Kornimate/medical-research-clean huggingface dataset:
a study of docetaxel and lobaplatin versus docetaxel and carboplatin combination regimen in patients with platinum-sensitive (>6 months) relapsed ovarian cancer

Conditions: Recurrent Ovarian Cancer

Summary: the purpose of this study is to evaluate the effectiveness and security of lobaplatin combined with docetaxel in treatment of the sensitive recurrent ovarian cancer.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 70 years old 2. singed the information consent form 3. expected survival time \>3 months 4. recurrence for at least 6 months after receiving initial platinum-based chemotherapy and without cytoreductive surgery indications. exclusion criteria: 1. recurrence within 6 months after receiving initial platinum-based chemotherapy 2. without radiographic evidence for tumor recurrence 3. receiving other chemotherapy, hormone therapy, immunotherapy, or radiation therapy

Keywords: recurrent ovarian cancer lobaplatin docetaxel carboplatin
testosterone therapy of men with type 2 diabetes mellitus (t2dm)

Conditions: Type 2 Diabetes Mellitus; Hypogonadism

Summary: a randomized, placebo-controlled, double-blinded study on 40 men with type 2 dm. type 2 diabetes mellitus (t2dm) is a common endocrine disorder characterized by hyperinsulinaemia and insulin resistance. hypothesis testosterone therapy increases lean body mass and insulin sensitivity in men with low normal levels of bioavailable testosterone and type 2 dm.

background inadequate levels of androgens have been associated with an increased risk of chronic illnesses including obesity and diabetes. moreover, testosterone treatment has been shown to increase lean body mass and lipid oxidation as well as insulin sensitivity in hypogonadal men.

Eligibility criteria:
inclusion criteria: * male gender age 50-70 * bioavailable testosterone \< 7,3 nmol/l * metformin treatment of t2dm for 3 months or more exclusion criteria: * hba1c \> 9,0 %, bmi \> 40 kg/m2, haematocrit \> 50%, * known malignant disease, psa \> 3 ug/l, nycturia \> 3 times, * abnormal routine blood samples, * severe hypertension, * significant ekg-changes, * wish of parenthood, * active mental illness, * former or present abuse, * severe illness of heart-, lung- or kidney, * primary or secondary hypogonadism.
sexual dysfunction and the quality of sexual life in patients with colorectal cancer and their partners.

Conditions: Colorectal Cancer Patients and Their Partners

Summary: in this project the main focus is on assessing sexual functioning and the quality of sexual life after the treatment of colorectal cancer in patients and their partners. patients and their partners complete questionnaires concerning sexual functioning, quality of life, body image, fatigue, anxiety, depressive symptoms, personality factors, and demographic factors. questionnaires are completed before surgical treatment, 6 weeks, 3 months, 6 months, and 12 months after diagnosis. the results of this prospective study will give insight in 1) the incidence of sexual problems and the extent patients with colorectal cancer and their partners are bothered by these problems across time, 2) the effect of different treatment modalities on sexual functioning, 3) the relation between sexual problems and quality of life, 4) the determinants of sexual problems and the quality of sexual life adopting the biopsychosocial approach of patients with colorectal cancer who have been treated with surgery, radiation and/or chemotherapy, and more specifically to the role of personality and patient factors and sexual functioning/the quality of sexual life.


Eligibility criteria:
inclusion criteria: * patients who are diagnosed with colorectal cancer in one of the participating centra, and their partners are asked to participate in this study prior to treatment. * patients have to be between 18 and 75 years old. exclusion criteria: * disease recurrence at baseline or metastases. * poor expression of the dutch language. * dementia. * history of psychiatric illness.

