Kornimate/medical-research-clean huggingface dataset:
longitudinal brain health in youth tackle football players

Conditions: Concussion, Brain; Athletic Injuries

Summary: the purpose of this study is to determine the neurologic and cognitive effects of playing tackle football in grade school and high school. during contact practices and games, players wear a football helmet containing an impact sensor. before and after each season, players complete neurological testing to measure several different aspects of brain function. two groups of football players will be in the study: 5th and 6th grade tackle football players from the brighton bulldogs football and cheer league (about 70 players). varsity football players from brighton high school (about 70 players per year). the study begins in july 2016 and will continue for 4 years (through the winter of 2020).

football players wear a football helmet containing the insite impact response system that measures when, how hard, and where the helmet is hit. coaches (or athletic trainer) are notified of threshold impacts via a sideline handheld device. each year pre and post-season, subjects will complete several tests of brain function during a clinic visit. these tests are listed in the "secondary outcomes" section. specific aims: 1. to quantify the cumulative head impact burden during consecutive seasons of youth tackle football and high school football. 2. to detect impairment in neurologic and cognitive function from playing youth tackle football and high school football. 3. to use cumulative head impact burden to predict the development of neurologic and neurocognitive impairment. 4. to compare the effect of head impacts on youth tackle football players verses high school football players.

Eligibility criteria:
inclusion criteria: * male football players 9-19 years of age at time of enrollment. * youth football: * 5th and 6th grade tackle football players from the brighton bulldogs football and cheer league. * high school football: * varsity brighton high school football players. exclusion criteria: * history of moderate or severe traumatic brain injury. this is defined as loss of consciousness \>30 minutes or amnesia \>24 hours. * hearing problem preventing completion of the study testing. * legal blindness, preventing completion of the study testing. * non-english speaking subjects, preventing completion of the study testing. * ward of the state.

Keywords: concussion subconcussive impacts brain function football
the impact on recurrence risk of adjuvant transarterial chemoinfusion (tai) versus adjuvant transarterial chemoembolization (tace) for patients with hepatocellular carcinoma and portal vein tumor thrombosis (pvtt) after hepatectomy : a random, controlled, stage iii clinical trial.

Conditions: Hepatocellular Carcinoma

Summary: to compare the impact on recurrence risk of adjuvant tai and adjuvant tace for patients with hcc and pvtt after hepatectomy.


Eligibility criteria:
inclusion criteria: * older than 18 years old and younger than 75 years; * ecog ps\<3; * proven hepatocellular carcinoma with pvtt according pathological examination; * not previous treated for tumor; * tumor and tumor thrombosis were removed in operation; * no recurrence occurence at 4 to 7 weeks after surgery; * the lab test could meet: neutrophil count≥1.5×109/l; hemoglobin≥80g/l; platelet count≥60×109/l; serum albumin≥28g/l; total bilirubin\<3-times upper limit of normal; alt\<5-times upper limit of normal; ast\<5-times upper limit of normal; serum creatine\<1.5-times upper limit of normal; pt≤upper limit of normal plus 6 seconds; inr≤2.3; * sign up consent; * unrolled by other clinical trials about hepatocellular carcinoma. exclusion criteria: * cannot tolerate tace or tai; * cns or bone metastasis exits; * known history of other malignancy; * be allergic to related drugs; * underwent organ transplantation before; * be treated before (interferon included); * known history of hiv infection; * known history of drug or alcohol abuse; * have gi hemorrhage or cardiac/brain vascular events within 30 days; * pregnancy;
enhancing pap adherence among spanish-speaking hispanic adults with osa

Conditions: Obstructive Sleep Apnea

Summary: this study seeks to enhance long-term positive airway pressure (pap) adherence among spanish-speaking hispanics, a group with known pap outcomes disparities. this study will assess the feasibility of a linguistically and culturally adapted tele-management intervention (automated management, am) for spanish-speaking hispanic adults with osa.

