Kornimate/medical-research-clean huggingface dataset:
predictors of response to treatment for depression

Conditions: Adolescent Depression; Depression

Summary: the current study will examine neurophysiological, specifically event-related potential (erp), measures of emotional processing as predictors of response to cognitive behavior therapy for adolescent depression.

neurophysiological measures (i.e., event-related potentials) of reward responsiveness and regulation of mood-congruent, sad stimuli will be assessed in a sample of adolescents with depression prior to group cognitive behavior therapy (cbt). cbt will follow the adolescent coping with depression course, an established 16-session group treatment protocol, and consist of behavioral activation, relaxation skills, cognitive therapy, social skills, problem solving, and relapse prevention. changes in symptoms will be monitored through biweekly self-report and clinician ratings to examine prediction of change in symptoms across cbt. baseline individual differences in reward responsiveness and emotion regulation will be evaluated as predictors of change in self-reported symptoms and clinician-rated improvement following cbt.

Eligibility criteria:
inclusion criteria: * participants presenting with major depressive or persistent depressive disorder and moderate severity on the clinical global impressions scale. * participants may have comorbid externalizing or anxiety disorders. * participants (and parents of minors) fluent in english. exclusion criteria: * youth with history of treatment for substance use disorders. * youth with intellectual or developmental disabilities (e.g., autism spectrum disorders, pervasive developmental disorders). * youth with lifetime schizophrenia, psychosis, or mania. * youth with severe current suicidality. * youth taking antipsychotic medications or mood stabilizers. * youth with recent changes in dosage of antidepressant (adolescents with change in dosage in past 30 days who otherwise meet study criteria will be asked to begin the study once dosage has been stable for 30 days). * parent or child not fluent in english. * youth who are unable to complete study procedures because of visual or hearing impairments. * youth who have recently started outside therapy (past 30 days at time of intake), are engaged in treatment that is determined to be too similar to study therapy (e.g, other cbt groups), or are currently in treatment that is too intensive to allow for participation in study therapy (e.g., partial hospitalization programs)

Keywords: reward emotion regulation electroencephalogram event-related potentials cognitive behavior therapy
efficacy and safety assessment of azyter® eye drops (t1225) in patients with blepharitis

Conditions: Blepharitis

Summary: the primary objective of this study is to demonstrate the efficacy of t1225 eye drops versus placebo eye drops on the global ocular discomfort (vas).

currently, topical antibiotic ointments are used for blepharitis. they provide prolonged contact time with the lid margin but with little penetration into eyelid tissue. azithromycin eye drops may offer on advantage over these preparations because azithromycin achieves sustained high concentration in various ocular tissues including the lid margin. patients will be treated during 7 days (1 drop twice daily the first day following by one drop once daily for 6 days) following by a period of 2 weeks without treatment. this therapeutic scheme will be repeated two times. efficacy will be evaluated by change from baseline (day 0) to day 63 â± 3 days of the global ocular discomfort evaluation (vas).

Eligibility criteria:
inclusion criteria: -diagnosis of moderate to severe chronic blepharitis (posterior and/or anterior) in at least one eligible eye exclusion criteria: * monophtalmia * eyelid dysfunction * facial paralysis. * severe dry eye syndrome. * ocular metaplasia. * filamentous keratitis * schirmer test \< 5 mm. * best far corrected visual acuity \< 1/10.

Keywords: azyter in patients affected by chronic blepharitis.
reasons for non-reversal of temporary stomas after surgeries of mid-low rectal cancer （noresto study）

Conditions: Rectal Cancer

Summary: the goal of this observational study is to learn about in mid-low rectal patients who received temporary ostomies after surgery of the primary tumors. the main questions it aims to answer are: * to explore the proportion of temporary stomas that cannot be reversed after radical surgery for mid-low rectal cancer and their main causes. * to use the basic information we collected from patients before and during surgery to develop an individualized model for predicting the time of stoma reversal and explore the risk factors affecting stoma reversal.


