Kornimate/medical-research-clean huggingface dataset:
b7.1/il-2 leukaemia cell vaccine for non-transplant aml rfusin2-aml2 (ntx)

Conditions: Leukemia, Myeloid, Acute; Myelodysplastic Syndromes

Summary: the study will be an open label, single arm, phase i study intended to identify the safety and tolerability of "aml cell vaccine" given to eligible mds raeb-2 and aml patients who have achieved a best response of complete remission or partial remission following their first or second course of standard induction chemotherapy.


Eligibility criteria:
key inclusion criteria: * diagnosis of mds raeb-2 or primary (de novo) or secondary aml defined according to the who classification either as a new diagnosis or as a relapse. * patients for whom the optimal therapy in cr1 would be to undergo allogeneic bone marrow transplantation, but for whom this procedure is either not recommended (e.g. due to comorbidities) or not available (e.g. lack of a suitable donor). key exclusion criteria: * patients with mds raeb-2 or aml and favourable prognostic profile (good risk cytogenetics: t(15;17)(q22;q12\~21), inv16(p13q22)/t(16;16)(p13;q22), t(8;21)(q22;q22) or cytogenetically normal aml with npm1 mutation and absence of flt-3 itd). * patients unsuitable for standard induction chemotherapy. * patients who have previously undergone or will be able to undergo allogeneic transplantation. * patients who have had previous or current treatment with any form of investigational immunotherapy.
development of treatment algorithm for eradication of helicobacter pylori based on antibiotic susceptibility test

Conditions: Helicobacter Pylori Infection

Summary: helicobacter pylori eradication (h. pylori) rates with clarithromycin-based triple therapy are declining, and an alternative strategy is needed urgently. the investigators sought to compare the efficacy of pretreatment antimicrobial susceptibility-guided vs. clarithromycin-based triple therapy vs. concomitant therapy for h. pylori eradication in a region with high rates of multiple drug resistance.


Eligibility criteria:
inclusion criteria: 1. positive results of rapid urease test exclusion criteria: 1. liver cirrhosis, 2. chronic kidney disease, 3. bleeding tendency, 4. pregnant, 5. allergy to antibiotics
comparison of reposition sense in scoliosis and healthy adolescents

Conditions: Scoliosis; Adolescence; Healthy; Proprioception

Summary: the aim of the study is to compare the spine joint reposition sense in adolescent idiopathic scoliosis and healthy adolescents and to investigate whether there is a difference.

considering the role of proprioception during activities of daily living and exercises, it is important for clinicians and researchers to determine the joint position senses of adolescents with scoliosis and to compare them with their healthy peers in planning appropriate treatment programs. in the light of this information, the aim of the study is to compare the spine joint reposition sense in adolescent idiopathic scoliosis and healthy adolescents and to investigate whether there is a difference. patients who were diagnosed with adolescent idiopathic scoliosis (ais) in the department of orthopedics and traumatology of istanbul university and who were referred to the department of physiotherapy and rehabilitation of the faculty of health sciences of istanbul university-cerrahpaşa and biruni university and their healthy peers will be included in the study.

Eligibility criteria:
inclusion criteria: * being between the ages of 10 and 19 years * having a cobb angle of 10-40 degrees measured on the anteroposterior radiograph or a healthy spine alignment (forward bend test \< 5⁰ (negative) and flexicurve kyphosis index ≤13) * no previous conservative approach to scoliosis * volunteer to participate in the study exclusion criteria: * concomitant mental problem, rheumatological, neuromuscular, cardiovascular, pulmonary history * any orthopedic disability or severe pain that would preclude evaluations * musculoskeletal injury related to the spine in the last 3 months * having had spine surgery * presence of tumor in the spine * loss of vision and/or hearing/presence of vestibular problems

Keywords: scoliosis proprioception spine
trans-nasal maxillary multi-sinus balloon dilation study

Conditions: Sinusitis

Summary: the purpose of this study is to show clinically meaningful improvement in symptom severity after transnasal balloon dilation of the maxillary sinus outflow tract with or without balloon dilation of the frontal or sphenoid sinuses.

this is a prospective, non-randomized, single arm, post-approval study conducted under a common protocol designed to evaluate outcomes following trans-nasal balloon dilation of the maxillary sinus outflow tract with or without concurrent balloon dilation of the frontal or sphenoid sinuses and without any concomitant conventional sinus surgery (ie, uncinectomy, complete or partial ethmoidectomy).

