Kornimate/medical-research-clean huggingface dataset:
a study for the assessment of the words used by patients and physicians to express the symptoms of chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is characterized by a progressive decline in lung function and increased symptoms such as breathlessness/dyspnoea, cough and expectoration. even though subjective in nature, the symptomatology of copd and mainly that of breathlessness/dyspnoea has been studied with the use of objective measurement tools. taking into consideration that the symptoms experienced by the patient who suffers from a progressive disease such as copd can only be perceived and interpreted by the patient him- or herself, and thus difficult to be quantified, copd remains a challenge in clinical research. therefore, there is a need to carry out qualitative studies that will provide insight into the wide spectrum of copd symptomatology from the patient's perspective. in addition, a further mapping of the impact that copd symptoms' perception has on a patient's life is required, as well as of the different pathways through which symptoms' perception is interpreted regarding the limitations of daily living activities, and the subsequent impact on disease management. the more the physician learns on the embodied experience of copd, the better he/she may assist the patient in achieving optimal copd management. thus this cross-sectional observational study was designed aiming to obtain these data. specifically, the study aims to evaluate the most frequently used words by the patients and the physicians to express the symptoms of copd as well as the limitation of activities that it causes.


Eligibility criteria:
inclusion criteria: * aged 45-75 years * current or former smokers * known history of copd for at least 6 months before enrolment into the study documented by spirometry (fev1 /fvc \<70%) * patients with stable copd (no exacerbation within the last month before enrolment into the study) under treatment with a long-acting inhaled bronchodilator (laba and/or lama) alone or in combination with an inhaled corticosteroid * written consent for participation in the study * patients who are able to complete by themselves in greek a questionnaire on copd. exclusion criteria: * patients with diagnosed asthma * patients with any psychiatric, neurological or other disorder render them unable to complete the copd questionnaire by themselves * the patient participates in another study.

Keywords: chronic obstructive pulmonary disease, symptoms
effect of solution-focused approach on the internet,social media addiction and self-efficacy levels ofnursing students

Conditions: Risk Behavior; Social Media Addiction; Internet Addiction

Summary: the purpose of this research; is to determine the effect of solution-oriented approach on internet, social media addiction and self-efficacy levels of nursing students. a pretest-posttest randomized controlled experimental design will be used in the research.

the research will be carried out between 4 april 2022 and 28 april 2023 at sivas cumhuriyet university . personal information form, internet addiction scale, social media addiction scale and self-efficacy competence scale were applied to a total of 1057 nursing students who were continuing their education in the 1st, 2nd and 3rd years at the faculty of health sciences (683) and suşehri health college (374), where the research would be conducted.since the final data of the study will be received next year, students in the 1st, 2nd and 3rd grades will be included in the interviews in order to prevent data loss, and 4th graders will be excluded from the study.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-25, * 67 \< internet addiction scale (ias) score \< 109, * 73 \< social media addiction (smds) score \< 140. exclusion criteria: * receiving any psychological counseling and treatment, * being closed to communication, * to have extended the term, * not volunteering to participate in the research.

Keywords: solution focused approach nursing internet addiction social media addiction self-efficacy-sufficiency
mechanically or kinematically aligned total knee prosthesis

Conditions: Osteoarthritis, Knee

Summary: the mechanical alignment technique (mechanical alignment - ma) of a total knee prosthesis (tka) was developed with the aim of making the installation of a tka simple and reproducible, and that the prosthetic biomechanics are acceptable, thus promoting good longevity of implants. this is a technique that does not aim to restore the constitutional anatomy of the knee; bone cuts are systematically made at fixed angles, in the 3 planes of space, in relation to the mechanical axes of the long bones (femur and tibia). this non-personalized implantation technique therefore systematically alters the anatomy, laxity and kinematics of the knee, causing up to 50% of residual symptoms after prosthetic implantation and 20% of dissatisfied patients. in order to improve the clinical results of tka, a new, more personalized and physiological technique was developed in 2007, called kinematic alignment (ka). this technique aims to restore the pre-arthritic anatomy, unique to each knee. patients with severe constitutional deformity of the lower limb therefore retain this deformity after kinematic prosthetic replacement. the impact of the alignment technique on the biomechanics of the prosthetic knee remains poorly described. the main objective of this study is therefore to compare knee biomechanics between mechanical tka and kinematic tka.


