Kornimate/medical-research-clean huggingface dataset:
trial of enteral glutamine on intestinal permeability in critically ill patients

Conditions: Critical Illness; Enteral Nutrition; Intestinal Permeability

Summary: glutamine-induced recovery in intestinal barrier function by reducing bacterial translocation was demonstrated in previous studies. in this trial, intensive care unit patients with enteral feeding will receive either enteral glutamine or maltodextrin as placebo for 10 days and the effects of the intervention on intestinal permeability will be assessed.

a randomized, double blind, controlled trial will be conducted in general intensive care unit (icu) in tehran, iran. after a full review of the inclusion and exclusion criteria and explanation of the risks and benefits of the study, written consent form will be completed. the participants are 60 eligible hospitalized patients with enteral feeding in icu, aged ≥ 18 years. intervention patients will be received 0.3 g/kg/day of glutamine along with enteral formula for 10days and control patients will be received maltodextrin along with enteral formula for 10 days. patients will be evaluated for plasma endotoxin and plasma zonulin.

Eligibility criteria:
inclusion criteria: * adult patients (\>18 years old) admitted to icu * start of study intervention within 48 hours after icu admission * expected to require enteral nutrition for at least 72 hours aiming for full enteral nutrition and receive at least 80 percent of enteral formula during the first 48 hour * written informed consent of patient or written informed consent of legal representative exclusion criteria: * enrollment in a related icu interventional study * requiring other specific enteral nutrition for medical reason * death or discharge before 5th day * having any contra-indication to receive enteral nutrition * pregnant patients or lactating with the intent to breastfeed * bmi \ 40.0 kg/m2 * have life expectancy of \<6 mo * patients who are moribond * liver cirrhosis- child's class c liver disease * have seizure disorder requiring anticonvulsant * history of allergy or intolerance to the study product components * receiving glutamine during two weeks before start study product * have other reasons

Keywords: glutamin enteral nutrition intensive care unit intestinal permeability
the effects of yoga on student mental health

Conditions: Mental Health; Public Health; Depression, Anxiety; Sleep Problem; University Students

Summary: the investigators performed a randomised controlled trial with 202 healthy university students in the oslo area, with 50:50 in a yoga intervention group and a waitlist control group. measures included symptoms of depression and anxiety, sleep problems, heart rate variability (hrv), well-being and mindfulness at week 0 (baseline), week 12 (post-intervention) and week 24 (follow-up).

universities around the world are facing an epidemic of mental health problems among their students. the problem is truly a public health issue, affecting many and with serious consequences. moreover, the global burden of disease-agenda calls for effective interventions with lasting effects that have the potential to improve the mental health of young adults. in this study the investigators aimed to determine whether yoga, a popular and widely available mind-body practice, can improve student mental health. the participants were randomly assigned to a yoga group or waitlist control group in a 1:1 ratio by a simple online randomisation program. the intervention group was offered 24 yoga sessions over 12 weeks. measurements were taken at week 0 (baseline), week 12 (post-intervention), and week 24 (follow-up). the primary outcome was psychological distress assessed by the hscl-25 questionnaire. analysis was performed based on the intention to treat-principle. the methods were laid out in a protocol, previously published on the website of the study. (available at http://yogastudy.tilda.ws/). the planned analyses were very straightforward and included a description of the study participants, and simple analyses of each of the a priori selected outcome measures. we have not included or excluded any variables post-hoc.

Eligibility criteria:
inclusion criteria: * living in the oslo area exclusion criteria: * no serious mental health diagnoses * no recent major life crisis * no systematic yoga practice during the prior six months

Keywords: mental health public health depression anxiety sleep problems insomnia yoga students
tms for anxiety and trauma-related disorders

Conditions: Anxiety Symptoms; Anxiety Disorders

Summary: the present pilot study will apply accelerated intermittent theta burst stimulation (aitbs) to a novel transcranial magnetic stimulation (tms) target for anxiety derived via causal network mapping.

