Kornimate/medical-research-clean huggingface dataset:
muscle impact of treating osteoporosis

Conditions: Sarcopenia; Osteoporosis

Summary: osteosarcopenia is a geriatric musculoskeletal syndrome characterized by co-existence of osteoporosis and sarcopenia (low skeletal muscle mass, strength, and/or functional capacity). there is strong evidence of overlap between the pathophysiology of osteoporosis and sarcopenia (muscle-bone crosstalk). this research plan will further explore the relationship between bone and muscle, and provide new information about effect of osteoporosis medications on muscle health in older adults who are under treatment for osteoporosis.


Eligibility criteria:
inclusion criteria: ambulatory adults age ≥65 years including those using assistive devices to maximize generalizability, if they have criteria for treating osteoporosis including: 1. osteoporosis by axial bone density (spine, hip or forearm bmd t-score ≤-2.5 sd) or 2. a previous adult fragility fracture of the spine or hip or 3. would be treated based on frax national osteoporosis foundation treatment thresholds of a 10-year risk of ≥ 20% for a major osteoporotic fracture or ≥ 3% for hip fracture using femoral neck bmd. exclusion criteria: 1. patients with a calculated creatinine clearance \< 35 ml/min or 2. who have a contraindication for bisphosphonates or denosumab or 3. those who are scheduled for a tooth extraction to avoid jaw osteonecrosis or 4. subjects with severe liver disease or 5. those who have been on oral bisphosphonates for the past 1 year and intravenous bisphosphonates for the past 2 years prior to the study or 6. men
exercise in prematurely born preadolescents to mitigate cardiovascular risk and improve cognitive impairment

Conditions: Preterm Birth

Summary: excelsior is a randomized controlled trial to investigate the effect of physical exercise on cardiovascular health in prematurely born children. participants will be randomly allocated to either an intervention group or a control group. the intervention will receive a child-friendly physical exercise program and the control group will receive age appropriate lifestyle- and exercise recommendations.

premature birth, i.e. the birth of babies before the 37th week of pregnancy, is an increasing challenge. since the 1980s, medical advances such as special medication and ventilation techniques have significantly improved the chances of survival for premature babies. worldwide, around 11% of all births are premature. prematurity increases the risk of cardiovascular disease. studies show that very premature babies have a significantly higher risk of heart problems. however, only little is known whether physical exercise could improve cardiovascular and cognitive function in prematurely born children. all participants will undergo a baseline visit to assess vascular, cognitive and cardiopulmonary function. at the end of the visit, participants will be randomly allocated to either an intervention group or a control group. the intervention will receive a child-friendly physical exercise program and the control group will receive age appropriate lifestyle- and exercise recommendations. the physical exercise program is held 2-3 times per week for ten weeks targeting cardiovascular health and coordination. after 10 weeks, all participants will undergo a follow-up visit at which all measures will be repeated.

Eligibility criteria:
inclusion criteria: * boys and girls born prematurely (\<= 32th week of gestation) * aged 6 to 12 years * informed consent provided exclusion criteria: * attendance of special education services related to attention disorders * colour blindness or any chronic eye disorder * being under pharmacological treatment for any mental disorder * injuries, significant motor- or other disabilities which prohibit the participation in physical exercise * visually provoked epilepsy * children for whom no informed consent is provided
pilot project on the automatic design and 3d printing of adolescent idiopathic scoliosis braces (phase 1)

Conditions: Adolescent Idiopathic Scoliosis

Summary: the goal of this pilot clinical trial is to validate a 3d printed brace designed automatically for patients with adolescent idiopathic scoliosis. the main question it aims to answer is: which parameters leads to a efficient and comfortable brace. participants will try the brace for a period of 30 minutes, measurement and feedback will be obtained.