Eligibility criteria:
inclusion criteria: * patient followed as part of a consultation 1 year after tka placement * adult patient * patient affiliated to a social security system * patient informed of the study and formally included (signing of informed consent) before the first research review exclusion criteria: * patient with a contralateral knee prosthesis * patient with another condition (acquired pathology) of the lower limbs (e.g. severe osteoarthritis of the contralateral knee or hip/ankle) and/or of the nervous system (e.g. parkinson's) which may significantly affect the quality of walking * pregnant patient * patient deprived of liberty by judicial or administrative decision, * adult patient subject to a legal protection measure or unable to express consent

Keywords: total knee prosthesis mechanical alignment kinematic alignment biomechanic study
understanding symptom recognition and treatment decision-making in hispanic/latino lung cancer patients

Conditions: Lung Cancer

Summary: the purpose of the study is to understand why hispanic/latino patients with lung cancer are diagnosed later than other groups.


Eligibility criteria:
inclusion criteria: * self-identified hispanic/latino patients with biopsy-proven primary lung cancer treated at mskcc, including stages of disease i-iv * 18 years of age or older * fluent in english or spanish * patients must reside in the u.s exclusion criteria: * spanish-surnamed patients who do not self identify as hispanic/latino (e.g., philippines-born individuals)

Keywords: lung cancer hispanic/latino patients interviews 11-109
99mtc-mip-1404 spect/ct in primary staging of prostate cancer

Conditions: Prostate Cancer

Summary: prostate cancer (pca) is currently the most common cancer in men in finland (www.cancerregistry.fi). although prognosis is very good in majority of men, it is noteworthy that still up to 20% of pca cases are metastatic at the time of initial diagnosis and yearly 900 men die because of prostate cancer. robust primary staging is, therefore, one of the most important prognostic factors, and it is crucial for treatment decision. despite their low sensitivity to detect metastasis, bone scintigraphy (bs) and contrast enhanced whole body computed tomography (ce-wbct) are recommended by current guidelines for primary staging in men at risk of metastasis. mip-1404 is a small-molecule psma inhibitor that can be used in spect systems (99mtc-mip- 1404 spect/ct). 99mtc-mip-1404 spect/ct is performed by a single iv bolus of 99mtc-mip-1404, which binds with high affinity to extracellular domain of psma molecule. as of march 2020, a total of 629 subjects have received 99mtc-mip-1404 injection averaging 740 ±111 mbq (20 ± 3 mci) per administration in prospective clinical trials. 99mtc mip-1404 has been well tolerated following a single iv dose at 740 ± 111 mbq in both healthy volunteers and patients with confirmed metastatic prostate adenocarcinoma. in prospective and retrospective studies, it has shown high potential to detect prostate cancer lesions in primary staging. in fact, goffin et al. reported a sensitivity of 50% and specificity of 87% detecting local lymph node metastasis in radically operated patients when histopathology was used as a reference. this corresponds closely to the sensitivity of psma-pet. prostamip is a randomized prospective single-institutional study to demonstrate superiority of 99mtc-mip-1404 spect/ct compared to traditional imaging modalities (99mtc-hmdp planar bs plus ce-wbct).


