Kornimate/medical-research-clean huggingface dataset:
the results of ahmed valve operations

Conditions: Glaucoma

Summary: glaucoma drainage devices are usually placed in the superior quadrants. the superotemporal quadrant is usually the site of choice. however, when the upper fornix is scarred and especially when conjunctiva is two fibrotic to enable adequate coverage of tube with a scleral or other patch graft, some surgeons place the tube in one of inferior quadrants.

glaucoma drainage devices are usually placed in the superior quadrants. the superotemporal quadrant is usually the site of choice. however, when the upper fornix is scarred and especially when conjunctiva is two fibrotic to enable adequate coverage of tube with a scleral or other patch graft, some surgeons place the tube in one of inferior quadrants. in the present study we will compare the outcome and complicatons of both the superior and the inferior approach for inserting ahmed valve implants.

Eligibility criteria:
inclusion criteria: 1. patients at the ages of 20-85 on the date of the surgery 2. the indication for the surgery was: uncontrolled glaucoma with maximally tolerated medical therapy who did not or were not expected to respond to other surgical procedures than seton surgery. 3. visual acuity of, at least, 20/800 before the operation. 4. regular post operative follow ups, for at least 1 year. 5. patients after corneal transplantation for whom the indication of valve implantation was uncontrolled glaucoma. exclusion criteria: 1. a previous seton surgery in the operated eye 2. uveitic glaucoma patients or history of uveitis in the operated or in the fellow eye. 3. any inflammatory or ocular surface disease that could affect the healing of the conjunctiva after the surgery ( e.g: ocp) 4. strabismus or complains of diplopia prior to the seton surgery. 5. past history of retinal detachment surgery with scleral buckle in the operated eye 6. past history of endophthalmitis in the operated eye.

Keywords: seton surgery, glaucoma, ahmed valve, intraocular pressure
parkinson progression marker initiative online (ppmi online)

Conditions: Parkinson Disease

Summary: parkinson progression marker initiative online (ppmi online) is an observational study collecting participant reported information from people with and without parkinson's disease (pd), for the goal of better understanding risk and predictive factors for pd. ppmi online is part of the broader parkinson progression marker initiative aimed at identifying markers of disease progression for use in clinical trials of therapies to reduce progression of pd disability.

ppmi is a broad program that is expanding the goals of the original ppmi study, and will include this ppmi online protocol, as well the ppmi clinical \[nct04477785\], ppmi remote, ppmi digital protocols (with external regulatory oversight). all participants in ppmi may be asked to participate in one or all of these protocols and their enrollment in these studies may occur in varying order. ppmi participants may also be asked to participate in additional ppmi companion studies (as they are developed), which may only involve a subset of ppmi participants based on their cohort designation

Eligibility criteria:
inclusion criteria: * parkinson disease (pd) participants: * male or female age 18 years or older. * has received a diagnosis of parkinson's disease participants without pd: * male or female age 18 years or older. * has not received a diagnosis of parkinson's disease

Keywords: parkinson neurodegenerative disorder prodromal at risk participant reported outcomes
pharmacogenomics study on treatment of psoriasis vulgaris by acitretin capsules

Conditions: Psoriasis Vulgaris

Summary: in an early clinical research, 138 patients completed the treatment of psoriasis vulgaris by acitretin capsules in 8 weeks, the results indicate 75 cases effectively (54.3%), 50 cases invalid(36.2%), 13 cases serious(9.4%). to investigate the influence of genetic factors on the curative effect and find the relationships between genetic variants and the response of acitretin capsules to treatment of psoriasis vulgaris.

investigators analyzed the various levels of genetic factors, including: 1.to analysis the key gene variants which associated with adme affect the efficacy of acitretin capsules; 2.direct full genetic sequencing of mhc genes, to explore the genetic variations of efficacy and side effects; 3. direct sequencing of all exons in the gene in the patients of the response of serious and effectively, to explores the rare genetic variation may cause deterioration of treatment by acitretin capsules.

