Kornimate/medical-research-clean huggingface dataset:
using environmental light therapy to improve sleep and neuropsychiatric symptoms in dementia

Conditions: Polypathology and Autonomy Loss

Summary: alzheimer's disease and related syndromes (ad) is a disease affecting memory but also the relationship with the environment and empower people. patients with ad present in 90% of cases of behavioral disorders and of these behavioral disorders include agitation, apathy but also sleep disorders by circadian rhythm impairment.. no study has shown proven efficacy on the behavior of patients with ad. the main objective of the study was to assess the influence of environmental light nighttime sleep of residents.

alzheimer's disease and related syndromes (ad) is a disease affecting memory but also the relationship with the environment and empower people. patients with ad present in 90% of cases of behavioral disorders and of these behavioral disorders include agitation, apathy but also sleep disorders by circadian rhythm impairment. in 2014, the cochrane published a systematic review of the literature over the last 20 years concerning the use of light therapy in patients with a ad. no study has shown proven efficacy on the behavior of patients with ad. the main objective of the study was to assess the influence of environmental light therapy (from 5 a.m to 10 p.m) on nighttime sleep of residents. secondary objectives were the study of sleep time on the day, anxiety by the covi scale and behavioral disorders by the npi scale.

Eligibility criteria:
inclusion criteria: * ehpad residents at les pastoureaux valenton having moderate to severe masa * more than 60 years * presenting motor behavioral disorders and / or anxiety and / or restlessness and / or insomnia . * no underlying acute medical problems including no delirium exclusion criteria: * residents refusing to lend to experimentation * resident who are not matching with the inclusion criteria * total acquired or congenital blindness * bedridden patient ( loss of physical autonomy) * entry to the residence less than 15 days before the start of the experiment.
comparison of a water-soluble topical antimicrobial to silver sulfadiazine in partial thickness burns

Conditions: Burn

Summary: partial thickness burns are a common, painful injury requiring a great deal of resources in their care. silver sulfadizine is a commonly-used topical antimicrobial, but is difficult to remove due to its lipid base. we are comparing a water-based topical antimicrobial therapy to silver sulfadiazine and hypothesize that the water-based therapy is superior in terms of pain control and resources required to deliver care.


Eligibility criteria:
inclusion criteria: * adult inpatients with partial thickness burns exclusion criteria: * superficial or full thickness burns, facial burns, intubated or sedated, pediatric
home-exercise program for children and adolescent survivors of acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia

Summary: * exercise programs in children and teenagers with acute lymphoblastic leukemia (all) strengthens their physical fitness. * exercising improves muscular and functional mobility fitness after finalizing chemotherapy in children and teenagers diagnosed with all. * assess cardiological changes

children and adolescents survivors of all will be randomly assigned to the intervention group and to the control group. a home-exercise program will be designed for 16 weeks with 55 sessions, combining aerobic, strength and flexibility exercises of light and moderate intensity. the following tests will be performed to evaluate the effects of the intervention program: echocardiography, tape treadmill test using a ramp protocol to assess cardiorespiratory fitness, hand grip test to assess muscular grip strength, timed up test and go test (tug) and timed up and down stairs test (tuds) to assess functional mobility, the sit and reach test to assess flexibility and a questionnaire to assess levels of physical activity. the control group will perform their usual physical activity

Eligibility criteria:
inclusion criteria: * the study included of children and adolescents between 7 and 18 years old that were at time in complete remission for a minimum of one year of their neoplastic disease and had finalized their chemotherapy treatments by the time they began the physical exercise program. exclusion criteria: * patients with structural cardiac anomalies, congenital cardiopathies, those in recurrence of their neoplastic diseases, signs of clinical or subclinical cardiac insufficiency and an echocardiography with alterations in systolic and/or diastolic function.

Keywords: cancer physical therapy cardiorespiratory fitness
post market surveillance of sequent please neo with scoring balloon

Conditions: Coronary Artery Disease (CAD)

Summary: the main objective of the sequent® please neo post market surveillance is to assess the clinical suitability of the combination of pre-dilatation using the nse alpha scoring balloon before the use of the paclitaxel-coated sequent® please neo in an 'all comer'/ 'real world' setting for the treatment of in-stent restenosis and de-novo lesions.

the aim of this post market surveillance is to document the safety and efficacy of the drug-coated balloon sequent® please neo in combination with the nse alpha scoring balloon in the treatment of both in-stent restenosis and de-novo lesions in native coronary arteries with reference diameters of 2.5 mm up to 4.0 mm with lesion lengths of 30 mm for procedural success and preservation of vessel patency

