Kornimate/medical-research-clean huggingface dataset:
association of tumour grade and sex steroid receptor as a prognostic index in breast cancer

Conditions: Breast Cancer

Summary: null hypothesis: histological grade of tumour bears no relation with the status of sex hormone receptors. alternate hypothesis: both the histological grade of tumour and expression of sex steroid receptors are directly related to each other the investigators aim to; 1. see the relationship of sex steroid receptors with the histological grade of breast cancer. 2. evaluate the efficacy of steroid receptors as a prognostic factor

breast cancer accounts for the largest number of deaths amongst the female population worldwide. it is now considered as a systemic disease even if diagnosed at an initial stage, as the clinical behaviour cannot be accurately predicted. due to this reason, it is subjected to new dimensions of research every day. the aggressiveness of the cancer is directly proportional to the histopathological grade at the time of diagnosis. this is true with reference to the clinical stage at the time of presentation, the probability to metastasize and potential to recur. the idea of steroids receptor expression by the tumour is not new, and to evaluate their status prior to the induction of hormone therapy is a must. the sex steroids, which are produced intratumorally, include estrogen, progesterone, and androgens. they act on their specific receptors present on the cell surface, within the cytoplasm and at the nuclear membrane. it is a measurement of these receptors that decide the potential of an individual to respond to different types of hormones like estrogen receptor blockers and aromatase inhibitors. do the histological grade of tumour bears some relation with the status of these receptors and can investigators predict and rely just on the cellular behaviour of tumour for the purpose of prognosis is still under investigation. this study is designed to see the relationship between the histopathological grade of the tumour with the expression of sex steroid receptors. it will also try to evaluate whether these receptors bear some prognostic value or not.

Eligibility criteria:
inclusion criteria: * all patients diagnosed with breast cancer irrespective of age, gender and clinical stage exclusion criteria: * any patient who lost to follow up

Keywords: breast cancer sex steroid receptors
in depth observational clinical trial of retinitis pigmentosa patients

Conditions: Retinitis Pigmentosa

Summary: typically, clinical research participation favors a specific demographic group, and little research exists on how trial attributes affect participation. as such, this study seeks to analyze data from different demographic groups and check for recurring trends that could provide valuable insights for future retinitis pigmentosa patients.


Eligibility criteria:
inclusion criteria: * is 18+ years old * confirmed diagnosis of retinitis pigmentosa * signed written informed consent exclusion criteria: * inability to perform regular electronic reporting * participant is actively receiving study therapy in another trial * women of childbearing potential without a negative pregnancy test; or women who are lactating.

Keywords: retinitis pigmentosa
phase 1 first in human study of zn-d5 as a single agent

Conditions: Acute Myeloid Leukemia; Non Hodgkin Lymphoma

Summary: phase 1 dose escalation study of zn-d5 in subjects with relapsed or refractory non-hodgkin lymphoma (nhl) or acute myeloid leukemia (aml).

this is an open-label multicenter phase 1 dose escalation study evaluating the safety, tolerability, clinical activity, pharmacokinetics and pharmacodynamics of the novel bcl-2 inhibitor zn-d5 in subjects with (nhl) or (aml) in order to determine the recommended phase 2 dose of zn-d5.

Eligibility criteria:
key inclusion criteria: nhl: relapsed or refractory nhl including dlbcl, fl, mzl, mcl, lcl, lpl and ptc * subjects must have received at least 2 prior lines of therapy and have either failed or not be eligible for any available therapies expected to provide clinical benefit and have measurable disease. aml: primary, secondary, or treatment-related aml, relapsed or refractory to prior therapy, which may include failure of one cycle of induction therapy. * white blood cell count \< 25 × 109/l. cytoreduction prior to treatment is acceptable. * subjects may not be pregnant and must agree to use an effective method of contraception. * eastern cooperative oncology group performance status ≤ 2. * estimated life expectancy of at least 12 weeks. * adequate hematologic and organ function, including creatinine clearance ≥ 60 ml/min. key exclusion criteria: * recent interventions including major surgery, radiation therapy, stem cell transplant. * treatment with anti-neoplastic agents with 5 half-lives. * significant unresolved toxicity from prior treatments including active gvhd. * active central nervous system disease. * clinically substantial myocardial impairment. * prior therapy with venetoclax.

