Kornimate/medical-research-clean huggingface dataset:
psychometric evaluation of the ippaq in pediatric patients with sickle cell disease hospitalized with vasoocclusive pain

Conditions: Sickle Cell Disease; Pain

Summary: historically, sickle cell disease has not been viewed in the chronic pain paradigm because of its recurrent nature. patients with sickle cell disease may be hospitalized for extended periods of time. as the hospital stay progresses, patients with scd pain are often observed by clinicians to have improvements in function in areas such as self-care, mobility, and recreation despite continued self-report of high pain scores. this pattern of functional improvement with continued report of high pain intensity scores is common in patients with recurrent and chronic pain. a functional assessment tool that can assess function in the acute inpatient setting is needed. the purpose of this study is to evaluate the inpatient pediatric physical activity questionnaire (ippaq), as a measure of daily function in children with sickle cell disease hospitalized with vasoocclusive pain.

refer to brief summary

Eligibility criteria:
inclusion criteria: * documented sickle cell disease * sudden onset of pain consistent with vasoocclusive episode at the time of hospitalization. * pain requiring hospitalization and placement on standard clinical guideline for management of acute pain in sickle cell disease during hospitalization * cognitive ability to report pain on a 0-10 numerical rating scale (nrs) * parental/patient consent and child assent exclusion criteria: * primary diagnosis other than vasoocclusive pain * concurrent acute chest syndrome (acs) * patient previously enrolled in this study * inability to understand english

Keywords: sickle cell disease pain assessment
safety of hyaluronan thiomer i.o. implant during combined phacoemulsification - non penetrating deep sclerectomy

Conditions: Open Angle Glaucoma; Cataract

Summary: the study is designed to assess the safety of hyaluronan thiomer i.o. implant in patients with primary open angle glaucoma undergoing a combined phacoemulsification - non penetrating deep sclerectomy procedure. in this study, hyaluronan thiomer i.o. will be implanted during a combined surgery of cataract and non - penetrating deep sclerectomy in a group of 16 patients with primary open angle glaucoma and clinically significant cataract. given that a considerable number of glaucoma patients also suffer from cataract, it is reasonable to test hyaluronan thiomer i.o. during a combined procedure of phacoemulsification and deep sclerectomy. this is also of importance because a combined procedure avoids the need of a second operation in this group of patients. finally, it has been shown that combined phacoemulsification - deep sclerectomy does not induce a further risk compared to deep sclerectomy alone(open phase i study). safety will be assessed based on the occurrence of adverse events. efficacy assessments will be performed at every visit and efficacy analysis will include: * proportion of subjects at each study time point which will need additional iop lowering drug therapy to achieve an iop reduction to values \< 21 mmhg. if a subject needs more than one drug to achieve target iop, the number of drugs needed to achieve adequate iop reduction will be recorded. * proportion of subjects at each time point which will need neodymium:yag goniopuncture to achieve an iop reduction to values \< 21 mmhg.


Eligibility criteria:
inclusion criteria: * men and women aged over 18 years * primary open angle glaucoma with uncontrolled iop (iop \> 21 mmhg or more) despite maximally tolerated topical medication * clinically significant cataract as judged by the investigator * scheduled for combined cataract/glaucoma surgery exclusion criteria: any of the following will exclude a subject from the study: * participation in a clinical trial in the 3 weeks preceding the study * presence or history of a severe medical condition as judged by the clinical investigator * wearing of contact lenses * loss of mean deviation of visual field testing of 15 db or more * diabetic retinopathy * dysgenetic glaucoma, secondary glaucoma or any type of angle closure glaucoma * previous argon laser trabeculoplasty * severe dry eye syndrome as judged by the investigator * ocular infection or clinically significant inflammation as judged by the investigator * ocular surgery in the 12 months preceding the study * history of glaucoma surgery in the study eye * neovascular form of age related macular degeneration * the following lenses will not be implanted during cataract surgery multifocal lenses toric lenses pmma lenses * ametropy \>/= 6 dpt * patients in which the surgical procedure cannot be performed or completed according to the protocol for any reason will be excluded and replaced. * pregnancy, planned pregnancy or lactating

