Kornimate/medical-research-clean huggingface dataset:
artificial intelligence aid systems and endocuff in colorectal adenoma detection

Conditions: Adenoma Detection Rate

Summary: the main purpose of the study to evaluate the usefulness of the endo-aid artificial intelligence system combined with endocuff compared with endocuff in the detection of colorectal adenomas in consecutive patients for outpatient colonoscopy. the secondary aims were: * to evaluate the benefit of endo-aid and endocuff in adenoma detection rate by comparing endoscopists with high and low adenoma detection rate. * to evaluate serrated detection rate, advanced adenoma detection rate, adenoma detection rate according to the size (\ = 10mm) and number of adenomas by colonoscopy. stratification by location and morphology.

guidelines have been established regarding artificial intelligence (ai) applied to gastrointestinal endoscopy. regarding the priority uses for their development, there are applications that improve vision, placing computer-assisted lesion detection (cade) as one of the most necessary priorities, given the importance of colorectal cancer screening (crc) and post-polypectomy surveillance. the evaluation of these systems in different clinical practices and patient groups has been recommend. in this regard, studies in the western population are limited and have been carried out by expert endoscopists. it has not been evaluated comparing with other strategies such as add-on devices. in addition, there are no studies with the recent cade endo-aid system (olympus corp. tokyo). the main purpose of the study is to evaluate the usefulness of the endo-aid artificial intelligence system with endocuff in the detection of colorectal adenomas in consecutive patients for outpatient colonoscopy compared with standard colonoscopy with endocuff. in addition, the benefit of the cade system will be assessed according to the endoscopist adr. a randomized controlled trial will be carried out in consecutive outpatients meeting the inclusion criteria and none of the exclusion criteria. patients with be randomized to one of the two groups: cade system with endocuff and standard colonoscopy with endocuff.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * patients referred for outpatient colonoscopy exclusion criteria: * colonic resection * taking anticoagulants or antiaggregants that contraindicate the performance of therapy * patients with a recent colonoscopy (\<6 months) of good quality (e.g. cited for endoscopic therapy) * ibd * patients with incomplete colonoscopy * patients with inadequate preparation using the boston colonic preparation scale (bbps). a cleaning quality of less than 2 points in any of the 3 colonic sections will be considered inadequate. * patients with polyposis syndromes
veraflo with prontosan® and wound and fracture healing.

Conditions: Infection

Summary: to answer the question: "do prontosan instillations decrease time to wound and fracture healing and decrease bacterial load compared to wound vac treatment without prontosan?," we will enroll up to 30 subjects (for an anticipated 20 complete data sets) into this trial. the subjects will be split equally into two different groups by randomization. one groups will have wound vac therapy with prontosan, and one group will have wound vac therapy without prontosan. data related to wound and fracture healing and bacterial load will be assessed between the two groups to determine if wound vac therapy with prontosan speeds up healing time and decreases bacterial load.

surgical site infections (ssis) are a devastating and relatively common surgical complication, occurring in 2% to 5% of patients undergoing surgery in the united states. ssis can significantly increase patient morbidity, hospital stay duration, healthcare costs, and patient mortality (anderson 2011). negative pressure wound therapy (npwt) with vacuum-assisted closure (vac) is an established adjunctive treatment option for open wounds that offers the ability to promote healing. however, there is limited evidence for its utility with active infections. wounds that are acutely infected or that contain an adherent biofilm present a challenging problem (kim et al 2015). wound vac therapy involves cleaning the wound, applying a custom-fit foam to cover the wound, placing a transparent drape over the wound and adjacent skin, and attaching tubing to connect the foam to a vac suction canister. npwt is achieved with a pulling force supplied by the vac suction canister. typically, suction will remain at a constant pressure until the dressing is removed. continuous vac therapy was recently reported to be more effective than standard moist wound care in surgical site infection after ankle surgery (zhou et al. 2015). vac therapy with instillations is a novel treatment option that provides the combination of negative pressure with intermittent instillation of a solution. polihexanide (prontosan®) is a modern antiseptic that combines a broad antimicrobial spectrum with low toxicity, high tissue compatibility, no reported adsorption and good applicability as solution, gel, ointment, foam and in wound dressing. unlike other antiseptics, the antimicrobial efficacy of prontosan® is not impaired in human wound fluid, human tissue or by high loads of blood or albumin. furthermore, prontosan® blocks the microbial attachment to surfaces and has been shown to effectively remove biofilms in vitro and in vivo (hubner et al 2010).

