Kornimate/medical-research-clean huggingface dataset:
preoperative education

Conditions: Postoperative Pain

Summary: the investigators will evaluate the effect of preoperative education on postoperative opioid.

the investigators propose a randomized trial to be performed at the cleveland clinic. patients will be assigned to: 1) an educational video focused on postoperative analgesia modalities, opioids, and realistic pain expectations (analgesic education); or, 2) an educational video focused on other aspects of the perioperative experience.

Eligibility criteria:
inclusion criteria: * modified informed consent * adults ≥18 years * american society of anaesthesiologists physical status 1-4 * scheduled for hip arthroplasty, laparoscopy assisted colorectal surgery * personal visit the pace clinic * anticipated overnight postoperative hospitalization * reasonable english fluency exclusion criteria: * opioid use for more than 30 consecutive days within three preoperative months, at a daily dose of 15 mg or more of morphine or equivalent * regional block or epidural analgesia
effects of mat pilates versus functional training on mechanical low back pain

Conditions: Mechanical Low Back Pain

Summary: this study will be a randomized clinical trial. total 44 subjects with mechanical low back pain will be assigned randomly by using non probability convenient random sampling in to two groups with 22 subjects in each group. subjects in one group will be treated with mat pilates training and the other group with the functional training. nprs, inclinometer and urdu version of modified oswestry disablility questionair would be used to measure the outcome of pain, range of motion and disability respectively. after data collection from defined study setting, data will be entered and analyzed at riphah international university lahore.

mechanical low back pain refers to back pain that arises intrinsically from the spine, intervertebral disks, or surrounding soft tissues. this includes lumbosacral muscle strain, disk herniation, lumbar spondylosis, spondylolisthesis, spondylolysis, vertebral compression fractures, and acute or chronic traumatic injury. repetitive trauma and overuse are common causes of chronic mechanical low back pain, which is often secondary to workplace injury. pilates focus is improving the core strength, it trains the body as an integrated whole. functional training involves the daily life activities that also targets on core stability and strength. the aim of the study is to present the current state of knowledge concerning the application of pilates and functional training in terms of duration, frequency and specific exercises in the management of mechanical low back pain in terms of pain, rom and disability improvement. effects of mat pilates and functional training on mechanical low back pain are checked individually before but their effects are not compared previously.

Eligibility criteria:
inclusion criteria: * both male and female * age group 25-40 * patient having mechanical low back pain for more than 12 weeks exclusion criteria: * pregnancy * previous spinal surgery * orthopedic and neurological diseases * patients with serious spinal pathologies( tumor, fracture and autoimmune conditions)

Keywords: disability pilates training range of motion pain
interferon alfa in treating patients with newly diagnosed chronic myelogenous leukemia

Conditions: Leukemia

Summary: rationale: interferon alfa may interfere with the growth of cancer cells. low doses of interferon alfa may be as effective as high doses. purpose: randomized phase iii trial to compare the effectiveness of low-dose or high-dose interferon alfa in treating patients who have newly diagnosed chronic myelogenous leukemia.

objectives: i. compare the duration of chronic phase and survival following low- vs. high-dose interferon alfa maintenance therapy in patients with chronic myelogenous leukemia in chronic phase. ii. compare the toxicity profiles, assessed by who criteria, and the percentage of patients requiring dose reduction or discontinuation with these two regimens. iii. compare hematologic and cytogenetic responses every 6 months in patients treated on these two regimens. outline: this is a randomized study. patients receive daily hydroxyurea until their white blood cell count (wbc) is maintained at a normal level for 2-3 weeks. patients are randomized to two groups: one group receives daily high-dose interferon alfa, and the other receives low-dose interferon alfa, 5 days per week. both groups continue to receive hydroxyurea at reduced doses as needed to maintain a normal wbc. treatment continues until disease progression occurs. patients may receive cytarabine in addition to interferon in either treatment arm at the investigator's discretion. cytarabine is given subcutaneously for 10 days every calendar month and continues in the absence of disease progression or unacceptable toxicity. patients are followed every 6 months for survival. projected accrual: approximately 800 patients will be enrolled over 8 years on this multicenter study.

