Kornimate/medical-research-clean huggingface dataset:
study of nutritional supplement shakes in people about to receive their debulking surgery for ovarian cancer

Conditions: Debulking Surgery for Ovarian Cancer

Summary: the purpose of this study is to find out if it is possible to establish a nutritional support program for people who are scheduled to receive primary debulking surgery. design: this will be a prospective observational study to assess the feasibility of implementing a preoperative nutrition supplementation program.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * scheduled to undergo primary surgical debulking of ovarian, fallopian tube and primary peritoneal cancer * have a sufficient preoperative window during which the intervention can occur, with the last day of supplementation at least one and no more than two days prior to surgery; scheduling of the procedure should not be delayed due to participation in this investigation exclusion criteria: * have received neoadjuvant chemotherapy * debulking surgery scheduled less than 8 days from initial visit * are scheduled for a minimally invasive procedure * unable to tolerate oral intake or have gastrointestinal issues that would prevent or prohibit oral supplement consumption * have diabetes mellitus * have allergies to the ensure surgery immunonutrition shake supplement * have galactosemia

Keywords: nutritional supplement shakes 19-108
quality of life in survivors of gynecologic cancer

Conditions: Endometrial Cancer; Ovarian Cancer

Summary: rationale: quality-of-life assessment in cancer survivors may help determine the long-term effects of having had gynecologic cancer and may help improve the quality of life for future cancer survivors. purpose: this clinical trial is studying the quality of life in survivors of gynecologic cancer.

objectives: * describe the significant quality of life (qol) concerns and long term survivorship issues of women diagnosed and treated for early stage ovarian and endometrial cancer five or more years ago. * identify mechanisms which contribute to a gynecologic cancer survivorship model through comparison and prediction of high versus low qol associated with long term adjustment and survivorship. examine social support, coping efforts, self-efficacy, meaning associated with survivorship, performance status, and age at diagnosis as potential predictors. * identify and compare factors that predict high versus low qol for women with early stage endometrial cancer completing participation in gog-99 clinical trial. conduct exploratory analysis examining long term qol concerns of survivors randomized to surgery arm with or without radiotherapy. outline: patients complete one telephone interview with a professional female interviewer. the interview lasts approximately 60 minutes and is audiotaped. projected accrual: a total of 197 early stage endometrial cancer survivors and 114 early stage ovarian cancer survivors will be accrued for this study within 2 years.

Eligibility criteria:
disease characteristics: * histologically confirmed early stage ovarian and endometrial cancer survivors treated and diagnosed five or more years ago * patients completing treatment in gog-95 or gog-99 protocols at least 5 years ago with no recurrence of disease * patients with secondary malignancy or under treatment for other medical conditions are eligible patient characteristics: age: * not specified performance status: * not specified life expectancy: * not specified hematopoietic: * not specified hepatic: * not specified renal: * not specified other: * must be capable of completing telephone interview in english prior concurrent therapy: biologic therapy: * see disease characteristics chemotherapy: * see disease characteristics endocrine therapy: * see disease characteristics radiotherapy: * see disease characteristics surgery: * see disease characteristics

Keywords: stage i ovarian epithelial cancer stage ii ovarian epithelial cancer stage i endometrial carcinoma stage ii endometrial carcinoma
can mindful eating improve cholesterol and glucose level

Conditions: Cholesterol; Lipidosis

Summary: this study aims to explore the effectiveness of mindful eating and its effect on cholesterol and glucose level. the participants will be required to get tested for their fasting total cholesterol and blood glucose level for two times. at the first visit, they will be required to complete the survey given and be tested for their fasting total cholesterol and blood glucose level. a recommendation on healthy food intake will be sent to participants. at the end of each week, participants will be required 1) to submit three photos of the meals that they are most satisfied with in terms of healthiness and 2) using the photos to answer a questionnaire about their diet. the photos and completed questionnaire must be submitted to the research investigator each week for a total of 8 weeks. after 8 weeks, participants will be required to get tested for their fasting total cholesterol and blood glucose level in the appointed pharmacy for the second time. it is estimated to require 15-30 minutes of their time weekly.

