Kornimate/medical-research-clean huggingface dataset:
a study of family caregivers' needs, burden of care and quality of life over the course of a cancer illness

Conditions: Family Caregivers; Cancer; Health Related Quality of Life

Summary: this research will determine (a) the unmet needs of family caregivers of adult cancer patients and (b) determine the impact on stress, care burden and quality of life. a cross-sectional questionnaire methodology will be used to answer the research questions. 510 family caregivers at different stages of patients' cancer journey will be recruited. the study duration is expected to take two years. research findings will address the knowledge gap of caregivers' needs and stress, burden and quality of life and support plans to help caregivers.

the literature suggests that caregivers have unique psychological, emotional and lifestyle needs but there is a paucity of such information of caregivers in singapore. as this study is exploratory, no a priori hylothesis has been made. the theoretical framework guiding this research is fulfillment theory in which the existence and perception of needs and need fulfillment are hypothesized to be antecedents to the experience of satisfaction about care. a cross-sectional questionnaire methodology will be used to answer the research questions. caregivers in this study are defined as: a family member who lends physical, emotional or other support to someone at any time during the cancer journey. a power calculation was not done, instead the sample size of 510 was based on what may be practically achievable and feasible for the duration of the short-term quantitative study. descriptive statistics will be used to characterize the distribution of socio-demographic characteristics and caregiver-related information. regression analysis will be used to evaluate difference in overall and domain specific needs across selected characteristics. problems identified by caregivers will be dichotomized as present or absent and chi-square tests will be used to evaluate associations with selected characteristics.

Eligibility criteria:
inclusion criteria: an adult providing care for a familyt member with cancer aged between 21 and 90 years and willing to participate in the study exclusion criteria: caregiving adults who are not family members and not willing to particfipate in the study

Keywords: family cancer caregivers, needs burden of care quality of life
pharmacokinetic study of 48-hour sevoflurane inhalation using a disposable delivery system (anaconda©) in obese icu patients

Conditions: Obesity

Summary: describing a pharmacokinetic model of 48-h sevoflurane sedation in obese icu patients

prospective clinical monocentric study in icu with sedated ventilated obese patients with sevoflurane during 48 h with the anaconda® system, establishing pharmacokinetic model of sévoflurane and its metabolites (hydroxyfluroisopropanol, fluoride)

Eligibility criteria:
inclusion criteria: * adult patients ventilated more than 48 h stable respiratory and hemodynamic conditions consent of patients or family arterial line bmi \>30 exclusion criteria: * acute kidney injury bmi \<30 sevoflurane anaphylaxia

Keywords: pharmacokinetics sevoflurane obesity sedation icu patients
rehabilitation robotics after a stroke

Conditions: Subacute Stroke

Summary: upper limb motor control after a stroke may be improved with rehabilitation robotics at a subacute stage. the aim of this multicenter controled randomized single blind study is to define the place of rehabilitation robotics at this phase of the rehabilitation process. both groups will realize the same time of rehabilitation. the cost benefit ratio will be compared in each group through medical assessment of improvement and definition of the costs due to the rehabilitation process.


Eligibility criteria:
inclusion criteria: * ischemic or hemorrhagic stroke of the middle cerebral arteria territory * 18 to 80 years old * stroke onset between 3 weeks to 3 months,with or without aphasia, with or without lateral neglect and homonymous hemianopia, with or without visual neglect * 10\<or= fugl meyer upper limb score \<or= 40 * upper limbs pain less or equal than 3/10 (vas) * inpatient or outpatient rehabilitation * signed inform consent exclusion criteria: * ischemic or hemorrhagic stroke of anterior or posterior cerebral artery * ischemic or hemorrhagic stroke of the brainstem * major aphasia evaluated by a boston diagnostic aphasia examination (bdae) score less or equal to 3 * asthenia not allowing to work 60 minutes with the robot. * serious visual deficiency not allowing to use the robot * impossibility to install the arm on the robot because of a serious and uncontrolled spasticity or for any other reason * pronounced and constant muscular contractures, or deformation affecting the use of the extremity * upper limb's pain superior to 3/10 and/or being worse at the active and passive mobilization * serious infection and/or instability of vital functions * perfusion of the affected upper limb not removable * incapacity to stay on a chair * contraindicated sitting position * permanent deviation of the head and\\or of the eyes * perturbed or non-cooperative patient * patients that must have to be isolated due to an infection process * bone fracture of the paretic limb with an onset less than 3 months stabilized or not

Keywords: stroke rehabilitation robotics motor control upper limb
effect of long-term oxygen therapy on exercise capacity and quality of life in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension

Conditions: Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension

Summary: in this randomized-controlled, cross-over trial the investigators test the effect of long-term oxygen therapy (\> 16h/day) given for 5 weeks with a wash-out period between phases of 2 weeks on exercise performance and quality of life and many physiological parameters in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension.


