Kornimate/medical-research-clean huggingface dataset:
interest of ß 1-3 d glucan assays in screening for the onset of invasive aspergillosis in neutropenic patients with acute leukaemia.

Conditions: Invasive Fungal Infections

Summary: in the context of screening for infectious fungal diseases in patients with malignant haemopathy, and particularly patients with acute leukaemia, the investigator aims to evaluate the performance of an already commercialized but little used serum screening test (fungitell® test) and to determine its place in the management strategy for invasive aspergillosis.


Eligibility criteria:
inclusion criteria: * patients who have been informed about the study * patients over 18 years * patients with acute myeloblastic leukaemia (aml) or lymphoblastic leukaemia (all) who have undergone cytotoxic chemotherapy with curative intent exclusion criteria: * adults under guardianship * patients without national health insurance cover * pregnant or breast-feeding women * allografts and autografts of haematopoietic stem cells (hsc)
correction of metabolic disorders and its effect on respiratory function of lungs in patients with severe covid-19

Conditions: COVID-19

Summary: objective of the study: to investigate the effect of meglumine succinate solution on the dynamics of metabolic blood parameters and respiratory function of the lungs in intensive care patients with new coronavirus infection. an observational prospective study included 105 patients with a severe course of novel coronavirus infection


Eligibility criteria:
inclusion criteria: 1. age 18-70 years; 2. diagnosis of sars-cov-2 nci confirmed by laboratory tests; 3. the lung lesion volume on ct scan is significant or subtotal - ct 3-4; 4. initiation of infusion therapy on the 1st day after patient admission to icu exclusion criteria: * 1) presence of initial indications for transfer to invasive alv at the time of screening; 2) history of reamberin intolerance; 3) administration of other polyelectrolyte solutions with reserve alkalinity carriers; 4) pregnancy and postpartum; 5) severe renal failure requiring renal replacement therapy; 6) severe hepatic failure (child-pugh class c or higher); 7) diabetes mellitus; 8) terminal stage of other chronic incurable diseases

Keywords: covid-19 metabolic disorders respiratory function of the lungs
detection of bloodstream pathogens in hematological malignancies

Conditions: Bloodstream Infection

Summary: * to identify the common bacterial and fungal species causing fungemia and bacteremia in hematological malignancies. * to identify sensitivity pattern for causative microbes. * compare culture on ordinary media with vitek2 (automated microbial identification system) and multiplex polymerase chain reaction (pcr )

sepsis is a global health problem and an estimated 17 million cases of sepsis occur each year in the world .the early initiation of appropriate antibiotic therapy is determinant for the prognosis and survival of patients with bloodstream infections . infections in patients suffering from hematological malignancies are a frequent problem, leading to higher mortality and morbidity, increased costs of health care and prolonged duration of hospitalization. common among these infections are those involving the bloodstream. in febrile neutropenic patients, the attack rate of bloodstream infection was reported to be between 11 and 38% . hematological malignancies by themselves or by their therapeutic strategies, put patients at risk for infections. wide use of antibiotics and prophylactic agents in such patients has led to the development of resistance. the general term fungemia describes the presence of a fungal species in the blood while term bacteremia describes the presence of bacterial species in the blood a positive culture may indicate a widespread infection or commonly, the infection of an intravenous catheter .fungal microbes are abundant in nature and are frequent colonizers on human mucosal surfaces. however, under conditions of impaired immune responses or a break in host barriers, fungi are able to invade normally sterile areas of the human body, where they can cause severe infections that are difficult to recognize and treat and are often ultimately lethal .indeed, recent epidemiological data show that invasive fungal infections (ifis) are frequently encountered in clinical practice, with the most common offenders, being candida spp. and aspergillus spp. in order to effectively eliminate these infections, early diagnosis and species identification are of paramount importance. traditional diagnostic methods such as blood culture is still considered the gold standard .indeed ,novel molecular and non molecular techniques have been developed and currently under clinical evaluation . the vitek 2 is an automated microbial identification system that utilizing growth-based technology. with its colorimetric reagent cards, the vitek 2 offers a state of the art technology platform for phenotypic identification methods. the application of the multiplex polymerase chain reaction pcr method in the diagnosis of bloodstream infections is designed to reduce the time for identification of the microorganisms grown from the positive samples to 24-48 hours, as pathogens are identified directly from a positive blood sample

Eligibility criteria:
inclusion criteria: * hematological malignancy patients on chemotherapy associated with fever exclusion criteria: * age below 18 years old
pilot trial of naltrexone for obesity in women with schizophrenia

Conditions: Obesity; Schizophrenia; Schizoaffective Disorder

Summary: the purpose of this clinical trial is to find out how effective low dose oral naltrexone is on reducing body weight when compared to placebo in women with schizophrenia and schizoaffective disorder.