Eligibility criteria:
inclusion criteria: * subjects must be able and willing to give written informed consent and to comply with the requirements of this study protocol * subjects must be male, aged 18 years or above at baseline * histopathologically confirmed high risk (gleason ≥4+4, psa ≥20 and/ or ct≥3a) acinar or ductal adenocarcinoma of prostate exclusion criteria: * allergy/sensitivity to study medications or their ingredients * subjects unable to provide written informed consent * subjects who have any other significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk by participation in the study, or may influence the result of the study. * subjects who have a history of drug or alcohol use that, in the opinion of the investigator, would interfere with adherence to study requirements. * subjects who have androgen deprivation therapy initiated before enrolment * subjects who have claustrophobia

Keywords: psma pet spect
the effect of intravenous tranexamic acid and interscalene block applied on shoulder arthroscopy

Conditions: Nerve Block; Tranexamic Acid

Summary: nerve blocks are used for pain and surgery after many operations today. it has been demonstrated by studies that the amount of postoperative bleeding decreases. on the other hand, surgical teams can use additional medications, such as tranexamic acid, which have been proven by different studies that have reduced bleeding during and after arthroscopic surgery.

the investigators aimed to investigate the effect of interscalene block application and tranexamic acid on bleeding in shoulder arthroscopy operation.

Eligibility criteria:
inclusion criteria: * patients who were in the american society of anesthesiologists (asa) i-iii class * underwent elective shoulder arthroscopy * patients with consent to participate in the study exclusion criteria: * history of arterial or venous thromboembolic disease * bleeding diathesis disorder * allergy to local anesthetics * cardiac stent placement
selective lymph node dissection for ct1n0m0 invasive nsclc with ctr>0.5 located in the apical segment (ectop-1018)

Conditions: Lung Adenocarcinoma; Lymph Node Metastasis

Summary: this is a clinical trial from eastern cooperative thoracic oncology project (ectop), numbered as ectop-1018. the goal of this clinical trial is to confirm the theraputic effect of selective lymph node dissection for ct1n0m0 invasive non-small cell lung cancer with ctr\>0.5 located in the apical segment. the main questions it aims to answer are: the 5-year overall survival of patients having ct1n0m0 invasive non-small cell lung cancer with ctr\>0.5 located in the apical segment; the post-operative lymph node metastasis and recurrence-free survival. participants will receive selective lymph node dissection as the surgical procedure.


Eligibility criteria:
inclusion criteria: 1. patients who sign the informed consent form and are willing to complete the study according to the plan; 2. aged from 18 to 80 years old; 3. ecog equals 0 or 1; 4. not receiving lung cancer surgery before; 5. resectable peripheral ct1n0m0 tumors with ctr\>0.5 located in the apical segment; 6. non-lepidic predominant invasive nsclc dignosed by frozen section; 7. not receiving chemotherapy or radiotherapy before. exclusion criteria: 1. not ct1n0m0; 2. nodules not located in the apical segment or ctr≤0.5; 3. pre-invasive lung adenocarcinoma, lepidic predominant adenocarcinoma, or not lung adenocarcinoma diagnosed cytologically or pathologically; 4. receiving lung cancer surgery before; 5. receiving radiotherapy or chemotherapy.
perfusion quality odds

Conditions: Cardiac Disease; Extracorporeal Circulation; Complications; Perfusion; Complications; Acute Kidney Injury

Summary: cardiac surgery-associated acute kidney injury (csa-aki) is a frequent complication after cardiac operations with cardiopulmonary bypass (cpb) use. its frequency varies depending on the severity grade. there are different "static" predictive scores for the csa-aki based on the patient and surgery-associated parameters. recently, in our institution was developed a predictive algorithm for csa-aki that starts with a static model and then integrated with 7 cpb-associated parameters: hct, do2, time of exposure to a critical do2, systemic pressure, cpb duration time, lactate value, transfusion of red blood cells (rbc), that together build a dynamic perfusion risk (dpr) associated to the cpb. combining the static and dynamic models produces the multifactorial dynamic perfusion index (mdpi). the present study validates mdpi in a new prospective series of patients undergoing cardiac surgery with cpb.

