Kornimate/medical-research-clean huggingface dataset:
home-based exercise via a telecommunications system

Conditions: Functional Limitation

Summary: this study is investigating the effects of a home-based resistance exercise program, administered via an interactive telecommunications system, in functionally limited older veterans.

inactivity and a sedentary lifestyle have been shown to accelerate and exaggerate the age-related decline in muscle strength. in this context, a rapid decline in strength among older adults has been linked to physical frailty, falls, functional decline, impaired mobility, and nursing home placement. substantial evidence now suggests that habitual physical activity is associated with the maintenance of muscle strength and physical function well into the 8th and 9th decades of life. we propose to investigate the effects of a home-based resistance exercise program, administered via an interactive telecommunications system without the participation of health professionals, in functionally limited older veterans. subjects will be randomized to either the automated exercise group or an attention placebo control group. the exercise group will undergo resistance training at home three times a week for 6 months, guided by the telecommunications system, followed by a 6-month maintenance phase of less frequent interaction with the system. outcome measurements will include muscle strength and physical performance related to daily activities at 3, 6, and 12 months to determine the efficacy of the intervention and the time course and durability of the effect. the control group will also interact with the telecommunications system once a week for the whole year, but no exercise will be prescribed. if this home-based, automated, interactive exercise program is effective, it will provide a low-cost easily disseminated approach to improving the strength and functional status of older veterans

Eligibility criteria:
inclusion criteria: * age 65 years * ability to use a telephone without assistance exclusion criteria: * angina pectoris * myocardial infarction * ventricular dysrhythmia currently receiving therapy * systolic blood pressure 165 mm hg or diastolic blood pressure 100 mm hg

Keywords: activities of daily living aging exercise weight lifting
a study to learn if 27t51, a mucin-16 (muc16) protein targeting immune cell therapy, administered alone or in combination is safe and how well it works for adult participants with recurrent or treatment resistant ovarian cancers

Conditions: Epithelial Ovarian Cancer; Primary Peritoneal Carcinoma; Fallopian Tube Cancer

Summary: this study is researching an experimental car t cell therapy called 27t51, referred to as study drug. the study drug is a muc16 targeting immune cell therapy focused on adult female participants with recurrent or difficult to treat epithelial ovarian, primary peritoneal or fallopian tube cancer. this study has two (2) major parts: phase 1a dose escalation and phase 1b dose expansion. the aim of the dose escalation part will be to test the safety of 27t51 in a small number of participants to find the highest dose given to humans without unacceptable side effects. the aim of the dose expansion part will be to test 27t51 at the established dose level(s) from the dose escalation part and may include other medications given in combination with 27t51. information collected from this study will help researchers understand more fully whether this immune cell therapy, also known as car t cell therapy, can be safely used to treat solid tumors such as ovarian cancer.

former sponsor 2seventy bio

Eligibility criteria:
key inclusion criteria: 1. eastern cooperative oncology group (ecog) performance status ≤ 1 2. histological diagnosis of epithelial ovarian, primary peritoneal, or fallopian tube cancer according to world of health organization (who) 2020 classification 3. recurrent or refractory epithelial ovarian, primary peritoneal, or fallopian tube cancer, as described in the protocol 4. serum cancer antigen (ca) 125 ≥ 2 × upper limit of normal (uln) as assessed at the local lab by a 510(k) cleared test at screening 5. participants must have at least 1 measurable tumor lesion as defined by the response evaluation criteria in solid tumors (recist) 1.1. 6. expected survival ≥ 3 months key exclusion criteria: 1. inadequate cardiovascular, renal and hepatic function, as described in the protocol 2. absolute lymphocyte count (alc) \< 100 cells/μl at time of leukapheresis 3. history of grade ≥ 2 hemorrhage within 30 days, or inadequate coagulation parameters, as described in the protocol 4. known history or presence of clinically relevant central nervous system (cns) pathology, as described in the protocol 5. ongoing or recent (within 2 years) evidence of significant autoimmune disease that required treatment with systemic immunosuppressive treatments, which may suggest risk for immune related adverse events (aes) 6. treatment with any cellular or gene therapy note: other protocol-defined inclusion/exclusion criteria apply

