Kornimate/medical-research-clean huggingface dataset:
investigation of psycho-physiological parameters in adolescent inpatients with anorexia nervosa

Conditions: Anorexia Nervosa

Summary: a study to assess changes in mental and physical symptoms in adolescent inpatients with anorexia nervosa, a severe eating disorder.

this is a prospective controlled trial to assess changes in psycho-physiological parameters, including eating disorder features (drive for thinness, body dissatisfaction) and comorbid symptoms such as anxiety, depression and quality of life as well as heart rate variability, body warmth and bmi in adolescent inpatients with anorexia nervosa. parameters were assessed at admission, six weeks after admission and three months thereafter and compared to reference values of healthy controls.

Eligibility criteria:
inclusion criteria: * age 11-18 years * restrictive subtype of adolescent an * fulfilling the an diagnostic criteria of the diagnostic and statistical manual of mental disorders (dsm-iv and v) * admitted to the filderklinik for inpatient treatment exclusion criteria: * patients diagnosed with the binge-purge subtype of adolescent an or with other eating disorders * healthy controls: bmi beyond the defined norm for their age group * healthy controls: acute or chronic disorders including psychiatric disorders, heart defects, cardiac arrhythmia, other disorders requiring medication

Keywords: anorexia nervosa eating disorder adolescents inpatient treatment integrative medicine anthroposophic medicine heart rate variability thermography
use of nfant(r) technology feeding system for infants less than 30 weeks ga

Conditions: Prematurity; Extreme Prematurity

Summary: the purpose of the study is to utilize the objective data provided by the nfant® suite of products, along with current nicu visual assessment and cue-based feeding practices, in order to determine if feeding performance outcomes and clinical decision making for individualized feeding plans for premature infants born less than 30 weeks pma are impacted.

will obtain 5 official readings using the nfant(r) technology: baseline between 31 0/7 weeks and 32 0/7 weeks post-menstrual age (pma) with no flow nipple, cue-based feeding readiness reading with no flow nipple no sooner than 33 0/7 weeks pma, post-sequencing reading with extra slow flow nipple, slow flow nipple reading, and standard nipple reading. the technology will also be utilized between readings 2 to 3 times a week. phone follow-up 2 question survey will be administered 21 days after discharge from neonatal intensive care unit.this survey entails routine questions regarding re-admission, to clarify if readmission was within 21 days of discharge, and if the reason for re-admission was feeding related.

Eligibility criteria:
inclusion criteria: * infants less than or equal to 29 6/7 weeks gestation at birth exclusion criteria: * infants 30 weeks or greater gestation at birth * infants with known or suspected congenital anomalies or chromosomal abnormalities * infants with diagnoses known to interfere with oral feeding, including, but not limited to cleft lip. cleft palate, gastroschisis, tracheoesophageal fistula, micrognathia. * history of intraventricular hemorrhage grade 3 or 4 or periventricular leukomalacia * infants with known diagnoses known to interfere with gastrointestinal absorption, including, but not limited to, necrotizing enterocolitis requiring surgical intervention
rehabilitation by multifactorial approach after a latarjet procedure

Conditions: Dislocation Shoulder

Summary: kinesiophobia (fear of physical movement) is common after a previous shoulder dislocation and persists after one year, regardless of the occurrence of a recurrence. this kinesiophobia is associated with a lower level of physical activity and a lower return to sport. increased kinesiophobia, combined with other psychological factors such as depression and fear of re-injury in patients with shoulder instability, results in poor outcomes after treatment. given that there is currently no postoperative protocol that takes this psychological component into account, a new rehabilitation protocol focused on reducing kinesiophobia was recently designed as part of an international consensus study based on the method delphi. this protocol includes a core set of evidence-based interventions aimed at regaining functional stability of the shoulder and reducing fear of recurrent dislocation and kinesiophobia. the goal of this study is to determine if we can reduce kinesiophobia in patients who have undergone stabilization surgery for anterior shoulder instability using this new rehabilitation protocol.


