Kornimate/medical-research-clean huggingface dataset:
sars-cov2 (covid-19) diagnosis in human saliva by maldi-tof ms profiling

Conditions: SARS-CoV 2

Summary: since march 2020, sars-cov2 virus (ncov19; covid-19) is considered pandemic. its high rate of spread and infection in the human population and the lack of effective and validated treatment have led the authorities of several countries to confine their populations to slow the spread of covid-19. as part of the management of this health crisis, the screening of individuals is essential in order to isolate "infected cases". these screening tests are currently performed on nasopharyngeal swabs using rt-pcr for the detection of viral rna. although sensitive and specific, these tests remain relatively long (2-5 hours), expensive and the strong international demand for nucleic extraction kits and enzymes are factors limiting the implementation of widespread screening (problem of supply of swabs, molecular biology consumables). in order to prevent the risks of a shortage of screening means, we propose to develop an innovative alternative strategy, pcr-free, based on the detection of specific protein signatures in human saliva by maldi-tof ms profiling. maldi-tof ms profiling is a method used in routine diagnostics by microbiology laboratories for the identification of microorganisms. maldi-tof ms profiling has been successfully used to classify individuals according to their infectious status (oral pathologies) based on the analysis of their saliva, but also as a tool for the identification of respiratory viruses from cell culture supernatants. in addition, we have expertise and skills in the field of maldi-tof ms profiling and have implemented new strategies to improve the quality of profiles and their analysis, particularly in the context of entomological and vector identification projects. finally, recent chinese studies have reported that covid-19 was detectable in saliva by rt-pcr. the main objective of this study is to develop a test based on the maldi-tof profiling method to detect individuals infected with sars-cov2 from saliva sample.


Eligibility criteria:
inclusion criteria: * 18 years of age; * screened for sars-cov2 by rt-pcr from a nasopharyngeal swab within 96 hours prior to inclusion. exclusion criteria: * patient admitted to intensive care; * pregnant woman.

Keywords: maldi-tof ms
can postoperative outcomes be predicted from asking osa screening questions pre-operatively?

Conditions: Obstructive Sleep Apnea

Summary: the proposed research will determine whether a 6-item screening questionnaire previously shown to correlate with moderate or severe osa is useful for predicting postoperative outcomes in children undergoing surgery under general anesthesia.

the survey will be administered preoperatively in the ent clinic or the preoperative surgical unit. the following data will also be recorded: patient demographics (age, gender, bmi), surgical procedure, length of procedure and anesthetic, and smoking exposure. based on differences in postoperative outcomes (e.g., supplemental oxygen requirement in the pacu) observed in the derivation cohort for the 6-item questionnaire, the study will enroll 1,000 patients to attain sufficient power for evaluating the 6-item questionnaire in the overall cohort and in demographically or clinically defined subgroups.

Eligibility criteria:
inclusion criteria: * the study will include all who are presenting for surgery to the main operating room, ambulatory surgical center or procedure center at nationwide children's hospital. exclusion criteria: * emergency surgery and any caregiver or patient refusal.
lipoprotein lipase expression in chronic lymphocytic leukemia

Conditions: Chronic Lymphocytic Leukemia

Summary: the investigators hypothesize that lipoprotein lipase (lpl) expression on chronic lymphocytic leukemia (cll) cells will predict a more aggressive clinical course. the results from this proposal will validate the use of a novel antibody developed at dartmouth-hitchcock in cll and will predict cll patients that have a more aggressive form of the disease. the investigators work will also provide direct evidence that lpl is expressed on cll cells and provides a critical source of fatty acids required by the cll cells to grow and survive. fatty acid metabolism may become a therapeutic target in cll in the future.

the investigators plan to use a novel antibody developed at dartmouth-hitchcock medical center to characterize the expression of lpl in cll. peripheral blood from cll patients will be analyzed by flow cytometry to detect the expression of lpl and to investigate if lpl expression correlates with a more aggressive type of cll. the investigators propose that lpl protein expression on cll cells is prognostic and that lpl and other proteins involved in fatty acid metabolism are critical for cll cells to survive.

