Kornimate/medical-research-clean huggingface dataset:
evaluation of post-covid 19 patients who receive ozonetheraphy with thorax ct

Conditions: Ozone Therapy for Covid 19 Pneumonia Patients

Summary: it is known that enhances wound healing by oxidative stress and supports immune system besides it is cheap and has not any side effects. aim of the study is to prevent pulmonary fibrosis by using ozone therapy as a supportive therapy on the patients who have pneumonia and ground glass opacity on thorax ct both in icu and wards. patients will follow for a year.

the patients accepted with the diagnosis of pneumonia in gaziosmanpaşa treh, both in icu and wards have treated with additional ozone therapy beside the normal treathments. in these patients the findings like ground glass opacity in thorax ct regarding to covid 19 were progressed or non changed. in the concern of these opacities turn to pulmonary fibrosis, ozone therapy has used to prevent this undesirable effect. it is known that enhances wound healing by oxidative stress and supports immune system besides it is cheap and has not any side effects. 25 patients included this study. the patients were diagnosed with covid-19 pneumonia and treated with ozone therapy in intensive care unit and ward. after treatment was done, findings of at least %20-25 ground-glass opacity on thorax ct were the main criteria for enrollment. the patients' follow-up program time after hospital discharge will be on 1st, 3rd, 6th and 12th month. they will continue to recieve ozon therapy once in a month during one year follow up. ground-glass opacity rate of thorax ct scan will be recorded as less then %25, %25-50, %50-75 and above %75. tomographies will be compared with each other and also last thorax ct before hospital discharge. these tomographies will be applied under 80 kv and this will give %40 less dosage according to routine 120 kv scans. if there is an increase in ground-glass opacities compared to the previous one, the scan will be done again on prone position and suspected lesions will be reevaluated. the pulmonary fibrosis findings of the scan will be diagnosed by a well trained radiology doctor. the evaluation of dyspnea will also done during follow-ups. mmrc(medical research council) dyspnea scale will be used for dyspnea status. spo2 values in room-air will also recorded. fev1, fvc and fev1/fvc values will also be recorded to demonstrate respiratory functions.

Eligibility criteria:
inclusion criteria: * over 18 years covid 19 pneumonia patients who have ground glass opacity on thorax ct, receiving ozone as adjuvant therapy. exclusion criteria: * pregnant patients patients who doesnt treated with ozone(hyperthyroid,pulmonary hypertension, right ventricule failure,glucose 6 p dehydrogenase defficiency

Keywords: ozone covi̇d 19 pulmonary fibrosis
immunogenicity and safety of meningococcal (a, c, y and w135) conjugate vaccine

Conditions: Meningitis

Summary: the purpose of this observer-blind study is to evaluate the safety, reactogenicity and immunogenicity of meninggococcal (a,c,y and w135) conjugate vaccine in 2 months to 6 years-old children.


Eligibility criteria:
inclusion criteria: * subjects who the investigator believes will comply with the requirements of the protocol should be enrolled in the study. * healthy permanent residence 2 months to 6 years old. * subjects and parent/guardian able to attend all scheduled visits and comply with all study procedures. * axillary temperature ≤37.0 ℃. exclusion criteria: * history of meningitis infection or vaccination of meningococcal vaccine within the past 6 months. * allergic history or any sae after vaccination, such as allergy, urticaria, dyspnea, angioedema, celialgia. * patients administered with immunosuppressive agents, cytotoxicity factor or corticosteroids in the 6 months preceding the vaccine trial. * receipt of blood or blood-derived products in the 3 months preceding vaccination * participation in another clinical study investigating a vaccine, drug in the 30 days preceding vaccination. * receipt of any live virus vaccine in the 15 days preceding vaccination. * receipt of any subunit vaccine and inactivated vaccine in the 7 days before vaccination. * febrile illness (temperature ≥ 38°c) in the 3 days or any acute illness/infection in the 7 days preceding vaccination. * thrombocytopenia. * history of thyroid gland excision or treatment for thyroid gland disease in last 12 months. * functional or anatomic asplenia. * history of eclampsia, epilepsy, encephalopathy and mental disease or family disease. * chronic disease (such as down syndrome, diabetes, sickle cell anemia or neurologic disease, guillain-barre syndrome). * known or suspected diseases, including: respiratory system disease, acute infection or active stage of chronic disease, hiv infection of children or mothers, cardiovascular disease, acute hypertension, cancer treatment, skin disease, etc. * any condition that, in the judgment of investigator, may affect trial assessment.

