Kornimate/medical-research-clean huggingface dataset:
effects of virtual reality on dual task performance

Conditions: Stroke

Summary: this study evaluates the effects of virtual reality treatment in addition to robotic gait therapy on dual task performance, balance and gait in chronic stroke patients. half of participants will attend virtual reality treatment in addition to robotic gait therapy for 12 sessions, while the other half will attend only robotic gait therapy for 12 sessions.

following stroke, motor disorders, balance disorders, falls, gait disturbances and cognitive disorders are frequently seen. in stroke rehabilitation, with the use of robots and virtual reality systems with conventional methods, it is aimed to increase patient's motivation, to check if exercise is effective, to provide objective evaluation data and to support the motor learning process and the use of these methods in the field of neurological rehabilitation is increasing. multi-task evaluations can be made with the virtual environments created by virtual reality applications and complex tasks. the traditional approach to stroke rehabilitation is mainly focused on balance and gait training under single task conditions. in everyday life, people should not only have balance and mobility skills, but also have the ability to perform other cognitive and motor tasks with these skills. therefore, traditional approaches are not sufficient for the individual to return to society after a stroke. in this respect, this study was planned in order to examine the effects of frequently used virtual reality treatment in addition to robotic gait therapy on the dual task, balance and gait performance.

Eligibility criteria:
inclusion criteria: * volunteer to participate in the research * stroke for the first time * to be able to walk independently before the disease * to score 3 or above in the functional ambulation classification * 6 months after stroke diagnosis * not having open wounds * severity of spasticity of the lower extremities to be 3 and below according to the modified asworth scale * to score 24 or more in the mini mental state examination exclusion criteria: * acute internal problems, additional neurological diseases, or orthopedic problems that might limit walking * to have received botulinum toxin treatment during 6 months before treatment or during treatment * to have stroke on both sides * to have neglect

Keywords: virtual reality stroke dual task
the use of home oral glucose tolerance test kit in screening cystic fibrosis related diabetes

Conditions: Cystic Fibrosis Related Diabetes; Cystic Fibrosis

Summary: the aim of this study is to establish if the self-administered electronic oral glucose tolerance test kit can increase the annual uptake of screening for cfrd in children who are between 10 and 17 years of age with cf.

cystic fibrosis related diabetes (cfrd) is the most common secondary complication of cystic fibrosis. it affects nearly 20% of adolescents and 40-50% of adults. undiagnosed cfrd is associated with significant decline in lung function and nutritional status with an increase in mortality. this emphasises the importance of screening for cfrd in children with cf to minimise the nutritional and pulmonary consequences of diabetes. the uk cf trust guidelines, the european consensus statement and us cystic fibrosis foundation clinical care guidelines recommend the 2hr (1.75g/kg) oral glucose tolerance test as a screening tool on an annual basis in all cf patients without cfrd. the american diabetes association (a.d.a) recommends that annual screening for cfrd should begin by age 10 years in all cf patients who do not have cfrd. the european consensus statement on this is in agreement for screening to start at age 10 years. this standard is often applied within the united kingdom. the current gold standard screening tool, the oral glucose tolerance test, is resource intensive. this requires an individual/child and a parent to attend a clinical facility while fasted and requires trained health care professionals to take venous samples, analyse and interpret the results. there are also problems encountered in standardising the test. the patient should be fasted and must travel to clinic for the test in the morning. the ogtt, if done at hospital, can therefore affect an individual's time off work, time off school, can cause inconvenience and expensive for an individual, parent and child to travel to clinic. the unpredictability of workload for hospital staff means that test times are often not strictly adhered to or accurately recorded. in patients with cystic fibrosis there is also an additional risk of cross infection when they attend the hospital for ogtt. these factors limit the uptake of ogtts for screening in children with cystic fibrosis. to overcome these issues a simple, disposable, self-administered electronic ogtt kit containing everything required to perform the ogtt at home with simple written and pictorial instructions has been used in this study. the aim of this study is to establish if the self-administered electronic oral glucose tolerance test kit can increase the annual uptake of screening for cfrd in children who are between 10 and 17 years of age with cf.

Eligibility criteria:
inclusion criteria: * children diagnosed with cystic fibrosis who are between 10 years and 17years old and managed at great ormond street hospital. exclusion criteria: * children who are diagnosed with cystic fibrosis related diabetes.
the real-world clinical study of azvudine tablets in the treatment of covid-19

Conditions: COVID-19; Azvudine

Summary: to establish a real-world clinical cohort and database of azvudine in the treatment of sars-cov-2 infection, and to provide stable and reliable evidence for the clinical efficacy and safety evaluation of azvudine in the treatment of sars-cov-2 infection.


