Kornimate/medical-research-clean huggingface dataset:
the efficacy of remote ischemic conditioning on stroke-induced immunodeficiency

Conditions: Acute Ischemic Stroke

Summary: to detect the effects of ric on stroke-induced immunodeficiency and inflammation response in acute ischemic stroke patients

remote ischemic conditioning, consisting of several brief cycles of intermittent ischemia-reperfusion of the arm or leg, may potentially confer systemic protection against prolonged ischemia in a distant organ. numerous reports have confirmed its strongest endogenous neuroprotection against brain injury after stroke, of which the immune mechanisms are majorly involved in ric. at the same time, the inflammation response plays a great role in stroke development, which may expand the infarct area. stroke-induced immunodeficiency can potentiate stroke-associated pneumonia, which is an important cause of death after strokes. in this study, the investigators will assess the effect of ric on stroke-induced immunodeficiency and inflammation response in ais patients.

Eligibility criteria:
inclusion criteria: * age≥18 years old; * confirmed diagnosis of acute ischemic stroke(ais) with onset of symptoms within 48h at recruitment; * nihss score: ≤15; * prestroke modified rankin scale(mrs) ≤2; * subject or his or her legally authorized representative was able to provide informed consent. exclusion criteria: * uncontrolled hypertension (defined as systolic blood pressure ≥200 mmhg); * participation in another device or drug trial simultaneously; * any vascular, soft tissue, or orthopedic injury (eg, superficial wounds and fractures of the arm) that contraindicated unilateral arm ischemic preconditioning; * peripheral vascular disease (especially subclavian arterial and upper limb artery stenosis or occlusion); * women who have a positive pregnancy test; * history of malignancies; * using remote ischemic conditioning within the preceding 1 week; * known infection at admission; * a history of infection or the use of antibiotics, immunosuppressants, or steroids within the preceding 3 months. * other conditions are not suitable for this trial (evaluated by researchers)

Keywords: acute ischemic stroke remote ischemic preconditioning stroke-induced immunodeficiency stroke-associated pneumonia inflammation response
muscle and cerebral oxygenation under evar of aaa: ga vs la

Conditions: Anesthesia

Summary: the purpose of this study is to determine the effect of general versus local anaesthesia on muscle and cerebral oxygenation under evar-treatment in a prospective unblinded randomised controlled trail.


Eligibility criteria:
inclusion criteria: * 18 years or older * scheduled procedure exclusion criteria: * allergies for used local anaesthesia * have had vascular surgery before in the femoral area * the need for thromboendarterectomy in common femoral artery * the need for aortouniiliac stent-graft with cross-over bypass * severe back pain * expected time of surgery more than 1.5 hour * cognitive dysfunction making cooperation during procedure impossible * femoral amputee

Keywords: spectroscopy, near-infrared endovascular procedures local anesthesia general anesthesia
results of the staged surgical approach for management of infected un-united femoral shaft fractures in adults

Conditions: Fracture Non Union

Summary: assessment of the efficacy of the multistage technique in the eradication of infection and achieving the union of traumatic infected femoral un-united shaft fractures in adult patients for one year follow up.

all cases will be treated by the induced membrane technique in two stages. in the first stage, thorough debridement of the infected bone and soft tissues and copious lavage will be done. after radical debridement, primary fixation will be done by either external fixation or antibiotic cement coated internally fixed implants.if there is a bone defect, it will be measured and filled with an antibiotic-impregnated (pmma) cement spacer. the second stage procedure will be performed 4 to 8 weeks after the first one if soft tissue permits and only if there is no clinical or biochemical evidence of ongoing infection as indicated by normal white blood cell count, c-reactive protein, and erythrocyte sedimentation rate. it includes the exchange of the antibiotic cement spacer by a cancellous bone graft.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 65 years old. 2. type 32 according to arbeitsgemeinschaft für osteosynthesefragen classification in adults. exclusion criteria: 1. patients with deficient soft tissue coverage with exposed bone. 2. patients with reflex sympathetic dystrophy. 3. spinal injuries associated with neurological complications affecting the lower limbs. 4. associated head injury affecting the conscious level or the motor power of the injured limb. 5. associated mutilating limb injury or peripheral amputation. 6. bone defect more than 6 cm in length. 7. chronic peripheral ischemia of the limb. 8. past history of pathological fractures.

