Kornimate/medical-research-clean huggingface dataset:
yoga nidra and pain after caesarean section

Conditions: Caesarean Section; Yoga

Summary: the effect of yoga nidra on pain, mobilisation, first walking distance and maternal satisfaction after caesarean section

the aim of this study is to investigate the effect of yoga nidra on pain, mobilisation, first walking distance and maternal satisfaction after caesarean section. sample size: * the sample size is 128 women. * the sample will include 64 mothers in the experimental group and 64 mothers in the control group. application time: * yoga nidra will be performed once in the sixth postoperative hour after caesarean section. * yoga nidra will be carried out once for each mother by the researcher ayşegül kılıçlı. * the application will take 30 minutes. * only yoga nidra will not be applied to the control group. other measurements and follow-ups will be carried out in parallel as in the experimental group. data collection tools: * introductory information form * visual analogue scale for pain * patient mobility scale and observer mobility scale * newcastle satisfaction with nursing care scale * note: mobilisation distance will be measured with a metre. measurement time: * introductory information form will be filled out before application. * pain level will be measured immediately before the application. * immediately after the application pain, mobilisation, first walking distance and maternal satisfaction will be measured.

Eligibility criteria:
inclusion criteria: * women who gave birth by caesarean section, * whose birth was performed with spinal anaesthesia, * who are 19 years of age or older and 35 years of age or younger, * who were born at 37 or more weeks of gestation, * who had a singleton birth, * who do not have chronic diseases and any complications in this pregnancy and postpartum period, * who have not performed yoga nidra practice before will be included in the study. exclusion criteria: * those who do not meet the inclusion criteria of the study, * who do not voluntarily participate in the study, * those who want to voluntarily leave the study at any stage after being included in the study, * mothers who develop any health problems in the birth and postpartum period will be excluded.

Keywords: caesarean section yoga nidra pain mobilization
dexmedetomidine versus lidocaine infusions as adjuvants to general anesthesia for chronic pain management after mastectomy

Conditions: Dexmedetomidine; Lidocaine; Infusion; Adjuvants; General Anesthesia; Chronic Pain; Mastectomy

Summary: this study aims to compare dexmedetomidine and lidocaine infusions as adjuvants to general anesthesia for chronic pain management after mastectomy.

chronic pain after breast cancer surgery is a significant problem that is expected to become more relevant because the number of patients undergoing breast cancer surgery is increasing owing to the longer survival associated with this surgery. lidocaine is the local anesthetic, which is used more often, and it is considered the prototype of amino-amide local anesthetics. dexmedetomidine (dex) is a highly selective agonist that acts by binding with presynaptic alpha 2-adrenergic receptor and then activating the negative feedback loop of the sympathetic nerve response, leading to inhibited norepinephrine release from the sympathetic terminals and decreased reflex activity of the sympathetic nervous.

Eligibility criteria:
inclusion criteria: * age from 18 to 75 years. * american society of anesthesiologists (asa) physical status ii. * scheduled for mastectomy with axillary dissection (either modified radical mastectomy with or without latissimus dorsi flap or conservative breast surgery) due to breast cancer. exclusion criteria: * patient refusal. * known allergy to any of the study drugs. * those with hepatic or renal insufficiency. * patients who are running regularly on b blockers. * α2 adrenergic agonists and sedatives. * psychoactive medications.
exercise prescription for the improvement of quality of life in elderly patients with multiple myeloma

Conditions: Plasma Cell Myeloma

Summary: this trial studies how well exercise prescription works in improving quality of life in elderly patients with multiple myeloma. engaging and adhering to an exercise program may improve functional status and quality of life and decrease pain and skeletal-related events. this study is being done to see if elderly patients with multiple myeloma can participate in a physical activity program.

primary objective: i. assess the ability for elderly multiple myeloma patients to maintain a personalized exercise regimen and activity level for a period of 6 months. secondary objective: i. assess changes in biometric data. exploratory objective i. evaluate changes in bone metabolism markers as a result of exercise. outline: patients meet with a physical therapist on day 0 and at 3 and 6 months and receive a personalized home exercise intervention consisting of aerobic and resistance training for 6 months. patients also receive face-to-face sessions, video chats, or text message check-ins with physical therapist weekly for 6 weeks and then every other week for up to 24 weeks. after completion of study, patients are followed up every 6 months for 5 years.

