Kornimate/medical-research-clean huggingface dataset:
dynamic assessment of right ventricular function with inhaled nitric oxide during cardiac mri

Conditions: Pulmonary Vascular Disorder

Summary: the purpose of the study is to measure rv ejection fraction (rvef), pulmonary flow, and pulmonary perfusion before and after exposure to inhaled nitric oxide in patients with pulmonary arterial hypertension (pah) who are known to be vasodilator-responsive based on invasive catheterization as well as healthy subjects. measurements will also be made after high flow oxygen alone to test the relative vasodilatory effect of oxygen and no. the investigators hypothesize is that inhaled nitric oxide during cardiac mri can be used to measure dynamic changes in rv-pulmonary vascular function in patients with vasodilator-responsive pah.


Eligibility criteria:
inclusion criteria: * patients age 18 or older of the vanderbilt center for pulmonary vascular disease. vasodilator-responsive patients will be identified based on prior response to inhaled nitric oxide during invasive right heart catheterization * healthy subjects age 18 or older not known to have cardiopulmonary disease exclusion criteria: * standard conventional contraindications for cardiac magnetic resonance (cmr) imaging * allergy or contraindication to magnevist (gadopentetate dimeglumine) contrast * concurrent intravenous epoprostenol infusion in whom performance of cmr is cumbersome * pregnant women
bronchoscopy assisted sampling of cells and fluid from the lower respiratory tract of human subjects

Conditions: Respiratory Diseases

Summary: the purpose of this research study is to collect cells and liquid from the air passages of healthy adults, both smokers and non-smokers. these samples will be used for test-tube studies to explore mechanisms of diseases of the respiratory tract, and to compare the samples between people who smoke cigarettes and people who don't. obtaining these samples requires an invasive procedure called "bronchoscopy".


Eligibility criteria:
inclusion criteria: * current cigarette smokers * must be otherwise healthy with no chronic illness exclusion criteria: * asthma * smoking related lung disease (including bronchitis)

Keywords: healthy smokers current cigarette smokers no lung disease
short implants - an alternative to bone grafting?

Conditions: Jaw, Edentulous, Partially

Summary: the study, with the astra tech implant system, is comparing short implants (osseospeed™) to standard length implants (osseospeed™) in combination with bone grafting. the hypothesis is that the use of short implants in posterior maxilla with inadequate bone is as safe and predictable as placing standard length implants in combination with bone augmentation.

this study was designed as an open, prospective, randomized, controlled, multicenter, 5-year follow-up investigation evaluating the outcome of treatment with the osseospeed™ implant 6 mm placed in the posterior maxilla compared to treatment with osseospeed™ implant 11, 13 or 15 mm placed after bone grafting. the study was during the conduct of the study amended to include a 10-year extension cohort.

Eligibility criteria:
inclusion criteria: * provision of informed consent * aged 20-75 years at enrolment * history of edentulism in the study area of at least four months * in need for 1-4 implants in either side of the posterior maxilla (premolar and molar region) * neighboring tooth/teeth to the planned implant/s must have natural root(s) or implant supported restoration, with absence of pathology or excessive bone loss, as judged by the investigator * presence of natural tooth/teeth, partial prosthesis and/or implants in the opposite jaw in contact with the planned crown/s * deemed by the investigator to have a bone height between 5 and 7 mm and a bone width of a minimum of 6 mm * deemed by the investigator as likely to present an initially stable implant situation exclusion criteria: * unlikely to be able to comply with study procedures, as judged by the investigator * earlier bone graft procedures in the study area * uncontrolled pathologic processes in the oral cavity * known or suspected current malignancy * history of radiation therapy in the head and neck region * history of chemotherapy within 5 years prior to surgery * systemic or local disease or condition that could compromise post-operative healing and/or osseointegration * uncontrolled diabetes mellitus * corticosteroids, iv bisphosphonates or any other medication that could influence post-operative healing and/or osseointegration * smoking more than 10 cigarettes/day * bruxism * present alcohol and/or drug abuse * involvement in the planning and conduct of the study (applies to both astra tech staff and staff at the study site) * previous enrolment in the present study * simultaneous participation in another clinical study
phase i/ii study of fractionated stereotactic radiotherapy for early stage non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: a new type of treatment called stereotactic radiotherapy has recently been developed in hopes of improving the success of the treatment and improving the convenience to patients, while reducing the side effects. this study is developing stereotactic radiotherapy as a state-of-the-art treatment for lung cancer patients.

