Kornimate/medical-research-clean huggingface dataset:
pre-operative chemotherapy versus concurrent chemoradiotherapy in locally advanced non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: this phase ii trial is to compare neoadjuvant chemotherapy with concurrent chemoradiotherapy in patients with locally advanced non-small cell lung cancer (nsclc) to address optimal induction strategy.

management of locally advanced non-small cell lung cancer (nsclc) remains a challenge. both local relapses and distant metastases are frequent, with 5-year survival of 3-17% for inoperable disease. staging has historically subdivided stage iii disease into clinical stage iiia, thought to be potentially amenable to surgery, and stage iiib, treated by defi nitive radiotherapy or radiochemotherapy. this phase ii trial is to compare neoadjuvant chemotherapy with concurrent chemoradiotherapy in patients with locally advanced nsclc to address optimal induction strategy.

Eligibility criteria:
inclusion criteria: * histopathologic diagnosis of non small-cell lung cancer * clinical stage iiia and/or iiib without pleural effusion * ecog functional status 0 or 1 * no renal function alteration (gfr \>50%) * no hepatic function alteration (alt and ast less than 2 times its normal value) * leucocytes more than 2,000/mcl * hemoglobin more than 10mg/dl * platelets more than 100,000/mcl exclusion criteria: * active uncontrolled infection. * serious concomitant disorders that would compromise the safety of patient or compromise the patient's ability to tolerate therapy. * mi within preceding 6 months or symptomatic heart disease including unstable angina, congestive heart failure, or uncontrolled arrhythmia. * significant neurological or mental disorder. * second primary malignancy. * pregnant or nursing.

Keywords: neoadjuvant chemotherapy neoadjuvant chemoradiotherapy
laughter therapy effects on mood, stress and self-efficacy in people with neurological diseases.

Conditions: Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Brain Injury; Huntington's Disease; Multiple Sclerosis; Parkinson's Disease; Stroke; Spinal Cord Injury

Summary: this is a prospective investigation of the effects of laughter therapy (lt) on perceived stress, self-efficacy, mood and other wellness measures in people with the following neurological conditions: alzheimer's disease, amyotrophic lateral sclerosis, brain injury, huntington's disease, multiple sclerosis, parkinson's disease, post-stroke, spinal cord injury.

laughter therapy (lt) has potential benefits in treating illness. it combines laughter with breathing and body exercises to stimulate laughter, both real and artificial, in a group setting. laughter therapy may help treating illness by strengthening breathing muscles, improving mood, and providing pain and stress relief. evergreenhealth has presented laughter therapy classes to patients with parkinson's disease and multiple sclerosis and other neurological conditions. the therapy will be led by a certified laughter therapist and mental health professional.

Eligibility criteria:
inclusion criteria: * diagnosis based on medical record review of one of the following neurological diseases: alzheimer's disease, amyotrophic lateral sclerosis, brain injury, huntington's disease, multiple sclerosis, parkinson's disease, post-stroke, spinal cord injury. * medically stable for at least 2 months. * not participating in laughter therapy for 30 days prior to screening. exclusion criteria: * females who are pregnant * any unstable medical condition * severe cognitive deficits that would interfere with participation (e.g. unable to follow commands). * severe abdominal pain, chest pain or back pain. * abdominal, chest or back surgery within 90 days. * psychosis or severe mental illness. * untreated hernia. * persistent cough. * advanced hemorrhoids. * epilepsy. * uncontrolled hypertension - sbp \>170 or dbp \>105.
the comparison of incidence and risk factors of postoperative delirium in elderly patients after lower extremity surgery

Conditions: Postoperative Delirium

Summary: the aim of this study is to compare the risk factors and the incidence of delirium following orthopedic surgery under the general or regional anesthesia in elderly patients.

one hundred twenty elderly patients aged ≥65 years scheduled for total hip or knee arthroplasty and femur fracture surgery were enrolled into the study. patients were allocated into two groups to receive regional anesthesia (group r, n=50) or general anesthesia (group g, n=70). hemodynamic and blood parameters, potential risk factors of delirium including age, sex, duration of surgery, the type of anesthesia, coexisting disease, smoking and amount of drug used delirium tests (cam and drs-r-98), hospital stay and costs were recorded for all patients.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists physical status i-iii, * 120 patients aged ≥65 years scheduled for total hip or knee arthroplasty and femur fracture surgery exclusion criteria: * exclusion criteria were patient refusal, abuse of alcohol and/or drugs * hypersensitivity to local anesthetics * vertebral abnormality * previous lumbar vertebra surgery * coagulation disorder * infection (systemic or local) * cerebrovascular disease * neurosurgery * vascular surgery * frequent use of analgesic drug * ≥5 drugs per day and psychiatric medication

