Kornimate/medical-research-clean huggingface dataset:
reducing uv exposure to prevent skin cancer: message development & testing

Conditions: Behavior, Health

Summary: phase 3b of the research will be a laboratory experiment that uses an experimental and analytic design that is parallel to that used in phase 3a, the online experiment. the primary objective of phase 3b is to assess physiological response (i.e., eye tracking) to different message appeals of the audio-visual messages used in phase 3a on respondents' behavioral intentions and uv-related behavioral choices post-exposure. including time for preparation, viewing, and removal of the monitoring equipment, the message viewing session will take about 45 minutes per session.


Eligibility criteria:
inclusion criteria: * 18-49 year old non-hispanic white (nhw) adults * or 18-25 year old nhw females who have tanned indoors in the past 12 months exclusion criteria: -
autogenic drainage effect on blood gases and prevention of pulmonary complication after upper abdominal surgery

Conditions: Postoperative Complications

Summary: purpose: this study will find out the effect of autogenic drainage on the prevention of pulmonary complications after upper abdominal surgery. method: sixty patients post upper abdominal surgeries will be included, their ages ranged from 50 to 60 years old. the patients will be divided into two groups, study group (a) include patients that receive first traditional physiotherapy (localized breathing exercise, diaphragmatic breathing, and splinted coughing) then autogenic drainage (b)-group b: patients that receive traditional physiotherapy (localized breathing exercise, diaphragmatic breathing and splinted coughing)

purpose: this study will find out the effect of autogenic drainage on the prevention of pulmonary complications after upper abdominal surgery. method: sixty patients post upper abdominal surgeries will be included, their ages ranged from 50 to 60 years old. the patients will be divided into two groups, study group (a) include patients that receive first traditional physiotherapy (localized breathing exercise, diaphragmatic breathing, and splinted coughing) then autogenic drainage (b)-group b: patients that receive traditional physiotherapy (deep breathing exercise, diaphragmatic breathing and splinted coughing)

Eligibility criteria:
inclusion criteria: * age from 50 to 60 years * patients undergoing elective upper abdominal surgery with an abdominal incision longer than 5 cm that is above or extending above the umbilicus. * non-smoker patients exclusion criteria: * patients developing cancer * patients with rib fractures * inability to comprehend and follow instructions. * pre-existing obstructive sleep apnea * current hospital patient for a separate episode of care. * patients requiring esophageal surgery or organ transplant.

Keywords: autogenic drainage blood gases pneumonia, upper abdominal surgery postoperative pulmonary complications
observational study in patients with functional benign prostatic hyperplasia symptoms who switched from phytotherapy to alna® (tamsulosin)

Conditions: Prostatic Hyperplasia

Summary: the objective of the observational study were to investigate the switch from phytotherapy to alna® after at least 4 weeks of phytotherapy and still presented with a symptom sum score of ≥ 8 points (international prostate symptom score (ipss))


Eligibility criteria:
inclusion criteria: * patients suffering from bph symptoms * preceding treatment with a phytotherapeutic for at least 4 weeks * ipss sum score ≥ 8 points prior to treatment start with alna® * indication for a switch to treatment with alna® for a minimum period of 2 months exclusion criteria: * patients fulfilling one of the general or specific contraindications listed in the alna® summary of product characteristic, particularly patients with known hypersensitivities against tamsulosin hydrochloride or any other ingredient of the product, orthostatic dysregulation or severe liver insufficiency * patients receiving alna® within the 4 weeks prior to the start of the present observational study
cryobiopsy study to assess drug distribution in subjects with suspected interstitial lung disease