objectives: primary objectives * to determine the efficacy of hypofractionated, image guided radiotherapy in treating patients with lung tumours, with the primary outcome being local control at one year. * to determine the toxicity of high dose, small field,hypofractionated radiotherapy to the lung, based on the rtog and ctcae scales.

Eligibility criteria:
inclusion criteria: * t1-t3n0 non-small cell lung cancer (maximum dimensions of 5cm, t3 by chestwall involvement only) * medically inoperable due to co-morbid conditions or patient preference for radiation * adequate pulmonary function to withstand radical treatment (ie. fev1 greater than 40% of predicted), as assessed by consulting radiation oncologist * age greater than or equal to 18, and karnofsky performance status greater than of equal to 70 exclusion criteria: * presence of mediastinal metastases or distant metastases * life expectancy less than 1 year due to other co-morbid conditions

Keywords: fractionated stereotactic radiotherapy medically inoperable image-guided radiotherapy
comparing surgical techniques for crif of pertrochanteric fractures

Conditions: Femur Fracture

Summary: hypothesis: inflatable intra medullary femoral nailing is superior to dhs in terms of blood loss, operative complications and postoperative rehabilitation in the management of pertrochanteric femur neck fractures.

patients with pertrochanteric fractures of the femur will be randomly assigned to one of 2 groups. group 1 will undergo internal fixation using a dhs device. group 2 will undergo internal fixation using an inflatable intramedullary femoral nail device post operative care will be the same including dvt prophylaxis, early mobilization. weight baring will be aloud in cases of a stable fracture (evans 1-3) non weight bearing until callus bridge in patients with unstable fractures (evans 4-6) outcomes: death within first year postoperative complications length of hospitalization time to mobilization functional score reontgenic evaluation

Eligibility criteria:
inclusion criteria: * pertrochanteric femur fracture * unilateral * age over 60 years * low energy trauma * asa score 0-3 exclusion criteria: * reverse oblique fractures * pathological fractures * severe osteoarthritis of the hip joint * previous operations on same leg * asa score 4-5

Keywords: pertrochanteric femur fracture dhs imn
implementation of fluid strategies using real-time bioelectrical analyzer in surgical intensive care unit (sicu)

Conditions: Fluid Overload; Fluid Loss

Summary: precise assessment of postoperative volume status is important to administrate optimal fluid management. bioelectrical impedance analysis (bia) which measures the body composition using electric character. extracellular water (ecw) ratio by bia represented as the ratio of ecw to total body water (tbw) and is known to reflect the hydration status. based on this, we aimed to determine whether aggressive fluid control using ecw ratio could improve clinical outcomes through a single blind, randomized controlled trial.

critically ill patients admitted to an intensive care unit (icu) after surgery have commonly experienced a large amount of wide organ injury and profuse bleeding resulting in vessel damage during surgery. severe systemic inflammatory reactions and pathophysiological stress could consequently occur in these patients. for patients in an acute postoperative phase, it is important to maintain organ perfusion by correcting hemodynamic instability through fluid resuscitation. bioelectrical impedance analysis (bia), a non-invasive method, is useful for quantitatively measuring body composition such as body fat and muscle mass. it is also useful for evaluating volume status based on resistance and reactance of cells known to have different electrical conductivity according to biological characteristics of body composition. in our previous study using bia, the results showed that changes in ecw ratio after surgery were related to conventional parameters of overhydrated status such as daily fluid balance or capillary leak index (cli). in addition, overhydration with value of ecw ratio above 0.390 on 3rd postoperative day appeared to be a risk factor for postoperative morbidity and mortality. herein, we aim to set the ecw ratio as a guideline for postoperative volume status and confirm a hypothesis that active intervention with fluid management to control the ecw ratio by bia could lower clinical outcomes in patients with fluid imbalance through a prospective randomized controlled study.

