Kornimate/medical-research-clean huggingface dataset:
influence and mechanism of dyadic coping on parenting stress and parenting self-efficacy in parents of preterm infant

Conditions: Premature Infant Disease

Summary: the goal of this observational study is to investigate the parenting stress, parenting self-efficacy and dyadic coping of preterm parents and explore the influence and pathway analysis of dyadic coping between parenting stress and parenting self-efficacy.

for now, there is a lack of investigation and research on parenting stress, parenting self-efficacy and dyadic coping of co-parenting for discharged premature infants in the literature, and the mediating effect of dyadic coping between parenting stress and parenting self-efficacy of preterm parents has not been verified yet. this study aims to provide a theoretical basis for effective intervention for preterm parents with high parenting pressure and insufficient parenting self-efficacy in clinical work.

Eligibility criteria:
inclusion criteria for parents * parents of hospitalized preterm infants with a gestational age of less than 37 weeks; * both parents are at least 18 years old; * able to read and communicate in chinese, able to complete the questionnaire independently or with the help of the investigator; inclusion criteria for infants * gestational age less than 37 weeks; * admitted to the nu or nicu and discharged after treatment exclusion criteria for parents * single-parent family; * parents diagnosed with severe anxiety and depression; exclusion criteria for infants * for birth defects cannot be cured and affect the quality of life; * infants who were given up treatment due to illness or family reasons; * transferred or death;

Keywords: premature infant parental self-efficacy parenting stress dyadic coping
maternal epidural steroids and hyperthemia

Conditions: Fever; Labor Pain; Complication of Anesthesia During Pregnancy, Unspecified

Summary: the purpose of this study is to look to see if adding steroids to an epidural reduces the chances of having a fever in labor, and protects the baby from exposure to inflammation.

the association between epidural analgesia and increased maternal intrapartum temperature has been well documented in multiple randomized controlled trials. the exact mechanism for this elevation in temperature is unknown; however the most likely cause appears to be non-infectious inflammatory stimulation. fetal exposure to maternal fever in utero has been linked with increased antibiotic treatment, increased neonatal sepsis evaluation, and longer length of stay for neonates. in addition there is evidence to suggest intrapartum fevers may lower the threshold for fetal hypoxic brain injury and increase the risk of cerebral palsy. the risk of neonatal encephalopathy in infants born to febrile mothers is 1% compared to 0.1% to afebrile mothers. safe interventions are needed to prevent adverse fetal outcomes.

Eligibility criteria:
inclusion criteria: * nulliparity * age\>=18 * patient requests epidural analgesia * ga \>= 37 weeks exclusion criteria: * no prenatal care * temperature \>99.4 at decision for epidural placement * cervical dilation \>4cm * diabetes (pre-gestational or gestational) * autoimmune condition * pre-eclampsia * maternal heart disease * current steroid use * active infection (bacterial or viral) * wet tap (csf on placement of epidural) * pre-gestational diabetes * known systemic infection (bacterial, viral, fungal or tubercular) * known allergy to steroids * heart failure * hypertensive crisis * history of active epilepsy
retrospective experience assessing the real-world utilization and effectiveness of sevenfact®

Conditions: Hemophilia

Summary: retrospective experience assessing the real-world utilization and effectiveness of sevenfact® \[coagulation factor viia (recombinant)-jncw\] in the usa. the current study will provide a unique opportunity to describe the profile of the early patients selected for treatment with sevenfact® and to assess the real-world utilization (effectiveness, safety, tolerability, and modalities of treatment) of sevenfact®.

parameters collected will include patient socio-demographics, medical history / comorbidities, bleeding disorder history, physical examination, vital signs, prior and concomitant bleeding disorder treatments, bleeding episode / surgery or invasive procedure / prophylaxis details, information on sevenfactâ treatment modalities, retrospective investigator rating of sevenfactâ effectiveness using the clinical global impression efficacy index (cgi-e) and time for bleed control, adverse drug experiences (ades) temporally associated with sevenfactâ administration, special situations that occurred during sevenfactâ administration, whether or not associated with ade, laboratory testing for activation of the coagulation system or thrombosis, physical examination, and vital signs.

Eligibility criteria:
inclusion criteria: 1. patient received sevenfact® before study initiation. 2. if collection of a written informed consent is required for an investigational site (see section 5.1 general informed consent), patient has read, understood, and documented written informed consent/assent. exclusion criteria: not applicable

Keywords: inhibitors eptacog beta recombinant factor 7 real-world evidence
eccentric training and cryotherapy vs eccentric training and whole body vibration in achilles tendinopathy

Conditions: Achilles Tendon; Tendinopathy

Summary: the purpose of this study is to determine the effectiveness of eccentric exercise combined with vibration or cryotherapy in achilles tendon pathology. the investigators hypothesis is that the combined eccentric exercise is better than the results presented by the exclusive eccentric exercise. this intervention differs from the classic studies in that we maintain the intensity throughout the treatment.