Eligibility criteria:
inclusion criteria: - adult patients with established diagnosis of pulmonary arterial or chronic thromboembolic pulmonary hypertension (class i and iv according to the latest who classification scheme of dana point 2008) on optimized medical therapy and in stable condition for at least 4 weeks, who desaturate in the 6 minute walking test by =4% to values \<92%. exclusion criteria: * patients in unstable conditions requiring frequent therapeutic adaption * pregnant women * patients with pulmonary venous hypertension due to left heart diseases * patients with relevant concomitant lung disease and severe daytime hypoxemia
the effect of vibration on pain during subcutaneous heparin injection

Conditions: Pain; Asthma; Pulmonary Disease; Chest Disorder

Summary: aim: the aim of this research will to examine the effect of the local vibration technique applied to the injection site during subcutaneous low molecular weight heparin (lmwh) injection. methods: the patients will randomly assigned to an experimental (vibration) group , a placebo control group, and a nonintervention control group. participants in the experimental group will give slight vibration to the injection site before the injection will administered; for participants in the placebo group, the device will placed on the injection site but with the vibration button kept switched off, while for the nonintervention control group, routine subcutaneous low molecular weight heparin injection will administered. the level of pain felt by the participants during the administration of the injection will assess with a visual analog scale.


Eligibility criteria:
inclusion criteria: * being over the age of 18 * having a doctor's prescription for subcutaneousheparin 0.6 ml treatment with a ready-to-use syringe and not yet having begun treatment * having no coagulation disorder * having no disorder which could affect pain perception, * having no incision, lipodystrophy or finding of infection at the injection site, * having no communication problem, and voluntarily agreeing to participate in the research exclusion criteria: * being under the age of 18 * having diabetes mellitus * peripheral vascular disease, etc. which could affect the perception of pain * not being conscious, refusing to participate in the research or opting to leave the study at any point.

Keywords: subcutaneous heparin injection pain non-pharmacological method vibration
microcirculatory mapping of the aging hand and foot

Conditions: Cutaneous Microcirculation in Vascular Diseases

Summary: currently, dorsal hand rejuvenation is an upcoming issue as patients seek plastic surgeons to address this highly visible area, although no specific statistics concerning the number of patients undergoing dorsal hand rejuvenation have been published yet. the solitary use of fillers, fat, sclerotherapy, skin excision, resurfacing and combinations of the above mentioned therapies have been reported in the literature, but still there is a lack of scientific literature about functional microcirculation of the dorsum of the hand. furthermore, there is a lack of scientific data about functional microcirculation of the plantar foot in healthy subjects compared to patients suffering from diabetes mellitus or peripheral arterial occlusive disease. consequently, the aim of this study is the evaluation of the functional microcirculation of hands and feet in healthy subjects as well as patients suffering from the above mentioned diseases.


Eligibility criteria:
inclusion criteria: * both healthy subjects and patients suffering from diabetes mellitus or manifested peripheral arterial occlusive disease aged between 18 and 75 years exclusion criteria: * soft tissue inflammation or osteomyelitis, liver disease, cardiac dysfunction, arterial hypotension
coagulation monitoring in patients on extracorporeal membrane oxygenation (observational study)

Conditions: Coagulation and Hemorrhagic Disorders; Extracorporeal Membrane Oxygenation Complication

Summary: coagulation disorders are on top of the list of extracorporeal-membrane oxygenation (ecmo) complications. they contribute significantly to morbidity and mortality of ecmo patients. this observational study aims to evaluate coagulation profiles of ecmo patients treated on the intensive care units of the department of anaesthesiology of lmu munich.

coagulation disorders are on top of the list of extracorporeal-membrane oxygenation (ecmo) complications. they contribute significantly to morbidity and mortality of ecmo patients. this observational study aims to evaluate coagulation profiles of ecmo patients treated on the intensive care units of the department of anaesthesiology of lmu munich. adult ecmo patients are included in the study after informed consent. bleeding and thromboembolic complications as well as treatment details are recorded. additional coagulation laboratory markers (such as von-willebrand-factor, adamts13-protease, platelet function tests and thromboelastometric tests) are correlated with clinical signs of bleeding. regular ultrasound examination of the large vessels are performed to screen for thrombosis.

Eligibility criteria:
inclusion criteria: * patient treated on icu of department of anesthesiology of lmu munich * treated with ecmo * age \>/= 18 years (adult patients only) * informed consent exclusion criteria: * underage patients * pregnant patients * hemoglobin level \< 8mg/dl

Keywords: ecmo haemostasis coagulation haemostatic alterations
left ventricular assist device combined with allogeneic mesenchymal stem cells implantation in patients with end-stage heart failure.

