Kornimate/medical-research-clean huggingface dataset:
evaluation of the rinse with chlorhexidine plus hyaluronic acid mouthwash in periodontal surgical wound healing

Conditions: Periodontal Diseases; Periodontal Pocket

Summary: evaluate the response of the gingival tissues to the use of mouthwash with chlorhexidine and chlorhexidine + hyaluronic acid in terms of healing of the periodontal surgical wound.

patients included in the study will undergo a thorough clinical examination aiming at collecting all the data desired: periodontal parameters of probing pocket depth (ppd) and presence of recession of the gingival margin (rec) will be recorded on six sites/tooth in the area selected for periodontal surgery by a single calibrated examiner using a university of north carolina (unc) 15-mm periodontal probe at a 0.3 n probing pressure. surgery will be performed following a standardized protocol by a single operator. after surgery, patients will be randomly assigned to study groups corresponding to mouth rinse prescription. the mouth rinse will be assigned by an experimenter not involved in the following steps of the study, in order to maintain the examiner blind. the patient will receive a non-labelled mouth rinse to avoid biases both of the examiner and the patient. the patient will also be given a diary for the registration of the number of rinses per day, to be returned to the examiner at t14. the mouth rinse protocol assigned to each study participant includes a 10 ml-rinse for 60 seconds twice-a-day (every 12 hours) for 14 days. the patients will be allocated in one of the three distinct study groups as it follows: * group a: no administration of mouth rinses after surgery (control group) * group b: administration of a hyaluronic and 0.2% chlorhexidine mouth rinse (test group 1) * group c: administration of chlorhexidine 0.2% mouth rinse (test group 2). post-treatment photographs of surgical incision will be taken immediately after periodontal surgery and at 3 (t3), 7 (t7), and 14 (t14) days post-op, in order to allow the evaluation of the degree of wound healing. the degree of surgical healing will be evaluated using the periodontal wound healing index (wachtel classification) on all the incisions, and a score from 1 to 5 will be assigned. at t3, t7, and t14 the following clinical parameters will be recorded for each tooth in the surgical area: ppd, rec, pi, and bop. the clinical examinations will be performed by calibrated examiner blind to group allocation.

Eligibility criteria:
inclusion criteria: * males or females of age range between 18 and 70 years, * good health status, * indication to perform periodontal surgery, * patients willing to give informed consent, * compliance to the study follow-up, * plaque index (pi) score 0 and * bleeding on probing (bop) \<25% exclusion criteria: * pregnancy or breast-feeding, * therapy with oral contraceptives, * indication to antibiotic therapy prior to surgical treatment, * chronic infections, * systemic diseases (including cardiovascular, pulmonary, cerebral, and metabolic diseases), * previous therapy with the mouth rinses employed in the present study, and * smoking habit (\>20 cigarettes per day, and/or pipe or cigar smoking).
effectiveness of the croq'santé nutrition education program in improving food literacy in schoolchildren

Conditions: Obesity Prevention; Cancer Prevention

Summary: background: nutritional factors including diet, physical activity, weight status and alcohol consumption are among the most important preventable risk factors for cancer. interventions are needed to help children make the right choices in a complex food environment. the jdb foundation designs primary cancer prevention projects through health education targeted at young people. it has designed the "croq'santé" project, which aimed to reduce the risks associated with overweight and obesity by improving food literacy of children aged 8 to 11, corresponding to the 4th and 5th grades. briefly, food literacy refers to having the knowledge, skills and attitudes to choose, prepare and enjoy healthy foods. accompanied by their teacher, a class will create a balanced recipe (or re-adapt an existing one) through a series of stages (10 sessions in total), allowing children to explore the foods and stakeholders in the food chain, understand nutrition, cook and taste new flavors. objectives: the primary objective of this study is to evaluate whether the intervention successfuly improves the food literacy of 8- to 11-year-olds. secondary objectives include examining the influence of socioeconomic factors on the program's effectiveness and process evaluation. methods: we intent to conduct a quasi-experimental before-and-after study including 60 classes (approximately 1500 children). the classes in the intervention group will receive the croq'santé program, while the classes in the control group will receive usual school nutrition education. the schools participating in the control group will have the possibility to receive the croq'santé program the following year if they wish. the primary outcome will focus on changes in food literacy, measured using a child-friendly questionnaire administered before and after the intervention. other information will be collected at child level (e.g. gender, age, family composition) and school level (e.g. socioeconomic indicators). expected results: cancer remains the leading cause of death in france and the production of knowledge on the effectiveness of public health interventions is essential to guide prevention strategies. if the croq'santé programme actually shows its effectiveness, it could be scaled up and adapted to different contexts.