Eligibility criteria:
inclusion criteria: * pathologically confirmed as rectal adenocarcinoma; * the tumor is located within 12cm from the anal verge; * primary tumor is radically resected; * the patient received a temporary ostomy during the in-hospital visit of the resection of the primary tumor. exclusion criteria: * the stoma was initially recognized as permanent stoma; * patients with distant metastasis; * patients with multi-primary colorectal cancer.
active surveillance for low-risk prostate cancer - evaluation of the efficacy of minimally invasive active surveillance

Conditions: Prostate Cancer

Summary: the sthlm3-as study will evaluate the specificity of a new proposed protocol for active surveillance using the stockholm3 test in combination with mri targeted biopsies for prostate cancer detection in men with diagnosed low-risk prostate cancer undergoing active surveillance in comparison to conventional follow up using psa and systematic biopsies.

the study design is a cross-sectional study, using a paired design, evaluating our proposed protocol (stockholm3+mri+targeted biopsies) versus the standard protocol (psa+systematic biopsies). men from the sthlm3 study, diagnosed with low risk prostate cancer and currently on as will be invited to the study. eligible individuals have to be alive without any severe comorbidity and without a history of initiating treatment; surgery, radiation, hormone therapy or chemotherapy. to avoid the need for additional biopsies, invitation will be synchronized with timing for planned follow-up within the as program for each individual. at baseline blood will be drawn for psa and stockholm3 analyses. the patient will be asked to fill out a study specific questionnaire with questions on anxiety and quality of life. additionally, a bi-parametric mri evaluated in line with pi-rads v2 guidelines will be performed. for men with pirads ≥ 3 targeted and systematic biopsies will be performed. for men with pirads\<3 only systematic biopsies will be performed. main outcome measurement will be number of detected significant cancers by each method. further outcome measurements are the number of performed prostate biopsies with each method and level of anxiety and quality of life.

Eligibility criteria:
inclusion criteria: * men in the sthlm3 study, diagnosed with a low risk prostate cancer and on as exclusion criteria: * history of treatment for prostate cancer; surgery, radiation, chemotherapy or hormonal treatment. * severe illnesses such as metastatic cancers, severe cardio-vascular disease or dementia * contraindications for magnetic resonance imaging (mri) e.g. pacemaker, magnetic cerebral clips, cochlear implants or severe claustrophobia.

Keywords: active surveillance
selective bilateral laryngeal reinnervation as a secondary treatment in case of bilateral vocal fold paralysis

Conditions: Bilateral Vocal Fold Paralysis

Summary: selective laryngeal bilateral reinnervation as a secondary treatment in patients with bilateral vocal fold paralysis, previously treated by endoscopy, without residual arytenoids ankylosis. the surgical procedure is : functional reinnervation with the upper root of one phrenic nerve, is used for reinnervation of both cricoarytenoid muscles (laryngeal inspiratory muscles), and simultaneous reinnervation of adductor laryngeal muscles is performed by right and left thyro -hyoid nerves (coming from the hypoglossi) on both sides. results are obtained after 6 to 9 months delay. in case of good inspiratory arytenoid abduction, and residual dysphonia, a secondary vocal fold medialization is done by an endoscopic approach 12 months after reinnervation (included in the protocol). improvement is expected in voice and breathing, without aspiration.