Eligibility criteria:
inclusion criteria: * diagnosis of multiple myeloma * if patients are undergoing an autologous stem cell transplant, then they will be enrolled after their transplant so that there is not an interruption in the study period * patients are eligible whether or not they have lytic bone lesions * if they do have lytic lesions, the lesions must be low risk for fracture (low risk by mirel's score or less than 50% of vertebral body height) * if patients are high risk for bone fracture, they must undergo bone stabilization prior to being considered for enrollment * patients will have to be at least 6 weeks from date of stabilization * provide signed and dated informed consent form * willing to comply with all study procedures and be available for the duration of the study * subjects need to be within 24 months of their multiple myeloma diagnosis * subject must be able to stand and walk to perform baseline assessments * subjects must be able to text message (will need cell phone) * need to limit to able to read and understand english as video visit capability is only in english at this point in time and multiple questionnaires will not be translated into other languages exclusion criteria: * presence of lytic lesions that cannot undergo appropriate stabilization * anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study * non english speaking * diagnosed greater than 24 months prior to screening
metformin for treatment of antipsychotic-induced dyslipidemia

Conditions: Dyslipidemia

Summary: almost all antipsychotics can induce dyslipidemia, but no treatment has been established. metformin can improve lipid levels in obese patients. the investigators conducted a randomized, placebo-controlled study to test the efficacy of metformin for antipsychotic-induced dyslipidemia.

the study was designed as a double-blind randomized controlled trial, with research assessors and patients intended to be blind to the intervention status. the staff members performing the assessment were not involved in implementing any aspect of the intervention.162 patients were randomized to one of two 24-week individual treatments: metformin (1000mg/day)or placebo. medications were provided in double-blind fashion.the assessments include lipid levels, body weight, body mass index, fasting glucose, fasting insulin and insulin resistance index.

Eligibility criteria:
inclusion criteria: diagnostic and statistical manual of mental disorder-fourth edition (dsm-ⅳ) criteria for schizophrenia dyslipidemia after antipsycotic treatment the duration of illness was less than 12 months taking only one antipsychotic stable outpatient the total score of positive and negative syndrome scale (panss)≤60. - exclusion criteria: liver or renal diseases pregnant or lactating women cardiovascular diseases hypertension or diabetes mellitus

Keywords: schizophrenia; dyslipidemia
effect of increased oxygenation in the air during endurance training in stable angina pectoris patients

Conditions: Angina Pectoris

Summary: the study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable angina pectoris patients, compared to training without extra oxygen supplementation. in addition work economy, stroke volume and cardiac perfusion is measured. the hypothesis of the study is that increased oxygenation of the air increases performance, stroke volume, work economy and cardiac perfusion.


Eligibility criteria:
inclusion criteria: * stable angina pectoris age 18-75 exclusion criteria: * unstable angina pectoris * limitations to exercise other than coronary artery disease * participants in other study interventions

Keywords: angina pectoris hyperoxia endurance training stroke volume cardiac perfusion
comparison of gamma nail versus dynamic hip screw for the treatment of unstable intertrochanteric fractures

Conditions: Intertrochanteric Femoral Fractures

Summary: the objective of the study is to examine the treatment of unstable intertrochanteric fractures with the short gamma nail, compared to the use of the dynamic hip screw (dhs). this is a prospective study. sixty patients with unstable intertrochanteric fractures will be randomized to be treated using either gamma nail or dhs. the patients will be followed for 12 months. the primary endpoint is the clinical outcome as measured by the merle d'aubigne and postelhip score.


Eligibility criteria:
inclusion criteria: * acute intertrochanteric fracture - a1-32 ao/ota * abbreviated mental score \>6 * community ambulator (pre-fracture state) exclusion criteria: * previous arthritis * pathological fracture * chronic corticosteroid use * concomitant lower extremity fractures

Keywords: intertrochanteric femoral fractures - unstable
correlation between oocyte and embryo mechanical properties on embryo development and clinical pregnancy after in vitro fertilization

Conditions: Infertility; Pregnancy, Multiple

Summary: the purpose of this study is to determine whether oocyte and embryo mechanical properties measured during in vitro fertilization can predict embryo development outcomes and clinical pregnancy.

in the current practice of in vitro fertilization (ivf), clinicians often transfer multiple embryos to the patient at once in an effort to maximize chances of pregnancy. this practice results in a high rate of multiple births which increase the risks of complications for mothers and children. the investigators in this study have developed a novel, noninvasive marker of embryo viability which is based on measuring embryo mechanical properties at the oocyte or the 1-cell stage. the investigators would like to test whether human oocyte or embryo mechanical properties are predictive of subsequent development, clinical pregnancy, and compare their predictive power to that of a morphological assessment (the current gold standard). using this approach, clinicians could more confidently move toward single embryo transfer, provided more individualized counseling for patients undergoing oocyte cryopreservation, as well as improve pregnancy rates after ivf. this is a pilot observational study. although investigators will measure the mechanical properties of all participant oocytes and embryos, no prediction of embryo viability will be made, and there will be no intervention in choosing which embryos to transfer to participants. the data from this study will eventually be used to find a range of oocyte and embryo mechanical parameters which are predictive of high developmental potential, and will serve as the basis for an interventional study in the future.

