Kornimate/medical-research-clean huggingface dataset:
"the map study": mapping the patient journey in mma and pa

Conditions: Methylmalonic Acidemia; Propionic Acidemia

Summary: longitudinal, exploratory, natural history study of patients with mma due to mut deficiency and pa to characterize the changes in blood disease biomarkers over time and the frequency and severity of clinical events related to their disease.


Eligibility criteria:
inclusion criteria: mma only • patient has a confirmed diagnosis of isolated mma due to mut deficiency (mut0 or mut-) based on the following criteria: * elevated plasma/serum/dbs or urine methylmalonic acid levels * presence of normal serum/plasma vitamin b12 and plasma homocysteine levels * confirmed by molecular genetic testing. genetic testing can be performed after the administration of informed consent if not available, however, molecular genetic results must be confirmed before the second study visit pa only • patient has a confirmed diagnosis of isolated pa based on the following criteria: * elevated plasma/dbs/urine 2-mc and/or 3-hp * elevated plasma/serum/dbs propionylcarnitine (c3) * confirmed by genetic testing for mutations of the pcca or pccb genes. genetic testing can be performed after the administration of informed consent if not available, however, molecular genetic results must be confirmed before the second study visit both mma and pa * patient (and/or legally authorized representative as applicable to local regulations) is willing and able to comply with study-related assessments and activities * patient or legally authorized representative is willing and able to provide informed consent and/or assent as mandated by local regulation exclusion criteria: * estimated gfr \<30 ml/min/1.73m2 based on age appropriate equations or patients who undergo chronic dialysis * the patient is pregnant or lactating at the time of screening. (note: patients who become pregnant during the study may remain in the study) mma only * patients diagnosed with isolated mma cbla, cblb, or cbld enzymatic subtypes or methylmalonyl-coa epimerase deficiency or combined mma with homocystinuria pa only * patient has a confirmed diagnosis of multiple carboxylase deficiency

Keywords: methylmalonic acidemia mma organic acidemia mut deficiency inborn errors of metabolism mut0 mut- pa pcca pccb propionic acidemia
genetics of obesity in chinese youngs

Conditions: Obesity; Metabolic Syndrome

Summary: the purpose of this study is to explore the pathogenesis and genetic susceptibility of obese subjects,providing a convincing argument for further treatment of obesity and metabolic syndrome.

obesity has become a major worldwide challenge to public health, owing to an interaction between the obesogenic environment and a strong genetic contribution.previous studies found that genetic factors determine 40%-70% of obese phenotype.under such circumstances, the screening of obesity susceptibility gene is particularly important for society or family to take measures to prevent obesity. recent extensive genome-wide association studies(gwass) have identified numerous single nucleotide polymorphisms associated with obesity,but these loci together account for only a small fraction of the known heritable component.two studies in 2010 nature,for the first time, put rare copy number variation (cnv)in association with severe early-onset obesity.their significance lie not only in the discovery of the pathogenic genes of severe early-onset obesity but,more importantly,in providing new strategies for finding out genes that cause complex diseases. obese patients and healthy lean controls proved by a series of blood biochemical examinations will be enrolled in this study.the present study intends to use the techniques such as enzyme-linked immunosorbent assay, real-time fluorescence quantitative pcr,gene chip,construction of viral vectors,transfection, taking advantage of the established database,by means of serum assays and functional tests, associate copy number variation with obesity phenotype to explain the root cause of obesity.meanwhile biomarkers, gut flora and genetic risk factors will be evaluated in the study subjects.

Eligibility criteria:
inclusion criteria: * body mass index (bmi)≥ 30kg/m2 * predominantly east china to minimize population stratification * willing and able to provide informed consent exclusion criteria: * pregnancy/lactation * cushing syndrome * hypothyroidism * obesity caused by pituitary and hypothalamic lesions * drug related obesity * history of major psychiatric illness

Keywords: obesity metabolic syndrome genetic risk markers copy number variation
the hpv self-test as a test of cure in madagascar

Conditions: Human Papilloma Virus Infection; Cervical Intraepithelial Neoplasia Grade 2/3

Summary: the purpose of this study is to find out whether self-hpv may be an accurate method for the follow-up of women with a history of hpv infection.

