Kornimate/medical-research-clean huggingface dataset:
a phase 3 trial comparing tace and tare in unilobar advanced hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: the aim of this study is to compare the efficacy of conventional transarterial chemoembolization(tace) and transarterial radioembolization in patients with unilobar advanced hepatocellular carcinoma.

potentially curative treatments for hepatocellular carcinoma (hcc) include surgical resection, liver transplantation, and local ablative therapy. however, hcc patients are diagnosed at advanced stages in korea. unresectable advanced hccs are not suitable for other curative therapies. for these patients, the optimal treatment remains largely controversial. as a palliative treatment, the benefit of transarterial chemoembolization (tace) had been shown in patients with unresectable hcc by several trials. recently,transarterial radioembolization (tare) has been introduced for the treatment of advanced hcc. however, the efficacy of tare compared to tace is uncertain. the aim of this study is to compare the efficacy of conventional transarterial chemoembolization(tace) and transarterial radioembolization in patients with unilobar advanced hepatocellular carcinoma.

Eligibility criteria:
inclusion criteria: * patients with clinical or histological diagnosis of hcc based on the guidelines of the ajcc * patients with advanced hcc with unilobar advanaced involvement: right lobe ± s4 segment or left lobe ± s4 segment) * patients with single large hcc or multinodular hcc * single \& 5cm \< size \< 15cm * 2-5 nodules \& maximal sized 4-15cm \& sum of diameters ≦ 25cm * infiltrative type \& unilobular involvement on liver mri * segmental or lobar portal vein invasion can be included. * age : 20 years to 80 years * ecog performance status of 0 to 2 * child-pugh class a (child-pugh score 5-6), b (cp score 7) * adequate bone marrow, liver function as assessed by the following laboratory requirements to be conducted within 7 days prior to screening: * wbc count ≧ 1,000/mm3 * absolute neutrophil count \> 500/mm3 * hb ≧ 7.0 g/dl * platelet count \> 100,000 /mm3 * bilirubin ≦ 3 mg/dl * adequate clotting function: inr ≦ 2.3 or ≦ 6sec exclusion criteria: * child-pugh score ≧ 8 * ecog performance status ≧ 3 * patients with chronic kidney disease or serum creatinine ≥ 1.2 mg/dl * history of organ allograft * patients with uncontrolled co-morbidity which needs treatment * patients who have received prior systemic chemotherapy * patients who have received capecitabine within 8 weeks * patients with extrahepatic metastasis * main portal vein invasion * patients with lymph node metastasis * bilobar involvement * bulk disease(tumor volume \>70% of the target liver volume, or tumor nodules too numerous to count) * pregnancy

Keywords: transarterial chemoembolization transarterial radioembolization advanced hepatocellular carcinoma
balance training vs. balance training w/ stars

Conditions: Ankle (Ligaments); Instability (Old Injury)

Summary: chronic ankle instability (cai) is a health condition that results in repeated ankle sprains and other residual impairments. cai has been linked to many different causative factors including sensory and motor deficits that affect the global function of the sensorimotor system as well as the patient. over the past 20 years, strong evidence has been generated to support balance training as an effective intervention strategy in the cai population. unfortunately, most investigations have focused solely on maximizing motor output through balance training, while ignoring the full spectrum of sensorimotor dysfunction associated with cai. there may be advantageous sensory-targeted interventions that augment the effects of balance training and lead to greater enhancements of functional outcomes for cai. however, this possibility has not been systematically explored. sensory-targeted ankle rehabilitation strategies (stars), such as joint mobilization and plantar massage have resulted in improved sensorimotor function in those with cai. however, only a single stars (i.e. stochastic resonance) has been investigated in combination with balance training. while the combined effects were greater than those of balance training alone, stochastic resonance requires relatively expensive equipment that is not commercially available. thus, the purpose of this investigation is to test the hypothesis that combining low cost stars (e.g. plantar massage and joint mobilizations) with balance training will result in greater sensorimotor and functional improvements in those with cai than balance training alone.


