Kornimate/medical-research-clean huggingface dataset:
survey of patients taking iop-lowering eye drops

Conditions: Glaucoma; Ocular Hypertension

Summary: survey to assess perspectives of patients prescribed iop-lowering eye drops at a single office visit.


Eligibility criteria:
inclusion criteria: * prescribed iop-lowering eye drops exclusion criteria: * can complete survey instrument in english
investigating the effects of mindfulness-based self-compassion training given to parents of children with cerebral palsy on parents' self-efficacy, caregiver burden, and emotion regulation

Conditions: It is Planned to Provide Self-compassion Training to Parents of Children With Cerebral Palsy

Summary: the purpose of this observational study is to learn the effects of mindfulness-based self-compassion training given to parents of children with cerebral palsy. the main question it aims to answer is: -is mindfulness-based self-compassion training effective on parents' caregiver burden, self-efficacy, and emotion regulation? parents who receive self-compassion training will answer survey questions before and after the training.


Eligibility criteria:
inclusion criteria(for parents): * having a child diagnosed with cerebral palsy between the ages of 1-18, * being literate, * not having communication problems, * being between the ages of 18-65. inclusion criteria(for childs): * having been diagnosed with cerebral palsy, * being registered in a special education and rehabilitation center. exclusion criteria: * caring for other dependents (elderly, disabled, etc.), * having a mental illness (major depression, psychosis, etc.), * having communication problems, * not continuing education.

Keywords: mındfulness self compassion education cerebral palsy parent care burden emotional regulation
on-pump vs. off-pump cabg in high-risk patients (euroscore 6+)

Conditions: Ischemic Heart Disease; Post-Operative Complications

Summary: previous studies comparing on-pump and off-pump operating strategy did only partially demonstrate benefits of the off-pump myocardial revascularisation.in primary end-points (mi, death, renal failure, and so on) there was no significant difference, but in secondary end-points we observed benefits resulting for patients. we would like to show the benefit of the method without extracorporeal circulation in patients with higher and hight operation risk, coming from euroscore classification system (6 points and more).


Eligibility criteria:
inclusion criteria: * stable form of ischemic heart disease * unstable angina pectoris * acute myocardial infarction * additive euroscore 6 and more * informed approval of the patient exclusion criteria: * significant heart valve disease, requesting surgery * aortic aneurysm requesting surgery

Keywords: off-pump opcab euroscore high-risk patients quality of life validity of euroscore
follow-up study after 11 years of patients who were included in the benefit trial (304747) with a first demyelinating event suggestive of multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this study assesses clinical and imaging long-term data, after early or delayed interferon-beta-1b treatment in patients with a first demyelinating event suggestive of multiple sclerosis (ms), 11 years after enrollment in the betaferon/betaseron in newly emerging multiple sclerosis for initial treatment (benefit) study (304747). the main objectives are to describe the disease course, change in disability, cognitive function, resource use and employment status, in relation to interferon beta-1b in the long term.

as optic coherence tomography (oct) and magnetic resonance imaging (mri) studies are essential to standardize the procedures and assessments for all oct and mri test centers that may take part in this study, 122 additional volunteers will be enrolled to test the dummy scans of oct and mri, only.

Eligibility criteria:
inclusion criteria: * male and female patients with clinical-isolated syndrome or multiple sclerosis who have been treated at least once in benefit study 304747 exclusion criteria: * patients who, according to the investigator's judgment, have medical, psychiatric, or other conditions that compromise the patient's ability to understand the purpose of the study
a prospective cohort study of aged people for chronic diseases

Conditions: Aging; Sarcopenia

Summary: this study is a hospital-based, prospective cohort study to elucidate the predictive factors including muscle and fat mass for chronic diseases and mortality in elderly persons aged 60 years and older.

this study is a hospital-based, prospective cohort study to elucidate the predictive factors among anthropometric and biochemical parameters and body composition information for chronic diseases including diabetes mellitus, myocardial infarction, stroke, osteoporosis, fracture, and cognitive dysfunction, and mortality in elderly persons aged 60 years and older.

