Kornimate/medical-research-clean huggingface dataset:
bone health management for women diagnosed with breast cancer

Conditions: Osteoporosis; Breast Cancer

Summary: the purpose of this study is to test the feasibility of the study protocol. the study protocol was designed to evaluate questions - "do educational materials improve dual x-ray absorptiometry (dxa) screening rates for women diagnosed with breast cancer" and "does educational materials delivered by the participant's selected choice change dxa screening rates compared to the conventional mail method?".

"bone health management" for osteoporosis is important for women diagnosed with breast cancer. osteoporosis can lead to bones breaking easily. broken bones may make living independently challenging. effective bone health management can reduce the risk of broken bones. this study will examine whether providing "osteoporosis information" to women diagnosed with breast cancer will promote their bone health management. with the current advance in technology, people are more interested in receiving information by email or smartphone text messaging. this study will also examine whether delivering osteoporosis information in different ways will change bone health management.

Eligibility criteria:
inclusion criteria: * women * is 65-75 year old on july 1st, 2015 * lives in british columbia (bc), canada * reads and understands the information provided in english * was diagnosed with breast cancer prior to july 1st, 2012 * is not receiving surgery, radiation or chemotherapy for any cancers * has not had breast cancer spread beyond her breast(s) and nearby lymph nodes * has not had screening tests after july 1st, 2012 * is not taking medications prescribed by doctors for osteoporosis exclusion criteria: * is medically unfit for preventive care (death, cognitive impairment, nursing home admission, severe mental illness, etc), which will be determined by their family doctors * have terminated patient-doctor relationship with her family doctor who is indicated in our record

Keywords: osteoporosis dxa screening women breast cancer survivors educational materials personal choices on delivery methods
validation of an algorithm to predict the ventilatory threshold

Conditions: Cardiovascular Diseases

Summary: the aim of the current study was to develop an algorithm which has the ability to accurately predict the first and second ventilatory threshold and in cardiovascular disease patients and to guide in proper exercise intensity determination. this would then help, at least in part, to overcome the lack of access to metabolic carts or cardiopulmonary exercise test, and/or methodological difficulties with ventilatory threshold determination in these patients.

design this study is composed out of two sub studies: 1. generation/creation of vt prediction algorithm, and 2. validation of this algorithm in independent laboratories. sub study 1: generation/creation of vt prediction algorithm from april 2015 up to july 2020, data from cvd (risk) patients (e.g. obesity, diabetes, coronary artery disease or heart failure) were collected from in light of research studies. all participants signed an informed consent explaining the nature and risks of cpet, and allowing us to use anonymized data for the analyses of their cpet at entry of cardiovascular rehabilitation or an exercise intervention. these data have been published in previous publications. sub study 2: validation of the algorithm in independent laboratories from april 2015 up to july 2020, data from cvd (risk) patients (e.g. obesity, diabetes, coronary artery disease or heart failure) were collected in light of research studies. all participants signed an informed consent (approved by the ethics committees of the local hospitals or research laboratories) explaining the nature and risks of cpet, and allowing us to use anonymized data for the analyses of their cpet at entry of cr or an exercise intervention. these data have been published in previous publications

Eligibility criteria:
inclusion criteria: * cvd patients (eg obesity, diabetes, coronary heart disease, heart failure) exclusion criteria: * no present cvd
effects of therapeutic exercises in elderly women with knee osteoarthritis

Conditions: Osteoarthritis

Summary: knee osteoarthritis is a degenerative disease associated with muscle weakness, arthralgia, rigidity and postural instability. therapeutic exercise can reduce pain and improve muscle strength and postural balance, however benefits from association with pompage is not known. this study aims to evaluate the effects of therapeutic exercise on pain, muscle strength and postural balance in elderly women with knee osteoarthritis. methodology: almost randomized controlled trial, in which were included elderly between 60 and 80 years diagnosed with knee osteoarthritis, randomized into two groups with 11 participants each. intervention group held strengthening exercises for flexors and knee extensors, balance training, and manual knee pompage for 12 weeks. control group received educational lectures. arthralgia was estimated by pain subscale of the questionnaire western ontario mcmaster universities osteoarthritis index and (womac); muscle strength was assessed by the isokinetic dynamometer humac® norm testing \& rehabilitation system and the postural balance by the biodex balance sd postural stability protocol (biodex medical systems, inc. new york, usa). the student t test was used for statistical analysis.


