Kornimate/medical-research-clean huggingface dataset:
referred pain patterns infraspinatus muscle

Conditions: Shoulder Pain

Summary: the first aim of the study will be to identify the most common rep pattern and compare its coincidence with that described by travell and simons. second, the study aim will be to verify whether there are any significant differences by sex and types of technique used in regard to the rep pattern of trp 2 of the infraspinatus muscle, an area described as more sensitive.finally, the third aim of the study will be to determine whether deep dry needling will evoke the ltr and rep more easily than manual palpation.

patients will be recruited from a university's employee and student population by advertising at the university. patients with shoulder complaints (described as pain felt in the shoulder or upper arm) will be randomly assigned to either an manual palpation or deep dry needling group. participants will be randomly divided into 2 groups, a deep dry needling group and manual palpation group. visual analogue scale (vas), referred pain (rep) pattern and features of referred pain of the infraspinatus muscle will be all assessed post-technique.

Eligibility criteria:
inclusion criteria: * aged between 18 and 65 years. * to remain seated or in front of data visualization screens (tablets, computers or smartphones) for at least 4 hours a day. * shoulder complaints in the last six weeks. exclusion criteria: * patients with evidence of serious medical illness. * cognitive impairment. * psychosocial disorders. * bilateral affectation of shoulder pain. * pregnancy.

Keywords: shoulder pain trigger points referred pain visual analogue scale
green sun medical dynamic scoliosis brace

Conditions: Adolescent Idiopathic Scoliosis

Summary: this is a pilot study to collect preliminary short-term data concerning the safety and performance of the green sun dynamic brace in a sample of subjects with adolescent idiopathic scoliosis who are currently being treated with a tlso.

the green sun medical dynamic brace (gsm) brace was developed as an alternative to rigid thoracolumbosacral orthoses (tlsos, braces) commonly used to prevent continued curve progression in patients with adolescent idiopathic scoliosis (ais). the brace applies corrective forces to the muscular and bony structures of the spine while preserving range of motion (rom). the orthosis is prefabricated and adjusted for each patient. a series of semi-rigid segments encircle the patient's torso in close contact and are joined by a structure of flexible elements. these flexible (or elastic) elements generate stabilizing forces, providing the necessary immobilization while allowing relative motion of the semi-rigid segments. to date, this brace has been tested in the lab on healthy volunteers. this study will recruit patients currently using a tlso and compare the curve correction achieved in the gsm brace to that in their current brace. after 3 months in the gsm brace, the out-of-brace cobb angle will be measured and compared to that at enrollment. safety will be continually assessed. brace-related quality of life (comfort, stress, interference with activities) will be self-reported. adherence to the brace prescription will be measured using an in-brace temperature monitor.

Eligibility criteria:
inclusion criteria: 1. diagnosis of ais 2. current treatment with a tlso, of ≥5 months' duration 3. existing 3d surface scan of torso and out-of-brace x-ray within the past 6 months 4. one curve apex below t7 5. ability to read and write english 6. age 10-15 years 7. female sex exclusion criteria: 1) parents/patients who decline participation and/or do not sign the consent/assent documents 2) pregnant women 3) unwilling or unable to return for follow-up visits -

Keywords: adolescent idiopathic scoliosis thoracolumbosacral orthosis spinal orthotic health-related quality of life treatment adherence
the effects of combined lifestyle intervention (cli) in patients with inflammatory bowel disease (ibd)

Conditions: Inflammatory Bowel Diseases

Summary: a single-center observational study to investigate the effects of combined lifestyle intervention (cli, in dutch: gecombineerde leefstijlinterventie, gli) in patients with inflammatory bowel disease.