Keywords: immunogenicity, safety, meningococcal conjugate vaccine
ngs-based assay of blood samples of sepsis patients for rapid bacterial identification

Conditions: Pneumonia; Acute Pyelonephritis; Bacteremia; Biliary Tract Infection

Summary: rapid detection of microorganisms is a promising approach towards early administration of appropriate antibiotics for sepsis. this study aims to investigate the potential of a new ngs platform for the rapid diagnosis of circulating bacteria in blood.

early start of antimicrobials is the cornerstone of management of critically ill patients. the appropriate time window for this early intervention may vary greatly, but it is considered to be one to 3 hours from hospital admission. however, the choice of the antimicrobials for early intervention relies on empirical selection and may several times be inappropriate due to the emergence of antimicrobial resistance. the only way to overcome this difficulty is guidance through early microbial identification and antibiotic susceptibility testing (ast). however, blood cultures are positive in almost 20% of critically ill patients and ast may delay as much as 72 hours. this means that another type of approach is warranted which will tackle the major limitation of standard-of-care (soc) microbiology, namely, the need to incubate whole blood into flasks enriched with growth media which necessitates subculturing once a blood flask turns positive. it is evident that rapid identification of the pathogen followed by ast using whole blood without the need of blood culture can be a major advance in the diagnostic field. the present study is based on previous analysis of ethylenediaminetetraacetic acid (edta) whole blood coming from patients with known bloodstream infection. next generation sequencing (ngs) of bacterial dna extracted from whole blood managed to identify the correct pathogen. this study is aiming at the validation of this ngs -based assay in a broader number of patients.

Eligibility criteria:
inclusion criteria: * age equal to or above 18 years. * both genders. * written informed consent provided by the patient or by one first-degree relative/spouse in case of patients unable to consent. * patients with high suspicion of infection with at least one sign of the quick sofa score (i.e. one of mental confusion, more than 22 breaths per minute or systolic blood pressure less than 100mmhg). exclusion criteria: * age below 18 years. * denial for written informed consent. * patients already receiving antibiotics. * pregnancy or lactation.

Keywords: bacterial infection antimicrobial susceptibility testing next generation sequencing blood culture time to pathogen identification
stronger together global registry

Conditions: Spinal Disease

Summary: a global, prospective, non-randomized, multicenter, observational, post-market, medical record review registry evaluating real-world evidence for seaspine products.

to gain observational, prospective, real-world clinical, and radiographic data in order to evaluate continued safety and performance following the implantation of seaspine products.

Eligibility criteria:
inclusion criteria: * have been treated with at least one seaspine product. * have obtained radiographic imaging, as part of the standard of care, at the following time points: preoperative and postoperative. * have obtained at least one preoperative patient-reported outcome measure, as part of the standard of care. * patient is planned, per standard of care, to be assessed with radiographic imaging and consistent patient-reported outcome measure(s) from preoperative through at least two scheduled follow-up visits. exclusion criteria: * was not implanted with at least one seaspine product during operation * any other condition that the investigator determines is unacceptable for enrollment into this registry
comfort level after transfemoral coronary angiography

Conditions: Coronary Disease

Summary: with the increase in the number of cardiovascular diseases, the safety of the angiography method used in diagnosis and treatment becomes important. the transfemoral approach is often preferred during angiography. it is recommended to have bed rest for 6-12 hours after transfemoral angiography (tfa) to prevent possible complications. in order to reduce the complications arising from angiography, it is predicted from the studies that giving the patient a therapeutic position, elevating the head of the bed and gradual early mobilization will reduce the patients' groin pain, prevent urinary retention and increase patient comfort. in this study, the effect of gradual mobilization after transfemoral angiography on the vital signs, complications and comfort level of the patients. it is planned to be done to determine the


