Kornimate/medical-research-clean huggingface dataset:
cluster randomized controlled screening trial for npc

Conditions: Nasopharyngeal Cancer; Screening; Morality

Summary: this study is aimed to estimate the effectiveness of an epstein-barr virus (ebv) serology-based screening program to reduce nasopharyngeal carcinoma (npc) mortality in a cluster randomized controlled trial in an npc high-risk population. sixteen towns in sihui and zhongshan cities, china will be selected, with eight allocated to the screening group and eight to the control group. cantonese residents aged 30-69 years with no history of npc will be included. residents in the screening towns will be invited to undergo serum ebv vca/ebna1 iga antibody tests.

nasopharyngeal carcinoma (npc) has a high prevalence in southern china. sihui and zhongshan cities are located along the pearl river in guangdong province, china, and are well known for a high incidence of npc worldwide. during the last 20 years, screening for npc has been demonstrated to increase the early detection rate of npc in endemic regions. it is well shown that the effect of epstein-barr virus (ebv) serological antibodies is elevated several years before npc diagnosis; therefore, ebv antibodies have been considered screening markers for npc. however, none of the studies have reported the impact of screening on npc-specific mortality. this study aims to launch a cluster-randomized screening trial with combined vca/iga and ebna1/iga measurement by elisa as the primary screening method in these 2 cities to examine the impact of ebv serological screening on npc-specific mortality. residents aged 30-69 years in eight screening towns in the intervention group will be invited to ebv antibody tests-iga antibodies to ebv vca/iga and ebv nuclear antigen-1 (ebna1/iga) by elisa. the primary objective of this trial is to assess an estimate of the ebv serological antibody-based screening for npc on npc-specific in the populations with a high incidence of npc

Eligibility criteria:
clusters 1. inclusion criteria 1) the town located in sihui or zhongshan city; 2) the town established a tertiary cancer prevention network; 3) the medical staff in the town hospitals agreed to take part in. 2. exclusion criteria 1) having conducted npc screening program. individuals 1. inclusion criteria 1) being aged 30-69 years; 2) being cantonese; 3) having signed the informed consent; 4) having an eastern cooperative oncology group score of 0-2; and 5) having a good physical or psychological condition and consciousness. 2. exclusion criteria 1) having prevalent npc.

Keywords: nasopharyngeal cancer screening early detection mortality randomized control trial epstain-barr virus
pilot study of ono-1101 in patients scheduled for multi-slice ct

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to evaluate the efficacy and safety of ono-1101 in patients scheduled for multi-slice ct.


Eligibility criteria:
inclusion criteria: 1. 20-74 years old 2. heart rate less than 90 beats/min more than 70 beats/min at entering the ct room exclusion criteria: 1. previous allergic reactions to contrast agent 2. renal failure 3. asthma 4. other exclusion criteria as specified in the protocol

Keywords: ono-1101 landiolol hydrochloride multi-slice ct coronary artery disease
multi-arm feasibility study evaluating otx-tp compared to timolol in treatment of subjects with open angle glaucoma

Conditions: Glaucoma

Summary: the purpose of this study is to evaluate how otx-tp, a sustained release travoprost drug product, when placed in the canaliculus of the eyelid compares to timolol drops for the lowering of intraocular pressure (iop) in patients with open angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * subject must be greater than or equal to 18 years of age at screening. * subject must have a documented diagnosis of ocular hypertension, open angle glaucoma. * subject has a mean baseline (day -7 and day 0) hour 0 (t0) untreated iop of ≥ 24 mm hg and ≤ 34 mm hg in each eye, and (t0 + 4h) and (t0 + 8h) iop of ≥ 22 mm hg at baseline visit 2. untreated iop must be ≤ 34 mm hg in each eye at all time points at both baseline visits. * subject has a bcva of 0.6 logmar (20/80 snellen) or better in each eye as measured using an etdrs chart. exclusion criteria: * presence of any uncontrolled systemic or debilitating disease (e.g. cardiovascular disease, hypertension, diabetes, or cystic fibrosis). * punctum size is smaller than 0.4mm or greater than or equal to 1.0mm. * any single iop in either eye at any time point during the screening or either baseline (day -7/day 0) visits of \>34 mm hg.
the impact of premorbid illnesses on the risk of icu admission and short-term outcome

Conditions: Sepsis; Corona Virus Infection; ARDS, Human

Summary: the corona virus disease 2019 (covid-19) pandemic is currently involving all parts of the world. several risk factors for critical illness and death from the disease have been proposed. however, it is still unclear if the observed associations between different comorbidities and chronic medications and severe covid-19 disease and mortality is different from associations between the same factors and other severe diseases requiring intensive care unit (icu) -care. this is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. by combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of covid-19 patients receiving critical care in sweden to a swedish sepsis-cohort and a swedish adult respiratory distress syndrome (ards) -cohort.

the corona virus disease 2019 (covid-19) pandemic is currently involving all parts of the world. several risk factors for critical illness and death from the disease have been proposed. however, it is still unclear if the observed associations between different comorbidities and chronic medications and severe covid-19 disease and mortality is different from associations between the same factors and other severe diseases requiring icu-care. this is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. by combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of covid-19 patients receiving critical care in sweden to a swedish sepsis-cohort and a swedish ards-cohort.

