Kornimate/medical-research-clean huggingface dataset:
hair cycle modulation to promote human wound healing

Conditions: Wounds

Summary: chronic wounds represent a huge burden to both patients and the national health service (nhs), with over 200,000 sufferers in the uk alone. based on current conservative estimates the nhs spends £2.3 - £3.1 billion pounds every year treating these patients. this study aims to reduce this shared burden, preliminary data from our research group using animal models has demonstrated variable ability of hair follicles to heal wounds based upon their stage within their growth cycle. this currently proposed study therefore aims to perform a simple novel intervention on patients prior to their elective surgery in an effort to replicate the substantial healing abilities noted in the animal models. under normal circumstances, a patient's operative site is shaved prior to the surgery for hygiene and visual simplicity. the aim of this study is to wax 50% of the patient's operative site prior to their surgery, the other half will be shaved on the day of surgery as per normal surgical protocol. based on known data this waxing technique will cycle the hair follicles into their growth phase at the time of surgery. the growth phase of hair follicles corresponds with an increased ability to heal due to recruitment of a patients own stem cells. this study therefore aims to take advantage of the patient's own stem cell population. the 50% waxing and 50% shaving method upon each patients donor site allows us to directly compare the influence of these two methods directly on a patient-by-patient basis.


Eligibility criteria:
inclusion criteria: * patient is undergoing skin graft surgery * patient is 18 years of age or older. * written and informed consent provided. exclusion criteria: * participants that have been enrolled in a clinical trial within the last 3 months that would affect their ability to heal or influence hair cycle. * specific hair-linked diseases, e.g. alopecia areata. (not including androgenetic alopecia) * lack of capacity to consent * lymphedema * malnutrition * collagen disorders * patients requiring grafts smaller than 5cm x 5cm * patients requiring grafts wider than 10cm * immunomodulation drugs * patients will be excluded mid study if they develop an infection that prevents biopsy retrieval

Keywords: wound hair follicle
pharmacokinetics and pharmacodynamics of biphasic insulin aspart 30 in healthy volunteers

Conditions: Diabetes; Healthy

Summary: this trial is conducted in europe. the aim of this trial is to investigate the pharmacokinetics and pharmacodynamics of insulin x14 30/70 premix compared to human insulin 30/70 premix in healthy volunteers.


Eligibility criteria:
inclusion criteria: * non-smokers * bmi (body mass index) maximum 27 kg/m\^2 * hba1c (glycosylated haemoglobin a1c): 3.4-6.1% * fbg (fasting blood glucose) maximum 6.0 mmol/l
study to evaluate the safety, tolerability, and efficacy of asc41 in adults with nash

Conditions: Nonalcoholic Steatohepatitis (NASH)

Summary: this is a phase 2, randomized, double-blind, placebo controlled study in adults with biopsy confirmed nash. the study is aimed at evaluating efficacy and tolerability of asc41 in adults with nash.


Eligibility criteria:
key inclusion criteria: * presence of ≥ 8% liver fat content on screening mri-pdff. * histologic evidence of nash upon central read of a liver biopsy obtained no more than 6 months before day 1 defined by nash activity score (nas) greater than or equal to 4 with at least 1 point each in inflammation and ballooning. * diabetes mellitus well controlled based on laboratory test hba1c ≤ 9.5%. key exclusion criteria: * evidence of advanced liver disease such as cirrhosis (stage 4 fibrosis) or decompensated liver disease (e.g. ascites, esophageal varices) or liver cancer. * evidence of other causes of chronic liver disease. * weight change ≥ 5% after qualifying liver biopsy or mri-pdff performed. * any contraindications to a mri scan. * treatment with vitamin e (unless stable dose of \< 400 iu/d), thiazolidinediones (tzd), or glucagon-like peptide-1 receptor agonists (glp-1 ra), unless subject is on a stable dose for 6 months prior to qualifying liver biopsy. * known history of alcohol or other substance abuse within the last year or at any time during the study. * use of any investigational drug within 6 months of mri-pdff and/or liver biopsy. * known positivity for antibody to human immunodeficiency virus (hiv).

