Kornimate/medical-research-clean huggingface dataset:
pain evaluation and treatment in the emergency department

Conditions: Pain, Acute; Emergencies

Summary: all patients admitted in geneva university hospitals (guh) emergency department (ed) are triaged using the swiss emergency triage scale (sets), a 4-level symptom-based triage scale. at the end of the triage process the triage nurse has to choose an emergency level and a main presenting complaint among a listing of 98 presenting complaints. the sets recommends a pain evaluation for 44 out of the sets 98 presenting complaint. the primary objective of the study is to determine whether pain is correctly evaluated when required by the sets criteria. the secondary objectives are (1) to evaluate whether an appropriate treatment is delivered when pain is present, and (2) to identify predictors of pain evaluation and treatment.

all patients admitted in geneva university hospitals (guh) emergency department (ed) are triaged using the swiss emergency triage scale (sets), a 4-level symptom-based triage scale. at the end of the triage process the triage nurse has to choose an emergency level and a main presenting complaint among a listing of 98 presenting complaints. the sets recommends a pain evaluation for 44 out of the sets 98 presenting complaint. after this evaluation, a protocol standardize administration of analgesia for patients presenting pain. the primary objective of the study is to determine whether pain is correctly evaluated when required by the sets criteria for the 44 presenting complaints. the secondary objectives are (1) to evaluate whether an appropriate treatment is delivered when pain is present, and (2) to identify predictors of pain evaluation and treatment.

Eligibility criteria:
inclusion criteria: * adult (\>= 16y) patients admitted at guh ed during one year * presenting complaint requiring pain evaluation accordingly to the sets criteria exclusion criteria: * \< 16 y * presenting complaint that does not require a pain evaluation accordingly to the sets criteria

Keywords: triage
social acceptability of covid-19 vaccines in pakistan

Conditions: Social Acceptance, Social Anxiety

Summary: social settings of pakistan is unique in the sense that it is composed of multilingual, multicultural and different ethnicities. also their believes and faiths are so unpredictable. it is therefore observed that this social phenomenon affects the acceptability of new things in this area. polio vaccination has not worked so well in the past. iodized salt acceptability has also been criticized in the last decades and is a matter of controversy till now. this behavior has also developed before the commencement of vaccination of covid-19 in pakistan, as there are many rumors and fears circulating via social media amongst pakistan. what will be the acceptance rate for this vaccination, the time will decide.


Eligibility criteria:
inclusion criteria: * adult * cooperative * willing to participate in study * pakistani citizen exclusion criteria: * minors * non-cooperative/unconconcious * non-citizen of pakistan

Keywords: acceptance anxiety fear social behavior
the effect of feeding length on the oxygenation instability among premature infants

Conditions: Premature Infant; Respiratory Disease

Summary: spo2 instability is in the nature of premature infants. hypoxic episodes occur spontaneously in many of these infants, especially after the first week of life. different interventions have been shown to influence the incidence of hypoxemic episodes in premature infants. premature infants are fed via an ng/og tube. feeding length might influence the oxygenation instability among premature infants therefore the aim of this study is to evaluate the changes in oxygenation among preterm infants receiving respiratory support when are fed over 30 min vs over 2 hours, as documented by spo2 histograms.


Eligibility criteria:
inclusion criteria: premature infants (ga\ 100 ml/kg/day exclusion criteria: congenital anomalies e.g. gastroschesis, congenital diaphragmatic hernia, cyanotic heart disease. instability because of: acute lung pathology for example x-ray confirmed pneumonia, air leak active culture proven sepsis need for inotropic support for low blood pressure
prospective study on intensive early rheumatoid arthritis treatment

