Kornimate/medical-research-clean huggingface dataset:
the acute effect of physical exercise in pregnancy

Conditions: Pregnancy Related

Summary: the goal of this crossover clinical trial is to investigate the acute physiological effect of exercise on the uterine and fetal blood flow in pregnancy. the main questions it aims to answer are: * what is the acute physiological effect of exercise on the uterine and fetal blood flow in pregnancy? * what is the acute physiological effect of continuous aerobic exercise versus resistance exercise on the uterine and fetal blood flow in pregnancy? * what is the effect of physical activity levels on the uterine and fetal blood flow in pregnancy? researchers will compare the continuous aerobic exercise to the resistance exercise with a 3-6-week interval to examine the acute physiological effect on the uterine and fetal blood flow. participants will: * fill in a physical activity level questionnaire at baseline. * complete either continuous aerobic exercise or resistance exercise and take blood flow measurements. * complete the remaining type of exercise after a 3-6-week interval and take blood flow measurements.


Eligibility criteria:
inclusion criteria: * pregnant, over the age of 18 years, singleton pregnancy, both primigravidas and multigravidas, uncomplicated pregnancy and absence of contra-indications for exercise as per canadian guidelines (mottola et al. 2018). exclusion criteria: * smoking, substance abuse, chronic diseases, fetal growth restriction, fetal abnormalities, hypertension, history of premature delivery, vaginal hemorrhage, placenta previa, contractions before/during intervention, diabetes mellitus, preeclampsia and previous pregnancy complications.

Keywords: blood flow pregnancy aerobic exercise resistance exercise doppler ultrasound physical activity
comparison of single port and two ports robotic assisted thoracic surgery for thymectomy

Conditions: Thymoma; Myasthenia Gravis Associated With Thymoma; Thymectomy

Summary: recently, robotic-assisted thoracic surgery (rats) has become into as an alternative approach to either, open surgery or video-assisted thoracoscopic surgery. the superiorities of rats have been reported in series studies, such as intuitive movements, tremor filtration, more degrees of manipulative freedom, motion scaling, and high-definition stereoscopic vision. however, the currently reported robotic thymectomy used 3 ports. theoretically, less incisions may bring faster postoperative recovery, lighter postoperative pain and higher postoperative quality of life. the investigators have successfully performed robotic thymectomy through 2 ports and even 1 port. however, the potential benefit of less ports robotic thymectomy has not been verified through well-designed cohort study, so this clinical trial has been designed.

the gold standard technique for thymectomy used to be transsternal approach. advancements in modern technology bring many evolutions in minimally invasive surgery such as video-assisted thoracic surgery (vats) thymectomy gained popularity after 2000s. recently, robotic-assisted thoracic surgery (rats) has become into as an alternative approach to either, open surgery or video-assisted thoracoscopic surgery. the superiorities of rats have been reported in series studies, such as intuitive movements, tremor filtration, more degrees of manipulative freedom, motion scaling, and high-definition stereoscopic vision. however, the currently reported robotic thymectomy used 3 ports. theoretically, less incisions may bring faster postoperative recovery, lighter postoperative pain and higher postoperative quality of life. the investigators have successfully performed robotic thymectomy through 2 ports and even 1 port. however, the potential benefit of less ports robotic thymectomy has not been verified through well-designed cohort study, so this clinical trial has been designed.

Eligibility criteria:
inclusion criteria: 1. patients with myasthenia gravis and(or) thymoma need to perform thymectomy. 2. agree to accept robotic assisted thoracic surgery and have signed informed consent. exclusion criteria: 1. cardiopulmonary function cannot tolerate thoracoscopic surgery or exist other contraindication. 2. thymic carcinoma. 3. thoracic deformity.

Keywords: thymoma myasthenia gravis thymectomy robotic assisted thoracic surgery
immunoadsorption vs. plasmapheresis in the escalation therapy of relapse in multiple sclerosis

Conditions: Multiple Sclerosis; Clinically Isolated Syndrome

Summary: this observational study investigates the efficacy and safety of immunoadsorption versus plasmapheresis in 60 patients with relapse in multiple sclerosis and clinically isolated syndrome who do not fully recover after a high doses of intravenous corticosteroids.