Eligibility criteria:
inclusion criteria: * sports people * positive initial ultrasound diagnosis * presence of degenerative changes at achilles mid portion * chronic achilles tendon pain, (3/10 vas) * pain when walking or running of achilles tendon, (3/10 vas) * pain in load in plantar flexion of achilles tendon, 3/10 vas) * pain in palpation of achilles, (3/10 vas) * morning stiffness inclusion criteria healthy pople: * sports people * negative initial ultrasound diagnosis * no syntomp of achilles tendinophaty exclusion criteria: * receive physical, orthotic or physiotherapeutic treatment * asociated low back pain, ankle/knee/hip injury that may affect the study * previous injury or surgery of achilles tendon. * pathologies that may limit the joint of ankle * pregnancy * obesity * patients with diabetes and/or other endocrine or metabolic pathologies or neurologic pathologies * patients diagnosed with cardiovascular disease * subjets diagnosed with familiar hypercholesterolemia and/or presence of xanthomas or with hyperuricemia * patients who have received renal transplantation * subjects who have suffered retinal detachment * subjects who have received oral contraceptives, statins, corticoids or hormone replacement therapy in the last six months * subjects who have received treatment wiht fluoroquinolones in the last two years * subjects who have received treatment with aine's in the last four weeks

Keywords: eccentric exercise whole body vibration cryotherapy
burnout among caregivers facing covid-19 health crisis at a non-conventional intensive care unit compared to a conventional intensive care unit

Conditions: COVID-19; Burnout, Caregiver; Intensive Care Unit; Stress, Psychological

Summary: the intense health crisis due to covid-19 led to a profound reorganization of the activities at theatres, recovery rooms and the intensive care units. the caregivers are facing several issues and are daily exposed to an intensification of the work. assessing the stress and the well-being of the caregivers is very important in this context.

the current period of intense and prolonged health crisis has necessitated a profound reorganization of the activities and organizations of the intensive care hospital services in order to be able to cope with it. caregivers are at the heart of the management of this crisis and are exposed daily to these situations of repeated emergencies, an intensification of the pace of work and difficulties in care. in this context, it seemed important to us to try to quantify this pressure of care, in order to be able to offer in second care adapted to caregivers who would like it. the assessment of the mental state of the caregivers as well as the collection of the feelings and perceptions on the current crisis and its management will be carried out by anonymous and voluntary self-questionnaire in collaboration with the service of professional pathologies and occupational medicine of the hospital structure

Eligibility criteria:
inclusion criteria: * consent to participation; caregivers working at recovery room; caregiver working at intensive care unit exclusion criteria: * refusal of participation
perioperative chemotherapy with bevacizumab for colorectal carcinomatosis

Conditions: Colorectal Neoplasms

Summary: the bev-ip trial is designed to assess the feasibility and efficacy of a combined treatment consisting of perioperative combination chemotherapy with the vascular endothelial growth factor a inhibitor bevacizumab and cytoreductive surgery with intraperitoneal oxaliplatin.


Eligibility criteria:
inclusion criteria: * biopsy proven adenocarcinoma of the colon or rectum and synchronous or metachronous peritoneal carcinomatosis. * absence of systemic disease, with the exception of small, superficial liver metastases, requiring only minor surgery. * resectable disease at staging, during laparoscopic evaluation and during exploration for cytoreductive surgery and intraperitoneal chemotherapy. * complete macroscopic cytoreduction at the time of surgery (cc-0/1) * good general health status (karnofsky index \> 70%) * expected life expectancy more than 6 months * no other malignancy than disease under study * serum creatinine \< 1.5 mg/dl or a calculated gfr ≥ 60 ml/min/1.73 m * serum total bilirubin \< 1.5 mg/dl * platelet count \> 100,000/ml * hemoglobin \> 9g/dl * neutrophil granulocytes \> 1,500/ml * international normalized ration (inr) 2 or \< 2 * absence of alcohol and/or drug abuse * no inclusion in other clinical trials interfering with the study protocol * no concurrent chronic systemic immune therapy, chemotherapy, or hormone therapy not indicated in the study protocol * absence of heart failure (nyha 2 or \> 2) or significant coronary artery disease * no pregnancy or breast feeding * adequate contraception in fertile patients exclusion criteria: * no written informed consent * tumour in the presence of obstruction * evidence of extra-abdominal disease or extensive liver metastasis * peritoneal cancer index \> 25 * active bacterial, viral or fungal infection * active gastro-duodenal ulcer * parenchymal liver disease (any stage cirrhosis) * uncontrolled diabetes mellitus * severe obstructive or restrictive respiratory insufficiency * psychiatric pathology capable of affecting comprehension and judgment faculty * known allergy to oxaliplatin

