Kornimate/medical-research-clean huggingface dataset:
uterine contractions under blue light

Conditions: Preterm Contractions

Summary: the objective in the current study is to test the hypothesis that nocturnal uterine contractions in preterm women can be suppressed by brief ocular exposure to blue light.the olcese lab at florida state university identified a novel interaction between the myometrial melatonin receptors and ot receptors in human myometrial cells (sharkey et al. 2009), which may ultimately help to resolve certain issues surrounding idiopathic preterm labor. their results consistently indicate that melatonin at physiological concentration sensitizes human myometrial smooth muscle cells to the contractile effects of ot (sharkey et al. 2010).

study participants will be pregnant women (gestational weeks 24 to 31+6 days) who present with preterm contractions. in the triage room, the study participant will be connected to the external tocometer from at least 19:00h (7 pm) to the following morning at 07:00h. room lighting will be kept dim. participants meeting inclusion criteria will be randomly allocated to blue light or red light. baseline contractions will be measured. the allocated light mask will be applied for 2 intervals of 60 minutes each.there will be a 60 minute rest period after every 60 minute intervention period for comparison. other than the application of the light mask, all routine standards of care deemed warranted by the obstetric provider for proper treatment of preterm labor will be followed. (ie antenatal steroids, tocolytics).

Eligibility criteria:
inclusion criteria: * pregnant * gestational age: 24 to 31 (+6 days) week of pregnancy * uterine contractions * first episode of preterm labor exclusion criteria: * visual impairment (legally blind) * multiple pregnancy * current progesterone treatment * preeclampsia * renal disease * current chlamydia or gonorrhea infections * cocaine or opiate use * nightshift work in the past week

Keywords: circadian, melatonin, preterm labor
effects of transcranial direct current stimulation in individuals with schizophrenia

Conditions: Schizophrenia

Summary: this research is being done to determine whether transcranial direct current stimulation (tdcs) can improve certain mental abilities and alter functional connectivity in individuals with schizophrenia. in this research, a 9 volt battery is used to deliver very weak electrical current to the surface of the scalp while participants complete cognitive tasks. participants also receive a brain scan before and after stimulation. our aim is to determine if tdcs can improve mental abilities in individuals with schizophrenia.

participants enrolled into this study may be asked to do the following: grant permission for the researchers to view medical records associated with their language/cognitive difficulties complete a questionnaire, provide a health history, and take some pencil-and-paper tests of problem-solving and memory in order to verify eligibility to participate and to able to safely undergo the experimental procedures. complete several tasks (e.g., saying words out loud, naming objects, drawing designs, remembering lists of words, searching for images or letters, and/or completing puzzles) based upon a number of cognitive functions such as language, memory, vision, processing, and perception. wear electrodes that will be placed on the scalp with a large rubberized band. these electrodes will administer very weak electrical current (tdcs) from a 9 volt battery for 20 to 60 minutes. participation in several study conditions. the exact conditions and their order will be randomized. under some conditions, participants may receive active stimulation (tdcs) and under other conditions, they may receive sham stimulation. the experimental sessions will last approximately 2 hours and participants may be asked to have more than one testing session in a day or to return for additional sessions. have a magnetic resonance imaging (mri) brain scan.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia * english as a native language exclusion criteria: * appreciable deficits in hearing or vision * appreciable accent * any implanted metal device or pacemaker * dementia or mini mental exam below 24 * history of seizures

Keywords: schizophrenia cognitive improvement tdcs stimulation
safety and immunogenicity of zostavax vaccine in patients undergoing living donor kidney transplantation

Conditions: Kidney Transplant

Summary: varicella zoster virus is part of the herpesvirus group and causes chickenpox in exposed individuals. the majority of the population is seropositive for this virus. reactivation of varicella zoster virus occurs in up to 30% of the general population over 60 years old. solid organ transplant recipients receive lifelong immunosuppression drugs and are at great risk of reactivation of all herpesviruses including the varicella zoster virus regardless of age. the vaccine has been shown to be effective in preventing shingles in the general population. the investigators' purpose is to determine how well the vaccine works in patients on renal replacement therapy and post-transplant.


