Kornimate/medical-research-clean huggingface dataset:
combined photo-biomodulation at acupuncture points, autologous prp, and umbilical cord-derived exosome therapy in autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: this randomized controlled trial aims to evaluate the efficacy of a combination of photo-biomodulation at acupuncture points, autologous platelet-rich plasma (prp), and umbilical cord-derived exosome therapy in children with autism spectrum disorder (asd). the study will compare these interventions against standard care to determine their impact on the severity of autism symptoms, as measured by the childhood autism rating scale (cars) and other related markers.

the study involves three main interventions: 1. photo-biomodulation (pbm): pbm will be performed once a week using an 810nm, 210mw laser probe for 20 seconds at each selected acupuncture point. 2. autologous platelet-rich plasma (prp): prp will be administered at 0 day, 15 day, 30 day, and at 45th day adp-derived autologous prp. 3. exosome therapy: exosomes derived from umbilical cord tissue will be injected intravenously at laser acupuncture points. the prp-exosome sessions will be repeated at 15 days, 6 weeks, 12 weeks, and 24 weeks. the study will run over a period of 6 months, with follow-ups and assessments at each phase. the primary outcome measure will be the change in cars score, with secondary outcomes including additional asd markers.

Eligibility criteria:
inclusion criteria: * • diagnosis of autism spectrum disorder based on dsm-5 criteria * age 3-12 years * stable on current medications for at least 4 weeks prior to study entry * parents or legal guardians willing to provide informed consent exclusion criteria: * • severe comorbid medical conditions * prior stem cell or exosome therapy * history of hypersensitivity to any component of the interventions * inability to comply with study procedures
6 minute propulsion test sensitivity to increased aerobic capacity

Conditions: Spinal Cord Injury

Summary: the goals of this project are to 1)determine the responsiveness of the 6 minute push test (6mpt) and 2) explore the relationship between 6mpt distance and measures of handicap, wheelchair satisfaction, depression, and self-reported avoidance of environmental features.

the 6 minute walk test is a widely used assessment of aerobic capacity, function, and functional change in the ambulatory population. a similar clinical and research outcome instrument that is responsive to changes in aerobic capacity and function are lacking for persons with spinal cord injury (sci). a 6 minute push test, adapted from the 6 minute walk test may fill the void. the primary aim of this project is to assess if distance traveled in 6 minutes of wheelchair propulsion changes after an increase in aerobic capacity. we hypothesize that participants will push farther in 6 minutes after their aerobic capacity increases. the secondary aim is to explore the correlation between 6mpt distance and handicap, depression, wheelchair satisfaction, and self-reported avoidance of environmental features. we hypothesize increasing 6mptdistance will be correlated with decreasing depression, decreasing handicap, decreasing self-reported avoidance of environmental features, and increasing wheelchair satisfaction. this is a low risk, high benefit study.

Eligibility criteria:
inclusion criteria: * t1 or lower injury * at least 1 year post-injury * able to self-propel a manual wheelchair * enrolled in tmp-mn-006 exclusion criteria: * not enrolled in the irb approval parent study, "exercise treatment of obesity-related secondary conditions in adults with paraplegia", tmp-mn-006 * unstable angina or myocardial infarction within the past month * resting heart rate \>120 * systolic blood pressure \> 180 mm hg * diastolic blood pressure \> 100 mm hg

Keywords: aerobic capacity
the effectiveness of megadose shinbaro pharmacopuncture for patients with chronic shoulder pain

Conditions: Shoulder Joint Disorder

Summary: this study is a prospective, case-control observational trial. the investigators will compare the megadose shinbaro pharmacopuncture group to the control group to analyze the effectiveness of shoulder megadose shinbaro pharmacopuncture.

