Kornimate/medical-research-clean huggingface dataset:
enhancing behavioral treatment for women with pelvic floor disorders

Conditions: Pelvic Floor Disorders; Anxiety; Urinary Urgency; Urinary Incontinence; Nocturia; Urinary Frequency/Urgency; Lower Urinary Tract Symptoms; Urinary Hesitancy; Urinary Straining

Summary: the purpose of this proposal is to test a novel behavioral treatment - unified protocol cognitive-behavior therapy (up-cbt)1 - to enhance quality of life in women with pelvic floor disorders. emotional distress is treatable using behavioral procedures, and effective treatment would increase women's emotional health and help to reduce urinary symptoms (e.g., incontinence, frequent urination). women with pelvic floor disorders are often seen in the urogynecology clinic, which makes this setting ideal for offering additional interventions that may improve their quality of life. unfortunately, many women with pelvic floor disorders may not receive effective behavioral treatment, such as cognitive behavior therapy, because urogynecologists and other medical professionals may not be aware of providers in their community who offer this treatment. the investigators will enhance treatment options by 1) providing evidence for an all-purpose cognitive-behavioral intervention (i.e., up-cbt), 2) offering treatment in the urogynecology clinic, maximizing convenience, and 3) improving clinical outcomes for these patients. specific aims: 1. to demonstrate that up-cbt is an effective form of therapy for women with lower urinary tract symptoms. 2. to use baseline characteristics in moderation analyses to determine which women will be most likely to have a good response to therapy. 3. to use mediation analyses to test a possible causal chain of events - does treatment lead to lower anxiety, which in turn leads to fewer urinary symptoms?


Eligibility criteria:
inclusion criteria: * female * age 18 years or older * presence of one or more of the following urinary symptoms in past 12 months and currently seeking treatment: frequency, nocturia, urgency, leakage, hesitancy, straining, or dribbling * willing and able to provide informed consent * anxious presentation and/or history of anxiety * english speaking * willing to defer usual treatment for urinary problems exclusion criteria: * blood in the urine, positive urine culture, signs of infection * pregnant, or 6 months or less postpartum * psychosis, dementia, or other cognitive impairment that would preclude participation * recent (within 6 months) pelvic or endoscopic surgery, urethral stricture, pelvic malignancy, current chemotherapy or other cancer therapy, pelvic device or implant complication * recent (within 12 months) botox injection to the bladder or pelvic structures * currently in psychotherapy * current alcohol or substance use disorder * difficulty communicating in english
microelectrode brain-machine interface for individuals with tetraplegia

Conditions: Tetraplegia; Spinal Cord Injury

Summary: the purpose of this research study is to demonstrate the safety and efficacy of using two neuroport arrays (electrodes) for long-term recording of brain activity.

individuals with tetraplegia (paralysis caused by illness or injury that results in partial or total loss of use of the arms and legs) have intact brain function but are unable to move due to injury or disease affecting the spinal cord, nerves or muscles. brain-machine interface (bmi) technology is based on the finding that with intact brain function, neural signals are generated even though they are not sent to the arms, hands and legs. by implanting electrodes in the brain, individuals can be trained to send neural signals which are interpreted by a computer and translated to movement which can then be used to control a variety of devices or computer displays.

Eligibility criteria:
inclusion criteria: * limited or no ability to use both hands due to cervical spinal cord injury or brainstem or spinal stroke * at least 1 year post-injury * live within 1 hour of the university of pittsburgh and be willing to travel to the university of pittsburgh once per week for bmi training * additional inclusion criteria must also be reviewed exclusion criteria: * certain implanted devices * presence of other serious disease or disorder that could affect ability to participate in this study * individuals who are immunosuppressed or who have conditions that typically result in immunocompromise * additional exclusion criteria must also be reviewed

Keywords: tetraplegia spinal cord injury brainstem or spinal stroke neuroprosthetic brain-machine interface brain-computer interface neural activity
radiation therapy in treating patients with aggressive fibromatoses