Eligibility criteria:
inclusion criteria: 1. diagnosed according to classification criteria for psoriasis vulgaris 2. patients aged 18 to 70 years (to the date of screening) 3. pasi grade ≥7point 4. not treatment in the topical corticosteroids, immunosuppression, biologicals agents or tretinoin cream, phototherapy nearly one months before enrolled. 5. total bilirubin \< 1.5 x uln, ast(sgot)/alt(sgpt) \<2.5 x uln if not liver metastases\<5 x uln if known liver metastases, creatinine clearance \<1.5 x uln 6. understanding the whole process of the study, voluntary participation and signed the informed consent exclusion criteria: 1. pregnant women, ready to pregnant or lactating women 2. have a serious heart, lung, kidney and other vital organs and endocrine system lesions and the history 3. patients is liver function abnormal persons (alt above the center laboratory normal limit) or hepatitis b patient grain carriers 4. patients with chronic diarrhea, or peptic ulcer nearly 1 year 5. patients suffering from malignant tumor 6. patients suffering from acute and chronic infectious diseases 7. mental disorders, history of alcohol abuse, drug or other substance abuse 8. other cases which researchers believe that can not enroll
what is the effect of prolapse surgery on voiding?

Conditions: Pelvic Organ Prolapse; Stress Urinary Incontinence; Overactive Bladder; Voiding Disorders; Urge Incontinence

Summary: the aim of our study is to examine the effect of prolapse surgery on voiding. our study is the very first one to combine several innovative low-invasive and low-cost methods to analyse the amelioration or deterioration of voiding function after surgery for pelvic organ prolapse using 3d/4d translabial ultrasound, home-uroflowmetry and patient reported quality of life outcomes.


Eligibility criteria:
inclusion criteria: * age ≥18 years * dutch, french or english- speaking women * symptoms of pelvic organ prolapse * preoperatively pelvic floor surgery. exclusion criteria: - history of neurological disease

Keywords: pelvic organ prolapse surgery 3d/4d imaging urinary incontinence voiding dysfunction patient reported outcome
the relationship between lower limb functionality, foot joint position sensation and balance in haemiplegic patients

Conditions: Being Between 40-80 Years Old; Being Diagnosed With Haemiplegia; Getting 20 Points or More in the Mini Mental Test; Volunteering to Participate in the Study; Level 2 or Above According to Functional Ambulation Classification

Summary: stroke is defined as a neurological disorder resulting from acute focal damage to the central nervous system caused by vascular factors, which may include cerebral infarction, intracerebral haemorrhage and subarachnoid haemorrhage. postural balance is a critical factor affecting walking and gait performance in the community after stroke. gait disorders contribute significantly to functional disability in individuals after stroke. these impairments encompass a variety of changes, including muscle weakness in the affected lower limb, resulting in reduced weight bearing on that limb. this results in a slower and less safe gait. given the impact on gait, functional mobility is also compromised, including daily activities such as sitting, standing, walking, turning and climbing or descending stairs. proprioception is impaired in a large percentage of individuals following stroke. the presence of proprioception deficits has been identified as an important determinant of unfavourable functional outcomes after stroke, especially in terms of achieving independence in basic activities of daily living and length of hospital stay. in the literature, there are no studies investigating the relationship between ankle position sense and lower extremity functionality with balance and falls using humac norm isokinetic machine and tecno body prokin isokinetic balance system simultaneously.


Eligibility criteria:
inclusion criteria: * individuals aged 40-80 years * volunteering to participate in the study exclusion criteria: * being diagnosed with vertigo * having a history of serious neurological diseases such as parkinson's disease, multiple sclerosis except hemiplegia * having a previous operation for the lower limb * poor co-operation

Keywords: stroke proprioception lower limb functionality ankle joint balance
tipranavir in patients with progressive, systemic hiv-1 disease who have failed or are intolerant to currently approved treatments for hiv infection

Conditions: HIV Infections

Summary: to provide early access to tipranavir and evaluate the safety and tolerance of tipranavir combined with low dose of ritonavir in patients with progressive, hiv-1 disease who have failed or are intolerant to currently approved treatments for hiv infection, who are unable to participate in another tipranavir controlled clinical trial and have an urgent need for anti-hiv treatment.


