Kornimate/medical-research-clean huggingface dataset:
comprehensive awareness and control in diabetes patients in china jiangxi: a cross-sectional survey

Conditions: To Assess the Level of Control of Blood Glucose, Blood Pressure, and Blood Lipids Among Patients With Type 2 Diabetes in Jiangxi Province

Summary: the study is a multicenter, sub-center contrast, cross-sectional survey.the primary objective of this study was to assess the comprehensive awareness and control of blood glucose, blood pressure, and blood lipids among patients with type 2 diabetes in china jiangxi. an additional objective was to investigate the impact of hospital type on clinical outcomes.

background: with the continuous improvement of living standards in the past 30 years, the lifestyle and diet of chinese people have undergone significant changes, leading to a significant increase in the prevalence of diabetes, hypertension and lipid metabolism disorders. prevention and control work is also increasingly valued. at present, there is no research on the awareness rates and control rates of blood glucose, blood pressure and blood lipids in diabetic patients in jiangxi province. during the 13th five-year plan period, the country has vigorously promoted the grading system of chronic non-communicable diseases, but there is a big gap between the levels of disease management in different levels of hospitals. methods:the province's multi-center, sub-center control, cross-sectional survey, the number of cases planned to be included in 10000 cases. patient access: within 2 years from the date of the study (december 2016), eligible patients were screened out of outpatients in the participating hospitals, and patients were reviewed and informed of the informed consent.inclusion criteria: in line with the who1999 diabetes diagnostic criteria; age 20-80 years; duration of 1 year or more; signed informed consent. exclusion criteria: at the same time using other experimental drugs or in other clinical trials; gestational diabetes, other special types of diabetes; in acute infection, trauma and other stress conditions and the acute phase of the disease and other anomalies; patients with malignant tumors.

Eligibility criteria:
inclusion criteria: * patients aged 20 years to 80 years who were diagnosed with diabetes according to the world health organization criteria, at least 1 years before screening,written informed consent exclusion criteria: * patients if they were pregnant or other special types of diabetes, patients with malignant tumor,participating in any other clinical studies, in phase of acute infection, trauma, such as stress state and acute phase of disease and other anomalies
a randomized pilot/pharmacodynamic/genomic study of neoadjuvant paricalcitol to target the microenvironment in resectable pancreatic cancer

Conditions: Adenocarcinoma of the Pancreas

Summary: this study is a randomized pilot/pharmacodynamic/genomic study of neoadjuvant paricalcitol to target the microenvironment in resectable pancreatic cancer to determine the effect of targeting the vitamin d metabolic program in the tumors of patients treated with one cycle of gemcitabine/abraxane with or without paricalcitol prior to surgery for resectable pancreatic cancer through an assessment of cellular and imaging markers.

this study is a randomized pilot/pharmacodynamic/genomic study of neoadjuvant paricalcitol to target the microenvironment in resectable pancreatic cancer to determine the effect of targeting the vitamin d metabolic program in the tumors of patients treated with one cycle of gemcitabine/abraxane with or without paricalcitol prior to surgery for resectable pancreatic cancer through an assessment of cellular and imaging markers.

Eligibility criteria:
inclusion criteria * previously untreated, apparently resectable, adenocarcinoma of the pancreas at registration. * age greater than or equal to 18 years * eastern cooperative oncology group performance status of 0-2. * standard laboratory criteria for hematologic, biochemical, and urinary indices within a range that, in the opinion of the physician, clinically supports enrollment of the patient on the trial. note: subjects must have: creatinine \ 1.5x109/l, and platelets \>100,000/mm3 * ability to provide written informed consent exclusion criteria * patients with hypercalcemia (blood levels greater than 11.5 mg/dl; in patients with kidney disease, blood calcium levels must be 9.5 mg/dl or lower before starting paricalcitol). * patients who are currently pregnant, planning to become pregnant, or breast-feeding. * patients who, in the opinion of the physician, would not be clinically appropriate for receipt of the therapy regimen associated with participation
applying a chatbot to geriatric patients in psychiatric clinics: a pilot study

