Kornimate/medical-research-clean huggingface dataset:
psychiatric neurosurgery (pns) for obsessive compulsive disorder (ocd): a qualitative analysis of patient and family member experiences

Conditions: Obsessive-Compulsive Disorder

Summary: in this study the investigators will use semi-structured interviews to qualitatively analyse patient and family member experiences with either deep brain stimulation or other forms of psychiatric neurosurgery.


Eligibility criteria:
inclusion criteria: * (family member of) patient who has previously been treated with deep brain stimulation or anterior capsulotomy exclusion criteria: * none

Keywords: deep brain stimulation anterior capsulotomy
phase i dose escalation study of intravenously administered s64315 in combination with orally administered venetoclax in patients with acute myeloid leukaemia.

Conditions: Acute Myeloid Leukaemia

Summary: the purpose of this study is to determine the safety profile, tolerability and the recommended phase 2 dose of the combination s64315 with venetoclax in patients with acute myeloid leukaemia.


Eligibility criteria:
inclusion criteria: 1. male or female aged ≥ 18 years; 2. patients with cytologically confirmed and documented de novo, secondary or therapy-related aml as defined by world health organization (who) 2016 classification (arber, 2016), excluding acute promyelocytic leukaemia (apl, french-american british m3 classification): * with relapsed or refractory disease without established alternative therapy or * secondary to mds treated at least by hypomethylating agent and without established alternative therapy or * ≥ 65 years not previously treated for aml and who are not candidates for intensive chemotherapy nor candidates for established alternative therapy 3. eastern cooperative oncology group (ecog) performance status ≤ 2 4. able to comply with study procedures 5. adequate renal function within 7 days before the inclusion of the patient defined as: • serum creatinine ≤ 1.5 x uln (upper normal limit) or calculated creatinine clearance (determined by mdrd) \> 50 ml/min/1.73m2 6. adequate hepatic function within 7 days before the inclusion of the patient defined as: * ast and alt ≤ 1.5 x uln * total serum bilirubin level ≤ 1.5 x uln, except for patients with known gilbert's syndrome, who are excluded if total bilirubin \> 3.0 x uln or direct bilirubin \> 1.5 x uln exclusion criteria: 1. participant already enrolled and treated in the study 2. pregnancy, breastfeeding or possibility of becoming pregnant during the study 3. participation in another interventional study requiring investigational treatment intake at the same time or within 2 weeks or at least 5 halflives (whichever is longer) prior to first dose of imp (participation in non-interventional registries or epidemiological studies is allowed). in case of biologic agents with a long half life such as cart cells, immune checkpoint antibodies, bispecific antibodies a flat wash-out of 28 days will be acceptable 4. presence of ≥ ctcae grade 2 toxicity (except alopecia of any grade) due to prior cancer therapy, according to the national cancer institute common terminology criteria for adverse events (ncictcae, version 4.03). 5. known carriers of hiv antibodies 6. known history of significant liver disease 7. uncontrolled hepatitis b or c infection 8. known active acute or chronic pancreatitis 9. history of myocardial infarction (mi), unstable angina pectoris, coronary artery bypass graft (cabg) within 6 months prior to starting study treatment 10. any factors that could increase the risk of qtc prolongation or risk of arrhythmic events.
comparing number of injection sites of in-office intravesical onabotulinumtoxin a treatments for overactive bladder: a randomized controlled trial

Conditions: Overactive Bladder Syndrome; Overactive Bladder

Summary: overactive bladder (oab) is a syndrome characterized by urinary urgency, with or without urinary incontinence, nocturia, and urinary frequency. intravesical injection of onabotulinumtoxina is approved by the us food and drug administration for treatment of neurogenic and idiopathic oab. current standard of practice involves 100 u of onabotulinumtoxina diluted in 10 ml saline cystoscopically injected into approximately 20 different detrusor muscle sites equally distributed along the posterior bladder wall and dome. this treatment was classically done in the operating room under general anesthesia, but now is typically performed in an office setting using local anesthesia (lidocaine) as this is more feasible and tolerable. patients can experience discomfort and pain with each injection. evidence has also shown that administering the same dose of onabotulinumtoxina into fewer injection sites in the detrusor muscle (ranging from 3 to 10) results in equivalent efficacy compared to the current standard. however, it has yet to be determined if there is a significant difference in patient satisfaction and tolerability when the procedure is administered in an office setting using the same dosage with fewer injections. our study aims to assess whether patient tolerance and satisfaction of intravesicular onabotulinumtoxina increases with the use of 4 detrusor injections as opposed to 20 injections when performed in an office setting on women with oab.