Eligibility criteria:
disease characteristics: chronic myelogenous leukemia in chronic phase molecular evidence of bcr/abl rearrangement or presence of philadelphia chromosome eligibility for allogeneic bone marrow transplantation does not exclude patient characteristics: age: adult performance status: who 0-2 hematopoietic: not specified hepatic: bilirubin less than twice normal no severe hepatic problem renal: creatinine less than twice normal no severe renal problem cardiovascular: no severe cardiovascular problem other: no contraindication to interferon therapy no history of severe depression no pregnant women effective contraception required of fertile women prior concurrent therapy: no prior therapy prior therapeutic or back-up leukapheresis allowed hydroxyurea may be started up to 4 weeks prior to entry

Keywords: chronic phase chronic myelogenous leukemia chronic myelogenous leukemia, bcr-abl1 positive philadelphia chromosome negative chronic myelogenous leukemia
randomized controlled trial comparing mbsr to set in breast cancer patients

Conditions: Breast Neoplasms

Summary: this study will compare three standard treatment programs commonly offered to patients with breast cancer. the three programs being compared are 1) mindfulness meditation-based stress reduction (mbsr), 2)supportive- expressive group therapy (set), and 3) a one day stress-management seminar. the purpose of this study is to determine if these three treatments have different effects on psychological well-being, the immune system, and the amount of stress hormones in the bloodstream.


Eligibility criteria:
inclusion criteria: * study participants must be women diagnosed with stage i, ii, or iii breast cancer within the previous 18 months, have completed all treatments with the exception of hormonal therapy at least three months previously, over the age of 18, and have a score of 13 or higher on the bsi-18. previous meditation/yoga experience is allowed but will be recorded. exclusion criteria: * participants must not have a concurrent dsm-iv diagnosis of psychosis, substance abuse, bipolar disorder, or active suicidality (as assessed by structured clinical interview), must not be currently using psychotropic medications (antipsychotics, antidepressants, anxiolytics), have a concurrent autoimmune disorder, or have participated previously in mbsr or set group.

Keywords: breast neoplasms stress personality psychology
study of the prevalence of endometriosis and adenomyosis

Conditions: Elective Fertility Preservation

Summary: our study aims to assess the prevalence of adenomyosis and endometriosis in patients consulting for elective fertility preservation through the diagnosis of these pathologies by transvaginal pelvic ultrasound. imaging data will be compared with clinical data (patient characteristics, clinical symptoms) as well as the assessment of anxiety, depression, and quality of life collected from the women.

adenomyosis and endometriosis are two heterogeneous benign gynecological pathologies, in terms of the presence of diverse phenotypes and their symptomatic presentation: while some women are entirely asymptomatic, others experience pelvic pain, infertility, or abnormal uterine bleeding. assessing the prevalence of these two pathologies is challenging: on the one hand, a significant number of women are asymptomatic and not considered in the calculation; on the other hand, endometriosis and adenomyosis are often underdiagnosed, leading to delayed diagnosis. endometriosis and adenomyosis are frequently associated. improving knowledge about the epidemiology of endometriosis and adenomyosis is crucial as both are major causes of clinical symptoms that adversely affect the quality of life in numerous women. this is a significant issue for women's health due to the associated suffering, numerous surgical interventions, healthcare expenses, and the suggested link with pathologies that may affect other organs. understanding the disease could lead to improved treatment and the development of preventive strategies. therefore, it is urgent to determine the frequency of endometriosis and adenomyosis, as well as the correlation between women's characteristics, especially their clinical symptoms, and different phenotypes. in order to assess the prevalence of adenomyosis and endometriosis in a population of women of reproductive age, the investigators intend to conduct this single-center study focusing on patients consulting for non-medical fertility preservation.