the efficacy and the availability of cold coagulation render it a valuable technique for the treatment of precancerous lesions in low-resource settings. the human papillomavirus (hpv) test performed by women themselves (hpv self-test) could be an efficient method to assess the long-term risk of recurrent/persistent disease in women with a history of hpv infection and cervical intra-epithelial lesions grade 2 or higher (cin2+). a total of 443 hpv-positive women, aged 30-65 years, have been selected through a screening campaign conducted in ambanja, madagascar, between 2013 and 2015. of these, 260 have been treated by cold coagulation, conisation or electrocauterization. a follow-up visit at 1-3 years after primary screening will be organized for all hpv-positive women detected at primary screening. participants will perform an hpv self-test. a sample for cytology and hpv testing will also be collected by the physician. the goal of the study will be the histological search for cin2+ lesions at one to three years after primary screening. the investigators expect to see that self-hpv may be an accurate method for the follow-up of women with a history of hpv infection.

Eligibility criteria:
inclusion criteria: * women previously positive at hpv testing exclusion criteria: * pregnancy
a study to evaluate efficacy and safety of methacholine chloride challenge test in diagnosis of adult asthma

Conditions: Asthma

Summary: the purpose of this study is to evaluate efficacy and safety of methacholine chloride challenge test in diagnosis of adult asthma


Eligibility criteria:
inclusion criteria: * fev1/forced vital capacity(fvc) must be 70% or more * \<10% decrease in fev1 in response to inhalation of normal saline exclusion criteria: * moderate airflow limitation (fev1 \< 60% predicted or \< 1.5 l) * heart attack or stroke in last 3 months * uncontrolled hypertension, systolic bp\>200, or diastolic bp\>100
isolation of cells from biopsy tissue to aid in kidney repair

Conditions: Kidney Diseases; Endothelial Dysfunction

Summary: endothelial progenitor cells that reside in renal vasculature may be stimulated to initiate differentiation programs during episodes of injury. it is hypothesized that endothelial progenitor cells resident in the kidney can transition to a post-injury phenotype that promotes endothelial repair.

endothelial dysfunction is central to the pathophysiology of vascular ischemia, bacterial sepsis, toxin-induced thrombotic microangiopathy, and antibody-mediated kidney transplant rejection and often manifest with renal failure. with each of these diagnoses circulating components of the complement cascade bind to endothelial cells and induce disease progression through anaphylactic cellular messaging, monocyte homing, and direct cell membrane disruption. in response to injury during embryologic development avascular metanephric blastema initiate endothelial differentiation. although circulating hematopoietic progenitor cells have shown therapeutic promise they incorporate into renal vasculature at very low density.

Eligibility criteria:
inclusion criteria: * only patients who have a clinical indication for kidney biopsy will be considered. * all subjects will be at least 18 years of age and may be of any gender. * patients undergoing a native or kidney transplant biopsy will be considered. exclusion criteria: * patients not undergoing a kidney biopsy will be excluded.
time to diagnosis of glenohumeral joint dislocations in the ed- traditional radiography vs. poc ultrasound

Conditions: Glenohumeral Dislocation

Summary: this is study to compare the time to diagnosis of glenohumeral joint dislocation using two imaging methods, traditional x-ray and point-of-care ultrasound. participants who present at the emergency department complaining of shoulder injury and who are suspected of having a possible glenohumeral shoulder dislocation will be eligible for the study. a reduction of the joint will be performed if imaging findings so indicate. all participants will receive a post-reduction x-ray and be referred to appropriate follow-up care.

this is a prospective comparison study evaluating the time to diagnosis of glenohumeral joint dislocation using two imaging modalities, traditional x-ray and point-of-care ultrasound. eligible participants will include those who present to the emergency department with complaints of shoulder injury who are suspected by triage nursing of having a possible glenohumeral shoulder dislocation. eligible participants will be consented by participating physicians and randomized into ultrasound or x-ray groups. if indicated based on the imaging findings, a reduction of the joint will be performed. all patients will receive a post-reduction x-ray and be referred to appropriate follow-up care based on the findings of their evaluation.