Eligibility criteria:
inclusion criteria: * patients with in-stent restenosis and de-novo lesions in coronary arteries exclusion criteria: * intolerance to paclitaxel and/or the balloon coating * allergy to components of the balloon coating * pregnancy and lactation * complete occlusion of the treatment vessel * severely calcified stenosis * cardiogenic shock * risk of an intraluminal thrombus * haemorrhagic diathesis or another disorder such as gastro-intestinal ulceration or cerebral circulatory disorders which restrict the use of platelet aggregation inhibitor therapy and anti-coagulation therapy
effect of combining yoga to tens on diabetic glaucoma

Conditions: Diabetes Mellitus; Glaucoma

Summary: intraocular pressure (iop) is maintained by a balance between aqueous production and outflow with an imbalance leading to elevated eye pressure. very high levels of iop will subject retinal cells to mechanical stress. in addition to mechanical injury, iop elevation can impair ocular blood flow reducing perfusion pressure to retinal neurons. long-term vascular and mechanical stresses can produce further injury at the optic nerve. elevated intraocular pressure (iop) or ocular hypertension (oht) is the only well-established modifiable risk factor for primary open-angle glaucoma (poag), the most common form of glaucoma. glaucoma is a class of optic neuropathy. it is main leading cause of blindness. glaucoma is classified on the basis of anatomic features as open angle (where the anterior chamber angle of the eye remains open) and angle-closure (with closure of the anterior chamber angle). glaucoma is considered primary if the eye has no preexisting disease. secondary forms of glaucoma are caused by various ocular or systemic diseases such as pigment dispersion syndrome and ocular trauma. it seems reasonable to consider that a longer duration of diabetes mellitus (dm) with a prolonged insult to the retina and optic nerve via vascular, glial, and neuronal factors would be associated with a higher risk of oag.

patients with diabetic glaucoma (80 patients ) from both sexes will be divided to 2 groups, 40 patients for each group; study group will receive only one session of 20 minutes yoga ocular training for 20 minutes followed by transcutaneous electrical nerve stimulation (tens) by placing electrodes on skin over urinary bladder (bl) acupoints 61 and 62 for 20 minutes control group will be treated with the same protocol as the study group but with the tens unit is off.

Eligibility criteria:
inclusion criteria: * patients with dm duration more than 5 years . * bmi will be \< 30 kg/m² . * patients with bilateral primary open-angle glaucoma. exclusion criteria: * acute or chronic eye inflammation * cataract * eye surgeries * mental ill patients * patients who will refuse to participate in the study
harmonica playing improves quality of life in patients with copd

Conditions: COPD

Summary: 15 patients who have completed the baylor martha foster lung center pulmonary rehabilitation program at least six months ago will be selected to participate in a 12 week training program with six months of follow up.

subjects will be consented and evaluated prior to beginning the harmonica training. subjects will undergo spirometry testing, six minute walk testing and inspiratory capacity, inspiratory and expiratory respiratory muscle strength will be measured. a music therapist will evaluate their ability to assess the participant's ability to play the harmonica and offer assistance during the training. subjects will complete a self-reported depression, shortness of breath, and quality of life questionnaire. all evaluations and questionnaires will be completed before and after the 12 week program and six months after the training program. they will be trained to play the harmonica and practice as a group during a twelve week program, for one hour a day, one day a week with the instructors, one is a registered respiratory therapist and the other is a music therapist, who will evaluate their ability and offer assistance. the music therapist will meet individually with each study participant at the beginning of the study to assess participants' harmonica playing ability. they are required to practice at home (individually) in between classes for 30 minutes five days a week outside the formal training hour with the group. they may use oxygen as prescribed by their physician during the training. the training booklet includes information to help the subject with copd understand how this program is designed to help them. they will also be given instructions on how to clean the harmonica and infection control measures to use during the program to prevent infections that could occur using the harmonica.

Eligibility criteria:
inclusion criteria: * willingness to attend 12 weeks of harmonica training for one hour a day per week * practice playing at home 30 minutes x 5 days a week * documented diagnosis of copd * ability to perform spirometry, ic, mip, and mep maneuver and 6 minute walk * willing to complete depression, quality of life, shortness of breath, functional evaluation questionnaires * willing to perform in a group setting exclusion criteria: * current copd exacerbation * inability to perform spirometry, ic, mip and mep maneuver * inability to commit to weekly one hour sessions for 12 weeks and practice for 5 days/week.

