Kornimate/medical-research-clean huggingface dataset:
sbrt for oligo-metastatic lesions after systemic treatment of primary metastatic nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma; Metastasis; Stereotactic Body Radiation Therapy

Summary: primary metastatic npc patients received chemotherapy± immunotherapy, radiation for primary tumors and sbrt for metastatic lesions.

the eligible patients will receive 4-6 cycles chemotherapy±immunotherapy and radical radiotherapy for nasopharyngeal tumors. then, sbrt for oligometastatic lesions will be assigned to eligible patients. the efficacy and side-effect will be evaluated and analyzed. the relation of liquid biopsy data with treatment outcome（such as ebv dna, ctcs, ctc subtype，pd-l1 and so on）will be valued.

Eligibility criteria:
inclusion criteria: * histologically conformed initial metastatic non-keratinizing nasopharyngeal carcinoma (according to the 8th edition of ajcc/uicc stage system) and no pd was observed in eligible patients after comprehensive treatment (chemotherapy±immunotherapy+radiotherapy to primary tumor). then, the metastic lesions were pr/sd, and met the following requirement: the metastatic lesions ≤5 and metastatic organs ≤2, no more than 3 metastastic lesions for a single organ (diameter ≤ 5cm) * age 18-70 years old * karnofsky scores ≥70 * estimated life ≥ 6 months * adequate organ function including the following: absolute neutrophil count (anc) \>= 2.0 \* 109/l; platelets count \>= 100 \* 109/l ;hemoglobin \>= 90 g/dl; creatinine clearance \>= 60 ml/min; for patients without liver metastasis, ast and alt \ 700 ml * signed written informed consent exclusion criteria: * patients who achieve complete remission after comprehensive treatment * pathology confirmed as second primary tumor * received radiotherapy at the corresponding site before, and overlapped with the site of this radiotherapy * femoral bone metastasis * with serious medical complications and contraindications of radiotherapy * with uncontrollable malignant pleural effusion * positive pregnancy test for women of childbearing age or lactating women * uncontrolled or active infections, such as immunodeficiency or hiv infection * active mental disorder or other mental disorder that affects the patient's ability to sign informed consent and understanding.
clinical comparison of ddt2 contact lens and a daily disposable contact lens - study 2

Conditions: Refractive Error; Myopia

Summary: the purpose of this study was to evaluate visual acuity at distance when wearing ddt2 contact lenses compared to clariti contact lenses.

subjects were expected to attend 3 study visits and wear the ddt2 and clariti study lenses in a crossover design for approximately 14 - 20 days (7 - 10 days for each product).

Eligibility criteria:
key inclusion criteria: * able to understand and sign an informed consent form that has been approved by an institutional review board. * willing and able to attend all scheduled study visits as required per protocol. * current wearer of spherical soft contact lenses. key exclusion criteria: * any ocular condition that contraindicates contact lens wear. * previous or current habitual wearer of clariti® or dailies total1® contact lenses.

Keywords: visual acuity va daily disposable contact lenses
application of early goal-directed sedation in patients with severe brain injury

Conditions: Brain Injuries, Traumatic

Summary: egds management strategy was implemented in icu patients with severe brain injury, the depth of sedation and gcs score were monitored, and the protective effects of egds strategy and standard sedation strategy on the brain of patients with severe brain injury were discussed.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of severe craniocerebral injury * the gcs score is 6 to 12 points * within 12 hours of intubation * the mechanical ventilation time is greater than 24 hours * obtain written consent exclusion criteria: * pregnant women * acute liver failure * dementia or mental illness

Keywords: brain injuries early goal-directed sedation
karenitecin versus topotecan in patients with advanced epithelial ovarian cancer