Conditions: Rheumatoid Arthritis

Summary: hypothesis: early intensive treatment with anti-tnf agent plus methotrexate plus high dose prednisone may increase remission rate and may induce stable remission in rheumatoid arthritis objective: to evaluate induction of remission using adalimumab, prednisone and methotrexate and maintenance of remission after discontinuation of adalimumab and prednisone

treatment group a 0 - 6 months: adalimumab 40 mg eow + methotrexate rapidly titrated to 20 mg weekly + prednisone 50 mg/d tapered to 6.25 mg 6 - 12 months: adalimumab 40 mg eow plus methotrexate 20 mg weekly group b 0 - 6 months: adalimumab 40 mg eow + methotrexate rapidly titrated to 20 mg weekly + placebo 6 - 12 months: adalimumab 40 mg eow + methotrexate rapidly titrated to 20 mg weekly follow up period - open label phase: patients achieving clinical remission will be than treated only with mtx and observed for another 12 months period. patients who do not achieve clinical remission or patients who will experience a relapse of the disease will be treated according to standard of care (soc) modalities.

Eligibility criteria:
inclusion criteria: * active rheumatoid arthritis diagnosed for at least 6 weeks, but no more than 1 year, according to the revised 1987 acr criteria * naïve to treatment with mtx * swollen joint count (sjc) \> 8 tender joint count (tjc) \> 8 * at screening crp \> 1.5 mg/dl (15 mg/l) or esr ≥ 28 mm/h * ≥ 1 joint erosion or rf positivity or anti-ccp positivity * age 18-70 years. exclusion criteria: * rheumatic autoimmune disease other than ra * functional class iv * any surgical procedure within 12 weeks prior to baseline or planned during the study. * pregnancy or breast feeding. * evidence of significant concomitant disease * primary or secondary immunodeficiency * active infection of any kind * history of previously untreated infection with mycobacterium tuberculosis or current treatment for same. * history of cancer * any history or presence of congestive heart failure (chf) (new york heart association classification for chf: class iii or iv). * any history of myocardial infarction within 5 years. * history of a severe allergic or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of adalimumab or methotrexate. * positive serology for hepatitis b or c indicating active infection. * hemoglobin \< 8.0 g/dl. * absolute neutrophil count (anc) \< 1.5 x 103/l. * liver function abnormality

Keywords: rheumatoid arthritis clinical remission
safety and feasibility of arrhythmia ablation using the amigo remote robotic system as compared with manual ablation

Conditions: Arrhythmias

Summary: the aim of this prospective observational study is to evaluate the performance of amigo rcs in ablation procedures for most common arrhythmias as compared to a conventional manual approach.


Eligibility criteria:
inclusion criteria: * patients referred to our electrophysiology laboratory to treat any type of arrhythmia with catheter ablation exclusion criteria: * na
treatment of older adult acute myeloid leukemia patients aged 55 to 65 years

Conditions: Acute Myeloid Leukemia

Summary: the purpose of this study is to determine whether the escalation dosage of daunorubicin and cytarabine is effective and safety in the treatment of older adult chinese acute myeloid leukemia（aml） patients aged 55 to 65 years.

the da 3+7 regimen is the standard therapy in the aml treatment.escalated dosage of daunorubicin in induction therapy is reported effective and result in a more rapid response and a higher response rate than does the conventional dose, without additional toxic effects in elderly aml patients between 60 to 65 years.higher overall survival rate and event-free survival rate was obtained in escalated group compared with conventional dose. we are wondering if chinese older aml patients can benefit from this escalated induction regimen. high dose cytarabine in aml consolidation is reported improving the survival of elderly aml patients than the conventional dose，but it is not determined in chinese older adult aml patients.

Eligibility criteria:
inclusion criteria: * primary aml（except apl patients）; * ecog ps:0-2 exclusion criteria: * aml patient who has already received induction treatment, no matter what the outcome is; * treatment-related aml; * active cancer patients who's condition need to be treated; * the one with serious infectious diseases（eg.uncontrolled tuberculosis or invasive pulmonary aspergillosis） * active heart disease.
effect of ciclesonide on exercise induced bronchoconstriction

Conditions: Asthma

Summary: the purpose of this study is to study the effects of once daily inhaled ciclesonide at varying doses on exercise provoked asthma symptoms, fall in lung function after exercise and sputum characteristics.

to study the effects of 4 doses of ciclesonide on exercise-induced bronchoconstriction, bronchial responsiveness to mannitol, sputum parameters and other parameters of asthma control in asthmatic patients. the primary aim was to evaluate exercise-induced bronchoconstriction as a method of determining the dose and time responses of inhaled corticosteroid therapy. the secondary aims were to evaluate the dose and time responses of sputum parameters and responsiveness to mannitol to inhaled corticosteroid therapy. furthermore to explore the relationship(s) between exercise induced bronchoconstriction, sputum parameters and mannitol responsiveness.