Keywords: copd shortness of breath harmonica
methylene blue for the treatment of septic shock

Conditions: Septic Shock

Summary: the purpose of this study is to evaluate the efficacy and safety of methylene blue among adult patients with septic shock.

septic shock is a leading cause of morbidity and mortality in critically ill patients worldwide. a potential benefit of methylene blue in the treatment of septic shock has recently been described by estrada. in patients with septic shock, methylene blue initiated within 24 h reduced time to vasopressor discontinuation and increased vasopressor-free days at 28 days. it also reduced length of stay in icu and hospital without adverse effects. in this randomized controlled trial, we aim to evaluate the efficacy and safety of methylene blue on septic shock.

Eligibility criteria:
inclusion criteria: 1. age 18 years old or older; 2. diagnosis of septic shock within 12 h. exclusion criteria: 1. recent intake (4-weeks) of selective serotonin re-uptake inhibitors; 2. pregnant; 3. definitive pulmonary hypertension or chronic pulmonary heart disease; 4. known glucose-6 phosphate dehydrogenase (g-6pd) deficiency; 5. known allergy to methylene blue, phenothiazines, or food dyes; 6. anticipated death from a preexisting disease within 90 days after randomization (as determined by the enrolling physician); 7. refusal of the attending staff or patient family; 8. participated in other study.

Keywords: septic shock methylene blue mortality
musical-animated toys and audio books in pediatric palliative care.

Conditions: Tracheostomy Infection

Summary: the aim of this study was to determine the effect of audio book and musical-moving toy on fear, anxiety and pain in tracheostomy care of children in palliative clinic.

in children with receiving palliative care will be randomly divided into two groups: audiobook group and musical-moving toy. interventions will be applied for 2 days, 1 times a day (2 sessions). no intervention will be applied to both groups besides audiobook or musical-moving toy intervention. the children will be assessed before, during and after. pain, fear and anxiety due to tracheostomy care procedure will be evaluated using the wong baker facial pain scale, child anxiety scale-stateness and children's fear scale . in addition, the heart rate, respiration, blood pressure and spo2 values of the children will be measured with the help of a bedside monitor.

Eligibility criteria:
inclusion criteria: 1. between the ages of 6 months and 18 years 2. receiving inpatient treatment in paediatric palliative care service 3. no visual and hearing abnormalities exclusion criteria: 1. the family's desire to leave research. 2. deterioration of the child's condition

Keywords: palliative care children audiobook musical-moving toy pain fear anxiety
effect of physical exercise on tumor proliferation of luminal b breast cancer patients

Conditions: Breast Cancer; Luminal B

Summary: observational study to evaluate the effect of physical exercise prior to surgery and adjuvant systemic treatment in women with newly diagnosed operable hormone receptor(hr)-positive, human epidermal growth factor receptor 2 (her2)-negative breast cancers

effect of exercise on tumor aggressiveness and the impact on patients' quality of life. exercise is a safe and effective treatment for women diagnosed with breast cancer (bc), that has an integral benefit during and after treatments, however, the effect at the tumour microenvironment it is unknown; previous studies have evaluated the association between exercise and bc, finding a positive influence on it, which suggest that exercise could reduce the aggressiveness of the tumour. this study will explore the exercise impact in tumor microenvironment, as part of the therapy given to the patients prior to surgery and treatment. in addition, different serum biomarkers involved and the tailoring of exercise for these women will be evaluated. the effect of exercise on treatments secondary effects, biomarkers and quality of life will be evaluated after 6 months of bc surgery. this project will open a window of opportunity to explore new translational research as well as new treatment vias to the patients of this breast cancer subgroup.

Eligibility criteria:
inclusion criteria: * histologically confirmed, previously untreated clinical stage i-iiia without previous treatment. * er positive breast cancer according to local results. (rh+ is defined as ≥ 1% assessed by immunohistochemistry (ihc) to estrogen receptor (er) and/or progesterone receptor (p)e). * her2 negative in the primary tumour according to local results. (her2 confirmation should be done following the american society of clinical oncology (asco)/college of american pathologists (cap) 2013 guidelines) * scheduled to undergo surgical resection. * ki67 levels must be over 13%, according to local results. * at least 14 days from enrolment to planned surgical resection. * karnofsky performance status of at least 70% at study entry or 0-1 level in eastern cooperative oncology group (ecog) scale. * signed consent prior to initiation of study-related procedures. exclusion criteria: * schedule to receive any form of induction/neoadjuvant therapy * significant cardiac disease (ventricular ejection fraction of \<50%, unstable angina, placement of cardiac stents and myocardial infarction within precious 6 months) * any pulmonary dysfunction which may affect to the exercise program perform. * any mental disease or condition that compromise the physical, psychological and emotional patients' wellness or affect to the process. * contraindications to a cardiopulmonary exercise test as recommended by the american thoracic society.

