Kornimate/medical-research-clean huggingface dataset:
effect of cafedrine/theodrenaline and urapidil on cerebral oxygenation

Conditions: Cerebral Ischemia

Summary: during clamping of one internal carotid artery for endarterectomy, blood flow through this vessel has to be compensated by collateral arteries including the contralateral internal artery and vertebral arteries. in 7 % of all patients undergoing carotid endarterectomy this collateral flow is not sufficient to maintain adequate cerebral perfusion during clamping and ischemic brain damage is likely to emerge. to maximize cerebral blood flow during clamping, increase of blood pressure is a common procedure and routine at our institution. increasing blood pressure can be enabled by tapering a mixture of cafedrine und theodrenalin (akrinor®) until the designated blood pressure is reached. after declamping, the blood pressure has to be reduced to normal values to avoid postoperative hyperperfusion syndrome. this is enabled by tapering urapidil until normal blood pressure is achieved. it has been shown that cerebral oxygenation measured by near infrared spectroscopy is reduced by intravenous application of norepinephrine. otherwise, intravenous nitroglycerine increases cerebral oxygenation during cardiopulmonary bypass. hence, cafedrine/theodrenalin and urapidil may also have an effect on cerebral perfusion. in this prospective randomized study the effect of cafedrine/theodrenalin and urapidil on cerebral oxygenation measured by near infrared spectroscopy is investigated.


Eligibility criteria:
inclusion criteria: * patients scheduled for carotid endarterectomy exclusion criteria: * cerebral disease
study to assess the efficacy and safety of repeated administration of bim 23a760 in patients with acromegaly

Conditions: Acromegaly

Summary: the purpose of this study is to assess the efficacy of repeated subcutaneous (under the skin) injections at different doses of bim 23a760 on growth hormone and insulin-like growth factor-1 levels in patients with acromegaly after 6 months of treatment.


Eligibility criteria:
inclusion criteria: * igf-1 ≥1.3 x upper limit normal (uln) * nadir serum gh concentration ≥0.4 ng/ml in an oral glucose tolerance test (ogtt) * patient must have documentation supporting the diagnosis of acromegaly, including elevated gh and/or insulin-like growth factor-1 (igf-1) levels. exclusion criteria: * the patient has received long acting somatostatin analogues within 6 months of study entry * the patient has undergone radiotherapy at any time prior to study entry * the time between pituitary surgery (if any) and study entry is less than 6 weeks * the patient suffers from macroadenoma with visual field defects due to chiasmatic compression
prospective cohort study of the body constitution among type ii diabetes mellitus patients

Conditions: Diabetes Mellitus

Summary: by analyzing the relationship between the body constitution and the progression of type ii diabetes mellitus, its morbidities, mortality and the impact of the life quality, we try to provide an useful tool, body constitution, to stratify the patients accordingly for individualized health care.

the study participants are recruited from the diabetes shared care network of the taichung veterans general hospital (taichung, taiwan)

Eligibility criteria:
inclusion criteria: * patient diagnosed as type ii diabetes mellitus by endocrinology specialist. * aged from 20 to 75 years old. * clear conscious, willing to join the program. exclusion criteria: * severe mental illness, which lead to unable to fulfill the questionaire * major surgical intervention,medical events (such as acute myocardial infarction, cerebral vascular accident...et al.,), chemotherapy or radiation therapy within past one month , which made body constitution measurement unavailable.

Keywords: diabetes mellitus body constitution
the impact of inspiratory muscle strength training

Conditions: Ventilator Dependency

Summary: the study is a pre-post test with quasi experimental design. forty-two intubated-adults who had been mechanically ventilated for more than 21 days were selected on the basis of inclusion criteria in respiratory care ward. these patients were classified equally into study group and control group. the experimental group received the intervention of respiratory muscles training 5 times/ a week for 6 weeks. the control group received normal care. the intervention was adjusted trigger sensitivity to 10% of the first recorded maximal inspiratory pressure at the start of training, then increased the ventilator trigger sensitivity and training duration weekly. the largest of ventilator trigger sensitivity is not over 40% of the initial maximal inspiratory pressure and the timing of training duration is no longer than 30 minutes.


