Kornimate/medical-research-clean huggingface dataset:
acupressure and stress resilience

Conditions: Post-traumatic Stress Disorder (PTSD); Mild Traumatic Brain Injury (mTBI)

Summary: the current study will assess the efficacy of acupressure, a type of complementary and alternative medicine (cam) in the veteran population. veterans with co-occurring mild traumatic brain injury (mtbi) and post-traumatic stress disorder (ptsd) will be consented and randomly assigned to either an active or placebo acupressure treatment series of 8 sessions. the investigators will determine if acupressure affects aspects of day-to-day function, such as memory, sleep, mood, psychiatric health and stress resilience. this information will help identify potential treatment strategies to improve quality of life and overall function in this particular veteran population.


Eligibility criteria:
inclusion criteria: * between the ages of 18-60 * diagnosis of mild tbi and ptsd as assessed by interview and/or chart review * currently receiving or eligible to receive physical and/or mental healthcare through the va eastern colorado health care system exclusion criteria: * history of other significant neurological disease (e.g., alzheimer's, parkinson's, multiple sclerosis etc.) as assessed by interview and/or chart review. such conditions could affect outcome measures independently, thereby creating an experimental confound. * history or diagnosis of lifetime moderate to severe tbi, as assessed by interview and/or chart review. * history of psychotic disorder or bipolar i disorder as assessed by structured interview. such conditions could affect outcome measures independently, thereby creating an experimental confound. * inability to read the informed consent document or adequately respond to questions regarding the informed consent procedure. * prior experience with acupressure, as this would result in individuals potentially being able to detect placebo treatments if randomly assigned to that group.
acupuncture in mothers of very low birth weight infants

Conditions: Anxiety

Summary: does ear acupuncture reduce anxiety in mother of very low birth weight infants?


Eligibility criteria:
inclusion criteria: * can read and write in portuguese exclusion criteria: * breastfeeding contraindication * use of lactogogues

Keywords: acupuncture anxiety human milk very low birth weight infants mother of very low birth weight infants
tms electrochemotherapy for glioblastoma multiforme

Conditions: Glioblastoma

Summary: the proposed project aims to develop novel electrochemotherapeutic treatment of glioblastoma multiforme (gbm). standard treatment has limited effect on survival and quality of life. electrochemotherapy is a novel and promising treatment, which has demonstrated convincing results in the treatment of various types of carcinoma. the treatment is based on a combination of electrical current stimulation of tumor cells and simultaneous administration of chemotherapeutic drugs. electrochemotherapy works by inducing an electrical current between implanted electrodes in the tumor tissue, causing electroporation of the cancer cell membranes, and thereby increasing the cellular permeability and drug uptake. electrochemotherapy has proven to be an efficient way of considerably increasing the potency of the chemotherapeutic drug bleomycin in malignant cells in skin tumors and carcinoma metastases, and thereby increasing cytotoxicity of the drug locally in the tumor tissue. this allows for treatment with lower doses of chemotherapeutic drugs and more defined, local area of effect, thus decreasing systemic effects. the investigators propose to use a novel non-invasive and safe technique called focused transcranial magnetic stimulation (focused tms) to induce electrical current in the tumor tissue. tms is a safe and widely implemented technology used to treat multiple neurological diseases such as pain, depression and stroke. studies have shown that effective electroporation of cell membranes can be obtained using induction of electromagnetic fields in a cell suspension, and new focused tms further enables focused treatment of selected brain regions without surgical intervention and, thereby focusing chemotherapeutic treatment to pathological tissue and avoiding surgery related brain tissue damage. additionally, tms transiently increases blood-brain barrier permeability, theoretically allowing increased uptake of chemotherapeutic drugs in the target area. this addresses a significant challenge in the treatment of brain cancer, as most cytotoxic drugs have fairly limited ability to pass the blood brain barrier. the intention of this research project is to investigate the therapeutic potential of focused tms as an alternative non-invasive source of current induction and thereby means to treat several types of brain cancer with electrochemotherapy.


