Kornimate/medical-research-clean huggingface dataset:
transurethral prostate resection (turp) vs. prostate artery embolization (pae)

Conditions: Transurethral Resection of Prostate Syndrome; Prostate Hyperplasia; Embolization, Therapeutic

Summary: this study focuses on the treatment of benign prostatic hyperplasia which causes lower urinary tract symptoms. the purpose of the research project is to evaluate pae in terms of both medical and health economic outcomes. to evaluate whether there are any differences in effect (ipss), complications, costs and perceived quality of life compared with tur-p.


Eligibility criteria:
inclusion criteria: * benign prostatic hyperplasia where medical treatment has not helped or for other reasons has not been deemed applicable * ipss\>=8 * prostate volume \[40-80\] ml measured via transrectal ultrasound * peak flow rate (qmax) \<= 15 ml / s, * verified obstruction by urodynamic studies (cystometry) * surgery not contraindicated exclusion criteria: * prostate cancer * severe atherosclerosis * kidney failure * urethral stricture * active cystitis or prostatitis * bladder stone. * neurogenic bladder disorder * contrast product allergy

Keywords: prostate embolisation pae
evaluation of the neonatal autonomic stress during intubations under propofol in a population of premature infants under 33 w'ga

Conditions: Hyaline Membrane Disease; Preterm Infant

Summary: hyaline membrane disease is one of the leading causes of morbidity and mortality in premature newborns in industrialized countries. for 30 years, the management of the hyaline membranes disease has been transformed by intratracheal administration of exogenous surfactant (curosurf®) at birth or in the following hours. in order to limit the harmful effects in terms of barotrauma of mechanical ventilation, several methods have been developed over the last decades, aiming at limiting the mechanical ventilation to the profile of non-invasive ventilation: thus the administration of surfactant has become faster (although invasive) and if possible followed by immediate extubation following the insure (intubation / surfactant / extubation) or lisa (less-invasive surfactant administration) procedure. given the fragility of the children concerned and their low weight, this invasive gesture has long been carried out without premedication. however, taking into account the pain induced and potential hemodynamic consequences of the gesture, neonatal societies now recommend the use of anesthetic before intubation, with a short duration sedative. propofol is a general anesthetic that combines these conditions and is widely used in pediatric anesthesia. in that way, since 2016, the invetigators have modified the sedation protocol for intubation in our department and have recommended propofol as first-line treatment for term and preterm newborn. a lot of study showed its hemodynamic safety in preterms. however, the investigators lack data on the autonomic stress really observed during intubation in this population. the investigators therefore propose to evaluate these physiological data in a non-randomized prospective observational study in premature infants under 33 weeks of gestational amenorrhea (ga), during a sedation protocol for intubation and surfactant administration according the insure or lisa technique, with standardized doses of propofol : 1mg/kg for preterm infants with a birthweight less than 1.5kg and 1.5mg/kg for higher birthweight.


Eligibility criteria:
inclusion criteria: * breathing rate \> 60 cycles/min * silverman scale \> 3 and \< 6 * fio2 \> 30% and \< 60% * collected consent from parents exclusion criteria: * preterm neonates with intraventricular hemorrhage grade iii \& iv * preterm neonates with hemodynamic instability * preterm neonates with congenital heart disease * preterm neonates with severe congenital malformation * preterm neonates already sedated and/or under invasive mechanical ventilation * fio2 \> 60% * silverman scale \> 6 * use of amines for maintaining blood pressure * use of sedatives or analgesics during the last 24 hours (except paracetamol and ibuprofen)

Keywords: insure (intubation / surfactant / extubation) lisa (less-invasive surfactant administration) surfactant propofol
effects of virtual reality-based balance training on balance of diabetic peripheral neuropathy patients

Conditions: Diabetic Peripheral Neuropathy

Summary: the study aimed to clarify the effect of virtual reality-based balance training on balance in patients with diabetic peripheral neuropathy compared to conventional physical therapy.