pharmacopuncture is a treatment that combines 2 of the most frequented korean medicine treatment methods - traditional acupuncture and herbal medicine - by injecting herbal medicine extract at acupoints. shinbaro is a refined herbal formulation used to treat inflamed lesions and bone diseases. this treatment is known to be an important part of korean medicine treatment. however, there has been no specific value for the effect of this treatment. therefore, the investigators conducted observational trial to analyze the effectiveness of megadose shinbaro pharmacopuncture on shoulder. from dec 2019, the investigators will collect 80 patients with chronic shoulder pain on both or each shoulder with the numeric rating scale(nrs) over 4. the investigators will compare pain, dysfunction, quality of life and satisfaction of patients who are treated with korean medical treatment including megadose shinbaro pharmacopuncture and patients who are treated with korean medical treatment not including megadose shinbaro pharmacopuncture. for these two groups, the investigators will compare nrs(numeric rating scale), visual analogue scale(vas), range of motion(rom), shoulder pain and disability index(spadi), patient global impression of change (pgic) and euroqol 5-dimension (eq-5d-5l).

Eligibility criteria:
inclusion criteria: * patients with nrs ≥ 4 for shoulder pain over 3weeks * patients aged 19-70 years on the date they sign the consent form. * patients who provide consent to participate in the trial and return the informed consent form exclusion criteria: * patients who have been diagnosed with a severe disease that may cause shoulder pain, * patients with progressive neurological deficit or with serious neurological symptoms caused by spinal cord compression. * patients who visited a hospital in pain caused by a traffic accident. * patients with a severe mental illness. * patients who are difficult to complete the research participation agreement

Keywords: shoulder joints shinbaro pharmacopuncture megadose shinbaro pharmacopuncture chronic shoulder pain shoulder pain
immobilization without reduction vs. reduction under general anesthesia in metaphyseal fractures of the distal radius

Conditions: Radius Fracture Distal

Summary: distal radius metaphyseal fractures are the most frequent in the pediatric population. the current treatment for angulated or shortened fractures is effective. still, it exposes children to anesthetic risks supported by the pain generated by the reduction. due to the excellent remodeling capacity of bone at an early age, it is questionable whether an anatomical reduction is necessary. the clinical experiment's objective is to compare the functional result of immobilization without reducing angulated or displaced metaphyseal fractures of the distal radius against fractures brought to reduction under general anesthesia. means difference in function subdomain of the upper limb of the promis® scale is the primary outcome. the secondary results are wrist mobility, radius alignment, wrist articular relationships, and surgical complications.

the participant will be recruited in one center. if participants and their parents accept to participate in this study, treatments will be randomly allocated using the big stick design technique with a maximum tolerated imbalance of 2. the sequence will be generated by a research assistant who is completely independent of the study, does not know the purpose of the study and the interventions. each of the random numbers will be stored in an opaque envelope sealed externally with the order in which they should be opened. patient registration and follow-up information will be stored in redcap®. clinical and radiographic outcomes will be evaluated.

Eligibility criteria:
inclusion criteria: * children from 5 years to 10 years * unilateral metaphyseal distal radius fracture * fracture shortening of 0 to 10mm or angulation of 10 ° to 20 ° in the oblique plane. (ao 23-m 2-3 or 23r-m 2-3) * admission in the first 14 days after the fracture exclusion criteria: * polytrauma: injury severity score (iss)\> 16 * associated fracture in the same limb. * neuromuscular pathology (e.g., cerebral palsy, spinal muscular atrophy, duchenne disease) * open fractures. * history of fractures, septic arthritis, or osteomyelitis in the same limb. * neurological or vascular injury in the fractured upper limb. * known alteration of bone metabolism (e.g., osteogenesis imperfecta, rickets, osteopetrosis, skeletal dysplasias, lysosomal storage diseases). * congenital longitudinal deficiency.

