Kornimate/medical-research-clean huggingface dataset:
investigating the association between central sensitization and breathing pattern disorders

Conditions: Central Sensitisation

Summary: breathing pattern disorders can cause mechanical, physiological, and psychological issues in the body, contributing to the initiation and chronicity of pain. therefore, considering breathing patterns is significant in managing chronic pain, yet direct research on central sensitization and breathing pattern disorders remains scant. this study aims to analyze the correlation between central sensitization and breathing pattern disorders in adults by assessing both respiration and pain.

breathing pattern disorders impact consciousness and the body according to respiratory patterns, leading to physiological, mechanical, and psychological disturbances. unlike normal breathing patterns facilitated by appropriate diaphragmatic activity, incorrect patterns often exhibit reduced diaphragmatic engagement. chest breathing patterns are prevalent among chronic pain patients, characterized by limited upper chest segment movement due to prolonged improper respiration without specific pathological symptoms. fluoroscopy studies reveal flattened and tense diaphragms with diminished relative mobility, implicating accessory and inspiratory muscles more heavily in ventilation. biologically unsustainable functional breathing patterns correlate with chronic musculoskeletal issues and pain. prior research establishes associations between inappropriate breathing patterns and chronic lower back pain and scapular dysfunctions. consequently, managing chronic pain clinically necessitates functional recovery and pain relief, crucial for sustaining daily life. therefore, researching central adaptations and respiration in chronic pain management is imperative, yet remains insufficiently explored.

Eligibility criteria:
inclusion criteria: * adults aged 18 and above. * individuals scoring 40 or above on the central sensitization inventory for koreans (csi-k). * individuals who consent to the use and publication of their personal information and wish to participate in assessment measurements. exclusion criteria: * individuals with pulmonary, cardiac, or respiratory diseases. * individuals with severe hypertension, defined as systolic blood pressure ≥ 160 mmhg or diastolic blood pressure ≥ 100 mmhg. * individuals with cognitive impairments. * individuals who express a desire to withdraw from the study during its duration.

Keywords: central sensitization breathing pattern disorders chronic pain
perennial allergic rhinitis study in pediatric subjects

Conditions: Rhinitis, Allergic, Perennial

Summary: the purpose of this study is to determine if the investigational drug is effective and safe in children with perennial allergic rhinitis.

a randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the safety and efficacy of once-daily, intranasal administration of gw685698x aqueous nasal spray 50mcg and 100mcg for 12 weeks in pediatric subjects ages 2 to \<12 years with perennial allergic rhinitis (par)

Eligibility criteria:
inclusion criteria: * diagnosis of perennial allergic rhinitis. exclusion criteria: * have significant concomitant medical conditions. * use of corticosteroids or other allergy medications during the study. * have abnormal ecg. * have laboratory abnormality. * have abnormal eye exam.

Keywords: perennial allergic rhinitis pediatric
hepatic manifestations and effect of long covid-19 on patients with chronic liver disease

Conditions: COVID-19

Summary: to measure the frequency of persistent liver dysfunction (raised liver enzymes, serum albumin, prothrombin time, etc) in recovered covid -19 patients. to compare the hepatic manifestations in post covid -19 patients with and without liver disease

the digestive tract, particularly the liver, has recently been reported to be affected by sars-cov-2. although abnormal liver enzymes were regularly described as an extra-pulmonary clinical feature, and almost one half of patients experienced grades of hepatic injury. liver damage in patients with sars infections was primarily manifested in the mild and moderate elevation of alanine and/or aspartate aminotransferases (alt and ast) with some degree of hypoalbuminemia and hyperbilirubinemia during the early stage of the illness.