Eligibility criteria:
inclusion criteria: * newly diagnosed and histologically confirmed glioblastoma multiform * mgmt gene methylation * if age \< 70, eligibility to comply with the stupp radio chemotherapy regimen * if age \> 70, eligibility for stand alone chemotherapeutic treatment * ability to comply with the proposed tms treatment * use of validated anti-conception for fertile female participants in concordance with guidelines provided by the danish health and medicines authority exclusion criteria: * pregnancy or nursing * other conditions that may contraindicate the use of transcranial magnetic stimulation * implanted pacemaker or metal contraindicating mri-scan
clinical trial on patient-specific-instrumentation assisted lapidus fusion for hallux valgus

Conditions: Hallux Valgus; Bunion; Patient Spe

Summary: rct to compare the effectiveness of psi assisted lapidus surgery vs conventional lapidus surgery in hallux valgus.

hallux valgus (hv) affects up to 30% of the population. lapidus surgery, a combination of 1st tarsal-metatarsal joint arthrodesis is one of the most common surgical options for hv. despite its popularity, the current method alone is not without complications. this will be the world's first lapidus arthrodesis surgery utilising patient-specific instruments (psi) as an assistive tool. we hypothesise that psi will enhance surgical precision, accelerate fusion rates, decrease non-unions, and reduce the need to use bone grafts. methods and analysis: this is a single-blinded, parallel-group, randomised controlled trial comparing the outcome of the 3d-printed psi assisted lapidus fusion (n=27) vs conventional lapidus fusion (n=27) for hv deformity. both groups will receive indentical post-operative rehabilitation of protected weight bearing and splinting. outcomes measured will include foot function scores, radiological alignment and arthrodesis site assessment with x-ray and high-resolution peripheral quantitative-computed tomography, and foot pressure analysis.

Eligibility criteria:
inclusion criteria: * symptomatic hallux valgus * hallux valgus angle \>20 * 1,2 inter-metatarsal angle \>9 exclusion criteria: individuals with (1) disabilities (both physical and mental) which may impair the adherence of the rehabilitation, (2) revision hv surgery, (3) concomitantly undergone additional procedures on the same foot (e.g. claw toe surgery), (4) the use of medications that may influence bone turnover (e.g. chemotherapy, osteoporotic medications) in recent 3 months, (5) medical comorbidity leading to contraindication for surgery, (6) the inability to understand written chinese/english, (7) who are mentally/physically unable to consent will be excluded.
designing multimedia patient education for adolescent idiopathic scoliosis

Conditions: Adolescent Idiopathic Scoliosis; Patient Engagement

Summary: the goal of this triple-masked three-armed feasibility randomised controlled trial is to compare patient education materials for participants with adolescent idiopathic scoliosis. the main question it aims to answer are: * are educational videos superior to usual care? * are educational videos formatted in line with literature advice on multimedia design superior to videos formatted as traditionally found on scoliosis advisory websites participants in the video groups will be asked to do view six educational videos and respond to a quiz. researchers will compare the informed video group and traditional video group to usual care to see if there are differences in engagement, quality of life, physical activity and health-related anxiety.

multimedia patient education materials are increasingly used in healthcare. this triple-masked three-armed feasibility randomised controlled trial will examine participants aged 10-18 with radiographically confirmed adolescent idiopathic scoliosis and their response to usual care or to receive multimedia educational videos with or without evidence-informed design principles. primary outcomes will be patient knowledge measured by online quiz and engagement measured by youtube analytics. participants will be masked in the two video intervention arms, as will the therapist sending the educational videos. the results will outline the number of participants recruited and randomised, the number analysed post-intervention and at week eight, and the outcomes for baseline, post-intervention and week 8, which will include the effect size and level of precision. adverse events will also be reported. this feasibility randomised controlled trial will offer insight into the effectiveness of implementing advice from the literature in designing multimedia patient education materials for a population with adolescent idiopathic scoliosis.

