Kornimate/medical-research-clean huggingface dataset:
swiss neonatal network & follow-up group

Conditions: Very Low Birth Weight Infant; Very Preterm Maturity of Infant; Asphyxia Neonatorum

Summary: the chief aim of the swiss neonatal network \& follow-up group (swissneonet) is to maintain and / or improve the quality and safety of medical care for high-risk newborn infants and their families in switzerland through a coordinated program of research, education and collaborative audit. in support of its aim, swissneonet hosts the official medical quality register for the swiss level iii and level iib units. participation for these units is mandatory according to the intercantonal declaration for highly specialized medicine (hsm) of september 22, 2011 and the society's standards for levels of neonatal care in switzerland.

inaugurated in 1995, swissneonet now routinely collects data from 9 level iii, 10 level iib and 14 neuro-/developmental pediatric units encompassing information about the care and outcomes of high-risk newborn infants. data collection is monitored for population coverage, dataset completeness, plausibility and reliability. data quality is audited within a three year cycle. quality improvement swissneonet releases an annual quality report for participating centers encompassing up to 20 process- and outcome quality indicators. it annually collects data on unit infrastructure evaluated by the committee for the accreditation of neonatology units (canu). to discuss quality issues and educational purposes, it hosts bi-annual meetings/symposia for the neo directors group and the follow-up group, respectively. the swissneonet member platform offers tools for unit-to-unit quality improvement collaboration (mailing lists, event-organizer, forum, file-sharing and survey builder). research swissneonet coordinates cross-sectional and longitudinal cohort studies that are performed by local researchers using swissneonet's prospectively collected data. these studies focus on mortality, morbidity and/or long-term outcome issues and the analysis of risk factors for development. the network disseminates its research in scientific articles in peer reviewed medical journals. support swissneonet supports the units logistically to ensure that each patient receives primary care (nicu bed availability) and follow-up assessments at 9 to 12 months corrected, 18 to 24 months corrected, and at 5.5 to 6 years of age (fu missing lists) to ensure early diagnosis and intervention. with regards to its follow-up program, the swissneonet also supports training of new staff and coordinates the launch of new testing instruments between centers.

Eligibility criteria:
inclusion criteria of "minimal neonatal dataset" (mnds): all swiss live-born infants below 32 weeks gestational age or 1501g birth weight inclusion criteria of "below 34 data collection", (b34): all swiss live-born infants between 32 0/1 and 33 6/7 weeks gestational age that are above 1500g birth weight inclusion criteria of "swiss asphyxia and cooling registry", (asp): infants between 35 0/7 and 42 6/7 weeks' gestational age with moderate or severe encephalopathy due to perinatal asphyxia
a clinical study of the cardiaq™ tmvi system (transapical ds)

Conditions: Mitral Insufficiency; Heart Valve Disease; Cardiovascular Disease; Heart Disease

Summary: the purpose of the study is to evaluate the initial short and long-term safety and performance of the cardiaq™ transcatheter mitral valve implantation system using the transapical delivery system. the study will enroll patients with moderate to severe mitral valve regurgitation who are considered high or extreme risk for mortality and morbidity from conventional open heart surgery.


Eligibility criteria:
key inclusion criteria: * nyha classification ≥ iii * left ventricular ejection fraction ≥ 30% * mitral regurgitation ≥ grade 3+ * subject meets anatomical eligibility criteria for the investigational device

Keywords: transcatheter mitral valve replacement mitral regurgitation mitral insufficiency transapical
improving how people living with dementia are selected for care coordination

Conditions: Dementia

Summary: many people living with dementia (plwd) and their care partners may benefit from the assistance of a care coordinator, a member of the medical team who facilitates communication among all the people involved. however, care coordinators' time is limited, and there is uncertainty about which patients should be selected to receive their help. this pragmatic clinical trial embedded in an accountable care organization will determine the comparative effectiveness of two approaches for assigning care coordinators to plwd.

this project will use a pragmatic clinical trial embedded in an accountable care organization (aco) to determine the comparative effectiveness of two different approaches for selecting plwd to receive support from care coordinators: (1) an approach that assigns plwd to care coordinators based on care partners' self-reported difficulty with care coordination, or (2) usual care, which generally assigns plwd to care coordinators after hospital discharge, regardless of perceived need. the investigators will include community-dwelling medicare beneficiaries ≥65 years old with dementia who have been attributed to the newyork quality care aco and who have fragmented care. the investigators will randomize the participants into two groups. this study is highly pragmatic, and the intervention is sustainable and scalable. moreover, the proposed approach has the potential to improve care delivery and outcomes for plwd.