Eligibility criteria:
inclusion criteria: * diagnosis of cll as per national cancer institute working group guidelines * patients undergoing routine blood draws as part of their ongoing follow up for cll * 18 years or older * ability to provide consent in english * patient must have measurable disease as defined by an absolute lymphocyte count greater than 5,000/mm3 or have archived lymph node or bone marrow with cll involvement. exclusion criteria: * patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for their cll, * other hematologic malignancy or other disease process within the past 6 months are excluded.

Keywords: lipoprotein lipase chronic lymphocytic leukemia cll
mental health associations with vitiligo

Conditions: Vitiligo; Depressive Episode; Recurrent Depressive Disorder; Anxiety Disorders; Social Phobia; Adjustment Disorders; Substance Abuse; Self-Harm, Deliberate; Overdose; Suicide, Attempted; Parasuicide

Summary: this cohort study is a large population-based study in the uk to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with vitiligo compared to controls and to evaluate whether the relative risks may vary by different ethnicity.

this study has two primary outcomes 1) prevalence and incidence of mental health condtions in people diagnosed with vitiligo compared to matched controls and 2) primary care and secondary healthcare utilisation in patients diagnosed with vitiligo and having a prevalent depressive conditon compared to matched controls. in addition, the study examines risk of time off work and unemployment in people diagnosed with vitiligo compared to matched controls.

Eligibility criteria:
inclusion criteria: * all eligible adults ≥18 (as at date of vitiligo diagnosis for cases or start of follow-up for controls) registered with gp practices contributing data to opcrd between january 1, 2004 and december 31, 2020, were eligible for inclusion in the study. exclusion criteria: * people with less than 1 year of follow up available
photoplethysmographic scaling of dyspnoea

Conditions: Respiratory Failure

Summary: timely prediction of impending respiratory failure is vital, yet relies on subjective clinical assessment of the patient's respiratory status. pulse oximetry plethysmographic signal analysis is indicative of the effort to breathe and may provide an objective measurement of respiratory loading.

initiating invasive mechanical ventilation is a vital and delay-critical decision. precise and timely prediction of impending respiratory failure would be highly consequential. subjective evaluation of respiratory loading conditions is inconsistent, imprecise and may result in erroneous management. photoplethysmographic (pop) waveform analysis provides a non-invasive, readily available tool to estimate breathing effort in a semiquantitative fashion. it is the aim of this study to examine: 1. if the degree of dyspnoea, when clinically assessed by means of the respiratory rate and spo2 values, correlates with the spo2 wave variations (δpop) in icu spontaneously breathing covid-19 and non-covid-19 patients. 2. if a δpop threshold could be identified to adequately predict further need of orotracheal intubation and invasive mechanical ventilation. this study consists of three main steps: 1. clinical evaluation of dyspnoea based on: 1.1. respiratory rate 1.2. oxygen saturation (spo2) 2. storage of spo2 curve for δpop computation according to a proprietary algorithm after offline pop analysis . 3. within a time frame of 10 days from when the first two steps are met, monitor for need of invasive ventilatory support.

Eligibility criteria:
inclusion criteria: * informed consent from patient or next-of-kin according to local administrative decision * spontaneous breathing, including during prone position * sinus rhythm * minimum standards for icu monitoring: ecg, blood pressure (invasive or non-invasive), respiratory rate (by ecg signal), spo2 and temperature exclusion criteria: * suspected pregnancy * weight \> 120 kg or \< 60 kg * emergency or urgency * intubated ( and mechanically ventilated) patient * non- sinus rhythm * left ventricular ejection fraction (lvef) ≤ 30% * right ventricular (rv) dysfunction ( rvef ≤ 30% at transthoracic echocardiography (tte)) * significant pulmonary hypertension (pht) (tte: mean pulmonary arterial pressure (mpap) ≥ 35 mm.hg)

Keywords: breathing effort plethysmography pulse oximetry dyspnoea mechanical ventilation
nutritional restriction and activity thermogenesis

Conditions: Obesity

Summary: these studies will provide us with enormous insight regarding how obese patients adapt energetically during negative energy balance. we will gain fundamental information regarding the metabolic implications of combining food restriction with a walking program compatible to that advocated by statutory agencies. these studies will lead to improved understanding of the energetic adaptation that occurs during negative energy balance and how best to treat patients with obesity.