Eligibility criteria:
inclusion criteria: * stable asthma not on maintenance asthma medications * exercise induced bronchoconstriction on dry air exercise challenge. exclusion criteria: * other significant co-morbidity or treatments that might interfere with the conduct or results of the study * fail to return to baseline after a maximum washout period of 8 weeks * unable to perform the procedures of the study

Keywords: asthma exercise induced bronchoconstriction sputum eosinophils
pediatric intubation

Conditions: Intubation; Cardiac Arrest

Summary: the aim of the study was to compare time and success rates of truview pcd video laryngoscope and macintosh laryngoscope for the pediatric emergency intubation with three airway scenarios in a standardized manikin model.


Eligibility criteria:
inclusion criteria: * give voluntary consent to participate in the study * inexperienced in pediatric intubation paramedics exclusion criteria: * not meet the above criteria * participants who had performed intubation in pediatric humans prior the trial or had previously truview experience
safety and efficacy of zicronapine in patients with schizophrenia

Conditions: Schizophrenia

Summary: to assess the effect of zicronapine versus risperidone on metabolic parameters comprising body weight, body mass index (bmi), waist circumference, levels of fasting blood lipids and glucose during 6 months of treatment.

schizophrenia is a serious and disabling mental disorder that affects approximately 1% of the world's population. antipsychotic drugs remain the cornerstone in the pharmacotherapy of schizophrenia. there are a number of antipsychotic drugs in use but none is ideal, in particular because their safety profile is complex and their effectiveness is limited. thus, present treatment options leave room for improvement and call for new, more effective pharmacotherapies for the treatment of schizophrenia. in the current study, non-acute patients with schizophrenia will be randomised to blinded treatment with either zicronapine or a standard antipsychotic treatment for 24 weeks. the safety (with focus on metabolic parameters) and efficacy of zicronapine will be evaluated in comparison to risperidone.

Eligibility criteria:
inclusion criteria: * the patient meets the diagnostic and statistical manual of mental disorders, 4th edition, text revision (dsm-iv-tr) criteria for schizophrenia * the patient is a man or woman, ≥18 and ≤65 years old * the patient has a panss total score ≥60 and ≤100 (extremes included) at screening and baseline exclusion criteria: * the patient has a current, predominant axis i psychiatric disorder other than schizophrenia as defined in the dsm-iv-tr * the patient has a current diagnosis or a history of substance dependence (except nicotine) or substance abuse (except cannabis) according to the dsm-iv-tr criteria ≤6 months prior to screening * the patient is at significant risk of harming him/herself or others according to the investigator's judgement (assisted by the assessment of suicidal ideation and behaviour using the c-ssrs) * the patient is resistant to antipsychotic treatment according to the investigator's judgement or has been treated with clozapine ≤3 months prior to screening * the patient has experienced an acute exacerbation requiring hospitalisation ≤3 months prior to screening or between screening and baseline * the patient has been treated with risperidone or paliperidone ≤6 months prior to screening other inclusion and exclusion criteria may apply.

