Kornimate/medical-research-clean huggingface dataset:
effect of vitalstim in patients with chronic post-stroke oropharyngeal dysphagia

Conditions: Deglutition Disorders; Stroke

Summary: prospective, randomized, controlled, three-arm, open-label, blinded analysis. patients admitted with stroke diagnosis and with suspected dysphagia that meet the initial inclusion and exclusion criteria will be consented into the clinical investigation. patients who meet the second set of inclusion criteria (dysphagia confirmed by vfs) will be randomized to either active (motor or sensory) or standard treatment (control group) arms. subjects included in this clinical investigation will be evaluated at screening, 1-week, 3-months and at 12-months post treatment. the main aim of the study will be to assess the effect of vitalstim therapy on improving the safety of swallow according to the vfs, after the treatment and at 1-year follow up, on patients with chronic post-stroke od.


Eligibility criteria:
inclusion criteria: * subject is over 18 years of age. * subject is suspected of having oropharyngeal dysphagia. * subject is able to comply with videofluoroscopy protocol. * subject diagnosed with stroke. * subject has no previous history of dysphagia. * subjects who are able to give voluntary, written informed consent to participate in the clinical investigation and from whom consent has been obtained/ or a consultee has consented on the subjects behalf in line with nationally agreed guidelines concerning adults unable to consent for themselves. * subject is not currently participating in any other interventional clinical study. * subject is able to comply with the protocol requirements * subject scores 0 or 1 on question 1a of nihss randomization inclusion criteria: • subject has confirmed dysphagia (pas of 2 or more on vfs screening or pharyngeal residue). exclusion criteria: * subject stroke event occurred less than 3 months ago. * subject is pregnant or a nursing mother. * subject, in the opinion of the investigator, has advanced dementia * subject fitted with a pacemaker or implantable cardiac defibrillator * subject is dysphagic from conditions other than stroke * subject has been diagnosed with a progressive neurological disorder, such as parkinson's disease or multiple sclerosis. * subject with active neoplasm or infection process.

Keywords: dysphagia vitalstim electrical stimulation
snap: switching nucleoside analogues protocol - lipoatrophy and mitochondrial function

Conditions: HIV Infection

Summary: hiv infected subjects receiving antiretroviral treatment for greater than 6 years with be evaluated for clinical lipoatrophy and mitochondrial function after switching nucleoside analogues from stavudine (d4t) to tenofovir treatment and after 4. hypothesis: tenofovir therapy will increase peripheral fat content as assessed by dexa and mitochondrial function at 48 weeks.

hiv infected subjects receiving antiretroviral treatment (lopinavir/ritonavir, stavudine, and lamivudine) for greater than 6 years through the abbott m97-720 protocol with be evaluated for clinical lipoatrophy and mitochondrial function prior to switching nucleoside analogues from stavudine (d4t) to tenofovir and after 48 weeks or tenofovir treatment. subjects with or without lipoatrophy are eligible for the study. adipose tissue biopsies to measure mitochondrial function, metabolic laboratory tests, and daxa scans and clinical evaluations of lipodystrophy will be performed at entry and after 48 weeks of tenofovir treatment.

Eligibility criteria:
inclusion criteria: * hiv infection * receiving kaletra, stavudine, and lamivudine for greater than 6 years (through abbott m97-720 study) * planning to switch from stavudine to tenofovir exclusion criteria: * will continue to receive stavudine

Keywords: lipoatrophy mitochondrial function nucleoside analogue switch treatment experienced
effects of the insole on balance capacity in chronic stroke

Conditions: Stroke, Cardiovascular

Summary: poor balance capacity is one of clinical symptoms of stroke patient. the reason of loss balance capacity is motor impairment, as well as a diminished capacity to voluntarily shift body weight or to with stand external pertubations. postural movement patterns include three discrete control strategies: hip, knee, and ankle strategy. the ankle rocker is an important factor to maintain balance during standing and the ankle strategy restores the center of mass (com) to a position of stability through body movement. as a result, effective control of foot motion and ankle stability may decrease postural sway and the risk of fall in chronic stroke.the purpose of this study is to investigate the effects of the insole on balance capacity in chronic stroke.

an important determinant of activities of daily living performance is standing balance. therefore, poor balance, or postural stability, is significant predictors the risk of fall. after a fall, the patient can experience psychological, physical, social, economic, and sometimes fatal effects. the injuries can reduce the patient's mobility as well as independence and influence quality of life.patients with chronic stroke wearing functional insoles and sham insoles to challenge balance tests.

