Kornimate/medical-research-clean huggingface dataset:
limonene study in women with breast cancer

Conditions: Breast Cancer

Summary: limonene is a major component in the essential oils of citrus fruits. it has demonstrated promising breast cancer preventive and therapeutic effects in preclinical model systems. this early phase clinical study will evaluate the distribution of limonene to the breast tissue and its associated biological activities after 2 to 6 weeks of limonene dosing in women with a recent diagnosis of early stage breast cancer. this study will help evaluate the potentials of developing limonene as a breast cancer preventive agent.


Eligibility criteria:
inclusion criteria: * women who are 18 years of age or older * women electing to undergo excision surgery for early stage breast cancer * a minimum of 2 weeks from enrollment to definitive surgery * underwent core needle biopsy for breast cancer diagnosis * no clinical evidence of metastatic breast cancer * ecog performance status 0-1 * participants must have normal organ and marrow function * women of child-bearing potential must agree to use adequate contraception * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * concurrent chemotherapy or radiation therapy * use of selective estrogen receptor modifiers or aromatase inhibitors within the past 3 months or concurrently * history of other malignancies within the past 5 years excluding non-melanoma skin cancer and cancers confined to organs with removal as only treatment * participated in another clinical intervention trial within the past 3 months * uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * pregnant or breast-feeding women * use of dietary supplement that contains large amounts of d-limonene (such as heartburn free with roh10 and coq with d-limonene) within the past 3 months

Keywords: limonene breast cancer cancer prevention
delving into borderline personality disorder clinical trial experiences

Conditions: Borderline Personality Disorder

Summary: taking part in medical study usually favors a particular demographic group. but there is limited research available to explain what trial attributes affect the completion of these specific demographic groups. this study will admit a wide range of data on the clinical research experience of borderline personality disorder patients to determine which factors prevail in limiting a patient's ability to join or finish a trial. it will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future borderline personality disorder patients.


Eligibility criteria:
inclusion criteria: * aged ≥ 18 years old * clinical diagnosis of borderline personality disorder * able to comprehend the investigational nature of the protocol and provide informed consent exclusion criteria: * no diagnosis of borderline personality disorder confirmed * inability to perform regular electronic reporting * patient does not understand, sign, and return consent form

Keywords: borderline personality disorder
adding nalbuphine for control of intrathecal morphine pruritus

Conditions: Pruritus; Pain, Postoperative; Nausea, Postoperative; Vomiting, Postoperative

Summary: intrathecal morphine causes intense itching which is very bothersome. nalbuphine antagonizes this effect when given intravenously. this trial is to find out if nalbuphine added to intrathecal morphine has an effect on morphine related pruritus while still maintaining adequate analgesia.

the study will be performed in miniauniversity hospitals, after obtaining approval from the local ethics committee. all patients will have a peripheral iv cannula 18 g inserted; standard non-invasive monitors will be applied. patients undergoing major abdominal surgery will be divided into 2 groups to receive intrathecal morphine 300 micrograms with or without nalbuphine 1mg prior to anesthesia. general anesthesia is then given to patients.

Eligibility criteria:
inclusion criteria: * male and female patients. * age 18-80yrs. * elective major abdominal surgery under general anesthesia. exclusion criteria: * refusal to participate. * skin or systemic disease with itching. any condition which precludes performing spinal injection

Keywords: pruritus intrathecal morphine intrathecal nalbuphine
vertical augmentation with osteon at dental implant placement

Conditions: Tooth Injuries; Tooth Abnormalities

Summary: dental implants are a valid and reliable method to replace missing teeth. the major requirement for their success is an adequate volume of bone into which they can be placed. one widely used method to augment bone at the time of placing the implant is to use a bone substitute rather than taking a block bone graft from the patient. successful augmentation in the vertical direction has often proved difficult, however, the investigators have developed a technique to achieve this in the investigators patients using a synthetic bone substitute, osteon (implantium, ce0120) in an attempt to avoid patients having to undergo another unnecessary surgical procedure.

primary objective • to determine the success of dental implants in alveolar bone augmented in the vertical direction with osteon. secondary objectives • to determine the long term success of dental implants in this augmented bone. primary endpoint • radiographically assessed vertical height of alveolar ridge formation following osteon augmentation.