Conditions: Desmoid Tumor

Summary: rationale: radiation therapy uses high-energy x-rays to damage tumor cells. purpose: phase ii trial to study the effectiveness of radiation therapy in treating patients who have aggressive fibromatoses.

objectives: * determine the efficacy of moderate-dose radiotherapy, in terms of local control, in patients with aggressive fibromatoses. * determine the acute and late side-effects of this regimen in these patients. outline: this is a multicenter study. patients receive radiotherapy 5 days a week for 5.5 weeks for a total of 56 gy in 28 fractions. patients are followed every 3 months for 2 years and then every 6 months thereafter. projected accrual: a total of 40 patients will be accrued for this study within 3 years.

Eligibility criteria:
disease characteristics: * histologically confirmed aggressive fibromatoses arising in any site * primary, recurrent, or progressive disease that is inoperable or requires a major operation resulting in a large functional or cosmetic deficit or mutilation * progressive disease defined as at least 20% increase in tumor size on 2 mri scans within 1 year after any prior therapy except radiotherapy or * incompletely resected tumor with gross residual disease not suitable for further surgery * resected within the past 3 months * lesions must be suitable for radiotherapy * no bulky intra-abdominal disease in close relation to small bowel * measurable disease patient characteristics: age: * 16 and over performance status: * not specified life expectancy: * not specified hematopoietic: * not specified hepatic: * not specified renal: * not specified other: * no conditions that would preclude study follow-up prior concurrent therapy: biologic therapy: * not specified chemotherapy: * prior chemotherapy allowed * no concurrent chemotherapy endocrine therapy: * prior endocrine therapy allowed * no concurrent endocrine therapy radiotherapy: * see disease characteristics * no prior radiotherapy to indicator lesion surgery: * see disease characteristics * prior surgery allowed other: * no prior isolated limb perfusion with tumor necrosis factor * no concurrent isolated limb perfusion with tumor necrosis factor

Keywords: desmoid tumor
tracheal intubation with collar immobilisation : a comparison of glidescope and fastrach

Conditions: Injury of Cervical Spine

Summary: intubation must be done with utmost care in cervical trauma patients. cervical spine motion must be minimized and intubation must be fast. the aim of this study was to compare the effectiveness of fastrach and glidescope. 18-65 years of age , asa i-ii 100 patients undergoing elective surgery were enrolled in this trial. after standard monitorisation including ekg , noninvasive blood pressure, pulse oximetry, anesthesia was induced with propofol and fentanyl. rocuronium was then administered for muscle relaxation. patients were divided into two groups glidescope and fastrach. rigid collar was placed then patients were intubated with one of these devices. mask ventilations with or without collar were recorded. insertion times, intubation times of the devices were recorded. peroperative hemodynamic parameters and postoperative minor complications were also recoded.

inclusion criteria: asa i-ii , 18-60 years of age undergoing elective surgery requiring intubation exclusion criteria: - pregnancy reflux nonfasted head and neck tumors recent flue in 2 weeks

Eligibility criteria:
inclusion criteria: * 18-65 years of age * asa i-ii * requiring intubation * bmi\<35 exclusion criteria: * less than 18 or higher than 65 * asa iii-iv * bmi\> 35 * pregnant * head and neck tumors

Keywords: cervical spine intubating laryngeal mask airway glidescope videolaryngoscope collar
a phase 1 study of human monoclonal antibodies, brii-196 and brii-198

Conditions: COVID-19

Summary: this is a phase 1 study in which healthy adult volunteers will receive brii-196/brii-198 or placebo and will be assessed for safety, tolerability, and pharmacokinetics.


