Kornimate/medical-research-clean huggingface dataset:
clinical outcomes of noses versus traditional robotic-assisted surgery for patients with colorectal cancer

Conditions: Colorectal Neoplasms; Neoplasms Malignant; Complication of Surgical Procedure; Robotic Surgical Procedures; Natural Orifice Specimen Extraction Surgery

Summary: in this study, the investigators will compare the clinical outcomes of the natural orifice specimen extraction surgery versus traditional robotic-assisted surgery in the treatment of colorectal cancer.

based on investigators' experience, compared to robotic-assisted colorectal cancer radical resection, robotic colorectal cancer radical resection with natural orifice extraction has more advantages in postoperative stress response, postoperative pain, postoperative recovery and postoperative abdominal aesthetics. however, in terms of tumor radicality, there may be no obvious differences. there are no randomized controlled trails to discuss these questions.this research is based on the above conditions. investigators use prospective randomized controlled trial to analyze the surgical data, postoperative complications, postoperative recovery of the robotic colorectal cancer radical resection with natural orifice extraction and conventional robotic-assisted colorectal cancer radical resection in order to summarize clinical experience and explore the advantages and disadvantages of robotic colorectal cancer radical resection with natural orifice specimen extraction and to provide a new direction for the surgical treatment of colorectal cancer, which is beneficial to the promotion of noses(natural orifice specimen extraction surgery ) technology and treatment of colorectal cancer.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 and ≤ 80 years; 2. performance status of 0 or 1 on ecog (eastern cooperative oncology group) scale; 3. histological or cytological confirmation of colorectal adenocarcinoma; 4. high rectal and sigmoid cancer with the lower margin of the tumor greater than 10 cm from the anal dentate line; 5. t1-3n0m0 at preoperative evaluation according to the american joint committee on cancer (ajcc) cancer staging manual 8th edition, transvaginal noses procedure w specimen with a circumferential diameter of \<5 cm; 6. preoperative examination did not suggest distant metastasis, implantation or invasion of adjacent organs; 7. cardiopulmonary liver and kidney function can withstand surgery; 8. written informed consent for participation in the trial. exclusion criteria: 1. not suitable for robot laparoscopic surgery; 2. the tumor is too large to be pulled out through the anus or vagina; 3. simultaneous multiple primary cancer; 4. emergency surgery due to complication (bleeding, obstruction or perforation) caused by primary cancer 5. women with acute gynecological infections, vaginal deformities, unmarried and infertile women and women who are married and plan to get pregnant.
neuromuscular consequences of knee arthroscopy

Conditions: Tear of Fibrocartilage of Joint

Summary: to determine changes in quadriceps muscle function following the application of ice and compression to the knee.

novel rehabilitation methods, that specifically target decreased muscle activation due to joint pathology prior to strength training, have elicited greater improvements in muscle function and self-reported disability compared to traditional therapies. preliminary evidence suggests applying cryotherapy to a joint prior to exercise can increase quadriceps activation. it is unknown if applying cryotherapy and intermittent pneumatic compression can also increase quadriceps force output and voluntary activation. the purpose of this study is to determine changes in quadriceps force output and voluntary activation following the application of cryotherapy and compression. the investigators hypothesize there will be an increase in quadriceps force output and voluntary activation following the application of cryotherapy and compression.

Eligibility criteria:
inclusion criteria: * age 15-65 years * bmi \< 30 * candidate for arthroscopic knee surgery to address meniscus pathology or arthroscopic knee surgery within the past 2 years. exclusion criteria: * participants who are outside of age range * ligamentous insufficiency or repair * participants with traumatic spine or lower extremity injury within past 6 months * participants who have had previous adverse reactions to electrical stimulation or cryotherapy (i.e. burns, hypersensitivity) * medical conditions which would be contraindications to electrical stimulation or transcranial magnetic stimulation, including cardiac pacemaker, metal implants in the head, current pregnancy, neurological disorders, and history of seizures * participants who are unable to give consent or are unable to understand procedures of experiment.

Keywords: arthroscopic partial meniscectomy meniscus quadriceps strength quadriceps voluntary activation cryotherapy compression vasopneumatic compression intermittent pneumatic compression
hmg stimulation versus hrt for endometrial preparation prior to blastocyst transfer in moderate to severe iua patients

Conditions: Infertility, Female; Intrauterine Adhesion

Summary: evaluation of endometrial preparation using either human menopausal gonadotrophin (hmg) stimulation and hormone replacement therapy (hrt) prior to blastocyst transfer in patients with moderate to severe intrauterine adhesion (iua).


