Kornimate/medical-research-clean huggingface dataset:
oral and maxillofacial pathology in pediatric patients

Conditions: Mouth Diseases

Summary: determination of the relative frequency of oral and maxillofacial pathological lesions among the egyptian children and compare it with the global reports.

oral and maxillofacial pathology in pediatric patients differs from the general population, as the nature of lesions in children changes with growth and development. oral and maxillofacial pathology encompasses a wide spectrum of diseases, some of which (i.e. aphthous ulceration, geographic tongue, and herpes labialis) can be diagnosed on clinical presentation alone. for other soft tissue diseases and for pathology with bony components, incisional or excisional biopsy is mandatory to establish a definitive diagnosis . several studies illustrated that oral and maxillofacial pathology in pediatric populations varies based on the geographic location of the population as racial and environmental specificities and the lifestyle of each population may influence the prevalence of these diseases . although there is increasing literature regarding the incidence and prevalence of pediatric oral and maxillofacial pathology, there is no study investigating the range and frequency in egyptian children.

Eligibility criteria:
inclusion criteria: * biopsy records for children aged from 0 to 18 years exclusion criteria: * biopsy records for patients older than 18 * incomplete record regarding age, gender, location

Keywords: oral pathology
operative plate fixation versus replacement for mason type iii fracture of radial head

Conditions: Radial Head Fracture

Summary: to compare the effect of operative plate fixation versus replacement for mason type iii fracture of radial head

from april 2015 to october 2016, patients with comminuted radial head fractures diagnosed as mason type iii are retrospectively included in this study, they were treated with either operative plate or radial head replacement. all the patients are regularly followed up in clinic. then we will compare the union rate and clinical functional outcome(mayo score) between the 2 groups at 1 year after surgery.

Eligibility criteria:
inclusion criteria: men or women aged 18 to 65 years of age with mason type iii radial head fracture are confirmed by radiograph within 1 month post injury provision of informed consent exclusion criteria: pathological fractures non-displaced (cortical contact) fractures open fractures presence of vascular or nerve injury fractures more than 1 month post-injury limited life expectancy due to significant medical co-morbidity medical contraindication to surgery inability to comply with rehabilitation or form completion likely problems, in the judgement of the investigators, with maintaining follow-up (i.e. patients with no fixed address, patients not mentally competent to give consent, etc.)

Keywords: radial head fracture replacement plate
the study of biomarker in early diagnosis of gdm by metabolomics

Conditions: Gestational Diabetes Mellitus; Metabolomics Detection; Biomarker in Early Diagnosis

Summary: gestational diabetes mellitus (gdm) refers to abnormal glucose metabolism during pregnancy, in which elevated blood glucose is first found during pregnancy and meets the criteria for diabetes. in recent years, with the increase of obese women of childbearing age, the incidence of gdm has been rising, the current global average incidence is about 14%, and the incidence in china has increased from 2% in 1999 to 5%-8% at present. if one-step diagnosis is used, the rate will be between 13%-17%, which will greatly increase the social burden. gestational diabetes mellitus (gdm) significantly increases the risk of diseases for pregnant women and infants, such as abortion and premature delivery, concurrent hypertension, concurrent infection, metabolic disorders, postpartum diabetes, macrosomia, fetal malformation, neonatal hypoglycemia, neonatal respiratory distress syndrome, and so on. it is one of the important public health problems threatening human health. therefore, the accurate diagnosis of gdm is of great clinical significance for the timely formulation of intervention and treatment measures, reducing the risk of maternal and infant diseases and improving the level of public health.

the study will follow a prospective cohort design and be conducted in peking union medical college hospital. all basic information was collected in the first trimester, and all subjects underwent ogtt (75g glucose) at 24-28 weeks of gestation. gdm will be diagnosed using the criteria of the iadpsg. at four time points during pregnancy (6-13 weeks, 24-28 weeks, 36-weeks before delivery, and 6 weeks after delivery), blood samples of 5ml were collected from each subject at each time point without increasing the number of blood samples. in the gdm group, blood samples were collected at the same time during routine visit 6 weeks after delivery. the relevant broad metabolomics and targeted vitamin profiles were also detected. meanwhile, blood glucose values at the corresponding time points were collected. using these variables, we will combine the metabolomics information to screen a predictive marker for gdm in chinese reproductive age population.

