Kornimate/medical-research-clean huggingface dataset:
physical therapy for men undergoing prostatectomy

Conditions: Prostate Cancer; Urinary Incontinence; Pelvic Floor Physical Therapy

Summary: the purpose of this study is to determine if pelvic floor muscle training with a physical therapist before and after surgery will improve health-related quality of life following robot-assisted radical prostatectomy.

goals of the present study will be to determine whether initiating pelvic floor muscle training preoperatively improves quality of life symptoms related specifically to urinary health following robot-assisted radical prostatectomy. drawing definitive conclusions from past studies is challenging secondary to various inconsistencies including: variability of physical therapy intervention, poorly defined definitions of continence, as well as poorly defined quality of life measurements. additionally, the vast majority of studies combined open and robotic prostatectomy increasing cohort heterogeneity and further blurring interpretation of results. the investigators' study will focus exclusively on patients undergoing robot-assisted radical prostatectomy. standardized pelvic floor muscle therapy as well as clearly defined patient outcomes (ie: validated questionnaires) will be utilized to determine whether preoperative initiation of formal pelvic floor physical therapy can improve health-related quality of life following surgery. in the era of robot-assisted radical prostatectomy does physical therapist initiated preoperative pelvic floor muscle training lessen the expected postoperative drop off in urinary related quality of life and/or improve patient's recovery of continence following surgery?

Eligibility criteria:
inclusion criteria: * patients scheduling to undergo robot-assisted radical prostatectomy * patients willing and able to complete the epic questionnaire in its entirety * ability to provide informed consent exclusion criteria: * previous prostate surgery * radiation treatment * history of incontinence defined as any pad use for urinary leakage in the past 6 months
gastrocnemius tightness and foot pain in children

Conditions: Child Development; Gastrocnemius Equinus

Summary: foot and leg pain among otherwise healthy children is a common reason for referral to our pediatric orthopaedics outpatient clinic. the pain is often intermittent and transient, but for some the pain is more dominating and has an impact on the child and families. children grown and have normal anatomical variations such as in-toeing, out-toeing, hypermobility, flatfeet, knock knees etc. assessing such normal variants is a major part of pediatric orthopaedic practice, and a common finding is a positive silvferskiöld test, indicating gastrocnemius tightness. this is when dorsiflexion of the ankle is limited with extended knee, compared to flexed knee. we do not know if this is a more frequent finding among children with foot and leg pain. there is however evidence that adults with painful foot conditions often have gastrocnemius tightness. this project will investigate for gastrocnemius tightness in otherwise healthy children referred to our pediatric orthopaedic outpatient clinic with foot and leg pain, and compare results with a similar control group of children without pain. the aim is to investigate if there is an association, and how pain and tightness develops over time. the knowledge from this project will enable us to develop new treatment strategies to this patient group, where current evidence based recommendations are few.


Eligibility criteria:
inclusion criteria: * otherwise healthy children referred to pediatric orthopaedic outpatient clinic with foot and/or leg pain with a normal leg function exclusion criteria: * patients with foot conditions, general medical conditions affecting the foot or clinical findings indicating a need for further investigation for a diagnosis. such as: foot deformities (cavo-varus foot, clubfoot) tarsal coalitions neuro-orthopedic conditions (cp, mmc) fracture sequelae infections and tumour
contrast-enhanced mammography in women with a personal history of breast cancer and dense breast tissue: benefit?

Conditions: Breast Cancer

Summary: this study aims to assess the effectiveness of contrast-enhanced mammography (cem)as an alternative to traditional ultrasound for breast cancer screening in women with dense breasts and a personal history of breast cancer. cem combines standard mammography with a contrast agent to better detect tumors, particularly in women with dense tissue where traditional mammograms may miss signs of cancer. the study will compare cem with ultrasound and mri to determine its accuracy in detecting cancer, reduce wait times for screening, and provide a more affordable option than mri. women who participate will have their screening done in one visit, improving convenience and access. the study will track cancer detection rates, biopsy results, and patient satisfaction over two years to evaluate the benefits of cem for early breast cancer detection.

primary outcome measure: 1. detection rate of breast cancer the primary outcome measure is the detection rate of breast cancer in women with dense breast tissue using contrast-enhanced mammography (cem). the sensitivity, specificity, and overall accuracy of cem in detecting malignancies will be compared to conventional mammography and ultrasound.

