Kornimate/medical-research-clean huggingface dataset:
efficacy and safety assessment of temporal interference stimulation to improve bipolar depression

Conditions: Bipolar Depression

Summary: the aim of this study was to explore the efficacy and safety of temporal interference stimulation to improve bipolar depression, as well as to explore the corresponding neuroimaging mechanisms using magnetic resonance and electroencephalogram to provide novel intervention protocols and objective indicators of efficacy prediction for depressive episodes in bipolar disorder.


Eligibility criteria:
inclusion criteria: * right-handed, and have completed nine years of compulsory education; * meet the diagnostic criteria for bipolar depression in the diagnostic and statistical manual of mental disorders, fifth edition (dsm-5); * ≥18 points on the hamilton depression inventory (hamd- 17); * ≤8 points on the young's mania rating scale (ymrs); * subjects who have not been treated with psychiatric medication, or those who have been treated with medication are required to undergo medication washout within 2 weeks before randomization; * subjects/legal guardians are willing to cooperate with the treatment and sign an informed consent form after they have fully understood the temporal interference stimulation (ti). exclusion criteria: * contraindications to magnetic resonance scanning (mri) or time-interference stimulation (ti), such as the presence of metallic or electronic devices in the body (intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies); * prior or current electroconvulsive therapy (ect), modified electroconvulsive therapy (mect), transcranial magnetic stimulation (tms), transcranial direct current therapy (tdcs), transcranial alternating current stimulation (tacs), or other neurostimulation; * pregnant and lactating women, and women of childbearing age with a positive urine pregnancy; * possesses a diagnosis of another major psychiatric disorder that has been assessed by the study investigator as a major disorder that results in more impairment than a diagnosis of bipolar disorder; * co-morbid other psychiatric disorders, including obsessive-compulsive disorder, personality disorders, anxiety spectrum disorders, mental retardation, substance dependence (abuse), etc.; has active suicidal ideation (≥ 4 points on item 10 of the madrs); * risk of serious injury to self or others; * history of serious physical illness or disease that may affect the central nervous system; * risk of neurologic disorders or seizures, such as previous craniosynostosis, cranial trauma, abnormal electroencephalograms, magnetic resonance evidence of structural abnormalities of the brain, or family history of epilepsy.
quantitative pulmonary imaging registry & biorepository

Conditions: Pulmonary Disease

Summary: the goal of this project is to establish a registry and biorepository of images and biological samples from subjects undergoing novel pulmonary imaging methods to be used for future research aimed toward identifying clinical applications of imaging methods and toward understanding the physiological significance of imaging biomarkers. this registry and biorepository will accelerate the development of these imaging techniques and may lead toward future clinical adoption of quantitative pulmonary imaging.

imaging is increasingly used for the non-invasive assessment of pulmonary health. alongside this increased usage, there is enhanced interest in quantitative imaging methods that provide robust, repeatable, and objective measures of lung structure and function. at the forefront of this effort is quantitative computed tomography (qct). ct imaging is the gold standard for high-resolution imaging of pulmonary structure, and the underlying physics of ct imaging is highly amenable to quantitative analysis. in addition to qct, mri is garnering increased interest as a modality for pulmonary imaging. like ct, mri is non-invasive, and it has the additional advantage of being ionizing radiation-free, making it more suitable for repeat imaging and for use in pediatric patients. traditionally, mri was not often used for lung imaging due to several difficulties regarding the acquisition of quality images in the lungs. however, recent advances to pulmonary mri methods have enabled the acquisition of high-quality images of pulmonary structure and function. these advances include the use of ultra-short and zero echo time (ute and zte, respectively) mri methods, as well as the use of gaseous contrast agents such as hyperpolarized 129xe. despite these advances in qct and mri methods, the clinical applications for these imaging techniques are often unclear. moreover, as new techniques, many of the imaging biomarkers in use have been independently developed by multiple sites and thus require standardization. as such, there is an urgent need both to standardize imaging/analysis techniques and to determine optimal clinical applications for these novel quantitative imaging methods.