Eligibility criteria:
inclusion criteria: * missing one or two teeth * bounded saddle * healthy (asa grade i \& ii) adult exclusion criteria: * smoker * significant medical problem (asa iii or above)

Keywords: bounded saddles missing teeth dental implants tooth, nonvital
spirometry in mechanically ventilated chronic obstructive pulmonary disease (copd) patients

Conditions: COPD

Summary: patients with copd who deteriorate to respiratory failure pose a challenge to the intensivist both in ventilating an obstructed patient and in weaning from mechanical ventilation. currently there are no accepted extubation criteria in copd patients that could predict successful weaning from mechanical ventilation. in this study we will attempt to correlate spirometric data to eventual weaning from mechanical ventilation.

copd patients who deteriorate to respiratory failure will be recruited. sedation will be interrupted daily, and each day once the patient is awake and cooperative, spirometry will be performed. fev1 and fvc will be recorded and later correlated to eventual rate of successful extubation.

Eligibility criteria:
inclusion criteria: * \>18 * mechanically ventilated due to copd exacerbation exclusion criteria: * decreased level of consciousness * uncooperative patient * bronchial asthma

Keywords: copd spirometry weaning
kegal exercises with and without postural correction on postpartum pelvic organ prolapse in primiparous women

Conditions: Pelvic Organ Prolapse

Summary: to study the effects of kegal exercises with and without postural correction on pelvic organ prolapse in primiparous women. although pregnancy is a physiological process, it is associated with risk factors. these risk factors can put women at risk. one of the most common problems is pelvic floor muscle weakness, and this weakness of pelvic floor muscles causes many other problems, such as pelvic organ prolapse. normal delivery (vaginal delivery) can cause laxity and weakness of ligaments such as the external urethral and pubourethral. pelvic organs prolapse severely affects the quality of life of patients. pelvic organ prolapse appears in women after vaginal delivery. pelvic muscle training is a conservative treatment for many problems, including pelvic organ prolapse. however, the effects of pelvic floor muscle training for pelvic organ prolapse in primiparous women are controversial. this study is aimed at a systematic review of the effects of pelvic floor muscle training on pelvic organ prolapse in primiparous women.

the design of this study will randomize controlled trial. data will collect from the settings of jinnah hospital lahore, thq hospital depalpur, and al-shifa hospital depalpur. the sample size for this study is 30 primiparous women. participants will be screened for eligibility. women will be randomly assigned to the training group, which conducts 12 weekly individual sessions. outcomes will be assessed after the last session. the control group will receive kegal exercise after the initial assessment. main outcome measures for this study include the symptoms pelvic floor impact questionnaire, the pelvic floor distress inventory questionnaire, and the pelvic organ prolapse quantification examination. the pelvic floor impact questionnaire will assess the lifelong impact of pelvic floor disorders on women. a pelvic floor distress inventory questionnaire will assess distress caused by pfd (pelvic floor dysfunction).

Eligibility criteria:
inclusion criteria: * primiparous,age: 20-40, * 6th to 8th week after delivery, * singleton baby vaginally fully term, * non instrumented birth of child, * grade 1 prolapse (5) exclusion criteria: * women with chronic cough, * constipation, * previous pelvic surgery, * pelvic malignancy, * genitourinary infection
diagnostic performance of plasma biomarkers of alzheimer's disease compared with csf markers