Keywords: physical exercise breast cancer
prevention strategies for adolescents at risk of diabetes

Conditions: Type 2 Diabetes; Chronic Disease

Summary: the primary aim of pre-start phase 1 is to pragmatically evaluate and refine a risk assessment tool to identify those children with chronic disease risk factors (including type 2 diabetes).

data will be collected in 5 european commission countries (500 adolescents in total). a range of biological and lifestyle measures will be collected in order to investigate the adolescent's lifestyle and will include body weight and other anthropometric measurements, blood pressure, blood capillary sample, self-reported physical activity, sedentary behaviour and dietary habits. their parent/guardian will complete a number of questions to gather information about variables that have been associated with chronic disease (including type 2 diabetes) and include peri-natal history (birth weight, gestational diabetes), socioeconomic status, family health and medical history. a draft risk tool to identify those children with a 'higher risk' of developing type 2 diabetes in the future has been developed systematic review results and a delphi procedure. this draft tool will be evaluated and refined. this draft risk tool will be evaluated by independent clinical reviewers against the data collected from the 500 adolescent data sets. the results for each adolescent will be independently reviewed by clinicians who will assign either a "lower" or "higher" risk to each case. the results will be compared to the results from the draft 'pre-start tool', used to further refine this identification tool using appropriate statistical methods. the outputs of this study will be a fit for purpose 'pre-start tool' that can be used for recruitment to interventional studies whose primary objective is to reduce the risk of developing chronic disease (including type 2 diabetes) in the future.

Eligibility criteria:
inclusion criteria: * young people aged between 12-14 years of age * be willing and able to give assent * have obtained written parent/guardian consent. exclusion criteria: * are outside the age range of interest (i.e. aged less than 12 years or greater than 14 years of age) * do not have parental consent or do not give assent * have an existing diagnosis of type 1 or type 2 diabetes

Keywords: risk factors screening adolescents
periodontal disease as a risk indicator for erectile dysfunction - a cross-sectional study on 100 patients

Conditions: Erectile Dysfunction; Periodontitis; hsCRP

Summary: background increased levels of c reactive protein (crp) can be found not only within individuals with periodontal diseases and those with atherosclerotic alterations but also have been proved in men with erectile dysfunction (ed). no seems to be the key mediator in the endothelial-derived vasodilation and penile erection. the incidence of ed increases in patients with diabetes, hypertonia, hypercholesteremia, cardiovascular diseases and renal failure. first evidence suggests that there is a relationship between periodontal disease and ed as well. due to slow progression of chronic periodontal disease (0.3-0.5mm attachment loss/year) it can be assumed, that periodontal disease exists mainly before ed develops. specific aims this cross-sectional study aims to assess the incidence of periodontal disease in male individuals with ed. a possible correlation between severity of periodontal disease, level of systemic hs-crp and ed will be assessed. additionally, further risk factors for endothelial dysfunction, such lipid values, will be determined and regarded in the analysis. hypothesis the investigators assume, that severity of ed correlates with severity of periodontal disease as well as with systemic involvement assessed by crp-levels. in detail, the investigators hypothesize, that severity of ed (assessed by the questionnaire "international index of erectile function") correlates with the mean probing depth and the level of systemic hs-crp. material and methods 1. st appointment: in the present cross-sectional study 100 male patients with ed will be included. patients who visit the urological department (rudolfstiftung) for ed-treatment will be asked to participate. the erectile dysfunction will be assessed by means of a questionnaire (international index of erectile function - iief-5). urologic examination. the following blood parameters will be assessed: testosterone, prolactin, hs-crp, tumor necrosis factor (tnf)-alpha, interleukin-1, total cholesterol, ldl, hdl, hba1c and fasting glucose. 2. nd appointment: at the department of oral surgery (bernhard gottlieb school of dentistry) the periodontal situation and the index of decayed-missing-filled permanent teeth (dmft) index of the patients will be determined. a panoramic radiograph for assessment of alveolar bone loss and a periodontal status (probing depth, recession, bleeding- and plaque-indices) will be performed. the observer at the dental clinic will have no information on the severity of the ed (observer blinded).


Eligibility criteria:
inclusion criteria: * male patients with ed defined by an iief-5 score of ≤ 21 * age between 18-45a exclusion criteria: * systemic diseases (e.g. diabetes mellitus, heart disease, hypertension, neurological disorders etc.) * pure psychogenic (non-organic) ed with good spontaneous / nightly erections * periodontal treatment within the last 3 months * antibiotic intake within the last 3 months