Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of oxymorphone immediate release in post-surgical acute pain

Conditions: Acute Pain

Summary: the purpose of this study is to evaluate the analgesic efficacy and safety of two doses of oxymorphone immediate release (ir) compared to placebo and oxycodone in post-surgical pain.

following abdominal surgery and after sufficient washout from post-surgical analgesia, patients were randomized to one of the following four treatment groups; 1) oxymorphone ir 10 mg, 2) oxymorphone ir 20 mg, 3) oxycodone ir 15 mg, or 4) placebo. total duration of treatment was 48 hours. patients were required to take the study medication every 4-6 hours. after the first dose, periodic pain assessments were performed for the first six hours. subsequently, patients were required to assess their current pain intensity and average pain intensity since the last dose of study medication just prior to every dose.

Eligibility criteria:
inclusion criteria: * male or female patients 18 years of age or older * patients undergoing surgery through an abdominal incision of at least 3 cm who are expected to be hospitalized for at least 36 hours and are expected to subsequently require at least 48 hours of oral opioid therapy. * washout of at least 45 minutes for parenteral and 4 hours for im analgesia. * initial pain intensity score of at least 50 mm on a 100-mm vas and a categorical pain rating of moderate or severe on a scale of none, mild, moderate, or severe. * written informed consent. exclusion criteria: * known allergy or significant reaction to opioids. * history of chronic opioid use or opioid abuse within 6 months prior to study entry. * history of alcohol or substance abuse within the last 3 years. * have been a participant in a study of an investigational drug or device within 30 days prior to study entry. * have been a previous participant in an oxymorphone clinical trial. * are currently taking or have taken a monoamine oxidase inhibitor (maoi) drug within 2 weeks prior to study entry. * are currently taking or have taken st. john's wort \>1000 mg/day within 2 days prior to study entry. * use of long-acting oral and parenteral analgesics (opioid, non-opioid or non-steroidal anti-inflammatory drug \[nsaid\]) within 12 hours (at least 24 hours for cyclooxygenase-2 \[cox 2\] analgesics) prior to receiving study medication. * are not stabilized on the following medications for at least 4 weeks prior to dosing: tricyclic antidepressant drugs; serotonin reuptake inhibitors; amphetamines used for attention-deficit hyperactivity disorder (adhd) * have a history of seizure.

Keywords: oxymorphone acute pain abdominal surgery opioids
evaluation of concordance between exhaled air test (ebam-cov) and rt-pcr to detect sars-cov-2

Conditions: SARS-CoV-2 Infection; COVID-19; Coronavirus

Summary: during the covid-19 pandemic, testing primarily relied on the use of nasopharyngeal swabs to detect the sars-cov-2 virus, responsible for the disease. however, this technique has several limitations, including the variable quality of swabs, its invasive nature, and arbitrariness in the choice of the number of cycles. furthermore, it does not allow for the detection of viral proteins. to overcome these limitations, researchers developed the ebam-cov test, patented for the detection of viral proteins in the exhaled air of covid-19 patients. this portable device provides an immediate assessment of the "viral load" with both quantitative and qualitative results, showing promise for early virus detection. the researchers hypothesize that the ebam-cov test is likely to exhibit a satisfactory concordance with the reference rt-pcr test in the detection of covid-19, especially among symptomatic patients or closed contacts.


Eligibility criteria:
inclusion criteria: * adult male or female patients over 18 years of age (≥) * suspected of being infected with covid-19 (symptomatic or contact case) and consulting for rt-pcr screening. exclusion criteria: * inability to understand the procedures to use the device * patient participating in an another interventional study * patient in exclusion period determined by another study * patient under court protection or guardianship * patient/trusted person/legal representative/family member for whom it is impossible to give informed information. * pregnant, parturient or breast-feeding patient

Keywords: diagnostic test kits
a study of mavacamten in non-obstructive hypertrophic cardiomyopathy

Conditions: Cardiomyopathy, Hypertrophic

Summary: the purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy (nhcm).


Eligibility criteria:
inclusion criteria * diagnosis of hcm consistent with current american college of cardiology foundation/american heart association and european society of cardiology guidelines: unexplained left-ventricular hypertrophy with non-dilated ventricular chambers in the absence of other cardiac or systemic disease which can produce the required magnitude of hypertrophy of a maximal left ventricular (lv) wall thickness ≥ 15 millimeters (mm) (or ≥ 13 mm with positive family history of hypertrophic cardiomyopathy \[hcm\]) as determined by core laboratory interpretation. * peak left ventricular outflow tract (lvot) pressure gradient \< 30 millimeters mercury (mm hg) at rest and \< 50 mm hg with provocation (valsalva maneuver and stress echocardiography). * new york heart association (nyha) class ii or iii. exclusion criteria * known infiltrative or storage disorder causing cardiac hypertrophy that mimics non-obstructive hypertrophic cardiomyopathy (nhcm) such as fabry disease, amyloidosis, or noonan syndrome with lv hypertrophy. * history of unexplained syncope within 6 months prior to screening. * history of sustained ventricular tachyarrhythmia (\> 30 seconds) within 6 months prior to screening. * other protocol-defined inclusion/exclusion criteria apply.