a randomized control trial will be conducted at the study setting safi hospital faisalabad after the approval of the synopsis. the study will be a single-blinded randomized control study. a convenient sampling technique will be used for the enrollment of the patient. patient selection will be done based on defined insertion and omission criteria. two groups would be made, the intervention group would receive the virtual gaming exercise tutoring and the control group would receive the regular physiotherapy exercises. the evaluation of the patients will be done at the start of the study, after six weeks, and after twelve weeks. follow-up will be in the 16th weeks after the cessation of therapy. the patient's outcome will be measured on berg balance scale and the single leg stance test and the patient's data will be recorded before and after treatment, comparisons between before the treatment and after the treatment data will be made after 12 weeks. informed consent/approval would be taken from each patient. analysis and entry of data will be done by statistical package of social sciences version 22 software.

Eligibility criteria:
inclusion criteria: * adults age (45-65 years) * male and female (both gender) * medical diagnoses of type-ii diabetes * dpn confirmed by physician * stages ( ia - sign but no symptoms of neuropathy, ib - symptomatic mild diabetic poly neuropathy, sensory, motor or autonomic symptoms; patient able to heel walk) * patients independent in transfer. * unimpaired cognition/intelligence (mini mental state examination score of \>24) exclusion criteria: * any neurological diseases e.g. dementia, parkinson, stroke * severe visual impairment and cardiopulmonary disease * musculoskeletal disorder, any disease due to individual were unable to walk and lower limb amputation * disease which has chances of falling

Keywords: virtual reality balance training balance diabetic peripheral neuropathy randomized control trial
the treatment effect for asymptomatic common bile duct stone

Conditions: Choledocholithiasis; Asymptomatic Condition; Quality of Life

Summary: this study is prospective, multicenter study for identify the characteristics of asymptomatic common bile duct stones and effectiveness of treatment.

there is no conflcts for treatment of symptomatic common bile duct stone. as more imaging examination such as healthy screening, more asymptomatic common bile duct stone patients are found. current guideline for aymptomatic common bile duct stone is removal using endoscopic retrograde cholangiopancreatography. however, the previous studies that support this guideline included patients who just underwent cholecystectomy and were diagnosed as common bile duct stone. there is no prospective study for identify the treatment effectiveness of common bile duct stone removal in asymptomatic patients who are dignosed in healthy screening. therefore, we are going to find the effectiveness of common bile duct stone removal by comparing questionnarie before and after removal of common bile duct stone in asymptomatic and incidentally found common bile duct stone patients. in addition, we are going to follow up patients who do not want to undergo common bile duct stone removal and find the rate of cholangitis risk. we also want to identify extact complication rate for endoscopic retrograde pancreatocholangiographic procedures in asymptomatic common bile duct stone.

Eligibility criteria:
inclusion criteria: * diagnosed as common bile duct stone by image modality examination * agreement for this study enrollment exclusion criteria: * no definite common bile duct stone by image modality examination * symptomatic patients who complain with fever/abdominal pain that compatible with common bile duct stone related symptom * previously diagnosed as pancreatobiliary malignancy * previously treated by endoscopic or percutaneous treatment for bile duct stones * severe cardio or pulmonary disease * pregnancy or possibility of pregnancy * who do not agree with study enrollment
effectiveness of an adapted physical activity program for subjects suffering from haemophilia

Conditions: Hemophilia; Sports Physical Therapy

Summary: the present study aims to evaluate the modification of functional capacity induced by an adapted physical activity program in subjects with haemophilia. the exercise program used aims to improve joint mobility, muscle strength, static and dynamic balance, motor coordination. the program is structured in 1 hour sessions of 2 days/week and lasts 6 months. the primary endpoint is the change in functional capacity calculated as the difference between the baseline assessment and the 3 and 6 month assessment of the 6 minutes walking test measured with the g-walk (bts bioengineering s.p.a).


