Kornimate/medical-research-clean huggingface dataset:
predictive modeling for social needs in emergency department settings

Conditions: Emergency Service, Hospital; Social Determinants of Health

Summary: the overall objective of this study is to support emergency department management of patients' health-related social needs. this study will measure the impact of a decision support system that informs clinicians about which patients are likely to screen positive for a health-related social need. the system uses statistical models to create a health-related social need risk score for each patient. the main questions, the study aims to answer are: * does providing emergency department clinicians with risk scores on health-related social needs increase screening and referral activities? * does providing emergency department clinicians with risk scores on health-related social needs change patients' use of healthcare services? the decision support system with health-related social needs risk scores will be introduced for all adult patients at one emergency department. screening rates, referrals, and subsequent healthcare encounters will be compared with emergency departments that did not have access to the decision support system.


Eligibility criteria:
inclusion criteria: * adults (\>18 years old) * seeking care at indianapolis, indiana area emergency departments (eds). exclusion criteria: * children * encounters by patients that present with a critical illness/injury (e.g. severe trauma patients or those with emergency severity index (esi) classification level 1) * encounters by patients who have been transferred from another inpatient facility * patients that die during the ed encounter * encounters among patients who were ultimately admitted during their ed visits from our analysis

Keywords: informatics
atrial fibrillation research database

Conditions: Anticoagulants and Bleeding Disorders; Atrial Fibrillation

Summary: all patients with atrial fibrillation who are treated with vitamin-k antagonists (warfarin, phenprocoumon) or non vitamin k oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban) in real world settings will be recorded in this register. within this register a characterization of patients and therapy (with regard to medication, dose and duration) will be done. on basis of defined clinical relevant end points the long-term efficacy and safety will be evaluated.


Eligibility criteria:
inclusion criteria: * patients with atrial fibrillation * indication for oral anticoagulant treatment exclusion criteria: * missing informed consent form * missing contact informations for follow up
the chinese early-onset hypertension study (chess)

Conditions: Hypertension

Summary: hypertension (htn) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult population in industrialized societies and over 1 billion people worldwide. chronically elevated blood pressure without well control puts people at increased risk of target organ damages, including stroke, myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and death. especially, these damages are dramatically more severe in the early-onset hypertensive population.

in this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). a complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. blood samples are collected after 12-hour overnight fast and biological variables are determined. genomic dna is isolated from leukocytes according to a standard procedure. the individuals will receive follow-up in an ordinal system. the investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in chinese early-onset hypertension patients.

Eligibility criteria:
inclusion criteria: * in accordance with the diagnosis of hypertension (bp≥140/90mmhg), and less than 40 years when diagnosed exclusion criteria: -

Keywords: hypertension early onset target organ damage
magnetic resonance imaging of the whole body, including diffusion, in the medical evaluation of breast cancers at high risk for metastasis and the follow-up of metastatic cancers

Conditions: Metastatic Breastcancer

Summary: whole-body mri including diffusion is a booming technique. numerous studies have demonstrated its interest in metastatic cancers. breast cancers, especially hormone-sensitive ones, are very osteophilic and bones are the most frequent metastatic site. apart from morphological criteria (lesion size and recist criteria), mri provides quantitative functional criteria (diffusion and adc values). according to a recent study, whole body mri is as good as pet/ct and more effective than bone scintigraphy for the diagnosis of bone metastases for cancers of breast and prostate with a high metastatic risk. therefore, it seems appropriate to study the performance of whole body mri in the pre-therapeutic assessment of breast cancer with a high risk for metastasis and the monitoring of metastatic breast cancer.

whole-body mri including diffusion is a booming technique. numerous studies have demonstrated its interest in metastatic cancers. breast cancers, especially hormone-sensitive ones, are very osteophilic and bones are the most frequent metastatic site. other sites include the lungs, liver, pleura, distant lymph nodes, soft tissue and the central nervous system. metastasis are located exclusively in the bones in 30% of the cases. the most commonly affected bones include the axial skeleton, rich in hematopoietic bone marrow : column, pelvis, skull, ribs, clavicles, the proximal part of the femur and humerus. five percent of breast cancers are directly metastatic and 20 to 30% of localized breast cancers progress to metastatic stage. this potentially affects a large number of patients, with a median survival of 30 to 36 months.patients with bone metastases only have a better survival rate than others: 20% at 5 years. it is therefore important to use a reliable and reproducible examination for the monitoring of treatment response. apart from morphological criteria (lesion size and recist criteria), mri provides quantitative functional criteria (diffusion and adc values). according to a recent study, whole body mri is as good as pet/ct and more effective than bone scintigraphy for the diagnosis of bone metastases for cancers of breast and prostate with a high metastatic risk. however, this is a preliminary study with a limited and heterogeneous cohort of patients. therefore, it seems appropriate to study the performance of whole body mri in the pre-therapeutic assessment of breast cancer with a high risk for metastasis and the monitoring of metastatic breast cancer.