Eligibility criteria:
inclusion criteria: * medicare beneficiaries ≥65 years old who: * are attributed to the newyork quality care accountable care organization by medicare, * have dementia (as measured in claims using the bynum standard 1-year definition), * reside in the community, and * had fragmented ambulatory care in the previous 12 months (defined as a reversed bice-boxerman index greater than or equal to the median score for this population, using medicare claims) exclusion criteria: * those who reside in long-term care or nursing home facilities (based on addresses in medicare claims), or * enrolled in home hospice

Keywords: care coordination accountable care organization
clinical significance and coexistence of polymorphisms of individual collagen-coding genes

Conditions: Ligament; Laxity; Recurrent Patellar Dislocation

Summary: the purpose of this study is to assess correlation between recurrent patella dislocation and genetic polymorphism rs1800012 of the col1a1 gene and rs12722 of the col5a1 gene.

after being informed about the study and potential risk all of participants were performed phisical examination and genetic test. in the study we established two groups: in first group- 50 patients with recurrent patellar dislocation and without any genetic disorders. in the second one 200 patients without recurrent patellar dislocation and genetic disorders. all pediatric patients were between 7 and 17 years old in two groups respectivly.

Eligibility criteria:
inclusion criteria: • first-time diagnosed or recurrent patellar dislocation patient from 7 to 17 age years old. exclusion criteria: * patient's age under 7. * presence of genetic diseases such as: down's syndrome or marfan's syndrome. * metabolic disorders. * previous knee surgeries. * cartilage and bone fractures in the knee. * no consent for examination from the legal guardian.
the role of ultrasonography in pregnancy in the study of fetal central nervous system malformations

Conditions: Malformation Brain

Summary: the aim of this observational study is to evaluate the correlation between new ultrasound patterns and fetal central nervous system (cns) malformations.

during fetal life, the cns undergoes major changes, so it is important to study the evolution of brain morphology serially during intrauterine life. despite numerous data in the literature, prenatal ultrasound diagnosis of cns malformations is often difficult due to the presence of imaging pictures that are nondiagnostic or difficult to interpret. moreover, only some of the sonographic features of cns malformations have been described in detail. therefore, it is essential to study and describe the ultrasound pictures in order to identify new ultrasound patterns useful to identify the fetal malformation more clearly. therefore, this study aims to retrospectively analyze the ultrasound images of fetuses with established brain malformations and compare them with those of healthy fetuses in order to highlight the presence of new ultrasound patterns, which may more clearly define the malformative pathology. ultrasound images routinely performed in pregnancy in fetuses with brain malformation and in healthy fetuses will be reviewed. for each patient, information will be collected on: * age * previous pregnancies and their outcome * pregnancy arising spontaneously or through medically assisted procreation techniques * family history of congenital malformation * type of central nervous system malformation (neural tube defects, holoprosencephaly, corpus callosum agenesis, cerebellar malformations, posterior cranial fossa cysts, other malformations) * gestational age at the time of diagnostic suspicion * gestational epoch at the time of diagnosis * pregnancy outcome (miscarriage, voluntary termination of pregnancy, spontaneous delivery or cesarean section) * presence of associated abnormalities affecting other anatomical districts for each newborn, information will be collected on: * sex * weight * umbilical artery ph * apgar index at 5 and 10 minutes * neurological assessment in the immediate postpartum period * perinatal mortality

Eligibility criteria:
inclusion criteria: * women older than 18 years with single pregnancy and fetus with ultrasound diagnosis of central nervous system malformation (group a) * women with single pregnancy and normoconformed fetuses (group b). exclusion criteria: * twin pregnancy

Keywords: prenatal ultrasounds
effect of apl180 on endothelial function in familial hypercholesterolemia patients

Conditions: Familial Hypercholesterolemia

Summary: this study will evaluate the effect of apl180 on endothelial function measured by forearm venous occlusion plethysmography in patients with familial hypercholesterolemia.


Eligibility criteria:
inclusion criteria: * confirmed presence of familial hypercholesterolemia * women must be sterilized or post-menopausal exclusion criteria: * smoking an average of greater than 10 cigarettes per day * history of cardiac events * very low or high body weight * treatment with fibrates or niacin * high blood triglyceride levels other protocol-defined inclusion/exclusion criteria may apply.

