Kornimate/medical-research-clean huggingface dataset:
role of us vs x ray in detection of pediatric elbow fractures.

Conditions: Elbow Fractures

Summary: the purpose of this prospective study is to evaluate and compare the accuracy of elbow ultrasonography with x ray radiography for the diagnosis of elbow fractures in children following trauma in order to detect the validity of us in diagnosis of fractures as a dependent tool.

acute bone fractures in children are common and account for 10-25% of total injuries in early ages with considerable effects on activity restriction and subsequent high socioeconomical impact. in these cases, the elbow is a common site of pediatric fractures (account for up to 15% of all fractures) referring to the emergency department, and diagnostic testing with x-ray, including standard 2-way anteroposterior and lateral views, are required primarily for the evaluation of elbow injuries. in the setting of elbow trauma, the posterior fat pad sign on lateral radiographs is highly sensitive for fracture . however, radiological assessment of the elbow may be challenging in early ages due to the non-ossifed epiphysis and often non-exact two- plane radiographs in uncooperative children. because of the higher sensitivity of growing bones to ionizing radiation, and dose-dependent radiation exposure is both ct scans and x-ray, every imaging should be minimized in children. therefore, alternative imaging methods, such as us, have become a current issue to reduce exposure to radiation . ultrasound is radiation-free, it is a real-time bedside assessment, it can be immediately performed and is easily accessible, and it is fast and reliable ,ultrasonography can detect cortical disruption and irregularity, which directly indicates fractures. however, an elevated posterior fat pad can be easily identified by us, indirectly indicates intracapsular fractures . ultrasonography is superior to radiography in detecting posterior fat pad elevation. elbow joint effusion is a classic finding after trauma. it is not always associated with a cortical fracture, whereas lipohaemarthrosis, corresponding to the presence of blood and lipid material in the posterior fat pad, indicates an intraarticular elbow fracture, too. lipohemarthrosis, as well as an elevated posterior fat pad, can easily be identifed on ultrasound.

Eligibility criteria:
inclusion criteria: * the patients' age between 7 month and 14 years with a suspected elbow fracture. * patients who less than 7 days after the injury of elbow. exclusion criteria: * patients with a an open injury in elbow. * patients with suspected vascular injury. * patients with unstable vital signs .
microwave ablation of breast tumors

Conditions: Breast Cancer

Summary: the purpose of this protocol is to pathologically evaluate the amount of destruction of cancer cells by microwave ablation (mwa) in primary breast tumors.

minimally invasive surgical alternatives are becoming more attractive for the treatment of malignancy due to improvements in technology, reduced costs and reduced morbidity. the main objective of this protocol is to determine the extent of ablation based on time and power parameters of the medwaves in breast cancers. this would be accomplished in patients diagnosed with breast cancer who are already scheduled for breast cancer surgery. prior to the surgical removal of the cancer, the microwave antenna would be inserted into the tumor under ultrasound guidance (either percutaneously or open). the tumor would be ablated, and then surgically resected in a standard, curative fashion.

Eligibility criteria:
inclusion criteria: * a diagnosis of primary breast tumor for which a surgical resection (excisional, biopsy, segmentectomy or mastectomy) is planned. * tumor is palpable or visible on ultrasound or both * all participants need to be fully able to give informed consent exclusion criteria: * gender: male * mental or legal incompetence * impaired decision-making capacity * pregnant women may not participate * implanted pacemaker

Keywords: breast cancer tumors
long term follow up of water vapor thermal therapy (rezum) for benign prostatic hyperplasia (bph)

Conditions: Benign Prostatic Hyperplasia

Summary: in this study the investigators are assessing the effectiveness and morbidity of rezum therapy for benign prostatic hyperplasia by collect data and assess all patient who treated by rezum from 2 to 4 years and report these results.