Keywords: nafld phase 2 thyroid hormone receptor agonist nash asc41
impact of basic needs assessment and support to improve colposcopy show rate

Conditions: Cervical Cancer

Summary: the investigators will perform a randomized controlled trial in which 72 eligible patients (low-income, uninsured, or on medicaid) who are referred for colposcopy at washington university school of medicine, are enrolled and then screened for unmet social needs and distress. the participants will then be randomized 1:1 into either receive the social needs navigator program (n=36) or enhanced usual care (n=36).


Eligibility criteria:
inclusion criteria: * abnormal cervical cancer screen * missed appointment at bjh colposcopy clinic and need to reschedule * age 21 years or older * able to provide verbal consent * diagnosis of an abnormal cervical screen confirmed by cytology or pathology exclusion criteria: * individual without a cervix * known diagnosis or history of cancer * unable to consent

Keywords: colposcopy cervical cancer prevention adherence to follow-up unmet social needs distress
effects of dexmedetomidine on activity in the subthalamic nucleus

Conditions: Parkinson's Disease; Deep Brain Stimulation Surgery

Summary: the purpose of this research study is to find out whether dexmedetomidine changes brain cell activity in the subthalamic nucleus (stn).

in order to find whether dexmedetomidine is optimal for sedation during deep brain stimulation surgery, we will measure the electrical activity in the stn during deep brain stimulation surgery, and measure how this activity is changed during administration of dexmedetomidine. we hypothesize that dexmedetomidine does not change the firing rate and pattern in the stn.

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo bilateral stn electrode implantation surgery with micro-electrode recording for the treatment of parkinson's disease. exclusion criteria: * hypersensitivity to dexmedetomidine * bradycardia: sinus rhythm slower than 50 bpm * known or suspected obstructive sleep apnea * suspected difficult intubation * pregnancy * under 18 years of age or over 85 years of age * cognitive disability impairing understanding the experiment or signing the informed consent form

Keywords: subthalamic nucleus microelectrode recording deep brain stimulation electrode implantation
influence of soft tissue thickness on the bone level around implants

Conditions: Tooth Loss

Summary: healthy soft tissue around the implant are considered as a biological seal to prevent inflammatory periimplant diseases and ensure healthy, stable and long-term survival of a dental implant. due to the fact that the measurement methods in the literature differ, it is necessary to establish objective measurement method and to determine the minimum amount of tissue thickness to maintain a stable level of bone around the implant.

healthy soft tissue around the implant are considered as a biological seal to prevent inflammatory periimplant diseases and ensure healthy, stable and long-term survival of a dental implant. due to the fact that the measurement methods in the literature differ, it is necessary to establish objective measurement method and to determine the minimum amount of tissue thickness to maintain a stable level of bone around the implant. purpose: the aim of the study was to determine the effect of soft tissues in the implant area on the marginal bone level loss in the implant area and to define of the critical gingival thickness to minimize marginal bone level (mbl) loss. materials and methods: 75 bone level implants (conelog® camlog, switzerland) were inserted in the aesthetic area. thickening of soft tissues was performed both before and after implantation (group ii and iii), ctg and xcm were used (subgroup a and b). 12 months after the loading with final restoration, the thickness of soft tissues in the implant area was examined with ultrasonography (usg) device (pirop®, echoson, poland), and each implant was subjected to radiovisiography (rvg) rvg examination, where mbl loss was determined.

Eligibility criteria:
inclusion criteria: to qualify for the study, the patients had to be \>18 years and have missing teeth in the esthetic zone. additional inclusion criteria were as follows: * missing single or double teeth in the anterior area of their upper or lower jaw with a proper inter arch relationship (incisors, canines and first premolar) with a ridge width (bucco-lingual) greater than 5 mm at its narrowest point and a minimum keratinized gingiva height of 2 mm buccally. * no previous soft tissue augmentation procedure at experimental site exclusion criteria: the criteria that disqualified patients from the study were previous grafting procedures in the area of interest and systemic or local diseases that could compromise healing or osteointegration. smokers and patients with bruxism were also excluded from the study. additional exclusion criteria were as follows: * implants placed with an insertion torque of 35 ncm or less; * irradiation in the head and neck area; * untreated periodontitis; * poor oral hygiene (plaque score approximal plaque index (api) 20%, bleeding score 10%) and * poor motivation; * fresh post extraction sockets

Keywords: dental implants
prospective cohort study of patients intolerant to high pressure under continuous positive airway pressure treated with bilevel positive airway pressure as second-line therapy.

