Kornimate/medical-research-clean huggingface dataset:
endoscopic evaluation for predicting the complications related to gastric conduit after esophagectomy

Conditions: Esophageal Neoplasms; Constriction; Anastomotic Leak; Ischemia

Summary: gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures. thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. the investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.

the development and improvement of thoracoscopic esophagectomy (te) reduced the severe pulmonary complication after esophagectomy. however, the postoperative complications relative to gastric conduit reconstruction are still common issues after esophagectomy. the ischemia of the proximal portion of the graft predisposes these patients to a high incidence of anastomotic complications after esophagectomy. less commonly, severe graft ischemia can lead to transmural necrosis. thus, early diagnosis of ischemic reaction may provide the suitable postoperative management and therapeutic intervention to prevent leakage, strictures and necrosis. thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. the investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.

Eligibility criteria:
inclusion criteria: - malignant or end-stage benign esophageal disease. esophagectomy with reconstruction by a gastric pull-up. exclusion criteria: - severe heart failure and pulmonary dysfunction severe renal and liver dysfunction allergenic history pregnancy
the bone metabolism characteristics of premature ovarian insufficiency

Conditions: Premature Ovarian Insufficiency; Bone Diseases, Metabolic; Bone Mineral Density

Summary: explore the bone metabolism characteristics of premature ovarian insufficiency.

explore the bone metabolism characteristics of premature ovarian insufficiency, indexes includes serum levels of tracp-5b and balp, bmd values of lumbar spine l1-l4, left and right hip, left and right femoral neck et.al.

Eligibility criteria:
inclusion criteria: patients diagnosed by western medicine with premature ovarian insufficiency. 18 ≤ patients' age ≤ 39 years;. patients who voluntarily participate in this study, sign an informed consent form. exclusion criteria: patients with congenital gonadal dysplasia or a family history similar to "early menopause". poi patients with acquired organic lesions or ovarian surgery. patients who have taken western or herbal medicine artificial cycle therapy or other endocrine therapy in the past three months. patients with serious primary diseases and mental disorders such as cardiovascular and cerebrovascular, liver, kidney and hematopoietic system. patients who are breastfeeding or pregnant.
ear acupuncture effectiveness in reducing the signs and symptoms of stress and anxiety

Conditions: Inclusion Criteria:; Voluntary Participation in the Study With Available Time for Submission to the Sessions, Which Occur Over Two Months.; Have a Score of Stress Medium, High or Very High in the LSS Questionnaire, Completion of the STAI and General Form.; Exclusion Criteria:; Pregnant Students.

Summary: randomized controlled trial found that levels of stress and anxiety of students itio, ear and effective in reducing these levels. the lss questionnaire and idate state were applied before, two months and two and a half months after the start of the applications, the stai trait was applied once prior to the sessions. the sample comprised 56 individuals who had higher levels of stress above the average lss 100 students who answered the questionnaires. participants were divided randomly into three groups: control group with 15 patients without care, intervention group with 20 individuals using specific points for treatment and group sham at 21 points using individuals without indication for treatment of anxiety and stress. the results showed that the sham points decreased anxiety levels of participants.

after checking the levels of stress and anxiety of students and workers from a school of massage and acupuncture concluded that auricular acupuncture in this study had significant results in reducing anxiety levels with the use of points and ear handle, but more studies are necessary so that it can be said that these points have sedating and calming effects for anxiety.