Eligibility criteria:
inclusion criteria: * female * aged between 60 and 80 years * diagnosed with knee's osteoarthritis according to clinical and radiographic criteria of the american college of rheumatology. exclusion criteria: * cardiovascular and/or unstable respiratory diseases * knee or hip arthroplasty; in the last 6 months: surgery on lower limbs, intraarticular corticosteroid injection in the knee, physical therapy * associated diseases that contribute to the balance disorders (for example ankylosing spondylitis, rheumatoid arthritis, diabetes mellitus, neurological diseases, parkinson's disease, cerebral palsy and vestibular).

Keywords: osteoarthritis therapeutic exercises pain muscle strength postural balance
biobank of samples from patients with infectious diseases

Conditions: Infectious Diseases

Summary: the aim of the infectiotek biobank will be to prospectively build a biobank of multiple biological samples from patients with infectious diseases in order to identify diagnostic and prognostic biomarkers, genetic susceptibility factors and immune response mechanisms in such diseases. the population of the study will consist of patients treated in the infectious diseases departments of saint-louis and lariboisière hospitals, with a diagnosis of infectious disease, and who have biological samples in the context of their routine medical care. the diseases studied in this research project are bacterial infections (urinary tract infections, neurologic infections, sexually transmitted infections, pulmonary infections), viral infections (hiv, hepatitis, respiratory viruses, viruses affecting immunocompromised patients) and fungal infections (aspergillus, mucorales, cryptococcus). these diseases are the domains of expertise and research of the clinical and biological teams at the saint-louis and lariboisière hospitals.


Eligibility criteria:
inclusion criteria: * patient over 18 years of age * diagnosed with one of the following infectious diseases : * infection with hiv-1 or hiv-2, or person at risk of infection with hiv * viral hepatitis (hav, hbv, hcv, hdv, hev) * pulmonary infections: bacterial (notably nocardia), viral (influenza, rsv, sars-cov-2, adenovirus), fungal (aspergillus, mucorales) * urinary tract infections * sexually transmitted infections (neisseria gonorrheae, chlamydia trachomatis, mycoplasma genitalium, treponema pallidum) * neuromeningeal infections: (neisseria meningitidis, streptococcus pneumoniae), viral (hsv, vzv), fungal (cryptococcus). * infections affecting immunocompromised patients: herpes viruses (hsv, vzv, cmv, ebv), polyomavirus bk * emerging pathogen x (in the event of an epidemic) * signature of research consent form * health coverage with social security system or state medical aid exclusion criteria: * refusal to participate * inability to give consent (cognitive impairment etc...)

Keywords: biobank bacterial, viral and fungal diseases
adherence evaluation in copd

Conditions: Adherence, Treatment; COPD

Summary: the rationale of this study is to have a better understanding of the perception of the pulmonologists, general practitioners and patients of adherence (causes, main consequences, supportive tools,..) and the use of tai-questionnaire (appreciation, usability,...) by interviewing pulmonologists \& general practitioners and a survey with patients. based on the outcome, projects and tools can be developed to help health care professionals to motivate patients to improve adherence and to help patients to increase their adherence to inhalation therapy.


