Kornimate/medical-research-clean huggingface dataset:
dorsal penile block for post-robotic prostatectomy foley discomfort

Conditions: Prostate Cancer; Robotic Prostatectomy; Foley Catheter Discomfort

Summary: the indwelling urethral foley is a major source of discomfort following radical prostatectomy. our hypothesis is that intra-operative dorsal penile nerve block with bupivacaine may decrease immediate post-operative foley discomfort.

patients undergoing robot-assisted radical prostatectomy (rarp) will be randomized in a double-blind placebo controlled manner to undergo penile ring block injection at the time of skin incision closure. a visual analog scale (vas) based questionnaire including newly developed foley discomfort scores will be administered at various time points post-operatively.

Eligibility criteria:
inclusion criteria: * age 40 years and above, * diagnosis of prostate cancer, * electing to undergo robot-assisted radical prostatectomy exclusion criteria: * allergy to bupivacaine or amide-type local anesthetics, * chronic pain condition, * recently or currently on narcotics, * genital abnormalities

Keywords: randomized trial robotic prostatectomy prostate cancer foley catheter discomfort
quantification of the time and effort required for peripheral blood stem cell collection -the european perspective

Conditions: Lymphoma

Summary: this study aims to observe the effects of the availability of plerixafor on the time and effort associated with autologous peripheral blood stem cell collection.

this non interventional study will consist of two parts: i. retrospective study: a medical record review will be conducted covering 200 patients file undergoing peripheral blood stem cell mobilization in some european centers. ii. prospective study :time/motion evaluation of actual apheresis - 20 events each center the actual apheresis events will be measured in consecutive patients scheduled to be candidates for peripheral blood stem mobilization in the apheresis area of the hospital. each apheresis will be considered as one event . should the patient receive more than 1 apheresis, each apheresis will be considered as one different event.

Eligibility criteria:
inclusion criteria: patients must satisfy the following for the part 1 * oncology patients diagnosed with non-hodgkin lymphoma who are candidates for autologous hematopoietic stem cell transplantation (hsct) * a patient that fails to achieve a target cd34+\>20 cells/µl, before or on the first day of apheresis * age \> 18 years exclusion criteria for the part 1 patients with: * age \< 18 years; * primary diagnosis other than non-hodgkin lymphoma * undergone prior autologous hematopoietic stem cell transplantation (hsct)
vitamin d and cardiac autonomic tone in hemodialysis

Conditions: Cardiovascular Disease; Sudden Cardiac Death

Summary: despite advances in treatment of conventional cardiovascular risk factors, patients with kidney disease remain at high risk for fatal cardiac events. to date, kidney disease affects approximately 2 million canadians; however, this patient population remains grossly understudied due to the complex nature of the disease. the inadequacy of the literature to address the cardiovascular-related mortality rates in those with kidney disease reflects the urgent need for investigation of novel risk factors. one cardiovascular risk factor which has recently been validated is the clinical measurement of cardiac autonomic tone (cat). cat refers to the amount of activity contributed by the stimulatory and inhibitory limbs of the cardiac autonomic nervous system, which work in concert with one another to control heart rate. cat can be quantified computer analysis of heart rate over time, captured by a simple holter electrocardiogram (ecg) recording. abnormal cat, which occurs when the autonomic system does not control heart rate properly in response to physical demands or stress, is associated with risk of adverse cardiovascular events in both healthy and high risk populations. it has recently been shown that patients with severe kidney disease demonstrate significant cat abnormalities, thus exaggerated susceptibility to cardiac death. vitamin d (vd) deficiency is also common in this patient population due to the fact that the kidney plays a crucial role in vd metabolism. given that vd deficiency is an established cardiovascular risk factor on its own, it is possible that kidney disease patients experienced compounded risk due to the combination of vd deficiency and abnormal cat. however, no study has ever investigated whether vd deficiency influences cat in healthy or diseased populations. to our knowledge, this will be the first trial to ever examine the effect, if any, of different vd supplementation treatments (standard of care vs. combination) on cat in a population burdened with overwhelming risk and incidence of cardiovascular and sudden cardiac death risk.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * 3x weekly hemodialysis outpatient within calgary for at least 3 months prior to enrolment * physician consent to participate in vd supplementation regimen * ability and agreement to cease any vd medication for 4 weeks prior to initiation of study * able to comprehend study and provide oral and written consent in english exclusion criteria: * any major cardiovascular event (new onset arrhythmia, hospitalization for a cardiac event) noted in patient chart within the 6 month period prior to initiation of the study * currently on vd therapy/refusal to cease vd therapy for 4 weeks prior to initiation of study * physician anticipates death or adverse event within the next year- known discharge from hemodialysis (transfer to peritoneal dialysis, kidney transplant)

Keywords: vitamin d hemodialysis sudden cardiac death heart rate variability cardiac autonomic tone
the relationship between aldh2 and aortic dissection

Conditions: Aortic Dissection

Summary: the purpose of this study is to evaluate the impact of aldh2 glu504lys polymorphism on aortic dissection.