Eligibility criteria:
inclusion criteria: * first trimester (6-13 weeks)；pregnant women with a singleton pregnancy；pregnant women who are registered at the hospital and have regular antenatal check-ups；pregnant women who volunteered for the study were required to sign an informed consent form exclusion criteria: * pregnant women with known type 1 or type 2 diabetes mellitus；pregnant women with hyperlipidemia and hyperbilirubinemia；pregnant women with hepatic and renal insufficiency

Keywords: gdm metabolomics detection biomarker in early diagnosis
to investigate the relationship between the viscoelastic properties of the zona pellucida of human oocyte and the blastocyst utilization rate

Conditions: Oocyte; Zona Pellucida; Viscoelastic Property

Summary: in in vitro fertilization (ivf) treatment, oocyte quality is one of the key factors influencing the success rate of fertilization. the zona pellucida (zp) is a spherical structure that surrounds the human oocyte and, together with cumulus cells, forms the cumulus-oocyte complex (coc). these two components engage in bidirectional communication and metabolic regulation to support oocyte growth and maturation. additionally, the physical rigidity of the zona pellucida plays an important role in the fertilization process. opal x1 is a non-invasive and highly safe device specifically designed to measure the viscoelastic properties of the zona pellucida. this system consists of an ultra-precise pressure control mechanism and analytical software to assess oocyte quality before fertilization. opal x1 applies pressure through a micropipette while simultaneously recording the movement of the zona pellucida within the micropipette. an algorithm then analyzes the recorded motion images and classifies the oocytes into different quality grades (grade a, b, c). this study aims to investigate the correlation between oocyte classification results obtained from the opal x1 grading system and oocyte quality. by integrating spindle-view and time-lapse technology, the study seeks to identify the optimal parameters for oocyte quality assessment. furthermore, these findings will be applied to predict the success rate of intracytoplasmic sperm injection (icsi), the likelihood of blastocyst formation, and pregnancy outcomes after embryo transfer. ultimately, this study aims to provide more efficient and timely embryo development information before ivf, assisting clinicians in formulating and optimizing ivf treatment strategies.


Eligibility criteria:
inclusion criteria: 1. women who have started the in vitro fertilization (ivf) treatment and related examinations. 2. female participants aged ≤38 years with an anti-müllerian hormone (amh) concentration greater than 1.1 ng/ml and a collected oocyte count of more than 10. 3. participants who consent to undergoing ivf with intracytoplasmic sperm injection (icsi) and time-lapse embryo culture. exclusion criteria: 1. women diagnosed with untreated uterine abnormalities as assessed by a physician. 2. participants with a body mass index (bmi) outside the range of 18.5-30 kg/m\^2. 3. patients undergoing ivf using sperm retrieved through surgical extraction. 4. patients undergoing ivf using donated oocytes or donated sperm.
an observational study of mircera (methoxy polyethylene glycol-epoetin beta) in patients with chronic kidney disease in pre-dialysis or dialysis

Conditions: Anemia, Kidney Disease, Chronic

Summary: this prospective observational study will assess the efficacy and safety of mircera (methoxy polyethylene glycol-epoetin beta) in clinical practice in patients with chronic kidney disease, in pre-dialysis or on dialysis, initiated on mircera treatment. data from each patient will be collected over 12 months of treatment.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * chronic kidney disease, in pre-dialysis or dialysis * appropriate for treatment with mircera according to current guidelines and summary of product characteristics exclusion criteria: * anemia due to non-renal causes * pregnant or lactating women * uncontrolled hypertension * known hypersensitivity to methoxy polyethylene glycol-epoetin beta
fdg-pet/ct in the evaluation of patients with suspected cholecystitis