Eligibility criteria:
inclusion criteria: * relapse of multiple sclerosis or clinically isolated syndrome (without complete remission after high dose steroid therapy) * informed consent * age ≥ 12 years old exclusion criteria: * clinical or laboratory signs of infection * intake of angiotensin converting enzyme inhibitor within 1 week prior to first treatment

Keywords: immunoadsorption plasmapheresis
acute effects of amps on cardiovascular, functional capacity and postural control in patients with parkinson's disease

Conditions: Parkinson Disease

Summary: considering that parkinson's disease (pd) can significantly compromise functional mobility and cardiovascular system in patients with pd, therapies aimed at improving these aspects, mainly by non-pharmacological and non-invasive methods, are paramount. this clinical trial will study the acute effects of plantar stimulation using a therapy called automated peripheral mechanical stimulation (amps) on cardiovascular and functional mobility in patients with pd. the hypothesis of this study is that one single session will be effective in improving, acutely, the cardiovascular system and functional capacity in patients with pd.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of idiopathic parkinson's disease * scoring 1 to 3 on the hoehn and yhar scale * pharmacological treatment unchanged for at least 30 days prior the study exclusion criteria: * signs of cognitive decline, based on the results of the mini mental state examination * cardiorespiratory, neuromuscular and musculoskeletal diseases not related to pd * sensory peripheral neuropathy, diabetes or any other disease known to promote autonomic dysfunction
myocardial work and metabolism in crt

Conditions: Left Ventricular Dyssynchrony; Heart Failure; Left Bundle Branch Block; Cardiomyopathy

Summary: several attempts have been made to refine selection criteria for cardiac resynchronisation therapy (crt) in heart failure patients with reduced ejection fraction (hfref). previously proposed parameters probably do not sufficiently reflect the underlying mechanical dyssynchrony of the left ventricle (lv). earlier work of our research group suggests that better candidate selection can rely on the direct observation or measurement of this lv mechanical dyssynchrony by means of non-invasive imaging. in this study apical rocking and other non-invasive measures of lv mechanical dyssynchrony will be applied to evaluate regional myocardial workload and metabolism, and determine their predictive value in crt response.


Eligibility criteria:
inclusion criteria subject is eligible for crt implantation according to current european society of cardiology guidelines of 2013. * the patient should receive guideline-directed optimal medical therapy for heart failure and left ventricular (lv) function must be severely depressed (lv ejection fraction ≤35%). * the patients should be in nyha functional class ii, iii or ambulatory iv. * the patient should present a left bundle branch block (lbbb) with qrs duration of \>120ms or a non-lbbb with qrs \>150ms. * also patients with conventional pacemaker in nyha functional class iii and ambulatory iv if high percentage of ventricular pacing, are eligible for crt implantation. * subject is in stable sinus rhythm at the time of crt implant and during the last 2 weeks prior to inclusion. * subject is 18 years or older and able and willing to consent. exclusion criteria: * impossible to obtain lv volumes by echocardiography. * right bundle branch block. * permanent atrial fibrillation, flutter or tachycardia (\>100 bpm). * recent myocardial infarction, within 40 days prior to enrolment. * subject underwent coronary artery bypass graft (cabg) or valve surgery, within 90 days. * post heart transplantation, or is actively listed on the transplantation list, or has reasonable probability (per investigator's discretion) of undergoing transplantation in the next year. * implanted with a lv assist device (lvad), or has reasonable probability (per investigator's discretion) of receiving a lvad in the next year. * severe aortic stenosis (with a valve area of \<1.0 cm2 or significant valve disease expected to be operated on within study period). * complex and uncorrected congenital heart disease. * breastfeeding women, women of child bearing potential. * enrolled in one or more concurrent studies that would confound the results of this study.