Keywords: open angle glaucoma cataract
secondary care - prescribing lifestyle adjustments for cardiovascular health (s-plac 2)

Conditions: Cardiovascular Diseases; Cardiovascular Risk Factor; Health Behavior

Summary: prescribing lifestyle changes to patients who have cardiovascular disease (cvd) may be an extremely cost effective mechanism of improving health individually and for the nhs. positive lifestyle changes such as improved diet, increased physical activity, quitting smoking and reducing alcohol consumption have been proven to reform the health status of individuals with cvd. s-plac 2 is a phase ii study to determine the efficacy of a lifestyle prescription (l℞) in patients and healthcare practitioners in a secondary care setting (i.e. hospital clinics/wards).


Eligibility criteria:
inclusion criteria: * age 18 and over * able and willing to provide written informed consent * understands written and spoken english * either an in/out- patient of cardiology exclusion criteria: * participant is unwilling or unable to provide written informed consent * participant is pregnant * participant has a drug dependency
randomized trial of mobilized blood/marrow versus blood transplant

Conditions: Leukemia

Summary: the use of peripheral blood stem cells(pbscs) is rapidly growing in the allogeneic transplantation setting as an alternative to bone marrow (bm).it was found that the use of pbscs is associated with faster hematologic recovery but have yielded differing results regarding the incidence of graft-versus-host-disease (gvhd) and relapse. the study hypothesis: transplantation of mobilized pbsc to haploidentical donor with standard-risk leukemia had comparable engraftment and non-relapse mortality to mobilized bm combined with pbscs

the donors were primed with granulocyte-colony stimulating factor (g-csf) injected subcutaneously for five consecutive days. in the trial group, the pbscs were harvested on the fourth and fifth day;in the control group, the bone marrow cells were harvested on the fourth day and the pbscs were harvested on the fifth day.

Eligibility criteria:
inclusion criteria: * standard risk of recipients of haploidentical stem cell transplantation with myeloablative conditioning regimens exclusion criteria: * active, uncontrolled infection
long-arm vs sugar-tong

Conditions: Closed Fracture of Shaft of Ulna; Closed Fracture of Shaft of Radius

Summary: the purpose of this study is to determine whether a sugar-tong splint is as effective as a long-arm cast in maintaining reduction of pediatric forearm shaft fractures in a randomized, prospective manner. consented participants will be randomly assigned to be treated with either a sugar-tong splint or a long-arm cast (both standard of care treatments) in redcap. each participant will have a 50/50 chance of being assign to either treatment.

forearm fractures are very common in the pediatric population and can often be treated with closed reduction and immobilization. immobilization techniques include long-arm casting, short-arm casting and sugar-tong splinting. at the time of injury casts are usually split into two using a cast saw, known as bivalving, to allow for swelling and are overwrapped at a later time. by design sugar-tong splints allow for swelling and are overwrapped or converted to a cast at a later time. traditionally long-arm casts have been used as the standard mode of immobilization for forearm fractures. recent evidence demonstrates that long-arm casting is equivalent to better tolerated short-arm casting as an immobilization choice for distal third forearm fractures.1 further work has shown that sugar-tong splints are also appropriate for treatment of distal third forearm fractures. no study has compared the efficacy of using a long-arm cast versus a sugar-tong splint for treatment of forearm shaft fractures.