Eligibility criteria:
inclusion criteria: * males and females between the ages of 18 and 35. * a history of at least one episode of "giving way" within the past 3 months. * answering 4 or more questions of "yes" on the ankle instability instrument (aii). * score of \<90% on the self-reported foot and ankle ability measure (faam). * score of \<80% on the faam sport. exclusion criteria: * failing to meet the inclusion criteria. * known balance and vision problems. * acute lower extremities and head injuries that occurred \<6 weeks ago. * chronic musculoskeletal conditions known to affect balance. * a history of ankle surgeries to fix internal derangements.

Keywords: chronic ankle instability
joint infection following acl reconstruction

Conditions: Joint Infection

Summary: this study was conducted to analyze the effect of joint infection on the bone tunnel, graft and articular cartilage following arthroscopic single-bundle anterior cruciate ligament (acl) reconstruction with autologous hamstring, to summarize the features of mr findings after joint infection, and to correlate these findings with their possible factors.

a retrospective matched cohort study was performed in 26 patients who underwent arthroscopic single-bundle acl reconstruction with hamstring graft and developed postoperative joint infection in our institute from january 2002 to december 2017. they were matched 1:3 to patients who did not sustain joint infection after acl reconstruction. mr scan was collected at the time of follow-up. bone tunnel enlargement at tunnel aperture, midsection and exit of tibial and femoral tunnel was carefully assessed. graft signal-to-noise quotient (snq) on mri was calculated to evaluate graft maturity. cartilage morphology was graded using whole organ magnetic resonance imaging score. a generalized linear mixed model was applied to analyze the effect of joint infection on the bone tunnel, graft and articular cartilage.

Eligibility criteria:
inclusion criteria: * age between 16 to 50 years; * underwent single-bundle acl reconstruction with autologous hamstring; * had valid follow-up magnetic resonance imaging (mri) at least 1 year after surgery exclusion criteria: * concomitant ligament injury which need surgical repair; * delayed onset of postoperative joint infection (\>3 months after surgery).
traveling-wave transcranial electric stimulation

Conditions: Working Memory

Summary: this study will assess the impact of traveling wave transcranial alternating current stimulation (tacs) on working memory performance in adults.

transcranial alternating current stimulation (tacs) can non-invasively alter neuroelectric activity in the brain by applying weak time-varying electric currents via the scalp. complex patterns of electric brain activity can take the form of traveling waves - spatially coherent brain rhythms that gradually propagate through the neocortex. traveling waves are crucial for the temporal coordination of informational flow in the brain. using the novel traveling-wave transcranial alternating current stimulation (tacs) approach, the investigators will explore the effects of frontal-to-parietal and parietal-to-frontal traveling waves on working memory performance and brain electrophysiology in adults.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 45 years old. 2. confident level of english language. exclusion criteria: 1. history or evidence of chronic neurological or mental disorder. 2. metal or electric implant in the head, neck, or chest area. 3. history of head injuries with loss of consciousness. 4. any acute or chronic medical condition that requires ongoing pharmacological treatment. 5. pregnancy or breast-feeding. 6. alcohol or drug addiction.
safety and efficacy of clobetasol propionate 0.05% e foam in alopecia

Conditions: Alopecia

Summary: the purpose of this study is to ascertain the safety and efficacy of clobetasol propionate 0.05% e foam in the treatment of central centrifugal cicatricial alopecia.

central centrifugal cicatricial alopecia (ccca) is an inflammation-induced hair loss starting in the central scalp and progressing centrifugally. the cause of ccca is unknown. early diagnosis and treatment is essential to stop or slow the progression of scarring and permanent hair loss. once scarring occurs, the hair follicles are obliterated and the hair cannot regrow. thus, anti-inflammatory medications are used to decrease inflammation. current treatment includes topical and intralesional corticosteroids, oral antibiotics, and hair transplantation, all which may take months to years to show improvement. there is no evidence-based medicine on how to treat primary cicatricial alopecias. clobestasol propionate 0.05% emollient foam is an fda-approved and marketed topical corticosteroid for the treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid- responsive dermatoses of the scalp. many studies found the foam to be less irritating than the original formulation.