Eligibility criteria:
inclusion criteria: * aged 60 years and older * capable of communication with the research team * provided written informed consent exclusion criteria: * age \< 60 years * active malignancy * uncompensated liver cirrhosis * esrd * severe cognitive impairment which cannot communicate with the research term

Keywords: sarcopenia sarcopenic obesity osteoporosis fracture cardiovascular disease mortality
dynesys spinal system post market 522 study

Conditions: Degenerative Spondylolisthesis; Pseudoarthrosis

Summary: the purpose of this study is to assess the safety and fusion rates following posterior lateral fusion with the dynesys spinal system used as an adjunct to fusion and compare to literature control.

study is meant to assess the safety and fusion rates following posterior lateral fusion with the dynesys spinal system.

Eligibility criteria:
inclusion criteria: 1. skeletally mature between the ages of 20-80 2. candidate for posterior lateral fusion between t1-s1 with autograft 3. degenerative spondylolisthesis with evidence of neurologic impairment or failed previous fusion (pseudoarthrosis) 4. symptoms of leg and/or back pain 5. non-responsive to conservative/non-surgical treatment for at least three (3) months 6. must be willing and able to comply with study requirements; including complete necessary study paperwork and return for required follow-up visits exclusion criteria: 1. active systemic or local infection 2. obesity 3. use of interbody device 4. pregnancy 5. mental illness 6. incarceration 7. alcohol or drug abuse 8. severe osteoporosis or osteopenia 9. use in the cervical spine 10. sensitivities/allergy to metals, polymers, polyethylene, polycarbonate urethane and polyethylene terephthalate 11. soft tissue deficit not allowing sound closure 12. any medical or physical condition that would preclude the potential benefit of spinal implant surgery 13. congenital abnormalities, tumors or other conditions that would prevent secure component fixation that has the potential to decrease the useful life of the device 14. active malignancy or other significant medical comorbidities 15. any medical or mental condition which would put the patient at high risk due to the severity of surgery 16. inadequate pedicles of the thoracic, lumbar and sacral vertebrae 17. patient unwilling or unable to follow postoperative instructions

Keywords: dynesys dynamic stabilization system spondylolithesis pseudoarthrosis neurologic impairment failed fusion
analysis of the quality and quantity of antibiotic prescriptions for bacterial respiratory tract superinfection in patients hospitalized in covid-19 wards

Conditions: SARS-CoV Infection; Antimicrobial Stewardship; Respiratory Tract Infections; Antibiotic Resistance

Summary: in this prospective observational study, a quantitative and qualitative analysis of antibiotic prescriptions for presumed respiratory tract (super)infection in patients hospitalized on covid-19 wards will be made. drivers of antibiotic prescription for presumed respiratory tract infection in patients suspected of being infected with covid-19 or with definite covid-19 infections will be identified.

patients hospitalized on a covid-19 ward for more than 24 hours will be included. those with one or more antimicrobial prescription(s) for a presumed respiratory tract (super)infection will be identified and every antibiotic dose will be scored as appropriate, inappropriate, suboptimal or unnecessary by at least two infectious disease (id) specialists, on an independent manner. if the scoring of the two id specialists will defer, a third id specialist will come to a conclusion after discussion with the two other id specialists. a quantification of the total amount of antibiotics, prescribed for presumed respiratory tract (super)infection will be made for patients with a covid-19 diagnosis, but also a quantification for every category of appropriateness will be made. possible drivers like the degree of hypoxemia, laboratory parameters, qsofa score, duration of symptoms, age, comorbidities, symptoms,... associated with the prescription of antimicrobials for a presumed respiratory tract (sur)infection will be identified.