Eligibility criteria:
inclusion criteria: * aged 10-18 years * parent/guardian consent for those under 18 years of age * adolescent idiopathic scoliosis (ais) as confirmed by cobb angle ≥10deg on plain film radiographs * able to watch and listen to online educational materials as well as read and complete online surveys exclusion criteria: - scoliosis due to non-ais conditions

Keywords: scoliosis multimedia patient education health education adolescent idiopathic scoliosis
the association between ovarian endometrioma and lower urinary tract symptoms

Conditions: Ovarian Endometrioma

Summary: to assess the relationship between ovarian endometrioma and lower urinary tract symptoms, sexual function and gastrointestinal symptoms. in addition, the investigators also assess the impact of surgeries for ovarian endometrioma on lower urinary tract symptoms, sexual function and gastrointestinal symptoms.

all patients were found to have ovarian endometrioma were invited to participate in this study. the size and location of ovarian endometrioma should be assessed by ultrasonography. besides, all enrolled female patients will be asked to complete overactive bladder symptom score, female bladder function, female sexual function, and bowel incontinence assessment questionnaires and ca125 level. in addition, patients who underwent surgeries for ovarian endometrioma will be requested to complete the above questionnaires and ca125 check-up at 3 \& 6 months after surgery. at least 30 women with age and body mass index matched and without ovarian endometrioma will be invited to participate in this study as the control group.

Eligibility criteria:
inclusion criteria: 1. \>20 years old. 2. ovarian endometrioma: women having a frosted glass content in ovarian cyst exclusion criteria: 1. the patient is acute lower urinary tract infection or intestinal inflammation. 2. had received surgery bladder or urethra. 3. patients with a history of urinary tract stones or tumors.

Keywords: ovarian endometrioma lower urinary tract symptoms sexual dysfunction gastrointestinal symptoms
diagnostic value of next-generation sequencing analysis in biliary tract tumours

Conditions: Hepatectomy; NGS; Stenosis of Bile Duct

Summary: the aim of this study is to identify a dysplasia- and cca-specific ngs panel to increase the diagnostic sensitivity of histological and/or cytological examination of biliary tract stenosis.

patients undergoing biliary tract resection, as part of the normal course of care, at the o.u. general surgery and transplantation will be enrolled. tissue samples will be processed and analysed at the o.u. of pathological anatomy. clinical, serological and instrumental data from patients, considered necessary for the intended analyses, will be collected for the purposes of the study. the study will have a total duration of 36 months. it is planned to enrol 50 patients, all belonging to the u.o. hepatobiliary and transplant surgery of the irccs azienda ospedaliero-universitaria di bologna. the size of the population is estimated on the basis of the number of cases/year from the u.o. hepatobiliary and transplant surgery, and is considered sufficient to achieve the primary objective, since it is an exploratory study. surgical material (resection of biliary tract, possibly hepatectomy or duodenocephalopancreasectomy), which will be sampled according to clinical practice and sent to the o.u. of pathological anatomy of the irccs aoubo, where it will be sampled, fixed in formalin, included in paraffin and processed. from paraffin blocks (selected from those obtained from the sampling of surgical pieces according to clinical practice) 2 µm sections will be cut for next generation sequencing investigations.

Eligibility criteria:
inclusion criteria: * availability of enough tissue for histological and ngs analysis (at least 20 ng dna). * age greater than/equal to 18 years. exclusion criteria: * none

Keywords: next generation sequencing stenosis of bile duct
tens for limb function in stroke: design and rationale for a randomized trial

Conditions: Stroke

Summary: this study tests whether slow or fast electrical nerve stimulation (tens) works better to improve arm movement in people recovering from a stroke. participants will receive tens on their weak arm three times a week for eight weeks. the results will help find the best tens setting to support stroke recovery.