Eligibility criteria:
inclusion criteria: * patients 18 years and older * patients who will be undergoing surgical management (including the use of npwt therapy) of an infected lower extremity status-post open reduction and internal fixation (orif) exclusion criteria: * pregnant females * incarcerated patients and those not able to give informed consent

Keywords: lower extremity status-post orif
pediatric neck rescue access comparison

Conditions: Tracheostomy Complication; Anesthesia

Summary: two recent studies explored the emergency tracheotomy technique and the scalpel-bougie-tracheostomy technique as a neck rescue access for newborns and infants on a rabbit cadaver. both studies lacked a key feature of real surgical access - bleeding during a true emergency. the study's objective was to comparatively assess the two techniques in a simulated environment with simulated bleeding and decreasing vital signs from the monitor like in real emergencies.

with ethical committee's approval the investigarors recruited for this cross-over trial pediatric anesthesiologists and intensivists. emergency tracheotomy consists of four steps: vertical skin incision, strap muscles separation (2 backhaus clamps), anterior luxation of the trachea with a 3rd clamp, and vertical puncture with tip-scissors of no more than 2 tracheal rings to insert the tube. the scalpel-bougie-tracheostomy involves separation of neck tissues to expose the trachea and tracheal incision both with a scalpel to insert the bougie to facilitate tracheal intubation. participants were randomized to start either with emergency tracheotomy or scalpel-bougie-tracheostomy. they watched an instructional video and had four practicing attempts, followed by a fifth attempt which was assessed. afterward, they crossed over to the other technique.

Eligibility criteria:
inclusion criteria: * board certified pediatric anesthesiologists or pediatric intensive care doctor * informed consent signed exclusion criteria: * none

Keywords: pediatric airway tracheotomy efona cico
effect of octreotide on the colonic motility in pediatric patients

Conditions: Colonic Motility Index; Constipation

Summary: the research study is designed to test how a medication called octreotide affects the motility (contraction or squeezing) of the colon (large intestine). investigators are investigating whether octreotide can increase contraction and movement in the colon.

as mentioned above.

Eligibility criteria:
inclusion criteria: * male or female and undergoing colonic manometry for a routinely accepted indication including: evaluation of chronic constipation, unexplained abdominal distension (should have had previous diagnostic work up), recurrent fecal impaction, post hirschsprung's disease repair, chronic intestinal pseudo-obstruction, or suspected colonic dysmotility of any other cause. * children aged 12 months or older who are undergoing colonic motility under the supervision of dr. joseph croffie at riley hospital. * in the investigator's judgment, parent(s)/guardian(s) is mentally competent to provide informed consent to participate in the study. exclusion criteria: * • subjects with known or suspected allergy to octreotide. * subjects with known prolonged corrected qt interval (qtc) syndrome or highest risk qtc-prolonging agents (including mifepristone). * subjects with known history of ventricular arrhythmia. * subjects with history of any organ transplant who are taking cyclosporine at the time of the motility study. * subjects with history of small bowel transplant. * subjects less than 12 months old. * subjects with severe renal impairment * subjects with severe hepatic impairment * subjects taking bromocriptine, insulin, oral hypoglycemic agents, beta blockers, calcium channel blockers, quinidine, terfenadine, pimozide, sildenafil, tadalafil, and any agents to control fluid and electrolyte imbalance
long-term follow-up gene therapy study for achromatopsia cngb3 and cnga3

Conditions: Achromatopsia

Summary: this is a longer-term follow-up study of patients with achromatopsia associated with defects in cnga3 who participated in a clinical trial in which they received aav-cnga3 retinal gene therapy, or of patients with achromatopsia associated with defects in cngb3 who participated in a clinical trial in which they received aav-cngb3 retinal gene therapy.

the follow-up study is designed to collect data on the longer-term safety and efficacy of aav-cnga3 retinal gene therapy and aav-cngb3 retinal gene therapy.

