Kornimate/medical-research-clean huggingface dataset:
the effects of health education in cardiovascular diseases prevention and treatment

Conditions: Cardiovascular Diseases

Summary: the purpose of this study is to evaluate the effects of health education given by nurse on out-patient compliance in cardiovascular diseases prevention and treatment.


Eligibility criteria:
inclusion criteria: * first diagnosis cardiovascular disease exclusion criteria: * severe liver and kidney disease or cancer * limb movement disorder * cognitive impairment * history of malignant arrhythmia or severe heart failure patients have a high risk of sudden death * diabetes * cerebrovascular disease * history of atherosclerotic disease hospital

Keywords: out-patient compliance nurse, heath education cardiovascular diseases treatment and prevention
characteristics and outcomes of intensive care unit patients admitted with novel h1n1 influenza or seasonal influenza

Conditions: H1N1 Influenza; Seasonal Influenza

Summary: the purpose of this research study is to collect information on problems that patients with the novel h1n1 influenza and/or the seasonal influenza experience. novel h1n1 flu is also called the swine flu. seasonal influenza is also called the regular flu. the purpose of this study is to collect information from patients who are infected with either the novel h1n1 or the seasonal flu and to determine what makes patients critically ill with these infections. the goal is to develop a registry that will aid investigators in determining specific markers that lead to development of severe illness in these infections.

patients admitted to the medical intensive care unit with either novel h1n1 infection or seasonal influenza infection may be eligible for participation.

Eligibility criteria:
inclusion criteria: * patients admitted to the medical intensive care unit with a diagnosis of novel h1n1 influenza infection or with a diagnosis of seasonal influenza infection. exclusion criteria: * prisoners * refusal of study participation.

Keywords: to evaluate biomarkers that cause critical illness in patients with novel h1n1 influenza and with seasonal influenza.
rct (randomized controlled trial) of iv acetaminophen for post cesarean pain relief

Conditions: Cesarean Section; Pain, Postoperative

Summary: this study is being done to evaluate the scheduled use of intravenous (iv) acetaminophen among cesarean section patients. the study hopes to find out if patients who receive scheduled iv acetaminophen for 48 hours following delivery have lower self-reported pain scores and use less narcotic pain medication than patients who do not receive iv acetaminophen.

see brief summary

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * scheduled cesarean section delivery * patient of trihealth's faculty medical center or tri-state maternal fetal medicine associates * singleton pregnancy * term delivery (greater than or equal to 37 weeks) * spinal/epidural anesthesia with epidural analgesia (duramorph) * use of pfannenstiel incision exclusion criteria: * weight less than 50 kg * allergy to study drugs (acetaminophen, oxycodone, duramorph, nsaids) * multiple gestation pregnancy * cesarean section for pre-term delivery (less than 37 weeks) * fetal anomalies * inability to use epidural duramorph at time of procedure * general anesthesia used * vertical skin incision * opioid addiction * liver dysfunction (hepatitis, hellp (hemolysis, elevated liver enzymes, and low platelet count), preeclampsia)

Keywords: iv acetaminophen cesarean section pain, postoperative
technological innovation in the virtual assistance of patients with uncontrolled arterial hypertension - hyper 2

Conditions: Essential Hypertension; Metabolic Cardiovascular Syndrome; Heart Disease Risk Factors

Summary: the purpose of this study is to evaluate the effectiveness of the use of artificial intelligence in home monitoring in patients with uncontrolled arterial hypertension.

arterial hypertension (ah) is one of the most important cardiovascular risk factors, accounting for 13.5% of all deaths worldwide. mobile health technologies have been applied as an important tool to improve patient engagement and blood pressure (bp) control, as an alternative approach to remote monitoring of hypertensive patients. therefore, it is essential to help patients adopt healthy measures to assist in the daily control of bp. as the barriers to therapeutic adherence are complex and varied, solutions to improve adherence at the population level should be multifactorial. therefore, the use of an application elaborated by artificial intelligence adapted to individual needs and customs, can help in improving therapeutic adherence and provide better bp control in patients with uncontrolled hypertension.