Eligibility criteria:
inclusion criteria: 1. age 18 to 85 years 2. clinical diagnosis of stroke (ischemic or hemorrhagic) within the past 10 days to 2 months 3. presence of voluntary movement in the non-paretic arm and at least minimal antigravity movement in the paretic shoulder 4. at least 5 degrees of active wrist extension on the paretic side 5. able to provide informed consent exclusion criteria: 1. uncontrolled medical, cardiovascular, or orthopedic conditions 2. contraindications to tens (e.g., implanted cardiac pacemaker, skin allergies) 3. receptive aphasia preventing informed consent or cooperation 4. significant peripheral neuropathy affecting upper limbs 5. current participation in another clinical trial or drug study 6. severe contractures in the shoulder, elbow, wrist, or fingers
a novel combination of peripheral nerve blocks for patients scheduled for shoulder surgery

Conditions: Pain

Summary: interscalene block has been the traditional regional anesthesia for shoulder surgery and postoperative pain. however, the risk of phrenic nerve palsy and irreversible nerve injury have encouraged search for alternative methods.

analyzing block effects of the lateral sagittal infraclavicular brachial plexus block(posterior and lateral chord), the investigators found it affecting all shoulder relevant nerves , except for the suprascapular and the supraclavicular nerves. accordingly, by combining a superficial cervical plexus block, suprascapular nerve block and block of the posterior and lateral chords infraclavicularly, the investigators believe this novel combination would provide anesthesia for patients scheduled for shoulder surgery.

Eligibility criteria:
inclusion criteria: * patients scheduled for shoulder surgery. * american society of anesthesiologist grad i-iii, * 18-70 years, * bmi 20-35, exclusion criteria: * pregnancy, * coagulopathy, * allergy to local anesthetics, * atrioventricular block, * peripheral neuropathy or drug-treated diabetes. * patients using anticoagulation other than acetylsalicylic acid or dipyridamol will be excluded.
community-based swallowing training for elderly individuals: impact and benefits

Conditions: Dysphagia

Summary: the goal of this clinical trial is to explore the impact of systematic simple swallowing training on swallowing function and quality of life in community-dwelling elderly individuals (≥60 year old) with swallowing disorders. it primarily aims to address two key aspects: 1) the prevalence of dysphagia among community-dwelling elderly individuals, and 2) the effects of systematic simple swallowing training on swallowing function and quality of life in community-dwelling elderly individuals with swallowing disorders. all participants are required to undergo a continuous three-week (21 days) systematic simple swallowing training, with weekends off and training conducted only on weekdays. the training will be conducted two sessions per day, lasting 15-30 minutes each.

the investigators have designed a simple and user-friendly swallowing rehabilitation training method called "systematic simple swallowing training" based on commonly used swallowing training techniques in the department of rehabilitation medicine and the prevalent pathological causes of swallowing disorders in the elderly. it has shown promising preliminary efficacy. however, before we can promote its widespread adoption, a series of studies must be conducted to establish its effectiveness. the goal of this clinical trial is to explore the impact of systematic simple swallowing training on swallowing function and quality of life in community-dwelling elderly individuals (≥60 year old) with swallowing disorders. it primarily aims to address two key aspects: 1) the prevalence of dysphagia among community-dwelling elderly individuals, and 2) the effects of systematic simple swallowing training on swallowing function and quality of life in community-dwelling elderly individuals with swallowing disorders. all participants are required to undergo a continuous three-week (21 days) systematic simple swallowing training, with weekends off and training conducted only on weekdays. the training will be conducted two sessions per day, lasting 15-30 minutes each.

Eligibility criteria:
inclusion criteria: * age over 60 years old. * no hospitalization within the past six months. * with clear consciousness and able to cooperate with questionnaires and training. * the elderly people who voluntarily participate and agree to adhere until the end of the study. exclusion criteria: * complicated with severe liver and kidney failure, tumors, or hematological disorders. * physical disability. * difficulty in mobility.
teleneuro-rehabilitation systems for neurodegenerative conditions: the fit4teleneuro pragmatic trial

