criteria:
inclusion criteria: 1. the participant has mdd, diagnosed according to diagnostic and statistical manual of mental disorders, 5th edition (dsm-5™). 2. the participant has a cdrs-r total score ≥45 at the screening visit and the baseline. 3. the participant has a cgi-s score ≥4 at the screening visit and the baseline. 4. the participant is a boy or girl, aged ≥7 and \<12 years at screening visit 5. the participant has provided assent to participation and parent(s)/legal representative (s) signed the informed consent form. exclusion criteria: 1. the participant has participated in a clinical study \<30 days prior to the screening visit. 2. the participant has previously participated in a study with vortioxetine. other protocol defined inclusion and exclusion criteria may apply

Keywords: paediatric
effect of artificial tears on the parameters of the eye and its impact on iol power calculation for cataract surgery

Conditions: Cataract Senile; Dry Eye

Summary: first, preoperative biometry of the eye at the iol master® will be performed. then, corneal topography will be measured at the oculus pentacam®. afterwards, one of two eye drops are instilled in the eye, and biometry and corneal topography will be repeated after 5 minutes. for all patients, the barrett universal ii formula will be used for calculation of iol power. predicted refraction outcome will be referred to as seq. the chief surgeon will perform the uneventful standard cataract operation with in-the-bag implantation of a hoya iol (model 251) through a 2.4-mm corneal incision. a subjective refraction using plus principle will be performed one month after the operation, and etdrs visual acuity charts will be used to measure best-corrected visual acuity. refraction will be described as sr (postoperative seq) and will be calculated as: sr = sphere + (0.5\*cylinder)

first, preoperative biometry of the eye at the iol master® will be performed. then, corneal topography will be measured at the oculus pentacam®. patients will be classified as dry eye or normal eye based on but. the tear film breakup (but) time of less than 5 seconds will be diagnosed as dry eyes.afterwards, one of two eye drops are instilled in the eye, and biometry and corneal topography will be repeated after 5 minutes. for all patients, the barrett universal ii formula will be used for calculation of iol power. predicted refraction outcome will be referred to as seq. the chief surgeon will perform the uneventful standard cataract operation with in-the-bag implantation of a hoya iol (model 251) through a 2.4-mm corneal incision. a subjective refraction using plus principle will be performed one month after the operation, and etdrs visual acuity charts will be used to measure best-corrected visual acuity. refraction will be described as sr (postoperative seq) and will be calculated as: sr = sphere + (0.5\*cylinder)

Eligibility criteria:
inclusion criteria: * a patient diagnosed with age related cataract * 30 to 95 years old * medical history and physical examination should be normal. exclusion criteria: * • abnormality of the cornea (scaring of the cornea) * if any topical therapy (i.e. glaucoma) of the eye is needed * active allergy of eye or nose * any conjunctivitis or keratitis * if nasolacrimal drainage apparatus is abnormal * severity level 4 of dry eye (constant discomfort in the eye accompanied with visual symptoms, filamentary keratitis, , keratinization, severe conjunctival injection, ulceration clumping of mucus glands, tear debris, , trichiasis, symblepharon) * deformities of lid * preceding eye trauma or surgery * any uncontrolled ocular disease or systemic disease * lactation * pregnancy
clinical study of eplerenone in japanese patients with chronic heart failure

Conditions: Heart Failure

Summary: a study to compare the efficacy and safety of eplerenone in japanese chronic heart failure patients with placebo.

the aim of this study was to show consistency with the emphasis-hf trial (nct00232180), which was defined as a hr of the primary endpoint of below 1.

Eligibility criteria:
inclusion criteria: * japanese chronic systolic heart failure patients with lvef =\<30% by echocardiography and nyha ii or more * patients who receive standard therapy (angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blocker or diuretic) exclusion criteria: * patients with a myocardial infarction, stroke, cardiac surgery or percutaneous coronary intervention within 30 days prior to randomization. * patients with serum potassium \>5.0 mmol/l or egfr \<30 ml/min/1.73 m2.

Keywords: double-blind eplerenone japanese