Eligibility criteria:
inclusion criteria: * females, adults 18 years of age and older, diagnosed with oab exclusion criteria: * bladder pathology including nephrolithiasis, active urinary tract infection, bladder trauma, neurogenic bladder, patients who have previously received intravesical onabotulinumtoxin a injections, pregnant patients, minor patients, male patients
postoperative pain assessment after canal preparation by different niti file systems

Conditions: Post Operative Pain; Inflammation

Summary: the participants were divided into two groups : group one ( trunatomy file group)(n=10) was mechanically prepared the canals by trunatomy file and group two ( edgeendo x7 file group) ( n=10) was prepared the canals by edgeendo x7 file, the participants were assessed pain preoperatively and postoperatively by visual analog scale(vas)

patients : 20 patients with symptomatic apical periodontitis related to mandibular premolars were selected.after proper anathesia, access cavity was ppreformed.the working length measured using apex locator.chemomechanical preparation was done .for trunatomy file group ,using file sequence according to manufacture's instructions until medium one .for edgeendo group ,using file sequence also according to manufacture's instructions until file size 35 taper4.apical fluid samples was collected by paper point from the both preoperatively and before obturation and also pain was assessed pre and post opertively.finally,the root canal were filled by gutta-percha and resin based sealer.the access cavity was restored by glass ionomer restoration.

Eligibility criteria:
inclusion criteria: * clinical diagnoses of apical periodontitis related to single-rooted mandibular premolars * no evidence of excessive mobility exclusion criteria: * presence of any systemic disease or allergic reaction * incompletely formed root * previously endodontically treated teeth

Keywords: post operative pain substance p apical periodontitis trunatomy file edgeendo x7 file
safety and efficacy of cryoballoon ablation of atrial fibrillation as first-line therapy

Conditions: Paroxysmal Atrial Fibrillation

Summary: cryoballoon ablation of paroxysmal atrial fibrillation can be used as first-line therapy compared to second choice after failed medical therapy


Eligibility criteria:
inclusion criteria: * paroxysmal atrial fibrillation, symptomatic exclusion criteria: * atrial fibrillation other than paf, asymptomatic, previous af ablation
the treat-to-target study of ra based on smart system of disease management(ssdm)

Conditions: Rheumatoid Arthritis

Summary: this study evaluate the smart system of disease management（ssdm）to improve the treat-to-target(t2t) and the safety of drug in the treatment of rheumatoid(ra). all participants will be randomized in the ssdm group and the control group. the patients in the ssdm group will use the ssdm every month and the control group will receive the conventional therapy.

treat-to-target (t2t), achieving a das28 score lower than 2.6 (remission, rem) or below 3.2 (low disease activity, lda), is the main management strategy recommended by acr and eular. the smart system of disease management (ssdm) is an interactive mobile disease management tool, including the doctors' and patients' application system. the patients can perform self-evaluation, including das28, morning stiffness duration (msd) and haq, and input medical records (including medication and laboratory test results) through the mobile application. the data synchronizes to the mobiles of authorized rheumatologists through cloud data base and advices could be delivered.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of rheumatoid arthritis. 2. have a smartphone 3. must be able to access disease activity by themselves exclusion criteria: 1. not able to access disease activity by themselves 2. lacks the ability of self-management 3. mental disorders or severe physical dysfunction 4. extremely poor compliance

Keywords: treat-to-target smart system of disease management drug use
pharmacological treatment of comorbid alcohol and marijuana withdrawal and dependence

