Kornimate/medical-research-clean huggingface dataset:
inflammatory markers: holep versus turp

Conditions: Prostate Hyperplasia

Summary: aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing holep or tur-p surgery.

benign prostatic hyperplasia (bph) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. basically, surgical techniques in patients with bph are transurethral resection of the prostate (turp), holmium laser enucleation of the prostate (holep), and open prostoactemy surgery. there are many studies comparing the clinical outcomes of turp and holep surgery. however, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.

Eligibility criteria:
inclusion criteria: * asa scores i-iii patients * having benign prostatic hyperplasia * undergoing holep or turp surgery under general anesthesia exclusion criteria: * immune system disease, * diabetes mellitus, * malignancy other than prostate disease, * history of steroid use,
safety of stem cells intrabronchial instillation for silicosis

Conditions: Chronic and Accelerated Silicosis

Summary: the aim of this study was to analyze the safety, pulmonary function, and quality of life data of patients with silicosis treated with intrabronchial instillation of bone marrow derived mononuclear cells (bmdmc, 2x107) through bronchoscopy.

this study will perfume the safety (phase i) study of 10 patients with silicosis treated with intrabronchial instillation of autologous bone marrow derived mononuclear cells (bmdmc, 2x107) through bronchoscopy. the inclusion criteria is: age between 18-50, chronic and accelerated silicosis, characterized with a fibrotic increase in the last two years, fev1 \ 40%, fvc \> 60% and sao2 \>90%, while the exclusion criteria were: smoking, active tuberculosis or other infections, cancer, auto-immune disorders, hematological, hepatic or cardiac diseases, and pregnancy. all patients will be subjected to clinical examination, answered questionnaires of quality of life (sgrq and sf36) and dyspnea score (borg), performed high resolution ct of thorax, pulmonary function tests with dlco and 6-minute walk test and lung perfusion scintigraphy before and 7, 30, 60, 180 and 360 days after treatment. for each patient, 2×107 cells will be labeled with 99mtc. briefly, 500 μl of sterile sncl2 solution is added to the cells and the mixture is incubated at room temperature for 10 min. forty-five mci of 99mtc is then added and incubation continued for another 10 min. after centrifugation (500×g for 5 min), the supernatant is removed and the cells are washed in saline solution. the pellet was also resuspended in saline solution. viability of the labeled cells was assessed by the trypan blue exclusion test, and was estimated to be greater than 93% in all cases. labeling efficiency (%) was calculated by the activity in the pellet divided by the sum of the radioactivity in the pellet plus supernatant and was estimated to be greater than 90% in all cases. whole body and planar scans will be performed 2 and 24h after instillation. perfusion scintigraphy will be performed before and 30, 60, 120 and 180 days after bmdmc therapy. for regional analysis the right and left lungs will be divided into three zones: base, midzone, and apex.

Eligibility criteria:
inclusion criteria:age between 18-50, chronic and accelerated silicosis, characterized with a fibrotic increase in the last two years, fev1 \ 40%, fvc \> 60% and sao2 \>90% exclusion criteria: smoking, active tuberculosis or other infections, cancer, auto-immune disorders, hematological, hepatic or cardiac diseases, and pregnancy

Keywords: pulmonary, silicosis, chronic and accelerated silicosis, autologous transplantation bone marrow cells, stem cells, cell therapy
controlled trial of mental health interventions for torture survivors in kurdistan

Conditions: Depression

Summary: the purpose of this study is to determine the relative effectiveness of three different mental health counseling interventions in the treatment of mental health problems commonly affecting torture and trauma survivors living in kurdistan, iraq.

see above

Eligibility criteria:
inclusion criteria: * at least 18 years old * kurdish * torture survivor * currently has significant depression symptomatology. exclusion criteria: * danger to self or others * already receiving treatment from our treatment provider * not mentally competent to provide informed consent.

