Kornimate/medical-research-clean huggingface dataset:
pulmonary hypertension in haemodialysis patients :frequency and risk factors

Conditions: Pulmonary Hypertension

Summary: high mortality rates due to cardiovascular disease in end-stage renal disease patients been described by epidemiological and clinical studies. it accounts for approximately 50 percent of deaths in dialysis patients. although controversial, this may be due to the presence of excess vascular calcification particularly in the form of extensive coronary artery calcification which can be observed even in very young dialysis patients. it was suggested that abnormalities of the right ventricular function in patients with end-stage renal disease were largely due to pulmonary hypertension which usually develops secondary to pulmonary artery calcifications.

primary whose mechanisms are incompletely known, is another vascular disease entity recently described in chronic kidney disease particularly in patients undergoing haemodialysis. it corresponds to 5th subtype of world symposium on pulmonary hypertension classification established in 2008 in dana point and updated in 2013 in nice. pulmonary hypertension is defined by pulmonary arterial pressure mean ≥25 mm hg at rest measured by right heart catheterization. its pathophysiological mechanism is controversy maybe explained by vascular calcification, blood flow in arteriovenous fistula and fluid overload. primary pulmonary hypertension is a major problem of haemodialysis patients because of its high prevalence, sometimes reaching 68% and by its significant morbidity and mortality.

Eligibility criteria:
inclusion criteria: * 80 haemodialsis patients aged from 18 to 60 years old * 80 haemodialysis patients are on regular haemodialysis for more than one year exclusion criteria: * all patients with a high probability of secondary pulmonary hypertension, those with the following history: chronic obstructive pulmonary disease, pulmonary embolism congenital heart disease, heart failure, bilharziasis plus active hiv infection.

Keywords: cardiovascular complications
task oriented activities based on ndt therapy principles

Conditions: Cerebral Palsy

Summary: cerebral palsy (cp) is one of the primary causes of disability effecting majority of pediatric population. cerebral palsy is considered a neurological disorder caused by a non-progressive brain injury or malformation that occurs while the child's brain is under development. the worldwide incidence of cerebral palsy is it affects three to four individuals out of 1000 individuals in the general population. cerebral palsy has different types depending upon the severity of disease or the area of the body it is affecting. amongst the different types of cp, spastic diplegia is the most common type which mainly affects the lower extremities and lesser extent to upper extremities. it mainly affects functional performance and gait.

this study will be conducted on 20 subjects which would be equally divided into experimental and control groups. trunk control measurement scale (tcms) and quality of upper extremity skills test (quest) will be the tools used in this study. pre and post values of the effects of intervention will be evaluated. the significance of this study is that it will help us how to improve trunk control and upper extremity function in spastic dipegic children. data will be analyzed using spss 22.0. mean and standard deviation will be calculated. appropriate statistical test will be used after checking normality of data.

Eligibility criteria:
inclusion criteria: * • children with spastic diplegic cerebral palsy with age between 6 to 12 years. * children with spastic diplegic cerebral palsy who are able to follow verbal commands. * children with spastic diplegic cerebral palsy having level ii or iii of gross motor function classification system. exclusion criteria: * • children who are uncooperative and having neurological deficit. * children with hearing deficit. * children with epilepsy. * children with cardiac anomalies which effect exercise tolerance. * children having less than 6-month post-orthopedic surgery. * children having less than 6-month post-botulinum toxin injection (botox).

Keywords: cp, ndt therapy, task-oriented training, trunk control
kinect sensor in cerebral palsy children: phase 2.1

Conditions: Cerebral Palsy Children; Upper Extremity Problem

Summary: there are 3 phases of the study. this registration is phase 2.1.this registration will conduct a pilot study in the cerebral palsy children.


Eligibility criteria:
inclusion criteria: * spastic cerebral palsy aged 10-15 years * sufficient cognitive/attention capacity to understand basic instructions * can cooperate with the therapist for short period of time during training * manual ability classification system (macs) 2-3 * zancolli classification of the affected upper extremity was grade i-ii. * give the informed consent exclusion criteria: * inability to understand the instruction and follow the task * severe comorbidities, visual or auditory impairment * had history of botulinum toxin injection on the affected upper extremity for last 6 months or receive the injection during the study time * other treatment options planned on the affected upper extremity during the study time * wear daytime orthosis on the affected limb * zancolli classification of the affected hand was grade iii. * got an epilepsy or convulsive condition * denied to give the informed consent or continue the study

Keywords: video-game kinect sensor upper extremities problems cerebral palsy children
pathos study pain assessment in thoracic oncologic surgery

Conditions: Pain, Postoperative; Lung Neoplasm

Summary: a randomized prospective trial to assess whether the use of loco regional anesthesia as adjuvant analgesic therapy is more effective of intravenous analgesia only.

a prospective randomized trial comparing intravenous analgesia alone and in association with loco regional anesthesia consisting in a homolateral serratus plan block (spb). loco regional blockade of the serratus is further examined by allocating the patients to two different approaches: the block being performed under us guidance by the anesthesiologist before the beginning of the procedure, or under direct visualization, by the operating surgeon, before entering the pleural cavity.