Eligibility criteria:
inclusion criteria: 1. primary arterial hypertension in drug treatment with at least 3 classes of antihypertensive drugs in optimized dose 2. aged between 20 and 65 years 3. blood pressure of the office ≥ 140 and/or 90 mmhg 4. facilities to use mobile and apps exclusion criteria: 1. stroke sequelae 2. cognitive dysfunction

Keywords: remote telemonitoring uncontrolled hypertension artificial intelligent
evaluation of the efficacy of rosuvastatin in daily practice in untreated high risk patients (challenge)

Conditions: Hypercholesterolemia; Coronary Heart Disease; Peripheral Vascular Disease; CVA; Diabetes

Summary: in an observational multi-centre study (challenge), the effects were assessed of starting treatment with low doses of rosuvastatin in statin naive patients with a history of coronary heart disease (chd), peripheral vascular disease (pvd), cerebrovascular accident (cva), transient ischemic attack (tia) or diabetes (dm), on low-density lipoprotein cholesterol (ldl-c) goal achievement. also proportional changes in ldl-c, high-density lipoprotein cholesterol (hdl-c), total cholesterol (tc), triglycerides (tg) and the ratio tc/hdl-c were studied.


Eligibility criteria:
inclusion criteria: * patients eligible for the study were high-risk patients with a documented history of chd, pvd, cerebrovascular atherosclerotic disease, dm ii or dm i with microalbuminuria. ldl-c had to be \> 2.5 mmol/l and the patient did not use any cholesterol lowering medication during the last 3 months preceding inclusion. the specialist made the decision to start treatment with rosuvastatin irrespective of study participation. patient approved to place anonymous results at the disposal of astrazeneca exclusion criteria: * exclusion criteria included patients familiar with muscular pain, myopathy or liver function disorders (inclusive elevation of serum transaminases), patients with familial dyslipideamia like familial hypercholesterolaemia and familial combined hyperlipid

Keywords: cholesterol, coronary heart disease rosuvastatin ldl-c goal hypercholesterolemia
real-world effectiveness and safety study of t-dxd in chinese metastatic breast cancer

Conditions: Breast Cancer

Summary: the aim of this trial is to explore the real-world effectiveness and poteintial predictors in chinese metastatic breast cancer patients.


Eligibility criteria:
inclusion criteria: 1. patients aged over 18 years old. 2. metastatic breast cancer included unresectable locally advanced breast cancer, de novo stage iv breast cancer, and recurrent metastatic breast cancer. 3. plan to receive or has received trastuzumab deruxtecan monotherapy 4. available medical history. exclusion criteria: 1. incomplete medical history. 2. pregnancy or breast-breeding
identification of occupational exposures in patients with ild

Conditions: Occupational Exposure; Interstitial Lung Disease

Summary: diffuse interstitial lung disease brings together a heterogeneous group of pulmonary pathologies, characterized by infiltrating and diffuse lesions of the pulmonary interstitium. the evolving risk of these ild is pulmonary fibrosis, with the development of chronic respiratory failure. the process of the etiological diagnosis of ild results from a multidisciplinary approach (pulmonologists, radiologists, occupational health specialists, anatomo-pathologists, etc...). indeed, the multitude of possible causes of these diseases makes the etiological diagnosis difficult. professional aetiologies are also frequently mentioned : pneumoconiosis, hypersensitivity pneumonitis, as a differential diagnosis. it therefore appears essential to deepen the professional aspect during the diagnostic process for ild. since may 2020, a professional interview has been systematically offered by the occupational pathology consultation center of the hospital center lyon sud, to patients followed by the team of professor vincent cottin, whose file was discussed in a multidisciplinary meeting. the data collected to constitute a database are the following variables: age, sex, diploma, professional course coded in citp (international standard classification of professions) and naf (french nomenclature of activities), occupational exposures, smoking, risk factors non-professionals, clinical elements of ild and elements relating to an occupational disease certificate. this database is anonymized.


