Kornimate/medical-research-clean huggingface dataset:
role of pulse co-oximetry for detecting carbon monoxide poisoning in the prehospital emergency medical service setting

Conditions: Carbon Monoxide Poisoning

Summary: the rad-57 pulse co-oximeter is a lightweight device allowing non-invasive measurement of blood carboxyhemoglobin. previous studies comparing rad-57 measurements (spco) to standard laboratory blood gas analysis (cohb) have reported contradictory results. the rad-57 pulse co-oximeter could be useful as a first-line screening test for acute co poisoning, enabling rapid detection and management of patients with suspected co poisoning in the prehospital emergency setting this study assesses the diagnostic value of pulse co-oximetry, comparing spco to standard laboratory blood measurement for prehospital management of patients with suspected carbon monoxide (co) poisoning.

transcutaneous spco will be obtained using the rad-57 simultaneously with blood sampling for laboratory blood gas analysis, at the time of prehospital management by emergency medical services. the diagnostic performance of spco for the screening of co poisoning will be determined using roc curve analysis, and blood cohb levels \>5% and 10% as the reference standard for co poisonning for non-smokers and smokers respectively. correlation between spco and cohb will be assessed using bland and altman's method.

Eligibility criteria:
inclusion criteria: * patient aged 18 years or older * patient managed by prehospital emergency medical services. * patient with a suspected co exposure presenting or not with clinical signs of co poisoning exclusion criteria: * patient for whom venous blood sampling cannot be obtained prehospitally * patient for whom spco measurement cannot be performed prehospitally (cardiac arrest, peripheral vasoconstriction)

Keywords: co poisoning co-oximetry pulse oximetry carbon monoxide saturation (spco) emergency department sensitivity specificity
an integrative intervention for loss of control eating among adolescent girls

Conditions: Binge Eating/Loss of Control Eating

Summary: this study aims to develop a manualized and culturally sensitive intervention for adolescent girls targeting binge and loss of control (loc) eating. the investigators will evaluate the feasibility and acceptability of the intervention in a controlled pilot trial. the investigators hypothesize that this intervention will serve to reduce binge and loc eating, as well as improve psychosocial functioning as evidenced by decreased depression, anxiety, eating disorder cognitions, and impulsivity, and improved quality of life.


Eligibility criteria:
inclusion criteria: * currently meeting criteria for loss of control (loc) eating or binge eating disorder (bed) as defined by marcus and kalarchian * age 13-22 * female * lives with parent/primary caregiver most of the time exclusion criteria: * alcohol or drug dependence in the last three months * current suicidal intent or clinically significant self-harm behaviors reported during the assessment * diagnosis of bulimia nervosa or anorexia nervosa in the last three months * presence of a developmental disability or neurological impairment that would impair the individual's ability to participate in the intervention * psychosis, including schizophrenia, or bipolar i disorder * not fluent in english (participant and parents/primary caregivers

Keywords: binge eating loss of control eating eating in the absence of hunger emotional eating
effectiveness of video based games on upper extremity functions in mild mental retardation diagnosed cases

Conditions: Mental Retardation; Upper Extremity

Summary: with leap motion controller, virtual reality exercises have been implemented more often since 2014, and this technology has benefited more from upper extremity rehabilitation in literature, there are no publications investigating the effectiveness of virtual reality applications on upper extremity functions in cases of mental retardation with leap motion. we think that virtual reality applications with leap motion are effective in fine motor skills and grip strength in cases of mental retardation. the purpose of our work; to investigation of the effectiveness of video based games on upper extremity functions in mild mental retardation diagnosed cases

