Kornimate/medical-research-clean huggingface dataset:
impact of aspiration thrombectomy during carotid stenting

Conditions: Carotid Artery Stenosis

Summary: the purpose of this study is to determine whether aspiration thrombectomy following carotid stent deployment will reduce the number of procedure related signals as identified by diffusion weighted mri of the brain.

studies have demonstrated that carotid artery stenting is a safe and effective alternative to carotid endarterectomy for high or standard risk patients with symptomatic stenosis. despite the routine use of embolic protection devices, numerous studies have shown that carotid stenting is associated with a higher degree of intracranial emboli by diffusion-weighted mri of the brain. a potential solution to minimize this effect is the use of aspiration prior to distal embolic protection removal.

Eligibility criteria:
inclusion criteria: * ica stenosis greater than 50 percent by carotid angiography * documented hemispheric ischemic stroke, tia, amaurosis fugax, or retinal stroke in the last six months ipsilateral to the stented lesion exclusion criteria: * subject less than 40 years of age * pregnant subjects * asymptomatic carotid stenosis * total occlusion of target carotid artery * inability to deploy distal protection device or stent in target vessel * allergy to both aspirin and approved thienopyridine anti-platelet drugs (clopidogrel/ticlopidine) * multiple carotid stenoses in same vessel that cannot be covered by single stent * ipsilateral intracranial stenosis requiring treatment * isolated common carotid stenosis * stenosis less than 50 percent by angiography * chronic or paroxysmal atrial fibrillation not treated with warfarin or dabigatran. * life expectancy less than 30 days * active bleeding diathesis * suspected myocardial infarction within 72 hours prior to carotid stenting * presence of intracranial tumor arteriovenous malformations or aneurysm requiring treatment * inability to undergo dwmri * unwillingness to participate or provide consent * subjects using a legally authorized representative for consent for participation * concurrently enrolled in another study * stroke, tia, amaurosis fugax ipsilateral to the treated lesion more than 6 months from randomization * occlusive or critical ilio-femoral disease that precludes safe femoral access to the aortic arch * severe atherosclerosis of the aortic arch or origin of the innominate or common carotid arteries * prior large stroke, multiple lacunar infarcts, or dementia * stenosis that contain visible thrombus

Keywords: symptomatic carotid artery stenosis
alleviating effects against dry eye by oral intake of cordyceps cicadae mycelia

Conditions: Dry Eye; Supplement

Summary: cordyceps cicadae mycelia was tested for amelioration of dry eye symptoms through dietary supplementation. its efficacy in relief of human dry eye status was assessed by randomized, double-blinded tests, including multiple assessments. the results were compared between the placebo group and the experimental group.

former animal studies had shown that cordyceps cicadae mycelia can effectively ameliorate uvb-induced dry eye symptoms. this study further investigated its efficacy in human dry eye status by randomized, double-blinded tests, including dry eye questionnaires, blood tests, salivary tests, tear volume test, intra-ocular pressure assessments, ocular surface photography, corneal fluorescein stain, tear film breakup time test, fundus photography, and cornea impression cytology. all tests were performed again after 3 months of dietary supplement of either samples or placebo. a total of 97 participants completed the trial. the data were analyzed by paired-t test and compared between the placebo and the experimental groups.

Eligibility criteria:
inclusion criteria: * adults aged from 20 to 60 with dry eye symptoms confirmed by ophthalmologists, and without chronic diseases. exclusion criteria: * those vulnerable to damages or loss of self-conscious, or behavior capacity, or with major illness or with critical diseases.

Keywords: dry eye cordyceps cicadae mycelia
interest of pulse wave velocity measurement as a predictor of severity of aortic stenosis

Conditions: Pulse Wave; Aortic Stenosis

Summary: aortic valve pathology is the third most common cardiovascular disease after coronary artery disease and hypertension, which is responsible for severe morbidity and mortality in elderly patients and requires surgical treatment in its most severe form of progression. the purpose of this study is to find a link between arterial stiffness and degenerative aortic stenosis. if this link is established, arterial stiffness may become a medical therapeutic target in order to delay the evolution of the disease.