Keywords: delirium regional anesthesia general anesthesia
optimizing the management of postpartum urinary retention

Conditions: Urinary Retention

Summary: a study aimed at characterizing the comparing duration of catheterization for treatment of postpartum urinary retention (pur) and characterizing short and long-term pelvic floor symptoms in women who have pur.

the purpose of the study is to compare clinical outcomes of women with bladder distension injuries due to postpartum urinary retention (pur) who have varying duration of catheterization for initial treatment of postpartum urinary retention. hypotheses 1. longer duration of therapeutic catheterization will be associated with resolution of postpartum voiding dysfunction in women who sustain severe bladder distension injuries due to postpartum urinary retention. definition of resolution of postpartum voiding dysfunction: a. a post void residual volume of less than half of initial instilled volume on the first retrograde voiding trial, and b. no need for re-treatment for urinary retention within 1 week 2. the incidence of postpartum urinary retention (pur) will vary by route of delivery, with operative vaginal delivery having the highest incidence. 3. risk factors for pur will be related to intrapartum and delivery conditions

Eligibility criteria:
inclusion criteria: 1. age greater than or equal to 18. 2. vaginal or cesarean delivery at term (37 weeks gestational age or later) of live-born infants. 3. english or spanish speaking and reading. exclusion criteria: 1. adults unable to consent. 2. women under the age of 18. 3. women who are currently pregnant (all women in the study will have already delivered). 4. prisoners or detained individuals. 5. women who chronically use a urinary catheter for another medical condition. 6. women with a neurological disease with bladder manifestations (examples: cerebrovascular accidents, multiple sclerosis, parkinson disease, cerebral palsy). 7. women with preeclampsia requiring magnesium treatment for seizure prevention. 8. women with prior pur 9. women on anticholinergic medications. 10. women who are actively being treated for a uti.
effect of proprioceptive neuromuscular facilitation on blood pressure

Conditions: Hypertension

Summary: to determine the effect of proprioceptive neuromuscular facilitation exercise on blood pressure in patient with mild to moderate hypertension.both genders will be included.patients aged between 40 and 60 years with mild and moderate hypertension.systolic blood pressure 130-160 mmhg or diastolic blood pressure 80-100 mmhg. sphygmomanometer and euroqol five-dimensional instrument would be used for the 'pre' \& 'post' assessment.

there is a belief that proprioceptive neuromuscular facilitation exercises cause cardiac overload as blood pressure in immediately influenced by exercise but pereira concluded in his research that proprioceptive neuromuscular facilitation exercises with minimum repetitions are safe for hypertensive or cardiovascular patients because in his study there is no increase in blood pressure in older women after performing three different types of pnf exercises. pereira discovered that rhythmic initiation , dynamic reversals , and combination of isotonic techniques did not raise blood pressure levels, thus it is recommended to use up to five repeats of repetition maximum . one study observed at the effects of passive and modified proprioceptive neuromuscular facilitation (pnf)stretching techniques on acute systolic and diastolic blood pressure responses. all pnf treatments were beneficial in increasing range of motion, as we all know. pnf improves range of motion while avoiding an increase in systolic blood pressure in one or two trials, but increases systolic blood pressure in a third trial. blood pressure rises by 40% with conventional exercise programmers and because pnf involves near-maximal resistance,researchers anticipated a considerable rise in blood pressure during pnf execution. it was discovered that elderly subjects could not readily execute more than five to seven repetitions of pnf exercises, which has also been shown by others. due to the low repetition number of each movement pattern, the results showed that pnf did not induce a high enough workload to increase blood pressure in the elderly.

Eligibility criteria:
inclusion criteria: * both genders will be included. * patients aged between 40 and 60 years with mild and moderate hypertension. * systolic blood pressure 130-160 mmhg or diastolic blood pressure 80-100 mmhg. * mild and moderate hypertension with diabetes exclusion criteria: * severe hypertensive patients. * patient on smoking * patient with severe complications and comorbidities. * not willing to give consent/ data

Keywords: proprioceptive neuromuscular facilitations ankle brachial index diabetes
a non-interventional, post-authorisation safety study of patients treated with efgartigimod alfa

Conditions: Myasthenia Gravis

Summary: this is a non-interventional, prospective, post authorization safety study. patients with gmg who are expected to start treatment with efgartigimod at enrolment or are within their first cycle of efgartigimod at enrolment will be eligible to enroll into the efgartigimod cohort. patients with gmg who have not been exposed to efgartigimod and for whom it is not planned to start treatment with efgartigimod at enrolment will be eligible to enroll into the non-efgartigimod cohort.