Eligibility criteria:
inclusion criteria: * diagnostic of adolescent idiopathic scoliosis * risser 0-2 * cobb angle between 20 and 40 degrees * prescription for a brace * able to understand french or english exclusion criteria: * grade ii or higher spondylolisthesis * neuromuscular disease * past spinal surgery

Keywords: scoliosis 3d printing finite element analysis
efficacy and safety of imported probucol to treat hyperlipidemia

Conditions: Hyperlipidemia

Summary: the purpose of this study is to evaluate the efficacy and safety of imported probucol in hyperlipidemia patients.

this is a randomized, double blind, placebo control, multi-centre clinical study in hyperlipidemia patients. enrolled subjects will be randomized to the treatment group or control group, and receive probucol or placebo continuously for 8 weeks; treatment group: imported probucol 250 mg (1 tablet) bid. p.o control group: placebo 1 tablet bid. p.o

Eligibility criteria:
inclusion criteria: 1. signing informed content form; 2. age \>= 20 (the age at the time of signing icf; both gender); 3. hyperlipidemia patients who meet the following criteria: * 4.14 mmol/l (160mg/dl) =\< ldl-c (serum low density lipoprotein-cholesterol) \< 6 mmol/l (232mg/dl) * tg (serum triglycerides) \< 4.5 mmol/l (398mg/dl); 4. framingham: coronary heart disease 2-year risk probabilities \< 10%. exclusion criteria: 1. subjects who receive antilipemic agents within 1 month prior to the pre-screening period; 2. subjects who receive probucol within 6 months prior to the pre-screening period; 3. coronary heart disease subjects; 4. subjects being treated with cyclosporine; 5. subjects with a history of hypersensitivity to probucol; 6. qtc interval \> 450ms (male); qtc interval \> 470ms (female); 7. subjects with impaired hepatic and renal function, who meet any of the following abnormal value: * ast \>= 100iu/l * alt \>= 100iu/l * serum creatinine \>= 1.5mg/dl 8. female subjects who are pregnant, lactating, or who plan to conceive; 9. subjects who are considered by the investigator to be inappropriate to participate in this trial.

Keywords: hyperlipidemia
the effects of a music intervention on stress, anxiety and academic performance on nursing students

Conditions: Stress

Summary: this study is examining the effect of listening to music on personal variables such as stress, anxiety, and academic performance. previous research has shown that listening to music can help in reducing the effects of anxiety and stress.

students will be divided and randomized into two recording groups: 1.) music intervention group, 2.) non-music control group. the music intervention group will receive a 15-minute music intervention and variables such as heart rate, blood pressure, anxiety, and academic performance will be measured. the non-music control group will not receive the intervention; however, the same variables will be measured.

Eligibility criteria:
inclusion criteria: * 18 years and older * enrolled at ut health san antonio school of nursing clinical course * first semester undergraduate nursing student exclusion criteria: * under 18 years * second, third or fourth semester undergraduate nursing student

Keywords: music, anxiety
follicular flushing in patients with suboptimal responses

Conditions: Infertility

Summary: the aim of the present study is to determine the effect of follicular flushing on the ongoing pregnancy rate in patients who developed four or fewer follicles of 14mm following standard ovarian stimulation for ivf.

oocyte aspiration under the guidance of transvaginal ultrasound is an integral part in ivf treatment. follicular flushing has been advocated. however, subsequent data from randomized trials failed to demonstrate any benefits with routine follicular flushing in normally responding patients. instead, it has been shown to prolong the operating time, increase the procedure-related pain and analgesics requirement. most of the ivf centers no longer perform routine follicular flushing in normally responding patients. the potential role of follicular flushing in patients with a limited number of developing follicles is conflicting based on the recently published randomized trials. the aim of the present study is to determine the effect of follicular flushing on the ongoing pregnancy rate in patients who developed four or fewer follicles of 14mm following standard ovarian stimulation for ivf.

Eligibility criteria:
inclusion criteria: 1. age of women \<43 years 2. normal uterine cavity on saline sonogram 3. endometrial thickness \>=8mm on the day of hcg exclusion criteria: 1. planned not to have fresh embryo transfer 2. cycle cancelled prior to hcg administration 3. natural cycle ivf 4. presence of hydrosalpinges on scanning which are not surgically treated 5. presence of endometrial polyps on scanning 6. undergoing preimplantation genetic diagnosis
remimazolam and remifentanil without neuromuscular blocking agent

Conditions: Myoma;Uterus; Polyp Endometrium; Unspecified Condition Associated With Female Genital Organs and Menstrual Cycle

Summary: remimazolam is a novel drug approved for induction and maintenance of general anesthesia. this study aims to check the appropriate dose and patient response by administering remimazolam and remifentanil in surgery that does not require a neuromuscular blocking agents.


