Kornimate/medical-research-clean huggingface dataset:
fluid administration limited by lung ultrasonography in the operating room: correlation to stroke volume variation.

Conditions: Surgery

Summary: the possibility of exploring the lungs by lung ultrasound, a non-invasive tool, is becoming increasingly popular for anesthesiologists. recently, lichtenstein has described the falls protocol (fluid administration limited by lung sonography) which uses the potential of pulmonary ultrasound to evaluate early pulmonary overload due to fluid administration at a subclinical stage. indeed, fluid administration can generate a sub-clinical interstitial syndrome that can be detected by passing from a profile a to a profile b in lung ultrasound. the transition from a profile a to a profile b therefore corresponds to the transition from a state of preload dependent to a state of preload independence. however, this tool has not been studied in the operating room. the main objective of this study will be to study the correlation between pulmonary ultrasound and sv variation measured by esophageal doppler during fluid administration in patients with haemodynamic optimisation in the operating room during digestive, urological, gynecological and orthopedic surgeries. the main expected result is the following: good correlation between the absence of increased sv in the esophageal doppler and the appearance of a b-profile lung ultrasound fluid administration in the operating room.


Eligibility criteria:
inclusion criteria: * age ≥ 18 ans * inclusion criteria: * patient having a digestive, urological, gynecological, vascular or orthopedic surgery * haemodynamic optimisation requiring titration of the fluid administration * informed consent signed exclusion criteria: * non-consent * chronic pulmonary pathology: copd with pulmonary emphysema, pulmonary fibrosis

Keywords: lung ultrasonography fluid administration limitation stroke volume variation esophageal doppler
weekly zinc chelate supplementation on children's growth

Conditions: Short Stature

Summary: the purpose of this study is to measure the effect of weekly zinc supplementation on schoolchildren with growth deficit or normal stature.

zinc is an important micronutrient for humans. trials with zinc have shown positive effects of supplementation on growth, but there is still a lack of results on schoolchildren population. this randomized double-blind controlled trial was design to measure the effect of weekly zinc supplementation on schoolchildren with growth deficit and normal stature. schoolchildren were allocated into two homogeneous groups named growth deficit (haz \< -1,5 z-score), and normal stature (haz between -1,0 and ±1,0 z-score) and were randomly assigned to compose two exposed and two control groups to receive a supplement of 30mg of zinc amino acid chelate or placebo individually once a week, during 12 weeks. children's heights were measured at the end of supplementation period and again after 12 weeks.

Eligibility criteria:
inclusion criteria: * children with one and a half or more standard deviations below the mean height for age and gender of the reference population (z-score under -1.6) were included in the growth deficit group (gd). for the normal stature group(ns), haz was set up as being between -1 and +1 standard deviations from the mean height reference for age and sex. exclusion criteria: * children of gd group were evaluated by a pediatrician specialized in growth disorders with the objective of excluding any organic or genetic condition correlated with growth deficit.

Keywords: zinc growth child dietary supplements randomized controlled trial
fear of hypoglycemia and glycemic variability

Conditions: Type 1 Diabetes

Summary: subjects with type 1 diabetes are invited to provide usual blood glucose monitoring and a blood glucose profile (pre/ post prandial blood glucose + night blood glucose) on 3 occasions in a 2 week time period, in addition to the filling of 5 questionnaires including fear of hypoglycemia-2 questionnaire.

subjects with type 1 diabetes are invited to provide usual blood glucose monitoring and a blood glucose profile (pre/ post prandial blood glucose + night blood glucose) on 3 occasions in a 2 week time period, in addition to the filling of questionnaires including fear of hypoglycemia-2 questionnaire. biobanking of urine/blood collection of key medical informations by investigators questionnaires : * socio-economic status * fear of hypoglycemia-2 * anxiety depression scale (had) * health survey (sf36, sf12) * satisfaction to treatment (dhp-18) * dutch eating behavior questionnaire (debq) * pittsburgh quality of sleep (psqi) * blood glucose diary

