Kornimate/medical-research-clean huggingface dataset:
effects of laugh therapy associated to cardiopulmonary rehab

Conditions: Ischemic Heart Disease

Summary: laugh is more than visual and vocal behave, is always followed by a series of physiological changes, including contractions of musculoskeletal system, increase of cardiac frequency by catecholamine release and hyperventilation that promoves the increase of maximum breathing and oxygen saturation. laugh therapy may be an alternative therapy, simple, and improve the quality of life of individuals can influence physiological and biochemical parameters of the human body.

methods: randomized clinical trial with patients from outpatient ischemic heart disease of the hospital de clínicas de porto alegre , patients of both sexes in all regular monitoring. all patients will perform 30 minutes of stretching before film sessions. the exercises will be mild to moderate (modified borg scale between 3 and 6).

Eligibility criteria:
inclusion criteria: * ischemic heart disease diagnosis established by cardiac catheterization, with 50% lesion in at least one epicardial vessel (if the patient has had an acute coronary syndrome or have been revascularized, the event time is expected to exceed 6 months). * both sexes * with availability to come to hcpa twice a week * in conditions of entering into a cardiac rehabilitation program with exercise. exclusion criteria: * involvement in another clinical trial. * presence of autoimmune disease * use of oral anticoagulant * valvulopathy with mechanical or biological cardiac prosthesis * presence pacemaker or implantable cardioverter * left bundle branch block in 12-lead ecg * severe lung disease * major depression or bipolar disorder * chronic atrial fibrillation * left ventricular dysfunction (ejection fraction \<45%) * active infection or cancer (other than basal cell carcinoma) * chronic renal failure * illiteracy * inability to understand the consent form

Keywords: ischemic heart disease laugh therapy
koning breast computed tomography guided biopsy

Conditions: Breast Cancer

Summary: the primary aim of this study is to show that the accuracy of koning breast ct-guided biopsy is at least equivalent to that of stereotactic-guided biopsy.


Eligibility criteria:
inclusion criteria: * female at least 35 years of age of any ethnicity * lesion seen on mammography * diagnostic report read as bi-rads 4 or 5 * will undergo biopsy no later than four weeks from date of mammogram * is able to undergo informed consent exclusion criteria: * pregnancy * lactation * subjects with breast implants * subjects with physical limitations that may prohibit resting prone on the exam table, such as, but not limited to: frozen shoulder, recent heart surgery, pacemaker. * subjects who are unable to tolerate study constraints. * subjects who have received radiation treatments to the thorax for malignant and nonmalignant conditions, such as (but not limited to) * treatment for enlarged thymus gland as an infant * irradiation for benign breast conditions, including breast inflammation after giving birth * treatment for hodgkins disease * subjects who have participated in a prior breast clinical trial that gave additional radiation dose, such as an additional mammogram. * subjects who have received large numbers of diagnostic x-ray examinations for monitoring of disease such as (but not limited to) * tuberculosis * severe scoliosis

Keywords: breast ct biopsy
efficacy of play therapy for the reduction of perioperative anxiety in pediatric patients

Conditions: Perioperative Anxiety

Summary: the goal of this randomized controlled clinical trial was to determine the efficacy of play therapy in reducing perioperative anxiety in pediatric patients aged 3 to 6 years undergoing inguinal hernia surgery. the main research question was: was play therapy effective in reducing perioperative anxiety levels in pediatric patients undergoing inguinal hernia repair? primary outcome measure: anxiety level. patients were randomized into two groups: 1. an intervention group, which received play therapy involving a transport cart and toys; and 2. a control group, which received anxiolytic medication and standard care. researchers compared the control group and the play therapy group to evaluate differences in anxiety levels using the visual analog scale for parents (vas-p) and the modified yale preoperative anxiety scale-short form (mypas-sf).