this feasibility study seeks to enhance long-term positive airway pressure (pap) adherence among spanish-speaking hispanics, a group with known pap outcomes disparities. this study will assess the feasibility, usability and 6-month effectiveness of a linguistically and culturally adapted efficacious tele-management intervention (automated management, am) for spanish-speaking hispanic adults with obstructive sleep apnea (osa) (n=50). a prospective, randomized, parallel group, unblinded, feasibility trial is proposed. am is a tele-management strategy that includes evidence-based components for improving shorter-term pap adherence consisting of education, support and troubleshooting, and brief targeted motivational enhancement delivered by tele-messaging. the automated two-way, interactive communication is algorithmic based on pap use and behavioral profiles defined at baseline. the innovative, technology-based interventions are designed to ensure access to sustained care that overcomes barriers such as distance/geography, transportation limitations or lost work/productivity time. as such, am can provide equitable access to quality long-term pap management that may mitigate known pap adherence disparities for minority adults with osa. if effective for long-term pap adherence, these strategies may alter osa care paradigms, improve outcomes and associated healthcare costs, and reduce disparities.

Eligibility criteria:
inclusion criteria: * spanish-speaking and reading * self-identified hispanic * adults ≥ 18 years-old * males and females * moderate-severe osa defined as ahi ≥15 events/hour using a hypopnea criterion of a 4% oxygen desaturation (ahi4%) * expected availability for the duration of the study (6 months from date of randomization) * ownership of smartphone with unlimited text messaging capability * referred to pap treatment and able and willing to be treated with pap exclusion criteria: * other sleep apnea or nocturnal respiratory insufficiency or failure diagnosis other than osa established by polysomnogram (psg) or home sleep apnea test (hsat) * requirement of supplemental oxygen or other non-invasive ventilation modality * women referred to pap because of new-onset osa with pregnancy as pap treatment may be time-limited (enrolled women who become pregnant during the trial and are already on pap treatment will not be excluded) * anticipated or scheduled bariatric surgery and/or referred to sleep evaluation by bariatric surgery

Keywords: positive airway pressure (pap) adherence hispanic tele-management
drug related problems among patients with femoral neck fractures in an orthopedic ward

Conditions: Femoral Neck Fractures

Summary: the purpose of the study is to: 1. identify and characterize drug related problems in patients after a femur neck fracture that are hospitalized in the orthopedic department at "meir" medical center. 2. evaluate the contribution of a clinical pharmacist in identifying,characterizing and preventing drug related problems in patients after a femur neck fracture that are hospitalized in the orthopedic department at "meir" medical center.


Eligibility criteria:
inclusion criteria: * patients over 64 * patients after a femoral neck fracture * patients hospitalized in the orthopedic ward at "meir" medical center * patients who speak hebrew, russian or english exclusion criteria: * patients under 64 * patients without a femoral neck fracture * patients who don't speak hebrew, russian or english

Keywords: drug related problems clinical pharmacist femoral neck fractures orthopedic patients
cleanser for acute wounds

Conditions: Acute Wound

Summary: the proposed study will be a prospective trial of management of acute traumatic wounds (less than 24 hours from injury and without previous intervention aside from a dressing for coverage). the study design involves a prospective single arm, 35 subject study that analyzes the effect of the subsequent application of a novel wound cleanser and wound gel on subjects' acute traumatic wounds and the respective microbial loads over a 28 day study duration.