Eligibility criteria:
inclusion criteria: * individuals who can be contacted at a level that can answer research questions * individuals with transfemoral angiography exclusion criteria: * those with hypertension * individuals with psychological and neurological disorders * patients with communication problems * patients with deterioration in hemodynamics after angiography

Keywords: comfort coronary angiography vital signs
" fume events in air flights: consequences on cabin air quality and on aircrews health of a french fleet of aircraft"

Conditions: Neurologic Symptoms; Neurologic Disorder

Summary: the subject of the study focuses on commercial aircraft's cabins air quality, under conditions of both fume events and non-fume events. it also delves into the immediate and delayed repercussions of these events on the health of aviation crew members. the expological facet of this study is directed at the detection and quantification of organophosphorus compounds originating from engine oils. the epidemiological facet is geared towards the identification of potential neurological consequences.

the study has two components, one in the field of expology and the other in epidemiology. the first part will involve instantaneous atmospheric measurement of organophosphorus additives in oils, namely tcp isomers, txp isomers (commercially available) and tbp, during any fume event, using a portable device developed for this type of event (pre-positioned on all aircraft), over a short time span (around 1 h). an identical measurement campaign will be systematically carried out on a "control" flight free of fume event, within a week. the aim of this experiment is to sample all fume event (around 100) occurring over a period of 12 months and as many fume event free flights. at the same time, carbon monoxide will be measured along with organophosphates during the event. in parallel with these measurements, a "flight self-questionnaire" will be compiled on flight characteristics and cabin environmental conditions will be completed by the flight's in-charge. the second epidemiological phase will take place in two stages. each measurement, whether or not it concerns event or not, will be coupled with a systematic self-questionnaire collection of symptoms experienced during the flight, reported by exposed and non-exposed flight crews. (t0), no later than 72 hours after the end of the flight. in addition, in order to identify acute and delayed neurological impairment and to assess cognitive functions, each subject included (exposed and unexposed) will perform : * a self-assessment within 72 hours (phase 1) and 3 months later (phase 2) of their neurocognitive performance using the cantab (cambridge neuropsychological test automated battery) coupled with a self-assessment of fatigue and anxiety levels using self-questionnaires. * a medical consultation 3 months later (phase 2), including a standardized medical check-up with neuromuscular and neurosensory tests, self-questionnaires and neurocognitive evaluation identical to those used in phase 1. phase 2 is carried out three months after exposure, in order to investigate effects with a latency up to 5 weeks after exposure.

Eligibility criteria:
inclusion criteria: * be of legal age (18 years) * have signed the consent form exclusion criteria: * be pregnant * be over 67 years of age

Keywords: fume events aircrew air quality organophosphorus compounds occupational exposure
flamenco music therapy in pregnant

Conditions: Pregnancy; Music; Therapy

Summary: the use of music as a therapy for the psychological and emotional improvement of pregnant women has been well studied. our hypothesis is that flamenco music can also involve psycho-emotional improvements in pregnant women

the objective of the study is to analyze the effects of a flamenco musical intervention on the stress and anxiety of pregnant women in five management units of the sanitary district in bahía de cádiz-la janda (spain). 50 pregnant women will voluntarily participate in this study (25 in a control group and 25 in the experimental group) the psychological health assessment will be measured through the perceived stress scale (pss), the state-trait anxiety inventory (s-stai) and the edinburgh postnatal depression scale (edps) pre and post exposure.