Eligibility criteria:
inclusion criteria: * patients with ild. * file discussed in a multidisciplinary meeting since may 2020 at the louis pradel pneumological hospital. * have benefited from a professional interview in the occupational pathology consultation center of the hospital center lyon sud. exclusion criteria: * patients with sarcoidosis.

Keywords: occupational exposure lung fibrosis interstitial lung disease pulmonary fibrosis
effectiveness study of a swedish youth mentoring program

Conditions: Substance Use

Summary: this study aims to investigate the effectiveness of a one-to-one, adult-to-youth primary preventive mentoring program in sweden. outcome domains and criteria for inclusion and exclusion of study participants are elaborated in collaboration with the providing ngo, and the program is given as customary.


Eligibility criteria:
inclusion criteria: * a self-reported need of the youth for additional adult contacts exclusion criteria: * current or past regular use of illicit drugs * repeated delinquent behaviour or single acts of violence against persons * ongoing contacts with psychiatric care or social services

Keywords: youth mentoring effectiveness sweden low-risk youth
evaluation of the efficacy and safety of the sullivan cochlear implant.

Conditions: Hearing Loss, Sensorineural

Summary: the study will be conducted as a prospective, single center, repeat measure, single-arm, open label clinical study

this study is a clinical trial designed to examine the auditory performance improvement in patients with bilateral severe sensorineural hearing loss (70 db hl or greater) by comparing auditory performance before and after cochlear implant surgery. cochlear implants, both imported and domestically manufactured, have already been approved and are in use in the country. these existing devices have also undergone clinical research, comparing and analyzing auditory performance before and after implantation. therefore, this study is designed as a prospective, single-arm, open-label clinical trial. patients who are clinically eligible for cochlear implant surgery and can tolerate the surgery will be asked for their consent and then undergo the cochlear implant procedure. the outcome of the cochlear implant surgery will be evaluated through auditory performance assessments. additionally, adverse effects will be monitored to assess the efficacy and safety of the cochlear implants on auditory function.

Eligibility criteria:
inclusion criteria: * patients with sensorineural hearing loss of 1 side or both sides (70 dbhl) or higher, aged 19 years or older * no previous cochlear implantation history in the ear scheduled for surgery * no contraindications to surgery, such as cochlear agenesis or auditory nerve agenesis, as determined by imaging tests * patients without cancer, autoimmune disease, or neurological disease * patients with a general condition that allows general anesthesia * patients with no abnormalities in personality, depression, anxiety, sociality, or problem drinking tests * use korean * patients who agree to participate in the clinical trial and sign a written consent form however, if the patient is unable to sign, the patient (if able to sign) and guardian (or agent) voluntarily agree to participate in the clinical trial and sign an informed consent form exclusion criteria: * cases where electrode insertion is difficult due to severe internal malformation, cochlear ossification, etc. * cases with cancer or autoimmune disease * cases with a general condition that makes it difficult to tolerate general anesthesia * cases with moderate or higher mental disability or where auditory training is difficult due to the absence of parents or supporters to assist with rehabilitation education * cases deemed inappropriate for this test by the clinical trial manager

Keywords: cochlear implant
acular ls vs. nevanac in post op inflammation following cataract surgery

Conditions: Cataract

Summary: the purpose of this study is to compare the clinical outcomes, safety and efficacy in patients randomized to receive either ketorolac or nepafanac following cataract surgery.