Keywords: bcl-2 inhibitors bh3 mimetics
fmri in monitoring intracerebral stem cell implantation for chronic stroke patients

Conditions: Stroke

Summary: a growing number of studies highlight the potential of stem cell transplantation as a novel therapeutic approach for stroke in animal model. but the stem cell therapy for chronic stroke patients has not been well investigated yet. in this study, the investigators will test the hypothesis that intracerebral peripheral blood hematopoietic stem cell (cd34+) (pbsc) transplantation induces neuroplasticity in chronic stroke patients. the remyelination of corticospinal tract in the lesion side, focal increased perfusion and increased cortical activity in the peri-infarcted area will be monitored by the functional mri after stem cell therapy. the investigators study is aimed to find the potential mechanisms of the functional recovery after stem cell implantation. the investigators also hope to find image surrogate markers for prediction of patient outcome. the possible surrogate markers will be helpful in improving the treatment procedure and patient selection.


Eligibility criteria:
inclusion criteria: * old stroke half an year \~3 year * one-sided mca infarction * nihss stroke scale: 9-20 exclusion criteria: * pacemaker * cerebral aneurysm clips * neurostimulator * metallic heart valves * iud * joint replacement * metal plates * bone or joint pins * vena cava filters * embolization coils * cochlear implants * greenfieid filer * seizures * claustrophobia * bullet/gunshot * prosthesis (non-removeable) * artificial limbs (non-removeable) * surgical slips * metal screws or pins\> * shrapnel/metallic fragments * harrington rod * insulin pump * ever had metal removed from in or around the eye * ever been metal worker (i.e., welder, machinist) * non-removeable hearing aids * birdnest or gianturco filter * pregnant

Keywords: stroke stem cell
the relationship between urine iodine, urine bisphenol a and autoimmune thyroid disease in reproductive women

Conditions: The Effect of Iodine and BPA on AITD in Reproduction Women

Summary: autoimmune thyroid disease (aitd) is the main cause of hypothyroidism in reproduction women, iodine and bisphenol a are the environmental factors for aitd. the research was mainly designed to investigate the effect of iodine and bpa on aitd in reproduction women to provide new evidence for hypothyroidism in reproduction women.

71 patients with thyroid autoantibody positive were treated as aitd group, another 71 healthy reproduction women were selected as normal group. women age, bmi, thyroid disease history, family history, marital and reproductive history, whether the application of iodized salt, thyroid function and thyroid autoantibodies detection were recorded. meanwhile urine iodine, urinary iodine/urinary creatinine, urine bpa and urinary bpa/creatinine were tested. the urine iodine and bpa levels of the two groups were compared. taking aitd as the dependent variable, logistic regression was conducted to analyze whether urinary iodine and bpa were risk factors of aitd.

Eligibility criteria:
inclusion criteria: 1. aitd group: positive thyroid autoantibody (one thyroid autoantibody), normal thyroid function. 2. normal group: thyroid autoantibody negative, normal thyroid function. 3. no previous history of hyperthyroidism or hypothyroidism, no history of thyroid surgery or i131 radiotherapy, and no thyroid hormone or anti-thyroid drugs were used. exclusion criteria: 1. patients with severe liver, kidney, heart and other important organ failure. 2. merger with other autoimmune diseases. 3. amiodarone, iodine contrast agent and other drugs affecting thyroid function are used.