Eligibility criteria:
inclusion criteria: * patients with ccca, treated or untreated * score 0 - 1 on scale/questionnaire * 18 years of age or older * women of african descent exclusion criteria: * score \> 1 on scale/questionnaire * alopecias other than ccca, including alopecia arreata, lichen planopilaris, trichotillomania, and traction alopecia * history of hair transplantation * children less than 18 years of age * males * women of non-african descent * pregnancy or breastfeeding. women of childbearing age must use reliable forms of contraception (e.g., abstinence, oral contraceptives, or spermicide and condoms) * anti-dandruff shampoo within 30 days * anti-inflammatory medications such as antibiotics (doxycycline, minocycline, rifampin, etc.), steroids (oral prednisone, topical corticosteroids,etc.), nsaids (ibuprofen, aspirin, etc.)

Keywords: alopecia ccca - central centrifugal cicatricial alopecia
the predictive value of heart rate variability for the prognosis of patients with mild to moderate traumatic brain injury

Conditions: TBI

Summary: this study adopts a retrospective design, continuously including patients with tbi treated at the emergency trauma center of the first affiliated hospital of suzhou university from may 2017 to september 2024. investigators used the hospital's electronic medical record system to collect clinical data. the patients' age, gender, history of diabetes, history of hypertension, medication history, mechanism of injury, mean arterial pressure, glasgow coma scale, and other information were recorded upon emergency admission. laboratory indicators included white blood cell count, hemoglobin (hb) levels, platelet count, c-reactive protein, international normalized ratio (inr), and albumin. myocardial injury markers included alpha-hydroxybutyrate dehydrogenase, creatine kinase, lactate dehydrogenase, aspartate aminotransferase, creatine kinase-mb (ck-mb), myoglobin, nt-pro bnp, and high-sensitivity troponin t. additionally, continuous ecg monitoring was conducted for 24 hours after admission.

this study adopts a retrospective design, continuously including patients with tbi treated at the emergency trauma center of the first affiliated hospital of suzhou university from may 2017 to september 2024. investigators used the hospital's electronic medical record system to collect clinical data. the patients' age, gender, history of diabetes, history of hypertension, medication history, mechanism of injury, mean arterial pressure, glasgow coma scale, and other information were recorded upon emergency admission. laboratory indicators included white blood cell count, hemoglobin (hb) levels, platelet count, c-reactive protein, international normalized ratio (inr), and albumin. myocardial injury markers included alpha-hydroxybutyrate dehydrogenase, creatine kinase, lactate dehydrogenase, aspartate aminotransferase, creatine kinase-mb (ck-mb), myoglobin, nt-pro bnp, and high-sensitivity troponin t. additionally, continuous ecg monitoring was conducted for 24 hours after admission.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of traumatic brain injury 2. gcs score between 9-15; 3. head and neck simplified injury score (ais) ≤4; exclusion criteria: 1. clinical diagnosis of tumors, active infections, or hematologic diseases; 2. those who have received treatment with beta-blockers, anticholinergic drugs, or anticoagulants within 6 months before admission;
etanercept treatment in the early course of polymyalgia rheumatica

Conditions: Polymyalgia Rheumatica

Summary: the purpose of this study is to evaluate the effect of the tumor necrosis factor alpha (tnf) antagonist, etanercept, on the early clinical course of polymyalgia rheumatica (pmr). pmr is a common inflammatory disease with an unknown etiology that is characterized by aching, tender, and stiff proximal muscle. some evidence suggests that tnf plays a central role in the pathophysiology of pmr. the preferred treatment with glucocorticoids (gcs) is adequate for most patients, but a subset of patients have a more prolonged, relapsing disease course. these patients require treatment with gcs for 1 to 2 years. gc related adverse events are frequent during treatment.