Eligibility criteria:
inclusion criteria: * women presenting at rose ages breast health center, who are currently waiting for supplemental screening ultrasound, according to pre-established guidelines at toh for supplemental screening. * women ages 50-69 years of age * those willing to participate in the study, sign an informed consent and undergo iv iodinated contrast injection * women with dense breasts (category c or d) and normal mammograms (bi-rads 1 or 2) * no evidence of renal disease exclusion criteria: * patients with renal insufficiency (reduced egfr \<20ml/min) * previous allergic reactions to iodine-based contrast. * prior contrast allergy (ct contrast) * thyroid disease

Keywords: mammography screening contrast-enhanced mammography dense breasts
energy dispersive bracing for conservative treatment of knee osteoarthritis

Conditions: Knee Osteoarthritis; Arthritis

Summary: the goal of this study is to explore the effectiveness of a commercially available, over-the-counter knee brace in the conservative treatment of knee osteoarthritis. participants will either be fitted with a brace and told to wear it every day during normal activities, fitted with the brace and given instructions on a set of quadriceps strengthening exercises to complete twice daily, every day, or be given the exercise instructions, but not fitted with a brace. functional and subjective outcomes will be collected preoperatively and at 6 and 12 weeks from baseline, with the goal of informing the effectiveness of bracing alone versus a home exercise program, and whether the combination of those provides the most therapeutic benefit to participants.


Eligibility criteria:
inclusion criteria: * subject is being treated for knee joint pain * subject is willing and able to comply with the evaluation schedule exclusion criteria: * subject is undergoing surgery during the follow-up window that would limit their ability to comply with the evaluation schedule and/or significantly affect the outcomes measures * subject has current alcohol, opioid, or other drug dependence * subject is taking prescribed medication for pain other than in the knee joint (e.g. back pain)
systematic machine learning algorithm for rapid thrombosis detection

Conditions: Deep Vein Thrombosis

Summary: the goal of this clinical trial is to compare the use of a machine learning-based algorithm and point-of-care d-dimer to laboratory d-dimer and compression ultrasound to exclude deep vein thrombosis in the under extremities in patients referred to a medical department suspected of having deep vein thrombosis. the main aim is to answer are if a machine learning algorithm and point of care d-dimer can exclude deep vein thrombosis in more patients than clinical assessment and d-dimer alone.

all participants will follow the usual diagnostic algorithm used for patients with suspected dvt referred to ostfold hospital (all patients are examined by a physician, d-dimer is analyzed in all patients, ultrasound is performed by a radiologist in patients with positive d-dimer). in addition to usual care, poc d-dimer, poc ultrasound (performed by ed physicians), blood sampling for biobanking, and photographies of the under extremities will be performed. the machine learning model will be tested to see if the prediction is correct. in participants where ultrasound is performed, it will also be assessed whether the machine learning algorithm could have excluded the participant without the use of ultrasound. none of the additional procedures will have any impact on the patient diagnostics or treatment.

Eligibility criteria:
inclusion criteria: * patients referred to the ed due to suspicion of dvt * age ≥ 18 years * able to give informed consent exclusion criteria: * ongoing use of anticoagulation for more than 72 hours * previous participation in the study * life expectancy of less than three months.

