Kornimate/medical-research-clean huggingface dataset:
the role of hexamidine diisethionate (zamidine®) 1mg/ml 0.6ml eye drops in the prophylaxis of surgery oftalmic

Conditions: Eye Disease; Conjunctivitis

Summary: data will be gathered from patients who report having any kind of recurrent conjunctivitis and who, in accordance with clinical practice, are scheduled to have intravitreal injections, glaucoma surgery, cataract surgery, vitrectomy, combined cataract and vitrectomy, or corneal transplantation. the data will be obtained using pseudonyms from the patients' medical records and will include the outcomes of swabs and surgeries performed in accordance with clinical practice for the patient's condition. the following swabs will be taken into consideration for data analysis: four days before to surgery, a conjunctival swab is used to check for the presence and load of species that do not make up the typical conjunctival flora (baseline-t0). on the day of operation, a conjunctival swab is taken before to entering the recovery room (t1). following three minutes of 5% iodopovidone instillation in the eye to be operated on, a conjunctival swab (t2) was used. additionally, we will gather follow-up data from the medical record 24 and 30 hours after surgery (at day 34 +/- 7 days).

to determine if zamidine® reduces ocular surface bacterial flora in surgical prophylaxis. secondary goals. to quantify and qualitatively evaluate ocular surface bacterial flora, * compare bacterial load before and after surgery with 5% iodopovidone. * determine sample endophthalmitis incidence. the study will include patients who are scheduled for intravitreal injections, glaucoma surgery, cataract surgery, vitrectomy, combined cataract and vitrectomy, corneal transplantation, and any type of recurrent conjunctivitis. data from patients' medical records will be pseudonymized and contain swabs and operation findings according to clinical practice for their condition. following swabs will be analyzed for data: - a conjunctival swab four days before surgery to detect and quantify non-native organisms. a conjunctival swab before operation day's recovery room (t1). - a conjunctival swab (t2) after 3 minutes of 5% iodopovidone in the operative eye. follow-up data at 24 and 30 days after surgery (day 34 +- 7 days) will be collected from the medical record.

Eligibility criteria:
inclusion criteria: 1. age 18 years or older, male and female; 2. patient requiring ophthalmic surgery (intravitreal injections, glaucoma surgery, cataract surgery, vitrectomy, combined cataract and vitrectomy, corneal transplantation) and in need of antiseptic surgical prophylaxis (e.g., zamidine®) 3. positive history of recurrent conjunctivitis in the eye requiring surgery. 4. written informed consent. exclusion criteria: 1. age \< 18 years; 2. refusal to give informed consent.

Keywords: ophthalmic prophylaxis surgery ophthalmic swab
estrogen, diabetes, and endothelial function

Conditions: Type 1 Diabetes

Summary: this study planned to learn more about women and how the drop in estradiol levels during menopause may affect their cardiovascular risk. with aging, the arteries that are located around the heart get stiffer, and this increase in arterial stiffness can lead to a number of health problems such as high blood pressure and heart disease. in this study, the investigators examined whether a short-term drop in estrogen levels caused arteries to become stiffer, and explored potential reasons for stiffening arteries.

participants completed two study visits. the baseline study visit occurred during the early follicular phase of the menstrual cycle, confirmed via take-home ovulation testing. on the day of the baseline study visit, all participants underwent ovarian sex hormone suppression with gnrhant therapy (cetrorelix acetate, 0.25 mg/day) delivered daily as subcutaneous injections for a 1-week period. participants were randomized to one of two concurrent intervention groups: transdermal estradiol patch (0.075 mg/day) (+e2) or placebo patch (+pl) and returned for a follow-up visit after 1 week of the intervention. both study visits included collection of anthropometric measures, a fasting blood sample, measures of arterial stiffness, flow-mediated dilation, and endothelial cells via an intravenous catheter.

Eligibility criteria:
inclusion criteria: * premenopausal * euthyroid * not currently planning to become pregnant * not currently breastfeeding * no recent history of amenorrhea in the previous 6 months * consent to data and specimen banking * no use of hormonal contraceptives inclusion criteria, type 1 diabetes only: * diagnosis of type 1 diabetes for at least 5 years * on insulin within a year of diagnosis * current insulin therapy * hemoglobin a1c \< 9.5% * no macroalbuminuria (aer \< 200 ug/min) inclusion criteria, non-diabetic controls only: * hemoglobin a1c \< 5.7% exclusion criteria: * pregnant and/or breastfeeding * have not had a menstrual cycle in the last 6 months
anti-inflammatory therapy following selective laser trabeculoplasty

Conditions: Primary Open Angle Glaucoma; Pseudoexfoliation Glaucoma

Summary: the type of anti-inflammatory medication used post selective laser trabeculoplasty (slt) may have an impact on the intra-ocular pressure (iop) lowering effect of slt. this study will evaluate the iop lowering effect of slt following the topical administration of one of the following: prednisolone 1%, ketorolac 0.5% or artificial tears.

patients who have been chosen to undergo slt for glaucoma will be randomized to receive one of prednisolone 1%, ketorolac 0.5% or artificial tears four times a day for 5 days following administration of the laser treatment. the iop will be measured at various time points following slt: 1 hour, 2 days, 1 week, 1 month, 3 months, 6 months, and 1 year.