Keywords: cardiac resynchronisation therapy heart failure left ventricular dyssynchrony echocardiography apical rocking septal flash
water-based liuzijue exercise on childhood-onset systemic lupus erythematosus

Conditions: Systemic Lupus Erthematosus

Summary: systemic lupus erythematosus (sle) is a life-long systemic autoimmune disease with a large variability in its clinical course. the onset of sle during childhood and adolescence represents 10 to 20% of all sle cases \[1\] and is associated with a more severe disease course compared to adult sle. due to earlier diagnosis as well as significant advances in the management of childhood-onset sle (c-sle), mortality rates have greatly decreased, with an estimated 5- to 10-year survival rate of over 85% \[2\].as a consequence, there has been a great increase in long-term co-morbidities, particularly cardiovascular disease (cvd), which is currently considered a major cause of long-term mortality in c-sle patients \[3\].

systemic lupus erythematosus (sle) is a life-long systemic autoimmune disease with a large variability in its clinical course. the onset of sle during childhood and adolescence represents 10 to 20% of all sle cases as a consequence, there has been a great increase in long-term co-morbidities, particularly cardiovascular disease (cvd), which is currently considered a major cause of long-term mortality in c-sle patients. liuzijue, which is one such traditional chinese health exercise, is performed in expiration to produce six different sounds (xu, he, hu, si, chui, and xi) together with smooth movements of the upper and lower limbs .

Eligibility criteria:
inclusion criteria: * age between 7 and 15 years * systemic lupus erythematosus disease activity index (sledai)-2k score ≤ 16 exclusion criteria: * neuropsychiatry involvement, hematologic abnormalitie * cardiovascular rhythm and conduction disorders, musculoskeletal distur- bances that precluded participation in physical exercise * pleuritis, pericarditis, endocarditis, acute kidney failure

Keywords: systemic lupus erythematosus water-based exercise
evaluation of patient reported outcomes in rrms patients candidates for ms therapy change and transitioned to fingolimod 0.5 mg (epoc)

Conditions: Relapsing Remitting Multiple Sclerosis

Summary: a 6-month, randomized, active comparator, open-label, multi-center study to evaluate patient outcomes, safety and tolerability of (fingolimod) 0.5 mg/day in patients with relapsing remitting multiple sclerosis who are candidates for ms therapy change from previous disease modifying therapy.


Eligibility criteria:
inclusion criteria: * written informed consent must be obtained before any assessment is performed. * patients must be diagnosed with relapsing remitting ms (rrms) as defined by 2005 revised mcdonald criteria (mcdonald et al 2001, polman et al 2005) (appendix 2). * patients who explicitly agree to be assigned to a treatment group that may receive or dmt after having been informed about their respective benefits and possible adverse events by the investigator. * male or female patients aged 18-70 years. * an expanded disability status scale (edss) score of 0-6 inclusive. * must have received continuous treatment with a single approved and indicated ms dmt for a minimum of 6 months prior to the screening visit. patients must continue with this ms dmt until the randomization visit. * naïve to treatment with fingolimod. exclusion criteria: * a manifestation of ms other than those defined in the inclusion criteria. * a history of chronic disease of the immune system other than ms or a known immunodeficiency syndrome. * history of malignancy of any organ system. * diagnosis of macular edema during screening phase. * patients with active systemic bacterial, viral or fungal infections, or known to have aids or to have positive hiv antibody test. * patients who have received any live or live attenuated vaccines (including for varicella-zoster virus or measles) within 2 months prior to baseline. * patients who have received total lymphoid irradiation or bone marrow transplantation. * history of selected immune system treatments and/or medications. * any medically unstable condition, as assessed by the investigator. * selected cardiovascular, or hepatic conditions * selected abnormal laboratory values. * patients with any other disease or clinical condition (including neurologic or psychiatric disorders) which may affect patient enrollment into the study and study medication use by the investigators' opinion. * participation in any clinical research study evaluating another not approved in russia investigational drug or therapy within 6 months prior to baseline. * history of hypersensitivity to the study drug or to drugs of similar chemical classes. * pregnant or nursing (lactating) women. other protocol-defined inclusion/exclusion criteria may apply

Keywords: relapsing remitting multiple sclerosis (rrms) fingolimod disease modifying therapy (dmt) tsqm-9
wavefront-guided vs. topography-guided lasik

Conditions: Myopia

Summary: the study is comparing outcomes of wavefront-guided lasik to topography-guided lasik in a randomized contralateral fellow eye study in myopic participants.