Eligibility criteria:
inclusion criteria: * patients diagnosed with gmg who are expected to start commercial efgartigimod at enrolment or who are within their first cycle of efgartigimod at enrolment or patients diagnosed with gmg who have not been exposed to efgartigimod and for whom it is not planned to start treatment with efgartigimod at enrolment * have provided appropriate written informed consent exclusion criteria: * none
magnesium sulphate neuroprotective strategies for preterm deliveries

Conditions: Premature Birth; NEUROPROTECTION; MAGNESIUM SULPHATE; Cerebral Palsy; Neonatal Death

Summary: a cochrane systematic review has confirmed that fetal exposure to magnesium sulphate given before preterm birth has a neuroprotective role. this review also showed a significant reduction in the rate of gross motor dysfunction in early childhood. early preterm birth (\< 34+0 weeks) and very low birthweight (\< 1,500 g) are the principal risk factors for cerebral palsy. multiple pregnancy accounts for over 10% of preterm births and has a higher incidence of cerebral palsy than singleton pregnancy (twins have 7 times and triplets 47 times the risk of cerebral palsy compared with singletons).

many of these patients come or get diagnosed as eminent preterm delivery very soon before the real delivery happens and are not able to complete the recommended therapy of loading and maintenance strategy for at least complete 4 hours before delivery. till now, there is a gap and lack of knowledge regarding the value of loading dose only as sufficient and effective strategy for neuroprotection compared to full therapy, which needs more health costs, longer monitoring and carries more risk for the patients.

Eligibility criteria:
inclusion criteria: 1. women at risk of preterm birth who are between 24+0 and 33+6 weeks of gestation. 2. when early preterm birth is planned or expected within 24 h, regardless of: * plurality or parity * reason for the risks of preterm birth * anticipated mode of birth * whether antenatal corticosteroids have been given or not exclusion criteria: * women with known hypersensitivity to magnesium * caution regarding dosage for patients with renal impairment * preterm delivery after 34 weeks

Keywords: cerebral palsy preterm birth neuroprotection neonatal death magnesium sulphate
treatment outcomes of temporomandibular disorders using stabilization splint supported by the t-scan system

Conditions: Temporomandibular Disorders (TMD)

Summary: this study aims to evaluate the treatment outcomes of temporomandibular disorders (tmd) using stabilization splints (ss) supported by the t-scan system at hanoi medical university hospital. thirty-six patients diagnosed with tmd based on the diagnostic criteria for temporomandibular disorders (dc/tmd) received customized stabilization splints. the t-scan system was used to optimize occlusal adjustments by providing real-time digital recordings of occlusal force distribution. clinical outcomes, including pain intensity (measured by visual analog scale - vas), maximum comfortable mouth opening (mco), occlusal time (ot), and disocclusion time (dt), were assessed at baseline, 1 month, and 3 months after treatment. the study investigates the effectiveness of t-scan-assisted occlusal adjustments in improving clinical symptoms and enhancing jaw function in patients with tmd.

this clinical study evaluates the therapeutic effectiveness of stabilization splints (ss) supported by digital occlusal analysis using the t-scan system in patients with temporomandibular disorders (tmd). thirty-six participants diagnosed with tmd according to the dc/tmd criteria were enrolled and treated at hanoi medical university hospital. custom-fabricated michigan-type stabilization splints were provided to all participants. occlusal adjustments were initially performed using articulating paper and then refined with the t-scan system, which measures occlusal timing and force distribution in real-time. the primary focus was on improving clinical symptoms such as pain reduction and jaw mobility enhancement. pain intensity was assessed with the visual analog scale (vas), and maximum comfortable mouth opening (mco) was recorded. occlusal time (ot) and disocclusion time (dt) were evaluated using the t-scan system. patients were followed up at 1 and 3 months post-treatment to monitor changes. the study explores the supportive role of digital occlusal adjustment in the conservative management of tmd and highlights the potential of the t-scan system to enhance the precision of splint therapy without direct modification of the natural dentition.

Eligibility criteria:
inclusion criteria: * diagnosed with temporomandibular disorders (tmd) based on the diagnostic criteria for temporomandibular disorders (dc/tmd). * willing and able to wear a stabilization splint as instructed. * provided written informed consent. exclusion criteria: * presence of systemic diseases (e.g., rheumatoid arthritis, fibromyalgia). * unstable general health condition. * psychological disorders that could interfere with compliance. * ongoing use of other treatments for tmd. * history of maxillofacial surgery within the past 6 months.