Conditions: Lung Diseases, Interstitial

Summary: interstitial lung disease (ild) often affects distal lung, and the evaluation of drug distribution to the relevant lung compartments is essential for development of new treatment options. this single center study will utilize samples obtained by transbronchial cryobiopsy (tbcb) procedure to assess the distribution of inhaled drugs in the lungs of the subjects with fibrotic lung disease using mass spectrometry techniques. the study will have a single visit and will include approximately 20 adult subjects with suspected fibrotic ild and requiring tbcb as part of their diagnostic assessment. this will provide tbcb samples from up to 20 subjects, up to 5 of whom may also provide endobronchial forceps biopsy samples. the study will have 3 phases including screening to check the eligibility, biopsy phase in which all subjects will receive nebulized ipratropium bromide 500 microgram (mcg) for 10 minutes immediately before undergoing bronchoscopy and follow up phase from 7 to 14 days after the procedure. drug distribution in the lung will be assessed by analyzing biopsy samples collected using mass spectrometry and imaging techniques.


Eligibility criteria:
inclusion criteria: * 18 and above years of age inclusive, at the time of signing the informed consent. * subjects with suspected ild listed for tbcb for clinical reasons following review by the ild services at university college london hospitals (uclh) in whom diagnosis has remained unclear following radiological and clinical assessment. * a subject with a clinical abnormality or laboratory parameter(s) which is/are not specifically listed in the inclusion or exclusion criteria, outside the reference range for the population being studied, may be included only if the investigator in consultation with the medical monitor agree and document that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures. * male or female. * capable of giving signed informed consent which includes compliance with the requirements and restrictions. exclusion criteria: * subjects who have a known drug allergy or other contra-indication to ipratropium bromide. * known hypersensitivity to atropine or ipratropium bromide or any other known drug allergies that, in the opinion of the investigator or glaxosmithkline (gsk) medical monitor, contraindicates their participation. * as a result of the medical history, physical examination or screening investigations, the physician responsible considers the subject unfit for the study. * the subject is unable or unwilling to perform study assessments and procedures correctly. * subjects with a recognized co-existing respiratory disorder (other than ild) that in the opinion of the investigator would confound the study outcomes.

Keywords: ipratropium bromide cryobiopsy tbcb ipf transbronchial cryobiopsy interstitial lung disease
osteopathic manipulative treatment versus therapeutic exercises in subjects with chronic non-specific low back pain

Conditions: Low Back Pain

Summary: this study evaluates the effectiveness of treatment osteopathic manipulation in the treatment of subjects with chronic nonspecific low back pain.


Eligibility criteria:
inclusion criteria: * subjects with constant or intermittent low back pain with intensity greater than 30 mm visual analog scale (vas) for at least three months duration, with a diagnosis of chronic low back pain exclusion criteria: * subjects who have spine fractures, * dislocations * ligament ruptures * muscle ruptures * skin lacerations * sacroiliitis * vertebral osteomyelitis * infection * disc herniations with radicular symptoms * rheumatic disorders * cauda equina syndrome * tumors * referred pain visceral * red flags * lower limb discrepancy greater than 2 cm * several conditions requiring participants to be absent for more than two weeks of activities in the experiment * positioning itself as not volunteer the same.

Keywords: osteopathic manipulative treatment chronic nonspecific low back pain low back pain
positron emission tomography (pet) study with (11c)flumazenil to determine central gabaa receptor occupancy of azd7325

Conditions: Anxiety

Summary: the study is carried out in order to determine the relationship between the dose of azd7325 and the blood concentration of azd7325, and to investigate to which extent azd7325 binds to the gabaa receptors.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) of 18-30 kg/m2 and weight of 60-100 kg * clinically normal physical findings, medical history and laboratory values. exclusion criteria: * clinically significant illness or clinical relevant trauma within 2 weeks before the study start. * intake of another investigational drug or participation in a clinical study the past 12 weeks. * previous participation in a pet study within the past 12 months. suffer from claustrophobia and would be unable to undergo mri (magnetic resonance imaging) or pet scanning.