Eligibility criteria:
inclusion criteria: * patients over 18 years of age, without legal protection (guardianship or curatorship), * stable hemodynamic status. * affiliation to a social security scheme exclusion criteria: * hemodynamically unstable patients: systolic pa \<10 cmhg, rapid peripheral pulse and spinning, mottling, obnubilation, oliguria, sweating, coma * history of significant valvulopathy other than an aortic stenosis, * pregnancy. * patient under tutelage or curatelle or deprived of public right.
effect of water exchange plus acetic acid staining on the detection of flat polyps during colonoscopy

Conditions: Adenoma Colon

Summary: our previous study (am. j. gastroenterol. 2017 04;112(4)) showed that water exchange (we) colonoscopy was able to increase the detection of flat adenomas as well as overall adr. we hypothesized that we based whole-colon acetic acid（aa） staining might be useful to improve the detection of flat lesions compared with we alone.

water exchange colonoscopy was performed as described previously (am. j. gastroenterol. 2017 04;112(4)). patients were randomly allocated to we group or we+aa group. in we+aa group, water containing 1% of aa was used during insertion of colonoscopy instead of water alone. a bottle of 20ml pure aa was placed abutting the water pump, which make it possible to keep patients blinded to group allocation. endoscopist using a high-definition wide-angle olympus or fujinum colonoscope performed all of the colonoscopies, with a withdrawal time of at least 6 min. the observation was initially performed without the assistance of cap or the use of magnification or electronic staining (nbi, bli, lci or afi et al.). scopolamine butylbromide or glucogon was not routinely administrated.

Eligibility criteria:
inclusion criteria: * aged 40-70 * undergoing colonoscopy after standard bowel preparation exclusion criteria: * known familial polyposis * small amount of feces or semi-solid stool in last rectal effluent * inflammatory bowel disease * lactated or pregnant women * unable to provide informed content

Keywords: water exchange colonoscopy flat polyps acetic acid staining
iort-breast at medical center navicent health

Conditions: Breast Cancer Female; Early-stage Breast Cancer

Summary: intraoperative breast radiation therapy (iort-breast) utilizing the xoft axxent electronic brachytherapy system (xoft) has been recently introduced as a treatment option for women 50 years of age and older who have early stage, low risk invasive breast cancer (ibc). clinical trials have shown iort to be non-inferior to whole breast radiation, however some concern continues with rates of recurrence and clinical outcomes. given the recent introduction and continued debate it is an excellent opportunity to observe and monitor outcomes in the patients that are treated at navicent health through this prospective, observational registry. the opportunity also permits examination of the participant's thoughts and feeling on quality of life and cosmetic appearance

objectives: (primary and important secondary objectives) the primary objective is to determine rates of recurrence at 5, and 10 years following iort-breast at navicent health. secondary objectives include determination of acute and late effects of iort-breast at the treatment site, cosmetic outcomes and satisfaction over 10 years. in addition, the study will determine why patients who were scheduled for iort-breast did not receive it after lumpectomy. study design: prospective, observational registry. setting/participants: the study focuses on outpatients/short stay surgery performed at the medical center, navicent health, macon, ga only. participants have been deemed eligible for iort-breast or have received iort-breast within the last 6 months. key eligibility criteria for iort- breast includes women, aged 55 years old or greater, diagnosed with clinically node negative, grade 1 or 2 invasive breast cancer with no lymphovascular invasion, that is 20mm or less in greatest dimension, estrogen receptor (er) positive, her 2 neu negative, and with a depth greater than 10mm from skin. study interventions and measures: participants will be eligible for iort-breast or have received iort-breast in the previous 6 months. participants who were scheduled for iort-breast and do not receive iort-breast will have reasons for not receiving iort-breast recorded and will not be followed further. participants receiving iort-breast will have treatment parameters recorded and will be followed every 6 months for 2 years and then annually until up to 10 years following treatment.