Eligibility criteria:
inclusion criteria: * women between the ages of 18 to 70 * meet dsm-iv (diagnostic and statistical manual version iv) criteria for schizophrenia or schizoaffective disorder based on scid (structured clinical interview for the dsm-iv) interview * overweight, as defined with a bmi of equal to or greater than 27 kg/m² and continuing weight gain in the past year above 2% of previous years total body weight * be on a stable dose of antipsychotic medication; i.e. at least one month with no dosage change, and two months from an antipsychotic switch; 5) deemed to be symptomatically stable by the clinical staff in the last two months exclusion criteria: * meet criteria for current alcohol or other substance dependence, opioid use for any reason or positive urine drug screen for opiates * a history of dementia, mental retardation or other neurological disorder that may interfere with study ratings * not capable of giving informed consent for participation in this study * ongoing pregnancy * known sensitivity to naltrexone * a medical disorder that is known to cause obesity * use of sibutramine, topiramate, amphetamines or over the counter weight remedies * impaired liver functions (greater than 3 times the upper limit of normal) * diagnosed with polycystic ovary syndrome * currently being treated with insulin * current use of depo-provera or any natural/synthetic hormone treatment known to cause significant weight gain

Keywords: obesity schizophrenia schizoaffective disorder weight loss
a technique using ebl for removal of pedunculated colon polyps

Conditions: Colonic Polyp

Summary: bleeding is the most common complication associated with polypectomy of large pedunculated colonic polyp. although several techniques have been developed to minimize bleeding, none of these methods has become the gold standard. to prevent post-polypectomy bleeding effectively, the investigators developed and attempted a new endoscopic technique for removal of large long-stalked pedunculated colonic polyps using band ligations. this study aims to evaluate the safety and efficacy of a novel technique using endoscopic band ligation for removal of long-stalked pedunculated colon polyps.

a prospective single-center study was conducted. targeted polyps were large (head size \>10 mm) with long stalk length (\>10 mm) in the distal colon. after finding target lesions by standard colonoscopy, conventional upper endoscopy with rubber band (endoscopic band ligation, ebl) was applied to squeeze the mid-portion of the stalk to form an omega shape, which had the dual effect of ligation and compression of feeding blood vessels. after strangulation of the stalk, snare polypectomy was performed at the stalk site just above the ligation. the investigators evaluated several parameters, including completeness of resection, procedure time, and complications, including immediate postpolypectomy bleeding, delayed postpolypectomy bleeding, and perforation.

Eligibility criteria:
inclusion criteria: * polyps with head \>10 mm and stalk length \>10 mm; * location at the distal segments of the colon; and * benign features under endoscopic inspection (absence of ulceration and induration or friability). exclusion criteria: * patients who refuse to sign the consent

Keywords: colonic polyp endoscopic mucosal resection
treatment of lung adenocarcinoma with bronchioloalveolar feature

Conditions: Pneumonic-type Adenocarcinoma (P-ADC); Lung Adenocarcinoma With Bronchiolo-alveolar Feature

Summary: pneumonic adenocarcinoma (p-adc) is defined as a primary lung adc with a radiological pneumonic presentation, usually referred to histologically as adc with a mixed-invasive and bac predominant subtype in the 2004 who classification. surgery is the best therapy for resectable tumors since the effectiveness of chemotherapy is disappointing. in the advanced p-adc diffuse/multifocal types of bac, epidermal growth factor receptor (egfr) tyrosine kinase inhibitors (tkis) (gefitinib and erlotinib) have shown promise, with some rapid, dramatic responses, possibly reflecting specific molecular differences from other non-small cell lung carcinomas.

we therefore conducted a french multicentric phase ii trial (ifct 0401) to evaluate activity and tolerance of gefitinib (250 mg/day) administered as first line treatment in patients with non-resectable p-adc.