Eligibility criteria:
inclusion criteria: * men and women hospitalized in one of the covid wards (no data will be collected during a stay on the icu department) of uz brussel for more than 24 hours and willing to sign the informed consent form (or signed by one of their legal representative(s) if unable). exclusion criteria: * patients younger than 18 years old * patients not willing to sign the informed consent form * patients hospitalized for a shorter duration than 24 hours on a covid-19 ward

Keywords: respiratory tract infection antimicrobial stewardship sars-cov infection covid-19 antibiotic resistance
immersive virtual reality for neuropathic pain

Conditions: Neuropathy; Phantom Limb Pain; Complex Regional Pain Syndromes; Neuropathic Pain

Summary: investigating how neuropathic limb pain, including phantom limb pain or complex regional pain syndrome, is affected by virtual reality. while several studies have looked into virtual reality for treating this type of pain, few have used the latest immersive virtual reality hardware combined with motion control for an engaging virtual mirror therapy experience. the investigators are interested in studying the use of virtual reality as an alternative treatment option for these conditions.


Eligibility criteria:
inclusion criteria: * diagnosis of complex regional pain syndrome or phantom limb pain in an upper or lower limb exclusion criteria: * cognitive impairment leading to inability to make own medical decisions * complete inability to utilize leg or arm muscles that are needed for motion controller tracking * history of seizures within the last year
addressing stress among women entrepreneurs in ethiopia - scale up

Conditions: Mental Stress; Stress; Stress, Job; Emotion Regulation; Violence, Gender-Based; Economic Problems

Summary: the objective of this study is to examine the impact of the "doing what matters in times of stress" guided self-help handbook, along with phone-based lay helpers sessions, on the psychological well-being, business performance, and incidence of intimate partner violence among women entrepreneurs in ethiopia.

this study aims to evaluate the impact of the "doing what matters in times of stress guided" self-help manual on mental distress, business performance, and intimate partner violence experienced by women entrepreneurs in ethiopia. the study will be conducted in four cities - addis ababa, hawassa, bahir dar, and adama - using a randomized controlled trial (rct) design. the investigators will screen 5000 potential participants via phone and enroll 1200 eligible women, who will be equally distributed across the four cities. after an in-person baseline survey, the women will be stratified by marital status and city and randomized into the intervention or waitlist control group using a computer-generated random assignment. the intervention group will receive seven phone-based sessions over ten weeks to review the self-help manual materials with a lay helper. two follow-up surveys will be conducted after the intervention, the first one a month after the completion of the intervention, and the second one twelve months after completion. this study is a continuation of a pilot study conducted between july 2021 and august 2022 (prs registration id - nct05208723). the current study seeks to build on the pilot study in the following dimensions: 1. increase the sample size to 1200 women entrepreneurs to improve the power of the study to detect the impact of the intervention on business performance outcomes, 2. widen the geographical and contextual coverage, 3. allow entrepreneurs to invite a household member to attend the self-help phone sessions with them, 4. capture the impact on intimate partner violence, 5. introduce a short conflict module to capture the direct and indirect effects of conflict on mental health outcomes, business performance, and intimate partner violence.

Eligibility criteria:
inclusion criteria: * age ≥18; * those who plan to live in the study city in the next six months; * those who can read and speak amharic and can understand the study questionnaire; * those who have the capacity to provide informed consent; * score 8 or above on the ethiopian adaptation of kessler-6 exclusion criteria: * kessler 6 score \>20; * those who have recent or current suicidal thoughts or plans; * those who have limitations in understanding the study questionnaire; * those who do not have the capacity to provide informed consent; * do not have access to a phone; * not interested in receiving the intervention

Keywords: stress managment psychological wellbeing business performance intimate partner violence
effects of oral supplementation with creatine on systemic microvascular endothelial function in vegetarian individuals

Conditions: Endothelial Dysfunction; Hyperhomocysteinemia

Summary: the present study aims at investigating the effects of the oral supplementation with creatine on the systemic microvascular reactivity and plasma levels of homocysteine in vegetarian individuals of the vegan type.