Eligibility criteria:
inclusion criteria: * woman aged between 29 and 37 * consultant for non-medical fertility preservation in the reproductive medicine unit port royal, cochin * informed and not opposed to this research * affiliated to a social security scheme exclusion criteria: * pregnant women * refusing to take part in the study * under court protection, curatorship or guardianship * women with a known malformation of the genital tract

Keywords: endometriosis adenomyosis prevalence elective fertility preservation transvaginal pelvic ultrasound
bronchoscopy screening for high-risk population of lung cancer with severe smoking with negative ldct screen

Conditions: Heavy Smoking

Summary: based on the previous work of ldct screening, in order to improve the screening rate of central lung cancer for ldct negative and severe smokers, the investigators plan to conduct china's first large-scale fluorescent bronchoscopy screening test.

ct scan is a commonly used method for clinical screening for early lung cancer, but research shows that ldct scan has a higher detection rate for peripheral lesions (often adenocarcinoma), and a lower detection rate for central lung cancer (mostly squamous cell carcinoma). fluorescent bronchoscopy uses the principle of differentiating fluorescence in different tissues to distinguish normal parts from diseased parts. it is often used for screening of central early lung cancer.based on the results of the investigator's previous research, the investigators plan to conduct a second round of community screening-bronchoscopy screening, and perform white light bronchoscopy and autofluorescence bronchoscopy screening for high-risk groups of lung cancer with heavy smoking (≥400 years) and no obvious lung nodules.

Eligibility criteria:
inclusion criteria: 1. age 45-75 years; 2. have a smoking history of ≥20 pack years; if participants quit smoking, it should be \<15 years; 3. chest ldct examination within one and a half years without obvious abnormalities or calcified nodules or non-calcified nodules and no signs of malignancy exclusion criteria: 1. non-smokers or mild smokers; 2. there are contraindications to bronchoscopy, such as active hemoptysis, unstable angina pectoris, coagulation dysfunction, anesthesia allergy, etc .; 3. refusing to sign informed consent; 4. the operator believes that the patient has other conditions that are not suitable for bronchoscopy.

Keywords: heavy smoking people at high risk for lung cancer autofluorescence bronchoscopy，afb white light bronchoscopy, wlb
pilot study of nasha/dx gel for fecal incontinence

Conditions: Fecal Incontinence

Summary: the study is an open, prospective, single-site study where 16 patients suffering from fecal incontinence will be included. change in fecal incontinence episodes after intersphincteric injection of nasha/dx gel 4x2 ml and retreatment 4x2 ml after 4 weeks will be measured.


Eligibility criteria:
inclusion criteria: 1. fecal incontinence with at least 2 episodes/week 2. symptom duration at least one year 3. failed attempt of conservative therapy 4. age 18-80 5. written informed consent 6. available for follow-up 7. fully compliant with protocol exclusion criteria: 1. active inflammatory bowel disease 2. total external sphincter defect at ultrasound and clinical examination 3. bleeding diathesis or anticoagulant therapy 4. rectal prolapse or intussusceptions 5. present anal sepsis 6. anorectal implants 7. recent anorectal surgery (within 6 months) 8. rectal anastomosis 9. pregnancy, postpartum (one year) or breast feeding
efficacy of probiotics on excessive gas accumulation

Conditions: Flatulence; Bloating

Summary: efficacy of probiotics on excessive gas accumulation


Eligibility criteria:
inclusion criteria: * healthy adults 18-50 years, at the time of signing the informed consent. * willing and able to give written informed consent for participating in the study * willing to comply with all study procedures exclusion criteria: * chronic intestinal disease, immunodeficiency disorder or immunosuppressive treatment * clinically significant frequent constipation or diarrhea at the screening visit as judged by the investigator * known gluten intolerance, lactose intolerance, milk protein allergy * vegetarian diet * intake of antibiotics within four weeks prior to the start of the study * hypersensitivity to any of the ingredients in the investigational product (ip) * regular intake of probiotics within four weeks prior to the start of the study * history of any clinically significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk if participating in the study, or influence the results or the subject´s ability to participate in the study * investigator considers the subject unlikely to comply with study procedures, restrictions and requirements.
quality of life in patients with intermediate uveitis