this is an exploratory observational study of ibd patients ≥ 18 years old with a bmi ≥ 30 mg/kg2 or a bmi between 25 and 30 and an increased risk of diabetes or cardiovascular disease, who are or have been referred to the cli. during the 2-year cli program, fitness measurements take place according to cli protocol and by the cli provider: bodyweight, bmi, waist circumference, fat percentage and the eq-5d-5l are recorded at baseline and 1-year and 2-year timepoints. whilst patients are offered a cli referral, willingness to partake will be recorded.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old; * diagnosis of ibd (ulcerative colitis, crohn's disease or ibd-unclassified) confirmed by clinical, endoscopic, and histological evidence prior to screening as per standard criteria; * bmi ≥ 30 mg/kg2 or a bmi between 25 and 30 mg/kg2 and an increased risk of diabetes or cardiovascular disease; * patients that are or have been referred to the cli; * oral informed consent must be obtained and documented in epic. exclusion criteria: * serious underlying disease other than ibd that in the opinion of the investigator may interfere with the subject's ability to participate fully in the study or would compromise subject safety (such as major neurological disorders, certain orthopedic impairments or any unstable, uncontrolled or severe systemic medical disorder); * if female, the subject is pregnant or lactating; * illiteracy (disability to read and understand dutch).

Keywords: lifestyle diet combined lifestyle intervention exercise
serum levels of vitamin d,calcium and magnesium in preschool recurrent wheezers

Conditions: Recurrent Wheezes

Summary: wheezing" is defined as a musical sound caused by the passage of air through narrow respiratory tract airways . recurrent wheeze is defined as three or more episodes of parentally reported wheeze in the past 12 months of various risk factors are associated with recurrent wheezing and asthma: small airway caliber; decreased lung function at birth; viral respiratory infections; environmental pollution; pets; early daycare attendance; passive smoking; parental history of asthma or atopy; obesity; and socioeconomic factors.

there has been growing recognition of the critical extra-skeletal roles for vitamin d in recent years with an explosion of interest in vitamin d across health disciplines including lung disease. recently, vitamin d was found to be low in patients with recurrent wheezes. vitamin d, whether produced in the skin upon sun exposure or ingested from various dietary sources, is converted in the liver to 25-hydroxyvitamin d \[25(oh)d\]. the latter is the major circulating form of vitamin d and is thus used for evaluating the vitamin d status of patients . the flesh of fatty fish (such as salmon, tuna, and mackerel) and fish liver oils are among the best sources of vitamin d and the fortified cereals and milk provide adequate amounts as well. studies in animal models and humans have demonstrated an association of low vitamin d concentrations with atopy and respiratory tract conditions. the mechanism that explains this association is still unclear. it has been suggested that this mechanism is due to the effects of vitamin d status on the regulation of the immune system. the vitamin d receptor is expressed in various cells of the immune system, such as macrophages, monocytes, dendritic cells, and natural killer cells, as well as in b and t lymphocytes. binding of the active form of vitamin d to its receptor leads to an increase in immunomodulatory activity that maintains the balance between the cellular immune response (th1) and the humoral response (th2), in addition to stimulating regulatory t cells. hypomagnesaemia (serum mg level \<0.74 mmol.l-1) has been also suggested to be associated with increased incidence of wheeze, airway hyperreactivity, and impairment of lung function. the mechanisms of action of magnesium (mg) on respiratory airways are multiple and include relaxation of airways smooth muscle, bronchodilatation, anticholinergic effect, and stabilization of the mast cells

Eligibility criteria:
inclusion criteria: * any child with three or more episodes of parentally reported wheeze aged from 1 month to less than 6 years admitted at pediatric department of sohag university hospital. exclusion criteria: * patients with chronic lung and congenital heart diseases. * patients with body mass index (bmi) below 3rd percentile and those ≥ 85th percentile will be excluded to avoid effect of disturbed nutritional status on vitamin d level and occurrence of wheezing.
maximizing flow diversion effect on the treatment of large intracranial aneurysms with embolization devices

Conditions: Intracranial Aneurysm

Summary: investigate the ability of the intra-operative, intra-aneurysmal flow evaluation to assist with the treatment of intracranial large aneurysms using embolization device(s)

