Kornimate/medical-research-clean huggingface dataset:
trajectories of resilience and bariatric surgery outcomes

Conditions: Severe Obesity; Psychological Distress; Bariatric Surgery Candidate

Summary: a high prevalence of psychological trauma on one hand and of psychiatric disorders, such as depression, anxiety, suicide attempts, addictions, and eating disorders on the other hand, has been reported in patients with severe obesity seeking bariatric surgery. some studies reported an increased prevalence of these psychiatric disorders after bariatric surgery, potentially related to weight regain. in this context, psychological resilience is a concept that brings together internal and external factors of adaptation, and whose clinical use facilitates interdisciplinary collaborative work. this research focuses on the association between resilience and success or failure of bariatric surgery in patients followed in the specialized obesity center (cso) of the nancy university hospital. the hypothesis is that psychological resilience before surgery promotes successful surgical treatment. this retrospective study is based on existing data from patients with severe obesity who have undergone bariatric surgery at the nancy cso. the main objective is to study 1) the resilience of patients with severe obesity, candidates for bariatric surgery, at the first assessment (t0), at the end of lifestyle/behavioral modifications program (t1) and at 2 years after bariatric surgery (t2), 2) the relationship between internal and external factors explaining resilience and final weight outcomes. the investigators are expected that non-resilient patients have more psychological vulnerabilities (psychopathology, negative life events, etc.), and have lower weight loss than resilient patients.

the investigators will report the change of resilience during lifestyle/behavioral modifications program and 2 years after bariatric surgical treatment, and the investigators will describe the factors associated with this change: * history of trauma * psychopathology (eating disorders, depression, anxiety, addiction) * personality factors * characteristic of psychotherapy

Eligibility criteria:
inclusion criteria: * severe obesity (bmi ≥35 kg/m2) * candidate for bariatric surgery at nancy cso (2016-2020) after a lifestyle/behavioral modifications program * full psychological assessment data exclusion criteria: * patient's opposition to the use of data for research purposes

Keywords: severe obesity resilience trauma psychological disorders eating disorders bariatric surgery
comparing intravenous and oral paracetamol for cholecystectomy

Conditions: Laparoscopic Cholecystectomy

Summary: to determine the amount of paracetamol in the blood when given in either intravenous or oral forms prior to cholecystectomy. the clinical effectiveness of each form will also be evaluated with pain scores and the use of other pain relief drugs.


Eligibility criteria:
inclusion criteria: * males and females aged 18-75 * scheduled to have elective laparoscopic cholecystectomy under general anaesthesia exclusion criteria: * inadequate english comprehension (difficult to obtain informed consent and cooperation), and when interpreters are not available. * history of allergy or sensitivity to paracetamol * administration of oral paracetamol within previous 8 hours * american society of anesthesiologists (asa) grade iv or v, indicating serious cardio-respiratory co-morbidity * not suitable for protocol anaesthetic technique (eg: history of nausea and vomiting with morphine)

Keywords: paracetamol acetaminophen pharmacokinetic intravenous oral analgesia pain opioid
evaluating the effectiveness of ondansetron versus dexamethasone versus placebo for the control of intraoperative nausea and vomiting in patients undergoing lower-segment caesarean section under spinal anesthesia

Conditions: Caesarean Section; Spinal Anesthesia

Summary: the goal of this randomized controlled trial is to evaluate the effectiveness of ondansetron, dexamethasone, and placebo for intraoperative nausea and vomiting in patients undergoing caesarian section under spinal anesthesia. the main question it aims to answer are: which drug is the best at reducing the incidence of intraoperative nausea and vomiting. which drug is the best at reducing intraoperative pain. participants will be randomly divided into three groups, each will be given a different drug labelled a, b, or c. a rating scale will be used to evaluate the severity of intraoperative nausea and pain. episodes of vomiting will be recorded. data collected from the three groups will be analyzed using spss software.


Eligibility criteria:
inclusion criteria: * age above 20 but less than 35 years old * given informed consent * no contraindication to spinal anesthesia * asa i or ii exclusion criteria: * age less than 20 or more than 35 years old * non-consenting * contraindication to spinal anesthesia * asa iii or iv
confocal endomicroscopy for gi neoplasia study

Conditions: Colorectal Polyps

Summary: the purpose of this study is to enhance probe stabilization using a 4mm clear cap attached to endoscope in comparison to standard "free-hand" image acquisition.

the aim of this study is to optimize and validate in-vivo imaging systems capable of highly accurate, real-time classification of colorectal neoplasia.

Eligibility criteria:
inclusion criteria: * those patients undergoing colonoscopy for screening or surveillance of colon polyps will be included in this study. exclusion criteria: * patients with known polyposis syndromes, inflammatory bowel disease, allergy to fluorescein, or refusal to provide informed consent.