Keywords: radius fracture children conservative treatment distal radius
treatment of parkinson's disease with eliprodil

Conditions: Movement Disorders; Parkinson Disease

Summary: patients with parkinson's disease are missing the chemical neurotransmitter dopamine. this occurs as a result of destructive changes in an area of the brain responsible for making dopamine, the basal ganglia. patients with the disease experience, rigid muscles, stooped posture, and a shuffling-type walk (gait). in this study researchers plan to evaluate the effectiveness of the drug eliprodil for the treatment of parkinson's disease. eliprodil works by blocking special receptors (nmda) that are associated with the symptoms of parkinson's disease.

the objectives of this study are to evaluate the acute effects of the nr2b subtype-selective nmda antagonist eliprodil on levodopa-associated motor response complications in patients with advanced parkinson's disease (pd).

Eligibility criteria:
all patients will carry a diagnosis of idiopathic parkinson's disease based on the presence of a characteristic clinical history and neurologic findings. most will have relatively advanced disease with associated motor response complications. males and females between the ages of 18-75. no presence or history of any medical condition that can reasonably be expected to subject the patient to unwarranted risk. no patients with baseline qtc prolongation (greater than 440 msec). no pregnant women nor those not practicing effective means of birth control.

Keywords: dyskinesias glutamate antagonist levodopa
do rocker bottom shoes and ankle-foot orthoses reduce pain and improve mobility for ankle osteoarthritis patients

Conditions: Ankle Osteoarthritis; Healthy Ankles

Summary: ankle osteoarthritis (oa) is a painful, progressive condition that can severely limit physical activity and reduce quality of life. rocker bottom (rb) shoes and ankle-foot orthoses (afos) are commonly used as non-surgical treatments for ankle oa. rb shoes have a curved sole in the toe to heel direction that may alleviate joint pain by reducing ankle range of motion (rom). similarly, afos may reduce joint motion by securing the foot and ankle within the ankle-foot orthosis (afo) frame. this study aims to determine the ability of rb shoes and afos to improve mobility, by relieving pain and reducing joint rom.

the investigators' objective is to compare two non-surgical treatments (rb shoes and toeoff brand afos) in oa subjects by measuring their mobility and pain during and after a multi-week trial period. the investigators will use a biplane fluoroscopy system to measure foot joint motion for each condition (rb shoe, afo, control shoe). this will yield clinical and biomechanical measures of the effect of each orthotic on mobility, pain, and joint rom in an ankle oa population. the investigators will also compare the clinical and biomechanics outcomes of oa subjects to those of control subjects. this information will provide evidence to support clinical decision making. aim 1: compare the daily sep count, self-selected walking speed, clinical outcome measures (promis surveys) of a control shoe, rb shoe, and afo worn over a multi-week trial period. aim 2: evaluate the effect of a control shoe, rb shoe, and afo on the foot and ankle joints range of motion. aim 3: compare the ankle oa clinical and biomechanical outcome measures for the control shoe, rb shoe, and afo to a healthy control group wearing control shoes. the efficacy of conservative treatments such as rb shoes and afos for managing oa pain and discomfort is not well supported by clinical evidence. by using biplane fluoroscopy along with validated clinical measures of pain and mobility, this study will elucidate the mechanism by which rb shoes and afos biomechanically alter foot and ankle function. identifying beneficial treatment strategies for people with ankle oa will help them regain their mobility and improve their quality of life.

Eligibility criteria:
inclusion criteria: for osteoarthritis patients: * radiographic evidence of tibiotalar osteoarthritis * ambulatory for healthy controls: * ambulatory * aged 18 or older exclusion criteria: for osteoarthritis patients and healthy controls: * subtalar joint arthritis * plans for surgical treatment of ankle osteoarthritis within the next 4 months * surgical, neurological, metabolic, or lower limb musculoskeletal problem that would impair study measures * inability to walk unassisted during short, repeated walking trials * rheumatoid arthritis * inadequate cognitive or language function to consent or to participate * no phone number or stable mailing address

Keywords: rocker bottom shoe ankle-foot orthosis ankle osteoarthritis
assessment of treatment response using pet/ct scanner - non hodgkin's lymphoma