Keywords: iodine bisphenol a autoimmune thyroid disease
evaluation of combinational use of negative pressure wound therapy (npwt) for diabetic foot wounds

Conditions: Diabetic Foot Ulcer

Summary: singapore has one of the world's highest diabetes-related lower limb amputation rates in the world. between 2008 - 2017, 4724/5306 (89.0%) of all major amputations and 6656/7227 (92.1%) of all toe/ray amputations performed in singapore were for diabetic patients. diabetic foot ulcers are generally slow to heal and poor wound management may lead to infection and subsequently major amputations. hence, adequate wound care to achieve wound healing efficiently and effectively is of utmost importance. in the investigators' clinical practice, negative pressure wound therapy has been the dressing of choice to aid wound closure and prevent infective complications. drainage of wound exudates helps to reduce and prevent infection, promote granulation tissue proliferation and induce cell growth. when used in combination with dermal substitutes, graft uptake is improved by further promoting proliferation and encouraging tissue regeneration. wounds can also be closed surgically though primary closure, where the skin is closed and serves as a physical barrier against infection. the technique is not without its pros and cons. primary closure may decrease healing time and reduce need for additional surgery, but these patients are also at risk of recurrent infection and may require more proximal amputation. these may be circumvented with delayed primary closure, which is the surgical closure of the amputation wound at a delayed timing after amputation. this gives the clinical team time to optimize the wound and ensure that there is no underlying infection prior to closure. the experience of npwt + kerecis omega 3 and delayed primary closure have been positive. to the investigators' current knowledge, there is only one case series reported for the use of fish skin graft in combination with npwt for the treatment of acute pediatric wounds and two case series for the use of npwt in diabetic foot wound that has undergone surgical closure. the proposed study would be the first rct to evaluate effects of combination therapy in both open and closed diabetic foot ulcers.


Eligibility criteria:
inclusion criteria: * age 21-100 * first or last toe ray amputation * adequate perfusion (either \>50% stenosis on duplex ultrasound or undergone successful revascularization with \<30% residual stenosis) exclusion criteria: * amputations not at first or last toe * venous ulcers * heel ulcers * osteomyelitis * active infection * patients on imunosuppressant * patients with known allergy to fish * patients unable to give informed consent.

Keywords: diabetic foot ulcer negative pressure wound therapy dermal substitute delayed wound closure
self-monitoring focus groups with vibrant lives pasadena participants

Conditions: Obesity-Related Malignant Neoplasm

Summary: this study investigates how individuals feel about a dietary mobile application. information collected from focus groups and interviews may help doctors and mobile application developers to determine preferences and participant feedback about the appeal and usefulness of a mobile application.

primary objective: i. to gather qualitative data to assess appeal, preference, and usefulness of a food and beverage self-monitoring mobile application. outline: phase i: participants attend 4 sessions of focus groups. phase ii: participants attend virtual zoom interviews or one-on-one interviews.

Eligibility criteria:
inclusion criteria: * pasadena independent school district (isd) employees who have completed the 6-month vibrant lives weight loss program or adults who have completed a weight loss program within the last 12 months
intrapartum fever and histopathological placental findings

Conditions: Histological Placental Inflamation With or Without Fever

Summary: intrapartum fever associated with epidural anesthesia is caused by non infectious causes therefore without histological findings


Eligibility criteria:
inclusion criteria:epidural with and without fever - exclusion criteria: * patients with infectious backgroud or prilinged prom

Keywords: evron
evaluation of dried blood spot for hcv rna testing

Conditions: Hepatitis C, Chronic

Summary: find is preparing a study to evaluate the performance, as measured by sensitivity and specificity, of four centralized assays for the detection of hcv rna using capillary blood collected on dried blood spots (dbs) and plasma separation card (psc).

available data on the performance of hcv rna assays from dbs samples are insufficient to introduce their use in clinical practice. only a few studies have been performed on dbs stored at ambient temperature, while the majority had dbs samples refrigerated or frozen right after collection, which does not mimic real-life settings. additionally, due to the lack of standardized procedures, dbs collection and elution protocols varied across different studies. a large multicentre diagnostic accuracy study using standardized dbs collection and elution protocols validated by test manufacturers is needed to inform national hepatitis programmes and international guideline development groups. test manufacturers need clinical evaluation data to update their regulatory claims and include dbs as an alternative sample type. find is preparing a trial to evaluate the performance, as measured by sensitivity and specificity, of four laboratory-based assays for detection of hcv rna assays using capillary blood collected on dbs/psc. this will be provisional on the manufacturers agreeing to participate, as well as committing to applying to stringent regulatory approval for dbs/psc.

