Kornimate/medical-research-clean huggingface dataset:
intellicare in college students - implementation (iccs-i)

Conditions: Depression; Anxiety

Summary: this study is a hybrid effectiveness-implementation trial of the smartphone student stress-management app intellicare for college students. this intervention will be tested with university of illinois at chicago (uic) and northern illinois university (niu) students. during the study, participants will complete measures of depressive and anxious symptoms, as well as measures of mental health literacy, within the app.

in this study, students will be recruited to use the intellicare hub app and encouraged to use it daily.the overall aim of this study is to pilot the program, evaluation metrics, implementation strategies, data collection and assessment procedures for a larger implementation trial. during the trial, participants will be prompted to complete the phq-8 and gad-7 every week. at monthly intervals, participants will be prompted within the app to complete the depression literacy questionnaire and anxiety literacy questionnaire to measure mental health literacy, the knowledge and beliefs about services scale to measure knowledge of campus mental health services, the barriers to mental health help-seeking questionnaire to measure treatment barriers, and the cognitive and behavioral response to stress scale to measure cognitive and behavioral coping skills. counseling center utilization data will be extracted from the participating counseling centers' electronic medical records.

Eligibility criteria:
inclusion criteria: * participant is a student at the university of illinois in chicago or northern illinois university. \*participant owns a smartphone capable of running android 7 (or higher) or ios11 (or higher). * participant is 18 years of age or older exclusion criteria: \*none

Keywords: mental health app mobile phone stress management
evaluation of the safety and efficacy study of rgn-137 topical gel for junctional and dystrophic epidermolysis bullosa

Conditions: Junctional Epidermolysis Bullosa; Dystrophic Epidermolysis Bullosa

Summary: the objective of this study is to compare the efficacy and safety of rgn-137 topical gel with that of placebo gel for treatment of junctional epidermolysis bullosa (jeb) or dystrophic epidermolysis bullosa (deb).

rgn-137 will be evaluated for efficacy and safety compared to a placebo. a matched-pair design will be used to evaluate rgn-137 treatment versus placebo for treatment of 15 subjects with jeb or deb. eligible subject must have 1 set of matched-pair wound. the investigator will assign pair of index wounds, each wound with an area between 5cm2 and 50cm2, inclusive, for the eligible subject on day 1, and for each pair, one wound will be randomized to receive rgn-137 gel and the other to receive placebo gel. subjects and independent evaluator will be blinded to the treatment assignments for each wound.

Eligibility criteria:
inclusion criteria: * male or female and at least 4 years old with a diagnosis of deb or jeb * patients and their parents or guardians must be willing and able to provide written informed consent/assent * presence of 1 pair of stable index wounds within the specified size range at study 1. index wounds must have a surface area between 5 cm2 and 50 cm2, inclusive at the screening visit 2. the index wounds selected as pairing must be relatively matched in terms of size and location * women of childbearing potential must have a negative pregnancy test prior to randomization * sexually active subjects must agree to use medically accepted methods of contraception during the study exclusion criteria: * have any clinical evidence of local infection of the index lesion * use of prior or concomitant medication (any investigational drug within 30 days, immunotherapy or cytotoxic chemotherapy within 60 days, systemic steroidal therapy within 30 days, and topical steroidal therapy within 14 days) * history of sensitivity to any component of the treatment * neurological, cardiovascular, respiratory, hepatic, renal, or metabolic disease likely to interfere with the subject's participation in or completion of the study (at the discretion of investigator, participants with cardiomyopathy can participate) * current or former malignancy, including a history of squamous cell carcinomas * arterial or venous disorder resulting in ulcerated wounds * uncontrolled diabetes mellitus * pregnancy or breastfeeding during the study * girls or women who have had menarche but have not completed menopause * any condition or situation likely to cause the subject to be unable or unwilling to participate in the study procedures

Keywords: epidermolysis bullosa
effects of low lh serum levels on ovarian pick-up outcome

Conditions: Infertility, Female; ART

Summary: luteinizing hormone (lh) plays a key role for normal follicular development and oocyte maturation in controlled ovarian stimulation. in particular, lh stimulates the proliferation and differentiation of theca cells for the secretion of androgens, which synergistically increase the production of estrogen. this study aimed to investigate the effects of low lh concentrations on oocyte retrieval, fertilization and embryo development in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi). patients undergoing ivf/icsi were prospectively analyzed, subdividing them into three groups according to their age. serum lh levels were evaluated at day 3, during stimulation (day 10) and before ovulation induction (day 12).