Eligibility criteria:
inclusion criteria: * lobectomy/ segmentectomy plus lymphadenectomy (systematic or sampling) for cancer (not necessarily nsclc) performed with a standardized, three portal minimally invasive approach. exclusion criteria: * patients who are pregnant or lactating * morbid obesity (bmi \> 35 ) * inability to understand and sign the informed consent * proven allergy to local anesthetic drugs as required by this protocol * patients under chronic analgesics or neuroleptic therapy for any reason and/ or with baseline pain score (nrs scale) of 3 or more.

Keywords: serratus block, pain management, lung lobectomy
ramadan fasting in patients with corticotrope deficiency treated either by hydrocortisone or by prednisolone

Conditions: Corticotropin Deficiency; Fasting

Summary: selected patients will be randomised to either hydrocortisone or prednisolone. each treatment period is of 14 days. abnormal clinical symptoms, blood glucose and quality of life will be monitored.

* selection of the patients who meet the inclusion and non inclusion criteria. * detailed explanations about the study to the patients. * signature of the informed consent by the patients. * randomisation of the patients by drawing lots into two groups; group ab who will receive treatment a during 14 days (period 1) then treatment b during 14 days (period 2) and group ba who will receive treatment b during 14 days (period 1) then treatment a during 14 days (period 2). * each patient will receive a daily follow-up sheet, a quality of life questionnaire, a glucometer with test strips and the treatment in different bottles for each period of the study. * the daily follow-up sheet concerns habits during ramadan (eating, sleeping), the occurrence of complications and blood glucose monitoring. daily blood glucose monitoring is requested at midday, before dinner and if a malaise occurs. a detailed questionnaire on abnormal symptoms that might occur during fasting have to be fulfilled for each malaise. * quality of life will be evaluated using addiqol questionnaire translated in tunisian dialect. patients have to complete the questionnaire before the fasting month and at the end of each period of treatment. * treatment is presented in the form of capsules with the same colour and size. patients have to take one capsule at dinner and one capsule at pre-dawn meal. patients will receive either hydrocortisone 15mg at pre-dawn meal and 5mg at dinner (sunset) (treatment a) or prednisolone 5mg at pre-dawn meal and a placebo (starch) at dinner (treatment b). * during the study, patients will be in regular phone contact with a responsible of the study for any information or problem. * at the end of the study, the completed follow-up sheets and questionnaires will be picked up.

Eligibility criteria:
inclusion criteria: * known corticotrope deficiency treated by 20mg hydrocortisone per day. * age: 18-70 years * patients who are willing to fast ramadan 2018 and who voluntary accept to participate in the study. non inclusion criteria: patients with either diabetes mellitus, hypertension, diabetes insipidus, severe organ damage (renal, cardiac, pulmonary, hepatic), neoplasia, psychiatric disease, epilepsy or pregnant or breast-feeding women. exclusion criteria: the occurrence of any of the non inclusion criteria during the study. the occurrence of a severe malaise.

Keywords: treatment quality of life hypoglycemia
coct versus lc-oct for diagnosing basal cell carcinoma: a diagnostic cohort study

Conditions: Basal Cell Carcinoma

Summary: basal cell carcinoma (bcc) is the most common form of cancer among the caucasian population. equivocal bcc lesions are usually diagnosed by means of a punch biopsy, but since the last few decades, non-invasive imaging techniques for the diagnosis of bcc gained popularity within the field of dermatology. conventional optical coherence tomography (coct) is an example of a non-invasive imaging technique. recent studies revealed that oct assessors may achieve high diagnostic certainty and accuracy for diagnosing bcc. however, coct has a limited axial and lateral resolution and can therefore only visualize the gross architecture of the skin. it has been proposed that the diagnostic certainty and accuracy of coct could be optimized by improving the resolution. line-field confocal optical coherence tomography (lc-oct) is a new non-invasive imaging technique that provides tridimensional images of the skin with a cellular resolution. although the resolution of lc-oct is superior to coct, the penetration depth of lc-oct (500µm) is limited compared to that of coct (1.0-1.5mm). in the proposed study, we aim to assess whether lc-oct is superior to coct in terms of diagnostic accuracy for diagnosing bcc in equivocal bcc lesions.