Eligibility criteria:
inclusion criteria: * pathologically / cytologically proven adc-p * non-resectable disease * 3-month expected survival * no prior radiotherapy or chemotherapy * age \>= 18 years old * performance status \< 4 (who) * adequate blood biological parameters exclusion criteria: * abnormal initial fibroscopy

Keywords: adenocarcinoma, bronchiolo-alveolar
pancreatic islet transplantation in the anterior chamber of the human eye - a pilot study

Conditions: Type 1 Diabetes Mellitus

Summary: the overall objective is to establish that transplantation of allogeneic pancreatic islet cells into the anterior chamber of a severely visual impaired diabetic human eye is safe and does not cause ophthalmic or systemic complications. furthermore, the change in insulin production, glucose control and hypoglycaemia awareness will be assessed.

investigators intend to transplant 4 type 1 diabetes mellitus patients with compromised vision in one or both eyes due to diabetic or other complications, and who have already received kidney transplantation (i.e., already on immunosuppression). transplantation of allogeneic pancreatic human islets will be performed into the anterior chamber of a single eye with compromised vision. since the recipients are already immunosuppressed due to maintenance therapy for the kidney graft, investigators will only use non-steroidal anti-inflammatory drug (nsaid). only in case of uncontrolled reaction, steroid should be used under guidance of the ophthalmologists. investigators will neither inject local immunosuppressive drugs nor change ongoing immunosuppressive medication in the pilot study. the overall objective is to establish that transplantation of allogeneic pancreatic islet cells into the anterior chamber of a severely visual impaired diabetic human eye is safe and does not cause ophthalmic or systemic complications. furthermore, the change in insulin production, glucose control and hypoglycaemia awareness will be assessed. in this pilot study investigators aim to gain experience in the technique, to obtain preliminary data on the amount of insulin that can be expected per transplanted islet equivalent (ieq) and observe possible local reactions. these data will help to design a future larger study in patients without visual impairment.

Eligibility criteria:
inclusion criteria: 1. type 1 diabetes (american diabetes association criteria) 2. kidney transplant recipient with ongoing immunosuppression 3. at least one eye with extensive loss of vision from hand motion to no light perception due to damage of retina or optic nerve 4. age ≥ 18 years 5. normal cornea with good visualization of the anterior segment 6. patient not eligible or with no wish for standard pancreatic islet into the hepatic portal system or pancreas transplantation exclusion criteria: 1. uncontrolled diabetic retinopathy 2. signs of current infection 3. poor visualization of the anterior chamber

Keywords: pancreatic islet transplantation
unilateral vs. bilateral approaches to hybrid stroke rehabilitation

Conditions: Stroke

Summary: the aim of the project is to compare the effects of unilateral hybrid therapy \[unilateral robot-assisted therapy (rt)\] + unilateral arm training (uat)\] and bilateral hybrid therapy \[bilateral rt + bilateral arm training (bat)\] on motor function, daily function, mobility, life quality, and motor control strategy in stroke patients.


Eligibility criteria:
inclusion criteria: 1. ≥3 months onset from a first-ever unilateral stroke; 2. minimal motor criteria to receive cit (i.e., ≥10º wrist extension and ≥ 10º extension at the thumb and any two other digits); 3. an initial fma-ue score of 10 to 56, indicating mild to moderate and moderate to severe upper extremity motor impairment; 4. no excessive spasticity in any of the joints of the affected arm (shoulder, elbow, wrist, and fingers); 5. able to follow instructions and perform the study tasks (mini mental state examination ≥ 22); 6. without upper extremity fracture within 3 months; 7. no participation in any rehabilitation experiments or drug studies during the study period; and (8) willing to provide written informed consent. exclusion criteria: 1. acute inflammatory disease; 2. major health problems or poor physical condition that might limit participation; and (3) attend any other study in recent 3 months.

Keywords: stroke rehabilitation robot-assisted therapy hybrid therapy
a phase-ii study of raltitrexed/oxaliplatin plus radiotherapy versus radiotherapy in subjects with inoperable esophageal cancer

Conditions: Inoperable Esophageal Cancer Stage I-III

Summary: the aim of this study was to compare raltitrexed/oxaliplatin plus radiotherapy versus radiotherapy in subjects with inoperable esophageal cancer.

