Kornimate/medical-research-clean huggingface dataset:
exercise-stimulated muscle glucose uptake in upper body obesity

Conditions: Upper Body Obesity

Summary: the purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.


Eligibility criteria:
inclusion criteria: for the exercise studies of leg glucose uptake - "insulin sensitive" group: * sedentary, normal weight, premenopausal women. * sedentary, age-matched normal weight men. * weight stable for two (2) months prior to study. * willing to provide written, informed consent. * for the exercise studies of leg glucose uptake - "insulin resistant" group: for the exercise studies of leg glucose uptake - "insulin resistant" group: * upper body obese (ubo) premenopausal women. * age-matched upper body obese (ubo) men. * weight stable for two (2) months prior to study. * willing to provide written, informed consent. exclusion criteria: * age \ 55 years (premenopausal women and age-matched men). * use of glucose-lowering agents. * for female subjects: positive pregnancy test at the time of enrollment or study * history of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy. * active systemic illness or malignancy. * symptomatic macrovascular or microvascular disease.
sensory awareness program

Conditions: Anxiety

Summary: few alternatives to addictive medical treatment exists for persons with severe mental health problems (smhp) and anxiety, often connected to high risk of suicide. access to effective interventions that depart in individuals' needs to cope with anxiety in everyday life is crucial to provide and desperately warranted by service users. service users are often unaware of sensory needs, connected to anxiety outburst. the sensory awareness program (sap) is a group-based self-management intervention of 10 weeks developed to meet complex needs of regulating anxiety and related self-destructive behaviors. sap stems from theories on sensory modulation and is an approach to manage physiological arousal associated with anxiety through self-regulated sensory-based coping strategies. international research show that sensory modulation is effective both as a method to reduce anxiety and thus restraint in acute mental health services (mhs), and also to empower users. however, much research to date focus on using sensory strategies within wards. international research and pre-studies of testing the sap in outpatient mhs indicate that it is a promising self-management intervention to support everyday life. earlier studies further show that users' unawareness of sensory needs triggers anxiety, and that anxiety itself is the main contributing factor for disrupting everyday life. also, staff acknowledge sensory modulation but lack knowledge on whether programs such as sap is effective and possible to implement. the overall aim is to investigate the effectiveness of sap as compared to treatment as usual (tau) among 200 outpatients. the investigators hypothesize that sap will be more effective than tau in terms of reduced anxiety (primary outcome) at three months follow-up. secondary clinical and personal recovery outcomes post intervention and at three and six months follow up will also be targeted and assumed to be in favour of the sap group. the implementation process of the sap will also be explored.


Eligibility criteria:
inclusion criteria: * be assigned to a mhs * age over 18 * having smhp (including a diagnosis of mood disorder, anxiety disorder, eg ptsd, panic disorder etc, and/or psychotic disorder) * experience anxiety exclusion criteria: * acutely mentally unwell * cognitively impaired * non-swedish speaking
irradiation modulates the pharmacokinetics of anticancer drugs for head and neck cancer

Conditions: Head and Neck Cancer

Summary: the concurrent use of chemotherapy during radiation therapy (ccrt) is now the important treatment stratagem for locally advanced head and neck cancer or nasopharyngeal cancer (npc). for these cases, 5-fluorouracil (5-fu) and cisplatin (cddp) are the most commonly used agents of ccrt. it plays an important role to improve the treatment outcome and increases the opportunities for organ preservation. in the past, radiotherapy (rt) was solely used as a local treatment and its effect was estimated by local effect model. however, growing evidence shows that irradiation has direct dna damage-dependent effects as well as sending signals to neighboring cells. recently, the investigators reported that abdominal irradiation could significantly modulate the systemic pharmacokinetics of 5-fu at 0.5 gy, off-target area in clinical practice, and at 2 gy, the daily treatment dose for target treatment in an experimental rat model. additionally, the results from a clinical investigation showed that colorectal cancer patients with lower auc of 5-fu during adjuvant chemotherapy had lower disease-free survival. taken together, these lines of evidence support the importance and necessity to search for the mediators responsible for the unexpected effect of local rt on systemic pharmacokinetics of chemotherapeutic agents, such as 5-fu. in the present study, the investigators examined whether the phenomena and mechanism of rt-pk(pharmacokinetics) is a fact for different anticancer drugs and for different part in human.