Eligibility criteria:
inclusion criteria: * · male or female \> 18 years of age scheduled to undergo cataract surgery * must be in good general health. patients with systemic diseases will be enrolled only if there are no ocular manifestations of their disease (ie diabetics with normal retinal exams) * ability to provide informed consent and likely to complete all study visits exclusion criteria: * · known contraindication to any study medication or any of their components * uncontrolled systemic disease * required use of ocular medications other than the study medications during the study * abnormal pre-operative octs if obtainable * diabetic patients * use of oral nsaids * patients with ocular disease (macula degeneration, glaucoma, corneal disease) which reduces the potential visual rehabilitation (patients will ocular disease that will no preclude achievement of a 20/20 visual outcome may be included)..
diplegic cerebral palsy and action observation training

Conditions: Diplegic Cerebral Palsy

Summary: in this study, video-based action observation training and live action observation training in children with spastic diplegic cerebral palsy; it was aimed to examine the effect on motor function, activity participation and secondary outcome measures.

the study was designed as a single-blind randomized controlled trial. patients aged 5-14 years with spastic diplegic cerebral palsy will be included. children will be assigned to groups through stratified randomisation; the patients will be divided into 3 groups as experimental and control groups. group 1 (experiment): video-based action observation training in addition to the conventional rehabilitation program, group 2 (experiment): live action observation training in addition to the conventional rehabilitation program, group 3 (control) will receive only the conventional rehabilitation program. the experimental group will receive 20 minutes of action observation training after a conventional physiotherapy program for 20 minutes for 8 weeks, 40 minutes 2 days a week. the control group will receive 40 minutes of conventional treatment. evaluations will be made for each group, before and 8 weeks after the start of the study. gmfm for gross motor function; pediatric berg balance scale for balance function; timed up and go test for functional mobility assessment; gillette functional assessment questionnaire and 1-min walk test to assess functional walking; sit and stand test for functional muscle strength and to evaluate activity participation; the child and adolescent participation questionnaire (casp) will be used.

Eligibility criteria:
inclusion criteria: * being diagnosed with spastic diplegic cerebral palsy, * to be between the ages of 5-14, * to be at gmfcs i, ii and iii levels, * to have the cognitive level to follow the instructions given by the researchers, * iq\> 70 (to be accessed from patient files), * those who do not have serious restrictions in joint movement, exclusion criteria: * children with joint contractures, * not having visual impairment and visual field defect, * children who have had a seizure in the last 6 months or children who cannot be controlled despite seizure medication * those who received botulinum injections 6 months before the study.

Keywords: action observation therapy diplegic cerebral palsy mirror neuron system motor function activity participation secondary outcome measures
ccrt for esophageal cancer.

Conditions: Esophageal Cancer; Concurrent Chemoradiotherapy; Oxaliplatin; Paclitaxel

Summary: this study aimed at assessing the efficiency and safety of concurrent chemoradiotherapy (ccrt) using paclitaxel (ptx) plus oxaliplatin (ohp) in unresectable locally advanced esophageal cancer patients.


Eligibility criteria:
inclusion criteria: 1. cytologically or histologically confirmed esophageal carcinoma 2. age of 20 -80 3. ecog performance status: 0-1; 4. no treatments prior to enrollment; 5. at least one measurable lesion on ct, mri or esophageal barium exam; 6. normal functions of heart, lung, liver, kidney and bone marrow 7. blood exams qualified for chemotherapy, which included hemoglobulin ≥9 g/dl, neutrophil ≥1.5×109/l and platelet (plt) ≥100×109/l, creatinine ≤1.5 unl 8. informed consent signed exclusion criteria: 1. prior treatments of chemotherapy or irradiation; 2. poor bone marrow, liver and kidney functions, which would make chemotherapy intolerable; 3. contraindication for irradiation: complete obstruction of esophagus, deep esophageal ulcer, fistula to mediastinum, or haematemesis; 4. participating in other clinical trials; 5. pregnancy, breast feeding, or not adopting birth control; 6. clinically significant and uncontrolled major medical conditions including but not limited to: active uncontrolled infection, symptomatic congestive heart failure, unstable angina pectoris or cardiac arrhythmia, psychiatric illness/ social situation that would limit compliance with study requirements; any medical condition, which in the opinion of the study investigator places the subject at an unacceptably high risk for toxicities 7. the subject has had another active malignancy within the past five years except for cervical cancer in site, in situ carcinoma of the bladder or non-melanoma carcinoma of the skin;