Eligibility criteria:
inclusion criteria: ° individual registered in the swedish intensive care registry (sir) with covid-19 before 27 may 2020. or * individual registered in the sir with severe sepsis or septic chock 2011-2016. or * individual registered in the sir with ards 2011-2016. exclusion criteria: * age below 18 years * individual registered in the swedish intensive care registry without a personal identification number
mri screening for auditory pathway malformations in visually impaired children

Conditions: Visual Impairment

Summary: this pilot study aims to assess the interest to add an auditory pathway morphological analysis during the mri exploration of visual pathway in visually impaired children.


Eligibility criteria:
inclusion criteria: * age \< 18 years old * visual impairment * mri scheduled to explore their visual impairment * parents' informed consent for participation in the study exclusion criteria: * tumoral origin for the visual impairment * no health insurance coverage
pathway for produce prescriptions in diabetes management

Conditions: Type 2 Diabetes

Summary: fruit and vegetable (fv) intake decrease the risk of type 2 diabetes (t2d) and is important for t2d management but is difficult to achieve in adequate amounts for those with a low- income. produce prescription (ppr) projects are an intervention aligned with the social determinants of health that help individuals with a low-income purchase fv by providing an incentive. the impacts of ppr projects on populations with t2d and a low-income is less understood. the multi-level evaluation of produce prescription projects on type 2 diabetes- related outcomes: a pathway to policy change by addressing social determinants of health study will determine the impact of ppr projects on hemo-globin a1c (hba1c; primary outcome), fruit and vegetable intake (fvi), food security, and related behaviors among a diverse sample of ppr participants diagnosed with t2d and low-income (aim 1), and will conduct a cost and cost-effective analysis of ppr projects (aim 2), and a mixed methods process evaluation to understand feasibility and best practices for ppr projects for people with/at risk for t2d (aim 3). we hypothesize that ppr participants will see greater declines in hba1c and improvements in other health and food-related behaviors, compared to the standard of care. we will recruit five gusnip ppr projects, whose healthcare partners serve patients with t2d, and who have participating and matched non-participating control populations. we will collect data at baseline and post-intervention using validated, survey modules, clinical measures, and cost data. five types of data will be used for this project: 1.health and healthcare utilization data from the ehr or point-of-care, 2.participant survey data, 3.qualitative data, 4.program cost data (not human subjects), and 5.process data (not human subjects). information extracted from medical records includes hba1c, weight, and blood pressure and will be collected at 2 time points (months 0,6), following their standard of care protocols. staff will also extract healthcare utilization data (e.g., #primary care and #er visits) from the ehr at each of site. primary analyses will use an intention to treat strategy. analysis will include a linear mixed-effect model to the hba1c with an interaction between group and time to examine whether there is a difference in hba1c trajectories between intervention and control groups. similar models will be used to determine impact on each of the secondary outcomes (e.g., healthcare utilization, bmi).


Eligibility criteria:
inclusion criteria: 1. diagnosed with type 2 diabetes 2. have clinically screened positive for food insecurity and/or be income-eligible to receive medicaid and/or snap-benefits 3. ≥ 18 years of age, and 4. be a patient at a participating healthcare site. exclusion criteria: 1. people who pregnant or nursing and 2. plans to move away during the study period.

Keywords: produce prescriptions social determinants of health food security
metabolic and infectious complications post belatacept conversion

Conditions: Kidney Transplant Infection; Cardiovascular Diseases; Immunosuppression; Kidney Transplant; Complications

Summary: the belaswitch study is a prospective single-centre study including all kidney transplant patients for whom a conversion from tacrolimus to belatacept has been decided by the transplant clinicians of the grenoble alpes university hospital. each patient will be included at the time of conversion (patients stable on tacrolimus for at least 6 months) and will be their own control 1 year after conversion to belatacept. the study has two components: * a "metabolic" benefit arm: the investigators assume that conversion from tacrolimus to belatacept reduces the risk of diabetes by reducing the level of insulin resistance. * an "infectious" risk arm: measurement of the viral load of torque teno virus to assess the state of immunosuppression of patients. in this sense, the investigators hypothesise that it could serve as a biomarker of immunodepression in this population.