Eligibility criteria:
inclusion criteria: 1. primary or recurrent traumatic anterior dislocation of the shoulder 2. indication of abutment according to latarjet (arthroscopic or open sky) 3. age: 18-67 years 4. understanding of the french language spoken and written 5. written informed consent (in accordance with to ich-gcp guidelines) exclusion criteria: 1. posterior or multidirectional instability of the shoulder (beighton score \>5) 2. age \ 67 years. 3. patients with additional rotator cuff tear. 4. patients with a history of surgery on either shoulder. 5. patients with connective tissue disorders (eg ehler-danlos). 6. patients with (current) anxiety disorders or using anxiolytic medications (eg, antipsychotics) (criterion based on patient record/indications). 7. patients with neurological disorders or systemic disease. 8. patients with inflammatory disease, rheumatoid arthritis or active malignancy. 9. patients previously hospitalized for shoulder pain 10. patients with upper tubercle fracture 11. patients with motor neurological deficit 12. pregnant or breastfeeding patient 13. patient protected under protective measure

Keywords: shoulder instability kinesiophobia latarjet apprehension
photobiomodulation therapy in the prevention and management of chemotherapy-induced alopecia

Conditions: Chemotherapy-induced Alopecia

Summary: this study aims to investigate the effectiveness of photobiomodulation therapy (pbm) in the prevention and management of chemotherapy-induced alopecia (cia). therefore, we hypothesize that pbmt can reduce the severity of cia in gynecological and breast cancer patients, increasing the patient's qol.

the global cancer burden keeps rising, and the accompanied side effects remain a significant concern. this project focuses on one of such complications: chemotherapy-induced alopecia (cia). 65% of cancer patients receiving cytotoxic drugs experience cia, which negatively impacts their qol, as hair loss is often associated with impaired body image and increased depression rates. up to now, prevention of cia is based on scalp cooling, but this treatment has a highly variable success rate. photobiomodulation (pbm) therapy is a non-invasive form of phototherapy that utilizes visible and/or near-infrared light to trigger a cascade of intracellular reactions. pbm can be used to improve wound healing, and to reduce pain, inflammation, and edema. research shows that pbm can stimulate hair growth by increasing the blood flow to the scalp and stimulating the catagen or telogen metabolism of the hair follicle. however, the effect of pbm on cia has not been adequately investigated.

Eligibility criteria:
inclusion criteria: * diagnosed with gynecological cancer (endometrium, cervix, ovarian or vulva) or breast cancer * receiving chemotherapy ((carbo)-taxol) * age ≥ 18 years * able to comply to the study protocol * able to sign written informed consent exclusion criteria: * metastatic disease * pregnancy * active infection of the scalp * previous diagnosis of a hair loss condition * interruption of chemotherapy for more than two consecutive cycles * medication to stimulate hair growth (e.g., minoxidil) * severe psychological disorder or dementia. * inability to speak and understand dutch * substance abuse patients or patients with medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results as judged by the investigator * any condition that is unstable or could affect the safety of the patient and their compliance in the study as judged by the investigator

Keywords: photobiomodulation therapy
effectiveness of a online training program with a clinical procedure standardized in units of nursing (cpsun)

Conditions: Infection Control; Preventive Measures

Summary: this study evaluates if the implementation of an online platform with procedures and protocols, improve the knowledge of professionals and can have a health impact related to decreased contamination of blood cultures.

this is a quasi-experimental study, with parallel groups (experimental and control). the aim of this study is to evaluate the efficacy of an online learning platform used by nurses to improve the results of a blood culture technique. the online learning tool is studied in two of four internal medicine units of a tertiary hospital in madrid. these two units have similar characteristics of personnel, materials and structure. both units are at a great distance, preventing a professional talk to each other.