Eligibility criteria:
inclusion criteria: age between 18 and 40 years, body mass index 18-29 kg/m 2 , regular menstrual cycles, normal uterine cavity assess by hysteroscopy, normal uterus and ovaries at transvaginal sonography, exclusion criteria: abnormal cervical cytology, affected by any other endocrinological, metabolic, autoimmune, and gynecological disease.

Keywords: embryo quality lh levels oocyte retrieval
rubber hand illusion in anorexia nervosa

Conditions: Anorexia Nervosa

Summary: the present research project aims to verify a possible difference in the recalibration of the real hand position (i.e. proprioceptive drift) in relation to the dimensions of the plastic hand in the rubber hand illusion, among a group of female participants with anorexia nervosa compared with a normal weight control group.


Eligibility criteria:
inclusion criteria: * right-handed * diagnosis of anorexia nervosa according to the apa criteria exclusion criteria: • concurrent neurological, neurodevelopmental (e.g., autism), motor, somatosensory and/or psychiatric disorders.

Keywords: bodily illusion body representation
evaluation of efficacy of photodynamic therapy in basal cell carcinoma

Conditions: Basal Cell Carcinoma

Summary: the purpose of this study is to evaluate the efficacy of pdt in treatment of bcc and factors that affect response rate.

background and aim: basal cell carcinoma (bcc) is the most common skin cancer .photodynamic therapy _as a novel , non-invasive therapeutic approach _may be considered a valuable strategy. this study was designed with the aim of the evaluation of efficacy of pdt in treatment of bcc and factors that may affect response rate. materials and methods: this was a clinical trial which was done on 28 bccs. patients were treated with ala-pdt monthly for 1-6 sessions and evaluated for clinical response,cosmetic results and probable side effects.

Eligibility criteria:
inclusion criteria: * histologically proven bccs exclusion criteria: * rodent ulcer * morphea type * ana + * history of photosensitivity or photodermatosis or ingestion of phototoxic drugs during last month * pregnancy * breast feeding * age\< 18 * history of another therapeutic intervention for bcc during last 6 months

Keywords: basal cell carcinoma photodynamic therapy photo chemotherapy basal cell epithelioma
realmove (lung): assessing tumour motion with dynamic mri

Conditions: Lung Tumor

Summary: the study aims to develop an improved method to tailor the geometric safety margin when treating with stereotactic body radiotherapy (sbrt), to avoid tumour cells being missed during irradiation and to limit the exposure of normal tissues as much as possible. dynamic magnetic resonance imaging (mri) is assumed to represent the tumour motion during the respiratory cycle more realistically, compared to 4-dimensional computed tomography (4d ct), thanks to its high temporal resolution and the possibility to image the motion over a longer period of time. patients receiving sbrt for a pulmonary target located below the level of the carina are included in the study, and the hypothesis will be tested through a comparison of the tumour amplitude measured with each modality. furthermore, the predictive value of the image series acquired at treatment planning, for the motion patterns observed at each treatment fraction, will be evaluated through repeated 4d cbct acquisitions.

in the current study, a 2d-cine mri examination will be performed, in addition to the 4d ct examination that is standard for patients receiving radiotherapy for tumours in the thorax or abdomen. a subgroup of the study participants (referred to as the 4d cbct subcohort) will also be required to perform a 4d cbct examination at three treatment sessions. the main cohort consists of 95 subjects and the 4d cbct subcohort of 55 subjects. the study does not involve any change in the treatment routine; rather, the study images are collected for retrospective analysis. following each imaging session, the subject should fill out an anxiety questionnaire and their pulse will be measured, to give an indication of any anxiety which might influence the breathing pattern of the current session. clinical follow-up will be performed retrospectively by reviewing the participants' medical records. progress, health status and treatment-related toxicity will be evaluated, up to 10 years after completed treatment. the study objectives are: * to evaluate dynamic mri for characterising the respiratory-related tumour motion, compared to the current standard modality of 4d ct. * to evaluate the variation in breathing motion at different times points. * to evaluate the clinical outcome.