Eligibility criteria:
ninety sedentary subjects, aged 25-55, who live \<10 miles from rochester will be recruited. this age range has been selected to enable us to study individuals at the peak age-range of obesity and over-weight prevalence and to avoid issues of menopause. subjects will not be eligible for consideration if they take two or more bouts of exercise/week or participate in sports for more than 2 hours/week. subjects with predicted weight maintenance energy requirements of \<2000 kcal/day will have been excluded at screening. this is because when we come to underfeeding by 1000 kcal/day, we want to avoid feeding any volunteer \<1000 kcal/day, for safety \& compliance reasons. (a) lean: 30 (15f,15m) lean subjects; bmi \ 30 kg/m2 and a weight loss sufficient to achieve a bmi of \<26 kg/m2 maintained for at least 2 months (with weight fluctuation during this period of \<1 kg) (94). we will attempt to match these subjects to the obese subjects as described above.

Keywords: physical activity
scleroderma treatment with celution processed adipose derived regenerative cells (star)

Conditions: Scleroderma; Systemic Sclerosis; Raynaud Phenomena; Raynaud's Disease

Summary: the primary objective of this study is to assess the safety and efficacy of the celution device in the processing of an autologous graft consisting of adipose derived regenerative cells (adrcs) in the treatment of hand dysfunction due to scleroderma.

the star trial is a prospective, randomized, multi-center device trial intended to assess safety and efficacy of subcutaneous administration of celution processed adrcs into fingers of patients with hand dysfunction due to scleroderma. following informed consent and screening evaluations, eligible subjects will undergo pre-operative testing. subjects will then undergo fat harvest through small volume liposuction under local anesthesia. lipoaspirate will be processed in the celution system to isolate and concentrate adrcs for immediate subcutaneous administration under local anesthesia. subjects will be randomly assigned to receive adrcs (40 million cells) or a visually-matched placebo in a 1:1 ratio. all subjects will receive subcutaneous administration of test substance (adrc or placebo) into all fingers of both hands. following completion of all 48 week visits and database lock, placebo treated subjects will be offered treatment with their adrcs cells should they continue to qualify according to the inclusion/exclusion criteria and should they wish to be treated with adrcs and agree to the fat harvest procedure.

Eligibility criteria:
key inclusion criteria: 1. males or females ≥ 18 and ≤ 70 years of age 2. diagnosis of diffuse cutaneous scleroderma (duration \> 5 years) or limited cutaneous scleroderma. 3. cochin score ≥ 20 units 4. ability to safely undergo liposuction 5. symptoms consistent with raynaud's phemomena 6. compliant with standard preventative recommendations key exclusion criteria: 1. body mass index \< 18 kg/m2 2. active infection in any finger during screening period or infection in any finger requiring antibiotics in the 30 days prior to the screening visit 3. active infection at the potential site(s) of fat harvest during the screening period 4. contractures of any finger or ulceration at point of injection precluding completion of injection procedure 5. amputation of any finger proximal to the proximal interphalangeal joint or any amputation in more than one finger 6. diagnosis of rheumatoid arthritis 7. inflammatory arthritis of the hand, including significant osteoarthritis, that is not due to scleroderma or significant acute inflammation in the hand that is due to scleroderma, as per the investigator's clinical judgment 8. oral cyclophosphamide exceeding 2 mg/kg/day, any intravenous cyclophosphamide, methotrexate exceeding 25 mg/week, mycophenolate mofetil exceeding 3 gm/day, hydoxychloroquine exceeding 7 mg/kg/day or azathioprine exceeding 300 mg/day or any other immunosuppressive medication in the 90 days prior to the screening visit
exercise dosing for pain in healthy participants

Conditions: Pain

Summary: in this study investigators will examine the effect of dose related to exercise therapy for pain in healthy adult humans. an acute pain model will be employed to study the effect of exercise dose on pain. acute pain models are currently used to study pain (both acute and chronic) in human samples as there is currently no chronic pain model.

this study is designed as a randomized controlled trial with repeated measures. the effect of exercise dose on pain: subjects will be randomly assigned to one of four exercise groups: 1.) no exercise (control); 2.) low dose exercise (3x/week); 3.) moderate dose exercise (5x/week). 4.) high dose exercise (10x/week).