Eligibility criteria:
inclusion criteria: * voluntary participation in the study with available time for submission to the sessions, which occur over two months. * have a score of stress medium, high or very high in the lss questionnaire, completion of the stai and general form. exclusion criteria: * pregnant students. the only contraindication to this treatment is for pregnant women until the 3rd month of pregnancy
awareness and knowledge of the surgical safety checklist among operational staff in university teaching hospital, kathmandu, nepal: a cross-sectional questionnaire

Conditions: Surgical Checklist

Summary: the introduction of the world health organization surgical safety checklist (who ssc) is a priority to promote surgical safety. however, little is known regarding awareness and knowledge of the who ssc in developing countries. this study aimed to obtain region-specific information for the introduction of the checklist in a core medical institution in nepal. the present research was a cross-sectional study using data from a survey conducted at the tribhuvan university teaching hospital (tuth) in kathmandu, nepal. a questionnaire was distributed to 150 healthcare professionals working in the operating theatre. responses to the questionnaire were analysed descriptively and regression analyses identified factors associated with awareness of the checklist.


Eligibility criteria:
inclusion criteria: * have optimal experience exclusion criteria: * less experience
quantifying viral load in respiratory particles that are generated by children and adults with covid-19 infection

Conditions: COVID-19

Summary: the study will be a prospective cohort design to determine if children generate aerosols that harbor a viral load similar to adults. prior to beginning enrollment, researchers may recruit up to 10 participants (adults or children who meet inclusion criteria for the main study) to perform a small pilot to optimize our cold chain and laboratory procedures. the study will include children and adults who are confirmed sars-cov-2 positive and aim for a total sample size of at least 10 children and 10 adults. hypothesis: as children have a high viral load in the nasopharynx, we hypothesize that children generate aerosols that contain sars-cov-2 virus. aim: to estimate the viral load in aerosols generated from children with covid-19 infection, and to compare the viral load contained in aerosols from children with aerosols from adults

for children and adults who are admitted to mgh, study staff will perform: step 1: a nasal and oral swab will be obtained to establish the nasopharyngeal viral load. step 2: study staff will use the cci and/or upas to collect aerosol samples for viral load. staff will sample the room aerosol for 30 minutes while the participant does not wear a mask, and then if the participant is interested, staff will sample room aerosol while the participant wears different types of masks. if the participant does not tolerate wearing a surgical mask, or if the providers believe this is contraindicated, researchers will forego this portion of the study procedures. if an accompanying family member chooses to stay in the patient room during testing, they will be provided with an n95 respirator. step 3: staff will ask participants to repeat these steps and provide a sample each day that they are having symptoms of covid-19. the study may conduct serial sampling, where participants could be asked to provide a sample each day that they are having symptoms of covid-19 up until discharge, or once symptoms resolve. once symptoms resolve or the patient is discharged, sampling will be complete.

Eligibility criteria:
inclusion criteria: * sars-cov-2 pcr positive in the last fourteen days * symptomatic with typical symptoms of covid-19, including fever, cough, nasal congestion, rhinorrhea, anosmia, ageusia, shortness of breath, chest pain, fatigue, myalgias, or other atypical symptoms with documentation of that symptom or * asymptomatic with laboratory confirmation of cycle threshold value \< 30. exclusion criteria: * chronic respiratory disease or neuromuscular condition associated with severely reduced lung function defined as fev1 or fvc \<50% predicted, or requiring chronic supplemental oxygen or respiratory support * on current respiratory support via supplemental oxygen, non-invasive ventilation, or invasive mechanical ventilation

Keywords: covid-19 viral load
enhancing referral decision-making for advanced treatment in parkinson's disease through objective measurements and patient reported outcomes.

Conditions: Parkinson Disease

Summary: the overall aim of the trial is to compare the efficacy of using wearables and patient-reported outcome measures versus standard care in enhancing the timeliness of referrals to advanced monitoring of treatments for people with parkinson's disease.

the study is a multicentre, parallel group, randomized controlled trial, investigating the value of using wearable devices and electronic patient-reported outcome measurements to improve clinical decision-making related to people with parkinson's disease. data from a wearable device and a mobile app will be compared to current standard of care. 90 participants will be recruited from the uptake area of the movement disorder clinics (mdc) at rigshospitalet glostrup (rhg) and odense university hospital (ouh), as well as from 5 private practice neurologists in denmark. they will equally be randomized to one of two groups: intervention or standard of care. each participant will take part of the trial for one year, in which they will have 5 study visits: * baseline * clinical visits every 3 months (months 3, 6 and 9) * final visit after 12 months they will be asked to wear the device and report symptoms in the app for one year. we will then compare decisions made related to changes in medication and referrals to advanced treatment.

