Kornimate/medical-research-clean huggingface dataset:
direct mechanical thrombectomy versus bridging therapy

Conditions: Thrombectomy; Ischemic Stroke; Large-Artery Atherosclerosis (Embolus/Thrombosis)

Summary: this study compares the efficacy and safety of direct mechanical thrombectomy versus bridging therapy in patients with anterior circulation large vessel occlusion in a cohort of patients treated at the stroke unit of a single centre at alexandria university in egypt.

this study compares the efficacy and safety of direct mechanical thrombectomy versus bridging therapy in patients with anterior circulation large vessel occlusion in a cohort of patients treated at the stroke unit of a single centre at alexandria university in egypt. in the first arm, 17 patients were recruited and underwent direct mechanical thrombectomy without receiving recombinant tissue plasminogen activator. in the bridging therapy arm, 34 patients received first tissue plasminogen activator then underwent direct mechanical thrombectomy. the efficacy was evaluated by the nihss improvement 24 hours following stroke onset and the modified rankin scale 3 months following stroke. safety was assessed by the procedural complications rate especially the hemorhagic transformation.

Eligibility criteria:
inclusion criteria: * patients with anterior ischemic stroke due to large vessel occlusion. * a previous autonomous modified rankin scale (mrs) of less than 2. * a national institutes of health stroke scale (nihss)≥4 * a groin puncture within 4.5 hours of the neurological deficit onset. exclusion criteria: * imaging documentation of intracranial haemorrhage * a premorbid mrs score of 2 or more * absence of diffusion perfusion mismatch in ct perfusion.

Keywords: ischemic stroke direct mechanical thrombectomy bridging therapy
new intubation method to achieve circulatory stability and to reduce number of intubation attempts in neonates

Conditions: Intubation; Difficult or Failed; Preterm Infant; Term Infant

Summary: this is a randomized controlled pilot study investigating a new intubation method in newborn infants. in contrast to the conventional intubation method, in the new method the respirator is connected to the tube prior to insertion into the mouth (oral intubation) or into the nose (nasopharyngeal intubation). as a result, an oxygen flow is already administered via the tube during the intubation process. heart rate, arterial oxygen saturation (spo2) and cerebral tissue oxygenation (using near-infrared spectroscopy) are recorded in both the study and control groups during intubation. hypothesis * the new intubation method is safe * the new intubation method leads to a reduction in the number of intubation attempts * the new intubation method leads to a reduction of desaturations and bradycardia during intubation * in the long term, it could lead to a reduction in morbidity and mortality


Eligibility criteria:
inclusion criteria: * preterm and term born neonates who are hospitalized at neonatal intensive care unit, medical university of graz, austria. * fulfillment of indication for intubation exclusion criteria: - malformation of the upper respiratory tract
intrathecal transplantation of mesenchymal stem cell in patients with als

Conditions: Amyotrophic Lateral Sclerosis

Summary: als is a debilitating disease with varied etiology characterized by rapidly progressive weakness, muscle atrophy and fasciculations, muscle spasticity, difficulty speaking (dysarthria), difficulty swallowing (dysphagia), and difficulty breathing (dyspnea). als is the most common of the five motor neuron diseases.riluzole (rilutek) is the only treatment that has been found to improve survival but only to a modest extent. it lengthens survival by several months, and may have a greater survival benefit for those with a bulbar onset. it also extends the time before a person needs ventilation support.stem cell transplantation is a new hopeful way to improve the patients conditions and reduce the period of disabilities.

in this study our purpose is to evaluate the safety of intraventricular injection of bone marrow derived mesenchymal stem cell.the patients who are eligible,underwent bone marrow aspiration.after cell separation and preparation,the patients underwent mesenchymal stem cell intraventricular injection by stereotaxis.after injection he will be under observed in icu to monitor the adverse events(allergic and neurological side effects).patients are followed 1th,3th ,6th and 12 months after injection and each time these parameters are checked:als-frs,emg-ncv,fvc,side effect check list.