Eligibility criteria:
inclusion criteria: * between the ages of 21 and 45 * undergoing intra-cytoplasmic sperm injection (icsi) at stanford fertility, shenzhen ivf clinic, or taiwan ivf group between august 2015 and august 2018 exclusion criteria: * using gestational carrier or donor eggs * using cryopreserved eggs * fewer than 5 oocytes collected

Keywords: embryo in vitro fertilization ivf
reduced intensity total body irradiation + thymoglobulin followed by allogeneic pbsct

Conditions: Non-Hodgkin's Lymphoma; Leukemia; Multiple Myeloma; Acute Myeloid Leukemia; Hodgkin Lymphoma; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Myelodysplastic Syndrome

Summary: one of two different doses of thymoglobulin will allow bone marrow engraftment with minimal graft-versus-host disease and allow adequate immune response to allow the transplanted stem cells to replace the tumor cells.

this randomized phase ii trial studies how well giving low dose total-body irradiation (tbi) with anti-thymocyte globulin followed by donor peripheral blood stem cell transplant (pbsct) works in treating patients with hematologic malignancies. giving reduced intensity total-body irradiation and anti-thymocyte globulin before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. it may also stop the patient's immune system from rejecting the donor's stem cells. when the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. giving total-body irradiation together with antithymocyte globulin before transplant may stop this from happening.

Eligibility criteria:
inclusion criteria: * patients with hematological malignancies for which allogeneic stem cell transplantation indicated including non-hodgkin lymphoma (nhl), multiple myeloma (mm), acute myeloid leukemia (aml), hodgkin lymphoma (hd), chronic lymphocytic leukemia (cll), chronic myelogenous leukemia (cml), and myelodysplastic syndrome (mds) * patients with hla compatible related or unrelated stem cell donor, willing and able to serve as an allogenic hsc donor. unrelated donors have to be matched at hla-a, b, c and drb1 loci. a single locus mismatch will be tolerated in the event a more closely matched donor is not available. * patients age \>/=40 to \</=70 with an ecog performance status \< 2 * patients between 18 and 40 years of age will be eligible only if they have co-morbidities precluding conventional allogeneic transplantation with full intensity myeloablative conditioning * adequate cardiac, pulmonary, renal and hepatic function for transplant * negative serology for hiv * negative serum pregnancy test * patients who have received therapeutic radiation to a localized field will be eligible, provided critical structure tolerance doses have not been exceeded * patients who have had prior myeloablative autologous transplant will be eligible exclusion criteria: * evidence of uncontrolled viral, fungal, bacterial infection * evidence of active meningeal or cns disease * prior therapy with rabbit atg, prior treatment with equine atg is allowed if more than 3 months ago * breast feeding mothers are excluded

Keywords: total body irradiation allogeneic peripheral blood stem cell transplantation thymoglobulin
toric orthokeratology - slowing eye elongation

Conditions: Myopia; Astigmatism

Summary: the aims of this study are to investigate the effects of ortho-k for astigmatic and myopic reduction and myopic control in children, and the long term effects on corneal curvatures and biomechanics.

ortho-k has been shown to be effective in correcting low myopia but relatively ineffective for astigmatism, using spherical reverse geometry lens designs. toric ortho-k lenses have been introduced in recent years but the efficacy for astigmatic reduction and for myopic control in children have not been confirmed. the mechanism of myopic reduction in ortho-k cannot be fully explained by changes to the anterior corneal curvatures. it is therefore possible that other corneal parameters such as posterior corneal curvature and corneal biomechanics may contribute to the mechanism. the current study aims at investigating the efficacy of toric ortho-k lenses for correcting myopic astigmatism and for retarding myopic progression in children compared to children wearing single-vision spectacles. long term changes to other corneal parameters such as posterior cornea curvatures, topographical corneal thickness, corneal hysteresis, corneal resistance factor, with and without ortho-k lens wear will also be investigated.

Eligibility criteria:
inclusion criteria: * myopia (refractive sphere): more than -0.50ds to -5.00ds * astigmatism: with-the-rule astigmatism more than -1.25dc * anisometropia: ≤ 1.50d in both refractive sphere * best corrected monocular visual acuity: equal to or better than 0.10 in logmar scale in both eyes * availability for follow-up for at least 2 years exclusion criteria: * strabismus at distance or near * contraindication for contact lens wear and orthokeratology (e.g. limbus to limbus corneal cylinder and dislocated corneal apex * prior experience with the use of rigid lenses (including orthokeratology) * prior experience with myopia control treatment (e.g. refractive therapy or progressive spectacles) * systemic or ocular conditions which may affect contact lens wear (e.g. allergy and medication) * systemic or ocular conditions which may affect refractive development (e.g. down syndrome, ptosis)

Keywords: myopia astigmatism orthokeratology corneal thickness corneal curvatures corneal biomechanics
efficacy of kangliuwan for recurrent grade iv glioma

Conditions: Glioma of Brain; Recurrence

Summary: a prospective exploratory clinical study to explore the efficacy of hospital traditional chinese medicine preparation kangliuwan for recurrent grade iv glioma.