for the study group, in addition to fine motor skills activities, 20 min. leap-motion virtual reality games, and for the control group only fine motor skill activities will be applied. the study will last 8 weeks, 2 times a week for a total of 16 sessions.the games that fizyosoft has built on leap motion equipment will be played individually and will focus on running hand, wrist and grip movements to improve hand and grip activities of the events. each game is designed to develop a different hand movement. in this study, catchapet and leapball of fizyosoft handrom products will be used. "leapball," aiming at throwing the ball in the same color as the ball, and leap motion sensor games, "catchapet," aimed at touching the rabbits out of the holes with repeated wrist flexion / extensional movements, will be preferred by grasping a virtual ball with the fingers of all fingers. the demographic characteristics of all the cases participating in the study will be recorded. jebson hand function test, manual ability classification system (macs), 9 hole peg test to measure fine hand skill. jamar hand dynamometer to measure hand grip force, pinchmeter to measure finger grip strength. the evaluation will be repeated before and after the treatment.

Eligibility criteria:
inclusion criteria: * he / she has been diagnosed with mild mental retardation being between 5 and 18 years of age ability to adapt to exercises no epileptic epilepsy no cardiac or orthopedic disturbance exclusion criteria: * being healthy not be between 5-18 years
leveraging chatbot to improve prep in the southern united states

Conditions: HIV Prevention; PrEP Awareness; PrEP Uptake

Summary: the purpose of this study is to develop a chatbot intervention to promote prep awareness and uptake among black men who have sex with men (msm) in the southern united states.

in the united states (us), the epicenter of the hiv epidemic is in the south. the hiv-related death rate in the us south is high, but engagement with quality hiv prevention services and care is low. although only 38% of the us population lives in the south, the region accounts for 51% of new hiv infections. gay, bisexual, and other men who have sex with men (msm) account for 60% of new infections among african americans in the south. black msm are one of the most vulnerable groups to hiv transmission in the us. hiv testing and prep uptake in black msm, however, remain low (10%) due to multiple factors including stigma, sexual-orientation based discrimination and low prep awareness among black msm. innovative strategies that motivate and provide guidance for prep among black msm in the us south are therefore urgently needed. chatbot technology should be tested and implemented to help improve prep awareness and uptake in the us south. in this project, the investigators aim to develop and pilot test to assess the acceptability and feasibility of a chatbot for prep awareness and uptake relative to treatment as usual (control).

Eligibility criteria:
inclusion criteria: * being cisgender black male * being aged ≥ 18 years * having internet access * speaking english * self-reporting condomless sex with another man in the past 6 months * hiv negative or untested. exclusion criteria: * having lived in the us south less than 3 months * having received antiretroviral therapy (art) treatment.
a study of medi7352 in painful osteoarthritis of the knee

Conditions: Chronic Pain

Summary: the purpose of this study is to assess the safety, drug levels and effects on the body of medi7352, in subjects with painful osteoarthritis of the knee.

an interleaved sad/mad study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of medi7352 in subjects with painful osteoarthritis of the knee.

Eligibility criteria:
inclusion criteria: * male and female subjects with painful osteoarthritis (oa) of the knee. female subjects must be postmenopausal or surgically sterile. * body weight between 50kg and 145kg * willing and able to comply with the requirements of the protocol exclusion criteria: * current treatment with another biologic therapeutic agent * current of historical diagnosis of ra * current diagnosis of an immunological condition that is associated with another form of arthritis in addition to oa, including traumatic arthritis or a seronegative spondyloarthropathy * at risk of destructive arthropathy, including rapidly progressive osteoarthritis (rpoa), osteonecrosis, spontaneous osteonecrosis of the knee, subchondral insufficiency fractures, hip dislocation and pathological fracture * presence of clinically significant neuropathy or other clinically significant disorder involving abnormal peripheral sensation. * current serious or unstable clinically important illness.
staff nurse perceptions of mbt skills training for working with bpd in amh