Eligibility criteria:
inclusion criteria: 1. be at least age 18 years old or older. 2. be a candidate for transnasal balloon dilation of the maxillary sinus(es) with or without balloon dilation of the frontal or sphenoid sinus(es) using xpress consistent with the device's indication for use. 3. have a sinus ct scan within 12 months of the procedure date. 4. be able and willing to provide consent. 5. be willing to comply with the protocol requirements. exclusion criteria: 1. have any prior maxillary sinus surgery (eg, antrostomy, uncinectomy). 2. require any concomitant endoscopic sinus surgery (ess) or nasal surgery (exception: turbinate reduction) at the time of the study procedure. 3. have any nasal surgery (eg, septoplasty) or nonmaxillary sinus surgery (eg, frontal sinusotomy, sphenoidotomy, full/partial ethmoidectomy) performed within 3 months prior to enrollment. 4. have presence of features consistent with sinus fungal disease. 5. be allergic to nickel or barium sulfate. 6. be currently participating in any other drug or device clinical studies excluding postapproval or marketing registry studies.

Keywords: sinusitis sinus balloon dilation patients
vitamin d in treating patients with prostate cancer

Conditions: Prostate Cancer

Summary: rationale: vitamin d may be effective in treating patients with prostate cancer. purpose: this randomized phase ii trial is studying how well 4 different doses of vitamin d works in treating patients with prostate cancer.

objectives: primary * to examine the pattern of response of serum 25(oh) d3 levels following cholecalciferol (vitamin d3) supplementation at four different oral doses in patients with prostate cancer. secondary * to examine the pattern of response of parathormone (pth) following vitamin d3 supplementation in these patients. * to assess the toxicity of vitamin d3 supplementation in men with prostate cancer. tertiary * to track occurrence of infections, deep vein thrombosis, vascular events, and falls in these patients. outline: patients are randomized to 1 of 4 treatment arms. * arm i: patients receive 4,000 iu of oral cholecalciferol (vitamin d3) once daily. * arm ii: patients receive 6,000 iu of vitamin d3 once daily. * arm iii: patients receive 8,000 iu of vitamin d3 once daily. * arm iv: patients receive 10,000 iu of vitamin d3 once daily. treatment in all arms continues for 6 months in the absence of disease progression or unacceptable toxicity.

Eligibility criteria:
disease characteristics: * histologically confirmed adenocarcinoma of the prostate * 25(oh) d3 level \< 80 ng/ml patient characteristics: inclusion criteria: * ecog performance status 0-2 * creatinine ≤ 2.0 mg/dl * corrected serum calcium ≤ 10.5 mg/dl exclusion criteria: * history of malabsorption syndrome (e.g., pancreatic insufficiency, celiac disease, or tropical sprue) * hypersensitivity to cholecalciferol or one of its components prior concurrent therapy: * no other concurrent vitamin d supplementation

Keywords: adenocarcinoma of the prostate recurrent prostate cancer stage i prostate cancer stage ii prostate cancer stage iii prostate cancer stage iv prostate cancer
fenofibrate therapy in pathological unconjugated hyperbilirubinemia in full term infants

Conditions: Neonatal Jaundice

Summary: background: despite widespread phototherapy usage, many newborn infants remain in need of other lines of invasive therapy such as intravenous immunoglobulins and exchange transfusions. objective: to assess the efficacy and the safety of adding fenofibrate to phototherapy for treatment of pathological jaundice in full term infants. design/methods: we conducted a double blinded randomized control study on 180 full-term infants with pathological unconjugated hyperbilirubinemia admitted to the nicu of mansoura university children's hospital. they were randomly assigned to receive either oral fenofibrate 10 mg /kg /day for one day or two days or placebo. primary outcome was total serum bilirubin values after 12, 24, 36, 48 hours from intervention. secondary outcomes were total duration of treatment, need for exchange transfusions and intravenous immunoglobulin, exclusive breast-feeding on discharge, and adverse effects of fenofibrate.