108 patients were randomized to receive raltitrexed/oxaliplatin plus radiotherapy (raltitrexed 2.5mg/㎡ d1,oxaliplatin 100mg/㎡ d1,q21d plus radiotherapy 2.0gy/day, 5 times/week,6 weeks.)or radiotherapy ( radiotherapy 2.0gy/day, 5 times/week,6 weeks) in subjects with inoperable esophageal cancer. all patients will receive therapy of six weeks unless disease progression or unacceptable toxicity. patients were evaluated every 3 months .progression-free-survival was the primary endpoint. response rate, overall survival, toxicity of the therapy are other second endpoint.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of inoperable esophageal cancer(squamous cell carcinoma) * measurable disease according to recist criteria * age \> 18 years * who performance score \< 2 * estimated life expectancy of \> 12 weeks * subjects will be considered appropriate to receive systemic chemotherapy and pelvic radiotherapy * hematologic function: wbc ≥ 4.0×109/l, plt ≥ 80×109/l, hb ≥ 10mg/dl * renal function: cr ≤ 1.25×unl * hepatic function: bil ≤ 1.5×unl, alt/ast ≤ 2.5×unl * documented informed consent to participate in the trial exclusion criteria: * subjects with distant metastases * pregnancy or breast feeding. women of childbearing age must use effective contraception * serious cardiovascular disease (congestive heart failure, uncontrollable arrhythmia, unstable angina, myocardial infarction, serious heart valve disease, resistant hypertension) * evidence of bleeding diathesis or serious infection * pregnant or lactating woman * patient participation in other studies
mindfulness to improve elders' immune and health status

Conditions: Stress, Psychologic

Summary: the purpose of the study is to better understand effects of the mindfulness-based stress-reduction (mbsr) program on the physical and emotional health and well-being of adults ages 65 and older. the effects mbsr may have on the immune system is investigated, including how these effects relate to factors such as perceived health, psychological well-being, age, personality, and mood.

this study investigates the effects of mindfulness-based stress reduction (mbsr) on immune responses to multiple concentrations of keyhole limpet hemocyanin (klh) in elderly volunteers. the research design thus capitalizes on the antibody response to a novel, benign antigen to which our subjects will be immunologically naïve. the use of a range of antigen concentrations will provide a sensitive indicator for the effects of intervention. the aims of the study are the following: 1. to examine the effects of mindfulness based stress reduction (mbsr) on immunological outcomes, perceived health, and psychological well-being in a sample of seniors 65 years of age and older. 2. to examine whether treatment effects are moderated by age, personality traits, physical health status, or depression. 3. to examine the effects of behavioral, psychological, and physiological mediators of immune outcome.

Eligibility criteria:
inclusion criteria: * age 65 or older * english speaking * if prescribed antidepressant or anxiolytic medications, must have maintained a stable regimen for eight weeks prior to enrolling exclusion criteria: * receiving immunosuppressive therapy for cancer or other diseases * major, uncorrected sensory impairments * cognitive deficits (mmse \<25, or deficits deemed significant enough to interfere) * history of a psychotic disorder, bipolar disorder, organic brain syndrome, or mental retardation * alcohol or substance abuse within the previous year * severe cardiovascular disease * known allergies to shellfish

Keywords: mindfulness-based stress reduction mbsr seniors immune system keyhole limpet hemocyanin (klh)
contoura vs wavefront optimized ablation

Conditions: Astigmatism

Summary: to evaluate the efficacy, safety and accuracy of contoura topography-guided lasik \& prk in comparison to wavefront optimized lasik \& prk in virgin eyes with astigmatism.

