Kornimate/medical-research-clean huggingface dataset:
hypoallergenicity of a hydrolyzed rice protein-based formula in infants and young children with cow's milk protein allergy

Conditions: Cow's Milk Protein Allergy

Summary: the purpose of the study is to determine whether a new hydrolyzed rice protein-based formula is hypoallergenic in infants and young children with documented immunoglobulin e (ige)-mediated cow milk protein allergy (cmpa).


Eligibility criteria:
inclusion criteria: 1. written informed consent has been obtained from at least one parent (or legally acceptable representative \[lar\]), if applicable) 2. child gestational age ≥ 37 completed weeks 3. child aged ≥ 60 days and less than 36 months at enrollment 4. documented ige-mediated cmpa no more than 6 months prior to enrollment 5. child is receiving a strict cow's milk elimination diet and will continue receiving this diet until the completion of the study 6. child's parent(s) and lar (if applicable) is of legal age of majority, must have parental authority, must understand the informed consent form and other study documents, and are willing and able to fulfill the requirements of the study protocol exclusion criteria: 1. child is exclusively breastfed 2. any chronic medical diseases (except atopic eczema), chromosomal or major congenital anomalies 3. congenital heart disease or treatment by b-blockers 4. major gastrointestinal disease / abnormalities (other than cmpa) 5. known or suspected soy allergy 6. glucose-galactose malabsorption 7. immunodeficiency 8. children who are unable to discontinue antihistamine use (excluding eye drops) within 7 days prior to a food challenge and oral steroid use within 14 days prior to enrollment 9. persistent wheeze or chronic respiratory disease 10. severe uncontrolled eczema or urticaria 11. rice protein allergy or intolerance (e.g., rice protein-induced enterocolitis syndrome), or allergy to any ingredient in the formulas 12. child's parent has other medical or psychiatric condition that, in the judgement of the investigator, would make the child inappropriate for entry into the study 13. currently participating or having participated in another interventional clinical study within 4 weeks prior to enrollment 14. child's parents have not reached legal age of majority (18 years).
analysis of endocavitary electrical signal and surface electrocardiogram to predict ablation outcome in persistent atrial fibrillation

Conditions: Atrial Fibrillation

Summary: background : despite recent progress in the management of patients with atrial fibrillation (af), af remains one of the main risk factor of stroke, heart failure and cardiovascular mortality in the world. af is the most common cardiac arrhythmia, and its prevalence is expected to grow in the coming years. catheter ablation (ca) of af can be successful in restoring and maintaining sinus rhythm (sr) in patients with paroxysmal, and persistent af. haissaguerre et al. have shown that af ablation of the heart by isolating the pulmonary vein is usually sufficient. however, when ablating persistent af patients ablating pathological regions in the atria is also required. ca is still a challenging procedure, and reported success rate for persistent af patients remains relatively low (around 60%). this procedure is associated with risks inherent to any invasive cardiac procedures. a better identification of good responders would reduce the risks associated with ablation, especially for patients with low odds of favorable outcome, while also increasing the success rate of the procedure. it has been shown in the literature the long-term ca outcome can be predicted non-invasively by atrial fibrillatory wave (f-wave) amplitudes. hypothesis : we assume that a morphological analysis of the f-waves on standard twelve ecg will allow for a better ca outcome prediction. objectives : the aim of this study is to automatically analyse the morphology of the ecg signal before a ca procedure, extract relevant features for an accurate prediction of long-term ca outcome for patients in persistent af.


Eligibility criteria:
inclusion criteria: * patients for which clinical data, along with the ecg signals before and during the ca procedure are available, * patients who underwent a first ablation procedure for persistent af exclusion criteria: * ecg data is not interpretable * patients who underwent a second or umpteenth ablation procedure for persistent af
validation of watchbp office ankle-brachial index (abi) function

Conditions: Hypertension

Summary: measurement of the ankle-brachial index (abi) with the oscillometric device watchbp office will be assessed compared to the reference method (doppler). ninety three adult subjects assessed for hypertension, treated or untreated, with complete study data were included. data on the presence of cardiovascular (cv) disease and classical cv risk factors were recorded. all the abi measurements of each individual participant will be performed by the same observer in a randomized order (concerning doppler and watchbp)

