Kornimate/medical-research-clean huggingface dataset:
a personalised percutaneous external 3d guide for scaphoid fixation

Conditions: Scaphoid Bone Fracture

Summary: the investigators want to analyse the advantages of using a 3d constructed prototype from a previous ct scan to model an external customised guide por percutaneous scaphoid fixation. the investigators hypothesise that the usage of this device will shorten surgery time, radiation for the surgery team and optimise the percutaneous screw trajectory inside of the scaphoid bone.

to carry out this analysis the investigators will recruit 10 patients who present with an acute fracture of the scaphoid bone type b1 and b2 (herbert classification). a ct scan will be performed and a 3d exoesqueleton model printed, previously deciding the position of the fixation screw inside of the bone and adding a cannulated sleeve in the volar aspect of the exoesqueleton to insert the initial positional guide wire for surgery. surgery time, surgery radiation exposure and screw positioning will be recorded and compared to 10 control patients operated following standard procedure.

Eligibility criteria:
inclusion criteria: * acute scaphoid fracture (herbert b1 b2) exclusion criteria: * concomitant fractures
the effects of arm ergometer endurance training and high-intensity interval training in chronic neck pain

Conditions: Neck Pain

Summary: neck pain is among the causes of morbidity that causes disability. although it is not life-threatening, neck pain is one of the most important reasons for a decrease in the workforce. since there is a close anatomical, musculoskeletal and neural connection between the cervical region and the thoracic spine, neck pain can affect respiratory functions by causing biomechanical changes in the thoracic spine and rib cage. the aim of this study is to investigate the effects of aerobic exercise and high-intensity interval training, which are known to have an effect on both the musculoskeletal system and respiratory functions, on the respiratory parameters and musculoskeletal system disorders and clinical outcomes of people with neck pain when applied with an arm ergometer.

patients will be divided into 3 groups as randomized controlled. aerobic exercise will be applied to the first group and hiit to the second group. the third group will be the control group. the patients in the first group will be applied an aerobic exercise program with an arm ergometer. peak workload will be determined by performing an exercise test with an arm ergometer and training will be given for 60-70% of the peak workload for 45 minutes with arm ergometer 3 days a week for 8 weeks. hiit with arm ergometer will be applied to the patients in the second group. peak workload will be determined by performing an exercise test with an arm ergometer, and hiit will be performed with an arm ergometer for 45 minutes in total, 90-95% of peak workload for 30 seconds, 60 seconds in between, active recovery at 40-50% workload. after the patients receive training for 8 weeks, 3 times a week, post-treatment evaluations will be made. only evaluations will be made twice, with an interval of 8 weeks, for the patients in the control group.

Eligibility criteria:
inclusion criteria: * male and female patients between the ages of 18-55, * having neck pain for more than 3 months, * having neck pain ≥3 cm in a 10 cm vas and * patients with non-specific neck pain who score \> 10/50 on the neck disability index will be included. exclusion criteria: * pregnant women, * smokers, * bmi\>40 * those with any cardiovascular or pulmonary disease, * those who cannot exercise due to any medical condition, * those who have received physical therapy for neck pain in the last 6 months, * red flag (malignancy, spinal fracture, etc.), * spinal fracture, * shoulder fracture, * shoulder subluxation, * cervical or shoulder surgery, * migraine, * rheumatological diseases, * those with cervical root compression syndrome, * those with neurological/inflammatory spinal pathology, * those with chronic whiplash and traumatic neck injury, * persons with \<24 points on the mini-mental test.
open facet joint denervation in the treatment of low back pain

Conditions: Back Pain

Summary: a single blinded rct for adult patients with spine pain. one group had a lumbar laminectomy with denervation of the facet joint at the level decompressed. the other group had a lumbar laminectomy without facet joint denervation. both groups had their back pain and functional limitations measured using a 10 cm visual analogue scale and the oswestry disability index (odi). all measures were taken before surgery and at patients' 6, 12 and 24 week follow-up clinic visit.