Keywords: anxiety gaba receptors positron emission tomography pet phase i
mild anh on pre-bypass coagulation function during cardiac surgery

Conditions: Mitral Regurgitation; Mitral Stenosis; Tricuspid Regurgitation

Summary: the impact of acute normovolemic hemodilution (anh) using hydroxyethyl starch before initiating cardiopulmonary bypass (cpb) on whole blood viscoelastic profile after cpb has not been well established. patients undergoing cardiac surgery employing moderate hypothermic cpb are randomly allocated into one of two groups: in group-anh, anh is applied by using a balanced hydroxyethyl starch (hes 130/0.6); and in group-c, anh is not applied. after weaning from cpb, intergroup differences of intem, extem, fibtem, and aptem profiles are analyzed. as a primary outcome, the inter-group differences between maximal clot firmness of extem will be determined at 10 min after anh in group-anh and that at control.

background: the impact of acute normovolemic hemodilution (anh) using hydroxyethyl starch before initiating cardiopulmonary bypass (cpb) on whole blood viscoelastic profile after cpb has not been well established. method: patients undergoing cardiac surgery employing moderate hypothermic cpb are randomly allocated into one of two groups: in group-anh(n=29), anh is applied by using a balanced hydroxyethyl starch (hes 130/0.6); and in group-c anh (n=29)is not applied. intergroup differences of intem, extem, fibtem, and aptem profiles are analyzed. after anesthesia induction (control) and after weaning from cpb and protamine neutralization (after-cpb) in both groups. in group-anh, those are determined after anh (after-anh). as a primary outcome, the inter-group difference between maximal clot firmness of extem is determined at 10 min after anh in group-anh and that at control. as secondary outcomes, intergroup differences of hematocrit (hct), na+, k+, hco3-, ca2+, osmolarity, and s-cr are determined intergroup differences of data at t2 are performed.

Eligibility criteria:
inclusion criteria: * patients undergoing cardiac surgery with cardiopulmonary bypass who signed written informed consent exclusion criteria: * preoperative renal failure requiring reran replacement therapy * preoperative liver disease * preoperative low cardiac output (ef \< 50%) * preoperative iabp application, atrial fibrillation, pacemaker * contraindication for applying tee * intraoperative withdrawal

Keywords: rotational thromboelastometry cardiac surgery acute normovolemic hemodilution hemodilution coagulation
observational registry on patients with endogenous cs to document safety and effectiveness of ketoconazole.

Conditions: Cushing Syndrome

Summary: this is a non-interventional, prospective, multinational, multicentre, observational study, in which data collected are those derived from routine clinical practice via an european registry on cs: ercusyn.

the aim is to further document the safety and efficacy of ketoconazole hra administered in routine clinical practice in patients with cs. the study operates under real clinical practice conditions, i.e. there is no treatment protocol thus.

Eligibility criteria:
inclusion criteria: 1. male or female patients aged from 12 years or older with a diagnosis of cs 2. patients who started ketoconazole therapy after study start 3. for patients previously treated with ketoconazole, patients must have taken their last dose at least 6 months before starting ketoconazole again in this study. 4. written informed consent signed prior to registration of any patient data in hra modules. exclusion criteria: 1. adrenal cortical carcinoma 2. patients currently participating in any other trial (interventional or not) of an investigational medicine or participation in the past one month before start of ketoconazole 3. patients who have at least one contraindication among those listed in section 4.3 of the ketoconazole smpc
borrelia species in cutaneous lyme borreliosis

Conditions: Lyme Borreliosis

Summary: the aim of this study is to identify the species of borrelia involved in the dermatologic manifestations of lyme borreliosis in france. indeed, in europe, as opposed to north america, many bacterial species are involved in lyme borreliosis. yet, very few is known about the prevalence and distribution of different bacteriological species that account for the disease in france. thus, this a nation-wide study in which all french dermatologists are invited to participate. every adult patient presenting with one of the cutaneous manifestation of lyme borreliosis: erythema migrans, lymphocytoma or acrodermatitis chronica atrophicans can be included in the study. if the patient agrees participating, after information and written consent, a cutaneous biopsy will be performed in order to isolate borrelia by means of culture and pcr. an estimated 400 biopsies should be performed within 2 years.