Eligibility criteria:
inclusion criteria: * patient with bilateral vocal fold paralysis in a closure position 6 months to 36 months before. * patient who has been treated by endoscopic treatment without satisfying result (voice or breathing). * patient with passive mobile arytenoid at least on one side * tracheostomized or not * age \> 18 years old * good general situation exclusion criteria: * long term vocal fold paralysis (more than 3 years with strong denervation) * ary-cricoid ankylosis or synechiae * age \>75 years * anaesthesiologist contra indication * strong respiratory disease history * severe coagulation troubles * ongoing neoplasia disease * cardiac pace maker * pregnant woman or without contraception * impairment of the freedom
effectiveness of lateral wedge insole on knee osteoarthritis outcomes in pakistani population

Conditions: Medial Compartment Knee Osteoarthritis

Summary: osteoarthritis (oa) is a persistent joint disorder, which normally affects the weight bearing joints especially knee joint. lateral wedge insole is one such approach suggested by professionals to manage the knee osteoarthritis.effectiveness of lateral wedge insoles (lwi) group (n=20), and conventional physical therapy (cpt) group (n=20) with home exercises as baseline treatment were assessed on urdu version of knee injury and osteoarthritis outcome score scale (koos).

a total of n=104 patients were recruited through the non-probability convenience sampling technique and were thus evaluated for the inclusion criteria. of which, n=40 participants fulfilled the inclusion criteria. participants were randomly divided through the sealed envelope method in two groups; lateral wedge insoles with home exercises group (n=20), and traditional physiotherapy with home exercises group (n=20). the data was collected through a general demographic questionnaire and knee injury and osteoarthritis outcome score (koos) in urdu to determine the severity of pain, stiffness, functional activities, recreational activities and quality of life to promote functional independence in osteoarthritic patients.\[20\] the level of significance was set at p\<0.05. statistical package for the social sciences (spss) ver. 23 was used for data analysis.as the assumption of the parametric test was met, mixed anova was used for the interaction effect of between-subject factor (group) and within-subject factor (time). with-in group analysis and one way anova was used for between-group comparisons to determine the effect size (ɳp2).

Eligibility criteria:
inclusion criteria: * patients with the age criteria of 40-70 years, and who had a history of knee oa were included in the study. exclusion criteria: * patients had knee oa due to trauma or any pathology, multiple fractures, or had a medical condition due to which rehabilitation wasn't possible, and not willing to participate in the clinical trials were excluded from the study.

Keywords: knee osteoarthritis, functional independence, musculoskeletal physiotherapy, orthotics, quality of life.
single vs double symphyseal plating in management of vertically unstable open book pelvic ring injuries:

Conditions: Evaluation of Single Symphyseal Plating in APC III Injuries

Summary: compare functional, radiological outcomes, implant failure and the incidence of recurrent diastasis of single superior symphyseal plate versus double plating in management of vertically unstable open book injuries

the real algorithm was the necessity for double superior \& anterior plating versus single superior symphyseal plate in management of apc iii pelvic ring injuries, whether the incidence of intraoperative and short-term postoperative complications, recurrent diastasis, radiological and functional outcomes differed between these two methods. our hypothesis was that the use of an additional anterior symphyseal plating could provide a more rigid fixation, with less complications of recurrent diastasis or implant failure. also it will be applied through the same incision without increasing the patient overall morbidity.

Eligibility criteria:
inclusion criteria: * anterior ring symphyses diastasis * tile c pelvic ring injuries * age between 16-60 years' old exclusion criteria: * tile b pelvic ring injuries * isolated bony fractures of the anterior pelvic ring * open fractures * age less than 14 years and older than 60 years * associated internal organ injuries that require definitive intervention

Keywords: apc iii pelvic ring injuries single symphyseal plating double symphyseal plating functional outcome majeed pelvic score
efficacy and safety of everolimus in combination with cyclosporine microemulsion versus everolimus in combination with enteric-coated mycophenolate sodium (ec-mps), in adult renal transplant patients in maintenance.

Conditions: Renal Transplantation

Summary: efficacy and safety of 2 groups of treatment: everolimus in association with cyclosporine microemulsion and steroids versus everolimus in association with enteric-coated mycophenolate sodium (ec-mps) and steroids. the study population consists of patients having taken part in study crad001a2420 (nct00154297) until the end (12 months) and having not prematurely discontinued the immunosuppressive regimen received in this study (everolimus + cyclosporine microemulsion + steroids).


