Kornimate/medical-research-clean huggingface dataset:
avatar-based therapy for female orgasmic disorder

Conditions: Female Orgasmic Disorder

Summary: a randomized controlled trial was conducted for testing the efficacy of a novel avatar-based intervention (ig), that was compared with a control group (cg) for women with female orgasmic disorder (fod). participants were 31 women who were randomly assigned to the intervention or the control conditions. intervention was based on the cognitive behavioral therapy approach (treatment with the most empirical evidence) and previous literature about fod. it consisted of 12 weekly online individual sessions and aimed at improving the fod diagnosis, sexual variables, and variables that are known to affect orgasm consecution. control group was based on minimum therapeutic contact. changes over time in the assessed variables were analyzed using linear mixed models, considering treatment group, measurement time point, and group-by-time interactions as fixed effects. effect sizes were computed (cohen's d; number needed to treat - nnt; reliable change index - rci).


Eligibility criteria:
inclusion criteria: * present the characteristics to diagnose female orgasm disorder after a clinic assessment (considering natural characteristics of the women's sexual response cycle (conn \& hodges, 2022) based on the dsm-5 criteria. * provide a medical check to prove the absence of physical factors that may be the cause of the orgasm dysfunction, as this is the first part to diagnose fod. * be at least 18 years old (adult). * have access to a computer with the characteristics to run second life and internet connection. exclusion criteria: * present a diagnosis of a physical condition that may be the cause of the orgasm dysfunction (e.g., genital lesions, systemic and hormonal factors, vulvovaginal atrophy). * presence of other psychological pathology (e.g., depression, trauma) that may be the cause of the orgasm dysfunction. * have alcohol dependence (i.e., evaluated during the clinical assessment, according to the diagnostic criteria from the dsm-5, to determine if the individual meets the criteria for an alcohol use disorder diagnosis). * drug use, including medication that is known to cause sexual difficulties (e.g., selective serotonin reuptake inhibitors (ssris), that are a particularly common drug cause of sexual dysfunction. * have participated in a previous psychological intervention in the last year.
feasibility study evaluating the parapatch system

Conditions: Urinary Incontinence

Summary: a multi-center, open-label, prospective, feasibility study evaluating the parapatch system for the treatment of urinary incontinence and overactive bladder.

* baseline period o the baseline period will allow for washout of any medication affecting bladder function and to allow subject to begin her voiding diary. * prospective data collection will take place in the form voiding diary. leak frequency, and other relevant parameters will be collected. * inclusion/exclusion criteria will be rechecked at end of baseline. * qol questionnaires will be completed in the office at the end of baseline period. * evaluation period o during the evaluation period, the subjects will use the parapatch system. * no medications affecting bladder function will be allowed during the evaluation period. * subjects will complete voiding diaries, during the evaluation period. data capture to include: adverse events, medication use, leak frequency and other relevant parameters. * qol questionnaires will be completed in the office at the end of evaluation period. * follow-up period o subjects will be followed for after the evaluation period to check for residual adverse events. * no medications affecting bladder function will be allowed during the follow-up period. * subjects will be called by the clinical coordinator at the end of the follow-up period and asked about potential adverse events.

Eligibility criteria:
inclusion criteria: * women aged from \>18 to \< 75 years old. * subject has the ability to read and comprehend english, and to reliably record information as required by the protocol, including the proper completion of the questionnaires. * subject is able to provide written informed consent prior to participation in the study. * diagnosed with either of the following: a) overactive bladder, or b) urinary stress incontinence. exclusion criteria: * are currently participating or have participated within the past 30 days in any clinical investigation involving or impacting urinary or renal function. * subject has demonstrated or is believed to be at risk of non-compliance with study procedures (e.g., for completing the diary or returning for required follow-up visits). * subject has undergone onabotulinumtoxin-a injections of the bladder in the last twelve (12) months. * subject is not suitable for the study for any reason (including overall health, pre-existing conditions or medications) in the judgment of the investigator. * have an untreated recurrent urinary tract infection (\> 2 times within the past 6 months). * have neurogenic disorders such as multiple sclerosis, als, or parkinson s disease. * patients with a diagnosis of painful bladder syndrome, other pelvic pain or interstitial cystitis.
using virtual technologies to prevent injuries in adolescents with acquired brain injury

Conditions: Acquired Brain Injury; Traumatic Brain Injury; Stroke

Summary: the objective of this study is to identify home safety hazards for adolescents with acquired brain injury and to identify adaptations to the home healthcare virtual simulation training system (hh-vsts) to improve the user experience for adolescents with abi

this study will determine the home safety hazards that place adolescents with abi at risk of injury. in addition, the study will determine ways to adapt our current home safety virtual simulation training system, a game based training and assessment that trains home healthcare workers to identify and respond to hazards they encounter in client homes. the study will include interviews with three stakeholders groups: adolescents with abi, parents of adolescents with abi, and healthcare providers working with adolescents with abi to identify home safety hazards encountered by adolescents with abi. we will demonstrate proof of concept for adolescents with abi through assessment of safety concerns from multiple perspectives and evaluation of design considerations from our intended user-group. further, we are applying the hh-vsts in a novel way to solve an understudied problem in adolescents with abi. in addition, we will apply a user-centered, participatory approach to assess the design consideration of virtual gaming technologies to health and safety training adolescents with abi.