Keywords: mental health randomized controlled trial torture
accuracy of fully guided versus half guided implant

Conditions: Complete Edentulism

Summary: six implants will be placed in edentulous maxilla to rehabilitate patients with implant prosthesis.the primary outcome measure will be the accuracy of implant placement, which will be evaluated using cone-beam computed tomography (cbct) scans

study design: this will be a split mouth randomized controlled trial (rct) study. 16 patients missing teeth in the maxillary (upper) jaw and eligible for dental implant treatment will be recruited. interventions will be randomly assigned to the right or the left side of the arch : group 1 will undergo fully guided dental implant surgery. group 2 will undergo partially guided dental implant surgery. study duration: the total duration of the study is estimated to be 5 months. recruitment and enrollment of patients: 1 months dental implant surgery : 3 months data analysis and manuscript preparation: 1 months the key steps are: recruit 16 eligible patients missing teeth in the maxillary jaw. randomly assign right or left side of the maxillary arch of patients to either the fully guided or partially guided implant surgery group. perform cbct (cone-beam computed tomography) scans before and after the implant surgery for both groups. assess the accuracy of implant placement in both groups using the cbct data. conduct statistical analysis to determine if there are any statistically significant differences in implant placement accuracy between the two groups. interpret the results and develop recommendations on the optimal guided surgery technique for rehabilitating the edentulous maxilla using dental implants. the study aims to provide scientific evidence to guide clinicians in selecting the most appropriate guided surgery approach for maxillary implant rehabilitation

Eligibility criteria:
inclusion criteria:all patients underwent a panoramic x-ray and an oral examination. inclusion criteria consisted of patients aged 18 years or older with complete edentulism and adequate bone volume to accommodate six standard implant fixtures measuring 3.7 mm in diameter and 10 mm in length. - exclusion criteria:conversely, patients with partial edentulism, insufficient bone volume for a 3.7 mm diameter and 10 mm length implant fixture, or any local/systemic condition that could impede dental implant surgery were excluded from the study. additionally, patients who smoked more than five cigarettes per day were also excluded. it is important to note that all patients provided written consent prior to their participation in the study. -

Keywords: implants
knee swelling under use of compression stockings after outpatient surgery

Conditions: Knee Pain Swelling

Summary: outpatients who undergo knee surgery are designated two different clinical study groups. group a receives common wrapping after surgery to the first postsurgical day and will be provided with compression stockings for the following 10 days, while group b only receives common wrapping and will not be provided with compression stockings. the investigators are going to investigate the effect of compression stockings on postsurgical swelling and formation of edema on outpatients.

the investigators are planing on investigate the effect of compression stockings on postsurgical swelling and formation of edema. for this purpose the investigators devide outpatients who have undergone knee surgery to two different clinical study groups. group a receives a common compression bandage after surgery to the first postsurgical day and receives compression stockings afterwards for the following 10 days, while group b only receives a common compression bandage to the first postsurgical day. group a will be instructed to wear compression stockings for 24 hours on the first two postsurgical day, afterwards at least for 8 hours a day. preoperatively the investigators are going to determine the volume and circumference of both legs using the bodytronic 600 by bauerfeind. subsequently the measurement will be repeated on the first, forth and tenth postsurgical day. the investigators are going to measure the range of motion, also the patients of both groups will be asked to mark pain and tension on a visual analog scale and write down the amount of time they have been lying, sitting and standing each day. group a will document the amount of time for how long they were wearing compression stockings each day.