Eligibility criteria:
inclusion criteria: * persons with active polymyalgia rheumatica (patients only). * signed informed consent and written authorization. exclusion criteria: * other inflammatory conditions than polymyalgia rheumatica, including symptoms of giant cell arteritis, e.g. head aches, jaw claudication and visual disturbances. * current malignancy or history of malignancy. * neuromuscular conditions. * infections with systemic impact. * uncontrolled diabetes mellitus. * uncontrolled hypertension. * current tuberculosis or history of tuberculosis. * severe heart failure (nyha class 3 and 4). * current use of glucocorticoids, biological drugs, and immunosuppressive drugs. exclusion criteria (controls): * polymyalgia rheumatica.
comparison of isometric and isokinetic strength training effects on physical performance in athletes with knee pain

Conditions: Knee Injuries

Summary: frequent sports events causing more injuries in athletes causing decline in their performance. injuries around knee joint are common. strength training of hamstring and quadriceps are effective tool in rehabilitation. the multi-speeds and multi-angles strength training plans were used to see the effects on symptoms and performance in athletes.

a total of 69 athletes with knee pain were recruited and randomly divided into two groups. 50 athletes completed the training programs, 25 in each group. data was also collected from healthy athletes for normative values. international knee documentation committee subjective knee evaluation form was used to report the athlete's knee condition and severity of symptoms including pain. biodex isokinetic system was used for isokinetic and isometric strength trainings and kinetic data collection. physical performance of an athlete was assessed by components of fitness through two commonly used tests: illinois agility run test and vertical jump test. the athletic single leg stability test was used to assess the stability of athletes on biodex balance system.

Eligibility criteria:
inclusion criteria: * the adult athletes between ages 18 to 35 years. * athletes with unilateral knee pain. * both male and female. exclusion criteria: * athletes with bilateral knee pain and any deformity around knee were excluded from this study. * any other joint involvement of lower limb while assessment were also excluded from study. * athletes with recent history of surgeries for fractures or ligamentous reconstruction were excluded from this study. * patients who were medically unstable.

Keywords: isokinetic, isometric, agility athletic single leg stability, vertical jump biodex, knee pain
feasibility of action observation training [aot] in infants after unilateral brain lesion

Conditions: Perinatal Brain Injury

Summary: the study examines whether infants with a perinatal unilateral brain lesion can perform an "action observation training" \[aot\] at the age of 9-12 months . aot is the targeted and concentrated observation of movements and actions to learn new motor skills. in adults with hemiplegia after a stroke and in older children with hemiplegia, aot can lead to an improvement in the functions of the affected hand/arm. infants with early unilateral brain damage are at increased risk of developing a hemiplegia and thus impaired upper limb function. there is little known about treatment options to promote arm and hand skills in early childhood and their effectiveness. in particular, there is a lack of knowledge whether aot could also be used in infants. it is known that even in infants at an early age brain activity can be measured while they are observing movements and infants learn a lot about observing and imitating. knowledge about the measurement of manual skills is also reduced. so far, tests have been used to observe and evaluate how infants use their hands when playing (e.g. mini-assisting hand assessment). the aim of this study is to investigate whether measurements with motion sensors can also be used in infants. in the pre-post study, about 5 to 10 toddlers will be examined. during four weeks, the parents should give the child 20 minutes of aot per day at home. a therapy diary will be completed for this purpose. during six weeks, the parents will use movement sensors on two days a week for the upper limb of the infants. finally, three questionnaires about the aot and the motion sensors will be completed by the parents.


Eligibility criteria:
inclusion criteria: * premature and term-born infants aged 9-12 months * perinatal unilateral brain damage due to cerebral hemorrhage or stroke * informed consent to study participation by the parents or legal representative exclusion criteria: * infants with impaired vision * other diagnoses than early childhood brain damage affecting the functions of the upper extremities (e.g. plexus palsy) * infants who participate in other studies of upper extremity interventions * parents do not understand the study and the intervention due to foreign language skills
home-based transcranial direct current stimulation (tdcs) for behavioral symptoms in alzheimer's disease and related dementias (adrd)

Conditions: Alzheimer Disease

Summary: the purpose of this study is to assess acceptability, and safety of providing tdcs to adrd patients with behavioral symptoms and to assess the efficacy of tdcs for adrd-related symptoms, mainly behavioral symptoms.