Eligibility criteria:
inclusion criteria: * single or both bone forearm shaft fractures, follow-up at the st. louis children's hospital and affiliated branches exclusion criteria: * children below 4 or above 12 years of age * distal radius/ulna fracture(s) * distal radius/ulna third shaft fracture(s) * proximal radius/ulna third shaft fracture(s) * radius/ulna fracture(s) not requiring reduction * open radius/ulna fracture(s) * radius/ulna fracture(s) requiring open reduction in the operating room * patient with metabolic defects * pathologic radius/ulna fracture(s) * previous fractures in the same location (radius/ulna)

Keywords: closed reduction sugar-tong splint long-arm cast
measurement of oncostatin m, leukemia inhibitory factor and interleukin-11 levels of patients with periodontal disease

Conditions: Chronic Periodontitis, Generalized; Gingivitis

Summary: this study aims to determine oncostatin m (osm), leukemia inhibitory factor (lif), and interleukin-11 (il-11) levels in gingival crevicular fluid (gcf), saliva, and serum in periodontally healthy individuals and those with gingivitis and chronic periodontitis before and after periodontal treatment and to evaluate the relationship between these cytokine levels and clinical periodontal parameters.


Eligibility criteria:
inclusion criteria: * systemically healthy * non-smokers exclusion criteria: * smokers * pregnancy or lactation * individuals with any systemic disease * individuals who have had periodontal treatment in the last six months

Keywords: chronic periodontitis gingival crevicular fluid leukemia inhibitory factor oncostatin m interleukin-11 periodontal therapy gingivitis
the regulatory role of immune response in oral lichen planus

Conditions: Oral Lichen Planus

Summary: oral lichen planus (olp) is a common chronic inflammatory disease of oral mucosa. the pathogenesis of olp is not clear, and there is no effective method to cure it. in vitro, previous studies have shown that oral mucosal mesenchymal stem cell cells (mscs) can secrete ido, which is involved in the pathogenesis of olp. it has been proved that mental disorders such as depression and anxiety play an important role in the pathogenesis and treatment of olp. mental stress factors can cause abnormal changes of inflammatory factors, leading to immune dysfunction, which is also one of the main causes of olp. in this study, we integrated the advantages of stomatology, psychiatry, neurobiology and traditional chinese medicine, focused on the clinical problems of mental disorders with oral mucosal comorbidity, and assessed the depressive and anxiety status of olp patients, so as to improve the therapeutic effect of olp.


Eligibility criteria:
inclusion criteria: * patients with oral lichen planus * male or female patients older than 18 years of age * patients willing to participate with signed informed consent. exclusion criteria: * pregnant or lactating * had serious systemic diseases of the heart, lung, liver, and kidney, or had tumors * were unwilling to participate in the experiment.

Keywords: oral lichen planus depression anxiety mesenchymal stem cells
non-influenza etiologies of acute respiratory illness in southeast asia

Conditions: Lower Respiratory Tract Infection

Summary: acute respiratory infection (ari) constitutes a leading cause of morbidity, hospitalization and mortality worldwide. the most common etiologic agents of ari's, especially in children, are viruses. the study objective is to determine the viral and bacterial etiologies of aris in patients with lower respiratory tract infection in south east asia. this is a laboratory based surveillance study, in which the archival specimens from hospitalized patients will be tested for respiratory pathogens other than influenza viruses standard descriptive statistics will be used to present the findings

this study will test 1400 specimens from 1200 patients at the following laboratories: * national hospital of pediatrics, hanoi * national institute of infectious and tropical diseases, hanoi * siriraj hospital, bangkok * national institute of health research and development, jakarta * hospital for tropical diseases, hcmc * children hospital #1, ho chi minh city * children hospital #2, ho chi minh city * queen sirikit national institute of child health

Eligibility criteria:
inclusion criteria: * adequately stored respiratory specimens obtained from hospitalized patients suspected of lower respiratory tract infection and were tested for influenza. exclusion criteria: * specimens stored at insufficient temperature * specimen volume is insufficient * no demographic data available * specimen unsuitable for testing for other technical reasons

Keywords: lower respiratory tract infection non influenza pcr assay
turkish of the sars-cov-2 anxiety scale

