Kornimate/medical-research-clean huggingface dataset:
portable pves study

Conditions: Lower Urinary Tract Symptoms

Summary: a comparative study will be conducted and the patient will undergo a conventional urodynamic study. in order to successfully determine if the peritron+ is capturing vesical pressure measurements consistent with conventional urodynamics the two sources of pves will be collected concurrently.


Eligibility criteria:
inclusion criteria: * patients normally indicated for urodynamic evaluation exclusion criteria: * patients who suffer from bladder infections * patients who suffer from strictures in the urethra
comparison of pdt, intravitreal ranibizumab and combination for polypoidal choroidal vasculopathy under 1+prn regimen

Conditions: Polypoidal Choroidal Vasculopathy

Summary: the aim of this study is to compare the outcomes of different treatment methods including photodynamic therapy (pdt), intravitreal ranibizumab injection (ivr) and combination therapy under the "1+prn" treatment regimen for polypoidal choroidal vasculopathy (pcv) and find the optimal treatment for pcv.

the optimal treatment for pcv is still under debate. little knowledge is known about the treatment effect of "1+pro re nata(prn)" treatment regimen for pcv. the aim of this study is to compare the outcomes of different treatment methods including pdt, ivr and combination therapy under the "1+prn" treatment regimen for pcv. the study is the first prospective randomized controlled trial about different treatment methods on pcv under "1+prn" treatment regimen. the null hypothesis of the study is that combination therapy may be the optimal treatment method for pcv. the primary outcome measures is the best-corrected visual acuity (bcva) of the participants at 1 year after treatment. besides, the slit-lamp examination, tonometry, funduscopy, and oct, ffa, icga examinations will also be compared between different groups to find the optimal treatment for pcv.

Eligibility criteria:
inclusion criteria: 1. active macula-involved polypoidal lesions evidenced by icga; 2. greatest linear dimension of 5400 μm or less assessed by icga; 3. follow-up of at least 12 months. exclusion criteria: 1. any other ocular disease, such as ocular trauma, glaucoma, uveitis, diabetic retinopathy, angioid streaks, pathologic myopia, or presumed ocular histoplasmosis syndrome; 2. any systemic contraindication to the pdt, ivr, sodium fluorescein, or indocyanine green dyes; 3. any severe uncontrolled systemic disease, such as uncontrolled hypertention, coronary heart disease, liver failure, or kidney failure.

Keywords: polypoidal choroidal vasculopathy photodynamic therapy ranibizumab combination therapy cost-benefit
prospective observational lymphoedema intensive treatment

Conditions: Lymphoedema

Summary: the aim of this observational study was to describe usual practices in lymphedema management in france. it was the opportunity to assess the effects of these practices on lymphedema volume in a large number of patients, to identify predictive factors of response, and to assess the safety of this therapy.

lymphoedema is commonly treated according a strategy called complex decongestive therapy (cdt). this cdt is usually composed of 2 different treatment phases. the first phase is an acute phase which aim is to reduce affected limb volume. the second phase is a maintenance phase which aim is to maintain as long as possible the volume reduction acheived during the first phase. these 2 phases required multi modal parameters such as bandages, lymphatic drainages, physical exercises...and can be managed very differently from one site to another.

Eligibility criteria:
inclusion criteria: * consecutive adult patients * hospitalized with a clinical diagnosis of unilateral stage ii-iii upper or lower limb lymphoedema of any etiology * indication for intensive decongestive therapy (idt) exclusion criteria: * bilateral lymphedema, * lymphedema of both upper and lower limbs, * intensive decongestive therapy in the previous 6 months, * cancer recurrence, * systolic pressure index \< 0.5
study on laparoscopic d2 lymphadenectomy plus complete mesogastrium excision（d2+cme）for advanced gastric cancer

Conditions: Gastric Cancer

Summary: radical gastrectomy for gastric cancer with d2 lymph node dissection has been widely applied in advanced gastric cancer. however,for most patients,tumor local-regional recurrence has been proven unavoidable. recently, many clinical studies have proved that some cancer cells and cancer nodes exist in the mesogastrium which can be hardly removed by conventional radical gastrectomy with d2 lymphadenectomy. it is suggested that complete mesogastrium excision (cme) is imperative and should be added to d2 lymphadenectomy in order to reduce the risk of local recurrence. thus, the comparison of short-term and long-term outcome between laparoscopic d2 lymphadenectomy plus complete mesogastrium excision and conventional laparoscopic d2 lymphadenectomy for locally advanced gastric cancer based on a well designed randomized controlled trial is needed.