design and study population: a randomized controlled clinical trial with parallel groups was conducted involving pediatric patients aged 3 to 6 years who were scheduled for inguinal hernia repair at dr. juan i. menchaca civil hospital in guadalajara, mexico. participants were randomly assigned to one of two groups: the play therapy group or the control group. the play therapy group received a play-based intervention using toys. after five minutes of playing with a transport cart, the children were transported to the operating room in the same cart. the control group received oral midazolam (0.1 mg/kg). after five minutes, they were transferred to the operating room either in a caregiver's arms or on a standard stretcher. the study was approved by the ethics and research committees (60/hcjim-jal/2023). assessment and management of anxiety: perioperative anxiety was assessed using two instruments: the modified yale preoperative anxiety scale-short form (mypas-sf), completed by the anesthesiologist. the visual analog scale for parents (vas-p), which measured anxiety as perceived by the child's parent or guardian.both instruments were applied at three time points: 1. upon initial contact with the anesthesiologist 2. after the intervention (play-based or pharmacological) 3. upon arrival in the operating room additionally, midazolam was administered as rescue therapy for any patient exhibiting significant anxiety (mypas-sf score \> 30 following the intervention).

Eligibility criteria:
inclusion criteria: * pediatric patients aged 3 to 6 years. * patients of any sex. * patients scheduled for elective inguinal hernioplasty. * patients undergoing their first anesthetic-surgical procedure. * patients whose legal guardian provided informed consent. exclusion criteria: * patients with known allergy to midazolam. * patients with abnormal perinatal history (e.g., neonatal hypoxia or chromosomal abnormalities). * patients undergoing emergency inguinal hernioplasty due to complications such as strangulation or incarceration.

Keywords: pediatric surgery anxiety assessment herniorrhaphy play therapy perioperative anxiety
study of the effects of dopaminergic medications on dopamine transporter imaging in parkinson's disease

Conditions: Parkinson Disease; Parkinsonian Syndrome

Summary: study participants who have been clinically diagnosed with parkinson disease will receive no treatment, treatment with either levodopa, or treatment with mirapex for a period of 12 weeks. over the course of the study subjects will travel to the institute for neurodegenerative disorders (ind) in new haven, connecticut for brain imaging.

brain imaging will be conducted three times during this study. study participants will travel to ind for \[123i\]ß-cit and spect imaging (scan 1). subjects will be randomized to no treatment, treatment with either levodopa, or treatment with mirapex and undergo treatment for a period of 12 weeks. subjects will return to ind for \[123i\]ß-cit and spect imaging (scan 2) after 12 weeks of treatment and withdraw from the medication following the scan. eight to 12 weeks after medication withdrawal, a final \[123i\]ß-cit and spect imaging study (scan 3) will be performed at ind. the imaging outcome, striatal uptake of \[123i\]ß-cit, from scan 1 (untreated) and scan 2 (treated with levodopa or pramipexole) will be compared to determine if there is a significant change in the uptake of the marker that may be attributed to levodopa or pramipexole treatment. in addition, scan 3 will be compared to scan 2 to determine the duration and reversibility of any regulatory effect that occurs. the subjects will be randomized, but not blinded to study drug assignment. the imaging technologist and all imaging analyses will be performed by investigators blinded to study drug assignment.

Eligibility criteria:
inclusion criteria: * 30 years or older at time of parkinson disease (pd) diagnosis * clinical diagnosis of pd of equal to or less than 7.5 years * normal laboratory screening exclusion criteria: * participant is pregnant * participant has atypical or drug induced pd * participant has significant dementia

Keywords: parkinson brain imaging diagnosis
feasibility study for treating trichotillomania with wearable device and app system

Conditions: Trichotillomania

Summary: trichotillomania is characterized by recurrent hair pulling resulting in hair loss causing significant distress and impairment which persists despite repeated attempts to stop. behavioral based therapies focused on increasing awareness of hair pulling followed by the use of an incompatible behavior have proven effective. in an effort to enhance awareness, a wrist worn motion detection device was created. in this study, we will test the feasibility of the habitaware device and accompanying app as a system for delivering self-administered habit reversal training (hrt).


Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. speak fluent english 3. current diagnosis of ttm 4. score above the normative mean on the automatic pulling subscale of the mist-a 5. not on psychotropic medication or on a stable dose (i.e., same dose for past 6 weeks) exclusion criteria: 1. currently receiving psychotherapy 2. other psychiatric condition requiring more immediate care 3. have previously used any behavior awareness devices (e.g. keen)

Keywords: hair pulling disorder body-focused repetitive behaviors trichotillomania
a study on association between hr genes and the hrd status in chinese epithelial ovarian cancer

Conditions: Epithelial Ovarian Cancer; Chinese; Homologous Recombination Deficiency; BRCA1 Mutation; BRCA2 Mutation; Prognosis; Homologous Recombination Genes

Summary: the association between homologous recombination (hr) gene mutations and homologous recombination deficiency (hrd) status in chinese epithelial ovarian cancer (eoc) patients is little known. this study would recruit 400 chinese eoc patients with known targeted gene mutations via a multi-panel testing of 27 genes, including brca1/brca2. all patients accept evaluation of hrd model, which is based on the loss of heterozygosity (loh), telomere allele imbalance (tai) and large-scale state transitions (lst). the mutated genes, hrd score model and their relationship with the prognosis, would provide a full description of for the chinese eoc patients, and a potential explanation of platinum-resistance in such population.


Eligibility criteria:
inclusion criteria: * aged 18 years or older * pathological confirmation of epithelial ovarian cancer * with available tumor tissues * given consents to participate the study exclusion criteria: * not meeting all of the inclusion criteria
impact of visceral manipulation versus integrated neuromuscular inhibition technique in shoulder impingement syndrome

Conditions: Shoulder Impingement

Summary: this study will be conducted to evaluate the effect of visceral manipulation versus integrated neuromuscular inhibition technique on the upper fiber of trapezius on pain intensity, pain threshold, shoulder range of motion, and function in shoulder impingement syndrome

hypotheses it will be hypothesized that: 1. there will be no statistically significant effect of visceral manipulation on the upper fiber of the trapezius on pain intensity, pain threshold, shoulder range of motion, or function in shoulder impingement syndrome 2. there will be no statistically significant effect of the integrated neuromuscular inhibition technique on the upper fiber of the trapezius on pain intensity, pain threshold, shoulder range of motion, or function in shoulder impingement syndrome. 3. there will be no statistically significant difference in the effect of visceral manipulation versus the integrated neuromuscular inhibition technique on the upper fiber of the trapezius on pain intensity, pain threshold, shoulder range of motion, and function in shoulder impingement syndrome. this study will be conducted to answer the following questions: is there an effect of visceral manipulation versus integrated neuromuscular inhibition technique on the upper fiber of the trapezius on pain intensity, pain threshold, shoulder range of motion, and function in shoulder impingement syndrome?

Eligibility criteria:
inclusion criteria: * -active myofascial trigger points in the upper trapezius muscle, and chronic pain lasting more than 12 weeks * bmi between 25 and 30 kg/m². exclusion criteria: * a previous fracture in the cervical spine or shoulder surgery * acute inflammatory condition. * malignant tumor. * multiple osteophytes. * cervical posture abnormalities. * osteoporosis.
comparative effects of muscle energy technique and routine physical therapy on quadratus lumborum in patients with chronic low back pain

Conditions: Chronic Low-back Pain

Summary: •null hypothesis: there is no difference in effects of muscle energy technique and routine physical therapy on quadratus lumborum in patients with chronic low back pain. •alternative hypothesis: there is difference in effects of muscle energy technique and routine physical therapy on quadratus lumborum in patients with chronic low back pain.

the purpose of the study is to compare the effects of muscle energy technique and routine physical therapy on quadratus lumborum in patients with chronic low back pain on pain, range of motion, quality of life and functional disability. the study procedure will be explained to the patients and informed written consent will be obtained from those patients who will be willing to participate in the study. quadratus lumborum tightness will be assessed using side bending test. those fulfilling the requirement of inclusion criteria will be indiscriminately separated into 2 groups. nprs, oswestry disability index, sf-20 and goniometer will be used to collect data. total 68 participants will be recruited in the study. routine physical therapy will be provided to group a. reciprocal inhibition muscle energy technique on quadratus lumborum along with routine physical therapy will be performed on group b. both group will receive interventions three sessions in a week for 4 consecutive weeks. assessment of pain, range of motion, quality of life and functional disability will be assessed by using goniometer, nprs, oswestry disability index and sf-20 questionnaire respectively for both groups at the baseline, end of 6th session (2nd week) and end of 12th session (4th week) and follow up will be obtained after 1 month (8th week).