Eligibility criteria:
inclusion criteria: * bmi 18\~23 kg/m2 * women with moderate to severe iua as defined by the american fertility society classification (1988) * presence of at least 3 cryopreserved cleavage-stage embryos (including 1 good quality) or blastocysts exclusion criteria: * using embryos from donor oocytes * preimplantation genetic diagnosis(pgd)/preimplantation genetic screening(pgs) cycles * moderate or severe endometriosis * untreated unilateral or bilateral hydrosalpinx * uterine adenomyosis, uterine myoma (submucous,intramural myoma \>4 cm),\>1cm septate uterus, double uterus, bicornuate uterus, unicornuate uterus
mobile hiv prevention app for black women

Conditions: Mobile Phone Use; Hiv; Stigma, Social

Summary: black women have a significantly higher risk of acquiring hiv compared to their non-black counterparts. the purpose of this study is to refine and test a mobile hiv prevention and reproductive health app developed specifically for black women.

the overall goal in implementing this study will be to assess the feasibility, acceptability, and usability of the in-the-know mobile app. the app will be refined using preliminary data obtained through prior research with black women in which their perspectives towards the use of an hiv and sexual health mobile app were ascertained. preliminary data obtained from a community advisory board (cab), which will consist predominately of black women will guide refinement of the content and features included within the mobile app, whilst ensuring that the app is tailored towards the needs and perspectives of black women. this will be a randomized study with quantitative data collected through surveys, and qualitative data collected through in-depth interviews.

Eligibility criteria:
inclusion criteria: * 18-44 years of age * self-identify as black * assigned female at birth and identify as female; * individuals who qualify for pre-exposure prophylaxis (prep) based on the centers for disease control (cdc) criteria (for residence in high hiv incident areas-reside in fulton, cobb, gwinnett, or dekalb counties) * sexually active within the last 6 months * hiv-negative * owner of an android or ios smartphone exclusion criteria: * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners * cognitively impaired or individuals with impaired decision-making capacity * individuals who are not able to clearly understand english
teenagers: impact of eccentric exercise training on overweight and obesity

Conditions: Adolescents (12 to 17 Years Old); Obese (BMI>90th Percentile)

Summary: nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle which permits eccentric (ecc) lower limbs contractions at a defined power output. with this type of ergometer, o2 consumption (vo2) in ecc is three fold lower than in concentric (con) for the same power output. consequently, ecc program could be used in chronic disorders with limited capacities, such as obesity. the investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. this effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ecc training (versus con training). this study aims to compare the modification of fat mass after an ecc program versus a con program at the same vo2.. the secondary goal is to assess the physiological mechanisms involved in the modification of body composition.

40 obese adolescents will be randomized into 2 groups: con or exc. the patients of ecc group will follow habituation sessions (2 weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. the training program will last 12 weeks for the two groups. before and after, each subjects will participate to the following measurements: total and segmental body composition (dxa), aerobic capacities (maximal incremental exercise test, vo2max), muscular lower limbs strength (isometric and isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Eligibility criteria:
inclusion criteria: * adolescent (12 to 17 years old) * bmi\>90th percentile * post puberty (tanner 3 to 5) * inactive (\<10 mets/h/week) * no other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no genetic obesity and no contraindication to physical activity exclusion criteria: -

Keywords: pediatric obesity eccentric exercise body composition training program
choicesplus: reducing alcohol- and tobacco-exposed pregnancy

Conditions: Alcohol Use; Smoking; Contraception

Summary: choices plus, a randomized controlled study, will determine the efficacy of the project choices intervention plus a referral to an evidence-based smoking cessation program in reducing the risk of alcohol- and tobacco-exposed pregnancies.

this randomized controlled study will examine the effect of the choicesplus intervention compared to treatment as usual (tau) in: reducing alcohol use below established risk levels; increasing consistent use of effective contraception; increasing engagement in smoking cessation treatment and increasing smoking cessation. in addition, our examination of the incremental costs of the choicesplus intervention (e.g., staff time, materials, administrative services, total medical charges pre- and post-intervention) will provide a basis for future cost/benefit analyses that will inform policymakers and healthcare organizations of the potential benefits of implementing choicesplus. results from this study will inform and advance future efforts in the service of promoting healthy prenatal behavior and reducing the prevalence of alcohol and tobacco-exposed pregnancies.

Eligibility criteria:
inclusion criteria: * have no condition causing infertility * are not pregnant or planning to become pregnant in the next 9 months * have had vaginal intercourse during the previous 3 months with a fertile man without using effective contraception * are drinking at risk levels; and 5) are available for the follow-up period. exclusion criteria: * infertile * pregnant * insufficient locator information * language other than english or spanish

Keywords: alcohol-exposed pregnancy tobacco-exposed pregnancy alcohol contraception smoking pregnancy
a thorough ecg study in subjects with acne vulgaris treated with sb204

