Kornimate/medical-research-clean huggingface dataset:
auramine phenol staining technique for revealing different coccidian parasites

Conditions: Chronic Diarrhea

Summary: the increased number of documented human coccidian infections, including cryptosporidium parvum, cyclospora cayetanensis, isospora belli, and sarcocystis spp., that are often indistinguishable from other forms of community-acquired diarrhea, together with the possibility of treating some of them, suggests a need for proper diagnostic techniques to recover and identify these organisms

the increased number of documented human coccidian infections, including cryptosporidium parvum, cyclospora cayetanensis, isospora belli, and sarcocystis spp., that are often indistinguishable from other forms of community-acquired diarrhea, together with the possibility of treating some of them, suggests a need for proper diagnostic techniques to recover and identify these organisms. earlier, cryptosporidium and cystoisospora were assumed to be the causative agents of acute diarrhea in animals but recently have emerged as one of the leading causes of prolonged lifethreatening diarrhea in immunocompromised patients particularly in those with immune dysfunction like aids who may show severe intestinal injury, prolonged diarrhea, extreme weight loss, and generalized wasting. in contrast, healthy individuals commonly present with mild to moderate self-limiting diarrhea during the infective stage, besides asymptomatic infection can also occur. detection of coccidian parasites is mostly through microscopic observation using kinyon's acid-fast stain. although sheather sugar flotation may result in increased concentration of the cysts, this method is cumbersome and does not lend itself to convenient incorporation within the routine concentration and staining procedures favored in most clinical laboratories. any acid-fast stain will be taken up by cyst walls, but the time required to prepare and examine acid-fast stains on all stool samples received for routine parasitology would not be cost-effective unless the prevalence of coccidian parasites was shown to warrant such effort.

Eligibility criteria:
inclusion criteria: * patients complaining of chronic diarrhea . exclusion criteria: * patients taking antibiotics within the previous four weeks, and anti-parasitic drugs within the previous two weeks.

Keywords: coccidian parasites auramine phenol staining fluorescence microscopy modified ziehl nelseen cryptosporidium
sublobar resection for adenocarcinoma in situ/minimally invasive adenocarcinoma diagnosed by intraoperative frozen section (ectop-1019)

Conditions: Lung Adenocarcinoma; Frozen Section; Sublobar Resection

Summary: this is a clinical trial from eastern cooperative thoracic oncology project (ectop), numbered as ectop-1019. the goal of this clinical trial is to confirm the therapeutic effect of sublobar resection for ais/mia diagnosed by intraoperative frozen section.


Eligibility criteria:
inclusion criteria: 1. patients who sign the informed consent form and are willing to complete the study according to the plan; 2. aged from 18 to 80 years old; 3. ecog equals 0 or 1; 4. not receiving lung cancer surgery before; 5. resectable peripheral ct1n0m0 tumors; 6. single lung nodules with ground-glass dominant or pure ground-glass on ct, or multiple lung nodules with the major lesion being the aforementioned nodules; 7. adenocarcinoma in situ/minimally invasive adenocarcinoma diagnosed by intraoperative frozen section 8. not receiving chemotherapy or radiotherapy before. exclusion criteria: 1. not ct1n0m0; 2. cannot be completely resected by sublobar resection; 3. invasive lung adenocarcinoma or not lung adenocarcinoma diagnosed cytologically or pathologically; 4. receiving lung cancer surgery before; 5. receiving radiotherapy or chemotherapy.
effectiveness of a school wellbeing programme for internalising problems in irish primary school children

Conditions: Anxiety; Low Mood

Summary: the aim of this study is to assess the effectiveness of a school-based multi-component universal programme for the reduction of internalising problems (i.e. anxiety and low mood) in primary school pupils.

childhood and adolescence are important developmental phases for wellbeing and mental health. school has been noted in psychological literature to be a favourable environment for mental health initiatives, such as school-based programmes. universal programmes are programmes delivered to all pupils irrespective of perceived need and have several advantages, including having a wide reach, avoiding the need for screening and are less stigmatising. a lust for life is a universal school-based multi-component intervention whose target is to build well-being and emotional resilience in children. the programme was informed by evidence-based psychological approaches including cognitive behaviour therapy, positive psychology and mindfulness and consists of six lessons, each delivered by the pupils' school teacher on a weekly basis. the lessons involve classroom discussions, videos, classroom activities and homework assignments. study participants will complete the revised children's anxiety and depression scale short format, coping strategy indicator and self-efficacy questionnaire for children pre-intervention. following this, schools randomly assigned to the experimental group will receive a lust for life, while those randomly assigned to the control group will be placed on a sixteen-week waiting list. the questionnaire measures and a brief satisfaction scale will be completed by participants at post-intervention. in addition, a six-week follow-up assessment will determine whether the effects of the programme are sustained over a period of time. the programme will be delivered in the waiting list control group schools after the six-week follow-up assessment.