Eligibility criteria:
inclusion criteria: * patients who participated in and completed study crad001a2420 exclusion criteria: * premature study or study treatment discontinuation in crad001a2420 study. * acute rejection within the 3 months prior to inclusion other protocol-defined inclusion/exclusion criteria may apply

Keywords: everolimus, calcineurine inhibitor, renal transplantation in maintenance, chronic allograft nephropathy
diet quality, pecans, and cardiometabolic health

Conditions: Cardiovascular Diseases

Summary: a three-period, randomized, crossover controlled feeding trial will be conducted to examine the effect of including 2 oz./day of pecans, as a snack, in a diet representative of average american intake, compared to a diet representative of average american intake devoid of nuts, and a healthy dietary pattern including 2 oz./day of pecans on markers of peripheral vascular health, lipids and lipoproteins, blood pressure, and glycemic control.

participants will be randomized to each diet for 4-weeks with a minimum 2-week break between the diet periods. all caloric foods and beverages will be provided. outcome assessments will be done at baseline and the end of each diet period.

Eligibility criteria:
inclusion criteria: * bmi ≥25 and ≤40 kg/m2 * ≥ 1 criterion for metabolic syndrome (i.e. waist circumference ≥ 94 cm men or ≥80 cm women; triglycerides ≥150 mg/dl; hdl ≤ 40 mg/dl men or ≤50 mg/dl women; systolic blood pressure ≥130 mmhg or diastolic blood pressure ≥85 mmhg; fasting plasma glucose ≥100 mg/dl) at screening. * non-smoking exclusion criteria: * current tobacco use or use within the previous 6 months * diagnosed diabetes or fasting glucose levels \> 126 mg/dl at screening * systolic blood pressure \>160 mm hg or diastolic blood pressure \> 100 mm hg at screening. * use of anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics in the previous month * history of a cardiovascular event (heart attack, revascularization, stroke), or heart failure, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis * use of supplements and botanicals known to affect study outcomes (e.g. psyllium, fish oil, soy lecithin, and phytoestrogens) and not willing to cease for the duration of the study * pregnancy, lactation or planning to become pregnant * consumption of \>14 alcoholic drinks/week * intolerance/allergy/sensitivity to foods included in the study menus
effectiveness of rotavirus immunization in nicaragua

Conditions: Diarrhea

Summary: the purpose of the investigators study is to compare the rates of childhood diarrhea at the community level before and after the rotavirus vaccination program in león, nicaragua. from preliminary studies, the investigators anticipate about a 28% reduction in diarrhea following the vaccination program among children who received the vaccine, and a smaller reduction in diarrhea among children who did not receive the vaccine, due to the effects of "herd immunity". in addition, the investigators will collect stool samples from children who develop diarrhea in order determine the etiology of childhood diarrhea in the post-rotavirus immunization era.


Eligibility criteria:
inclusion criteria: * age under 5 years, inclusion in health and demographic surveillance system (cids) in leon, nicaragua exclusion criteria: * parents do not consent to child's participation

Keywords: diarrhea childhood rotavirus vaccine nicaragua
multiple system atrophy multidisciplinary clinic

Conditions: Multiple System Atrophy (MSA)

Summary: this is a prospective cohort study to examine the disease burden of multiple system atrophy and the impact of multidisciplinary care on quality of life and caregiver burden. data will be collected through valid rating scales completed by patients and caregivers at home or in the msa clinic.

study procedures: participants and caregivers will attend a multidisciplinary msa clinic one day every four months. in addition to the standard of care, they will be asked to complete both online and paper questionnaires, including the following: * umsars (unified msa rating scale) * msa qol * ces-d * ohq * compass-31 * bic * updrs * sara * mds scale * cgi * moca participants will be part of the study as long as they are a patient of the msa clinic, and will be contacted for follow-up information up to five years.