Eligibility criteria:
inclusion criteria: 1. age above 18 years old (including the cut-off value), regardless of gender; 2. patients diagnosed with 2019-ncov infection according to the diagnostic criteria of the latest edition of the diagnosis and treatment plan for 2019-ncov pneumonia issued by the health commission of china; 3. informed consent has been signed. exclusion criteria: 1. known or suspected allergic to the components of azivudine tablets; 2. patients with severe liver, kidney, heart and other organ damage; 3. pregnant or lactating women who planned to give birth during or within 6 months after the trial; 4. had participated in other clinical trials or were using investigational drugs within 12 weeks before medication;
usefulness of exhaled breath condensate for evaluation of markers of airway inflammation in children with asthma

Conditions: Asthma

Summary: exhaled breath condensate (ebc) has emerged as a novel noninvasive technique for assessment of airway inflammation, and it provides information on airway lining fluid composition. traditionally, such assessment relies on invasive diagnostic tools such as bronchial biopsy and bronchoalveolar lavage (bal) to obtain specimens from the airway but it is very uncomfortable procedure especially for young patients. the aim of this study is to evaluate the effect of allergic disease, disease monitoring and exposure to tobacco smoke on airway inflammation measured by markers in exhaled breath condensate (ebc) in children with asthma allergic to house dust mite. also, we aim to assess correlations between cytokine concentrations in ebc and clinical characteristic of the patients with exercise-induced bronchoconstriction as another phenotype of asthma.

markers that can be identified in the ebc of patients with asthma include ph, hydrogen peroxide, nitrogen oxides, eicosanoids, isoprostanes, adenosine, certain cytokines, chemokines, and growth factors. concentrations of these biomarkers are influenced by inflammation, oxidative stress, and can be modulated by therapeutic interventions. there is evidence that some markers in ebc differ between patients with asthma and controls, and some of them can correlate with asthma severity score, lung function. the aim of this study is to evaluate the effect of allergic disease, disease monitoring and exposure to tobacco smoke on airway inflammation measured by markers in exhaled breath condensate (ebc) in children with asthma allergic to house dust mite. we will also evaluate the effect of antiasthmatic treatment applied out of dust season on the number of exacerbations in "asthma epidemic" in september. we will evaluate the effect of exposure to tobacco smoke on antiasthmatic treatment. also, we aim to assess correlations between cytokine concentrations in ebc and clinical characteristic of the patients with exercise-induced bronchoconstriction (eib) as another phenotype of asthma. at the first study vist patients with eib underwent fractional exhaled nitric oxide measurement (feno) and baseline spirometry, performed exercise treadmill challenge (etc) and ebc samples were obtained at the end of etc.

Eligibility criteria:
inclusion criteria: * children with mild to moderate asthma allergic to house dust mite exposed/nonexposed to tobacco smoke * healthy children exclusion criteria: * sensitization to allergens other than house dust mites * other chronic diseases * asthma exacerbation * pregnancy * oral corticosteroids for 4 weeks before the study * montelukast sodium for 2 weeks before the study

Keywords: asthma children ebc exposure to tabacco antiasthma treatment
social history and glaucoma progression

Conditions: Glaucoma Open-Angle

Summary: the objective of this study is to predict of glaucoma progression. by imaging of the retinal nerve fiber layer rnfl, optic nerve head (onh) and macular measurements using spectral-domain oct (sd-oct) instruments

glaucoma is a multifactorial optic neuropathy characterized by structural damage of retinal ganglion cells (rgcs) and their axons that is associated with vision loss and may lead to irreversible blindness. because glaucomatous damage is irreversible and effective treatment is available to halt further damage, glaucoma management should be optimized with precise micrometer-scale quantifications of ocular structures that improve detection of the disease and its progression. the introduction of oct technology more than 20 years ago provided in vivo detailed visualization of the optic nerve head (onh) and retina and enabled the quantitative evaluation of these tructures. circumpapillary retinal nerve fiber layer (rnfl) thickness is a common oct measurement that provides comprehensive evaluation of all rgcs in an eye as they converge into the onh. when measured with spectral-domain oct, the rnfl has been shown to differentiate between healthy and glaucomatous eyes. the steady evolution of oct technology has led to imaging with better resolution, higher scanning speeds, and advanced imaging patterns that has improved the reliability of oct measurements and allowed for detection of minute changes that can improve the sensitivity of progression detection. assessment of glaucoma progression usually is based on event or trend analysis. event-based progression determines when a measurement exceeds a pre-established threshold for change from baseline. trend-based analysis quantifies the rate of a parameter's progression over time.

Eligibility criteria:
inclusion criteria: * iop measurements more than 21 mmhg * open angle on gonioscopy (grade 3 or 4 on schaffer grading system for angle width) * glaucomatous visual field defects consistent with glaucomatous optic disc changes. * eyes with baseline macular and onh oct images and onh photograps exclusion criteria: * participants with significant retinal disease. * non-glaucomatous optic neuropathy. * anomalous discs * any retinal pathology. * history of cataract or glaucoma surgery will not be exclusion criteria.