Conditions: Cholecystitis

Summary: this is a pilot study to investigate the ability of fluorodeoxyglucose-positron emission tomography (fdg-pet) and positron emission tomography-computed tomography (pet/ct) as a direct method of detecting infection and/or inflammation of the gallbladder.

hepatobiliary iminodiacetic acid (hida) scan scintigraphy is a nuclear medicine scan used to evaluate patients suspected of having acute cholecystitis (infection/inflammation of the gallbladder). because it is an indirect test that looks for obstruction of the cystic duct structure, there are many causes for a false-positive hida study. there is a need for a more sensitive and specific test that can accurately assess gallbladder infection and/or inflammation. the purpose of this study is to determine the effectiveness of fluorodeoxyglucose (fdg) as a direct means of detecting patients with acute cholecystitis. fdg is an imaging agent that has previously been shown to accumulate in areas of infection and/or inflammation. the location and intensity of fdg accumulation in the body can be detected with a camera system called a "positron emission tomography" (pet) camera. in theory, this test should be effective in detecting acute infection and/or inflammation of the gallbladder. consenting participants will receive injection of fdg one hour prior to the fdg-pet/ct examination. the participant will then be imaged using a pet/ct machine, which is a special camera system that is capable of performing both a pet and ct scan at the same time. a ct scan is an anatomical imaging test and, for this research study, will mainly be used to localize the area of 18fdg accumulation recorded by the pet scan. the examination will take approximately one hour.

Eligibility criteria:
inclusion criteria: * known or high suspicion of cholecystitis * highly likely to undergo cholecystectomy * positive hida study * age \>18 years old * provide written informed consent exclusion criteria: * highly unlikely to proceed to surgery or biopsy * received an investigational drug within the past 30 days * pregnant or lactating * decline to provide written informed consent

Keywords: cholecystitis fdg pet/ct hida scan
study to investigate safety, absorption, elimination, and drug effect of bay2327949 in participants with different renal function status

Conditions: Pharmacokinetics

Summary: bay2327949 is currently under clinical development for chronic kidney disease. the goal of this study is to learn more about how the body absorbs, distributes and excretes the study drug when taken once per mouth as 30mg tablet. an additional important goal of this study is to gain more information on how well the study drug is tolerated and its effect on the human body functions. the study will enroll healthy participants or patients with mild, moderate or severe reduced kidney functions matched for age, weight and gender. the results of this study will help researchers to select the best dosing of the study drug for future studies in patients.


Eligibility criteria:
inclusion criteria: * participant must be ≥18 years of age * the study enrolls healthy participants and participants at different stages of renal impairment (mild to severe renal impairment). * race: white * bmi (body mass index): above or equal 18.5 and below or equal 35 kg/m\*2 at the first screening visit. * male or female. * participants with renal impairment must have an egfr (estimated glomerular filtration rate) \ 10 days before dosing). stable renal function, e.g. a serum creatinine value determined at least 3 months before the pre-study visit should not vary by more than 25% from the serum creatinine value determined at the pre-study visit confirmed by nephrologist or general practitioner the patient is under care. exclusion criteria: * clinically relevant findings in the physical examination affecting the objectives of the study. * systemic use of the following co-medications from 2 weeks before administration until end of follow-up: * moderate and strong inhibitors of cyp3a; * moderate and strong cyp3a inducers; * moderate and strong inhibitors of p-gp transport; * udp-glucuronosyltransferase (ugt) inhibitors probenecid and valproic acid. * regular daily consumption of more than 10 cigarettes. * acute renal failure. * active nephritis. * impairment of any other major organ system other than the kidney. * change in chronic medications for renal disease (or its consequences) less than 4 weeks prior to dosing.
comparison of lymph drainage and connective tissue massage in fibromyalgia patients