Eligibility criteria:
three different population groups will be considered: 1. individuals at risk of having hcv infection based on positive hcv serology test results inclusion criteria: * aged 18 years or older * able to understand the scope of the trial * provided written informed consent * documented positive result of hcv serology test 2. individuals at risk of having hcv infection based on past and/or current exposure to risk factors inclusion criteria: * aged 18 years or older * able to understand the scope of the trial * provided written informed consent * past and/or current exposure to one of the high risk factors as defined by who and cdc guidelines (appendix i) 3. individuals diagnosed with chronic hcv infection who initiated or completed the anti-hcv treatment with direct acting antivirals (daa) presenting at the clinical site for treatment monitoring or test of cure (i.e. sustained virological response) inclusion criteria: * aged 18 years or older * able to understand the scope of the trial * provided written informed consent * initiated on daa treatment (regardless of type of daa regimen) within 12 months prior to the enrolment to the trial exclusion criteria (for all trial populations): * previously enrolled in the trial * unwilling to provide required volume of fingerstick blood * unwilling to provide required volume of venous whole blood

Keywords: dried blood spots plasma separation card hcv rna test
robotic versus open ventral hernia repair

Conditions: Ventral Hernia

Summary: this is a randomized trial comparing open retromuscular ventral hernia repair to robotic retromuscular ventral hernia repair.

this is a randomized trial comparing open retromuscular ventral hernia repair to robotic retromuscular ventral hernia repair. this is a superiority trial with a primary outcome of length of stay in the hospital, theorizing that robotic retromuscular ventral hernia repairs are superior to open ventral hernia repairs by reducing length of stay by 24 hours. patients will be blinded to the intervention, groups will be in parallel, and the primary outcome (when the patient is discharged) will be determined by a blinded assessor.

Eligibility criteria:
inclusion criteria: * 18 years and older * 7 cm to 15 cm wide hernia midline defects * bmi less than or equal to 45 * patient deemed both an open and robotic candidate by operating surgeon exclusion criteria: * 17 years old or younger * prisoners * pregnant patients * emergent patients * bmi greater than 45 * hernia defects less than 7 cm or greater than 15 cm in width

Keywords: robotic hernia ventral hernia open hernia mesh
nutritional failure in infants with single ventricle congenital heart disease

Conditions: Congenital Heart Disease; Nutritional Failure

Summary: the purpose of this study is to understand the causes of growth failure and to define biochemical markers of nutritional failure in patients with single ventricle congenital heart disease (chd).


Eligibility criteria:
inclusion criteria: * chd infants: infants with a single ventricle chd admitted to cchmc for neonatal medical management or surgical palliation * normal controls: healthy newborns (full-term infants with no known medical problems) recruited from cchmc and private practices. exclusion criteria: * chd infants: 1) premature birth (\<36 weeks), 2) chromosomal abnormalities, 3) major gastrointestinal, pulmonary or neurologic anomalies * normal controls: 1) premature birth (\<36 weeks), 2) chromosomal abnormalities, 3) major gastrointestinal, pulmonary or neurologic anomalies., 4) cardiovascular anomalies
the effect of ketanserin on the microcirculation in sepsis

Conditions: Severe Sepsis; Septic Shock

Summary: this study is an evaluation of the effect of ketanserine on sublingual microcirculation in intensive care patients with severe sepsis.

this is a pilot study, including 10 icu patients with severe sepsis with mfi \< 2,5 after fulfillment of a strict resuscitation protocol. at the start of the study, a baseline sdf measurement is made, when mfi \< 2,5 inclusion in the study is permitted and intravenous ketanserin administration is started and subsequently increased, guided by the effect on sublingual mfi, until a safe maximum dosage is reached. safety margins for hypotension are defined in the study protocol.

