Kornimate/medical-research-clean huggingface dataset:
improving wellbeing of shp personnel at uab

Conditions: Stress, Psychological

Summary: the main objective of this study is to evaluate the impact of a well-being program, sky campus happiness, on well-being of students, faculties, and staff working/studying at school of health professional (shp). shp is leaning on the sky campus happiness (sky) program which is an integrative workshop format that includes both skill-building and group dynamics and may be critical for the effectiveness of the program. sky is a university leadership and well-being program (campushappiness.org) that includes stress-management and tools for psychological resilience: yoga postures, breathing exercises, a breath-based meditation technique \[sudarshan kriya yoga\]. sky also includes positive psychology skills (e.g., gratitude, social connection, acts of kindness, meaning and purpose). in addition, the curriculum includes discussion and application of leadership skills and service learning. relying on existing evidence of previous studies, we hypothesize that participating in this program will increase the well-being of people involved.

students/staff/faculties of shp will be offered to participate in the sky breath happiness workshop followed by participating in a research program designed to study the potential effectiveness of the sky breath happiness program as a stress-management, resilience building wellness tool in this population. they will be given an informed consent form to sign if they choose to participate in the study. the course that the students are enrolled in is the sky program, which is an evidence-based bio-psycho-social program that utilizes a multi-dimensional relationship between biology and behavior. it utilizes a unique set of standardized breathing techniques to rapidly reduce neuro-endocrine stress responses and the autonomic imbalance due to sympathetic overdrive, thus restoring autonomic homeostasis. these are interwoven with coping and stressor appraisal strategies, and simple stretching exercises. classes will be 3 hours long on each of three consecutive days, and participants must be willing to attend all three sessions. there will also be one mandatory one hour follow-up session one week later. participants will be asked to engage in daily 10 to 25 minute home resilience practice sessions performed five days per week. to support participants stabilization of the practices, optional daily guided practice will be offered online at a determined convenient time for all participants to allow full participation. the breathing techniques will be taught by certified instructors.

Eligibility criteria:
inclusion criteria: * healthy students/faculty/staff who at uab, school of health professionals * willingness to complete all study interventional components exclusion criteria: * inability to understand standard english * previous participation in a sky intervention * pregnant persons * diagnosis of bipolar disorder or schizophrenia

Keywords: mindfulness breathing meditation stress reduction sky yoga
buprenorphine group medical visits in primary care

Conditions: Opioid-Related Disorders

Summary: the primary goal of this research is to improve the effectiveness of buprenorphine maintenance treatment (bmt) within primary care. investigators propose that providing bmt as part of a group medical visit (instead of an individual visit) will improve treatment outcomes for patients with persistent opioid abuse, because members become accountable to the group, are exposed to beneficial habits of others (i.e. positive deviance), and can receive efficacious behavioral interventions concomitantly with medical management

investigators have developed a preliminary model of bmt group medical visits, conducted focus groups with bmt patients and providers, and will use this data to develop a manualized group-based bmt intervention (g-bmt). investigators will then conduct a randomized controlled trial (rct) of the g-bmt intervention within primary care to preliminarily test its efficacy, acceptability, and feasibility. participants who have persistent opioid abuse while receiving bmt in primary care will be randomized to the g-bmt intervention (40 participants in 5 groups) or to intensify bmt (treatment as usual) with their individual primary care physician (40 participants). hypothesis: in a 16-week rct of g-bmt, participants who receive the g-bmt intervention (vs. treatment as usual) will have higher abstinence rates (primary outcome, efficacy), fewer hiv risk behaviors (efficacy), and greater satisfaction with treatment (acceptability) and adherence to medical visits (feasibility).

Eligibility criteria:
inclusion criteria: 1. currently receiving bmt at montefiore community health center (chc). 2. received bmt for 12 or more weeks. 3. persistent opioid abuse (positive toxicology for an unprescribed opioid at most recent test or in 50% or more of collected tests in the previous 6 months.) 4. fluent in english of spanish exclusion criteria: 1) pregnancy

Keywords: opioid use disorder group counseling office-based buprenorphine treatment
interest of ultrasound in the diagnosis of severity of lateral ankle sprain

Conditions: Ankle Sprains

Summary: ankle sprain is a frequent and widely trivialized trauma. misdiagnosed or poorly treated, it can recur and thus develop into chronic ankle instability. it can be associated with complications which, if not detected early, can lead to long-term sequelae.

the hypothesis of this study is that ultrasound can better characterize the severity stages of the sprain and can diagnose complications that may have gone unnoticed on physical examination. patients were assessed clinically: demographics, history, clinical examination, functional scores. an ultrasound and an mri were done during the first month to check for complications. the main objective is to assess the value of ultrasound in the diagnosis of the severity of the lateral ankle sprain. the secondary objective is to compare an ultrasound assessment of severity with a clinical assessment and magnetic resonance imaging (mri).