Eligibility criteria:
inclusion criteria: * be nurse of the nursing unit selected. * foreseeing to remain in service during the study. * acceptance of voluntary participation in the study, prior information. * signature of informed consent. exclusion criteria: * those professionals who for reasons beyond their control are transferred to other services or are on leave (in any form). they can not complete the various phases of the study. * professionals who, for whatever reason, decide to withdraw their consent to participate in the study.

Keywords: nursery care nursery infection online learning
is the degree of perceived effort during resistance exercise important for improvements in blood glucose

Conditions: PreDiabetes; Type 2 Diabetes Mellitus

Summary: the goal of this clinical trial is to compare the degree of effort during a resistance exercise session on blood glucose levels in individuals with prediabetes or type 2 diabetes mellitus. the main questions it aims to answer are: * do individuals with prediabetes or type 2 diabetes mellitus need to perform resistance exercise with a high degree of effort for their blood glucose to improve? * how do they feel (their enjoyment, discomfort) after the sessions with different degrees of effort? participants will perform 3 situations separated by at least 4 days, after being familiarized with all exercises and procedures: * one control day, when they will not exercise; * a high-effort resistance exercise session; * a low-effort resistance exercise session researchers will measure blood glucose levels and psychological responses after these situations to see if the effort was important for the improvement of their blood glucose and how effort affected the way they felt after each situation.


Eligibility criteria:
inclusion criteria: * age between 18 and 75 years; * presence of prediabetes (fasting glycemia between 100 and 125 mg/dl or glycated hemoglobin \[a1c\] between 5.7 and 6.4%) or t2dm (fasting glycemia 126 mg/dl or above or a1c 6.5% or above). exclusion criteria: * renal failure, * liver disease, * uncontrolled hypertension (equal or greater than 160 mmhg systolic and/or equal or greater than 100 mmhg diastolic), * history of severe cardiovascular problems, * in case of oral hypoglycemic drugs usage, being on them for less than 6 months, * inability to perform resistance exercise, * being pregnant or trying to become pregnant during the course of the study, * use of oral contraceptives, * prisoners, * persons requiring a legally authorized representative, * non-english speakers.

Keywords: strength exercise degree of effort glycemic control continuous glucose monitoring prediabetes type 2 diabetes mellitus
observational registry to evaluate real world usage of picso impulse system in stemi patients as part of post-marketing surveillance

Conditions: STEMI - ST Elevation Myocardial Infarction; Anterior MI

Summary: a prospective, multicenter, single-arm, open label registry of commercially treated patients with picso impulse system.

this is a observational registry study. patients with an st-segment elevated anterior infarct eligible for pci and commercial picso treatment will be invited to participate in the picso-ami-iv study. after having given consent as per approved ethics committee requirements, the pci of the culprit vessel should be performed per standard practices. after blood flow restoration, the coronary sinus (cs) will be cannulated through the femoral vein and the picso impulse catheter will be placed in the cs to start the picso therapy. after the procedure the patient will be followed for safety assessments at 30 days, 6 months, 1 year, 2 year and 3 years post index procedure.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years old 2. culprit lesion in proximal or mid lad 3. st-segment elevation 4. pre-pci timi flow 0 or 1. 5. symptoms onset time consistent with myocardial ischemia (e.g. persistent chest pain, shortness of breath, nausea/vomiting, fatigue, palpitations or syncope) ≤ 12 h. 6. patient is deemed eligible for pci 7. consent as per approved national ethical committee specific requirements prior to the procedure. exclusion criteria: 1. patients with contraindications to percutaneous insertion or angiography 2. patients with implants or foreign bodies in the coronary sinus 3. known allergy to polyurethanes, pet or stainless steel 4. known pregnancy or breast feeding 5. known pericardial effusion or cardiac tamponade 6. known central hemodynamically relevant left/right shunt 7. patients with symptom onset \> 12 hours 8. patients with previous cabg 9. patients with a history of stroke, tia or reversible ischemic neurological deficit within last 6 month. 10. patients with coagulopathy 11. patients under judicial protection, legal guardianship or curatorship.