Keywords: polyps inflammatory bowel disease associated neoplasia
lynch syndrome integrative epidemiology and genetics

Conditions: Lynch Syndrome

Summary: the vision of the "lynch syndrome integrative epidemiology and genetics" (lineage) consortium is to collaboratively improve the lives and longevity of individuals and families with lynch syndrome. the mission of the lineage consortium is to collaboratively improve lynch syndrome care through high-quality research. this consortium will provide intellectual and infrastructure support to facilitate development of research questions, collection of standardized data and biospecimens, support of grant applications, and generation of collaborative manuscripts. our aims are to: i. establish a prospective cohort of individuals with lynch syndrome ii. collect standardized longitudinal clinical and biosample data to elucidate lynch syndrome epidemiology and gene-host interactions iii. promote intervention trials to improve cancer prevention and early detection in lynch syndrome

the main objective of this consortium is to build a shared resource to drive research in critical areas necessary to understand ls-related neoplasia risk and improve early detection and prevention of ls-associated cancers. this consortium will provide intellectual and infrastructure support to facilitate development of research questions, collection of standardized clinical data and biospecimens, support grant applications, and generate collaborative manuscripts. data and samples collected for lineage will allow the consortium to address a variety of topic areas including but not limited to: i. risk of prevalent and incident colorectal neoplasia among pv/lpv carriers. ii. estimate risk of prevalent and incident extra-colonic neoplasm among pv/lpv carriers. iii. characterization of post-colonoscopy colorectal cancer among pv/lpv carriers. iv. risk factors for prevalent and incident neoplasia. the lineage consortium is an observational prospective cohort study, with baseline and annual electronic health record (ehr) abstraction, and electronic participant and provider surveys. the consortium may also collect single or serial biosamples from identified and enrolled ls patients at participating centers.

Eligibility criteria:
inclusion criteria: * • adults age over 18 years * eligible patients must have at least one variant of uncertain significance (vus), pathogenic or likely pathogenic variant (pv/lpv) in mlh1, msh2, msh6, pms2, or epcam, which will be confirmed by genetic testing results (obtained as part of routine care) and a review of the variant in clinvar (https://www.ncbi.nlm.nih.gov/clinvar/). * individuals who are an obligate carrier of a ls pv/lpv that is confirmed in the family. exclusion criteria: * age under 18
work interventions to improve employment outcomes for persons with rheumatoid arthritis and osteoarthritis

Conditions: Osteoarthritis; Rheumatoid Arthritis

Summary: to determine if worksite based functional evaluation/intervention provided by occupational therapists improves employment outcomes for persons with arthritis.

arthritis is second only to heart disease as a cause of work-related disability with significant financial costs associated with the loss of work for persons with arthritis. many persons with arthritis have physical impairments which affect their ability to work, with 50% of persons with rheumatoid arthritis leaving employment within 10 years of diagnosis. risk factors predicting employability, length of employment and worksite accommodations for workers with arthritis have been well documented. variables predicting work cessation include blue collar jobs and more physically demanding jobs, an older age of the worker, lower education, perceived job strain, social support of co-workers and supervisors, job satisfaction, and self-efficacy. recent studies of self-report by persons with arthritis identified the use of worksite accommodations such as others providing assistance at work, job autonomy, time flexibility, and use of special equipment. unknown is the effect of on-site work interventions. the need exists to determine if the provision of strategies for physical accommodations, worksite modifications, and assistive technologies at the individual's job site improves the ability of persons with arthritis to continue working. this is a randomized clinical trial to investigate the efficacy of a worksite based intervention to improve the employment outcomes of persons with rheumatoid (ra) or osteoarthritis (oa). persons with ra or oa who have arthritis related work difficulties will have an occupational therapist provide a worksite evaluation and subsequent training in strategies to accommodate arthritis related physical impairments and improve job performance and satisfaction. participants in control group will be provided with educational printed materials related for a self-initiated worksite evaluation of musculoskeletal and environmental risks at the worksite for persons with arthritis.

Eligibility criteria:
inclusion criteria: * rheumatoid arthritis or osteoarthritis diagnosed by a rheumatologist * competitively employed; full or part time * reporting arthritis-related employment difficulties * agree to participate in a work site evaluation exclusion criteria: * systemic complications of ra (e.g., vasculitis) * organic brain syndrome * uncontrolled psychiatric disorders * uncontrolled medical conditions (e.g., active cancer)

Keywords: employment work
aav9 u7snrna gene therapy to treat boys with dmd exon 2 duplications.

