Kornimate/medical-research-clean huggingface dataset:
evaluation and long-term follow-up of patients with allergic and inflammatory disorders

Conditions: Allergy; Asthma; Allergic Rhinitis; Mastocytosis; Atopic Dermatitis; Food Allergy

Summary: this study will evaluate and follow patients with various allergic, hypersensitivity and inflammatory disorders. the protocol is not designed to test new treatments; patients will be managed with standard of care therapies. participants may be referred to other current niaid protocols as appropriate or to new studies as they are developed, but will not be required to join another study. patients with allergic, hypersensitivity or inflammatory disorders between the ages of 3 years and 80 years may be eligible for this study. conditions of interest include, but are not limited to, asthma, allergic rhinitis, mastocytosis, atopic dermatitis and food allergy. participants will have a medical history and physical examination, plus standard tests for diagnosing and treating their specific disorder. tests may include routine blood and urine studies, x-rays or other imaging studies, allergy skin tests and lung function tests. blood samples may be collected for research on immune system cells and other substances involved in immune function. generally, about 2 to 6 tablespoons will be drawn at a time, but no more than 16 ounces will be collected over a 6-week period. nih does not provide emergency medical treatment or treatment for other, unrelated conditions the patient may have. therefore, patients must maintain a personal physician for these purposes.

allergic, hypersensitivity and inflammatory disorders, including but not limited to asthma, allergic rhinitis, mastocytosis, atopic dermatitis and food allergy are exceedingly common disorders. the pathogenesis of these various disorders are being investigated under a number of laboratory of allergic diseases clinical research protocols. this protocol is an evaluation and long term follow-up protocol of such disorders, for the purposes of maintaining a group of patients on which lad investigators draw for our other various protocols. the patients admitted under this protocol also provide training and experience for members of the niaid allergy and immunology fellowship training programs.

Eligibility criteria:
* inclusion criteria: males and females ages 3 years to 80 years. allergic, hypersensitivity or inflammatory diseases. willingness to participate in clinical protocols when appropriate. subjects must maintain a private physician for non-protocol related medical complaints and for emergency medical treatment required for these or other of their disorders. exclusion criteria: unacceptably poor compliance which, in the opinion of the investigator, would interfere with one's ability to study or provide quality medical care for the patient.

Keywords: asthma hypersensitivity peanut allergy eosinophilic esophagitis eosinophilic gastroenteritis
laser therapy in nipples injured during breastfeeding

Conditions: Nipple Trauma

Summary: this study aims to evaluate the effect of low-level laser in pain relief and tissue repair in mothers with nipple trauma during breastfeeding, compared to a control group.

the selection was made through the search of women hospitalized in accommodation beds with nipple trauma, lifting of stipulated criteria, and inclusion of women in the study upon acceptance and signing of the consent form. to collect the data, a group was formed with people trained as evaluators, responsible for election, randomization, filling of first assessment and subsequent assessment forms, recording of photo images and pain evaluation before and after treatment with laser; and applicators, responsible for laser handling and irradiation. data collection followed the following order: filling of the first instrument, breast image capture, suckling observation, identification of pain during the child's breast sucking, laser irradiation and re-identification of pain during the child's breast sucking after laser treatment. the collection of data of this form occurred continuously every twelve hours until repair of the nipple trauma or patient discharge. a minimum of two and a maximum of six assessments were carried out, from the inclusion of the patient in the study (taken as zero hour) to 60 hours postpartum. irradiation, in turn, was performed every 24 hours during the same period, including one to three irradiations per patient in each of the breasts.

Eligibility criteria:
inclusion criteria: women hospitalized in the accommodation system with their children, feeding exclusively directly from the breast and presenting unilateral or bilateral nipple trauma. exclusion criteria: women who were using any other form of treatment for nipple trauma; use of any topical substance in the nipple-areola region; presence of inverted and pseudo-inverted nipple; presence of mastitis; previous history or presence of malignancies; presence of photosensitivity or any adverse reactions to exposure to sunlight; discharge planned for the first day of data collection; women under unfavorable psycho-affective and cognitive situations which prevented assessment of the analog pain scale, photo image record. and observation of breastfeeding; women who had twins, children with gestational age less than 37 weeks, or birth weight less than 2500 grams.