Conditions: Ovarian Cancer

Summary: the objective of this study is to assess the safety and efficacy of karenitecin versus topotecan in patients with platinum/taxane-resistant advanced epithelial ovarian cancer. additionally, this study will assess the ability of karenitecin to extend the time to disease progression, extend the overall survival time, and reduce the incidence and severity of treatment related hematological toxicities in patients with advanced epithelial ovarian cancer.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * confirmed diagnosis of stage iii or iv epithelial ovarian cancer * have cancer that is resistant to platinum/taxane-based chemotherapy regimens * have measurable, progressive disease * have an ecog ps ≤ 2 exclusion criteria: * have uncontrolled high blood pressure, uncontrolled diabetes mellitus, or other serious underlying medical condition not compatible with study entry. * have a life expectancy \< 3 months * received prior treatment with a camptothecin (topotecan, cpt-11, or investigational camptothecins). * received prior treatment with any platinum agent other than cisplatin or carboplatin. * received prior radiation therapy to greater than one-third of the hematopoietic sites (one-third of the pelvis and axial skeleton combined).

Keywords: ovarian cancer advanced ovarian cancer
hitt for the identification of mild traumatic brain injury

Conditions: Brain Injuries, Traumatic

Summary: rebion has developed a device, the rebion trauma tool (referred to as the head and intraocular trauma tool, or "hitt"), that detects ocular fixation and alignment using a binocular retinal scan. preliminary data obtained from hospitalized patients with a clinically-confirmed traumatic brain injury (tbi) and uninjured controls indicates that the device can detect changes in ocular fixation, alignment, and saccades that are related to brain injury. this study seeks to evaluate the ability of the rebion trauma tool to assess perturbations in eye movements resulting from tbi. the study will enroll 100 tbi patients and 100 controls.


Eligibility criteria:
inclusion criteria: 1. age 13-45 years 2. presents to the facility within 2 weeks of head trauma 3. able to provide informed consent * if minor, then able to provide parental consent and minor assent 4. able to participate in the examination, including the ability to follow simple instructions 5. fluency in english or spanish exclusion criteria: 1. glasgow coma scale score of equal to or less than 13 at the time of study enrollment 2. under the influence of alcohol or drugs 3. previous eye surgery 4. visual acuity known to be 20/200 or less in either eye 5. known strabismus, amblyopia (lazy eye), or double vision 6. known eye movement disorder, including nystagmus 7. known optic nerve disease, including papilledema or optic neuropathy 8. known retinal disease, including macular degeneration or retinal degeneration 9. known cataract 10. history of neurosurgery 11. history of stroke/brain hemorrhage, brain tumor, or epilepsy 12. any head trauma requiring medical attention from a physician within the last 6 months 13. diagnosed dementia or cognitive impairment requiring assistance for daily living 14. other condition(s) under the care of a neurologist 15. psychiatric hospitalization in the last 90 days 16. subject considered unsuitable for participation in this clinical trial by pi, treating clinician, or study research staff 17. any minor brain injury regardless of loss of consciousness
psychological impact of medical evacuations on families of patients admitted to intensive care unit for severe covid-19

Conditions: COVID-19; Stress Disorders, Post-Traumatic

Summary: at the "métropole savoie" hospital, to deal with the daily influx of severe patients during the second wave of covid-19, 23 patients had to be transferred away from their home city and far from their families as part of a medical evacuation (evasan). the purpose of the study is to investigate whether there is an association between medical evacuations and the occurrence of psychological disorders such as post-traumatic stress, anxiety or depression occurring within 6 to 10 months in families of evacuated patients. the investigators want to compare the prevalence of psychological disorders in the families of patients evacuated for a serious form of covid-19 (cases) compared to that of families of patients not evacuated (controls) hospitalized for a serious form of covid-19.

the case group is trusted person of evacuated patient. the control group is trusted person of not evacuated patient. the trusted person of the group control will be matched to trusted patient of the case group on : their relationship with the patient (spouse/ascendant/descendant/other) and on criteria specific to the patient: sex, age range ( \<75 years or ≥ 75 years), invasive ventilation and becoming at 3 months post covid-19 (survivor / non survivor)