Eligibility criteria:
inclusion criteria: 1. subject must be 18 to 49 years of age inclusive 2. body weight ≤100 kg and body mass index (bmi) within the range of 19.0-26.0kg/m2 (inclusive). 3. male or female exclusion criteria: 1. any clinically significant chronic or acute medical condition that makes the volunteer unsuitable for participation. 2. a history of significant hypersensitivity, intolerance, or allergy to any drug compound 3. history of alcohol or other substance abuse

Keywords: covid-19 phase i monoclonal antibody
star-life: a post-market registry on miniject

Conditions: Open Angle Glaucoma

Summary: as part of the post-market clinical follow-up (pmcf), this registry is developed to ensure real-world data collection on miniject device.

the goal of the registry is to collect data of the miniject in a real-life setting. the registry has 3 main objectives: the collection of real-world evidence on the usability of the device, the patient reported outcomes, and the device safety over a period of 2 years after surgery.

Eligibility criteria:
inclusion criteria: * 18+ years * diagnosed with open angle glaucoma, who has been or will be implanted with ce-marked miniject * able to give consent exclusion criteria: * eyes with angle closure glaucoma * eyes with traumatic, malignant, uveitic or neovascular glaucoma or discernible congenital anomalies of the anterior chamber angle * patients with known intolerance or hypersensitivity to silicone * patients unable to give consent

Keywords: open angle glaucoma minimally invasive glaucoma surgery miniject
a smartphone-based intervention for diabetes prevention in overweight chinese adults with pre-diabetes

Conditions: Pre-diabetes

Summary: type 2 diabetes (t2dm) is a serious chronic condition and one of the world's fastest growing health problems. the onset of t2dm is gradual, with most individuals progressing through a state of pre-diabetes, which provides an important window of opportunity for the prevention of t2dm and its complications. this project aims to translate the evidence-based diabetes prevention strategies into community setting and utilize mobile health technology to reduce diabetes risks in hong kong.

type 2 diabetes (t2dm) is a major global health issue and the cost to community is high and escalating. the asia-pacific region carries a high disease burden, with more than 60% of the global diabetic population living in asian region. the onset of t2dm is gradual, with most individuals progressing through a state of pre-diabetes. a national survey conducted in china in 2010 revealed that 50.1% of people aged 18 or older have pre-diabetes. people with pre-diabetes, defined as having impaired fasting glucose (ifg), impaired glucose tolerance (igt) or elevated glycated haemoglobulin (hba1c) , are at increased risk of developing t2dm and its associated complications, such as heart diseases and retinopathy, which can develop even in the absence of progression to overt t2dm. hence, it is essential that people with pre-diabetes are targeted for early intervention to prevent t2dm and related complications. obesity is a major risk factor for developing t2dm. international trials demonstrate that lifestyle interventions (which includes diet, physical activity and behavioural modification components) targeting at least 5% weight loss in individuals with pre-diabetes can reduce 3-year diabetes incidence by 58%. growing evidence suggests that smartphones may be a promising platform for delivery of behavioural lifestyle intervention to achieve weight loss. this project aims to translate the evidence-based diabetes prevention strategies into community setting and utilize mobile health technology to reduce diabetes risks in hong kong.

Eligibility criteria:
inclusion criteria: * individuals aged 40 - 60 years old * overweight (bmi ≥ 23kg/m2) or obese (bmi ≥ 25 kg/m2) * with at least one blood test result showing igt (7.8-11.0 mmol/l after a two-hour glucose tolerance test), ifg (fasting glucose 5.6 - 6.9 mmol/l) or impaired hba1c 5.7% - 6.4% * owns a smartphone * able to read chinese and speak cantonese. exclusion criteria: * with current or clinical history of t2dm, or with co-morbid conditions that may limit participation in the study, such as recent history of an acute cardiovascular event, uncontrolled hypertension, cancer or major psychiatric or cognitive problems * already participating in a weight loss programme * receiving drug treatment for pre-diabetes or long-term use of medicines known to influence glucose metabolism (e.g. corticosteroids)

Keywords: diabetes prevention pre-diabetes weight loss cardio-metabolic risk obesity lifestyle intervention smartphone-based
assessment of gingival thickness using colored periodontal probe