Conditions: Loneliness; Geriatric Depression

Summary: this study will use the caring chatbot developed by the taipei university of technology team to provide care for participants and use robots to talk to them to collect daily changes in mood, sleep, and activities, and analyze the factors that affect the physical and mental health of the elderly.

the prevalence of anxiety and depression in middle-aged and elderly people is quite high. among the risk factors for illness, "loneliness" is closely related to the physical and mental health of the elderly: the higher the loneliness of the elderly, the more likely to develop unhealthy lifestyle habits and emotional symptoms such as depression and anxiety. depression and anxiety are often comorbid, and the diagnoses of the two groups have many symptoms that overlap each other. emotional symptoms that have not been effectively treated have a great impact on the quality of life, and the drug treatment of emotional disorders in the elderly is more difficult. in addition to medication, maintaining a healthy lifestyle is also conducive to the control of emotional disorders. information technology has been used in supplementary medical care and maintenance of physical and mental health for decades. however, reviewing the literature, there is less research on applications developed in cooperation between the information field and the field of psychiatric medical care, and there are no applications developed for the mental health of middle-aged and elderly people. this study will use the caring chatbot developed by the national taipei university of technology team to provide care for the participants enrolled from the psychiatric outpatient department, and use the chatbot to talk to them to collect daily changes in mood, sleep, and activities, and analyze the factors that affect the mental health of the elderly. this research anticipates the following goals: 1. with the chatbot developed, it provides care for subjects every day and collects their daily changes in mood, sleep, and activities. 2. analyze the relationship between robot interaction and emotional changes, and evaluate the impact of chatbot intervention on the health behavior of the case.

Eligibility criteria:
inclusion criteria: * with the diagnosis of persistent depressive disorder, major depressive disorder, general anxiety disorder, panic disorder, or agoraphobia * the condition of their disease is relatively stable (defined as no thought of death and no medication adjustment in the recent 3 months). * have a personal mobile phone or communicator that can connect to the internet exclusion criteria: * those who are unwilling to participate in this research * those who have poor assessment ability by clinicians and cannot understand the content of the questionnaire; or those who cannot continue to complete the test due to their physical condition * comorbid schizophrenia or bipolar disorder * patients with dementia, brain injury, substance abuse, and stroke

Keywords: geriatric psychiatry chatbot conversational agent
hypofractionated sbrt for prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this study is to determine, in both low-risk and intermediate-risk cohorts, the rates of acute and late grade 3 or higher gastrointestinal and genitourinary toxicity observed during a 24 month follow up and to estimate the rate of biochemical disease-free survival, phoenix and american society for therapeutic radiology and oncology definitions, at 2 years following hypofractionated stereotactic body radiation therapy for low and intermediate risk prostate cancer.

radiosurgery should be ideal for treating prostate cancer because: * targeting accuracy for static targets is excellent, with an error of about 1mm, * it can adjust for intra-fractional organ motion, reducing the volume of the target ptv and therefore the dose to surrounding organs, * by using over one-hundred non-conplanar beams, the dose gradient between the prostate and surrounding tissues may be superior to that achieved with conventional linear accelerators, * the radiobiology of prostate cancer may favor large dose per fractions.

Eligibility criteria:
inclusion criteria: * histologically proven prostate adenocarcinoma * gleason score 2-7 * biopsy within one year of date of registration * clinical stage t1b-t2b, n0-nx, m0-mx (ajcc 6th edition) * t-stage and n-stage determined by physical exam and available imaging studies (ultrasound, ct, and/or mri) * m-stage determined by physical exam, ct or mri. bone scan not required unless clinical findings suggest possible osseous metastases. * psa ≤ 20 ng/dl * patients belonging in one of the following risk groups: * low: cs t1b-t2a and gleason 2-6 and psa ≤ 10, or * intermediate: cs t2b and gleason 2-6 and psa ≤ 10, or cs t1b-t2b, and gleason 2-6 and psa ≤ 20 ng/dl, or gleason 7 and psa ≤ 10 ng/dl * prostate volume: ≤ 100 cc * determined using: volume = π/6 x length x height x width * measurement from ct or ultrasound ≤90 days prior to registration. * ecog performance status 0-1 * completion of patient questionnaires:fact-g questionnaire, aua questionnaire, epic-26 questionnaire, shim questionnaire, utilization of sexual medications/devices questionnaire * consent signed. exclusion criteria: * prior prostatectomy or cryotherapy of the prostate * prior radiotherapy to the prostate or lower pelvis * implanted hardware or other material that would prohibit appropriate treatment planning or treatment delivery, in the investigator's opinion. * chemotherapy for a malignancy in the last 5 years. * history of an invasive malignancy (other than this prostate cancer, or basal or squamous skin cancers) in the last 5 years. * hormone ablation for two months prior to enrollment, or during treat