Eligibility criteria:
inclusion criteria: * adult patients who have had a kidney transplant more than 6 months ago. * whose immunosuppression includes stable tacrolimus (change in dose or dosage form allowed) for at least 3 months. * therapeutic plan to change tacrolimus-based immunosuppression to belatacept * having signed the consent of collection crb04 - nephrology collection (last authorization number: ac-2019-3627) and the belaswitch protocol consent. exclusion criteria: * subjects under guardianship or deprived of liberty * patients who object to the use of their data and/or samples in the research * patients having received an immunosuppressive treatment different from the standard one (tacrolimus, mycophenolate mofetil or everolimus, corticosteroids) * abo and/or hla incompatible kidney transplantation

Keywords: transplantation belatacept ttv cardio-vascular complications
a musculoskeletal ultrasound program to improve disease modifying anti-rheumatic drugs adherence in rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: non-adherence to medications can lead to sub-optimal treatment in rheumatoid arthritis (ra) patients. in order to improve disease modifying anti-rheumatic drugs (dmards) adherence, the investigators are conducting a randomized controlled trial to test out an intervention to improve medications adherence among low adherers. this intervention involves the use of a musculoskeletal ultrasound program which allows ra patients to visualize their joint inflammation and damage real time while treatment adherence is simultaneously reinforced. in doing so, the investigators hope to improve patients' understanding of their joint disease and motivate the participants to adhere to their medications.

this is a single center randomized controlled clinical trial conducted in the singapore general hospital. eligible ra subjects meeting the inclusion and exclusion criteria will be screened using a medication adherence measure questionnaire. thereafter 132 patients who are low adherers on the questionnaire will then be recruited and randomized (in a 1:1 ratio) to either (a) intervention arm (with musculoskeletal us program) or (b) control arm (without musculoskeletal us program), and followed up over a period of about 6 month.

Eligibility criteria:
inclusion criteria: * male and female patients from 21 to 75 years old * underlying rheumatoid arthritis diagnosed using the 1987 or 2010 ra criteria * on at least one of the following dmards (methotrexate, sulfasalazine, hydroxychloroquine and/or leflunomide) exclusion criteria: * pregnancy
a trial of a cpr video in heart failure patients

Conditions: Congestive Heart Failure

Summary: this is a randomized controlled trial of a cpr video decision aid in patients with advanced congestive heart failure (chf).

aim 1: to compare the care preferences for cpr and intubation among subjects randomized to video and subjects randomized to the current standard of care without the video. hypothesis 1: subjects randomized to the video intervention will be significantly more likely to opt against cpr and intubation compared to those who do not see the video. aim 2: to compare code-status documentation in the electronic medical records between subjects randomized to the video and those who are receiving the current standard of care without the video. hypothesis 2: subjects randomized to the video are more likely to have their code status correctly documented in the electronic medical records compared to those who do not see the video. aim 3: to compare knowledge and decisional conflict of subjects randomized to video and subjects randomized to the current standard of care without the video. hypothesis 3: when compared to subjects randomized to the current standard of care, subjects in the video intervention group will have higher knowledge and lower decisional conflict (lower decisional conflict scores) when asked to choose cpr and intubation preferences.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of advanced heart failure: * new york heart association class iii or iv (iii: marked limitation in activity due to symptoms, even during less-than-ordinary activity; iv: severe limitations, experiences symptoms while at rest). and * two or more hospitalizations for heart failure in the last year. and * either a systolic blood pressure ≤ 120 mm hg or na ≤ 135 meq/l. 2. ability to provide informed consent. 3. ability to communicate in english. 4. age 65 or older.

Keywords: chf
hyperpronation and foot pain

Conditions: Arthritis of Knee

Summary: effects of training and pellots


Eligibility criteria:
inclusion criteria: - exclusion criteria: -
cardiac rehabilitation after coronary artery bypass graft surgery

Conditions: Cardiac Rehabilitation; Coronary Artery Bypass Surgery

Summary: this study aimed to evaluate the effects of cardiac rehabilitation program after cabg surgery on quality of life, sleep quality, anxiety, depression and cardiopulmonary functions.

hypothesis 1: h0: cardiac rehabilitation has no effect on quality of life patients with cabg surgery. h1: cardiac rehabilitation has an effect on quality of life patients with cabg surgery. hypothesis 2: h0: cardiac rehabilitation has no effect on sleep quality patients with cabg surgery. h1: cardiac rehabilitation has an effect on sleep quality patients with cabg surgery. hypothesis 3: h0: cardiac rehabilitation has no effect on anxiety and depression patients with cabg surgery. h1: cardiac rehabilitation has an effect on anxiety and depression with cabg surgery. h0: cardiac rehabilitation has no effect on cardiopulmonary function patients with cabg surgery. h1: cardiac rehabilitation has an effect on cardiopulmonary function patients with cabg surgery.