Eligibility criteria:
inclusion criteria: * age \>20y/o * vital signs stable * mip \<20cmh2o * ventilator fio2\<40%, peep \<8 * ventilator mode:psv or simv exclusion criteria: * patient or family refuse
mapping the natural history of parenychymal and cerebral perfusion changes in acute ischemic and hemorrhagic strokes

Conditions: Acute Ischemic Stroke; Hemorrhagic Stroke

Summary: study using ultrasound of the brain as a diagnostic tool to differentiate between ischemic stroke and hemorrhagic stroke. correlation of brain perfusion and size of stroke in relation to systemic hemodynamic targets will be assessed on serial scans.

to explore the correlation of brain parenchyma lesions changes and cerebral perfusion parameters as measured by cranial ultrasound transcranial doppler to patient's blood pressure in a continuous fashion and correlate these to clinical and radiological features of cerebral perfusion. this study will lead to answering clinical management questions like is accurate diagnosis of hemorrhagic stroke possible that could be applied to the field evaluation of stroke patients, optimum blood pressure targets for different subsets of population studied ( multifocal disease, collateralized circulation etc), course of fluctuations in cerebral blood flow in response to systemic blood pressure changes or presence of persistent embolic signals in patients with presumed cardio-embolic strokes.

Eligibility criteria:
inclusion criteria: * all adult patients over the age of 18 who present to wake forest baptist hospital, get evaluated in the emergency department and /or admitted to inpatient/intensive care unit and received any neuroimaging ordered by clinical team (head) (ct) (computerized tomography or magnetic resonance imaging) (mri) with diagnosis of acute ischemic or hemorrhagic strokes or stroke mimic or suspicion of intracranial pathology exclusion criteria: * patients with age \< 18 * incarcerate and pregnant patients * penetrating cranial/head trauma or scalp wound

Keywords: hypertension hypotension stroke therapy cerebral perfusion
non-interventional, real life study on satisfaction with lng-ius in spanish young women (18-30 years old) with different parity status and menstrual bleeding pattern

Conditions: Contraception

Summary: the aim of this non-interventional study (nis) is to assess, under real-life conditions, woman's satisfaction with levonogestrel intrauterine system (lng-ius) in a young (18-30 years old (y.o.)) spanish population taking into account their parity status. furthermore, the study is aimed to evaluate the impact of: menstrual bleeding pattern and satisfaction with it at baseline, lng-ius chosen, previously used contraceptive method and reasons for change to/ choice of a lng-ius on overall satisfaction with lng-ius use.


Eligibility criteria:
inclusion criteria: * women in childbearing age, between 18-30 years old. * women who have chosen a lng-ius as contraceptive method, after been adequately counselled by the physician about all contraceptive possible options. * women who have chosen a lng-ius mainly for contraceptive reasons, not due to heavy menstrual bleeding. * women with no desire to conceive for at least within the next 12 months. * women capable of reading and writing exclusion criteria: * women whose main reason to use a lng-ius is not a contraceptive reason. * women with contraindication for lng-ius. * women with previous experience with a ius. * women who have been diagnosed with heavy menstrual bleeding. * women with degenerative or other kind of diseases that could directly negatively impact their daily life. * women who have undergone a hysterectomy or irreversible contraceptive method. * women participating in a clinical trial. * women with a mental illness and unable to make decisions and follow instructions. * women with amenorrhea * women with clinical history of severe dysmenorrhea * women with concomitant medication that may lead changes in bleeding pattern (e.g. antiplatelets and/or anticoagulants)
the effect of experimental knee pain during strengthening exercises on muscle strength gain

Conditions: Muscle Strength

Summary: the purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. it is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.