Eligibility criteria:
inclusion criteria: * age:18-65 * both gender * duration of disease\<2 years * fvc\>40% als-frs\>26 exclusion criteria: * neurological and psychiatric concomitant disease * concomitant systemic disease * treatment with corticosteroid,ig,immunosuppressive during 12 months.

Keywords: als intrathecal injection bone marrow mesenchymal stem cell
module on preventing fire, burns and scalds injury among children

Conditions: Burn Injury

Summary: the main aim of this intervention study is to test the hypothesis if school based educational intervention program will significantly improve the knowledge of primary school student on childhood burn prevention in kuala lumpur. the secondary aim the evaluate the association of demographics background, burn injury history with knowledge on burn. the study was conducted in 12 primary school in kuala lumpur from 1st january 2015 to 31st december 2017 in three different phases.

according to world health organization data, approximately 10% of all unintentional injury deaths are due to fire-related burns. in malaysia, burn represent about 5.6% (745 cases) of all injuries among children. as childhood burn was not considered as a child health problem comparing to other childhood illnesses, parents and children tends to have less priority in overcome this issue. this highlights the need to transfer the knowledge especially to the children on the burn prevention. by implementing this module on preventing fire, burns and scalds injury among children, knowledge on main causes of burns and their immediate management can be improved at young age.

Eligibility criteria:
inclusion criteria: * students who are aged 7 till 11 years old * parent or guardian of each selected student above exclusion criteria: ● students under special needs class (pendidikan khas)

Keywords: fire burn injury children scalds
prevention of recurrence of diverticulitis

Conditions: Diverticulitis

Summary: the purpose of this study is to determine whether spd476 is effective in reducing recurrence of diverticulitis.


Eligibility criteria:
inclusion criteria: 1. males and females =\>18yrs of age. 2. if female of childbearing potential (focp), has demonstrated a negative beta hcg (human chorionic gonadotropin) serum pregnancy test, and agrees to comply with any applicable contraceptive requirements of the protocol. 3. an episode of acute diverticulitis that resolved without colonic resection. 4. confirmation of diverticulosis via endoscopic evaluation of the sigmoid colon with at least three diverticula noted. exclusion criteria: 1. previous colorectal surgery, including surgical intervention for diverticular disease (with the exception of haemorrhoidectomy, colonic removal of polyps, and appendectomy) 2. active peptic ulcer disease 3. history of or current presence of inflammatory bowel disease (ibd) 4. subjects with active irritable bowel syndrome (ibs) requiring ongoing medication 5. allergy or hypersensitivity to aspirin or related compounds 6. allergy to radiologic contrast agents 7. use of another investigational product within 30 days of baseline 8. use of antibiotic therapy within 4 weeks of baseline 9. within 14 days of baseline, use of prebiotic, probiotic or 5-asa medications, as well as drugs active at the 5ht-receptor or anti-spasmodic agents 10. use of systemic or rectal steroids within 6 weeks of baseline. use of inhaled or nasal steroids is acceptable 11. use of anti-inflammatory drugs, (nsiads, cox-2 inhibitors) including aspirin (except for cardiac prophylaxis) and ibuprofen, on a regular and ongoing basis 12. history of alcohol or other substance abuse within the previous year 13. active or recent history of endometriosis or dysmenorrhoea within 6 months prior to baseline 14. females who are lactating
saizen® solution for injection adult growth hormone deficiency (ghd) immunogenicity study

Conditions: Growth Hormone Deficiency (GHD)

Summary: to assess the immunogenicity of saizen® solution for injection in adult subjects with documented growth hormone deficiency (ghd).