anxiety-related disorders represent the most common class of mental-health disorders and are associated with high rates of non-response and relapse to current treatments. transcranial magnetic stimulation (tms) applied to the dorsolateral prefrontal cortex (dlpfc) has been shown to reduce anxiety comorbid with major depressive disorder (mdd). however, anxiety-specific targets have received insufficient attention. an anxiety specific transcranial magnetic stimulation (tms) target was recently derived via causal network mapping and was shown to reduce anxiety versus depression symptoms to a greater extent than the conventional dlpfc target in an mdd sample with comorbid anxiety. while potentially promising, this target has yet to be trialed in an anxiety-related disorder sample. the current open-label study will be the first to evaluate the preliminary effectiveness and safety of this novel right dorsomedial prefrontal cortex (dmpfc) tms target. mri-guided neuronavigation will be used to locate this target in each participant. an accelerated intermittent theta-burst (aitbs) dosing regimen will be used. based on a 90% resting motor threshold (adjusted for cortical depth), 50 sessions of itbs will be administered (1800 pulses per session, with a 50-minute inter-session interval) and delivered in a schedule of 10 sessions per day for 5 consecutive days. clinical assessments and resting-state functional mri scans will be conducted before and after aitbs. heart rate variability (hrv) and eye-movement measures will be collected before and after aitbs.

Eligibility criteria:
inclusion criteria: 1. diagnosis of generalized anxiety disorder (gad), social anxiety disorder (sad), panic disorder (pd), and/or post-traumatic stress disorder (ptsd) as defined by dsm-5 criteria. 2. male or female between 18 and 60 years old. 3. right-handed. 4. can understand and sign an informed consent document. 5. beck anxiety inventory (bai) score of 16 or higher. 6. on a stable medication/psychotherapy regimen for at least 6 weeks prior to baseline visit and throughout the duration of the study. 7. in good general health, as ascertained by medical history. 8. pharmacological treatment resistance or psychotherapeutic treatment resistance. exclusion criteria: 1. substance use disorders, eating disorders, significant suicidal ideation, mental disorder due to a medical or neurocognitive condition, lifetime psychosis, bipolar disorder, developmental disorders. 2. history of brain surgery and epilepsy. 3. presence of metallic foreign bodies, such as cardiac pacemakers and stents. 4. any medical condition or medication that increases the risk of seizures. 5. pregnancy. 6. intellectual disability. 7. current severe somatic disease, such as cancer, heart failure, pneumonia, etc. 8. severe claustrophobia that prevents the use of mri.
soy fiber improves weight loss and lipid profile

Conditions: Obesity; Overweight; Weight Loss

Summary: the aim of this study is to examine the effects of soy fiber on body weight, body composition and blood lipids in overweight and obese participants.

thirty nine overweight and obese college adults (19-39 y of age) were randomly assigned to consume control biscuits or biscuits supplemented with soy fiber for 12 wk (approximately 100g/d). information on body weight, body mass index, waist/hip circumference, blood pressure as well as measures of lipoprotein, glucose concentrations, and hba1c was obtained at baseline, 8 and 12 wk after intervention. body composition was also assessed at baseline and wk 12, respectively.

Eligibility criteria:
inclusion criteria: * bmi of 23-35 kg/m2 exclusion criteria: * subjects taking any drugs, botanicals or nutraceutical known to influence body weight or blood pressure * significant history of eating disorders * strenuous exercise to lose weight * lipid-lowering medication * use of steroids and other agents that may influence lipid metabolism * hyperlipidemia * hyperglycemia * diabetes mellitus * cardiovascular disease * major systemic diseases * gastrointestinal problems * liver and renal failure
comparison of candida eradication and serum cidal activity of echinocandins

Conditions: Candidemia

Summary: the purpose of this pharmacokinetic (pk) and pharmacodynamic (pd) study is: to study the rate and duration of serum cidal activity of caspofungin (cfg) and micafungin (mfg) against candida isolates from the subject and against candida glabrata with varying degrees of caspofungin susceptibilities. this investigation will provide clinicians information supporting the use of caspofungin and micafungin in situations where candida strains may be a cause of infection.