Eligibility criteria:
inclusion criteria: * patients underwent rezum procedure for benign prostatic hyperplasia from 2 to 4 years exclusion criteria: * previous prostatic intervention * concurrent urological morbidity like urethral stricture * neurological disease like parkinson's disease
effects of time-restricted hypocaloric diet in patients with nafld

Conditions: Non-Alcoholic Fatty Liver Disease

Summary: the effects of a time-restricted hypocaloric mediterranean type diet compared to a conventional hypocaloric mediterranean type diet on blood glucose metabolism and liver steatosis in people with non-alcoholic fatty liver disease will be investigated.

the goal of this clinical trial is to evaluate the effects of the time in which food intake is restricted (morning or evening hours or no restriction in time) on glucose metabolism and liver steatosis in the context of a hypocaloric diet plan in 54 patients with non-alcoholic fatty liver disease (nafld). the participants will be divided into 3 groups of 18 individuals each and will be randomly assigned to one of the 3 dietary interventions. in the first group (control group), participants will be given a weight loss program based on the principles of the mediterranean diet (energy deficit of 500 kcal/day with the aim of losing 0.5 kg per week) with the instruction to consume their meals throughout the day, without time restriction. in the second group (early eaters), individuals will be given a weight loss program based on the principles of the mediterranean diet (energy deficit of 500 kcal/day with the aim of losing 0.5 kg per week), and they will be asked to consume all of their meals within 10 hours (between 07:00-09:00 and 17:00-19:00) and refrain from consuming caloric foods and drinks for the remaining 14 hours. in the third group (late eaters), individuals will be given a weight loss program based on the principles of the mediterranean diet (energy deficit of 500 kcal/day with the aim of losing 0.5 kg per week), and they will be asked to consume all of their meals within 10 hours (between 11:00-13:00 and 21:00-23:00) and refrain from consuming caloric foods and drinks for the remaining 14 hours.

Eligibility criteria:
inclusion criteria: * body mass index \>25 kg/m2 * liver steatosis with magnetic resonance elastography (mre) exclusion criteria: * other chronic liver diseases * alcohol consumption \>20 g/day (female) and \>30 g/day (male) * medications that cause liver disease or secondary nafld (e.g. tamoxifen, corticosteroids, methotrexate, tetracycline, estrogens, valproic acid) * changes in body weight ± 3 % in the last 3 months * patients following a hypocaloric diet program and/or time-restricted feeding and/or other intermittent fasting protocols * unstable glucose-lowering medications in the last 6 months * body weight lowering medications and/or history of bariatric surgery * statins and/ or other fat-reducing medications if not taken in steady dosage for at least 3 months * uncontrolled type 2 diabetes mellitus defined as hba1c value \> 9.0% or insulin depending type 1 and 2 diabetes mellitus * pregnancy * lactation * immunologic or inflammatory diseases * depression and other psychiatric diseases * patients working in shifts * cancer

Keywords: time-restricted feeding mediterranean diet
accuracy of an artificial intelligence-assisted diagnostic system for caries diagnosis: a prospective multicenter clinical study

Conditions: Dental Caries; Artificial Intellegence; Diagnosis; Machine Learning

Summary: this clinical trial was designed as a prospective, multicenter, multi-reader multi-case (mrmc), superiority, parallel-controlled study. participants who met the trial criteria and signed the informed consent form were enrolled. the trial group involved diagnoses of caries on panoramic radiographs using an artificial intelligence-assisted diagnostic system, while the control group involved diagnoses made by dental practitioners specializing in operative dentistry and endodontics with five years of experience, who interpreted oral panoramic radiographs to determine the presence and severity of caries.


Eligibility criteria:
inclusion criteria: - inclusion criteria: 1. patients presenting with clinical manifestations of caries as their chief complaint; 2. age ≥18 and ≤70 years, irrespective of gender; 3. oral panoramic radiographs showing a complete dentition, specifically with the second molars and all premolars intact in each quadrant; 4. on the oral panoramic radiographs, the number of teeth with restorations or fillings does not exceed one in any quadrant; 5. oral panoramic radiographs that are clear, easy to interpret, and free from significant artifacts; 6. participants who voluntarily agree to partake, can comprehend the purpose of the study, and are capable of signing an informed consent form. exclusion criteria: 1. oral panoramic radiographs that are unclear, with overlapping, blurring, or artifacts present; 2. insufficient number of teeth available for study; 3. severe tooth wear or erosion leading to significant alteration in tooth morphology; 4. presence of supernumerary teeth, microdontia, or missing teeth; 5. conditions not suitable for oral radiography, such as pregnancy or undergoing radiation therapy for tumors; 6. limited mouth opening that precludes clinical examination; 7. neurological disorders, psychiatric illnesses, or psychological impairments; 8. participation in another clinical trial within the last three months; 9. any other condition deemed by the researchers as unsuitable for inclusion in the study.