Eligibility criteria:
inclusion criteria: * have adrd and clinically-meaningful behavioral symptoms * have a caregiver willing to participate in the study * can speak and read english * have stable doses of medications for at least one month exclusion criteria: * any unstable concurrent medical conditions * history of brain surgery * seizure * intracranial metal implantation * current alcohol/substance use disorder

Keywords: depression anxiety irritability apathy psychosis tdcs
carotid b-mode ultrasound study to compare anti-atherosclerotic effect of torcetrpib/atorvastatin to atorvastatin alone.

Conditions: Hypercholesterolemia, Familial; Hyperlipidemia

Summary: the torcetrapib project was terminated on december 2, 2006 due to safety findings. to look at ultrasound images taken in the carotid arteries and to look at various lipids in the blood of people with heterozygous familial hypercholesterolemia

for additional information please call: 1-800-718-1021

Eligibility criteria:
inclusion criteria: * diagnosis of heterozygous familial hypercholesterolemia * at least 18 years of age exclusion criteria: * women who are pregnant or lactating, or planning to become pregnant. * subjects with a clinically indicated need for statin (hmg-coa reductase inhibitor) therapy other than atorvastatin or other concomitant therapy with known lipid altering effects on ldl-c and hdl-c including fibrates and nicotinic acid (high doses) * subjects taking any drugs known to be associated with an increased risk of myositis in combination with hmg-coa reductase inhibitors * subjects with any other medical condition or laboratory abnormality which could affect subject safety, preclude evaluationof response, or render unlikely that the subject would complete the study
why subfertile couples drop out

Conditions: Subfertility

Summary: dropout rates for fertility treatments are high. this study will examine the rate of patients that drop out during any type of subfertility work up or treatment. furthermore, we will determine what reasons for discontinuation are and we will identify the demographic characteristics of the couples and the prognostic factors for drop out during assessment or treatment at a fertility centre in the isala (zwolle), erasmus university centre (rotterdam), elisabeth twee steden hospital (tilburg), reinier de graaf group (voorburg), st antonius hospital (nieuwegein), maxima medical centre (veldhoven) and noordwest hospital group (den helder/alkmaar) in the netherlands.

rationale although fertility success rates are rising due to improved techniques and patients are usually highly motivated at their first visit of the clinic, dropout rates are high. research has shown that fertility treatment is a cause for physical, psychological and economic burden. objective the aim of this study is to examine the rate of patient drop out during any type of subfertility work up or treatment. furthermore, the investigators want to determine what the reasons for discontinuation are and to identify the demographic characteristics of these couples and the prognostic factors for drop out during assessment or treatment at a fertility clinic. study design prospective cohort study at the fertility centres of isala (zwolle - the netherlands), erasmus university centre (rotterdam- the netherlands), elisabeth twee steden hospital (tilburg - the netherlands), reinier de graaf group (voorburg - the netherlands), st antonius hospital (nieuwegein - the netherlands), maxima medical centre (veldhoven - the netherlands) and noordwest hospital group (den helder/alkmaar - the netherlands). study population every couple that undergoes any type of work up or treatment for subfertility problems and that has not visited any other clinic yet. methods patient records of included couples will be studied and included patients will be asked to fill in a validated questionnaire after evaluations during work up or treatment. the data from both will be put in a database and analysed. first visit (q1) epq-rss, screenivf, mmq, fertiqol, demographic questions (128 items) evaluation (q2) fertiqol, hads (48 items) evaluation (q3) \>4-6 cycles non-ivf (q3) fertiqol, hads (48 items) evaluation (q4) \> 3 cycles ivf (q4) fertiqol, hads (48 items) dropout (q5) fertiqol, screenivf, mmq, pcq-infertility, reasons for dropout (128 items) pregnancy (q6) pcq-infertility (53 items)

Eligibility criteria:
inclusion criteria: * couples with any type of subfertility referred to one of the four participating centres * both partners are willing and able to separately fill out the questionnaires. exclusion criteria: * unable to read or speak the dutch language * medical contra-indication for pregnancy * previous ofo (initial infertility consultation), non ivf or ivf/icsi cycles

Keywords: reasons for dropout subfertility ivf non ivf