Conditions: Gingival Phenotype

Summary: the accuracy of different assessment methods of the gingival tissue thickness can be controversial affecting their correct classification and the techniques of gingival tissue management in case of mucogingival problems. aim: the aim of this study is to evaluate the accuracy of different assessment methods of measuring gt and to classify into the different gingival phenotypes.

the accuracy of different assessment methods of the gingival tissue thickness can be controversial affecting their correct classification and the techniques of gingival tissue management in case of mucogingival problems. the aim of this study is to evaluate the accuracy of different assessment methods of measuring gt and to classify into the different gingival phenotypes. periodontally clinically healthy patients will be recruited from the dental clinic complex (miu) according to eligibility criteria. the gingival tissue thickness will be measured using probe-colored periodontal probes (cpp), standard periodontal probes (spp) and transgingival sounding with an endodontic file (iso #20), visual judgment using photographs will be done to the three assessment methods. all readings including gt (1ry outcome) as well as keratinized tissue width and probing depth will be carried out by three calibrated outcome assessors. data collected will be tabulated and statistically analyzed.

Eligibility criteria:
inclusion criteria: * systemically free patients (american society of anesthesiologists (asa) i or ii) * patients having a state of clinical periodontal health * patients aged from 18 to 65 years old * both genders * presence of anterior teeth in mandible and maxilla. * good oral hygiene exclusion criteria: * carious teeth, teeth with crowns or veneers and non-carious cervical lesions * patients with healthy reduced periodontium. * smokers * pregnant and lactating females * patients taking drugs that affect the gingival tissues

Keywords: gingival thickness colored periodontal probe (cpp) standard periodontal probe (spp) trans gingival sounding
the effects of ripasudil in patients with fed undergoing femtosecond laser assisted cataract surgery

Conditions: Fuchs' Endothelial Dystrophy; Cataract

Summary: the purpose of this research is to investigate the effects of ripasudil administered as an ophthalmic solution in patients with fed after femtosecond laser assisted cataract surgery. the secondary aim is to identity the characteristics of patients who will benefit the most with the use of ripasudil based on the test results obtained from this study.

patients with fuch's corneal endothelial dystrophy and undergoing femtosecond laser-assisted cataract surgery will be recruited for this study. they will be randomly assigned into treatment or placebo group. the investigators hypothesize that the rock inhibitor ripasudil 0.4% helps maintain corneal endothelial functional integrity and reduce cell loss after cataract surgery in patients with fed. to test the hypothesis, the investigators plan to conduct a randomized clinical trial which aims to: 1. evaluate the clinical outcomes of fed eyes following flacs with and without ripasudil 0.4% 2. to identity which fed patients will most likely benefit from the use of ripasudil 0.4% based on pre-operative parameters 3. to monitor for any adverse effects in patients assigned to ripasudil 0.4%

Eligibility criteria:
inclusion criteria: 1. patients with fed who will be listed for cataract surgery as part of standard clinical practice (a cataract will be defined as clouding of the lens that interferes with normal vision). 2. only patients older than 50 years will be included, as cataracts develops with increasing age. no gender criteria are applied. 3. ability to provide informed consent, and are willing and able to sign a written informed consent form prior to any study-specific procedures. 4. patients must be willing and able to return for scheduled follow-up examinations for up to 12 months after the surgery. exclusion criteria: 1. patients who are unable to give consent. 2. an only-functioning eye in a patient who has lost visual potential in the contralateral eye. 3. diagnosis of clinically relevant eye diseases that may interfere with the aim of the study. 4. history of ripasudil use, as well as other systemic disease such as cardiovascular or renal disease. 5. patients who have previous allergic reactions to the contents present in glanatec ophthalmic solution 0.4%

Keywords: ripasudil
probiotics to treat "inflammatory depression"

Conditions: Depression

Summary: the main aims of this project are to test if: i) specific probiotic lactobacilli (added to stabilized ongoing treatment) are efficacious in treating depressive symptoms in individuals with low-grade inflammation, defined using high sensitivity c-reactive protein (hs-crp) and bmi. ii) this effect is mediated through decrease of inflammation, estimated by treatment-associated changes in blood and faeces biomarkers. secondary aims are to investigate the relationship between specific depressive symptoms and inflammation and if there is a correlation between certain pro-inflammatory or metabolic markers and depression.