Keywords: machine learning poc d-dimer poc ultrasound
the effects of safe early intervention approach in premature infants in turkey

Conditions: Infant, Premature, Diseases

Summary: in this study, it was aimed to develop the safe treatment approach, which is a family collaborative early intervention approach based on sensory strategies, activity-based motor training and environmental enrichment, and to examine the effects of this approach on sensory, motor, cognitive and language development in premature infants.

early intervention practices in turkey is widely based on the principle of neuro-developmental therapy (ndt). it has been reported in recent years that the ndt approach has minimal effect on the development of risky premature infants. for these reasons, it was necessary to develop an early intervention program that does not include passive interventions and includes sensory and motor strategies in our country. within the scope of this study, a new early intervention approach that can be applied to infants between 0-24 months has been developed based on the shortcomings in the literature. sensory strategies, activity-based motor training, family collaboration and environmental enrichment constitute the basic principles of this early intervention program. the name of the early intervention program was formed from the english initials of these basic principles and was determined as safe early intervention approach (s: sensory strategies, a: activity based motor training, f: family collaboration, e: environmental enrichment). in this study, it was planned to establish the theoretical and practical foundations of the safe early intervention approach developed by the gazi university, faculty of health sciences, department of physiotherapy and rehabilitation. also we aimed to examine the effects of this approach on sensory, motor, cognitive and language development in preterm infants with corrected ages of 9-10 months.

Eligibility criteria:
inclusion criteria: * being born before 37 weeks * a history of neonatal intensive care unit (nicu) for 15 days or more * adjusted age to be between 9-10 months * family's willingness to participate in the study exclusion criteria: * having a congenital anomaly or systemic disease * having a high risk for the diagnosis of cerebral palsy (intraventriculer hemorrhage (ivh) stage 4 or periventricular leukomalacia (pvl) stage 3-4, such as the absence of fidgety movements).
observatory of patients with chronic lymphocytic leukemia / lymphocytic lymphoma or waldenstrom disease infected with covid-19

Conditions: Chronic Lymphocytic Leukemia, Lymphocytic Lymphoma or Waldenstrom Disease

Summary: the covid-19 epidemic (coronavirus disease 2019) which is currently raging in france is an emerging infectious disease linked to a virus of the genus coronavirus (sars-cov-2). the first cases were reported in wuhan, china, in late december 2019 \[1\]. globally, it has been placed in the "pandemic" stage by the who since march 11, 2020. coronavirus viruses have been responsible for epidemics in the past such as the sars epidemic in 2002 (syndrome severe acute respiratory) linked to the sars-cov virus, or the epidemic of mers (middle east respiratory syndrome) that affected the middle east in 2012. patients with chronic lymphocytic leukemia (cll) / lymphocytic lymphoma or waldenstrom disease (wd) therefore represent a population at high risk of developing a severe form in the event of covid-19 infection. to date, no data is available in the literature to assess the impact of the covid-19 epidemic in this population of patients with cll / lymphocytic lymphoma or wd.


Eligibility criteria:
inclusion criteria: * diagnosis of chronic lymphocytic leukemia / lymphocytic lymphoma or waldenstrom disease according to the criteria of the who 2016 with a proven or probable infection by covid-19 according to the following criteria: * proven infection: pcr positive regardless of the radio-clinical picture (other tests made available later and having good diagnostic performance will be accepted) * probable infection: the diagnosis of probable infection is retained in case of negative pcr or not made if presence of at least 2 major criteria or of a major criterion associated with at least 2 minor criteria among the following, in the absence other documented cause. * major criteria: * fever * loss of smell / taste * at least one respiratory sign among cough, dyspnea, chest pain * radiological signs suggestive of the scanner (areas or diffuse appearance of frosted glass, condensations including pseudonodular condensations, association of frosted glass and condensation within the same lesion, nodules and micronodules, thickening of the interlobular septa) or on an x-ray of the thorax ( interstitial, alveolo-interstitial or alveolar syndrome, unilateral or bilateral) * notion of storytelling with a person whose sars-cov-2 infection has been formally documented * minor criteria * aches * sore throat * rhinorrhea * headache * diarrhea * abdominal pain * frank asthenia * conjunctivitis exclusion criteria: * patient opposition
decitabine and anti-pd-1 in r/r dlbcl

Conditions: Diffuse Large B Cell Lymphoma; Relapse/Recurrence; Extranodal Extension; Central Nervous System Lymphoma