Conditions: Alzheimer Blood Biomarkers

Summary: .the goal of this interventional study is to estimate the diagnostic performance of plasma biomarkers of interest (aβ40 and aβ42, p-tau and nfl), enabling discrimination between patients with and without a pathophysiological ad process. the main questions it aims to answer are: * to define a threshold value for each of the plasma, * to describe the correlations between the plasma biomarkers of interest and the other biological analyses performed as part of care, in particular triglyceridemia, cholesterolemia, glycemia and proteinemia, * to describe biomarker results in relation to comorbidities, in particular dyslipidemia and diabetes * to describe the final diagnosis and results obtained for plasma biomarkers, for patients with intermediate results according to the a/t/n classification (a-/t+ or a+/t-) participants will be selected among patients undergoing lumbar puncture for the differential diagnosis of ad at nancy university hospital.


Eligibility criteria:
inclusion criteria: * man or woman aged 18 or over * person affiliated to a social security scheme or beneficiary of such a scheme * person who has received full information on the organization of the research and has signed an informed consent form * person whose care requires a lumbar puncture to measure markers of alzheimer's disease exclusion criteria: * adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice) * an adult unable to give consent * persons deprived of their liberty by judicial or administrative decision * persons under psychiatric care under articles l. 3212-1 and l. 3213-1. * pregnant, parturient or breast-feeding women * persons staying in a health or social establishment for purposes other than research.
ketogenic diet for child epilepsy and seizure control

Conditions: Epilepsy; Seizures; Lennox-Gastaut Syndrome

Summary: twenty to thirty percent of children with epilepsy continue to suffer from seizures, even when treated with currently available anticonvulsant medications. children with lennox-gastaut syndrome (lgs) are particularly handicapped by atonic-myoclonic seizures. preliminary data suggest that even when other medications have failed, these seizures may respond rapidly and dramatically to a high-fat-low-carbohydrate ketogenic diet. the purpose of the study is to assess if the classic ketogenic diet is efficacious in reducing seizure frequency, medication toxicity, and improves quality of life.

the ketogenic diet (kd) is a form of therapy for seizures that involves a brief period of fasting followed by a very carefully controlled high fat-low protein and carbohydrate diet. studies suggest it is useful in children whose seizures could not be controlled by any of the medicines available. this study is designed to test, in a carefully controlled fashion, how well the diet works in children with "drop" seizures. children who experience 15 or more drop seizures each day, despite having used at least two medications, may be eligible to participate. this study requires children to undergo periods of fasting and to maintain a carefully controlled diet. parents of participating children monitor their children's diets and keep daily meal and seizure diaries.

Eligibility criteria:
inclusion criteria: * \>15 myoclonic or atonic seizures a day * eeg with lennox-gastaut pattern exclusion criteria: * \<15 atonic or myoclonic seizures a day * on \>3 medications * previously on diet and/or evidence of metabolic disorder

Keywords: child children epilepsy seizure ketogenic diet lennox-gastaut syndrome lgs
safety and efficacy study of the evoke™ scs system with feedback vs. conventional stimulation

Conditions: Chronic Pain; Back Pain; Pain

Summary: the purpose of this study is to evaluate the safety and efficacy of the saluda medical evoke scs system with feedback control to treat chronic pain of the trunk and/or limbs.


Eligibility criteria:
inclusion criteria: * subject is male or female between the ages of 18 and 80 years. * have been diagnosed with chronic, intractable pain of the trunk and/or limbs, which has been refractory to conservative therapy for a minimum of 6 months. * be an appropriate candidate for an scs trial and the surgical procedures required in this study based on the clinical judgment of the investigator. * be willing and capable of giving informed consent and able to comply with study-related requirements, procedures, and visits. exclusion criteria: * have a medical condition or pain in other area(s), not intended to be treated with scs, that could interfere with study procedures, accurate pain reporting, and/or confound evaluation of study endpoints, as determined by the investigator. * have evidence of an active disruptive psychological or psychiatric disorder or other known condition significant enough to impact perception of pain, compliance of intervention, and/or ability to evaluate treatment outcomes. * have an existing drug pump and/or scs system or another active implantable device such as a pacemaker, deep brain stimulator (dbs), or sacral nerve stimulator (sns). * have prior experience with scs. * have an active systemic infection or local infection in the area of the surgical site. * be pregnant or nursing (if female and sexually active, subject must be using a reliable form of birth control, be surgically sterile, or be at least 2 years post-menopausal). * be concomitantly participating in another clinical study.

