Kornimate/medical-research-clean huggingface dataset:
the impact of dry eye syndrome on metrics of low contrast vision before and after meibomian gland expression

Conditions: Meibomian Gland Dysfunction

Summary: the study aims to determine the impact of meibomian gland dysfunction (mgd) dry eye on low contrast black/white (luminance) and cone color sensitivity performance and improvement in these functions after in-house non-invasive meibomian gland (mg) expression.

this study offers possible benefits from gland expression to patients and subjects in terms of clinical measurements and care associated with meibomian gland dysfunction impacting all age ranges. prior studies show that these interventions improve dry eye symptoms with intent to improve vision, low contrast color, and b/w vision after intervention in this study.

Eligibility criteria:
inclusion criteria: * individuals over the age of 18 years * healthy individuals with reported symptoms of dry eye such as burning, stinging, fluctuating vision, inappropriate tearing, and feelings of grittiness particularly with prolonged near work exclusion criteria: * under the age of 18 * individuals currently using prescription eye medications for dry eye / mgd / inflammation / infections or any other treatments.
develop novel methods to display, report and analyze cgm data for clinical decision-making in people with diabetes

Conditions: Diabetes; Glucose Variability; CGM

Summary: the purpose of this study is to obtain sufficient continuous glucose monitoring (cgm) data in a manner that provides clinical information that is not available using conventional self-monitored blood glucose. currently, a formal method does not exist for evaluating cgm data except for looking at each glucose reading across the days a cgm system has been worn and evaluating it based on clinical practice experience. the hope is that a mathematical model can be developed that will enable health care providers to quickly and easily determine what changes in diabetes treatment need to be made after cgm data is obtained.

there are two purposes to the study. first, to use an investigational device, the freestyle navigator continuous glucose monitoring (cgm) system (abbott diabetes care) to obtain sufficient longitudinal data in order to develop a method for reporting cgm data in a manner that provides clinical information that is not available using conventional smbg. the long-term goad is to determine the manner and degree to which cgm contributes to clinical decision-making. because of the evidence that glucose regulation may be indirectly related to blood pressure levels, a second purpose of the study is to monitor variation in bp control by means of self-monitored bp.

Eligibility criteria:
inclusion criteria: * male or female * diagnosed with type 1 or type 2 diabetes * treated with insulin therapy * can also be taking other diabetes medication treatment * age 21 and older * willing to give informed consent * capable of following the protocol and instructions of study staff * available for scheduled visits * access to telephone communications exclusion criteria: * under 21 years of age * unable to follow protocol * unable to read and write in english * skin abnormalities at insertion sites * allergy to adhesives * any concomitant medication thay would likely affect evaluation of device

Keywords: diabetes cgm
psychosocial group interventions for depression

Conditions: Depression

Summary: a total of 384 patients suffering from chronic depressive disorder will be randomized to receive treatment as usual, cbasp, or befriending for a period of five months. the primary outcome is change in montgomery-åsberg depression scale. secondary outcomes include changes in self-reported psychiatric symptoms, biomarkers determined from venous blood samples, and neurophysiological parameters. the data gathering is performed at pre- and post intervention stages (i.e., at baseline and at five months). a follow-up questionnaire is sent to the participants six months after the intervention.

the efficacy of 20-week group-cbasp as compared to tau is evaluated by rct in a psychiatric outpatient clinics. the recruition is completed.

Eligibility criteria:
inclusion criteria: * age 18-65 * moderate or severe major depression with duration of a minimum of two years or "double depression" (dysthymia and moderate/severe major depression simultaneously) or moderate or severe major depression with duration of a minimum of two years, only partially remitted during the time period exclusion criteria: * psychotic disorder * bipolar disorder * current substance abuse (excluding nicotine)

Keywords: depression treatment as usual cbasp befriending
adipocyte-derived extracellular vesicles, weight loss, and endothelial function

Conditions: Obesity; Weight Loss

Summary: changes in adipose tissue biology are now recognized as a key factor underlying the increased risk of metabolic and cardiovascular disease with obesity. clinical interest in adipocyte-derived extracellular vesicles (ad-evs) has intensified due to their potential as circulating biomarkers of adipose tissue health and systemic messengers, regulators and mediators of cardiometabolic health and disease with obesity. the investigators hypothesize that elevated ad-evs in adults with obesity will be negatively associated with endothelium-dependent vasodilation. furthermore, the investigators hypothesize that in adults with obesity, intentional weight loss-induced reduction in circulating ad-evs is associated with greater endothelium-dependent vasodilation.