the purpose of the study is to compare the results of wavefront-guided lasik surgery to topography-guided lasik surgery in participants with nearsightedness with or without astigmatism three fda-approved laser devices are being used for the study. two excimer lasers are being used for the study. the excimer laser is used to perform the reshaping of the cornea under a lasik flap to correct nearsightedness, farsightedness and astigmatism. the two lasers being utilized are the johnson and johnson visx customvue excimer laser and the alcon allegretto laser in the study. both have received fda-approval via a pma pathway. one femtosecond laser is being used in the study. the femtosecond laser is used to create the lasik flap during the first part of the lasik procedure. the intralase ifs150 femtosecond laser is being used in the study. the femtosecond laser received fda- approval via a 510k pathway. all three lasers are being used according to their approved indications.

Eligibility criteria:
inclusion criteria. * subjects ages 22 to 59with healthy eyes. nearsightedness between -1.00 diopters and -9.00 diopters. * subjects with less than or equal to 3.00 diopters of astigmatism. exclusion criteria. * subjects under the age of 22 and over the age of 59 * subjects with excessively thin corneas. * subjects with topographic evidence of keratoconus. * subjects with ectactic eye disorders. * subjects with autoimmune diseases. * subjects who are pregnant or nursing. * subjects must have similar levels of nearsightedness in each eye. they cannot be more than 1.5 diopter of difference between eyes. * subjects with more than 3.00 diopters of astigmatism * subjects must have similar levels of astigmatism in each eye. they cannot have more than 1.00 diopters of difference between eyes.

Keywords: wavefront-guided topography-guided lasik
does static ultrasound-preview reduce the incidence of difficult lumbar puncture?

Conditions: Headache; Meningitis; Subarachnoid Hemorrhage

Summary: does the use of ultrasound facilitate a lumbar puncture by reducing the number of difficult and traumatic lumbar punctures?

this is a controlled trial randomizing lumbar puncture patients to groups utilizing ultrasound to preview the bony structures of the spine versus using standard palpation technique. the goal is to determine the helpfulness of ultrasound in performing lumbar punctures (to reduce difficult and traumatic lumbar punctures) among patients whose spines cannot be easily visualized.

Eligibility criteria:
inclusion criteria: * age greater than 18 * clinical need for lumbar puncture * unable to visualize spine in position for the lumbar puncture exclusion criteria: * able to visualize the spinous processes

Keywords: lumbar puncture headache traumatic tap
impact of atrial fibrosis surface area on the occurrence of atrial fibrillation in patients with ischemic stroke of undetermined origin: a prospective cardiac mri pilot study.

Conditions: Stroke; Implantation of an Implantable Cardiac Monitor

Summary: atrial fibrillation is a cardiac arrhythmia most often originating in the left atrium, causing anarchic electrical activity and thus a loss of atrial contraction. this increases the risk of stroke through clot formation in the atrium, but also of heart failure. atrial fibrillation is a major cause of stroke, accounting for more than 25% of all strokes. in addition, a quarter of ischemic strokes remain without an obvious cause at the end of hospitalization, and it is recommended that atrial fibrillation be detected intensively with long-term heart rhythm recording. implantable loop recorders can detect 30% of atrial fibrillation cases over the 3-year battery life of these devices, after a stroke of undetermined origin. however, these devices require a small operation to implant them under the skin, and they are expensive. the hypothesis of this study is that mri imaging of the left atrium would enable better selection of patients to receive an implantable loop recorder. mri can quantify the proportion of the left atrium with scar tissue, which is likely to favour the onset of atrial fibrillation. if the results confirm this hypothesis, the number of patients requiring an implantable loop recorder could be reduced, and perhaps an anticoagulation strategy based on mri data could be introduced. in addition to the usual follow-up by cardiologists and neurologists, participation in this study involves a cardiac mri (with contrast agent) within 3 months of the stroke.