Eligibility criteria:
inclusion criteria: * age \> 18 years * signed release form exclusion criteria: * deep vein thrombosis * swelling caused by cardiac, venous or endocrine genesis * dysfunction of the lymphatic system * dysfunction of kidney or liver * use of water withholding medication * massive adiposity * cachexia * epilepsy

Keywords: knee welling outpatient compression stockings
nursing interventions for the prevention of pressure ulcer

Conditions: Pressure Ulcer Prevention

Summary: this study is aimed to assess the effectiveness of nursing interventions on the prevention of pressure ulcers among immobile stroke patients

research question: question 1: what is the effect of nursing educational interventional program on the prevention of pressure ulcers among immobile stroke patients. the interventional program will be provided for the patients over a period of two days in the hospital, then the pressure ulcer prevention program will demonstrated by the researcher. the education and demonstration will consist of proper positioning, frequent change of patients' posture to limit or decrease pressure over the skin, skincare, such as maintaining adequate hydration, keep skin clean, prevent excessive dryness of skin, prevent message over bony prominence, and control moisture. a manual in the form of booklet will be given to the patients and their family caregiver.

Eligibility criteria:
inclusion criteria: 1. both gender 2. patients' age ≥ 18 years old. 3. patients who 1. are at highly risk for pressure ulcer development. 2. braden scale score ≤ 12 3. are able to communicate clearly 4. provide written informed consent 5. do not participate in another study and do not receive any information regarding pressure ulcer prevention. exclusion criteria: 1. patients who have different types of mental problems 2. braden scale score \> 12 3. have history of previous pressure ulcer and are unable to respond to verbal commands. 4. patients who work as a health care provider. 5. patients with different stages of pressure ulcer. -

Keywords: immobile patient stroke pressure ulcers incidence nursing intervention
effect of ferric carboxymaltose on exercise capacity in patients with iron deficiency and chronic heart failure

Conditions: Iron Deficiency; Chronic Heart Failure

Summary: the purpose of this study is to confirm that treatment with iv ferric carboxymaltose improves exercise capacity, physical functioning and quality of life in patients with iron deficiency and chronic heart failure.


Eligibility criteria:
inclusion criteria: * iron deficient subjects with stable chronic heart failure (chf) (nyha ii-iii) on optimal background therapy for chf * reduced exercise capacity * reduced left ventricular ejection fraction * at least 18 years of age and with written informed consent prior to any study specific procedures exclusion criteria: * erythropoietin stimulating agent (esa) use, iv iron therapy, and/or blood transfusion in previous 6 weeks prior to randomisation * exercise training program(s) in the 3 months prior to screening or planned in the next 6 months * chronic liver disease and/or elevated liver enzymes * vitamin b12 and/or serum folate deficiency * subject is not using adequate contraceptive precautions during the study * no other significant cardiac or general disorder that would compromise participation in the study
albiglutide thorough ecg study in healthy volunteers

Conditions: Diabetes Mellitus, Type 2

Summary: this study is designed to investigate the effect of treatment with albiglutide on the cardiac repolarization (corrected qt interval) in healthy male and female subjects. moxifloxacin, a positive control, or moxifloxacin placebo will be given in order to validate the ability of the study to detect a change in the corrected qt interval.

this is a phase i, randomized, double-blind study designed to investigate the effect of treatment with albiglutide given weekly over 6 weeks on the cardiac repolarization (corrected qt interval) in healthy male and female subjects. moxifloxacin, a positive control, or moxifloxacin placebo will be given in order to validate the ability of the study to detect a change in the corrected qt interval.

Eligibility criteria:
inclusion criteria: * healthy male or nonpregnant, nonlactating female * subject considered to be in good health as judged by the absence of clinically significant diseases or clinically significant abnormal laboratory values * bmi is ≥18 kg/m2 and ≤30 kg/m2 * nonsmoker exclusion criteria: * positive test results for hepatitis b, hepatitis c, or human immunodeficiency virus * history of arrythmia or use of antiarrhythmic agents * history of any anaphylactic reaction to any drug * history of significant cardiovascular or pulmonary dysfunction * current or chronic history of liver disease , renal disease, cns disorders, thyroid dysfunction, rheumatoid arthritis * history of alcohol or substance abuse * history of gi surgery that could influence gastric emptying * female and using oral contraception (combined or progestogen only), implants or levonorgestrel, or injectable progesterone, or hormone replacement therapy * history of pancreatitis