Eligibility criteria:
inclusion criteria: * locally advanced head and neck, nasopharyngeal cancers, who prepares for concurrent chemoradiation therapy as definitive or adjuvant setting exclusion criteria: * previous cancer history；abnormal function of liver and kidney, immunol disease or hematologic disease

Keywords: phenomena and mechanism of rt-pk fact for different anticancer drugs different part in human
fenofibrate in type 2 diabetes

Conditions: Diabetes Mellitus, Type II

Summary: diabetic complications affecting the eyes, kidneys, and nerves are difficult to arrest once in progress. recent evidence that fenofibrate confers a robust yet unexpected benefit in diabetic retinopathy offers an important translational research opportunity. the investigator's global proteomic study will provide new clues as to how fenofibrate protects vulnerable tissues, and will spur discovery of targets for new therapeutic interventions.


Eligibility criteria:
inclusion criteria: * type 2 diabetes of at least one year's duration; stable glycemic control (no more than 1.0% change in hba1c in the previous six months, but no limit on hba1c) * triglycerides \>150 mg/dl (in the previous six months) exclusion criteria: * previous use of fenofibrate or other fibrates * pregnancy * active malignancy * recent cardiac event or congestive heart failure * active liver disease * significant renal impairment (serum creatinine \> 2mg/dl)
arthroscopic assisted distal radius fracture fixation

Conditions: Radius Fracture

Summary: distal radius fractures (drf) are among the most common orthopedic injuries, both in young adults and in elderly patients.(1,2,4،7 ) effective management of these fractures is crucial to restoring wrist function, ensuring stability, and minimizing complications. (2)traditional open reduction and internal fixation (orif) remains the cornerstone of treatment. (3)however, minimally invasive techniques are increasingly gaining attention for their ability to improve outcomes while reducing complications.(5, 8) wrist arthroscopy has emerged as a valuable tool in the management of drf. it allows for direct visualization of intra-articular fractures, assessment of associated soft tissue injuries, and precise reduction of fracture fragments. additionally, it facilitates the identification and management of concomitant injuries, such as triangular fibrocartilage complex (tfcc) tears or ligament injuries, which are frequently overlooked in traditional techniques. (6, 9 ،10) despite these advantages, the use of wrist arthroscopy in drf management remains underutilized in many regions. in assiut university hospital, there is a growing interest in incorporating advanced techniques, including wrist arthroscopy, into the management of orthopedic injuries. however, there is limited local data on the outcomes and feasibility of this approach in the treatment of drf. this case series aims to evaluate the clinical and functional outcomes of drf management using wrist arthroscopy, providing insight into its effectiveness, safety, and applicability in a tertiary care setting. by documenting the experiences and outcomes of patients treated with this innovative technique, this study seeks to contribute to the existing literature and guide the future adoption of arthroscopy-assisted methods in drf management in the region. -the aim of this study is to evaluate the clinical and functional outcomes of managing distal radius fractures assisted by wrist arthroscopy at assiut university hospital using mayo wrist score, with a focus on its effectiveness, safety, and feasibility in improving fracture reduction, identifying associated injuries, and enhancing patient recovery.


Eligibility criteria:
inclusion criteria: * recent distal radius fractures which occurred less than 14 day clssification 2r3b1,2r3b2,2r3b3,2r3c1 on ao classification with articular surface displacement or gap ≥ 2mm after reduction * patient aged from 18 to 60 years. * potential associated ligament injuries. exclusion criteria: * poly-traumatized patients or those with other fractures in the same upper limb. * open fractures or neurovascular deficit or medical fractures. * patient with severe complications that prevent clear visualization during arthroscopy. * patient with uncontrolled chronic diseases, especially uncontrolled dm or htn
mind-body approach and gut microbiota in osteoarthritis

Conditions: Osteoarthritis

Summary: this exploratory study is to compares mechanisms of mind-body exercise with wellness education program on gut microbiota for osteoarthritis as a basis for a future large-scale trial.

this exploratory study is to determine the effect of mind-body exercise on gut microbiota in patients with osteoarthritis. we will randomize 80 eligible individuals who meet the american college of rheumatology criteria for osteoarthritis into tai chi or wellness education interventions for 12 weeks. using 16s rrna amplicon sequencing of fecal dna samples we will compare the changes in gut microbiota profiles using 16s rrna gene amplicon sequencing, and quantity of streptococcus species using quantitative pcr, as well as their association with clinical outcomes. this exploratory study will guide the development of theoretically informed, effective treatment for a high-risk population further enlighten us about the pathogenesis of metabolic osteoarthritis pain.this proposal will provide crucial preliminary knowledge of the mechanism underlying tai chi mind-body therapy for metabolic osteoarthritis.

