Kornimate/medical-research-clean huggingface dataset:
is mitral annuloplasty an effective treatment for severe atrial functional mr?

Conditions: Mitral Regurgitation

Summary: atrial functional mitral regurgitation (mr) is caused by annular dilatation and flattering associated with altered atria/annulus dynamics in patients with severely dilated left atrium and normal leaflets anatomy. inadequate leaflets adaption is considered a mechanistic culprit as well. prevalence of at least moderate atrial functional mr varies between 4.7% and 7% in patients with permanent and long standing persistent atrial fibrillation (af) and is even higher in patients with heart failure with preserved ejection fraction (hfpef). unlike secondary mr in the setting of left ventricular disease, results of surgical treatment of severe atrial functional mr has remained largely unspoken. the aim of this study is to analyze short and mid-term results of isolated annuloplasty in patients with severe, symptomatic atrial functional mr, in comparission to a matched cohort of patients with secondary mr.


Eligibility criteria:
atrial mr group inclusion criteria * adult patients, underwent mitral annuloplasty for atrial functional mitral anatomical criteria * annular dilatation with anterior-posterior diameter (ap) in systole \>35mm * ratio of ap diameter in systole to anterior leaflet length in diastole \>1.3 * normal leaflets anatomy * mild fibrosis may be present * a small cleft may be present as a result of annular dilatation functional criteria * normal leaflet mobility (carpentier type i) * coaptation depth \<10mm * absence of ventricular tethering * centrality of the regurgitant jet atrial and ventricular characteristics * left atrium diameter \> 40 mm * normal systolic function of the left ventricle * mild left ventricular systolic dysfunction mild lv (tachycardia induced) with ef \>45% * absence of regional abnormalities in left ventricular wall motion clinical criteria * persistent, long-standing persistent, or permanent atrial fibrillation exclusion criteria * degenerative mr including congenital clefts * lvef \< 45% * ventricular tethering * coaptation depth \>10 mm * regional abnormalities in left ventricular wall motion * sinus rhythm * presence of coronary artery disease * absence of annular dilatation non-atrial mr group inclusion criteria * adult patients underwent cardiac surgery for non-atrial functional mitral regurgitation in the setting of an idiopathic or ischemic cardiomyopathy exclusion criteria * fe\<40% * concomitant coronary artery bypass graft * age \ 75years * treated with annuloplasty + edge-to-edge surgery * sinus rhythm
effect of back school-based intervention on non-specific neck pain in adults.

Conditions: Neck Pain; Exercise Therapy; Health Education

Summary: the study consists of a theoretical and practical intervention based on the back school. this intervention will be carried out over 8 weeks with a frequency of two sessions per week, for a total of 16 sessions of 45 minutes duration. of all the sessions, 14 had a practical focus (strength and stretching exercises) and the other two had a theoretical focus (self-management techniques and pain neuroscience education). in addition, they had an initial session and a session at the end of the of the intervention in which measurements of the different variables were taken (the visual analogue scale; neck disability index; tampa scale of kinesiophobia).these variables will be measured on two occasions, at the beginning of the study and at the end of the intervention, an average of 2 months. the clinical practice guidelines highlight the importance of neck pain prevention through exercise an education. there are previous studies of the effects of theoretical and practical programmes based on back school on the lumbar region but not on the cervical region. therefore, the aim of this study is to investigate the effects of a bs-based intervention on neck pain and functionality as well as kinesiophobia and quality of life in adults. the hypothesis previously hypothesised that this bs-based intervention would have positive effects on pain, functionality, kinesiophobia and quality of life.


Eligibility criteria:
inclusion criteria: * 18-65 years of age. * with non-specific neck pain for at least three months, with pain intensity (30-70 on a vas). exclusion criteria: * any previous neck or shoulder surgery, fibromyalgia, cervical radiculopathy/myelopathy, history of the whiplash injury, cognitive disorder. * missing more than two back school sessions. * not being able to attend the measurement sessions.
quality of life interventions during cervical cancer treatment

Conditions: Cervical Cancer

Summary: the proposed project will examine the effects of a healing touch intervention in women receiving chemotherapy and radiation for advanced cervical cancer.

patients receiving chemoradiation for cervical cancer are at risk for distress, chemoradiation-related side effects, and immunosuppression. this prospective randomized clinical trial proposes to examine the effects of a complementary therapy, healing touch (ht), versus relaxation training (rt) and usual care (uc) for (1) supporting cellular immunity, (2) improving mood and quality of life (qol), and (3) reducing treatment-associated toxicities and treatment delay in cervical cancer patients receiving chemoradiation.