methods: patients - adult patients with presumptive candidemia. patients with severe neutropenia (\ 20, or significant liver disease will be excluded. all will give written informed consent (pappas et al. cid. oct 1, 2007). drugs - patients will receive either cfg: 70 mg loading dose (ld) followed by 50 mg once daily (qd) (8 patients), mfg: 100 mg qd (8 patients) or mfg: 200 mg qd (8 patients). all agents will be given by slow iv infusion (mfg will be supplied by astellas). sera - blood samples will be collected at the end of the infusion (peak) and at 12 h and 24 h (trough) after the beginning of an infusion (day 3-4). each patients sera will be tested (mic and cidal activity) against their own candida isolate (if isolated). in addition, recent clinical isolates of c. glabrata will also be tested against patient sera (time-kill) to verify previous in vitro and animal pd studies (cota. aac. nov. 2006; wiederhold. aac. may 2007). results: * patient outcome, including candida eradication, will be documented for each patient by repeat culture. * serum concentrations (lab to be determined) and pk analysis of each echinocandin will be determined for each patient. * serum cidal titers will be measured against each of the candida isolates for each agent at each time period. median and geometric mean peak and duration of cidal activity will then be determined and compared.

Eligibility criteria:
inclusion criteria: * adult patients with presumptive candidemia exclusion criteria: * patients with severe neutropenia (\<500) * patients with apache ii scores \> 20 * patients with severe liver disease

Keywords: candidemia echinocandin micafungin caspofungin
safety and efficacy of umbilical cord mesenchymal stem cell therapy for patients with duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy

Summary: duchenne muscular dystrophy (dmd), an x-linked recessive genetic disease always progressed slowly，tends to leading proximal skeletal muscle atrophy and weakness of limbs, as well as impaired respiratory muscle and cardiac muscle. to a large extent, patients always lose motor function gradually and die for heart failure or severe infection at the end stage of dmd. at present, the treatment strategy relies on heteropathy accompanied with rehabilitation training. however, the therapeutic effect remains extremely limited. human umbilical cord mesenchymal stem cells (huc-mscs) have been evidenced to improve motor function, increase muscle strength and reduce abnormal levels of related enzymes, such as creatine kinase (ck), lactate dehydrogenase (ldh), alanine aminotransferase (alt) and aspartate aminotransferase (ast). this study is aimed to explore the safety and efficacy of huc-mscs transplantation for dmd.

this study is designed to investigate the safety and efficacy of human umbilical cord mesenchymal stem cells transplantation in patients with progressive muscular dystrophy.

Eligibility criteria:
inclusion criteria: * aged 5-12 years * clinical manifestation, enzymology, electromyogram, gene type confirmed the diagnose of duchenne muscular dystrophy * sign the consent form and follow the clinic trail procedure exclusion criteria: * not duchenne muscular dystrophy * any history of hypersensitivity to serum products,or other know drug and food allergy * combined pneumonia or other severe systemic bacteria infection * hiv+, tppa +， patients diagnosed as hbv or hcv * tumor markers + * severe psychotic patients, cognitive dysfunction * coagulation disorders * uncontrolled hypertension after treatment，blood pressure≥180mmhg/110 mmhg * other severe systemic or organic disease * enrollment in other trials in the last 3 months * received any stem cell therapy in past 6 months * other criteria that investigator consider improper for inclusion

Keywords: duchenne muscular dystrophy human umbilical cord mesenchymal stem cells
the impact of glycemic index education on lowering dietary gi in gestational diabetes mellitus

Conditions: Gestational Diabetes Mellitus

Summary: gestational diabetes mellitus (gdm) incidence is increasing worldwide, and within canada, the atlantic provinces statistically have been found to have highest prevalence of diabetes. increasing evidence supports the benefit of following a low glycaemic index (gi) diet in gdm and the canadian diabetes guidelines recommends replacing high gi foods for low gi foods. despite recommendation to adapt a low gi diet in gdm, there are limitations and barriers recognized to gi utility largely focused on knowledge translation. there is sufficient research to support a low gi diet in benefiting outcomes of gdm, therefore the gi in gdm online trial will investigate the feasibility and effectiveness of a distance low gi education intervention, adapted from diabetes canada's gi materials, on producing a difference in average dietary gi between a group with the intervention and standard care.