Eligibility criteria:
inclusion criteria: * aged 19 or older * a diagnosis of spinal stenosis * having neurogenic claudication * complained of back pain for at least 3 months exclusion criteria: * previous surgery on their spine, * fracture, systemic inflammatory disease, * malignancies or an infection affecting their spine
rct of efficacy and safety of cp003 on cfs/me or post-covid fatigue

Conditions: Chronic Fatigue Syndrome (CFS); Post-COVID ME/CFS

Summary: the goal of this clinical trial is to test if a lingzhi supplement (cp003) helps people with chronic fatigue or post-covid fatigue feel better. it will also check if the supplement is safe to use. the main questions it aims to answer are: does the lingzhi supplement reduce fatigue symptoms? is it safe to take? how does it affect the body's immune system and inflammation? researchers will compare people taking the lingzhi supplement to those who don't take anything (waitlist group) to see if it works. participants will: * take 5 capsules once daily for 6 weeks (or wait to start treatment if in waitlist group) * visit the clinic 2 times for blood tests (before and after taking the supplement) * complete questionnaires 3 times about their fatigue and quality of life (4 times questionnaires for waitlist group)


Eligibility criteria:
inclusion criteria: * meet the fukuda diagnostic definition of cfs/me or have persisting fatigue after the infection of sars-cov-2 * are able to complete a 6-week course of intervention; * able to complete the online validated fatigue surveys. exclusion criteria: * have participated in any type of complements or herbal medicine within the past six months; * have serious medical conditions that might limit their participation in this intervention; * diagnosed with acute inflammation; * are pregnant or are planning a pregnancy in the next 3 months.
implementation of tobacco cessation programming at community behavioral health sites

Conditions: Nicotine Use Disorder; Smoking Cessation; Smoking Cessation Intervention

Summary: the goal of this study is to: partner with respiratory health association and determine barriers and unmet smoking cessation treatment needs from leaders in behavioral health organizations, treatment programs and adults who smoke (aws) in chicago. this will be accomplished by establishing a community advisory board (cab) and pilot testing a community-informed smoking cessation treatment within a community behavioral health organization to determine its feasibility after addressing implementation issues.

the purpose of the proposed study is to determine barriers and unmet smoking cessation treatment needs from leaders in behavioral health organizations, behavioral health treatment providers, and community members in chicago and pilot test a community-informed, targeted rolling smoking cessation treatment within a community organization. the research team and the respiratory health association (rha) will work together to identify community sites that could derive possible benefit from adopting and implementing the targeted treatment. aim 1: develop a community advisory board (cab) comprised of providers, community members, and organization leadership. aim 2: use a mixed-methods approach to understand barriers, facilitators, and unmet treatment needs regarding smoking cessation treatment within the community. aim 3: pilot test the targeted smoking cessation treatment across a 3-month period at one community site through partnership with respiratory health association. hypothesis: the targeted intervention will demonstrate feasibility and acceptability.

Eligibility criteria:
inclusion criteria: * identify as someone who currently smokes combustible cigarettes (at least 1 cigarette per day) on each day for the past month * report interest in quitting cigarettes (at least 6/10 scale in interest of quitting) * age 18 or older, ability to understand the english language, willing and able to provide informed consent * stable residence and contact information throughout the follow up period exclusion criteria: * non-daily or intermittent cigarette use * no interest in quitting smoking * unstable residence/not staying in chicago for duration of study period * current untreated severe substance use disorder (with the exception of tobacco use) or past-year serious untreated psychiatric illness (e.g. schizophrenia, bipolar disorder, obsessive compulsive disorder, unspecified psychosis, past-year suicide attempt)

Keywords: smoking smoking cessation nicotine nicotine use disorder quitting smoking quitting nicotine respiratory health telehealth virtual tobacco tobacco treatment community behavioral health chicago group therapy disparities adults who smoke cigarettes tobacco cessation cessation abstinence substance use substance abuse addiction counseling health counseling health communication
relapse prevention in first episode schizophrenia: a 5 year trial