Eligibility criteria:
inclusion criteria : * type 1 diabetes * at least 2 blood glucose monitoring daily * on insulin for more than 5 years exclusion criteria : * not stable metabolic condition (infection, steroid therapy) * below 3 months change in insulin treatment * other clinical trial * renal failure (edfg below 30 ml/min/1.73 m²) * pregnancy and/or lactation

Keywords: diabetes
promoting immune health by intermittent fasting: a pilot study

Conditions: Metabolic Syndrome; HEALTHY VOLUNTEERS; Time Restricted Feeding; Insulin Resistance; Inflammation

Summary: the goal is to study the direct effects of long-term intermittent fasting on immune cell populations in the blood, combined with analyses of systemic metabolic fitness and inflammatory activation of leukocytes.

the investigators aim to investigate the direct effects of intermittent fasting on the molecular characteristics of monocytes and their related health benefits. in addition,the investigators want to assess the post-prandial inflammation and the potential protective role of if on post-prandial monocyte activation and its related health benefits. this pilot study may better understand the molecular mechanisms behind if, which could further personalize lifestyle guidance and identify novel anti-inflammatory processes that control immune responses and inflammation.

Eligibility criteria:
inclusion criteria metsyn: * bmi 30 to 43 kg/m2 * homa-ir index larger/same as 2.5 * and at least 3 out of 5 ncep (national cholesterol education program) metabolic syndrome criteria: * fasting plasma glucose ≥ 6.1 mmol/l, * triglycerides≥1.7mmol/l, * waist-circumference\>102cm, * hdl-cholesterol\<1.04mmol/l, * bloodpressure≥130/85mmhg). inclusion healthy volunteers * body mass index (bmi) 18 to 25 kg/m2, * waist circumference between 79 cm and 94 cm and * homa-ir index: ≤ 2.0 (measured as fasting insulin (pmol/l) x fasting glucose (mmol/l)) / 135) exclusion criteria; (all) * excessive weight loss of \>10% in the last months; * use of any medication, including proton pomp inhibitors and antibiotics in the past three months; * cholecystectomy; * untreated gi disease/abnormal bowel habits; * plasma aspartate aminotransferase and alanine aminotransferase are 2.5 times or more the upper limit of the normal range; * a history of cardiovascular event (mi or pacemaker implantation); * a history of heavy alcohol use (\>12 to 15 g of alcohol per day, or \>12 oz of beer, 5 oz of wine, or 1.5 oz of distilled spirits); * a dependency on alcohol or unable to pause the consumption of alcohol during the study period. * an (expected) prolonged compromised immunity (due to recent cytotoxic chemotherapy or hiv infection with a cd4 count \< 240); * unmotivated or not able to adhere to a specific diet; * history of eating disorder; * night workers or people with deviant day/night rhythm; * pregnant, trying to get pregnant or breast feeding at inclusion; * irregular menstrual cycle; * hormonal replacement therapy (other than oral contraceptives).
serum tenascin-c concentration in patients with acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: this study valuates the serum tenascin-c concentration in patients with acute coronary syndrome.

it is found that tenascin-c plays an important role in ventricular remodeling, heart failure, aortic dissection, rheumatic heart disease and other cardiovascular diseases, which may be a new marker for the diagnosis and prognosis prediction of these diseases. however, there is few relevant studies about the tenascin-c concentration in patients with acute coronary syndrome.this study valuates the serum tenascin-c concentration in patients with acute coronary syndrome.