Summary: patients with relapsed/refractory diffuse large b cell lymphoma with extranodal (esp. central nervous system) involvement treated with low-dose decitabine plus anti-pd-1 regimen. 3 weeks for a cycle, with a total of 2 years or until the disease progress esor unacceptable toxicity occurs, or the patient decides to withdraw from the trial.

to evaluate the effectiveness and safety of patients with relapsed/refractory diffuse large b cell lymphoma with extranodal (esp. central nervous system) involvement treated with low-dose decitabine plus anti-pd-1 regimen. 3 weeks for a cycle, with a total of 2 years or until the disease progress esor unacceptable toxicity occurs, or the patient decides to withdraw from the trial. enrollment was planned to be completed within 2 years, and all trials were followed up for 12 months after the last enrolled patient completed treatment. all cases will be followed up and the long-term curative effect will be observed and recorded.

Eligibility criteria:
inclusion criteria: * 14-80 years old, male or female; * pathologically confirmed relapsed/refractory diffuse large b cell lymphoma with extranodal (central nervous system) involvement; * expected survival of more than 3 months; * ast and alt ≤ 3.0 uln; tbil and ccr ≤ 1.0 uln; * inactive infection and severe mental illness * ecog score 0\~2 * according to the new york heart association (nyha) cardiac function grading standards, the heart function grading should be grade i or grade ii; cardiac ejection fraction \>50% or not lower than the lower limit of the range of laboratory test values at the study center; no pathological abnormality was found in ecg; there was no clinically significant pericardial effusion or pleural effusion * the serum pregnancy test of female subjects must be negative * signed informed consent exclusion criteria: * subjects with any autoimmune disease requiring long-term use of corticosteroids or immunosuppressive drugs or with a history of other tumors; * severe uncontrolled medical disease or active infection (including hiv+); * active gastrointestinal bleeding or 1 month history of gastrointestinal bleeding; * received allogeneic hematopoietic stem cell transplantation within 6 months or are participating in other clinical studies; * pregnant or nursing women; * subjects who must be forcibly detained for the treatment of mental or physical diseases (e.g. infectious diseases); * the researcher thinks it is not suitable for this clinical study (such as poor compliance, drug abuse, etc.) * the situation that the researcher judged was not suitable for inclusion
the effect of lipid emulsions on free fatty acids and free bilirubin in premature newborns

Conditions: Prematurity

Summary: the goal of this research study is to compare the levels of free fatty acids and free bilirubin between two intravenous lipid emulsion products in premature newborns.


Eligibility criteria:
inclusion criteria: * premature newborns (\ 28 weeks) \<8 days of age * receiving lipid infusions \<1 g/kg/day at enrollment * anticipated to be treated with 3 g/kg/day for a minimum of 48 hours. exclusion criteria: * patients with direct hyperbilirubinemia \>1.5 mg/dl * with suspected sepsis meeting systemic inflammatory response syndrome (sirs) criteria * undergoing treatment with a continuous infusion of morphine * with a continuous infusion of pressors (dopamine, dobutamine, epinephrine, etc.) * positive blood cultures

Keywords: parenteral nutrition lipid emulsion free bilirubin free fatty acids
impact of dietary intervention on children of adhd at sohag university hospital

Conditions: Attention Deficit Hyperactivity Disorder

Summary: attention-deficit hyperactivity disorder (adhd) is a neurodevelopmental disorder of persistent impairment of attention, hyperactivity, and impulsivity which worsens daily functioning and quality of life , including social troubles , poor academic achievement and occupational problems .it is one of the most common psychiatric disorders between children . the prevalence of adhd was 7.2% all over the world in 2015 and this percentage is increasing every year . in arab countries, a systematic review of studies reported that the prevalence of adhd ranged from 1.3% to 16%. . adhd has been treated with medical treatment such as psychostimulants (methylphenidate and amphetamines), noradrenergic treatment as atomoxetine and alpha-2a-adrenergic agonists as guanfacine and clonidine , behavioral treatment and their combination . due to adverse effects of medical treatments and behavioral therapy limitations, other approaches to augment multimodal adhd management has been tested . non medical treatment as digital therapeutics may improve cognitive functions and attention in adhd . physical activity interventions for adhd may improve cognitive , physical and psychological functions.