Keywords: colorectal cancer sexual function sexual dysfunction quality of (sexual) life partners body image anxiety (state and trait) depressive symptoms personality
mechanical ventilation in patients with lung impairment controlled by the mechanical energy of the respiratory system

Conditions: ARDS; Lung Injury, Ventilator Induced

Summary: a project aimed at expanding the monitoring of mechanical energy (me) in patients on mechanical ventilation (mv), with the aim of contributing to reducing the influence of the device for mechanical ventilation of patients on the lung parenchyma by setting parameters that will lead to lower ventilation energy. according to the parameters set on the device for mechanical ventilation, the mechanical energy will be calculated, which the physician in the interventional arm of the study will be able to use to change the mechanical ventilation settings. the physician will follow the best clinical practice, and in the non-intervention group, the mv setting will be conventional.

mechanical ventilation (mv) in patients with acute respiratory failure (arf) is one of the most common causes of hospitalization in the intensive care unit (icu). arf can be associated with severe forms of lung injury, the so-called ards (adult respiratory distress syndrome). despite progress in the management of patients with ards, the mortality of these patients remains high, with in-hospital mortality reaching up to 45%. in patients with severe ards, mechanical ventilation can damage the lung parenchyma and cause ventilator-induced lung injury (vili), which further worsens the patient's prognosis. the result of setting the individual parameters of mechanical ventilation is the energy that the device exerts on the lung parenchyma, which ensures the opening of the lungs and a change in their volume related to gas exchange during breathing. routine laboratory values of blood gases and parameters of inflammation (crp, pct) will be recorded; which is part of routine clinical practice and standard patient care unrelated to the study. as part of a prospective randomized study, a system for monitoring mechanical energy at the patient's bedside will be developed. patients will be randomized into two groups - the intervention arm (mechanical ventilation controlled according to me) and the non-intervention arm (conventional method of conducting mechanical ventilation).

Eligibility criteria:
inclusion criteria: * patients with fully controlled mechanical ventilation * patients older than 18 years * patients with lung disease (pneumonia, ards) * expected duration of mechanical ventilation longer than 48 hours exclusion criteria: * pregnant women, when this fact is stated in the admission protocol * inclusion in the study in a period longer than 24 hours from the start of mechanical ventilation (from admission to the anesthesiology and resuscitation department)

Keywords: mechanical ventilation adult respiratory distress syndrome ventilator-induced lung injury mechanical energy
acupressure versus ischemic release in non-specific neck pain

Conditions: Manual Therapy; Neck Pain

Summary: chronic neck pain (cnp) attributed to myofascial pain syndrome (mfps) which is one of the particularly common skeletal muscle disorder associated with the hyperirritable zone in the taut band of muscle. myofascial trigger points (mtrp) are one of the most overlooked and ignored causes of musculoskeletal pain. this study aims to compare the clinical efficacy of acupressure of cervical acupoints versus ischemic compression release (icr) of mtrps in cnp.

nonspecific neck pain (nsnp) is the commonest cause of neck symptoms and results from postural and mechanical causes.chronic neck pain (cnp) attributed to myofascial pain syndrome (mfps) which is one of the particularly common skeletal muscle disorder associated with the hyperirritable zone in the taut band of muscle. myofascial trigger points (mtrp) are one of the most overlooked and ignored causes of musculoskeletal pain.the objectives of this study is to compare the clinical efficacy of acupressure of cervical acupoints versus ischemic compression release (icr) of mtrps in cnp. this single blind randomized trial involves patients with nsnp were randomly assigned into three groups: the acupressure group (acg), and the ischemic compression release group (icrg) and the control group (cg). patients in all groups received hot packs and post-isometric relaxation. patients in acg received acupressure at local acupuncture points, gall bladder 21 (gb 21), small intestine 14 (si 14) and si 15, and the icrg received pressure on mtrps of trapezius muscle on both sides. vas sores, pressure pain threshold (ppt), neck lateral flexion range of motion, and neck disability index (ndi) were assessed before and after 4 weeks of treatment.

Eligibility criteria:
inclusion criteria: * all participants have nonspecific np for a period of \>3 months * all participants are presented with at least one active mtrp at the upper trapezius muscle, - * all participants had not used any medications or physiotherapy to alleviate pain were included in this study. exclusion criteria: * participants who met these criteria had been excluded: 1. np due to trauma, whiplash, cervical disc prolapse, inflammation, malignant disease, or any other neurological and orthopedic conditions, which will affect the assessment. 2. congenital malformation of the spine as it will alter the normal pattern of movements. 3. had any invasive therapies in the past month. 4. patients with sensory impairments, such as diabetic sensory neuropathy. 5. mental disorders.