Eligibility criteria:
inclusion criteria: * chinese han people diagnosed with aortic dissection in qilu hospital exclusion criteria: * aortic dissection based on trauma, connective tissue diseases and pregnancy * patients with tumor * patients with no written consensus

Keywords: aortic dissection aldehyde dehydrogenase 2 polymorphism risk factor aldehyde dehydrogenase 2
clinical effect of individualized exercise prescription for hypertension with 6-minute walking test (6mwt)

Conditions: Hypertension

Summary: obesity and lack of exercise are one of the reasons for high blood pressure. exercise can reduce the risk of cardiovascular events by reducing weight and blood pressure. the precise formulation of exercise prescription by cardiopulmonary exercise test (cpet) can effectively control hypertension. our research group has formulated 50 "exercise prescriptions for hypertension population" in the early stage, but how to further effectively implement them needs to be discussed. based on the previous experience of undertaking the project "exercise prescription for hypertensive people" of general administration of sport of the people's republic of china, this research group discussed the important role of intelligent information management in the clinical effect evaluation and effective implementation of exercise prescription for hypertension; to explore the feasibility of making exercise prescription for hypertension based on 6-min walking test, and whether it is not inferior to or equivalent to the accuracy and effectiveness of making exercise prescription by cpet. the relevant results will lay a foundation for exploring the broader adaptation of hypertension exercise prescription to the population.

the 6-minute walking test (6mwt) has good universality and accessibility, and can be used as the basis for formulating exercise prescriptions. according to the consensus of chinese experts on the application of clinical norms of the six-minute walking test, it is recommended to formulate individualized exercise prescriptions based on the average walking speed of 6mwt calculated from the six-minute walking distance (6mwd), but there is no relevant content about hypertension.

Eligibility criteria:
inclusion criteria: * overweight/obesity; normal or normal high blood pressure after drug use; grade 1 hypertension (whether taking medicine or not); having sports habits; sports risk is low and medium exclusion criteria: * ≥ grade 2 hypertension; high-risk hypertensive patients; malignant hypertension, secondary hypertension, etc; serious arrhythmia, heart failure, acute myocardial infarction; severe stroke, liver and kidney insufficiency; physical dysfunction and failure to cooperate for various reasons; unable to conduct cpet; the types and doses of antihypertensive drugs is still in the process of adjustment

Keywords: hypertension exercise prescription intelligent information management 6-min walking test (6mwt) cardiopulmonary exercise test (cpet)
fmri and ghlrein in obesity and binge eating disorder

Conditions: Obesity; Binge Eating Disorder

Summary: binge eating disorder (bed) may be associated with he development of obesity. however, the pathogenesis of bed is currently unclear, thus making the development of treatment and prevention strategies for bed difficult. differences in the mechanisms regulating food intake may go some way to reveal potential mechanisms for bed.the purpose of this study is to investigate the responses of key gut-derived hormones that are associated with the regulation of food intake and functional brain activity to food cues using fmri in bed patients and weight matched controls.

participants will attend the laboratory on two separate occasions following an overnight fast. following baseline measures they will be provided wither with a 600ml (600kcal) liquid meal (fed condition) or a volume matched amount of plain water (fasted condition) to consume within 15 min in a randomized crossover design. blood samples will be collected for during the subsequent 120min to measure the glucose, insulin and gut hormone responses, and subjective appetite ratings will be collected. 1500mg of acetaminophen will be added to each of the test drinks so that the appearance in the blood can be used as a proxy measure of gastric emptying. participants will then undergo a 45min brain scan to assess the responses to visual and auditory food cues.