Eligibility criteria:
inclusion criteria: * age ≥40 years * bmi \ 25 kg/m2 for phase 1 and bmi \>25 kg/m2 for phase 2. rationale for defining obesity as bmi \>25 kg/m2 exclusion criteria: * current smoker * chronic overt medical condition (e.g., evidence of coronary artery disease on resting ecg, any history of myocardial infarction or stroke, or cancer, diabetes based on fasting blood glucose concentration) * alcohol abuse or dependence defined as more than 14 standard drinks/week and no more than 4 standard drinks/day for men and 7 standard drinks/week and 3 standard drinks/day for women (a standard drink is defined as 12 ounces of beer, 5 ounces of wines, 1 ½ ounces of 80-proof distilled spirits) reported during the medical history/physical exam * stage iii hypertension (systolic blood pressure \>160 mmhg and/or diastolic blood pressure \>100 mmhg) * regular vigorous aerobic/endurance exercise (\>3 bouts/week, \>30 minutes/bout at a workload \>6 mets) * women who are pregnant or breastfeeding * history of anaphylaxis to betadine, lidocaine, iodine * raynaud's disease * history of clotting disorders * anyone taking blood thinners and clotting medications * anyone taking statin medication * planned pregnancy in coming 4-6 months

Keywords: obesity weight loss
impact of covid-19 on pregnancy outcomes: a systematic review

Conditions: COVID-19; Pregnancy Outcomes; Maternal Health; Neonatal Health

Summary: this systematic review aims to evaluate the impact of covid-19 on pregnancy outcomes. it synthesizes data from various studies to provide insights into the effects of the virus on maternal and fetal health. the review focuses on key outcomes such as preterm birth, maternal complications, and neonatal health, utilizing comprehensive literature from peer-reviewed journals. by analyzing existing studies, we aim to identify trends and gaps in research regarding covid-19 and pregnancy. this review is intended to inform healthcare providers and pregnant individuals about potential risks and considerations during the pandemic.


Eligibility criteria:
inclusion criteria: * pregnant individuals diagnosed with covid-19. * studies reporting pregnancy outcomes related to covid-19 published between january 2020 and the present. * articles that include quantitative data on maternal and fetal outcomes. exclusion criteria: * studies that do not report on covid-19-related pregnancy outcomes. * non-peer-reviewed articles or grey literature. * research focusing on non-pregnant populations.
exercise after lumbar disc herniation surgery

Conditions: Disc Herniation; Surgery

Summary: physical therapy and rehabilitation may improve low back pain and quality of life after lumbar disc herniation. but there is not any agreement of its optimal start time, and rehabilitative methods. this study evaluates the effects of early and late rehabilitation to the low back pain and quality of life following unilateral microdiscectomy.

lumbar disc herniation (ldh) is a frequently encountered ailment in neurosurgery clinics and is prevalent among the general populace, with a reported incidence of about 2%. as it is primarily observed in the workforce, it adversely affects their quality of life. one common reason for referring a patient for surgery is radiculopathy and low back pain co-occurrence. ldh is typically observed in the adult population in active occupation. most patients with ldh can be treated conservatively, but surgery may be necessary for around 13% of cases. the decision to operate depends on the individual patient, but persistent radicular pain and neurological dysfunction unresponsive to conservative treatment are common indications. minimally invasive surgical techniques are becoming more prevalent. currently, microsurgery is the most common approach for lumbar disc herniation. in addition, endoscopic and minimally invasive surgeries have become more prevalent. lumbar microdiscectomy is a surgical procedure involving discectomy with paravertebral muscle dissection. subsequently, patients may experience postoperative back pain, potentially impacting their quality of life. physical rehabilitation is frequently suggested following surgery. some studies have indicated that physical therapy and rehabilitation may not significantly improve low back pain and quality of life after lumbar disc herniation. there is yet to be an agreement on the effectiveness of physical therapy, its optimal start time, and rehabilitative methods. this study evaluates the effects of early and late rehabilitation following unilateral microdiscectomy for lumbar disc herniation. it also examines the differences in low back pain and patients' quality of life due to exercise.