Keywords: infected non-union
endoscopic full thickness resection of gastric subepithelial tumors (frost)

Conditions: Gastric Neoplasms; Gastrointestinal Stromal Tumors

Summary: prospective observational trial. a full thickness resection of gastric subepithelial tumors is performed after application of full thickness sutures underneath the tumor with the gerdx(tm) device. hypothesis: this endoscopic method is feasible, effective and safe.


Eligibility criteria:
inclusion criteria: * presence of a subepithelial gastric tumor with signs of potential malignancy in endoscopic ultrasound * age 18 years or older * participant has given informed consent exclusion criteria: * tumor size \> 40 mm (endosonographic measurement) or large extramural tumor mass * signs of systemic dissemination of tumor * current presence of a different neoplastic disease (except after successful curative treatment without continued medication) * former surgery or disease of esophagus or stomach that impedes insertion of the suturing device * moribund patient * limited possibility to give informed consent (e.g. language barrier, psychiatric disease) * pregnancy and lactation period
radiation planning study for high grade brain tumors

Conditions: High Grade Glioma

Summary: the purpose of this research study is to see if a higher strength mri procedure provides better images to use in planning radiation treatments for patients with brain tumors in the future.


Eligibility criteria:
inclusion criteria: * histologically confirmed, newly diagnosed grade iii-iv glioma * planning to undergo radiation therapy exclusion criteria: * grade i or ii glioma * patients unable to undergo mri imaging
theta-burst neuromodulation for ptsd

Conditions: Chronic Post-Traumatic Stress Disorder

Summary: the purpose of the proposed study is to evaluate initial feasibility and efficacy of theta burst transcranial magnetic stimulation (tbs) as an adjunct treatment for veterans with ptsd. primary outcomes measures include a feasibility of tbs procedures, with secondary outcome measures focusing on changes in ptsd symptom severity and quality of life and social/occupation functioning.

the purpose of the proposed study is to evaluate the feasibility of theta burst transcranial magnetic stimulation (tbs) as an adjunct treatment for veterans with ptsd. this project will result in development of methods needed to conduct an adequately powered, randomized controlled study of tbs for ptsd, which will assess the relationship between change in symptoms and quality of life. it will also lay the foundation for subsequent rehabilitation studies combining neuromodulation and psychotherapy in the longer term. tbs has several advantages compared to standard repetitive transcranial magnetic stimulation (rtms), including its ability to deliver large numbers of stimulation pulses in a shorter time period, and a stimulation pattern that may specifically affect key brain regions involved in ptsd. the significance of this research is the development of a novel, non-invasive brain stimulation approach for ptsd recovery. this project will provide the foundation for the development of methods needed to conduct an adequately powered, randomized controlled study of tbs for ptsd to ultimately develop brain stimulation techniques that can be combined with evidence-based psychotherapy, to develop a more powerful, individualized rehabilitation option for veterans with ptsd.

Eligibility criteria:
inclusion criteria: * diagnosis of chronic ptsd according to dsm-5 criteria * veteran (male or female) * age between 18-70 years * clinically symptomatic despite ongoing stable treatment regimens for at least 6 weeks prior to study procedures * capable of independently reading and understanding patient information materials and providing informed consent exclusion criteria: * cardiac pacemaker * implanted device (deep brain stimulation) or metal in the brain * cervical spinal cord * or upper thoracic spinal cord * pregnancy/lactation, or planning to become pregnant during the study * lifetime history of moderate or severe traumatic brain injury (tbi) * current unstable medical conditions * current (or past if appropriate) significant neurological disorder, or lifetime history of: * seizure disorder * primary or secondary cns tumors * stroke * cerebral aneurysm * primary psychotic disorder * bipolar i disorder * active moderate/severe substance use disorders (within the last month, excluding nicotine/caffeine * active suicidal intent or plan