Eligibility criteria:
inclusion criteria: * the participant is enrolling/has enrolled in a research study at the university of kansas medical center that involves pulmonary mri and/or pulmonary ct. exclusion criteria: * the participant declines to participate.

Keywords: xenon xe-129 ct
comparison of high-dose methotrexate (hdm) plus doxorubicin to hdm plus etoposide-ifosfamide in osteosarcoma children

Conditions: Osteosarcoma; Localised High Grade Osteosarcoma of the Limbs

Summary: the purpose of this study is to compare two preoperative chemotherapy regimens based on high-dose methotrexate courses given alternately either with doxorubicin or with etoposide-ifosfamide.


Eligibility criteria:
inclusion criteria: * non metastatic limb osteosarcoma, * age less than 20 years, * biopsy proven high-grade osteosarcoma, * no previous treatment, * no contraindication to chemotherapy * no previous malignancy, * written informed consent. exclusion criteria: * juxta-cortical sarcoma and microcellular anaplastic sarcoma, * previous anticancer treatment * contraindication to chemotherapy * previous malignancy,

Keywords: osteosarcoma
the effect of maximum body weight in lifetime on the development of type 2 diabetes

Conditions: Diabetes; Prediabetes

Summary: hypothesis : the maximum body weight in lifetime is associated with the onset of development of type 2 diabetes.

obesity is well recognized risk factor for type 2 diabetes. recent studies reported that weight change, especially severe weight gain was associated with an increased risk of type 2 diabetes. the aim of this study is to investigate whether the maximum body weight of lifetime is associated with the early onset of type 2 diabetes or an increased risk of type 2 diabetes in korean.

Eligibility criteria:
inclusion criteria: * korean with type 2 diabetes * korean with confirmed ifg or igt * korean with ngt exclusion criteria: * malignancy except thyroid cancer * active tuberculosis

Keywords: diabetes prediabetes impaired fasting glucose (ifg) impaired glucose tolerance (igt) body weight
program of intensive support in emergency departments for care partners of cognitively impaired patients

Conditions: Dementia

Summary: dementia is a common problem for older patients presenting to emergency departments and for the family caregivers who often lack support, understanding, and skills to manage the problems related to the need for emergency department visits. the purpose of program of intensive support in emergency departments for care partners of cognitively impaired patients (poised-cpcip, here on referred to as poised) randomized controlled trial is to use previously established quality improvement methods of root cause analysis to uncover reasons for emergency department use and to focus on caregiver activation within a program of dementia care management. the goals of this study are to reduce recurrent emergency department visits and improve caregiver symptoms of depression, anxiety and need for social support.


Eligibility criteria:
inclusion criteria: * must be in the emergency department for care at the point of recruitment * must be english- or spanish-speaking * must have a family member or friend who provides caregiving assistance * must have a plan to be discharged to home (esi = 4 or 5) * must have score \ 3.4 * must have capacity to consent or have a proxy. exclusion criteria: * care recipient (cr) is a resident of a nursing home or other supportive facility * cr scores \> 3 on the minicog or the caregiver assessment by iqcode was \< 3.4 * caregiver (cg) declines participation * cr is not being discharged to home
improving adherence to post pci antiplatelet therapy in minority populations

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to evaluate if the use of a phone based motivational interviewing among minority populations who received a coronary stent can improve adherence to antiplatelet agents from approximately 51% to 66% (15 percentage point increase) at 12 months post stent placement when compared to a mailed educational dvd.

other aims are: 1) improve the self reported adherence of antiplatelet medications 2) identify specific barriers for the use of post pci anti-platelet therapy among minority populations enrolled in humana by administering a short survey at the baseline recruitment call and at the 12 month follow up call, 3) identify predictors of never filling an anti-platelet therapy prescription post pcis. inclusion criteria: we will include black or hispanic patients having coronary stenting using the following codes for bare metal or drug eluting stents: icd-9 procedure codes (36.06) or (36.07), ms-drg codes 247-249 or cpt codes 92980, 92981, c1984 g0290, g0291. the identification period will last approximately 10 months. primary outcome: medication possession ratio as a dichotomous variable (appropriate/not appropriate adherence) and as a continuous variable secondary outcomes: self reported adherence by 4- item morisky medication adherence scale (mmas-4) barriers to appropriate adherence predictors of adherence