Eligibility criteria:
inclusion criteria: pulmonologists or general practitioners or copd patient (suffering from copd treated with inhalation therapy) exclusion criteria: not applicable
the effects of preoperative prayer on postoperative quality of recovery in patients undergoing thyroidectomy

Conditions: Thyroid Cancer

Summary: physiological end-point, incidence of adverse events, and changes in psychological status. in the past, physiological goals, major morbidity and mortality were used as indicators of recovery after surgery. however, major morbidity and mortality rates were extremely low due to the development of surgery and anesthesia techniques, and measurements of these indicators do not adequately reflect postoperative recovery. on the other hand, the measurement of the patient's health status or quality of life has become an important metric in many clinical studies. the quality of recovery 40 questionnaire (qor-40) is a multidimensional tool that specifically assesses and develops anesthetic and postoperative health conditions. severance hospital is conducting an anesthesiologist-led prayer for the patient only for the desired patient before anesthesia. although it may be expected that this preoperative airway may improve the quality of recovery after anesthesia / surgery by reducing patient anxiety, there is no objective study on this. the aim of this study was to investigate the effect of preoperative preoperative airway on the quality of postoperative recovery in patients who underwent thyroidectomy for thyroid cancer. i want to see. in addition, we will investigate whether preoperative airway affects sympathetic nervous system during surgery.


Eligibility criteria:
inclusion criteria: * patients between 20 and 70 years old under asa 3. * obtaining written informed consent from the patients who were undergoing thyroidectomy. * weights under 90 kg and bmi under 30 exclusion criteria: * emergency operation * re-operation * combined surgery over 4 departments * cardiac disease (unstable angina, congestive heart failure, valvular heart disease) * ventricular conduction abnormality * prior pacemaker insertion * uncontrolled hypertension (diastolic blood pressure \> 110mmhg) * bradycardia (hr \< 40 bpm) * cerebral vascular disease (cerebral hemorrhage, cerebral ischemia) * hepatic or renal failure * patients who take antiarrythmic agent * neurological or psychiatric illnesses * foreigner and patient who can not read the letter

Keywords: quality of recovery 40 questionaries
clinical, genetic and environmental determinants of prostate cancer progression.

Conditions: Prostatic Neoplasm; Adenocarcinoma; Neoplasm Recurrence; Neoplasm Metastasis

Summary: the course and progression of prostate cancer is highly variable, depending on the individual characteristics, the aggressiveness of the disease at the time of diagnosis as well as the ethno-geographic origins of the individuals. the general objective of the project is to identify the clinical, genetic and environmental determinants (risk factors) of the evolution, progression and complications of the disease according to the treatment options. identifying modifiable and non-modifiable prognostic determinants of disease progression is a major challenge. this knowledge will help guide treatment choices but also, especially in high-risk populations (high incidence of disease) to better tailor prevention policies and possibly screening .

there is a lack of information to predict the course of prostate cancer following its initial diagnosis; in other words, why some are indolent and evolve very slowly and others are aggressive, evolve rapidly with an increased risk of metastasis development and death. in addition, these evolutions do not seem similar according to ethno-geographic origins. we therefore hypothesize that in addition to genetic susceptibility factors specific to individuals and / or linked to their ethno-geographic origins, medical, occupational and environmental factors can influence the course of the disease and the response to treatments. we will build two prospective cohorts of incident cases of prostate cancer, one in guadeloupe (whose population is predominantly afro-descendant) and one in rennes (brittany, whose population is mainly of caucasian origin). each patient will be subject to longitudinal follow-up over time. structured questionnaires will be administered at the time of diagnosis and at regular times after the initial treatment or subsequent treatments. they will focus on socio-demographic data, places of residence, education levels, lifestyles (tobacco, alcohol), personal and family medical history, current treatments, current and past occupational activities. anthropometric and blood pressure measurements will be made at the time of diagnosis and at regular times after treatment. saliva, urine and blood samples will be obtained. clinical data related to the disease will be collected continuously.

Eligibility criteria:
inclusion criteria: inclusion criteria: adult patients with incident case of prostate cancer patient consulting the university hospital of guadeloupe or the university hospital of rennes patient who resides in the departments of guadeloupe or martinique or the community of saint-martin or in britany patient affiliated or beneficiary of the social security signed consent exclusion criteria: physical or mental health judjed by the investigator as precluding participation in the research protected adults (guardianship, curatorship, safeguard of justice).
unmet needs of axial spondyloarthrits in egyptian patients