Keywords: albiglutide qt interval cardiac repolarization ecg study
a comparison of virco®type hiv-1 testing versus expert interpretation of genotypic results for control of hiv-1 replication

Conditions: HIV-1; HIV Infections

Summary: the investigators seek to determine whether virco®type hiv-1 provides benefits equivalent to those provided by local expert review. the investigators propose that clinic patients of the ruth m. rothstein core center who are having genotypic testing performed will be randomized in a 1:1 fashion to local expert review and to virco®type hiv-1. results of either method will be shared with primary hiv care providers. patient outcomes will be reviewed at a time point equal to or greater than 2 months and 6 months following the change in antiretroviral medications following the testing

patients having some documented genotypic hiv resistance but having more than one fully active medication will be randomized to either local review or algorithmic review by vircotype hiv-1.

Eligibility criteria:
inclusion criteria: * hiv resistance testing that demonstrates resistance to at least one drug * patients of the core center, chicago illinois exclusion criteria: * wild type hiv on resistance testing or less than or equal to one active antiretroviral medication

Keywords: hiv-1 hiv hiv genotypic testing resistance
prospective randomized trial comparing the new endovenous procedures versus conventional surgery for varicose veins due to great saphenous vein incompetence

Conditions: Varicose Veins

Summary: through a prospective rct evaluate and compare the three new endovenous methods for great saphenous vein ablation (radiofrequency, endovenous laser and foam sclerotherapy) versus high ligation and stripping. procedure (proof-of-concept) and patient related (clinical outcome) factors will be studied.


Eligibility criteria:
inclusion criteria: * clinical examinations by an experienced surgeon as well as duplex evaluation. duplex evaluation of both the deep and the superficial system is required but not of the perforating vessels. it is performed by experienced bma or surgeon with profound knowledge in vein diagnosis with duplex. * patients with primary varicose vein disease between age 18 to 75. * signature of informed consent. * varicose veins and duplex verified gsv incompetence defined as \>0,5 seconds reflux time after manual compression in upright position 60 degrees. * vein size \<20 mm in upright position 60 degrees, 2 cm below the sfj. * minimum distance between skin and the gsv in the first 20 cm from the sfj \> 5mm. * ceap classification c2-c5 * bmi \<35 exclusion criteria: * non-consent for randomisation. * age \<18 years. * age \>75 years. * deep vein insufficiency in the same extremity (duplex verified). * vein size \>20mm in upright position 60 degrees below the sfj. * meander and superficial veins with a distance of \<5mm to the skin surface ( rf or laser cannot be applied). * patients with double gsv's and/or lateral accessory insufficient branch. * patients with cognitive disturbances, dementia or unable to understand for any reason the importance of follow up. * earlier operation with hl/s (recurrency). * operated for small saphenous vein (ssv) incompetence the last 3 months. * known abi \<0,9 or history of intermittent claudication or peripheral pulselessness (clinical examination)in either extremity. * patients with recent cancer diagnosis or undergoing cancer treatment. * bmi \>35. * patients with other known medical condition that contradict any of the treatments in the study. * minimum distance between skin and the gsv in the first 20 cm from the sfj \>5mm.

Keywords: varicose vein ligation laser foam sclerotherapy radiofrequency duplex sf36 aberdeen vcss quality recurrence
study to evaluate the efficacy, safety, and pharmacokinetics of exparel, exparel admixed with bupivacaine hcl vs. bupivacaine hcl administered as combined sciatic and saphenous nerve blocks for postsurgical analgesia in subjects undergoing lower extremity surgeries

Conditions: Lower Extremity Surgery; Bunion; Metatarsophalangeal Fushion; Midfoot Fusion; Hindfoot Fushion; Total Ankle Arthroplasty

Summary: this is a phase 3, multicenter, randomized, double blinded, active controlled study in approximately 120 subjects undergoing lower extremity surgeries.