Eligibility criteria:
inclusion criteria: * primary open angle glaucoma, pseudo exfoliation glaucoma exclusion criteria: * previous incisional glaucoma surgery

Keywords: primary open angle glaucoma pseudoexfoliation glaucoma selective laser trabeculoplasty intra ocular pressure anti-inflammatory therapy prednisolone acetate 1% ketorolac tromethamine 0.5%
alpha-bisabolol gel with antihistamine action

Conditions: Wounds and Injuries

Summary: it will be developed and evaluated the antihistamine potential of a gel containing alpha-bisabolol. method: interventional and cross-sectional study, with convenience sampling, conducted with 20 volunteers. the forearm will be sensitized at four points (a, b, c and d). point a: positive control will be sensitized with a drop of histamine at a concentration of 10 mg / ml. point b: histamine will apply and immediately after, the alpha bisabolol gel with a concentration of 0.5%. point c: histamine and gel with 2.5% alpha-bisabolol will apply. point d will be sensitized with a drop of histamine and 5.0% alpha-bisabolol gel. the test reading at each point will occur 15 minutes after the procedure. for the analysis of the results, the t test will be applied.

context:. phytotherapy has been widely used to treat health with a prophylactic, curative and palliative purpose due to its easy access and low cost when compared to other available drug forms. some plant species have antiallergic and anti-inflammatory properties that can be used to help contain signs and damage in allergic reactions, triggered mainly by histamine such as: pain, redness, heat and edema. alpha-bisabolol, extracted from candeia, has several applications in the treatment of illnesses, however, there are no studies on the therapeutic potential for antihistamine. objective: to develop and evaluate the antihistamine potential of a gel containing alpha-bisabolol. method: pilot study, interventional, cross-sectional study, with convenience sampling, conducted with 20 volunteers. the forearm will be sensitized at four points (a, b, c and d). point a: positive control sensitized with a drop of histamine at a concentration of 10 mg / ml. point b: histamine will be applied and immediately after, the alpha bisabolol gel with a concentration of 0.5%. point c: histamine and gel with 2.5% alpha-bisabolol will be applied. point d will be sensitized with a drop of histamine and 5.0% alpha-bisabolol gel. the test reading at each point will occur 15 minutes after the procedure. for the analysis of the results, the t test will be applied.

Eligibility criteria:
inclusion criteria: * participants without allergy-related diseases, non-pregnant women and who agreed to cooperate in carrying out the research by signing the consent form aged between 18 and 60 years of both sexes. exclusion criteria: * participants who had a history of previous anaphylaxis, extensive dermatitis, use of antihistamines, colds or steroids. * participants who had a negative reaction to histamine and/or withdrew their consent at any stage of the study.

Keywords: histamine antagonists phytotherapy wounds and injuries bites and stings plant oils
adductor strength in roller hockey athletes

Conditions: Groin Pain

Summary: roller hockey athletes will be recruited along the season and will be examined for adductor strength and other potential groin pain risk factors.

roller hockey athletes will be recruited and assess through the season. the assessment consist of an adductor, abductor strength measurement, hip and groin outcome score (hagos) completion and will be screened for other risk factors which are believed to cause groin pain (age, previous injury)

Eligibility criteria:
inclusion criteria: * participate in the roller hockey bronze division from spain exclusion criteria: * deny participation

Keywords: roller hockey groin pain risk factors
the investigation of the impact of early mobilization on the outcome in patients with aneurysmal subarachnoid hemorrhage.

Conditions: Early Ambulation; Standard of Care; Subarachnoid Hemorrhage, Aneurysmal

Summary: the goal of the randomized clinical trial is to examine the effect of early mobilization on primary and secondary outcomes in patients with subarachnoid hemorrhage caused by aneurysm rupture. researchers will compare early mobiliziation vs. standrad bed rest care.