Eligibility criteria:
inclusion criteria: * a history of unilateral chronic stroke occurrence over 6 months prior to the study * ability to understand verbal instructions. * ability to walk 5 meters independently without the need of ankle-foot orthosis. exclusion criteria: - a diagnosis of other neurological or musculoskeletal disorders that could affect postural balance.

Keywords: stroke balance insole
neural circuits for action perception

Conditions: Epilepsy

Summary: study the mechanisms underlying action recognition and execution

subjects will participate in a task where they have to either 1. perform a movement 2. observe an actor performing a movement there are three types of actions including different kinematics and grip types the goal is to compare the neural circuits activated by action execution versus action observation.

Eligibility criteria:
inclusion criteria: * patients with pharmacologically intractable epilepsy exclusion criteria: * any situation that may put the patient at risk
establish diagnostic models based on portal venous blood for pancreatic cancer

Conditions: Diagnoses Disease

Summary: explore new markers based on portal venous blood sampling to establish novel diagnostic models for identification of malignant pancreatic mass.

eus-fna combined cytology detection is an important method for clinical diagnosis of squamous cell carcinoma. however, due to factors such as sampling method, smear making, staining technique, lower levels of the pathologists and other factors, its diagnostic sensitivity is still not very satisfactory. poor diagnostic efficacy usually means another puncture, longer hospital stay, more medications and a higher incidence of adverse events. missed diagnosis continuously directly delays the treatment time of the disease and seriously affects the patient's prognosis. therefore, how to use new technologies to improve the differential diagnosis efficiency of benign and malignant pancreatic occupants is the key to improving the prognosis of diabetic cancer patients. the portal vein blood comes from the venous tract, including the blood flowing from the plasma to the liver. by collecting blood samples from the patient's portal vein, clinicians can separate more information from the patient. studies have shown that the portal vein blood can be collected by ultrasound endoscopic puncture. this method is less traumatic, convenient and safe, and more information about the retinal tissue can be obtained. it is an important way to improve the efficiency of patient diagnosis. this study intends to use ultrasound endoscopic puncture technology to obtain portal vein blood, and use big data and ctdna, metabolomics, exosomes and other different omics methods to screen the potential value of volume-occupying benign and malignant differential diagnosis markers in portal vein blood. peripheral blood will simultaneously be collected to evaluate the efficacy of these newly developed markers.

Eligibility criteria:
inclusion criteria: 1. age 18-75 years,male or female 2. diagnosis or suspection of solid pancreatic mass based on previous imaging examination (ultrasonography, ct or mri) 3. lesion diameter larger than 1 cm 4. signed informed consent letter exclusion criteria: 1. pregnant female 2. pancreatic cystic lesions 3. anticoagulant/antiplatelet therapy cannot be suspended 4. unable or refuse to provide informed consent 5. coagulopathy (platelet count \ 1.5) 6. severe cardiopulmonary dysfunction that cannot tolerate intravenous anesthesia 7. with history of mental disease 8. other medical conditions that are not suitable for eus-fna

Keywords: diagnosis and pancreatic cancer
modifying working memory with brain stimulation

Conditions: Cardiac Arrest; Cognitive Impairment

Summary: the investigators want to investigate the effect of rtms on working memory measured by the n-back task. this is a single case experimental design, abab.