Eligibility criteria:
inclusion criteria: * adult woman scheduled for gynecological surgery under general anesthesia * american society of anesthesiology grade 1 or 2 * when using a laryngeal mask airway to maintain general anesthesia exclusion criteria: * underlying diseases: liver, kidney, brain nervous system, glaucoma * patients with bmi greater than 30 and less than 18.5 * patients diagnosed with sleep apnea * alcohol or drug dependent patients * patients with severe or acute respiratory failure * lactose intolerance * dextran 40 hypersensitivity * patients in shock or coma
effects of neuromuscular electrical stimulation (nmes) in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to determine the effects of neuromuscular electrical stimulation (nmes) on neuromuscular and functional parameters in elderly with knee osteoarthritis. the hypothesis is that names is able to strengthen the quadriceps muscle and to improve healthy status of elderly with knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * women, minimum age of 50 years; * clinically diagnosed with knee oa; * no contraindications to execute maximal knee extension tests (e.g., cardiorespiratory complications); * no previous musculoskeletal or joint injuries besides knee oa; * no hip or knee surgery; * no neurological problems.

Keywords: elderly
investigating the influence of oral semaglutide on pharmacokinetics of metformin and digoxin in healthy subjects

Conditions: Diabetes; Healthy

Summary: this trial is conducted in europe. the aim of this trial is to investigate the influence of oral semaglutide on pharmacokinetics (the exposure of the trial drug in the body) of metformin and digoxin in healthy subjects.


Eligibility criteria:
inclusion criteria: * male or female, age 18-75 years (both inclusive) at the time of signing inform consent * body mass index (bmi) 20.0-29.9 kg/m\^2 (both inclusive) * a good general health based on medical history, physical examination, and results of vital signs, electrocardiogram and laboratory safety tests performed during the screening visit, as judged by the investigator exclusion criteria: * female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using adequate contraceptive methods. female of child bearing potential must use effective methods of birth control for the duration of the trial and for 5 weeks following last dose. only highly effective methods of birth control are accepted (i.e., one that results in a less than 1% per year failure rate when used consistently and correctly, such as implants, injectables, combined oral contraceptives, and some intrauterine devices) * history of crohn's disease, ulcerative colitis, or other inflammatory bowel disease * hypertension (defined as sitting systolic blood pressure above 140 mmhg and/or diastolic blood pressure above 90 mmhg). if white-coat hypertension is suspected at the screening visit a repeated measurement is allowed * any blood draw in excess of 25 ml in the past month, or donation of blood or plasma in excess of 400 ml within the 3 months preceding screening
safety and efficacy of g17dt immunogen in the treatment of gastric and gastroesophageal cancer

Conditions: Stomach Neoplasms; Esophageal Neoplasms

Summary: this study will test whether the g17dt immunogen, when administered in combination with chemotherapy, is an effective and safe treatment for gastric cancer.


Eligibility criteria:
inclusion criteria: * clinical diagnosis with gastric or gastroesophageal cancer * karnofsky performance status score of at least 70 * life expectancy of at least 3 months exclusion criteria: * prior treatment with chemotherapy or anticancer immunotherapy * bone marrow transplant within past year * chronic use of corticosteroids, except for inhaled corticosteroids used for asthma or chronic obstructive pulmonary disease * central nervous system metastases * immunodeficiency * hypercalcemia

Keywords: gastroesophageal cancer gastric cancer
camrelizumab plus decitabine in anti-pd-1 treatment-naive patients with relapsed/refractory classical hodgkin lymphoma

Conditions: Hodgkin Lymphoma

Summary: this is an open-label, phase 2/3，multicenter and single-arm clinical trial of camrelizumab plus decitabine for anti-pd-1 treatment-naive patients with relapsed or refractory hodgkin lymphoma. the primary objective of this study is to evaluate the long-term response duration with camrelizumab plus decitabine in relapsed or refractory hodgkin lymphoma.