Eligibility criteria:
inclusion criteria: age from over 18 to under 75 years primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy ct2-4a, n0-3, m0 at preoperative evaluation according to the ajcc cancer staging manual seventh edition expected curative resection through gastrectomy with d2 lymphadenectomy performance status of 0 or 1 on ecog (eastern cooperative oncology group) scale asa (american society of anesthesiology) score class i, ii, or iii informed consent obtained from patients or their appointed agent exclusion criteria: patients treated with neoadjuvant chemotherapy or radiation therapy; patients with history of upper abdominal surgery; history with other severe comorbidities and cannot tolerate laparoscopic surgery, such as severe heart and lung diseases, heart function below clinical stage 2, pulmonary infection, moderate to severe copd, chronic bronchitis, severe diabetes and / or renal insufficiency, severe hepatitis and / or function below the rank of child b grade, and severe malnutrition, etc; patients suffering from malignant diseases before the study or with other gastric malignant diseases, such as lymphoma and stromal tumors, etc.; pregnant woman and woman during lactation; patients with mental sickness; the patient compliance is bad or the researcher expect there will not be good patient compliance;

Keywords: d2 lymphadenectomy complete mesogastrium excision
screening of attrwt in patient with advanced av-block undergoing pacemaker implantation

Conditions: Amyloid Cardiomyopathy; Block, AV

Summary: the investigators will nationally investigate the prevalence of transthyretin amyloidosis wildtype (attrwt) in patients of ≥ 65 years with left ventricular hypertrophy who present with high degree atrioventricular block (av-block) and are admitted for pacemaker implantation. the investigators aim to characterize the group of patients with positive screening of attr and compare the attrwt disease stage at time of diagnosis for patients identified with attr at screening with a control group of routinely clinically diagnosed attrwt patients.


Eligibility criteria:
inclusion criteria: * men ≥65years or women ≥75years with unexplained av-block with pacemaker indication, as decided per treating physician and presence of left ventricular hypertrophy ≥12mm. exclusion criteria: * reversible causes for av-block, som as av-node disturbing medicament, ion-disturbances, hypothyroidism, hypoxia, ischemia, new heart surgery \<1month, endocarditis.
self-care for lymphedema in patients with breast cancer

Conditions: Breast Cancer

Summary: rationale: identifying why patients don't do self care for lymphedema may help doctors plan better at-home self-care treatment. purpose: this research study is looking at self-care practices for lymphedema in patients with breast cancer.

objectives: primary * to systematically identify and describe the barriers to completing recommended at home self-care of lymphedema in patients with breast cancer. * to identify patient recalled instructions as to at home self-care practices for lymphedema as told to them by healthcare professionals and others. * to identify the current at home self-care practices of breast cancer survivors with treatment treated lymphedema. secondary * to examine the relationship between at home self-care activities and symptoms in breast cancer survivors with lymphedema. * to examine the relationship between at home self-care activities and quality of life in breast cancer survivors with lymphedema. * to identify patient-perceived benefits to at home self-care. outline: patients complete questionnaires about their breast cancer diagnosis and treatment history, lymphedema history and problems, and years of education and income. patients also complete surveys about home self-care practices for lymphedema and any benefits, burdens, or barriers of at home care.