Eligibility criteria:
inclusion criteria: * accepted for sbrt treatment of one or more caudally situated lung targets (nsclc or metastases), i.e. below the carina. * age ≥ 18 years * adequate clinical condition to maintain immobilised position for at least 30 minutes * adequate swedish skills and cognitive function to understand study information and to fill in the questionnaire exclusion criteria: * pregnancy or breastfeeding, or planned pregnancy or breastfeeding, during treatment * contraindication for mri examination * otherwise incapable of participating in study

Keywords: radiotherapy motion management dynamic mri
one team: changing the culture of youth sport with pregame safety huddles

Conditions: Concussion, Brain

Summary: randomized controlled trial of a behavioral intervention (pre-game safety huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.

more than 1 million youth sustain a sport-related concussion (src) each year. the middle school age range is particularly concerning because it is a time when children have both a unique susceptibility to brain injury and high participation rates in organized sports with concussion risk, such as soccer and football. there are two avenues to decrease concussion risk: (1) minimizing the number and force of collisions to decrease concussion incidence (primary prevention) and (2) improving concussion identification to decrease morbidity (secondary prevention). the goal of this study is to utilize pre-game safety huddles to discuss sportsmanship (primary prevention) and concussion reporting (secondary prevention) with a goal of improving concussion safety. to assess the efficacy of pre-game safety huddles as a tool for injury prevention, we will conduct a randomized controlled trial with youth sport teams. we will recruit leagues in the seattle area (girls' soccer, boys' soccer and football) and randomize them to either intervention or control. coaches in the intervention group will then be trained to lead pre-game safety huddles before each game over the course of the season (9-12 weeks). youth and coaches will be surveyed at three time points and data will be analyzed to determine impact of the intervention on two outcomes: 1) expectations regarding reporting concussive symptoms (cr-e) and 2) expectations regarding engaging in potentially injurious play (ip-e).

Eligibility criteria:
inclusion criteria: * participating on a team in one of the recruited leagues and willing to complete surveys exclusion criteria: * not willing to complete surveys

Keywords: soccer football injury prevention concussion education huddles primary prevention secondary prevention behavioral intervention
transcranial magnetic brain stimulation to reduce cannabis use in heavy cannabis users

Conditions: Cannabis

Summary: the growing legalization of cannabis across the u.s. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (cud). while there are several medications being investigated as treatment options for cud, none have been fda-approved, and there is limited efficacy of traditional behavioral therapy approaches for this population. consequently, there is a pressing need for the development of new treatments, including approaches that specifically target the brain areas associated with problematic cannabis use behaviors. elevated attention to drug cues is one of the primary causes of relapse in heavy cannabis users. preliminary data suggests that transcranial magnetic stimulation (tms), a non-invasive form of brain stimulation, may be a novel brain-based tool to decrease heightened attention to drug cues in people with cud. building on prior data, the primary goal of this study is to evaluate the feasibility and effectiveness of tms as a tool to decrease attention to drug cues and reduce cannabis use. this study will evaluate whether 2 weeks of rtms can be used to decrease attentional bias to cannabis cues and reduce cannabis use in heavy cannabis users. we will recruit sixty (60) non-treatment seeking, near-daily cannabis users to receive 10 daily sessions of either real or sham (aka placebo) rtms over a 2-week period. participants will live on a residential research unit for 3 weeks. during the residential stay, data on cannabis use (measured using standard human laboratory measures of choice to smoke cannabis) and relevant brain activity (measured using drug cue exposure fmri tasks) will be collected before and after the course of 10 daily rtms sessions. we will aim to show whether real rtms treatment reduces brain response and attentional bias to cannabis cues and reduces cannabis use levels.


Eligibility criteria:
inclusion criteria: * males/non-pregnant females, 18-60 years old * current cannabis user * able to perform all study procedures exclusion criteria: * use of other illicit drugs * if medical history, physical and psychiatric examination, or laboratory tests performed during the screening process reveal any significant illness that the study physician deems contraindicated for study participation

Keywords: cannabis self administration transcranial magnetic stimulation repetitive transcranial magnetic stimulation intermittent theta burst stimulation functional magnetic resonance imaging functional neuroimaging functional brain imaging marijuana cannabis smoking marijuana smoking recreational marijuana use stroop task attentional bias drug cue reactivity intervention treatment double blind sham sham controlled residential inpatient ecological momentary assessment randomized controlled clinical trials randomized clinical trials neuronavigation personalized cortical targeting biomarker development brain mapping neuroendophenotypes neurobiomarkers
mitral valve reconstruction in chronic heart failure (chf): identification of predictors for a successful therapy

Conditions: Chronic Heart Failure; Mitral Insufficiency

Summary: the aim of the study is to evaluate hemodynamic and echocardiographic parameters in patients with secondary mitral insufficiency and chf. 1. identification of hemodynamic parameters as predictor for a successful mitral valve reconstruction in chf patients. 2. collection of clinical factors for the assessment of the postoperative course after mitral valve reconstruction in chf patient.