Eligibility criteria:
inclusion criteria: .diagnosed as acute coronary syndrome,including stemi,non-stemi,and uap. * with left ventricular ejection fraction（lvef）\>=45% * written informed consents are obtained * admitted within 24 hours after chest pain attacked exclusion criteria: * complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy * complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction * with acute or chronic infection, surgery or trauma in the last month * secondary hypertension, severe liver dysfunction,severe renal insufficiency * with abnormal thyroid function or allergy to iodine agent * refusal to sign the informed consent

Keywords: tenascin-c
glycemic variability, gut microbiota, and prognosis in t2dm with acs

Conditions: Type 2 Diabetes Mellitus; Coronary Heart Disease

Summary: patients with type 2 diabetes mellitus (t2dm) diagnosed with acute coronary syndrome (acs) by coronary angiography in the second affiliated hospital of nanchang university were consecutively included in a prospective cohort study. during the acute phase of acs, blood glucose was monitored using a continuous glucose monitoring system (cgm) for 14 days, and for patients who had been hospitalised for less than 14 days, they continued to wear the cgm for monitoring blood glucose until 14 days after discharge. during this period, stool and serum samples were analysed for multi-omics (16s rrna sequencing and metabolomics). subsequently, a follow-up period of at least 1 year was performed to observe the patients for the occurrence of adverse cardiovascular events (mace) during the follow-up period and to assess the impact of glycaemic variability and gut flora and its metabolites on the prognosis of patients with t2dm combined with acs.


Eligibility criteria:
inclusion criteria: clinical diagnosis of type 2 diabetes mellitus (t2dm). clinical diagnosis of acute coronary syndrome (acs). exclusion criteria: history of hemodialysis. recent antibiotic use within the past two weeks. active malignant tumors. pregnancy and breastfeeding. inability to wear sensors due to severe skin conditions. coagulation disorders, anemia, or abnormal hematocrit levels. requirement for mri during the sensor-wearing period. inability to follow study instructions or deemed unsuitable for the trial by the treating clinician/nurse. inability to understand informed consent or communicate with researchers due to cognitive decline or mental illness.

Keywords: gut microbiome type 2 diabetes mellitus coronary heart disease glycemic variability
cerebral oxygenation to guide medical interventions in extremely preterm infants

Conditions: Premature Infants; Near-infrared Spectroscopy; Oximetry

Summary: regional tissue oxygenation (rsto2) can be monitored by near-infrared spectroscopy. the investigators planned a safeboosc phase ii trial to test if a reduction of the burden of hyper- and hypoxia can be accomplished during the first three days of life in infants born before 28 completed weeks of gestation. the investigators developed a treatment guideline and a randomised trial design to evaluate if cerebral rsto2 spent out of range in %hours can be reduced by 50%. the present trial is a non-randomised pilot study of the intervention in 10 infants.


Eligibility criteria:
inclusion criteria: * gestational age at birth less than 28 completed weeks * cerebral oximeter in place at 3 hours after birth exclusion criteria: * decision not to provide full life support
efficacy and safety of metamizole versus placebo as antithermic therapy in the acute phase of ischemic stroke

Conditions: Stroke

Summary: clinical efficacy and safety of metamizole 2 g i.v. versus placebo, as antithermic therapy in the acute phase of ischemic stroke.


Eligibility criteria:
inclusion criteria: * age over 18 years * hemispherical cerebral infarction with moderate (sss = 30-44 points) or severe (sss \< 30 points) deficit at the time of inclusion. however, only patients with a score between 15 and 44 points on the sss scale will be included * tympanic temperature between 37 and 38 degrees celsius. the relationship between tympanic and body temperature is as follows: tympanic temperature = body temperature + 0.3 degrees celsius * onset of cerebral infarction symptoms within the last 24 hours. when the time of onset of symptoms is unknown (e.g. ictus occurred while sleeping) the last time when the patient was asymptomatic will be considered as time of onset * normal cerebral ct scan or with signs of cerebral infarction * patient's written or orally witnessed informed consent in accordance with local legislation, guidelines of good clinical practice (gcp) and international conference on harmonization (ich)-gcp exclusion criteria: * patients with a history of granulocytopenia, thrombocytopenia or aplastic blood diseases of any etiology. known hypersensitivity to salicylates, pyrazolones and other nonsteroidal antiinflammatory drugs (nsaids). nsaid-induced bronchial asthma * patients with a history indicating a life expectancy less than 30 days or patients whom the investigator thinks that it will not be possible to follow for entire 30 days * non-cooperative * patients with neurological sequelae of a previous stroke * cerebral hemorrhage * pregnancy, lactation * participation in another clinical trial * intake of acetylsalicylic acid (asa) \> 300 mg per day, paracetamol or nsaids during the 24 hours prior to administration of the study medication * seizures at the start of the stroke
exercise and treatment-as-usual in substance use treatment outcomes