Eligibility criteria:
disease characteristics: * history of breast cancer * lymphedema in one or both arms that occurred during or after breast cancer treatment * must have received prior lymphedema treatment by a healthcare professional * patients with self-reported arm swelling subsequent to breast cancer treatment that has not been treated by a healthcare professional are not eligible * hormone receptor status not specified patient characteristics: * menopausal status not specified * english speaking prior concurrent therapy: * see disease characteristics

Keywords: male breast cancer recurrent breast cancer stage i breast cancer stage ii breast cancer stage iiia breast cancer stage iiib breast cancer stage iiic breast cancer stage iv breast cancer
irrigation and suction trial to prevent ssi

Conditions: Surgical Site Infection; Diabete Mellitus; Abdominal Hysterectomy

Summary: the study will be conducted on women with risk factors for ssi assigned to gynecological surgery with an open abdominal approach. the participants will be designated to either irrigation and suction arm by bilateral drain insertion or the control arm by randomization through the parallel assignment. the participants will be followed for the outcome for four days in the hospital and then at 4 weeks, 8 weeks and 12 weeks postoperatively. the primary outcome measure will be the ssi rate. secondary outcomes will be signs of ssi, post-operative pain, other complications and patient satisfaction.

this study will be carried out in lady willingdon hospital, lahore. in this study, we will recruit middle-aged and elderly diabetic women who have been assigned to open abdominal hysterectomy due to different gynaecological reasons. this cohort is at great risk of surgical site infection and other risk factors of ssi like hypertension, hepatitis and malignancy may coexist in these women. the study period will span to include three hundred participants as calculated according to sample size. the women will be divided into either an i\&s group or a control group by a simple random number container method. the women in the i\&s group will be inserted with bilateral drains during surgery in subcutaneous tissue after the closure of the rectus sheath and irrigated with saline followed by suction through syringe suction attached to the wound for rest of the day. the procedure will continue for three days. on the fourth day, drains are removed and stitches are removed on the fourth postoperative day. in the control group, the wound will be closed by interrupted stitches without the insertion of subcutaneous drains. the dressing will be done daily for seven days. patients with no symptoms and signs of ss will be sent home on the eighth postoperative day. the patients will be followed for symptoms of ssi, pain, readmission rate, and other complications at 4,8 and 12 weeks.

Eligibility criteria:
inclusion criteria: * diabetic patients * age above 40years * bmi\>25kg/m2 * assigned to hysterectomy * fit for anaesthesia * patients with other medical disorders like hepatitis and hypertension will also be included in the study. exclusion criteria: * a bmi of less than 25kg/m2 * a preoperative haemoglobin level of less than 10 g/dl.

Keywords: suction, wound healing pain hysterectomy
pain on injection of propofol: a comparison of lidocaine and alkalinized lidocaine

Conditions: Pain on Injection of Propofol,Lidocaine, Alkalinized Lidocaine

Summary: aim: the aim of this study was to compare the efficacy of pretreatment 0.5 mg/kg lidocaine and 0.5 mg/kg alkalinized lidocaine for prevention of propofol induced pain. methods: in this double-blind, placebo controlled study, 300 adults patients asa i or ii, scheduled to undergo elective surgery, were randomly assigned into three groups of 100 each. group l, recevied 0.05 ml/kg lidocaine (% 2 lidocaine 5 ml + 5 ml sf), group a, 0.05 ml/kg lidocaine with bicarbonate ( % 2 lidocaine 5 ml + 1 ml %8,4 nahco3+ 4 ml sf) and control group received isotonic saline pretreatment in the dorsum of the hand, followed by propofol 30 sec later. a blinded researcher assessed the patient's pain level via a four-point scale.