a vegetarian is an individual who lives on a diet of grains, pulses, legumes, nuts, seeds, vegetables, fruits, fungi, algae, yeast and/or some other non-animal-based foods, with or without, dairy products, honey and/or eggs. a vegetarian does not eat foods that consist of, or have been produced with the aid of products consisting of or created from, any part of the body of a living or dead animal. this includes meat, poultry, fish, shellfish, insects, by-products of slaughter\*\* or any food made with processing aids created from these. there are different types of vegetarian: i) lacto-ovo-vegetarians eat both dairy products and eggs; this is the most common type of vegetarian diet; ii) lacto-vegetarians eat dairy products but avoid eggs; iii) ovo-vegetarians eat eggs but not dairy products; iv) vegans do not eat dairy products, eggs, or any other products which are derived from animals. vegetarian individuals are considered to have lower cardiovascular risk for the development of cardiovascular diseases and lower cardiovascular mortality, when compared to omnivore individuals. nevertheless, some vegetarian diets may result in the deficiency of micronutrients and induce deficiency in some compounds such as vitamins, amino-acids, iron, zinc, calcium, omega-3 fatty acids and so on. moreover, vegetarian individuals can present deficiency in amino-acids such as carnosine and creatine, present essentially in the skeletal muscle of animals. in this context, deficiency in creatine has been considered as a risk factor for hyperhomocysteinemia and the consequent dysfunction of the vascular endothelium. hyperhomocysteinemia also is known to be an independent risk factor for cardiovascular diseases similar to hypertension, smoke and dyslipidemia. in the present study, we investigate the effects of creatine supplementation in the systemic microvascular endothelial function and density in vegan-vegetarians presenting with normo- or hyperhomocysteinemia using laser-based skin flowmetry and video-capillaroscopy. we also investigate the effects of creatine supplementation on lipid and glycemic profile and plasma homocysteine levels. microvascular reactivity is evaluated using a laser speckle contrast imaging system in combination with the iontophoresis of acetylcholine (ach), for the noninvasive and continuous measurement of cutaneous microvascular perfusion changes. microvascular density in the skin is evaluated using intravital video-microscopy.

Eligibility criteria:
inclusion criteria: * healthy vegetarians of the vegan type exclusion criteria: * previous treatment with dietary supplements * high intensity physical activity

Keywords: vegetarianism hyperhomocysteinemia vegan vegetarian
nutraceuticals versus usual care in the prevention or reduction of cipn in patients treated with docetaxel as neoadjuvant/adjuvant breast cancer therapy

Conditions: Peripheral Neuropathy in Breast Cancer Patient

Summary: the trial will utilize nutraceuticals (vitamin d 2000iu oral once daily, vitamin b6 100 mg oral once daily, vitamin b12 100 mcg oral once daily, omega-3 fatty acids 900 mg oral three times a day) in patients treated with docetacel as neoadjuvant or adjuvant breast cancer therapy. the trial is being conducted to see if the use of nutraceuticals will prevent or reduce chemotherapy induced peripheral neuropathy (cipn).

phase 2, single centre, open-label 2 arm randomized trial. the intervention group will receive a daily dose of vitamin d, omega-3-fatty acids, vitamin b6, and vitamin b12. the reference group will have usual care. dose of nutraceuticals: vitamin d 2000 iu oral once daily, vitamin b6 100 mg oral once daily, vitamin b12 100 mcg oral once daily, omega-3 fatty acids 900 mg oral three times a day (600 mg epa, 300 mg dha) population: breast cancer patients undergoing either neoadjuvant or adjuvant therapy with docetaxel. 106 participants in total will be needed with accrual being completed in hopefully 1 years' time. study investigators will screen the candidates for the study.