Eligibility criteria:
inclusion criteria: * diagnosed with idiopathic parkinson's disease * taking five or more doses of levodopa daily * experiencing fluctuations in motor function with regards to off time and/or dyskinesia. * able to utilize a digital product, either alone or assisted by a caregiver. exclusion criteria: * consistent use of a wheelchair or walker which may interfere significantly with the remote monitoring of pd motor symptoms. * lack of understanding and proficiency in the danish language. * inability to use wearable devices due to non-compliance, physical and/or skin sensitivity. * suffering from severe psychiatric disorders. * otherwise not qualified to receive advanced treatment (e.g., advanced cancer, severe heart failure). * already undergoing advanced treatment. * diagnosed with atypical or secondary parkinsonism. * other patient groups otherwise deemed ineligible by the project manager.

Keywords: wearable devices objective measurements advanced treatment digital health
fetal hemoglobin induction treatment metformin

Conditions: Sickle Cell Anemia; Sickle Cell Disease; Hemoglobin Disorder

Summary: the purpose of this study is to determine whether metformin is effective in the treatment for sickle cell anemia (sca).

this is a dose escalation, pilot study for subjects with sickle cell anemia (sca) disease to determine if metformin has a beneficial effect on the treatment and quality of life of sca patients.

Eligibility criteria:
inclusion criteria: 1. confirmed diagnosis of sickle cell anemia 2. age greater than or equal to 10 and less than or equal to 60 years of age. 3. if on hydroxyurea, fetal hemoglobin less than 20% at a stable dose (mg/kg) determined by the primary hematology provider over at least four months. 4. creatinine less than or equal to 1.4 mg/dl and estimated glomerular filtration rate greater than 45 ml/min/1.73 m2 5. liver function tests (specifically alt and conjugated bilirubin) less than or equal to 4 times upper limits of normal. exclusion criteria: 1. failure to meet inclusion criteria 2. simple or chronic red blood cell transfusion therapy in the last 3 months or a hba level greater than 5% in sca patients 3. refusal to use medically effective birth control if female and sexually active. 4. if on hydroxyurea, not at stable dose of hydroxyurea for a minimum of 4 months (temporary exclusion). 5. creatinine greater than 1.4mg/dl 6. liver function tests (alt and conjugated bilirubin) greater than 4 times upper limits of normal.

Keywords: metformin sickle cell anemia sickle cell disease hemoglobinopathies hemoglobin disorder blood disease hemoglobin disease
antibiotic prophylaxis - amoxicillin

Conditions: Healthy

Summary: the hypothesis of the present study is that quantitative and qualitative oral microflora alterations and changes in antibiotic susceptibility among oral commensal microflora will occur following a single dose administration of amoxicillin.

a total of 33 healthy volunteers, 16 males and 17 females, will be included. written informed consent will be obtained from all participants. subjects will be excluded if they have taken antibiotics within the previous three months, are pregnant, breast-feeding or allergic against penicillin. the participants will be given a single dose of 2 g amoxicillin. saliva samples will be collected before administration of antibiotics (day 1) and on day 2, 5, 10, 17 and 24. un-stimulated saliva will be accumulated in a plastic container. concentration of amoxicillin in saliva will be measured on day 1, 2 and 5. samples will be used for the determination of antibiotic concentration. analyses of the sensitivities to amoxicillin and some other clinically relevant antibiotic compounds will also be performed.