Eligibility criteria:
inclusion criteria: * children in 4th and 5th grades * attending a school participating in the study * child and parental consent exclusion criteria: - classes that took part in the questionnaire pre-test

Keywords: food literacy school-based intervention nutrition education prevention program health promotion
avastin for cnv secondary to pattern dystrophy

Conditions: Choroidal Neovascularization Secondary to Pattern Dystrophy

Summary: the natural history of subfoveal cnv secondary to pattern dystrophy is little understood, but it seems that visual function may be preserved only in the short-term follow-up, with progressive deterioration thereafter. photodynamic therapy with verteporfin is the most studied therapeuthic option for this kindf of lesion, but unfortunately, this approach does not appear to guarantee long-term vision stabilization, and alternative therapies should be investigated.

diagnosis of pattern dystrophy diagnosis of subfoveal cnv intravitreal injection of avastin (1.25 mg) in operating room under sterile condition. retreatment on the basis of the detection of disease progression and of lack of central retinal thickness reduction on oct.

Eligibility criteria:
inclusion criteria: * diagnosis of rpd (hyperpigmented yellowish-greyish network, other family members sharing rpd, normal electroretinogram and normal/subnormal electrooculogram) * classic or occult cnv involving the foveal avascular zone's geometric centre exclusion criteria: * conditions other than rpd * intraocular surgery or capsulotomy within the last 2 or 1 months * pregnancy

Keywords: pattern dystrophy choroidal neovascularization intravitreal avastin injection
postoperative quality of life in treated patients with human adjuvant disease

Conditions: Quality of Life; Granuloma, Foreign-Body

Summary: this study aims to describe the quality of life in patients submitted to surgical excision of the adjuvants and injured surrounding tissue. for this purpose, the euroqol questionnaire (eq-5d) facilitates to obtain values of health in the physical, psychological, and social dimensions. it is a standardized non-disease specific instrument to describe and value the health-related quality of life. although there are only five domains, it has been found to cover the most critical dimensions of quality of life.


Eligibility criteria:
inclusion criteria: * diagnosis of human adjuvant disease due to foreign substances injection * treated surgically to remove foreign substance * in a private practice setting and treated all by plastic surgeon senior author. exclusion criteria: * history of antidepressant use during the follow up

Keywords: human adjuvant disease quality of life reconstructive surgery
maternal inflammatory parameters within routine treatment with betamethasone

Conditions: Preterm Birth

Summary: it is the aim of this study to detect the effect of betamethasone on the maternal inflammatory parameters c-reactive protein (crp) and leukocytes of a pregnant woman under threat of preterm delivery, for example because of a cervical infection.

background cortisone influences the maternal number of leukocytes and crp of a pregnant woman. because of that, it is difficult to know if the medical treatment of an infection was successful and accordingly if the diagnosis was justified. methods in this study, the blood results of 75 pregnant women under threat of preterm delivery (week of gestation 23+0 to 34+6), treated with betamethasone will be analysed. 65 pregnant women without complications serve as control group.