cardiac surgery-associated acute kidney injury (csa-aki) is a frequent complication after cardiac operations with cardiopulmonary bypass (cpb) use. its frequency varies depending on the severity grade which for the present study follows the akin criteria. there are different predictive scores for the csa-aki based on the patient and surgery-associated parameters. these models could be defined as "static". it's known that a number of cpb-associated parameters could influence csa-aki, as well. these include hematocrit (hct), oxygen delivery (do2), time of exposure to a critical do2, and perfusion pressure. these parameters, taken separately, are associated with csa-aki development. recently, our institution has developed a predictive algorithm for csa-aki that starts with a static model and then integrated with 7 cpb-associated parameters: hct, do2, time of exposure to a critical do2, systemic pressure, cpb duration time, lactate value, transfusion of red blood cells (rbc), that together build a dynamic perfusion risk (dpr) associated to the cpb. combining the static and dynamic models produces the multifactorial dynamic perfusion index (mdpi). mdpi has higher discrimination power when compared to the static scores, in the original series and in the internal validation with the bootstrap technique. the present study validates mdpi in a new prospective series of patients undergoing cardiac surgery with cpb. an enrollment of 400 patients is anticipated with a stopping rule for efficacy at interim analysis (for primary endpoint) at 50% enrollment (200 patients) if the c-statistics for any stage of csa-aki reaches at least 0.75. futility is defined as an auc of 0.6 or lower.

Eligibility criteria:
inclusion criteria: * patients undergoing cardiac surgery with cardiopulmonary bypass * age of 18 years and higher * willingness to participate and sign the informed consent exclusion criteria: - patients requiring preoperative dialysis

Keywords: acute kidney injury cardiopulmonary bypass cardiac surgery risk score
changes in ocular rigidity after trabeculectomy in patients with poag

Conditions: Glaucoma; Primary Open Angle Glaucoma; Pseudoexfoliation Glaucoma

Summary: it has been hypothesized that the biomechanical properties of the optic nerve head and/or sclera play a role in the development of glaucoma. one approach of gaining insight into the biomechanical properties of the eye by the means of clinical studies is based on the friedenwald equation, representing a pressure-volume relationship. this equation represents the so called ocular rigidity, which expresses the elasticity of the globe. in order to be able to solve the equation, measurements of fundus pulsation amplitude (fpa) with laser interferometry and dynamic contour tonometric assessment of the pulse amplitude (pa) have to be performed. in addition choroidal thickness will be assessed with oct before and after trabeculectomy, since results in choroidal thickness measurements in patients with glaucoma are controversial. the focus of this study lies on the changes of ocular rigidity and choroidal thickness after surgical trabeculectomy in patients with primary open angle glaucoma (poag) or pseudoexfoliation glaucoma (pex).


Eligibility criteria:
inclusion criteria: * men and women aged over 18 years * normal ophthalmic findings except poag or pseudoexfoliation glaucoma (pex) * patients scheduled for trabeculectomy exclusion criteria: * participation in a clinical trial in the 3 weeks preceeding the study * symptoms of a clinically relevant illness in the 3 weeks before the first study day * presence or history of a severe medical condition that will interfere with the study aim as judged by the clinical investigator * other types of glaucoma, such as pigmentary glaucoma, history of acute angle closure * history of previous glaucoma surgery * postoperative iop ≤ 8 mmhg * ocular inflammation or infection within the past 3 months * topical treatment with any ophthalmic drug except anti-glaucomatous medication

Keywords: trabeculectomy
multi-target tracking in prostate radiotherapy using mlc and kim

Conditions: Prostate Cancer

Summary: assessing the feasibility of implementing real-time multi-leaf collimator (mlc) tracking to account for the relative motion of the moving prostate tumour target and the static pelvic nodal target for high-risk prostate cancer patients. the capability of tracking for the relative motion of multiple targets will ensure that all the treatment targets receive correct dose as prescribed by the doctor and minimise side effects to the critical organs.

this study will assess the feasibility of implementing real-time multi-leaf collimator (mlc) tracking to account for the relative motion of the moving prostate tumour target and the static pelvic nodal target for high-risk prostate cancer patients. the capability of tracking for the relative motion of multiple targets will ensure that all the treatment targets receive correct dose as prescribed by the doctor and minimising side effects to the critical organs. during radiation treatment, the prostate position will be monitored in real time using the kim technology. the nodal target will be imaged before and after each treatment to evaluate the nodal treatment margin. the mlc tracking is implemented by recalculating the radiation beam shape fit for the moved prostate and static nodal targets and sending the adjusted mlc leaf positions to the treatment delivery system. the actually delivered dose to the patient will be calculated after the treatment and compared to the dose without mlc tracking to assess the treatment efficacy.

