Kornimate/medical-research-clean huggingface dataset:
mediguide registry

Conditions: Heart Failure; Cardiac Arrhythmia

Summary: the goal of this registry/observational study is to collect data on the clinical utility of mediguide™ system in cardiac resynchronization therapy (crt) implantation and electrophysiology (ep) procedures.

the intent of this worldwide registry/observational study is to understand the utility of the mediguide™ technology in real world clinical practice during crt implantation and study-specific-ep procedures. the study should provide an understanding of the effect of mediguide™ technology on: * the amount of fluoroscopy time and the radiation exposure * total procedure time * peri-procedural clinical event rate additionally, this study will address the following * identification of procedural challenges which may aid in developing future mediguide tools * evaluation of newly available mediguide tools during the study * correlation between mediguide operator experience and the radiation exposure amount and time

Eligibility criteria:
inclusion criteria: * anybody coming for crt or ep procedure utilizing mediguide system and tools exclusion criteria: * none

Keywords: utility of mediguide system crt ep
early obesity intervention program within gecko drenthe; a randomized controlled trial

Conditions: Overweight; Physical Activity

Summary: the purpose of this study is to investigate whether stimulating physical activity during the first year of life influences growth and body composition, and stimulates motor activity and motor development


Eligibility criteria:
inclusion criteria: * date of birth (december 2006-february 2008) * area of living (around meppel and hoogeveen in the province of drenthe, one of the northern provinces of the netherlands) exclusion criteria: * children under care of child physiotherapists will be excluded from the program

Keywords: overweight physical activity infancy body composition motor development motor activity
direct and indirect impact of covid-19 in older populations

Conditions: Risk Factors for COVID-19 Outcomes in Elderly Populations

Summary: this study propose to describe risk factors for acute and long term mortality of covid 19 in patients up to 70 years old.

in december 2019, wuhan city in china, became the center of an outbreak of pneumonia due to a novel coronavirus sars-cov-2, which disease was named coronavirus disease 2019 (covid19) in february, 2020, by who. the covid19 is much more dangerous for people over 60 with a death rate of 3.6% after 60, 8.0% after 70 and 14.8% after 80 -and according to our italian colleagues over 20% after 90- against 2.3% in the general population. the elderly patients exhibits more complications (ards, delirium, cardiac and renal insufficiency) needing intensive care, and often had multiple comorbidities and in particular: cardiovascular disease (10.5% mortality), diabetes (7.3%), chronic respiratory disease (6.3%) and hypertension (6%). very few data are available the specific burden of infectious diseases (id) in older populations. the large majority of literature is often related to intrahospital or direct mortality and only recently arise the idea of indirect impact of id particularly in that populations. in that meaning, id may be considered as a trigger of other medical events such as myocardial infarction, stroke, or other specific outcomes such as functional decline; for the last 10 years, the specific interest group " ginger "( groupe infectio-geriatrique ) a network of infectiologist and geriatrician spilf/sfgg) carried out several studies on different aspects of id in theses populations and recently demonstrated the indirect and long term impact of influenza and clostridioides difficile infections. as an example, in influenza study, death-rate increases from 12,2 % in hospital related death to 25% at 3 months with high rate of complications (57%), high rates of rehospitalisation (25%) and functional decline (35%) leading to high increase in nursing home admission. the cost of these indirect impact is high and underestimated. because of incidence and comorbidities rates, severity of the actual french older covid 19-infected older populations and because of the potential indirect and long term impact of covid19 in these populations, it seems essential to know whether 3 month related death is largely higher as for influenza, to determine risk factors for intra hospital and long term death, measure acute and long term complications, and describe the impact of covid 19 on specific ageing outcomes such as functional status at month 3 (m3).

Eligibility criteria:
inclusion criteria: * + positive pcr confirmed covid 19 (confirmed case) or positive thoracic ct scan - (probable case) exclusion criteria: * direct admission in intensive care.

Keywords: elderly covid 19 mortality functional status
the diagnostic dilemma of anastomotic leak in esophagogastric surgery

Conditions: Anastomotic Leak

Summary: to study the diagnostic specificity and sensitivity of various modalities used for the assessment of anastomotic leak in esophagogastric surgery and to identify the most sensitive technique. secondarily, to propose a clinical algorithm to guide clinicians in the diagnosis of anastomotic leaks esophagogastric surgeries.

anastomotic leak in esophagogastric surgery remains a diagnostic challenge despite advances in imaging techniques. all available modalities appear to have limited sensitivities and have significant false negatives. a high index of clinical suspicion continues to be the key element in the early diagnosis of esophagogastric anastomotic leaks. the incidence of anastomotic leak in esophagogastric surgeries is reported to range from 7-20% in various studies, and it is a major complication that increases hospital stay and mortality. it is important to identify these complications early to optimize the outcomes of these patients. there has been no study till date that examines the incidence of false negative results for anastomotic leak in esophagogastric surgeries. false negative findings may give surgeons a false sense of assurance in the patient's postoperative recovery, and escalation of oral intake may result in catastrophic complications and outcomes in these patients. this study seeks to identify the most sensitive modality in the diagnosis of esophagogastric anastomotic leaks in a retrospective series of patients.