Eligibility criteria:
inclusion criteria: 1. age 18-65 years 2. listed or will likely be listed for live donor kidney transplant within one month exclusion criteria: 1. previous receipt of zostavax
after eighty study

Conditions: Coronary Heart Disease

Summary: the rationale of the present clinical trial is to study whether an invasive strategy in clinical stable patients over 80 years with nstemi/uap may improve rates of death, reinfarction, stroke, need of urgent revascularisation, myocardial function and quality of life. the invasive approach involves coronary angiography with immediate evaluation for three different treatment options; 1. percutaneous coronary intervention (pci), 2. coronary artery bypass graft (cabg) or 3. medical treatment. clinical practice shows that older patients are commonly treated less vigorously than younger patients and the present guidelines are based on a considerably younger population.


Eligibility criteria:
inclusion criteria: * age ≥ 80 years. * acute coronary syndrome (nstemi/uap) with chest pain \> 10 minutes, with or without st-segment depression in ecg, and normal or elevated levels of troponin t or i. elevated troponin levels are defined as values exceeding the 99 percentile of a normal population at the local laboratory at each participating site. * clinical stable exclusion criteria: * age \< 80 years. * st-segment elevation in ecg (stemi) * clinical unstable with ongoing chest pain or other ischaemic symptoms/signs. * cardiogenic shock. * short life expectancy due to extra cardiac reason, ie. copd, disseminated malignant disease, or other reason. * anamnestic indications for significant mental disorder, including dementia. * any condition which interferes with patients possibility to comply with protocol.

Keywords: coronary heart disease in patients over 80 years of age.
comparing effects of patient-specific versus non-patient-specific computerized reminder system

Conditions: Radiographic Contrast Agent Nephropathy

Summary: the investigators hypothesize that a clinical decision support system (cdss) designed with "patient-specific" reminders yields superior performance than that with "non-patient-specific" reminders in preventing contrast-induced nephropathy.

we hypothesize that a clinical decision support system (cdss) designed with "patient-specific" reminders yields superior performance than that with "non-patient-specific" reminders in preventing contrast-induced nephropathy. a 3-arm randomized controlled trial (rct) will be performed by cluster randomization using physicians as the unit of allocation. physicians in 3 university medical centers will be randomly assigned into 1) patient-specific arm with anti contrast-induced-nephropathy(anti-cin) reminder, 2) non-patient-specific reminder arm, and 3) the control arm without any reminders, respectively. the patient-specific alert, anti-cin system, is designed as a real-time cdss implementation on cpoe for monitoring physician's contrast-enhanced ct and ivp orders. computerized pop-up reminders provide the patient-specific encounters with optimal decision options when patients are at a high cin risk or patients with unknown risk factors are encountered. non-patient-specific reminders always pop up no matter whether the patient is at a high risk or not.

Eligibility criteria:
inclusion criteria: * our intervention targets are physicians but not patients. all physicians working in the hospital may join this trial. exclusion criteria: * the physician who never orders a ct scan or ivu study will be excluded * the physician who never operates the cpoe by himself or herself will be excluded

Keywords: clinical decision support systems contrast-induced nephropathy
the effect of virtual tour training before orthopedic surgery

Conditions: Anxiety; Satisfaction

Summary: the purpose of the study is to determine the effect of training on surgical environments provided with virtual tour before orthopedic surgical ıntervention on patients' anxiety and satisfaction level.

although preoperative anxiety is accepted as a normal patient response, severe anxiety can lead to a number of negative physiological, emotional and cognitive consequences for patients and ultimately to prolonged hospitalization. if anxiety is not managed effectively in the preoperative period, recovery time is prolonged and the risk of anesthesia and surgery-related complications increases. moreover, it can lead to respiratory distress and cardiac problems. it causes life threats by increasing the risk of bleeding with deterioration in hemodynamic parameters and negatively affects surgical outcomes and patient satisfaction. for all these reasons, this study was designed to contribute to the management of anxiety, which is seen as a problem that needs to be addressed in surgical nursing.