Conditions: Anxiety; SARS-CoV Infection

Summary: the coronavirus outbreak has adversely affected individuals in the community, as in the rest of the world. however, in order to carry out this epidemic period in a healthy and conscious manner, determining the anxiety levels of individuals in the society and supporting them psychologically is of great importance. in order to achieve this, healthcare professionals working clinically or academically have important duties. this study was planned to test its validity and reliability in order to adapt the coronavirus anxiety scale to turkish.

coronaviruses can be seen in animals and humans as infections that can be mild and severe in society. the sars-cov-2 virus, a type of coronavirus, started in china in december 2019 and has spread worldwide as of january 2020. the absence of vaccine and treatment for sars-cov-2 disease threatens health worldwide and significantly affects people's daily routine. in china, where the pandemic started, shopping malls and schools were closed for a while, and city entrances and exits were stopped for a while. although there are similar practices in excellence, as in many countries, measures such as curfew, nursery and school closure continue to be taken for under-20s and over-65s. . the coronavirus epidemic that affects our entire life is not fully known about the disease process, who is defined as the pandemic of the epidemic, the nearest contact is the greatest risk of transmission, and the loss of many lives during this process affects all individuals in the society negatively and increases the level of anxiety . it is a psychological reaction involving many emotions such as anxiety, stress, or anxiety, fear and distress that arise in a situation that threatens the safety of the individual. conditions such as uncertainty, various diseases (cancer, epidemic, etc.) and losing a relative can cause anxiety. outbreaks that occur suddenly and are at risk of death are among these reasons.

Eligibility criteria:
inclusion criteria; * individuals agree to participate in the study * 18 years old, * lack of visual obstacle, * knowing how to speak, read and write in turkish. exclusion criteria; * individuals refuse to participate in the study * 18 years old, * visually impaired, * does not know how to speak, read and write in turkish

Keywords: coronavirus anxiety scale covid-19 anxiety
clinical evaluation of the safety and efficacy of yung sheng 38% color contact lens

Conditions: Myopia

Summary: this was a single group, open-label clinical study to assess the safety and efficacy of yung sheng 38% color contact lens for vision correction.


Eligibility criteria:
inclusion criteria: 1. the subject must sign the informed consent form. 2. the subject must be at least 20 years of age as of the date of evaluation for the study. 3. the subject must have a spherical prescription range between 0 to -12.00 diopters in each eye. 4. the subject must have manifest refraction snellen visual acuities (va) less than 0.8 in each naked eye. 5. the subject must have normal eyes, except ametropia. 6. the subject must appear able and willing to adhere to the instructions set forth in this clinical protocol. 7. the subject must appear able and willing to fill the daily card. exclusion criteria: 1. the subjects who need to use ophthalmic medicine for therapy. 2. the subjects who have ocular or systemic allergies or disease that may interfere with contact lens wear. 3. the subjects who have any history of ocular surgery/injury within 8 weeks prior to enrollment. 4. the subjects who have clinically significant tear secretion abnormal. 5. the subjects who enrolled in another contact lens clinical trial within 30 days prior to enrolment.
use of the elad® in patients with liver failure to provide expanded access with cost recovery

Conditions: Liver Failure

Summary: vti had established other clinical protocols to study the effects of elad® plus standard therapy compared with standard therapy alone in patients with acute on chronic (aoch) (vti-201, vti-206) and fulminant hepatic failure (fhf) (vti-202) and acute alcoholic hepatitis (aah). however, liver failure (lf) patients who do not qualify for other protocols may benefit from elad use. in order to accommodate physician requests for the use of elad in lf patients who do not qualify for open protocols, without the need to resort to individual emergency use inds for each case, vti has developed a treatment protocol with cost recovery to provide for expanded access to elad for those with lf. this uncontrolled treatment protocol has been designed to provide expanded access to elad in subjects with lf while assuring that sufficient data are collected to adequately monitor elad safety when used in this setting at multiple centers in the united states.

elad® therapy is designed to provide continuous liver support to a subject with compromised liver function, allowing time for the subject's native liver to regenerate to a healthy state, or to stabilize the subject until a suitable donor organ can be found for transplantation.