Eligibility criteria:
inclusion criteria: * subject must be a patient in the ut southwestern msa clinic and be able to attend the multidisciplinary clinic every 4 months * patients with possible or probable msa based on established criteria * subjects must be 18 years or older exclusion criteria: * patients that are unable to give consent * minor patients (younger than age 18) * non-english speaking patients * subjects that are diagnosed with dementia
geriatric syndrome in nursing home residents

Conditions: Disability Physical

Summary: disability in daily living activities (adl) is a typical issue among nursing care residents. the goal of this study was to look at the geriatric syndromes that cause incapacity in nursing home residents.

more often than not, people who live in nursing homes can't move out. one of the main reasons they leave their own home is to lose their freedom. nursing homes also have a lot of people with geriatric diseases like cognitive impairment, balance problems, urinary incontinence, and disability. but it's not known what role geriatric syndromes play in adl impairment. to come up with good ways to treat geriatric syndromes, which are the main causes of adl disability in nursing home patients, we need to know more about them. so, the point of this study was to look into geriatric syndromes that are linked to disability and find out what causes disability in nursing home patients.

Eligibility criteria:
inclusion criteria: * age over 65 * staying in a nursing home for at least 12 months * consent to participate in the study were the inclusion criteria. exclusion criteria: * people who were mentally unable to answer questions, * people who were hospitalized * people who had severe hearing or vision problems that made it hard to communicate * people who took benzodiazepines or psychotropic drugs that made it hard to walk or balance * people who had fractures or endoprostheses in any part of their bodies.

Keywords: geriatric assessment activities of daily living nutritional deficiency functional dependence urinary incontinence
effects of three airway instruments on the incidence of postoperative sore throat

Conditions: Sore-throat

Summary: postoperative sore throat (post) is a common complaint after general anesthesia. post is defined by the presence of a self-reported foreign body sensation or a painful sensation in the throat after general anesthesia. this condition may affect recovery and patient satisfaction and is associated with many factors, including intubation tools. previous studies have reported conflicting results on post. this retrospective cohort study, with sample size of 10,382 patients, was conducted to confirm the hypothesis that the use of video laryngoscopy (vl) is associated with a lower incidence of post compared with direct laryngoscopy (dl).

background: postoperative sore throat (post) is a common complaint after general anesthesia. post is defined by the presence of a self-reported foreign body sensation or a painful sensation in the throat after general anesthesia. this condition may affect recovery and patient satisfaction and is associated with many factors, including intubation tools. previous studies have reported conflicting results on post. this retrospective cohort study, with sample size of 10,382 patients, was conducted to confirm the hypothesis that the use of video laryngoscopy (vl) is associated with a lower incidence of post compared with direct laryngoscopy (dl). methods: data were extracted from a prospectively maintained quality improvement database. a total of 10,382 patients were included in the study. statistical analysis was conducted for comparisons of demographic characteristics and to determine the effect of intubation tools on the incidence of post.

Eligibility criteria:
inclusion criteria: * patients receiving inpatients surgery and general anesthesia with tracheal intubation exclusion criteria: * having difficult airway, * anticipated difficult airway: 1. abnormal cervical spine movement or temporomandibular joint movement 2. airway-compromising masses such as tumors, cysts, or hematomas 3. a mallampati score greater than 3 4. a thyromental distance of less than 6 cm 5. a lesion below vocal cord 6. a previously identified difficult airway * unexpected difficult airway 1. difficult mask ventilation 2. difficult vocal cord visualization after multiple attempts of laryngoscopy * receiving laryngeal surgery, such as laryngeal biopsy, laryngeal microsurgery, laryngoplasty or vocal cord surgery, * not being extubated at the end of anesthesia, * being pregnant, * being under 20 years of age, * american society of anesthesiologists (asa) physical status class greater than 3.

Keywords: glidescope macintosh blade airway scope postoperative sore throat general anesthesia