Keywords: ovarian cancer car t peritoneal fallopian tube muc16 immunotherapy
red blood cell distribution width as a marker of contrast induced nephropathy in patients with coronary intervention

Conditions: Contrast-induced Nephropathy

Summary: contrast induced nephropathy is an acute renal insufficiency defined as a 25% or 0.5 mg/dl increase over the baseline of the serum creatinine level 24 h to 72 h after intravascular administration of a contrast agent.

contrast induced nephropathy has been introduced an important complication after coronary angiography and percutaneous coronary intervention . the development of contrast induced nephropathy after percutaneous coronary intervention is associated with poor clinical outcomes including prolonged hospitalization, increased costs, increased rates of end-stage renal failure, myocardial infarction, repeat revascularization, and short- and long-term mortality. contrast induced nephropathy follows decreased renal perfusion and administration of nephrotoxic medications as the third most common cause of renal insufficiency during hospitalization. patients with acute coronary syndrome have a 3-fold higher risk of developing contrast induced nephropathy .therefore ,predicting contrast nephropathy and initiating therapeutic preventive strategies are very important. red blood cell distribution width is a quantitive marker of the variability on size of erythrocyte. it is a routine assay of complete blood count that doesn't require an additional cost, that is calculated by dividing the standard deviation of the mean cell size by the mean corpuscular volume of the red cells and multiplying by 100 to convert to a percentage. normal range of red blood cell distribution width 11-16%. increased red blood cell distribution width means increased variability in red blood cell size owing to ineffective erythrocyte production, which is associated with indices of inflammation and pro-inflammatory cytokines such as interleukin-6 . on the other hand, suggested mechanisms underlying contrast induced nephropathy include cytotoxic effects, factors that affect renal hemodynamic, and regional hypoxia.

Eligibility criteria:
inclusion criteria: consecutive patients who underwent percutaneous coronary intervention either elective or emergency. exclusion criteria: 1. end stage renal disease with glomerular filtration rate less than 30 ml/1.73. 2. patient known allergy to contrast agents. 3. left ventricular ejection fraction below 30%. 4. presence of infection 5. a recent history of contrast administration in the previous month. 6. patient known to have thyroid disease. 7. history of malignancy. 8. patient known to have autoimmune disease. 9. decompensated liver cirrhosis 10. cardiogenic shock. 11. anemia

Keywords: sheerly
the effect of eye movement desensitization and reprocessing intervention in hypertension patient.

Conditions: Eye Movement Desensitization and Reprocessing Intervention; Blood Pressure; Heart Rate Variability; Anxiety

Summary: eye movement desensitization and reprocessing intervention may improve anxiety, depression, systolic blood pressure and heart rate variability in patients with hypertension.


Eligibility criteria:
inclusion criteria: 1. age of 20-80 years, 2. diagnosed with primary hypertension as in sbp ≥130 mmhg or dbp ≥80 mmhg, 3. and able to read and understand chinese or taiwanese and willing to participate in this study, exclusion criteria: 1. . secondary hypertension 2. . hypertension crisis.
augmented reality for stroke rehabilitation

Conditions: Stroke/Brain Attack

Summary: the study aims to determine the effectiveness of augmented reality on motor function, balance, and functional ambulation in stroke patients.

the study aims to determine the effectiveness of augmented reality on motor function, balance, and functional ambulation in stroke patients. the emerging technology of augmented reality (ar), has been validated as a promising way to assist the rehabilitation training in stroke patients. the purpose of this study is to investigate the feasibility of the ar rehabilitation system in a real-world setting. the following questions will be addressed by the present study: (a) how the augmented reality effects motor function, balance, and functional ambulation in stroke patients? (b) how much and what types of manpower can be saved while maintaining the efficacy of training with the assistance of the ar rehabilitation? (c) how can the contact rate be reduced with the ar training? (d) how do therapists/patients experience the ar training?