Eligibility criteria:
inclusion criteria: * severe sepsis and mfi \< 2,5 after resuscitation exclusion criteria: * age \< 18 year old * pregnant * participation other trials prolonged qt interval

Keywords: microcirculation sdf ketanserin severe sepsis
development of a psychosocial assessment database for reconstructive hand transplantation

Conditions: Arm Injuries

Summary: a prospective multicenter study utilizing standardized instruments for the psychological assessment of hand transplant candidates pre and post-transplant as well as those candidates excluded for transplantation.

the semi-structured psychological interview describes the assessment of significant psychosocial characteristics and it is based on the psychosocial domains of the "transplant evaluation rating scale (ters)" by twillman and colleagues for evaluating organ transplant candidates. the interview guide was developed as a tool to guide clinicians through the interview process for hand transplant candidates. the protocol highlights issues that are specific for reconstructive hand transplantation and give clinicians an immediate understanding of what type of information is necessary to conduct a comprehensive psychosocial assessment. additionally, the psychological assessment provides standardized psychological screening procedures and continuous follow-up ratings by psychometrical testing. the test battery will be performed at the time of initial psychosocial assessment, immediately after transplant, at six and twelve months for the transplant candidates and at initial evaluation, six and twelve months for candidates excluded for transplant.

Eligibility criteria:
inclusion criteria: * 18 years old * undergoing evaluation for hand transplantation exclusion criteria: * unable to complete surveys

Keywords: hand transplantation
debut: diverticulitis evaluation of patient burden, utilization, and trajectory

Conditions: Diverticulitis

Summary: half of all americans over 60 years of age have diverticulitis of the colon. over the last decade, the use of elective colon resection has increased by more than 50%, and diverticulitis is now the leading reason for elective colectomy. surgeons and patients alike have a difficult time deciding if surgery is the best choice to treat diverticulitis. the goal of the debut study is to improve the understanding about how doctors and patients make decisions to have elective surgery for diverticulitis, and the global impact of diverticulitis on patients' lives.

this study will examine both clinical and non-clinical reasons for pursuing surgery, taking into account previously unexplored areas in surgical decision-making including the comprehensive impact of this disease, as well as factors that impact a surgeon's willingness to recommend surgery. ultimately, this patient-centered research approach will help us understand the impact of treatment decisions on a patient's quality of life, work, and clinical symptoms, and will ultimately help to inform our recommendations for the treatment of patients with diverticulitis. the debut study was developed from questions raised by our washington state surgical collaborative, (scoap colon and rectal surgery work group) and will be carried out in clinics and hospitals across washington state, oregon, and california. the investigators invite patients to participate in research activities designed to identify the impact of diverticulitis and treatment options, in order to better understand the outcomes that matter most to patients. patients who are considering surgery or who have received treatment for their diverticulitis will be recruited for study participation. participants will complete a baseline survey via a convenient electronic platform, and follow-up surveys will be sent quarterly for up to four years. these surveys will examine quality of life, overall health, and clinical symptoms to understand what drives patients and surgeons to an operation, as well as how that decision impacts quality of life and recurrent events in patients that choose to have surgery compared to those that do not have surgery. participating surgeons will complete surveys that examine their indications for surgery and surgical outcomes.

Eligibility criteria:
inclusion criteria: * patients with confirmed diagnosis of diverticulitis * patients 18 years of age or older * patients who are able to consent to participate in research exclusion criteria: * patients that have had prior colon resection surgery * patients that do not make their own medical decisions