Eligibility criteria:
inclusion criteria: - patients who had isolated cabg surgery 3 months ago, patients with ef 50% and above, patients who are eligible for the cr program, patients who agree to participate in the study, patients who are 18 years of age and above exclusion criteria: * patients who did not consent to participate in the study, patients who had emergency cabg surgery, patients who had minimally invasive cabg surgery, patients who had repeat cardiac surgery, patients with a disease that was not suitable for the cr program (e.g., stage iv heart failure, unstable angina), patients with ef \< 50%, patients with a psychiatric diagnosis and patients using medications
stem cell therapy for vasculogenesis in patients with severe myocardial ischemia

Conditions: Myocardial Ischemia; Coronary Heart Disease

Summary: mesenchymal stem cells from the bone marrow can be stimulated to differentiate into endothelial cells and participate in the development of new blood vessels in ischemic tissue. the aim of the study is in a phase i/ii safety and efficacy study to evaluate the clinical effect of autologous mesenchymal stem cell therapy in patients with severe chronic myocardial ischemia.

mesenchymal stem cells from the bone marrow can be stimulated to differentiate into endothelial cells and participate in the development of new blood vessels in ischemic tissue. the aim of the study is in a phase i/ii safety and efficacy study to evaluate the clinical effect of autologous mesenchymal stem cell therapy in patients with severe chronic myocardial ischemia. 4o patients with reversible ischemia on a spect will be treated with direct intramyocardial injections of autologous isolated and expanded mesenchymal stem cells.clinical and objective evaluations will be performed at baseline and during 12 months follow-up.

Eligibility criteria:
inclusion criteria: * age 30 to 80 years reversible ischemia on a stress spect angina pectoris ccs class \>_ 2 reduced exercise time \< 10 min no further revascularization options exclusion criteria: * pregnant present or history of cancer proliferative retinopathy systemic severe disease lvef \ ii

Keywords: myocardial ischemia stem cell mesenchymal myocardial perfusion
study on the application of hyperspectral imaging technique in the treatment of imn by tac

Conditions: Idiopathic Membranous Nephropathy; Tacrolimus; Hyperspectral Imaging

Summary: we propose hyperspectral imaging analysis as a method to identify the efficacy of hormone-tacrolimus therapy for pmn, and to classify sensitive and insensitive patients treated with hormone-tacrolimus regimen. a variety of machine learning models were used to prove that hyperspectral imaging technology could assist patients in selecting the optimal treatment plan, and further explore the predictive indicators of pmn treatment effect.

renal biopsy slides of patients with idiopathic membranous nephropathy diagnosed by renal biopsy in our hospital from february 2016 to february 2022 were collected. envi classic software was used to process the hyperspectral images and delineate the region of interest. the one-dimensional spectral data of each pixel in each region were derived. machine learning and deep learning methods were used to analyze the characteristics of hyperspectral data and classify them. the data of the previous study came from the department of pathology and nephrology of qianfoshan hospital in shandong province. under the light microscope, electron microscope and immunofluorescence microscope, the pathological types of glomerular diseases in patients with proteinuria were identified. by scanning the corresponding patient's h\&e stained pathological sections, the hyperspectral microscopic images were classified by machine learning and deep learning methods, and the classification accuracy was greater than 85%. it was concluded that hyperspectral imaging technology can be used as a non-invasive diagnostic method to predict treatment response.

Eligibility criteria:
inclusion criteria: * over 18 years old; * patients with idiopathic membranous nephropathy confirmed by renal biopsy; * had not received hormone and/or immunosuppressive therapy before renal biopsy; * complete clinical data, all signed the "admission certificate of qianfoshan hospital of shandong province", and agreed to use relevant medical information, biological specimen examination and examination results for scientific research. exclusion criteria: * there are factors causing secondary membranous nephropathy, such as immune diseases (systemic lupus erythematosus), tumors/infections (viral hepatitis), drugs or poisons, etc; * severe infection: fever, cough and expectoration, sore throat, abdominal pain, diarrhea, carbuncle and furuncle and other clinical manifestations of skin and soft tissue infection, blood routine white blood cell count beyond the normal range (10×109/l); * severe cardiovascular disease: including chronic heart failure grade 3 or above and various arrhythmias; * infectious diseases: active hepatitis, aids, syphilis, etc. ; * tumor evidence: it has been found that there is a certain tumor or clinical manifestations, tumor markers, etc.,suggesting the possibility of tumor; * patients with follow-up time less than 6 months, incomplete data or missed diagnosis.