Eligibility criteria:
inclusion criteria: * age ≥ 55 years * fulfills the american college of rheumatology criteria for symptomatic oa * baseline (month 0) womac pain subscale score ≥ 40 exclusion criteria: * dementia, neurological disease, cancer, cardiovascular disease, renal disease, liver disease, or other serious medical conditions limiting ability to participate in the programs. * factors known or likely to impact the intestinal microbiota or known to be associated with microbial translocation: antibiotic or probiotic use within the previous 4 weeks, gastrointestinal morbidity (irritable bowel syndrome, inflammatory bowel disease, history of gastrointestinal cancer or surgical resection, or acute, severe gastrointestinal symptoms requiring medical attention), opportunistic infection, and evidence of hepatitis b or c virus infection
flourishing app: evaluation of the effectiveness of a well-being application for mobile devices

Conditions: Emotional Stress

Summary: this protocol proposes a well-being program, delivered through an application for mobile devices, based on meditation and positive psychology principles such as human development, the improvement of virtues, quality of life and well-being. the investigators hypothesize that this program offered in mobile application may promote well-being and reduce stress related problems in the participants. objectives: to evaluate the effectiveness of a well-being program delivered through an application for mobile devices in a sample of employees who work in a company (natura inovação/cosméticos) and in a hospital (hospital israelita albert einstein). methods: two hundred and fifty employees from natura inovação/cosméticos and 250 employees from hospital israelita albert einstein will be recruited. the participants will be randomized in two groups of 125 participants each one, half of them in the control group (gc) and the other half to the intervention group (gi), by institution.

introduction: stress related disorders may result in absenteeism and less productivity in companies. this protocol proposes a well-being program, delivered through an application for mobile devices, based on meditation and positive psychology principles such as human development, the improvement of virtues, quality of life and well-being. in the modern world not all people are willing to attend classroom training for several reasons. in this sense, the investigators hypothesize that this program offered in mobile application may promote well-being and reduce stress related problems in the participants. objectives: to evaluate the effectiveness of a well-being program delivered through an application for mobile devices in a sample of employees who work in a company (natura inovação/cosméticos) and in a hospital (hospital israelita albert einstein). methods: two hundred and fifty employees from natura inovação/cosméticos and 250 employees from hospital israelita albert einstein will be recruited. the participants will be randomized in two groups of 125 participants each one, half of them in the control group (gc) and the other half to the intervention group (gi), by institution. the gi will participate in the flourishing app program, for eight weeks, while the gc will have access to a control app. then, after the evaluations, the gc will receive the intervention (flourishing app program), while the first group will not receive any intervention. questions will be applied to evaluate the levels of stress and well-being of participants before and after the program and before and after each training period.

Eligibility criteria:
inclusion criteria: * female aging from 18 to 60 * complete higher education * employees from natura inovação/cosméticos and from hospital israelita albert einstein exclusion criteria: * none

Keywords: stress well-being positive psychology
clinical utility of the addition of a snp-based nipt zygosity determination in twin pregnancy management.

Conditions: Twin to Twin Transfusion Syndrome; Pregnancy Complications; Multiple Gestation; Maternal Care

Summary: the ztwins registry study is an observational, prospective, multi-center study observing women carrying a twin pregnancy who receive snp-based non-invasive prenatal screening and zygosity assessment as part of their medical care.

this observational data collection study will include subjects with ultrasound-confirmed twin pregnancy and planned nips zygosity assessment as a part of their clinical care. initial chorionicity assessment and, when available, planned twin pregnancy management (e.g., frequency of prenatal ultrasounds, maternal fetal medicine (mfm) referral etc) will be recorded in the study database. following zygosity results being returned through clinical care nips, updated chorionicity \& amnionicity will again be recorded in the study database. other clinical data in the medical record as part of clinical care, including monochorionic twin pregnancy complications (ttts, ftc referral, etc), placenta pathology findings, and delivery and neonatal outcomes will also be recorded in the study database. there will be no study blood sample collection or other study procedures performed as part of this study.

Eligibility criteria:
inclusion criteria: * women with an ultrasound confirmation of twin pregnancy exclusion criteria: * singleton or non-twin multiple pregnancy
gastric ultrasound for preoperative assessment of gastric content in diabetic patients

Conditions: Aspiration Pneumonia; Gastric Volume

Summary: asa fasting guidelines are only applicable to healthy elective surgery patients. measuring gastric volume now is not easy, and scintigraphy has remained the gold standard technique for many years. this prospective observational study aim to explore the gastric emptying of type 2 diabetic patients.

asa fasting guidelines are only applicable to healthy elective surgery patients. measuring gastric volume now is not easy, and scintigraphy has remained the gold standard technique for many years. ultrasound has progressively emerged as a useful substitute due to its reduced cost and ease of performance. using gastric ultrasound measure gastric antrum cross-sectional area to determine whether patients are empty stomach, help anesthesiologists in preoperative evaluation of diabetic patients with the risk of aspiration, so as to guide the anesthesiologist take effective interventions, this prospective observational study aim to explore the gastric emptying of type 2 diabetic patients.