the incidence of gestational diabetes mellitus (gdm) has been progressively increasing worldwide, with a global prevalence of gestational hyperglycaemia estimated at 16.9%. in canada, atlantic provinces have been recorded with the highest prevalence of diabetes at 6%. the diabetes canada practice guidelines recommends the low glycemic index (gi) diet to type 1 and 2 diabetes mellitus and has recently updated its guidelines to include a recommendation for gdm. this said, barriers to gi knowledge translation have been identified. this study uses a prospective parallel randomized control trial design. procedures and materials have been adapted from nct01589757. the kirkpatrick model (reaction, learning, behaviour, and results) informed intervention development and evaluation strategies. the purpose of this study is to evaluate whether a distance low gi education intervention, adapted from diabetes canada's gi education materials, will significantly yield a lower average gi (primary outcome) in participants than traditional standard care medical nutrition therapy for gestational diabetes mellitus. we hypothesize that participants who receive the low gi intervention will have a lower dietary gi than those who received usual iwk standard care for gdm.

Eligibility criteria:
inclusion criteria: * of or over 18 years of age * diagnosed with gdm according to diabetes canada * at or over than 20 weeks gestation * at or less than 32 weeks gestation * being followed at iwk health centre * willing and able to give informed consent * willing and able to complete study protocol * currently living in nova scotia exclusion criteria; women who: * have been diagnosed with acute or chronic illness, other than gdm and pcos, that may impact carbohydrate digestion metabolism. * are currently taking a medication (other than insulin) that may affect carbohydrate metabolism. * have multi-fetal pregnancy in current pregnancy. * have insurmountable language barriers.

Keywords: gestational diabetes glycaemic or glycemic index nutrition education behaviour
comparative analysis of ds and nmt on pelvic inclination in early middle-aged patients with radicular low back pain

Conditions: Low Back Pain

Summary: radicular low back pain (rlbp) is a common and debilitating condition characterized by nerve root irritation or compression, often resulting in altered biomechanics, muscular imbalances, and postural deviations such as anterior pelvic tilt.

rehabilitation strategies commonly focus on improving flexibility, neuromuscular control, and nerve mobility. among these, dynamic stretching and neural mobilization techniques have shown individual effectiveness, but limited evidence exists on their comparative or combined effects on pelvic alignment and functional outcomes, particularly in early middle-aged adults. addressing this gap could support the development of more targeted, evidence-based rehabilitation protocols.

Eligibility criteria:
inclusion criteria: * both male and female * early middle-aged adults (aged 35-55 years) * diagnosed with radicular low back pain (rlbp) lasting more than 4 weeks * positive straight leg raise (slr) or slump test * able to participate in physical therapy sessions 3 times/week(26) exclusion criteria: * history of spinal surgery or fractures * severe neurological deficits (e.g., foot drop, bladder/bowel dysfunction) * diagnosed with inflammatory or systemic conditions (e.g., ankylosing spondylitis, rheumatoid arthritis) * concurrent participation in other physical therapy programs * pregnant women or individuals with severe cardiovascular conditions
predictors of the ability to protect the airway in long-term ventilated patients

Conditions: Swallowing Disorder; Aspiration; Long Term Ventilation

Summary: first part of a 2 part study with the same irb protocol #, and labeled 'a'. investigators hypothesized that clinical muscle strength assessment (manual muscle testing) predicts the ability to protect the airway during swallowing in long-term ventilated subjects. more specifically, the investigators hypothesized that low muscle strength is associated with the inability to clear secretions from the peri-laryngeal area (valleculae and pyriform sinus residue scale (vpsr scale \[nrs: 0-4\] of \> 1) and entering the materials into airway (pas scale \[1-8\]\> 1), which should predispose to endotracheal aspiration.


Eligibility criteria:
inclusion criteria: 1. patients admitted to the respiratory acute care unit and surgical intensive care unit, units with a mixed collection of long term ventilated patients in a major academic teaching hospital. 2. age over 18 years. 3. long-term ventilated patients (\>10 days) with tracheotomies exclusion criteria: 1. decreased level of consciousness as defined by a richmond agitation sedation scale (rass) of 0. 2. non-cooperative patient, cam score positive for delirium. 3. for women: pregnancy.