Eligibility criteria:
inclusion criteria: * child * enrolled in primary school in ireland * obtain written informed consent from parents/guardians * provide written assent exclusion criteria: * failure to meet inclusion criteria
open label phase 1 study in japan for patient with advanced solid malignancies

Conditions: Advanced Solid Malignancy; Advanced Solid Tumor

Summary: the purpose of this study is to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumour activity of ascending doses of azd5363 under adaptable dosing schedules in japanese patients with advanced solid malignancies.


Eligibility criteria:
inclusion criteria: * aged at least 20 years * histological or cytological confirmation of a solid malignant tumour, excluding lymphoma, that is refractory to standard therapies or for which no standard therapies exist * at least one lesion (measurable and/or non-measurable) that can be accurately assessed according to recist * world health organisation (who) performance status 0-1 with no deterioration over the previous 2 weeks and minimum life expectancy of 12 weeks * patients should be willing to remain in hospital until the completion of the first cycle including cycle 0, cycle 1, and cycle 2 day1 (as cycle 1 day 21) exclusion criteria: * clinically significant abnormalities of glucose metabolism as defined by any of the following: * diagnosis of diabetes mellitus type i or ii (irrespective of management) * baseline fasting glucose value of ≥7 mmol/l (126mg/dl) * glycosylated haemoglobin (hba1c) \>6.5% * spinal cord compression or brain metastases unless asymptomatic, treated and stable and not requiring steroids for at least 4 weeks prior to start of study treatment * inadequate bone marrow reserve or organ function * any evidence of severe or uncontrolled systemic diseases, including active bleeding diatheses, or active infection * with the exception of alopecia, any unresolved toxicities from prior therapy greater than ctcae grade 1 at the time of starting study treatment

Keywords: phase 1 advanced solid tumor akt ascending japanese
pearl-sc trial: a study of the efficacy, safety, and tolerability of a 623 administration in subjects with systemic lupus erythematosus

Conditions: Systemic Lupus Erythematosus

Summary: the purpose of this study is to evaluate the efficacy, safety and tolerability of three different doses of a-623 administered in addition to standard therapy in subjects with active sle disease


Eligibility criteria:
inclusion criteria: * diagnosis of sle by american college of rheumatology guidelines. * on stable sle treatment * active sle disease * serologically active * 18 years of age or older * receiving stable doses of prednisone between 7.5 mg and 40 mg per day exclusion criteria: * severe active vasculitis, active central nervous system lupus, active lupus nephritis, uncontrolled hypertension, or uncontrolled diabetes. * known to be positive for hiv and/or positive at the screening visit for hepatitis b, or hepatitis c. * liver disease. * anemia, neutropenia, or thrombocytopenia. * malignancy within past 5 years * active infection requiring hospitalization or treatment with parenteral antibiotics within the past 60 days or history of repeated herpetic viral infections. * history of active tuberculosis or a history of tuberculosis infection. * participation in the active treatment arm of any phase 2 or phase 3 clinical trial for a molecule that primarily targets the b cell pathway in the past 18 months. * prior administration of any b cell depleting therapy in the past 18 months. * pregnant or nursing * history of congenital immunodeficiency

Keywords: sle lupus lupus erythematosus, systemic autoimmune diseases a-623 blisibimod
pilot study of bao-g technique in taaa endovascular repair

Conditions: Aortic Aneurysm, Thoracoabdominal

Summary: multi-branch aortic reconstruction with g-iliac system (bao-g) technique is a novel technique of endovascular repair of thoracoabdominal aortic aneurysm, which using off-the-shelf iliac branched devices to reconstruct the visceral branches. this study aims to evaluate the safety and efficacy of bao-g in thoracoabdominal aortic aneurysm endovascular repair.


Eligibility criteria:
inclusion criteria: 1. patients with taaa, confirmed by aortic cta. 2. taaa diameter ≥ 6cm, or symptomatic taaa with diameter ≥ 4cm. 3. informed consent signed. exclusion criteria: 1. were pregnant. 2. had a history of previous endovascular or open repair. 3. had other contraindications of endovascular treatment. 4. uncontrolled autoimmune disease.