Eligibility criteria:
inclusion criteria: * patients undergoing definitive external beam radiotherapy at northern sydney cancer centre * patients histologically proven prostate adenocarcinoma * psa obtained within 3 months prior to enrolment * pelvic lymph nodes are included for treatment for patients at stage t1c-t3b with gleason 8-10 or prostate-specific antigen (psa) \> 20 ng/ml or pelvic lymph node positivity on conventional imaging or prostate-specific membrane antigen (psma) scans. * patient must be able to have gold fiducial markers placed in the prostate * eastern cooperative oncology group (ecog) performance status 0-2 * ability to understand and the willingness to sign a written informed consent document. * prostate dimension that allows leaf span with tracking margin of ±8mm exclusion criteria: * patients with artificial hip(s), lumbar spinal surgical rods or other large metallic pelvic implants * patient's dimensions \>40cm as measured at the level of the prostate * patients with overlapping implanted gold fiducials in x-ray imaging

Keywords: prostate radiotherapy igrt vmat image-guided radiation therapy volumetric modulated arc therapy adaptive radiotherapy
"mobile stroke unit"-concept for delivery of specialized acute stroke care to patients in remote areas

Conditions: Acute Stroke

Summary: treatment of acute stroke must be fast. the aim of this trial is to show feasibility, safety and clinical benefit of a strategy of diagnosis and treatment directly at the emergency site for hyperacute treatment and transfer to the most appropriate target hospital. the effects on reduction delays until different stroke treatments will be assessed. first estimations of cost-effectiveness will also be performed.

stroke is a medical emergency for which "time-is-brain". indeed, a huge body of animal experimental and clinical evidence exists that demonstrates that reducing the time to thrombolytic therapy is the most important variable in prevention of the disability. however, most stroke patients arrive to hospital too late for any type of acute stroke treatment: only an estimated 19-60% of stroke patients present within 3 hours after symptom onset. today, for stroke patients 3 different treatment options exist. 1. thrombolysis with recombinant tissue plasminogen activator (rt-pa) is an effective treatment for many acute stroke patients as evidenced by several large randomized trials. 2. more recently, mechanical clot removal via catheters has been developed. there is currently increasing evidence that in obstruction of large brain vessels such endovascular treatment is superior to systemic thrombolysis in regard to recanalization rates and outcome. 3. patients with intracranial hemorrhage can profit if transferred to hospitals with neurosurgical treatment options such as ventricular drainage or hematoma removal. however, each of these treatment are highly time sensitive and due the availability of endovascular and neurosurgical treatment options only in very few highly specialized neurovascular centres decision in which institution the patient should be transported is of high medical and financial relevance. the aim of this trial is to show feasibility, safety and clinical benefit of a strategy of diagnosis and treatment directly at the emergency site and its role in decision regarding transfer to appropriate target institution, thus potentially allowing reduction of time until treatment and delays until specialized treatment also in remote regions. first estimations of cost-effectiveness will also be performed.

Eligibility criteria:
inclusion criteria: * symptoms of acute stroke reported to the ems dispatcher office (extended fast score, table i) and verified by the ems (after glucose testing) * reported onset of symptoms until call ≤ 8 hours * patients with "wake up stroke" * age older than 18 years * patient (or representative) is willing to participate voluntarily and to sign a written informed consent. exclusion criteria: * cardiopulmonary unstable medical conditions requiring immediate treatment in an intensive care unit * patients with preexisting severe functional impairment and disease * known allergy or contraindications to contrast agents

Keywords: acute stroke prehospital treatment