Eligibility criteria:
inclusion criteria: * female 18-70 years of age * biopsy proven invasive breast carcinoma * scheduled to receive docetaxel (3-6 cycles) * have values for liver (ast, alt, bilirubin) and renal function (creat), within 1.5 times normal values as drawn per standard of care. * ecog 0-2 * be able to provide informed consent * willingness to adhere to regimen exclusion criteria: * metastatic disease * any peripheral neuropathy * known hiv (testing not required) * diseases causing malabsorption i.e.: inflammatory bowel disease, celiac and whipple's disease * patients with seafood allergies * patients on warfarin or with a documented clinically significant bleeding disorder

Keywords: breast neoplasms peripheral neuropathies
functional antigen matching in corneal transplantation

Conditions: Corneal Diseases

Summary: penetrating keratoplasty is one of the most commonly performed transplantation surgeries. graft rejection is a major complication. hla compatibility has already been demonstrated an effective prophylaxis in several retrospective investigations. the purpose of the investigators randomized clinical trial is to demonstrate superiority of hla matching in comparison to random graft assignment with respect to the endpoint 'time to first endothelial graft rejection' in penetrating keratoplasty. the investigators will perform dna-based allele resolution typing.


Eligibility criteria:
inclusion criteria: * predicted waiting time for a 4/6 match lower than 6 months. exclusion criteria: * minority * legal incapacity

Keywords: penetrating keratoplasty hla matching corneal diseases that require penetrating keratoplasty
significance of an elimination and provocation diet in patients with chronic urticaria

Conditions: Urticaria; Angioedema

Summary: patients with chronic urticaria undertake a five week elimination diet (pseudoallergen free diet). the efficacy of the diet will be determined by symptom score, by the use of rescue medication (oral antihistamines and glucocorticosteroids) and by a quality of life questionnaire on week 0 and week 5. all patients with sufficient response (regarding the urticaria score) enter a second dietary part over six weeks, whereas a provocation diet is carried out. each diet week a choice of pseudoallergen rich food is added, sorted by the type of pseudoallergens (e.g. biogenic amines, organic acids, flavours, additives). this study is conducted to investigate if the provocation diet could be a new diagnostic intervention to elucidate clinical relevant pseudoallergens.

chronic urticaria is defined as a daily or almost daily spontaneous occurrence of wheals that cause itching and lasting for at least six weeks. if there is no indication of a possible eliciting agent and because approximately 70% of patients benefit from it, a low-pseudoallergen diet should be carried out for 5 weeks. although the low-pseudoallergen diet is successful, no explanation of the underlying mechanisms exists. on dbpc oral provocation testing with known food additives, only a small amount of patients, who experienced remission after a low-pseudoallergen diet react with new wheals and/or angioedema. for this discrepancy, natural food ingredients and new food additives are included in the dietary diagnostic. the high amount of substances, which are administrated within oral provocation testing can not reflect a realistic diet situation. often it is impossible to ingest corresponding amounts of foods to reach the same concentration such as the provocation amount. recording change reactions between food ingredients and the individual metabolism of the patients, the "step by step" food provocation method reveals itself to be most effective. in addition, individual predilections, amounts and frequency of ingested foods, are taken into consideration.

Eligibility criteria:
inclusion criteria: * signed informed consent * chronic urticaria (duration: at least 6 weeks) * patients who suffered from urticaria and/or angio oedema at least once a week for a duration of at least 4 weeks) * males and females, age between 7 and 80 years * inpatients and outpatients * oral antihistamines and glucocorticosteroids are allowed as concomitant medication (if needed) exclusion criteria: * pregnant or breastfeeding woman * patients suffering from diabetes mellitus * patients with cachexia * known food allergies of food which will be administrated within the elimination diet (e.g. milk, cereals) * isolated urticaria with known aetiology (e.g. physical urticaria, aquagene urticaria, urticaria factitia, cholinergic urticaria), urticaria pigmentosa mastocytoses) * patients, seemed to be uncompliant under suspicion of the investigator

Keywords: low pseudoallergen diet elimination diet provocation diet oral provocation natural food ingredients food additives flavours