Eligibility criteria:
inclusion criteria: * 1 subjects must have histological confirmation of relapsed or refractory hodgkin lymphoma (hl). * 2 12 to 75 years of age. * 3 ecog performance of less than 2. * 4 life expectancy of at least 3 months. * 5 subjects with lymphoma must have at least one measureable lesion \>1 cm as defined by lymphoma response criteria. * 6 subjects must have received at least two lines of prior regimens without anti-pd-1 antibody treatment history, and must be off therapy for at least 4 weeks prior to day 1. subjects with autologous hematopoietic stem-cell transplantation are eligible which must be more than 3 months. * 7 subjects must have adequate marrow, live, renal and heart functions. exclusion criteria: * 1 subjects with any autoimmune disease or history of syndrome that requires corticosteroids or immunosuppressive medications. * 2 serious uncontrolled medical disorders or active infections, pulmonary infection especially. * 3 active alimentary tract hemorrhage or history of alimentary tract hemorrhage in 1 month . * 4 prior organ allograft. * 5 women who are pregnant or breastfeeding. * 6 women with a positive pregnancy test on enrollment or prior to nvestigational product administration. * 7 subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness.
changes in central arterial pressure when comparing nifedipine/labetalol for routine hypertension control in pregnancy

Conditions: Hypertension

Summary: to study central blood pressure changes caused by commonly used high blood pressure medications in pregnancy.

central blood pressures in addition to pulse wave velocity will be attained prior to medication, and then every 30 minutes for 4 hours (total of 9 readings). sphygmomanometer readings will be completed at the same time (total readings 9). these readings are all related to the study. nursing will have the opportunity to to record the routine sphygmomanometer readings for their routine vitals if they chose to do so. their participation will be complete after the 4 hour assessment is complete.

Eligibility criteria:
inclusion criteria: * singleton pregnancy * women with hypertensive disease in pregnancy who are currently being treated with nifedipine xl or labetalol exclusion criteria: * multiple pregnancy * currently on multiple anti-hypertension medications * narcotic use * irregular heart rhythms or arrhythmias * peripheral arterial disease, leg artery disease * reynaud's phenomena * intense cold/hypothermia * if there is a wound at location of where central arterial cuff would be placed or tonometer for carotid assessment * known sensitivity to labetalol or nifedipine * severe tachycardia (\>120) * greater than 1st degree heart block * severe asthma * congestive heart failure or heart disease * lupus * inability to adequately monitor bp * currently receiving magnesium sulfate
study to assess the efficacy and safety of dysport® in upper back myofascial pain syndrome

Conditions: Myofascial Pain Syndromes

Summary: the main purpose of this study is to determine which is the best dose of a drug known as dysport to give when treating one's type of upper back pain. the study will also examine the side effects of this treatment and its overall effect on one's disorder.


Eligibility criteria:
inclusion criteria: * moderate-severe pain in upper back * myofascial pain syndrome for more than 6 months * active trigger points in upper back exclusion criteria: * fibromyalgia and other non-myofascial pain conditions of upper back * duration of myofascial pain syndrome no longer than 24 months * steroid injections during previous 3 months * anaesthetic injection at trigger points during previous 1 month

Keywords: myofascial pain syndrome
radio-frequency ablation in knee osteoarthritis by three needles technique

Conditions: Knee Osteoarthritis

Summary: the study is designed to evaluate and compare the efficacy of three needles approach as a new technique in radiofrequency neurotomy of genicular nerve versus the traditional single needle approach as a treatment of advanced knee osteoarthritic pain. primary outcome: 1. pain intensity via the visual analogue score (vas). 2. function and pain via the oxford knee score. evaluated after 6 months of the procedure secondary outcome: 1. failure rate. 2. incidence of any complication. 3. total analgesic requirement during the period of follow up.