Eligibility criteria:
inclusion criteria: * undergoing elective surgery exclusion criteria: * allergy to the study drug
skin prep to reduce postoperative shoulder infection

Conditions: Shoulder Infection

Summary: propionibacterium acnes is the most common pathogen identified from a surgical site infection in the shoulder. standard skin preps do not prevent this type of infection. patients will undergo either a chlorhexidine or benzoyl peroxide prep in days leading up to surgery. bacterial burden will be determined at the time of surgery.

after surgical posting, patients will be randomized to chlorhexidine or benzoyl peroxide group. the solutions used will be 5% benzoyl peroxide emollient foam and 4% chlorhexidine gluconate skin cleanser. participants will be instructed to conduct skin wash using the appropriate solution in the shower over the operative shoulder and axilla for three mornings prior to surgery (pre op day -2, pre op day -1, and morning of surgery). specific instructions will include leaving the solution on the skin for three minutes and avoiding contact with eyes, ears, and mouth. proper technique will be demonstrated at time of patient recruitment and given as a handout with the wash solution provided. a reminder phone call will occur two days before surgery to remind patients of proper procedure to improve compliance. on the day of surgery, patients be interviewed about pre-operative compliance. on the day of surgery, two cultures will be taken in three separate sites on both shoulders (anterior, lateral, and posterior) using a detergent scrub technique, the current dermatologic standard for biopsy of the deep sebaceous glands. (3,11) this procedure is typically performed on the skin of awake patients and causes minimal pain and skin irritation. cultures will be evaluated in our lab. we will also test for hemolysis as a possible indicator of a more virulent strain in the literature. the research team may take photos of the shoulder skin being swabbed. photos will not include the facial or defining characteristics. photos may be taken either in the clinic at time of recruitment or in the operating room when samples are being taken. inclusion criteria: all patients undergoing open shoulder surgery or shoulder arthroscopy. exclusion criteria: anyone with a history of allergic reaction to chlorhexidine or benzoyl peroxide. anyone with a history of previous shoulder infection, current open skin lesions around the shoulder or the use of current anti-acne medications around the shoulder. healthy volunteer portion: healthy volunteers will respond to the study from fliers on campus. a cotton swab test on both shoulders will be performed prior to any treatment. if a threshold of p. acnes is met (\>1000 colony forming units (cfus)) then volunteers will be randomized to the same two groups and retested after three days of unilateral treatment. finally, volunteers will undergo repeat cotton swab testing one week after 3 day wash was finalized.

Eligibility criteria:
inclusion criteria: * age \>18 * indicated for shoulder surgery exclusion criteria: * history of previous shoulder infection * allergy to chlorhexidine or benzoyl peroxide * current use of anti-acne medicine around the shoulder * patient is pregnant or concerned about pregnancy
a study designed to evaluate the safety and efficacy of venetoclax plus dexamethasone (vendex) compared with pomalidomide plus dexamethasone (pomdex) in participants with t(11;14)-positive relapsed or refractory multiple myeloma.

Conditions: Multiple Myeloma

Summary: a study designed tocompare progression-free survival (pfs) in participants with t(11;14)-positive mm treated with venetoclax in combination with dexamethasone versus pomalidomide in combination with dexamethasone.


Eligibility criteria:
inclusion criteria: * documented diagnosis of multiple myeloma (mm) based on standard international myeloma working group (imwg) criteria. * measurable disease at screening as defined per protocol. * has received at least 2 prior lines of therapy as described in the protocol. * has had documented disease progression on or within 60 days after completion of the last therapy. * has received at least 2 consecutive cycles of lenalidomide and be relapsed/refractory to lenalidomide, as defined per protocol. * has received at least 2 consecutive cycles of a proteasome inhibitor (pi). * has t(11;14)-positive status determined by an analytically validated fluorescent in situ hybridization (fish) assay per centralized laboratory testing. * an eastern cooperative oncology group (ecog) performance status less than or equal to 2. * laboratory values (liver, kidney and hematology laboratory values) that meet criteria as described per protocol. exclusion criteria: * history of treatment with venetoclax or another b-cell lymphoma (bcl)-2 inhibitor or pomalidomide. * history of other active malignancies, including myelodysplastic syndromes (mds), within the past 3 years (exceptions described in the protocol). * evidence of ongoing graft-versus-host disease (gvhd) if prior stem cell transplant (sct). * prior treatment with any of the following: allogeneic or syngeneic sct within 16 weeks prior to randomization; or autologous sct within 12 weeks prior to randomization. * known central nervous system involvement of mm. * concurrent conditions as listed in the protocol.