Eligibility criteria:
inclusion criteria: * patients undergoing any of the following surgeries at national university hospital, singapore between january 2001 and march 2019: * distal gastrectomies * total gastrectomies * bariatric gastric bypasses * subtotal esophagectomies * proximal gastrectomies * palliative bypasses * total esophagectomies exclusion criteria: * under 21 years of age

Keywords: anastomotic leak esophagogastric surgery bariatric surgery anastamosis
characteristics of glargine in type 2 diabetics

Conditions: Type 2 Diabetes

Summary: the study is to determine the dose response relationship of insulin glargine in type 2 diabetes over a 24-hour period and measuring the differences in glucose production among the differing doses of glargine. hypothesis: differing doses of insulin glargine over a 24-hour period in type 2 diabetes will show differing effects on endogenous glucose production, glucose disposal and carbohydrate and lipid flux.

the incidence of type 2 dm is increasing worldwide at an alarming rate. unfortunately, the number of individuals with glycemic control at or below the american diabetes association goal of 7% has dropped. in fact, the number of patients with their important cardiometabolic risk factors of glucose, lipids and blood pressure at goal is only 7%. one of the reasons for this lack of metabolic control in type 2 dm is the continued relative underutilization of insulin. diabetes is an insulin deficient state and requires appropriate physiologic replacement of insulin. physiologic replacement of insulin requires a basal component to restrain overnight endogenous glucose production, lipolysis and proteolysis. the other component involves prandial insulin to regulate post prandial glucose levels. recently, insulin glargine was introduced as a once-a-day peakless basal insulin. this form of basal insulin reproduces the normal constitutive physiologic release of insulin from the pancreas. insulin glargine represents a breakthrough in treatment as the previous available "basal insulins" either produced peaks of activity (which are disadvantageous as this results in hypoglycemia) or do not last 24 hrs which results in post absorbative hyperglycemia. despite the undoubted advantages of insulin glargine, there remains a lack of information regarding some aspects of glargine action. the study objectives are: 1) to determine the pharmacokinetic and pharmacodynamic dose response relationship of insulin glargine in type 2 dm; 2) partition the dose response relationship of insulin glargine on endogenous glucose production and glucose uptake in type 2 dm; and 3) to determine if the pharmacokinetic and pharmacodynamics of insulin glargine are consistent over a wide range of doses.

Eligibility criteria:
inclusion criteria: * 12 adults (males or females) with type 2 diabetes for at least six (6) months. may be using oral agents (sus, metformin, acarbose or glitinides) with or without insulin. * hgba1c 7 -12% * age 18-70 years * bmi 27-40 kg/m² exclusion criteria: * any past or present clinically relevant abnormality, medical condition, or circumstance making the subject unsuitable for participation in the study * evidence of hepatic, renal or cardiac failure * abnormal results following screening tests * pregnant or lactating females or females of childbearing potential who are unwilling to abstain from sexual intercourse or use reliable, medically accepted methods of contraception * currently using tzds * history of alcoholism or drug abuse within 12 months of the study

Keywords: type 2 diabetes insulin glargine endogenous glucose production
trunk balance and functional independence in individuals with sci

Conditions: Spinal Cord Injury (SCI)

Summary: this study investigates the relationship between trunk balance, position sense, wheelchair skills, and functional independence in individuals with thoracic spinal cord injury. it aims to understand how these factors interact and influence daily activities and overall quality of life.

sitting balance and wheelchair transfer activities are crucial for non-ambulatory spinal cord injury (sci) patients to be able to perform activities of daily living. in addition, a comprehensive assessment of trunk balance is recommended in the literature to predict the risk of falls in these patients and to determine their functional independence. however, no study was found in the literature that included only patients with thoracic level involvement in terms of parameters such as trunk balance, fall risk, postural control abilities, functional activity and independence, which are closely related to the level of injury in patients with sci. there is a need for a comprehensive evaluation of the patient in terms of trunk control and trunk balance, especially after a sci defined in the thoracic segment of the medulla spinalis. in this study, male and female individuals between the ages of 18-65 years with sci with thoracic level involvement who continue their routine treatment at the neurological rehabilitation unit of afyonkarahisar university of health sciences health application center department of physical therapy and rehabilitation will be included. the aim of the study is to examine the relationship between trunk balance, trunk position sense, wheelchair skills and functional independence status of the participants. the findings to be obtained after the study will be analyzed in patients with sci at the thoracic level.