Eligibility criteria:
inclusion criteria: * adult patients (19 and older in state of nebraska) who present to the emergency department with shoulder pain/injury and potential shoulder dislocation exclusion criteria: * injury sustained in major traumatic event (trauma activation), unable to consent, in extremis, less then 19 years of age

Keywords: glenohumeral dislocation poc ultrasound plain radiograph
weight loss impact on male fertility

Conditions: Obesity; Sub Fertility, Male; Metabolic Syndrome

Summary: this is a prospective non-randomized unicentric clinical trial, characterized by the inclusion of obese (bmi\> 35) male with subfertility (sperm count showing low sperm counts and / or motility and / or morphology and / or dna fragmentation). patients selected at the endocrinology obesity hc-fmusp outpatient will be submitted to very low calorie diet (vlck) for 6 months, being reassessed clinically and laboratorially monthly.


Eligibility criteria:
inclusion criteria: obesity in male patients * metabolic syndrome (ncep-atp iii) * alteration of some of the seminal parameters evaluated in conventional seminal analysis exclusion criteria: * other causes of hypogonadotrophic hypogonadism * hypergonadotrophic hypogonadism * contraindications for performance of ketogenic diet: * type 1 or type 2 diabetes mellitus in insulin use * food drive * alcoholism or drug addiction * severe psychiatric illness * use of coumarin anticoagulants * hepatic insufficiency * severe renal impairment * hematologic diseases * cancer in activity, * cardiovascular or cerebrovascular diseases (arrhythmias, recent myocardial infarction, unstable angina, decompensated heart failure, recent stroke) * gout * renal or biliary lithiasis * major depression or other serious psychiatric illness.
elderly urinary incontinence caregiver burden

Conditions: Caregiver Burden; Urinary Incontinence

Summary: the purpose of this study is to evaluate the severity of urinary incontinence (ui) in elderly patients and its impact on the burden of care in their family caregivers.

the objective was to evaluate the severity of urinary incontinence (ui) in elderly patients and its impact on the burden of care in their family caregivers. the study is a descriptive, cross-sectional and relationship-seeking type of research. it was conducted prospectively with 80 elderly(≥65 years of age) patients with ui and their family caregivers who applied to the urology clinic between june and december 2021. the data was collected using the "socio-demographic characteristics data collection form". ui was assessed by "international consultation on incontinence questionnaire short form(iciq-ui-sf)" and caregiver burden by means of zarit burden scale(zbi) form.

Eligibility criteria:
inclusion criteria: * the primary caregiver family member (mother, father, spouse, sibling, child), appropriate cognitive and mental health to respond to the applied forms, constant patient care * the patient's being 65 years and older and diagnosed with urinary incontinence. exclusion criteria: * the family member who did not volunteer to participate in the study

Keywords: urinary incontinence elderly patient family member caregiver caregiver burden
acetazolamide for the prevention of high altitude illness: a comparison of dosing

Conditions: Prophylaxis of Acute Mountain Sickness

Summary: this is a phase 4, randomized, double-blinded interventional trial comparing alternative doses of acetazolamide for the prevention of high altitude illness.

acetazolamide, or diamox, is the standard medical prophylaxis agent for high altitude illness. the medication is effective in preventing acute mountain sickness (ams), high altitude pulmonary edema (hape), and high altitude cerebral edema (hace). its mechanism is via inhibition of the carbonic anhydrase enzyme which counteracts the respiratory alkalosis which occurs during ascent to altitude. it facilitates the excretion of bicarbonate in the urine. as a result, acetazolamide hastens acclimatization and helps prevent high altitude disorders. current recommended dosing is 125 mg, orally twice daily, started 24 hours prior to ascending in elevation. side effects include tingling of the fingers and toes and perioral numbness which may be erroneously interpreted as stroke symptoms. since acetazolamide is a mild diuretic, frequent micturition may occur leading to interruption of daytime activities as well as broken sleep. these effects can affect safety at high altitude. acetazolamide is normally discontinued 2 days after the user has reached their highest elevation or a plateau in elevation. a lower dose may be just as effective in preventing high altitude illnesses while preventing the disconcerting side effects resulting from its use. a smaller dose has not been studied, however. we will compare the common dose of 125 mg twice daily with a lower dose of 62.5 mg twice daily.