the division of neuroradiology at uhn (toronto western hospital) would like to initiate a single center registry study on the treatment of large intracranial aneurysms with pipeline\[tm\] flex embolization devices using optical flow imaging software, "aneurysmflow". the study team will consent patients diagnosed with unruptured brain / intracratial aneurysms ia(s) . the selected patients ,who booked for elective brain aneurysm repair/endovascular treatment with flow diverter devices (fds) called pipeline embolization devices (ped), will qualify for registry participation . during the ped procedure, the study team will be using aneurysmflow software to calculate a new metric called the mafa ratio (mean aneurysm flow amplitude). by calculating the mafa ratios intra-operatively, the interventionalist can adapt the therapeutic strategy in order to maximize the flow diverting effect on inducing complete aneurysm occlusions (thrombosis). additionally, the purpose of this study is to further expand the body of clinical knowledge concerning the relationship between blood flow metrics as determined by the aneurysmflow software and clinical outcome in patients undergoing treatment for intracranial aneurysms (ias) with pipeline and pipeline flex embolization devices. the study team aims to collect data at a 12 month follow-up period for each patient

Eligibility criteria:
inclusion criteria: 1. subject with unruptured, large (≥8mm) saccular aneurysm(s) located in the anterior intracranial circulation and suitable for an endovascular treatment with a flow diverter stent. 2. subject has signed an institutionally approved research informed consent form. 3. subject ≥ 18 years old. exclusion criteria: 1. subject with non-saccular brain aneurysm (s) such as:- dissecting; fusiform; atherosclerotic; mycotic; bifurcational. 2. subject underwent a prior target brain aneurysm treatment with either endovascular (stenting, coiling) or surgical (clipping) techniques. 3. the endovascular treatment of subject's target aneurysm(s) was assisted with coils or intracranial stents (non-fds) before the aneurysmflow calculations. 4. subject with partially thrombosed or recanalized target brain aneurysm(s). 5. subject had prior significant or severe allergy to intra-arterial contrast medium uncontrolled by pre-procedure medications. 6. subject with severe kidney disease (e-gfr \< 60). 7. subject is not willing (or not able) to attend post fds insertion follow up clinic visits requiring dsa, head mri or cta imaging.
contrast sensitivity in glaucoma

Conditions: Primary Open Angle Glaucoma; Secondary Open Angle Glaucoma Due to PEX

Summary: the primary aim of the erlangen´s glaucoma contrast sensitivity-study (egcs-study) is the evaluation of the diagnostic and prognostic validity of a diagnostic procedure, measuring contrast sensitivity. no therapeutic studies are performed.


Eligibility criteria:
* patients: primary open angle glaucoma, secondary open angle glaucoma due to pex * healthy volunteers (for reliability analysis) inclusion criteria: * age \> 18 * best corrected visual acuity 0.8 or better * european exclusion criteria: * eye diseases: infantile glaucoma, angle glaucoma, secondary open angle glaucoma, wich are not due to pex, diseases involving retina, condition after ophthalmological operations or trauma, cataract, diseases concerning the refractive system, age-related macular degeneration, diabetic retinopathy, optic neuropathy (ms, neuritis), amblyopia * any neurological diseases * systemic diseases with potentially ocular involvement (e.g., diabetes mellitus) * systemic drugs with potentially ocular involvement * ocular drugs
feasibility of dynamic muscle stimulation + radiofrequency for improving blink quality in subjects with dry eye disease

Conditions: Eyelid Diseases; Eyelid Movement Disorders; Dry Eye; Dry Eye Syndromes; Skin Laxity

Summary: to demonstrate that dmst + rf improves eye blink quality in subjects with dry eye disease

the purpose of the study is to demonstrate that a combination of dmst and rf applied on the periocular skin below the lower eyelids improves eye blink quality in subjects with moderate to severe signs and symptoms of dry eye disease.

Eligibility criteria:
inclusion criteria: * subject is able to read, understand and sign an informed consent form (icf) * 22 or older * lower lid laxity, as clinically judged with lower lid dt and the snapback test * moderate to severe osdi (larger or equal to 23) * tbut smaller or equal to 5 sec in both eyes exclusion criteria: * abnormally high blink rate, as estimated by the study investigator * any ocular surgery or eyelid surgery, within 3 months prior to screening * blepharoptosis * moderate or severe floppy lid syndrome * corneal dystrophy * exophthalmos * thyroid eye disease * ocular chemical injury or burn * limbal stem cell deficiency * facial nerve palsy * blepharospasm * hemifacial spasm * corneal neuropathy * pregnant or nursing women * participation in a different study * any condition revealed whereby the study investigator deems the subject inappropriate for this study
the effects of platelet rich plasma on the integrity of rotator cuff repair