Conditions: Heart Failure; Ischemic Cardiomyopathy

Summary: the aim of the study is to investigate safety and efficacy of intramyocardial implantation of allogeneic mesenchymal stem cells in patients with end-stage ischemic cardiomyopathy undergoing left ventricular assist device implantation.

end-stage ischemic cardiomyopathy (icm) with non-graftable coronary arteries is a common and debilitating problem. the ultimate therapeutic goal in such cases is cardiac transplantation which is restricted by donor availability. alternatively, left ventricular assist devices (lvad) are increasingly used as bridge to transplantation or more recently as destination therapy in non-transplant candidates. widely used second- and third-generation continuous-flow lvad offer symptomatic relief and prolong life. however, lv unloading rarely improves native heart function in ischemic hearts. we aim to increase myocardial viability and improve native cardiac function in patients with end-stage icm by injecting allogeneic bone marrow stem cells at the time of lvad implantation.

Eligibility criteria:
inclusion criteria: * age 18 to 75 years * end-stage heart failure due to ischemic cardiomyopathy that requires mechanical support according to current indications * ability to provide informed consent exclusion criteria: * not willing to provide informed consent

Keywords: stem cell implantation coronary artery disease left ventricular assist device
protein kinase a in prostate cancer tissue.

Conditions: Prostate Neoplasm; Inflammation; Benign Hyperplasia of Prostate

Summary: prostate cancer is the most common malignancy in men. documented risk factors of prostate cancer are age, ethnicity, various genomic mutations and family history of prostate cancer. the cellular mechanisms of malignant transformation are numerous and not completely understood. a possible mechanism is induction of an inflammation resulting in cellular atypia and pre-malignant changes in the affected tissue by inducing a pro-inflammatory response or changes in extra cellular matrix. protein kinase a (pka) is a key stone enzyme in various intra-cellular processes. various infections' inflammations and malignancies were proved to impact pka activity. the research hypothesis is that prostate cancer tissue will show a unique profile of pka activity, regulation and intracellular distribution.

the study will be conducted among men referred to prostate biopsy due to clinical suspicion of malignancy. 100 consecutive patients will undergo prostate biopsies. biopsies will be taken from both lobes of the prostate (standard protocol) and additional biopsies will be taken according to mri findings (fusion biopsies) if relevant. one additional biopsy will be taken from each lobe of the prostate and immediately freezed in -80 celsius degrees. routine biopsies will be fixed in formaldehyde and embedded in paraffin and will undergo routine pathological analysis and staining. following pathological analysis, paraffin slides will be undergo immunohistochemically staining for pka, comparing cancerous tissue to normal surrounding tissue. the fresh frozen tissue will undergo western blot analysis for quantitative expression of pka and its sub units.

Eligibility criteria:
inclusion criteria: * men * clinical suspicion of prostate cancer * referred for biopsy * able to sign informed consent. exclusion criteria: * previous prostate irradiation * chronic prostatitis * previous prostate surgery * recent urinary tract infection (3 months prior to biopsy). * indwelling urinary catheter

Keywords: protein kinase a immunohistochemistry prostate cancer prostate biopsy
evaluation of transnasal endoscopy during covid-19 pandemic

Conditions: Endoscopy

Summary: patients who received the indication for endoscopic diagnostics using gastroscopy in transnasal technique will be included into the study. the examination is carried out in standard technique and is not influenced by the study. following the examination, patient data is collected pseudonymously and a questionnaire is submitted to the patient.

covid-19 is transmitted, among other things, by a droplet infection. conventional gastroscopy through the patient's mouth is therefore considered a high-risk examination for the medical and nursing staff. alternatively, gastroscopy can also be performed through the patient's nose. an advantage here is that the aerosol formation is naturally significantly reduced and the patient usually does not need sedation, since in transnasal endoscopy no stranglehold occurs. transnasal endoscopy therefore appears to us, especially during the covid-19 pandemic, as a safe alternative to conventional gastroscopy. patients who received the indication for endoscopic diagnostics using gastroscopy in transnasal technique will be included into the study. the examination is carried out in standard technique and is not influenced by the study. following the examination, patient data is collected pseudonymously and a questionnaire is sumbitted to the patient. only patients who have the indication for gastroscopy in transnasal technique are included. a specific risk to patients cannot be foreseen.this study does not interfere with diagnostics or therapy.

Eligibility criteria:
inclusion criteria: * indication for transnasal endoscopy exclusion criteria: * pregnancy * breast feeding * contraindication to transnasal endoscopy * pronounced blood clotting disorders

Keywords: gastroscopy transnasal nursing
motor coordination and grip strength of the dominant and non-dominant hand and wrist in post-stroke patients.