Eligibility criteria:
inclusion criteria: * first ankle sprain with sport or work disability exclusion criteria: * patient with fractures, dislocation or hyperlaxity * previous ankle sprain

Keywords: ankle sprain diagnosis ultrasound mri
cognitive changes and rehabilitation in people with transient ischemic attack, stroke, or stroke risk factors

Conditions: Ischemic White Matter Disease; Transient Ischemic Attack; Mild Stroke; Stroke Risk

Summary: stroke is a leading cause of disability; most strokes (80%) are subcortical, with ischemic damage due to occlusion in penetrating arteries. although ischemic white matter disease (iwmd) may lack gross clinical manifestation, it causes significant cognitive impairment, particularly on measures of executive function, attention, and memory. this impairment is attributable to diffuse damage affecting network connections. while there are many studies concerning rehabilitation of motor function and language in patients with large focal strokes, few studies have addressed attentional and executive functions. to our knowledge, there are no such studies on iwmd. in this study, patients will be randomized to a novel intervention for improving executive function and a control condition matched for therapist exposure. patients will be assessed pre-intervention, post-intervention, and at long-term follow-up using a battery of behavioural and neuroimaging tasks. we predict that the novel intervention will be associated with improved executive function, as assessed behaviourally, and improved frontal network function, as assessed through neuroimaging markers.


Eligibility criteria:
inclusion criteria: * patients with ischemic white matter disease or small vessel disease, who have experienced a transient ischemic attack, mild stroke, or are at risk of stroke * fluent in english * able to provide informed consent to all procedures * sufficient motor and sensory functioning to complete all study components (with correction or assistance as required) exclusion criteria: * substance abuse * other psychiatric condition (other than mood, personality, or behaviour change following onset/diagnosis of white matter disease or related condition mentioned above) * other medical condition suspected to influence cognition

Keywords: cognitive impairment ischemic white matter disease small vessel disease transient ischemic attack mild stroke stroke risk
comparison of dentin hypersensitivity reduction over a 1-month period

Conditions: Dentin Sensitivity

Summary: here we assessed the clinical effectiveness of gluma, fluoride varnish, and the tetric n-bond one-step self-etch system in alleviating dh instantly and over 1 month, after a single topical application.a randomized, double-blind, clinical trial was conducted on 55 patients (25 males, 30 females; age: 20-49 years). seventy teeth were randomly assigned to three groups: gluma (n = 24); fluoride varnish (n = 23); and tetric n-bond adhesive (n = 23). sensitivity to tactile, air blast, and cold stimuli were investigated.. a visual analogue scale was used to assess tactile stimuli, and the schiff cold scale to assess air blast and cold stimuli. dh was evaluated immediately post-treatment, and at the 2-week and 1-month follow-up. between-group and within-group comparisons were made.


Eligibility criteria:
inclusion criteria: * middle-aged adult population who usually complains of dentin hypersensitivity. * age range 20-49 years, that visit the dental hospital at king abdul-aziz university (kaudh) who would have at least one or two teeth with dh * those with recession of the gingiva, teeth erosion or abrasion. * patients agreed to participate in the study. exclusion criteria: * patients going through professional desensitizing treatment during the previous three months; using desensitizing tooth paste in the last two months * chronic; far on progress periodontal disease; treatment for periodontal disease; * teeth with icdas (international caries detection and assessment system) score 4 * teeth diagnosed for irreversible pulpitis; root canal treated teeth * teeth covered with crowns; bridge * teeth with cervical restorations interfering with the evaluation * medically compromised patients currently using medications like anticonvulsants, antihistamines, antidepressants, sedatives or daily analgesics. * pregnant or lactating women; were also excluded.