Keywords: cytoreductive surgery hipec perioperative chemotherapy peritoneal carcinomatosis bevacizumab colorectal surgery
text reminders to immunize in a managed care organization

Conditions: Human Papilloma Virus

Summary: the purpose of the study is to evaluate the effectiveness of a managed care-based hpv vaccination reminder/recall system using a randomized controlled trial (rct) across diverse practices and patient populations. the trial will measure the effectiveness of text messaging reminder/recall on (a) improving initiation and (b) completion rate of the hpv vaccine series; (c) decreasing the time between vaccine doses; and (d) improving rates of preventive visits for adolescents the hypotheses are that text-messaged reminders to parents of adolescents will result in improved rates of hpv vaccine series initiation, hpv vaccine series completion, will decrease the intervals between vaccine doses and will improve rates of preventive care among adolescents. parents receiving specific text-messaged reminders about services (i.e. hpv vaccination, well child care visits) for which their adolescent is due will be compared to a control group of parents receiving general health tips through text messages.

the study setting is western new york state and the southern tier of new york state (15 counties total). investigators will work with the monroe plan for medical care, an ipa-model managed care organization (mco) that serves medicaid managed care and schip enrollees. the mco will conduct regular reviews of insurance claims data and the new york state immunization information system of adolescents ages 11-\<16 years. parents (all over 18 years of age) of adolescents will receive the texted messages on their phones. there are no enrollment restrictions based upon race or ethnic origin. the inclusion criteria are that the adolescents are a) enrolled in medicaid or schip through the monroe plan, b) have been enrolled greater than 6 months with the monroe plan (in order to have sufficient claims data to determine whether they are due for a well child care visit or recommended immunizations), c) the monroe plan has received their consent to send preventive care text messages, d) their child attend a primary care practice that has agreed to participate and d) they are between the ages of 11-\<16 years at the start of the study. the key independent measure is group allocation (intervention vs. control); an intention-to-treat strategy will be used to assess the effectiveness of text messaging reminders. key outcome measures will be: 1) receipt of 0, 1, 2 or 3 doses of hpv vaccine 2) interval (in days) between doses and 3) having a preventive visit in the 6 month period.

Eligibility criteria:
inclusion criteria: * 11-\<18 years * member of mco for \>6 months * opted in to receive texted reminders from mco exclusion criteria:

Keywords: hpv vaccination adolescent well care adolescent hpv immunization hpv
intravenous lidocaine infusion in the management of post-operative pain in colorectal patients

Conditions: Colorectal Disorders

Summary: the purpose of this study is to determine if an intravenous lidocaine infusion (compared to placebo) intraoperatively will decrease time to return of bowel function postoperatively, decrease postoperative pain, diminish postoperative opioid requirement, minimize inflammatory markers and shorten time to discharge after colorectal surgery.

lidocaine is an amide local anesthetic that has analgesic and anti-inflammatory properties. lidocaine infusion is a very useful pain medication that is underutilized to treat surgical, chronic, and cancer pain in children. the investigators propose to examine the perioperative use of lidocaine infusion in children undergoing colorectal surgery that involves an abdominal incision. the investigators plan to measure the following outcomes: length of stay in hospital following abdominal surgery, postoperative pain scores, cumulative morphine consumption, incidences of opioid adverse-effects: respiratory depression, sedation, nausea, vomiting, time to passage of flatus, time to first bowel movement and end-tidal sevoflurane in operating room throughout surgery. the following laboratory values will be measured: serial lidocaine levels of pharmacokinetics and safety levels, pro- and anti-inflammatory cytokine measurements: il-6, il-8, il-10, il-1ra and genetic variants.

Eligibility criteria:
inclusion criteria: * male or female children 1-15 years of age * asa physical status 1-3 * scheduled for colorectal surgery with abdominal incision * scheduled for complex urology surgical case exclusion criteria: * asa physical status \> 3 * postoperative intubation planned ahead of surgery * history of chronic use of opioid * history of hepatic,renal, or cardiac failure * history of organ transplant * bmi \> 30 * history of cardiac arrhythmia * history of long qt syndrome * history of allergic reaction to lidocaine or similar agents * history of seizure disorder * patient without peripherally inserted central catheter or other central access with contraindication to inhalation induction * family history or know patient susceptibility to malignant hyperthermia
attenuation of pain in men and women

Conditions: Pain

Summary: the purpose of this study is to examine opioid and endocannabinoid mechanisms of exercise-induced analgesia in men and women.