Eligibility criteria:
inclusion criteria: * patients admitted to the surgical icu after surgery under general anesthesia regardless of the type of surgery * patients who showed abnormal range of baseline ecw ratio by bia (less than 0.390 or more than 0.405) that measured at the time of icu admission exclusion criteria: * aged under 18 years * underwent surgery under local or regional anesthesia * pregnant * had bone fixation or underwent limb amputation * had any prosthetic medical devices such as pacemaker or metallic intravascular device * stayed in icu for less than 48 hours * readmitted within 48 hours after icu discharge * diagnosed with renal failure and receiving renal replacement therapy * underwent extracorporeal membrane oxygenation treatment before surgery * agreed for do-not-resuscitate
intensive care unit activity in france from the national database between 2013 and 2019

Conditions: Critical Illness; Intensive Care Unit

Summary: using data from the french national uniform hospital discharge database (systematically collecting administrative and medical information related to all hospitalized patients in france for care reimbursement purposes), the present study retrospectively assesses the activity of the french intensive care unit (icu)(1,594,801 icu admissions): * in-icu and in-hospital mortality rates * length of stay in icu and hospital * mortality-associated factors during the study period. * number of organ failures * bed occupancy, * regional variations in previous indicators


Eligibility criteria:
inclusion criteria: all adults patients admitted in french icu between january 1st, 2013, to december 31st, 2019
effects of a physical exercise and health education program for women with breast cancer undergoing chemotherapy

Conditions: Cancer, Breast

Summary: the purpose of this study is to verify the effect of the intervention of a program of physical exercises and health education in women with breast cancer undergoing chemotherapy.

according to the national cancer institute (inca), the estimate for brazil, 2016-2017 biennium, points to the occurrence of about 600,000 new cases of cancer, and breast cancer (58000) in women will be the most frequent. one study revealed that only 12% of women undergoing chemotherapy in cm who participated in a physical exercise program had to readjusted the dose of the medications, while 34% of those who received the conventional treatment needed to readjust the treatment doses, with neuropathy being one of the most present adverse effects that influenced this adjustment. in this sense, the conduct to keep the patient at rest during the treatment seems to potentiate her side effects, and sedentarism is another factor detrimental to the patient's health. objective: to verify the effect of the intervention of a program of physical exercises and health education in women with breast cancer undergoing chemotherapy. methodology: a sample will consist of 136 (136) women, over 18 years of age, sedentary, diagnosed with non-metastatic breast cancer and initiating the first cycle of chemotherapy. they will be divided into two groups, randomly and stratified: control group: (cg n = 68) and exercise group: (eg n = 68) that will undergo a supervised training program of combined exercises for 24 weeks, with a frequency of 3 times weekly and duration of 60 minutes, an unsupervised flexibility training program 2 times a week and both groups (gc and eg) will attend lectures on health education, which are held monthly.

Eligibility criteria:
inclusion criteria: * women over 18 years of age; * with the first diagnosis of non-metastatic breast cancer; * sedentary for 6 months; * who are in the initial cycle of chemotherapy; * with the release of the responsible physician; * availability to participate in the exercise program; * signing of the free and clarified consent term. exclusion criteria: * women with clinical risk for physical exercise (e.g. severe anemia, icc, cri); * pregnant women; * osteoarticular problems that preclude the practice of physical exercise.