Eligibility criteria:
inclusion criteria: * we will identify prospectively all subjects who undergo coronary stenting using the following codes for bare metal or drug eluting stents: icd-9 procedure codes (36.06) or (36.07), ms-drg codes 247-249 or cpt codes 92980, 92981, c1984 g0290, g0291 * we will select subjects identified as black or hispanics by a validated algorithm that uses the medicare race code, geocoding techniques and the spanish surname list. exclusion criteria: 1. lack of medical files to document stent placement. 2. not receiving informed consent. 3. subjects with contraindications for antiplatelet therapy

Keywords: coronary stents medication adherence antiplatelet medications motivational interviewing
methylphenidate treatment response study of genetic polymorphism in attention deficit hyperactivity disorder(adhd)

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the purpose of this study is to determine whether norepinephrine gene polymorphism affect to treatment response in adhd


Eligibility criteria:
inclusion criteria: * diagnosis made by dsm-iv and k-sads-pl * iq \> 71 exclusion criteria: * genetic disorder * history of acquired brain injury * seizure disorder * other neurologic disorder * mental disorder, pervasive developmental disorder * obsessive-compulsive disorder * communication disorder * learning disorder

Keywords: attention deficit hyperactivity disorder polymorphism, single nucleotide slc6a2 protein, human adra2a protein, human
effect of cervical spinal stabilization exercise programs by magnetic resonance imaging in healthy individuals

Conditions: Healthy

Summary: the aim of this study was to investigate the morphological changes in the neck muscles of cervical spinal stabilization exercises focused on flexor and extensor muscles applied to healthy individuals.

in the prevention and treatment of cervical region pathologies, various exercise methods are applied in the clinic. the clinical exercises vary according to the time and severity of the pathology but also according to the pathology itself. these exercises include exercises focusing on flexor or extensor muscles. the aim of this study was to investigate the morphological changes in the neck muscles of cervical spinal stabilization exercises focused on flexor and extensor muscles applied to healthy individuals. at least 27 healthy male subjects between the age of 18-30 are planned to be included in the study. individuals will be divided into 3 groups by simple randomization method. in one group cervical stabilization exercise program focused on the flexor muscles will be applied and the other group cervical stabilization exercise program focused on the extensor muscles will be applied for 8 weeks. individuals in the control group will only be evaluated without exercise. in the study, by using magnetic resonance imaging (mri) method as the main evaluation, muscle anatomical cross-sectional area and t2 relaxation time measurements will be made and morphological changes in muscles will be determined. these evaluation procedures will be performed on longus colli, sternocleidomastoid, semispinalis cervicis, multifidus and upper trapezius muscles. as additional evaluation methods, muscle strength and muscle endurance tests, normal joint motion measurements, posture evaluation and mri measurement of cervical spine curvature will be performed. all evaluations will be performed at the beginning and at the end of these 8 weeks and the effects of the exercises applied on the muscles in the two groups will be examined.

Eligibility criteria:
inclusion criteria: * being healthy * age between 18 to 30 years * agree to participate in the study exclusion criteria: * to undergo any surgical procedure of the vertebral column * inflammatory disease * rheumatological disease * history of malignancy * congenital spinal cord anomaly * congenital and/or spinal deformities * radiculopathy * myelopathy * other neurological disorders * vestibular disorders and/or trauma history

Keywords: cervical spinal stabilisation exercises muscle cross sectional area muscle t2 relaxation time
in-vitro maturation of oocytes from polycystic ovarian patients undergoing ivf

Conditions: Polycystic Ovarian Syndrome

Summary: retrieval of immature oocytes from women with polycystic ovaries, their in-vitro maturation, fertilization and embryo transfer can prevent hormonal treatment that can lead to ovarian hyperstimulation. in addition, it can decrease discomfort and side-effects of routine daily administration of hormones and it can be cost-effective. thirty healthy women with polycystic ovarian syndrome aged 20-35, with bmi 18-30 kg/msq will be included in the study. their immature oocytes will be retrieved from small follicles without any hormonal treatment. the oocytes will be fertilized post in-vitro maturation. the developed embryros will be transferred to the patients as in a routine ivf cycle.