Conditions: Schizophrenia

Summary: objective: to evaluate the effectiveness of specialised and sustained intervention with or without parent groups during the initial phase of schizophrenia or related disorders on relapse prevention methods: a three conditions randomized trial with a duration of five years participants: 200 consecutively referred patients aged 15-28 years with a first psychotic episode of schizophrenia or related disorder treatment-conditions: specialized treatment of early schizophrenia (st), st including parent groups (st+p) and treatment as usual (tau). outcome-measures: cumulative relapse rates and time to first relapse after first remission. secondary outcome measure: social functioning. statistical analysis: cumulative relapse rates using life-table methods. the effect of the three interventions on time to first relapse after remission will be compared using cox regression analysing intention to treat (itt) grouping.

evidence for optimal duration and necessary ingredients of early and sustained specialized treatment from first episode psychosis till the end of the initial phase schizophrenia is still insufficient. randomized trials with a treatment duration of six months to two years with favorable symptomatic and psychosocial results disappeared at five year follow-up. other studies suggest that specialized treatment should last 5 years in order to be able to prevent instead of only delaying clinical and psychosocial deteriorating. in this study we examine both the symptomatic (relapse) and psychosocial outcome of a three armed five year randomized trial in the initial phase of schizophrenia.

Eligibility criteria:
inclusion criteria: * patients were eligible for the study if they: 1) met dsm-iv-revised criteria for schizophrenia or related disorders, 2) were suffering from a first psychotic episode and 3) were living in contact with parent(s) or other relatives. exclusion criteria: * patients with drug-related psychoses were not included.

Keywords: schizophrenia first-psychotic episode initial phase relapse prevention specialized treatment parent groups social functioning
meditation based lifestyle modification in depression

Conditions: Depressive Disorder

Summary: to evaluate effectiveness of a 8-week behavioral mind-body-intervention based on yoga and meditation in depressive outpatients.

as a contribution to the field of integral medicine, meditation based lifestyle modification (mblm) is a holistic therapy for patients with mental disorders. influenced by ayurveda and yoga, it uses mantra meditation, ethical conduct and healthy life style to promote physical, mental and spiritual health. mblm explains processes within the body and the mind and their relation to diet, exercise, biorhythms, social and personal conduct in an easy but profound way and on an experiential level. besides providing tools for physical, mental and emotional self-regulation, mblm lays ground for personal growth and transcendence of the mind. it is intended to be implemented in groups of patients as well as individual daily training, and because of its modular structure can be adjusted in intensity, duration and weighting of the components according to the specific needs and disorders to be addressed. this makes it also eligible for its potential use in prevention of mental disease and treatment of psychic comorbidities in patients with chronic somatic illness.

Eligibility criteria:
inclusion criteria: subjects must meet the following criteria to be enrolled: 1. outpatients 2. written informed consent by patients who are competent to consent to study participation 3. diagnosis of current mild or moderate episode of depression diagnosed by a consultant psychiatrist 4. male or female ≥18 years of age 5. bdi-ii \>= 10 6. patients must be physically able to perform simple yoga postures and to sit silently for 20 minutes exclusion criteria: patients will be excluded for any one of the following reasons: 1. psychotic symptoms 2. acute suicidal tendencies 3. compulsive disorders 4. cerebro-organic diseases with clinically relevant symptoms 5. severe multimorbidity 6. clinically relevant addictions (tobacco abuse or addiction is allowed) 7. current participation in another trial
ventilation's parameters applied in emergency medicine. a prospective observational study

Conditions: Mechanical Ventilation; Acute Respiratory Distress Syndrome; Protective Ventilation; Survival

Summary: to prospectively assess the mechanical ventilation management when its provided by emergency physicians in french hospital, and to assess complications and outcome of these patients. the study could be measure the proportion of patients developing an acute respiratory failure distress after a take care of by french emergency departments.