Conditions: Duchenne Muscular Dystrophy

Summary: open-label, single dose clinical trial of scaav9.u7.acca via peripheral limb vein injection for duchenne muscular dystrophy boys who have a duplication of exon 2.

the proposed clinical trial is a systemic (intravenous) delivery of scaav9.u7.acca for dmd patients with a duplication of exon 2 in the dmd gene. preclinical data shows that the small nuclear rna (snrna) construct delivered by the scaav9.u7.acca vector causes significant skipping of exon 2, resulting in exclusion of the exon from the mature messenger rna (mrna) with a high degree of efficiency, leading to mrna containing only a single exon 2 (wild type \[wt\] mrna) or no copies of exon 2 (del2 mrna). translation of the wild-type mrna results in entirely normal dystrophin protein, whereas translation of the del2 mrna via translational initiation of an internal ribosome entry sequence, or ires) results in a highly functional isoform expressed in patients known to walk into their eighth decade. the study is designed as an open-label trial to assess safety and obtain preliminary efficacy data. scaav9.u7.acca will be delivered to the systemic circulation via peripheral limb vein.

Eligibility criteria:
inclusion criteria: * age greater than 6 months and less than 14 years * confirmed duplication of exon 2 in the dmd gene using a clinically accepted technique that completely defines the mutation * pre-ambulant (not yet walking) or ambulant (as defined by the ability to walk 10 meters without assistance) * males of any ethnic group will be eligible * ability to cooperate with muscle testing * in subjects age 4 and above, stable dose and regimen of corticosteroid therapy (prednisone, deflazacort, or their generic forms) for at least 12 weeks prior to gene transfer. exclusion criteria: * active viral infection based on clinical observations * symptoms or signs of cardiomyopathy, including: 1. dyspnea on exertion, pedal edema, shortness of breath upon lying flat, or rales at the base of the lungs 2. echocardiogram with ejection fraction below 40% * serological evidence of hiv infection, or hepatitis b or c infection * diagnosis of (or ongoing treatment for) an autoimmune disease * persistent leukopenia or leukocytosis (wbc ≤ 3.5 k/µl or ≥ 20.0 k/µl) or an absolute neutrophil count \< 1.5k/µl * concomitant illness or requirement for chronic drug treatment that in the opinion of the si creates unnecessary risks for gene transfer * aav9 binding antibody titers ≥ 1:400 as determined by elisa immunoassay * abnormal laboratory values in the clinically significant range as listed in table 7, based upon normal values in the nationwide children's hospital laboratory.
cytomegalovirus spread and reactivation in blood cells

Conditions: Blood Disease; Cytomegalovirus Infections

Summary: to investigate the relationship between hcmv and bone marrow progenitor cells to understand whether hcmv is latent in cd34 + bone marrow progenitors and the mechanism by which the virus remains in a latent state.

background: despite progress in understanding the pathophysiology of human cytomegalovirus (hcmv) infections, its manifestations in the immune compromised host are frequently associated with high morbidity and mortality. in this setting, hcmv disease can develop e.g. following immune suppression as a result of reactivation of latent hcmv acquired earlier in life. the mechanisms leading to establishment of latent infections and their subsequent reactivation are not clear. it is also unknown whether hcmv exists in a latent form with limited viral gene expression or as a persistent infection with normal virus transcription. design narrative: the specific aims of the study were to: 1) examine the percentage of hcmv positive donors whose bone marrow progenitors contained hcmv dna using nested pcr and determine if virus could be rescued from those cells. 2) analyze the hcmv life cycle in hematopoietic progenitor and stem cells. 3) identify and analyze hcmv gene expression in in vivo infected leukocytes. bone marrow progenitors containing hcmv dna detectable by nested pcr were isolated from human donors and used as as source of mrna to prepare cdna libraries. 4) determine if gene(s) expressed in bone marrow progenitors were important in either establishing or maintaining a latent infection or in the lytic cycle of hcmv. information provided from the above studies yielded information important in planning future approaches for the therapy of hcmv infections. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
mra/fmri study of spontaneous migraine

Conditions: Headache Versus Non-headache Day

Summary: the purpose of this study is to examine migraineurs during spontaneous migraine attacks without aura, using high resolution magnetic resonance imaging (mri), to study following: * changes in resting state blood-oxygenation-level-dependent-signal (bold-signal) using functional mri (fmri). * changes in circumferences of intra- and extracranial arteries using mr-angiography (mra). * changes in regional and global cerebral blood flow (cbf) using the arterial spin labeling (asl) method. moreover to perform diffusion tensor imaging (dti) scans during spontaneous migraine attacks. the migraine specific drug sumatriptan will be given to relieve pain and the effect will be registered using mra and fmri if possible.