rationale: the survival rate of patients after cardiac arrest and resuscitation has increased considerably. a common consequence of cardiac arrest is ischemic-hypoxic brain damage leading to cognitive impairment. currently, there is a lack of knowledge regarding effectiveness of treatments to improve outcomes of patients with cognitive impairment after a cardiac arrest. objective: the primary objective is to investigate the effects of rtms (itbs protocol) on working memory of people with memory impairments after a cardiac arrest in the past study design: this will be a single blinded replicated randomized sced withdrawal designs study. study population: nine adults who had a cardiac arrest in the past will be participating in this study. they are recruited in the general population. intervention: if participants are suitable based on the screening. participants are invited to the university of maastricht. there they receive intermitted theta burst stimulation with a tms coil for 3 minutes on the dorsolateral prefrontal cortex. then they perform the n-back task for 8 to 12 minutes to estimate working-memory performance. then they have a break (45 min). then they receive 3 minutes of sham stimulation after which they have to perform the n-back task again for 8 - 12 minutes. this will be repeated (active stimulation - sham - active stimulation - sham). main study parameter: the main study outcomes are performance on the n-back task with regard to accuracy. nature and extent of the burden and risks associated with participation, benefit and group relatedness: the participant has to come to the university twice. the screening session takes approximately 1-1,5 hour, the experimental session 3,5 hours. the participant could experience side effects of the rtms, these include: headache, scalp discomfort, tingling or twitching of the facial muscles, and light-headedness. serious side effects are very rare, but they may include: seizures. the n-back task can be experienced as tiring.

Eligibility criteria:
inclusion criteria: * had a cardiac arrest between 3 months and 5 years prior to the experiment session. * scores lower than the general population (corrected for age, education, and sex) on at least one of the cognitive tests ( sd \< -1 on the stroop, digit span, or tmt). * age 18 up to and including 75. * proficient in dutch or english to understand the instructions for the n-back task. * has sufficient understanding to perform the n-back task. * written informed consent exclusion criteria: * has a pacemaker or icd (implantable cardioverter-defibrillator) * a history or a family member with a history of seizures / epilepsy (asked on the phone and checked on the first appointment). * metal implants in or near the head. * pregnancy * any other neurological disorder impending working memory performance besides the ohca.
effect of high protein diet on cardiovascular diseases risk factors among overweight and obese children

Conditions: Body Mass Index Quantitative Trait Locus 7 Disorder; Tangier Disease

Summary: the investigators aimed to determine the effects of hp diet on cvd risk factors among overweight and obese children.

background: studies regarding the effects of high protein (hp) diet on cardiovascular (cvd) risk factors have reported contradictory results. objective: in present study, the investigators aimed to determine the effects of hp diet on cvd risk factors among overweight and obese children. design: in this randomized controlled trial, the investigators recruited 50 overweight and obese women, aged 6-11years into hp or control energy restricted diets for 10 weeks (protein, carbohydrate, fat: 25%, 45%, 30% vs. 15%, 55%, 30%, respectively). total protein amount, divided to animal and plant sources in 50%-50% and animal sources distributed (half/half) between meats and dairy products. fasting blood samples, lipid profile, systolic and diastolic blood pressure and anthropometric measurements were measured based on the standard guidelines.

Eligibility criteria:
inclusion criteria: * bmi \> 85th age of 6-11 years * no history of chronic diseases * no taken medications exclusion criteria: * do not prescribe their diet * mental retardation
chronobiology and childhood obesity in a mediterranean spanish population

Conditions: Obesity; Chronobiology Disorders

Summary: the main objective is to investigate chronobiological aspects of childhood obesity studying the potential relationship between meal patterns and circadian rhythmicity in a cross-sectional sample of obese, overweight and normal weight children/adolescent.