Eligibility criteria:
inclusion criteria: * histological diagnosis of breast carcinoma b5 * axillary lymph node punction c5 or metastatic * performance status from 0 to 2. exclusion criteria: * ferromagnetic metallic foreign bodies (pacemakers, implanted cochlear, neurostimulator, ...) * claustrophobia

Keywords: whole body mri breastcancer
influence of breast milk smell on newborns bilirubin level, duration of time phototherapy and comfort in newborns receiving phototherapyv

Conditions: Newborn Jaundice

Summary: abstract purpose: this research was done for the purpose of determining the impact of breast milk smell administered to term infants hospitalized in neonatal intensive care units (nicu) due to physiological jaundice on their bilirubin levels, length of remaining in phototherapy and comfort. material and method: it is an experimental, randomisation, controlled research. target population of the research consisted of a total of 72 term infants who were hospitalized in the nicu of bilecik bozuyuk public hospital and met the sample selection criteria. our research includes two groups. breast milk smell group and control group. the infants were assigned to the groups via randomization method. sample assignment to the groups was performed using stratification and blocking methods. the infants meeting the research sample selection criteria were stratified according to their postnatal age and then assigned to each group equally (blocking) by lot. however, two infants in the control group were excluded from the research at the request of their parents as the research continued. thus, the research was completed with a total of 72 infants; 37 in the breast milk smell group and 35 in the control group. in the research, the data were collected using "personal data collection form", "phototherapy follow-up chart" and "neonatal comfort behavior scale". the data were analyzed using the spss (statistical package for social sciences) 21.0 (ibm corp. relased 2012. ibm spss statistics for windows, version 21.0 armonk, ny: ibm corp.) package software.


Eligibility criteria:
inclusion criteria: * the term baby (37-39+6 weeks) of the newborn according to the menstruation of the mothers * need to have phototherapy treatment for the first time * not taking analgesics and/or sedatives in the last 24 hours * body weight in the range of 2500 - 4000 g * postnatal age of the newborn greater than 48 hours * turkish neonatology society's approach, follow-up and treatment guideline for neonatal jaundice (2014) being a medium and high risk baby according to the table of risk status determination of babies according to postnatal age and transcutaneous or total serum bilirubin values. * not taking any treatment or medication other than phototherapy treatment * the mother and/or father accepting the study is having a baby. exclusion criteria: * having a health problem other than physiological jaundice * findings such as tachypnea, fever * having an invasive procedure other than blood sampling once a day for babies * exchanged babies * babies with rh and ab0 incompatibility * babies with elevated bilirubin levels earlier than 48 hours * discord with family

Keywords: newborn phototherapy breast milk smell
improved successful retrieval rate of hydromark plus breast biopsy site marker in comparison to hydromark as well as improved surgeon satisfaction

Conditions: Breast Neoplasm

Summary: the purpose of the study is to test how successful the retrieval rate of the new hydromark plus breast biopsy site marker in comparison to hydromark.

study objectives primary objective assess the successful retrieval rates of the hydromark plus clip secondary objective determine the level of satisfaction of the surgeon with the retrieval of the hydromark plus clip

Eligibility criteria:
inclusion criteria: * patients with biopsy clips scheduled for surgery with scout localization exclusion criteria: * patients who didn't have surgery, patients younger than 18 years old * patients older than 90 years old * inmates * non-english speakers
non-invasive monitoring for early detection of atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the aim of this project is to recognize the actual frequency of atrial fibrillation in the polish population as well as to determine the independent risk factors for the occurrence of its clinically symptomatic and asymptomatic forms