Eligibility criteria:
inclusion criteria: 1. age \> 18 years old 2. dilatative cardiomyopathy with lvef \< 35% 3. nyha iii oder iv under maximal medical treatment 4. angiographic and hemodynamic mi \> ii° (lap- mean pressure \> 15-20 mmhg; la v-wave-oder pcwp v-wave \> 35 mmhg under exercise) 5. echocardiographic mi \> ii° 6. at least 1 hospitalization for heart failure before op exclusion criteria: 1. secondary cardiomyopathy by vitium cordis 2. planned secondary procedure like cabg, aortic valve surgery, surgery of the tricuspid valve etc 3. inclusion in another trial 4. euro-score \> 30% 5. former valve operation or cabg

Keywords: chf mitral insufficiency conductance catheter mitral valve repair
quantitative mri for non-invasive assessment of severity of alcoholic liver disease (ald)

Conditions: Alcoholic Liver Disease

Summary: the current goal in the treatment of alcoholic liver disease (ald) is to manage ald-associated complications as there are no disease-specific therapies. identifying disease-specific therapies to slow ald progression is critical to improving the outcomes in these patients. despite preclinical treatment studies in animal models that have shown promise, clinical trials in ald patients have been limited by the absence of sensitive, quantitative methods for identifying severity and monitoring progression of liver disease. the rates of progression of liver disease in ald are variable and difficult to predict, which makes assessments of therapies difficult. clinical measures of hepatic or biliary disease (e.g., bilirubin, transaminases) may be normal, only mildly elevated and/or stable despite ongoing organ damage. liver biopsies are diagnostic, but are invasive and are of limited value for longitudinal monitoring. currently clinical imaging, including standard volumetric imaging (mri and ultrasonography) and hepatic fibrosis assessment (e.g. fibroscan) are also of limited utility in fully staging disease severity and monitoring progression in ald. the absence of clinically available methods for accurately determining the severity and progression of liver disease progression in ald has limited implementation of clinical trials using novel therapeutic agents. development of non-invasive imaging biomarkers to assess rates of liver progression will overcome this barrier and allow for such studies to be undertaken. this study intends to perform a one-time mri on patients with ald to search for these biomarkers that can improve the diagnosis and treatment of ald patients.


Eligibility criteria:
inclusion criteria: * all subjects \> 18 years of age, with the clinical diagnosis of ald and native liver will be eligible exclusion criteria: * subjects with history of combined organ transplantation * presumed or biopsy-confirmed ascending cholangitis within the last 3 months * contraindications for mri (e.g. pacemakers, implants/hardware that is not mri compatible)
risk-based screen and prognostic analysis for second primary malignancies in kidney cancer patients

Conditions: Kidney Cancer

Summary: second primary malignancy (spm) significantly impacts the survival and prognosis of patients. this study endeavors to identify risk and prognostic factors associated with spm after first primary kidney cancer and construct predictive nomograms.

in recent years, with the advancement of cancer treatment techniques and the prolonged survival of patients, the prevalence of second primary malignancy (spm) has been escalating, emerging as a significant health issue among cancer survivors. the goal of this study is to identify risk and prognostic factors associated with spm after first primary kidney cancer and construct nomograms to provide clinical evidence. the main questions this study aims to answer are: (1) what are the risk factors associated with the prevalence of spm after kidney cancer? (2) what are the prognostic factors associated with the overall survival (os) of kidney cancer patients with spm? (3) how to accurately predict the probability of developing spm after kidney cancer and the os of kidney cancer patients with spm? in this retrospective population-based cohort study, patients diagnosed with first primary kidney cancer between 2000 and 2020 were retrospectively enrolled from the surveillance, epidemiology, and end results (seer) database. researchers will concentrate on the risk and prognostic factors of spm after kidney cancer, and develop nomograms to forecast the development and overall survival (os) of spm after kidney cancer.

Eligibility criteria:
inclusion criteria: * (1) diagnosed age was between 18 and 80 years old * (2) diagnosed histologically confirmed as first primary kidney cancer * (3) the staging of kidney cancer was early or localized advanced (t1/2/3n0m0) * (4) detailed survival data and follow-up information should be provided exclusion criteria: * (1) histological conformation for diagnosis was unavailable * (2) the type of reporting source was "death certificate only" or "autopsy only" * (3) patients with other malignancies before the diagnosis of primary kidney cancer * (4) the staging of kidney cancer was not early or localized advanced (t1/2/3n0m0) * (5) diagnosis interval between first primary malignancy (fpm) and second primary malignancy (spm) was less than 6 months * (6) the information was not complete

Keywords: kidney cancer prediction model prognosis risk factors second primary malignancy