Eligibility criteria:
inclusion criteria: * diagnosis of hemophilia a or b; * signature of informed consent; * availability of a medical certificate for non-competitive activities exclusion criteria: * active bleeding * severe joint deformities that prevent exercise * insufficiency of communicative and/or sensory functions so severe that it is impossible to understand or carry out the trainer's instructions (dementia, aphasia, blindness, deafness) * heart failure (nyha class \> 2) * unstable angina * lung disease requiring oxygen therapy * symptomatic peripheral arterial disease * myocardial infarction or hospitalization within the previous 6 months * symptomatic orthostatic hypotension * hypertension in poor pharmacological control (diastolic\> 95 mmhg, systolic\> 160 mmhg) * significant neurological conditions that impair motor or cognitive function
imaging synapses with [11c] ucb-j in the human brain

Conditions: Schizophrenia

Summary: the purpose of this study is to utilize the radioactive positron emission tomography (pet) tracer \[11c\]ucb-j to test the neural synaptic pruning hypothesis of schizophrenia. this imaging method allows for the quantification of synaptic density in the living human brain and has the unprecedented ability to directly examine the synaptic pathology underlying neuropsychiatric disease. the neural synaptic pruning hypothesis posits that a key pathogenic process of schizophrenia is the over-exuberant elimination of neural synapses during development. the confirmation of reduced synaptic density in schizophrenia as evidenced by \[11c\]ucb-j has the potential to lead to a number of ground-breaking clinical innovations, such as laboratory-based diagnostics and prognostics, and novel, disease-modifying treatments.


Eligibility criteria:
inclusion criteria: * 18 - 65 years in age * for sz participants: * on a stable medication regimen for at least two weeks prior to testing * a clinical diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder * able to complete a pet-mr scan without the use of sedation exclusion criteria: * active substance use within three months of testing * iq \< 70 * major medical neurological illness or significant head trauma * pregnancy or breastfeeding * contraindication to mr scanning, including magnetic-resonance incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ * weight \> 350 lbs or a large body habitus that mr scanner cannot accommodate * history of or current claustrophobia * inability to comply with basic study requirements such as following directions and punctuality * for hc participants: * presence of a first degree relative with a psychotic disorder * lifetime diagnosis of major psychiatric illness * for sz participants: * unstable psychiatric symptoms at the time of testing, e.g. acute suicidality, prominent psychosis, or behavioral dyscontrol
secured internet-mediated psychotherapy with psychiatry patients

Conditions: Psychiatric Disorders

Summary: this is the second phase (phase b) of the main project "bank for thoughts", which has the following aims: 1. improvement of software for secured (encrypted and access-controlled) asynchronous text-based communication within health services. (adjustments for use in psychiatry.) 2. open clinical trials with internet-mediated psychotherapy or counselling in out-patient child and adolescent psychiatry. 3. development of indications and precautions for text-based internet-mediated psychotherapy.

this phase (phase b) concentrates on qualitative evaluation of open clinical single case trials using asynchronous internet-mediated text-dialogue for psychotherapeutic purposes. single patients in differing treatment phases, conditions, age and sex categories are interviewed after using internet-contact as a supplementary tool in psychotherapy. their therapists are interviewed as well. the purpose is systematically gathering single-case experiences with the tool, to build a hypothesis for research and preliminary guidelines for experimental clinical use of internet-mediated psychotherapy.

Eligibility criteria:
inclusion criteria: * motivation for e-mail contact * therapist evaluation for suitability exclusion criteria: * paranoia * psychosis * eating disorders * addictive problems * denying or concealing symptoms

Keywords: etherapy supplementary
detemir energy expenditure study

Conditions: Type 2 Diabetes Mellitus; Obesity

Summary: this is a study designed to compare the effects of 2 long-acting insulins, detemir and insulatard, on energy expenditure,weight, fat composition, gut hormone profiles, glycaemic control and fat and muscle gene expression over a 6 month period.