Eligibility criteria:
inclusion criteria: * adult male and female subjects, 18-60 years of age, inclusive, at the time the informed consent is signed * subjects who have confirmed adult ghd * subjects who are growth hormone (gh) treatment-naive or had received saizen® (freeze-dried formulation) for pediatric ghd (pghd), or are currently receiving saizen® freeze-dried formulation for adult ghd (aghd) * subjects who have binding antibody-negative (babs-) at screening * subjects who have no evidence of concomitant disease, intercurrent illness, or resultant therapy that would interfere with subject compliance, the evaluation of study results, or compromise the safety of the subject * female subjects of childbearing potential who have a negative serum pregnancy test at the screening visit (and at each scheduled visit during the study) * subjects who are willing to comply with the procedures of the study * subjects who are willing to sign an independent ethics committee/institutional review board approved informed consent form * other protocol-defined inclusion criteria may apply exclusion criteria: * subjects who are currently receiving or have previously received treatment for adult ghd or any other indication, including pghd, with a commercial gh product other than saizen® freeze-dried formulation * subjects who had a chronic underlying disease within 6 months prior to screening or concomitant medication(s) that in the opinion of the investigator would exclude the subject from the trial * subjects who have significant renal impairment * subjects who have diabetes mellitus * subjects who are immunosuppressed * subjects who have a current malignancy or a history of any malignancy (excluding fully-treated basal cell carcinoma) * subjects who have participated in another study and received an investigational drug within 30 days prior to screening visit * subjects who have clinically significant abnormal laboratory value(s) * subjects who have known hypersensitivity or allergy to exogenous human gh or any of the excipients or phenol, the bacteriostatic agent in the saizen® solution for injection * other protocol-defined exclusion criteria may apply

Keywords: adult growth hormone deficiency (aghd) immunogenicity growth hormone antibodies gh biomarkers igf-i
exparel ipsa block in knee arthroplasty

Conditions: Pain, Postoperative; Osteo Arthritis Knee

Summary: this is a case series to assess the clinical utility of an intra-articular posteromedial surgeon administered (ipsa) block in patients undergoing primary unilateral total knee arthroplasty.

exparel is approved by the food and drug administration (fda) for use in adults to produce postsurgical regional analgesia via an adductor canal block. the purpose of this study is to evaluate the clinical utility of a surgeon administered exparel adductor canal block intraoperatively in patients undergoing primary unilateral total knee arthroplasty (tka). patients will not be randomized - all patients will receive an exparel ipsa block intraoperatively. visual analog scale, patient reported outcomes, and patient's satisfaction with pain management will be recorded. adverse events will be monitored.

Eligibility criteria:
inclusion criteria: 1. indicated to undergo primary unilateral total knee arthroplasty under spinal anesthesia. 2. primary indication for tka is degenerative osteoarthritis of the knee. 3. american society of anesthesiologists physical status 1, 2, or 3. 4. able to provide informed consent, adhere to study schedule, and complete all study assessments. 5. body mass index (bmi) \> 18 and \< 40 kg/m2. exclusion criteria: 1. allergy, hypersensitivity, intolerance, or contraindication to any of the study medications for which an alternative is not named in the protocol (e.g., amide-type local anesthetics, opioids, bupivacaine hcl, non-steroidal anti-inflammatory drugs (nsaids)). 2. planned concurrent surgical procedure (e.g., bilateral tka). 3. undergoing unicompartmental tka or revision tka. 4. concurrent painful physical condition (e.g. arthritis, fibromyalgia, cancer) that may require analgesic treatment with nsaids or opioids in the post dosing period for pain that is not strictly related to the knee surgery and which, in the investigator's opinion, may confound the post dosing assessments. 5. previous open knee surgery on the knee being considered for tka. prior arthroscopy is permitted. 6. history of, suspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years. 7. uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, could interfere with study assessments or compliance. 8. currently pregnant, nursing, or planning to become pregnant during the study. 9. clinically significant medical disease that, in the opinion of the investigator, would make participation in a clinical study inappropriate. this includes diabetic neuropathy, coagulation or bleeding disorders, severe peripheral vascular disease, renal insufficiency, hepatic dysfunction or other conditions that would constitute a contraindication to participation in the study. 10. chronic opioid use (average ≥30 oral morphine equivalents/day) within 30 days prior to surgery.
effects of aerobic exercise and core muscle strengthening on pain, menstrual pattern and qol in endometriosis