Eligibility criteria:
inclusion criteria: trusted person of patients admitted to the adult intensive care unit (icu) of the "metropole savoie"hospital * during the second wave of covid-19 in france * for a serious form of covid-19 * hospitalized more than 72 hours in icu the case group is trusted person of evacuated patient. the control group is trusted person of not evacuated patient. non -inclusion criteria : trusted person refusing patient medical evacuation
apolipoprotein (apo)e genotype, meal fatty acids, postprandial lipaemia

Conditions: Cardiovascular Disease

Summary: cardiovascular disease (cvd) is the greatest cause of morbidity and mortality in the uk. abnormalities in the concentration and/or composition of lipoproteins (the lipid carrying particles), in particular low density lipoproteins (ldl) in circulation, is one of the most important physiological defects contributing to the development of cvd. the ldl cholesterol (ldlc) response to fatty acid change is in part mediated by the apoe genotype, with e4 individuals (25% of the uk population) being most responsive to changes in dietary fats, showing greater reductions when low levels of saturated fats or fish oils are consumed and greater increases when high levels of these fats are consumed. therefore the aims of the present study is to understand the mechanism that regulates the higher ldlc response associated with saturated fatty acids and fish oil consumption in healthy men prospectively recruited based on their apoe genotype.


Eligibility criteria:
inclusion criteria: * gender male * age 18-70 years * body mass index (bmi) \< 32 kg/m2 * plasma triglycerides 1-4 mmol/l * plasma cholesterol \< 8 mmol/l * glucose \< 7 mmol/l * haemoglobin \> 11 g/dl * apoe e3/e3, e3/e4 exclusion criteria: * blood pressure \> 200/95 mmhg * had suffered a myocardial infraction or stroke in previous 2 years. * diabetes mellitus * liver disease * other endocrine disorders * unstable angina * familial hyperlipidaemia * any dietary restrictions or an a weight reducing diet * on fatty acid supplements e.g. evening primrose oil or fish oils * vigorous exercise e.g. competitive athletes * apoe2/e2, apoe2/e3 and apoe2/e4 * any other parameter on which the investigators felt an individual was unsuitable

Keywords: fatty acids cardiovascular disease genotype apoe
cannabidiol effects on learning and anxiety

Conditions: Anxiety and Fear

Summary: to examine the extent to which cannabidiol (cbd) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety. undergraduates who display elevated social anxiety on standard assessments will be recruited at the university of connecticut. all participants will be put in a standard fear conditioning paradigm where they are conditioned to fear a face that occasionally is followed by a shock to their wrist. the other face never is paired with a shock. after everybody learns this, half of the participants will receive 600 mg cbd isolate gel capsules one time, and the other half will receive a placebo dose. participants will then be presented with the faces with no shocks, and the rate and duration of extinction as measured by electrodermal response as well as subjective fear ratings via a visual analogue scale will be examined. it is hypothesized that participants that receive cbd will display enhanced extinction compared to the placebo group, as evidenced by reduced electrodermal response and reduced visual analogue fear ratings.


Eligibility criteria:
inclusion criteria: * 18-50 years of age exclusion criteria: 1. difficulties seeing a computer screen 2. anyone currently taking cbd within the last 24 hours. 3. anyone using any cannabis product within the last 24 hours. 4. heart problems or heart disease 5. a neurological disorder such as epilepsy, stroke, multiple sclerosis, tumor, vascular malformations, aneurysm 6. are currently pregnant or breast-feeding

Keywords: social anxiety fear conditioning cannabidiol electrodermal response
st36 acupoint injection with anisodamine for postoperative nausea and vomiting

Conditions: Postoperative Nausea and Vomiting

Summary: postoperative nausea and vomiting (ponv) is particularly distressing although it is not a fatal postoperative complication. numbers of studies have been focused on identifying risk factors and therapies of ponv. unfortunately, there' no consistent comments for ponv prevention in women after laparoscopic sleeve gastrectomy. notably, zusanli (st36) acupoint and anisodamine have been evidenced to treat various gastrointestinal conditions. the primary outcome of this study was to evaluate the impact of anisodamine injection in st36 on ponv in women following bariatric surgery.