Eligibility criteria:
inclusion criteria: * we included appropriate for gestational age full-term infants with pathological unconjugated hyperbilirubinemia who are candidate for phototherapy according to american academy of pediatrics guidelines exclusion criteria: * full term infants with intrauterine growth restriction, congenital malformations, conjugated hyperbilirubinemia, severe jaundice initially required exchange transfusion, skin abrasions or infection, and preterm infants were excluded

Keywords: fenofibrate, neonatal hyperbilirubinemia, phototherapy
internet assisted career-oriented soft-skills training for transition age youth with mental health conditions

Conditions: Mental Health Wellness 1; Mental Health Wellness 2; Occupational Problems

Summary: the purpose of this study is to evaluate the effectiveness of an internet- assisted career-oriented work-related soft-skills training (icareer) intervention, infused with cognitive behavioral therapy, targeting individuals ages 16-24 with mental health conditions, to improve employment outcomes. the overall objective is to help transition-age youth (tay) with psychiatric disabilities achieve optimal employment outcomes as part of successful transition to adulthood. findings will have implications for enhancing and developing pre-employment services for tay with psychiatric disabilities.

the investigators propose to perform an open trial research study directed toward producing new knowledge about the direct skills teaching intervention for employment related interpersonal "soft" skills. soft skills are generally defined as social, emotional, interpersonal, adaptive, and problem-solving skills (grugulis et al., 2009). the investigators will examine the feasibility of integrated direct skills training modules in social, emotional, interpersonal, adaptive, and problem-solving skills (soft skills at work (ssw)) on improving employment participation and success among transition age youth and young adults (tay) with disabilities ages 18-24.

Eligibility criteria:
inclusion criteria: 1. age between 16 and 24 years 2. must speak english fluently 3. receiving individualized education program (iep)/504 plan or disability services within the past 24 months with primary disability types of psychiatric disability 4. no hospitalizations or suicide attempts within the past 2 months 5. willing to provide informed consent (if younger than 18, parental consent) to participate in the study 6. interested in improving work-related social skills exclusion criteria: 1. current presence of neurological disease or brain injury 2. psychiatric instability such as gross psychosis or acute suicidality 3. current alcohol or substance dependence 4. hospitalization or suicide attempts in the past 2 months

Keywords: transition age youth mental health conditions employment
regular use effect of inhaled ipratropium bromide on airway responsiveness to methacholine in well-controlled asthma

Conditions: Asthma

Summary: study is looking at the development of tolerance to methacholine following regular use of ipratropium bromide in mild asthmatics.

this study is being conducted people with well controlled (mild) asthma to determine if ipratropium bromide taken three times daily for six days (i.e. 2 puffs in the morning, 2 puffs in the afternoon and 2 puffs in the evening) followed by a final dose on the morning of day 7 reduces the effectiveness of this medication on blocking the effect of methacholine challenge.

Eligibility criteria:
inclusion criteria: * airway responsiveness to methacholine * adequate baseline lung function * no respiratory infection or exposure to stimuli that may alter response to methacholine within 4 weeks exclusion criteria: * pregnancy * current smoker * requirement for medications other than salbutamol that will interfere with airway response to methacholine

Keywords: ipratropium bromide methacholine pd20 tolerance
clinical validation of a decompression prototype splint for patients with carpal tunel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: a multicentric randomized controlled trial has been designed to study the effects of a decompression prototype splint on symptoms, functional capacity and nerve conduction studies in patients with carpal tunnel syndrome.

a decompression prototype splint was designed to simulate an manual mobilization that is able to increase the csa of the carpal tunnel and the median nerve in cadavers. these changes are important because they may relate to the decrease in cts symptoms. patients with mild or moderate carpal tunnel syndrome will be selected for the trial. they will be randomized in 2 groups. one group will wear an standard splint for carpal tunnel syndrome and the other the decompression prototype splint.