Eligibility criteria:
inclusion criteria: 1. ages \>18 years old 2. diabetes (i or ii) 3. following american society of anesthesiologists (asa) fasting guidelines before surgery 4. undergoing general anesthesia exclusion criteria: 1. pregnant 2. gastric intestinal tract (git) diseases or surgeries affect gastric emptying 3. diagnosed with liver dysfunction or renal insufficiency 4. patients who are unable to cooperate or understand the process
acute sleep deprivation on whole-body heat exchange during exercise-heat stress in young and older men

Conditions: Thermoregulation; Sleep Disturbance; Heat Exchange; Aging; Exercise

Summary: sleep deprivation has long been thought to modulate thermoregulatory function. seminal work on sleep deprivation and thermoregulation has demonstrated that sleep-deprived individuals experience greater elevations in core temperature during exercise-heat stress due to reductions in the activation of local heat loss responses of cutaneous vasodilation and sweating. however, it remains unclear 1) if reductions in local heat loss responses would compromise whole-body heat loss (evaporative + dry heat exchange) and 2) if differences exist, are they dependent on the heat load generated by exercise (increases in metabolic rate augments the rate that heat must be dissipated by the body). further, much of the understanding of the effects of sleep deprivation on thermoregulation has been limited to assessments in young adults. studies show that aging is associated with reduction in cutaneous vasodilation and sweating that compromise whole-body heat loss exacerbating body heat storage during moderate- and especially more vigorous-intensity exercise in the heat. however, it remains unclear if sleep deprivation may worsen this response in older adults. the purpose of this study is therefore to evaluate the effects of sleep-deprivation on whole-body total heat loss during light, moderate, and vigorous exercise-heat stress and to assess if aging may mediate this response. to achieve this objective, direct calorimetry will be employed to measure whole-body total heat loss in young (18-30 years) and older (50-65 years) men during exercise at increasing, fixed rates of metabolic heat production of 150 (light), 200 (moderate), and 250 w/m2 (vigorous) in dry heat (40°c, \~15% relative humidity) with and without 24 hours of sleep deprivation.


Eligibility criteria:
inclusion criteria: * healthy young (18-30 years) and older males (50-65 years) * non-smoking * english or french speaking * ability to provide informed consent exclusion criteria: * presence of chronic diseases (e.g., hypertension, diabetes) * acute illness (e.g., flu, covid-19) * physical restriction limiting physical activity (e.g., severe arthritis, etc.) * use of medication judged by the patient or investigators to make participation in this study inadvisable * engaged in regular endurance training

Keywords: heat stress sleep aging heat dissipation physical activity
adenovirus infection in children with autoimmune hepatitis

Conditions: Observational

Summary: adenoviruses have been linked to severe hepatitis in children. they are non-enveloped, icosahedral viruses of medium size (90-100 nm) (5). adenoviruses usually infect the respiratory tract, eyes, urinary tract, intestines, and central nervous system (6). these diseases are

hepatitis is an inflammatory reaction of the liver that lead to a spectrum of health problems (1). hepatitis results from a variety of causes, both infectious and non-infectious. infectious agents include viruses and parasites. non-infectious causes include drugs and toxic agents (2). viral hepatitis remains an important challenge to human health, making it a leading cause of death globally. the absolute burden of viral hepatitis is increasing gradually (3). the most common types of viral hepatitis are hepatitis a, b, and c. the other types are hepatitis d and e, which are less frequent (2). epstein-barr virus (ebv) and cytomegalovirus (cmv) infections are common and are associated with liver manifestations (4). adenoviruses have been linked to severe hepatitis in children. they are non-enveloped, icosahedral viruses of medium size (90-100 nm) (5). adenoviruses usually infect the respiratory tract, eyes, urinary tract, intestines, and central nervous system (6). these diseases are generally self-limiting, but severe infections can occur in immunocompromised hosts (7). children are more susceptible to hadvs infection because their immune systems are less developed. hadvs cause a range of symptoms, including colds, vomiting, diarrhea, and sometimes pneumonia, but rarely hepatitis in immunocompromised patients (8) in april 2022, the who has reported severe acute hepatitis outbreaks among children from 11 countries across europe and america, which have induced great public concern, hadv is presumed to be a possible etiology of this outbreak (9). the diagnostic methods for adenovirus include antigen detection, polymerase chain reaction (pcr), virus isolation, and serology (10).

Eligibility criteria:
inclusion criteria: - all children who are presented with symptoms suggestive of acute hepatitis like clinical jaundice, in the form of yellowish discoloration on sclera, fever, abdominal pain, diarrhea and raised liver enzymes between age group 2 years and 16 years. exclusion criteria: * -all patients under 2 years old and above 16 years. * history of drug intake which may affect liver functions