Conditions: Obstructive Sleep Apnea

Summary: prospective observational study of obstructive sleep apnea patients treated with bilevel positive airway pressure: aircurve 10 vautotm

to characterize, in routine practice, non compliant patient to continuous positive airway pressure who can get a benefit of a bilevel positive airway pressure therapy as a second line treatment (aircurve 10 vautotm ) to evaluate the clinical management of obstructive sleep apnea patients treated by aircurve 10 vautotm , especially impact on compliance and residual apnea hypopnea index. to evaluate aircurve 10 vautotm benefit on quality of life and quality of sleep

Eligibility criteria:
inclusion criteria: * adult patient * obstructive sleep apnea patient previously treated by continuous positive airway pressure non-compliant to therapy * patient naive of bilevel positive airway pressure therapy exclusion criteria: * bilevel positive airway pressure contraindication * severe respiratory disease diagnostic
a study to assess the safety of mavacamten in korean patients with symptomatic obstructive hypertrophic cardiomyopathy

Conditions: Obstructive Hypertrophic Cardiomyopathy

Summary: the purpose of this observational post-marketing surveillance study is to assess the real-world safety of mavacamten for the treatment of symptomatic obstructive hypertrophic cardiomyopathy (ohcm) in adult participants in korea. participants who will receive at least 1 dose of mavacamten will be enrolled.


Eligibility criteria:
inclusion criteria: * adult participants 19 years of age or older * participants who receive mavacamten according to the approved product label * participants who sign the informed consent form exclusion criteria: * participants who are prescribed mavacamten for therapeutic indications not approved in korea * participants for whom mavacamten is contraindicated as clarified in korean prescribing information approved by the ministry of food and drug safety
efficacy of paragastric neural block procedure on postoperative pain in patients who underwent sleeve gastrectomy

Conditions: Obesity; Post Operative Pain

Summary: surgical treatment is the most effective way to achieve effective and sustainable weight loss in patients with obesity and to improve the comorbidities caused by it. although minimally invasive bariatric surgical procedures are applied today, postoperative pain is one of the most basic problems. opioid-derived drugs used for pain control cause respiratory depression and constipation. enhanced recovery after surgery (eras) protocols recommend reducing opioid use after bariatric surgery to help patients have a healthier postoperative period. different methods such as transversus abdominis plane (tap) block and erector spinae plane (esp) block are used to reduce the postoperative opioid dose and for effective pain control. while these methods are effective in controlling somatic pain, they have no effect on visceral pain. it has been shown that patients' pain and opioid consumption decrease especially after celiac plexus block. vagal and sympathetic afferent stimuli from the gastrointestinal tract, on the other hand, stimulate the vomiting center and cause nausea and vomiting. paragastric neural block is a new method performed by injecting local anesthetic into the posterosuperior paragastric area in the area covering the left gastric artery by revealing the esophagogastric junction, proximal stomach, middle of the stomach, distal antrum, hepatoduodenal ligament and stomach posterior along the border of the lesser omentum. in this way, it is aimed to prevent both visceral pain and the symptoms of nausea and vomiting. in our study, the investigators aimed to evaluate the efficacy and safety of paragastric nerve block applied during laparoscopic sleeve gastrectomy by comparing it with the control group.


Eligibility criteria:
inclusion criteria: * body mass index of over 35 and an obesity-related comorbidity, * body mass index of over 40, * patients who underwent laparoscopic sleeve gastrectomy, * asa risk score of 2-3, * agreed to be included in the study. exclusion criteria: * chronic pain disorder or using gabapentin, * opioid addicts, * using anticoagulant drugs, * history of previous upper gastrointestinal system surgery, * surgical complications during or after surgery, * hepatic or renal failure, * moderate or severe cardiovascular or respiratory disease, * allergy to the local anesthetic agent to be applied for the block, * limited cooperation, * more than one surgical intervention in the same session, * allergy to the drugs to be used in the postoperative treatment protocol.

