Kornimate/medical-research-clean huggingface dataset:
preoperative education in hand and wrist surgery

Conditions: Distal Radius Fracture

Summary: this study will compare opioid consumption in patients undergoing outpatient surgical fixation of distal radius fractures with and without standardized preoperative education at grady memorial hospital.

the proposed research aims to study the impact of preoperative education on postoperative pain control after outpatient surgery for traumatic wrist fractures. the impact of preoperative education will be studied through patient questionnaires and by tracking postoperative opioid consumption as well as instances of unscheduled healthcare contact after surgery. the study will be a randomized controlled trial. this study imposes no more than minimal risk to study participants. loss of privacy and breach of confidentiality are risks of this study. all data will be stored securely on microsoft one drive, a password-protected, encrypted database which requires two-factor authorization. the study population will be patients aged 18-99 years who are undergoing outpatient surgical management of distal radius fractures at grady memorial hospital. no vulnerable populations will be included. contact will be made with potential study participants at their preoperative clinic visit. written informed consent will be obtained. data will not be publicly available. data will be deidentified, and no members of the team will have access to the code that identifies patients. data will be collected in the plastic surgery clinic, orthopedic surgery clinic, and preoperative area at grady memorial hospital. the total respondent burden will be 30 minutes.

Eligibility criteria:
inclusion criteria: * any patient over the age of 18 years with a closed carpal, metacarpal, or distal radius fracture undergoing outpatient surgical management at grady memorial hospital, who is willing to participate and mentally capable to consent. exclusion criteria: * patients who are inpatients at the time of surgery. patients who have concomitant injuries on the same extremity as the carpal, metacarpal, or distal radius fracture. patients with open fractures. patients unable to tolerate non-steroidal anti-inflammatory drugs (nsaids). non-english speaking patients will be excluded. * adults who are unable to consent will not be included. * individuals who are not yet adults will not be included. * pregnant women will not be included. * prisoners will not be included. * cognitively impaired individuals or individuals with impaired decision-making capacity will not be included. * individuals who speak english will be included. individuals who have limited english proficiency but speak spanish as a primary language will not be eligible for inclusion. spanish-speaking patients will be excluded because the components of the educational protocol (video, questionnaires, surveys) are not available in spanish.

Keywords: orif
study on music intervention of non-clinical college students

Conditions: Depression Anxiety Disorder

Summary: the purpose of this trial is to understand whether a mindfulness-integrated volleyball team sports program can effectively intervene in the mental health of college students. the main questions it aims to answer is: does the music group effectively intervene in the participants' mental health levels, including indicators such as anxiety and depression? participants will: attend a music group once a week for 1.5 hours each session, for a total of 6 weeks. complete a psychological questionnaire every 3 weeks and a follow-up questionnaire every 2 weeks after the program concludes for twice.


Eligibility criteria:
inclusion criteria: * participants aged 16 years or older. * able to communicate in mandarin and voluntarily participate in the study. * agree to consistently participate in each session. exclusion criteria: * disagree to consistently participate in each mindfulness-integrated volleyball course. * individuals unable to commit to participating in each mindfulness-integrated volleyball course.

Keywords: music therapy
vocal-cord vs. complete laryngeal radiotherapy for early glottic cancer

Conditions: Cancer Neck; Larynx Cancer; Glottis Tumor

Summary: this is a multicentrer, randomized bayesian phase ii trial for patients with early stage (t1n0) glottic squamous cell carcinoma treated with radical radiotherapy. the primary objective is to assess the non-inferiority of local control achieved with vocal-cord only radiotherapy (vc-rt) compared to complete larynx radiotherapy (cl-rt) in t1n0 glottic laryngeal squamous cell cancer, measured at 2-years after treatment. secondary outcomes include overall survival, as well as voice impairment, dysphagia and quality of life, measured respectively by the voice handicap index -10 (vhi-10), the md anderson dysphagia inventory (mdadi) and the md anderson symptom inventory- head and neck module (mdasi-hn). patients will be randomized in a 1:3 ratio to cl-rt (39 patients) and vc-rt (116 patients) arms. there will be stratification by tumor stage (t1a/t1b) and by institution. an interim analysis is planned after the first 55 patients enrolled on the experimental arm have a 6-month follow-up.