Eligibility criteria:
inclusion criteria: * volunteer * single pregnancy * uncomplicated pregnancy, * expectations of vaginal delivery without complications * gestational age between 18 and 33 weeks, exclusion criteria: * visual disorders * hearing disorcers * mental or cognitive disorders * difficulties in pregnancy, * medical complications, * smoker during the gestation period

Keywords: pregnant anxiety depression. flamenco music
efficacy of topical azelaic acid 15% gel plus anti-inflammatory dose doxycycline or metronidazole gel 1% plus anti-inflammatory dose doxycycline in moderate papulopustular rosacea

Conditions: Papulopustular Rosacea

Summary: subjects with moderate papulopustular rosacea will be treated either with azelaic acid 15% gel topically plus an anti-inflammatory dose of doxycyline (40mg) daily or with metronidazole 1% gel topically once daily plus an anti-inflammatory dose of doxycycline (40mg) over at total of twelve weeks to determine the rapidity of improvement, and the length of time to reach 25%, 50% and 75% clearing compared to baseline.

the change in inflammatory lesion count will be assessed at each post-baseline visit by an analysis of variance model (anova) with factors treatment and center, but not including treatment-by-center interaction. investigator's global assessment (iga) of papulopustular rosacea (static score): 0 - clear (virtually no rosacea ie, no papules and/or pustules; no or residual erythema; no or mild to moderate degree of telangiectasia may be present); 1 - minimal (rare papules and/or pustules; residual to mild erythema; mild to moderate degree of telangiectasia may be present); 2 - mild (few papules and/or pustules; mild erythema; mild to moderate degree of telangiectasia may be present); 3 - mild to moderate (distinct number of papules and/or pustules; mild to moderate erythema; mild to moderate degree of telangiectasia may be present); 4 - moderate (pronounced number of papules and/or pustules; moderate erythema; mild to moderate degree of telangiectasia may be present); 5 - moderate to severe (many papules and/or pustules, occasionally with large inflamed lesions; moderate erythema; moderate degree of telangiectasia may be present); 6 - severe (numerous papules and/or pustules, occasionally with confluent areas of inflamed lesions; moderate or severe erythema; moderate or severe degree of telangiectasia may be present).

Eligibility criteria:
inclusion criteria: - moderate papulopustular rosacea (iga\>4) with a minimum of 10 and no more than 50 inflammatory lesions and persistent erythema with or without telangiectasia exclusion criteria: * sensitivity to any of the treatments used * co-existing conditions that would unfavorably influence the course of the disease * pregnant or lactating women * severe rosacea

Keywords: rosacea
tumor monitoring using thermography during radiation therapy

Conditions: Malignancy

Summary: this research aims to investigate the correlation between tumor temperature difference and biological factors, such as size, metabolism, treatment response, and tumor aggressiveness. in addition, normal tissue response to adjuvant radiation therapy in treated organs following surgery, will be evaluated.

during radiation session, the investigators would evaluate the changes that will be detected by thermal imaging and correlate them with visible side effects as well as with known tumor biology factors and skin-tumor distance.

Eligibility criteria:
inclusion criteria: * signed informed consent * will undergo radiation therapy for palliation or curative intent due to cancer, biopsy proven exclusion criteria: * not eligible to sign informed consent
effects of music beat on motor function in individuals at risk for psychotic onset and schizophrenia patients

Conditions: Schizophrenia; Psychosis; Parkinsonism; Dyskinesias

Summary: the purpose of this project is to investigate whether a 3-week training program involving music beat (serving as a type of rhythmic auditory stimulation) reduces the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients. it is hypothesized that the program is effective in reducing the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients.


Eligibility criteria:
for at-risk participants: inclusion criteria: 1. a score of or above 9 in the chinese version of the 16-item prodromal questionnaire (cpq-16), or a score of or above 8.18 in the chinese version of community assessment of psychic experiences with 15 items (cape-c15), or a score of or above 17 in schizotypal personality questionnaire-brief (spq-b); 2. an age of 13 years or above; 3. score \> 60 in the chinese version of edinburgh handedness inventory (ch-ebi) to ensure right handedness; and 4. score ≥ 22 in montreal cognitive assessment hong kong version (hk-moca) to ensure no serious cognitive deficits so that they can understand instructions. exclusion criteria: 1. psychiatric diagnosis by self-report; 2. cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements; 3. taking psychiatric medications; 4. substance abuse; and 5. being pregnant. for schizophrenia participants: inclusion criteria: 1. a diagnosis of schizophrenia without other psychiatric diseases; 2. the age ≥ 18 years; 3. score \> 60 in ch-ebi to ensure right handedness; and 4. score ≥ 22 in hk-moca to ensure no serious cognitive deficits so that they can understand instructions. exclusion criteria: 1. cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements; 2. substance abuse; and 3. being pregnant.
pharmaco-economic study of a new medical device performed from the perspective of the hospital