Conditions: Cannabis Dependence; Alcohol Dependence; Cannabis Use Disorder; Alcohol Use Disorder

Summary: the primary aim of the supplemental study is to provide poc testing of aprepitant as a treatment for comorbid alcohol and cannabis dependence. the data analysis plan specified in the parent grant will likewise be applied to the supplemental project to test for effects of aprepitant vs placebo on measures of alcohol and cannabis use and protracted withdrawal. the primary hypothesis is that subjects treated with aprepitant will have significantly less alcohol and marijuana use than subjects treated with placebo.

consistent with the scope and methods of the parent grant, this was a randomized, double-blind, placebo-controlled, parallel groups, phase ii, single-site, 8-week clinical trial of aprepitant 125 mg/d or placebo. participants were 20 outpatients seeking treatment for concurrent alcohol and cannabis dependence. all participants received weekly protocol-specific counseling. research assessments occurred weekly through the treatment phase of the 8-week study. post treatment follow-up assessments occurred at weeks 9 and 12.

Eligibility criteria:
inclusion criteria: * males or females from 18-70 years of age * meets dsm iv criteria for current alcohol and cannabis dependence * seeking research-based outpatient treatment for alcohol and cannabis dependence that involves daily oral medication * negative bac and a ciwa score \< 9 at randomization exclusion criteria: * significant medical disorders or use of medications that will increase potential risk or influence study outcomes * females who are pregnant, nursing or who are sexually active with child-bearing potential and refuse to use an effective, non hormonal method of birth control during the study and for up to 4 weeks after study termination• treatment with an investigational drug during the previous month * prior treatment with nk1 antagonists * participants for whom treatment is being mandated by a legal authority• inability to understand and/or comply with the provisions of the protocol and consent form

Keywords: cannabis treatment alcohol treatment alcohol-related disorders cannabis-related disorders substance-related disorders emend nk1 receptor antagonist alcohol cannabis aprepitant
effect of paracetamol,pregabalin and dexamethasone on pain and opioid requirements in postoperative patients

Conditions: Pain, Postoperative

Summary: women scheduled for abdominal hysterectomy needs postoperative pain treatment, i.e. morphine. unfortunately morphine has side-effect: nausea, vomiting, sedation and dizziness, which is unpleasant for the patients and sometimes keeps them at bed longer time than needed. we investigate in new combinations of analgesics for postoperative pain, hoping to minimize the need for morphine.

combinations of paracetamol versus paracetamol + pregabalin versus paracetamol + pregabalin + dexamethasone is investigated. primary outcome is 24 hours morphine usage.

Eligibility criteria:
inclusion criteria: * women scheduled for abdominal hysterectomy, between the age of 18 and 75, asa 1-2 * bmi between 18-32. exclusion criteria: patients who: * are unable to cooperate * has cancer ovarian * does not speak danish * has allergy for drugs used in the trial * has drug and medicine abuse * epilepsy * diabetes treated with medicine * chronic pain condition * daily use of antacids or analgesic * known kidney disease * use of antidepressive

Keywords: abdominal hysterectomy pregabalin dexamethasone multimodal postoperative analgesia
opioid system cerebral activity in endurance sportswomen - addiction or denutrition ? [11c]diprenorphine pet study

Conditions: Sports Nutritional Sciences

Summary: abnormal opioid system have been identified in addictive behavior and activity of the opioid system has also shown a strong link with the nutritional balance. a significant increase in endorphin levels was noticed after exercise, proportional to the duration and intensity of this activity. one brain imaging study showed an increase in opioid activity in athletes after endurance training. however , a decrease in opioid tone related to receptor desensitization in the brain has been raised in the sport and it is possible to feel like , the subject must perform physical exercise more frequently . consequently, in order to deepen the hypothesis of addiction in high-level sport , the brain opioid activity should be assessed pre- training compared to a group of sedentary control subjects . preliminary results of a previous study the investigators are conducting on anorexia nervosa (an ) show abnormalities that appear to be involved in self addiction anorexia nervosa and the regulation of gonadal function. however, the relation of cause and effect between these anomalies and undernutrition remains to be determined . given the addictive component in the endurance sport and the variability of the nutritional status of its practitioners , evaluation of brain activity in these subjects could provide additional answers.