Eligibility criteria:
inclusion criteria: * women with stage i-iva cervical cancer pursuing concurrent chemotherapy and radiation therapy. exclusion criteria: * greater than stage iva cervical cancer * metastatic or recurrent cervical cancer * patients receiving only chemotherapy or only radiation therapy * history of cancer of any site * history of a transplant * diagnosed with any immunosupressive disorder (hiv, aids).

Keywords: cervical cancer healing touch healing touch therapy
a study to evaluate the efficacy and safety of cp-101,606 in subjects with an acute stroke

Conditions: Stroke

Summary: the purpose of this study is to determine whether a new research medication is effective and safe for the treatment of acute stroke when given within 6 hours of the onset of stroke.


Eligibility criteria:
inclusion criteria: males \& females age 40-90 years enrolled in study within 6 hours of onset of stroke symptoms willing to sign informed consent form no significant disabilities prior to stroke exclusion criteria: treatment with t-pa (tissue plasminogen activator) premorbid modified rankin scale score of 2 or more
expanded access to provide bay2927088 for the treatment of locally advanced or metastatic nsclc with her2 mutation

Conditions: Advanced Non-small Cell Lung Cancer; Cancer

Summary: the purpose of this expanded access program (eap) is to allow patients with locally advanced or metastatic non-small cell lung cancer (nsclc) with mutations in the human epidermal growth factor receptor 2 (her2) gene, which have no other therapeutic option, to receive bay2927088.


Eligibility criteria:
effectiveness of a prequirurgic instrument to decrease anxiety in urogical quirurgic patients: a randomized clinical trial

Conditions: Anxiety; Nurse-Patient Relations; Behavior

Summary: the overall aim of this program of research is to decrease anxiety in urogical scheduled patients for surgical intervention developing an nursing comunication instrument: a guide of hosting for urogical scheduled patients for surgical intervention.

the overall aim of this program of research is to decrease anxiety in urogical scheduled patients for surgical intervention developing an nursing communication instrument: a guide of hosting for urological scheduled patients for surgical intervention. the purpose of the proposed project is to establish the feasibility and acceptability of this guide to decrease the anxiety in this patients, using a randomized clinical trial like a research design, which would test the effectiveness of this communication instrument in comparation to a control condition (patients without guide of housting). to achieve the investigators specific aims, the investigator conducted a randomized clinical trial (n=50), with two groups: intervention group (with guide of hosting) and control group (which shows a control condition). valuation instruments were two validated scales: esas y hads. anxiety was the primary outcome variable assessed in the rct; depression and pain were a secondary outcomes variables.

Eligibility criteria:
inclusion criteria: * age limits: 18 years old. * with hospital admission scheduled at 5ªa hospitalization service of the university hospital of guadalajara for surgical intervention with urological diagnosis exclusion criteria: * patients with cognitive deficit. * patients with recurrent insomnia problems * without spanish language proficiency * patients that have participated in a clinical trial in the last three months.

Keywords: anxiety urogical guide of hosting comunication instrument patients
patients with tuberculosis, mycobacteriosis or latent tuberculosis

Conditions: Mycobacterial Infection; Tuberculosis (TB)

Summary: in the last 30 years, tuberculosis (tb) has re-emerged in industrialised countries as a public health, with a decrease in incidence among the resident population and an increase in the burden of immigrants. therefore, it becomes a priority to implement an effective tb control that relies on both rapid and reliable identification of active infections, with a adequate treatment and surveillance of resistance, but also on the identification of latent tuberculosis infections (itbl) in populations at higher risk of progression to the active disease, representing a source of infection for the community.

the study is non-pharmacological and monocentric. data from patients with clinical/radiological suspicion of mycobacteriosis or tuberculosis will be considered for which they have been received at the ou of microbiology of the polyclinic s.orsola-malpighi biological samples for mycobacteria research and/or blood samples for immunological investigations for latent tubercular infection in the period january 2012-may 2021 (retrospective part of the study); data from patients suspected of mycobacteriosis, tb or itbl from june 2021 to december 2026 (prospective part of the study, duration: 6 years, possibly renewable) will also be considered. the objectives of the study are: 1) analysis of epidemiological, demographic and clinical aspects of patients with tb, mycobacteriosis non-tubercular or itbl in the period january 2012-december 2026. 2) assessment of diagnostic accuracy of the most frequently used methods for microbiological diagnosis of tuberculosis (tb) or non-tubercular mycobacteriosis and immunological methods for the diagnosis of latent tubercular infection (itbl). 3) analysis of the microbiological characteristics (phenotypic and molecular) of mtb and ntm strains. 4) evaluation of the clinical outcome of patients with itbl/tb/ntm in treatment and follow-up in the post-treatment period.