Conditions: Endometriosis

Summary: endometriosis is a complex and debilitating gynecological condition affecting millions of women worldwide. it is characterized by the abnormal growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain, dysmenorrhea, dyspareunia, and reduced quality of life. while pharmacological interventions are commonly prescribed to manage symptoms, their efficacy may be limited, and they often come with adverse effects. therefore, exploring non-pharmacological approaches, such as exercise, is crucial in improving the management of endometriosis-related symptoms. aerobic exercise has gained attention as a potential therapeutic intervention for endometriosis due to its positive effects on pain modulation, hormonal regulation, and overall well-being.

this randomized controlled trial (rct) will be conducted at jinnah hospital in lahore, pakistan, to investigate the effects of aerobic exercise with and without core muscle strengthening on pain, menstrual pattern, and quality of life in women diagnosed with endometriosis. the study will employ a convenient randomization sampling technique, aiming to recruit approximately 30 participants who meet the inclusion criteria. eligible participants will be reproductive-age women experiencing endometriosis-related pain, with regular menstrual cycles or irregularities associated with endometriosis. they should be medically stable, cleared for physical activity, and willing to participate in an exercise intervention program. exclusion criteria include pregnancy, severe endometriosis-related complications, significant comorbidities, recent surgery, ongoing hormonal treatments targeting endometriosis, inability to participate in exercise programs, and severe mental health conditions. by investigating these interventions, the study seeks to improve symptom management, menstrual regularity, and overall quality of life for women with endometriosis while considering safety and feasibility within the study setting. keywords: endometriosis, menstrual pattern, aerobic exercise, core muscle strengthening, quality of life

Eligibility criteria:
inclusion criteria: * women diagnosed with endometriosis.(16) * age range (e.g., 18-49 years) * regular menstrual cycles or menstrual irregularities associated with endometriosis. * medically stable and cleared for participation in physical activity. * no contraindications for aerobic exercise or core muscle strengthening exclusion criteria: * pregnant individuals or those actively trying to conceive. * recent endometriosis-related surgeries/procedures * use of hormonal therapies/medications targeting endometriosis * severe endometriosis complications requiring immediate medical intervention * inability to engage in aerobic exercise. * significant cardiovascular/respiratory conditions * concurrent participation in another exercise/rehabilitation program

Keywords: endometriosis menstrual pattern aerobic exercise core muscle strengthening quality of life
comparing fluoroscopy and technological methods for guidance during endovascular procedures

Conditions: Aortic Aneurysm, Abdominal

Summary: the investigators want to test a navigation system for guidance during insertion of stent graft in abdominal aortic aneurysms. the navigation system consists of software developed by sintef health, a custom made catheter with a micro position sensor in the tip and an emitter than induces an electromagnetic field around the patient. preoperative ct- and intraoperative dynact- data are reconstructed into 3 dimensional images. the 3 dimensional images are loaded into the navigation system. then the magnetic field, in which the patient finds himself, is calibrated with the 3 dimensional images. when the catheter is inserted into the iliac artery and aorta, the position sensor (in the tip of the catheter) is displayed in real time at the exact anatomic location in the 3 dimensional image. null hypothesis (h0): * insertion of stent graft is performed equally satisfactorily with fluoroscopy alone as with both fluoroscopy and new navigation technology alternative hypothesis (h2): * insertion of stent graft is not performed equally satisfactorily with fluoroscopy alone as with both fluoroscopy and new navigation technology


Eligibility criteria:
inclusion criteria: * aaa with diameter \> 5,0 cm suitable for endovascular technique * normal creatinine * \> 60 years of age exclusion criteria: * known heart failure or unstable coronary disease * other morbidity than normally contraindicates endovascular treatment

Keywords: endovascular aortic repair navigation dynact position sensor
caregiver2, caregiver's health assessment : clinical and biological markers

Conditions: Caregivers

Summary: providing care for a disabled elderly may represent a risk for the health of the caregiver. the objective of the study is to assess the impact of caregiving in terms of clinical and biological markers in relation to disability and cognitive impairment.

the investigators hypothesize that an accumulation of stressful events related to care giving may induce a stress response to the caregiver. this stress response can be measured by biological markers (inflammation, transcription and immunity) and also by clinical markers (frailty, physical performance, nutrition). this stress response can be influenced by the subjective burden of the caregiver and by the severity of the disease of the care receiver (activity of daily life capabilities, cognitive function, behavioral disturbance).