Eligibility criteria:
inclusion criteria: 1. weight ≥15 kg; 2. age ≥10 and ≤70 years; 3. meld score of ≥24; 4. documented liver failure; 5. subject or designated representative must be willing to sign an informed consent form specific to this study and comply with study requirements. exclusion criteria: 1. cerebral perfusion pressure (cpp) as measured by an intracranial pressure (icp) monitor.: 1. patients ≥ 18 yrs of age with cerebral perfusion pressures ≤40 mm hg for one hour or longer. 2. patients ≤18 yrs with cpp ≤35 mm hg for one hour or longer. 2. concomitant disease including chronic congestive heart failure, vascular disease, emphysema, aids, cancer, acute fatty-liver disease, hepatitis due to herpes virus, wilson's disease, or budd-chiari syndrome; 3. portal hypertension; 4. liver dysfunction due to trauma; 5. hemorrhage or irreversible brain death; 6. platelet count \<50,000/mm3 or reducing to \<80,000/mm3 over a 72 hour period; 7. mean arterial pressures (map) ≤50 mm hg for one hour or longer as measured by an indwelling arterial line, or; patients ≤18 years old and whose map is ≤40 mm hg for one hour or longer; 8. vasopressor support exceeding 1.0 µg/kg/min of an alpha-adrenergic agent for one hour or longer; 9. clinical or radiographic evidence of stroke or intracerebral bleeding; 10. seizures uncontrolled by medication; 11. acute myocardial infarction based on clinical and/or electrocardiographic evidence; 12. lung disease defined by a pao2 ≤ 60mm hg or an fio2 ≥0.6; 13. pregnancy as determined by βhcg results; 14. ≤2 weeks postpartum; 15. eligible for an open elad clinical trial

Keywords: expanded access to elad® in patients with liver failure
variability of pentacam-derived back elevation measurements in keratoconus and cross-linked corneas

Conditions: Keratoconus

Summary: primary objective of this study was to assess the intrasession, intersession and interobserver variability of the pentacam-derived posterior corneal elevation measurements in keratoconus eyes and eyes that underwent corneal collagen cross-liknking (cxl) treatment due to progressive keratoconus.

the pentacam classic (oculus optikgerate gmbh, heidelberg, germany, software version 1.14r04) was used for the sake of the study.two study groups were formed: 1) keratoconus group (kc) included patients with progressive keratoconus and 2) collagen-cross-linking group (cxl) included keratoconus patients that had been treated with uneventful cxl at least on year prior to their enrollment in the study. three consecutive scans were obtained by two experienced operators. the same procedure was repeated within two weeks for the assessment of intersession variability. in all cases acceptable maps had at least 10.0mm of corneal coverage.all back elevation points were codified in order to facilitate statistical processing of data. further to single point analysis, three additional parameters were evaluated: a) zone 4 parameter (z4) which derived by the analysis of all points at the central 4.0mm diameter zone, b) zone 8 parameter (z8) which derived by the analysis of all points at the central 8.0mm diameter zone, and, c) highest elevation point parameter (hep), which derived by the analysis of the highest elevation points for all participants. reproducibility of measurements was evaluated by means of intraclass correlation coefficients (icc). three different icc types were calculated: a) intrasession icc for both operators (icc1 \& icc2), b) interobserver icc, and, c) intersession icc. moreover, bland-altman plots were used to evaluate the level of agreement between the two operators.

Eligibility criteria:
inclusion criteria: * progressive keratoconus (keratoconus group) * corneal collagen cross linking (cxl) treatment at least one year prior to enrollment (cxl group) exclusion criteria: * glaucoma * suspicion of glaucoma * history of herpetic keratitis * corneal scarring * severe eye dryness * pregnancy or nursing * current corneal infection * underlying autoimmune disease

Keywords: posterior corneal surface elevation pentacam-scheimpflung imaging variability progressive keratoconus corneal cross-linking