Eligibility criteria:
inclusion criteria: * week of gestation 23+0 until 34+6 exclusion criteria: * infectious diseases f.e. hepatitis b or c, hiv * diseases of the thyroid gland 75 patients facing preterm labour 65 patients acting as a control group, without preterm labor

Keywords: preterm birth corticosteroids inflammatory parameters betamethasone leukocytes
experience and technology acceptance of older adults towards a gamified rehabilitative device prototype

Conditions: Knee Osteoarthritis

Summary: title: older adults' experience and acceptance of a 'gamified' rehabilitative device for total knee arthroplasty background: total knee arthroplasty (tka) is a common surgical procedure. good post-operative rehabilitation is needed for successful functional recovery. patients in our institution demonstrated reduced exercise compliance and accuracy during early post-operative rehabilitation. root cause analysis identified 'reduced feedback', 'reduced care continuity' and 'lack of engagement' to be key contributing factors. yet, healthcare resource limitations necessitate new ways of care continuation and patient activation. in response, fun-knee™, an app-based innovation was created. using 'gamification' of rehabilitative exercises, fun-knee™ guides and tracks rehabilitation from post-surgery to after hospital discharge, till outpatient physiotherapy review. the experience and opinions of older adults towards such 'gamified' rehabilitative technology is unknown. purpose: this feasibility study aims to evaluate and develop fun-knee™, a novel, app-based rehabilitation device that 'gamifies' post-tka exercises to improve exercise compliance, effectiveness, and patient activation. our prototype of fun-knee™ was introduced to two cohorts of healthy older adults. users' experience with hardware and software components of fun-knee™, and their acceptance of fun-knee™ for rehabilitation were surveyed. feedback from the first cohort guided prototype refinement. user experience was re-evaluated in the second cohort. methods: community-dwelling adults with no knee pain, 50 years old and above were recruited if they met inclusion criteria. participants were introduced to two 'gamified' exercises within fun-knee™ with standardised instructions. they were instructed to complete one round of the two games at their own time. thereafter, a survey consisting of quantitative responses was administered. statistical analysis were performed using stata (version 13.1, college station, tx: statacorp lp), fisher's exact tests were performed 2-sided at the 5% significance level. qualitative feedback was obtained during individual interview. suggestions for hardware or software refinements to fun-knee™ were collated and implemented. the above process was repeated for the second cohort of participants, using the latest version of fun-knee™.


Eligibility criteria:
inclusion criteria: * cognitively intact (able to follow 3 step commands), community dwelling adults who are 50 years old and above. not currently attending physiotherapy for knee pain. exclusion criteria: * lower limb skin sensitivity, lower limb sensory impairment, open wounds or broken skin, severe vision or hearing impairment, presence of knee pain above 3/10 on numerical rating scale and being english/ chinese illiterate.
phase i/ii intratumoral dc immunotherapy with gemcitabine & xrt in unresectable pancreatic cancer

Conditions: Pancreatic Cancer

Summary: to determine the safety, feasibility and appropriate dendritic cell dose to vaccinate patients with pancreas cancer


Eligibility criteria:
inclusion criteria:1. patients must have histologically or cytologically confirmed adenocarcinoma of the pancreas. the site of the primary lesion should be confirmed endoscopically, radiologically, or surgically to be in the pancreas. 2. patients must be deemed unresectable due to involvement of critical vasculature, adjacent organ invasion, presence of metastasis, or other medical condition making surgical resection unfavorable. 3. patients must have a primary or metastatic lesion measurable in at least one dimension by recist criteria within 4 weeks prior to entry of study 4. more than 4 weeks must have elapsed from the time of major surgery or completion of the last dose of chemotherapy, radiation therapy, investigational therapy and patients must adequately recover from these effects. 5. life expectancy of \>3 months. 6. karnofsky performance status \>70%. 7. patients must have normal organ and marrow functions as defined below: absolute neutrophil count \>1,500/mm3 platelets \>70,000/mm3 total bilirubin \ 60ml/min/1.73 m2 for patients with creatinine levels above institutional normal. albumin \> 2.8 mg/dl 8. patients must have adequate clotting function (platelet \> 70k; inr\<1.4; ptt\<60). 9. age \>18 years. 10. the effects of dcs on the developing human fetus are unknown. for this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control) prior to study entry and for the duration of study participation. should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. 11. no history of autoimmune diseases. 12. ability to understand the study protocol and a willingness to sign a written informed consent document. exclusion criteria:1. patients receiving anticoagulation therapy. 2. patients who have received prior gemcitabine or radiation therapy to the pancreatic bed 3. patients receiving any other investigational agents. 4. patients with known brain metastases will be excluded because of their poor prognosis and because they often develop progressive neurological dysfunction that would confound the evaluation of neurological and other adverse effects. 5. uncontrolled concurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situation that would limit compliance with study requirements. 6. patients who test positive for hepatitis b virus, hepatitis c virus or hiv.
a study to assess treatment with 2 different dosing schedules of trabectidin administered to patients with advanced cancer