Conditions: Parkinson Disease; Multiple Sclerosis; Neurologic Diseases, General

Summary: the goal of the fit4teleneuro pragmatic trial is to verify, in real-life care contexts, the superiority in terms of the effectiveness of early rehabilitation intervention with telerehabilitation (tr) protocols (tr single approach, task-oriented - trsa; tr combined approach, task-oriented and impairment-oriented - trca) compared to conventional management (educational treatment, et). the main questions it aims to answer are: * are telerehabilitation protocols more effective than educational treatment? * is the trca treatment more effective than the trsa? the study investigates the effects of rehabilitation treatment by comparing the two target cases (multiple sclerosis - ms and parkinson's diseases - pd). participants will be subjective to: * 3 time-point of assessment (baseline, post-treatment and follow up) with motor, cognitive and quality-of-life measures * a 5-weeks rehabilitation treatment (4 times/week)


Eligibility criteria:
inclusion criteria: * diagnosis of probable pd according to mds criteria (postuma et al., 2015) in staging between 1 and 3 on the hoehn \& yahr scale (goetz et al., 2004) or diagnosis of ms according to the criteria of mc donald 2010 (polman et al., 2011) with disability level at the expanded disability status scale edss (kurtzke, 1983) ≤ 4.5; * age between 25 and 85 years; * preserved cognitive level at the montreal cognitive assessment test (moca test \>15.5) (santangelo et al., 2015); * no rehabilitation program in place at the time of enrolment; * stable drug treatment (last three month) with l-dopa or dopamine agonists (pd group) or disease modifying therapies (dmts) (ms group). exclusion criteria: * presence of comorbidities that might prevent patients from undertaking a safe home program or determining clinical instability (i.e., severe orthopedic or severe cognitive deficits); * presence of major psychiatric complications or personality disorders; * presence of severe impairment of visual and/or acoustic perception; * falls resulting in injuries or more than 2 falls in the 6 months prior to recruitment (pd and ms groups). * pregnancy * relapse ongoing/at least 3 months since the last relapse (ms group); * presence of "frequent" freezing as recorded at the administration of section ii (daily life activity) of the updrs (score ≥ 3) (pd group); * edss-fs (cerebellar function) ≥ 3 (ms group).

Keywords: telerehabilitation digital medicine chronic neurological diseases rehabilitation telemedicine parkinson&#39;s disease multiple sclerosis ehealth
cardiac and pulmonary assessment in egyptian patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: to determine cardiac and pulmonary involvement in ra patients to assess the correlation between cardiopulmonary findings in ra patients with disease activity. to compare between diaphragmatic ultrasonography and pft i.e. spirometry as a screening tool for restrictive pulmonary disorders. to assess correlation between anterior chest wall ultrasound and pulmonary function test in ra patients.

rheumatoid arthritis (ra) is a chronic inﬂammatory autoimmune disease with systemic manifestations targeting primarily synovial joints and periarticular tissues, with a 1-3% prevalence, it is the most prevalent form of inflammatory arthritis.(1,2) although synovitis is the pathological hallmark of ra, numerous extra-articular symptoms and comorbidities are probably present.(3) cardiovascular and pulmonary system diseases are the two main causes of death in ra patients, and their symptoms are the most serious.(2,3) patients with ra have a 50% greater risk of cv mortality and a two-fold increased risk of myocardial infarction, which is the most common cause of death in this population. (4) echocardiographic examination is considered a good predictive tool for some cardiac conditions with early findings while no clinical signs is yet found on these patients. (5) the second major cause of death in patients with ra is respiratory disease, which occurs in 30-40% of patients.(6) sometimes the disease is silent until it has lung complications, which come before joint problems. ra may affect the lung interstitium, airways, and pleurae, while pulmonary vascular involvement is less frequent.(7) diaphragmatic ultrasound can be used to determine the prevalence of interstitial lung disease involvement in ra as a restrictive disorder. the association between pulmonary function tests (pfts), potential risk factors, and clinical correlation must be calculated.(8)(9) anterior chest wall (acw ) joints undergo joint changes and can be involved along the course of ra yet seems to be underestimated(1) ultrasonography of acw can detect those changes even before being clinically evident (10)

Eligibility criteria:
inclusion criteria: * any patient satisfying 2010 acr/ eular ra classification criteria exclusion criteria: * patients with definite diagnosis for any other systemic autoimmune disorders

Keywords: cardiac pulmonary rheumatoid arthritis