Keywords: chronic pain back pain leg pain pain neurologic manifestations nervous system diseases signs and symptoms scs closed loop
two bag system for hydration in diabetes

Conditions: Diabetes; Ketoacidosis

Summary: this is a randomized controlled trial comparing the time needed to get the conditions to space hourly controls to controls every 4 hours, using the one bag system versus the two bags system, in the initial treatment of children with diabetic ketoacidosis. after fast infusion of isotonic saline solution (20 ml/kg) to prevent shock, the administration of maintenance fluids and insulin therapy is indicated. hourly plasmatic levels of glucose controls could determine changes in glucose iv administration. on using the classic one bag system each change determine a bag change. using the two bag system allows to deliver the patient the appropriate glucose infusion in less time.

the treatment of children with diabetic ketoacidosis includes fast infusion of isotonic saline solution to prevent shock (20 ml/kg), and then the administration of maintenance fluids and insulin therapy according to hourly plasmatic glucose levels controls. finally, after patients stabilization, controls becomes less frequents (each 4 hours). during the stabilization period infusion of glucose is calculated hourly according to plasmatic glucose levels. these modifications in iv infusion can be very frequent, sometimes by the hour, requiring preparation of a new solution for hydration (in a new bag). this procedure takes time, during which the patient continues receiving the previous iv infusion until the changes are effectively made. therefore, usually changes are not strictly hourly, interfering with the adjustment of the organism to the above mentioned changes. the 2 bag system consists in using 2 bags with different solutions with the same electrolyte content but different dextrose concentration (0% and 10%), administered simultaneously through the same intravenous line. using this system allows that changes needed in the administration of fluids and/or dextrose, may be easily and instantly managed by delivering different amounts from each bag to achieve the desired infusion rate without having to replace the bag.

Eligibility criteria:
inclusion criteria: * patients between 1 to 18 years old * diabetic ketoacidosis(plasmatic glucose \> 250mg/dl, ph \< 7.3, bicarbonate \< 15mmol/l, ketonuria and glycosuria) exclusion criteria: * patients who already received insulin in the emergency department. * patients who, because of their clinical condition, require admission to intensive care unit.

Keywords: diabetes ketoacidosis children
quality improvement program (qip) to reduce 30-day readmission in malnourished hospitalized patients

Conditions: Malnutrition

Summary: newly admitted patients will be screened for risk of malnutrition. patients will receive either the feeding protocol or current oral nutrition supplement (ons) practice, pending location. patients will continue the nutrition plan taking the supplement post discharge. study team will follow-up with telephone calls to help support post-discharge ons compliance. quality and service utilization data will be gathered for analysis.


Eligibility criteria:
inclusion criteria: * patient is ≥ 18 years of age. * patient is screened for malnutrition with an mst score ≥ 2 (see appendix c). * patient has length of stay of hospital stay \> 2 days. * patient is able to consume foods and beverages orally. * patient receives ensure, nepro or glucerna during the course of his or her hospital stay in connection with the qip. exclusion criteria: * patient is pregnant. * patient is intubated, receiving tube feeding or parenteral nutrition. * patient unable to provide hipaa authorization and informed consent. * patient is discharged to hospice care. * patient has a condition that would preclude ingestion / absorption of the oral nutritional supplements, including allergic response to any ons ingredient. * patient has severe dementia or delirium, brain metastases, eating disorder, history of significant neurological or psychiatric disorder. * patient has stated an allergy or intolerance to any of the ingredients in the study products.
feel breathe, restriction device ventilatory nasal