Keywords: bao-g technique thoracoabdominal aortic aneurysm iliac-branched devices endovascular repair
feasibility of sending a direct send hpv self-sampling kit to long-term screening non-attenders

Conditions: HPV; Cervical Cancer

Summary: all women in one swedish county who had not participated in the organized screening program for at least 10 years were sent an hpv self-sampling kit. women who were positive for hpv were referred to a gynecological examination including colposcopy and further testing according to national guidelines.

in this cohort study nested in the organized cervical screening program, all women who had not participated in the organized screening program for at least 10 years in one swedish county were eligible. women were identified through the screening hub register that administrates for all invitations, referrals, and monitoring of the cervical screening program. the county screening hub invites approximately 30 000 women yearly to routine screening. those who had opted out of the screening program, undergone hysterectomy, or changed their personal identification number (pnr) were excluded. hpv self-sampling kits with instructions and invitation letters were sent from the department of laboratory medicine, falun hospital, in batches over 4 weeks. lists of invitees were checked against changes in the screening hub register for individuals who moved, emigrated, died, or had taken a routine screening sample before sending a kit. samples were received and hpv-analysis was performed. if the self-sample hpv test was negative, the woman was returned to the screening program according to routine practice. hpv-positive women were referred without triage for further investigation to a gynecologist responsible for the clinical follow-up of high-risk women. the gynecological examination included colposcopy as well as biopsies and a liquid based cytology (lbc) sample (analyzed for cytology and hpv), which are routine examinations in clinical practice according to national and international guidelines. colposcopies were performed within 3 months of a positive self-sample. if the colposcopic examination or the cytological/histopathological results indicated high-grade squamous intraepithelial lesions (hsil) or invasive cervical cancer, women underwent treatment by conization and/or hysterectomy according to national guidelines the cobas® pcr female swab sample packet was used for self-sampling, as previous studies had determined that the sensitivity for hpv was high and comparable with cervical samples used in the organized screening program. the hpv analysis was performed at the department of laboratory medicine, falun hospital using the cobas 4800 hpv test (roche molecular systems, south branchburg, new jersey, usa).

Eligibility criteria:
inclusion criteria: - women who had not participated in the organized screening program for at least 10 years exclusion criteria: - women who were hystrectomized, moved, died

Keywords: self sampling
mybehavior: persuasion by adapting to user behavior and user preference

Conditions: Weight Loss

Summary: mybehavior is a mobile application with a suggestion engine that learns a user's physical activity and dietary behavior, and provides finely-tuned personalized suggestions. to our knowledge, mybehavior is the first smartphone app to provide personalized health suggestions automatically, going beyond commonly used one-size-fits-all prescriptive approaches, or tailored interventions from health-care professionals. mybehavior uses an online multi-armed bandit model to automatically generate context-sensitive and personalized activity/food suggestions by learning the user's actual behavior. the app continually adapts its suggestions by exploiting the most frequent healthy behaviors, while sometimes exploring non-frequent behaviors, in order to maximize the user's chance of reaching a health goal (e.g. weight loss).

a dramatic rise in self-tracking applications for smartphones has occurred recently. rich user interfaces make manual logging of users' behavior easier and more pleasant; sensors make tracking effortless. to date, however, feedback technologies have been limited to providing counts or attractive visualization of tracked data. human experts (health coaches) have needed to interpret the data and tailor make customized recommendations. no automated recommendation systems like pandora, netflix or personalized search for the web have been available to translate self-tracked data into actionable suggestions that promote healthier lifestyle without needing to involve a human interventionist. mybehavior aims to fill this gap. it takes a deeper look into physical activity and dietary intake data and reveal patterns of both healthy and unhealthy behavior that could be leveraged for personalized feedback. based on common patterns from a user's life, suggestions are created that ask users to continue, change or avoid existing behaviors to achieve certain fitness goals. such an approach is different from existing literature in two important aspects: (1) suggestions are contextualized to a user's life and are built on existing user behaviors. as a result, users can act on these suggestions easily, with minimal effort and interruption to daily routines; (2) unique suggestions are created for each individual. this personalized approach differs from traditional one-size-fits-all or targeted intervention models where identical suggestions are applied for groups of similar people or the entire population.

Eligibility criteria:
inclusion criteria: * in relatively healthy condition. also, users must be interested in health and fitness. exclusion criteria: * individuals with physical disability and dietary problems are excluded.