Keywords: dental caries ai diagnosis
moya moya syndrome with or withtout sickle cell disease

Conditions: Moya Moya Disease

Summary: moya moya disease or syndrome ar characterized by a progressive or occlusion of the intracranial carotid arteries and their mainproximal branches, followed by the development of fragile neovessels at the base of the skull, leding to a high risk of both ischemic and hemorragic stroke over time. moya moya syndrome are associated to a variety of disease, which main frequent is sickle cell disease (scd). among patients with scd who had suffered from at least one ischemic stroke, the prevalence of moya moya syndrome was estimated up to 43%. in general, therapeutic strategies in moya moya to prevent first ever ou recurrent stroke can be divided into conservative medical treatment and surgical revascularisation (direct bypass, indirect bypass or combined bypass). the aim of this study is to compare prognosis of patients with moya moya syndrome associated with sickle cell disease or not. the investigators retrospectiveluy analysed medical chart from 2010 to 2021 of patients with moya moya disease or syndrome at two french university hospitals (including a center of the french west indies where prevalence of sickle cell disease is high). the diagnosis was based on angiography or mri records showing uni- or bilateral stenosis of distal intracranial internal carotide arteries or middle cerebral arteries associated wirh classic collateral network. main endpoint will be comparison of a composite outcome defined as time from moya moya diagnosis to first or recurrent stroke or bad prognosis achivement (defined by modified rankin score \>2)


Eligibility criteria:
inclusion criteria: * age \>=15 * patients at diagnosis of moya moya disease and syndrome exclusion criteria: * misclassified patients * clinical diagnosis of mm not confirmed by angiography or mri

Keywords: moya moya syndrome moya moya
lower limb flexor synergy training in chronic stroke

Conditions: Stroke

Summary: this study evaluates whether a 4-week exercise training program focusing on lower limb flexors can improve lower limb motor function late after stroke. it is hypothesized that there would be significant improvements in gait and strength of the flexor muscles as a result of the training. it is also hypothesized that the training effects, if any, would be retained at 4 weeks after ending the training.

it is known that the muscles that flex the hip, knee, and ankle joints are responsible for bringing the leg up and forward during walking and for a successful recovery from a slip or trip. many previous studies have focused on strengthening the lower limb muscles that support the body in standing and walking (the so-called anti-gravity extensor muscles) but the training targeting the lower limb flexors has rarely been emphasized in stroke rehabilitation. therefore, it is the intent of this exploratory study to find out whether an exercise training program focusing on lower limb flexors can improve lower limb motor function late after stroke. ten participants with chronic stroke will be recruited. their lower limb muscle function and walking performance will be assessed at baseline (2 to 3 times within the 2 weeks prior to starting the training), at the end of training, and 4 weeks later. each subject will perform biking exercises under supervision, 2-3 times per week for 4 weeks (30 minutes each). the bike pedals are moving backward at a preset speed regardless of user effort. with feet strapped to the pedals, the participant will be asked to activate the hip, knee, and ankle flexors simultaneously when the pedal is moving up and then relax. heart rate (hr) will be monitored continuously using a fingertip pulse monitor to ensure the maximum training hr is no more than 75% of the subject's hr reserve.