all study measurements were performed under standardized conditions in a quiet examination room with 10 min rest in the supine position before measurements. ankle-brachial index (abi) was measured manually by doppler and automatically by the oscillometric device in randomized order by a single investigator. manual doppler abi was measured according to the american heart association guidelines using a continuous wave doppler device (hadeco bidop es-100v3, kawasaki, japan) with a 8 mhz probe. systolic blood pressure was defined with a standard mercury sphygmomanometer by the first doppler flow signal while deflating the cuff from a suprasystolic level in brachial, dorsalis pedis and posterior tibial arteries. systolic pressure was determined sequentially for brachial, dorsalis pedis and posterior tibial arteries for each side and abi was calculated for each leg by dividing the highest ankle pressure to the highest arm pressure. automated abi measurement was performed using a validated oscillometric blood pressure monitor designed for professional use in the office (watchbp office device; microlife, widnau, switzerland). this device allows automated simultaneous both arms or arm and leg blood pressure measurements and thereby the calculation of abi. the abi results are displayed on the device screen. the study protocol included three steps: (i) an introductory familiarization automated abi measurement, (ii) three simultaneous oscillometric both arms blood pressure measurements; in case of a consistent inter-arm difference ≥12 mmhg, the arm with the higher blood pressure was selected for the subsequent oscillometric abi measurements (otherwise the right arm was used) and (iii) doppler and automated abi measurement in randomized order; doppler abi was measured once, whereas automated abi calculation included triplicate simultaneous arm-leg measurements performed for each side. the occurrence of five sequential oscillometric errors was defined as a failure of the oscillometric device to measure abi.

Eligibility criteria:
inclusion criteria: * treated or untreated subjects assessed for hypertension exclusion criteria: * atrial fibrillation * incompressible ankle arteries

Keywords: ankle brachial index watchbp office oscillometric measurement
evaluation of the effectiveness of vitamin d supplementation to pregnant women and their infants in pakistan.

Conditions: Vitamin D Deficiency; Pre Eclampsia; Stillbirths; Low Birth Weight; Prematurity

Summary: vitamin d deficiency is wide spread in south asian population and is contributing to burden of disease in this region including pakistan. the relative importance of vitamin d deficiency, mutation in its receptor and maternal and child health has not been established in pakistan and population based studies are required to explore and avert the maternal and neonatal complications and consequences of vitamin d deficiency the trial will evaluate the effectiveness of vitamin d supplementation to pregnant women and their infants. it will be a double blind placebo controlled trial, which will be conducted in a rural district of pakistan.

the investigators are proposing a community based introduction of vitamin d supplementation and we intend to understand the complex relationship between vitamin d, the growth factors and maternal and infant anthropometric variables and hope to unravel the reasons of vitamin d deficiency in our population. the investigators expect that if vitamin d is supplemented to pregnant women and their newborn infants it will inevitably replenish the micronutrient stores and aid to resolve the maternal and neonatal morbidity due to vitamin d deficiency.

Eligibility criteria:
inclusion criteria: * pregnant women from 20-22 weeks of gestation and their infants, who will agree to take part in this study, will be enrolled. exclusion criteria: * pregnant women with pre existing type 1 or type ii diabetes * women with multiple fetuses, babies (twins, triplets) * pregnant women with high level of vitamin d * babies with multiple congenital anomalies * babies with serious birth injury, birth asphyxia and serious infections * low birth weight less than 1.5 * refuse to participate in the study

Keywords: vitamin d effectiveness pregnant women and their neonates
the impacts of theta-burst stimulation on children and adolescents with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: the investigator would like to investigate the impact of theta-burst stimulation over posterior superior temporal sulcus in children and adolescents with autism spectrum disorder


Eligibility criteria:
inclusion criteria: * autism spectrum disorder, confirmed by ados exclusion criteria: * current and past systemic disease * current and past major psychiatric disorders including schizophrenia, bipolar affective disorder and major depressive disorder * current and past brain injuries * intelligence \< 70 * seizure history * pregnant
leveraging eeg for antidepressant prediction with duloxetine and bupropion

Conditions: Major Depressive Disorder

Summary: the leap-db study will be conducted to validate the utility of eeg biomarkers as an aid to antidepressant treatment selection in adults with mdd.

the leap-db study is an 8-week, multicenter, randomized, blinded study to evaluate the performance of eeg-based biomarkers in predicting treatment outcome. study participants will be randomized in a 1:1 ratio to receive either duloxetine or bupropion and followed for 8 weeks.