Eligibility criteria:
inclusion criteria: healthy men and women - exclusion criteria: * current cardiac or other chronic diseases (e.g., cancer, diabetes, hypertension, kidney disease); routine use of prescriptive medications; history of vasovagal response to phlebotomy; an allergy to naltrexone; pregnancy; current smokers; current use of recreational drugs; history of substance abuse
effect of adding dexmedetomidine as adjuvant to bupivacaine in us guided espb for post mrm pain management

Conditions: Erector Spinae Plane Block

Summary: the aim of the study is to assess the effect of adding dexmedetomidine to bupivacaine in us guided erector spinae plane block in modified radical mastectomy surgeries , using visual analogue score and post-operative narcotics consumption. peripheral nerve blocks are effective adjuvant options for pain management in breast surgeries. the use of erector spinae plane block (espb) has been proven to be very effective in controlling pain and minimizing narcotic consumption after modified radical mastectomy surgeries. many adjuvants to local anaesthetics were used to improve the duration and intensity of the peripheral nerve block.

breast cancer is one of the most important medical problems in the female gender, since among every eight women, one will suffer from breast cancer during her lifetime. acute post-operative pain is very common after breast surgeries which requires adequate pain management. different peripheral nerve blocks such as paravertebral block had been used as an analgesic option for breast surgeries. erector spinae plane block is a newer interfascial plane block first described in 2016 who used it for treating thoracic neuropathic pain by injecting a local anesthetic deep into the erector spinae muscle at the level of t5. moreover, espb is a reasonable option, with clearly identifiable sonographic landmarks and la needle insertion and injection locations. later studies have shown that espb can provide effective analgesia in breast surgeries. espb is achieved by injecting the local anesthetics locally deep to erector spinae muscle surface, as a part of multimodal analgesia. given that erector spinae muscles anatomically situate along the thoracolumbar spine, espb promotes an extensive craniocaudal spread. ultrasound is a non-invasive visualization technology that helps in capturing the anatomical structure of target tissues, it can help to guide the direction and depth of anesthesia puncture needles, thus reducing the risk of complications . adjuvants to local anesthetics, such as opioids, alpha 2 agonists, magnesium and dexamethasone may improve the duration and intensity of peripheral nerve blocks effect.

Eligibility criteria:
inclusion criteria: * age:30-65years. * physical status: asa i,ii. * bmi\<35. * localized breast cancer exclusion criteria: * age:\ 65 years. * refusal of procedure or participation in the study by the patient. * physical status: asa iii or above. * history of allergy to the study drug. * bmi\>35. * bleeding disorders and coagulopathy. * psychiatric illness that may interfere with the study. * metastatic breast cancer.
the reliability and validity of the l-test in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: walking safely inside or outside is an important function in patients with multiple sclerosis (pwms) that affects their daily life activity and participation. loss of functional mobility is the major component of walking disorders in pwms. therefore, it is important to evaluate functional mobility. many functional mobility tests have been used for pwms; however, these tests generally focus on walking speed and endurance. on the other hand, the l test, a variation of the timed up and go test (tug), is a functional mobility measurement tool that extends the total walking distance to 20 meters and also requires the patients to turn both clockwise and counterclockwise. although l the test is an easy-to-use, short-term test method that evaluates higher-level components of functional mobility such as turns and transfers, to our knowledge, no study has systematically examined the reliability and validity of the l test in pwms yet. in addition, the cut-off times that best discriminate pwms from healthy people and fallers with non-fallers with multiple sclerosis (ms) have not been reported. therefore, this study planned to investigate the reliability, validity, and discrimination of the l test in pwms.

at baseline, the l test, timed up and go test, 10 meter walk test, six minute walk test, and the timed 360 turn test will be applied to the multiple sclerosis group. the l test will be repeated after seven days after the first application in pwms. healthy controls are going to perform only the l test.

Eligibility criteria:
inclusion criteria: * age at least 18 years, * neurologist-diagnosed multiple sclerosis, * expanded disability status scale (edss) score between 0-5, * no ms exacerbation within the last 3 months, * use of stable medication in the last 3 months. exclusion criteria: * having any vision, hearing, or perception problems that may affect the research results, * having an orthopedic problem that will prevent walking and standing * having a cardiovascular, pulmonary, or hormonal disorder

Keywords: l test multiple sclerosis functional mobility reliability validity