Conditions: Lymphoma, Non-Hodgkin

Summary: in this study the treatment process will be closely monitored using a novel imaging technology, a pet/ct scanner. pet stands for positron emission tomography and in this case it will be combined with a conventional x-ray computerized tomography (ct) scan. this is not a study of any particular form of treatment. the treatment you receive will be the most appropriate standard treatment whether you are in the study or not. the goal of radiation therapy is to deliver a given amount of radiation dose to the area where there is a lymphoma tumour. we are doing this study to see which part of the tumour reacts to the radiation treatment, and which part does not react, by monitoring the progress of your treatment with a combined pet/ct scan. in particular, changes of the size and shape of the tumour that occur during the treatment can be detected and will be visible on the images. these images will be thoroughly analysed. the ability of the pet/ct scanner to detect these changes during a course of radiation treatment will be the subject of this study. we will also be able to see if this information will eventually relate to or predict whether lymphoma tumours will be completely eradicated by the treatment.


Eligibility criteria:
inclusion criteria: * histologic diagnosis of nhl:any histology * stage i-iv * measurable disease by ct scan (gross disease measuring at least 2 cm in any one dimension) * planned radiation dose prescription \>=30 gy, \>=20 fractions, \>=3weeks duration * informed consent * previous chemotherapy is allowed, provided the above eligibility criteria are me exclusion criteria: * to minimize effect from breathing motion, patients presenting with parenchymal lung tumours and tumours involving liver and stomach will be excluded * concurrent systemic chemotherapy (glucocorticoids when used alone is allowed)
effectiveness of online mindfulness platform in improving anxiety, depression, and stress in adult

Conditions: COVID-19 Pandemic; Emotions; Online Mental Health Program

Summary: during the covid-19 pandemic, adults may experience emotional stress and impact. to reduce the risk of cross-infection, this study aims to use online mindfulness training to improve emotional well-being during the pandemic and assess their effectiveness.

he covid-19 pandemic had a detrimental global impact on the health of most populations. it causes and also generates further damage to physiology and psychology. mindfulness is recognized as an effective method for improving the symptoms of physical and mental problems. the purpose of this review will explore the efficacy of an online mindfulness intervention for individuals or groups that impacted symptoms of physiology and psychology in adults during the pandemic base on the principle of evidence-based medicine. at the same time, a set of mindfulness intervention plans will be developed based on the best evidence searched, and a pilot study will be conducted. therefore, this research design will be divided into two stages. in the first stage, six electronic bibliographic databases will be comprehensively searched for randomized controlled trials that have been published from february 2020 to currently published articles. the research subjects are adults who live in the community and accept online mindfulness intervention. quality assessment will be performed according to the cochrane collaboration's risk of bias tool will be used for randomized controlled clinical trials (rcts). a meta-analysis of the intervention timing and measurements will be performed using review manager 5.1 software. the second phase will be a randomized controlled trial pilot study of mindfulness interventions, the research subjects will be divided into two groups, namely the mindfulness intervention experimental group (e) and the control group (c). the researcher uses structured questionnaires to collect data before intervention (to) and at 4 weeks (t1), 8 weeks (t2) after the intervention. data will be analyzed using the generalized estimating equation to analyze the repeated measurements and intention-to-treat analysis for reducing attrition bias.

Eligibility criteria:
inclusion criteria: * patients over 20 years of age * conscious * able to communicate in taiwanese exclusion criteria: * patients currently receiving antidepressant or anti-anxiety medications * patients unable to communicate verbally * patients who refuse to provide informed consent

Keywords: covid-19, physiology, psychology mindfulness online mindfulness
effect of mizagliflozin repeat dosing on adverse events and postprandial glucose excursions

Conditions: Postbariatric Hypoglycemia

Summary: this is a phase 2 crossover, randomized, placebo-controlled, single-blind, repeat dose study in pbh subjects to determine the effect of mizagliflozin on adverse events and postprandial glucose excursions.

this is a phase 2 crossover, randomized, placebo-controlled, single-blind, repeat dose study in pbh subjects to determine the effect of mizagliflozin on adverse events and postprandial glucose excursions. this study will examine repeat doses of mizagliflozin and placebo while also evaluating dosing regimen. up to 15 subjects are expected to complete the study. subjects will be randomly assigned to a treatment arm within a cohort. each subject should receive placebo and 2 active dose regimens in a crossover fashion.