Keywords: quality of life post-traumatic stress disorder transcranial magnetic stimulation feasibility studies
the effect of weight loss on serum mannose-binding lectin(mbl) levels

Conditions: Obesity; Weight Loss

Summary: high levels of mannose-binding lectin (mbl), an activator of a part of the immune system called the complement system, have been associated with increased mortality and risk of early signs of kidney damage in patients with type 2 diabetes. the effect of weight loss and changes in insulin resistance on mbl levels have been poorly elucidated. this study includes 36 nondiabetic obese subjects, who will receive a very low- calorie diet (vlcd) of 800 kcal/day for 8 weeks. fasting blood samples will be obtained at baseline and after 8 weeks of vlcd and concentrations of mbl, glucose and insulin will be measured. insulin resistance is assessed using the homa-ir method.


Eligibility criteria:
inclusion criteria: * obese exclusion criteria: * diabetes * other severe disease

Keywords: obesity weight loss very low-calorie diet mannose-binding lectin insulin resistance
diagnostic accuracy of the dpp ii assay

Conditions: Acute Febrile Illness; Melioidosis; Diagnoses Disease

Summary: burkholderia pseudomallei is responsible for melioidosis, a disease that can present a range of signs and symptoms and can be treated by a specific drug regimen. diagnosis of melioidosis is made by isolation of the bacteria from body fluids or tissues such as blood, skin or sputum. although this is considered the gold standard, bacterial isolation has low diagnostic sensitivity, requires specific infrastructures (biosafety level 3 laboratories) and skilled staff that are not always available in lmics. this may lead to inappropriate patient management and care. chembio, in partnership with find, has developed a multiplex lateral flow immunoassay (dpp® fever panel ii assay) that is able to detect antigens from common causes of febrile illnesses, included burkholderia. find will conduct a laboratory study in menzies health school of research to estimate the diagnostic accuracy of the dpp ii assay using retrospective samples that are positive for b. pseudomallei. results will help in estimating the diagnostic accuracy of the assay for this pathogen.


Eligibility criteria:
inclusion criteria: - samples that can be included in the trial must have been collected exclusively during the "assessment of a new rapid diagnostic test for melioidosis" study (hrec 04/09) conducted by the menzies school of health research. they must be well-characterized with confirmation of presence or absence of b. pseudomallei by bacterial culture. exclusion criteria: * samples with volume \<120 µl * samples collected during projects other than the hrec 04/09 project
a novel myocardial impedance mapping system for ablation of post-infarction ventricular arrhytmias in humans

Conditions: Ventricular Arrythmia; Infarction, Myocardial

Summary: precise identification of the infarct scar is essential for successful catheter ablation of ventricular arrhythmias in patients with chronic myocardial infarction. voltage mapping of endocardial electrograms is currently used to delineate the necrotic scar but this is influenced by the direction of the activation wave front and is not sensitive enough to differentiate distinct degrees of transmural injury in the scar. mapping of local myocardial electrical impedance may overcome these limitations.

clinical series: patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias will be submitted to mapping of both voltage and tissue impedance. likewise, the accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. the impedance system is already constructed and certified for clinical research use.

Eligibility criteria:
inclusion criteria: * more than 18 yearts * chronic myocardial infarction * undergoing ventricular ablation of ventricular arrhythmias exclusion criteria: * patients with device not suitable for cardiac magnetic ressonance (cmr) * pregnacy

Keywords: electrical impedance cardiac radiofrequency ablation
perioperative troponin i and nt pro-bnp in lung resection

Conditions: Cardiac Ischemia; Thoracic Cancer; Complication,Postoperative

Summary: after lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery. integrating both cardiac biomarkers may improve the predictive value for cardiovascular complications after lung resection.

objectives: to evaluate the incidence and magnitude of perioperative n-terminal pro brain natriuretic peptide (nt-probnp) and high-sensitivity troponin i (tn i) elevation in patients undergoing pulmonary resection and its predictive value for cardiovascular complications. methodology: prospective, multicenter, observational cohort study in patients \>45 years undergoing elective thoracic surgery for lung resection. cardiac biomarkers tn i and nt-probnp will be measured preoperatively and at postoperative days 1 and 2. risk score for major cardiovascular postoperative complications will be calculated depending of both biomarkers perioperative changes.