Keywords: prostate stereotactic radiosurgery
elderly demented patients: aromatherapy complementary to psychopharmacotherapy psychological disorders and bpsd behavior

Conditions: BPSD (Behavioral and Psycological Symptoms of Dementia)

Summary: behavioral and psycological symptoms of dementia, (bpsd) are one of the major problem for families, doctors and for patients the same. to reduce the side effects of the standard treatments, is important to find an alternative methods of treatment, eg the aromatherapy. there is an incresing in scientific evidence the its use in dementia behavior related.

behavioral and psycological symptoms of dementia, (bpsd) are one of the major problem for families, doctors and for patients the same. in absence of the universally recognized guidelines, the standard treatment involves the use of psychotropic drugs (typical / atypical neuroleptics, antidepressants, benzodiazepines) that are often not very effective and involve a series of side effects such as sedation, slowing down -motor with impaired cognitive performance, cardiac electrical changes and extrapyramidal syndrome. in view of this, it is important to find an alternative methods of treatment, which can reduce psychological and behavioral disorders and at the same time the use of psychotropic drugs. as for aromatherapy, ie the therapeutic use of natural essential oils, there is a decades-long clinical experience, especially in france, which is accompanied by increasing scientific evidence with considerable increase in publications in its use in psychological disorders and dementia behavior related. based on the scientific publications available, it was therefore decided to use two essential oils (citrus sinensis, lavandula angustifolia) in environmental diffusion in the geriatric department of the clinica luganese moncucco.

Eligibility criteria:
inclusion criteria: * patients admitted to the acute geriatric ward; * patients with a known diagnosis of dementia associated with bpsd or diagnosis performed during hospitalization. exclusion criteria: * patients with alcohol-based dementia; * patients with mild cognitive impairment (mci) - section 4 -; * patients with language barrier; * patients already being treated with aromatherapy.

Keywords: bpsd (behavioral and psycological symptoms of dementia) aromatherapy elderly
the impact of resistance training on type 2 diabetes patients.

Conditions: Diabetes

Summary: the purpose of this study is to determine whether the long-term effects of high-intensity progressive resistance training could improve glucose and lipid metabolism in chinese type 2 diabetes.


Eligibility criteria:
inclusion criteria: * established type 2 diabetes exclusion criteria: * severe joint cardiovascular and respiratory system disease, uncontrolled hypertension (160/90 mmhg), severe diabetic nephropathy and neuropathy * with severe liver and kidney dysfunction * with mental system disease * pregnant women or nursing mothers
serum antimullerian hormone levels among epileptic patients

Conditions: Epilepsy; Reproductive Issues

Summary: the production of amh starts in granulosa cells before birth and the levels within the serum decreases towards the menapouse. the levels of amh do not change throughout the menstruation cycle hovewer, it can be affected in cases related to body mass index (bmi), polycyctic ovarian syndrome (pcos). the lower levels of amh had been documented after ovarian surgery, radiotheraphy and chemotheraphy. amh is a member of transforming growth faktor β (tgf- β ) and it has receptors in brain structures including hyppocammpus. it is highly active neurophysiologically and it has a protective effect against n-methyl-d -aspartate related neuronal injury that is demonstrated both in vivo and in vitro studies. as a result, being a neuroactive hormone; amh may have an effect on seizures within epileptic patients or serum amh levels may be effected in epileptic patients when compared with healthy ones.