Eligibility criteria:
inclusion criteria: * age 18-65 years * bmi 30-50 kg/m2 * weight stable (\<5% change in body weight during past 3 months) * right handed exclusion criteria: * smokers * regular use of medications * current or intended participation in a weight-loss program (diet or exercise) * females who are pregnant or lactating

Keywords: obesity binge eating disorder fmri gut hormones
packaging prep to prevent hiv among wwid

Conditions: HIV/AIDS

Summary: evidence suggests women who inject drugs (wwid) are disproportionately vulnerable to hiv. if hiv incidence continues unchecked, 1 in 23 wwid in the united states will acquire hiv. this observational study will evaluate a novel approach for the delivery of pre-exposure prophylaxis (prep) care: pairing prep with community-based syringe exchange program (sep) services. the rationale is that (1) seps may currently provide prescription medications and long-term monitoring for other conditions such as buprenorphine for opioid dependence, so providing prep care is a natural extension of what is already being done successfully; (2) seps are a viable access point for many hiv-uninfected wwid who would be considered eligible for prep under current clinical guidelines; and (3) prep interventions, delivered in settings already utilized and trusted by wwid, will increase uptake, adherence and retention in prep. we will enroll a cohort of 125 women and follow-them over six months. at their first study visit, they will educated about and offered a prescription for prep. those who indicate an interest in prep will be able to return to the sep one week later to obtain a paper prep prescription or medication. all participants will be followed for six months using qualitative interviews and surveys to understand facilitators and barriers to prep uptake and engagement over time. in addition, we will collect urine and test it to detect the level of drug concentration among women who initiate prep. this will allow us to know whether their level of adherence translated to prevention effective drug levels.

this prospective mixed methods study will be initiated within the largest sep in the mid-atlantic region. over six months, we will use semi-structured and in-depth interviews based on the behavioral model for vulnerable populations, and drug-level monitoring for emtricitabine (ftc)/tenofovir disoproxil fumarate (tdf) adherence, to address the following specific aims: (1) describe wwid's engagement in the prep care continuum (focusing on critical moments when women could disengage or need additional support to remain in care). (2) identify factors from the behavioral model for vulnerable populations that are associated with wwid's engagement in the prep care continuum. (3) explore how and why model factors are associated with wwid's decisions and ability to engage in prep care. a paired model of prep and sep services has yet to be tested.

Eligibility criteria:
inclusion criteria: * hiv sero-negative * females * age ≥18 years * reporting non-prescription injection drug use and any of the following: 1. syringe sharing 2. injecting drugs with a hiv-positive partner 3. recent opioid agonist treatment but still injecting drugs 4. sex exchange 5. inconsistent condom use 6. recent bacterial sexually transmitted infection (sti) 7. and/or sex with a hiv-positive partner exclusion criteria: * hiv seropositivity * currently taking prep * pregnant, breastfeeding or trying to become pregnant * previous enrollment in the study

Keywords: pre-exposure prophylaxis injection drug use
dexamethasone and etoricoxib for pain prevention following periodontal surgery

Conditions: Pain Control

Summary: the purpose of this study is to investigate whether preemptive medication with dexamethasone or etoricoxib provides better pain management and control than placebo following periodontal surgery.


Eligibility criteria:
inclusion criteria: * patients presenting moderate or severe periodontitis after nonsurgical periodontal treatment with clinical signs of inflammation exclusion criteria: * pregnant * diabetes mellitus * heart diseases * allergic to components of the medications * risk of endocarditis

Keywords: pain pain assessment
oscillating positive expiratory pressure (opep) therapy in trauma patients with multiple rib fractures

Conditions: Rib Fractures; Respiratory Complication

Summary: to determine the efficacy of oscillatory positive expiratory pressure (opep) therapy on patients admitted through the trauma service line for rib fractures, as compared to incentive spirometry (is).

patients identified through screening procedures to fit the inclusion criteria will be approached, within 48 hours of floor admission, to participate in the study. once written informed consent is obtained, participants will be randomized, in a 1:1 ratio, into either the is or opep study group. each patient will be instructed on how to use the respiratory therapy device, either is or opep, by research personnel and respiratory therapists. participants will be instructed to record their compliance with the rt protocol in their respective patient diaries. respiratory therapy will record fvc three times daily on all study participants until stable (fvc \> 1.5l x 4), then daily for up to 7 days or until discharge. participants will be contacted on day 30 from discharge, and administered a short questionnaire. all participants will be followed and monitored per standard of care, under the care and supervision of their treating provider teams.