Eligibility criteria:
inclusion criteria: 1. adolescent with an acquired brain injury between the ages of 12 - 17 (tbi diagnosis per medical record or self-report for those recruited via word of mouth or community) or 2. parent/caregiver (18+ years of age) of an adolescent with an acquired brain injury or 3. a health professional involved in discharge planning and community re-integration of adolescents with an acquired brain injury. 4. for online interview, must have access to a computer or smart tablet with reliable internet access, a microphone, a video camera, and speakers, headphones 5. speak and read english 6. able to answer interviewer questions
trial of iw-9179 in patients with diabetic gastroparesis (dgp)

Conditions: Diabetic Gastroparesis

Summary: the objectives of this study are to evaluate the safety of iw-9179 in patients with diabetic gastroparesis (dgp) and the effect of treatment on the cardinal symptoms of dgp.


Eligibility criteria:
inclusion criteria: * patient is a male or non-pregnant, non-breastfeeding female, and is age 18 years or older at the time of the screening visit. * patient has a confirmed diagnosis of type 1 or type 2 diabetes mellitus. * patient has a diagnosis of dgp with no history or evidence of mechanical obstruction, symptoms for at least 3 consecutive months preceding the screening visit, and delayed gastric emptying of solids documented within 2 years of the screening visit. * patient has a normal egd either during the screening period or within 2 years of the screening visit, with no evidence of structural or organic disease that may explain the patient's gastroduodenal symptoms. * patient is compliant with ediary completion. * patient agrees to refrain from making any new, major lifestyle changes. * patient is fluent and literate in english. exclusion criteria: * patient has a history or current symptoms of any organic or structural disease that, in the opinion of the investigator, can cause abdominal pain or discomfort and may confound the assessment of dgp symptoms. * patients with rumination syndrome, cyclic vomiting syndrome, anorexia nervosa, or bulimia. * patient is currently using a gastric electric stimulator or has had endoscopic pyloric injections of botulinum toxin within the 6 months prior to the screening visit. * patient has been hospitalized within the 2 months prior to the screening visit for uncontrolled diabetes mellitus, dgp, or associated malnutrition. * patient reports significant diarrhea during the four weeks prior to the screening visit, or more than 2 days during either week of the pretreatment period. * patient has had surgery of the gi tract any time before the screening visit, an appendectomy or cholecystectomy during the 3 months before the screening visit, non-gi surgery of the abdomen, pelvis, or retroperitoneal structures during the 6 months, or other major non-gi surgery during the 30 days before the screening visit. * patient has a history of cancer (resected basal cell or squamous cell carcinoma of the skin is acceptable).
true continuous ecg monitoring (tcem study)

Conditions: Cardiac Arrhythmia

Summary: the purpose of this study is to compare short term (up to 48 hours) traditional cardiac rhythm monitoring using a standard ambulatory holter monitor versus long term (up to 14 days), continuous ambulatory cardiac rhythm monitoring using a new device cleared by the fda (zio® patch), irhythm technologies, inc., san francisco ca) in patients with suspected cardiac arrhythmias.

this is a prospective, observational study of patients seen in the holter lab at scripps green hospital and other scripps clinic locations. only patients who have indications for traditional cardiac rhythm monitoring will be enrolled in the study. patients 18 years or older with suspected arrhythmias capable of providing informed consent will wear both a traditional holter monitor for up to 48 hours and a zio® patch for up to 14 days. both devices will be initiated at the same time as they do not interfere with one another. this will also allow a direct comparison of the same initial up to 24 hour monitoring period between the two devices. as the zio® patch is worn for up to 14 days instead of only 24 hours, it will be assessed if in the physician's opinion (referring physician), waiting for the extended time hinders being able to provide medical care and/or diagnosis for the patient.

Eligibility criteria:
inclusion criteria: * are being seen in the outpatient office for evaluation, treatment, or follow-up of arrhythmias; * have a medical history for which ascertaining whether asymptomatic arrhythmias is occurring could be helpful in their treatment plan; * are capable of giving informed consent; assessed by the investigator or the study coordinator; * are 18 years of age or older; * able to comply with long term continuous monitoring ecg device. exclusion criteria: * have known skin allergies, conditions, or sensitivities (e.g. allergy to adhesives, psoriasis) as the zio(r)patch should not be used on patients with known skin allergies, conditions, or sensitivities; or * are receiving pacing therapy (e.g., from a pacemaker); or * are anticipated to receive or require external cardiac defibrillation during the monitoring period; or * are anticipated to be exposed to high frequency surgical equipment during the monitoring period.