Eligibility criteria:
inclusion criteria: * healthy women diagnosed with polycystic ovarian syndrome with bmi 18-30 kg/sqm, aged 20-35 exclusion criteria: * every one else

Keywords: pco/pcod ivm immature oocytes
the psean study - study protocol

Conditions: Abdominal Trauma; Follow-up in Abdominal Trauma

Summary: the researchers aim to study the role of contrast ultrasound in detecting post-traumatic splenic, hepatic, and renal pas compared with the gold standard of ct with intravenous contrast at different follow-up time points, and whether it can replace ct scan in the follow-up of solid organ injuries

adult patients (18 years old and above) with proven blunt or penetrating splenic and/or liver and/or renal trauma as shown by a ct scan and classified according to the american injury scale american association for surgery (aast) organ injury scale (ois) with ois iii and above will undergo a follow-up with both a ceus and ct scan to detect post-traumatic parenchymal pseudoaneurysm within two to five days from injury. follow-up over five days post-admission will be included if they were performed within the same hospitalization

Eligibility criteria:
inclusion criteria: * adult patients (18 years old and above) with proven blunt or penetrating splenic and/or liver and/or renal trauma as shown by a ct scan and classified according to the american injury scale american association for surgery (aast) organ injury scale (ois) will be included exclusion criteria: * minor to 18 years old

Keywords: trauma ct scan ceus follow up abdominal pseudoaneurism
respiratory microbiome in copd and associated inmune response.

Conditions: Pulmonary Disease (COPD), Chronic Obstructive

Summary: hypothesis: copd patients with frequent exacerbations have different pulmonary and systemic immune response than copd patients without frequent exacerbations and this is related to their microbiome.

the objective of this project is to determine the pulmonary microbiome and its relationship with the pulmonary and systemic inmune response in copd patients with frequent (fe) and non frequent exacerbations (ne). 1. the pulmonary immune response. -the role of mucins, antimicrobial peptides (amps), matrix metalloproteinases (mmps) and toll-like receptors (tlrs) as lung defense mechanisms and their possible relationship with the microbiome in copd and fe patients. 2. the systemic immune response. -the pulmonary and blood inflammatory response and circulating bacterial products as markers of the systemic immune response.

Eligibility criteria:
inclusion criteria: 1. diagnosis of copd according to national and international guidelines. 2. clinical stability (8 previous weeks). 3. signature of informed consent. exclusion criteria: 1. antibiotic treatment the previous 8 weeks. 2. other lung diseases. 3. active neoplasic disease. 4. terminal concomitant disease.
a study for type 2 diabetic patients

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of the study is to compare the insulin lispro low mixture (1, 2 or 3 daily injections) with insulin glargine (alone or with 1, 2 or 3 insulin lispro daily injections) on lowering the blood sugar level


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * receiving oral antihyperglycemic medications (including metformin) without insulin injection in the last 90 days * hemoglobin a1c (hba1c) equal to or greater than 7.0% but less than 11.0% * willing to receive insulin injection while continuing to take the prestudy oral antihyperglycemic medications * able to perform self monitoring of blood glucose exclusion criteria: * are taking any other glucose-lowering agents other than metformin, sulfonylurea or thiazolidinedione (pioglitazone) * have taken acarbose, miglitol, pramlintide, exenatide, repaglinide, or nateglinide in the past 6 weeks, or for a total of 30 days or more, in the last 24 weeks * have a body mass index greater than 35 kg/m2 * history or presence of kidney disease * have cardiac disease (class iii or iv)
multi modal stimulations in pre-term neonates

Conditions: Preterm Birth; Infant, Premature, Diseases

Summary: a total of 56 neonates with lbw will recruited by the convenience sampling to participate in this two group pre-test post-test, single blinded randomized clinical study. after the demographics, recruited nlbw will be randomly divided into two groups, group a and group b with block randomization. there will be four blocks, with the matrix design of 4x14 here 14 being rows. each block contained 4 chits (2 chits for each group), totalling 56. the subjects will be allotted to the group based on the randomly chosen chit by their parents. once the block will be allotted, next row block was opened. thus, equal number of nlbw will be assigned to each group over time. group a will be receiving multimodal sensory and kinesthetic stimulation (msks) and group b will be receiving regular lifesaving hospital care. group a will receive the interventions for 2 weeks period, totalling 10 sessions. each session will last for 30 minutes duration.