Eligibility criteria:
inclusion criteria: for high-level sportswomen : * 18-35-year-old * high-level sportswomen * bmi\>19kg/m2 * absence of eating disorders * in pre-competition period * signature of written consent for controls : * 18-35-year-old * sedentary normal weight women * bmi\>19kg/m2 * normal nutritional markers * absence of eating disorders or other psychiatric or organic diseases exclusion criteria: * oral contraception * heart failure * neuroleptics, antiparkinson drugs, alpha-methyl-dopa, beta blockers, inhibitors of monoamine oxidase-a or moa-b, tricyclic antidepressants, selective serotonin reuptake inhibitor, thyme-regulators (lithium), anticonvulsant drugs, codeine, morphine, drugs containing tramadol, dopaminergic drugs

Keywords: endurance sportswomen addiction undernutrition [11c]diprenorphine pet pituitary region
d-cycloserine as an adjunct to internet-cbt for ocd

Conditions: Obsessive-compulsive Disorder

Summary: the purpose of this study is to examine if d-cycloserine is an effective adjunct to internet-based cognitive behaviour therapy for patients with obsessive-compulsive disorder.

trial objectives: primary aim is to investigate whether d-cycloserine gives incremental effects to icbt in terms of reduced ocd symptoms. secondary aims are to a) replicate previous findings in that dcs fastens the effects of cbt, b) correlate the fastened effect to overall treatment adherence and c) investigate gene variation and therapeutic factors as predictors of symptom severity, symptom type and treatment response. trial design: double blinded randomized controlled trial dose/duration: 5 capsules of 50 mg d-cycloserine or placebo. 1 pcs per week for 5 weeks. all participants also receive internet-based cognitive behavior therapy for 12 weeks. primary endpoint: change from w0-w13 and 3-months follow-up. efficacy parameters: y-bocs clinician rated. safety parameters: adverse events assessed weekly via the internet and also at post-treatment and at 3-months follow-up using face-to-face clinician assessments. description of trial subjects: fulfilling diagnostic criteria of ocd not associated with hoarding. number of subjects: 128

Eligibility criteria:
inclusion criteria: * outpatients * male or female * ≥ 18 years * currently living in stockholm, uppland, örebro, södermanland, gästrikland, västmanland and östergötland county in sweden. * primary diagnosis of ocd according to the dsm-iv-tr. * signed informed consent * have regular access to a computer with internet access and skills to use the web * have received information about the need of using contraception exclusion criteria: * pregnancy or breast feeding * patients unlikely to cooperate fully in the study * patients not able to read or understand the basics of the icbt self-help material * psychotropic medication changes within two months prior to treatment * completed cbt for ocd within last 12 months * y-bocs \[21\] \< 16 at psychiatrist visit (6.2.3)pi * ocd symptoms primarily associated with hoarding. * other primary axis i diagnosis according to the mini-international neuropsychiatric interview (mini) \[34\] * ongoing substance dependence * lifetime bipolar disorder or psychosis * suicidal ideation * axis ii diagnosis that could jeopardize treatment participation * serious physical illness that will be an obstacle in icbt and dcs * other ongoing psychological treatments that could affect ocd symptoms * epilepsia * renal impairment * hypersensitivity to d-cycloserine * porphyria * chronic alcoholism

Keywords: obsessive-compulsive disorder internet cognitive-behaviour therapy d-cycloserine
investigation of the effect of virtual reality environment on developing clinical skills in nursing students