Eligibility criteria:
inclusion criteria: * ages 18 to 89 years old. * patients receiving care in the ed/trauma bay or admitted to brooke army medical center (bamc) from the ed or trauma bay. * at least one wound area must measure equal to or greater than 2cm\^2 to include partial or full thickness tears. * wound sustained less than 48-hours from time of enrollment. * the wound must be untreated/open beyond bedside stabilization such as irrigation and debridement (i.e., no stitches, steristrips, dermabond, or washouts, etc). * capable of providing informed written consent by self or through legally authorized representative (lar). * ability to read/speak english (participant and/ or lar). exclusion criteria: * ages less than 18 or greater than 89 years old. * patients not receiving care in the ed/trauma bay or admitted to bamc through the ed or trauma bay. * wound area less than 2 cm2. * wound sustained greater than 48-hours from the time of enrollment. * wounds that have been closed/repaired at the time of screening (i.e. stitches, steristrips, dermabond, washouts in the or, etc.) or anytime during the study duration. * not capable of providing informed written consent by self or through lar. * non-english reading and speaking (participant and/or lar). * have received more than one dose of antibiotics prior to enrollment or during the study duration. * suspected or confirmed signs/symptoms of active wound infection or gangrene. * patients with osteomyelitis. * wounds with exposed tendons, ligaments, or bone. * patients undergoing active renal dialysis. * patients receiving (within 30 days of enrollment) or scheduled to receive a medication or treatment which is known to negatively affect wound healing such as systemic steroids (i.e. continuous prednisone), immunosuppressive therapy, chemotherapy, autoimmune disease therapy, cytostatic therapy, vascular surgery, angioplasty, or thrombolysis. * pregnant, breastfeeding, or women of childbearing potential who do not agree to use an effective form of contraception during their participation in the study. * participation in another investigational device, drug, or biological trial that may interfere with results within 30 days of screening. * anyone deemed by the pi to be unlikely to comply with all study procedures.

Keywords: traumatic wounds biofilm antimicrobial sepsis infection wound
using stable isotopes to assess the effectiveness of vitamin a supplementation in cameroon

Conditions: Vitamin A Deficiency

Summary: this is a study to evaluate the effects of vitamin a supplementation program on the vitamin a status of preschool children. all children aged 3-5 years who do not have severe illness and are not planning to move from the study area are eligible. children whose caregivers agree to sign the consent form will be enrolled in their community and submitted to a longitudinal evaluation of vitamin a status before and after vitamin a supplementation campaign. vitamin a status will be assessed by measuring serum retinol, retinol binding protein and vitamin a total body pool size using stable isotope dilution methodology.

five months after the last supplementation (day 0), an oral dose (2 mg retinol equivalents) of label vitamin a (\[2h8\]-retinyl acetate) in oil will be administered to 80 eligible children together with a low vitamin a high-fat snack. fasting venous blood samples (about 7 ml) will be collected into evacuated foil-wrapped blood collection tubes specifically designed for the collection of serum (containing no anticoagulant and metal free) on the mornings of days 0 before the administration of the dose and on day 14 for quantitative estimation of initial vitamin a pool size and determination of potential confounding parameters (crp, agp, iron, zinc, malaria, carotenoids and retinoids). about six months after the last supplementation (day 30), each child will received the vitamin a supplement. after 30 days and 90 days, two groups of 40 children (grp1, grp2) will respectively received a second dose of labeled vitamin a (\[2h4\]-retinyl acetate); fasting venous blood samples will be obtained before the administration of the dose and 14 days after dosing for quantitative estimation of final vitamin a pool size and determination of potential confounding parameters.

Eligibility criteria:
inclusion criteria: * children will be included if they are in the target age range (36-59 months), are not planning to move from the study area for the duration of the study and do not have severe illness at the time of enrolment exclusion criteria: * exclusion criteria will generally include the following conditions: severe anaemia, severe acute malnutrition, obesity, or clinically defined severe illness, such as dehydration, severe diarrhoea, malaria or severe respiratory illness
mechanisms of vascular damage in patients with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: a randomised controlled trial will be performed to evaluate the effects of lung volume reduction surgery (lvrs) in patients with copd on systemic inflammation, oxidative stress, endothelial function, arterial stiffness and blood pressure. we hypothesize that lvrs will lead to a reduction of systemic inflammation, oxidative stress, arterial stiffness and blood pressure and to improved endothelial function. for this purpose 30 patients with severe/very severe copd (gold iii-iv) and pulmonary emphysema who are to undergo lvrs will be randomised to one of two groups: group 1 receiving immediate lvrs and group 2 receiving lvrs after a delay of 3 months. measures of systemic inflammation, oxidative stress, endothelial function, arterial stiffness and blood pressure will be measured at baseline and 3 months after surgery and no surgery, respectively (group 2 receiving surgery only after a delay of 3 months will serve as control group) to investigate the effects of lvrs on the described outcomes.