Eligibility criteria:
inclusion criteria: 1. type 2 diabetes 2. treated with metformin 3. already on treatment with a long-acting or intermediate insulin. 4. over 18 years of age, 5. hba1c \> 7.0% 6. bmi 27-40 7. able and willing to perform self-blood glucose monitoring. 8. able and willing to maintain consistent eating habits throughout the entire trial period. 9. able and willing to maintain consistent physical activity level during the entire trial period exclusion criteria: 1. patients on sulphonylureas or thiazolidinediones 2. proliferative retinopathy that has required acute treatment within the last six months. 3. impaired hepatic or renal functions. 4. cardiac problems. 5. uncontrolled hypertension (treated or untreated). 6. mental incapacity, unwillingness or a language barrier precluding adequate understanding or co-operation.
nutritional study of fish oil in skin quality in healthy women

Conditions: Skin Health

Summary: the skin acts as a barrier against the external environment and prevents water loss from the body. aging is a natural process leading to changes in the skin and fish oil has been shown to prevent inflammation, hyperpigmentation and uv-damage. this pilot study will determine skin characteristics after intervention with north atlantic fish oil.

women will be recruited to a placebo or fish oil group and be examined at pre- and post for skin quality parameters such as wrinkles, fine lines and trans-epithelial water loss.

Eligibility criteria:
inclusion criteria: healthy women in the age of 30-65 able to follow the following dietary restriction for 4 months (4 weeks wash-out, 3 months intervention): * do not take omega-3 supplements * do not take supplements containing vitamin a * do not take supplements containing collagen * try to avoid using skin products containing vitamin a * do not undergo skin treatment exclusion criteria: pregnancy or breast feeding known allergy to seafood skin treatment the last 6 months planned skin treatment during the study period -

Keywords: skin inflammation wrinkles trans epithelial water loss fish oil lcmufa
antibacterial properties of silicon incorporated with quaternary ammonium polyethylenimine nanoparticles

Conditions: Carcinoma of Head and Neck

Summary: the aim of this study is to evaluate the antibacterial activity of crosslinked quaternary ammonium polyethylenimine (pei) nanoparticles incorporated at 1-2% w/w in a commercial soft liner material when compared to the commercial soft liner material. the investigators' results in vitro showed a significant delay in bacterial growth. therefore, the investigators assume to have the same delay in vivo- on patients.


Eligibility criteria:
inclusion criteria: * patients post maxillectomy, who are using obturators exclusion criteria: * patients who are not using obturators

Keywords: head and neck carcinoma obturators maxillectomy soft liner nano particles antibacterial properties patients post maxillectomy
securing the immediate perioperative walk: creating and validating a score.

Conditions: Wandering Behavior; Anesthesia

Summary: the aim of this study is to set up a pre and postoperative ambulation score on a population of adult patients and undergoing outpatient surgery operated under locoregional anesthesia and sedation.


Eligibility criteria:
inclusion criteria: * patient over 18 years-old * patient undergoing sedation with or without associated local anesthesia * patient having giver their consent * patient are benefiting from a social protection insurance * patient hospitalized as part of the outpatient for ophthalmologic surgery or upper limb surgery, plastic surgery or surgery for implantation of a vascular access device exclusion criteria: * patient whose surgery is performed on the lower limbs * patient with psychiatric disorders * patient with dementia * patient who has already participated in this same study (ex: cataract the second eye is made a few weeks after the first) * patient's refusal to participate in the study * protected patients: adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision; pregnant, breastfeeding or parturient woman; hospitalized without consent.
bio-signal telemonitoring using electronic textiles in a pediatric population

Conditions: Heart Failure

Summary: there is a need for developing reliable and convenient technologies for telemonitoring of physiological signals such as respiration, cardiac function, and activity level in children and especially for those with heart disease. changing symptomatology causes heart failure patients to seek medical attention in order to be assessed and potentially have medication adjusted or additional testing being undertaken. these frequent clinical encounters affect the quality of life of these children and their parents, as well as being costly for the health care system. a textile based technology for telemonitoring application that is comfortable and accurate in its data collection can help to provide real time information on physiologic parameters. the primary research objective is to determine the feasibility and validity of a textile-enabled sensor system in measuring physiologic variables, or "biological signals", related to cardiopulmonary function in children. the study will include 10 patients with heart failure, and 10 healthy controls.