Eligibility criteria:
inclusion criteria: participants falling in this category would be recruited into the study. 1. age between 18 to 90 years who are diagnosed with ischemic brain injury, intracerebral hemorrhage shown by magnetic resonance imaging, or computed tomography after the onset of stroke; 2. with motor impairment in the upper limb, lower limb, and/or balance; 3. have no or mild spasticity on the lower limb or upper limb assessed by modified ashworth scale (mas ≤ 2); and 4. have sufficient cognition to follow the instructions provided by the therapists and the computer. exclusion criteria: participants fall in this category would be excluded of the study. 1. any additional medical or psychological condition that would affect their ability to comply with the study protocol, e.g., a significant orthopedic or chronic pain condition, major post-stroke depression, epilepsy, artificial cardiac pacemaker/joint; 2. have severe shoulder/arm or hip/knee contracture/ pain and; 3. pregnant women.

Keywords: stroke rehabilitation augmented reality balance motor function
effects of pilates exercises applied with face-to-face and telerehabilitation on menstrual pain

Conditions: Menstrual Pain

Summary: pain is one of the most common symptoms of menstrual syndrome that significantly affects quality of life. the aim of our study is to compare the effect of pilates on menstrual pain and the effectiveness of the applications within themselves.

20 women experiencing severe pain during menstruation were randomized into two groups. the same exercise program is applied to 10 participants face-to-face, and to 10 participants via telerehabilitation. exercises are applied for 6 weeks, 2 days a week. visual analog scale (vas) is used for pain assessment, sf-36 short form is used to assess quality of life, and menstrual attitude scale is used to assess symptoms in the premenstrual/menstrual period. evaluations are performed twice in total, before and after treatment. statistical analysis will be performed with spss 24.0 program. if the data is parametric, paired sample t-test will be used for within-group evaluation; independent sample t-test will be used for between-group evaluation. if the data is non-parametric, wilson test will be used for within-group evaluation and mann whitney u test will be used for between-group evaluation.

Eligibility criteria:
inclusion criteria: * people between the ages of 18-30 who have a continuing menstrual cycle. * women with menstrual pain vas\>5. * people with regular menstrual cycles. exclusion criteria: * being in menopause. * using birth control pills. * taking hormone therapy. * having exercise intolerance.
family focused nursing for elderly medical patients

Conditions: Depression

Summary: the purpose of this study is to determine whether family focused nursing are effective in the treatment of elderly medical patients with respect to prevalence of depression

psychosocial issues such as lack of social support and symptoms of depression, are risk factors associated to readmission for elderly medical patients. families with elderly members in general want to be involved in the caring and want to maintain a close relation to their elderly family member. however, disease in a single family can have a negative effect on all members and may result in dysfunction of the family. international guidelines recommend that the patient's relatives are involved in patient education as well as the treatment. family interventions might contribute to decline depression and readmissions, besides enhanced quality of life and family function among elderly medical patients and their next of kin.

Eligibility criteria:
inclusion criteria: * acute hospitalized * an expected hospitalization of minimum two days * speak and understand danish * signed informed consent exclusion criteria: * dementia (evaluated by the mini mental state examination \[mmse\] \< 24) * terminally ill patients whose survival rate is assessed to be less than a month

Keywords: depression family functioning family focused nursing quality of life
study on the association between sxci and rm and the possible genetic mechanism

Conditions: Infertility Female; Recurrent Miscarriage

Summary: to determine whether there is higher incidence of skewed x chromosome inactivation(sxci) in the recurrent miscarriage(rm) population compared with normal population, and verify the existing hypothesis of the possible genetic mechanisms underlying the association between sxci and rm.