Eligibility criteria:
inclusion criteria: * stage t1a-b n0 of the true vocal cords planned for definitive rt * patient not candidate for laser surgery or declined laser surgery * biopsy-confirmed squamous cell carcinoma, including verrucous carcinoma * eastern cooperative oncology group performance status 0-2 * ability to provide written informed consent. exclusion criteria: * previous irradiation of the head and neck (hnc) region * pregnancy or breastfeeding * any medical condition that represents, in the opinion of the investigator, a contraindication to radiotherapy or would prevent follow-up after radiotherapy. * prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 2 years.
carpal tunnel syndrome treatment: surgery vs. injections

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: this prospective randomized controlled study included 68 patients (aged 18-70) with mild to moderate carpal tunnel syndrome (cts), randomized into three groups: surgical treatment (25 patients, 25 wrists), corticosteroid (cs) treatment (20 patients, 32 wrists), and platelet-rich plasma (prp) treatment (23 patients, 35 wrists). diagnosis was confirmed through clinical evaluation and electrodiagnostic (edx) testing, with assessments including the visual analog scale (vas), boston carpal tunnel questionnaire (bctq), ultrasonographic median nerve cross-sectional area (csa) and flattening ratio (fr), and sensory/motor conduction parameters. treatments were ultrasound-guided cs (1 ml triamcinolone, 40 mg/ml) or prp (1 ml extracted from centrifuged venous blood) injections, while surgical treatment involved standard open carpal tunnel release using the walant (wide awake local anesthesia no tourniquet) technique. follow-ups were conducted at 1, 3, and 6 months, and the study was ethically approved with informed patient consent.


Eligibility criteria:
inclusion criteria: minimum of 3 months duration of symptoms and mild to moderate cts exclusion criteria: * 1) patients with severe cts diagnosed with emg or the presence of thenar atrophy, 2) polyneuropathy, 3) previous injection therapy for cts, 4) previous cts surgery, 5) pregnancy or lactation.
comparison of clinical outcomes after cataract surgery with and without capsular tension ring

Conditions: Cataract

Summary: this study was set up to identify clinical outcomes including a refractive shift or change in iol calculation accuracy and optical quality after ophtec® capsular tension ring in the eyes without zonular instability.


Eligibility criteria:
inclusion criteria: 1. age between 40 and 79 years 2. no history of eye surgery or glaucoma 3. a transparent central cornea 4. pupil dilation at the preoperative examination of at least 6.0 mm 5. absence of biomicroscopic signs of pseudoexfoliation 6. normal fundus examination exclusion criteria: 1. presence of ocular disease that might affect the visual outcome (e.g., color vision disturbance, chronic uveitis) 2. presence of ocular disease that might affect contrast sensitivity function (e.g., glaucoma, maculopathy, high myopia)
acute pancreatitis patient registry to examine novel therapies in clinical experiences 2

Conditions: Pancreatitis

Summary: this study is an ancillary of apprentice. this will be the international based study.

this study is an ancillary of apprentice. this will be the international based study. the initial study design with discussions about the different variables to be included into our prospective database started during 2014 pancreasfest held in pittsburgh, pa in late july 2014 under the sponsorship of collaborative alliance for pancreatic education and research (caper). following this, a datasheet with variables was created, distributed through the initial participants, and further suggestions and edits were made. we now plan to move ahead with a web based seminar. all previous participants, as well as new investigators/centers that have shown interest in participating throughout the world will be invited.university of pittsburgh will be responsible for collecting all required regulatory documents from other sites. developing templates for questionnaires and other data collection forms. will train approved sites on procedures. the coordinating center will be the recipient of de-identified data and will not be involved in the collection of data. note that copies of training records, licenses, certificates should be maintained in the study regulatory binder and are subject to audit by the research conduct and compliance office (rcco).

Eligibility criteria:
inclusion criteria: 1. the diagnosis of ap based upon presence of two out of the three following criteria: 1. abdominal pain typical to ap 2. serum amylase or lipase levels more than three times the upper limit of normal 3. imaging findings suggestive of ap 2. willingness to participate in the study and ability to sign informed consent by patient or his/her proxy (if unable to speak). exclusion criteria: 1. age under 18 years 2. unwilling to provide consent by patient or his/her proxy 3. presence of pancreatic cancer 4. presence of chronic pancreatitis 5. occurrence of ap following a multiple trauma episode 6. having history of organ transplant 7. presence of any cancer which required chemotherapy or radiation therapy in the past year.
feasibility of neostigmine for intraoperative neuromonitoring in thyroid surgery

Conditions: Thyroid Diseases; Surgical Injury; Nerve Monitoring

Summary: for successful intraoperative neuromonitoring (ionm), adequate reversal of neuromuscular blocking agent is a prerequisite in thyroid surgery with . the aim of this study is to investigate the feasibility of neostigmine just after tracheal intubation on the ionm in thyroid surgery.

for successful intraoperative neuromonitoring (ionm), adequate reversal of neuromuscular blocking agent is a prerequisite in thyroid surgery with . the aim of this study is to investigate the feasibility of neostigmine just after tracheal intubation on the ionm in thyroid surgery. this study will be performed as a randomized controlled trial with two groups (n group: neostigmine group and ns group: normal saline group). for the n group, neostigmine (0.03 mcg / kg) and glycopyrrolate with a 5:1 ratio will be administered just after tracheal intubation. for the ns group, normal saline with a same volume of the n group will be administered just after tracheal intubation. for all patients of two groups, investigators evaluate the quality of signal of ionm during the surgery.