Keywords: familial hypercholesterolemia, endothelial function, venous occlusion plethysmography, forearm blood flow, apoai-mimetic, endothelial dependent vasodilation
foot spine syndrome "raffet syndrome"

Conditions: Chronic Low-back Pain; Hallux Rigidus

Summary: case series aimed to describe a new clinical condition for the first time in the medical literature called foot spine syndrome or "raffet syndrome". this syndrome was reported in 11 patients (6 males and 5 females) out of 4000 patients with a history of chronic low back pain (clbp) throughout 2 to 6 years in an outpatient clinic in egypt from 2016 to 2022.

foot pain is usually derived from systemic disorder or local physical issues, such as tendonitis, arthritis, or bursitis. however, in some cases, pain in your foot may be linked to problems in your spine. this case series aimed to describe a new clinical condition for the first time in the medical literature called foot spine syndrome or "raffet syndrome". this syndrome was reported in 11 patients (6 males and 5 females) out of 4000 patients with a history of chronic low back pain (clbp) throughout 2 to 6 years in an outpatient clinic in egypt from 2016 to 2022. the patients suffered from clbp that did not respond to physical therapy or any medication for long. they all had clinical spinal instability, hallux rigidus, foot abnormalities and tightness of hip flexors and adductors accompanied with weakness of hip extensors and abductors on the affected side. manual therapy for the big toe including; maitland mobilization (grade 3,4), mulligan mobilization with movement techniques, muscle energy techniques, manual therapy for plantar fascia, strengthening exercises and self-stretching exercises was performed.

Eligibility criteria:
inclusion criteria: * patients with a history of chronic low back pain (clbp) did not respond to physical therapy or any medication for long. they all had clinical spinal instability, hallux rigidus, foot abnormalities and tightness of hip flexors and adductors accompanied with weakness of hip extensors and abductors on the affected side exclusion criteria: * any structural deformity (wedge fracture) or previous spinal surgeries. spinal tumors or fracture or presence of active infection in the lumbar spine. systematic disorder (rheumatoid) cauda equine lesion, the presence of any comorbidities such as hypertension, dm, hyperlipidemia, obesity, and any autoimmune disease, history of patients who suffered from cancer, unexplained weight loss, immunosuppression, prolonged use of steroids, intravenous drug use, urinary tract infection, pain that is increased or unrelieved by rest, fever, significant trauma related to age, bladder or bowel incontinence, urinary retention (with overflow incontinence), saddle anesthesia, loss of anal sphincter tone, major motor weakness in lower extremities, fever, and vertebral tenderness.
priority to cryopreservation strategy (pcs) in ivf-icsi cycles

Conditions: Infertility; IVF; ICSI; Cryopreservation

Summary: this multicentre randomized controlled trial will be done to evaluate a new strategy in ivf-icsi practice that gives that priority to freeze for the embryos and goes to fresh embryo transfer only if at least one set of same quality embryos is available for cryopreservation.

this study will be a non-blind, prospective, double-armed, randomized clinical trial. the study will be conducted at five centers, the educational hospital fertility unit of tanta university, the fertility center of cairo university, the fertility center of assiut university, the egyptian consultants fertility center in tanta, and mrc fertility center in cairo from may 1st 2019 till the end of the objected number. the study will be conducted in accordance with the declaration of helsinki, and all participants should sign a written informed consent before inclusion in the study.

Eligibility criteria:
inclusion criteria: * candidates for ivf/icsi * presence of good number of embryos \> 5 exclusion criteria: * low quality embryos * low ovarian reserve * low number of embryos
screen-and-treat program for chronic kidney disease- high risk persons

Conditions: Hypertension

Summary: the overall hypothesis of this trial is that screening for chronic kidney disease, followed by education or treatment program will improve blood pressure control among hypertensive non-diabetic persons.

to evaluate a ckd screen-and-educate program in primary care for improving blood pressure management compared with usual care, among non-diabetic adults with hypertension.