Eligibility criteria:
inclusion criteria: * aged between 20 to 35 years * healthy * untrained (non-regular exercise participation \[i.e. \< 1 day/week\]) exclusion criteria: * symptomatic musculoskeletal diseases * history of traumatic injuries to muscles, tendons or joints of the lower extremity * knee joint pain within a month prior to enrollment
vilazodone for treatment of geriatric depression

Conditions: Major Depressive Disorder

Summary: the purpose of this study is to examine the effects of vilazodone for the treatment of depression in older adults.

this is a 12-week double-blind comparison of a novel antidepressant, vilazodone, to the gold-standard drug, paroxetine, for the treatment of geriatric depression. we are interested in assessing the difference in response to vilazodone (vlz) compared to paroxetine (par). we hope to detect difference in response in primary outcomes (depressed mood) and secondary outcomes cognition. we are seeking to examine this directly in 80 older adults (60 years of age or older) with major depression with anticipated 60 completers. this proposed trial will serve as a pilot study to estimate the efficacy and tolerability of the drug in older depressed adults, and use this project for dose-finding in this population.

Eligibility criteria:
inclusion criteria: * 60 years of age or older * the presence of a major depressive disorder diagnosed according to the diagnostic and statistical manual of mental disorders (dsm-iv) criteria * a 24-item hamilton depression rating scale (hamd) score of 17 or higher at baseline * mini-mental state exam (mmse) score \> 24. exclusion criteria: * subjects will be excluded if they had any current and/or lifetime history of other psychiatric disorders (except unipolar depression with or without comorbid generalized anxiety disorder), or recent unstable medical or neurological disorders; any disabilities preventing their participation in the study; diagnosis of mild cognitive impairment (mci)/dementia; those with known allergic reactions to paroxetine or vilazodone.

Keywords: depressed geriatric older adults antidepressants depression anxious major depressive disorder mdd
real-time ai-assisted endocyroscopy for the diagnosis of colorectal lesions

Conditions: Colorectal Polyp; Colorectal Neoplasms

Summary: colorectal cancer (crc) is the third most common malignancy and the second leading cause of cancer-related death worldwide. colonoscopy is considered the preferred method of screening for colorectal cancer, and early and resection detection of colorectal neoplastic lesions can significantly reduce colorectal cancer morbidity and mortality. in order to improve the diagnostic accuracy of endoscopy for colorectal lesions, many endoscopic techniques, such as image-enhanced endoscopy, including narrow band imaging (narrow-band imaging, nbi), magnifying endoscopy, pigment endoscopy, confocal laser endoscopy, and endocytoscopy(ec), are applied clinically. however, with the increasing number of endoscopic resection, the costs associated with the pathological diagnosis of endoscopic resection and resection specimens increase year by year. in clinical practice, some non-neoplastic colorectal lesions may not require resection, so it is important to identify the nature of the lesion during colonoscopy. endocytoscopy is a kind of ultra-high magnification endoscopy. combined with chemical staining and narrow band imaging technology, endoscopists can observe the cell nucleus morphology, gland tube morphology and microvascular morphology with the naked eye, so as to avoid pathological examination and realize the purpose of real-time biopsy in the body. however, the judgment of endocytoscopic images needs a lot of experience to improve the judgment accuracy. moreover, endoscopists have certain subjective judgments and errors in the process of judging the results. therefore, artificial intelligence (ai) is proposed for computer-assisted diagnosis in clinic to solve this problem. in the early stage, our center has developed an ai-assisted diagnostic system based on cellular endoscopy to assist the nature of colorectal lesions, but there is still a lack of prospective clinical study to verify the effectiveness of the ai-assisted system. therefore, the investigatorr want to carry out this clinical study to verify the clinical effectiveness of the ai.