Eligibility criteria:
inclusion criteria: 1. between age 18-40 2. normal bmi (18.5-25.0) 3. heart rate (hr) 60-100 bmp 4. bp less than or equal to 140/90 exclusion criteria: 1. age \ 40 years 2. cardiac, respiratory, neurological or musculoskeletal disease 3. acute pain 4. chronic pain condition 5. diabetes 6. bmi ≥ 25.1 or ≤ 18.4 7. regular participation in high intensity athletic/sporting activities 8. sedentary 9. anxiety or depression disorders 10. tape allergy 11. currently pregnant

Keywords: exercise dose analgesia
menier's disease - bone density study

Conditions: Meniere Disease; Osteoporosis; Osteopenia; Vitamin D Deficiency; Vestibular Disorder

Summary: meniere's disease is a progressive and debilitating inner ear disease characterised by vertigo and hearing loss. several studies have linked menierws disease with lower bone density and lower vitamin d levels. in the current prospective study definite meniere's patients will be followed over a period of 2 year, during which repetitive measurements of bone density, vitamin d plasma levels, blood pressure as well as hearing and vestibular tests will be made. results will be compared to healthy controls.


Eligibility criteria:
inclusion criteria: * definite meniere's disease exclusion criteria: * hyperthyroidism * hyperparathyroidism * acromegaly * hypogonadism * diabetes melitus * chronic renal failure * alcoholism * cushing syndrome * rheumatoid arthritis * systemic lupus erythematosus * ankylosing spondylitis * inflammatory bowel disease * obstructive lung disease * sarcoidosis * amyloidosis * celiac disease. * chronic treatment with bisphosphonates * chronic treatment with glucocorticoids * chronic treatment with androgen deprivation therapy * chronic treatment with gonadotropin releasing hormone agonist chronic treatment with aromatase inhibitor chronic treatment with loop diuretics chronic treatment with proton pump inhibitors chronic treatment with anti-seizure drugs chronic treatment with warfarin chronic treatment with ssri chronic treatment with alpha or beta-blockers
short- and longterm effects of physical activity and dietary restriction postpartum

Conditions: Obesity

Summary: the study will investigate whether physical exercise, or dietary restrictions, or a combination of both, among overweight and obese postpartum women lead to a significantly larger reduction in weight in a longer perspective, compared to similar women not receiving the intervention. the study also will investigate the effects on body composition, cardiovascular fitness, blood lipids, insulin levels and inflammation markers. in total, 68 women with pre-pregnancy bmi 25 - 34.9 will be randomized at 10 wk postpartum into: (1) physical exercise, (2) dietary restrictions, (3) physical exercise + dietary restrictions and (4) control group. the intervention lasts for 12 wk and longterm effects are measured 1 yr after trial initiation. to date only studies showing short term (12 wk) effects exist. our study is the first to include four intervention groups, so that separate effects of physical activity and dietary restriction and their interaction, can be assessed. further, the investigators will estimate effects on body composition taking body water into account and estimate total energy expenditure with higher precision than previously. overweight and obesity is an escalating problem in sweden. sustainable weight reduction programs are urgently needed. during the postpartum period, women may be motivated to lose weight. information aimed at promoting life style changes among overweight and obese women could in a longer perspective be integrated in the regular maternal health care in sweden.