Eligibility criteria:
inclusion criteria: * age equal or over 18 years old * needing a invasive or noninvasive mechanical ventilation * mechanical ventilation initiated in prehospital or intrahospital emergency department by an emergency physician exclusion criteria: - age under 18 years old
bar-trial: bioavailability of ethanol following bariatric surgery

Conditions: Obesity, Morbid

Summary: the first-pass metabolism (fpm) is a barrier to the toxicity of ethanol. changes to the size and function of the stomach may alter fpm. bariatric surgery, like the gastric bypass procedure, involves significant changes to the size and function of the stomach and leads to more rapid gastric emptying. consequences will be faster absorption and higher peak concentration of ethanol after surgery than before. there are growing concerns that surgery for obesity in this way may cause alcohol abuse. in this study the investigators compare changes in fpm of ethanol following two different bariatric surgical procedures.


Eligibility criteria:
inclusion criteria: * volunteers from central norway * morbid obese bmi \> 40 kg/m2) * morbid obese bmi \> 35 kg/m2 given a obesity related disease that qualifies for bariatric surgery exclusion criteria: * previous or current alcohol abuse * risk for alcohol harm as assessed by audit * alcohol abstinence * liver disease except fatty liver, which occurs in more than 50% of those who seek bariatric surgery * previous colon resection * not/insufficiently able to informed consent * drugs that interact with alcohol dehydrogenase * drugs that slow down emptying of the stomach * pregnancy

Keywords: bariatric surgery alcohol drinking alcoholism ethanol metabolism
haplo-sct vs asct with or without decitabine in aml cr1

Conditions: Acute Myeloid Leukemia

Summary: a multicentre, prospective, open-label clinical study, including a randomized controlled study in low or intermediate-risk group patients, and a cohort study of maintenance treatment with decitabine after asct.


Eligibility criteria:
inclusion criteria: * age \>= 18y * diagnosed as aml (except acute promyelocytic leukemia m3) for the first time * minimal residual disease (mrd) test can be achieved (molecular biology first if applicatable, and/or cytogenetics and/or immunophenotyping) * presence of an available haplo-mismatch related donor exclusion criteria: * contra-indications of chemotherapy or hematopoietic stem cell transplantation * presence of an available identical sibling donor or a 10/10 hla loci-matched unrelated donor * participating in other clinical trials concerning the prophylaxis of disease recurrence after asct * no effective contraception * pregnant or lactating females * other causes which are not suitable for the trial in investigator's consideration

Keywords: acute myeloid leukemia allogeneic hematopoietic stem cell transplantation autologous hematopoietic stem cell transplantation maintenance treatment hematopoietic stem cell transplantation
covid-19 predictors: safety of gynecological oncology patients undergoing systemic cancer therapy

Conditions: Telemedicine

Summary: we designed a monocenter prospective cohort study using prom via app and remote monitoring via pho-toplethysmography (ppg). the application of these technologies enables an early detection of infections and therefore initiation of medical interventions. the study is conducted as feasibility analysis; primary endpoints are adherence (according to wearing time) and technical robustness.


Eligibility criteria:
inclusion criteria: * gynecological cancer * indication for systemic cancer therapy * patients who are legally competent and able to understand and follow instructions of the study staff * present informed consent exclusion criteria: * no use if internet or applications * persons who are in a dependency or employment relationship with the study center * positive proof of covid-19 * affection of the external auditory canal
a study to evaluate the safety, immune response, and efficacy of gardasil (v501, qhpv) in mid-adult women (v501-019)

Conditions: Healthy Adult Female Participants; Prevention; Papillomavirus Infection; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18

Summary: this study was conducted to assess the safety, immunogenicity, efficacy and long-term effectiveness of a vaccine being evaluated for the prevention of human papillomavirus (hpv) infection and disease in mid-adult women.

the base study vaccination period (v501-019) encompassed day 1 through month 7, during which time participants received randomly assigned, blinded gardasil™ (v501, qhpv vaccine) or placebo at day 1, month 2 and month 6. the base study follow-up period continued through approximately month 48. the base study was extended in protocol v501-019-10 (ext1). participants who received placebo and participants who received only 1 dose of qhpv vaccine in the base study were offered a complete, open-label, 3-dose qhpv vaccine regimen (administered at ext1 day 1, month 2 and month 6). participants who received only 2 doses of qhpv vaccine in the base study were offered a single additional dose of qhpv vaccine (administered at ext1 day 1). participants were followed to ext1 month 7. a long term follow-up (ltfu) extension study v501-019-21 (ext2) was added to observe the long term safety, effectiveness, and immunogenicity of qhpv vaccine in approximately 1,600 women who participated in the base study at sites in colombia. data were collected over a period of 6-10 years following participant's enrollment in the original base study.