Conditions: Liposarcoma; Leiomyosarcoma

Summary: the purpose of this study is to test the safety and effectiveness of an investigational chemotherapy agent in patients with types of advanced cancer referred to as liposarcoma or leiomyosarcoma.

this is an open-label (patients will know the names of the study drugs they receive), randomized (patients will be assigned by chance to receive 1 of 2 treatment schedules with trabectidin) study designed to examine the the survival, safety, and pharmacokinetics (blood levels) trabectedin when administered to patients with 2 types of cancer (liposarcoma or leiomyosarcoma) who have received treatment with other anti-cancer therapy (anthracycline and/or ifosfamide). trabectedin (also referred to as yondelis) is a drug being developed to treat patients with cancer. yondelis will be administered intravenously (i.v.) via a central catheter (tube) into a central vein once a week (0.58 mg/m2 as a 3-hour infusion on days 1, 8, and 15 of each 28-day treatment cycle) or once every 3 weeks (1.5 mg/m2 administered as a 24-hour infusion on day 1 of every 21-day treatment cycle) until disease progression. patients in each arm will be pretreated with 20 mg of dexamethasone i.v. 30 minutes prior to each infusion.

Eligibility criteria:
inclusion criteria: * have advanced liposarcoma or leiomyosarcoma that has metastasized (spread) * have a pathology specimen available for centralized review * have progressive or relapsed (reappearance of) disease, received treatment with anthracycline and/or ifosfamide before enrollment in study, and have at least one measurable tumor lesion * have adequate bone marrow, liver and kidney function * have eastern cooperative oncology group (ecog) performance status 0 or 1 exclusion criteria: * previous exposure to yondelis i.v. formulation, et-743 (ecteinascidin) * cancer that has metastasized (spread) to the central nervous system * active viral hepatitis or chronic liver disease * unstable cardiac (heart) condition including congestive heart failure or angina pectoris (heart pain), myocardial infarction (heart attack) within 1 year before enrollment * history of another neoplastic (malignant or nonmalignant tumor) disease (except basal cell carcinoma or cervical carcinoma adequately treated), unless in remission for 5 years or more before enrollment

Keywords: trabectedin yondelis et-743 ecteinascidin anthracycline ifosfamide dexamethasone intravenous cancer malignant metastatic
evaluation of some prognostic factors in acute aluminum phosphide intoxicated cases

Conditions: Aluminum Phosphide Poisoning

Summary: study of some laboratory and clinical findings which may show the severity of aluminium phosphide toxicity and the need of the cases to be admitted to icu

aluminium phosphide poisoning is a major cause of death in intoxicated and suicidal cases since there is no antidote and there is no specific investigation for it so there is a need for further study to identify the cause of death and the most specific investigation in the case of alp toxicity

Eligibility criteria:
inclusion criteria: 1. history of exposure or intake of aluminum phosphide. 2. clinical picture of acute aluminum phosphide poisoning including severe vomiting, hypotension, abdominal pain, cardio-pulmonary distress. 3. cases of the age of 15 to 45 years old exclusion criteria: - 1. cases with an unclear history. 2. history of co-morbidities or systemic diseases because of the possibility of misleading laboratory results. 3. history of co-ingestion of drugs or another poison.
impact of beds for kids program on child sleep