Eligibility criteria:
inclusion criteria: * between the ages of 18-65 * being literate * no comprehension and perception problems * no hearing and vision problems * not being under psychiatric treatment * no surgical experience * to undergo elective orthopedic surgery in the operating room * acceptance to participate in the research exclusion criteria: * to undergo emergency orthopedic surgery * wishing to leave at any stage of the study

Keywords: anxiety satisfaction virtual reality orthopedic surgical procedures
intestinal failure, multiple organ failure and citrulline assessment

Conditions: Citrulline; Organ Failure, Multiple; Gastro Intestinal Failure; Intra Abdominal Pressure

Summary: the gastrointestinal dysfunction occurs frequently during the intensive care unit (icu) stay and is associated with a worse prognosis. the gastrointestinal failure (gif) is diagnosed based on symptoms such as bowel distension, ileus, diarrhea, digestive bleeding, or intestinal ischemia. a gif score based on has been demonstrated to be correlated with outcome, with higher scores indicating higher risk of death. however, gif may be occult or clinical signs can go undetected in critically ill patients due to the frequent use of analgesic, sedative or neuromuscular blocking agents, acute neurologic diseases, or delirium. citrulline is a potential biomarker for small bowel function in critically ill patients with maintained renal function. normal plasma citrulline levels (12-55 µmol/l) are determined by the balance between gut synthesis and kidney degradation. gif is involved in the pathogenesis of multiple organ dysfunctions and failures (mof) through various mechanisms, and it is often associated with high intra-abdominal pressure (iap). iap greater than 12 mmhg, may lead to abdominal compartment syndrome (acs) and mof, including cardiac, respiratory and kidney failure. studies have suggested that gif can be the consequence rather than the cause of mof. the aim of this study is to investigate if plasma citrulline levels is associated with a clinical diagnosis of gif, and may predict the development of mof.


Eligibility criteria:
inclusion criteria: - intensive care unit stay of at least 48 hours exclusion criteria: * intensive care unit stay less than 48 hours * abdominal trauma or surgery in the last 6 weeks * inflammatory bowel disease * a body mass index (bmi) ≥35 * terminal condition.

Keywords: citrulline gif mof calprotectina intraabdominal pressure
the effects of scalp block with bupivacaine versus levobupivacaine

Conditions: Hypertension

Summary: ninety american society of anesthesiologists (asa) physical status classification system i-ii patients were recruited for a randomised, placebo-controlled, double-blind study and were randomly divided into three groups to receive either 20 ml of 0.5% bupivacaine (group b; n=30), 20 ml of 0.5% levobupivacaine (group l; n=30) or saline as a placebo (group c; n=30). scalp block was performed 5 min before head pinning. the primary outcome of the study was mean arterial pressure (map) and secondary outcomes were heart rate (hr), visual analogue scale (vas) scores, additional intraoperative and postoperative drug use. postoperative pain was evaluated using a 10-cm visual analogue scale (vas).

following approval from the research ethics committee of the medical faculty of uludağ university, (the date and protocol number assigned by this ethics committee were march 4, 2008 and 5/30, respectively),written informed consent was obtained from patients undergoing elective scheduled operations involving craniotomy during anaesthesia consultations. ninety american society of anesthesiologists (asa) physical status classification system i or ii patients of either sex between 18-85 years of age were allocated to this randomised, prospective, placebo-controlled, double-blind study. the patients were randomly divided into three groups using a sealed-enveloped technique to receive either 20 ml of 0.5% bupivacaine (group b (n=30)), 20 ml of 0.5% levobupivacaine (group l (n=30)) or saline as a placebo (group c (n=30)). twenty-millilitre syringes for the block were prepared and numbered by a blinded assistant.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status classification system 1-2 exclusion criteria: * uncontrolled hypertension, arrhythmia, diabetes mellitus or coagulopathy, coronary artery disease or a proven or suspected allergy to bupivacaine or levobupivacaine

Keywords: anaesthesia local anaesthesia hemodynamics bupivacaine levobupivacaine
chronic dorzagliatin on insulin and incretin function in intermediate hyperglycemia and type 2 diabetes

Conditions: Diabetes Mellitus; Prediabetes / Type 2 Diabetes

Summary: a total of 30 subjects will be recruited 15 with intermediate hyperglycemia and 15 in the tyep 2 diabetes group respectively. eligible participants will undergo hyperglycemic-clamp/oral glucose tolerance at baseline and after 4 weeks of dorzagliatin treatment.