Keywords: cancer, multiple myeloma (mm), relapsed or refractory multiple myeloma (r/r mm), pharmacokinetics canova
rapid urease test for diagnosis helicobacter pylori infection

Conditions: Helicobacter Pylori Infection

Summary: nowadays, the gold standard examinations for diagnosing h. pylori infection are histopathology and culture examination. however, those examinations take long preparation so they are not suitable to be applied in daily practice. in progress, another examination is being developed to detect urease enzyme from tissue biopsy. it is relatively faster in diagnosing h. pylori infection. some commercial urease tests which are available in indonesia are helicotec® and pronto dry®. this study aims to determine the effectivity of helicotec® in diagnosing h. pylori infection. it is expected to be scientific evidence that can be used as the basis daily routine of urease test in diagnosing h. pylori infection.

this study is a diagnostic study. there will be 97 dyspepsia patients who met the inclusion and exclusion criteria. they will answer the questionnaire about personal data and examined physically. they will also undergo endoscopy, biopsy, and urease test using helicotec®

Eligibility criteria:
inclusion criteria: * adult (18-55 years old), * diagnosed with dyspepsia, * indicated for endoscopy, * agreed to participate in the study and signed the informed consent. exclusion criteria: * pregnancy and breastfeeding woman, * patients with alarm symptom, * history taking of antibiotics (amoxicillin, clarithromycin, levofloxacin), h2 receptor antagonist, proton pump inhibitor, misoprostol, sucralfat, bismuth, nsaids, steroid, rheumatoid drug within the last 2 weeks.

Keywords: helicobacter pylori urease test helicotec
prevention of eating habits associated with obesity

Conditions: Obesity, Adolescent; Eating, Healthy

Summary: this study evaluates the effectiveness of a wise intervention based on a values alignment approach to improve obesity-related eating habits in spanish adolescents. half of the participants will receive the experimental intervention, while the other half will receive a control intervention.

obesity in adolescence is associated with physical and mental health problems and predicts obesity in adulthood. adolescence may be an ideal time to target interventions, as this is when numerous health-related habits are consolidated. several universal preventive interventions have been carried out in educational centers for the promotion of healthy eating habits. however, the results of reviews and meta-analyses have concluded that most are not cost-effective for producing long-term changes in the dietary preferences of young people. the so-called wise interventions paradigm is an innovative approach to interventions that involve a set of rigorous techniques grounded in research to help people improve in a variety of life settings. recently, it has been developed a wise intervention aimed at improving adolescents' daily dietary choices. this intervention, called the values alignment intervention, focused on the role of marketing on the behavior of children and adolescents who are exposed to a relentless barrage of marketing from the food industry. the values alignment intervention seeks to neutralize the positive emotional associations with junk food that marketing generates and presents the rejection of unhealthy foods in favor of healthy alternatives as a way to live up to two values that are important to adolescents: (1) the desire to be autonomous from adult control, and (2) the desire for social justice. in two randomized controlled trials, it has been demonstrated that the intervention reduced implicit positive associations with junk food and substantially improved dietary choices, especially in boys. in addition, there were significant differences in attitudinal variables related to healthy eating. these promising results suggest that reframing unhealthy eating as incompatible with important youth values could be a low-cost solution to produce changes in adolescent attitudes and dietary choices. therefore, the general objective of this project is to adapt the values alignment intervention to improve obesity-related eating habits in spanish adolescents and evaluates its effectiveness. it is therefore a highly innovative project with great potential for social impact in the field of health promotion.

Eligibility criteria:
inclusion criteria: * informed consent by the adolescents and their parents. * to be fluent in spanish and/or euskera. exclusion criteria: * lack of permission by parents and the adolescent. * lack of understanding of the instructions.

Keywords: adolescence prevention healthy food intake unhealthy food intake wise intervention