Eligibility criteria:
inclusion criteria: * 18 years or older * english or indian speaking * mountaineers or trekkers who plan to climb mt. mckinley or trek to base camp on mt. everest exclusion criteria: * low sodium and/potassium blood serum levels * kidney disease or dysfunction * liver disease, dysfunction, or cirrhosis * suprarenal gland failure or dysfunction * hyperchloremic acidosis * angle-closure glaucoma * taking high dose aspirin (over 325 mg/day) * any reaction to sulfa drugs or acetazolamide * pregnant or lactating women
the impact of post discharge one-time home visit: bridging the gap between hospital and home.

Conditions: COPD; Coronary Artery Disease; Diabetes Mellitus; Stroke

Summary: a single post-hospital discharge home visit by a geriatric nurse practitioner or geriatric fellow can bridge the gap and ease the transition for elderly frail patients returning home after hospital admission. we believe this intervention will reduce medication errors, ensure follow-up discharge plans, decrease re-hospitalization rates, and decrease morbidity and mortality.


Eligibility criteria:
inclusion criteria: patients admitted to the ace unit during the study time frame, age 65 and over, and residing in the community before and after discharge from the hospital. selected patients will have complex discharge plans including referrals to home care agencies, poly-pharmacy, multiple co-morbidities, history of repeated hospitalizations, and poor social support systems in the community. in addition, eligible patients will have at least one of eight admitting diagnoses, chosen for their high likelihood of requiring post-discharge home care needs. these diagnosis include: chf, copd, coronary artery disease, diabetes mellitus, stroke, hip fracture, peripheral vascular disease or cardiac arrhythmia. the gnp or fellow will then request permission from the patient's primary physician to do a one-time post-discharge home visit. exclusion criteria: patients discharged to settings other than their homes (i.e. nursing home, sub-acute rehabilitation, etc.)patients discharged to settings other than their homes (i.e. nursing home, sub-acute rehabilitation, etc.)
a research study to look at how well cagrisema helps people living with obesity lose weight and maintain weight loss in the long-term

Conditions: Obesity

Summary: this study will look at how well cagrisema helps people living with obesity to lose weight and maintain the weight loss long-term. the study has 2 parts: the first part is called 'the main study' and the second part is called 'the extension study'. in the main study participants will either get cagrisema (a study medicine) or placebo (a dummy medicine that looks like cagrisema but has no active ingredient). which treatment participants get is decided by chance. participants are two times more likely to get cagrisema than placebo. if participants get cagrisema in the main study, participants will continue on cagrisema in the extension study. which dose of cagrisema participants will continue on is decided by chance. if participants get placebo in the main study, participants will get cagrisema in the extension study. participants will take one injection of study medicine once a week. the study will last for about 3 years and 3 months.


Eligibility criteria:
key inclusion criteria: * male or female (sex at birth). * age 18 years or above at the time of signing the informed consent. * bmi ≥ 30.0 kilogram per square meter (kg/m\^2) at screening. * participant has a wish to lose at least 25% of body weight within 80 weeks from randomisation. key exclusion criteria: * glycated haemoglobin (hba1c) ≥ 6.5% (48 millimole per mole \[mmol/mol\]) as measured by the central laboratory at screening. * history of type 1 or type 2 diabetes.
multimarker approach for acute dyspnea in elderly patients admitted in the emergency department