Eligibility criteria:
inclusion criteria: 1. healthy adult male or female volunteers ages 18 or older 2. american society of anesthesiologists (asa) physical status 1, 2, or 3 3. able to provide informed consent, adhere to the study schedule, and complete all study assessments 4. body mass index (bmi) ≥18 and ≤40 kg/m2 exclusion criteria: 1. allergy, hypersensitivity, intolerance, or contraindication to any of the study medications for which an alternative is not named in the protocol (e.g., amide-type local anesthetics, opioids, bupivacaine hcl, nonsteroidal anti-inflammatory drugs \[nsaids\]) 2. concurrent painful physical condition that may require analgesic treatment (such as long-term, consistent use of opioids) in the post dosing period for pain and which, in the investigator's opinion, may confound the post dosing assessments 3. history of, suspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years 4. administration of an investigational drug within 30 days or 5 elimination half-lives of such investigational drug, whichever is longer, prior to study drug administration, or planned administration of another investigational product or procedure during the subject's participation in this study 5. previous participation in an exparel study 6. uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, could interfere with study assessments or compliance 7. currently pregnant, nursing, or planning to become pregnant during the study 8. clinically significant medical disease that, in the opinion of the investigator, would make participation in a clinical study inappropriate. this includes diabetic neuropathy, coagulation or bleeding disorders, severe peripheral vascular disease, renal insufficiency, hepatic dysfunction or other conditions that would constitute a contraindication to participation in the study. 9. currently on a neuromodulating agent neuroleptic agent (e.g., gabapentin, pregabalin \[lyrica\], duloxetine \[cymbalta\], etc.) 10. inadequate sensory function on the foot (monofilament test) 11. chronic opioid use within 30 days prior to randomization (average ≥30 oral morphine equivalents/day)
registry of outcomes from antireflux surgery

Conditions: Gastroesophageal Reflux Disease; Hiatal Hernia

Summary: prospective registry comparing outcomes after laparoscopic treatment of gastroesophageal reflux disease and hiatal hernia.

this is a prospective, multi center, observational database of patients that are having surgical laparoscopic antireflux procedure and/or hiatal hernia repair, including laparoscopic nissen fundoplication and magnetic sphincter augmentation with the linx device. patients meeting registry inclusion and exclusion will be followed for 5 years with standardized quality of life surveys and appropriate standard of care testing. up to 40 sites will participate with total enrollment of 1000 patients. the main objectives are to collect data from everyday clinical practices and track patients from preoperative assessments to 5 years post surgical intervention to evaluate symptoms, medication use and side effects.

Eligibility criteria:
inclusion criteria: * subject must be at least 21years of age and at least the minimum age of majority according to applicable state law. * subject is a suitable surgical candidate, i.e. is able to undergo appropriate anesthesia and endoscopic procedure or laparoscopic surgery. * appropriate indications for and documentation of disease process requiring surgery. (documented gastroesophageal reflux disease by accepted endoscopic or ambulatory reflux monitoring criteria, or have a hiatal hernia that meets accepted criteria for repair (e.g. large paraesophageal hernia with chest pain)). * subject is willing and able to cooperate with follow-up examinations * subject has been informed of the study procedures and treatment and has signed an informed consent for the study. exclusion criteria: * suspected or confirmed esophageal or gastric cancer. * cannot understand trial requirements or is unable to comply with follow-up schedule * pregnant or nursing, or plans to become pregnant during the course of the study * medical illness (i.e. congestive heart failure) that may cause the subject to be non-compliant with or able to meet the protocol requirements or is associated with limited life expectancy (i.e. less than 3 years) * diagnosed psychiatric disorder (e.g. bipolar, schizophrenia, etc.), subjects that exhibit depression that are on appropriate medication(s) are allowable.

Keywords: gerd reflux acid reflux heartburn regurgitation laryngopharyngeal reflux hiatal hernia lpr linx magnetic sphincter augmentation antireflux surgery nissen