Conditions: Borderline Personality Disorder

Summary: despite expert opinion unconvinced of any value for hospitalization in caring for people with borderline personality disorder (bpd), this patient group still accounts for a significant proportion of adult acute mental health (amh) admissions. staff nurses generally voice negative perceptions of bpd, a view which is linked to an uncertainty of how to approach these patients, and difficulties leading to personal distress and burnout. mentalization-based treatment (mbt) is an evidence based approach, focusing on the mental states of both self and others, developed specifically to treat bpd and facilitated successfully in specialised settings. mbt skills training is a compact and cost effective two day workshop which equips generalist mental health nurses with a skillset enabling them to work effectively with bpd. mbt skills training was first offered to staff nurses in royal cornhill hospital, aberdeen in 2013. this study aims to assess staff perceptions on the value of mbt skills training, evaluating how it impacts on clinical practice when working with bpd in amh.

methodology: using two focus groups with a neutral facilitator, a purposive sample of nine staff nurses took part in a semi-structured exploration of bpd in amh. participants discussed challenges with patients and the impact of mbt skills training and clinical supervision (cs). the focus groups were audio recorded and transcribed verbatim. data was examined using a thematic analysis.

Eligibility criteria:
inclusion criteria: * staff nurses aged between 18 and 65, who had completed the 2 day mentalization based treatment (mbt) skills training and were still working in acute mental health. exclusion criteria: * staff nurses under 18 or over 65, who had not completed the 2 day mentalization based treatment (mbt) skills training and were not working in acute mental health.

Keywords: borderline personality disorder mentalization based treatment mbt skills training staff nurse perceptions acute mental health
efficacy and safety study of stemchymal® in polyglutamine spinocerebellar ataxia

Conditions: Cerebellar Ataxia

Summary: the purpose of the clinical trial is to study the therapeutic efficacy and safety of stemchymal® infusions for polyglutamine spinocerebellar ataxia treatment by a randomized, double-blind, placebo-controlled study design. eligible subjects will receive stemchymal® through intravenous infusion.


Eligibility criteria:
inclusion criteria: 1. subjects are with genotypically confirmed spinocerebellar ataxia type 2 or spinocerebellar ataxia type 3. 2. subjects' baseline sara score are in the range of 8 to15. 3. subjects are between 20 and 70 years of age. 4. subjects who had signed informed consent. exclusion criteria: 1. subjects had been enrolled in any kind of cell therapy within six months prior to screening visit. 2. females with a positive pregnancy test result. 3. subjects who had had severe vital organ disease as diagnosed, including but not limited to cardiac (ex. heart failure), liver (ex. acute hepatic failure or chronic liver cirrhosis), lung (ex. respiratory failure) and renal (ex. hemodialysis or peritoneal dialysis) insufficiency, within six months prior to screening visit. 4. subjects with immunological disorders (ex. systemic lupus erythematosus), within six months prior to screening visit. 5. subjects with other neurological disorders (ex. alzheimer's disease), within six months prior to screening visit. 6. subjects who had received chemotherapy/radiotherapy within five years prior to screening visit. 7. subjects with any history of malignancy tumors. 8. subjects with a history of hypersensitivity/allergy to penicillin. 9. subjects with dementia or other psychiatric illnesses, including but not limited to disabling depression, bipolar disorder, and schizophrenia. 10. subjects with beck depression inventory second edition (bdi-ii) score over 20 points. 11. subjects with unstable illnesses or contraindication for this clinical trial according to pi's judgment.

Keywords: stem cells adult stem cells spinocerebellar ataxia steminent
efficacy of bi-level espb application in patients undergoing vats

Conditions: Pain, Postoperative; Thoracic Surgery, Video-Assisted; Erector Spinae Plane Block; Multimodal Analgesia

Summary: video-assisted thoracic surgery (vats) has become a common procedure in thoracic surgery. severe postoperative pain may be encountered in patients undergoing vats. analgesic methods such as thoracic paravertebral block (tpvb), intercostal block and erector spina plane block (espb) are widely used for vats. among these methods, ultrasound (us) guided tpvb is the most preferred method. in recent years, the frequency of application of plane blocks as a component of multimodal analgesia has been increased. espb is one of them. although there are publications showing that single-level espb applied from the t5 vertebra level spreads in the craniocaudal t3-l2 range, there are also publications stating that the spread is more limited. this study, it was aimed to compare the efficacy of bi-level espb application and one-level espb application for postoperative analgesia in patients undergoing vats.