Conditions: Rotator Cuff Tear Arthropathy

Summary: the purpose of this study was to determine the effect of platelet-rich fibrin matrix (prfm) augmentation to at-risk arthroscopic rotator cuff repairs on healing rates and functional outcome scores. the investigators performed an observational cohort study in which a consecutive series of patients with rotator cuff tears at risk for retear was prospectively evaluated after arthroscopic repair augmented with prfm. clinical and magnetic resonance imaging (mri) outcomes of the prfm-augmented repairs were compared with historical controls with similar at-risk tears without prfm augmentation.

increased age, larger tear size, and more advanced fatty degeneration of the rotator cuff musculature have been correlated with poorer healing rates after rotator cuff repair. platelets are an endogenous source of growth factors present during rotator cuff healing. the investigators hypothesis is that augmentation of rotator cuff repairs with platelet-rich fibrin matrix (prfm) may improve the biology of rotator cuff healing and thus improve functional outcome scores and retear rates after repair. rotator cuff tears at risk for retear were prospectively identified using an algorithm; points were assigned for age (50-59 years = 1; 60-69 years = 2; .70 years = 3), anterior-to-posterior tear size (2-2.9 cm = 0; 3-3.9 cm = 1; .4 cm = 2), and fatty atrophy (goutallier score 0-2 = 0; goutallier score 3-4 = 1). three points were required for enrollment. arthroscopic rotator cuff repair was performed with the addition of prfm. preoperative and 1-year postoperative magnetic resonance imaging (mri) and functional outcome scores were obtained. imaging and functional outcomes were compared with historical controls meeting the same enrollment criteria. enrollment for the study began in september 2008 and continued until march 2010.

Eligibility criteria:
inclusion criteria: * algorithm score greater and equal to 3 * both men and women over the age of 50 * full-thickness rotator cuff tear at least 2 cm in size * tear repairable by arthoscopic-only techniques exclusion criteria: * inflamation joint disease * active use of oral steroids * irreparable rotator cuff tear * subscapularis tear requiring open repair * claustrophobia * prior rotator cuff sugery on the affected shoulder * failure to return for follow-up magnetic resonance imaging scan

Keywords: rotator cuff repair arthroscopic platelet-rich plasma platelet-rich fibrin matrix outcomes tendon healing magnetic resonance imaging
effect of nitropaste in chest masculinizing surgery

Conditions: Gender Dysphoria

Summary: nitropaste is a topical agent that contains 2% nitroglycerin. it is an effective vascular smooth dilator, with more powerful effect on venous vasculature than arterial vasculature. while its main indication is for angina pectoris, there have been many studies showing improved survival of axial and random pattern flaps. furthermore, recent clinical studies highlight significantly decreased mastectomy flap wound complication and need for sharp debridement. nitropaste has low rates of side effects and is very well tolerated in general. to this date, there's no study that investigates its utility on patients who are undergoing chest masculinizing surgery. the purpose of this study is to investigate the potential utility of nitropaste in reducing rates of wound complications in patients undergoing chest masculinizing surgery.

nitropaste is a topical agent that contains 2% nitroglycerin. it is an effective vascular smooth dilator, with more powerful effect on venous vasculature than arterial vasculature. while its main indication is for angina pectoris, there have been many studies showing improved survival of axial and random pattern flaps. furthermore, recent clinical studies highlight significantly decreased mastectomy flap wound complication and need for sharp debridement. nitropaste has low rates of side effects and is very well tolerated in general. to this date, there's no study that investigates its utility on patients who are undergoing chest masculinizing surgery. the purpose of this study is to investigate the potential utility of nitropaste in reducing rates of wound complications in patients undergoing chest masculinizing surgery utilizing double incision with free nipple grafting technique. the investigators will conduct a prospective, randomized, single-blinded study and compare nitropaste vs. no nitropaste on mastectomy flaps. nitropaste will be applied intraoperatively and the patients will not have to re-apply it. follow up will occur on post-op day 5, 2 weeks, and 6 weeks during their routine postop visits. a study coordinator will document the condition of free nipple grafts and any other wounds at surgical site if present, which will be the primary outcome. any complications including hematoma, seroma, infection, hypertrophic scarring, need for sharp debridement, 30 day ed visit or admission rates will be documented as secondary outcome.