Keywords: cancer physical exercise health education program
comparison of anorectal manometry and 3d manometry in diagnosis of functional disorders in children

Conditions: Constipation; Children; Fecal Incontinence

Summary: pressures measured by manometric solid-state catheters may differ according to the type of the catheter and specific anatomy and physiology of anorectum. the aim of the study is to establish the difference in recordings between 2 types of anorectal catheters used in pediatric patients and to validate the most appropriate way to diagnose of functional disorders.

patients enrolled in study will be investigated by both types of anorectal catheters, first by anorectal high resolution flexible, thinner, solid-state catheter and after that with rigid, thicker, solid-state catheter. both procedures will be undertaken during one session. there will be used standard protocol of the procedure that measures conventional manometric parameters (resting pressure, squeeze pressure, bear down manoeuver, thresholds of sensation and recto anal inhibitory reflex threshold.

Eligibility criteria:
inclusion criteria: * functional constipation * fecal incontinence * parental agreement exclusion criteria: * after surgery on lower gastrointestinal tract * diagnosis of inflammatory bowel disorders * diagnosis of other disorders present in anorectal area, that may influence anorectal pressures * lack of parental agreement

Keywords: manometry children constipation functional disorders
the longitudinal relationship of hu adherence to hrqol, barriers to adherence and habit in scd.

Conditions: Sickle Cell Disease; Sickle B+ Thalassemia; Sickle Beta Zero Thalassemia; Sickle Cell Hemoglobin C

Summary: the primary objective of this study is to better understand factors contributing to variations in hydroxyurea (hu) adherence behavior in adolescents and young adults (aya) with sickle cell disease (scd). to meet this objective, the researchers will conduct a prospective cohort study to determine the longitudinal relationship between hu adherence and health-related quality of life (hrqol) overtime among aya with scd. the long-term goal of this research is to promote medication adherence behavior and improve health outcomes in aya with scd.

sickle cell disease is the most common genetic disorder in the us, affecting about 100,000 americans, and about 1 in 400 african american live births, incurring annual health care costs of $335 million. scd can lead to serious complications including unpredictable, debilitating pain episodes, cardiopulmonary disease, stroke, and long-term end organ damage.these complications lead to significant declines in health-related quality of life (hrqol) and other patient-reported outcomes (pros), culminating in early mortality, particularly among aya. hydroxyurea, at present, is the main fda approved medication for scd that reduces morbidity and mortality, improves hrqol and lowers healthcare utilization.however, adherence to hu remains suboptimal with only 35-50% of patients achieving high adherence (≥90%), particularly among aya with scd. low hu adherence has been associated with worse health outcomes, poor hrqol and increased healthcare utilization. low hu adherence is multifactorial, especially in aya with other competing priorities and vulnerability in developmental and psychological factors contributing to adherence behavior. the specific aim for this study is to determine the longitudinal relationship of hu adherence behavior to health-related quality of life, barriers to adherence and habit formation among aya with scd.

Eligibility criteria:
inclusion criteria: * age 12-21 years old * any sickle cell disease genotype * on steady state of hydroxyurea for 2 months * own or have access to a smartphone * parents of patients that meet the eligibility criteria and are enrolled in the study will be included exclusion criteria: * patients with recent hospitalizations within the past 7 days

Keywords: sickle cell disease hydroxyurea
immun status at pancreatitis patients

Conditions: Pancreatitis; Immune Suppression

Summary: pancreatitis is a common complication especially in patients with gallbladder stones, most patients with biliary pancreatitis may recover spontaneously without sequelae, but in 10-20% of patients, the disease is severe and mortality rates of up to 30% are detected in these patients. in the evaluation of acute biliary pancreatitis, many scoring systems have been established (atlanta, ranson, apache, bisap etc.) from past to present to determine morbidity and mortality of the disease. in this study, the investigators aimed to evaluate the correlation between morbidity and mortality of acute biliary pancreatitis and serum proinflammatory cytokines with elisa and lymphocyte subtypes with flow-cytometry.