Eligibility criteria:
inclusion criteria: 1. the patient signed "informed consent" voluntarily; 2. the age of patient is between 18 and 80 years; 3. kps score ≥40 ; the patient has normal liver and kidney function normal heart function better follow-up and compliance; exclusion criteria: 1. the patient did not sign "informed consent" or signed unvoluntarily. 2. non-glioma patients 3. active infection 4. human immunodeficiency virus (hiv) positive 5. hepatitis c or hepatitis b infective 6. pregnancy or breast-feeding women 7. patients did not agree to use effective contraception during treatment and the following 3 months. 8. patients also participated in other clinical studies. 9. the subjects researchers believe are not suitable for participation or completion of the study.
the clinical study on the mangrove sword bean food bar effect for older people

Conditions: Nutrition Disorders in Old Age; Disaster

Summary: the goal of this clinical study is to assess the api-api mangrove sword bean food bar effect on the older people's weight affected by a landslide the main questions aimed to answer are: * can api-api mangrove sword bean food bar improve the weight of older people affected by landslide? * can balanced nutrition education increase the older peoples' knowledge? participants divided in the two groups i.e.: * treatment group received 50 g mangrove sword bean food bar each day during 15 days. * control group received 50 g sword bean food bar each day during 15 days. * both groups obtained balanced nutrition of older people education once at the first week of study.

treatment group received 50 g mangrove sword bean food bar each day during 15 days. control group received 50 g sword bean food bar each day during 15 days. both groups obtained balanced nutrition of older people education once at the first week of study. compliance monitoring to control the food compliance by the subjects at two groups through home visit, weight measurement, three days food recall, and food bar distribution checking by trained enumerators.

Eligibility criteria:
inclusion criteria: * aged 60 years old or above * male and female * living in cihanjuang village, sumedang district, west java province indonesia who affected by the landslide disaster * had normal, under-, or over-nutrition status * not suffering from chronic diseases or degenerative diseases during the study. * willing to avoid consumption of any snacks other than the food bars and plain water. exclusion criteria: * having difficulty mobilities to run daily basic activities. * suffered from infectious and or a chronical diseases.

Keywords: older people disaster weight mangrove-sword bean food bar
virtual health insurance navigation pilot program for childhood survivors (hintii)

Conditions: Childhood Cancer Survivors

Summary: the investigators are conducting a type i hybrid effectiveness-implementation trial to assess the effectiveness of hint-s (synchronous) compared to enhanced usual care (euc) in promoting health insurance literacy, thus reducing worry, unmet health care needs, and financial consequences due to medical costs to improve care and long-term outcomes of childhood cancer survivors. the investigators will also compare hint-s to hint-a (asynchronous), a prerecorded, asynchronous version of the 5 hint-s navigator sessions.

the present study seeks to evaluate a health insurance navigation program with childhood cancer survivors recruited from the long-term follow-up (ltfu) cohort. childhood cancer survivors face health challenges throughout their lives that require monitoring and ongoing care. this is compounded by the tendency among childhood survivors to have higher rates of underinsurance, unmet healthcare needs, and burdensome costs related to care. these burdensome costs also contribute to underutilization of care among survivors. dr. park and her colleagues published findings that suggested ltfu survivors had difficulty in understanding how to use their insurance, and often experienced financial-related distress. understanding and navigating insurance benefits in the current landscape is crucial for cancer survivors to obtain and utilize the health care that they need. with this in mind, the study investigators propose to evaluate the effectiveness of an insurance navigation intervention with ltfu participants, delivered in a synchronous and asynchronous modality. the navigation intervention will be delivered by a health insurance navigator via hipaa-compliant videoconferencing for the synchronous group (hint-s) and will be delivered via pre-recorded video session for the asynchronous group hint-a). participants will be randomized into either the two navigation intervention arms (hint-s and hint-a; approximately 234 per intervention arm), or the enhanced usual care arm (approximately 52 for control arm). the sample size per arm was chosen to enable evaluation of feasibility and acceptability goals, as well as to explore meaningful differences in the outcomes. to assess the proposed primary and secondary outcomes, all trial participants will complete a baseline and 6-month and 12-month post-program follow-up survey.

Eligibility criteria:
inclusion criteria: * are 18 years or older at time of enrollment * are able to give informed consent * have access to a smartphone, computer, or tablet with internet access * have us based health insurance * current ltfu cohort participants * having access to the ccss patient portal. exclusion criteria: * participants from the pilot trial will not be eligible

Keywords: health insurance survivorship