Conditions: Insufficient Sleep Syndrome; Inadequate Sleep Hygiene; Child Behavior Problems; Emotional Stress

Summary: the primary objective of this study is to evaluate the impact of provision of a child bed through the beds for kids program on objectively measured child sleep, and on daily child behavioral functioning and caregiver functioning over a 14-day period for preschool-aged children.

many lower-socioeconomic status (ses) children live in crowded homes and lack their own bed, which can contribute to insufficient and poor quality sleep and related poor child and family functioning. the beds for kids program provides beds and bedding to disadvantaged children in philadelphia, and has been found to positively impact parent-reported child sleep in a previous pilot study. however, there is a need to determine the impact of the beds for kids program on objectively assessed child sleep, as well as on daily child behavior and caregiver functioning (mood and sleep). the primary objective of this study is to evaluate the impact of provision of a child bed through the beds for kids program on objectively measured child sleep, and on daily child behavioral functioning and caregiver functioning over a 14-day period for preschool-aged children. this is a randomized controlled trial (rct). caregiver-child dyads will be assigned to the intervention group, in which they receive a bed through the beds for kids program after a 7-day period, or to the waitlist control group, in which they receive a bed after a 14-day period. the primary study outcome is the difference between study conditions in actigraph-derived and caregiver-reported child sleep (bedtime, bedtime variability, sleep quality, night wakings, total sleep duration) for days 7 to 14 (bed vs control), as well as compared to baseline. thus, this is a mixed between (bed vs waitlist) and within (days 1-7 vs days 8-14) group design.

Eligibility criteria:
inclusion criteria: * males or females ages 2 to 5 years (24-71 months) and their male or female caregiver reporter (legal guardian) * eligible for the beds for kids program: (a) living without individual bedding (sleeping on the floor, on a sofa, or crowded into one bed with family members); (b) living in a household whose income is at or below 100 percent of the federal poverty guideline. * parent/guardian is english-speaking. * caregiver is legal guardian and can complete informed consent. exclusion criteria: * presence of a chronic medical (e.g., cancer, sickle cell disease) or neurodevelopmental (e.g., autism, trisomy 21) that would impact sleep, including a pre-existing sleep disorder diagnosis (e.g., obstructive sleep apnea) in child. * child or caregiver use of prescription (e.g., clonidine) or over-the-counter medication (e.g., benadryl; melatonin) that could impact the child's sleep or caregiver report of child's sleep. * caregivers/guardians or subjects who, in the opinion of the investigator, may be non-compliant with study schedules or procedures.
dynamic neck function during gait in patients with dizziness

Conditions: Dizziness; Neck Pain; Gait

Summary: this study aims to explore the possible association between dizziness and head-on trunk-movements and thus, neck movement and if this differs to healthy controls. additional, the study will examine the reliability and validity of using wearable accelerometers to examine how the head moves relative to the trunk and to collect normative data on head on trunk movement.

patients with dizziness will be recruited from a ear-nose and throat clinic. after giving written consent the patients will be tested with wearable sensors on their occiput and c6 vertebra during gait. healthy controls will be recruited from students and employees at the western norway university of applied science and go through the same protocol as the patients. the investigators will measure the relationship between the two sensors to explore how patients with dizziness move their-on-trunk during gait. the projects main hypothesis is that patient with dizziness have reduced attenuation of gait-associated head oscillations with increased coupling of head-on-trunk motion, compared to healthy controls. the neck does not compensate for trunk movements, causing the head to follow the movement of the trunk.

Eligibility criteria:
inclusion criteria: locally referred patients to an ear-nose-and throat (ent) clinic at an university hospital for dizziness symptoms. exclusion criteria: any severe neurologic or orthopedic disease affecting gait.