Eligibility criteria:
inclusion criteria: * signed informed consent and hipaa authorization * t1 tumor (less than or equal to 20mm in greatest diameter) * unifocal * histological grade 1 or 2 * node negative * er +ve * her-2 -ve exclusion criteria: * previous radiation therapy to the involved breast other than iort within 6 months * high grade tumors (histologic grade 3) * her-2 positive * lymphovascular invasion * metastatic disease * close proximity to or involvement of skin * multifocal cancer

Keywords: intraoperative radiation therapy
heavy slow resistance training in adults with frozen shoulder

Conditions: Frozen Shoulder

Summary: the aim of the study is to evaluate the efficacy of heavy slow resistance exercise in patients diagnosed with frozen shoulder using randomized controlled trial design


Eligibility criteria:
inclusion criteria: * unilateral painful, restricted active and passive range of motion of the shoulder, with loss of passive external rotation of at least 50% compared to opposite side at 0 deg of abduction * symptoms present for at least 3 months * normal x-rays on anteroposterior, axillary and lateral views exclusion criteria: * severe degeneration, or trauma involving the shoulder * inflammatory joint disease affecting the shoulder. * pain or disorders of the cervical spine, elbow, wrist, or hand * stroke or peripheral nerve neuropathy injection with corticosteroids in the affected shoulder in the preceding 4 weeks.

Keywords: frozen shoulder heavy slow resistance isometrics eccentric exercise muscle guarding
comparison between aesthetic functional appliances and twin block in correction of skeletal class ii

Conditions: Skeletal Malocclusion

Summary: the goal of this is to evaluate the skeletal, dental and soft tissue effects between aesthetic functional appliance and twin block appliance in treatment of skeletal class ii in ( growing male/female patients)

the sample will be randomly divided into 2 equal groups according to the appliance will be used: group 1: aesthetic functional appliance group 2: twin block methods: \*radiographs (cbct) will be taken before starting the treatment (t1) and after obtaining class i occlusion and normal overjet (t2) by sequential appliances. appliances. * lateral cephalograms -extracted from cbct- will be used to evaluate the effect of the two appliances. * cbct will be used to evaluate root resorption and bony changes in the condyle .

Eligibility criteria:
inclusion criteria: * skeletal class ii pattern with anb angle exceeding 6° and wits appraisal of 2 mm or more. * mandibular deficiency (snb angle less than 77°). * growing patients. * no prior orthodontic intervention. * the vertical skeletal classification shows a horizontal or neutral growth pattern. * overjet ≥ 8mm. exclusion criteria: * developmental abnormalities with atypical or irregular patterns of growth and maturation. * any indications or manifestations, as well as any prior medical records, of tempro-mandibular joint (tmj) disorders, such as the presence of clicking, pain, limitations, or deviations.

Keywords: classii mandibular advancement twin block
anxiety on the first day of chemotherapy

Conditions: Breast Cancer; Anxiety

Summary: investigating chemotherapy anxieties

breast cancer is the most common type of cancer in women in the world, and it is the first in cancer-related deaths in women all over the world. in the treatment of breast cancer, in addition to surgery, patients with advanced stage or high risk of recurrence receive neoadjuvant and adjuvant chemotherapy treatments. this period starts with 3 months and extends according to the treatment protocols it will receive. since the first diagnosis of breast cancer, it has psychological effects such as intense stress, decrease in quality of life and anxiety as well as physical effects on patients. the time spent in the "waiting room" while patients are examined and receiving treatment before chemotherapy inevitably has an effect on their anxiety. in this study; it was aimed to investigate the effects of environmental factors in waiting rooms on patients' anxiety.