Eligibility criteria:
inclusion criteria: * written informed consent * healthy * age 18-45 * understands the study procedure and speaks swedish and/or english exclusion criteria: * treatment with antibiotics within the previous three months * pregnant * breast-feeding * allergic against penicillin * concomitantly participate in another medical product study * treatment with any kind of medication, health food preparations or probiotics

Keywords: antibiotic prophylaxis
a study to test the safety and effectiveness of an investigational vaccine in infants (v419-002)

Conditions: Bacterial Infections; Virus Diseases

Summary: the purpose of this study is to evaluate the safety, tolerability and immunogenicity of 4 different formulations of the hr5i vaccine (haemophilus influenzae type b conjugate, recombinant hepatitis b surface antigen, diphtheria, tetanus, 5-component acellular pertussis, and inactivated poliovirus types 1, 2, and 3). the primary hypothesis is that at least 1 of the 4 formulations of hr5i administered as a primary series at 2, 3, and 4 months of age will be acceptable (similar to targeted rates) with respect to postdose 3 antibody responses to all antigens.

participants will be randomized into 4 arms: ar51 (12, 10): arm receiving vaccine formulation containing 12 mcg of polyribosylribitol phosphate (prp) conjugates to tetanus toxoid (prp-t) and 10 mcg of hepatitis b surface antigen (hbsag) pr51 (3, 10): arm receiving vaccine formulation containing 3 mcg of prp conjugated to the outer membrane protein complex of neisseria meningitides (prp-ompc) and 10 mcg of hbsag pr51 (6, 10): arm receiving vaccine formulation containing 6 mcg of prp-ompc and 10 mcg of hbsag pr51 (6, 15): arm receiving vaccine formulation containing 6 mcg of prp-ompc and 15 mcg of hbsag

Eligibility criteria:
inclusion criteria: * healthy infants 2 months of age who have not received prior vaccinations for haemophilus influenzae type b (hib), hepatitis b, diptheria/pertussis/tetanus (dpt), or polio exclusion criteria : * documented hiv infection (child or mother) * documented hbsag-seropositivity (child or mother) * history of invasive hib disease, hepatitis b, diphtheria, tetanus, pertussis, or poliovirus infection * history of seizure disorder, developmental delay, or any other neurologic disorder * underlying medical conditions such as inborn errors of metabolism, failure to thrive, or any major congenital abnormalities requiring surgery * prior or anticipated receipt of immune globulin, blood, or blood products * known hypersensitivity to any component of the investigational vaccines being administered in this protocol * any history or condition that would exclude the child from receiving any vaccine administered under this protocol * any condition that, in the opinion of the investigator, may interfere with the evaluation of the study objectives
intraarticular analgesia after total knee arthroplasty, a randomised study

Conditions: Arthroplasty, Replacement, Knee

Summary: the study aims to compare two different kinds of pain treatment after total knee replacement (operation with artificial knee joint): 1) a large local injection in and around the knee, supplemented with injection the day after, or 2) the department's conventional pain treatment consisting of continuous nerve block in the groin.

postoperative pain after total knee arthroplasty is moderate to severe and can be difficult to treat. the current use of femoral nerve block by ropivacain pump for 48 hours provides considerable analgesia, but patients often experience slight motor block, inhibiting rehabilitation, and pain in the posterior part of the knee, innervated by the sciatic nerve. this study compares femoral nerve block to a new technique, where ropivacaine, ketorolac and adrenalin is used to infiltrate the tissue in and around the knee joint during surgery, and is injected by an intraarticular catheter at 10 pm on the day of surgery and again at 10 am the day after. data of pain scores, analgesia consumption, adverse effects and mobilisation is collected for the first four postoperative days.