Eligibility criteria:
inclusion criteria: * patients (18+) with equivocal bcc lesions undergoing biopsy conform regular care exclusion criteria: * patients unable to sign informed consent * patients with clinically evident bcc lesions who do not undergo biopsy

Keywords: optical coherence tomography line-field confocal optical coherence tomography
chronic illness care management (cicm) study in primary care

Conditions: Chronic Illness; Quality of Life

Summary: the purpose of the study is to determine whether the quality of life of patients with multiple chronic conditions cared for by primary care physicians will improve due to the introduction of a chronic illness management intervention.

there is international recognition for the need of introducing improvement in chronic illness care. however, primary care physicians face a host of challenges for providing the best possible care to their patients. one of these problems is the lack of proper administrative systems. there is evidence indicating that tailored out reach facilitation is an effective means to improve practice performance. traditionally, the approach to care for chronically ill patients revolved mostly around the treatment of a specific chronic condition in an ad hoc basis. it is more common in family medicine for the patient to have several chronic conditions. there is also evidence showing that better health outcomes are obtained when the patients' life circumstances, desires and expectations are taken into consideration. various models of chronic illness care have emerged that are patient center while attempting to be comprehensive. our approach, following the australian model, seeks to introduce systems/administrative innovations at the practice level, intended also to increase the involvement of patients with multiple chronic conditions on its own care, throw tailored out reach facilitation and care planning tools for physicians, in order to improve chronic illness management in primary care settings.

Eligibility criteria:
inclusion criteria: * patient should suffer from any two or more chronic illnesses * patient should have been seen in the gp's office at least six to seven times in the previous year * patient should be 50 years of age or older exclusion criteria: * suffering from dementia or a major psychiatric condition, being terminally ill, not being competent to give informed consent for participating in the study, or the doctors considers that the patient will not benefit from the intervention.

Keywords: chronic disease quality of life
a prospective cohort study of perioperative covert stroke and postoperative cognitive dysfunction

Conditions: Anesthesia; Covert Stroke

Summary: with the development of population aging, the incidence of covert stroke gradually increased. currently, there is still lack of prospective cohort study with large sample size on the relationship between perioperative covert stroke and postoperative cognitive outcomes. the investigators will perform a prospective cohort study. the aim of the study is to determine whether there is an association between perioperative covert stroke and postoperative cognitive outcomes in elderly patients undergoing noncardiac surgery.


Eligibility criteria:
inclusion criteria: * eligible patients were aged ≥60 years and scheduled for elective non-cardiac surgery with general anesthesia, with or without concomitant regional analgesia. they were expected to have surgery lasting at least 2 hours of anesthesia and to stay in the hospital at least 2 days thereafter. exclusion criteria: * patients have mri contraindications, cannot complete the cognitive evaluation, undergo carotid artery surgery or refuse to sign informed consent will be excluded from the trial.
the effect of virtual reality applications

Conditions: Thyroid Cancer; Virtual Reality Therapy; Ultrasound; Fine Needle Aspiration Biopsy; Thyroid Nodule (Diagnosis)

Summary: thyroid nodules are a common health problem in the adult population. the majority of cancers are diagnosed by thyroid fine needle aspiration biopsy. thyroid nodules generally show clinical findings in 1-5% of cases on physical examination and 20-70% on ultrasound examination. in diagnosis; ultrasonography, fine needle aspiration biopsy, ultrasonography-guided fine needle aspiration biopsy, scintigraphy, computed tomography and magnetic resonance imaging are widely used. the fact that the thyroid fine needle aspiration biopsy procedure is painful, there is no speaking or coughing during the procedure, and in case of insufficient sample, the procedure must be performed several times. its repetition causes fear and anxiety in patients. a combination of pharmacological and nonpharmacological methods for pain control likely provides the most effective pain relief for the patient. distraction is one of the non-pharmacological methods used in pain control. distraction is one of the most preferred methods to reduce pain in patients during diagnosis and treatment procedures. it is a method that allows patients to control and reduce the symptoms they experience by focusing their attention on a different point.the aim of this study is to examine the effect of using a motivational video with virtual reality glasses to distract attention during the biopsy procedure on pain, stress and fear in individuals with suspected thyroid cancer.

research type: it was designed as a randomized controlled experimental study. research population and sample: the research sample will consist of patients with suspected thyroid mass who applied to a university hospitals. the sample of the research is aimed to be 100 volunteer diabetic patients who applied to the university hospital.

Eligibility criteria:
inclusion criteria: * patients with suspected thyroid mass * no dizziness problem * no vision problems exclusion criteria: * mental health problems that may prevent wearing virtual reality glasses

Keywords: thyroid cancer virtual reality therapy ultrasound thyroid nodule fine needle aspiration biopsy
complementary and alternative care in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this is a prospective, observational study designed to describe disease progression, symptom change, quality of life, diet and lifestyle habits, and frequency of adverse events among patients with multiple sclerosis (ms) who use complementary and alternative medicine (cam). in addition to describing the patterns of cam use, this study will also identify and describe the positive deviants, those individuals with the highest quality of life and least amount of disease activity. positive deviants will be compared to controls in order to describe medication, diet, and lifestyle patterns associated with a lack of ms disease progression and high quality of life.


Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis (including relapsing remitting ms, secondary progressive ms, primary progressive ms, clinically isolated syndromes (cis), radiologically-isolated syndromes (ris), possible ms, or probable ms. * age 18-100 exclusion criteria: * inability to read/write in english * inability or unwillingness to complete surveys every six (6) months. (\~ 90 min)

Keywords: multiple sclerosis ms complementary and alternative cam
effects of altering handle height of posterior walkers

Conditions: Cerebral Palsy

Summary: the aims of this study are to investigate what effect altering handle height of posterior walkers has on forces through the walker, posture, efficiency, stability, speed, turning and comfort, and to obtain data which helps therapists understand the bio-mechanics involved during use and if this alters depending on age, posture or strength. all participants will have cerebral palsy. this will allow informed prescription of walkers and identify potential for redesign to improve efficiency, promote strengthening or improve posture to maximise children's potential to continue functional walking into adulthood.

children with cerebral palsy (cp) find walking effortful due to weakness, lack of coordination between muscle groups, postural changes, poor balance and altered muscle tone. walking aids improve efficiency, stability and posture.posterior walkers were developed in the mid 1980's. there is evidence of their advantages over more traditional anterior walkers, however there is no evidence relating to setting handle height, and little information about bio-mechanics during use. this is a quantitative pilot study with a cross over design. a purposive sample of approximately 15 children will be recruited from birmingham community healthcare national health service (nhs) trust. assessments will be carried out at 3 different handle heights, determined by measuring elbow flexion when the participant is standing holding the handles of their walker. participants will attend two assessments. one at their school, and a second at the university of birmingham. forces going through the walker and the participant's feet, range of motion at the trunk, hip and knee, velocity, step and stride length, double support time, physiological cost index, pain, gross motor function, hip abductor strength and ease of turning will be measured. analysis of variance with repeated measures will be used to analyse changes across handle heights and multiple linear regression to show associations between the dependent variables studied and identify potential confounding factors. p\<0.05 will be considered statistically significant. effect sizes needed for clinical significance will be considered.

Eligibility criteria:
inclusion criteria: * diagnosis of spastic cerebral palsy by a medical practitioner from clinical presentation. * aged 5-18 years. * able to walk 50m with a posterior walker without rest. * uses a posterior walker at least once a week. exclusion criteria: * aged below 5 years or over 18. * orthopaedic surgery in the last 6 months, serial casting or botulinum toxin injections in the 12 weeks prior to or during the study, as gait could vary significantly following these interventions. * unable to walk 50m in a straight line and follow verbal prompts to turn. * insufficient understanding, in the opinion of their carer or therapist, to complete faces rating scale.

Keywords: cerebral palsy walking aids
working memory and social-emotional training for preschoolers at risk of adhd

Conditions: ADHD; Time Perception Altered; Working Memory; Social Skills

Summary: the study aims to explore the effectiveness of working memory training and social emotional training for young children with adhd in hong kong. this study will contribute to the current understanding of the alternative treatments for adhd, and hopefully help to mobilize more resources to be dedicated to the support of children with adhd. the programme includes the following components: children participating in this study will be randomly allocated into experimental group - recieving working memory training, active control group - receiving social-emotional training, and waitlist control group. all participants will complete a 5-week online training using a digital device at home, three times a week, each training session lasts for about 15 minutes. moreover, children's cognitive abilities and academic performance will be assessed prior to the intervention, and immediately after the 5-week training. each assessment session lasts for about 45 minutes. parents will also be asked to fill out a questionnaire on children's behaviours at home and school prior to and after the 5-week program. it takes about no more than 10 minutes. all assessments will be conducted at the laboratory at the university of hong kong. children's working memory, time perception, adhd symptoms, and early academic performance will be measured before and after training, and the between-group performance will be compared to examine the training effects.


Eligibility criteria:
inclusion criteria: * children aged 4-6 years old * with psychiatrist or psychologist diagnosis of adhd according to the dsm-5 manual or other clinical diagnosis criteria; * or as indicated by the ratings of swanson, nolan and pelham parent rating scale (snap-iv; chinese version); * with normal iq (above 80), which enable them to understand the materials delivered in the training program; * children either not taking any medication or taking a stable dosage of medication for adhd for at least 3 months prior to the study enrollment and will not be taking the medication during the training and post-assessment period. exclusion criteria: * inability to comprehend cantonese, with comorbid disorders (i.e. autism, conduct/behavioural problems), * with medical or other mental health condition * with iq below 80 * with physical and motor disabilities that restrain them from completing the tasks.

Keywords: preschool adhd working memory