Keywords: picso picso impulse system
pilot study of the effects of resveratrol on endothelial function in subjects with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: observational studies have shown that consumption of grapes and grape products such as red wine is associated with reduced cardiovascular risk. the mechanisms accounting for this benefit remain incompletely understood. resveratrol is a component of grapes and red wine that has favorable effects on endothelial function in diabetic and obese animals. resveratrol is available to people over-the-counter in health food stores and the internet as a dietary supplement. the endothelium plays a central role in the control of blood vessel function. when healthy, the endothelium prevents vasospasm, blood clot formation, and the development of atherosclerosis. endothelial function is abnormal in patients with diabetes mellitus and this abnormality contributes to the development of cardiovascular disease. the present pilot study is designed to test the hypothesis that resveratrol (90 mg/day and 270 mg/day for one week each) will have favorable effects on endothelial function in patients with diabetes mellitus.


Eligibility criteria:
inclusion criteria: 1. male and female subjects. 2. age over 21 years old. 3. body mass index greater than or equal to 25 and less than 35 kg/m2 4. clinically stable type 2 diabetes mellitus. 5. willing to give written informed consent and able to understand, to participate in and to comply with the study requirements. 6. willing to refrain from consumption of red wine, grape juice, and grape products beginning two weeks before and continuing throughout the entire study period. exclusion criteria: 1. women who lactating or pregnant. all women with childbearing potential will undergo a urine pregnancy test at each visit to exclude pregnancy. 2. treatment with an investigational product within the last 30 days. 3. clinically evident major illness of other organ systems, including end-stage cancer, renal failure, or other conditions that in the opinion of the principal investigator make a clinical study inappropriate. 4. liver transaminase levels greater than 3x the upper limit of normal. 5. history of a psychological illness or condition such as to interfere with the subject's ability to understand the requirements of the study. 6. vitamin supplements exceeding two times the recommending daily allowance (rda) within the last 30 days prior to screening. 7. resveratrol, green tea and isoflavone supplements within the last 30 days prior to screening. 8. subjects who practice a vegetarian or vegan diet 9. subjects taking budesonide, buspirone, eplerenone, eletriptan, felodipine, midazolam, saquinavir, sildenafil, triazolam, vardenafil, alfentanil, astemizole, cisapride, cyclosporine, diergotamine, ergotamine, fentanyl, irinotecan, pimozide, quinidine, sirolimus, tacrolimus, terfenadine, or warfarin.

Keywords: endothelium resveratrol diabetes mellitus
systemic pharmacokinetics of bol-303224-a

Conditions: Conjunctivitis, Bacterial

Summary: this is a multi-center, open-label, single dose/multiple dose, pharmacokinetic study in participants with bacterial conjunctivitis. the purpose of this study is to determine the extent of systemic exposure to bol-303224-a following single and multiple topical administration of bol-303224-a in participants with suspected bacterial conjunctivitis.


Eligibility criteria:
inclusion criteria: * must be at least 18 years of age, any race * must have a clinical diagnosis of acute bacterial conjunctivitis and exhibit purulent conjunctival discharge and redness in both eyes * women of childbearing potential must utilize reliable contraceptive methods and have a negative pregnancy test exclusion criteria: * pregnant or nursing women * known hypersensitivity to fluoroquinolones or to any of the ingredients in the study medication * use of any antibiotic within 72 hours of enrollment * participation in an ophthalmic drug or devise research study within 30 days prior to entry in this study
human papillomavirus infection and knowledge and attitudes about hpv vaccines among men who have sex with men (msm)

Conditions: HPV Infection; HIV Infection; Syphilis

Summary: this is a observational study aims to assess anal and genital human papillomavirus (hpv) infection status among men who have sex with men (msm) in china, and their knowledge and attitude about hpv vaccine.