Keywords: temporomandibular disorders stabilization splints t-scan system
intermittent exotropia in egyptian population

Conditions: Exotropia

Summary: strabismus is one of the most frequent ocular problems among developmentally normal children. the prevalence of strabismus varies among different regions, ranging from 0.06% in japan to 5.65% in china. exotropia is reported to be the most prevalent type of deviation in many of these studies. about 48-92% of the exotropic patients have intermittent exotropia (ixt). jenkins reported that the prevalence of exodeviation was higher in countries near the equator. its prevalence is also higher in subequatorial africa, the middle east, and east asia (where there is plenty of sunshine) in comparison to the usa and central europe. intermittent exotropia is a disorder of binocular eye movement control, where one eye intermittently turns outward. the outward deviation is greatest and likely occurs at far distances viewing, when the oculomotor convergence effort is weakest, and occurs frequently when the patient is under stress, tired, ill, or in particular test situations. x(t) can also occur at near as convergence insufficiency.


Eligibility criteria:
inclusion criteria: * patients diagnosed with 8 prism diopters or more exodeviation at distant or near fixation, regardless of age or fusion control (including exophora, intermittent exotropia, and constant exotropia). exclusion criteria: * patients with congenital ocular anomalies or ocular mayopathies. patients with limitation of ocular motility resulting in strabismus, including neurologic or paralytic disorders, previous ocular surgical history, including strabismus and visually affecting surgeries, or any conditions affecting the central visual acuity, including anterior segment abnormality, cataracts, retinal diseases, or blepharoptosis (ocular sensory disorders), were excluded. when a patient was suspected to visit multiple institutions
study of skin balancing gel cream safety and influence of skin microbiome on acne prone skin

Conditions: Skin Microboime; Acne

Summary: the purpose of this study is to assess the safety of the skin balancing gel cream and examine the effects it has on the skin microbiome of individuals with non-cystic acne prone skin.

acne, a chronic inflammatory condition, is estimated to affect greater than 85% of the population at some point. it is considered a common skin condition characterized by pimples and occurs when follicles are clogged leading to the formation of acne lesions. in this study, we want to evaluate the impact the skin balancing gel cream has on the skin microbiome on individuals who have mild to moderate non-cystic acne. we will be assessing the changes it has on specific microbiota (cutibacterium acnes for example) and whether it is tolerated well on acne prone skin.

Eligibility criteria:
inclusion criteria: * males and females between the ages of 18 years of age until 35 years of age * males must be willing to shave facial hair * the presence of mild to moderate non-cystic acne based on investigator global assessment exclusion criteria: * individuals who are pregnant or breastfeeding. * prisoners. * adults unable to consent. * the presence of severe acne or cysts as noted by the investigator. * those who are unwilling to discontinue topical antibiotics, topical salicylic acid containing products and topical benzoyl peroxide containing products for two weeks to meet the washout criteria prior to enrolling. * those who are unwilling to discontinue all facial topical products except the cleanser and the product provided in the study. * individuals who have been on an oral antibiotic for acne within the previous 1 month. * individuals who have changed any of their hormonal based contraception within 3. months prior to joining the study. * current tobacco smoker or a tobacco smoking history of greater than 10 pack-years.

Keywords: skin microbiome
metabolic alternation and clinicohematological characteristic in chronic phase cml in patient treated with tki

Conditions: CML, Chronic Phase

Summary: metabolic alternation and clinicohematological characteristic in chronic phase cml in patient treated with tki

chronic myeloid leukemia (cml), a clonal hematopoietic stem cell malignancy, is characterized by unique translocation leading to the formation of the philadelphia chromo- some.because of the specific genotype knowledge, tyrosine kinase inhibitors have been used in cml and have significantly improved the prognosis of patients with cml, especially n high-income countries like the united states.notably, the 5-year survival rates increased from 40% to 90%. so, cml is increasingly seen as a chronic instead of a potentially fatal disease. obesity is increasingly prevalent worldwide and is considered o be an important risk factor for adverse outcomes in many cancers. obesity is well-known for being associated with metabolic abnormalities like hyperglycemia, hypertension, or dyslipidemia.the metabolic abnormalities and obesity- induced systemic chronic inflammation contribute to tumorigenesis and progression. obesity alone may not reflect the actual metabolic health state, and it appears to be more accurate to reclassify patients based on the combination of body mass index (bmi) and metabolic status to further determine the relationship between obesity itself or the combination of metabolic status and prognosis of patients with cml. triglyceride-to-high-density lipoprotein cholesterol ratio (tg/hdl-c) has been proposed as a reliable and simple alternative to assess atherogenic index, insulin resistance, and dyslipidemia.\[8\] furthermore, positive relationships between the tg/hdl-c ratio and various clinical features of many cancers, such as tumor stage and tumor type, have been reported in previous studies.\[9\] these findings warrant further studies to explore tg/ hdl-c ratio with respect to tki administration in cml and as a factor associated with side effects, and potentially, to assess its role in prognosis.

Eligibility criteria:
inclusion criteria: * patient newly diagnosed with cml and received tki exclusion criteria: * patient previously diagnosed cml and started treatment or in post treatment follow up