Eligibility criteria:
inclusion criteria: * open thyroid surgery with intraoperative neuromonitoring exclusion criteria: * refusal to participate in the study * rocuronium should not be used (e.g. renal dysfunction patient)

Keywords: thyroid surgery recurrent laryngeal nerve neostigmine intraoperative neuromonitoring
a study of tak-861 in people with narcolepsy type 1

Conditions: Narcolepsy Type 1

Summary: the main aim of this study is to learn how effective tak-861 is in improving excessive sleepiness during the day (called excessive daytime sleepiness or eds) after 3 months of treatment. other aims are to learn how effective tak-861 is in lowering the number of sudden, unexpected attacks of muscle weakness while staying conscious (cataplexy) in a week; to learn the effect tak-861 has on participants' ability to maintain attention, participant's overall quality of life, the spectrum of narcolepsy symptoms and daily life functions; and to learn about the safety of tak-861.

the drug being tested in this study is called tak-861. tak-861 is being tested to evaluate its efficacy and safety in participants with narcolepsy with cataplexy (narcolepsy type 1 \[nt1\]). the study will enroll approximately 93 participants. participants will be randomly assigned (by chance, like flipping a coin) to one of the two treatment groups: 1. tak-861 2. placebo the study drug will be administered for 12 weeks. this multi-center trial will be conducted globally.

Eligibility criteria:
inclusion criteria: 1. the participant has a body mass index (bmi) within the range 18 to 40 kilograms per meter square (kg/m\^2). 2. the participant has an international classification of sleep disorders, third edition (icsd-3) or international classification of sleep disorders, third edition, text revision (icsd-3-tr) diagnosis of nt1. 3. the participant has greater than or equal to (≥)4 partial or complete episodes of cataplexy/week (wcr). 4. the participant is positive for the human leukocyte antigen (hla) genotype hla-dqb1\*06:02 or results from radioimmunoassay indicate the participant's cerebrospinal fluid (csf) orexin (ox)/hypocretin-1 concentration is less than or equal to (≤)110 picograms per milliliter (pg/ml) \[or less than one-third of the mean values obtained in normal participants within the same standardized assay\]. exclusion criteria: 1. the participant has a current medical disorder, other than narcolepsy with cataplexy, associated with eds. 2. the participant: (a) has a history of myocardial infarction; (b) has a history of clinically significant hepatic disease, thyroid disease, coronary artery disease, cardiac rhythm abnormality or heart failure; or (c) has any medical condition (such as unstable cardiovascular, pulmonary, renal or gastrointestinal disease). 3. the participant has current or recent (within 6 months) gastrointestinal disease that is expected to influence the absorption of drugs. 4. the participant has a history of cancer in the past 5 years. 5. the participant has a clinically significant history of head injury or head trauma. 6. the participant has a history of epilepsy, seizure, or convulsion. 7. the participant has any current unstable psychiatric disorder or current active major depressive episode (mde) or an active mde in the past 6 months.

Keywords: drug therapy
clinical effect of no-touch harvesting technique in opcabg

Conditions: Coronary Artery Disease; Graft Failure

Summary: this study aims to investigate the clinical effect of the new saphenous vein harvesting technique "no-touch" in off-pump coronary artery bypass grafting(opcabg), comparing to the conventional technique. adopting cta to evaluate the 3 months patency of the graft, we will compare veins harvested using no-touch technique to saphenous veins using conventional open technique.

coronary artery disease(cad) is a widespread health issue around the world. it is proven that atherosclerosis is a inflammatory disease, and endothelial dysfunction is one of the key factors that initiates the inflammatory response. accumulating studies indicate that endothelial homeostasis plays a primordial role in the development of atherosclerosis. coronary artery bypass grafting(cabg) is the standard treatment of three-vessel or left main coronary artery disease, and its long-term benefits is apparent. saphenous vein is the most common graft in cabg, however, the long-term patency is only about 50% in one year, as a result, it is urgent to discover a solution to improve the long term potency of vein grafts. conventional harvesting technique dissects the perivascular tissue and inject saline to check leakage, which causes damages to the endothelium of the vein, initiating inflammatory response. no-touch technique is a atraumatic, non-distended harvesting technique. according to the criteria, we will randomize the patients into two groups, the conventional and no-touch group, the vein will be used in sequential anastomosis, by comparing the 3 months patency rate assessed by cta, we aim to compare the clinical outcomes of the two different vein harvesting techniques.