Conditions: Substance-Related Disorders

Summary: the research study compares the substance abuse treatment outcomes (e.g., craving, withdrawal symptoms, rates of use, abstinence) of standard intensive outpatient care, with or without an added 6-wk aerobic exercise component. in addition, certain biomarkers associated with both exercise and substance use (e.g., endocannabinoids and cortisol) will be assessed. in a rolling admissions format over the course of a year, approximately 36 treatment-seeking substance users who are currently receiving intensive outpatient treatment through a local alcohol or other drug abuse agency will be randomized to either receive 6 weeks aerobic exercise training in addition to standard care or standard care with 6 weekly laboratory visits to complete questionnaires (18 per group).


Eligibility criteria:
inclusion criteria: * intact cognitive status and ability to provide informed consent * ability to read and write in english sufficient to provide consent and complete study questionnaires * current diagnosis of a single or of multiple substance use disorders * currently enrolled in an intensive outpatient treatment substance use program * desire to quit and to seek treatment for substance use * currently sedentary, not participating in any formal/structured exercise program exclusion criteria: * a history or present diagnosis of severe depression, psychotic, or bipolar disorder * presence of cardiac disease or any other medical condition that would make engaging in exercise unsafe * undergoing methadone treatment * chronic conditions such as cancer, diabetes, kidney disease, or autoimmune disorders * women who are pregnant or planning to become pregnant
virtual reality in the rehabilitation in patients with lower limb amputation.

Conditions: Amputation; Lower Limb; Rehabilitation; Activities of Daily Living; Virtual Reality; Lower Extremity

Summary: the goal of this clinical trial is to test the impact of virtual reality on rehabilitation for the patients after a major amputation. the main questions it aims to answer are: * does the virtual-reality-assisted rehabilitation improve the life quality of patients (i.e. lesser pain, better spirit)? * does the virtual-reality-assisted rehabilitation improve the daily life function of the patients? participants will received a virtual-reality-assisted rehabilitation on the second postoperative day for ten days. the rehabilitation would be carried out two times per day and 30 minutes per training.

despite the increasing development of revascularisation techniques, lower limb amputation often represent the last chance of survival for the vasculopathic patient with chronic limb threatening ischemia (clti). first goal after lower limb amputation is represented by a rapid prosthesis application. the patient in the immediate post-operative period must undergo intensive rehabilitation and physiotherapy, which involves not only a physical but also a psychological approach. "classical" recovery following lower limb amputation includes adequate pain therapy and physiotherapy to regain independence, strength, mobility and finally prothesis application to improve quality of life and restore mobility. the aim of this study is to investigate the effect of adding virtual reality to traditional rehabilitation following a lower limb amputation in patients due to limited circulation, with particularly attention to a possible improvement of psychological state, reduction of post-operative pain and more rapid improvement in regaining functional mobility

Eligibility criteria:
inclusion criteria: * \> 18 years * critical limb ischemia or acute limb ischemia * amputation above/below knee * unilateral lower limb amputees exclusion criteria: * physical disability (paralysis, plegia) * inability to give informed consent * neurological or psychiatric problem that reduces compliance * loss of planned post-operative assessments * traumatic amputation in a patient without circulatory disorders

Keywords: amputation lower extremity ischemia lower limb lower limb ischemia rehabilitation activities of daily living virtual reality lower limb amputation knee lower limb amputation above knee lower limb amputation below knee lower extremity wound
prevalence of intestinal parasitic infections in under-five children with malnutrition in sohag, egypt

