Kornimate/medical-research-clean huggingface dataset:
preparing fim-bcs - a lifestyle modification for african-american breast cancer survivors

Conditions: Hypertension; Obesity; Nutrition, Healthy

Summary: hypertension and obesity are both major risk factors for cardiovascular disease (cvd), a leading cause of death for black women in the united states. the investigators propose examining the feasibility and acceptability of the 12-week rn-chefrx (real nourishment and cooking healthy food is rx) intervention - grocery delivery, cooking classes, and nutrition education - for black women with hypertension and obesity to improve nutritious eating habits and blood pressure control.

the objective of this study is to conduct the rn-chefrx (real nourishment and cooking healthy food is rx) for 12 weeks among black women who are obese and hypertensive living chicago. we propose to 1) pilot the rn-chefrx intervention and measures that will be used to assess blood pressure, bmi status, and sodium intake with 20 black women diagnosed with hypertension and bmi ≥ 30. we will assess the efficacy of the evaluation tools to be used in a future clinical trial at three-time points (baseline, 12 weeks, and 6 months); and 2) assess the feasibility and acceptability of the rn-chefrx intervention using interviews, surveys, and documentary analysis. findings from this study will inform a larger efficacy trial of rn-chefrx to improve dietary behaviors and blood pressure control among black women with hypertension and obesity

Eligibility criteria:
inclusion criteria: * self-identified as black or of african descent * female * ≥ 18 years old * baseline blood pressure ≥130/85 or diagnosed with hypertension and bmi ≥ 30 exclusion criteria: * inability to cook in their homes * cognitive deficits impeding the ability to participate or provide informed consent * current treatment for cancer * liver or renal disease * pregnancy * lack of english language proficiency
dislocation precautions

Conditions: Arthroplasty, Hip Replacement; Arthroplasties, Hip Replacement; Health-Related Quality Of Life

Summary: this study is looking at the impact of giving patients precautions, or restrictions for movement, when undergoing a total hip replacement. have of the participants will receive precautions, while the other half will not receive any precautions.

patients undergoing hip replacements are often told by health care providers to avoid specific positions and activities to decrease the risk of their hip dislocating following their surgery. this, however, results in patients becoming more fearful of moving and leads to limitations in their function and decreased quality of life. previous research has shown that hip dislocations following surgery are most commonly attributed to poor implant position rather than the actions of the patients. teaching precautions takes up healthcare resources and may use finances that are not necessarily required. this study aims to compare groups with half receiving precautions and half not receiving precautions, to assess the impact of precautions on the patients' quality of life.

Eligibility criteria:
inclusion criteria: * receiving a primary total hip arthroplasty (tha) due to osteoarthritis or osteonecrosis * over 18 * willing and able to sign consent exclusion criteria: * receiving a lateral approach hip arthroplasty * cannot make follow up visits
geko neuromuscular stimulator vs thromboembolism deterrent stockings (teds): dvt prevention study

Conditions: Deep Vein Thrombosis

Summary: this study hypothesises that the geko™ device is more efficient than teds in preventing the formation of symptomatic/asymptomatic deep vein thrombosis (dvts), post-surgery.


Eligibility criteria:
inclusion criteria: 1. aged 18 years of age and over 2. free of significant abnormal findings as determined by medical history (specifically an absence of dvt or haematological disorders). 3. has not used any medications (prescribed or over-the-counter including herbal remedies) judged to be significant by the principal investigator during the ten (10) days preceding enrolment. 4. able to understand the patient information sheet and willing to sign the written informed consent form. 5. able and willing to follow the protocol requirements. exclusion criteria: 1. are requiring hip revision surgery 2. history or signs of previous deep or superficial vein thrombosis/pulmonary embolism. 3. evidence of asymptomatic dvt by duplex ultrasound 4. peripheral arterial disease (abpi \< 0.8), varicose veins or lower limb ulceration or ischemia. 5. significant varicose veins, phlebitis or lower limb ulceration or ischemia. ceap grade 4-6. see appendix 2 6. recent surgery within the last 3 months (such as abdominal, gynaecological, hip or knee replacement). 7. recent trauma to lower limb. 8. chronic obesity (bmi index \>40kg/m2). 9. pregnancy. 10. significant history of following diseases i. cardiovascular: recent mi (\< 6 months) ii. percutaneous coronary intervention (pci) with stent (\< 3 months for bare metal stent (bms) and \< 12 months for drug eluding stent (des) iii. moderate to severe ccf, uncontrolled af iv. neurological: stroke, hemiplegia/paraplegia, myopathies v. significant dermatological conditions affecting lower limbs resulting in broken or inflamed skin particularly at the site where the device is to be fitted. vi. clinically significant haematological conditions i.e. coagulation disorders, sickle cell disease vii. psychiatric disorders 11. on lmwh/heparin (prophylactic/therapeutic doses) or warfarin or warfarin stopped recently and replaced by lmwh/ heparin 12. long term steroid with dermatological changes 13. a pulse rate of less than 40 beats/minute 14. a sitting systolic blood pressure \>180 and \ 100 mmhg. 15. any significant illness during the four (4) weeks preceding the hip replacement surgery. 16. participation in any clinical study during the eight (8) weeks preceding the screening period
pulmonary and cardiac effects of e-cigarette use in pulmonary patients who smoke cigarettes