Eligibility criteria:
inclusion criteria: * both genders of age 30 to 55 year. * patients with pain for at least three months or more (chronic stage). * patients having score of at least 3 on 0-10 points(nprs). * diagnosed patients of low back pain. * non-radicular low back pain. * quadratus lumborum tightness by physical test i.e. side bending test. exclusion criteria: * pregnant females. * lumbar radiculopathy. * any spinal pathology i.e. infectious disease and fracture. * any congenital deformity of spine, upper and lower extremities. * systemic illnesses i.e. cardiovascular disorders, respiratory disorders etc. * history of surgery of hip, pelvis, lumbar spine, disc herniation.

Keywords: low back pain lumbar pain backache muscle energy technique quadratus lumborum
trial of pde4 inhibition with roflumilast for the management of atopic dermatitis (integument-ped)

Conditions: Atopic Dermatitis Eczema

Summary: this study will assess the safety and efficacy of arq-151 cream vs vehicle applied once a day for 4 weeks by subjects with atopic dermatitis (eczema).

this is a parallel group, double blind, vehicle-controlled study in which arq-151 cream or vehicle is applied once daily for 4 weeks to subjects with atopic dermatitis.

Eligibility criteria:
inclusion criteria: 1. informed consent by parent(s) or legal guardian as required by local laws. 2. males and females, ages 2 to 5 years old at time of signing informed consent (screening) and at baseline (day 1). 3. diagnosed with atopic dermatitis for at least 6 weeks, as determined by the investigator. stable disease for the past 4 weeks with no significant flares in atopic dermatitis before screening. 4. in good health as judged by the investigator. 5. subjects considered reliable and capable of adhering to the protocol and visit schedule, according to the judgment of the investigator. exclusion criteria: 1. subjects with any serious medical condition or clinically significant abnormality that would prevent study participation or place the subject at significant risk, as judged by the investigator 2. has unstable ad or any consistent requirement for high potency topical steroids. 3. subjects who are unwilling to refrain from prolonged sun exposure for 4 weeks prior to baseline/day 1 and during the study. 4. previous treatment with arq-151. 5. parent(s)/legal guardian(s) who are unable to communicate, read, or understand the local language(s). subjects who are unable to communicate, read or understand the local language, or who display another condition, which in the investigator's opinion, makes them unsuitable for clinical study participation. 6. subjects who are family members of the clinical study site, clinical study staff, or sponsor, or family members of enrolled (in other studies of arq-151) subjects living in the same house.
lay-led smoking cessation approach for southeast asian men

Conditions: Cardiovascular Diseases; Heart Diseases; Lung Diseases, Obstructive; Chronic Obstructive Pulmonary Disease

Summary: to develop a scientifically valid and ethnically approved, lay-led smoking cessation intervention for southeast asian men and women, i-e., those from cambodia, laos, and vietnam.

background: economically disadvantaged southeast asian men were targeted because of their higher than average smoking prevalence rate, their extraordinary increased numbers, and the relative paucity of strategies to reach this hard-to-reach group. design narrative: trained, lay s.e. asian counselors (cadre) were the primary agents for this study's assessment, intervention, and follow -up of smoking cessation behaviors. seven reasons for using this approach were cited, including the potential generalization of this approach to other populations. over the six year demonstration and education research study period, the investigators: collected baseline data on smoking and smoking cessation behaviors; designed ethnically approved strategies for the cessation and maintenance of smoking cessation behaviors based upon findings from the baseline assessment; implemented ethnically approved strategies for smoking cessation; maintained smoking cessation after initial quitting; and evaluated the effectiveness of the intervention. on the macro level, an equal number of randomly selected subjects (e1) allocated equally among the three ethnic groups in one county were compared to an equal number of control subjects in geographically separate counties. on the micro level, e1 subjects were also compared to control subjects (c1) in the intervention county. all subjects were longitudinally followed. the standard for successful cessation was biochemically verified through salivary cotinine tests at one year of self-reported abstinence. among the study's features were the community-based (versus academic or clinical) nature of lay change agents, the deliberate integration of baseline data and scientific principles with ethnic values in the intervention approach, and a research design that allowed for both macro and micro comparisons of the intervention with control conditions.