Eligibility criteria:
inclusion criteria: * time post-stroke between 6 months and 3 years * able to walk with or without an assistive device for 7 m independently * abnormal flexor synergy in both hip and knee joints (score 1 or 2) on the fugl-meyer assessment lower extremity section ii: volitional movement within synergies (fugl-meyer et al., 1975) * walk slower than 1 m/s * able to understand and follow simple instructions * agree not to participate in strength training or supervised physical therapy during and for at least 4 weeks after the completion of training * previous participation in the physical therapy program for stroke without experiencing excessive symptoms (shortness of breath, headache, prolonged fatigue) exclusion criteria: * current symptomatic coronary artery disease or congestive heart failure * history of myocardial infarction * uncontrolled hypertension (\>150/90 mm hg) * lower limb fracture in the past 6 months * lower limb joint or muscular problems * acute or terminal illness * current participation in strength training or supervised physical therapy
a real-world study of anti-sars-cov-2 monoclonal antibodies

Conditions: Immunocompromised Patients

Summary: absence of anti-sars-cov-2 vaccine response or insufficient vaccine response may occur in immunocompromised patients. being at high risk of a severe form of covid-19, they may be eligible to receive recombinant anti-sars-cov-2 monoclonal antibodies (mabs). this study aims to describe patients who received anti-sars-cov-2 mabs, in prophylaxis and/or curative of covid-19, and to analyze the hospitalization and mortality rates. this study is multicentric on all the university hospitals of paris (ap-hp).


Eligibility criteria:
inclusion criteria: * adult ≥ 18 years old * patients who received at least one administration of the following therapies: casirivimab-imdevimab, bamlanivimab-etesevimab, tixagevimab-cilgavimab, regdanvimab, sotrovimab or adintrevimab exclusion criteria: * patients opposed to the collection of their personal data

Keywords: covid-19 sars-cov-2 immunocompromised monoclonal antibodies mortality
study of pap smears from patients enrolled on clinical trial gog-171

Conditions: Cervical Cancer; Precancerous Condition

Summary: rationale: studying pap smears in the laboratory from women with atypical glandular cells of unspecified significance may help doctors learn more about changes that may occur in dna and identify biomarkers related to cancer. purpose: this research study is looking at pap smears from women enrolled on clinical trial gog-171.

objectives: primary * to determine the diagnostic accuracy of using previously reported morphometric criteria for chromatin distribution, shortest distance between nuclei, and/or the ratio of nucleoli area to nucleus area in a conventional pap smear from patients with a cytologic diagnosis of atypical glandular cells of unspecified significance (agus) to predict the presence of significant glandular lesions (i.e., adenocarcinoma in situ \[ais\] or invasive cancer) and/or squamous lesions (i.e., cervical intraepithelial neoplasia \[cin2 or cin3\]) of the cervix. secondary * to optimize the diagnostic accuracy of using chromatin distribution, shortest distance between nuclei, and/or the ratio of nucleoli area to nucleus area in a conventional pap smear from patients with a cytologic diagnosis of agus to predict the presence of significant glandular lesions (i.e., ais or invasive cancer) and/or squamous lesions (i.e., cin2 or cin3) of the cervix. outline: previously collected slides from pap smears of patients enrolled on clinical trial gog-171 are assessed for nuclear chromatin distribution, the shortest distances between the central points of neighboring cell nuclei, and nucleoli area/nucleus area (n/n) ratio via morphometric analysis.

Eligibility criteria:
disease characteristics: * cytologically confirmed atypical glandular cells of unspecified significance * original pap smear used to define the diagnosis must be available for review * previously enrolled by gog-japan onto clinical trialgog-171 * must have been eligible and evaluable for the primary objective of gog-171 * gave permission to use specimens for future cancer research in gog-171 * underwent a loop electrosurgical excision procedure/large loop excision of the transformation zone (leep/lletz) procedure on clinical trial gog-171 to determine the presence of cervical intraepithelial neoplasia (cin-2 or cin-3), significant glandular lesions (ais), or invasive cancer patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: cervical cancer cervical intraepithelial neoplasia grade 2 cervical intraepithelial neoplasia grade 3 cervical adenocarcinoma atypical squamous cells of undetermined significance
effects of herbal products on reduction of radiation-induced dermatitis in breast cancer patients

Conditions: Radiodermatitis; Breast Neoplasms; Adverse Effect of Radiation Therapy

Summary: the herbal products on reduction of radiation-induced dermatitis in patients with breast cancer

to compare the effect of each herb extracts to protect the skin from the adverse effects of radiation therapy in patients with breast cancer with herbal extract products.