Conditions: Chronic Obstructive Pulmonary Disease; Chronic Bronchitis; Emphysema; Asthma-COPD Overlap Syndrome

Summary: the purpose of this study is to compare the effects of e-cigarettes and continued smoking on pulmonary and cardiac outcomes in a population with established pulmonary disease.

e-cigarettes with nicotine can affect important cardiopulmonary outcomes and likely pose less risk than cigarettes, but they are not harmless. given the existing literature, there is a need for controlled trials of e-cigarette use in populations with cardiopulmonary disease to fill the gaps between these existing examinations. clarifying how the pulmonary and cardiac effects of e-cigarettes compare to use of conventional cigarettes in those with cardiopulmonary disease beyond single acute exposures will provide important new health information that can help inform policy.

Eligibility criteria:
inclusion criteria: * men and women 40 years of age or older * current, every day smoker (5 or more cigarettes per day for one year or longer) confirmed with intake co of 8ppm or greater * established pulmonary disease (chronic obstructive pulmonary disease \[copd\], chronic bronchitis, emphysema, or asthma-copd overlap syndrome) confirmed by physician diagnosis and/or current prescription of medication for treatment (i.e., laba, lama, +/- ics, or combination) * lives and plans to remain in the greater burlington, vt area for the next month * no intention to quit smoking within the next month * speaks english exclusion criteria: * patients who are medically unstable (unstable symptoms, changes in medications or hospitalizations within last 3 months) * inability to conduct in-home measurements.

Keywords: chronic obstructive pulmonary disease pulmonary cardiac cigarettes e-cigarettes smokers
correlation of children's electronic screen time exposure and dental anxiety and behavior

Conditions: Children's Screen Exposure

Summary: this study aims to detect the correlation between children's electronic screen time exposure and dental anxiety and behavior in a group of egyptian children


Eligibility criteria:
inclusion criteria: * healthy children aged 6-to-8-years old * first dental visit * both genders exclusion criteria: * children with mental or neurological disorders. * children with systemic disorders. * children who use medications that could interfere with the central nervous system * children with previous hospitalization

Keywords: dental anxiety
prediction of postoperative acute kidney injury in patients with acute type a aortic dissection using cystatin c

Conditions: Aortic Dissection; Acute Kidney Injury

Summary: the research aimed to predict postoperative acute kidney injury in patients with acute type a aortic dissection preliminarily by exploring the correlation of preoperative cystatin c level and incidence of postoperative acute kidney injury and combining with relevant risk factors.


Eligibility criteria:
inclusion criteria: 1. 18-80 years old 2. acute type a aortic dissection diagnosed by ct angiography exclusion criteria: 1. history of chronic kidney disease 2. history of cardiovascular operation 3. pregnancy status
effectiveness of lumbar facet joint nerve blocks

Conditions: Low Back Pain

Summary: 1. to demonstrate whether: i. facet joint nerve blocks have therapeutic value beyond the duration of local anesthetic effect. ii. adjuvant medications (sarapin and depo-steroids) provide additional relief of lumbar facet joint pain when used with facet joint nerve blocks. 2. to demonstrate whether or not there are clinically significant improvements in function of patients who receive lumbar facet joint nerve block with or without sarapin and depo-steroids (group ii) compared to patients randomized to group i who receive only local anesthetic blocks. 3. to determine the adverse event profile in both groups.

primary outcome measure(s) to demonstrate a clinically significant difference between the patients treated with adjuvants and those patients randomized to group i in the pain status, physical, and psychological status and pain at 3, 6, 12, 18and 24 months post treatment.