Keywords: mavacamten non-obstructive hcm non-obstructive hypertrophic cardiomyopathy (nhcm)
a multicenter randomized controlled study of the effect of laparoscopic preservation of the pylorus

Conditions: Quality of Life

Summary: for the patients with early gastric cancer (t1), preoperative evaluation (gastroscope, ultrasound gastroscope and abdominal enhanced ct) showed that the tumor was located in the body of the stomach, and the margin was enough to retain the pylorus and non lymph node metastasis (n0). lappg (d1 + lymph node dissection) and traditional laparoscopic distal gastrectomy (bii type anastomosis, d1 + lymph node dissection) were included a control study was conducted to evaluate the influence of two surgical methods on the long-term quality of life of patients after operation


Eligibility criteria:
inclusion criteria: 1. 18 years old \< age \< 75 years old; 2. primary gastric lesions were diagnosed as gastric adenocarcinoma by biopsy; 3. the preoperative clinical stage was t1n0m0 according to ajcc-7thtnm; 4. it is predicted that r0 can be obtained by pylorogastric gastrectomy and d1 + lymph node dissection; 5. preoperative ecog physical state score 0 / 1; 6. preoperative asa score i-iii; 7. informed consent of patients. exclusion criteria: 1. pregnant or lactating women; suffering from serious mental illness; 2. the history of upper abdominal surgery (except laparoscopic cholecystectomy); 3. history of gastric surgery (including esd / emr for gastric cancer); 4. preoperative imaging examination showed regional enlarged lymph nodes; 5. having other malignant diseases within 5 years; 6. patients with gastric cancer who have received new adjuvant therapy or recommended new adjuvant therapy; 7. there was a history of unstable angina or myocardial infarction within 6 months; 8. have a history of cerebral infarction or cerebral hemorrhage within 6 months; 9. there was a history of continuous systemic corticosteroid therapy within 1 month; 10. simultaneous surgical treatment of other diseases is needed; 11. gastric cancer with complications (hemorrhage, perforation, obstruction) requires emergency surgery; 12. fev1 of pulmonary function examination was less than 50% of the predicted value.
development of a new instrument to evaluate gait characteristics of individuals with duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy; Gait Disorders in Children; Gait Disorders, Neurologic

Summary: the aim of this study was to develop a gait assessment instrument for duchenne muscular dystrophy patients (dmd-gas), and investigate its validity and reliability.the scale was developed considering the expert opinions which included 10 physiotherapists who had experience in the management of patients with dmd over the 2-round delphi method, and the content validity index (cvi) was calculated. the final version of the dmd-gas that was agreed upon the experts consisted of 10 items, and each item scored between 0 and 2. the intra-rater reliability was established by the video analysis of children with a 1-month interval and inter-rater reliability was determined by the scores of 3 physiotherapists. the criterion validity was determined by investigating the relationship between the total score of the dmd-gas and motor function measure (mfm), 6 minute walk test (6mwt), and the data obtained from gaitrite system.


Eligibility criteria:
inclusion criteria: 1. being diagnosed with dmd 2. be between levels i-v according to brooke lower limb extremity functional classification 3. being between the ages of 5-18 4. agreeing to participate in the research voluntarily exclusion criteria: 1. insufficient cooperation with the physiotherapist, 2. have had any injury and/or surgery of the lower extremities in the last 6 months, 3. having neurological problems in addition to dmd. -

Keywords: duchenne muscular dystrophy gait pattern scale development reliability and validity gait analysis
physical therapy treatment on children and adolescents with neurological pathologies

Conditions: Neurologic Disorder; Duchenne; Pediatric Disorder; Sensorimotor Disorder Nos

Summary: to evaluate the positive effects of a home-based physical therapy intervention added to the usual physical therapy programs performed in children with neurological pathologies that induce sensorimotor impairments that affect their quality of life and the importance of the implications of their families in their treatment.