Conditions: Acne Vulgaris

Summary: a double-blind, double-dummy, randomized, 4-period crossover study to define the ecg effects of sb204 using a clinical and supratherapeutic dose compared with placebo and moxifloxacin (a positive control) in subjects with acne vulgaris: a thorough ecg study

a double-blind, double-dummy, randomized, 4-period, crossover study to define the ecg effects of sb204 using a clinical and a supratherapeutic dose compared with placebo and moxifloxacin (a positive control) in subjects with acne vulgaris: a thorough ecg study

Eligibility criteria:
inclusion criteria: * moderate to severe acne * 20 inflammatory and 25 non-inflammatory acne lesions exclusion criteria: * pregnant, trying to become pregnant, or nursing * known allergy to any component of the topical sb204 formulation
cytokine and mmp levels in gingival crevicular fluid in the treatment of localized gingival recessions

Conditions: Gingival Recession

Summary: the main objective of this study was to evaluate the matrix metalloproteinase (mmp)-8, and -9, tissue inhibitor of matrix metalloproteinase and interleukin-1beta levels in gingival crevicular fluid during the early and late stages of healing for gingival recession sites treated by coronally advanced flap plus platelet rich fibrin (prf) compared to caf plus connective tissue graft. as prf consists of several growth factors, it may enhance the healing potential of soft tissues, the investigators hypothesized that using prf in the treatment of gingival recessions might regulate inflammation and promote wound healing.

the aim of this study was to evaluate the effect of prf by assessing gingival crevicular fluid (gcf) levels of mmp-8, mmp-9, tissue inhibitor of matrix metalloproteinase (timp-1) and interleukin-1beta (il-1β) during the early and late stages of healing following coronally advanced flap (caf) plus prf or caf plus connective tissue graft (ctg) treatment. primary outcome variables were biochemical parameters, such as: gcf mmp-8, -9, timp-1 and il-1β levels. the secondary outcome variables were change in gingival recession expressed as recession reduction in millimeters at follow-up visits. sample size has been estimated in 24 subjects per treatment groups. random allocation of the treatment sites to test (caf+ prf) and control (caf + sctg) groups will be performed using a computerized selection of random numbers for allocation of the study groups. biochemical parameters: gcf samples were obtained from each recession defect in each subject immediately prior to treatment of recessions and at 10 days, 1 month, 3 months and 6 months after surgery. periodontal parameters including probing depth (pd), clinical attachment level (cal), and gingival recession parameters including recession depth (rd), recession width (rw), and keratinized tissue width (ktw),were assessed by a calibrated examiner. at baseline and at 6 months, pd, rd, rw and ktw were evaluated by clinical assessment. follow-up of subjects: 6 months.

Eligibility criteria:
inclusion criteria: * similar bilateral miller class i or ii localized gingival recessions at least ≥ 2 mm located on incisors, canines or premolars on both jaws * identifiable cementoenamel junction * age ≥ 18 years * presence of tooth vitality and absence of restorations and superficial caries in the area to be treated * no periodontal surgical treatment in the previous 24 months on the involved sites * sufficient palatal donor tissue for the indicated sctg. exclusion criteria: * smoking * patients with a pregnancy or lactation period or self-reported history of antibiotic medication within three months * molar, mobile or teeth with crown or filling were also excluded.

Keywords: gingival recession fibrin connective tissue gingival crevicular fluid matrix metalloproteinase cytokine
if different types of periampullary diverticula affect ercp cannulation?

Conditions: Intubation;Difficult

Summary: to study the influence of different types of periampullary diverticulum(pad) on ercp difficult cannulation and postoperative complications.

periampullary diverticula (pad) are extraluminal out-pouching of the duodenum mucosa often occurring within a radius of 2-3 cm from the ampulla of vater or hepatopancreatic ampulla. more pad cases have been identified over recent years, and it's generally believed that up to 27% of elderly cases may have pad. several classifications of pad have been proposed, and the most commonly used distinguishes intraluminal and extraluminal diverticula. recent studies suggest that pad is a risk factor for the development of bile duct diseases, and it may cause endoscopic retrograde cholangiopancreatography (ercp) procedures to fail, but some other studies have come to the opposite conclusion. during ercp procedures, the investigators found that different types of pad seem to have some differences in the size of the diverticulum, difficulty in intubation, and complications. the investigators plan to this retrospectively study collecting 4 years of cases to evaluate the clinical features of different types of pad in terms of difficult cannulation and complications.