not desired

Eligibility criteria:
inclusion criteria: * dyspnea at rest or at minimal physical activity, severe limitation of exercise capacity (6-min walk distance \< 350 m). * acceptance of an increased perioperative mortality (approximately 2 %) and/or morbidity (long lasting hospitalization due to prolonged air leaks) * copd (gold guidelines) with severe obstructive ventilatory defect (fev1 \<35% predicted) * functional aspects of lung emphysema, i.e. irreversible hyperinflation with a residual volume to total lung capacity ratio (rv/tlc) of \>0.65 and an impaired total lung diffusion capacity (dlco), usually \< 40% predicted. * pulmonary emphysema confirmed by high resolution computer tomography exclusion criteria: - current smokers * age \> 75years * "vanishing" lung or diffuse lung emphysema on ct, fev1 \ 7.3kpa) * overt active coronary artery disease, severe left ventricular function impairment * pulmonary hypertension with a mean pulmonary artery pressure \>35 mmhg at rest * acute bronchopulmonary infection, bronchiectasis on high resolution tomography * pulmonary cachexia (body mass index \<18kg/m2) * neoplastic disease with a life expectancy of less than 2 years * addiction to alcohol/drugs * relevant renal (creatinine \>150ug/ml), active gastroenterological (gi-bleeding in the previous year, abnormal liver function, active inflammatory bowel disease) or active neurological disease.
the application value of deep learning-based nomograms in benign-malignant discrimination of ti-rads category 4 thyroid nodules

Conditions: Thyroid Nodule

Summary: this retrospective study focuses on benign and malignant classification of thyroid nodules using deep learning techniques and evaluates the value of deep learning based nomograms in the classification of ti-rads category 4 thyroid nodules to improve the accuracy of benign and malignant identification of ti-rads category 4 thyroid nodules. materials and methods: patients who visited in the first affiliated hospital of shandong first medical university ＆ shandong provincial qianfoshan hospital were collected. their general clinical features, information on preoperative ultrasound diagnosis, and postoperative pathologic data were reviewed.


Eligibility criteria:
inclusion criteria: 1. ultrasound-confirmed diagnosis of thyroid nodules that are classified as ti-rads category 4. 2. availability of pathological results. exclusion criteria: 1. lack of pathological diagnosis. 2. history of thyroid surgery or other treatments. 3. poor quality of ultrasound images of thyroid nodules. 4. incomplete clinical and imaging data of the patient.

Keywords: ti-rads category 4 thyroid nodules yolov3 model nomograms
efficacy and safety of vildagliptin in combination with glimepiride in patients with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: many people with type 2 diabetes cannot maintain target blood glucose levels when taking a single oral drug. the purpose of this study is to assess the safety and effectiveness of two doses of vildagliptin, an unapproved drug, in lowering overall blood glucose levels when added to glimepiride in people with type 2 diabetes not at target blood glucose levels on a sulfonylurea alone.


Eligibility criteria:
inclusion criteria: * blood glucose criteria must be met * previously treated with a sulfonylurea for at least 3 months * body mass index (bmi) in the range 22-45 exclusion criteria: * type 1 diabetes * pregnancy or lactation * evidence of serious cardiovascular complications * evidence of serious diabetic complications * laboratory value abnormalities as defined by the protocol * known sensitivity to glimepiride * other protocol-defined exclusion criteria may apply

Keywords: type 2 diabetes vildagliptin
feasibility, acceptability, and preliminary efficacy of a novel personalized mobile intervention for suicide - open trial (2)

Conditions: Suicide; Suicide and Self-harm; Suicide, Attempted; Suicidal Ideation

Summary: the primary aim of this grant is to conduct pilot testing on a novel personalized mobile intervention for suicide - mobile application to prevent suicide (maps) - and to establish feasibility, acceptability, safety, and primary outcomes (i.e., suicidal ideation and behavior; re-hospitalization).