recurrent spontaneous abortion (rsa), defined as 2 or more consecutive pregnancy losses before 20-22 weeks of gestation, is a multifactorial disorder that affects about 5% of all couples.in up to 50% of women who have experienced rsa, the cause still remains unexplained, with genetic problem proposed as a main cause. x chromosome inactivation (xci) is a physiological phenomenon in female mammals for 'dosage compensation' of x-linked genes with males. a normal female is mosaic, with about one-half of her somatic cells expressing the paternal derived x and the remainder of her cells using maternal x. in some situations, however, the inactivation is not random, resulting in a female having most or even all her somatic cells inactivating the same x chromosome from either paternal or maternal resource, which is known as skewed x-chromosome inactivation (sxci).evidence of an association between skewed x chromosome inactivation (sxci) and idiopathic recurrent spontaneous abortion (rsa) is conflicting. this is a single-center observational case-control trial to determine whether there is higher incidence of skewed x chromosome inactivation(sxci) in the recurrent miscarriage(rm) population compared with normal population, and verify the existing hypothesis of the possible genetic mechanisms underlying the association between sxci and rm.

Eligibility criteria:
inclusion criteria: * 1) regular menstrual cycles and normal level of e2, p, fsh, lh, t, rpl in the early follicular phase; 2) no history of gynecologic or other pelvic operations; 3) no history of hormone medicine application in the last 3 months; 4) no history of poison contact; 5) normal uterine and adnexal ultrasonography; 6) torch(-), chlamydia(-), mycoplasma(-), normal leucorrhoea routine, anti-phospholipid antibody (-), antinuclear antibody(-); 7) for the couple, no blood type incompatibility or abo antibody igg≤1：64 and normal blood chromosome analysis; 8) condoms are used for contraception. exclusion criteria: * 1) bmi\ 24.9; 2) hydrosalpinx without operation; endometriosis; polycystic ovary syndrome; adenomyosis; uterine leiomyomata(submucous myoma or non-submucous myoma which size was exceed 4cm and/or with the compressed endometrium);uterine cavity lesions(such as uterine malformation, intrauterine adhesions, the septate uterus, endometritis etc); 3) the former abortion is because of luteal phase defect without treatment; 4) fsh≥12iu/l or amh\<1.2ng/ml 5) thyroid dysfunction or increased ca125 level; 6) acute inflammation of genitourinary system or std carriers; 7) unable to comply with the study procedures.
immune disorder hsct protocol

Conditions: Immune Deficiency Disorders; Severe Combined Immunodeficiency; Chronic Granulomatous Disease; X-linked Agammaglobulinemia; Wiskott-Aldrich Syndrome; Hyper-IgM; DiGeorge Syndrome; Chediak-Higashi Syndrome; Common Variable Immune Deficiency; Immune Dysregulatory Disorders; Hemophagocytic Lymphohistiocytosis; IPEX; Autoimmune Lymphoproliferative Syndrome; X-linked Lymphoproliferative Syndrome

Summary: this study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. a regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.


Eligibility criteria:
inclusion criteria: * \</= 28 years of age * performance status \>/= 40 * dlco \>/= 40% * lvef \>/=40% or lvsf \>/=26% * serum creatinine \< 2x uln * liver enzymes \</= 5x uln * negative pregnancy test * suitably matched donor (6/6 matched sib ucb, 8/8 matched sib bm or pbsc, 5-6/6 matched unrelated ucb, 7-8/8 matched unrelated bm, double cord) exclusion criteria: * known diagnosis of hiv i/ii * pregnant or breastfeeding * uncontrolled invasive fungal or bacterial infections within 1 month prior to starting alemtuzumab * uncontrolled viral infection within 1 week prior to starting alemtuzumab

Keywords: immune deficiency immune disorders immune dysregulatory reduced intensity alemtuzumab campath
psychoactive drug uses among medical and pharmacy students

Conditions: Psychoactive Substance Use Disorder

Summary: drug addiction to psychoactive substances, widely consumed in france, represents a major public health issue. the three main motivations identified for the consumption of psychostimulants would be self-medication, the party aspect and the improvement of school performance. students of medicine and pharmacy are a population exposed to academic and professional stress, vulnerable to health problems and psycho-social disorders (anxiety, depression), with direct access to many drugs at their workplace. almost a third of these students declared to consume these products to improve their cognitive performance, while a recent study showed that they take them instead to manage their stress and sleep. however, no study has characterized all the different uses of psychoactive drugs (pad) in this population, nor the motivations for consumption, while an analysis of motives would help to develop better screening and prevention strategies. the main objective of the research is to characterize the motivations for pad consumption among students of medicine and pharmacy in france. the most represented motives will be analyzed on the questionnaire of motivations for consumption (threshold frequency ≥20%). the secondary objectives are to identify the risk factors linked to the individual, to the environment and to drugs in students with pad use disorders regardless of their motivation and in those using to improve their performance.