Eligibility criteria:
inclusion criteria: * healthy and epileptic volunteer females * ages between 12-18 * after menarche exclusion criteria: * ovarian surgery, * history of radiotherapy * history of chemotherapy, * before menarche

Keywords: anti-mullerian hormone epilepsy adolescent
comparative study of laparoscopic combined trans-vesical and extravesical versus laparoscopic extravesical fistula excision in uterovesical fistula repair: a retrospective observational study

Conditions: Success of Operation

Summary: • the aim of this study is to compare between laparoscopic combined trans-vesical and extravesical versus laparoscopic extravesical fistula excision in uterovesical fistula repair.


Eligibility criteria:
inclusion criteria: patients diagnosed with uterovesical fistula with history of uterine cesarean section or any urogenital surgery complaining of amenorrhea, cyclic hematuria, with or without urinary incontinence. exclusion criteria: * • pregnant females. * patients who refuse to participate in the study. * patients with concomitant pathology that could affect symptoms e.g., polycystic ovary disease, stress incontinence, bladder cancer or overactive bladder. * patients with malignant fistula.
low-volume interval training and resistance exercise in individual with stroke

Conditions: Stroke

Summary: to examine the feasibility of low-volume interval training (lv-itt) and resistance exercise (re) on walking performance (walking endurance, gait speed, functional balance), lower limb muscle strength and quality of life among individuals with post-stroke.

prescribing aerobic and resistance training in concurrence is proposed as an optimum strategy to target cardiovascular as well as musculoskeletal functions in individuals with post-stroke. lower limb's resistance training alone in chronic stroke produces a large effect on muscle strength. however, it has shown uncertainty results on walking performance. therefore, it is suggested that to prescribe mix training (treadmill training and strength training) in order to improve muscle strength, gait performance and quality of life in stroke survivors. previous studies have shown the effect of mixed training on walking performance and endurance in other populations such as multiple sclerosis and coronary artery disease. however, there is a lack of study that conducted mixed training among chronic post-stroke. therefore, the feasibility study on the effectiveness of combining lv-itt and re in post-stroke should be conducted.

Eligibility criteria:
inclusion criteria: * age range between 45-65 years' old * at least 3-months post-stroke * gait speed ≤1.0 m·s -¹ measured by the 10 m walk test. * able to walk 10 m overground with assistive devices as needed and no physical assistance. * able to walk for 3 min on the treadmill at ≥0.17 m·s -¹ (0.4 mph) with no aerobic exercise contraindications. * modified rankin score (mrs) of \<4 at the screening * american heart association class b (2), allowing for aerobic capacity \<6 metabolic equivalent (met) exclusion criteria: * significant resting ecg abnormalities * hospitalization for cardiac or pulmonary disease within 3 months * using pacemaker * aphasia * significant musculotendinous or bony restrictions of the affected limb, or any serious chronic disease independently causing disability or profound atrophy of the affected limb that will comprise further indications to participation significant.

Keywords: low-volume interval training resistance training
orthostatic hypotension in hypertensive patient hospitalized in internal medicine

Conditions: Hospitalization

Summary: the two scientific societies fadoi and siia have decided to start a collaborative study protocol that, through the application of a simple and homogeneous method to diagnose orthostatic hypotension, aims to estimate prevalence, conditions associates and outcomes in a cohort of patients admitted to internal medicine departments and with known or newly diagnosed arterial hypertension.

the ip-op study, is an observational, multicenter, prospective, national study that provides for the involvement of 34 operating units of internal medicine, and the recording of data relating to 1000 hospitalized adults. the clinical data of all consecutive patients diagnosed with arterial hypertension hospitalized in internal medicine and able to take the erect station will be collected.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * presence of arterial hypertension (known or discovered at hospitalization) * signature of informed consent exclusion criteria: * patients unable to take the standing station for a few minutes

Keywords: orthostatic hypotension internal medicine
iv lidocaine on postoperative pain and qor on morbid obese patients undergoing bypass surgery