Eligibility criteria:
inclusion criteria: 1. individuals aged ≥ 18 years but \< 70 years 2. male or female 3. body mass index of over 18 kg/m2 and \< 35 kg/m2 additional inclusion criteria for ih group * fasting plasma glucose \<7.0 mmol/l and hba1c \< 6.5% * 1 hour plasma glucose ≥8.6 and \<11.6 mmol/l on 75g oral glucose tolerance test (ogtt) * no use of glucose lowering drugs in past 6 months additional inclusion criteria for t2d group * hba1c 6.5 to 10% at screening * on diet control, or stable dose of oral glucose lowering drugs metformin for at least 8 weeks exclusion criteria: * 1. subjects who do not agree to participate in this study. 2. country of birth is unknown. 3. body weight less than 45kg. 4. acute phase of cerebrovascular and cardiovascular diseases (within 6 months of recruitment). 5. subjects with severe renal dysfunction as defined by egfr \<30 ml/min/1.73m2 or patients receiving renal dialysis (such as haemodialysis or continuous ambulatory peritoneal dialysis). 6. severe hepatic dysfunction as defined by aspartate aminotransferase (ast) and/or alanine aminotransferase (alt) \> 3 times upper limit of normal. 7. severe cardiovascular disease, history of stroke, heart failure (nyha iii or iv) or history of myocardial infarction within last 12 months. 8. history of drug abuse or excessive alcohol intake based on investigator judgment. 9. dehydration, diarrhoea or vomiting at the time of recruitment. 10. subjects with severe infection, in perioperative period or with serious injury at the time of recruitment. 11. subjects with anaemia (haemoglobin \<9.0mg/dl). 12. pregnant or lactating or intending to become pregnant within 30 days after last dose of study drug. 13. participation in a clinical trial with investigational product within 30 days before enrolment. 14. donation or loss of blood (excluding the volume of blood that will be drawn during screening procedures) as follows: ≥300 ml of blood within 30 days prior to study drug administration. 15. subjects judged unsuitable for the study based on investigator judgment. 16. use of strong or moderate cyp3a4 inhibitors or inducers and cannot be discontinued. 17. unwilling or unable to follow protocol requirements.

Keywords: clamp diabetes glucokinase activator
penile nerve stimulation for treatment of delayed ejaculation

Conditions: Delayed Ejaculation

Summary: the aim of this clinical trial is to test the safety and feasibility of using transcutaneous electrical nerve stimulation (tens) of the penile nerves to reduce intra-vaginal ejaculatory latency time in men with delayed ejaculation (de). we hypothesize that this type of stimulation, either before or during sexual activity, will reduce latency time. the primary objective of this study is to determine if tens of the penile nerve helps men with de subjectively reduce their ejaculatory latency time. the secondary objective is to determine whether their international index of erectile function (iief) score improves with treatment.


Eligibility criteria:
inclusion criteria: * 18 years or older * sexually active * diagnosed with delayed ejaculation exclusion criteria: * less than 18 years old * any condition effecting the participant that would make them unable to operate the interventional device
preventing hypotension in parturients with an elevated body mass index (bmi)

Conditions: Hypotension

Summary: previous research regarding the use of phenylephrine has excluded obese subjects (bmi \>35). this subgroup of patients represents a large portion of the obstetric patient population locally and nationally. it is unclear whether previous research should be extrapolated to the obese patient population. this study is being done to compare the incidence of hypotension, intraoperative nausea and vomiting, and neonatal acidosis between obese patients who receive a prophylactic phenylephrine infusion versus those who receive phenylephrine boluses for the treatment of established hypotension. this study will help us determine whether using a phenylephrine infusion or a phenylephrine bolus is the best way to prevent/treat spinal induced hypotension during cesarean deliveries in obese patients.