Keywords: acupressure; ischemic compression release; neck pain.
transcranial magnetic stimulation and bulimic craving

Conditions: Bulimia

Summary: bulimic patients suffering from binge eating or "craving" a pressing need to eat, with a sense of unease and anxiety, relieved by food intake. the phenomenon of craving bulimia may be considered appropriately by using paradigms developed in the framework of embodied cognition theories. in bulimic, a study with 20 bulimic patients proved an automatic attraction (unconscious) for food in these patients, as measured by reaction time. moreover, a therapeutic explored in bulimia (particularly on reducing craving), is repeated transcranial magnetic stimulation (rtms). studies have shown that a single session of rtms to the dorsolateral prefrontal cortex left (dlpfc) reduces significantly the food craving among bulimics, 24 hours after stimulation. but the therapeutic efficacy of tms on bulimia to more than 24 hours has not yet been demonstrated, and the psycho-cognitive underlying mechanisms have not yet been explored.

the exams / treatments of the study include: * a 20 minute session of rtms at a frequency of 10 hz. * cognitive testing and attention, which will be made on the computer before and 24 hours after the session of rtms. cognitive test consist in , on a computer screen: * is first displayed, food and non-food words. the patient must pull a lever to it if the letter a is present in the word and push the lever if the letter a is missing the word. * then presents a series of food and non-food words. the patient must pull a lever to it if it deems that the word has a positive meaning and push the lever if it determines that the word has a negative meaning

Eligibility criteria:
inclusion criteria: * right-handed patient * patients without psychotropic treatment or treatment with a stable and unchanged for over a month. * normal bmi exclusion criteria: * previous history of seizures or epilepsy. * participants with a somatic problem restricted movement or an uncorrected visual acuity problem. * history of head trauma, neurological disease or unstabilized serious physical illness. * major depressive episode at the time of the study

Keywords: bulimia repetitive transcranial magnetic stimulation (rtms)
a pilot study of empagliflozin in the treatment of acromegalic cardiomyopathy

Conditions: Acromegaly; Cardiomyopathies

Summary: acromegaly is a disease characterized by excess growth hormone(gh) and insulin like growth factor(igf)-1. pituitary gh secreting adenoma is the major cause of acromegaly. acromegalic cardiomyopathy is one of the leading causes of death in acromegalic patients. no efficient medicine is available for acromegalic cardiomyopathy until now and there were limited studies. empagliflozin is proved to decrease the risk of heart failure in diabetic patients and independent of blood glucose control. we planed to evaluate the structure of heart by mri before and after 6 months treatment with empagliflozin in acromegalic patients to investigate the effect of empagliflozin on acromegalic cardiomyopathy.


Eligibility criteria:
inclusion criteria: * patients with pituitary gh adenomas confirmed by surgery active acromegalic patients although treated with surgery,radiation therapy and somatostatin analogs exclusion criteria: * patients with contraindications to empagliflozin pregnant patients patients with poor control of hypertension(sbp\>150mmhg or dbp\>95mmhg patients with contraindications to mri
immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without tace for advanced hcc with vascular invasions

Conditions: Hepatocellular Carcinoma (HCC)

Summary: immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma with vascular invasions

the vascular invasions is a common complication in 16% to 30% of patients with hepatocellular carcinoma (hcc), contributing to poor prognosis and increasing the risk of cancer recurrence, with a median survival of approximately 2.7 to 4 months without intervention. both the european association for the study of the liver and the american association for the study of liver diseases guidelines recommend that hcc patients with vascular invasions be classified as barcelona clinic liver cancer stage c and receive systemic treatments. nevertheless, there is limited data on patients with highly complicated hcc and no optimal treatment strategy for this patient population. tyrosine kinase inhibitors (tkis) and immune checkpoint inhibitors (icis) are commonly utilized in the systemic therapy of hcc, while the combination of transcatheter arterial chemoembolization (tace) with systemic therapy has significantly improved treatment outcomes in advanced-stage patients. therefore, we hypothesized that a triplet regimen comprising tace, tki, and icis may yield better prognoses for hcc patients with vascular invasions. this study aims to compare the safety and efficacy of the triplet regimen of tkis, icis, and tace versus lenvatinib combined with icis in advanced-stage hcc with vascular invasions