Conditions: University Students

Summary: to reduce the negative consequences of these problems in clinical practice on the quality of education in the nursing profession, laboratory applications of vocational courses in undergraduate education have become more important. in this context, the research aimed to determine the use of a virtual reality application, an innovative training method to increase the quality of nurses' clinical practice training, in the obstetrics-gynecology and diseases nursing (dksh) course and its effect on students' course success. i

when considering the duties and responsibilities of nurses in the health system, it is necessary to train well-educated, professional nurses to ensure patient safety and quality of care. however, nurses' many problems with their clinical practice are important obstacles to getting a good education. to reduce the negative consequences of these problems in clinical practice on the quality of education in the nursing profession, laboratory applications of vocational courses in undergraduate education have become more important. in this context, the research aimed to determine the use of a virtual reality application, an innovative training method to increase the quality of nurses' clinical practice training, in the obstetrics-gynecology and diseases nursing (dksh) course and its effect on students' course success. in the study, the virtual reality application was prepared for preeclampsia, postpartum care and condom counseling, which are the most frequently encountered by students in professional practice and are of great medical importance. in addition, the effect of simulation training in the virtual reality environment on the student's decision-making self-confidence and anxiety in real clinical practice was also evaluated. in this context, the research aims to determine the effect of a virtual reality environment on improving clinical skills in nursing students.

Eligibility criteria:
inclusion criteria: * being 18 years of age or older, taking the obstetrics, gynecology and obstetrics nursing course for the first time, attending the course and taking the information technology course. exclusion criteria: * being visually or hearing impaired, graduating from a health vocational high school, arriving late or leaving early for case discussions or role-play scenarios, and staying in the virtual environment for less than 5 minutes.

Keywords: nursing virtual reality environment case discussion role playing the presence questionnaire nursing anxiety and self-confidence with clinical decision making scale
the effect of afos on the emg of children with cp

Conditions: Spastic Cerebral Palsy

Summary: children with cerebral palsy (cp) have altered gait patterns as a result of primary and secondary symptoms. ankle-foot orthoses (afos) are frequently used to improve their gait. despite evidence of afo-effects on gait kinetics and -kinematics, the effects on muscle activity remain unclear. this study will investigate the effect of afos on the amplitude and timing, as well as the co-activation of lower limb muscle activity in children with spastic cp.

with a prevalence of two to three per 1000 live births, cerebral palsy (cp) is the most common motor disability of childhood. improving disturbed gait in ambulatory children with cp is an important treatment goal because it is associated with functional independence and participation of children in the society. it is a common practice to prescribe ankle-foot orthoses (afo) for ambulatory children to improve their gait, prevent secondary deformities, provide an improved base of support, and compensate for muscle weakness. previous research highlighted that there is a direct effect on the muscle activity of the distal muscles and an indirect effect on the proximal muscles. however, the impact of the afo on the muscle activity of the plantar and dorsiflexors is clinically relevant since reduced muscle activity may lead to muscle atrophy and altered motor control. therefore, more research is needed on the effect of afos on the medial gastrocnemius and the tibialis anterior, in both unilaterally and bilaterally involved children. moreover, the impact of the afo on the muscle activity of the quadriceps, apart from the hamstrings, needs to be further explored as well. the purpose of the current study is to investigate the effect of the afo on muscle activity in the distal and proximal leg muscles of children with cp while walking. on the measurement day, subjects will first receive a standard clinical examination preceding the clinical overground three-dimensional gait analysis (3dga) that is planned as a routine clinical follow-up at the cmal (clinical motion analysis laboratory), extended with an additional 3dga on the treadmill. the treadmill gait laboratory and overground gait laboratory are across the hall from each other, which makes it possible for the subject to walk from one to the other gait laboratory in just a minute. during the 3dga, kinematic, kinetic and emg-data will be collected.

Eligibility criteria:
inclusion criteria: * gross motor function classification system (gmfcs) level i - iii * cp (bilateral \& unilateral) * age: 6 - 17 years * prescribed afo by the medical team (as part of the standard care) exclusion criteria: * severe contractures or spasticity, which makes it impossible to wear a conventional afo * cognitive or visual impairment that hinder them to understand instructions * previous surgery on bones and/or muscles of the legs in the last 12 months prior to assessment * presence of ataxia or dystonia

Keywords: cerebral palsy rehabilitation gait analysis variability