consistently high cholesterol or/and glucose level pose harmful threat to the body that may cause lethal health conditions (e.g. stroke, cardiovascular diseases). in addition, 3.6 million malaysians are suffering from diabetes, the highest rate of incidence in asia and one of the highest in the world. there is crucial need to find ways to improve the situation. tele-health interventions and mindful eating behaviours are proposed to be effective in improving the levels of cholesterol and glucose. to investigate and explore the intervention, a small-scale randomised controlled trial will be conducted by comparing the effectiveness of mindful eating and the effect on cholesterol and glucose level. students will collect and analyse both quantitative and qualitative data. a small-scale randomised controlled trial will be conducted to compare the effectiveness of mindful eating and the effect on lipid level. subjects will be randomly assigned to intervention or control group. for intervention group, subjects will be required to snap picture of every meal that they consume. at the end of the day, they are required to actively recall and reflect on how healthy they consider their meals to be. the reflection will be submitted to the research team daily together with the taken pictures of meal. as for the control group, subjects will only snap and submit the picture of their meals but without active recall and reflection. subjects are required to return to the community pharmacy after two months to follow-up on their glucose and lipid levels post intervention.

Eligibility criteria:
inclusion criteria: * total fasting cholesterol of at least 5.2mmol/l exclusion criteria: * familial hypercholesterolaemia or pregnant women.
sleep related breathing disorders, anxiety, depression and quality of life assessment in behcet's disease

Conditions: Behcet Syndrome

Summary: assessment of sleep-related breathing disorders, anxiety, depression and quality of life in behcet's disease.

behçet's disease (bd) was first described by turkish dermatologist hulusi behçet in 1937 as a triad of recurrent oral aphthae, genital ulcerations and relapsing uveitis. behçet disease (bd) is an inflammatory vasculopathy with multisystemic involvement. the clinical course usually follows a relapsing-remitting course with heterogeneous clinical manifestations. the complexity of signs and symptoms in bd can disturb an individual's lifestyle by causing limitation in activity. as a result, numerous psychological problems may arise. furthermore, it was shown in some studies that in patients with bd with fatigue, there was a significant association with impaired quality of life. some studies reported the sleep quality in behcet disease is very poor, and restless legs syndrome, fatigue, depression, anxiety, and activity of behcet disease could affect to the quality of life. however, to date, there have been limited studies regarding sleep quality, quality of life, and depression in behcet disease patients. extrapolating that behcet disease, a kind of vasculitis, also affects the sleep quality, it is considered a meaningful study to compare and analyze the relationship between disease activity and sleep quality, quality of life, and depression in egyptian population of behcet disease patients.

Eligibility criteria:
inclusion criteria: * clinical examination and assessment of behçet's disease activity (international criteria for behçet's disease - point score system: scoring ⩾4 indicates behçet's disease). exclusion criteria: * patients who refuse to participate in the study.

Keywords: behcet syndrome sleep disorders anxiety quality of life
celiac disease prevention with probiotics

Conditions: Celiac Disease in Children

Summary: background/aim: celiac disease is a common immune-mediated disorder, and the only currently available treatment is a gluten-free diet. recent studies have shown several probiotics to carry properties that might positively influence the immunological activity in celiac patients. the aim of the present study is to investigate how daily consumption of probiotics would affect levels of tissue transglutaminase autoantibodies (ttga), markers of celiac disease autoimmunity in the periphery, as compared to placebo in children at genetic risk for celiac disease. methods: between 2012 and 2015, 90 children were recruited from two ongoing prospective celiac disease screening studies at the skåne university hospital, sweden. participants were randomized to either daily consumption of 2 lactobacilli strains or placebo for the duration of 6 months. blood samples were drawn at 0, 3 and 6 months and analyzed for both iga-ttga and igg-ttga using radioligand binding assays.


Eligibility criteria:
inclusion criteria: * carrier of any of the hla-types dq2 and/or dq8 associated with celiac disease. * screened positive for tissue transglutaminase autoantibodies (ttga) in at least 2 consecutive blood draws (\<30u/ml). * no celiac disease diagnose * currently on a normal gluten-containing diet exclusion criteria: * screened positive for type 1 diabetes associated autoantibodies (gada, iaa, ia-2a, znt8a).
icare stress management e-training for dementia family caregivers

Conditions: Alzheimer's Disease; Dementia

Summary: photozig and stanford university are creating a program to help cope with caregiving, alleviate related stress, and enhance quality of life for caregivers, with funding from the national institute on aging. this home-based program includes a free dvd, printed materials, and resource website. in addition, after completing the program, participants will have free access to final online resources for 1 year. there are no face-to-face meetings, and participants can live anywhere in the united states.

the goal of this study is to develop the icare program, a dvd/online video training that builds skills and stimulates practice. we are evaluating different materials, which may encourage caregiver participation, enable user interaction, and promote better assimilation of concepts. we are designing the program to help to enhance caregivers' skills to deal with demanding tasks of caregiving, alleviate related stress, and improve quality of life. research program steps: 1. caregivers will be asked some simple questions about themselves and their family members to see if they are eligible for the project (fill out enrollment form and informed consent). 2. a program survey will be sent, which can be completed online, or returned in a pre-mailed envelope. 3. a dvd, materials, link to our website, login information, and instructions will be mailed to participants. we ask participants to watch the dvd, read printed materials, use the website, and follow instructions. materials are expected to help participants in their caregiver role. 4. after completing the program, the second and final survey should be filled out online or returned by pre-mailed envelope.