Eligibility criteria:
inclusion criteria: patients aho have a positive serology hiv antibody test confirmed by western blot, p24 antigen assay, hiv-1 rna or hiv culture and are highly pre-treated and virus resistant to multiple protease inhibitors.
the effects of ast-120 on endothelial dysfunction in patients with chronic kidney disease

Conditions: Kidney Failure, Chronic

Summary: indoxyl sulfate (is) is a uremic toxin that accelerates the progression of chronic kidney disease (ckd). ast-120 (kremezin®; kureha corporation, tokyo, japan) removes indole, which is the precursor of is, in the intestine, and reduces the accumulation of is. this drug has been shown to retard the deterioration of renal function in ckd patients through reducing the levels of is. is was reported to promote aortic calcification and stimulate the proliferation of vascular smooth muscle cells (vsmc). is also inhibits endothelial proliferation and wound repair. with this background, the investigators will performed the study whether ast-120 improve the endothelial dysfunction in ckd patients.

the purpose of this study is to examine whether kremezin, indoxyl sulfate lowering agent improve endothelial dysfunction in stage 3,4 chronic kidney disease patients

Eligibility criteria:
inclusion criteria: * patients with chronic kidney disease (stage3 - stage4) * patients who are able and willing to understand, sign and date an informed consent document, and authorize access to protected health information exclusion criteria: * acute gastric or duodenal ulcer * severe constipation

Keywords: indoxyl sulfate ast-120
transitional rehabilitation in cabg patients

Conditions: Coronary Artery Disease; Coronary Artery Bypass Graft Surgery

Summary: the goal of this research study is to understand whether an at-home exercise program started soon after cabg surgery, and continuing for 4 weeks following discharge from the hospital, can preserve or improve physical function.

coronary artery bypass graft (cabg) surgery is a common surgical procedures and an important treatment option for coronary artery disease. the post-surgery period of rest and recovery is associated with cardiorespiratory and skeletal muscle deconditioning. the goal of this research study is to understand whether an at-home exercise program started soon after cabg surgery, and continuing for 4 weeks following discharge from the hospital, can serve as a bridge between surgery and the start of cardiac rehabilitation to preserve or improve physical function. volunteers will be randomly assigned to receive neuromuscular electrical stimulation (nmes) of their quadriceps muscles or not to receive nmes (control group). volunteers will be evaluated prior to cabg, upon discharge and 4 weeks post-cabg surgery. assessments will include measurements of physical function by the short physical performance battery, 6 min walk tests and body composition analysis, as well as assessment of subjective physical functional capacity and quality of life using the medical outcomes short form 36. additionally, accelerometry will be used to monitor weight-bearing physical activity during the 4 week treatment phase.

Eligibility criteria:
inclusion criteria: * 50-80 yrs of age * ambulatory * scheduled for coronary artery bypass graft surgery * able to provide informed consent exclusion criteria: * rheumatoid arthritis or other inflammatory/autoimmune disease * cancer, excluding non-melanoma skin cancer * exercise limiting peripheral vascular disease * neuromuscular disease or neuromuscular dysfunction associated with cerebrovascular event * body mass index \>38 kg/m2 * valvular heart disease not corrected surgically * lower extremity blood clot or implantable cardioverter-defibrillator
dynamic contrast enhanced magnetic resonance perfusion imaging in congenital heart disease and lung disease

Conditions: Heart Disease; Cystic Fibrosis; Asthma

Summary: the primary objective of this study is to determine if quantitative dynamic contrast-enhanced magnetic resonance (dce mr) perfusion imaging accurately quantifies right and left pulmonary artery blood flow as compared with phase contrast flow velocity mapping (pc), the current gold standard of flow volume measurements.

many conditions of the heart or the lungs lead to differences in how the blood is pumped to the lungs. specifically, some areas of the lung may receive less blood supply than others. we would like to do a research study in children and adolescents who have a heart condition or a chronic or stable lung condition. we are doing this study to see if measuring the circulation of blood in the lungs in children is possible using magnetic resonance imaging (mri) with a special dye (contrast medium) injection called magnevist®.