Eligibility criteria:
inclusion criteria: * informed adult patient who signed written consent with one the following conditions: * erythema migrans * borrelial lymphocytoma * acrodermatitis chronica atrophicans exclusion criteria: * pregnancy or lactation * allergy to local anesthesia * patient who refuses biopsy

Keywords: lyme borreliosis erythema migrans borrelial lymphocytoma acrodermatitis chronica atrophicans borrelia burgdorferi borrelia afzelii borrelia garinii
feasibility study: lifting and tightening of the elbows

Conditions: Skin Laxity

Summary: up to 20 subjects will be treated. treated subjects will receive one ulthera® treatment on the elbows. follow-up visits will occur at 90 and 180 days post-treatment. study images will be obtained pre-treatment, immediately post-treatment, and at each follow-up visit.

this is a prospective, single-center, pilot clinical trial to evaluate the efficacy of the ulthera® system to improve skin laxity above the elbows. masked assessment of pre- and post-treatment photos will be performed. global aesthetic improvement scale scores and patient satisfaction questionnaires will also be obtained.

Eligibility criteria:
inclusion criteria: * male or female, age 21 to 65 years. * subject in good health. * mild to moderate skin laxity on the elbows. * understands and accepts the obligation not to undergo any other procedures in the areas to be treated through the follow-up period. * willingness and ability to comply with protocol requirements, including returning for follow-up visits and abstaining from exclusionary procedures for the duration of the study. * subjects of childbearing potential must have a negative urine pregnancy test result and must not be lactating at visit 1 and be willing and able to use an acceptable method of birth control exclusion criteria: * presence of an active systemic or local skin disease that may affect wound healing. * excessive subcutaneous fat around the elbows. * excessive skin laxity around the elbows. * significant scarring in areas to be treated. * significant open wounds or lesions in the area to be treated

Keywords: ulthera® system ultherapy™ treatment ulthera, inc. ultrasound treatment for skin tightening
gastric insufflation during positive pressure ventilation

Conditions: Gastric Insufflation

Summary: effect of peak inspiratory pressure on the gastric insufflation is evaluated using ultrasonography during face mask ventilation in obese adults. effect of facial mask holding techniques on the gastric insufflation is also evaluated.


Eligibility criteria:
inclusion criteria: * patients with body mass index ≥ 30 kg/m2 who are scheduled for general anesthesia exclusion criteria: * risk of delayed gastric emptying or gastroesophageal reflux (gastroesophageal reflux disease, achalasia, history of stomach surgery, gastrointestinal obstruction, uncontrolled dm) * pregnancy * known or predicted difficult airway
motor outcomes to validate evaluations in pediatric fshd (move peds)

Conditions: Muscular Dystrophy, Facioscapulohumeral

Summary: the primary goal of this study is to validate motor and functional outcomes and refine clinical trial strategies for pediatric-onset fshd

move peds is a prospective 2-year study recruiting eighty pediatric participants to accelerate therapeutic development for pediatric-onset fshd. the study aims to validate outcomes and refine clinical trial strategies. previous cross-sectional studies suggest that younger age of onset is linked to greater clinical severity and that having 1-3 d4z4 repeats is associated with extra-muscular complications in pediatric fshd. prospective studies in early-onset fshd have been limited by the small number of sites and low recruitment and follow-up rates. early-onset pediatric fshd is of high interest to drug companies because: 1. it results in a more significant disease burden than in adults. 2. treating fshd at earlier ages may have a more lasting and profound effect. 3. genetic, molecular, and clinical factors may differ between pediatric and adult-onset fshd. 4. smaller body size and faster progression rates may make aav-delivered gene therapies more feasible. the fshd ctrn's previous research showed that the fshd composite functional measure (fshd-com), reachable workspace (rws), and quantitative mri measures (qmri) are responsive to disease progression or treatment in adults with fshd and correlate with performance. investigators hypothesize that early changes in qmri in pediatric subjects will predict 2-year changes in fshd-com peds or rws.