Eligibility criteria:
inclusion criteria: * radicular pain that persisted despite 4-6 weeks of conservative treatment, * detection of single-level disc herniation in mri lumbar microsurgery. * individuals who underwent single-level unilateral lumbar microsurgery. those with a surgical incision \<3 cm. exclusion criteria: * individuals with more than one level of muscle exposure at the time of surgery. * those with a skin incision \>3 cm

Keywords: lumbar disc herniation lumbar microdiscectomy physical exercise
long-term outcome after heparin and edoxaban versus heparin plus vit k antagonists for acute dvt and pe

Conditions: Post Thrombotic Syndrome; Deep Vein Thrombosis; Chronic Thromboembolic Pulmonary Hypertension

Summary: centers that participated in the hokusai vte trial will be invited to collect follow of previously enrolled patients at least 2 years after the index vte.

hokusai vte trial was a randomised double blind non inferiority trial that compared the efficacy and safety of heparin ) (enoxaparin or unfractionated heparin) followed by edoxaban with heparin (enoxaparin or unfractionated heparin) followed by warfarin (target inr 2-3) in patients with acute, symptomatic vte. centers that participated in the hokusai vte trial will be invited to collect follow of previously enrolled patients at least 2 years after the index vte. patients with index dvt will be asked to complete the sf-36 and pembqol questionnaire to assess the (venous disease-specific) quality of life. the villalta score will be used to assess pts. the objectively and subjectively obtained villalta score- known as the patient reported villalta -will be compared . among patients with with an index pe, the qol will be assessed bu the validated generic (sf-36) and dvt at index will be examined for pts and will be asked to complete all questionnaire.

Eligibility criteria:
inclusion criteria: * patient who participated in the hokusai vte trial exclusion criteria: * patient deprived of liberty * patient under guardianship
effect of optimized behavioural intervention using the multi-phase optimization strategy (most).

Conditions: Dental Caries in Children; Early Childhood Caries

Summary: in the current study, most approach is proposed, to engineer an oral health behavior modification intervention, to increase the engagement of mothers in brushing their pre-school children's teeth.

the first phase of this study will be the preparation phase. this will comprise the development of a conceptual framework and conducting a feasibility pilot study consisting of three intervention components: motivational interviewing (mi), oral health promotion messages (ohpm), and storytelling (st). the second phase of the study is the optimization phase which constitutes a factorial trial of the three selected intervention components (mi, ohpm and st). each component will be set at two levels: yes (the intervention is applied) vs no (the intervention is not applied).

Eligibility criteria:
inclusion criteria for mother's of children enrolled in study: * has children between 2 and \<5 years of age * has children with high plaque index scores (pli≥2 or visible plaque accumulation on maxillary anterior teeth). * literate and owns a mobile phone with already set-up or possibility to set-up whats-app messenger application. * willing to participate in the study and receive periodic ohpm and st videos. exclusion criteria: * mothers of children who are not willing to cooperate and show a definite negative behavior (rating 1 frankel's classification). * mothers of children who are physically disabled or medically compromised. * mothers of children in need of emergency dental treatments.

Keywords: most, behavioural intervention, early childhood caries
ultrasound and near infrared imaging for predicting and monitoring neoadjuvant treatment

Conditions: Breast Cancer; Breast Tumors; Cancer of Breast; Cancer of the Breast; Malignant Neoplasm of Breast

Summary: to determine the accuracy of nir/us assessment of tumor vasculature and oxygen changes in predicting and monitoring early neoadjuvant treatment response compared to pathological response.


Eligibility criteria:
inclusion criteria: * scheduled to receive neoadjuvant chemotherapy for the treatment of newly diagnosed, locally advanced breast cancer or scheduled to receive neoadjuvant endocrine therapy with the eventual goal of surgery of newly diagnosed clinical stage ii-iii er+ her2- breast cancer (for the endocrine therapy cohort) * at least 18 years of age * female * able to understand and willing to sign an irb-approved written informed consent document exclusion criteria: * pregnant and/or breastfeeding * prior history of breast cancer * prior history of chest wall radiation * prior history of breast reconstruction, reduction, or augmentation
air optix extended wear contact lenses

Conditions: Refractive Errors

Summary: the purpose of this post-market clinical follow-up (pmcf) study is to assess long term performance and safety of air optix aqua sphere, air optix plus hydraglyde sphere, and air optix plus hydraglyde toric soft contact lenses in a real-world setting when worn as extended (overnight) wear.

this is a non-interventional/observational study designed as a retrospective chart review. study sites will identify charts within their existing databases in a fair and consistent manner, e.g., reviewing all eligible charts in reverse chronological order by year of baseline visit. subjects/charts meeting the eligibility criteria will be enrolled in the study. the data collection period is defined as any approximately 1-year to 3-year timeframe since the respective lens brand was prescribed.