Conditions: Malnutrition, Child

Summary: this study aims to estimate the prevalence of intestinal parasitic infections in under-five children with malnutrition.

malnourished children are vulnerable to ipis suffering. in contrast, ipis can contribute considerably to the evolution of undernutrition in the pediatric population, thus creating a potentially lethal cycle/vicious cycle of worsening illness and deteriorating nutritional status so, i will examine stool specimens of those children suffering from malnutrition. one fecal sample will be collected from each patient in a labelled clean plastic container. specimens will be immediately transferred to the medical parasitology department laboratory the obtained fecal samples will be both macroscopically and microscopically examined. for microscopic examination, specimens will be examined by direct smear and fect. anthropometric indices will be used for checking the nutritional status of the recruited children.

Eligibility criteria:
inclusion criteria: - 100 children aged between 6 months and 5 years, having malnutrition symptoms (growth retardation, failure to thrive, lethargy, generalized weakness, xerophthalmia, etc.) will be randomly recruited from pediatric outpatient clinics, faculty of medicine, sohag university. exclusion criteria: * children who took specific anthelmintic, antiprotozoal, purgatives or anti-diarrheal drugs three weeks before the stool sampling.
prevention of ulnar collateral ligament (ucl) injuries in minor league pitchers

Conditions: Elbow Injuries; Sprain Ulnar Collateral Ligament; Upper Extremity Injuries; Strain of Ulnar Collateral Ligament; Complete Tear Ulnar Collateral Ligament

Summary: this is a study of the muscle stabilizers of the elbow with respect to the prevention of ulnar collateral ligament (ucl) injuries in pitchers. pitchers are assessed at spring training and end of season for approximately 5 years. pronator, flexor digitoum superficialis (fds), and wrist flexion strength will be measured and correlated with upper extremity injuries and time missed from pitching. the investigators will also be measuring loss of strength over the season. the goal is to learn whether strength in these muscles prevents ucl injuries and finally whether these muscles can be strengthened to avoid such injuries.

the goal of this study is to assess whether the strengths of the secondary muscular stabilizers toward valgus stress at the elbow, the wrist flexors, flexor digitorum superficialis, and pronator teres emanating from the medial epicondyle, affect the incidence of ulnar collateral ligament injuries of the elbows in pitchers. pitchers in the minor leagues of a single professional baseball club will have the strength of these secondary muscular stabilizers assessed and then correlated to ulnar collateral ligament injuries and time missed from baseball season and subsequent seasons. a secondary goal is to assess whether strengthening exercises targeted toward these muscular stabilizers of the elbow can decrease the incidence of ulnar collateral ligament injuries in young baseball pitchers. this could impact the field by changing the emphasis from reconstruction and rehabilitation of ulnar collateral ligament injuries to prevention.

Eligibility criteria:
inclusion criteria: * pitchers that are currently on a minor league baseball team. exclusion criteria: * pitchers that currently have upper extremity injuries or are in active rehab for upper extremity injury.

Keywords: ulnar collateral ligament elbow injuries dynamic elbow stabilizers tommy john's procedure elbow injuries in pitchers
the effect of oxytocin on the gastric emptying

Conditions: Postprocedural Delayed Gastric Emptying

Summary: the investigators are going to examine whether oxytocin has a prokinetic effect on gastric emptying in patients suffering from gastro paresis. oxytocin infusion will be compared with sodium chloride infusion.

the investigators are going to examine whether oxytocin has a prokinetic effect on gastric emptying in patients suffering from gastro paresis. oxytocin infusion will be compared with sodium chloride infusion.the gastric emptying is estimade by sitntigraphy during 70 minutes, and performed twicw. once with saline and once with oxytocin.

Eligibility criteria:
inclusion criteria: * gastroparesis in diabetics exclusion criteria: * treatment with other prokinetics, other severe organic or psychological diseases

Keywords: oxytocin gastroparesis diabetics the effect of oxytocin on gastric emptying