Keywords: glaucoma oct
notes-assisted laparoscopic cholecystectomy surgery

Conditions: Cholelithiasis; Cholecystitis

Summary: this study proposes to evaluate the ability to reduce the size and number of laparoscopic incisions required to perform gall bladder removal by using flexible endoscopic instruments introduced through the mouth, into the stomach and through the stomach wall.

a typical laparoscopic gall bladder removal procedure requires placement of a rigid laparoscope through a 1.5-2.5 cm incision in the umbilicus and then 2-3 additional 0.5 cm incisions for additional instrumentation. while post-operative complication rates for this procedure are small, wound infection, particularly of the large incision, is one of the most common post-operative complications. there is also a risk of a post-operative hernia at these incision sites. a less invasive surgical technique that reduces the size or number of laparoscopic incisions offers the potential clinical benefits of eliminating wound infections, hernias and decreasing post-operative pain following laparoscopic gall bladder removal.

Eligibility criteria:
inclusion criteria: * ability to undergo general anesthesia * age \>= 18 yrs. of age and \<= 85 yrs. of age * ability to give informed consent exclusion criteria: * acute cholecystitis * bmi \>= 40 * contraindicated for egd * presence of common duct stones * presence of esophageal stricture * altered gastric anatomy

Keywords: cholecystectomy notes transgastric
comprehensive lifestyle improvement program for men with prostate cancer2 (clipp2)

Conditions: Prostate Cancer

Summary: this study is an investigator initiated clinical study. a prospective, single arm unblinded, open label study will be carried out to determine the feasibility of recruitment, retention and adherence of 36 prostate cancer survivors who have been on androgen deprivation therapy within the last 5 years for a lifestyle modification intervention.

introduction: androgen deprivation therapy (adt) has been demonstrated to improve disease free and over-all survival in men with prostate cancer (pca). adt for pca is associated with adverse cardio-metabolic effects such as reduced libido, hot flashes, metabolic syndrome, diabetes, myocardial infarction and stroke. this reduces quality of life (qol) and potentially affects mortality. there is paucity of data regarding comprehensive lifestyle interventions in men on adt for pca. existing studies used non-standardized interventions or lack data on metabolic risk factors. clipp is designed to address these gaps by using an intervention modelled after the diabetes prevention program (dpp) with an emphasis on low carbohydrate and a keto diet, a standardized multi-component intervention with demonstrated effectiveness in reducing diabetes risk factors that has been successfully adapted for multiple disease types including breast cancer. intervention: * 24 weeks * health coaching weekly * serum \& urine baseline, week 12 and week 24 * anthropometric measures * questionnaires * bmi measurements

Eligibility criteria:
inclusion criteria: * diagnosed with prostate cancer stage i, ii or iii * on androgen deprivation therapy with last 5 years * willing to participate in a lifestyle modification program * willing to modify diet and eating practices * willing to participate in blood collection, urine collection and measurements * minimum of 30 days since participating in another study/trial * english speaking * 40 to 80 years of age * bmi \>25% exclusion criteria: * currently participating in another study or trial * currently in hospice * inability to walk two city blocks * inability to comprehend informed consent or procedural requirements * digestive diseases (ibd, diverticulitis, etc) that might prevent him from increasing fruit and vegetable intake * subjects already following an intensive lifestyle modification plan * bmi \<25%

Keywords: low carbohydrate ketogenic androgen deprivation therapy
impact2: monitoring interventions to improve artemisinin-based combination therapy (act) access and targeting

Conditions: Malaria; Anaemia

Summary: it is generally agreed that artemisinin-based combination therapy (act) is the malaria therapy of choice but there is much less agreement about the best act-deployment strategies. countries are now beginning to adopt policies to enhance act deployment that aim to address 2 key goals: (i) making acts more readily and speedily accessible to patients: or (ii) targeting acts to patients shown to have malaria parasitaemia. the tanzanian government has secured funding to address both act access and targeting on a national scale. access is to be improved through the distribution of subsidised acts through private facilities and retail drug shops under the affordable medicines facility-malaria (amfm). targeting is to be addressed through enhancing microscopy and introducing rapid diagnostic tests (rdts) in health facilities at every level of the system. this study will evaluate these two interventions in 3 rural regions of tanzania which are all expected to receive both interventions during the study period. the investigators will assess the effectiveness of the interventions in terms of coverage, equity, quality, adherence, and public health impact using a pre-post plausibility design based on before and after household, health facility and outlet surveys. the null hypothesis is that the interventions will have no impact on the coverage of prompt effective treatment for fever and malarial. in addition, the investigators will estimate the cost and cost-effectiveness of implementation from a health system and household perspective. finally the investigators will explore the socio-cultural context and other factors that influence the implementation and outcome of the interventions.