Eligibility criteria:
inclusion in the study will be limited to individuals who: 1. are able to give informed consent or assent, with or without the guidance of their parent(s)/guardian(s), where appropriate 2. received aav2/8-hcarp.hcngb3 or aav2/8-hg1.7p.cocnga3 by intraocular administration in the prior open-label, phase i/ii, dose escalation study (eudract 2016-002290-35 or eudract 2018-003431-29) 3. are willing to adhere to the protocol and long-term follow-up individuals will be excluded who: are unwilling or unable to meet the requirements of the study

Keywords: achromatopsia cnga3 cngb3
characteristics of renal blood flow in aki patients in icu and its clinical significance

Conditions: Acute Kidney Injury; Renal Artery Blood Flow; Renal Venous Return; Renal Microcirculation

Summary: to study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical and medullary microcirculatory blood flow and renal function; and to find the value of ultrasonographic assessment of renal blood flow indices for evaluating prognosis in patients with sepsis.


Eligibility criteria:
inclusion criteria: * age between 18-85 years old; control group: patients with non-acute kidney injury after icu general surgery; observation group: patients who met the diagnostic criteria of aki: scr elevation ≥26.5 umol/l within 48h; scr elevation exceeding 1.5 times and more than the basal value within 7d; and decrease in urine output (\<0.5 ml/kg/h) with a duration of 6h or more. exclusion criteria: * those who did not meet the inclusion criteria or refused to be enrolled; patients with underlying end-stage renal disease or requiring long-term dialysis; renal transplant patients; patients with other underlying systemic diseases causing renal dysfunction (scr \> 88.4 umol/l); those who were unable to obtain a clear renal ultrasound view; those with suspected contrast allergy; those with pulmonary arterial systolic blood pressure ≥ 90 mm hg; and those who were pregnant or breastfeeding women.
aggressive driving and road rage: a driving simulation experiment.

Conditions: Aggression

Summary: driving a car is the most dangerous behavior most people engage in every day. according to the world health organization, about 1.25 million people die each year as a result of road traffic crashes, and they are the leading cause of death among 15 to 29 year olds. according to the national highway traffic safety administration, 37,461 americans were killed in motor vehicle crashes in 2016 - about 103 per day. although there are several causes of traffic crashes (e.g., texting, alcohol consumption, inclement weather), the leading cause is aggressive driving. in the united states, aggressive driving accounts for more than half of all traffic fatalities. thus, aggressive driving is an important applied health topic, especially for young drivers.

experimental studies are needed to draw inferences about the causes of aggressive driving. only six driving simulation experiments have been conducted, and one of these experiment was conducted by the investigators (bushman, kerwin, whitlock, \& weisenberger, 2017). the proposed research will test the effects of seven situational risk factors: (1) racing video games (experiment 2), (2) racial bumper stickers (i.e., "black lives matter" bumper stickers for white motorists vs. "all lives matter" bumper stickers for black motorists; experiment 3), (3) political bumper stickers (i.e., "donald trump for president 2016" for democrat motorists vs. "hillary clinton for president 2016" for republican motorists; experiment 4), (4) alcohol-related cues (i.e., a case of beer vs. water on the passenger seat; experiment 5), (5) music with violent lyrics (experiment 6), (6) music with an upbeat tempo (experiment 6), and (7) roadside trash (experiment 7). the proposed research will also test the effects of five situational protective factors: (1) racial bumper stickers (i.e., "black lives matter" for black motorists vs. "all lives matter" for white motorists; experiment 3), (2) political bumper stickers (i.e., "donald trump for president 2016" for republican motorists vs. "hillary clinton for president 2016" for democrat motorists; experiment 4), (3) music with prosocial lyrics (experiment 6), (4) music with a calm tempo (experiment 6), and (5) roadside vegetation (experiment 7).