Eligibility criteria:
inclusion criteria: * age \>18 ys * premorbid modified rankin scale score of 0-2 * wfns i-iv at enrollment * aneurysm occlusion has occurred through open or endovascular means * minimum 24 hours elapsed after aneurysm occlusion * the patient has not received thrombolytic therapy * vital parameters are appropriate (mean arterial pressure \[map\] \>80 or \>110 mm hg) * signed patient information and consent form * enrollment occurs within 72 hours following ictus exclusion criteria: * age under 18 years * traumatic subarachnoid hemorrhage * incapacitated or limited capacity for action before ictus * confirmed pregnancy * aneurysm multiplicity (unless all aneurysms are treated)

Keywords: subarachnoid hemorrhage early mobilization
assessment of the benefit of teleconsultations for children with autism spectrum disorders

Conditions: Autism Spectrum Disorder; Child Autism

Summary: the purpose of this study is to determine whether teleconsultation would a)be effective and cost-effective by increasing the proportion of patients with autism spectrum disorders having a correct follow-up, and less transportation, and b) get a high satisfaction from the parents and from the professionals


Eligibility criteria:
inclusion criteria: * all residents of medico-social structures accepting children and adolescent with autism disorders exclusion criteria: * refusal of parents that their child use telemedicine * refusal of parents that their child participate to the research

Keywords: telemedicine health economics
canderel:effects on blood glucose concentration and appetite scores

Conditions: Appetitive Behavior; Glucose Metabolism Disorders

Summary: this study investigates the effects of canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores.

the study is separated into two parts: a) investigating the effects of artificial sweeteners in combination with complex carbohydrates; and b) investigating the effects of artificial sweeteners in combination with simple sugars. a) participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the canderel drink (3g of canderel dissolved in 250ml of water) alongside an isocaloric high carbohydrate breakfast. blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast. b)participants will be randomly given either the placebo drink (3g of lyle's golden syrup and 3g of maltodextrin dissolved in 250ml of water) or the canderel+sugars drink (3g of canderel and 3g of lyle's golden syrup dissolved in 250ml of water) . blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after drink

Eligibility criteria:
inclusion criteria: * healthy male and female adults (18-64) exclusion criteria: -

Keywords: blood glucose appetite
platelet and red blood cell volume indices as inflammatory biomarkers in ankylosing spondylitis

Conditions: Ankylosing Spondylitis

Summary: this study aims to determine the relatioships among the nlr ,plr ,mlr ,red cell volume and platelet volume indices levels as biomarkers in ankylosing spondylitis.


Eligibility criteria:
inclusion criteria: * patient with disease duration of more than 6 months * age more than 18 years exclusion criteria: * patient with cardiac ,cerebrovascular and hematologic diease * ptient with hypertension ,diabetes ,metabolis syndromes and other autoimmune rheumatic diseases.
effect whole body vibration on balance in post diabetic menopause women

Conditions: Diabetic Peripheral Neuropathy; Postmenopausal Women

Summary: postmenopausal diabetic women have significant balance deficits and increased fall risk. whole-body vibration may improve balance in these population but needs further research. the purpose of the current study was to determine the effect of whole-body vibration on balance in postmenopausal diabetic women.

background: menopause is characterized by reduced androgens produced by ovaries, which negatively affect women health including metabolism and quality of life (qol) and sexual function. purpose: this study investigates the effect of whole-body vibration on balance and qol in postmenopausal diabetic women. methods: forty postmenopausal women with diabetic neuropathy will participate in this study aged from 50 to 65 years. they will be randomly distributed into two equal groups: group a (study group): will receive whole body vibration (wbv) and balancing exercise. group b (control group): will receive the same balancing exercises as group a. the treatment will be performed 3 times per week for 12 weeks. dynamic balance will be assessed by biodex balance system (bbs) that assesses (overall stability index \[osi\], anteroposterior stability index \[apsi\] and mediolateral stability index \[mlsi)\], berg balance test (bbt) and time up and go test (tug). quality of life will be assessed by menopous specific in quality of life questionnaire before and after the treatment.

Eligibility criteria:
inclusion criteria: * inclusion criteria: patients were examined by a gynaecologist before the study and were selected according to the following criteria: * diabetic postmenopausal women who suffered from peripheral neuropathy * their ages ranged from 50 to 65 years. * body mass indices (bmi) ≤ 30kg/m2 * they were medically stable. exclusion criteria: * patients were examined by a gynaecologist before the study and were excluded if they had: * inner ear disturbance. * musculoskeletal problems. * active tuberculosis and tumours. * implanted cardiac rhythm devices. * any hormonal replacement therapy or drug treatment that could affect normal metabolism of musculoskeletal system. * habitual exercise or participate in any supervised exercise. * hypo- or hyperparathyroidism, renal, liver, or chronic disease.

Keywords: balance quality of life whole body vibration diabetes postmenopausal
impact of a procedure with socio-aesthetic care on anxiety and pain scale in the early rest of pulmonary transplant.