the af survey is a cross-sectional observational study aimed to assess the prevalence and control of af and its correlation with cvd risk factors in poland, based on a representative sample of adults aged 65+. the main aim of the survey is to assess the prevalence, detectability and control of af, heart failure, vascular diseases, arterial hypertension, stroke, sedentary lifestyle, smoking, lipid disorders, metabolic syndrome, obesity and diabetes, as well as other factors related to cvd risk such as chronic kidney and liver diseases, sleeping disorders, depression and selected psychosocial factors. the assessment of af prevalence with use of the monitoring system developed and validated during the first phase of the project, would be composed of a questionnaire, follow-up data sheet, blood pressure (bp) measurements and a blood sample collection. the survey consists of three visits to subjects' homes (day: 1; 10+/-4 days and 30+/-4 days) and one phone contact one year after first visit and would be performed by trained nurses. the monitoring system would be installed during the first visit for all patients who sign informed consent form and returned at the third visit one month later. the main questionnaire will be completed during the first visit, which included detailed questions about present health status and history of diseases, hospitalizations, and current medications. the socioeconomic part of the questionnaire included questions concerning the personal and family situation, economic status, household structure, leisure activities, hobbies, and social life. during this visit the geriatric scale of depression evaluation will be given to the subject to be self-completed, and will be collected at the second visit. bp readings would be taken three times during each visit to the patient's home. anthropometric measurements are taken twice: at visit one and visit three at the end of the ecg monitoring. blood samples are taken from subjects at the second visit after 10 to 12-hour fasting. the follow-up data sheet would be completed at the initial visit and at the follow-up visit twelve months after inclusion to the survey. the fieldwork is subcontracted to a company specializing in market research projects for the private and public sectors. the transportation of biological material to the central laboratory has been subcontracted to a company with expertise in blood sample transport over long distances. interviewers will be recruited from among professionally active nurses. most of them will be social nurses working within local communities. all nurses participating in the survey will complete special training prepared for fieldwork executors of the nomed-af project.

Eligibility criteria:
inclusion criteria: * age ≥ 65 years exclusion criteria: * age \< 65 years
the effect of aromatherapy applied to the patients in the urodynamic procedure

Conditions: Anxiety

Summary: this randomized controlled study is planned to determine the effect of aromatherapy applied to patients in the urodynamic procedure on patients' anxiety and serum cortisol levels. this study assumes that lavender inhalation in aromatherapy has positive effects on physiological parameters such as blood pressure, heart rate, respiratory rate, serum cortisol level, as well as reducing stress and anxiety.

98 patients in each group will be included in the study (aromatherapy group=49; control group=49). in addition to the routine treatment and care practices of the unit, aromatherapy will be applied to the patients included in the study group. aromatherapy application will be applied to all patients by the same researcher. aromatherapy application will be started 5 minutes before the urodynamic procedure after the patient is taken to the urodynamics room and lavender essential oil will be used with a diffuser until the end of the procedure. routine treatment and care interventions will be applied to the patients included in the control group during the procedure.

Eligibility criteria:
inclusion criteria: * those who signed the 'informed voluntary consent form' to participate in the research, * 18 years and older, * conscious, oriented and cooperative, * able to communicate * urodynamic procedure applied, * no problem in sense of smell, * no chronic respiratory disease (lung cancer, chronic obstructive pulmonary disease, asthma, chronic bronchitis, etc.), * no history of dermatitis against cosmetic odor, * patients without a known history of allergy to the essential oil used exclusion criteria: * those who did not sign the "informed consent form" to participate in the research, * under 18 years of age, * unconscious, without orientation and cooperation, * unable to communicate, * urodynamic procedure is not applied. * having problems with the sense of smell, * having chronic respiratory disease (lung cancer, chronic obstructive pulmonary disease, asthma, chronic bronchitis, etc.), * having a history of dermatitis against cosmetic odor, * having a trait anxiety scale score of 60 and above, * patients with a known history of allergy to the essential oil used

Keywords: anxiety aromatherapy urodynamic serum cortisol
switching to a fixed dose combination of bictegravir/emtricitabine/tenofovir alafenamide (b/f/taf) in hiv-1 infected marginalized populations who are virologically suppressed

Conditions: Human Immunodeficiency Virus I Infection; Drug Use

Summary: in an effort to engage more hiv-infected pwud into care, and ensure treatment adherence and efficacy, simplification of older, multi-tablet regimens is required. newer, more potent molecules can also overcome resistant that has persisted with previous regimens, while simultaneously providing a high barrier to resistance. the co-formulation of b/f/taf is a viable switch-option for patients who have experienced lower adherence with previous regimens due to high pill burden, or for those requiring a more potent regimen due to emergent resistances. the formal evaluation of b/f/taf in this context will allow us to optimize care for hiv-infected pwud.