Eligibility criteria:
inclusion criteria: * male or female, aged 22 or older at the time of informed consent. * diagnosis of major depressive disorder (mdd) based on the structured clinical interview for dsm-5 for depression. * moderate or severe depression on dsm-5 depression criteria items, as assessed by a score of 10 or more on the patient health questionnaire (phq-9) * has not taken either study medications (duloxetine, bupropion) in the current episode * has not received electroconvulsive therapy (ect), transcranial magnetic stimulation (tms), or esketamine treatment in the current episode * provision of personally signed and dated written informed consent prior to any study procedures * agrees to, and is eligible for all biomarker assessments (eeg, neurocognitive testing, activity and sleep monitoring, genetic testing) * fluent in english * ability to complete all assessments independently * stated willingness to comply with all study procedures and availability for the duration of the study exclusion criteria: * diagnosis of bipolar disorder or a psychotic disorder based on the structured clinical interview for dsm-5. * concurrent use of antipsychotics or mood stabilizers * use of hypnotics, anxiolytics or opiate pain medications greater than three days per week and unable to reduce use to three or fewer days per week on an as needed basis * pregnant or breastfeeding * severe impediment to vision, hearing, comprehension, and/or hand movement that interferes with study tasks * active substance use that interferes with ability to consent and/or complete assessments * any contraindication to eeg (e.g. requiring high concentration oxygen) * employees/family of employees of clinic site * participation in another research study that began within less than 2 months prior to the first study visit

Keywords: major depressive disorder eeg biomarker antidepressant duloxetine bupropion
phase iib pilot of atazanavir + raltegravir

Conditions: HIV

Summary: the purpose of this study is to determine if the combination of atazanavir and raltegravir taken together is safe and effective in the treatment of human immunodeficiency virus (hiv).


Eligibility criteria:
inclusion criteria: * human immunodeficiency virus (hiv)-1 positive status * hiv ribonucleic acid (rna) level \>=5000 copies/ml * antiretroviral treatment-naive * absolute cluster of differentiation 4 (cd4) cell count meeting 1 of the following criteria: * \<350 cells/mm\^3 * screening cd4 \>=350 and \<=500 cells/mm\^3 only if at least 1 of the following conditions apply: * screening hiv rna level \>100,000 copies/ml, or * cd4 decline \>50-100 cells/mm\^3/year, or * age \>=55 years * any cd4 cell count, if participant has a history of an acquired immune deficiency syndrome-defining illness * medically stable exclusion criteria: * screening hiv genotype showing resistance to any component of the study regimen (atazanavir, raltegravir, tenofovir/emtricitabine) * hepatitis b or hepatitis c coinfection * history of or current cardiac disease * electrocardiogram findings: * pr interval \>260 msec (severe 1st degree atrioventricular block) * qrs interval \>120 msec

Keywords: combination therapy
low speed drilling versus conventional drilling technique on crestal bone level in maxilla.(group c ) a randomized controlled clinical trial

Conditions: Bone Resorption

Summary: 20 patients were selected requiring implant placement and divided randomly into two groups (10 in each group) * for the study group, starter drill is used to locate the point of insertion as planned then pilot drill is also used to the full desired working length after that all other sequential drills are used at a low speed (50-70 rpm) without irrigation . * in the study group: implant will be inserted in the low speed osteotomy site. * in the control group: implants will be inserted in the conventional prepared osteotomy site. * for both groups there is no surgical guide used. * the flap will then be copiously irrigated with saline in preparation for closure. * the flap will then be closed using interrupted 4/0 resorbable sutures.


Eligibility criteria:
inclusion criteria: * patients restoring missing maxillary teeth with implant placement. * both sexes. * age: 25-45 * mesio-distal dimensions: not less than 6 mm * bone height: not less than 12 mm * bucco-lingual dimensions: not less than 8mm * all measures will be assessed using cbct. exclusion criteria: * sites needing bone grafting or augmentation. * heavy smokers more than 20 cigarettes per day. * patients with systemic disease that may affect normal healing.
pregnancy rates in women with normal uterine cavity with and without cervical abnormalities

Conditions: Intracytoplasmic Sperm Injection ,Hysteroscopicaly Detected Cervical Pathologies

Summary: the aim of our study is to investigate the pregnancy rates in women with normal uterine cavity ,with and without cervical abnormalities.

the cervix is made up of the ectocervix and endocervix and is on average 3-4 cm long and 2.5 cm wide (pardo et al., 2003; mazouni et al., 2005; robert et al., 2013). the ectocervix is the portion of the cervix projecting into the vagina. it is composed of non-keratinized stratified squamous epithelium and is divided into anterior and posterior lips. the squamocolumnar junction is the area where the epithelial cells of the endocervix and ectocervix meet (herfs et al., 2013). in this area, the columnar cells of the endocervix undergo metaplasia to the squamous cells of the ectocervix. the opening of the ectocervix to the vagina is called the external os. although studies of cervical length in non-pregnant women are few, it is acknowledged that the size and shape of both the cervix and the external os differ in women (pardo et al., 2003; mazouni et al., 2005) and vary with age, hormonal changes, parity and surgical treatments to the cervix. further evaluation of any cervical abnormalities by hysteroscopy eg. (choronic cervicitis , microcycstic epethelium ,micropolypi , cervical stenosis) before icsi could address us to a hidden cause of infertility and may improve the pregnancy rates in icsi cycles with prompt medical or surgical managment of such pathologies.