Conditions: Fibromyalgia

Summary: the present study was designed to analyze and compare the effects of manual lymph drainage therapy and connective tissue massage in females with fibromyalgia (fm).

the lack of specific disease mechanisms is reflected in the fact that no cure has been found for the disease. thus, the many interventions which are advocated in fm are targeted against the more general characteristics of pain and disability. current pharmacological interventions have limited efficacy. there is an increasing consensus that therapy should also include non-pharmacological approaches. manual therapy techniques are composed of a variety of procedures directed at the musculoskeletal structures in the treatment of pain. two major subcategories exist that divide these techniques into those which produce joint motion and those which do not. the first subcategory includes manipulation, mobilization, and manual traction. the second subcategory involves both generalized soft tissue therapies, such as the many types of massage, and focal soft tissue therapy (10). consequently, there is currently no recognized effective treatment for fm patients. in addition, there is limited number of study dealing with the effect of manual therapy techniques on fm. although, there were some studies about manual lymph drainage therapy (mldt) and connective tissue massage (ctm) in fm. there wasn't found any study concerning the comparison of the effects of mldt and ctm. in this study, mldt and ctm were used for fm, which are included in the second subcategory of manual therapy techniques. based on positive results of some studies about mldt and ctm in fm, this study was planned to test and compare the effects of mldt and ctm in terms of pain, health status and hrqol in females with fm using a randomized control trial.

Eligibility criteria:
inclusion criteria: * female outpatients * being ≥ 25 years or older * being met the criteria for fm as defined by the american college of rheumatology * having pain with the onset at least 3 months before baseline visit * pain in the neck or shoulder region * have never been treated for fm * being volunteer for participating exclusion criteria: * pain from traumatic injury or structural or regional rheumatic disease, * chronic infection, * fever or an increased tendency to bleed, * severe physical impairment, * signs of tendinitis, * cardiopulmonary disorder, * inflammatory arthritis, * autoimmune disease, * uncontrolled endocrine disorder, * allergic disorder, * pregnancy or breast-feeding, * malignancy, * unstable medical or psychiatric illness or medication usage. * they were asked not to use antidepressant, myorelaxant, and non-steroid anti-inflammatory drugs during three days before the first appointment and the treatment sessions and the evaluation process after the treatment.

Keywords: fibromyalgia manual lymphatic drainage connective tissue massage pain health related quality of life randomized controlled trial
pharmacokinetics of enteral omeprazole suspension in patients with cerebral palsy and mental retardation

Conditions: Gastreoesophageal Reflux Disease

Summary: gastroesophageal reflux disease and reflux-esophagitis are a major chronic problem in most children with cerebral palsy and mental retardation. oral administration of enteric-coated formulations of the acid-labile proton pump inhibitor omeprazole is often problematic in these patients who may be suffering from swallowing disorders. a suspension of omeprazole in a sodium bicarbonate solution is often used for administration via the gastrostomy tube. this trial aims to compare the pharmacokinetics of omeprazole administered through the gastrostomy tube as a suspension in pediatric patients with cerebral palsy and mental retardation versus the pharmacokinetics of omeprazole administered as a multi-unit-pellet system (mups®). the crossover study will consist of 2 consecutive treatment periods of 14 days.


Eligibility criteria:
inclusion criteria: * children \> 15 kg * cerebral palsy and mental retardation with swallowing disorders * presence of gastrostomy tube * gerd and/or reflux-esophagitis treated with omeprazole at the same dose since at least 2 weeks * informed consent exclusion criteria: * treatment with ciclosporine, tacrolimus, mycofenolate * treatment with anticoagulants * infection * recent start of treatment with known inhibitors of the omeprazole-metabolism * moderate to severe hepatic impairment (sgpt and/or ast \> 3 times upper limit)
genetic testing of monogenic hypertension in chinese population

Conditions: Monogenic Hypertension

Summary: monogenic hypertension, which follows the rules of mendel's genetic law, is one of the most important causes of hypertension. generally, patients occur hypertension in early age, have family history, and often manifest severe hypertension or refractory hypertension. at present, only a few hypertension centers of hospitals in china will help clinically difficult diagnosis hypertensive patients to test some selective genes, while most of other hospitals still perform diagnosis based on biochemical examination and clinical symptoms. therefore, in order to provide better guidance for the diagnosis and treatment for hypertensive patients, this project aims to develop a single gene detection panel for genetic hypertension, so as to provide new diagnostic technology for early intervention, prevention and treatment of hypertension in clinics.