Eligibility criteria:
inclusion criteria: * patient who has provided free, written and informed consent * patient of legal age * patient with cryptogenic ischemic stroke within 30 days of inclusion, documented by brain imaging (cerebral angioscan or cerebral mri) * patients scheduled for implantable loop recorder implantation within 3 months of ischemic stroke in search of silent af: * cryptogenic ischemic stroke or stroke with probable cardioembolic cause * no history of atrial fibrillation * no long-term anticoagulant therapy * with life expectancy \>12 months exclusion criteria: * person not affiliated to national health insurance * person under legal protection (curatorship, guardianship) * person under court order * pregnant, parturient or breast-feeding * adult unable to give consent * patient diagnosed with af during stroke assessment * patient with a contraindication to mri or gadolinium injection: * severe renal impairment (\<30ml/min cockroft clearance due to gadolinium injection) * claustrophobia / contraindication to mri (metal implant not mri compatible) * history of hypersensitivity to gadoteric acid or gadolinium-based contrast agents, and to meglumine * uncontrolled asthma
team-red, a remotely delivered self-management program for depressed black women at risk for hypertension

Conditions: Depression

Summary: the proposed project is a 24-week prospective randomized controlled trial (rct) evaluating the effects of targeted management intervention (team, n=41) vs. enhanced waitlist (ewl, n=41) control in young (\<50 years) african american women who are depressed or suffering from stress, and at risk for hypertension.


Eligibility criteria:
phase 1 inclusion criteria: 1. registered on research goes red; 2. self-identified african american female ages 18-49; 3. current depression as measured by a score of ≥10 on the 9-item patient health questionnaire (phq-9), 4. have at least one of the following self or chart-recorded htn risk factors: body mass index (bmi) greater ≥ 30, hba1c \>5.75, at least one outpatient reading of systolic blood pressure (bp) ≥ 130 mm hg or diastolic ≥90 mmhg, current smoker, or ldl ≥100 mg/dl in the last 12 months; 5. are able to participate in study procedures. phase 1 exclusion criteria: 1. unwilling/unable to provide informed consent; 2. pregnancy; 3. imminent suicide risk, 4. a current diagnosis of hypertension or use of antihypertensive medications. phase 2 inclusion criteria 1. self-identified aa female ages 18-49; 2. endorses either: a past or current history of depression, current depression as measured by a score of at least a 5 on the 9-item patient health questionnaire (phq-9), or indicate feelings of stress or discrimination that impact their functioning 3. have at least one of the following self or chart-recorded htn risk factors: bmi greater ≥ 30,26 hba1c \>5.75,27 at least one outpatient reading of systolic bp ≥ 130 mm hg or diastolic ≥90 mmhg, current smoker, or ldl ≥100 mg/dl in the last 12 months; 4. are able to participate in study procedures. phase 2 exclusion criteria 1. unwilling/unable to provide informed consent; 2. pregnancy; 3. imminent suicide risk, 4. a current diagnosis of htn or use of antihypertensive medications.
evaluation of the advantage in the use of enteral nutrition in children treated for acute lymphoblastic leukemia

Conditions: Leukemia, Lymphoblastic

Summary: this is a multicenter retrospective study (reims and nancy), with data collection over 12 years from 01/01/2010 to 12/31/2022 patients included are children diagnosed with acute lymphoblastic leukemia between 2010 and 2021 in the 2 centers. patients will be categorized into 3 groups: * no nutritional support * support by enteral nutrition * parenteral nutrition support their nutritional status will be assessed at the end of induction, at 6 months and then at 12 months from diagnosis. the main objective of this study is therefore to compare the nutritional status of children with acute lymphoblastic leukemia depending on whether they received enteral or parenteral nutritional support during their treatment. the secondary objective is to evaluate the occurrence of complications during treatment according to the nutritional support received.


Eligibility criteria:
inclusion criteria: * children between 1 and 18 years old diagnosed with medium risk/ high risk b acute lymphoblastic leukemia or standard/ high risk t acute lymphoblastic leukemia between 2010 and 2021 in nancy and reims. exclusion criteria: * patients less than 1 year old * leukémia with philadelphia chromosome * standard risk b acute lymphoblastic leukemia * bone marrow transplant during treatment * death during the year following diagnosis * refusal of the patient (parents) to participate in the study