Conditions: Macular Edema

Summary: the aim of this study is to determine if macular edema is associated with less visual function and quality of live in patients with intermediate uveitis


Eligibility criteria:
inclusion criteria: * pars planitis exclusion criteria: * patients with any other diseases * patients under age 18

Keywords: quality of life in patients with macular edema compared to patients without macular edema.
family-centered support program for caregivers of stroke survivors

Conditions: Stroke; Caregiver Burden

Summary: the goal of this study is to evaluate the effect of a family-centered support program on the care burden, depressive symptoms, perceived social support, and quality of life of stroke survivor' caregivers and on care recipients' rehabilitation adherence and depressive symptoms.

the family-centered support program included stroke and rehabilitation education, problem-solving skills training, long-term care information support, and instant messaging applications-based 24-h peers-support group for caregivers. investigators hypothesized that (1) compared with those in the control group, caregivers who undergo a family-centered support program have lower care burdens, do not have a high risk of depression, and perceive better social support and quality of life; (2) compared with those in the control group, care recipients in the family-centered support group have ideal rehabilitation adherence and are not at a high risk of depression.

Eligibility criteria:
inclusion criteria: 1. caregivers: * aged 20 years or older * primarily responsible for caring for the stroke survivor in the hospital and after discharge. 2. stroke survivors: * diagnosed with moderate stroke (national institute of health stroke scale ≥5 or modified rank in scale ≥3), including ischemic and hemorrhagic stroke, via computed tomography or magnetic resonance imaging within one month. admitted to the stroke unit at a medical center * had a primary family caregiver. exclusion criteria: 1. caregivers: * refusal to participate in the study * unable to communicate, for example, non-chinese speakers * reported having been diagnosed with psychiatric illness (such as major depression) and undergoing treatment. 2. stroke survivors: * unstable vital signs * terminal illness * transfer to long-term care facilities after hospital discharge * self-reported having been diagnosed with psychiatric illness (such as major depression) and undergoing treatment.

Keywords: family-centered intervention
neuromodulation of aspiration secondary to stroke

Conditions: Deglutition Disorders

Summary: aspiration could induce major respiratory affection. they are often present after stroke. the aim of this study is to facilitate swallowing recuperation in stroke patients using peripheral laryngeal stimulation and to understand its mechanisms using motor evoked potential and cortical evoked potential.


Eligibility criteria:
inclusion criteria: stroke aspiration exclusion criteria: pace maker tracheostomy epilepsy pregnancy

Keywords: aspiration stroke motor evoked potential cortical evoked potential neuromodulation
optimizing treatment of stage iv breast cancer through real-time disease monitoring

Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Prognostic Stage IV Breast Cancer AJCC v8

Summary: this study evaluates if blood tests can detect changes in disease status during treatment for stage iv breast cancer. information from this study may help researchers learn more about metastatic breast cancer and how to optimize treatment.

primary objectives: i. to identify subtype-specific signatures for breast cancer using genomic positioning of plasma deoxyribonucleic acid (dna) fragments. ii. to validate changes in circulating tumor-derived dna (ctdna) levels as a biomarker for treatment monitoring in patients with metastatic breast cancer. outline: patients undergo collection of blood samples at baseline, 2 weeks after the start of treatment, and at the beginning of each new treatment cycle.

Eligibility criteria:
inclusion criteria: * adults \> 18 years of age * stage iv breast cancer undergoing cancer treatment exclusion criteria: * stage i-iii breast cancer * unwilling or unable to give consent * patients with a prior or concurrent malignancy, excluding non-melanoma skin cancers and non-invasive cancers whose natural history or treatment does not have the potential to interfere with the assessment of the investigational marker
inhaled nitric oxide in brain injury

Conditions: Traumatic Brain Injury

Summary: this study will evaluate the changes in respiratory mechanics following traumatic brain injury and determine the effect of inhaled nitric oxide on gas exchange.