Keywords: gluma desensitizing agent hypersensitivity
epirus fh reverse cascade screening

Conditions: Familial Hypercholesterolemia

Summary: familial hypercholesterolemia (fh) is the most common inherited metabolic disorder resulting in marked elevations in low-density lipoprotein cholesterol (ldl-c). if left untreated, lifelong exposure to elevated ldl-c leads to a substantially increased risk of premature cardiovascular disease as compared to the general population. although fh adverse cardiovascular outcomes are potentially preventable through early identification of fh individuals and initiation of effective treatment, available evidence shows that fh is under-diagnosed and under-treated. childhood is the optimal period for fh screening, because due to minimal dietary and hormonal influences, ldl-c levels reflect predominantly the genetic component in children and are well suited to discriminate fh from other causes of elevated ldl-c. if fh remains untreated in this latent stage of the disease, individuals show a 10-fold increase of cardiovascular risk during early and middle adulthood. in this context, an effective approach for detecting fh would be a screening during childhood or in young adolescents in combination with reverse cascade screening of first-degree relatives of fh individuals. epirus-fh registry is a model program of reverse cascade screening for fh in children and adolescents in northwest greece that aims to increase public and physician awareness, strengthen the national registry of familial hypercholesterolemia (hellas-fh) and constitute the core for a national fh registry in children and adolescents in greece.


Eligibility criteria:
inclusion criteria: * ldl-c \>160 mg/dl on two seperate measurements 3 months apart * ldl-c \>130 mg/dl + family history of premature coronary artery disease or hypercholesterolemia in one parent * children and adolescents on cholesterol-lowering medication exclusion criteria: * refusal to sign the consent form and disagreement with the terms of participation. * any clinically significant disorder recognized at the time of the preliminary assessment, which in the judgment of the investigator would disqualify patient's participation in the study.

Keywords: children adolescents reverse cascade screening
azilect® in wearing-off (aiwo)

Conditions: Parkinson's Disease

Summary: end-of-dose fluctuations e. g. wearing-off are defined as a recurrence of motor and non-motor parkinson's disease (pd) symptoms that precedes a scheduled dose and improves with the next dose of anti-parkinsonian medication. azilect® is approved and recommended for therapy of wearing-off-/end-of-dose fluctuations and improves motor fluctuations significantly in combination therapy with l-dopa and other parkinsonian medication.

the aim of the non-interventional study is to document efficacy and tolerability of rasagiline as a combination therapy in patients with wearing-off-/end-of-dose fluctuations and the effect of rasagiline on individual wearing-off symptoms, recognized by wearing-off questionnaire 32 (woq-32).

Eligibility criteria:
inclusion: * idiopathic parkinson's disease based on the uk brain bank criteria, * wearing-off / end-of-dose akinesia * at least 18 years old, * written consent to participate in the study. exclusion: * contraindications according to the smpc of azilect®, * treatment with azilect® in the past 3 months and / or * suffering from a relevant cognitive impairment and therefore neither understand the patient information, nor can give their consent to participate.

Keywords: parkinson's disease akinesia azilect® rasagiline combination therapy with l-dopa wearing-off questionnaire-32 quality of life daily practice
metabolomics and breast cancer risk in a nested case-control study of the cancer prevention study-ii nutrition cohort

Conditions: Breast Cancer

Summary: this study aims to investigate diet, lifestyles, serum metabolomics in relation to breast cancer risk in a nested case-control study including 1,547 postmenopausal women from the cancer prevention study ii (cps-ii) nutrition cohort. the cps-ii nutrition cohort is a prospective cohort study of cancer incidence and mortality among 184,185 men and women, established by the american cancer society in 1992. participants completed a self-administered baseline questionnaire in 1992/1993 including demographic, medical, and lifestyle information. follow-up questionnaires were sent to living participants in 1997 and every other year to update exposure information and ascertain newly diagnosed cancers. from june 1998 through may 2001, blood specimens were collected from 21,963 women. all participants completed a short questionnaire and provided informed consent at the time of blood draw. non-fasting whole blood collected from each participant was shipped chilled overnight to a central repository, processed, and frozen in liquid nitrogen at approximately -130 °c for long-term storage. of the 21,963 women who provided a blood sample, investigators identified 782 postmenopausal women diagnosed with invasive breast cancer between blood draw date and june 2011 who had not been diagnosed with cancer (other than nonmelanoma skin cancer) before blood draw or prior to their breast cancer diagnosis. controls were 1:1 matched to cases on date of birth, date of blood draw, and race and were cancer free at the date of case diagnosis. seventeen women who were selected as controls were later diagnosed with breast cancer, at which time they became a case. a total of 1,547 postmenopausal women were included in the breast cancer nested case-control study.


Eligibility criteria:
inclusion criteria: * blood sample * cancer free at blood draw exclusion criteria: * unverified breast cancer * non-invasive breast cancer
assessment of early detection and prognosis based on cfdna methylation in multiple myeloma

Conditions: Multiple Myeloma

Summary: it is an observational, case-control study aimed at early-detection of multiple myeloma and constructing a prognostic model of multiple myeloma. the study will enroll approximately 398 participants including patients with multiple myeloma, patients with benign hematologic disorders and healthy participants.