in upper egypt, the second principal cause of blindness was uncorrected refractive errors accounting for 16% of sample population. it was reported that astigmatism (defined as cylinder power \> 0.5 d) was the most common refractive errors in children and adults followed by hyperopia and myopia. laser vision correction has been established over the last 2 decades as a safe and effective intervention to treat refractive errors, being one of the main techniques practiced globally. however, many subjects after lasik had uncorrected distance visual acuity (udva) greater than 1.0, they complain about poor night vision, glare, and double vision. as studies have shown that every 1° deviation of the astigmatic axis could result in loss of correction of 3.3%. even residual astigmatism less than 0.50d could have an actual impact on visual quality. excimer laser ablation used in the correction of refracted errors especially astigmatism may reduce quality of vision, and that is attributed to the induced optical aberrations. the most prevalent of these optical aberrations is the spherical aberration. among multiple sophisticated profiles that developed to optimize visual outcomes, wavefront optimized profile which compensate for corneal curvature to reduce spherical aberration. the topographic guided profiles which consider the shape of the anterior corneal surface. contoura topography guided ablation corrects astigmatic power and axis to create a more uniform, aberration-free cornea. treating astigmatism can be challenging as the conventional patterns of excimer laser treatment of astigmatism is known to be less predictable than that of spherical refractive errors.

Eligibility criteria:
inclusion criteria: * astigmatism (up to 5.0 diopters) or less. * central corneal thickness (cct) of 500 microns or more * estimated residual stromal bed thickness (rsb) of 280 microns or more * subject has provided written informed consent exclusion criteria: * keratoconus * abnormal topography * previous ocular trauma or eye surgery * pre-existing diseases of the vitreous, macula, or optic nerve that can affect visual outcome * patients with uveitis and anterior segment pathology * patients with corneal pathology or severe dry eye * pregnancy or breast-feeding females * uncontrolled vascular or autoimmune disease

Keywords: contoura wavefront optimized ablation lasik prk
sonazoid-enhanced ultrasound in detecting sentinel lymph node in patients with cutaneous melanoma

Conditions: Cutaneous Melanoma; Melanoma

Summary: this pilot phase i trial studies how well sonazoid-enhanced ultrasound works in detecting sentinel lymph node in patients with cutaneous melanoma. sonazoid is a contrast agent that may make it easier to see if the tumor cells have spread to the sentinel lymph node using an ultrasound.

primary objectives: i. to study the imaging feasibility of peri-tumoral administration of sonazoid ultrasound contrast agent for assessment of sentinel lymph node (sln) detection in melanoma. ii. to compare sln detection between sonazoid ultrasound and standard of care (soc) technique. secondary objectives: i. to assess the sonazoid ultrasound (us) imaging appearance of lymph nodes which are shown to be involved with metastatic disease. outline: patients receive sonazoid intradermally (id) and undergo ultrasound imaging. patients also undergo standard of care sentinel lymph node biopsy (slnb). after completion of study treatment, patients are followed up at 24 and 48 hours.

Eligibility criteria:
inclusion criteria: * cutaneous melanoma with breslow depth \> 1 mm or melanoma breslow depth of 0.76 - 1.00 mm in setting of ulceration, extensive regression * mitotic rate \>= 1/mm\^2 * presence of angiolymphatic invasion * deep positive margin * no known allergies to contrast material exclusion criteria: * pregnant or nursing * patients with known cardiac shunt * patients with class ii heart failure or worse, per new york heart association (nyha) classification * patients who have experienced an acute coronary syndrome or angina in the past 6 months * patients who have undergone coronary artery bypass grafting (cabg) or coronary stenting in the past 3 years * patients with evidence of moderate or severe cardiac valvular disease on echocardiogram * patients with evidence of moderate or severe pulmonary hypertension on echocardiogram * patients with stage ii chronic obstructive pulmonary disease (copd) or worse, per global initiative for chronic obstructive lung disease (gold) classification * patients with hypersensitivity to sonazoid or one of its components * patients with hypersensitivity to egg or egg products, because sonazoid contains a chicken egg-derived surfactant (hydrogenated egg phosphatidylserine sodium) * patients who cannot consent for themselves
intra articular botox injection in treatment of osteoarthritis

Conditions: Osteoarthritis Knees Both

Summary: compared the short and long term effects sonography guided of intra articular botox injection to relief pain and improve patients activity of daily living and disability to genicular nerves pulsed radio frequency fluoroscopy guided

compared the short and long term effects of sonography guided intra articular botox injection to relief pain and improve patients activity of daily living and disability to genicular nerves pulsed radio frequency fluoroscopy guided

Eligibility criteria:
inclusion criteria: * osteoarthritis exclusion criteria: * coagulopathy organ failure