Conditions: Mouth Breathing; Restrictive Breathing Pattern

Summary: it has patented a restriction and filtering device ventilatory nasal flow feelbreathe with the aim of increase nasal airflow resistance, therefore the objective was to examine the effects of feelbreathe with lung ventilation and gas exchange during exercise.

background: different devices are currently used to train inspiratory muscles, thus showing an increase in the physical performance. it is a control trial to investigate the effects of a new restriction and filtering device ventilatory nasal flow (feelbreathe). methods: a total of 27 trained male caucasian subjects (age: 32.5 ± 7.23 years) were recruited from different sports clubs. measurement of maximum static inspiratory pressure were taken before exercise testing and an incremental test in cycle ergometer to volitional fatigue for the determination of gas exchange data. each subject performed three identical submaximal exercises at 50% of ventilatory thresholds under different breathing conditions: 1) oronasal breathing 2) nasal breathing and 3) nasal breathing with feel breathe, restriction and filtering device ventilatory nasal flow. discussion: researchers try to find if the new device called feelbreathe causes changes in the lung ventilation and gas exchange during exercise. if the results show altered breathing pattern and cardiometabolic variables, feelbreathe could be used to training respiratory muscles.

Eligibility criteria:
inclusion criteria: * age: 25-35 years. * trained male caucasian cyclists * non-smokers * each subject completed an approved informed consent form and detailed health questionnaire before testing. exclusion criteria: * smokers. * presence of diseases during the test period. in particular, they had no current symptoms of nasal disease, snoring, asthma or allergic rhinitis. * unwillingness to complete the study requirements.

Keywords: restriction device ventilatory nasal flow oronasal breathing nasal breathing.
walking ability and limit of stability in children with spastic cerebral palsy

Conditions: Gait, Spastic

Summary: trunk control in children with spastic cerebral palsy (cp) is impaired. they have weaker trunk muscle strenght, and insufficient sitting/standing balance according to their developing peers. since their weak trunk muscles and insufficient balance responses, they are not able to walk as functional similar to their peers. additionaly limit of stability is worsen in children with cp. investigation of the relationship between walking ability and limit of stability when seated position is important to understand which child is acceptable for training of walk. however we did not found any study to explain it. therefore the aim of this study is to investigate walking ability and limit of stability in children with spastic cp, and to compare their developing peers.


Eligibility criteria:
inclusion criteria: * spastic serebral palsy, between the ages 6-15 years, between the i-iv. levels of gmfcs, be able to understand command given by physical therapist exclusion criteria: * undergone botulinum toxin a to upper and/or lower extremities, undergone any surgery to their extremities, be at the v. levels of gmfcs

Keywords: gait, walking ability, limit of stability, cerebral palsy
genetic mechanisms underlying sars-cov-2 infection and the impact of covid-19 on cognitive function

Conditions: Covid19

Summary: there is a considerable variation in the disease behavior in terms of contracting the infection, manifesting none to a range of symptoms and severity of the infection among individuals exposed to or infected with sars-cov-2 virus, the causative organism of covid-19. although the respiratory system appears to be the primary target of this virus infection, emerging evidences suggests involvement of extra-pulmonary organs including central nervous system. we aim to compare the genetic profile of individuals with vs without covid-19 after being exposed to infected cases. additionally, we will assess the cognitive function in covid-19 positive cases with vs. without neurological symptoms at the time of infection and 1-month follow-up using the montreal cognitive assessment (moca) questionnaire.


Eligibility criteria:
inclusion criteria: 1. male or female over 18 years of age at the time of enrollment 2. have symptoms of covid-19 (with or without hospitalization) or contact history 3. willing to undergo nasopharyngeal swab test for viral-rna at baseline (in non-hospitalized cases) and the moca survey at baseline and 1-month follow-up exclusion criteria: 1. unwilling to provide informed consent 2. moca score ≤17 at baseline 3. patients with clinical diagnosis of dementia 4. impaired consciousness