Eligibility criteria:
inclusion criteria: * 1. women between 18 and 38 years old. 2. an indication for ivf/icsi. 3. women with primary or secondary infertility. 4. women with bmi between 20 \& 35. exclusion criteria: * 1. refusal to join the study. 2. untreated tubal hydrosalpinges. 3. poor responders as assessed by afc 4 or less, amh o.8 ng/dl (nice 2013).
safety and efficacy trial of the use of quetiapine fumarate (seroquel®) in the treatment of patients with bipolar depression

Conditions: Bipolar Disorder; Depression, Bipolar

Summary: the purpose of this study is to evaluate the efficacy and safety of quetiapine in the treatment of a major depressive episode in patients with bipolar disorder.


Eligibility criteria:
inclusion criteria: * written informed consent; * bipolar disorder with most recent episode depressed; * outpatient status exclusion criteria: * patients with a current axis i disorder other than bipolar disorder within 6 months of screening; * patients whose current episode of depression exceeds 12 months or is less than 4 weeks

Keywords: bipolar depression
effect of topical application of hypertonic saline on melanoma on its sizes and number.

Conditions: Melanoma (Skin)

Summary: this study evaluates the effectiveness of applying hypertonic saline solution directly on the melanomas in reducing their sizes and/or number.

many previous studies have shown that cancer cells are over-hydrated, and that hyponatraemia exists in many cases of cancer. the cancer cell's viability depends on angiogenesis and formation of blood vessels that carry water and nutrients to the rapidly-dividing cancer cells. this study tests the hypothesis that reducing the water content of melanoma could lead to increasing its tonicity and hence inhibiting its growth. this reduction of water content can be achieved using osmotic pressure differential via applying highly saline solution - made by sodium chloride crystals wet with water - directly on the melanoma for a certain amount of time, thus leading to water withdrawal from melanoma cells. while the surrounding healthy skin cells can sustain temporary dehydration, melanoma cells could be negatively affected.

Eligibility criteria:
inclusion criteria: * patients with clinically-confirmed melanoma (any location and any stage) who have poorly responded to at least one cycle of conventional and standard therapy (chemotherapy, radiation or drug therapy). * age 5 to 80 years old * life expectancy of at least 1 year * can understand and read english * lives in usa. patient who do not meet the inclusion criteria but still wish to participate will be accepted as observational participants, but their melanoma measurements will be not be taken into account when analyzing the study statistically. exclusion criteria: * skin eczema and/or other skin conditions contraindicated to skin dehydration. * ulcers or open wounds close to melanoma * any medical condition that might cause the patient to lose consciousness * participants who are not residents of usa.
external physical vibration lithecbole(epvl) versus traditional treatment for 4-10 mm ureteral stone

Conditions: Ureteral Calculi

Summary: the investigator aims to perform a prospective and randomized controlled trial evaluating the safety and efficacy of external physical vibration lithecbole(epvl) in treating 4-10 mm ureteral stone.

patients with ureteral stones less than 10 mm, would receive observation for stone passage, not requiring immediate surgery. there are many studies evaluating the effect of medical expulsive therapy in treating ureteral stones, including a-blockers, and calcium channel blockers. most of shuties concluded that the benefit of a-blockers might be among those with larger (distal) stones. there is no good method for the removal of upper ureteral calculi, except drinking water and exercising. recently, a new extracorporeal physical vibrational lithecbole (epvl) device named friend-i epvl (zhengzhou fu jian da medical instrument co., zhengzhou, china) has proven to be an effective treatment for upper urinary tract residual calculi. the device was approved by the chinese food and drug administration in 2012. a simple harmonic motion technology in multi-direction was applied. the lateral acceleration was provided by the physical vibration device in the base through the harmonic vibration wave in the horizontal direction, which induces the urinary stone separate with the kidney or ureter, and expands a moving space for the stone. meanwhile, an axial effect was produced to push the stone by the physical vibration device in the handle through the harmonic vibration wave in the multi- direction. so, we think that epvl may be effective in treating ureteral stones.

Eligibility criteria:
inclusion criteria: 1. adults age 18 to 70 years 2. 4-10 mm single ureteral calculi 3. normal serum creatinine 4. asa grading: 1-2 levels. exclusion criteria: 1. pregnant or isolated kidney patients 2. moderate or severe hydronephrosis 3. history of ureteral stricture 4. multiple ureteral stones; 5. acute urinary tract infection 6. those who are taking α-receptor, calcium channel blocker or chinese medicine stone shovel 7. dysfunction of blood coagulation 8. obese patients (body mass index \> 28 kg / m2);

Keywords: ureteral calculi external physical vibration lithecbole (epvl) efficacy safety