Keywords: nipple/injure breastfeeding pain laser
data collection on the model schools pediatric health initiative at 5 sbhc sites: covid-19 questionnaire

Conditions: COVID-19 Experience

Summary: the model school pediatric health initiative arose out of concern about health access inequities and disparities among some of toronto's most vulnerable children living in our inner-city neighborhoods. it is well documented that illness, emotional difficulties and self-esteem impacts a variety of educational markers including school attendance and performance. providing health care in schools may be the most direct and efficient way to ensure that all children have access to the care they need including diagnosis, management and follow up of multiple health and school related concerns. american research has demonstrated that inner city children who had access to an elementary school-based health clinic (sbhc) had less difficulty receiving treatment for illnesses and injuries, immunizations, and physical examinations. in addition, rates of enrolment and utilization of elementary sbhcs are higher in those children who traditionally have poorer access to health care. given the vast differences in the canadian and american health systems it is important to evaluate sbhcs in canada before long-term implementation. the objective of this study is to collect data including demographic characteristics and clinical features of students attending a shbc at five selected sites in toronto. in light of the covid-19 pandemic, the research team is additionally interested in asking about families' experiences with the pandemic and school closures. it is hypothesized, that these vulnerable children who come from lower income families and/or are newcomers to canada attending these shbcs, are likely to experience more mental health symptoms with the heightened uncertainty surrounding the covid-19 pandemic. this study will be a prospective chart review design. a covid-19 questionnaire will be constructed and administered online at three time points: baseline, 6 months upon completion of the baseline questionnaire, and 12 months upon completion of the baseline questionnaire.


Eligibility criteria:
inclusion criteria: * all students attending a school-based health centre (sbhc) will be included in the chart review and asked to complete an online questionnaire. exclusion criteria: -

Keywords: covid-19 school-based health center mental health
efficacy of nonsteroidal anti-inflammatory drugs in treatment of moderate and severe dry eye disease

Conditions: Moderate to Severe Dry Eye Syndrome

Summary: this clinical trial is to investigate whether nonsteroid anti-inflammatory drops have therapeutic effect on moderate to severe dry eye patients.and compare the efficacy of the two nonsteroid anti-inflammatory drops with topical corticosteroids.


Eligibility criteria:
inclusion criteria: * moderate to severe dry eye syndrome * tear film breakup time \>0 second and ≤5 seconds,or schirmer test(no anaesthesia)≥2mm/5min and ≤5mm/5min * corneal staining≥3 scores exclusion criteria: * allergic to any composition of the drugs under experiment * previous use of anti-inflammatory drugs or immunosuppressive agent * viral,bacterial or fungal infection of the eye * eyelid anomaly * glaucoma or high iop * significant meibomian gland dysfunction
epoetin beta in treating fatigue and anemia in patients receiving palliative care for malignant solid tumors

Conditions: Anemia; Fatigue; Unspecified Adult Solid Tumor, Protocol Specific

Summary: rationale: epoetin beta may cause the body to make more red blood cells and may help relieve fatigue in patients with malignant solid tumors receiving palliative care. purpose: this phase ii trial is studying how well epoetin beta works in treating fatigue and anemia in patients receiving palliative care for malignant solid tumors.

objectives: primary * evaluate the impact of epoetin beta on fatigue and quality of life of patients receiving palliative care for malignant solid tumors. secondary * evaluate the impact of epoetin beta on hemoglobin level (increase \> 2 g/dl). outline: patients receive epoetin beta subcutaneously once a week for up to 3 months. fatigue, quality of life, and hemoglobin and reticulocyte levels are assessed every 4 weeks.

Eligibility criteria:
disease characteristics: * histologically confirmed malignant solid tumor * no hematologic malignancy * hemoglobin \< 10.5 g/dl (anemic) * receiving palliative care only patient characteristics: * life expectancy \> 6 months * negative pregnancy test * fertile patients must use effective contraception * no chronic anemia requiring treatment (e.g., thalassemia or sickle cell disease) * no uncontrolled hypertension * no allergy to any drugs or components used in the study * not a prisoner or under guardianship or trusteeship * no mental disability that impairs a clear understanding of the study requirements prior concurrent therapy: * see disease characteristics * more than 2 months since prior specific anticancer therapy (e.g., chemotherapy, hormonal therapy, targeted therapy, or immunotherapy) * more than 1 month since prior and no concurrent participation in another clinical trial

Keywords: unspecified adult solid tumor, protocol specific anemia fatigue
the monitor study: remote monitoring of a nutrition intervention to optimize treatment response

Conditions: Pancreatic Cancer

Summary: the purpose of the study is to evaluate the feasibility and acceptability of a remote nutrition coaching and monitoring intervention during the 12-weeks of active chemotherapy for borderline resectable and locally advanced pancreatic cancer participants.