Eligibility criteria:
inclusion criteria: * to receive chemotherapy for breast cancer for the first time * give consent for the study exclusion criteria: * not approving to participate in the study
diffusion tensor imaging of myelopathy

Conditions: Myelopathy

Summary: myelopathy describes any neurologic deficit related to the spinal cord. myelopathy is caused by various pathological states of the human spinal cord, including tumors, inflammatory lesions, spinal cord compression and degenerative myelopathy. clinically, the diagnosis of myelopathy depends on localization of the neurologic finding to the spinal cord, rather than the brain or peripheral nervous system and then to a particular segment of the spinal cord. magnetic resonance imaging (mri) plays an essential role in the diagnosis and follow-up of the lesions of the spinal cord using conventional mri t1- and t2-weighted sequences. sometimes a studied spinal cord may appear normal on conventional mri even though patients have symptoms of myelopathy causing a discrepancy between mri findings and clinical findings. diffusion tensor imaging (dti) is an advanced non-invasive mr imaging technique which assesses the microstructural integrity of nerve fiber tracts.

a number of 70 patient with myelopathy included within the study. dti is used primarily for assessing white matter of the brain and spinal cord. dti can depict alterations to the white matter tract and quantify these changes. disturbances of diffusion (restriction or increase) may be assessed quantitatively by measurements of apparent diffusion coefficient (adc). the apparent diffusion coefficient (adc), is used to measure diffusive strength. diffusion anisotropy can be assessed quantitatively by using the fractional anisotropy (fa) parameter, which may be also visualized on fractional anisotropy maps. fa is considered as a marker of white matter integrity. image acquisition will be conducted on a 1.5-tesla mr scanner. the imaging will be done throughout the following sequences: 1. conventional mri sequences: sagittal t1w, sagittal and axial t2w sequences. 2. dti sequence: single-shot spin-echo echo-planar imaging (epi) and parallel imaging techniques to achieve motion-free and higher signal-to-noise ratio (snr) dti. post processing: the diffusion-tensor imaging data is transferred to an offline workstation utilizing software used for reconstruction of the diffusion tensor imaging (dti) with regions of interest were defined and measured on the adc and fractional anisotropy (fa) maps. diffusion tensor tractogram will be constructed on the acquired data source.

Eligibility criteria:
inclusion criteria: * clinical symptoms of myelopathy exclusion criteria: * previous spine surgery * spine radiation therapy * cerebral palsy * contraindication to mr imaging.
repair of flexor tendon injuries with eight strand core stitch without postoperative splinting

Conditions: Flexor Tendon Repair

Summary: evaluation of early active postoperative mobilisation in flexor tendon injuries without postoperative splinting

flexor tendon injuries are a common event as the tendons lie close to the skin and so are usually the result of either lacerations such as those from knives or glass, from crush injuries and occasionally they can rupture from where they are joined at the bone during contact sports such as football, rugby and wrestling. flexor tendon injuries are a challenging problem for orthopaedic surgeons due to three main reasons. firstly, flexor tendon injuries of the hands are a clinical problem because they cannot heal without surgical treatment, as the two ends need to be surgically brought together for the healing to occur unlike other tendons including the achilles tendon where it could be placed into plantar flexion to heal. secondly postoperative management needs to be carefully planned as mobilisation has shown to be essential to prevent adhesions and improve gliding but this can risk rupture. lastly due to the unique anatomy of the tendons running through flexor tendon sheaths to function, surgeons need to plan preventing increasing the bulkiness of the tendon through its sheath, which is not always possible from scarring as this affects the functional outcome of the tendon -_ the ultimate goal of surgical intervention has remained constant: to achieve enough strength to allow early motion, to prevent adhesions within the tendon sheath, and to restore the finger to normal range of motion and function. * the successful repair requires minimal gapping at the repair site or interference with tendon vascularity, secure suture knots, smooth junction of tendon end and having sufficient strength for healing. * the strength of the core suture is one of the important factors for valid flexor tendon repair. it is obvious that an increased strand number increases repair gap resistance and strength

Eligibility criteria:
inclusion criteria: 1. adult patient ( \> 16 years) 2. flexor tendon injuries zones (ii,iii,iv,v) exclusion criteria: 1. patients \< 16 years 2. flexor tendon injuries zone i 2- fracture of hand,wrist or forearm bones 3- associated nerve injuries
18f-fspg pet/ct in diagnosing early lung cancer in patients with lung nodules

Conditions: Cigarette Smoker; Current Smoker; Former Smoker; Multiple Pulmonary Nodules; Pulmonary Nodule