Eligibility criteria:
1. has a diagnosis of hcc confirmed by radiology, histology, or cytology; 2. barcelona clinic liver cancer (bclc) stage c with the presence of macrovascular invasion; 3. has not received any previous systemic therapy for hcc (including chemotherapy, molecularly targeted therapy, immunotherapy); 4. both pd-1/pd-l1 inhibitors and anti-angiogenesis drugs patients received only include marketed drugs but are not limited to hcc approval; 5. tace was performed after the first pd-1/pd-l1 inhibitor/anti-angiogenic drug treatment or before treatment (within 3 months); 6. received at least 1 cycle of pd-1/pd-l1 inhibitor/anti-angiogenic drug combination therapy after tace treatment; 7. has repeated measurable intrahepatic lesions; exclusion criteria: 1. cholangiocarcinoma, fibrolamellar, sarcomatoid hepatocellular carcinoma, and mixed hepatocellular/cholangiocarcinoma subtypes(confirmed by histology, or pathology) are not eligible; 2. unable to meet criteria of combination timeframe described above; 3. child-pugh c or ps\>2 or severe hepatic encephalopathy

Keywords: transarterial chemoembolization hepatocellular carcinoma immune checkpoint inhibitors molecular target therapies
supportive oncology care at home rct

Conditions: Pancreatic Cancer; GastroEsophageal Cancer; Rectal Cancer; Head and Neck Cancer; Lymphoma

Summary: this research study is evaluating a program that entails remote monitoring and home-based care for people with cancer who are receiving chemotherapy, radiotherapy, or chemoradiotherapy.

participants receiving treatment for cancer often require multiple care visits and may experience significant symptoms and side-effects related to the cancer and the cancer treatment. this research study is evaluating if a program that involves remote monitoring and home-based care may improve the quality of life, ability to manage symptoms, and overall care of individuals during cancer treatment. remote monitoring is broadly defined as a way of monitor outside of conventional clinical settings (e.g. in the home) that often utilizes technology to increase access to care. eligible participants will be randomized into one of two groups: * usual care or * supportive oncology care at home it is expected that about 300 people will take part in this research study.

Eligibility criteria:
inclusion criteria: * to be eligible, patients must be: age 18 or older * receiving definitive treatment (i.e. neoadjuvant chemotherapy and/or chemoradiation with curative intent) for pancreatic, gastroesophageal, rectal, head and neck cancer, or lymphoma * within two weeks of starting treatment * planning to receive care at massachusetts general hospital (mgh) * verbally fluent in english * residing within 50 miles of massachusetts general hospital exclusion criteria: * patients with uncontrolled psychiatric illness or impaired cognition interfering with their ability to understand study procedures and provide written or electronic informed consent.

Keywords: pancreatic cancer gastroesophageal cancer rectal cancer head and neck cancer lymphoma
observational study of how patients take eye drops

Conditions: Glaucoma

Summary: this study is interested in monitoring how patients take eye drops, both through video-recordings and adherence monitoring, as well as their perceptions about their eye medications; including the dosing schedules, instillation techniques and effect on their disease.


Eligibility criteria:
inclusion criteria: * \>18 year old * currently taking 1 or more hypotensive topical eye drops takes drops in the right eye for more than 6 months expect to continue drop use for the next 3 months * subjects instill their own eye drops * subject is able to take hvf tests * subject will expect to complete the 3 months enrollment period exclusion criteria: * unable/unwilling to instill own medications * eye drops are discontinued * unable to take hvf test * unable to complete follow-up * investigators discontinue subject for safety reasons * not using drops in left eye

Keywords: compliance eye drop administration mems adherence
cancer stem cells in multiple myeloma

Conditions: Multiple Myeloma

Summary: in multiple myeloma "cancer stem" cells can be defined and quantified with flow cytometry. more, these cells can be related to treatment response.

the investigators' hypothesis is that, multiple myeloma plasma cells derivate from principal cells that is called "cancer or progenitor stem cell". in multiple myeloma to define immunophenotyping features of these "cancer stem cells" with flow cytometry and to show their prognostic value and check for any relationship between cancer stem cell quantification and chemotherapy response are main aims of this study.