Eligibility criteria:
inclusion criteria: * men or women 18 years of age or more * newly diagnosed, in place tumors of the pancreas * no documented or observable psychiatric or neurological disorders that would interfere with study participation (e.g., dementia, psychosis) * able to speak and read english * able to consume food orally * chemotherapy naive * scheduled to receive treatment with chemotherapy * able to provide verbal informed consent exclusion criteria: * women who are pregnant * pancreatic cancer not the primary diagnosis * patients on enteral or parental nutrition * patients with metastatic pancreatic cancer * patients with evidence of impeding bowel obstruction * patients presenting with ascites
the effect of the inspiratory muscle training on respiratory parameters and functional capacity in idiopathic scoliosis

Conditions: Adolescent Idiopathic Scoliosis

Summary: scoliosis is the abnormality of the spine with direct effects on the shape and mechanics of the thoracic cage. adolescent idiopathic scoliosis (ais) is the most common 3-dimensional deformity of the spine which can potentially affect respiratory function, exercise capacity as well as the performance of inspiratory and expiratory muscles. during growth morphological changes of thoracic cage affects the pulmonary tissues and functions. respiratory functions shows negative changes due to cobb angle, curve localization, number of vertebra and onset age in patient with scoliosis. exercise approaches include respiratory training program and aim to improve respiratory functions.it is reported that respiratory muscle weakness is a potent contributor to pulmonary impairment in mild, moderate, and severe forms of scoliosis. studies showed that exercise training and respiratory exercises may improve respiratory function and exercise capacity in patients with ais. thus the aim of this study was to investigate the effect of inspiratory muscle training on respiratory muscle strength, respiratory function and functional capacity in adolescents with idiopathic scoliosis.


Eligibility criteria:
inclusion criteria: * adolescent idiopathic scoliosis diagnosis exclusion criteria: * documented diagnosis any of cardiopulmonary, neurological, orthopedic or mental disorders which may affect the assessment results. * subjects previously involved in exercise training or physiotherapy programs * subjects previously undertaken any of spinal surgeries.

Keywords: adolescent idiopathic scoliosis scoliosis inspiratory muscle training exercise training respiratory exercise training pulmonary function test 6-minute walk test respiratory muscle strength
a pilot study of fish oil supplementation in hemodialysis patients

Conditions: End-Stage Renal Disease Patients on Hemodialysis

Summary: the main goal of this study is to determine whether the american heart association-recommended fish oil dose is efficacious, safe, and tolerable in hemodialysis patients. the secondary objective is to test the effects of fish oil supplementation on inflammatory and cardiovascular markers.


Eligibility criteria:
exclusion criteria: 1. age \<18 2. pregnant individuals 3. fish oil or omega-3 supplementation in past 6 months 4. fish, corn, soybean, gelatin, or vanilla allergies 5. currently enrolled in a dietary or investigational drug study 6. life expectancy \< 3 months 7. ongoing active illness requiring hospitalization 8. malabsorption syndromes 9. chronic heparin or coumadin anticoagulation (??) 10. active bleeding issues
deep brain stimulation as a novel treatment for refractory opioid use disorder

Conditions: Opioid-Related Disorders

Summary: the purpose of this clinical study is to investigate the safety, tolerability, and feasibility of deep brain stimulation (dbs) of the nucleus accumbens (nac) and ventral internal capsule (vc) for participants with treatment refractory opioid use disorder (oud) who have cognitive, behavioral, and functional disability.

the overarching goal of this study is to evaluate the safety, tolerability, feasibility and impact on outcomes of nac/vc dbs for treatment refractory oud. in treatment refractory oud, innovative approaches and more invasive interventions including dbs are warranted to improve outcomes.

Eligibility criteria:
inclusion criteria: * age 22-50 years at time of enrollment. * fulfills current dsm-5 diagnostic criteria for severe oud with at least a 5-year history. * participants may have comorbid sud diagnoses at a mild, moderate or severe level, however, oud must be the primary disorder for which the individual is seeking treatment and the other use disorders must occur in the context of relapse. * at least one lifetime overdose survival. * demonstrated greater than five years of refractory symptoms of oud. exclusion criteria: * diagnosis of acute myocardial infarction or cardiac arrest 1 within the previous 6 months. * past or present diagnosis of schizophrenia, psychotic disorder, bipolar disorder, or untreated depression other than one determined to be substance induced. * unable to undergo mr-imaging

Keywords: deep brain stimulation
comparison of geriatric screening methods in newly diagnosed multiple myeloma patients

Conditions: Multiple Myeloma; Hematologic Diseases

Summary: the purpose of this study is to compare clinical judgment and comprehensive geriatric assessment as screening tools for optimization of treatment for newly diagnosed elderly multiple myeloma patients.

given the growing elderly multiple myeloma population, the increase in therapeutic possibilities and the importance of geriatric screening, this study wants: * to compare clinical judgment with standardized geriatric screening approaches (g8, cga and imwg score) in newly diagnosed elderly myeloma patients and to evaluate their influence on the detection of geriatric problems and on the choice of the anti-myeloma treatment * to evaluate how geriatric scoring and the subsequent treatment choice influences the therapeutic efficacy and toxicities geriatric scoring will be performed in 3 different ways: * by clinical judgment performed by the treating physician * by validated scoring systems independently performed by a trained nurse/ health care worker. initial scoring will be done by the g8 score. if an abnormal g8 score is present (\<= 14), cga will be performed. * based on the cga parameters, the palumbo/imwg geriatric score will be calculated results obtained by physician-based assessment and by geriatric assessment will be compared before treatment initiation. if, and to what extent the knowledge of the ga influences the therapeutic decision of the treating physician will be registered. in addition, we will register which geriatric problems diagnosed by the cga assessment were already known or unknown by the treating physician. after three months of treatment and at the time of disease progression, geriatric assessment will be repeated in order to judge the evolution (disappearance, improvement, worsening) of the scored parameters, or the emergence of new geriatric symptoms.