Summary: this phase ii trial studies how well 18f-fspg positron emission tomography (pet)/computed tomography (ct) work in diagnosing early lung cancer in patients with indeterminate lung nodules. pet imaging with an imaging agent called 18f-fdg is often used in combination with a pet/ct scanner to evaluate cancers. giving 18f-fspg before a pet/ct scan may work better in helping researchers diagnose early lung cancer in patients with lung nodules.

primary objectives: i. comparison of fluorine f 18 l-glutamate derivative bay94-9392 (18f-fspg) accumulation with fludeoxyglucose f-18 (18f-fdg) accumulation to assess whether (4s)-4-(3-18f-fluoropropyl)-l-glutamate (18f-fspg)-pet is better at discriminating between benign and malignant nodules. secondary objectives: i. to develop and validate early lung cancer detection biomarkers that would directly impact the growing need to integrate imaging and non-invasive molecular diagnostics for indeterminate pulmonary nodules and allow physicians to avoid unnecessary invasive procedures in patients with benign lung disease. outline: patients receive 18f-fspg intravenously (iv) and, undergo a pet/ct scan over 30-60 minutes. within 24 hours-14 days, patients receive 18f-fdg and undergo a second pet/ct scan over 30-60 minutes. after completion of study, patients are followed up within 24-72 hours.

Eligibility criteria:
inclusion criteria: * pulmonary nodule between the size of 7 to 30 mm. subjects with multiple nodules may be eligible if the dominant nodule is 7 to 30 mm * undergoing standard of care 18f-fdg pet imaging (for indeterminate pulmonary nodule) * current or former cigarette smoker, with \>= 20 pack years * documented informed consent exclusion criteria: * history or previous diagnosis of lung cancer * cancer diagnosis within the last 5 years * pregnant or nursing

Keywords: indeterminate lung nodule
high-dose therapy treatment in patients with follicular lymphoma

Conditions: Follicular Lymphoma

Summary: follicular lymphomas are a subgroup of b-cell non-hodgkin lymphomas, accounting for 15% to 30% of newly diagnosed lymphomas.1-3 median survival varies from 5 to 10 years depending on the prognostic factors at diagnosis and response to first-line therapy.4-6 whatever the treatment, no plateau appears on survival curves, and virtually all patients relapse; follicular lymphomas are ultimately progressive, and fatal.2,3,5 no reference first-line treatment is clearly defined. one of the most active therapies is still doxorubicin-based chemotherapy with or without interferon.7-9 new therapeutic approaches including purine analogs and anti-cd20 monoclonal antibody are promising and are progressively included in the management of these lymphomas.2,3,10-13 the role of high-dose therapy (hdt) as a salvage treatment for patients with relapsing follicular lymphoma is demonstrated by some authors; several reports have shown the superiority of hdt followed by autologous stem-cell transplantation, purged or unpurged, compared with conventional chemotherapy in terms of no relapse and overall survival.14-18 only a few reports have been published showing hdt results as a first-line treatment for poor-risk patients with follicular lymphoma, and the results remain controversial.19-26 these data prompted the french groupe ouest-est des leucémies et autres maladies du sang (goelams) to conduct a prospective randomized trial using patients with newly diagnosed follicular lymphoma with a high tumor burden. a combined doxorubicin-based chemotherapy associated with interferon was compared to front-line hdt followed by purged autologous stem-cell transplantation.

age 8-60 years old follicular lymphoma not previously treated stage ii bulky, iii or iv an arbor classification high tumor burden

Eligibility criteria:
inclusion criteria: * age 18-60 years old * follicular lymphoma b, c or d (working formulation) * no previous treatment * seronegativity hiv * ecog performance status less than or 2 * eligible for autologous stem-cell transplantation * stage ii , iii or iv ann arbor classification * criterias of high tumor burden * patient's written informed consent exclusion criteria: * age less than 18 years old or more than 60 years old * other type of lymphoma * stage less than 3 or iii-iv (faible masse) * seropositivity hiv * patients with a history of another malignancy except basal cell skin cancer or in situ uterus cancer

Keywords: phase iii study patients with follicular lymphoma