Conditions: Pain; Obesity

Summary: can intraoperative systemic lidocaine decrease postoperative opioid consumption and improve quality of recovery after laparoscopic gastric bypass surgery? the hypotheses:does the use of intraoperative systemic lidocaine decrease postoperative opioid consumption and improve quality of recovery after laparoscopic gastric bypass surgery. this study has the potential to confirm an opioid sparing strategy for morbid obese patients undergoing laparoscopic gastric bypass surgery. the high incidence of obstructive sleep apnea and the increased risk of postoperative hypoxemia make the development of opioid sparing techniques in this patient population warranted.


Eligibility criteria:
inclusion criteria: * asa i, ii,iii; * bmi \> 35 kg/m2, * age between 18-70, * fluent in english, * patients undergoing laparoscopic gastric bypass, * ekg within 3 months. exclusion criteria: * history of allergy to local anesthetics, * history of chronic opioid use, * pregnant patients, * history of ekg abnormalities. dropout: conversion to open, patient or surgeon request.

Keywords: gastric surgery pain recovery laparoscopic surgery
longitudinal therapeutically non-interventional study of msrv-env burden in normal population

Conditions: Multiple Sclerosis

Summary: this study intends to explore the levels of msrv expression by analyzing the levels of msrv transcripts in blood, as well as the levels of the msrv-env protein in serum in the normal population. this study is important for establishing a baseline to analyze results obtained in ms patients (another dedicated study is performed in parallel in ms patients). the study will be conducted over one year in a cohort of healthy subjects. the msrv rna level, msrv-env protein levels, reverse transcriptase activity, inflammatory markers assessed by cytokines levels will be analysed to define control levels in the normal population and their variation during one year. the data obtained in this study in healthy controls will be compared to those obtained in a parallel similar study, gn-e-002, conducted in different types of ms patients.


Eligibility criteria:
inclusion criteria: * signature of an informed consent; * male or female between 18 and 60 years of age. exclusion criteria: * positive serology for hepatitis b or c or hiv; * acute infection at inclusion; * severe psychiatric disorder, neurological, inflammatory, or autoimmune disease; * pregnancy or breastfeeding; * heavy smokers i.e. more than 10 cigarettes per day; * history of alcohol or drug abuse in the last 3 years; * participation in a clinical trial (within the last 3 months).

Keywords: multiple sclerosis (ms) multiple sclerosis associated retrovirus (msrv) msrv envelop protein (msrv-env) temelimab
bay14-2222 continuous infusion in surgeries

Conditions: Hemophilia

Summary: phase iii study, to evaluate the efficacy and safety of continuous infusion of rfviii-fs in the treatment of patients with hemophilia a undergoing major elective surgery by achieving the required therapeutic concentrations.


Eligibility criteria:
inclusion criteria: * severe hemophilia a (fviii:c \</=1%) * no history of fviii inhibitor formation and no current evidence of inhibitor antibody (bethesda assay \< 0.6 bu) * elective major surgery requiring at least 6 days of rfviii-fs therapy * subjects should have been previously treated with fviii concentrates for at least 150 exposure days. previous treatment could have been with any type of rfviii or with plasma-derived fviii concentrate or cryoprecipitate exclusion criteria: * abnormal renal function (serum creatinine \>1.3 mg/dl) * any treatments, which may change the clearance of fviii (dialysis, plasma exchange) * anemia (hemoglobin \<11 g/dl) * known aids (hiv seropositive patients may be enrolled) * active liver disease (transaminases \> 5 times the upper limit of normal) * history of severe reaction to fviii concentrates * interferon treatment within the last 3 months * thrombocytopenia (\< 100,000 platelets/mm3) or other known hematological/bleeding problems other than hemophilia a * intake of other investigational drugs within 1 month prior to study entry * need for pre-medication for fviii infusions (e.g. antihistamines) * diastolic blood pressure \>100 mm/hg, which could not be controlled with antihypertensive medications

Keywords: hemophilia, continuous infusion