Eligibility criteria:
inclusion criteria: * colorectal lesions exclusion criteria: * lesions lacking high-quality images; * inflammatory bowel disease, familial adenomatous polyposis and other special diseases; * submucosal tumors; * pathological diagnosis of inflammatory polyps, peutz-jeghers polyps, juvenile polyps, lymphoma and other pathological types.
gene therapy study in severe haemophilia a patients (270-201)

Conditions: Severe Haemophilia A

Summary: this study is being conducted by biomarin pharmaceutical inc. as an open label, dose escalation study in order to determine the safety and efficacy of valoctocogene roxaparvovec (an adenovirus-associated virus based gene therapy vector in participants with severe haemophilia a.


Eligibility criteria:
inclusion criteria: 1. males 18 years or older with established severe haemophilia a (endogenous fviii level ≤1 iu/dl) as evidenced by their medical history. 2. treated/exposed to fviii concentrates or cryoprecipitate for a minimum of 150 exposure days (eds) 3. greater than or equal to 12 bleeding episodes for patients on on-demand fviii replacement therapy over the previous 12 months. does not apply to patients on prophylaxis 4. no history of inhibitor, and results from a modified nijmegen bethesda assay of less than 0.6 bethesda units (bu) 2 consecutive occasions at least one week apart within the past 12 months 5. sexually active patients must be willing to use an acceptable method of contraception. exclusion criteria: 1. detectable pre-existing immunity to the aav5 capsid as measured by adeno-associated virus 5 (aav5) transduction inhibition (ti) or aav5 total antibodies 2. any evidence of immunosuppressive disorder or active chronic infection including hepatis b, hepatitis c, hiv 3. significant liver dysfunction as defined by abnormal elevation ofliver function tests, or for patients who have undergone liver imaging or biopsy and found to have evidence of grade 3 or higher fibrosis 4. evidence of any bleeding disorder not related to haemophilia a 5. 12. treatment with any investigational product within 30 days prior to the end of the screening period, or any previous exposure to any gene transfer therapy 6. any disease or condition that per the physician's discretion would prevent the patient from fully complying with the requirements of the study including possible corticosteroid treatment outlined in the protocol. the physician may exclude patients unwilling or unable to agree on not using alcohol for the 16-week period following the viral infusion.

Keywords: haemophilia a gene therapy clotting disorders blood disorder blood coagulation disorders, inherited blood coagulation disorders hematologic diseases coagulation protein disorders hemorrhagic disorders genetic diseases, inborn factor viii coagulants aav5 vector
research project on the risk of discomfort, pain, alteration of skin condition in bedpan use by patients and caregivers

Conditions: Nurse-Patient Relations

Summary: the hypothesis is that the current bedpan is not adapted to the diversity of patients encountered. it is necessary to collect the opinions of patients themselves on the current pool in different departments in order to validate our hypothesis. the objective is to evaluate pain in patients with reduced or very reduced mobility caused by the bedpan currently used in current practice through an observational study.

patients with reduced or severely reduced mobility, over 18 years of age, bedridden and requiring the use of a bedpan, estimated hospitalization equal to or greater than 2 days on the ward.

Eligibility criteria:
inclusion criteria: * patient of legal age (age ≥ 18 years). * patient with reduced and very reduced mobility, bedridden requiring the use of a bedpan. * estimated length of hospital stay on the ward ≥ 2 days. * patient affiliated to a social security system. * patient able to understand the protocol. * patient having given oral non-opposition to participate. * patient who has received the study information note. * patient who had never participated in this study. exclusion criteria: * patients with cognitive impairment preventing objective pain assessment or with neurological pathologies. * patients under guardianship, curatorship or safeguard of justice.