Conditions: Axial Spondyloarthritis

Summary: during the past decade, the well-known disease called ankylosing spondylitis has come to be considered as a subset of the broader entity referred as axial spondyloarthritis (axspa), which also includes non-radiographic axspa. the need of this new classification was aimed to improve the sensitivity for an early diagnosis, to reduce diagnostic delay, and to allow an early treatment. although there is improvement in the recognition, the management of patients, and the treatment strategies of axspa, unmet needs persist , there is still a substantial gap of 5-8 years between the onset of symptoms and the diagnosis of axspa. . this study is intended to enhance awareness and understanding of axial spondyloarthritis and to identify and discuss the current unmet needs in axspa . multiple defects are still unfullfilled for axial spa patients those defects include delayed diagnosis specially for female, failure to acheive treatment target, pain, impaired quality of life and associated comorbidities. up to the best of our knowledge this is the first study to highlight unmet needs for axial spondyloarthritis patients in egypt in general and in upper egypt in particular .


Eligibility criteria:
inclusion criteria * patients fulfill the assessment in spondyloarthrits international society (asas) classification criteria for axial spondyloarthritis . * age above 16 years old. * patient cooperative and can answer questions . exclusion criteria: * other rheumatologic or collagen diseases . * age below 16 years and above 60 years. * uncooperative patients .
normal saline vs hypertonic saline in the treatment of bronchiolitis

Conditions: Length of Hospital Stay

Summary: background: bronchiolitis is one of the most common and costly respiratory diseases in infants and young children. despite the high prevalence and morbidity of bronchiolitis, therapy remains controversial. supportive care ensuring adequate hydration and oxygenation remains the cornerstone of therapy for these infants. over the past 2 decades, research on bronchiolitis management has explored the use of nebulized hypertonic saline that rehydrate the airway surface liquid and improve mucociliary clearance, as well as reduce airway edema. aim:the aim of this study is to investigate whether the addition of frequently nebulized hypertonic saline to standard therapy affects the length of stay (los) of moderately ill infants hospitalized with bronchiolitis.

the investigators will conduct this prospective double blind randomized clinical trial by comparing between 2 groups of patients with bronchiolitis, first group will receive 3% hypertonic saline and second group will receive 0.9% saline. data collection includes: name, age, mode of delivery, birth weight, current weight, number of sibling, immunization record, duration of breast feeding, past medical history including number of wheezy chest, pneumonia, parents level of education, presence of asthma / allergic rhinitis in family, pets /smoke at home) using the validated respiratory distress assessment instrument (rdai) investigators will assign patients a score before and at the end of treatment. to prepare 3% sodium chloride, the investigators will dilute 60 ml 20% sodium chloride injection with 500 ml normal saline (nss) 0.9%. length of stay will be measured in both groups, to establish the efficacy of hypertonic saline in reducing length of stay.

Eligibility criteria:
inclusion criteria: * infants up to 24 months of age with diagnosis of acute bronchiolitis * in accordance with 2006 american academy of pediatrics (aap) definition of bronchiolitis,we did not limit to the first episode of wheeze * patients with the diagnosis of bronchiolitis exclusion criteria: * chronic lung or heart disease (hemodynamically significant cardiac disease, chronic lung disease / bronchopulmonary dysplasia requiring diuretics or oxygen) * cystic fibrosis, trisomy 21, immunodeficiency / transplant recipient, neuromuscular disease
study to evaluate the lot to lot consistency of siipl meningococcal acywx conjugate vaccine and to compare its safety and immunogenicity with that of licensed meningococcal acwy vaccine menactra® in healthy individuals 18-85 years of age

Conditions: Vaccine for Meningococcal Disease

Summary: this is a phase 2/3, randomized, observer blind, multi-centre, controlled study to evaluate the safety, immune response and consistency of immune response of three consecutively manufactured lots of nmcv-5 in healthy individuals between the ages of 18 to 85 years (both inclusive). the immune response of nmcv-5 will also be statistically compared against a licensed conjugate vaccine against acyw (menactra). a total of 1640 subjects 18 to 85 years of age will be accrued contemporaneously across three age groups - 18 to 29 years, 30 to 60 years, and 61 to 85 years. within each age group subjects will be randomly assigned in a 3:1 ratio to receive either nmcv-5 or menactra. the nmcv-5 subjects in 18-29 year age group will be further randomized 1:1:1 into three different lots (lot a, b \& c) of nmcv-5. all the randomized subjects will receive a single dose of 0.5 ml of nmcv-5 or menactra on day 1. post vaccination site visits are planned on days 8, 29 and 180 and a telephonic call at day 85.