Eligibility criteria:
inclusion criteria: cardiac patients: 1. patients \> 6 years of age 2. patients with suspected or confirmed congenital or acquired heart disease 3. who undergo a clinically indicated mri scan, including gadolinium (mri contrast medium) 4. and receive gadolinium (= mri contrast medium) as part of their clinical investigation pulmonary patients: 1. patients \> 6 years of age 2. patients with a chronic and stable lung condition, such as cystic fibrosis, severe asthma. exclusion criteria: 1. children under the age of 6 will be excluded as they are routinely scanned under general anesthesia 2. patients in whom mri is contraindicated (e.g. pacemaker, ocular metal, claustrophobia, tattoos) 3. patients with a known allergy to gadolinium. 4. patients with a history of allergic disposition or have anaphylactic reactions 5. moderate-to-severe renal impairment (defined as having a gfr/ egfr \< 60 ml/min) 6. have sickle cell anemia 7. known pregnancy, or breast feeding 8. patient is uncooperative during a mri without sedation or anesthesia

Keywords: pediatrics heart disease cystic fibrosis severe asthma magnetic resonance imaging
oral colchicine combined with intravitreal infusion of dexamethasone, lmw heparin and 5-fu for management of proliferative vitreoretinopathy (pvr)

Conditions: Proliferative Vitreoretinopathy

Summary: to evaluate the efficacy of oral colchicine combined with intraoperative infusion of dexamethasone, low molecular weight heparin and 5-fu during vitrectomy for management of established proliferative vitreoretinopathy (pvr)


Eligibility criteria:
inclusion criteria: * cases with rhegmatogenous retinal detachment complicated by pvr grade c exclusion criteria: * history of pars plana vitrectomy for pvr grade c * history of silicone oil injection * history of ocular trauma * diabetic retinopathy * glaucoma * giant retinal tear

Keywords: pvr oral colchicine dexamethasone low molecular weight heparin 5-fu
a prospective, experimental, multicenter, open-label, randomized, controlled trial of 3-month dual antiplatelet therapy followed by ticagrelor versus 6-month dual antiplatelet therapy followed by ticagrelor after implanting bridge

Conditions: Brain Disease; Vertebral Artery Stenosis

Summary: to compare the incidence of the composite endpoints of non-fatal ischaemic stroke, transient ischaemia (tia) and all-cause mortality at 12-month follow-up after implantation of bridge for the treatment of symptomatic vertebral artery stenosis in subjects who had been taking different durations of dual-antiplatelet therapy (3 vs 6 months) and ticagrelor monotherapy.


Eligibility criteria:
inclusion criteria: * patients who are suitable for bridge implantation * symptomatic vertebral artery stenosis with a history of posterior circulation-related ischaemic stroke or tia despite the use of at least one antithrombotic medications and intervention for risk factors * responsible vertebral artery stenosis (≥70% stenosis, measured by the nascet method ) confirmed by dsa imaging * the patient and/or his/her authorised person understands the purpose of the study, agrees to participate in the study and signs the informed consent form exclusion criteria: * mrs≥3 * presence of tandem stenotic lesions in the target lesion areaor combined basilar artery stenosis presence of ≥2 stenotic cerebrovascular lesions requiring concurrent intervention the presence of severe tortuosity or calcification of the target vessel, or the presence of extensive abnormal vascular structural variants that are difficult for catheters or stents to pass or cannot be implanted * lesions or stenosis that is too large and beyond the specification of the stent * non-atherosclerotic stenosis such as atrial fibrillation, vasculitis stenosis, arterial entrapment, smoky disease, active phase of arteritis, or unknown cause * contraindication to heparin, aspirin, tegretol, clopidogrel, or other antiplatelet drugs, and those who cannot tolerate anticoagulant and antiplatelet drug therapy * have had intracranial haemorrhage within 3 months * had a myocardial infarction or large cerebral infarction within 2 weeks * accompanied by other intracranial disease such as aneurysm, arteriovenous malformation, intracranial tumour, intracranial infection, etc * presence of active bleeding or extremely dangerous risk of haemorrhage (e.g. active peptic ulcer disease, gastrointestinal lesions with bleeding risk, malignant tumours with bleeding risk, etc.) * severe cardiac, hepatic, splenic, pulmonary, or renal impairment, or allergy or intolerance to contrast media, rapamycin (rapamycin) and its derivatives, cobalt-based alloys, or polylactic acid
the role of anti-reflux surgery for gastroesophageal reflux disease in premature infants with bronchopulmonary dysplasia