Keywords: schizophrenia antipsychotic risperidone lu 31-130
effects of exercise on the symptoms of premenstrual syndrome and dysmenorrhoea and blood flow of genital tract

Conditions: Premenstrual Syndrome; Dysmenorrhoea

Summary: effects of exercise on the symptoms of premenstrual syndrome and dysmenorrhoea and blood flow of genital tract. different self-reported questionnaires and vaginal ultrasound flowmetry are used in the prospective observational trial. the study has interventional and control groups. there are changes in premenstrual syndrome complaints and dysmenorrhoea complaints during the study period.the deegre of menstrual pain and self-awareness improve during the period of study. the ultrasound examination shows changes in genital blood flow after exercise.

subject of the study: examination of premenstrual syndrome and dysmenorrhoea treatment results with aviva exercise intervention. method of the study: prospective observational trial with the participation of volunteers. questionnaires: 1. prism calendar: prospective record of the impact and severity of menstrual symptoms (reid, 1995). the participants have to fill out this every day, 2. the body awareness questionnaire shields, s. a., mallory, m.e., \& simon, a. (1989). the body awareness questionnaire: reliability and validity. journal of personality assessment, 53(4), 802-815 3. examination to measure the intensity of menstrual pain: numeric rating scale 4. heart rate monitoring and documentation before and after the exercises; completion of the borg scale of perceived exertion to measure exercise intensity; 5. questionnaire of life style 6. beck depression questionnaire ultrasound examination: doing the aviva exercises, ultrasound measurements are performed in robert hospital (budapest) on the patients participating in the study. the first measurement is performed for each person before starting the exercises. when the first subject has finished the exercise, a control ultrasound measurement will be carried out. in the control group there is also twice ultrasound examination for the individuals. measured parameters: pi (pulsatility index) of uterine artery transvaginal ultrasound measurement followed by statistical evaluation of the results.

Eligibility criteria:
inclusion criteria: * bmi 17-35 * regular menstrual cycles (cycles of 21-35 days) * no endocrinological disease * no endometriosis * no experience in aviva aerob exercises * symptoms of premenstrual syndrome * symptoms of dysmenorrhoea * score below 40 from beck depression questionnaire exclusion criteria: * pregnancy * pelvic inflamatory disease (pid), secondary dysmenorrhoea * gynecological operation * failure to complete the questionnaire (3 consecutive days and 5 days interrupted) * dissatisfaction with the continuation of the research * the incidence of adverse life events in the last 3 months * use of medication (e.g. oral birth control pill,painkiller,antipsychotic tablets) * participation in other sports programs * congenital uterine anomalies * any chronic disease (e.g. neurological, psychological disorders, endocrinological diseases)
sentinel lymph node localisation with an ultra-low dose of magtrace in breast cancer patients

Conditions: Breast Cancer; Sentinel Lymph Node

Summary: the overall aim is to demonstrate that the use of superparamagnetic iron oxide nanoparticles (spio) as a tracer in an ultra-low dose (0.1 ml) is non-inferior for sentinel lymph node (sln) detection in patients with breast cancer compared to the dual technique using tc99m +/- blue dye, and to evaluate mri breast artefacts and skin staining over time.

the overall aim is to demonstrate that the use of superparamagnetic iron oxide nanoparticles (spio) as a tracer in an ultra-low dose (0.1 ml) is non-inferior for sentinel lymph node (sln) detection in patients with breast cancer compared to the dual technique using tc99m +/- blue dye, and to evaluate mri breast artefacts and skin staining over time. this is a prospective cohort study where all research persons have sln biopsy using both spio and the dual technique. then the investigators will compare sln detection rates between magtrace 0.1 ml and the dual routine technique with radioactive tracer (technetium99m, tc99) +/- blue dye.

Eligibility criteria:
inclusion criteria: * planned for sentinel lymph node biopsy at (or after) breast surgery * signed and dated written informed consent before the start of specific protocol procedures exclusion criteria: * pregnant or breast-feeding * iron overload disease * known hypersensitivity to iron, dextran compounds or blue dye. * inability to understand given information and give informed consent or undergo study procedures

Keywords: breast cancer sentinel lymph node biopsy
negative pressure dressing after saphenous vein harvest

Conditions: Coronary Artery Disease; Complication of Coronary Artery Bypass Graft; Wound Complication

Summary: this study will test the effectiveness of negative pressure wound therapy (using the vac prevena device, kci canada inc.) applied to the saphenous vein harvest site after coronary artery bypass grafting (cabg). when initiated immediately after surgery, this intervention may decrease the incidence of wound infection and non-infectious wound complications. it may decrease wound discomfort and improve mobility and functional recovery of the leg.