Eligibility criteria:
inclusion criteria: * newly diagnosed multiple myeloma * age =\> 70 years * no previous anti-myeloma treatment except for local radiotherapy or short course (max 4 days) of high-dose dexamethasone * signed informed consent * patients included in an interventional therapeutic trial are eligible exclusion criteria: * previous systemic anti-myeloma treatment * severe mental or cognitive disorder precluding geriatric assessment * patient refusal to sign informed consent

Keywords: geriatric assessment fit and frail elderly geriatric oncology
effect of physical activity on metabolic syndrome in pregnancy & fetal outcome

Conditions: Obesity; Pregnancy; Diabetes Mellitus

Summary: the purpose of this study is to examine the effect of exercise during pregnancy upon maternal metabolism, including weight gain, fat distribution, and levels of glucose and cholesterol. we will also conduct a pilot study to examine the feasibility of studying the health of infants born to women in this study.

obesity and overweight have become important public health problems in the united states, and measures are urgently needed to address these issues. for many women, pregnancy is a time of excessive weight gain and decreases in physical fitness, both of which may be followed by postpartum weight retention. women who develop hypertension or diabetes mellitus during pregnancy are at higher risk for development of these disorders in the future. because of the implications of pregnancy-related weight gain and the metabolic changes during pregnancy for future maternal health, interventions to maintain or improve fitness during pregnancy may have important downstream health effects. in addition, maternal metabolic parameters and the intra-uterine environment have important implications for neonatal outcomes and subsequent child health. this study will provide data about the effects of an intervention to increase vigorous physical activity during pregnancy on short-term maternal and fetal outcomes.

Eligibility criteria:
inclusion criteria: * pregnant women 18-45 years old receiving prenatal care at mamc exclusion criteria: * women do not have a gallbladder * who do not speak english * are over 14 weeks pregnant at study entry * do not plan to deliver at mamc * have medical contraindications * unwilling to participate in exercise intervention program * are under 18 years of age * currently engaged in a regular vigorous exercise program

Keywords: obesity physical activity pregnancy diabetes mellitus
increasing physical activity of patients with head and neck cancer (i-pap study)

Conditions: Head and Neck Cancer

Summary: generally, patients who have undergone treatments for head neck cancer have a decreased quality of life and experience depression and fatigue. regular physical activity improves emotional well-being, increases immunological response, improves wound healing, lessens fatigue and improves general functionality and quality of life. this study will determine effectiveness of the 12-week exercise intervention program, determine if physically active patients differ in quality of life, depression and fatigue during the course of the study, and determine if the change in physical activity levels is related to changes in immune responses.

the general hypothesis of this research is that patients who have undergone treatments for head neck cancer have a decreased quality of life and experience depression and fatigue. increasing and sustaining physical activity of these patients will improve their emotional well-beings, increase their immunological response, improve wound healing, lessen fatigue and improve their general functionality and quality of life. the purposes of this study are to: (1) determine the effectiveness of the 12-week exercise intervention program in increasing physical activity in head and neck cancer patients; (2) determine if physically active patients differ in quality of life, depression and fatigue during the course of the study; and (3) determine if the change in physical activity levels is related to changes in the immune responses in human.

Eligibility criteria:
inclusion criteria: 1. patients 19 years of age or above (nebraska legal age). 2. patients diagnosed with hnc who are seen at the university of nebraska medical center. 3. patients who have undergone chemotherapy, radiation and/or surgery for their cancer. 4. patients who have completed their cancer treatment at least 3 months prior. 5. patients who have consented to participate in this study with approval by their physicians. 6. patients who have no significant mental impairment. exclusion criteria: 1. patients who are on enteral feeding. 2. patients who are not able to walk or whose surgeons report that walking is not advisable. 3. patients diagnosed with lymphoma, thyroid cancer or melanoma. 4. patients who are on antidepressant medications. 5. patients who are unwilling to return to the clinic at the end of the study - after 12 weeks of intervention. 6. patients participating in another research study involving a therapeutic intervention. 7. patients with chronic medical and orthopedic conditions that would preclude physical activity (e.g., congestive heart failure, recent knee or hip replacements). 8. patients who are at 18 months or more after the start of cancer treatment.