Eligibility criteria:
inclusion criteria: 1. infants born between 28 and 36 week of gestation 2. birth weight ranging from 1000-2500 g. 3. medically stable preterm infants exclusion criteria: 1. medically unstable preterm infants. 2. infants with congenital anomalies, congenital infections and central nervous system injury

Keywords: preterm neonate multi-modal stimulation
pediatric emergency department decision support system to reduce secondhand smoke

Conditions: Asthma; Smoking Cessation

Summary: this two phase study will develop and evaluate a pediatric emergency department (ped) decision support system (dss)-electronic medical records (emr) system to facilitate the identification of smokers and the delivery of a second hand smoke (shse) exposure intervention to caregivers who bring their child to the ped.

the study will be the first to develop and evaluate a pediatric emergency department (ped) decision support system (dss)-electronic medical records (emr) system to facilitate the identification of smokers and the delivery of a second hand smoke (shse) exposure intervention to caregivers who bring their child to the ped. the investigators will conduct a two-phased project to develop, refine, and integrate a decision support system into the current electronic medical record system. in phase i, the investigators will develop a three-part dss with prompts to: 1) ask about child shse and caregiver smoking 2) use a software program (redcap) to advise caregivers to reduce their child's shse via total smoking home and car bans and quitting smoking, and 3) assist caregivers to quit by directly connecting them to their choice of free cessation resources (e.g., quitline, txt2quit, smokefree.gov) during the ped visit. if the investigators discover that a teen participant is a smoker, the investigators will provide them with resources for the quitline, tx2quit, and teen.smokefree.gov. the investigators will create reports to provide feedback to nurses on their shse counseling behaviors. nurses will provide input on program content, functions, and design. in phase ii, the investigators will conduct a 3-month feasibility trial to test the results of implementing the dss on changes in nurse shse-related behaviors, and child and caregiver outcomes.

Eligibility criteria:
inclusion criteria: * nurses who work at least 2 shifts per week * current smokers accompanying their 0-18 year old child to the emergency department or urgent care exclusion criteria: * non english speaking families

Keywords: bronchiolitis cough ear infection respiratory infection wheezing clinical decision support systems
transcutaneous electrical nerve stimulation treatment of renal colic

Conditions: Renal Colic

Summary: the aim of the present trial was to investigate the analgesic efficacy and safety of transcutaneous electrical nerve stimulation treatment in patients with renal colic within the emergency department.

renal colic, an intensely painful condition, is a common presenting complaint to the emergency department. parenteral opioids, nonsteroidal anti-inflammatory drugs and acetaminophen are commonly used to provide relief from renal colic. the aim of the present trial was to investigate the analgesic efficacy and safety of transcutaneous electrical nerve stimulation treatment in patients with renal colic within the emergency department. study design and setting: a prospective, randomized, double-blind, placebo controlled, single-center, clinical trial will be conducted in emergency department of a tertiary care university hospital.

Eligibility criteria:
inclusion criteria: 1. adult patients with renal colic admitted to emergency department. 2. adult patients who were definitively diagnosed with acute renal colic due to urinary system stones using unenhanced computed abdominopelvic tomography exclusion criteria: 1. patients below 18 years of age 2. patients with haemodynamic instability, with fever (temperature=38°c \[100.4°f\]), with evidence of peritoneal inflammation, 3. patients using any analgesic within the previous 48 hours of emergency department presentation 4. patients who declined to participate

Keywords: transcutaneous electrical nerve stimulation emergency medicine