Eligibility criteria:
inclusion criteria: 1. participant is ≥19 years of age infected with hiv-1 2. participant has an undetectable viral load \<40 copies/ml at screening with any cd4 count and has exhibited any, or all of the following: 1. transient hiv viremia (episodes of hiv viral load between 40-1000 copies/ml) in the past 12 months, or virologic breakthrough (hiv viral load \> 1000 copies/ml) in the past 12 months, or documented instances of non-adherence for a period of more than 7 days or... 2. participant is currently on multi-tablet hiv antiretroviral therapy, including multi-tablet regimens and/or two drug combinations (dual therapy) 3. participant has a history or current indication of illicit drug use. 4. patients infected with hcv and or hbv can be included in this study. 5. if female, participant must have a negative pregnancy test and agree to use, for the duration of the study, a method of birth control that has a history of proven reliability as judged by the investigator. exclusion criteria: 1. they have any documented history of integrase inhibitor resistance 2. they exhibit any of the following: 1. creatinine clearance rate \< 30 ml/min 2. hemoglobin \< 10.0 g/dl 3. absolute neutrophil count \<750 cells/ml 4. platelet count \< 50,000 /ml 5. alt or ast \>5x upper limit of normal (uln) 6. creatinine \> 1.5x uln 3. they are taking medication that is contraindicated with any component of b/f/taf. 4. they are pregnant or breastfeeding. 5. they do not/have not ever used any form of illicit drug use.
protective manual hyperinflation in acute mechanically ventilated trauma patients

Conditions: Critically Injured Mechanically Ventilated Trauma Patients

Summary: this single-blinded randomized study aims to compare two methods of manual hyperinflation (protective - moderate tidal volumes with positive end expiratory pressure) and non-protective (large tidal volume and no positive end expiratory pressure) in ventilated acute trauma patients, to investigate the effect on inflammatory markers, lung compliance, oxygenation and sputum volume.

current evidence in mechanical ventilation supports a "protective lung strategy" that is, smaller tidal volumes and prevention of loss of positive end expiratory pressure (peep). there is concern that manual hyperinflation (mhi) may conflict with this strategy and cause volutrauma and atelectrauma potentially leading to biotrauma. this single-blinded randomized study aims to compare two methods of manual hyperinflation (protective - moderate tidal volumes with positive end expiratory pressure) and non-protective (large tidal volume and no positive end expiratory pressure) in ventilated acute trauma patients, to investigate the effect on inflammatory markers, lung compliance, oxygenation and sputum volume.

Eligibility criteria:
inclusion criteria: * trauma patients * day 1 of admission to intensive care * mechanically ventilated exclusion criteria: * pre-existing lung disease * peep \> 12.5cmh20 * nitric oxide in circuit * haemodynamically unstable * undrained pneumothorax * intracranial pressure \> 25mmhg

Keywords: trauma
a prospective study to investigate contact sensitization using classic and machine learning techniques

Conditions: Allergic Contact Dermatitis

Summary: the goal of this study is to look into the patterns of sensitization to figure out how allergic contact dermatitis (acd), individual susceptibility, and patient characteristics are connected. the joint application of classic statistics and machine learning methods will reveal the relationship between contact dermatitis expressions and several clinical characteristics.


Eligibility criteria:
inclusion criteria: - eligible patients were adults diagnosed with dermatitis who had a positive patch test result on the chemical panel of baseline series of allergens. exclusion criteria: - although there is no consensus for the definitive exclusion criteria from a patch testing, most studies agree that the chronic use of anti-inflammatory treatments, corticosteroids, and cyclosporine, high uv exposure and other chronic dermatoses are factors that might produce false- positive or false- negative results and thus should be avoided.

Keywords: contact sensitization patch test machine learning
effect of short-term oxygen during cpet in pulmonary hypertension

Conditions: Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension; Chronic Cardiorespiratory Disease

Summary: in a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension.


Eligibility criteria:
inclusion criteria: * diagnosis of pulmonary arterial hypertension class i and iv (according to the latest who classification scheme of dana point 2008) * on optimized medical therapy and in stable condition for at least 4 week * desaturate in the 6 minute walking test by at least 4% to values \<92% exclusion criteria: * unstable conditions * pregnant women * patients with pulmonary venous hypertension * patients with relevant concomitant lung disease and severe daytime hypoxemia