Keywords: bedpan discomfort alteration of skin pain
ventilation and perfusion in the respiratory system

Conditions: Respiratory Failure; Respiratory Distress Syndrome, Adult; Critical Illness; Pulmonary Disease; Ventilator-Induced Lung Injury

Summary: respiratory failure occurs when the lung fails to perform one or both of its roles in gas exchange; oxygenation and/or ventilation. presentations of respiratory failure can be mild requiring supplemental oxygen via nasal cannula to more severe requiring invasive mechanical ventilation as see in acute respiratory distress syndrome (ards).it is important to provide supportive care through noninvasive respiratory support devices but also to minimize risk associated with those supportive devices such as ventilator induced lung injury (vili) and/or patient self-inflicted lung injury (p-sili). central to risk minimization is decreasing mechanical stress and strain and optimizing transpulmonary pressure or the distending pressure across the lung, minimizing overdistention and collapse. patient positioning impacts ventilation/perfusion and transpulmonary pressure. electrical impedance tomography (eit) is an emerging technology that offers a noninvasive, real-time, radiation free method to assess distribution of ventilation at the bedside. the investigators plan to obtain observational data regarding distribution of ventilation during routine standard of care in the icu, with special emphasis on postural changes and effects of neuromuscular blockade, to provide insight into ventilation/perfusion matching, lung mechanics in respiratory failure, other pulmonary pathological processes.


Eligibility criteria:
inclusion criteria: * 18 years or older * admitted to uc san diego la jolla or hillcrest campus intensive care units * patient requiring supplemental oxygen (including but no limited to nasal cannula, high flow devices, noninvasive positive pressure ventilation or mechanical ventilation exclusion criteria: * \<18 years * chest wall, anatomical, physical abnormalities, skin integrity issues precluding placement of electrode belt in direct contact with skin * patient is too unstable to position the belt/electrodes or tolerate head of bed changes * confirmed or suspected intracranial bleed, stroke, edema * active implants (i.e. implantable electronic devices such as pacemakers, cardioverter defibrillators, neurostimulators) or if device compatibility is in doubt * pregnant or lactating patients as safety and efficacy for use of eit in such cases has not been verified
spiriva® in patients with chronic obstructive pulmonary disease (copd) in daily practice

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: post-marketing surveillance to gather information regarding the tolerance and efficacy of spiriva® 18 micrograms in patients with copd under conditions of daily practice.


Eligibility criteria:
inclusion criteria: * men and women aged at least 40 years with the symptoms of chronic obstructive pulmonary disease exclusion criteria: * patients with the general and specific contraindications listed in the patient information leaflet and the basic product information
diets with a spectrum of fat intake for preventing obesity: a randomized controlled-feeding trial

Conditions: Healthy

Summary: the aim of the current study is to evaluate the effects of diets with three levels of dietary fat on weight change and related cardiometabolic risk factors in a 6-month randomized controlled-feeding trial.


Eligibility criteria:
inclusion criteria: * students in zhejiang university or working stuff in the chinese pla general hospital * 18 ≤ age ≤ 35 * body mass index \< 28\* * are willing to eat all of the study foods even when full * are willing to eat only foods provided * are willing to avoid strenuous activity during the 6-mo intervention exclusion criteria： * systolic blood pressure ≥ 140 mmhg or diastolic blood pressure ≥ 90 mmhg * total cholesterol ≥ 239 mg/dl * low-density lipoprotein cholesterol ≥ 159 mg/dl * triglycerides ≥ 199 mg/dl * blood glucose ≥ 110 mg/dl * change in body weight exceeding ± 10% during the prior year * energy intake is too low or too high * unwillingness or special requirement for diet that could not be modified * poor adherence during the recruiting meeting or unsatisfactory completion of keeping food diary or filling questionnaire at any time before randomization * eating disorder or any psychosocial or scheduling factors that could impede study outcomes * have a history of diagnosed cvd, diabetes, cancer or inflammatory diseases * have a history of a mental illness * have diagnosed endocrine, pulmonary or hematological disease * have diagnosed bowel disease or malabsorption that would prevent the participants from complying with the dietary restrictions of the feeding trial * renal or liver insufficiency * other chronic disease thought to interfere with the effect of the diet or with participation or adherence * current use of supplements or anti-inflammation medications or medications affecting glucose, lipid metabolism and blood pressure * smoking or alcoholic beverage intake \>1 times per week * current or planned pregnancy prior to end of study, or breast-feeding * irregular menstrual cycles * have birth control medication

Keywords: weight change diet dietary fat feeding design