Keywords: fees pas vpsr mrc
eeg and nirs in preterm infants

Conditions: Premature Birth

Summary: experimental cross-sectional study of a single application (vojta therapy or massage) in preterm and non-preterm infants to test whether there are differences in brain activation and oxygenation that occur with both techniques between term and preterm infants. secondly, the brain activation and oxygenation produced by both physiotherapy techniques will be tested separately to establish comparisons between the two groups. finally, between 3 - 6 months, we will analyse whether there are changes in gaze fixation (eye tracker) in the 4 study arms to see if there are differences between term and preterm infants but also the differences between the immediate effectiveness of both techniques.


Eligibility criteria:
inclusion criteria: * term and preterm babys * first month after birth exclusion criteria: * intrumental delivery * pathology associated

Keywords: preterm premature infant baby child
individualized diet improvement program for weight loss and maintenance, cohort 2

Conditions: Obesity; Overweight; Weight Loss; Diet Habit

Summary: this research is to develop a weight loss and weight maintenance program through dietary modifications for adults with obesity. although scientific studies have shown the feasibility of rapid and safe dietary weight loss and subsequent weight maintenance, no efficacious dietary weight management program is widely available, and thus bariatric surgery remains the most reliable approach for weight loss/management. safe and effective dietary weight loss and subsequent weight maintenance require flexible, individualized advice by an experienced dietitian/nutritionist.


Eligibility criteria:
inclusion criteria: body mass index in the overweight or obese range (bmi) \>28 kg/m2 (if asian, bmi \>25kg/m2); not currently pregnant or lactating; have wi-fi at home, a working email, and an iphone or android smartphone; no self-reported severe metabolic, cardiovascular or musculoskeletal disease; not using insulin injection; able to attend the 22 (1 hour) diet improvement sessions; willing to lose 20 lb. or more for 6 months and maintain a healthy weight for one year; keep weighing their weight for two years; fluent in reading and writing english. exclusion criteria: age \ 70 years; body mass index of \<28 kg/m2 (if asian, bmi \<25kg/m2); currently pregnant; currently lactating; self-reported with severe metabolic, cardiovascular, or musculoskeletal disease; use insulin injection; not able to attend the 22 (1 hour) diet improvement sessions for 1 year; failed to set up a wi-fi scale; failed to submit a ffq.
the mechanism of modified utral-long protocol in improving endometrial receptivity in patients with pcos and ir

Conditions: PCOS

Summary: nf-κb pathway activation-induced endometrial insulin resistance was one of the causes of infertility patients with pcos and insulin resistance whose endometrial receptivity is declined .the investigators' previous findings indicated that the use of modified utral-long protocols ( gnrh-a was used twice in mid-luteal phaes) can improve clinical outcomes by improving endometrial receptivity in patients with pcos , but the mechanism was not clear. previous research also found that gnrh-a reduced the activity of nf-κb pathway in endometrial stromal cells and depended the dose and time.thus, the investigators' subject will try to applicate gnrh-a to explore the influence of nf-κb pathway activity 、the state of insulin resistance and embryo implantation rate ;then we will investgate gnrh-a whether reduce nf-κb pathway activity-induced insulin resistance and ultimately improve endometrial receptivity by using gnrh-a in infertility patients with pcos and insulin resistance.the investigators' research attempt to provide ideas for seeking inflammatory medication target in assisted reproductive technology in patients with pcos by exploring the immune mechanism of gnrha on improving the endometrial receptivity .

the endometrial biopsy was performed in the previous cycle of the protocol. according to the expression of nf-κb in the endometrium random group. the difference of nf - κb expression in patients with different protocol were compared.

Eligibility criteria:
inclusion criteria: * age\<36years, * pcos, * insulin resistance (homa-ir = fasting insulin (fins) × fasting blood glucose (fpg) / 22.5, homa-ir ≥ 2.69 ）; exclusion criteria: * uterine abnormalities (double uterus, bicornuate uterus, unicornuate uterus and uterine mediastinum), * intrauterine adhesions, * endometriosis, adenomyosis, * hydrosalpinx, * uterine fibroids (submucosal fibroids, non-mucosal fibroids \> 4 cm and / or endometrial pressure), * hyroid dysfunction and hyperprolactinemia.