Eligibility criteria:
inclusion criteria: 1. male or non-pregnant female 18 through 85 years of age, both inclusive, at the time of study vaccine administration. 2. provide written informed consent. 3. the subject is resident of the study area and is willing to comply with study protocol requirements, including availability for all scheduled visits of the study. 4. healthy, as determined by medical history and clinical assessment of the investigator. 5. female subjects of childbearing potential must have a negative urine pregnancy test within 24 hours prior to study vaccine administration. exclusion criteria: 1. acute illness, at the time of study vaccine administration (once acute illness is resolved, if appropriate, as per investigator assessment, subject will be re-revaluated for eligibility). 2. history of any meningococcal vaccine administration. 3. current or previous, confirmed or suspected disease caused by n. meningitidis. 4. household contact with and/or intimate exposure to an individual with any laboratory confirmed n. meningitidis infection within 90 days prior to vaccination. 5. history of severe allergic reactions after previous vaccinations or hypersensitivity to any study vaccine component including tetanus, diphtheria and diphtheria toxoid (crm197).
a phase i/ii clinical study of shr-1681 for injection in patients with advanced solid tumors

Conditions: Malignant Solid Tumors

Summary: this study is an open-label, multicenter phase i/ii clinical trial to evaluate the safety, tolerability, pharmacokinetics and efficacy of shr-1681 for injection in patients with advanced solid tumors.


Eligibility criteria:
inclusion criteria: 1. subjects must voluntarily agree to participate in the trial and sign a written informed consent form; 2. subjects with histologically or cytologically confirmed unresectable locally advanced or metastatic solid tumors which is relapsed or refractory to standard treatment, or lack of standard treatment, or standard treatment is not applicable currently; 3. have at least one measurable tumor lesion per recist v1.1; 4. ecog performance score of 0-1; 5. life expectancy ≥ 3 months; 6. adequate bone marrow and organ function. exclusion criteria: 1. subjects with active central nervous system metastases or meningeal metastases; 2. history of serious cardiovascular and cerebrovascular diseases; 3. subjects with a history of interstitial pneumonitis or imaging at screening suggestive of suspected interstitial pneumonitis; 4. severe infection within 4 weeks prior to the first dose; 5. ongoing or previous anti-tumor therapies within 4 weeks prior to the first dose of study drug; 6. adverse reactions of previous anti-tumor treatment have not recovered to grade ≤ 1 per nci-ctcae v5.0.
keeping it simple - implementing pain education for all

Conditions: Chronic Pain

Summary: pain education has proven difficult to implement into clinical practice. in denmark 4 out of 10 adults has inadequate health literacy levels. to avoid inequality in health care we need a new and accurate method to provide pain education to all who need it. in this study, existing concept of pain education is implemented into clinical practice for a group of chronic pain patients including those with low degrees of health literacy, and then evaluate its use from both patient and physiotherapist perspective.

the focus of this is project is to implement existing knowledge into clinical practice and to adapt and test a tool (i.e., pne4kids) that was initially developed to explain pain to children and their parents, for its potential to teach adults in pain about contemporary pain science in a way that takes into consideration those with low degrees of health literacy. further, we want to test its feasibility in adult pain patients at a community-based rehabilitation center. it is expected that adult patients suffering from chronic pain will find the adapted pne4kids, named pne4adults, comprehendible, will benefit from this type of pain education in terms of increased pain knowledge and self-efficacy, and decreased pain-intensity and pain catastrophizing thoughts. it is also expected that physiotherapists will find the pain education program easy to engage with and to transfer into a clinical setting.

Eligibility criteria:
eligible patients are; danish speaking adult patients (≥18 years) patients with chronic musculoskeletal pain (pain ≥ 3 months).