Eligibility criteria:
inclusion criteria: * age of 18 years or more, * clinical/radiological suspicion of tb or non-tubercular mycobacteriosis or itbl for which sent to the microbiology laboratory at least one biological sample for the mycobacteria and/or a blood sample for the igra test; * obtaining informed consent. exclusion criteria: * none

Keywords: infection mycobacterial tuberculosis diagnosis latent tuberculosis infection mycobacterial non-tubercular microbiological tests
vitamin/mineral supplement for children with autism

Conditions: Autism Spectrum Disorder

Summary: this is an open-label 3 month clinical trial of a vitamin/mineral supplement designed for children with autism.

this is an open-label 3 month clinical trial of a vitamin/mineral supplement designed for children with autism. there will be pre/post assessments of autism symptoms,gi symptoms, and laboratory tests. typically-developing children will be assessed at baseline only (no treatments) for comparison.

Eligibility criteria:
inclusion criteria: 1. child age 3-17 years (up until 18th birthday) 2. previous diagnosis of asd by a psychiatrist, psychologist, or developmental pediatrician 3. verification of diagnosis by asu staff using the autism diagnostic interview-revised. 4. no changes in any medical, nutritional, dietary, behavior, or other treatment in the last three months, and a willingness to avoid any changes during the study 5. participant is able to wear a mask during the short visit for the blood draw. exclusion criteria: 1. parent/guardian is unable to read or speak english fluently. 2. use of a vitamin/mineral supplement in the past 3 months 3. previous adverse reaction to a vitamin/mineral supplement 4. unstable, poor health; seizure disorder that is not responsive to treatment or not on stable management or complex type; or other health conditions that would significantly increase their risk of adverse effects (per physician clinical judgement) 5. use of any medication which has a contra-indication for one of the ingredients in the vitamin/mineral supplement 6. a major single-gene disorder such as fragile x, down's syndrome. 7. major brain malformation 8. tube feeding 9. current participation in other clinical trials 10. females who are pregnant or who are sexually active without effective birth control. 11. clinically significant abnormalities at baseline on two blood safety tests: comprehensive metabolic panel and complete blood count with differential. 12. psychotropic medication use which can affect neurotransmitter levels/function - current or within past 2 months
predictors of non-access to therapeutic education programs among patients with type 2 diabetes, and/or asthma, and/or chronic heart failure in an emergency setting

Conditions: Therapeutic Education Program; Emergencies; Diabetes; Asthma; Heart Failure

Summary: chronic diseases are frequent and potentially severe. type ii diabetes, asthma and heart failure affect 3.3 million, 4 million and 1 million people respectively in france. they are sources of avoidable mortality as well as disabilities leading to a loss of years of full health life (dalys). cumulatively, they were responsible for the loss of more than 1 million dalys in 2019 in france. national and international recommendations also include tve in the management of these three diseases. this severity can be reduced by better management underpinned by therapeutic education. by improving their knowledge of the disease, it allows a better adherence of patients to the care project, the achievement of clinical and biological objectives, a decrease in the number of emergency room visits and unscheduled hospitalizations, and an improvement in the quality of life during the course of three frequent chronic diseases such as type 2 diabetes, asthma and heart failure. however, participation in a therapeutic education program remains highly variable depending on many parameters. lack of information seems to play a major role in this context. in the ile de france region, the density of available tep programs is high, particularly in paris. the three chronic diseases that are managed by an advanced practice nurse with a pcs mention have the largest number of tve programs in paris: type 2 diabetes (32, and 6 for diabetic foot), asthma and heart failure. in an urban area with a good supply of tve facilities, how can investigators explain the lack of integration of these facilities into the care pathway? among the diverse patient population consulting an emergency department suffering from type ii diabetes, asthma or heart failure, investigators wish to determine the proportion of patients who have not been offered tve during their care. investigators will then try to identify demographic, socioeconomic, and medical factors statistically associated with the absence of fte proposal.


Eligibility criteria:
inclusion criteria: * patient whose age is ≥ 18 years * patient consulting the ghpsj emergency department for any reason * patient with a chronic disease among type 2 diabetes and/or asthma and/or heart failure * francophone patient exclusion criteria: * diagnosis of the chronic disease in the context of its current management in the emergency room * patient being followed outside of ile de france for the chronic disease studied * patient with dementia or cognitive disorders * patient under guardianship or curatorship * patient deprived of liberty * patient under legal protection * patient opposing the use of his data for this research
a study to investigate the receptor occupancy of sk-1405 in healthy, caucasian, male subjects

Conditions: Pruritus

Summary: the primary objective is to confirm the target receptor occupancy of sk-1405 and to correlate receptor occupancy with sk-1405 dose and plasma concentration. the secondary objective is to assess the safety and tolerability of sk-1405 in healthy, caucasian, male subjects.