Eligibility criteria:
inclusion criteria: * patients previously diagnosed by covid 19 eg : pcr and / or hrct chest, lab of more than 1 month duration. exclusion criteria: * patients less than 18 y. * patients with acute covid 19.
naloxone auto-injection in healthy volunteers

Conditions: Overdose Antidote

Summary: this study continues the work to develop a mobile breathing monitoring system to detect slowed breathing and overdose events caused by opioid use. this is a single-site feasibility study designed to test the mobile application with a commercially available drug delivery device called the smartdose by west pharmaceuticals, inc. the smartdose is a wearable self-injection device that can deliver a drug under the skin with a push of a button. naloxone is a drug used to reverse the effects of opioid drugs in the body. this study will evaluate if the mobile application can wireless trigger the delivery of a small dose of naloxone to a healthy adult volunteer.


Eligibility criteria:
inclusion criteria: * healthy male/female volunteers * \>18 years * no allergy to naloxone or ingredients in its formulation * ability to read and understand english * written informed consent obtained from subject * ability to comply with study requirements exclusion criteria: * history of alcohol or substance abuse * history of unusual pain sensitivity, lack of sensitivity * history of chronic myofascial, inflammatory, neuropathic pain * chronic use of medication known to interfere with naloxone * pregnant women and nursing mothers * presence of a condition or abnormality that in the opinion of the principal investigator would compromise subject safety or the quality of the data (e.g., persons with liver disease, renal insufficiency/failure) * alcohol on the breath
premcry study : study of ontogeny of crying in preterm infants.

Conditions: Preterm Birth

Summary: crying is a survival mechanism for babies and their almost exclusive means of expression until the age of 4 months. babies 'cry is mostly related to pain, a feeling of hunger, discomfort or separation following the departure of a parent around. crying is a complex but essential means of communication and information between a baby and his parents that raises the question of their meaning. very few longitudinal studies have been produced on preterm's crying. as the term approaches, the characteristics of preterm babies' crying are similar to those of term infants. but these studies date back more than 30 years and are obsolete in terms of the quality and performance of sound recording equipment and signal processing. no study has looked at the genesis of the cry itself and the varieties of the cry of the preterm baby, depending on whether it was in a situation of hunger, pain, discomfort (bath).

this longitudinal study recordings of crying babies from 26 amenorrhea week to 33 amenorrhea week, 24 hours per week, each week until the return home. in the same time, parents will be asked to know the situation of the baby (hunger, pain, bath).

Eligibility criteria:
inclusion criteria: * infant born between 26 and 33 amenorrhea week * live infant at birth * parent affiliated or entitled to a social security scheme * parent who received informed written information about the study exclusion criteria: - intubated infant

Keywords: newborn ontogeny of crying preterm infants
tele-educative program to improve adherence to the use of hearing aids in patients with hearing loss

Conditions: Hearing Loss

Summary: hearing loss is the third most common chronic condition in over 65 years people, it is estimated that 77.8% of older adults suffer from it. however, there are reports of adherence to the use of hearing aids of only to 40%. the objective of this project is to measure the effectiveness of a tele-educative intervention to improve adherence to the use of hearing aids. a randomized controlled trial was performed. the active branch consists of the implementation of an educational program called active communication education, consisting of 4 sessions with a trained rehabilitator. participants will be also monitored by telephone headset use by personnel trained for three months. the control arm will consist of the usual care received by these patients. all participants will be assessed at home at 3, 6, 9, and 12 months after randomization.

introduction: hearing loss is the third most common chronic condition in over 65 years people, it is estimated that 77.8% of older adults suffer from it. delivery of hearing aids to older adults with bilateral hearing loss is included in the garantías explícitas en salud (ges) guidelines of chile. however, there are reports of adherence to the use of hearing aids of only to 40%. the ges guideline establishes the conducting of programs in audiological rehabilitation counseling, but there is no evidence that this is being developed in chile. objective: the objective of this project is to measure the effectiveness of a tele-educative intervention to improve adherence to the use of hearing aids. material and methods: a randomized controlled trial was performed. demographic and audiometric variables were recorded. the active branch consists of the implementation of an educational program called active communication education, consisting of 4 sessions with a trained rehabilitator. participants will be also monitored by telephone headset use by personnel trained for three months. the control arm will consist of the usual care received by these patients. all participants will be assessed at home at 3, 6, 9, and 12 months after randomization. the primary outcome will assess adherence to the use of hearing aids. secondarily related quality of life was assessed with hearing loss. analysis plan: data will be analyzed mediantes bivariate tests, student t for normally distributed continuous variables, and fisher exact test for categorical variables. a model of multilevel mixed effects will be drawn considering the repeated measurements of outcomes assessed. for all analysis is considered an alpha=5%.