Keywords: esophageal cancer concurrent chemoradiotherapy oxaliplatin paclitaxel survival toxicity
colonoscopy endoguide in specialist practice

Conditions: Colonoscopy; Pain

Summary: the study includes 700 patients referred for colonoscopy are randomized to colonoscopy with or without endoguide. the study will investigate whether the endoguide improves success rate and the patient's perception of pain.


Eligibility criteria:
inclusion criteria: * informed consent provided exclusion criteria: * informed consent not provided or not possible to obtain

Keywords: colonoscopy endoguide pain perception colonoscopy to the coecum (success rate) patient's perception of pain duration of successful colonoscopies
subcapital and shaft fractures of the 5. metacarpal

Conditions: Fracture

Summary: the purpose of this study is to find out the best treatment for subcapital and shaft fractures of the 5. metacarpal. it is a prospective randomized multicenter study. comparing only fractures dislocated more than 30 degrees. one group will be operated with intramedullary pins and one group will be treated conservatively with reduction and then plaster of paris for 3 weeks. all patients will be followed up after 3, 6 and 12 months.

see above

Eligibility criteria:
inclusion criteria: * voluntarily, only isolated subcapital og shaft fracture of the 5. metacarpal,operated/reduction within 10 days of injury,not intoxicated,degree of fracture dislocation minimum 30 degrees measured on the x-ray. exclusion criteria: * open fractures, fractures of the head of 5. metacarpal/intraarticular fractures, patients who wants to be followed up at hospitals outside the study area, earlier injury of the hand that might have influence on function.

Keywords: 5. metacarpal fracture/fractures subcapital shaft closed
resting energy needs in brain dead patients (resting energy needs in brain dead patients)

Conditions: Brain Death; Brain Injuries; Brain Edema; Brain Hemorrhage

Summary: the study will examine the resting energy need (ree) in patients suffering from brain damage. for the measurement of ree will be used a metabolic computer (which with continuous recording of breath-to-breath volume (vt), respiratory rate (rr) of ventilation per minute volume (mv) ), of inhaled and exhaled gases (o2 and co2) has the ability to calculate the values of vo2, vco2 and with the help of equations the values of ree and rq.

this is a retrospective observational study concerning patients suffering from brain damage. all the patients suffering from brain damage are monitored in order to examine their resting energy needs (ree). for the measurement of ree the metabolic computer (medical graphics, ultima ccm, minneapolis, usa) is used. the main purpose of this study is to reveal the (ree) changing in patients with brain death semiology and examine if the ree changes could be related to the outcome of a patient with intracranial pathology. moreover the study will examine if the changes in ree measurement are related to changes in flow velocities in the midbrain. any measurement shall be preceded by calibration of the metabolic computer pneumotachograph with a 3-liter syringe with an acceptable error of less than 9 ml / lit. the metabolic unit is calibrated for vo2 measurements with two calibration cylinders containing 21% and 12% o2 and for vco2 measurements with calibration gases containing 5% and 0% co2 respectively. the measurement of flow velocities in the middle cerebral artery will be done with the transcranial doppler using a low frequency (2 mhz) ultrasound head after their final diagnosis (brain death or not) the patients' characteristics will be compared according to the categorization as "brain dead" or not.

Eligibility criteria:
inclusion criteria: * adult patients entering the icu * age 18-90 years old * clinical diagnosis of brain damage * gcs \<=8 exclusion criteria: * patients \ 90 years old, * past history cns disease (alzheimer's disease, multiple sclerosis, brain tumor, aneurysm) in the last 3 years * past history of cachexia due to cancer

Keywords: resting energy expenditure (ree) brain death brain injuries