Eligibility criteria:
inclusion criteria: * age between 18 and 80 years * american society of anesthesiologists physical status i-ii-iii * body mass index between 18-40 kg/m2 * patients undergoing elective video-assisted thoracoscopic surgery exclusion criteria: * patient refusing the procedure * history of chronic analgesic or opioid therapy * history of local anesthetic allergy * infection in the intervention area * emergency surgery
ins316 in diagnosing lung cancer in patients with untreated lung cancer

Conditions: Lung Cancer

Summary: rationale: doctors can diagnose lung cancer by collecting mucus coughed up from the lungs and examining it under a microscope to look for cancer cells. breathing in ins316 may make it easier for patients to cough up mucus. purpose: randomized phase ii trial to study the effectiveness of ins316 in helping to diagnose lung cancer.

objectives: i. determine whether a cytological diagnosis of lung cancer can be obtained more frequently from sputum specimens following inhalation of ins316 compared to specimens obtained following placebo or compared to specimens spontaneously expectorated in patients with untreated lung cancer. ii. assess the relative sensitivity of sputum cytology in the diagnosis of lung malignancies in this patient population using these sputum collection regimens. iii. determine the quantity of macrophages in sputum of these patients using these techniques. iv. determine if the number of macrophages in sputum obtained by these methods is predictive of the likelihood of obtaining a positive diagnosis of lung cancer in these patients. v. determine the total amount of sputum expectorated from these patients using these techniques. outline: this is a randomized, double-blind, placebo-controlled, cross-over, multicenter study. patients are randomized to one of two arms, then cross-over to the other arm. arm i: patients receive ins316 by inhalation via a nebulizer. sputum is collected throughout the dosing and for 1 hour post dosing. arm ii: patients receive placebo in the same manner as ins136 in arm i. all patients receive both treatments. patients receive the first dose no more than 7 days after screening, and the second dose 3 to 10 days after the first dose. patients are followed 1 day after completion of the second treatment. the sputum samples are fixed and examined cytologically. projected accrual: approximately 100-130 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: histologically or cytologically proven primary lung cancer or presumptive diagnosis based on chest x-ray, ct scan, history, or symptoms no prior treatment patient characteristics: age: 18 and over performance status: not specified life expectancy: not specified hematopoietic: not specified hepatic: not specified renal: not specified pulmonary: fev1 at least 35% predicted other: not pregnant or nursing negative pregnancy test fertile patients must use effective contraception no other comorbid condition that would preclude study prior concurrent therapy: see disease characteristics at least 4 days since prior bronchoscopic examination or pulmonary fine needle aspiration biopsy at least 3 days since prior sputum induction no concurrent medication that would preclude study at least 30 days since prior investigational drugs (including ins316) or experimental therapy

Keywords: non-small cell lung cancer small cell lung cancer
the impact of continuous glucose monitoring use on sleep in parents of children with type 1 diabetes mellitus

Conditions: Type 1 Diabetes

Summary: the purpose of this prospective exploratory study is to compare sleep quality and sleep-wake patterns in parents of children with type 1 diabetes (t1d) before and several weeks after initiating using real-time continuous glucose monitoring (rt-cgm) of their children.

few weeks before scheduled initiation of rt-cgm use of a child with t1d, the 'dominant parent' (the main caregiver during the nighttime in the family) will obtain an informed consent. this will be done during a routine visit in the diabetes clinic. the participants will complete a sleep quality questionnaire (psqi) and instructions on care of the actigraph and how to keep complete the daily sleep diary will be given. the participants will be instructed to wear the actigraph for 7 consequences nights. four to eight weeks after initiation of rt-cgm use, the 'dominant parent' will be asked to wear the actigraph for 7 consequences nights and to complete the sleep quality questionnaire and the daily sleep diary.