Eligibility criteria:
inclusion criteria: * hearing loss worst than 40 db in the better ear * 65 years old or more exclusion criteria: * dementia * prior surgery for hearing loss

Keywords: aged hearing aids rehabilitation
prasugrel vs ticagrelor in st-elevation myocardial infarction patients with diabetes mellitus

Conditions: ST-Elevation Myocardial Infarction

Summary: dual antiplatelet therapy is essential in patients following st-elevation myocardial infarction (stemi) with percutaneous coronary intervention (pci) and drug eluting stent implantation. current guidelines recommend prasugrel and ticagrelor in patients with stemi undergoing primary ppci. we sought to investigate the superiority antiplatelet effect in terms of pr level of loading dose (ld) of prasugrel (60 mg) versus ld of ticagrelor (180 mg) in diabetic patients with stemi undergoing primary pci at 1 and 2 hours post drug administration. secondary end-points will be: pr level measured at 6 and 12 hours post study drugs administrationin hospital. all consecutive diabetic patients with stemi undergoing ppci with stent implantation will be considered for pr assessment at 1-2-6-12 h after the drug ld administration. all patients must will be naïve for platelet p2y12 receptor inhibition therapy. a subanalysis will be performed between two study groups according to insulin treatment.


Eligibility criteria:
inclusion criteria: * diabetic patients * acute coronary syndrome * patients underwent to primary pci * naïve for platelet p2y12 receptor inhibition therapy exclusion criteria: * history of bleeding diathesis * chronic oral anticoagulation treatment * contraindications to antiplatelet therapy * pci or coronary artery bypass grafting (cabg) \< 3 months * hemodynamic instability * platelet count \< 100,000/μl * hematocrit \< 30% * creatinine clearance \< 25 ml/min * patients with a history of stroke * contraindication for prasugrel administration * patients weighing \< 60 kg * patients treated with morphine * \> 75 years of age.

Keywords: diabetes mellitus antiplatelet effect prasugrel ticagrelor stemi insulin
lafiya hiv-status neutral study - protocol

Conditions: HIV Prevention and Care

Summary: the primary objective of this study is to adapt and evaluate the feasibility of "lafiya," which means "wellness" in hausa, a multilevel intersectional stigma \& discrimination (isd) and hiv testing intervention, to a status-neutral intervention to increase hiv testing, prep, and art uptake (hpart) among young gay, bisexual, and other men who have sex with men in ghanaian slums. specific objectives include, assessing intersectional stigma and options for hpart implementation, adapting lafiya to a status-neutral intervention to address intersectional stigma and increase hpart uptake among ygbmsm, test acceptance, feasibility, appropriateness, and preliminary efficacy of lafiya to address intersectional stigma and increase hivst uptake.