Conditions: Pulmonary Transplant

Summary: pulmonary transplant is a valid therapy and now accept in some case of respiratory disease at final state of their evolution in selected patients according to morbidity associated. this exceptionnal procedure (+/- 350 patients per year) brings benefits in terms of survival and quality of life but stay nevertheless, an experience very gruelling, anxiogenic and painful with sometimes extend hospitalizations in intensive care and then in pneumology unit. transplant can generate several complications like infection or rejection which can be fatal. the rate of death a year after the transplant is around 27% and whom 5 years after is around 48% according biomedicine agency, 2016) it's also mar of physical consequences (pain, scrars) specific to this act and expose the patient to several psychologic disruptions (decrease of body reflect, difficulty to accept organ of an other person...) so post transplant period is a painful and frightening moment. however, fear is not only sensory, it's also an affective side involving unpleasant feelings, fear and anxiety. it's a subjective and personnal experience influenced by the culture, context and other psychologic variables. the collateral effects of transplantation could be controlled through additionnal diverse comfort cares but no care protocoles can be validated, especially because of multiple confounding individuals factors. recent studies showed that socio-aesthetic care allow an improvment of pain perception after cardiac surgery or oncology treatment. the investigators propose to evaluate by a randomized controlled study the effect of comfort care of socio-aesthetic type on anxiety and pain in the aftermath of a pulmonary transplant. in their hypothese, comfort care as socio-aethetic (body care, massage, manicure, corrective make up) could bring a personnalized answer to these patients, adapting to their complaint and waiting. it could ease the pain, anxiety, decrease level of corrective care and their side effects. in their study, socio-aesthetic care will be done by therapist with 15 years of experience and working since 2003 in the oncology unit at la timone hospital and since 2009 to psychiatry unit to la conception hospital


Eligibility criteria:
inclusion criteria: * \>18 years old * patient transfered in respiratory unit (hôpital nord, aphm) immediate following lung transplant * person affiliated with a social security system exclusion criteria: * patient refusing post transplant following until 6 months * history of skin allergy * persons deprived of their liberty, persons under guardianship or trusteeship, persons in an emergency * person not affiliated to a social security system or not entitled to
caffeine use in prolonged oxygen use in meconium aspiration syndrome in neonatal outcomes (capucino)

Conditions: Meconium Aspiration Syndrome

Summary: when babies are stressed in the womb, they sometimes pass meconium in the amniotic fluid. when this happens, they may swallow the meconium-stained fluid into their lungs which may cause them to have poor oxygen levels and require resuscitation and significant breathing support in the early hours after birth. this is referred to as meconium aspiration syndrome (mas). some babies may recover slowly and require breathing and/or oxygen support for days. caffeine is a drug that can help improve breathing efforts and is commonly used in premature babies who do not have regular or strong breathing efforts. caffeine has been used in babies with mas who recovered slowly (i.e. requiring breathing or oxygen support for a longer period) for several years now. despite having success in many babies, there is no evidence to examine its effectiveness and mechanism of action. this pilot study proposes to look at the effects of caffeine in babies with mas who require ongoing breathing and oxygen support. there will also be examination of whether caffeine improves breathing efforts with better lung opening using ultrasound images of the lungs.


Eligibility criteria:
inclusion criteria: 1. infants born through meconium-stained amniotic fluid, and 2. gestational age at or greater than 35+0 weeks at birth, and 3. postnatal age of 10 to 14 days-old, and 4. full enteral feeds either at semi-demand with a mix of gavage or oral feeds or at full-demand feeds by oral method, and 5. stable respiratory condition for 24-48 hours prior to enrolment, and require respiratory support defined as: receiving non-invasive respiratory support including one of the following 1. high flow nasal cannula of less than or equal to 2l/min/kg and fio2 \<0.25, or 2. low flow nasal cannula at \<100 ml/min exclusion criteria: 1. preterm infants of less than 35+0 weeks gestation, or 2. postnatal age younger than 9 day-old or older than 15 day-old, or 3. parenteral nutrition supplementation or full enteral feeds by gavage, or 4. received caffeine within 5 days prior to enrolment, or 5. currently, receiving invasive respiratory support or continuous positive airway pressure (cpap), or 6. during the study period with the administration of study medication, the infant cannot receive steroids including dexamethasone, hydrocortisone and budesonide by intravenous, enteral or inhalational route, or 7. medical diseases including infections, electrolytes or acid-base imbalances, significant anemia, systematic and metabolic disorders that contribute to respiratory insufficiency other than meconium aspiration syndrome, or 8. congenital anomalies including but not limited to respiratory tract malformations, congenital heart diseases, and syndromal abnormalities.
prevelance, predictors and outcome of sepsis associated liver injury (sali)

Conditions: Liver Injuries

Summary: prevelance, predictors and outcome of sepsis associated liver injury (sali)

patient with liver disease and sepsis at the same time

Eligibility criteria:
inclusion criteria: * clinical diagnosis of sali * must take liver support exclusion criteria: * sali * thyroid disease