Conditions: Stroke

Summary: this study aimed to assess how stabilization of the trunk and the upper extremity can change the parameters of hand/wrist motor coordination and grip strength in dominant and non-dominant paretic upper limb, in post-stroke patients and neurologically healthy subjects.

the examination of the dominant and non-dominant paretic hand consisted of two motor tasks, carried out in two different starting positions: sitting and lying down (supine). during the first examination, the subject sat on the therapeutic table (without back support), feet resting on the floor. the upper limb was examined in adduction of the humeral joint, with the elbow bent in the intermediate position between pronation and supination of the forearm, with free wrist and the hand. in the supine position, the affected upper limb was stabilized at the subject's body (adduction in the humeral joint, elbow flexion in the intermediate position, wrist and hand free). the hand tutor device and an electronic hand dynamometer were used for the measurements. in each of the starting positions, after putting the glove on (using the hand tutor device), the subject was asked to make moves as quickly and in as full a range as possible. finally, the measurement of grip strength with a dynamometer was performed in both analyzed starting positions, after completing the range of motion and frequency tests.

Eligibility criteria:
stroke inclusion criteria:1) participants with ischemic stroke; 2) participants with hemiparesis after 5 to 7 week after stroke; 3) participants with stable trunk (the trunk control test 70-100 points); 4) participants who were in a functional state allowing movements of the upper extremity (fma-ue 40-66 motor function points); 5) muscle tension (mas 0 -1+); 6) no severe deficits in communication, memory, or understanding what can impede proper measurement performance; stroke exclusion criteria:1) stroke up to two weeks after the episode, 2) acute polyneuropathy and damage to peripheral nerves, 3) lack of trunk stability, 4) no wrist and hand movement, 5) muscle tension (˃2 mas), 6) high or very low blood pressure, 7) dizziness, a malaise of the respondents. healthy inclusion criteria - 1) the control group consisted of participants free from the upper extremity motor coordination disorders; healthy exclusion criteria: 1) participants with a history of neurologic or musculoskeletal disorders such as carpal tunnel syndrome, tendonitis, stroke, head injury, or other conditions that could affect their ability to active movement and grip hand; 2) with severe deficits in communication, memory, or understanding what can impede proper measurement performance;

Keywords: dominant hand non-dominant hand coordination grip strength stabilization stroke
evaluation of enamel demineralization during clear aligner orthodontic treatment

Conditions: White Spot Lesion

Summary: development of white spot lesions (enamel demineralization) will be evaluated quantitatively during clear aligner orthodontic treatment compared to conventional fixed appliances using quantitative light induced fluorescence (qlf)

white spot lesion (wsl) may develop around fixed orthodontic appliances. with clear aligners, however, the issue is not controversial. wsl will be monitored in 2 groups of patients; one group using clear aligners and one group wearing fixed orthodontic appliances for 3 months. qlf images will be taken before treatment (t0) and 3 months after commencement of the treatment (t1). the results will be compared between the two groups

Eligibility criteria:
inclusion criteria: * healthy patients from both genders aged (17 - 24 years). * class i malocclusion with mild to moderate crowding (≤ 5 mm). * non-extraction treatment plan. * optimum oral hygiene before treatment with no signs of gingivitis and/or periodontitis. * maximum of 3 restored teeth. * absence of defective enamel formation in the form of hypocalcification or hypoplasia. exclusion criteria: -patients with poor oral hygiene, defective enamel, extensive restorations and salivary glands diseases were excluded.

Keywords: white spot lesion qlf clear aligners
virtual occupational therapy application

Conditions: Stroke; Hemiparesis

Summary: virtual occupational therapy application (vota) combines low-cost human motion tracking, commercial game engine technology, and evidence-based occupational therapy (ot) practice in a computer-based virtual world in which stroke patients practice activities of daily living (adls). the protocol investigates the efficacy of vota therapy for upper extremity (ue) motor recovery and assesses system usability and user acceptance.


Eligibility criteria:
inclusion criteria: * participant is a hemiparetic stroke survivor; * time since last stroke at least 3 months; * participant has antigravity strength at the elbow to at least 45 degrees of active flexion in the stroke affected arm; * participant has antigravity shoulder strength to at least 30 degrees each in active flexion, abduction/adduction, and 15 degrees in active rotation from an upright seated position in the stroke affected arm; * participant has visual acuity with corrective lenses of 20/50 or better; exclusion criteria: * existing participation in an upper extremity stroke rehabilitation program or planned participation during the study period; * inability to understand and follow verbal directions; * determination that participation would result in over exertion or significant discomfort or pain; * determination that participation would result in significant agitation or elevated stress; * withholding or withdrawal of consent by the participant; * visual field deficit in either eye that impairs the ability to view the computer monitor; * hemispatial neglect that impairs the ability process and perceive visual stimuli provided through the computer monitor;

Keywords: stroke hemiparesis activities of daily living virtual world occupational therapy