Eligibility criteria:
inclusion criteria: * be medically diagnosed with carpal tunnel syndrome after electrophysiological tests and present mild to moderate involvement. this test is performed according to the standards established by the "american academy of physical medicine and rehabilitation" * ability to understand and communicate their symptoms and to complete the questionnaires. exclusion criteria: * previous surgery in the carpal tunnel in the same limb other pathologies that may be associated with carpal tunnel syndrome: traumas, pathologies or disorders of the upper limb or cervical spine (cervical radiculopathy, cervical sprain, etc.) or prior cervical surgery * concurrent comorbidities that may be the cause and interfere with the treatment of the carpal tunnel syndrome: diabetes mellitus, hypothyroidism, rheumatoid arthritis, fibromyalgia, reflex sympathetic dysfunction, obesity, renal disease, alcoholism, significant vitamin deficiency and associated viral or bacterial processes * pregnancy * oral drugs, physiotherapy treatment , treatment with splints or infiltrations for carpal tunnel syndrome prior or during the study.
prevalence of corneal astigmatism before glaucoma surgery in chinese patients with primary angle-closure glaucoma

Conditions: Glaucoma, Angle-Closure; Astigmatism

Summary: clear-lens extraction has been considered as first-line therapy for primary angle closure glaucoma(pacg) and application of toric intraocular lens (iols) leads to better postoperative visual acuity, yet little is known about the prevalence of corneal astigmatism in pacg patients. we intend to make biometry examination for chinese pacg patients, to obtain keratometry (k) , axial length (al) and so on, and demographics data will also be recorded. we will study the prevalence of corneal astigmatism before glaucoma surgery in chinese patients with pacg. furthermore, differences of corneal astigmatism between primary angle-closure glaucoma and cataract patients will be explored. finally, the prevalence of corneal astigmatism before glaucoma surgery in chinese patients with pacg will be portrayed and can be instructive to the iols' manufactering.

biometry examination contains keratometry (k) , axial length (al), central anterior chamber depth, visual field loss(mean deviation, md), choroidal thickness(ct), range of goniosynechia, and stage of pacg. demographics data contains age, gender, and eye.

Eligibility criteria:
inclusion criteria: * patients who are phakic and aged 40 years or older , and had newly diagnosed primary angle closure with intraocular pressure 30 mm hg or greater or primary angle-closure glaucoma, will be recruited during preoperative screening at zhongshan ophthalmic center. exclusion criteria: * patients with corneal disease, irregular astigmatism, previous corneal or intraocular surgery, or a history of ocular inflammation will be excluded.
stent thrombosis after tandem lesions thrombectomy

Conditions: Acute Stroke With Large Vessel Occlusion

Summary: the aim is to describe the rate of delayed stent thrombosis after endovascular management of consecutive tandem lesions, in a patient series with systematic follow-up of stent patency. in addition, investigatros aim to research baseline patient characteristics that are associated with a higher risk of delayed stent thrombosis and to evaluate the clinical consequences of stent thrombosis


Eligibility criteria:
inclusion criteria: * patients who underwent endovascular treatments for acute ischemic stroke in strasbourg university hospitals between 01/01/2009 and 01/04/2018 * association of extracranial internal carotid artery (ica) occlusion or stenosis ≥70% using nascet criteria and an intracranial arterial occlusion in the anterior circulation exclusion criteria: - endovascular treatments for complication of surgical carotid endarterectomy

Keywords: acute stroke thrombectomy tandem lesions
evaluation of the effectiveness of the peer bullying consultancy program based on the interpersonal relations model

Conditions: Perr Bulling, Middle School Child, School Nursing, Peplau-Interpersonel Relationship Theory