childhood obesity has more than doubled in children and tripled in adolescents in the past 30 y. as consequence, increasingly children and adolescents suffer from elevated blood pressure, impaired glucose tolerance, hyperinsulinemia, dyslipidemia. obesity has a multifactorial etiology since there are potentially numerous contributors to its development and progression. chronobiology, the science that studies periodic (cyclic) changes in living organisms, has been recently proposed as a new and promising topic to investigate. alterations of circadian (24 h oscillations) system may contribute to obesity and its complications development such as high blood pressure, insulin resistance, altered fasting lipid profile. conversely, in a vicious manner, obesity has been regarded as a fault in the circadian system explainable by the association with imbalances and fluctuations of hormones/genes expressions rhythms under the influence of body weight changes. thus, the study will examine changes in circadian rhythmicity over a week period. the primary end point will be to evaluate differences between obese/overweight and non-obese children in chronotypes and the responses of these parameters to meal patterns. in particular, non-invasive measures that are well-established determinants of chronotypes will form the core endpoints for the study. well designed and age-appropriate questionnaires will provide further information in order to study correlations with eating, sleeping and sedentary/active behaviors.

Eligibility criteria:
inclusion criteria: * age: 8-12 years of age * children from schools in the region of murcia (spain) who enter voluntarily exclusion criteria: * children who take melatonin or sleep drugs

Keywords: obesity chronobiology circadian
brief web-based alcohol reduction intervention for undergraduates

Conditions: Alcohol Use; Heavy Drinking; Negative Consequences of Alcohol Use

Summary: tertiary health research intervention via email (thrive; kypri et al., 2009), originally utilized with australian students, is unique in that it contains efficacious components derived from motivational interviewing (e.g., personalized feedback) and cognitive behavioral therapy (protective behavioral strategies), yet is very brief and has established efficacy. this study aims to test versions of thrive tailored to american college students. in addition to replicating original results with thrive, we will also test versions containing unique subsets of protective behavioral strategies to reduce alcohol consumption. the primary hypothesis is that versions of thrive will be associated with lower overall alcohol consumption than an assessment and brief brochure control condition.


Eligibility criteria:
inclusion criteria: * must be a current student at albertus magnus college in new haven, ct exclusion criteria: * under 18 years of age * 25 years of age or older

Keywords: brief intervention web-based interventions computer-based interventions harm reduction young adult college student
comparison of evaporimetry with the established methods of tear film measurement

Conditions: Dry Eye Syndromes

Summary: purpose: to establish whether there is a correlation between dry eye symptoms, age and gender, a difference in symptom intensity in different times of the day, which test (schirmer or tbut) better correlates with dry eye symptoms, whether it is possible to reliably use cheap, easy to use hygrometer in everyday clinical setting, and finally whether there is statistically significant correlation between applied tests (tbut, schirmer and evaporimetry). methods: subjects: 45 in group without dry eye related symptoms, and 45 in group with symptoms. examination included structured case history (questionnaire), slit lamp examination with fluorescein staining, periocular evaporimetry, tbut test and schirmer test.

purpose: the purpose of this study was to establish whether there is a correlation between dry eye symptoms, age and gender, any difference in symptom intensity in different times of the day, which test (schirmer or tbut) better correlates with dry eye symptoms, whether it is possible to reliably use cheap, easy to use hygrometer in everyday clinical setting, and, finally, whether there is statistically significant correlation between applied tests (tbut, schirmer and evaporimetry). methods: subjects were divided in two groups: 45 in group without dry eye related symptoms, and 45 in group with symptoms. examination was performed in the following sequence: 1. structured case history (questionnaire), 2. evaporimetry 3. slit lamp examination with fluorescein staining, 4. tbut test and 5. schirmer test i (without anesthetic, closed eyes) case history consisted of the following questions:irritation more pronounced on wind? irritation during reading and/or watching tv or computer? irritation more pronounced during winter? gritty sensation in the eyes? irritation more pronounced in the morning or evening? all answers, except to the last question, were graded from 0 (no complaints) to 3 (severe). evaporimetry was performed using commercially available hygrometer from hygrotec (titisee-neustadt, germany), installed in swimming goggles with its front part sawn off. first measurement was performed by measuring for 5 minutes with eyes closed. second measurement also lasted 5 minutes, with eyes kept open, normal blinking, and with subject fixating at one point in distance, with no eye movements. measured parameters included: basal φ (%): relative environment humidity before measurement basal t: environment temperature before measurement closed eye φ (%): relative humidity in front of closed eye open eye φ (%): relative humidity in front of open eye c/o: ratio of φ (%) closed/open eye

Eligibility criteria:
inclusion criteria: * patients with or without dry eye symptoms exclusion criteria: * minors * pregnant women * patients with acute eye conditions (inflammation, allergy, trauma) * patients with chronic eye diseases requiring continuous topical treatment (i.e.glaucoma) * ocular surface scarring * patients who did not sign informed consent.