Keywords: cardiac arrhythmia monitoring holter monitoring continuous ecg monitoring event monitoring observational
does valproate increase levels of folate receptor autoantibodies in women?

Conditions: Epilepsy; Psychiatric or Mood Diseases or Conditions

Summary: women who take folate (folic acid) before getting pregnant can lower the risk of giving birth to infant with certain birth defects. however, some medications may affect the action of folate. the purpose of this study is to compare the effect of two anti-epileptic drugs on how folate works in our body.


Eligibility criteria:
inclusion criteria: * women ages 18-50 years inclusive who are taking valproate or lamotrigine for neurologic or psychiatric conditions * valproate of lamotrigine must be used as monotherapy at stable doses for 6 weeks prior to the study for the neurologic or psychiatric illness; medications taken for other reasons are not excluded. exclusion criteria: * women with prior exposure to valproate or lamotrigine if they are taking lamotrigine or valproate respectively.

Keywords: folate receptor autoantibodies epilepsy psychiatric conditions
total hip arthroplasty (tha): early load versus load late

Conditions: Primary Total Hip Arthroplasty

Summary: in brazil, several hip surgeries performed, especially total knee arthroplasty, which represents 1.5 million procedures (penedo, new, 2007). the rehabilitation of these individuals is slow with respect to the march because it requires an aid and not to use the operated leg as support for three weeks, according to conventional methods. after the third week, the support becomes part and after that period (sixth week), the support becomes total. therefore, and in order to provide better quality of life, the goal of this work is to compare the march in 40 patients divided into two groups of 20 subjects each. in the control group, the treatment approach is the traditional, i.e., without immediate loading, while the other charge will be applied immediately in the operated limb. in order to verify the possible gain in the quality of life of these patients, the sf-36 will be applied. the march will be assessed with the time up and go test and the force platform and the harris hip score analyze the function of the hip. individuals will receive such care at the institute of orthopedics and traumatology, hospital das clinicas, faculty of medicine, university of são paulo (iot - hc - usp). the results of comparisons between the two groups and the clinical findings obtained will be subjected to appropriate statistical tests, guided by the principles of evidence-based clinical practice, seeking to facilitate and improve the lives of these individuals so they can move freely.


Eligibility criteria:
inclusion criteria: * patients served by the institution with tha without cement; * bmi less than 40, ie, present in most class ii obesity; * patients with diseases such as osteoarthritis and osteonecrosis of the femoral head; * absence of systemic involvement; * patients with prosthetic type lépine. exclusion criteria: * bilateral arthroplasty; * partial arthroplasty; * arthroplasties for review; * cemented arthroplasties; * surgical complications.

Keywords: total hip arthroplasty tha prosthesis type lepine
prevalence and risk factors of reventilation syndrome in a population of patients under ventilation for whatever reason

Conditions: Prevalence of and Factors Associated With Reventilation Syndrome (DS)

Summary: non-invasive nocturnal ventilation is an effective treatment for chronic respiratory failure, whether due to obstructive (copd), restrictive or neuromuscular causes, notably for patients in the last two categories for whom it significantly prolongs life expectancy. overall, the treatment is well tolerated, its principal adverse effects being discomfort related to the mask. in certain patients, morning dyspnoea when the mask is removed has been described. this is disabling as it limits everyday activities for at least 30 minutes, and defines deventilation syndrome. the pathophysiology of this syndrome is uncertain, notably the roles of hyperinflation, patient/ventilator asynchrony, or the sudden increase in diaphragmatic work after a night of rest. the aim of this study is to investigate the prevalence of and factors associated with reventilation syndrome (ds) in a population of patients with ventilation whatever the reason, in a stable state, and followed by the medical devices department of dijon chu, so as to better understand the mechanisms. patients with ds will subsequently be invited to participate in a therapeutic trial.


Eligibility criteria:
inclusion criteria: * patients over 18 years old * ventilation for whatever reason * in the st mode * not in life support * at more than 1 month after the last episode of respiratory decompensation exclusion criteria: * guardianship * inability to understand instructions and provide consent * uncontrolled psychiatric disease
influence of cooling on the effect of strength training

Conditions: Strength Training Effects

Summary: the aim of this study is to investigate if regular cold water immersion after strength training has a negative influence on the desired training-induced performance enhancement.

recovery strategies represent a not sufficiently investigated chance in elite training control to optimize the complete training process. coaches and athletes are confronted with numerous potentially effective recovery methods, e.g. cooling, warming, active recovery, compression, massage or power naps. however, the effectivity of these methods has rarely been investigated under controlled scientific conditions. based on the state of the art,so far hardly any definite practical conclusions regarding effective recovery methods can be drawn, especially regarding sport-specific strategies and settings. currently, cold water immersion is a particularly popular recovery strategy. however, there are hints that repeated cooling interventions after training can impair the training effect. this could potentially be caused by a faster reconstitution of homeostasis due to cooling. for fast recovery of performance, this effect would be desirable, but at the same time these homeostatic disturbances are the basis of signal processes leading to training adaptations. the aim of this study is to investigate if regular cold water immersion after strength training has a negative influence on the desired training-induced performance enhancement.