Summary: the research was conducted in experimental design with intervention-control group and pretest-posttest in order to examine the effectiveness of the peer bullying consultancy program (pbcp), is based on the interpersonal relations model (ipm), on 11-12 years old children who are bullying. the sample group of the study consisted of children (intervention group/n=29; control group/n=32) were attending 5th and 6th grades in two different randomized designated secondary schools after stratified sampling, had high peer bullying determination scale bully behavior. the pbcp was implemented to the children in the intervention group in 2 face-to-face and 5 online individual interviews in 26 days. to increase the peer bullying cognition level, to develop empathy skills, to improve friendship relations, to increase anger control of children who are bullying in intervention group, content suitable for age characteristics was developed within the scope of pbcp various training techniques (brainstorming, educational game, demonstration, case study, video watching) used. the data were collected using sociodemographic information form, the bullying related cognitions scale for children (brcsc), the empathy scale for children and adolescents (esca), friendship relations and anger control assessment form. data collection tools were applied to the children in the intervention group at the beginning and at the end of the pbcp, and to the children in the control group with an interval of 26 days. in the study, children in the intervention group had lower scores on the brcsc; had higher scores on the esca, self-reporting happiness level in friendship relations, sample behavior knowledge level for happy friendship, understanding level of anger symtoms, knowledge level of anger control and self-reporting anger control level than the children in the control group (p\<0.05). it has been determined the pbcp based on the irm is effective for children aged 11-12 who are bullying. it is recommended nurses develop model-based, individual counseling and training program in which different educational techniques are used in accordance with the age characteristics in order to support the growth, development of children who are bullying within the framework of their roles such as advocate, consultant, leader.


Eligibility criteria:
inclusion criteria: * the criteria for inclusion in the study are as follows. * being 11 or 12 years old, * having an internet connection at home, * having a computer and/or phone for internet access, * having at least one standard deviation above the school average in the pbis-ssb sub-dimension score, * the voluntary acceptance of the child and his/her parents to participate in the research exclusion criteria: • having any physical or mental health problems, . having a diagnosis of chronic disease

Keywords: peer bullying consultancy program nurse, interpersonal relations model peblau
obstructive sleep apnea and diabetes mellitus

Conditions: Obstructive Sleep Apnea; Diabetes Mellitus

Summary: the investigators hypothesize that obstructive sleep apnea (osa) contributes to impaired glucose homeostasis and associated vasculopathy, and ncpap treatment of osa should improve glycemic control and vascular function in osa patients with type ii diabetes mellitus. this study aims to investigate the therapeutic effects of ncpap on glycemic control and vascular function in patients with osa and type ii diabetes mellitus.

obstructive sleep apnoea (osa) has been reported to be common (17%) in patients with diabetes mellitus (dm). both osa and dm are highly associated with cardiovascular morbidity and mortality. there is growing evidence that osa may trigger or worsen pre-existing adverse metabolic profile indicative of cardiovascular risk. treatment of osa with nasal continuous positive airway pressure (ncpap) has been shown to reduce blood pressure and hence to reduce the risk of atherogenesis. in patients with dm, the therapeutic effect of ncpap is still not known, it would be important to delineate any independent effect of osa on dm and the therapeutic effect of ncpap on glycemic control to reduce the long term risk of macrovascular and microvascular complications.

Eligibility criteria:
inclusion criteria: 1. patients with type ii dm on a stable medication regimen (on diet / oral hypoglycaemic agents / insulin injections) 2. age 25 - 70 years 3. hba1c \> 7% 4. ahi \>= 15 5. able to give written informed consent exclusion criteria: 1. patients with severe co-existing illness or poor functional performance 2. patients with peripheral vascular diseases, vasculitis / raynaud's syndrome or thrombocytopenia 3. sleep disorders other than osa 4. patients who refuse ncpap treatment for osa 5. excessive sleepiness causing potential harm (e.g. driver) 6. hba1c \>=7% 7. habitual drinker (defined as more than 3 times a week) 8. pregnant or lactating women

Keywords: obstructive sleep apnea type ii diabetes mellitus randomized controlled trial