Eligibility criteria:
inclusion criteria: * living with the care-receiver ( or with a healthy elderly for the controls) * care-receiver dependent for at least one activity of the daily living ( katz index) or having cognitive disorder ( \>2 global deterioration scale) exclusion criteria: * institutionalised elderly * inability to understand and speak french * acute disease within the past month * anti-inflammatory or immuno-suppressive treatment * end-of-life care

Keywords: biological marker frailty burden nutrition elderly
effectiveness of 20m-mb in ktr symptom control

Conditions: Transplant;Failure,Kidney

Summary: to study the effectiveness of single session 20-minute mindful breathing in symptom control in kidney transplant recipients.

patients undergoing kidney transplant follow ups in our center are screened based on recruitment criteria. patients who fulfilled the incusion criteria are recruited. intervention involves a 20-minute mindful breathing session with uniform script performed by trained personal, while control arm involves standard care without intervention.

Eligibility criteria:
inclusion criteria: * adult renal transplant patients aged 18 years and older * at least one symptom scoring ≥ 4/10 based on the edmonton symptom assessment scale (esas) exclusion criteria: * dialysis-dependent * medically unstable * having serious pre-existing mental health issues

Keywords: transplant mindfulness mindful breathing
effects of long term antibiotic therapy on exacerbation rate in stable copd patients

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: this study investigates if long term use of the antibiotic doxycycline can reduce exacerbations in copd patients. half of the patients will receive doxycycline which the other half will receive a placebo.

chronic obstructive pulmonary disease (copd) is a common disease which can place a considerable burden on people who suffer from it. copd exacerbations (periods when symptoms flare up) are a major cause of hospital admission in the uk. bacterial infections play an important role in the development of copd and so one possible treatment for copd is with antibiotics. however, there is little information available about the use of long term antibiotics in the treatment of this disease. therefore, the purpose of this study is to investigate if long term use of the antibiotic doxycycline can reduce exacerbations and improve the outlook for these patients.

Eligibility criteria:
inclusion criteria: * informed consent given * confirmed copd diagnosis * severity of disease: patients with a measured fev1\<80% of predicted normal values. * at least one treated exacerbation (patient recalls an episode of symptomatic worsening which was treated and was consistent with a copd exacerbation) in the previous year. * age: ≥ 45 years of age at screening. * able to complete questionnaires for health status and symptoms and considered able to comply with the dosing regimen. * patients willing to report exacerbations and attend for study visits. exclusion criteria: * patients with a known diagnosis of active tb or other chronic respiratory disease in the judgement of the study doctor. * hepatic or renal impairment as defined as lfts \> 5xuln, and egfr\<30 ml/min/1.73m2. * patients with known hypersensitivity to tetracyclines, the imp and/or placebo including their excipients. * patients taking ongoing antibiotic therapy for copd or other conditions. * patients with uncontrolled clinically significant hypertension * female patients who are pregnant or planning on becoming pregnant during the study, or are breastfeeding. * patients with uncontrolled clinically relevant bradycardia, cardiac arrhythmias or cardiac insufficiency. * clinically relevant abnormal electrolyes (sodium or potassium), renal function (urea and creatinine) or liver function (alt, ast, alp) that could interfere with the objectives of the trial or safety of the volunteer. * patient taking clinically significant contraindicated medication, as per the smpc for doxycycline. * use of another experimental investigational medicinal product within 3 months of study enrolment. if the imp used was as part of the nihr wp2 study then entry to wp3 after a 6 week washout period is permissible. * patients with any other condition precluding enrolment in the trial, according to the assessment of the study doctor. this will be documented at screening