Eligibility criteria:
inclusion criteria: * parents of children up to 16 years old with type 1 diabetes exclusion criteria: * either the child or parent had obstructive sleep apnea, narcolepsy, or restless legs syndrome.

Keywords: type 1 diabetes sleep quality parents
isolation of the spermatic cord in mesh inguinal hernia repair

Conditions: Inguinal Hernia

Summary: there are in excess of 1 million operations performed annually to repair inguinal hernias, mostly in the male population. unfortunately, some patients continue to suffer both groin or testicular pain for varying lengths of time postoperatively. this can lead to a severe degradation of the patient's lifestyle, work habits and sexual function. the origin of the pain is felt to be secondary to the inflammatory reaction caused by the mesh. this also involves the spermatic cord and its structures, leading to orchidinia and possibly azospermia.

in this prospective randomized trial, male patients with a primary symptomatic unilateral inguinal hernia will be admitted to the trial. all patients must be over 21 years of age. in order to avoid inguinal nerve entrapment or damage by mesh fixation sutures covidien parietene progrip mesh will be employed. this mesh does not require fixation. standard open inguinal hernia repair will take place with nerve preservation, as day surgery cases. in the randomized portion of the study, the mesh will be placed as usual along the posterior wall of the inguinal canal, however the inguinal ligament will be interposed between the mesh and the spermatic cord, thus isolating the cord from intimate contact with the mesh, and a reduction in postoperative inflammatory changes.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of a primary unilateral inguinal hernia exclusion criteria: * medically unfit for surgical repair

Keywords: inguinal hernia repair mesh groin pain testicular pain
cognitive-behavioural therapy (cbt) for insomnia via internet or telehealth

Conditions: Insomnia

Summary: cognitive-behavioural therapy (cbt) is an effective treatment for chronic insomnia, which is a prevalent and costly problem. this pilot study will compare the effectiveness of two brief (6 week) psychological interventions delivered to residents of rural manitoba using telehealth or an interactive internet-based platform. it is hypothesized that a) participants in the telehealth condition will report significantly greater improvements in sleep parameters(e.g., sleep efficiency, time awake in bed, sleep-onset latency),insomnia severity, and daytime fatigue than those in the internet condition and that b)participants in the telehealth condition will show better adherence to treatment and greater satisfaction with treatment than those in the internet condition.


Eligibility criteria:
inclusion criteria: * must be residents of rural manitoba (canada) * must meet research diagnostic criteria for insomnia * must have access to a computer and high-speed internet exclusion criteria: * comorbid conditions (medical and psychiatric) must be stable

Keywords: insomnia cognitive-behavioral therapy internet telehealth
study on the mechanism of neurodevelopment dysplasia of fetal brain caused by asns gene mutation

Conditions: Asparagine Synthetase Deficiency; Genetic Diseases, Inborn

Summary: the investigators propose to analyze a brain sample and/or peripheral blood by single cell rna seq from aborted embryos with asns mutation.

congenital microcephaly could cause by gene mutation. asparagine synthetase deficiency, which is caused by asns mutation, is a rare autosomal recessive neurometabolic disorder. it is characterized by severe developmental delay, congenital microcephaly, seizures. the investigators found a family with asns mutaion. the investigators propose to analyze a brain sample and/or peripheral blood by single cell rna seq from aborted embryos with asns mutation.

Eligibility criteria:
inclusion criteria: * mutation group: having asns gene mutation by dna exon sequencing. * control group: no asns gene mutation by dna exon sequencing. exclusion criteria: * mutation group: n/a. * control group: having other gene mutation which also effect neurodevelopment.

Keywords: asns, single cell rna seq, neurodevelopmental dysplasia,