acupuncture has been used as a medical technique in china for at least 2,000 years. more recently, it's also been extensively used in managing headache, chronic back pain, and ponv in usa. st36 acupuncture is reported to be an effective preventive treatment for postoperative nausea and vomiting (ponv). however, it is not clear if it could efficiently prevent ponv in female patient who has underwent bariatric surgery. at the onset of this investigation, we have already identified several methodologic issues, such as the timing of the acupuncture intervention, sample size, perioperative anesthetic techniques, and appropriate control groups. the primary outcome of this study was the total incidence of ponv during the hospital and after the discharge. participants were randomly assigned into different groups according to the with a computer-generated randomization sequence (http://www.randomization.com). patients, surgeons, anesthesiologists, nursing staff, and the research assistant, were all blinded to the group assignment.

Eligibility criteria:
inclusion criteria: 1. female patients with an american society of anesthesia (asa) physical status ⅰ-ⅲ 2. scheduled for elective bariatric surgery . exclusion criteria: 1. lack of patient consent 2. patients with contraindications for acupoint injection 3. obesity due to endocrine disorder 4. allergic diathesis for drugs used in the study 5. serious illness (heart, lung, kidney, or liver) 6. coagulation dysfunction 7. pre-existing psychological disorder 8. anticathartic , glucocorticoid or opiates medications

Keywords: postoperative nausea and vomiting bariatric surgery zusanli (st36) anisodamine
paclitaxel eluting balloon application in sfa in stent restenosis

Conditions: Peripheral Arterial Disease

Summary: nowadays, stenting is became a standard of care in revascularization for superficial femoral artery (sfa) atherosclerotic lesions. however, the achilles' heel of this technique remains in-stent restenosis (isr). while most of local therapies have failed to demonstrate significant benefit, studies for the treatment of sfa isr are lacking and percutaneous transluminal angioplasty remains the current standard of care for this indication. recent studies have shown successful results of drug eluting balloon in the treatment of sfa de-novo lesions and of coronary isr. freeride, a french prospective cohort has been set up to evaluate the safety and the efficacy of drug eluting balloon (deb) for the treatment of sfa atherosclerotic lesions.


Eligibility criteria:
inclusion criteria: * age ≥18 years old * symptomatic patient according to rutherford class 1, 2, 3, 4 or 5 * clinical degradation by at least 1 rutherford stage or absence of healing of all skin lesions * symptoms related to sfa isr defined by psvr \> 2.4 within 3 to 24 months after sfa stenting of de novo atherosclerotic lesions. each patient may have either one or both limbs treated in the study * the target isr lesion is fully comprised between the origin of the sfa and distally the femoropopliteal crossover (crossing by sfa of medial rim of femur in the pa projection) * adequate sfa inflow and outflow either pre-existing or successfully re-established (outflow defined as patency of at least one infragenicular artery) * the target lesion must no extend beyond the stent margin * successful crossing of the target lesion, inflow and outflow lesions with a guidewire * patient belongs to the french health care system * written informed consent exclusion criteria: * no atheromatous disease * asymptomatic lesion * known allergies to heparin, aspirin, other anti-coagulant/antiplatelet therapies, and/or paclitaxel * acute limb ischemia * patient on oral anticoagulation therapy * target lesion requires / has been pre-treated with alternative therapy such as: des, laser, atherectomy, cryoplasty, cutting/scoring balloon, etc. * life expectancy \< 1 year * patient involved in another trial * refusing patient * pregnancy

Keywords: superficial femoral artery endovascular drug eluting balloon paclitaxel
safety and efficacy of enhanced recovery after surgery in neurocritical care

Conditions: Neurocritical Care; Traumatic Brain Injury; Cerebrovascular Disease; Moderate or Severe Coma