Eligibility criteria:
inclusion criteria: * age ≥45 years old * patients undergoing elective surgery for lung resection exclusion criteria: * patients undergoing urgent, emergent, or nonthoracic surgery * patients or family did not consent to participate * presence of symptoms related with infection or sepsis * patients with a documented history of severe heart failure and/or ejection fraction lower than 30%
an alternative approach to improve hyperglycemia among type 2 diabetes patients

Conditions: Type2 Diabetes

Summary: the study compared the effect of bitter melon intake and moderate exercise on postprandial glucose levels as measured by incremental area under the curve (iauc) in eight patients with type 2 diabetes.

background: this study compared the effects of bitter melon intake and moderate-intensity physical activity on postprandial glucose responses in type 2 diabetic patients. methods: a total of 8 patients with type 2 diabetes were randomly assigned to two sequences (ab, ba) with two treatments (a or b) using a 2 x 2 randomized cross-over design: a) 100 ml of bitter melon juice administered 15 minutes prior to the 75-g oral glucose load; b) 30 minutes walking at moderate-intensity performed 15 minutes after the oral glucose load.

Eligibility criteria:
inclusion criteria: * an age of 20 to 79 years * physician-diagnosed type 2 diabetes * medical clearance for physical activity from their healthcare provider exclusion criteria: * pregnant or were receiving insulin treatment * an allergy to bitter melon * medical conditions that impacted the normal the functioning of the gastrointestinal tract * contraindications to physical activity
comparison of two rescue therapies for helicobacter pylori infection

Conditions: Helicobacter Pylori Infection

Summary: from the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.

the h pylori-infected adult patients with failure of standard triple therapy and h pylori-infected adult patients with failure of non-bismuth quadruple therapy are randomly assigned to either ealt (esomeprazole 40 mg b.d., amoxicillin 500 mg q.d.s., levofloxacin 500 mg o.d., and tetracycline 500 mg q.d.s.) therapy or eal (esomeprazole 40 mg b.d., amoxicillin 500 mg q.d.s., and levofloxacin 500 mg o.d.) for 10 days. repeated endoscopy with rapid urease test, histological examination and culture or urea breath tests is performed at six weeks after the end of anti-h pylori therapy.

Eligibility criteria:
inclusion criteria: * positive results of both rapid urease test and histology, * a positive result of urea breath test, * or a positive result of culture. exclusion criteria: * ingestion of antibiotics, bismuth, or proton pump inhibitor（ppi）within the prior 4 weeks, * patients with allergic history to the medications used, * patients with previous gastric surgery, * the coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia), * pregnant women

Keywords: helicobacter pylori eradication rate rescue treatment
study of xp-8121 for the treatment of adult subjects with hypothyroidism

Conditions: Hypothyroidism

Summary: this is a non-randomized, open-label, single arm, self-controlled study of xp-8121 (levothyroxine sodium) to determine a target dose conversion factor from stably dosed oral levothyroxine to xp-8121 (levothyroxine sodium) in patients with hypothyroidism and to assess the safety and tolerability of xp-8121(levothyroxine sodium) after once weekly subcutaneous injections. this study includes the following periods: screening, titration period, and maintenance period. the study will conclude with an end of maintenance visit or early termination (et) visit.

this is a non-randomized, open-label, single arm, self-controlled study of xp-8121 (levothyroxine sodium) to determine a target dose conversion factor from stably dosed oral levothyroxine to xp-8121 (levothyroxine sodium) in patients with hypothyroidism and to assess the safety and tolerability of xp-8121 (levothyroxine sodium) after once weekly subcutaneous injections. this study includes the following periods: screening, titration period (2 to 8 weeks), and maintenance period (4 weeks). a pharmacokinetic substudy will be conducted for a subset of patients during the maintenance period. the study will conclude with an end of maintenance visit or early termination (et) visit.