Eligibility criteria:
inclusion criteria: * 18-90 years old ercp patients * with native papilla exclusion criteria: * unwillingness or inability to consent for the study * coagulation dysfunction (inr\> 1.5) and low peripheral blood platelet count (\<50×10\^9 / l) or using anti-coagulation drugs * previous ercp * prior surgery of bismuth ⅱ, roux-en-y and cholangiojejunostomy * preoperative coexistent diseases: acute pancreatitis, gi tract hemorrhage or perforation, severe liver disease(such as decompensated liver cirrhosis, liver failure and so on), septic shock * biliary-duodenal fistula confirmed during ercp * pregnant women or breastfeeding

Keywords: ercp periampullary diverticula difficulty cannulation complication biliary disorder
implementing surgery school prehabilitation using telehealth

Conditions: Lung Cancer; Colorectal Cancer; Oesophageal Cancer; Pancreas Cancer; Gastric Cancer

Summary: the physiological challenge of major surgery has been likened to running a marathon. in both cases, preparation is critical. yet, many patients undergo major surgery without understanding the potential consequences. the sttarrs trial aims to test the effect of an education program delivered via telehealth in people preparing for lung or major abdominal cancer surgery , compared with usual care on the development of a respiratory complications after surgery. the secondary aims will be to determine the effect of the online education program for people preparing for lung or major abdominal cancer surgery compared to usual care on the following outcomes; acute hospital length of stay, surgical recovery, physical function and activity, self-efficacy, behaviour change, symptoms, health-related quality of life, number of days alive and out of hospital and health service usage and survival. this trial includes one sub-study. the sub-study will recruit eligible people preparing for lung cancer surgery. in the sub-study, 65 participants will receive an individualised inspiratory muscle training and walking program delivered and monitored by telehealth in addition to the main sttarrs trial intervention before surgery.


Eligibility criteria:
inclusion criteria: * preparing for lung cancer (open or video assisted) or major abdominal cancer surgery (upper gi, hepatobiliary and colorectal, open or video assisted). * provide consent * have primary treating surgeon approval * proficient in english to understand testing, video interventions as well as outcome assessments. exclusion criteria: * concurrent, actively treated other malignancy of history of other malignancy treated within the past year, * severe or unstable psychiatric, cognitive or substance abuse disorders, such that precludes informed consent or interferes with cooperation with trial requirements or current inpatients.
initial experience with a new laparoscopic based robotically assisted surgical system for cholecystectomy

Conditions: Biliary Colic; Cholecystitis

Summary: the senhance™ surgical robotic system, previously known as telelap alf-x (transenterix, morrisville, nc, usa) has recently become available in the uk. it aims to provide the robotic benefits of greater accuracy, dexterity and control with similar operational costs to traditional laparoscopy. patients randomly received either a standard laparoscopic cholecystectomy or the senhance assisted cholecystectomy based on scheduled surgery date. a prospectively maintained database of the first 20 patients undergoing cholecystectomy with the senhance surgical system was retrospectively interrogated and compared to a concurrently treated group of 20 laparoscopically treated patients during the same timeframe.


Eligibility criteria:
inclusion criteria: asa i or ii confirmed diagnosis of biliary colic or cholecystitis normal lfts exclusion criteria: patients unable tor unwilling to consent bmi \>40

Keywords: robotic surgery
safety and pharmacokinetic study of inhaled esketamine in healthy volunteers

Conditions: Healthy Volunteers

Summary: the planned study is to determine the pharmacokinetic properties of esketamine and safety assessment with inhaled esketamine after different number of inhalations and different dosing sequences within three parts of the study.

this is to be one-centre, single ascending dose and double-blind placebo controlled multiple dose three part study of esketamine dpi (dry powder inhaler) in healthy volunteers. part a is a single dose, open-label part with esketamine dpi inhalations administered with dose escalation between cohorts. part b is a single dose, open-label part with esketamine dpi inhalations administered in different dosing sequences with dose escalation between cohorts. part c is a multiple dose, double-blind, placebo-controlled part with esketamine dpi inhalations administered in different cycles of treatment (with four dosing sequences within two weeks) with dose escalation between cohorts. participants in this part will be randomized to receive esketamine dpi or placebo in 3:1 ratio. pharmacokinetic properties and safety of esketamine dpi will be determined following different number of inhalations in part a, different dosing sequences in part b and different cycles of treatment in part c.

Eligibility criteria:
inclusion criteria: * caucasian female or male, * age: 18-55 years old, inclusive, * body-mass index (bmi): ≥18.5 kg/m\^2 and \<29.9 kg/m\^2 * non-smoker and nonuser of tobacco products for at least 1 year before screening, * physical examination without any clinically relevant abnormality, * laboratory values not clinically significant, * volunteer (or his/her partner) of childbearing potential willingness to use acceptable forms of contraception. exclusion criteria: * known allergy or hypersensitivity to ketamine or its derivates and/or to any study product excipients, * any known significant current or past acute or chronic disease or condition, * participation in other clinical trial within 90 days preceding the screening, * blood drawn within 30 days prior to inclusion to the study (more or equal to 300ml), * positive results from pregnancy test for female participants, * lactation in women participants, * hypotension or hypertension in medical history, * narcotic, alcohol addiction or abuse, * participant who adhere to a special diet (e.g. low calories, vegetarian).