Keywords: dry eye syndromes
safety and effectiveness of agilus (hyaluronic acid) for ankle osteoarthritis

Conditions: OSTEOARTHRITIS

Summary: the purpose of this study is to determine whether agilus is safe and effective in the treatment of mild to moderate ankle osteoarthritis.

the objective of this study is to compare the safety and effectiveness of agilus to a saline injection (control) in the treatment of mild to moderate ankle osteoarthritis. this is a multi-center, randomized, double blind, saline controlled, prospective study with two (2) treatment groups. the active group will receive one injection of agilus per week for three consecutive weeks for a total of three injections. the control group will receive one injection of normal saline per week for three consecutive weeks for a total of three injections. follow up visits will occur at 4 weeks, 12 weeks and 26 weeks following the third injection.

Eligibility criteria:
inclusion criteria: * 18 years or older * chronic, unilateral ankle pain(i.e., in only one ankle) for at least 6 months * diagnosis of ankle oa confirmed by radiographs (x-ray)and clinical exam * are normally active, without aid of mobility devices(such as crutch, walker or cane) exclusion criteria: * have used oral steroids within 30 days (inhaled or topical steroids are acceptable) * have received intra-articular injections of hyaluronic acid in any joint in the last 9 months * have received steroid injections in any joint in last 3 months * have had previous surgery or arthroscopy on the affected ankle in the last 12 months

Keywords: osteoarthritis hyaluronic acid
a comparison of hypnosis and mindfulness on reducing pain in chronic pain patients

Conditions: Hypnosis, Mindfulness Meditation

Summary: the goal of this randomized controlled study is to evaluate the efficacy of an audio session of hypnosis and mindfulness meditation for providing immediate pain relief in individuals with chronic pain from thailand. the main question\[s\] it aims to answer are: • what effects do hypnosis and mindfulness meditation on reducing pain in chronic pain patients? participants will * be randomly assigned to one of the three conditions in 20 minutes: audio hypnosis, audio mindfulness, a control condition * be blind to the study hypotheses. * to keep the experimenter blind, the participants will not reveal what they hear in the audio. * pain intensity will be assessed both at pre- and post-session. * secondary outcomes will be assessed at pre- and post-session by the questionnaires. * post-session quality of sleep will be assessed by telephone interview 1 day after the session. primary outcome: current pain intensity (using a 0 - 10 numerical rating scale) secondary outcome * anxiety at pre and post-session using a 0-10 numerical rating scale * 0-10 numerical rating scale assessing average, worst, and least pain intensity experienced during the sessions * 1-5 categorical scale of treatment satisfaction assessed at post-treatment * quality of sleep using the thai version of the patient-reported outcomes measurement information system-29 (t-promis-29) sleep disturbance section (4 items) at pre-session and 1 day after a session (by telephone interview) * duration of benefit the proposed measures of these variables have all been used successfully in prior clinical trials in samples of individuals with pain from thailand.


Eligibility criteria:
inclusion criteria: 1. being ≥ 18 years old 2. having chronic, non cancer pain (i.e., reporting bothersome pain for at least 50% of the days during the last three months) 3. nociceptive, neuropathic, nociplastic pain characteristic 4. endorsing having current pain intensity of ≥ 4 on a 0 to 10 numerical rating scale 5. being able to read, speak, and understand thai exclusion criteria: 1. having significant hearing loss that would interfere with being able to hear the study audio 2. having significant cognitive dysfunction, physical disability, or severe mood disturbance (e.g., significant anger or high lability) that would interfere with being able to participate in the study procedures 3. cancer-related pain or cancer patients