Eligibility criteria:
inclusion criteria: * ≥ 18 years old; * ever had homosexual behaviors in the past 12 months; * willing to take tests for hiv/hpv infection; * physically able and willing to provide written informed consent.

Keywords: hpv msm vaccine china
remote ischemic conditioning in stemi to decrease infarct size

Conditions: STEMI; CAD

Summary: following acute stemi patients may have significant myocardial damage and subsequent heart failure. there is currently conflicting data regarding the benefit of remote ischemic conditioning to decrease the magnitude of infarction. remote ischemic condition is a process where by repetitive intermittent limb ischemia is used to decrease the magnitude of myocardial damage caused by coronary artery occlusion and the subsequent reperfusion injury in stemi patients. remcon-stemi is a multicenter randomized trial to test the impact of remote ischemic conditioning in acute stemi.


Eligibility criteria:
inclusion criteria: patients presenting with stemi within 6 hours of symptom onset and: 1. are expected to receive reperfusion therapy with either fibrinolysis or primary pci. 2. documented informed consent (verbal) exclusion criteria: 1. cardiogenic shock 2. history of anatomical deformity or vascular complication that limit ability to conduct remote ischemic preconditioning
a comparative analysis of ray-tech sponge and ice bag techniques in kidney transplantation

Conditions: Chronic Kidney Disease Stage V

Summary: warm ischemia during kidney transplantation is one of the important factors that negatively affect kidney function in the recipient. the investigators aimed to examine the effects of two techniques (ray-tech sponge technique and ice bag technique) applied to protect the kidney from warm ischemia during kidney transplantation on long-term kidney function.

a prospective, randomized clinical trial was conducted at istanbul okan university hospital, istanbul, turkey. all participants were selected from those who underwent kidney transplantation between january 2020 and january 2023.

Eligibility criteria:
inclusion criteria: -underwent kidney transplantation surgery exclusion criteria: - deceased donor transplantation

Keywords: kidney transplantation warm ischemia
interest of routine screening for hepatitis b and c in patients receiving chemotherapy for solid tumors

Conditions: Solid Tumor

Summary: immunosuppression induced by cancer treatment increases the risk of hepatitis b virus (hbv) and hepatitis c virus (hcv) reactivations. these viral reactivations may be asymptomatic but can cause fulminant hepatitis and death. more, they impact the treatment of cancer by chemotherapy delays or stops. they can occur during cancer treatment but also after stopping, at the immunological rebound. this risk persists for at least 6 months after cessation. the key to the prevention, and the first step, is serological testing. it is also the main problem because international recommendations diverge. hepatologists and infectious disease specialists recommend routine screening hbv of all candidates for immunosuppressive therapy. these recommendations are more implemented by hematologists, given the frequency of hbv reactivation associated to haematological malignancies. clinical oncology societies guidelines suggest a selective screening in case of risk factors of hepatitis b or in patients with a strong immunosuppression (such as anti-cd20 based treatment, stem cell transplantation or lymphoma treatment). the consequence of these differences is a sub-screening by oncologists and the persistence of fatal cases. screening before cytotoxic chemotherapy for solid tumors in countries with low prevalence of hbv and hcv virus is questionable. selective screening of patients at risk hbv and hcv can be assessed.

the aims of the study were : evaluate the seroprevalence of hepatitis b virus (hbv) and hepatitis c virus (hcv) in patients receiving cytotoxic chemotherapy for solid tumors. assess the relevance of screening questions to detect risk factors of hepatitis b virus (hbv) and hepatitis c virus (hcv) and to analyze the patients with superior risk of viral reactivation

Eligibility criteria:
inclusion criteria: * patients receiving chemotherapy for solid tumors in ambulatory medicine unit of the reims university hospital (france) between may 14, 2012 and july 31, 2013