Eligibility criteria:
inclusion criteria: * new diagnosed or relapsed multiple myeloma * routine bone marrow aspiration will be done exclusion criteria: * bone marrow aspiration is not needed
use of omega-3 fat emulsion (omegaven) in infants with parenteral nutrition associated liver disease

Conditions: Parenteral Nutrition Associated Liver Disease

Summary: babies in the newborn intensive care unit who are dependent upon intravenous nutrition for a long period of time frequently develop liver damage. the fat used is called intralipid and is made from soybean oil. there is a suggestion in the literature that using fish oil based fats called omega-3 fat emulsions can decrease or even reverse this liver damage. we will offer babies with evidence of liver damage and no ability to eat,the omegaven and see if the liver damage reverses.

babies in the newborn intensive care unit with evidence of liver damage from total parenteral nutrition (tpn), as indicated by a direct bilirubin of greater than 2.5 , and who will not be fed for at least another month will be offered the trial. they will be changed from the intralipid to omegaven as the source of their fat. we will continue routine monitoring of their nutrition and liver function.

Eligibility criteria:
inclusion criteria: * infants in the newborn intensive care unit * tpn cholestasis of at least 2.5 mg/dl * anticipated tpn treatment for at least one month * signed informed consent exclusion criteria: * enrollment in another trial * lack of consent

Keywords: parenteral nutrition associate liver disease tpn cholestasis tpn associated liver disease
osaka cardiometabolic epidemiological study: ohtori study part 2

Conditions: Type 2 Diabetes Mellitus (T2DM); Type 2 Diabetes; Diabetes Mellitus; Hypertension; Hyperglycemia; Hyperlipidemia; Dyslipidemia; Hyperuricemia or Gout; Hyperuricemia, Gout; Obesity; Obesity/Epidemiology; Obesity, Abdominal; Central Obesity; Visceral Fat; Chronic Kidney Disease(CKD); Atherosclerosis; Metabolic Syndrome; Hepatic Steatosis; Insulin Sensitivity/Resistance

Summary: the aim of this study is to investigate the relationship between body fat distribution measured by ct scan and related risk factors with the risk of incident metabolic and cardiovascular disease in a prospective cohort study of japanese men and women. the investigators will also investigate novel risk factors for metabolic and cardiovascular disease using molecular weight-based metallomics analysis.

obesity is on the rise worldwide and is the most important risk factor for lifestyle-related diseases, including type 2 diabetes, hypertension, dyslipidemia, metabolic syndrome, ischemic heart disease, cerebrovascular disease, hyperuricemia, and chronic kidney disease. in addition, it has been reported that the distribution of fat is more important than the total amount of fat in the body, and the importance of visceral fat accumulation in the abdomen has been reported. although visceral fat accumulation and insulin resistance have been reported to be important upstream factors in the development of lifestyle-related diseases, the major target organs of insulin are not only adipose tissue, but also extremely important tissues such as muscle and liver, and ectopic fat accumulation in these tissues has attracted attention. however, there are few prospective cohort studies that have evaluated fat accumulation in adipose tissue, liver, and muscle simultaneously. it has been reported that japanese people have more visceral fat than caucasians in the united states, even at the same body mass index level, and are at high risk for type 2 diabetes, so research on japanese people is of great importance. in addition, the role of trace elements in the body is attracting attention. in this cohort study, the investigators will also examine the relationship between trace elements in the body and the prevalence and incidence of lifestyle-related diseases. the purpose of this study is to establish a prospective cohort study that evaluates visceral fat, subcutaneous fat, intrahepatic fat accumulation, and intramuscular fat using computed tomography imaging and to clarify the relationship with lifestyle-related diseases such as type 2 diabetes, hypertension, dyslipidemia, metabolic syndrome, ischemic heart disease, cerebrovascular disease, hyperuricemia, and chronic kidney disease.

Eligibility criteria:
inclusion criteria: - exclusion criteria: * women who may be pregnant

Keywords: type 2 diabetes mellitus hypertension hyperlipidemia dyslipidemia hyperuricemia obesity abdominal obesity visceral fat visceral adiposity chronic kidney disease japanese metabolic syndrome insulin sensitivity insulin resistance