Eligibility criteria:
inclusion criteria: * care for an individual with alzheimer's disease or other dementia. * own a dvd player or have internet access. * minimum age of 21 years old. * spend at least 8 hours/week caring for a person with dementia, which may include assisting, watching, monitoring, or being available to help (e.g. during sleep time). exclusion criteria: * severe psychological or physical illness. * inability to read and follow english instructions. * high level of depressive symptoms. * unwillingness to participate in all aspects of the study.

Keywords: alzheimer's disease dementia caregiving caregiver coping coping with caregiving stress
anterior cruciate ligament (acl) reconstruction: single bundle versus double bundle

Conditions: Anterior Cruciate Ligament Tear

Summary: acl tear is a common injury among athletes. the recommended treatment includes reconstruction of the ligament. the common reconstruction technique is single bundle reconstruction. however, this technique does not simulate the natural structure of the ligament. the purpose of the study is to compare between the common procedure, single bundle reconstruction with the double bundle reconstruction technique.


Eligibility criteria:
inclusion criteria: * knee instability with a history of acl tear * diagnosed acl tear according to mri * age range 16-40. exclusion criteria: * previous surgery in the knees * multiple ligament raptures * partial acl tear * severe cartilage degeneration * genovaruse/genovalgus * thin hamstrings tendons * oper epiphysis in the knee joint * patient with muscle/neurological problem that increases the tendency to fall

Keywords: arthroscopic surgical procedure
immunoblot, chemiluminescence and immunocap allergen specific ige evaluation of in allergic rhinitis patients

Conditions: Diagnoses Disease

Summary: in the present study the investigators assay house dust mites (hdms) ige in sera of allergic rhinitis patients (ar) using immunoblotting, chemiluminescence, and immunocap assays to compare between the accuracy of both immunoblotting and chemiluminescence assays, and immunocap as gold standard.

all allergic rhinitits patients who were monosensitized to mixed hdms, identified by spt, will be subjected to complete history taking and assessment of the inclusion and exclusion criteria, performance of skin prick test and measurement of total serum ige, measurement of specific ige by chemiluminescence immunoassa, immunoblot assay and immunocap™ phadiatop™. the patients will be followed-up for 6 months.

Eligibility criteria:
inclusion criteria: 1. patient consent. 2. patient with (18-40) years age known to be allergic rhinitis. 3. patient with ige mediated allergic rhinitis (positive total ige). 4. patient with positive skin prick testing and monosensitized to hdm exclusion criteria: 1. patient refusal 2. patients taking oral corticosteroid. 3. patients taking anti-ige injections. 4. patients taking intranasal corticosteroid. 5. patient with non- ige mediated allergic rhinitis. 6. patients with chronic diseases.
use of a modified propofol emulsion in adults

Conditions: Anesthesia

Summary: the purpose of the study is to determine whether a modified propofol preparation shows any effect on the incidence of injection pain in adults undergoing elective surgery under general anesthesia. study hypothesis: the use of a modified propofol preparation will reduce the incidence of injection pain in the study group.

pain on injection is a most frequently reported side effect associated with the use of propofol for induction of anesthesia. various measures have been taken to reduce the pain on injection, e.g. administration of lidocaine or fentanyl prior to propofol administration, mixture of lidocaine and propofol as well as cooling of the emulsion. although pain on injection had been reduced with some of the above mentioned methods, they may not be regarded as a satisfactory solution of the problem.