Eligibility criteria:
inclusion criteria: the entire primary care medical practice at sfvamc will be considered. randomization will occur at the team (nurse) level. within each team, individual patients will be considered eligible for chronic kidney disease screening by this protocol and inclusion in our trial if they have hypertension without concomitant diabetes, and no prior recorded diagnosis of chronic kidney disease. hypertension will be defined as systolic blood pressure \>140 or diastolic blood pressure \>90 mmhg at more than two encounters (any encounter) within the previous 3 years or a documented diagnosis of hypertension (listed in problem list or icd-9 code). diagnosed chronic kidney disease will be defined as a documentation of chronic kidney disease in the problem list or icd-9 code or on-going nephrology follow up. we define diagnosed chronic kidney disease without consideration of estimated glomerular filtration rate by creatinine or albumin-creatinine-ratio in the laboratory section of the medical record, since work from our group and others has shown that awareness and recognition of chronic kidney disease is extremely low, even among persons with documented reduced estimated glomerular filtration rate or albuminuria. persons will be required to have seen their physician at least one time within the past 18 months. exclusion criteria: kidney transplant recipients, pregnant women, and individuals with an estimated glomerular filtration rate \ 80 will be excluded because data on aggressive blood pressure lowering in this population are less clear and adverse effects associated with aggressive blood pressure control have been well documented. we will exclude persons with new york heart association class iii or iv heart failure, known ejection fraction \<25%, or documented allergy to angiotensin-converting enzyme/angiotensin ii receptor blockers. other exclusion criteria relate to the required ability to communicate with providers and provide informed consent: prevalent dementia, impaired cognition or severe mental illness; expected life expectancy \<6 months; severe visual impairment in the absence of an available caretaker who can read.
eudaimonia and sleep: effects of a mindfulness intervention in caregivers of people with dementia

Conditions: Caregivers; Burnout; Sleep

Summary: this research study seeks to understand how stress reduction training influences caregiver well-being, sleep, and physiological responses to stress. all participants are caregivers of persons with dementia. participants will complete a 14-day, online stress-reduction intervention which involves approximately 25-30 minutes of daily practice.

the research project will be conducted over approximately 9 months and will consist of three data collection sessions for each participant. the three data sessions will occur before, after, and at 3-month follow-up of an 14-day, online stress-reduction training, in which participants will be asked to complete about 25 to 30 minutes of practice each day in one of two stress-reduction techniques. participants will be randomly assigned to either a mindfulness training program or a reappraisal training program. the mindfulness training emphasizes mindfulness-based techniques to reduce stress and promote well-being, whereas the reappraisal training emphasizes cognitive strategies to change one's perception of the stressor as a way to reduce stress and promote well-being.

Eligibility criteria:
inclusion criteria: * english speaking * self-reporting informal caregivers of persons with dementia exclusion criteria: * self-reported major depressive disorder with psychotic features * history of schizophrenia * bipolar disorder * uncorrected severe sensory impairments or chronic debilitating health problems that could hinder participating in the interventions * previous mbsr training or regular meditative practice within previous 6 months

Keywords: well-being sleep caregiver
comparison between nasal mask vs nasal prong on pain response in neonate

Conditions: Nasal Mask; Nasal Prong

Summary: to determine the comparison of nasal masks and nasal prongs on the pain response of neonate

to see the comparison of nasal masks and nasal prongs on the pain response of neonates, by measuring salivary cortisol levels before and after the intervention

Eligibility criteria:
inclusion criteria: * newborn with espiratory distress and need noninvasive respiratory support exclusion criteria: * syok, multiple congenital anomaly

Keywords: nasal mask, nasal prong, pain response
long covid-19 syndrome in primary care: a novel protocol of exercise intervention "con-vida clinical trial"

Conditions: COVID-19; Long COVID; Post-COVID-19 Syndrome

Summary: this is a randomized controlled trial of the efficacy of an individualized, progressive, exercise program (strength, cardiovascular, and breathing exercises) in recovering people from the post-covid-19 syndrome (i.e., patients who present symptoms \>12 weeks once the acute phase of the disease is over).

this is a randomized controlled trial of the efficacy of an individualized, progressive, exercise program (strength, cardiovascular, and breathing exercises) in recovering people from the post-covid-19 syndrome (i.e., patients who present symptoms \>12 weeks once the acute phase of the disease is over). the primary objective of the study is to evaluate the clinical efficacy and safety of a tailored exercise-based treatment relative to the control arm in improving the subject clinical status in both ambulatory and hospitalized post-covid-19 syndrome patients. the main novelty of this trial compared to other exercise-based interventions is the development and proof of concept of a progressively, levelled exercise regime for people with physical activity intolerance and fatigue symptoms.

Eligibility criteria:
inclusion criteria: * people over 18 years of age. * persistent symptoms of covid \>3 months of duration since infection. * have no medical contraindications incompatible with the practice of exercise. * do not meet the general 2020 recommendations for physical activity established by the world health organization2 (i.e., at least 150-300 minutes of moderate-intensity aerobic physical activity; or at least 75-150 minutes of vigorous-intensity aerobic physical activity; or an equivalent combination of moderate- and vigorous-intensity activity throughout the week). * provide signed informed consent. exclusion criteria: * presence of uncontrolled serious medical illness. * presence of any medical, psychological or social problem that could seriously interfere with the patient's participation in the study.