Eligibility criteria:
inclusion criteria: * aged 20 years old or older, * diagnosed with breast cancer * on course of external radiation therapy exclusion criteria: * pregnant * previously underwent external radiation therapy * illiterate

Keywords: herbal products reduction of radiation-induced dermatitis breast cancer radiotherapy
prevention of graft reinfection after liver transplantation with anti hcv monoclonal antibodies identified in chronically infected patients or in patients with resolved hepatitis c

Conditions: Hepatitis C

Summary: end stage hcv-related cirrhosis has become a major indication for liver transplantation (lt). unfortunately, recurrence of hcv infection on the liver graft occurs in almost all patients following transplantation and causes a persistent infection that leads to chronic hepatitis and cirrhosis in a significant proportion of patients. to date there is no effective way to prevent hcv reinfection of the liver graft in the early phase after transplantation. . early passive immunotherapy with neutralizing antibodies against hcv should be considered for preventing reinfection of liver transplanted patients associated with hcv. this approach is well established in the case of patients undergoing liver transplantation for chronic hepatitis b virus infection. our purpose is to produce neutralizing monoclonal antibodies to prevent reinfection of the liver graft.


Eligibility criteria:
inclusion criteria: * health insurance * resolved hcv infection ( hcv rna negative since more then 6 months ) -hcv chronically infected ( rna positive ) * anti- hcv antibodies positive * volunteers and informed patients exclusion criteria: * immunosuppression * hbv or hiv infection * pregnancy * breast feeding

Keywords: hepatitis c liver transplantation antibodies mediated neutralization monoclonal antibodies
validation of the utility of rare disease intelligence platform

Conditions: Cataract; Artificial Intelligence

Summary: the prevention and treatment of diseases via artificial intelligence represents an ultimate goal in computational medicine. the artificial intelligence for systematic clinical application has not yet been successfully validated. currently, the main prevention strategy for rare diseases is to build specialized care centers. however, these centers are scattered, and their coverage is insufficient, resulting in inadequate health care among a large proportion of rare disease patients. here, the investigators use "deep learning" to create cc-cruiser, an intelligence agent involving three functional networks: "pick-up networks" for diagnostics, "evaluation networks" for risk stratification and "strategist networks" to provide assisted treatment decisions. the investigator also establish a cloud intelligence platform for multi-hospital collaboration and conduct clinical trial and website-based study to validate its versatility.


Eligibility criteria:
inclusion criteria: * patients who underwent ophthalmic examination of the eye and recorded their ocular information in the collaborating hospital. exclusion criteria: -
plethysmography as a useful intraoperative monitor

Conditions: Cardiovascular Diseases

Summary: data from both the traditional invasive cardiac monitors and the nonin will be collected simultaneously. the investigators will analyze nonin data for peak and trough variation with respiration, area under the curve, time from trough to peak, and slope, and compare these to data collected from the invasive monitors to look for correlations in clinically important parameters such as blood pressure, central venous pressure, cardiac output, etc.

after obtaining written consent to participate, the standard of care arterial line and pa catheter will be placed pre-operatively. the investigators will attach the nonin pulse oximeter, as a second pulse oximeter probe, to patients undergoing surgical procedures which already require invasive cardiac monitors (arterial line, pulmonary artery catheter, etc). data from both the traditional invasive cardiac monitors and the nonin pulse oximeter will be collected as electronic files. once both files are compiled they will be de-identified. the investigators will also record medications and iv fluids given during surgery. the nonin pulse oximeter is clinically marketed for this indication the investigators will analyze nonin data for peak and trough variation with respiration, area under the curve, time from trough to peak, and slope, and compare these to data collected from the invasive monitors to look for correlations in clinically important parameters such as blood pressure, central venous pressure, cardiac output, etc.

Eligibility criteria:
inclusion criteria: * 18 years of age and older patient scheduled for surgery that will have both an arterial catheter and a pulmonary artery catheter as standard of care informed consent exclusion criteria: * only the above inclusion criteria apply

Keywords: plethysmography