Eligibility criteria:
inclusion criteria: * being of legal age * studying medicine or pharmacy in france from the 2nd to the 6th year * have read the newsletter and validated its no objection * have answered all the questions * validate the return of the questionnaire exclusion criteria: * partial filling of the online questionnaire
fred retrospective study of intracranial aneurysms treatment

Conditions: Intracranial Aneurysm

Summary: to evaluate the long-term safety and efficacy of flow re-direction endoluminal device system (fred) in the treatment of intracranial aneurysms in the post-market environment

study objective: to evaluate the long-term safety and efficacy of flow re-direction endoluminal device system (fred) in the treatment of intracranial aneurysms in the post-market. study design: post-market, retrospective, multi-center, observational clinical study study population: patient who has implanted at least one observational device in china mainland.

Eligibility criteria:
inclusion criteria: * people in china mainland who have been treated with fred. the patients for whom clinical data are available exclusion criteria: * patients who met the inclusion criteria at all time points were required to be included in the study. therefore, no specific exclusion criteria were set.

Keywords: intracranial aneurysms
short against long antibiotic therapy for infected orthopedic sites

Conditions: Orthopedic Devices Associated With Misadventures; Infection, Surgical Site; Antibiotic Side Effect

Summary: the investigators will perform two concomitant rcts, depending on the presence of infected osteosynthesis material at enrolment: - salatio 1. infected implant not removed (or new material inserted): randomization 6 vs. 12 weeks (+/- 5 days) of total antibiotic therapy counted since the first debridement for infection. early switch to oral targeted therapy. - salatio 2. infected implant without residual material (definitive removal or within the interval of a two-stage exchange): randomization 3 vs. 6 weeks (+/- 5 days) of total antibiotic therapy counted since the first debridement for infection. early switch to oral targeted therapy.

the optimal duration of postoperative, systemic antibiotic therapy for implant-related orthopedic infections, with or without implant removal, is unknown. retrospective studies suggest that a maximum duration of 6 weeks is not inferior to longer administrations; even if the infected implants are kept in place or during a one-stage exchange. prospective-randomized trials (rct) suggest that even shorter durations, such 3 or 4 weeks, are possible, when the implant is removed. likewise, in prospective studies, 6 or 8 weeks of systemic antibiotics are not inferior to the current 12 weeks during dair (debridement, antibiotic and implant retention), or during the one-stage exchange; except for one single rct suggesting a better outcome for 12 weeks in the substrata of arthroplasty infections undergoing the dair procedure. however, these rcts concern selected branches of orthopedic surgery; especially prosthetic joint infections. the investigators intend to expand these evaluations to all fields of orthopedic and hand surgery. the only exceptions would be spine surgery, for which a multicenter, separate rct is already under way (sasi-trials). the second exception would be the treatment of implant-free diabetic foot infections, for which two rcts are underway.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years on admission * orthopedic bone and implant infections including musculoskeletal grafts * intraoperative debridement with any surgical technique * 12 months of scheduled follow-up from hospitalization * bacterial orthopedic infections of any nature * first or second episode of infection exclusion criteria: * mycobacterial, fungal, nocardial, and actinomyces infections * purely soft tissue infections * non-resected cancer in the infection site * purely intrasynovial infections (native joint septic arthritis) * more than three debridements performed for infection * absence of at least one surgical intraoperative debridement * spine infections (investigated in another trial)10 * diabetic foot infections (investigated in another trial)7 * documented endocarditis according to the duke criteria * at least 2 prior infection episodes at the actual infection site

Keywords: orthopedic infectionst duration antibiotic therapy randomized-controlled trial