Eligibility criteria:
inclusion criteria: * positive for facet joint pain with comparative local anesthetic blocks candidates are over 18 years of age subjects with a history of chronic, function limiting low back pain of at least six months in duration subjects who are able to give voluntary, written informed consent to participate in this investigation subjects who, in the opinion of the investigator, are able to understand this investigation, co-operate with the investigational procedures and are willing to return to the center for all the required post-operative follow-ups the subject has not had recent surgical procedures within the last three months. exclusion criteria: * negative or false-positive response to controlled comparative local anesthetic blocks narcotic use of greater than hydrocodone 100 mg/day, methadone 80 mg or morphine 100 mg, or dose equivalent uncontrolled major depression or uncontrolled psychiatric disorders uncontrolled or acute medical illnesses including coagulopathy, renal insufficiency, chronic liver dysfunction, progressive neurological deficit, urinary sphincter dysfunction, infection, increased intercranial pressure, pseudotumor cerebri, intercranial tumors, unstable angina, and severe chronic obstructive pulmonary disease. chronic severe conditions that could interfere with the interpretations of the outcome assessments for pain and bodily function women who are pregnant or lactating subjects who have participated in a clinical study with an investigational product within 30 days of enrollment patients with multiple complaints involving concomitant hip osteoarthritis, will not be amenable to study due to the overlap of pain complaints. inability to achieve appropriate positioning and inability to understand informed consent and protocol history of adverse reaction to local anesthetic or anti-inflammatory drugs

Keywords: lumbar facet joint nerve block
evaluation of novel antimicrobial hand towels

Conditions: Diarrheal Diseases; Acute Respiratory Infections; Fever; Skin Infection

Summary: in march 2012, the investigators initiated a prospective, cluster-randomized, controlled field trial in kisumu county, located in an area in western kenya which has the highest under-five mortality rate in kenya with 149 childhood deaths per 1,000 live births 9. the study was designed to evaluate the effectiveness of an antimicrobial hand towel (hereafter referred to as towel) in preventing diarrheal diseases, acute respiratory infections, self-reported fever, and skin infections in children \<2 years old.

in march 2012, the investigators initiated a prospective, cluster-randomized, controlled field trial in kisumu county, located in an area in western kenya which has the highest under-five mortality rate in kenya with 149 childhood deaths per 1,000 live births 9. the study was designed to evaluate the effectiveness of an antimicrobial hand towel (hereafter referred to as towel) in preventing diarrheal diseases, acute respiratory infections (aris), self-reported fever, and skin infections in children \<2 years old.

Eligibility criteria:
inclusion criteria: * mother of a child \<2 years old exclusion criteria: * inaccessible enumeration area in the rainy season * multiple eligible children in a single compound * moved between census and round 1
impact of pretreatment emotional distress on survival and the predictive role of peripheral biomarkers in immunotherapy response among gastroesophageal and lung cancer patients

Conditions: Non Small Cell Lung Cancer; Immune Checkpoint Inhibitors; Inflammation; Cancer, Treatment-Related; Emotional Distress; Gastroesophageal Cancer (GC); Biomarkers / Blood; Progression-free Survival, PFS

Summary: this is the prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable gastroesophageal cancer (gec) and non-small-cell lung cancer (nsclc).

this is the prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable gastroesophageal cancer (gec) and non-small-cell lung cancer (nsclc). eligible patients were administered first-line treatment with either immune checkpoint inhibitor or a combination of immunotherapy and chemotherapy upon enrollment. this study will have 2 cohorts: * cohort 1: a prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable gec patients. * cohort 2: a prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable nsclc patients.

Eligibility criteria:
cohort 1 \& 2 inclusion criteria: * meet the diagnostic criteria for cancer (including esophageal, gastric, gej or nsclc) through clinical, pathological, and imaging examinations; * karnofsky performance status (kps) score should be equal to or greater than 80 points; * unresectable locally advanced or metastatic; * systematic treatments naive ( e. g., chemotherapy, anti-angiogenic drugs, targeted drugs, and immunotherapy); * presence of at least one measurable lesion according to the response evaluation criteria in advanced solid tumors version 1.1 (recist v1.1); * receiving pd-1/pd-l1 inhibitors monotherapy or combination with chemotherapy; * informed and agreed to participate in the study; * required to complete the questionnaire independently or with assistance from others if needed; * legal age, 18 years or older. exclusion criteria: * oncogene-driver positive; * combined with other malignant tumors in the past 3 years; * concurrent acute or chronic psychiatric disorders; * current receiving anti-depressive or anti-anxiety therapy or other psychotropic drugs; * previous treatment with other clinical drug trials; * patients with symptomatic brain metastasis; * severe intellectual disabilities or other communication difficulties that hindered normal interaction.
clinical characteristics and microbiology of community-acquired pneumonia

Conditions: Community-acquired Pneumonia

Summary: community-acquired pneumonia has become common. additionally, the mortality is high. but the epidemiology of pathogen is various in different areas, which is crucial for the key treatment. in addition, the risk factors of patients who died in 3 or 7 days in china is not clear, comparing with patients who died in 14 or 28 days or who survived.