Eligibility criteria:
inclusion criteria: * patients from northern china * first time isolated off-pump coronary artery bypass graft * echocardiogram show that ejection fraction is over 35% * the diameter of saphenous vein ≥ 2mm * the vein graft will be used in sequential anastomosis, and the anastomosis sites ≥2 * be able to sign informed consent form exclusion criteria: * patients who need to undergo urgent surgery * severe renal insufficiency(creatinine \>200 umol/l) * allergic to radiocontrast agent * vein is used to isolated anastomosis * combined with malignant tumor or other severe systemic conditions

Keywords: coronary artery disease coronary artery bypass grafting vein graft failure endothelial dysfunction
level of lacrimal passage obstruction

Conditions: Lacrimal Apparatus Diseases

Summary: detect anatomical level of acquired lacrimal passage obstructions among patients with epiphora. they were evaluated and divided into four groups punctal, canalicular, nasolacrimal duct and mixed groups according to level of obstruction

in a 3 years period adult patients with obstructive epiphora were evaluated clinically by probing /irrigation of lacrimal passages to detect anatomical level of obstruction. the main site of obstruction was the common canaliculus where 2/3 of patients had canalicular problems. the second common site of obstruction is nasolacrimal duct followed by the puncti.

Eligibility criteria:
inclusion criteria: * watering of the eye * acquired lacrimal obstructions * adult patients with exclusion criteria: * no previous lacrimal surgery * congenital lacrimal obstructions
buspirone plus omeprazole for functional dyspepsia

Conditions: Dyspepsia

Summary: this study is a double-blinded randomised clinical trial aim to compare buspirone plus omeprazole with placebo plus omeprazole.


Eligibility criteria:
inclusion criteria: * being over 18-year-old, rome iii criteria for fd * normal upper endoscopy within five years * negative urease test for h-pylori * acceptance informed concept form. exclusion criteria: * denied to get these medications * taking other drugs for fd * patients with the organic gastrointestinal disorder

Keywords: functional dyspepsia
prophylactic use of entecavir for hbsag negative/hbcab positive/hepatitis b virus dna negative patients with lymphoma

Conditions: Hepatitis B

Summary: the purpose of this study is to identify the effect of prophylactic entecavir in hbsag negative/hbcab positive/hepatitis b virus dna negative patients with lymphoma.

the purpose of this study is to identify the effect of prophylactic entecavir in hbsag negative/hbcab positive/hepatitis b virus dna negative patients with lymphoma are randomized into entecavir prophylaxis group or observation group. in entecavir prophylaxis group, entecavir 0.5 mg/day orally is initiate on day 1 of the first course of antitumor therapy, and will be continued until at least 6 months after completion of antitumor therapy. in observation group, entecavir 0.5mg daily will be prescribed for patients with hepatitis b virus reactivation.

Eligibility criteria:
inclusion criteria: * treatment-naive patients with lymphoma * hbsag negative/hbcab positive/hepatitis b virus dna negative at baseline * treated with chemotherapy and/or immunosuppressive therapy * life expectancy of more than 3 months exclusion criteria: * younger than 18 years old * hbsag positive or hbcab negative or hepatitis b virus dna positive at baseline * pregnant or lactating women

Keywords: lymphoma hepatitis b virus therapeutic uses antiviral agents
tdcs response prediction using eeg in stroke

Conditions: Stroke; Rehabilitation; Transcranial Direct Current Stimulation; Motor Recovery

Summary: patients with chronic stroke (\>6 months after stroke) having unilateral upper limb hemiparesis will be recruited. patients will maintain their usual inpatient rehabilitation including occupational therapy. at baseline (t0) and after 2weeks of enrollment (t1), fugl-meyer assessment (fma) will be assessed at each time. and patients with the changes of fma between t0 and t1 less than 3 points will be finally recruited. the enrolled patients will receive additional 30-min cathodal transcranial direct current stimulation (tdcs) over the contralesional motor cortex for 10 consecutive weekdays, with maintaining their usual conventional rehabilitation. at t1 and immediately after 10-seessions of tdcs (t2) and 1 month after completing 10-tdcs session (t3), fma, actional research arm test (arat), box and block test (bbt) and electroencephalography (eeg) were measured.


Eligibility criteria:
inclusion criteria: * age ranges from 19 to 85 yrs old * stroke patients with unilateral hemiparesis * 1st ever stroke * chronic stroke (\>6 months after stroke) exclusion criteria: * recurrent stroke * history of traumatic brain injury * minimental state examination score is 15 or less. * unstable medical conditions * severe delirium, disorders of consciousness * pregnancy * can not attach tdcs electrode on the scalp due to skin conditions * can not maintain the sitting position * intracranial metals