Keywords: obesity post operative pain pain block sleeve gastrectomy
efficacy and safety of ursodeoxycholic acid in reversing gastric intestinal metaplasia

Conditions: Gastric Intestinal Metaplasia

Summary: the goal of this clinical trial is to investigate the efficacy of ursodeoxycholic acid in treating gastric intestinal metaplasia in helicobacter pylori-negative adults. it will also learn about the safety of ursodeoxycholic acid. the main questions it aims to answer are: does ursodeoxycholic acid promote the regression of im in individuals without helicobacter pylori infection? what medical problems do participants experience when taking ursodeoxycholic acid? researchers will compare ursodeoxycholic acid to a placebo (a look-alike substance that contains no drug) to see if ursodeoxycholic acid is effective in treating gastric intestinal metaplasia. participants will: take ursodeoxycholic acid or a placebo every day for 6 months. visit the clinic once every 4 weeks for checkups and tests.


Eligibility criteria:
inclusion criteria: * patients aged from 18 to 75 years old. * patients with olgim stage ⅱ-ⅳ diagnosed by upper gastrointestinal endoscopy and histopathological examination within the last 3 months. * patients without helicobacter pylori infection, including patients who had successful helicobacter pylori eradication before enrollment. exclusion criteria: * a history of regular use (defined as at least once per week) of non-steroidal anti-inflammatory drugs (nsaids) and/or statins. * a history of stomach surgery (including endoscopic submucosal dissection and endoscopic mucosal resection) or previously diagnosed malignant tumor. * a history of heart failure, renal failure, liver cirrhosis or chronic hepatic failure; patients with contraindications or allergies to the drugs in this study. * breastfeeding or pregnancy. * a history of substance abuse or alcohol abuse within the past one year. * patients with severe mental illness. * refusal to undergo drug treatment. * refusal to sign informed consent.
rectovestibular fistula which surgical approaches?

Conditions: Vestibular Fistulae

Summary: this study was a prospective, randomized, comparative study that included female children with rectovestibular fistulae who were selected from patients with anorectal malformations treated at the pediatric surgical unit, assiut university hospital during the period from january 2016 to february 2020. the patients were randomly divided into four groups according to the procedure performed: trans- sphincter anorectoplasty(tsarp), posterior sagittal anorectoplasty, classic anterior sagittal anorectoplasty (asarp), and modified asarp.

background: the management of a vestibular fistula is a challenge for pediatric surgeons. the investigator compared four different operative techniques in terms of postoperative complications, continence, and cosmetic appearance. patients and methods: this study was a prospective, randomized, comparative study that included female children with rectovestibular fistulae who were selected from patients with anorectal malformations treated at the pediatric surgical unit, assiut university hospital during the period from january 2016 to february 2020. the patients were randomly divided into four groups according to the procedure performed: trans- sphincter anorectoplasty(tsarp), posterior sagittal anorectoplasty, classic anterior sagittal anorectoplasty (asarp), and modified asarp.

Eligibility criteria:
inclusion criteria: * female children aged 6 months to 12 years who had rectovestibular fistulae that had been treated by a single-stage repair were included in this study. exclusion criteria: * exclusion criteria were patients with recurrence, previous anorectal surgery. * patients with anovestibular fistulae. * patients with rectoperineal fistulas. * patients with cognitive impairment.

Keywords: vestibular anus, anal transposition, anorectal malformations transfistula anorectoplasty
anti-diabetic effect of gynostemma pentaphyllum tea as add-on therapy with sulfonylureas in type 2 diabetic patients

Conditions: Type 2 Diabetes

Summary: the present study aimed at investigating effect of gynostemma pentapyllum (gp) extract, administered as a "tea", as add-on therapy with sulfonylurea (su) in drug-naive patients with newly diagnosed type 2 diabetes. after screening, all patients received gliclazide mr 30mg and instruction regarding diet and physical exercise for 12 weeks. after 4 weeks treated with gliclazide mr 30mg, the patients was randomized to additional gp tea or placebo tea, 3 g twice daily during 8 weeks. oral glucose tolerance tests were performed at baseline, after 4 and 12 weeks. blood tests were taken with the purpose to monitor lipids, kidney and liver function.