Eligibility criteria:
inclusion criteria: * ygbmsm fgd and idi: to be eligible for fgd, the person must be between 18 to 25 years old, currently identify as a cis-gender man, have had sex with another man within 8 months before engaging with the recruitment team, and must reside within a slum community in the accra metropolitan areas. to be eligible for idis, participants must self-disclose living with hiv. * gbmsm civil society organizations fgd: the person must have experience providing gbmsm with hiv prevention and care services for at least one year. must reside in the accra metropolitan area. * hcf staff fgds: hcf staff are eligible to participate in the fgds if employed at a study-participating facility. * anti-isd trained nurses idis hcf staff are eligible to participate if they are trained in our previous interventions and have previously delivered them in a ghanaian hcf. exclusion criteria: * ygbmsm fgd and idi: persons outside the age range of 18 to 25 years old, persons who do not identify as cis-gender men, persons who have not had sex with another man within 8 months before engaging with the recruitment team. * gbmsm civil society organizations fgd: persons who do not have experience providing gbmsm with hiv prevention and care services for at least one year. persons who do not reside within a slum community in the accra metropolitan area (residence outside this area would be excluded). * hcf staff fgds: hcf staff are not eligible to participate in the fgds if they are not employed at a study-participating facility. * anti-isd trained nurses idis: hcf staff are not eligible to participate if they are not trained in our previous interventions and have not previously delivered them in a ghanaian hcf.

Keywords: hiv testing prep art msm ghana hiv status-neutral slums young men
support for cardiovascular health in african american primary care patients

Conditions: Cardiovascular Diseases; Blood Pressure

Summary: project overview: poor hypertension control has dire consequences for the african-american population who suffer greater death and disability from heart disease, stroke, and renal failure than whites. to reduce these health disparities it is critical to promote of a healthy lifestyle in regard to diet, exercise, adherence to medications, as well as other behaviors. however, physicians usually fail to address lifestyle behaviors in the context of the harried patient visit. therefore, the investigators hypothesized that the investigators could reduce cardiovascular risk by providing additional support to persons with poorly controlled hypertension through phone calls from trained peer patients and visits to an office support staff member. study design: a single-blind, randomized, controlled trial in 280 african-american primary care patients aged 40-75 with poorly controlled hypertension (htn). the intervention group receives a practice-based team intervention that combines peer coach with office staff (i.e., medical assistant or licensed practice nurse) visits to address lifestyle challenges. both intervention and control groups receive informational materials and healthy soul food recipes from the american heart association. the 6 month intervention alternates monthly phone calls from peer coaches about lifestyle behavioral changes with office-based visits with the support staff member during which patients review and discuss low literacy slide shows about healthy behaviors as well as examine their personal cardiovascular risk profile.


Eligibility criteria:
inclusion criteria: * african american * uncontrolled hypertension * at least 3 practice visits in the past 2 years * one lipid panel since 2005 exclusion criteria: * no recent lipid panel * kept less than 60% of primary care visits in the prior 2 years
follow-up of gani_med cardio cohorts

Conditions: Chronic Heart Failure; Metabolic Syndrome

Summary: follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in cvd), recruited at baseline by the gani_med-project (greifswald approach to individualized medicine). standardized protocols will be used for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. comparisons with the general background population will be performed.

5-year follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in cvd), recruited at baseline by the gani_med-project (greifswald approach to individualized medicine). subjects will be comprehensively phenotypes using standardized protocols for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. a multi-omics based biomarker assessment including genome-wide genotyping, transcriptome, metabolome, and proteome analyses complements the multi-level approach of gani_med. comparisons with the general background population as characterized by the study of health in pomerania (ship) will be performed.

Eligibility criteria:
inclusion criteria: * participation in baseline examination of gani_med cohorts (heart failure, metabolic risk) exclusion criteria: * none

Keywords: heart failure heart disease cardiovascular disease metabolic risk comorbidities
whirlpool for osteoarhritis

Conditions: Neuropathic Pain; Osteo Arthritis Knee; Sleep Disorder

Summary: both neuropathic and nociceptive mechanisms may contribute to the oa pain experience. aims: the aim of this study was to determine the efficacy of warm whirlpool on pain, disability, quality of life (qol) and sleep for patients with neuropathic pain.

whirlpool treatment method is used for medical and surgical conditions. in literature there are studies which recommend whirlpool therapy as a treatment for reducing pain in patients with osteoarthritis. the aim of this study was to determine the efficacy of warm whirlpool on pain, disability, quality of life (qol) and sleep for patients with neuropathic pain.