Eligibility criteria:
inclusion criteria: * male and female adults, age ≥ 18 years and ≤ 80 years * anesthetic risk classified as asa i-iii * patients undergoing elective surgery under general anesthesia * signed informed consent exclusion criteria: * simultaneous participation in another trial * known or suspected drug abuse * known hypersensitivity to propofol, other ingredients of the emulsion, or to any other necessary co-medication * not allowed concomitant medication (psychopharmacologic agents, tranquilizers, or centrally active analgesics) * patients taking lipid lowering drugs * history of decompensated renal failure * history of severe hepatic dysfunction, hepatic cirrhosis * angiographically confirmed chd (coronary heart disease) or cerebral ischemia * history of convulsive disorders * decompensated cardiac insufficiency * hypovolemia * increased intracranial pressure * pregnancy (positive ß-hcg test) and lactation * emergency situation * patient who receives parenteral fat emulsion, e.g. intralipid * patients incapable of giving consent personally * venous access for induction of anesthesia not possible at dorsum of the hand or not dorsal

Keywords: anesthesia induction pain
relationship between q-tip test and urethral hypermobility

Conditions: Urodynamic Stress Incontinence

Summary: q-tip test was applied for evaluation of urethral hypermobility (uh) in stress-incontinent women. it is still unknown whether there is an alternative method for the assessment of uh in a less invasive way or not. we aim to assess the correlation between the overall rest-stress distance measured by transperineal ultrasound (tpus) and q-tip test angle in women with urodynamic stress incontinence (usi) scheduled for mid-urethral sling surgery (mus), and determine a cut off value of rest-stress distance for predicting uh.

between january 2009 and january 2014, women with urodynamic stress incontinence (usi) scheduled for mid-urethral sling surgery in the urogynecological department of a tertiary referral center were recruited. a retrospective chart review was performed. this study received approval from the institutional review board of kaohsiung medical university hospital (id:kmuhirb-e(i)-20210275), by which relevant guidelines and regulations were followed accordingly. informed consent was obtained from all participants before surgeries. the q-tip test was performed via a cotton swab with the patient in a 45-degree reclining. after lubricated with 2% lidocaine jelly, the cotton swab was inserted with the tip over bladder neck. the angle changes from rest to maximal straining were obtained for 3 times, and the maximum of angle change was recorded. the tpus was performed by two experienced urogynecologist according to kmuh-tpus protocol. the voluson general electric sonography, expert 730 type (ge, healthcare ultrasound, zipf, austria) ultrasonography was used with 3.5 mhz curved linear-array transducer placed between the major labia and underneath the external urethral orifice. the measurement was done on the midsagittal plane to obtain the image of pubic symphysis, urethra, and bladder in a view. ultrasonic measurement of the overall rest-stress distance was define as the linear distance of bladder neck position change from resting status to maximal strain. the rest-stress distance was obtained for 3 times, and the maximum of distance was recorded. the primary outcome of this study was the correlation between the angle of q-tip test and the overall rest-stress distance of bladder neck in tpus. the secondary outcome was the optimal cut off value of the rest-stress distance to predict uh.

Eligibility criteria:
inclusion criteria: * women with urodynamic stress incontinence (usi) * scheduled for mid-urethral sling surgery exclusion criteria: * women with more or equal to stage 2 pelvic organ prolapse (pop) defined by pop-quantification system (pop-q) and received concomitant transvaginal mesh (tvm) surgery * women with incomplete ultrasound records

Keywords: urodynamic stress incontinence q-tip test transperineal ultrasound urethral hypermobility
assessment of metabolic profiles of lower extremity arterial disease in patiens withe type 2 diabetes

Conditions: Diabetic Angiopathies; Diabetes Mellitus, Type 2

Summary: the prevalence of lower extremity arterial disease (lead) in patients with diabetes increases significantly and are characterized with obvious arteriosclerosis that are caused by multiple metabolic disorders. metabolomics measures the metabolites in biological fluids or tissues that generated under certain conditions via rapidly evolving high-throughput technology. herein, the investigators designed the study to characterize the serum metabolic profiles of lead patients and identify metabolic biomarkers using metabolomics. the serum of volunteers, type 2 diabetes mellitus(t2dm) patients with or without lead were collected and analyzed using liquid chromatography-mass spectrometry(lc-ms) coupled with a series of multivariate statistical analyses.


Eligibility criteria:
inclusion criteria: * age ranges from 18 to 100 years old * signed informed consent and agreed to participate in this study * the diagnosis of t2dm is based on standard criteria recommended by who since 1999 * the diagnosis of t2dm patient with lead is based on standard criteria recommended by chinese guideline on prevention and management of diabetic foot (2019 edition)(ii). exclusion criteria: * younger than 18 years old or older than 100 years old * acute infection during the preceding 3 months * drugs or alcohol addicts * cancer * type 1 diabetes * patients with mental abnormality who are uncooperative with this study * pregnant or lactating women * refuse to sign informed consent

Keywords: diabetes mellitus, type 2 lower extremity artery disease metabolic profiles metabolic biomarkers metabolomics iquid chromatography-mass spectrometry