in vietnam, herbal extracts have been used as a long-standing tradition to treat diabetic patients, but effects of these extracts have not been studied adequately. based on previous results in experimental animal, the investigators have selected the plant gynostemma pentapyllum (gp), which grows in the mountain region of northern vietnam. gp extract had a hypoglycemic effect on mice and rat. in addition, gp has been shown to reduce both hyperglycemia and hyperlipidemia in diabetic zucker fatty rats.the present study aimed at investigating effect of gynostemma pentapyllum (gp) extract, administered as a "tea", as add-on therapy with sulfonylurea (su) in drug-naive patients with newly diagnosed type 2 diabetes.in addition to monitoring effects plasma glucose regulation, the investigators also studied possible effects on plasma lipids, kidney and liver function as well as body weight and blood pressure.

Eligibility criteria:
inclusion criteria: * newly diagnosed, drug-naive patients with type 2 diabetes * fasting plasma glucose (fpg)9.0-14.0 mmol/l * hba1c 9-13% exclusion criteria: * type 1 diabetes * liver failure * kidney failure

Keywords: herbal medicine type 2 diabetes gynostemma pentaphyllum tea insulin sensitivity add-on
study to evaluate the role of itopride hci in patients with irritable bowel syndrome with predominant constipation

Conditions: Irritable Bowel Syndrome

Summary: patients suffering from irritable bowel syndrome with predominant constipation will be provided with the study medication. the study medication will be evaluated for its efficacy in relieving the symptoms


Eligibility criteria:
inclusion criteria: 1. male or female patient fulfilling the rome iii criteria for ibs-c 2. signed informed consent at screening visit exclusion criteria: 1. patients having significant diarrhea at least 25% of the time during the past 3 months 2. patients having alarm symptoms or signs 3. chronic diarrhea 4. history of gastrointestinal haemorrhage, mechanical obstruction or perforation 5. patient with clinically relevant ecg abnormalities (prolonged qt interval) 6. active psychiatric disorder that would interfere with the study objectives 7. health conditions (e.g. age related impairment of cognitive functions) that would interfere with the study objectives or might impair the compliance of the patient 8. severe hepatic, renal, cardiac, metabolic, haematological or malignant diseases (including prolactin dependent tumours) or clinically relevant deviations in laboratory values (ast/alt greater than twice the upper limit of normal, serum creatinine \* 2 mg/dl \[177 µmol/l\] according to the medical judgement of the investigator 9. patient with hypokalemia (serum potassium \< 3.5 mmol/l). 10. history of any known hypersensitivity to the ingredients of the investigational drug 11. pregnancy or lactation 12. women with childbearing potential who do not apply a medically accepted method of contraception.
experience of an emergency intensive care unit during covid-19 pandemic

Conditions: Covid19

Summary: covid-19, which emerged in china in december 2019, has become a pandemic with its spread to many countries of the world. emergency departments also carried out an important part of the fight against pandemics in our country/turkey. the emergency department including an intensive care unit is very few in this country/turkey and the only hospital, which has an emergency intensive care unit (eicu) in istanbul, is the study center. therefore, this retrospective study aimed to provide useful information about how an effective eicu should be, especially how to use them during pandemic periods.

covid-19, which emerged in china in december 2019, has become a pandemic with its spread to many countries of the world. emergency departments also carried out an important part of the fight against pandemics in our country/turkey. the emergency department including an intensive care unit is very few in this country/turkey and the only hospital, which has an emergency intensive care unit (eicu) in istanbul, is the study center. throughout the pandemic, many patients, including covid-19 patients, were successfully followed up and discharged from eicu. with this study, the investigators expect to show the role of eicu during the pandemic. in addition, it will be seen that whether the patients, who are waiting for hospitalization or waiting for referral, are admitted to eicu faster and their treatments will be started promptly. therefore, this retrospective study aimed to provide useful information about how an effective eicu should be, especially how to use them during pandemic periods.

Eligibility criteria:
inclusion criteria: * all patients who followed up in emergency department icu with the diagnosis of covid-19 * accepted to participate with an informed consent exclusion criteria: * patients under the age of 18 or more than 50 years * declined to participate * deaths caused by other than covid-19