Eligibility criteria:
inclusion criteria: * participants will be adults recruited from central ohio (franklin county) through advertisements (e.g., newspaper, internet). * participants' ages will vary depending on the experiment. 18 and older for experiment 1; 18-21 for experiments 2-4 and 6-7; 21+ for experiment 5 * all participants must have a current driver license. exclusion criteria: • participants who have motion sickness will be excluded.

Keywords: aggressive driving; road rage
phase 2 study with snf472 in calciphylaxis patients

Conditions: Calciphylaxis; Calcific Uremic Arteriolopathy

Summary: to evaluate the effect of snf472 on top of standard of care on promoting wound healing and other parameters of therapeutic response in haemodialysis patients with calciphylaxis (calcific uraemic arteriolopathy, cua).


Eligibility criteria:
inclusion criteria: 1. patients with either newly diagnosed cua or recurrent cua that has been dormant with no skin lesion involvement for at least 90 days from study start (new or recurrent diagnosis must be made within 5 weeks of study start) 2. patients who signed the written informed consent to participate in this clinical trial (prior to any clinical trial-related procedures being performed), after reading the patient information sheet and informed consent form (icf), and who had the opportunity to discuss the clinical trial with the investigator or designee 3. males or females aged ≥18 4. patients on maintenance haemodialysis (hd) 5. patients with at least a minimum level of pain on visual analog scale (vas) scale or on pain-killers stronger than non-steroidal anti-inflammatory drugs (nsaids) 6. females of child-bearing potential should use a highly effective contraceptive measure throughout the study and have a negative serum pregnancy test at entry. male patients having sexual relationship in which pregnancy can occur should take adequate contraceptive precautions (wear a condom) exclusion criteria: 1. body weight above 150 kg 2. bmi \>35 and central(abdominal) ulcers 3. history of bisphosphonate treatment within 12 months before entering into the study 4. severely ill patients without reasonable expectation of survival for \> 6 months according to the treating physician 5. patients with scheduled parathyroidectomy during the run-in or study period 6. female patients who are either intending to get pregnant or are undergoing treatment to get pregnant, as well as breast-feeding females 7. participation in another clinical trial with an experimental drug within 90 days prior the inclusion 8. any psychological, emotional problems, any disorders or resultant therapy that is likely to invalidate informed consent, or limit the ability of the patient to comply with the clinical trial protocol requirements 9. patients who, in the opinion of the investigator, are considered unsuitable for any other reason

Keywords: calciphylaxis calcific uremic arteriolopathy dialysis end stage renal disease rare disease (orpha280062) calcification calcium metabolism disorders calcinosis metabolic diseases
investigating the development, validity, and reliability of the avoidance of sports activities photo scale

Conditions: Questionnaire; Athletes; Shoulder Pain

Summary: "investigating the development, validity, and reliability of the avoidance of sports activities photo scale" is crucial in determining the specific functional status of the shoulder joint, especially for overhead athletes experiencing shoulder pain, to identify which sporting activities restrict them the most and to fill the gap in the literature. additionally, visually indicating activities through photographs will provide visual feedback, making it easier to assess functional status. our study aims to develop a specific functional survey for the shoulder joint in overhead athletes, examine the validity and reliability of this scale, and contribute to the literature.

developing a valid and reliable visual assessment scale specifically targeting shoulder pain in overhead athletes with shoulder pain, aiming to evaluate shoulder pain in a specific and functional manner, and investigating its psychometric properties.the research will be conducted at hacettepe university faculty of physical therapy and rehabilitation, athlete health unit. the research will be conducted according to the consensus-based standards for the selection of health measurement instruments (cosmin) guidelines. cosmin guidelines recommend a minimum of 100 participants for reliability, measurement error, and validity assessments. therefore, the study plans to include at least 100 individuals who apply to the athlete health unit at hacettepe university faculty of physical therapy and rehabilitation. the data collection for this planned study will be solely through surveys. the design of the study is a cross-sectional study aimed at developing and assessing the validity and reliability of the "avoidance of sports activities photo scale." surveys specific to the research will be implemented in the study.