Eligibility criteria:
inclusion criteria 1. healthy children participants (i.e. without chd or hf) aged between 10 to 18 years with normal electrocardiograms and normal echocardiograms (i.e. screens for familial cardiomyopathy). or 2. patients aged between 10 and 18 years with diagnosed congenital heart disease or cardiomyopathies referred to pediatric cardiology ambulatory clinic at sickkids. exclusion criteria 1. in-hospital patients. 2. patients too ill to participate or perform any activity. 3. patients with fontan/single ventricle physiology circulation. 4. children who are less than 6 months post op from a cardiac surgery as they will have concerns from an activity and wound care standpoint. 5. participants with known allergies to adhesives (as reported by family).

Keywords: pediatric smart device remote monitoring
cocoa and metabolic health in prediabetes

Conditions: Prediabetes

Summary: the purpose of this study is to determine the impact of consuming cocoa on blood glucose levels, glucose metabolism, and other markers of pre-diabetes in overweight and/or obese individuals. our hypothesis is that consumption of cocoa improves insulin sensitivity and glucose metabolism in subjects at risk for developing type-2 diabetes.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) greater than or equal to 25 and less than 40. * have at least one of the following: 1) impaired fasting glucose (ifg) after an overnight fast with plasma glucose concentration between 100-125 mg/dl, 2) impaired glucose tolerance (igt) as identified by the standard oral glucose tolerance test (ogtt) with 2 hour plasma glucose concentration between 140-200 mg/dl following 75 g glucose ogtt, 3) hba1c levels between 5.7-6.4% or 4) considered at risk to developing type 2 diabetes by the american diabetes association risk assessment. if subjects are above the prediabetic range for any of these tests (indicating they may be type 2 diabetic), they will be excluded and referred to their physician. * weight stable (+/-2 kg) for the last 6 months. * sedentary to recreationally active (less than 2 d/wk, 20 min/d). * have a blood pressure that is less than 160/100 mmhg, total cholesterol that is less than 300 mg/dl and a triglyceride concentration of less than 450 mg/dl. exclusion criteria: * past or current history of coronary heart disease, stroke or major cardiovascular disease events, respiratory diseases, endocrine or metabolic diseases (including type 1 and type 2 diabetes), inflammatory bowel disease, cancer, or neurological or hematological disorders that would compromise the study or the health of the subject. * past or current history of gastrointestinal disorders (including lactose intolerance, ulcers, cancer (stomach, intestinal, colon, pancreatic, liver, etc) nash, nafld, cirrhosis, ibd/ibs, celiac disease, etc). * current use of any medication including but not limited to cholesterol lowering medication (including fibric acid derivatives and niacin), antibiotics, immunosuppressive drugs, azole antifungals, non-steroidal anti-inflammatory drugs (nsaids), hormone replacement therapy or antioxidants/supplements. * use of antibiotics, prebiotics, or probiotics within the prior 3 months. * smoking or other tobacco use * habitual consumption of alcohol more than 2 servings/d for males and 1 serving/d for females. * strict vegetarians or vegans, or strong aversions to major food groups that may be part of the controlled diet. * recent surgery * history of alcohol or drug abuse. * pregnant or plan to become pregnant * allergic to either lidocaine or bupivacaine

Keywords: cacao polyphenols prediabetic state blood glucose glucose intolerance diabetes mellitus, type 2 obesity muscle, skeletal endotoxins gut permeability incretins metabolic flexibility
bevacizumab effect on blood velocity

Conditions: Choroidal Neovascularization

Summary: retinal blood flow velocity is affected by bevacizump intravitreal injection. this effect is correlated to treatment success.

the purpose of the study was to carry out a pilot study on the short-term effect of intravitreal bevacizumab (avastin) injection on retinal blood-flow velocity and test whether the short-term haemodynamic changes could predict the longer term clinical result of the treatment.

Eligibility criteria:
inclusion criteria: * patients with cnv receiving bevacizumab intravitreal injection exclusion criteria: * candidates in whom the retina could not be seen clearly because of media opacity or a poorly dilating pupil