Eligibility criteria:
inclusion criteria: * suicidal ideation and/or suicidal behavior in the past month verified by the c-ssrs * between the ages of 18 and 26 * english proficiency * comfortable with smartphone technology * deemed by the treatment team to be stable enough to complete study procedures exclusion criteria: * current psychotic or manic symptoms severe enough to interfere with study procedures
cat-pad exposure chamber study

Conditions: Cat Allergy

Summary: cat allergy is an increasingly prevalent condition, affecting 10-15% of patients with allergic rhinoconjunctivitis and/or asthma. cat-pad is a novel, synthetic, allergen-derived peptide desensitising vaccine, currently being developed for the treatment of cat allergy. this study will look at the efficacy, safety and tolerability of two doses of cat-pad in cat allergic subjects following challenge to cat allergen in an eec.

this study is designed as a randomised, double-blind, placebo-controlled, parallel group study to evaluate the safety and tolerability of cat-pad in cat allergic subjects with allergic rhinoconjunctivitis,subjects may also have controlled asthma. the efficacy of cat-pad will be explored in subjects using an(environmental exposure chamber)eec. the study will consist of 3 study periods. in period 1, screening will be performed up to a maximum of 12 weeks before randomisation and may consist of one or two visits to the clinic, at the investigator's discretion. baseline challenge will consist of 4 visits to the eec at least 3 days before randomisation. in period 2, subjects in each cohort complying with the inclusion/exclusion criteria will be randomised to one of three groups and will receive treatment every 2 weeks (±2 days) for 14 weeks. in period 3, post treatment challenge will consist of 4 visits to the eec 18-22 weeks after the first administration in the treatment period and assessments will be performed identical to those at the baseline challenge. follow-up will be conducted 3-10 days after ptc.

Eligibility criteria:
inclusion criteria: * male or female, aged 18-65 years * minimum 1-year history of rhinoconjunctivitis on exposure to cats. (subjects may also have controlled asthma) * positive skin prick test to cat allergen with a wheal diameter at least 3mm larger than that produced by the negative control * minimum qualifying rhinoconjunctivitis symptom scores exclusion criteria: * "partly controlled" and "uncontrolled" asthma * history of anaphylaxis to cat allergen * fev1 of less than 70% of predicted * subjects who cannot tolerate baseline challenge in the eec * treatment with beta-blockers,alpha-adrenoceptor blockers, tranquillizers or psychoactive drugs * a history of any significant disease or disorder (e.g. cardiovascular, pulmonary, gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, neoplastic/malignant, psychiatric, major physical impairment)

Keywords: cat allergy rhinoconjunctivitis exposure chamber immunotherapy cat-pad
pulsed radiofrequency of shoulder individual nerves versus brachial plexus in management of chronic post mastectomy shoulder pain

Conditions: Pulsed Radiofrequency; Shoulder Individual Nerves Brachial Plexus; Chronic; Post Mastectomy; Shoulder Pain

Summary: this study aims to assess the role of pulsed radiofrequency of the brachial plexus or pulsed radiofrequency of shoulder individual nerves in the management of post-mastectomy shoulder pain.

breast cancer is the second most common cancer world-wide following lung cancer. it afflicts about 1.7 million patients annually, of which 60% mandate surgery of the breast and/or the axilla, and nearly 20-50% of them may develop post-mastectomy pain syndrome. regarding pulsed rf of the brachial plexus, it is not tried up till now for shoulder pain. since c 5,6,7 are derived from upper and middle trunks of brachial plexus, then innervation of shoulder joint can be blocked by interscalene brachial plexus block or pulsed radiofrequency . review of literature demonstrated efficacy of prf of brachial plexus in case studies for other conditions e.g. pain associated with a tumor involving the brachial plexus , refractory stump pain , chemotherapy-induced peripheral neuropathy of the upper limb and radiation-induced brachial plexopathy .

Eligibility criteria:
inclusion criteria: * age (18-65) years. * american society of anesthesiologists (asa) physical status (ii- iii). * patients with post mastectomy shoulder pain. * body mass index (bmi): (20-40) kg/m2. * patients on maximum daily dose tramadol ( 450mg ) and still in pain exclusion criteria: * patient refusal. * known sensitivity or contraindication to drugs used in the study. * pregnancy. * recent myocardial infarction. * hemodynamically unstable. * local and systemic sepsis. * psychiatric illness.