Eligibility criteria:
inclusion criteria: * male and female athletes aged between 18-35, * engaged professionally in sports involving overhead activities for at least 3 years (volleyball, basketball, swimming, badminton, water polo, tennis, american football, handball, etc.), * actively participating in competitions for at least 1 year, * experiencing current traumatic or non-traumatic pain, or having a history of shoulder pain, or having chronic shoulder pain, * native turkish speakers. exclusion criteria: * neurological and/or rheumatological disease, * active local or systemic infection, * history of cancer, * severe visual impairment.
a two centre study to assess the stability and long-term performance of the c-stem™ amt in a total primary hip replacement

Conditions: Rheumatoid Arthritis; Osteoarthritis; Post-traumatic Arthritis; Collagen Disorders; Avascular Necrosis; Traumatic Femoral Fractures; Nonunion of Femoral Fractures; Congenital Hip Dysplasia; Slipped Capital Femoral Epiphysis

Summary: the purpose of this study is to monitor the stability of the c-stem™ amt hip within the thigh bone when used in the treatment of patients with hip joint disease requiring a total hip replacement. patients who enter the study will be evaluated at regular intervals following hip surgery using patient, clinical, standard x-ray assessments and special x-rays which allow the stability of the implant to be determined.


Eligibility criteria:
inclusion criteria: i) male or female subjects, aged between 60 and 80 years inclusive. ii) subjects who are able to give voluntary, written informed consent to participate in this investigation and from whom consent has been obtained. iii) subjects who, in the opinion of the investigator, are able to understand this investigation, co-operate with the investigational procedures and are willing to return to the hospital for all the required post-operative follow-ups. iv) subjects undergoing primary total hip replacement that are considered suitable for a cemented femoral stem and metal femoral head and an all polyethylene acetabular cup. exclusion criteria: i) subjects who, in the opinion of the investigator, have an existing condition that would compromise their participation and follow-up in this study. ii) subjects undergoing revision hip replacement iii) subjects undergoing simultaneous bilateral hip replacements. iv) subjects with a contralateral hip replacement, which was implanted less than six months previously or is not performing satisfactorily. v) women who are pregnant. vi) subjects who are known drug or alcohol abusers or with psychological disorders that could affect follow-up care or treatment outcomes. vii) subjects who have participated in a clinical study with an investigational product in the last 12 months. viii) subjects who are currently involved in any injury litigation claims.

Keywords: hip cemented
impact of "no-touch" technique on the outcome of liver transplantation for hepatocellular carcinoma

Conditions: Liver Transplantation; No-touch Technique; Hepatocellular Carcinoma

Summary: the "no-touch" technique has been one of the most important principles of oncological surgery and aimed to prevent seeding and tumor cell dissemination. previous studies in hepatectomy have shown that no-touch technique surgery can reduce hcc recurrence and improve the survival of patients. however, there is no consensus on whether the no-touch technique in lt for hcc improves the outcomes. this study aims to prospectively include liver transplant patients from multiple transplant centers, collecting their pre-transplant clinical information, post-transplant pathological records and exploring and clarify the correlation between "no-touch" technique and the prognosis of lt patients.


Eligibility criteria:
inclusion criteria: 1. diagnosis of hcc based on ct or mri imaging or needle biopsy confirming a histologic diagnosis of hcc. 2. patients undergoing deceased donor liver transplantation for the first time. exclusion criteria: (1) patients who received split lt or simultaneous transplantation, (2) patients who received re-transplantation, (3) patients with macroscopic portal vein tumor thrombosis or other macrovascular invasion, (4) patients with incomplete follow-up or incomplete important parameters records.