Eligibility criteria:
inclusion criteria: * greater than or equal to 18 years old * greater than or equal to 1 rib fracture * admitted to trauma services at medical center of the rockies (mcr). exclusion criteria: * less than 18 years old * any physical injury that creates inability to functionally use devices * adults unable to consent or cooperate due to * dementia * confusion * on ventilator support * moderate to severe traumatic brain injury (glasgow coma scale \< 12) * cervical spinal cord injury * women who are pregnant
decoding the association of imaging and tumor microenvironment in lung cancer using radiogenomic approach（radiogenomics-lung）

Conditions: Lung Cancer

Summary: this is the prospective, observational cohort study (radiogenomics-lung), which aims to explore the relationship between the imaging information of lung cancer patients, tumor microenvironment and the prognosis of lung cancer patients.


Eligibility criteria:
inclusion criteria: 1. patients were treated for lung cancer in wuhan union hospital from july 2024 to july 2027; 2. aged \> 18 years old; 3. at least one chest ct scan before treatment; 4. tissue biopsy pathological examination confirmed the diagnosis of the above tumors. exclusion criteria: 1. poor image quality; 2. incomplete clinical data or loss of follow-up; 3. presence of another primary malignancy other than lung cancer; 4. unclear pathological diagnosis。
at goal: adopting technology for glucose optimization and lifestyle in pregnancy

Conditions: Type2Diabetes; Pregnancy in Diabetic

Summary: this study will assess differences in patient preferences and glucose control between continuous glucose monitoring and standard glucose checks in pregnant patients with type 2 diabetes. 40 participants will be on study for approximately 182 days (26 weeks).

this pilot single site randomized control trial will compare the blood glucose control and participant satisfaction scores of continuous glucose monitoring vs standard glucose checks in pregnant women with a prior diagnosis of type 2 diabetes. the study population will consist of 40 women who are less than 20 weeks pregnant at time of enrollment who have a pre-pregnancy diagnosis of type 2 diabetes. participants will be randomized to one of two treatment arms. * arm 1: placement of dexcom g6 continuous glucose monitor for glucose monitoring for duration of pregnancy * arm 2: continuation of standard glucose finger sticks with placement of a blinded dexcom pro g6 continuous glucose sensor for two ten day periods (at enrollment and again at 28-32 weeks gestation) participant accrual will occur over 18 months at 1 site. participants will complete 3 study visits, all of which will be in conjunction with previously scheduled prenatal or diabetes visits: at the time of consent (less than 20 weeks gestation), 28-32 weeks gestation, and 2-6 weeks postpartum.. surveys will be administered at each time point. at the final visit, patients will be asked for participate in a 2-5 minute directed interview as well. * primary objective * to examine the feasibility of completing a study to assess for differences in patient preferences and glucose control between continuous glucose monitoring and standard glucose checks in pregnant patients with type 2 diabetes. * secondary objectives * to estimate the effect of continuous glucose monitoring devices placed prior to 20 weeks in pregnancy in patients with type 2 diabetes on time in range, as measured between 28-32 weeks of pregnancy. * to assess patient satisfaction to continuous glucose monitoring during pregnancy * to estimate the effect of continuous glucose monitoring on the incidence of neonatal morbidity and mortality.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years of age at enrollment * ability to consent in english * gestational age less than or equal to 19 weeks 6 days at enrollment * appropriate dating by certain lmp or ultrasound performed less than or equal to 19 weeks 6 day * diagnosis of type 2 diabetes less than or equal to 19 weeks 6 days * singleton gestation exclusion criteria: * age less than 18 years of age at enrollment * lack of appropriate dating * multiple gestations * use of concentrated insulin at enrollment (ie u500) * preexisting cgm in place * chronic use of medications known to cause hyperglycemia, such as hiv antiretrovirals and inhaled, injectable and oral corticosteroids * be unwilling or unable to present to center for perinatal care for visits
non interventional study (nis) regarding the application of ectoin mund- & rachenspray in patients with acute laryngitis and/or acute pharyngitis

Conditions: Acute Pharyngitis; Acute Laryngitis

Summary: in this observational study insights regarding the tolerability and influence on the quality of life of the topical treatment ectoin mund- and rachenspray compared to emser pastillen in patients with acute pharyngitis/ laryngitis under real life conditions shall be gained. patients are treated with ectoin mund- \& rachenspray 1% or emser pastillen according to the demands of the physician and the instructions for use.


Eligibility criteria:
inclusion criteria: * patients with acute laryngitis and/or pharyngitis which are already treated with ectoin mund- \& rachenspray 1% or emser pastillen exclusion criteria: * contraindications according to instructions for use