Eligibility criteria:
inclusion criteria: * age 5-17 years. * genetically confirmed fshd (types 1 or 2). * symptomatic weakness (facial, shoulder, core, or limb weakness) * able to complete a 10-meter walk without the support of another person in less than 12 seconds (canes, walking sticks, and braces allowed; no walker). in order to include early onset participants up to 8 individuals will be entered with baseline 10mwr \> 12 seconds or who are no longer ambulatory (≤10%) exclusion criteria: * unwilling or unable to provide informed consent or assent. any other medical condition which in the opinion of the investigator would interfere with study participation. * malignancy with ongoing treatment with chemotherapeutic agents or anabolic agents * use of immunosuppressants including prednisone or performance enhancing drugs including testosterone within 6 months * pregnancy * recent or ongoing infection * presence of contraindication to performance of mri: pacemaker, metallic foreign body in eye, brain aneurysm clip (unless documented as mri compatible) * in the opinion of the investigator unable to follow directions for standardized testing * note: not being able to complete mri will not result in a screen failure. if subject is not able to complete the procedure due to fear or anxiety, they will have the opportunity to try again at later visits. however, subject must be willing to attempt to perform the mri to meet inclusion/exclusion criteria

Keywords: fshd pediatric
perioperative warming measures in cesarean delivery

Conditions: Hypothermia; Anesthesia; Hypothermia, Newborn; Hypothermia, Sequela

Summary: the purpose of this study is to evaluate the best method for keeping patients warm during cesarean deliveries and the effect of temperature change on the patient and baby


Eligibility criteria:
inclusion criteria: * scheduled for elective cesarean section under neuraxial anesthesia * singleton pregnancy exclusion criteria: * gestational age of less than 37 week * emergency cesarean
youth substance use prevention/reduction through science-based drug abuse education

Conditions: Substance Abuse

Summary: our primary goal is to conduct a pilot study of the effects of a new potential strategy for youth substance abuse prevention - science-based drug education integrated into the high school science curriculum. through this pilot study we propose to: (1) demonstrate that this new strategy shows promise, and (2) estimate the effect size for the intervention.

nida, in recent years, has put resources into summarizing and synthesizing cutting-edge medical and basic science research discoveries about the short-term and long-term effects of drug use on the developing brain. one outcome of this results was the production of a science-based drug education program entitled "the brain: understanding neurobiology through the study of addiction." this is a 5-lesson module for high school science classes that teaches about brain structure and function, how drugs affect and change the biology and chemistry of the brain, how addiction occurs in the brain, and that addiction is a chronic, recurring disease. however, the effect of receipt of this program on students' substance use knowledge, attitudes, perceived risk of harm, and behavior has not been systematically evaluated to date. the specific aims of this project are: 1. to evaluate the effects of receipt of the curriculum on specific cognitive contributors to substance use including a)students' knowledge about the short- and long-term effects of substance use on the brain; b)perceived risk of harm from substance use; and c)intention to use substances in the next 3 months. 2. to evaluate the effects of the intervention on actual substance use behavior. we hypothesize that the effectiveness of this approach may be modified by the students' level of prior and current substance use, with the effect being stronger among those who have not already initiated use, or among those who have very low use. therefore, we will specifically examine whether the intervention a)prevents substance use initiation among students who had no previous use, b)stops use among students with low lifetime use, and c) reduces use among those with higher levels of use.

Eligibility criteria:
inclusion criteria: * student in 9th/10th/11th grade science classes at fenway high school at start of study or student in 11th grade science classes at boston arts academy at start of study * parental permission to participate exclusion criteria: * no parental permission to participate * unable to read english

Keywords: substance abuse