Eligibility criteria:
inclusion criteria: * parents agree to include their children on the study * affiliated to the duchenne parents project association (spain) * between 3-18 years old exclusion criteria: * other pathological conditions * parents refuse the participation on the study

Keywords: childhood neurologic disorder duchenne
cranberry proanthocyanidins for modification of intestinal e. coli flora and prevention of urinary tract infections in uti-susceptible women

Conditions: Urinary Tract Infection

Summary: the purpose of the research is to determine if eating sweetened, dried cranberries or strawberry fruit pieces will increase the types of different e. coli bacteria in the intestines which may reduce the likelihood of a major, or highly harmful urinary type of bacteria which cause urinary tract infections in susceptible women.

this is a research study about the number and types of bacteria that cause urinary tract infections (e. coli strains) that are present in the intestine. the bacteria will be collected and analyzed before and after eating either sweetened, dried cranberries or strawberry fruit pieces. this study will help us learn more about whether or not the components of consumed sweetened, dried cranberries or strawberry fruit pieces reduce the numbers of harmful e. coli bacteria in the vaginal and intestinal tracts, thereby reducing the number of urinary tract infections among women.

Eligibility criteria:
inclusion criteria: * women, ages 18-65 * history of recurrent urinary tract infections defined as three in the past year, or two in the last six months * subjects must be willing to follow the study protocol that includes consuming the mandatory daily dose of cranberries or strawberry fruit pieces and traveling to the uwhc urology clinic for scheduled rectal and vaginal swab procedures. the non-uti-susceptible group will include women ages 18-65 with no history of recurrent uti's as defined above. exclusion criteria: women who: * are pregnant * have an immune compromising disease * have diabetes * have kidney stones * have chronic bowel inflammatory disease * have known allergies to cranberries, strawberries, elderberries, or wheat fiber non-uti-susceptible group will include women ages 18-65 with no history of recurrent uti's as defined above.

Keywords: urinary tract infection uti
endothelial function and progenitor cells in acute ischemic stroke

Conditions: Ischemic Stroke

Summary: the purpose of this study is to determine whether levels of circulating endothelial progenitor cells (cepc) are increased in the acute phase of ischemic stroke.

endothelial dysfunction is a key component of atherosclerosis which contributes to the development of cardio- and cerebrovascular diseases. however, endothelial dysfunction (ed) is not established as a risk factor for ischemic stroke. as a novelty the proposed trial investigates the following variety of indirect markers of endothelial function in acute ischemic stroke: circulating endothelial progenitor cells (epc), endothelial microparticles (emp), endopat (rh- pat ratio) in two regards: 1. time after ischemic events (\< 48h, days 4-5, day 7 or at discharge) 2. etiological stroke subtypes it is not known whether these parameters are changed after acute cerebral ischemia and could possibly serve as specific target for treatment.

Eligibility criteria:
inclusion criteria: * patients with first ever ischemic stroke * tia, or transient symptoms with infarction (tsi) * age \> or = 18 years old within 24 hours after onset * written informed consent to participate * no evidence for dysphagia exclusion criteria: * malignant hematopoietic disease (e.g. leukemia), severe systemic infections, severe immunological disease, renal or hepatic failure * pancreatitis, cholecystolithiasis, intestinal malabsorption * lactose intolerance * increased risk of aspiration * pregnancy * life expectancy less than 12 months * inability to give written informed consent * psychosis * alcohol dependency * abuse of illegal drugs

Keywords: stroke cerebral infarction cerebrovascular disorders brain diseases central nervous system diseases
establishment and evaluation of prenatal prevention and treatment strategy for nards

Conditions: Acute Respiratory Distress Syndrome; Respiratory Distress Syndrome, Acute

Summary: 1. a predictive model for nards was established based on perinatal risk factors. multivariate logistic regression analysis was used to screen the independent prenatal risk factors for nards. a logistic regression model was constructed using the above independent risk factors and quantified in a nomogram to construct a visualization model for prenatal prediction of nards. 2. the role of acs in the prevention and treatment of ards in near-term/full-term infants. for neonates with a probability greater than 80% in the prediction model of ards, at least one acs was given before the termination of pregnancy. the gc level of cord blood (taken at birth) and the mrna levels of α-enac, na-k-atpase and sgk1 in nasal epithelium were measured within 2 hours and 1 day after birth in the acs intervention group and the control group. the occurrence and severity of pulmonary edema, the occurrence and severity of ards, and the mortality rate of nards were evaluated by lung ultrasound. the indexes of the two groups were compared horizontally and longitudinally.

based on the proposed scientific hypothesis, the project team intends to achieve the following research objectives through scientific experiments: to explore the role of acs in promoting fetal lung maturation from the perspective of lung fluid clearance through the traditional concept that acs promotes fetal lung maturation mainly by inducing ps, so as to further expand the object and scope of acs application. the prenatal prediction model of ards was established by using perinatal risk factors, and the predictive value was visualized. to explore the clinical value and mechanism of acs in pregnant women at high risk of nards, and to open up new ideas for the prevention and treatment of nards from the perspective of promoting lung fluid clearance; the early prevention and treatment strategy of nards was established by combining the "prenatal prediction model +acs", and its effect was evaluated.