Conditions: Acute Dyspnea; Acute Heart Failure

Summary: elderly people constitute the largest proportion of emergency department (ed) patients, representing 12% of all ed admissions. the need for diagnostic tests or therapeutic interventions is much greater in this patient population. cardiovascular diseases and symptoms represent 12% of the causes for ed admission, and patients suffering from cardiovascular disease are those whose ed visit lasts longest. the diagnostic approach in the ed in elderly patients admitted for acute dypsnoea is complex, and early identification of acute left-sided heart failure (alshf) is vital as it has an impact on prognosis. the clinical signs are difficult to interpret, and are non-specific, particularly at the acute phase and in elderly or obese patients. indeed, some authors have reported up to 50% of diagnostic errors in elderly patients. measure of the blood concentration of a natriuretic peptide allows a quick diagnosis. however, peptides alone suffer from several limitations, particularly in situations that are often encountered in elderly patients, such as sepsis, renal failure, acute coronary syndrome, pulmonary embolism, chronic respiratory failure, atrial fibrillation and high body mass index. diagnostic performance deteriorates with increasing age, and there is a significant increase in this grey-zone in patients aged ≥75 years. in critical situations in elderly patients, assessment of natriuretic peptides serve mainly to rule out a diagnosis of left heart failure. some authors have studied other biomarkers showing their performance in the diagnosis of alshf. these are biomarkers involved in remodeling and myocardial fibrosis (st2, galectin-3) or involved in myocardial injury (high-sensitivity troponin-i). therefore, a combined "multimarker" approach could improve the diagnostic performance of alshf. read (nct02531542) is a diagnostic study including patients over the age of 75 admitted to acute dyspnea in the ed, to demonstrate the superiority of an ultrasound protocol (the read protocol) on nt-probnp in the alshf diagnosis. the hypothesis is that the diagnostic accuracy of a multimarker diagnostic approach, namely the read-ma method, combining nt-probnp, high-sensitivity troponin-i, st2 and galectin-3 would be superior to that of nt-probnp assessment for the diagnosis of alshf in elderly patients (≥75 years) admitted to the ed.


Eligibility criteria:
inclusion criteria : * admission to the emergency department with age ≥ 75 years * and criteria of acute dyspnea : breathe rate ≥ 25 cycles/minute or pao2 ≤ 70 mmhg or spo2 ≤ 92% in room air or paco2 ≥ 45 mmhg and ph ≤ 7.35 - and electrocardiogram in sinus rhythm or in atrial fibrillation at admission exclusion criteria: * none
evaluation of techniques for scaling and root planing and one stage full mouth disinfection

Conditions: Periodontal Disease; Chronic Periodontitis

Summary: evaluate and compare the effectiveness in a clinical and microbial perspective one stage full-mouth disinfection technique in relation to scaling and root planing per quadrant associated with chlorhexidine or azithromycin.

seventy -seven systemically healthy subjects with chronic periodontitis were randomly included in 6 different predefined groups. the following periodontal parameters were evaluated: probing depth , clinical attachment level , plaque index, gingival index and percentage of areas affected by periodontal disease. microbiologically were evaluated the bacterial load and specific load of five bacterias: the quantification of the bacteria was performed by real-time polymerase chain reaction . the clinical and microbial baseline evaluations were performed ( periodontal pre- therapy) , 90 and 180 days after treatment.

Eligibility criteria:
inclusion criteria: * diagnosis of slight-moderate chronic periodontitis exclusion criteria: * those who were making regular use of antibiotics or anti-inflammatory drugs or had done up to three months before the beginning of the study; * those who were making regular use (twice a day) of oral rinses with chlorhexidine or essential oils or have made regular use within three months prior to study entry; * individuals with a history of sensitivity to chlorhexidine or azithromycin; * subjects undergoing periodontal therapy include dental scaling procedures in the 12 months preceding the start of the study; * subjects with impaired bifurcation or trifurcation class iii; * who required antibiotic prophylaxis for conducting clinical periodontal examination * subjects with removable partial dentures and removable or fixed orthodontic appliance.

Keywords: periodontal disease therapy anti-bacterial agents randomized controlled trials
study of eltrombopag in platelet refractory thrombocytopenia

Conditions: Thrombocytopenia

Summary: this phase ii trial is studying the effects of the drug eltrombopag has on thrombocytopenia (low platelet count). eltrombopag is approved by the fda for the treatment of thrombocytopenia (low platelet count) in adults who have had an insufficient response to medications such as corticosteroids and immunoglobulins. eltrombopag is not approved by the fda (food and drug administration) for the treatment of thrombocytopenia refractory to platelet transfusion and so for this study is considered investigational.


Eligibility criteria:
inclusion criteria: * laboratory diagnosis of platelet refractoriness * diagnosis of platelet dependence * adequate liver and renal laboratory screening tests exclusion criteria: * patients with thrombocytopenia that are responsive to platelet therapy * patients actively receiving intravenous immunoglobulin, plasmapheresis or cytotoxic medications for thrombocytopenia

Keywords: platelet refractory thrombocytopenia