Eligibility criteria:
inclusion criteria: * no history of genital warts, vulvar intraepithelial neoplasia (vin), or vaginal intraepithelial neoplasia (vain) * not pregnant and agrees to use effective contraception through month 7 of the study * additional criteria applied exclusion criteria: * pregnant * concurrently enrolled in a clinical study involving collection of cervical specimens * previously received any hpv vaccine * history of severe allergic reaction that required medical intervention * received any immune globulin or blood-derived products within 3 months prior to the first study injection * history of splenectomy, known immune disorders, or receiving immunosuppressives * immunocompromised or diagnosed with human immunodeficiency virus (hiv) infection * known thrombocytopenia or any coagulation disorders that could contraindicate intramuscular injections * history of recent or ongoing alcohol or drug abuse * prior treatment for genital warts, vin, or vain * history of cervical disease (ie, surgical treatment for cervical lesions) * hysterectomy
inflammation and steatosis: the role of alpha-defensin

Conditions: Inflammation; Fatty Liver

Summary: the aim of this study is to examine the correlation between the severity of non-alcoholic steatohepatitis/non alcoholic fatty liver disease (nash/nafld) in naïve and hepatitis c (hcv) positive patients and the amplitude of alpha-defensin immunohistochemical staining in liver biopsy.


Eligibility criteria:
inclusion criteria: * fatty liver disease patients with liver biopsy exclusion criteria: * none
a pilot study of the ckm jumpstart tool

Conditions: Chronic Kidney Diseases

Summary: this is a randomized pilot study to test the feasibility and acceptability of a tool to promote discussion about conservative kidney management (ckm) among older patients with advanced ckd and their providers.

this study is a randomized pilot study to test the acceptability and feasibility of a novel communication tool, called the ckm jumpstart tool, to promote discussion of ckm between patients with advanced ckm and their healthcare providers, the investigators hypothesize that the guide will be feasible and acceptable to patients and their healthcare providers as reflected in greater discussion of ckm between them following use of the tool as compared with usual care. the investigators will enroll 76 patients aged 75 years and older with advanced ckd and their healthcare providers from university of washington medicine and veterans affairs puget sound health care system. patients will be randomized together in a 1:1 fashion to receive the intervention or usual care. data from participants will be collected at the time of enrollment (t1), within 2-weeks of their following clinic visit with their healthcare provider (t2), and approximately 3-month after this clinic visit (t3). the primary outcome measure and measure of feasibility is difference in patient-reported rates of discussion of ckm with a healthcare provider at t2 and t3. the investigators will also evaluate whether provider document in the medical chart of patients whether they had a discussion about ckm with the patient at t2 and t3. the investigators will also collect attrition rates at t2 and t3 as a measure of acceptability. the investigators will further assess user experience of the ckm jumpstart by performing a qualitative analysis of post-intervention interviews with patients and nephrologists, coding for themes elucidating pros, cons and other considerations with using the ckm jumpstart tool and discussion about ckm.

Eligibility criteria:
patients inclusion: * adults aged ≥75 years * advanced ckd as defined as having at least 2 outpatient measures of egfr \ 90 days in the prior year and with at least 1 egfr measure \<20. * english-speaking * receive care from a provider at uw medicine or va puget sound * open to discussing their values and treatment options for kidney disease with their provider. exclusion: * unable to complete the informed consent process * currently receiving maintenance dialysis providers inclusion * their patient is a participant in the study. * are a uw medicine or va puget sound provider or trainee. exclusion • none

Keywords: kidney supportive care communication shared decision-making conservative kidney management palliative care end-of-life care