Summary: enhanced recovery after surgery (eras) is a strategy of perioperative management aimed to accelerate the rehabilitation of patients through various optimized perioperative managements as well as ongoing adherence to a patient-focused, multidisciplinary, and multimodal approach. alleviating the injury and stress caused by surgery or disease is the core principle of eras, which has been shown to reduce complication rates after surgery, promote patient recovery, decrease hospital length of stay and reduce costs. eras has been widely applied in many surgical perioperative fields, and it has achieved remarkable effects. however, there are few applications of eras in neurosurgery, especially in clinical trials of neurocritical care patients. therefore, the investigators attempt to conduct the study of eras in neurosurgical intensive patients using a series of optimized perioperative managements that have been verified to be effective by evidence-based medicine, and to evaluate the safety and effectiveness of eras in neurocritical care. the aim of this study is to explore the most suitable eras protocols to accelerate the postoperative rehabilitation process of neurocritical care patients, and to provide more evidence-based medicine for the effectiveness and safety of eras in neurosurgery.


Eligibility criteria:
inclusion criteria: * age 18-75 years old * patients with moderate or severe acute traumatic brain injury or cerebrovascular disease requiring neurosurgical intensive care treatment * hospitalization time ≥ 1 week * the guardian is able to understand and actively cooperate in completing the project * the guardian signs an informed consent form exclusion criteria: * patients undergoing non-surgical treatment * patients diagnosed as brain death within the first 24 hours after admission to nicu * patients undergoing cardiopulmonary resuscitation, maintenance dialysis, end-stage tumors, and disseminated cancer * patients who withdraw treatment during hospitalization or are discharged automatically * patients who underwent unplanned secondary surgery during the research process * individuals who cannot be followed up during the research process

Keywords: neurocritical care traumatic brain injury cerebrovascular disease
impact of metformin in rectal cancer patients

Conditions: Rectal Cancer Patients

Summary: design: prospective, randomized controlled clinical trial setting: at minia university hospital and minia oncology institute. condition: colorectal cancer. to be eligible for participation, patients must meet the following criteria: 1. histologically confirmed diagnosis of rectal adenocarcinoma. 2. age starting from 18 and older. 3. eastern cooperative oncology group (ecog) performance status of 0-2. 4. adequate organ function (renal, hepatic, and hematological) 5. signed informed consent. patients will be randomized into two groups: group a: patients will receive standard chemoradiotherapy(crt). group b: patients will self-administer 1000mg of metformin twice daily by mouth: 1. beginning 1-2 weeks before standard crt. 2. during standard crt. 3. until 30 days after the end of standard crt.


Eligibility criteria:
inclusion criteria: 1. histologically confirmed diagnosis of rectal adenocarcinoma. 2. age starting from 18 and older. 3. eastern cooperative oncology group (ecog) performance status of 0-2. 4. adequate organ function (renal, hepatic, and hematological) 5. signed informed consent. exclusion criteria: 1. metastatic disease. 2. contraindications to metformin. 3. significant comorbidities or medical conditions that may interfere with study participation. (d.m, pco,..) 4. egfr less than 30 ml/min. 5. pregnant or breastfeeding women.

Keywords: metformin complete pathological response rectal patient neoadjuvant chemoradiotherapy
effects of core strengthening and pnf pattern on balance and plantar pressure in chronic stroke

Conditions: Stroke; Paralysis

Summary: to compare the effects of core strengthening and pnf on standing balance and plantar pressure in chronic stroke patients

the effects of different exercise regimes and pnf techniques on balance and plantar pressure had been studied. this study focuses on determining the effects of cse and pnf techniques on developing static standing balance and plantar pressure in stroke patients using podata

Eligibility criteria:
inclusion criteria: * • age 45-60 * score of 9 or higher on the static component of berg balance scale * both genders will be recruited. * first ever episode of stroke * duration of stroke greater than 6 months. * having a score of equal to or less than 2 on the modified ashworth scale * having a score of greater than or equal to 24 on the mini-mental state examination in order to understand the commands. exclusion criteria: * • concurrent orthopedic (for e.g. amputation ) that may hamper standing * relevant psychiatric disorders that may prevent from following instructions. * other medical drugs that may influence our intervention * condition contraindicating physical activity * use of cardiac pacemakers.

Keywords: stroke, static balance, pnf, plantar pressure, podata