Eligibility criteria:
inclusion criteria: * any adult (18 or older) patients of any gender identity who are undergoing chest masculinizing surgery with double incision and free nipple grafting. exclusion criteria: * minor patients (younger than 18) * anyone who's not getting free nipple grafting * anyone who's not utilizing double incision pattern * prisoners, anyone who is allergic to nitropaste * anyone who is taking phosphodiesterase inhibitor (ex)sildenafil, tadalafil, vardenafil) * anyone who's taking soluble guanylate cyclase stimulator riociguatdz

Keywords: gender affirming surgery chest masculinizing surgery nitropaste wound healing
hearing loss in older adults study

Conditions: Hearing Loss, Sensorineural; Hearing Loss, Bilateral

Summary: this is a prospective, 1:1 randomized controlled trial of immediate versus delayed cochlear implantation (ci) on hearing handicap, communicative function, loneliness, mental wellbeing, and cognitive functioning. participants are randomized 1:1 to an immediate cochlear implant intervention group versus a hearing aid control intervention.


Eligibility criteria:
inclusion criteria: * community-dwelling * proficient in english * oral communicator * pta (500, 1000 \& 2000 hz) ≥ 70 db hl hearing loss duration ≥1 and no more than 30 years * active daily hearing aid users * hhie-s score greater than or equal to 24 * moca score greater than or equal to 20 * post-linguistic onset sensorineural hearing loss and meet applicable fda and/or medicare candidacy criteria for cochlear implantation * willing to consent for the study, to be randomized to either group, to utilize bimodal hearing for the duration of the trial (if clinically appropriate), and follow the study protocol exclusion criteria: * prelingual or perilingual severe-to-profound hearing loss * previous cochlear implantation in either ear * hearing loss of neural or central origin * permanent conductive hearing impairment (e.g. otosclerosis) * medical, audiological, or psychological conductions that might contraindicate participation in the clinical investigation * self reported disability in 2 or more activities of daily living * vision impairment worse than 20/40 on a near vision card
ketamine effects on learning in eating disorders

Conditions: Anorexia Nervosa; Atypical Anorexia Nervosa

Summary: this is a single site, single dose clinical trial of intravenous (iv) ketamine for medically hospitalized adolescents and young adults with anorexia nervosa or atypical anorexia nervosa. eating disorder symptoms will be measured pre- and post-ketamine infusion. investigators hypothesize that ketamine will increase cognitive flexibility, making medical hospitalizations less distressing by improving the ability to learn new, positive associations with food.


Eligibility criteria:
inclusion criteria: 1. age 16-26 years old 2. meets diagnosis of anorexia nervosa (an) or atypical anorexia nervosa (atypical an) per dsm-5 criteria on admission 3. admitted to the medical hospital for malnutrition 4. no changes to psychiatric medications for month prior to trial enrollment 5. agree to use a highly effective form of contraception for at least two weeks following ketamine administration 6. have an outpatient primary care provider, medical provider, or behavioral health provider or psychiatrist who is actively managing or coordinating care exclusion criteria: 1. lifetime history of any psychotic disorder 2. moderate or severe substance use disorder 3. pregnancy as indicated by a positive urine pregnancy test during screening, lactation, or the intention of becoming pregnant within 3 months of entry into this trial 4. electroconvulsive therapy (ect) or transcranial magnetic stimulation (tms) treatment within 30 days prior to enrollment 5. intellectual or developmental disability 6. high risk for self-harm/suicide 7. active laxative misuse or abuse 8. biochemical refeeding syndrome or electrolyte abnormality 9. cardiac abnormalities identified on admission 10. taking medications that would be unsafe to administer with ketamine 11. other medical condition or diagnosis, physical exam finding, laboratory abnormality, or health risk that would increase the risk of adverse events, at the discretion of the investigators

Keywords: anxiety depression anorexia psychotropic drugs feeding and eating disorders physiological effects of drugs cognitive flexibility