Eligibility criteria:
inclusion criteria: * being diagnosed with traumatic or nontraumatic spinal cord injury, * having a thoracic injury level (t1-t12), * at least 6 months have passed since the sky injury, * to have 90 degrees of shoulder flexion and abduction in both upper extremities, * be over 18 years of age, * to be able to sit in a wheelchair without support and use a manual wheelchair independently, * volunteering to participate in the study. exclusion criteria: * having a systemic disease, * report a diagnosis of cardiovascular disease, * report musculoskeletal pain or pathology involving the upper extremity, * patients with intracardiac defibrillators, * presence of open wound.

Keywords: balance functional independence trunk position sense spinal cord injury wheelchair ability
pituitary adenoma and serum lipid

Conditions: Pituitary Adenoma 1, Acth-Secreting

Summary: pituitary adenomas are usually benign monoclonal neoplasms caused by a mixture of pituicyte alterations together with a changed endocrine and paracrine regulatory milieu. thus, it can cause serious health problems such as abnormal target organ function, pain, disability and even death. in clinical practice, we found many patients with pituitary adenomas are usually accompanied by hyperlipidemia, which is the main cause of cardiovascular diseases. however, it has been unclear if there is an association between pituitary adenomas and serum lipid profile. in the present study, we aim to focus on the patients with pituitary adenomas and their lipid profile before and after operation including first occurrence and recurrence.


Eligibility criteria:
inclusion criteria: 1. patients diagnosed with pituitary adenomas 2. all adenomas were resected by transsphenoidal surgery and identified by histological diagnoses. exclusion criteria: 1. missing vital data, such as age, gender, serum lipid profile, pathology reports; 2. complications or conditions that affect pituitary status and lipid metabolism, such as pregnancy, malignant adenomas or severe hepatic or renal dysfunction and 3. use of any medication that affects the pituitary or lipid metabolism, including statins, fibrates, thyroid hormones, anti-thyroid drugs, iodine, amiodarone, alemtuzumab, lithium, tyrosine kinase inhibitors, interferon, estrogens, androgens,glucocorticoids, nonsteroidal anti-inflammatory drugs, antiepileptic drugs, rifampicin, furosemide, heparin or β-adrenoceptor blockers in the past 3 months.

Keywords: pituitary pituitary adenoma serum lipid levels resection recurrence
safety and efficacy of single administration of oshadi oral insulin in type i diabetes patients

Conditions: Diabetes

Summary: the study will be a non-randomized, open label, single dose, single blind, placebo control, single center, single arm study in type i diabetes patients. the study will include single dose administration for the evaluation of single dose acute toxicity, pharmacokinetics and activity.


Eligibility criteria:
inclusion criteria: * stable type i diabetes mellitus. * male/female 18 years old and up. * glucose level is treated only by s.c basal/bolus insulin injection (not by insulin pump) at least 48 hours prior to study initiation. * patients must understand and be willing to give written informed consent prior to any study procedures or evaluations and be willing to adhere to all study schedules and requirements. * patients must be sterile or infertile or use an approved method of contraception from the time that the first dose of study medication is taken until three months following study completion or discontinuation. exclusion criteria: * any history of significant cardiac, renal, neurologic, metabolic, pulmonary, gastrointestinal, hematologic abnormality, chronic hepatic disease or any other disease which in the judgment of the investigator would interfere with the study or confound the results. * patients with positive hiv serology or positive hbsag at screening. * history or evidence of any active liver disease. * c-peptide \> 3 mg/ml (fasting). * hba1c\<10. * egfr\>60. * female patients who are breastfeeding or have a positive pregnancy test at screening or at any time during the study. * inability to give written informed consent. * history of alcohol or drug abuse within 6 months of screening. * patients who have a positive urine drug screen for substances of abuse (benzodiazepine, thc, opiates, amphetamines, cocaine) at the screening. * mental disorders. * patients with poor venous access. * significant swallowing disorders. * digestive disorders. * small bowel surgery. * mall absorption disorders.

Keywords: oral insulin
zometa study in pediatric acute lymphoblastic leukemia

Conditions: Osteoporosis

Summary: acute lymphoblastic leukemia (all) is the most common malignancy in children. it accounts for one fourth of all childhood cancers \& 74 % of childhood leukemia. based upon drug registry data, children prescribed more than three courses of systemic glucocorticoids yearly faced a 20% increase in age-adjusted fracture rates. rapid recovery occurred once glucocorticoids were discontinued, and fracture rates returned to expected for age by 1 year after treatment (journal of clinical endocrinology \& metabolism 2009). the investigators will study the role of bisphosphonates in the prevention of secondary osteoporosis in children \& adolescents treated for all in the children's cancer hospital -egypt.