Eligibility criteria:
inclusion criteria: * confirmed community acquired pneumonia * age≥18 ys exclusion criteria: * hiv infection

Keywords: pathogen mortality community-acquired pneumonia risk factors
study of standardized treatment of integrative medicine with the severe iga nephropath

Conditions: IgA Nephropathy

Summary: iga nephropathy(igan) is the highest incidence of kidney pathology in the primary nephropathy. in terms of differences in prognosis, severe iga nephropathy,one of the most main primary renal disease,could cause the uremia. it will be significant that early indicators of prognosis and early intervention can be normalized and the scientific criteria for judging the efficacy of great clinical can be established. the subject based on the past study,literature research and various treatment will take the method of multi-center, double-blind, randomized, control to investigate the standard treatment of severe iga nephropathy. otherwise the uniformity and objectivity of traditional chinese medicine (tcm) will be improved by the standardization of tcm research based on the epidemiological investigation and statistical analysis. the subject will determine the efficacy of more sensitive biomarkers and establish more scientific criteria for judging the effect with the application of urine proteomics and metabolomics technologies in order to operate in the formation of the standardization program of the treatment of severe iga nephropathy with the integrative medicine of tcm.


Eligibility criteria:
inclusion criteria: * confirmed by renal biopsy and clinical examination as primary iga nephropathy. * pathology:upon lee's grade ⅲ * age :18-60 years old. * gender and nationality are not limited * chronic kidney disease(ckd) stage 3:（59 ml/min\>gfr\>30ml/min/1.73m2） * 24-hour urine protein:≥1.0g.informed consent exclusion criteria: * patients within the past 3 months had received immunosuppressive agents or cytotoxic therapy is greater than 4 weeks * patients within the past 3 months who have received corticosteroids (prednisone or prednisolone) dose of more than 20mg / d up to 4 weeks * patients suffering from acute or rapidly progressive glomerulonephritis * patients continue with active hepatitis b and abnormal liver function tests transaminase * patients with a history of malignant tumor or malignancy, hiv infection, history of mental illness, acute central nervous system disorders, severe gastrointestinal disease, prohibiting the use of immunosuppressive agents * abnormal glucose metabolism, fasting blood glucose more than 6.2mmol/l * pregnancy or breast-feeding women * receiving other clinical trials * associated with other serious diseases and organ dysfunction * combined life-threatening complications such as severe infection

Keywords: iga nephropathy therapy of chinese medicine
electromyographic analysis and body balance in the use of athletes after cryotherapy by immersion ankle

Conditions: Individual Adjustment; Itch; Athlete

Summary: the influence of cryotherapy on ankle motor control and balance of athletes is controversial. the aim of this study is to assess the neuromuscular response of the dominant leg and body balance basketball athletes after application of cryotherapy. the sample is distributed into two groups. group one will consist of 20 basketball players without a history of ankle sprains in the past 12 months and no complaints of instability in this joint, and group two, 20 non-athletes, active, no complaints in the lower limb in the last 12 months. will perform the inversion movements and single-leg hop for the analysis of the electromyographic signal of anterior tibial, peroneal, gastrocnemius (lateral), rectus femoris, hamstrings and gluteus medius. will also be performed kinematic analysis in search of body balance and range of motion of the joints of the lower limbs. and yet, the analysis of the plantar support and ground reaction force. after the initial collection of the data subjects will be submitted to the application of cryotherapy by immersion in a time of 20 minutes, with a temperature of 6 ± 2 degrees celsius. data collection will be held in pre, 0, 10, 20 and 30 minutes after application of cryotherapy. the data will be statistically analyzed to compare the results in collection times within and between groups. the significance level is set at 5%. the data support the intended use of cryotherapy in motor control of the inversion movement, jump and balance of athletes.

forty male subjects, aged 21.6 (±3.2) yr, 177.9 (±7.9) cm tall, 82.8 (±19.3) kg body weight and 25.9 (±4.8) kg.m-2 body mass index (bmi) were evaluated. skin surface temperature before and after cold-water immersion was 27.7(±3)°c and 7.1 (±1)°c, respectively (p=0,0001).

Eligibility criteria:
inclusion criteria:healthy, active individuals and athletes basketball. - exclusion criteria:patients with muscle or joint injuries in the lower limbs in the last six months; metabolic diseases, rheumatic and orthopedic disabling; patients with balance disorders or cognitive; individuals to submit complaints of muscle fatigue at the time of the tests or they needed the use of stabilizers to realize them; subjects with skin lesions of the lower extremities, hypersensitivity to cold and suffering from diabetes mellitus. -