Eligibility criteria:
inclusion criteria: * migraine without aura according to ihs criteria. exclusion criteria: * other primary headaches. * tension-type headache more than 5 days/month. * use of anti-pain medication before the scanning on the examination day. * pregnant or nursing women. * contraindication for mr scan. * anamnestic or clinical signs of cardiovascular or cerebrovascular disease, unregulated psychiatric disease or drug misuse. * other clinical conditions assessed by the examining doctor.
reducing preoperative anxiety in parents of surgical patients

Conditions: Anxiety

Summary: aims and objectives: to investigate preoperative anxiety in parents of paediatric surgical patients, testing whether the provision of information (using video and story books) regarding the surgical process can impact on reducing anxiety. analyse if some personal factors influence the reduction of anxiety. background: attending a surgical theatre generates anxiety in all types of patients, especially in the case of children. the effect of different preoperative intervention procedures in children that attempt to reduce their anxiety level have been studied a great deal. however, although their parents also suffer high anxiety levels, potential intervention to reduce their levels have not received the same attention. study design: randomised clinical trial methods: one hundred and twenty-five parents of children (8-12 y.o.) undergoing surgery in hospital universitario central de asturias hospital (oviedo, spain) were randomly assigned to the control group (34 individuals) or one of the 3 experimental groups (91). after the pre-anaesthesia consultation, children and parents of the experimental groups were provided with a story book, a video with additional information of nursing, or both. in the antechamber of the operating room and prior to the surgical intervention, the state anxiety and trait anxiety of the parents and children were measured using the stai and staic questionnaires respectively. the data collection, including different demographic variables was carried out for 12 months starting in october 2016


Eligibility criteria:
inclusion criteria: * undergoing surgery at asturias central hospital exclusion criteria: * children not in the age range, * emergency surgery, * children not able to understand or read * parents not present or refused to participate.
effects of transcranial direct current stimulation on cigarette addiction

Conditions: Addiction

Summary: tobacco addiction is treatable with behavioral and pharmacological means, but results are often less than optimal. transcranial direct current stimulation is a new non-invasive technique that applies weak electrical currents through the skull and has been shown to alter the excitability of certain brain areas. it is currently being tried in disorders where there is abnormal brain excitability, such as epilepsy and depression. a few studies have also been able to diminish drug craving, suggesting that brain excitability might also be altered in drug addiction. this study aims at non-invasively changing the excitability of certain brain areas-a procedure called neuromodulation- in order to help smokers quit smoking more easily.


Eligibility criteria:
inclusion criteria: * smokers exclusion criteria: * use of psychoactive drugs * age above 70

Keywords: cigarette smoking, smoking
effectiveness to weight loss in sedentary and overweight people using a smartphone application.

Conditions: Healthy

Summary: this is a randomized clinical trial aimed at obese and sedentary subjects aged 20 to 65 years selected in urban primary care centers of 5 centers (spain). its objective is to evaluate the effects of the addition of an ict tool developed for the smartphone application and a smartband in support of behavioral and educational recommendations to reduce weight.

* objetive: to develop and validate an application for the use in smartphone in which the management of a smartband is included and evaluate the effect of adding this tool of information and communication technology (ict), to a standardized intervention reduce weight, reduce sedestation time, increase physical activity and decrease total caloric intake in obese and sedentary subjects. * design and setting: a clinical of two parallel group, multicenter, randomized, aimed at assessing the effects of adding an ict tool (intervention) to support behavioral and educational recommendations (control) in physical activity and weigh loss. population: 700 obese and sedentary subjects will be included, 20 to 65 aged, selected by random sampling in 5 centers. * measurements and intervention: physical and sedeentary acivity will be assessed with an accelometer and ipaq and marshall questionnaires, the nutrition by a food frequency and adherence to the mediterranean diet survey and weight loss with body mass index and waist circumference. vascular function with a wrist-worn tonometer (blood pressure, augmentation index and pulse rate) will be evaluated and also the cardio ankle vascular index and carotid intima media thickness. the advice on nutrition (plate method) and exercise will be common to both groups. the intervention group will be added a training for 3 months in use of ict tool described, designed to foment a healthy and low-calorie diet and increased physical acivity and decreased sedentary.

Eligibility criteria:
inclusion criteria: * obese subjects (imc ≥ 27.5 to \<40), classified as sedentary according to the short physical activity questionnaire validated in the evident ii study. exclusion criteria: * older than 65 years are excluded, due to difficulties in the use of icts. * advanced respiratory, renal or liver disease. * several mental illness * coronary or cerebrovascular atherosclerotic disease, grade ii or higher nyha heart failure. * moderate or severe copd * muscular-skeletal pathology that inhibit mobility * subjects who can not exercise or follow a hypocaloric diet. * oncologic disease in treatment diagnosed in the last 5 years. * terminal situation * pregnancy * bariatric surgery * those with any other circumstance that the investigators consider could interfere with the study procedures

Keywords: physical activity food habits information and communiation technology health education