pancreatitis is a common complication especially in patients with gallbladder stones, most patients with biliary pancreatitis may recover spontaneously without sequelae, but in 10-20% of patients, the disease is severe and mortality rates of up to 30% are detected in these patients. in patients with severe pancreatitis, aggressive fluid replacement, organ damage follow-up, appropriate antibiotherapy, and endoscopic sphincterotomy and radiological interventions may be of great benefit. in the evaluation of acute biliary pancreatitis, many scoring systems have been established (atlanta, ranson, apache, bisap etc.) from past to present to determine morbidity and mortality of the disease. there are limited number of studies in the literature about the immune parameters in the evaluation of acute pancreatitis. in a studies, serum inflammatory markers such as il-1, il-6 and cd4, cd8 t lymphocyte and treg population were evaluated. it was reported that inflammatory markers, especially anti-inflammatory il-10 levels were elevated in patients with acute pancreatitis, and crp and il-1β levels of inflammatory markers were higher in patients with organ failure. treg cells are reported to be an independent prognostic factor in determining the severity of acute pancreatitis. there is only one study with a limited number of patients in whom pd-1 values in t lymphocytes and pd-l1 values in monocytes were determined in the literature. in this study, it is stated that pd-l1 can be used as a new marker in determining infectious complications. in patients diagnosed with acute biliary pancreatitis, determination of the course of the disease at the time of diagnosis is extremely important for treatment and survival. in this study, the investigators aimed to evaluate the correlation between morbidity and mortality of acute biliary pancreatitis and serum proinflammatory cytokines with elisa and lymphocyte subtypes with flow-cytometry.

Eligibility criteria:
inclusion criteria: * 18-80 years old * diagnosis of acute biliary pancreatitis * sign the voluntary consent form exclusion criteria: * being under 18 or older than 80 * not signing the voluntary consent form * pancreatitis resulting from an interventional procedure (ercp, surgery, etc.) * pregnant women * being a history of immunodeficiency * cancer history

Keywords: pancreatitis lymphocyte subtypes cytokine
kangaroo mother care with plastic bag (trials 2a & 2b)

Conditions: Preterm Infant; Hypothermia Neonatal

Summary: the purpose of this study is to determine whether the combination of kangaroo mother care (kmc) as continuously as possible together with the use of a plastic bag in combination with routine world health organization (who) thermoregulation care reduces the incidence of moderate (32-36° c) or severe (\<32.0° c) hypothermia in term infants ≥ 37 0/7 weeks of gestational age (ga) when compared to kmc as continuously as possible together with routine who thermoregulation care.

the purpose of this study is to determine whether the combination of kangaroo mother care (kmc) as continuously as possible together with the use of a plastic bag in combination with routine world health organization (who) thermoregulation care (warm delivery rooms, immediate drying after birth, early and exclusive breastfeeding, postponement of bathing and weighing, and appropriate bundling) reduces the incidence of moderate hypothermia (32-36° c) or severe (\<32.0° c) in term infants ≥ 37 0/7 weeks of gestational age (ga) when compared to kmc as continuously as possible together with routine who thermoregulation care, as practiced. the investigators are proposing two trials, one protocol for infants 32-36 6/7 weeks and one for infants who are ≥37 weeks gestational age (this one). this term infant trial will address the effectiveness of kmc in combination with plastic bags in decreasing hypothermia in preterm infants. the proposed trial will determine whether kmc with plastic bags prevents hypothermia in neonates born in a healthcare setting with limited resources where a high risk for hypothermia has been reported. any intervention that decreases morbidity during the neonatal period has the potential to impact health beyond the neonatal period,and one that is highly cost-effective and easy to use is more likely to be implemented in the developing world.

Eligibility criteria:
inclusion criteria: * estimated gestational age ≥37 0/7 weeks * delivery in the hospital exclusion criteria: * abdominal wall defect or myelomeningocele * major congenital anomalies * blistering skin disorder * clinically unstable mothers secondary to cardiovascular and pulmonary conditions * infants requiring respiratory support beyond 10 minutes after birth * infant requiring neonatal intensive care unit admission * cesarean section * multiple gestation if the last delivering infant is not born within 10 minutes from the time of birth of the first infant

Keywords: infant newborn preterm hypothermia kangaroo plastic bag