Eligibility criteria:
inclusion criteria: * able and willing to provide written informed consent to participate in this study, as confirmed by signing the informed consent document(s). * adult caucasian male aged ≥20 and ≤50 years. * body mass index (bmi) of ≥ 20 and ≤ 30 kg/m2. * height ≤ 190 cm. * subject is a non-smoker or has not smoked in the past 6 months. * subject is considered to be in good health in the opinion of the investigator. * subject's pre-study clinical laboratory findings are within normal range. * subject must be willing and able to comply with all protocol requirements. exclusion criteria: * use of prohibited medications as described in the study protocol. * current known or suspected history of drug/solvent abuse. * current known or suspected history of alcohol abuse or currently drinks in excess of 21 units per week. * subjects who have consumed caffeine containing products within 24 hours prior to baseline pet-ct. * any concurrent medical, surgical, or psychiatric condition that may affect the subject's ability to meet all protocol requirements during the study duration and/or any significant illness in the investigator's opinion in the 4 weeks before screening. * participation in any other clinical study with an investigational drug/device within three months prior to the first day of dosing and after enrolment in the current study. * subject has a positive result of hiv screen, hepatitis b screen or hepatitis c screen. * subject has had a serious adverse reaction or significant hypersensitivity to any drug. * subject has donated 500 ml or more of blood within the three months prior to screening. * history of neurological conditions. * participation in a research study or other radiation exposure which in conjunction with this study would result in additional ionisation radiation exposure exceeding 10 msv within the last year. * a contraindication for mri, including but not limited to, mri-incompatible pacemakers, recent metallic implants, foreign body in the eye, or other indications as assessed by a standard pre-mri questionnaire, that preclude the subject undergoing mri scans. * subject has claustrophobia. * subjects who have consumed saint john's wort, red wine, seville oranges, grapefruit or grapefruit juice within 7 days prior to dosing. * subject has a partner who is either pregnant or breastfeeding for the duration of the study.
exploratory study of relationships between malodor and urine metabolomics

Conditions: Nutritional and Metabolic Diseases

Summary: the purpose of this study is to identify metabolic signatures associated with malodor conditions. the investigators will perform state-of-the art metabolomics tests and bioinformatic data mining to explore if conditions leading to malodor can be screened by metabolomic profiling of urine samples.

in this study, metabolite profiling analysis will be carried out on urine samples of individuals with malodor conditions related to metabolism inefficiencies. metabolic profiles will be identified using the metabolomics equipment located in the nmr, hplc and ms facilities of the metabolomics innovation centre (tmic). multivariate statistical analyses will be used, as well as other approaches to mine complex data from heterogeneous sources.

Eligibility criteria:
inclusion criteria: * 18 years or older * unpredictable and uncontrollable episodes of malodor * willing and able to ship a urine sample (in the kit provided) by an overnight courier to edmonton, alberta, canada * good general health exclusion criteria: * serious medical conditions that require treatment * conditions that, in the opinion of the investigator, would prevent participation * under the age of 18 * elect not to participate in the study

Keywords: body odor, malodor, halitosis
french wilson disease registry

Conditions: Wilson Disease

Summary: this registry concerns adults and children with wilson's disease. the collection of a large amount of data will allow a better understanding of the epidemiology of this rare disease, in particular the age of onset according to the hepatic or hepato-neurological forms, but also the geographical distribution of patients consulting in france. this database will also make it possible to know all the therapies prescribed to "wilsonian" patients. the genetic study of these patients will make it possible to specify the various genetic mutations involved in wilson's disease. the information (clinical, biological, radiological and genetic) relating to the disease will be entered by a doctor or a professional specialising in wilson's disease.


Eligibility criteria:
inclusion criteria: * all patients suffering from wilson disease exclusion criteria: * lack of written consent from the patient or their legal representative
prehospital transcranial duplex in patients with acute stroke

Conditions: Stroke

Summary: the aim of the study is to investigate patients with acute stroke prehospital with transcranial duplex ultrasound to detect an infarct of the middle cerebral artery.

the investigation of the patients will be done by an anaesthesiologist who is part of the prehospital medical treatment in germany. the main question is, wether a non neurologist can detect an infarction of the middle cerebral artery in a short time an lead the patient to the indicated clinic.

Eligibility criteria:
inclusion criteria: * clinical signs of acute stroke * possibility of tcd exclusion criteria: * acute interventions for vital signs required

Keywords: stroke prehospital ultrasound