Keywords: weight loss, fitness
effectiveness of a telephone intervention program in improving depression, coping, and family functioning in hiv-infected individuals and caregivers

Conditions: HIV Infections

Summary: this study will evaluate the effectiveness of the family intervention: telephone tracking (fitt) program in improving depression, coping, and family functioning in hiv-infected individuals and their caregivers.

individuals who are newly diagnosed with hiv often experience a variety of social and psychological problems, which can leave them depressed and unable to cope with their disease. the complex financial, legal, and psychiatric issues that many hiv-infected individuals must face can be stressful and can negatively affect their health; they may miss doctors' appointments or fail to adhere to a strict hiv medication regimen. the combination of stress and inconsistent medical care can affect the immune system and potentially worsen hiv symptoms. because of the multitude of stressors associated with hiv, hiv-infected individuals often rely on a network of family and friends for support; these caregivers, however, are often overwhelmed by their caregiver roles. they may experience helplessness, fear, and depression as a result of their added responsibilities. family intervention: telephone tracking (fitt) is a telephone-based intervention program that assists in identifying problems and resolving them through referrals to medical and community organizations that provide hiv-related support and services. it is also an educational resource that provides information on the many medical and psychological aspects of hiv infection. the main goal of fitt is to alleviate stress in both the hiv-infected individual and their support network by providing information and resources to help cope with hiv. the purpose of this study is to evaluate the effectiveness of fitt in improving family functioning, enhancing coping skills, and reducing depression in hiv-infected individuals and their caregivers. this 12-month study will enroll recently diagnosed hiv-infected individuals and one family member or friend who is identified as their primary caregiver. each pair will be randomly assigned to either the fitt intervention group or to an assessment-only group that will not receive fitt. individuals who are assigned to receive fitt will utilize the service for months 1 through 6. hiv-infected participants in both groups will also receive regular medical care throughout the study. outcome measurements will include self-assessments of depression, coping, and family functioning. in addition, participants receiving fitt will be asked to evaluate the effectiveness of the telephone intervention. all measurements will be assessed at baseline, and months 3, 6, and 12.

Eligibility criteria:
inclusion criteria: * recently began hiv care * currently undergoing hiv care in one of the brunap clinics * ability to co-enroll with a primary hiv informal caregiver * english- or spanish-speaking exclusion criteria: * schizophrenia * lacks regular access to a telephone to receive calls

Keywords: hiv telephone intervention
follow on study from re-align

Conditions: Thromboembolism; Heart Valve Prosthesis

Summary: to collect additional data relating to safety and indicators of efficacy for patients who have participated in the 1160.113 study.


Eligibility criteria:
inclusion criteria: 1. completed study 1160.113 per protocol 2. continuing need for anticoagulation exclusion criteria: 1. uncontrolled hypertension 2. severe renal impairment 3. active liver disease 4. increased risk of bleeding
tha kinematics and sound for subjects implanted using various surgical approaches

Conditions: Hip Injuries

Summary: in a previous study conducted within the center for musculoskeletal research (cmr) on total hip arthroplasties (tha), it was determined that the investigators could simultaneously capture in vivo sound and motion of the femoral head within the acetabular cup during weight-bearing activities for subjects implanted with either a metal-on-polyethylene (mop), metal-on-metal (mom) or ceramic-on-ceramic (coc) tha. this was the first study to apply sound analysis as an impulse excitation technique for testing hip conditions and for measuring femoral head sliding in the acetabular component of human hip joints by acoustic means. unfortunately, no studies have been conducted to compare the in vivo kinematics and sound for subjects implanted using various surgical approaches. it could be hypothesized that subjects having various surgical approaches could lead to an increase or reduction of in vivo hip separation. therefore, the objective of this study is to analyze a total of 30 subjects implanted with either an anterior (10 patients), anterior-lateral (10 patients), or posterior-lateral (10 patients) surgical approach to determine if any of these surgical approaches leads to less or more in vivo hip separation. all subjects will be analyzed under in vivo weight-bearing conditions using video fluoroscopy to determine in vivo motion.


Eligibility criteria:
inclusion criteria: * post-operative clinical evaluation judged successful using harris hip scoring (hhs) system (hhs\>90) * body weight less than 270 lbs * no evidence of post-operative hip subluxation or dislocation * do not walk with detectable limp * be able to actively abduct their operated hip against gravity without difficulty * must be willing to sign informed consent and health insurance portability and accountability (hipaa) forms exclusion criteria: * pregnant, lactating or females not using reliable form of birth control * patients that do not meet study requirements * patients unwilling to sign informed consent or hipaa forms

Keywords: surgical approach direct-anterior anterior-lateral posterior-lateral hip implant total hip arthroplasty total hip replacement hip replacement hip prosthesis