Eligibility criteria:
inclusion criteria: * english speaking * asa physical status i-ii * non-laboring women * single gestations ≥ 36 weeks * obese women (body mass index 35 - 55 kg/m2) * non-emergent cd under spinal anesthesia exclusion criteria: * height \< 5'0" * antiemetic drug use in the 24 hours prior to cd * allergy to phenylephrine, or any other standardized medication * hypertensive disease of pregnancy (i.e. mild \& severe preeclampsia) * chronic hypertension receiving antihypertensive treatment * severe cardiac disease in pregnancy with marked functional limitations * patients on monoamine oxidase inhibitors or tricyclic antidepressants * subject enrollment in another study involving a study medication within 30 days of cd * any other physical or psychiatric condition which may impair their ability to cooperate with study data collection

Keywords: spinal induced hypotension nausea and vomiting cesarean delivery
prospective assessment of meos telemedicine e-portal on ambulatory care of type 1 diabetic patients

Conditions: Diabetes Mellitus, Type 1

Summary: primary objective of telediab-3 study is to demonstrate that the use of meos telemedicine eportal for sharing information between diabetologist and type 1 diabetic patient is not inferior to a conventional care regarding metabolic results at 12 months.

meos is the name of the website (telemedicine eportal) tested in this trial ; it is used to share informations between diabetologist and type 1 diabetic patients.

Eligibility criteria:
inclusion criteria: * patient with type 1 diabetes mellitus for ≥ 12 months or more * age \> 18 years old * patient who is followed since 6 month into investigator hospital * patient with available internet access at least once a week, and ability to understand meos website navigation * patient using a compatible glucose meter (one touch ultra, optium xceed, or bg star) exclusion criteria: * patient with no easy and regular access to the internet; * patient found to be unfit for use of the telematic tools or e-mail tools * patient with toxicomania, alcoholism or psychological troubles * type 2 diabetic patients * patient who does not need strict metabolic objectives * pregnant or parturient women * person with no freedom (prisoner)

Keywords: telemedicine type 1 diabetes economic cost of type 1 diabetes eportal meos
medical imaging in bladder tumors by mri

Conditions: Bladder Tumor; Magnetic Resonance Imaging

Summary: this study prospectively included 178 patients with bladder neoplastic lesions who planned to undergo surgery (with or without preoperative neoadjuvant chemotherapy). inclusion criteria: patients with pathologically confirmed bladder cancer after radical or partial cystectomy or turbt (\ 2 weeks; 4) obvious artifacts; 5)mri scan contraindications. all subjects underwent pelvic mri. data was collected using a siemens vida 3tmr scanner (siemens healthcare, erlangen, germany). all subjects underwent standardized scanning protocols. the obtained images are post-processed and the experimental results are analyzed statistically.


Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of bladder neoplasm 2. must undergo radical or partial cystectomy or turbt surgery within 2 weeks between surgical resection and imaging exclusion criteria: 1. a history of pelvic radiotherapy or chemotherapy; 2. lack of pathological findings or no surgery; 3. the interval between surgical resection and imaging examination \> 2 weeks; 4. poor image quality due to poor coordination or motion artifacts; 5. mri scan contraindications
progress complication

Conditions: Coronary Artery Disease

Summary: coronary angiography and percutaneous coronary intervention (pci) is often performed in patients with ischemic heart disease. the safety of pci has improved with new devices and strategies, but complications still occur, especially during complex procedures. the objectives of this multi-center observational registry are to examine frequency of complications occuring during cardiac catheterization and pci, examine procedural strategies utilized for complication management, and evaluate the clinical outcomes (both immediate and during follow-up.)

the safety of pci has improved with new devices and strategies, but complications still occur, especially during complex procedures. systematic study of cardiac procedure complications can improve procedural safety and optimize short and long-term patient outcomes. the objectives of this multi-center observational registry are to 1-examine the frequency and types of complications occurring during cardiac catheterization and pci among participating sites, 2-examine the procedural strategies (techniques and devices) utilized for complication management, 3-evaluate the clinical outcomes (both immediate and during follow-up) after each complication type.

Eligibility criteria:
* over 18 years of age * undergoing coronary angiography or pci * a complication occurred during or after the procedure

Keywords: complications percutaneous coronary intervention