Eligibility criteria:
a predictive model for neonatal acute respiratory distress syndrome was established based on perinatal risk factors. inclusion criteria: 1. the pregnant women with a probability greater than 80% in the prediction model of neonatal acute respiratory distress syndrome and agreed to acs intervention. 2. obtaining patient consent. exclusion criteria: 1. the pregnant women with a probability of less than 80% in the neonatal acute respiratory distress syndrome prediction model. 2. the patient refuses.

Keywords: neonatal acute respiratory distress syndrome prediction nomogram antenatal corticosteroids
study of effects of electroacupuncture on balance in subjects with chronic functional ankle instability

Conditions: Ankle Sprain

Summary: introduction: ankle sprains, the most common sports-related musculoskeletal injury, account for approximately 25% of sports injuries. an estimated 40% of these individuals will progress to develop chronic functional ankle instability (cfai), which can significantly affect athletic performance and activities of daily life. stresses from the injury can damage the ligaments, muscles, nerves and mechanoreceptors. it is widely accepted that ankle proprioception is critical for balance and that individuals with cfai demonstrate decreased proprioception and altered muscular function, which impairs postural stability. the goal of this study is to determine if a single application of electroacupuncture can have an immediate positive outcome related to balance in individuals with cfai. methods: this single blinded randomized trial will include 12 subjects receiving a single application of electroacupuncture and 12 subjects in the placebo group receiving sham electroacupuncture. subjects aged 18-50 with a history of unilateral inversion ankle sprain(s) and chronic symptoms of instability will be selected. balance will be assessed pre- and post-treatment using force plate data during a single-leg stance and via the star excursion balance test (sebt). gb-34 and gb-40 will be used for the experimental group and non-traditional points on the medial aspect of the leg will be used for the sham electroacupuncture group. both will be connected to the electrical stimulation unit for 10 minutes. results from this study may inform future research investigating the ability of ea at decreasing the risk of ankle sprains, improving perceived stability, and reducing the risk of subsequent degenerative changes.

a single application of electroacupuncture improves balance greater than placebo control in subjects with chronic functional ankle instability specific aim #1: evaluate the effect of a single application of electroacupuncture on center of pressure mean total velocity in individuals with chronic functional ankle instability during single-leg stance compared to placebo control. h0: ea will not improve postural sway during single-leg stance compared to placebo control. specific aim #2: describe the effects of a single application of ea compared to placebo on mean total displacement, as well as the mediolateral and anterioposterior components during single-leg stance for possible trends to inform hypothesis generation. specific aim #3: correlate the results from the star excursion balance test with results of the single-leg stance measures to inform hypothesis generation.

Eligibility criteria:
inclusion criteria: * age 18-50 years old * history of inversion ankle sprains * chronic symptoms of instability exclusion criteria: * please see inclusion criteria
a study comparing cardiovascular effects of ticagrelor versus placebo in patients with type 2 diabetes mellitus

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to compare the effect of ticagrelor versus placebo in patients with type 2 diabetes mellitus.

a multinational, randomised, double-blind, placebo-controlled phase iiib trial to evaluate the effect of ticagrelor twice daily on the incidence of cardiovascular death, myocardial infarction or stroke in patients with type 2 diabetes mellitus

Eligibility criteria:
inclusion criteria: men or women ≥50 years of age with type 2 diabetes mellitus on treatment with a glucose lowering medication since at least 6 months, and either documented coronary artery occlusive disease or previous revascularization of a coronary artery. key exclusion criteria: history of myocardial infarction or any stroke; planned treatment with agents inhibiting blood clotting; planned use of asa/aspirin at doses above 150 mg daily; planned coronary, cerebrovascular, or peripheral arterial revascularization; patients with known bleeding disorders and patients who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin; history of intracranial bleeding at any time, or a history of bleeding from the gastrointestinal tract within the last 6 months or a major surgery within the last 30 days; patients with known severe liver disease or with kidney failure requiring dialysis

Keywords: diabetes coronary artery disease outcome prevention antiplatelet
education program for burn patients

Conditions: Burns

Summary: the purpose of this study is to assess the effect of an educative program including telephone follow-up for burn patients regarding the impact of this intervention on the health status and return to work at six months after hospital discharge.


Eligibility criteria:
inclusion criteria: * adult burned patients (18 years or older), male and female * patients burned for the first time who needed hospitalization at the burns unit * in cognitive conditions to participate (being able to tell one's address, day of the week and age or birth date) * in physical conditions to accomplish self-care. exclusion criteria: * participants burned due to suicide or with previous psychiatric diagnoses or cognitive and psychological difficulties that do not allow them to answer the instrument questions and take care of themselves.

Keywords: burns rehabilitation