Eligibility criteria:
inclusion criteria: * age above 5 \& below 18 years at the time of diagnosis. * newly diagnosed all patients. * not previously treated, previous steroid intake not more than 72 hours. * treated according to st judy study xv protocol. exclusion criteria: * previous steroid intake more than 72 hours. * less than 5 years

Keywords: all zoledronic acid osteoporosis
condor temporomandibular muscle and joint disorders (tmjd) survey

Conditions: Temporomandibular Disorders

Summary: the purpose of study was to characterize using an online questionnaire the feasibility of recruiting dentists in primary care dental practices in the practice-based research network and documenting their current initial care for their tmjd pain patients.

the overall goal of this project was to collect data to be used in preparing an application for a clinical trial planning grant and then in designing a subsequent phase iii clinical trial. the ultimate goal of this series of research projects is to determine the most practical approach to conduct a randomized clinical trial (rct) to evaluate initial intervention for patients with painful temporomandibular muscle and joint disorders (tmjd) using nidcr's collaboration of networked dental and oral health research (condor) group consisting of three dental practice-based research networks: the dental practice-based research network (dpbnr), northwest practice-based research collaborative in evidence-based dentistry (precedent), and practitioners engaged in applied research and learning (pearl).

Eligibility criteria:
inclusion criteria: * dpbrn dentist practitioner-investigator (general dentists or specialists) who had completed a dpbrn enrollment questionnaire * 22 years of age or older

Keywords: tmjd pain feasibility
role of doxycycline in chronic rhinosinusitis with nasal polyps

Conditions: Nasal Polyps; Chronic Rhinosinusitis With Nasal Polyps

Summary: to evaluate the efficacy of doxycycline as an adjunct to systemic steroids in the treatment of chronic rhinosinusitis with nasal polyps

chronic rhinosinusitis with nasal polyps (crswnp) is a disease of the nose and paranasal sinuses characterized by mucosal thickening and polyp formation. the prevalence of crswnp in the general population ranges between 1 and 4%. it mostly affects adult individuals. the treatment of crswnp can include the use of steroids, antibiotics, saline nasal spray, mucolytics, topical/systemic decongestants, topical anticholinergics, anti-leukotrienes or receptor blockers, and antihistamines. steroids have a multitude of effects, including inhibition of cytokine synthesis, reduction of the number of eosinophils and activated eosinophils, anti-oedema effects and reduction of transudation. topical corticosteroid therapy is not effective in all patients, leading to the use of systemic glucocorticosteroids and/or sinus surgery to control the disease. as a new approach, antibiotics are being used to treat crswnp particularly in patients with disease exacerbated by the staphylococcus aureus enterotoxin. antibiotics with anti- inflammatory effects can be used to treat patients with chronic rhinosinusitis without polyps, which might be the precursor to crswnp. long-term treatment with these drugs, in selected cases, may be effective when corticosteroids fail. doxycycline has dual action: it has well described, broad-spectrum antibacterial activity against s aureus as well as anti-inflammatory properties. it appears to be effective in treatment of several chronic inflammatory airway diseases.

Eligibility criteria:
inclusion criteria: 1- adult patients (aged 18 and over) with bilateral nasal polyps confirmed by nasal endoscopy and ct scan. exclusion criteria: 1. crs without nasal polyps. 2. unilateral nasal polyps. 3. pregnant and lactating women. 4. patients younger than 18 years old. 5. subjects with known allergic reaction to steroids or tetracyclines, hypertension, diabetes (type 1 and 2), glaucoma, tuberculosis, herpes infection are excluded. 6. if any major complications to the drugs in use appeared in process.
effects of different i:e ratio on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position

Conditions: Lung Cancer; Lung Lobectomy

Summary: the purpose of this study is to investigate effect of increasing inspiratory time (i:e ratio 1:1) on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position.

increasing inspiratory time(e.g. inverse ratio ventilation) has been known that had advantage of alveolar recruitment, preventing of ateletasis. on the contrary, it has disadvantange of intrinsic peep, air trapping. there is few study on one lung ventilation in lateral decubitus position about this ventilation method. we were going to investigate effecf of this ventilation method.

Eligibility criteria:
inclusion criteria: * asa physical status class i, ii * use of double lumen tube * unilateral lung lobectomy exclusion criteria: * copd * caod * unstable hemodynamic status * peak airway pressure \> 30mmhg (two lung ventilation)