Eligibility criteria:
inclusion criteria: 1. age, 18-85 2. depressive episode according to the dsm-v 3. madrs-m score \>18 4. all subjects will be stable on an antidepressant medication or in cognitive behavioural therapy (cbt) for \>4 weeks 5. subjects will be willing not to significantly alter their diet during the period of the study 6. a hs-crp value ≥1mg/l and bmi \>25 exclusion criteria: 1. serious or unstable medical illness that in the investigator's opinion could compromise response to treatment or interpretation of study results. 2. known or suspected allergy to the study compounds. 3. ongoing infection. 4. a diagnosis of psychotic disorder, bipolar disorder, personality disorder mental retardation, dementia, or individual whom, due to other causes, lack the ability to make an informed decision. 5. ongoing ect. 6. patients who, in the investigator's judgment, pose a current, serious suicidal. 7. a diagnosis for any substance use disorder (except nicotine or caffeine) in the 3 months prior to the screening visit. 8. any medications (within 1 week of baseline or during the trial) that might confound the biomarker findings, including: regular ingestion of nsaids or cox-2 inhibitors, or any use of oral steroids, immunosuppressants, interferon, chemotherapy (patients will be instructed not to take an nsaid, cox-2 inhibitor or aspirin in the 24 hours prior to a biomarker assessment visit). 9. antibiotic treatment/consumption within four (4) weeks before baseline visit. 10. patients who have taken foods or supplements with probiotics later than two (2) weeks before baseline visit. 11. active participation in other clinical studies with ongoing study visits. 12. pregnancy.

Keywords: inflammation
asthma clinics helping expand cost conversations

Conditions: Asthma in Children

Summary: healthcare costs are a critical barrier to u.s. families' ability to access the preventive care needed to manage their children's asthma. asthma specialty care teams are uniquely positioned to help families navigate these cost barriers, but lack structured approaches to discussing this sensitive and complex topic. this study will train asthma specialty care teams to identify families at risk for financial burden and engage in conversations about strategies to manage asthma care costs. the study team will evaluate the impact of a health care provider training on the frequency of cost navigation conversations. the investigators hypothesize that the health care provider training will increase the frequency of parent-reported cost conversations in the clinic.


Eligibility criteria:
inclusion criteria: eligible caregivers will: * attend a routine asthma care appointment for a 4-17 year old child * screen positive for possible financial burden related to the cost of asthma care eligible healthcare providers will: * be members of a pediatric asthma specialty care team exclusion criteria: caregivers will not be eligible if they: * attend an appointment for conditions other than routine asthma care * do not screen positive for possible financial burden related to the cost of asthma care healthcare providers will not be eligible if they: * are not part of the pediatric asthma specialty care team in the participating clinic

Keywords: cost of care patient provider communication financial burden
physical activiy intervention programm

Conditions: Physical Activity; Fitness; Overweight and Obesity

Summary: the purpose of this study is to evaluate the effectiveness of a recreational physical activity intervention for reducing the prevalence of overweight/obesity and other cardiovascular risk factors

a greater intensity of the intervention, and a longer weekly duration that extends until the weekend, could improve the efficiency in obesity.

Eligibility criteria:
inclusion criteria: * the parents of the children will be informed about the objectives and methods of the study, and will give their written consent to the participation of the children. similarly, the study will introduce children from classroom to class and their oral consent will be obtained exclusion criteria: * participating children will be free from serious learning difficulties, or physical or mental disorders, that could prevent participation in scheduled physical activities.