Eligibility criteria:
inclusion criteria: * prepregnant bmi 25-35 * non smoking, single term birth * intention to breastfeed exclusively for 6 mo exclusion criteria: * diseases or medication in mother or child

Keywords: obesity diet exercise
effects of mode of contraction on neuromuscular fatigue

Conditions: Volunteers

Summary: aging is associated with multiple deteriorations of the neuromuscular system. given the increase in life expectancy, the investigators can now distinguish old adults (\>60 years old) who conserve their neuromuscular capacities with regular physical activity and very old adults (\>80 years old) who suffer from an inexorable decline, even if the number of octogenarians and their quality of life are progressively increasing. however, the most part of the literature on fatigue and neuromuscular capacity with aging focused on isometric tasks. the results showed a significant decrease in maximal force production capacity and a greater resistance to fatigue for old people compared to the young population. when fatigue is induced trough dynamic contractions, greater fatigability was observed in old adults compared to young adults. investigations performed on the population aged over 80 years old are rare, showing greater fatigability in octogenarians than old men (aged 60-80 years old) during isometric tasks. the knowledge about the effects of dynamic contractions in this population are limited, and performed uniquely in single leg isokinetic mode. evaluations that require the use of both legs and higher muscle mass involved in the task (cycloergometer) are needed. understanding neuromuscular fatigue and fatigability across different exercise modalities is necessary to set adapted physical activity programs aimed to maintain autonomy in older individuals.


Eligibility criteria:
inclusion criteria: * belong to a defined age group: young (18 to 35 years old inclusive), old (60 to 80 years old inclusive) and very old (81 to 95 years old inclusive), * signed written consent form * being affiliated to social security exclusion criteria: * pathology or surgery resulting in a locomotor disorder, within 6 months prior to the study, * chronic neurological, motor or psychological pathologies * use of neuro-active substances likely to alter cortico-spinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) for the duration of the study. * contraindication to magnetic stimulation: * cardiac or respiratory insufficiency. * cardiac pacemaker. * cardiac valve wear and serious cardiovascular diseases. * presence of prosthetic material or ferromagnetic foreign bodies in the head. * presence of cochlear implants or ocular prosthetic material. * history of neurosurgical interventions. * neurological diseases that may affect brain structures and cognitive abilities (e.g., intracranial tumour, multiple sclerosis, history of stroke or traumatic brain injury). * history of comitiality, contralateral knee pathology or pathology of the musculoskeletal system. * mini mental state examination \< 20

Keywords: aging neuromuscular performance central fatigue peripheral fatigue dynamic
a research study looking at how a single dose of the study medicine nnc0194-0499 behaves in participants with reduced liver function compared to participants with normal liver function

Conditions: Hepatic Impairment; Healthy Volunteers

Summary: the study medicine nnc0194-0499 is under development for non-alcoholic fatty liver disease (nafld) including non-alcoholic steatohepatitis (nash). all participants will receive a single dose of 30 milligram (mg) of the study medicine. the study medicine will be given in the form of an injection of 0.6 millilitres in a skinfold of the thigh (subcutaneous). the study will last for up to 64 days. women cannot take part if pregnant, breast-feeding or plan to get pregnant during the study period. women who are able to become pregnant must use highly effective contraception and will be counselled on the use of contraception. participants with impaired liver function will undergo an ultrasound of the belly and measurement of brain activity.


Eligibility criteria:
inclusion criteria: * male or female. * aged 18-80 years (both inclusive) at the time of signing informed consent. * body mass index (bmi) between 18.5-39.9 kilogram per square meter (kg/m\^2) (both inclusive). specific inclusion criterion only for participants with hepatic impairment: * participants with stable hepatic impairment classified as child-pugh grade a, b or c as assessed by the investigator. stable hepatic impairment is defined as no clinically significant change in disease status, as judged by the investigator. exclusion criteria: * known or suspected hypersensitivity to study intervention(s) or related products. * female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using a highly effective contraceptive method.
naturally banded sleeve gastrectomy

Conditions: Obesity, Morbid

Summary: the idea is to use an omental flap or round ligament as a natural band in stead of synesthetic band in bariatric procedures, mainly gastric sleeve

the idea is to use an omental flap or round ligament as a natural band in stead of synesthetic band in bariatric procedures, mainly gastric sleeve

Eligibility criteria:
inclusion criteria: * obese patients with bmi more than 40 with or without co-morbidity or more than 35 with co-morbidity * patients fit for laparoscopic surgery * give approval to share in the study * previous restrictive bariatric procedure exclusion criteria: * patients unfit for surgery * patients aged less than 18 and older than 60 * patient with previous upper abdominal surgery either for obesity or other diseases