Conditions: Gastroesophageal Reflux Disease; Bronchopulmonary Dysplasia

Summary: the purpose of this study is to evaluate the efficacy of fundoplication in premature infants with gerd and bpd.

gastroesophageal reflux disease (gerd) has been postulated to result in chronic aspiration contributing to the development of chronic lung disease, otherwise known as bronchopulmonary dysplasia (bpd) in premature infants. this association has been indirectly based on anecdotal improvement in the respiratory status of infants with bpd after anti-reflux therapy, but the direct causal relationship has been difficult to prove. in addition, the historical evidence for infants with gerd has been based on acid reflux only which is diagnosed by 24 hour intra-esophageal ph monitoring, the gold standard. however, with the introduction of multi-channel intraluminal impedance (mii), gerd can now include non-acid reflux. the contribution of non-acid reflux to the development of bpd in premature infants is unknown. as our understanding of gerd has improved, previous assumptions regarding the efficacy of therapy may no longer be valid. the utilization of anti-reflux surgery (fundoplication) for the treatment of bpd in premature infants with gerd has not been rigorously studied. the efficacy of fundoplication in this patient population has yet to be determined.

Eligibility criteria:
inclusion criteria: 1. must meet all inclusion criteria for initial evaluation of gerd 2. positive ph-mii test for gerd 3. upper gi contrast radiograph to evaluate for associated congenital gastrointestinal anomalies 4. \> or = 2 kg (due to technical limitations of fundoplication) exclusion criteria: 1. previous intra-abdominal surgery except for gastrostomy 2. those deemed not surgical candidates 3. infants with associated congenital gastrointestinal anomalies 4. \> or = 1 year of age at time of initial evaluation of gerd

Keywords: gastroesophageal reflux disease (gerd) bronchopulmonary dysplasia (bpd) fundoplication
treatment outcome after ankle joint surgeries

Conditions: Osteochondral Lesion of Talus; Ankle Arthritis; Instability; Ankle (Ligaments) (Old Injury); Impingement Syndrome of Ankle

Summary: osteochondral lesion of talus (olt), osteoarthrosis and impingement/instability syndrome are most common ankle joint pathologies. this study analyses outcome after various different operative treatment of aforementioned pathologies. investigators hypothesis is that patient characteristics, type of lesion and surgical technique affect the result of treatment. the investigators will compare subjective (questionnaire) and objective (clinical examination) status of patient before and after operation.


Eligibility criteria:
inclusion criteria: * patients with olt treated operatively in department of orthopaedic surgery, umc ljubljana. * patients with ankle joint osteoarthritis treated operatively in department of orthopaedic surgery, umc ljubljana. * patients with ankle instability syndrome treated operatively in department of orthopaedic surgery, umc ljubljana. * patients with ankle impingement syndrome treated operatively in department of orthopaedic surgery, umc ljubljana. exclusion criteria: * patient refuse to participate in study * no respond of patient after invitation to answer a standardized questionnaire (eq-5d, faos, tegner activity score) * no respond of patient after invitation to control examination after operation