Eligibility criteria:
inclusion criteria: * 1- age 35-85 years old 2- patients with stage 3 or higher oa-related radiological changes based on kellgren-lawrence (k/l) rating scale 3- knee pain for at least 3 months 4-patients are clinically unresponsive to conservative treatment modalities (physical therapy and rehabilitation practices, orally administered analgesics and anti-inflammatory drugs). exclusion criteria: * 1- patients with other causes of pain as radiculopathy, neurological disorders or intermittent claudication. 2- previous knee trauma. 3- previous knee surgery. 4- patients received intra-articular injection during the previous three months. 5- acute knee pain. 6- crystal arthropathy. 7- joint effusion. 8- serious neurological or psychiatric disorders. 9- on anticoagulant medication. 10- any other connective tissue disorder that affects the knee joint. 11- skin infection at the site of injection. 12-patient refusal.

Keywords: genicular nerve radio-frequency ablation
reward re-training: a new treatment to address reward imbalance during the covid-19 pandemic

Conditions: Bulimia Nervosa; Bulimia; Atypical; Binge Eating; Binge-Eating Disorder

Summary: in the current study, the investigators will revise our existing 10-session group rrt treatment manual to specifically address the challenges in building social support and enhancing both momentary and sustained reward during the covid-19 pandemic (preliminary aim 1). in months 2-18, the investigators will conduct a small pilot rct that will randomize individuals to receive either 10-sessions of rrt (n=30) or supportive therapy (n=30), both delivered as group-treatments via videoconferencing software. the specific aims of the current study are to confirm the feasibility and acceptability of rrt for eds (primary aim 1), evaluate the ability of rrt to engage critical targets including reward to day-to-day life activities, reward to palatable foods, social isolation, and loneliness (primary aim 2), and provide preliminary estimates of efficacy in reducing ed symptoms at both post-treatment and a 3-month follow-up (primary aim 3). the investigators will also evaluate the impact of rrt on secondary outcome variables including depression, substance use, and quality of life (secondary aim 1).


Eligibility criteria:
inclusion criteria: 1. have experienced 12 or more loss of control episodes within the previous 3 months 2. have a bmi above 18.5 3. are located in the us and willing/able to participate in remote treatment and assessments 4. are able to give consent exclusion criteria: 1. are unable to fluently speak, write and read english 2. have a bmi below 18.5 3. are receiving treatment for an eating disorder 4. require immediate treatment for medical complications as a result of eating disorder symptoms 5. have a mental handicap, or are experiencing other severe psychopathology that would limit the participants' ability to comply with the demands of the current study (e.g. severe depression with suicidal intent, active psychotic disorder)

Keywords: eating disorders bulimia nervosa binge eating disorder binge eating reward re-training supportive psychotherapy
therapeutic yoga to improve function in parkinson's disease

Conditions: Parkinson's Disease

Summary: this is a single blind, randomized, wait-list controlled, phase ii exploratory pilot study.

this is a single blind, randomized, wait-list controlled, phase ii exploratory pilot study utilizing an after-trial embedded mixed methods approach that will examine the efficacy of therapeutic yoga as a rehabilitation strategy for individuals with pd to improve balance and reduce fear of falling (fof). potential participants will have a fof in order to enter the study. an after-trial embedded mixed methods design will be employed in this study and will include the collection of qualitative data to assist in the overall interpretation of the more heavily weighted quantitative trial data. adding qualitative methods will serve as a post-hoc analysis capturing participant perceptions of the relationships between the yoga intervention and various outcomes. more specifically, the qualitative data will aide in explaining the link between the various yoga techniques and mechanisms that participants attribute to improved balance, reduced fof, and other bio-psychosocial outcomes and experiences. qualitative data will be collected using focus group interviews with participants in the yoga group at the end of the class in week 8.

Eligibility criteria:
inclusion criteria: * diagnosis of parkinson's disease with a rating of 1.5-4 on the modified hoehn and yahr scale of parkinson's disease progression * endorsement of fof,44 able to stand and walk 10 meters with or without an assistive device * \>18 years old; able to speak english * score \>4 out of 6 on the short mini mental status exam * able and willing to attend twice weekly sessions for 8 weeks exclusion criteria: * people with self-reported life expectancy \<12 months * inability to attend sessions due to transportation issues * current involvement with other physical activity (including yoga), rehabilitation, or other intervention studies * inability or refusal to provide informed consent

Keywords: yoga function parkinson's disease gait balance