intubation and mechanical ventilation are common treatments in the care of patients with traumatic brain injury (tbi). intubation allows for airway control and facilitates removal of respiratory secretions. mechanical ventilation allows control of arterial carbon dioxide to aid in control of intracranial pressure. recent evidence suggests that lung protective ventilation (tidal volumes of 6 ml/kg of predicted body weight and moderate positive end expiratory pressure) improves outcomes following brain injury and reduces brain-lung cross talk. the treatment of respiratory failure in tbi must balance the need to improve lung function with the negative consequences of increased intrathoracic pressure on mean arterial pressure, intracranial pressure and venous return. traditional treatment of increasing positive end expiratory (peep) and mean airway pressure then, represent competing interests. methods for improving arterial oxygenation while avoiding negative hemodynamic effects are needed. the impact of head injury on respiratory mechanics has been studied in just a few clinical investigations. (1-3) of note, the earliest of these noted that the ventilation perfusion (v/q) matching following tbi was not the result of lung collapse or parenchymal lung disease but secondary to alterations in perfusion. there are three possibilities for this finding: 1. redistribution in regional perfusion, which is partially mediated by the hypothalamus 2. pulmonary microembolism, leading to increased dead space 3. lung surfactant depletion due to excessive sympathetic stimulation and hyperventilation. the introduction of inhaled pulmonary vasodilators such as inhaled nitric oxide or aerosolized epoprostenol offer an opportunity to improve oxygenation in patients with tbi without increasing airway pressures in the face of v/q inequalities. this study will evaluate the changes in respiratory mechanics following tbi and determine the effect of inhaled nitric oxide on gas exchange.

Eligibility criteria:
inclusion criteria: * hospital admission with traumatic brain injury (penetrating or blunt) * requirement for mechanical ventilation * glasgow coma score \> 3 exclusion criteria: * brain death * expected survival \< 48 hours * air leak (bronchopleural fistula, tracheal injury) * current inspired oxygen concentration (fio2) \> 0.65 * hemodynamic instability (systolic blood pressure \< 100 mm hg, cardiac arrhythmia) * uncontrolled intracranial pressure (\> 20 mm hg) * spinal cord injury with hypotension * severe acute respiratory distress syndrome (ards) (pao2/fio2 \< 100) * chest abbreviated injury score (ais) \> 3 * first rib fracture * flail chest

Keywords: mechanical ventilation inhaled nitric oxide
prospective study of cerebrovascular accidents (cva) in 3 french cities (besançon, cayenne and tours)

Conditions: Cerebrovascular Accident; Thrombolysis

Summary: the objective of this study is to specify the typology of cva in french guiana by prospectively comparing consecutive strokes observed at each of the three study sites (cayenne, tours, besançon)

cva is a public health problem that is managed in a codified manner by the neurovascular units (nu). in cayenne, in the absence of a nu, strokes are managed directly in the emergency room by 24-hour telemedicine provided by the neurovascular team at the besançon university hospital. the vascular neurologist can perform a clinical examination remotely in a dedicated examination room and has access to magnetic resonance imaging by image transfer. the tours and besançon university hospitals each have a regional reference nu. the coordinating investigator of the study is the head of the neurology department of the tours university hospital, currently on an extended mission in cayenne. the initial emergency management of a person with stroke who is hospitalized is comparable between the three regions studied. epidemiological studies show disparities in stroke mortality and vascular risk factors between french regions. the stroke mortality rate in french guiana in 2013 (72 per 100 000 population per year) was twice that of metropolitan france. the standardized prevalence rate of diabetes in french guiana is 7.1% of the population compared with 4.4% in metropolitan france, and the prevalence of hypertension is twice as high among women in the french guiana west indies compared with metropolitan france. there are twice as many obese persons (bmi\>30) in guyanese women compared with metropolitan france. we propose a prospective observational study based on the following hypothesis: the average age of stroke occurrence, its type (ischemic or hemorrhagic), the vascular territories involved, the vascular risk factors, and the pre-hospital and intra-hospital management times will be superimposable between two metropolitan regions but different in french guyana.

Eligibility criteria:
inclusion criteria: * patient with a diagnosis of cerebral vascular accident confirmed on mri exclusion criteria: * age under 18 years * absence of mri