Eligibility criteria:
inclusion criteria: * roux-en-y gastric bypass surgery performed \> 6 months prior to enrollment * diagnosis of pbh exclusion criteria: * history of current medical conditions (other than pbh) which may result in hypoglycemia such as insulinoma, adrenal insufficiency, insulin autoimmune hypoglycemia, congenital hyperinsulinemia. * current use of insulin or insulin secretagogues * history of current fasting hypoglycemia * pregnancy and/or lactation: for women of childbearing potential: there is a requirement for a negative urine pregnancy test and for agreement to use contraception during the study and for at least 2 weeks after participating in the study
peer-mentor support for older vulnerable myocardial infarction patients

Conditions: Myocardial Infarction

Summary: background: advanced treatment regimens have reduced cardiovascular mortality resulting in an increasingly older myocardial infarction (mi) population in need of cardiac rehabilitation (cr) , the majority (74%) is above 60 years. the positive effect of cr is well established; cr reduces cardiovascular mortality, lowers hospital admissions, and improves quality of life among patients with ischemic heart disease. these positive effects of cr has also been established among older patients. the inherent problem lies in the low attendance rate, often below 50%. several studies, including studies from denmark, have shown that low participation in cr is most prevalent among older, vulnerable female patients. the notion vulnerable covers patients with low socioeconomic position (sep), patients with non-western background and patients living alone, as these groups have particularly low cr attendance. effective interventions aiming at increasing cr attendance among these low attending groups are thus warranted and the current study will seek to address this. aim: to test feasibility and acceptability of methods used in a peer-mentor intervention among older female and vulnerable post mi patients. design and methods: the study is designed as a one arm feasibility study. patients (n=20) are recruited by a dedicated research nurse before discharge from the cardiology department at nordsjællands hospital. data is collected at three timepoints, baseline, 12 weeks and 24 weeks. the patients (mentees) are matched with peer-mentors. peer-mentoring (i.e. mentoring by a person with a similar life situation or health problem as one self) is a low-cost intervention that holds the potential to improve cr attendance and improve physical and psychological outcomes among older patients. peer-mentors are role models who can guide and support patients overcoming barriers of cr attendance. peer-mentoring is unexplored in a cr setting among older, female and vulnerable mi patients; establishing the novelty of the current study.


Eligibility criteria:
inclusion criteria: * ≥65 years and diagnosed with mi and referred to cr and female or low sep or single living or non-western background. exclusion criteria: * patients unable to provide written consent.
clinical study to evaluate efficacy and safety of ant-301 in patients with knee osteoarthritis in grade iii/iv by k/l

Conditions: Osteoarthritis, Knee

Summary: this is a phase i open study to evaluate the efficacy and safety of ant-301 in patients with knee osteoarthritis k\&l grade iii/iv.

study design: open-label, single-center, dose-escalation study

Eligibility criteria:
inclusion criteria: 1. patients who have been provided with information about the clinical trial and have provided written consent on the informed consent form 2. patients aged 19 to 70 years old. 3. patients diagnosed with k\&l grade iii/iv knee osteoarthritis 4. patients with a vas pain score of 40mm or higher when measured on a 100-point scale exclusion criteria: 1. patients with joint diseases other than osteoarthritis 2. patients who have undergone knee joint surgery or radiation therapy to the knee joint within 6 months prior to the screening 3. patients who received intra-articular injections within 6 months prior to the screening 4. patients who have received systemic steroid therapy within 3 months prior to the screening 5. patients who have received immunosuppressive agents within 3 months prior to the screening 6. patients who have received cell therapy or gene therapy to the target knee within 5 years prior to the screening 7. patients who are unwilling to use contraception during the clinical trial period