Eligibility criteria:
inclusion criteria: * hypertension patients meet one of the following criteria 1. beginning age of hypertension: \<35 years (regardless of family history of hypertension); 2. refractory hypertension (blood pressure is difficult to control): triple antihypertensive drugs treatment for 1 months, 3 times of non-continuous high blood pressure in consulting room (sbp ≥140mmhg and/or dbp≥90mmhg); * patients suspected of secondary hypertension, meeting one of the following criteria 1. pheochromocytoma or cushing syndrome; 2. hypertension with hypokalemia; 3. hypertension with hyperkalemia; 4. hypertension with special body shape, such as central obesity, moon face, acne etc.. 5. adrenal tumor; exclusion criteria: * renal parenchymal / renovascular hypertension * patients exceed age of 50, and with coronary heart disease and arteriosclerosis

Keywords: genetic testing chinese population
self reduction of shoulder dislocation

Conditions: Anterior Shoulder Dislocation

Summary: anterior dislocation of the shoulder (glenohumeral joint) is one of the most prevalent dislocations. following a first dislocation recurrence rates of up to 80% have been reported. many patients will seek medical assistance for reduction of the shoulder after each of these recurrent dislocations. the investigators describe the results of reduction of anterior glenohumeral dislocation using a modified self manipulated milch technique that can be performed by the patients themselves after simple guidance and demonstration. this method is directed to patients who are not willing or cannot have surgical stabilization and may be in a place where medical assistance is not available.


Eligibility criteria:
inclusion criteria: * anterior shoulder dislocation * acute (24 hours) shoulder dislocation exclusion criteria: * shoulder fracture * non-cooperative patient
fulvestrant for the treatment of recurrent or metastatic endometrial carcinoma.

Conditions: Endometrial Carcinoma

Summary: the purpose of this study is to determine the efficacy of a monthly administration of fulvestrant in patients with recurrent or metastatic endometrial carcinoma by assessment of the clinical tumour response after 3 injections.


Eligibility criteria:
inclusion criteria: * histologically confirmed, recurrent or metastatic endometrial carcinoma * postmenopausal * hormonreceptor positive exclusion criteria: * pre-treatment with fulvestrant * previous endocrine therapy of the endometrial carcinoma * previous malignancy less than 3 years ago other than in situ carcinoma of the cervix, basal cell carcinoma or squamous carcinoma of the skin

Keywords: recurrent or metastatic endometrial carcinoma
exercise performance in patients with atrial fibrillation

Conditions: Atrial Fibrillation

Summary: heart failure and stroke are the two major complication of atrial fibrillation. current treatment for atrial fibrillation is so focused to stroke prevention, but the risk assessment for heart failure is less highlighted. the most of patients with atrial fibrillation have cardiac functional limitation of variable degree. we hypothesize that the exercise test would reveal the subclinical cardiac dysfunction, and might be helpful to classify the patients with atrial fibrillation according to their exercise capacity real cardiac function.


Eligibility criteria:
inclusion criteria: * nonvalvular chronic atrial fibrillation * left ventricular ejection fraction \>40% exclusion criteria: * acute decompensated heart failure within 30 days * unstable hemodynamic status * significant coronary artery disease * any condition interfering sufficient exercise * valvular stenosis or regurgitation of moderate or severe degree * obstructive or restrictive lung disease of moderate or severe degree * active malignancy