Eligibility criteria:
no eligibility criteria
ranibizumab versus aflibercept for crvo in young patients.

Conditions: Non-Ischemic Central Retinal Vein Occlusion With Macular Edema

Summary: this study will compare the efficacy and safety of use either ranibizumab and aflibercept in treatment of macular edema resulting from non ischemic central retinal vein occlusion in patients younger than 5o years old

this is a prospective randomized interventional study, forty eyes of forty patients younger than 50 years with macular edema due to non-ischemic crvo were enrolled in the study. patients will be randomized into 2 groups. first group will receive intravitreal injection of ranibizumab 0.5 mg\\0.1ml. the second group will receive intravitreal injection of 2.0 mg\\0.1 ml aflibercept. all patients will be followed up for 12 months.

Eligibility criteria:
inclusion criteria: * patients younger than 50 years with macular edema due to non-ischemic crvo exclusion criteria: other conditions that might affect the macula as 1. diabetic retinopathy, intraocular inflammation, age related macular degeneration, patients with solar or radiation retinopathy, 2. patients with ischemic type crvo and patients who had recent intraocular surgery. 3. patients who had previous intravitreal injections, ophthalmic laser surgeries. 4. patients with dense cataracts whom fundus was difficult to scan. 5. patients who were lost to follow up visits were also excluded

Keywords: non ischemic crvo macular edema ranibizumab aflibercept
deep learning for fluorescein angiography and optical coherence tomography macular thickness map image translation

Conditions: Eye Diseases; Diabetic Retinopathy

Summary: diabetic macular edema (dme) is one of the leading causes of visual impairment in patients with diabetes. fluorescein angiography (fa) plays an important role in diabetic retinopathy (dr) staging and evaluation of retinal vasculature. however, fa is an invasive technique and does not permit the precise visualization of the retinal vasculature. optical coherence tomography (oct) is a non-invasive technique that has become popular in diagnosing and monitoring dr and its laser, medical, and surgical treatment. it provides a quantitative assessment of retinal thickness and location of edema in the macula. automated oct retinal thickness maps are routinely used in monitoring dme and its response to treatment. however, standard oct provides only structural information and therefore does not delineate blood flow within the retinal vasculature. by combining the physiological information in fa with the structural information in the oct, zones of leakage can be correlated to structural changes in the retina for better evaluation and monitoring of the response of dme to different treatment modalities. the occasional unavailability of either imaging modality may impair decision-making during the follow-up of patients with dme. the problem of medical data generation particularly images has been of great interest, and as such, it has been deeply studied in recent years especially with the advent of deep convolutional neural networks(dcnn), which are progressively becoming the standard approach in most machine learning tasks such as pattern recognition and image classification. generative adversarial networks (gans) are neural network models in which a generation and a discrimination networks are trained simultaneously. integrated network performance effectively generates new plausible image samples. the aim of this work is to assess the efficacy of a gan implementing pix2pix image translation for original fa to synthetic oct color-coded macular thickness map image translation and the reverse (from original oct color-coded macular thickness map to synthetic fa image translation).


Eligibility criteria:
inclusion criteria: * patients from the retina clinic in assiut university hospital who had simultaneously undergone same-day fa and oct with a diagnosis of confirmed or suspected dme. exclusion criteria: * significant media opacity that obscured the view of the fundus * oct images with high signal-to-noise ratio expressed by the device as"topq image quality," below 60 * vitreoretinal interface disease distorting the oct thickness map. * patients with concurrent ocular conditions interfering with blood flow * patients with uveitic diseases * high myopia of more than -8.0 diopters.