Eligibility criteria:
inclusion criteria: * suffering from knee pain at least 3 months * radiological manifestations considering were consistent with grade 3 and 4 knee oa due to kellgren and lawrence criteria had dn4 scores ≥4. exclusion criteria: * lower extremity surgery history, knee infection inflammatory disease like rheumatoid arthritis back or pelvic pain related with knee pain another cause of polyneuropathy (diabetes mellitus, vitamin b 12 deficiency, toxic or neurological disease like stroke, spinal cord injury) lumbar disc herniation malignancy or active systemic disease.

Keywords: neuropathic pain whirlpool osteoarthritis sleep
effect of ischemic postconditioning on targeting of annexin a5 after forearm exercise

Conditions: Cardiovascular Disease; Ischemia-reperfusion Injury; Postconditioning

Summary: to adjust our forearm model for ischemia reperfusion injury, in order to used it for assessment of ischemia reperfusion damage in elderly and patients. to test the effect of ischemic postconditioning on ischemia reperfusion injury in healthy volunteers, using annexin binding after repetitive handgripping.

recently, ischemic postconditioning has been identified as a protective intervention against ischemia-reperfusion injury. in animal studies, the signalling pathway of this (impressive) protective phenomenon is very similar to ischemic preconditioning. it opens a new avenue of post-reperfusion interventions with drugs that have been shown to mimic ischemic preconditioning. before we can study this phenomenon in our forearm ischemia-reperfusion model, we need additional validating experiments. the purpose of this study proposal is to provide these data.

Eligibility criteria:
inclusion criteria: * age 18-50 years * no physical limitation to perform ischemic exercise * informed consent exclusion criteria: * diabetes (fasting glucose \> 7,0mmol/l, or random glucose \>11,0mmol/l) * hyperlipidemia (random total cholesterol \> 6.5 mmol/l) * hypertension (supine sbp/dbp \> 140/90 mmhg at screening) * any cardiovascular disease * drug abuse * concomitant chronic use of medication * administration of radioactivity in research setting during the last 5 years * participation to any drug-investigation during the previous month as checked with vip check according to crcn standard procedures.

Keywords: cardiovascular disease ischemia-reperfusion injury postconditioning annexin targeting
hemofiltration in burns: rescue (randomized controlled evaluation of hemofiltration in adult burn patients with septic shock and acute renal failure)

Conditions: Burns; Hemofiltration; Kidney Failure, Acute; Shock, Septic

Summary: the purpose of this study is determine if high-volume hemofiltration in addition to 'contemporary' care will result in an improvement of select clinical outcomes when compared to 'contemporary' care alone in the treatment of critically ill patients with arf secondary to septic shock.

acute renal failure (arf) is a common and devastating complication in critically ill burn patients with mortality reported to be between 80 and 100%.(3-7) despite recent advances in burn care, the unacceptably high mortality rate in this subgroup has not changed over time. the pathogenesis of arf in burns, similar to other critically ill populations, is often multi-factorial with one major component being sepsis induced ischemic tubular necrosis. thus, arf secondary to septic shock is a common and devastating condition in the burn icu.

Eligibility criteria:
inclusion criteria: * all adult patients admitted to the burn intensive care unit (icu) with burns of any size * acute renal failure as previously defined by the veterans affairs/ national institutes of health (va/nih) acute renal failure trial network study investigators(2) * patient is \> 48 hours post-burn and in septic shock * patients 18 or older * patient/legally authorized representative willing to provide consent exclusion criteria: * age \<18 * non-thermal injury (exfoliating skin disorders or necrotizing fasciitis) * pre-admission diagnosis of end stage renal failure * patients already on renal replacement therapy for more than 24 hours * patient not expected to survive more than 24 hours after randomization. * pregnancy * prisoners

Keywords: burns hemofiltration vasopressins kidney failure acute shock, septic