Eligibility criteria:
inclusion criteria: * patients presenting for elective or semi-elective isolated first-time cabg surgery with harvesting of the greater saphenous vein. * must be 18 years or older. * must live with one hour driving distance from calgary. * must provide written consent. exclusion criteria: * previous cabg surgery or previous lower leg surgical intervention. * in emergent need for surgery. * have severe peripheral vascular disease. * do not speak and read the english language. * have dialysis-dependent renal failure. * require chronic steroids. * unable to return to clinic for follow-up due to functional or cognitive impairment.

Keywords: cardiac surgery. wound healing. leg wound infection. wound care.
induction of ovulation using clomiphene citrate and n-acetyl cysteine versus letrozole

Conditions: Infertility

Summary: infertility is defined as a couple's inability to become pregnant after one year of unprotected intercourse in women 35 years old and younger, and for six months in women over age 35 years. in any given year, about 15 percent of couples in north america and europe who are trying to conceive are infertile


Eligibility criteria:
inclusion criteria: * all primary and secondary. infertility due to anovulation exclusion criteria: * male factor infertility, tubal factor. * endocrineopathy * hypothyrodism * morbid obesity * under weight * patient with previous surgery including drilling of ovary, clomiphene citrate resistant to ovulation.
intratumor cpg-odn injection boosters immune killing against in situ tumor antigen release for advanced solid tumors

Conditions: Lung Cancer; Hepatocellular Carcinoma; Solid Tumor

Summary: to study the safety and clinical effects of intratumor injecting cpg-odn and in situ release of tumor antigen by interventional ablation or drug-eluting beads to treat advanced solid tumors.

1. percutaneous microwave ablation or intratumor injection of drug-eluting beads to destroy cancer cells to release tumor-specific antigens 2. intratumor injection of type a/c cpg-odn with or without infusion of car-t cells secreting scfv against ox40 3. assessing side effects and therapeutic efficacy after the combined treatments

Eligibility criteria:
inclusion criteria: * solid advanced malignant tumors * age between18 and 80 years * life expectancy is greater than three months exclusion criteria: * benign tumor * life expectancy is less than three months * serious medical comorbidity * others
randomized controlled trial comparing transanal doppler-guided arterial ligation with mucopexy and stapled haemorrhoidopexy

Conditions: Symptomatic Haemorrhoidal Disease Requiring Surgical Management

Summary: this multicentre rct aims to compare two surgical treatments of haemorrhoidal disease: doppler-guided arterial ligation with mucopexy (dgalm) and stapled haemorrhoidopexy according to longo (sh). the hypothesis of the trial is that the dgalm is at a lesser risk and is more cost-effective than sh. with a large number of patients managed in more than 20 centres, we aim to demonstrate that dgalm has a lower morbidity than sh when treating haemorrhoidal disease. at a lower postoperative risk and a lower risk of sequelae, the dgalm would demonstrate to be cost-effective for health care system and attractive for patients.


Eligibility criteria:
inclusion criteria: * patient (male or female) 18 - 75 y.o * suffering from symptomatic grade ii or iii haemorrhoidal disease (bleeding and/or prolapse) * requiring surgery exclusion criteria: * acute complication of haemorrhoidal disease * history of anal surgery for haemorrhoids * congenital or acquirred anal stenosis * anal fissure or perianal abcess * inflammatory bowel disease * colon or rectal cancerv history of rectal or sigmoid resection * rectal prolapse * portal vein hypertension * haemophylia * pregnancy

Keywords: haemorrhoids, surgery, cost-effectiveness, morbidity, risk assessment,rct, stapled haemorrhoidopexy, doppler-guided, haemorrhoidal artery ligation, outcome