Eligibility criteria:
inclusion criteria: * household survey - all consenting and assenting residents available in selected households * health facility survey - patients presenting to selected health facilities with fever or history of fever in the prior 24 hours; age \>= 3 months, or weight ≥ 5 kg; first visit to this health facility for this illness episode exclusion criteria: * household survey - children less than 3 months of age will be excluded from providing a blood sample * health facility survey - signs of severe illness

Keywords: antimalarials diagnosis access to treatment quality of care
immunologic biomarker profile of cerebrospinal fluid

Conditions: Multiple Sclerosis; Neuromyelitis Optica

Summary: the aim of this study was the describe the immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients


Eligibility criteria:
inclusion criteria: * patients who have had neuromyelitis ptica with anti-aqp4 antibodies, or anti- myelin oligodendrocyte glycoprotein antibodies, or double seronegative antibodies. * neuromyelitis optica patients have been prospectively included in the ofsep collection * multiple sclerosis patients, isolated myelitis or optic neuritis patients, and symptomatic controls whose samples will come from the "neuro" collection of the hospital biological collections center, * patients have given their free consent for use of their samples in research
preoperative decolonization and surgical site infections - a prospective randomized trial

Conditions: Orthopedic Disorders; Surgical Site Infection

Summary: surgical site infections are a major postoperative complication and are mostly due to colonization with endogenous germs, like staphylococcus aureus, staphylococcus epidermidis or propionibacterium acnes. in literature, preoperative decolonization procedures showed a trend in lowering surgical site infection rates, but especially in orthopedic surgery data is controversial and randomized controlled trials are lacking. in the main study, the study investigators aim at performing a controlled prospective randomized interventional trial to measure the impact of preoperative decolonization of nasal staphylococcus aureus carriers on surgical site infection rates in orthopedic surgery. in an alongside study a controlled prospective randomized interventional trial to measure the impact of preoperative skin decolonization of patients undergoing an orthopedic procedure will be conducted.

all participants will be assessed for eligibility during preoperative othopedic consultation. 2-3 weeks prior operation date participants will be screened for staph. aureus carriage by nose-swab. according to nose-swab results randomizaton and allocation to study arm will be performed. after one and three months post-operatively participants will be asked by phone interview if surgical site infections occured. results have to be confirmed by orthopedic surgeon if possible.

Eligibility criteria:
inclusion criteria: * patient older than 16 years * patient undergoing elective orthopedic procedure at the sonnenhof hospital * decolozination protocol can be performed timely * signed informed consent exclusion criteria: * no orthopedic surgery planned * allergy to mupirocin or chlorhexidine * presence of a nasal foreign body * no informed consent * pregnancy * decolozination protocol can't be followed timely * patients undergoing treatment/surgery for a documented infection

Keywords: orthopedic surgery surgical site infection decolonization staphylococcus aureus
effects of fatty acid supplementation on substance dependent individuals

Conditions: Substance-related Disorders

Summary: many substance dependent individuals continue to abuse a variety of substances during treatment for their disorder. often, substance dependent individuals are co-diagnosed with depression and violence problems. supplements of n-3 polyunsaturated fatty acids (pufas) may play a role in treating individuals with such substance abuse problems. the purpose of this study is to evaluate the effectiveness of the n-3 pufas eicosapentaenoic acid (epa) and docosapentaenoic acid (dpa) in treating relapse, aggression, and depression in substance dependent individuals.

past research suggests that low levels of some pufas play a role in the pathophysiology of depressive and aggressive disorders. in addition, there is also evidence that pufas play a role in treating substance dependent individuals. the purpose of this study is to determine the efficacy of efa and dpa in treating substance dependent individuals. participants will be randomly assigned to receive either 3 grams of n-3 pufas or placebo. treatment will last 3 months, followed by an observation period of 3 months. study visits will occur monthly and will last approximately one hour. study visits will include blood tests and a physical exam. throughout the study, participants will continue to receive standard substance abuse treatment and will complete urine tests at regular intervals.

Eligibility criteria:
inclusion criteria: * current or history of drug or alcohol dependence * used substances of abuse during the 3 months prior to study entry * enrolled in one of the va new york harbor healthcare system brooklyn campus substance abuse clinics exclusion criteria: * current or history of hallucinations, delusions, or memory problems * major physical illness (e.g., cardiovascular, pulmonary, gastrointestinal, renal, neuromuscular, or endocrine disorder) * liver function test greater than one standard deviation above upper normal limit * allergic to fish

Keywords: substance abuse depression aggression