Eligibility criteria:
inclusion criteria: * healthy, 18-40 years, strength training experience, 8 weeks no leg strength training exclusion criteria: -

Keywords: cold water immersion, strength training, training effect
prehospital severe traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: the aim of the study is to measure the effect of finnish physician-staffed ems unit treatment methods on traumatic brain injury (tbi) patient prognosis. in the second part of the study the gathered data will be combined with the data from an earlier study (nct01454648) for regression analysis. the aim of the second study is to identify prehospital factors influencing the prognosis of prehospital tbi patients.

a secondary aim is to identify out-of-hospital treatment factors that can be influenced by education and protocols.

Eligibility criteria:
inclusion criteria: * tbi with gcs ≤ 8 or unconsciousness verified by an on-call neurosurgeon during admission to the hospital exclusion criteria: * multiple trauma

Keywords: traumatic brain injury
effects of complementary feeding counseling on appropriate complementary feeding practices and child undernutrition

Conditions: Feeding Behavior

Summary: appropriate complementary feeding practices as per the world health organization recommendations is a window of opportunity to promote health and prevent acute and chronic undernutrition (stunting, wasting \& underweight). globally, the burden of undernutrition remains unacceptably high, and the progress of undernutrition reduction is unsatisfactorily slow. in ethiopia, appropriate complementary feeding practices of mothers to their children are very low. in contrast, child undernutrition is a major public health problem.

appropriate nutrition during the first 1000 days of life lays the foundation for a child's health and well-being. introduction of complementary foods within 6-8 months of age and step-wise increase of diversified plant and animal-based diets is necessary, for which exclusive breast milk is no longer enough to meet the nutritional needs. appropriate complementary feeding practices as per the world health organization recommendations is a window of opportunity to promote health and prevent acute and chronic undernutrition (stunting, wasting \& underweight). globally, the burden of undernutrition remains unacceptably high, and the progress of undernutrition reduction is unsatisfactorily slow. in ethiopia, appropriate complementary feeding practices of mothers to their children are very low. in contrast, child undernutrition is a major public health problem. this study aims to determine the effects of complementary feeding counseling on appropriate complementary feeding practices and child undernutrition through a community-based randomized controlled trial.

Eligibility criteria:
criteria: inclusion criteria: 1. mother-child pairs whose children are 6 months old. 2. mother-child pairs who reside in the study area for at least 6 months before the survey. 3. mother-child pairs who have no intention of leaving the study area during the intervention period. exclusion criteria: 1. mothers with severe mental illness or who are unable to communicate (e.g., deaf). 2. mother-child pairs with severe congenital malformations of their children.

Keywords: complementary feeding counseling (cfc) appropriate complementary feeding practices (acfp) child undernutrition
use of intrathecal analgesia in appendectomy

Conditions: Anesthesia; Analgesia

Summary: acute appendicitis which is the most common cause of acute abdominal pain, is an acute inflammation of appendix vermiformis. appendectomy operations can be performed as laparoscopic and open surgery. addition of opioids to intrathecal local anesthetics to improve the quality of preoperative analgesia is an increasingly used method in recent years. the aim of this study is to compare bupivacaine-fentanyl and bupivacaine-alfentanil which are used intrathecally to create motor and sensory block. 50 volunteer patients who were diagnosed as appendicitis by laboratory tests and clinical diagnostic methods in general surgery clinic and classified as american society of anesthesiologists classification i-ii (asa class i-ii) aged between 20-60 years scheduled for laparoscopic appendectomy operation, were included in this study. the patients were randomly assigned into two groups, group i and group ii. patients received spinal anesthesia with either 10 mg heavy bupivacaine (2 cc)+25 mcg fentanyl (0.5 cc) intrathecally (group i, n=25) or 10 mg heavy bupivacaine (2 cc)+250 mcg alfentanil (0.5 cc) intrathecally (group ii, n=25).


Eligibility criteria:
inclusion criteria: * individuals who will undergo laparoscopic appendectomy operation and volunteer to participate in the study were included. exclusion criteria: * individuals who meet the criteria but are not volunteers * previously underwent appendectomy

Keywords: intrathecally fentanyl alfentanil visual pain scale analgesia