Eligibility criteria:
inclusion criteria: * provide written informed consent. * male or female between the ages of 18 and 65 years (inclusive) at screening, with chronic hypothyroidism and on a stable dose of oral levothyroxine (synthroid or an fda-approved generic equivalent to synthroid) or, if in the pharmacokinetic substudy, synthroid only for at least 3 months. * tsh within the normal range at screening (central laboratory) and at least 3 months prior to screening (documented by local laboratory). * free thyroxine within the normal range at screening (central laboratory). exclusion criteria: * history of hypersensitivity to levothyroxine (any formulation). * current dose of oral levothyroxine, based on body weight \>2 μg/kg/day. * current levothyroxine total daily dose either \ 375 μg. * current use of combined thyroid treatment (i.e., synthroid plus liothyronine or synthroid plus armour thyroid) and/or any other levothyroxine aside from those used in the study.
chronic cardiovascular and gut-bacteria effects of phenolic rich oats in adults with above average blood pressure

Conditions: Healthy

Summary: in this proposed human trial, the investigators aim to establish whether 4 weeks of daily consumption of beta-glucan matched meals providing either a high dose or a moderate dose of oat avenanthramides and phenolic acids leads to dose-dependent chronic improvements in markers of cvd risk and gut health relative to an energy matched control intervention in healthy adults with above average blood pressure.

* to investigate the chronic effects of daily intake of oat products on flow mediated dilatation of the brachial artery (fmd; primary endpoint), microvascular endothelial function (measured by laser doppler iontophoresis), pulse wave analysis, gut microbiota diversity, 24h blood pressure, activity of the renin angiotensin system, markers related to cellular production of nitric oxide and reactive oxygen species, inflammatory cytokines, and further potentially emerging biochemical markers of cvd risk. * to establish if phenolic acids and avenanthramides from oat products exert cardiovascular and microbial effects in a dose dependent manner. * to measure urinary and fecal excretion of avenanthramide and phenolic acid metabolites. to explore correlations between bacterial population changes and cvd risk markers.

Eligibility criteria:
inclusion criteria: * above average blood pressure (i.e. systolic 120-159 mmhg and diastolic 75-99 mmhg) exclusion criteria: * abnormal biochemical, haematological results as assessed at health screening * hypertension (i.e. sbp/dbp ≥160/100 mm hg) * bmi \>35 * current smoker or ex-smoker ceasing \<3 months ago * past or existing medical history of vascular disease, diabetes, hepatic, renal, haematological, neurological, thyroidal disease or cancer * prescribed or taking lipid lowering, antihypertensive, vasoactive (e.g. viagra), anti-inflammatory, antibiotic or antidepressant medication * allergies to whole grains * parallel participation in another research project * having flu vaccination or antibiotics within 3 months of trial start * chronic constipation, diarrhea or other chronic gastrointestinal complaint * on a weight reduction regime or taking food, probiotics or prebiotics supplements or laxative within 3 months of trial start * performing high level of physical activity (i.e. ≥150min aerobic exercise/week) * consumption of ≥21 units of alcohol/week * females who are breast-feeding, may be pregnant, lactating or, if of reproductive age and not using a reliable form of contraception (including abstinence)

Keywords: oat phenolic acid avenanthramide fmd ldi gut microbiota blood pressure renin angiotensin nitric oxide
effect of action observation physical training on quality of upper limb and functional independence in children with hemiplegia

Conditions: Hemiplegic Cerebral Palsy

Summary: 30 children with a diagnosis of hemiplegic cerebral palsy

children aged 6-9 years were randomized into 2 groups, control group and study group

Eligibility criteria:
inclusion criteria: * manual ability classification system level ii or iii, modified ashwarth scale 1+ or 2 exclusion criteria: * visual or auditory problems ,fixed deformities

Keywords: hcp