Conditions: Hematologic Disease

Summary: the purpose of the study is to determine whether the use of mouthwashes caphosol ™ in addition to standard oral care (strategy a) is cost-effective in the prevention and treatment of severe mucositis in adult patients with auto or allograft packaging without ict versus mouthwashes standard bicarbonates with an antiseptic (strategy b).


Eligibility criteria:
inclusion criteria: * patients \> 18 years patient receiving: * conditioning of autologous bone marrow transplantation by high dose melphalan (hd) as part of the management of myeloma or beam in lymphoma. * a conditioning allogeneic bone marrow transplantation with reduced or intermediate busulfan iv * patients belong to a schema of social security, having signed the written informed consent. exclusion criteria: * patients: * to receive or have received kgf * with previous history of rt with the exception of patients who received spinal analgesic therapy in the treatment of myeloma * unable or unwilling to complete the self assessment questionnaire * with previous history of allergy to any component of the products under consideration * minor * adults under guardianship * pregnant women * patients who have not signed the consent form * creation of mouthwash out of the study

Keywords: hematologic disease candidates for autologous or allogeneic bone marrow
the fate of calf perforators after endovenous laser ablation of saphenous veins

Conditions: Venous Insufficiency

Summary: the aim of this study is to evaluate the morphologic and hemodynamic changes in the calf perforators after endovenous laser ablation of saphenous veins.


Eligibility criteria:
inclusion criteria: * symptomatic patients who undergo evla procedure for saphenous vein insufficiency exclusion criteria: * patients with a history of deep venous thrombosis (dvt) * previous varicose vein surgery or injection sclerotherapy * patients without superficial venous incompetency
massage with senna-based laxatives versus senna-based laxatives in managing overflow retentive stool incontinence

Conditions: Massage

Summary: this study aimed to evaluate the effect of abdominal massage with senna-based laxative in managing overflow retentive stool incontinence in pediatrics.

much attention has been devoted to children with overflow retentive stool incontinence (orsi) by the pediatric surgeons, as the referral of such cases from pediatric facilities is constantly increasing. an important initial step in managing these children is the exclusion of hirschsprung's disease starting by water-soluble contrast enema. conservative management of oris is generally successful. the aim of the treatment is to achieve and maintain regular bowel movements free of symptoms laxatives remain the mainstay of maintenance therapy of orsi; yet, there is no standard laxative therapy despite the varieties of medication currently available. new information to these queries can be beneficial to medical staff involved in managing overflow retentive stool incontinence in pediatrics, possibly it may add new guideline of treatment with more good result , short time and decrease the laxative dose.

Eligibility criteria:
inclusion criteria: * pediatric patients with orsi according to rome iii criteria * contrast enema suggestive of fecal loading * the absence of anatomic, physiologic or pathologic reason for their constipation exclusion criteria: * radiological suspicion of hirschsprung's disease, * anorectal malformation, * mechanical obstruction, * failed to comply with the offered treatment (mainly if cramping abdominal pain or vomiting occurred), * required bowel surgery. * spina bifida, spinal cord injury,

Keywords: constipation laxatives massage
effects of watermelon juice on heart rate recovery and post-exercise muscle soreness

Conditions: Heart Rate Recovery

Summary: the purpose of this study was to determine the effects of a pre-exercise, single practical dose of watermelon juice, gatorade, sugar water or water on heart rate recovery, blood lactate levels, and 24-hour post exercise muscle soreness.


Eligibility criteria:
inclusion criteria: * ages of 21-50 healthy adults exclusion criteria: * suffering from injury * chronic inflammatory conditions * required dietary supplement use * required medication which affects blood pressure * smoking * pregnant woman * allergy to watermelon