Eligibility criteria:
inclusion criteria: * 6-12 years children with adhd exclusion criteria: * patient with eating disorders. * patients with chronic medical illness. * patients with iq below 70. * patients who would drop out from the study 1. if patient would be absent for 3 months, 2. if patient would fail for any reason to continue his dietary restriction.
clinical characteristics, treatments, and outcomes of mi patients presenting with normal ecg

Conditions: Non-ST Elevated Myocardial Infarction; Electrocardiography

Summary: the investigators aimed to analyzed data for hospitalized mi patients with normal ecg.

the electrocardiogram (ecg) at presentation is a useful tool for risk prediction. patients with acs（acute coronary syndromes） and st-segment depression on ecg have a worse prognosis than patients with a normal ecg. st-segment depression is not only a qualitative marker, but also a quantitative marker of risk, because the number of leads with st-segment depression and the magnitude of st-segment depression (either within a single lead or as sum over all leads) are indicative of the extent of ischaemia and correlate with prognosis.the presence of st-segment depression \>1 mm in \>_6 leads in conjunction with st-segment elevation in avr and/or v1, particularly if the patient presents with haemodynamic compromise, suggests multivessel ischaemia or severe left main coronary artery stenosis. however,in patients presenting without persistent st-segment elevation,the clinical features, treatments, and outcomes in patients with normal ecg is still unclear.

Eligibility criteria:
inclusion criteria:all patients hospitalized with a principal diagnosis of non-st-segment elevation infarction (nstemi) according to the current acc/aha guidelines. exclusion criteria: end-stage organic disease, thrombotic hematological disorders, and poor echogenicity

Keywords: clinical characteristics treatments outcomes normal ecg
finding atrial fibrillation in patients with unexplained stroke using longterm cardiac monitoring

Conditions: Stroke

Summary: the surprise study investigates atrial fibrillation(afib) in patients with a previous unexplained stroke. it uses long term monitoring of the heart of up to three years, searching for paroxysmal atrial fibrillation(paf) otherwise undetected in this population.

the surprise study investigates the patients with cryptogenic stroke or transient ischemic attack (tia), monitoring them with a cardiac loop recorder for up to three years. it aims at estimating the amount of paroxysmal atrial fibrillation within our population of cryptogenic stroke patients. standard workup for a stroke patient does offer cardiac evaluation, but monitoring is limited to the time admitted, often just a few days.

Eligibility criteria:
inclusion criteria: * computerized tomography (ct) or magnetic resonance imaging (mri) verified cryptogenic stroke or tia; * \> 18 years of age, * the ability to provide a written consent exclusion criteria: * prior or known afib * af found during work up including 24 hour telemetric monitoring.

Keywords: cryptogenic stroke atrial fibrillation longterm monitoring loop recorder
efficacy and safety of inhaled insulin compared with subcutaneous human insulin therapy in adults with type 1 diabetes

Conditions: Diabetes Mellitus, Type 1

Summary: this study is being done to find out the good and bad effects of a drug that is not approved for sale and the effects if any on measures of pulmonary function in adult males and females with type 1 diabetes mellitus. the drug is called exubera (inhaled insulin). this study included a 2-year comparative treatment period followed by a 6-month follow-up period during which inhaled insulin-treated subjects were switched back to subcutaneous short-acting insulin. after this follow-up period, all eligible subjects entered a comparative extension period that was to last for 5 years. when the comparative portion of the study was terminated, all subjects were requested to return for a final extension follow-up month 3 visit.

pfizer announced in october 2007 that it would stop marketing exubera. nektar, the company from which pfizer licensed exubera, announced on april 9, 2008 that it had stopped its search for a new marketing partner. accordingly, there will be no commercial availability of exubera. as a result, study a2171022 was terminated on june 9, 2008. neither safety nor efficacy reasons were the cause of the study termination.

Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus exclusion criteria: * severe asthma or copd * smoking * brittle diabetes