Eligibility criteria:
inclusion criteria for cancer participants: * age 40-75 years * ability to provide a written informed consent * pathologically confirmed diagnosis of multiple myeloma or highly suspicious cases of multiple myeloma * no prior or ongoing anti-cancer treatment (local or systematic) prior to study blood draw inclusion criteria for benign disease participants: * age 40-75 years * ability to provide a written informed consent * pathologically confirmed diagnosis of benign hematologic disorders or highly suspicious cases with benign hematologic disorders * no prior or ongoing radical treatment of the benign hematologic disorders prior to study blood draw inclusion criteria for healthy participants * age 40-75 years * ability to provide a written informed consent * no cancer-related symptoms or other uncomfortable symptoms prior to study blood draw exclusion criteria for all participants: * insufficient qualified blood samples * recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant * recipient of blood transfusion within 7 days prior to blood draw * recipient of anti-tumor drugs to treat non-cancer diseases within 30 days prior to blood draw, such as rheumatic drugs (methotrexate, cyclophosphamide, or azathioprine), or endocrine drugs (tamoxifen) additional exclusion criteria for cancer participants: • other current malignant diseases or multiple primary tumors additional exclusion criteria for benign disease participants: • current or history of malignancies additional exclusion criteria for healthy participants: * recipient of anti-infectious therapy within 14 days prior to study blood draw * prior or ongoing treatment of cancer within 3 years prior to study blood draw * current autoimmune disease or clinically significant or uncontrolled comorbidities

Keywords: multiple myeloma early detection liquid biopsy
assessment of eyeart performance with retinal imaging devices

Conditions: Diabetic Retinopathy

Summary: the study evaluates the performance of the eyeart system for detecting diabetic retinopathy from images captured using multiple retinal imaging devices and operators.


Eligibility criteria:
inclusion criteria: * a diagnosis of diabetes mellitus; * understanding of study and provision of written informed consent; and * 22 years of age or older. exclusion criteria: * persistent visual impairment in one or both eyes; * history of macular edema, severe non-proliferative retinopathy, proliferative retinopathy, or retinal vascular (vein or artery) occlusion; * history of ocular injections, laser treatment of the retina, or intraocular surgery other than cataract surgery without complications; * subject is contraindicated for fundus photography (for example, has light sensitivity); * subject has contraindications for mydriatic medications or is unwilling or unable to dilate; * subject is currently enrolled in an interventional study of an investigational device or drug; or * subject has a condition or is in a situation which in the opinion of the investigator, might confound study results, may interfere significantly with the subject's participation in the study, or may result in ungradable dilated fundus photographs.
mri imaging of ipsilateral retromuscular access

Conditions: Hernia, Incisional

Summary: the aim of this study is to measure the mesh shrinkage and the visualization of the mesh with mri scan at 1 month and 13 months after robot assisted retromuscular incisional hernia repair with ipsilateral access and the use of the visible cicat mesh (dynamesh®) for defect repair. the investigators also want to measure the volume of the rectus muscles and the change between 1 and 13 months.

the aim of this study is to measure the mesh shrinkage and the visualization of the mesh with mri scan at 1 month and 13 months after robot assisted retromuscular incisional hernia repair with ipsilateral access and the use of the visible cicat mesh (dynamesh®) for defect repair. the investigators also want to measure the volume of the rectus muscles and the change between 1 and 13 months. possibly the ipsilateral retromuscular access could induce some atrophy of the rectus muscles. the study will be conducted in the department of surgery in het az maria middelares, ghent, belgium. dr. filip muysoms will personally select and operate all patients eligible for this study. dr.muysoms will inform all patients about the surgery and the follow-up with mri scan thereafter. dr. beckers and dr. heindryckx will perform all mri examinations of the patients at 1 month and 13 months post-operatively and will be available for questions from the patient. the investigators want to show that with this type of mesh it is possible to visualize the mesh after retromusculare placement in vivo in a safe manner. furthermore, the positioning of the mesh, mesh shrinkage or mesh shifting will be monitored with this technique. this provides long-term benefit and provides early treatment possibilities in case of post-operative complications related to the mesh position.

Eligibility criteria:
inclusion criteria: * 20 patients selected and operated by pi. exclusion criteria: * \<18 years * emergency surgery (incarcerated hernia) * clean-contaminated, contaminated or dirty procedures (according to the cdc classification) * lateral hernias * hernias that need a component separation technique. * previous mesh repair on the midline * asa score\> 4 * pregnancy * no patient informed consent * life expectancy of less than 2years * contraindications for mri