Eligibility criteria:
inclusion criteria: * manifest refraction cylinder less than or equal to 0.75 diopter (d) in each eye at baseline (sphere wearers only); * best corrected visual acuity (bcva) of 20/25 snellen or better in each eye at baseline; * must have worn or be wearing air optix aqua sphere, air optix plus hydraglyde sphere, air optix plus hydraglyde toric, biofinity sphere or biofinity toric for at least 3 years in an extended wear modality, as determined by the investigator; * other protocol-defined inclusion criteria may apply. exclusion criteria: * any recurrent history or active anterior segment infection, inflammation or abnormality contraindicating regular contact lens wear at baseline; * use of systemic or ocular medications contraindicating regular contact lens wear at baseline and/or during the period of the retrospective chart collection; * slit lamp findings, including signs of pathological dry eye, that would contraindicate regular contact lens wear; * other protocol-defined exclusion criteria may apply.

Keywords: contact lenses
travelers' diarrhea (td) vaccine pivotal efficacy study

Conditions: Travelers' Diarrhea

Summary: the purpose of this study is to evaluate the efficacy of the travelers' diarrhea vaccine system to actively immunize against enterotoxigenic escherichia coli disease in a field setting.


Eligibility criteria:
inclusion criteria: * 18-64 years of age at date of first vaccination * good health as determined by medical history and physical inspection * females of child-bearing potential must have a negative pregnancy test prior to first vaccination in teh country of origin; females of child-bearing potential must agree not to become pregnant throughout the duration of the study * subjects must have planned travel to an area within 3 hours traveling distance of mexico city, cuernavaca, guadalajara, oaxaca, or san miguel de allende, mexico or antigua, quezaltenango, guatemala city, or solola, guatemala for a minimum duration of stay 7 days (no maximum stay is specified for inclusion). * subject must be able to communicate in english exclusion criteria: * abnormalities as determined by the investigator/clinician during physical inspection * participated in research involving investigational product within 30 days before planned date of first vaccination * ever received lt, etec, or cholera vaccine * history of diarrhea while traveling to a developing country within the last year * women who are pregnant or breastfeeding * clinically significant underlying enteric, pulmonary, cardiac, liver or renal disease * history of irritable bowel syndrome * seizure disorder within the last year * current use of immunosuppressive therapy (excluding inhaled steroids) or current immunodeficiency * known or suspected alcohol abuse or illicit drug use within the last year * medical history of hiv, hbv, or hcv * an employee of a study site * known allergies to any component of the vaccine, including adhesives * planned use of antibiotics with known activity against gram negative facultative anaerobes * planned use of antacids, antidiarrheals, loperamide, bismuth subsalicylate, diphenoxylate or similar during the surveillance phase of the study * an employee of intercell (global) or an immediate family member

Keywords: prevention of travelers' diarrhea
hydroxyzine and risk of prolongation of qt interval

Conditions: Hydroxyzine; Long QT Syndrome

Summary: on 04/30/2015, ansm (the national security agency of medicines and health products) shared an information for general practicioners, pediatricians, anesthesiologists, dermatologists, geriatricians, psychiatrists, community pharmacists and hospital about using hydroxyzine and the associated risk of qt prolongation on the electrocardiogram. drugs containing hydroxyzine (the best known and most used is the atarax®) are used in france in various indications including the treatment of minor manifestations of anxiety, premedication with general anesthesia and the symptomatic treatment of urticaria. a prolonged qt interval is a known risk factor for occurrence of torsades de pointes which can cause sudden death. we distinguish congenital and acquired long qt interval. the main cause of acquired long qt interval is a drug inhibition of the herg potassium channel 1. many drugs have been reported to cause sudden death by prolongation of qt interval and occurrence of torsades de pointes (macrolides, anti -arythmics, some psychotropic ...) the molecules based on hydroxyzine are known to be at risk of prolongation of qt interval in an experimental point of view but is not clearly identified in daily clinical practice. pharmacology unit of caen was the first to publish a case of qt prolongation under hydroxyzine . through this publication, associated with other clinical data, hydroxyzine has been added to the list of drugs that can induce qt prolongation . despite these recent recommendations, it does not seem that hydroxyzine prescriptions were changed daily and therefore the risk of qt prolongation persists. we therefore propose the study of the impact of hydroxyzine on the qt interval measured on the electrocardiogram in patients hospitalized at the university hospital of caen.


Eligibility criteria:
inclusion criteria: * patients hospitalized at the university hospital of caen with a new prescription of oral hydroxyzine by their referring doctor. * patient 'stable' in hospital in a health service or surgery. * age \> 18 years old. exclusion criteria: * unstable patient hospitalized in an intensive care unit or intensive care. * patient refusing participation in the study. * age \<18 years old.

Keywords: hydroxyzine long qt