Eligibility criteria:
inclusion criteria: * patients planned for primary total knee arthroplasty due to primary arthrosis exclusion criteria: * patients unable to provide informed consent * patients with contraindications for spinal anesthesia * patients with known hypersensitivity towards the used drugs * patients with severe chronic neurogenic pain or sensitivity disorders in the leg to be operated * patients who have undergone major bone surgery in the knee to be operated

Keywords: postoperative pain knee arthroplasty analgesia infiltration femoral nerve block
effect of dietary cholesterol on plasma lipids

Conditions: Dietary Modification; Nutritional and Metabolic Disease

Summary: the physicians committee is carrying out a research study to improve the investigator's understanding and expand the literature to quantify the effect of foods on blood cholesterol. this study will measure changes in low density lipoprotein (ldl) concentration, sometimes called "bad cholesterol," over 2 study periods of 4 weeks each, with 1 rest week in between. approximately 50 subjects will participate in this study.

in a 9-week double-blind, crossover trial, participants will consume baked goods with either 2 egg yolks or an isocaloric egg-free product daily for 4 weeks. after a one-week washout period, participants will cross to the other dietary intervention. participants will be asked not to make changes to their exercise patterns or diet, apart from consuming the provided products, for the study period. changes in ldl cholesterol concentrations will be the primary dependent variable. study evaluations, known as health assessments, will be held at the physicians committee's office. group assignment: after the study entry, will be assigned by chance, like the flip of a coin, to one of two groups. the participant will have an equal chance of being assigned to either group. each group will be asked to consume baked goods daily. the two groups will consume the same baked goods, but in a different order. the baked goods will be made from wheat flour with a small amount of sugar, salt, yeast, and other ingredients that are common to baked goods. there will be no animal-derived ingredients, except that some products will contain egg. each week, the participant will be given a week's worth of baked goods.

Eligibility criteria:
inclusion criteria: • following vegan diet for 6 or more months exclusion criteria: * following vegan for less than 6 months * smoking during the past six months * alcohol consumption of more than 2 drinks per day or the equivalent, episodic increased drinking (e.g., more than 2 drinks per day on weekends), or a history of alcohol abuse or dependency followed by any current use * pregnancy or intention to become pregnant during the study period * unstable medical or psychiatric illness * lack of english fluency * inability or unwillingness to participate in all components of the study * egg allergy * use of cholesterol-lowering medications

Keywords: dietary cholesterol cholesterol nutrition egg yolks eggs
bevacizumab versus ranibizumab for the treatment of diabetic macular edema

Conditions: Diabetic Retinopathy; Macular Edema

Summary: the purpose of this study is to compare the morphological and visual acuity outcomes associated with 1.5 mg bevacizumab versus 0.5 ranibizumab intravitreal injections for treatment of diabetic macular edema.


Eligibility criteria:
inclusion criteria: * center-involving diabetic macular edema unresponsive to laser therapy performed at least 3 moths prior to inclusion; * best corrected visual acuity equal or worse than 20/40 and better than 20/800; * central subfield macular thickness greater than 300 µm exclusion criteria: * aphakia * high-risk proliferative diabetic retinopathy * previous treatment for dme in the past three months

Keywords: diabetic retinopathy macular edema bevacizumab ranibizumab
an rct for the effect of biofeedback therapy the prevention of ar syndrome in rectal cancer patients

Conditions: Rectal Cancer

Summary: in patients who underwent sphincter preserving surgery with toal mesorectal excision and diverting stoma after neoadjuvant chemoradiation therapy for rectal cancer, the inestigators would evaluate the effect of a biofeedback therpy before stoma closure on their anorectal function after stoma closure.


Eligibility criteria:
inclusion criteria: * rectal cancer patients * neoadjuvant chemoradiation therapy (+) * sphincter saving surgery with total mesorectal excision (+) * temporary loop stoma (+) * adult who is 17 years or older * patinet who aggree with our study * if woman is childbearing age, her pregnancy test shoud be indentified 'negative' exclusion criteria: * patients who have been enrolled to other clinical studies related to this study * patients who underwent diverting stoma before neoadjuvant chemoradiation * temporary end -ostomy (+) * uncontrolled metabolic or systemic disease * patients who do not understand the purpose of this study because of dementia or pshycologic problem * mrsa or clostridium difficille (+) * pregnant or during breast feeding * serious complication after sphincter saving surgery