Kornimate/medical-research-clean huggingface dataset:
dose escalation using hypoxia-adjusted radiotherapy

Conditions: Head and Neck Squamous Cell Carcinoma

Summary: de-hyart is a phase ii clinical trial aimed at understanding the effects of escalating radiation doses to hypoxic sub-volumes inherent to squamous cell head and neck cancer. the study is aimed at assessing locoregional control, feasibility, and acceptable toxicity with such a strategy.

de-hyart is a randomized, non-blinded study that assesses the effects of combining imrt (using sib-sequential planning) with dose-escalation to hypoxic sub-volume delineated using \[18-f\] fmiso. the treatment protocol will also include concurrent chemotherapy with cisplatin at standard uniform dosing. patients with hnscc whose cancer is determined to originate from the oral cavity, oropharynx, larynx, and hypopharynx will be selected. the included patients will be subjected to \[18f\] fmiso scan, labeled as baseline fmiso. depending upon the result of the baseline fmiso, the patient will be either hypoxic or anoxic. patients exhibiting no hypoxia in their tumor will be labeled as arm 1 and act as an external cohort. patients with hypoxia will be randomized (1:1) into two arms - arms 2 and 3. both arms will be subjected to chemoradiation by imrt and concurrent chemotherapy with cisplatin at 40mg/m2. in arm 3, the trial arm will receive an additional 10 gy @ 2 gy per fraction in phase ii (total 80 gy) to the hsv + 5mm isotropic margin. one twenty-four patients will recruited in a 1:1 fashion between arm 3 and arm 2. the primary endpoint will be locoregional control and its possible increase in control.

Eligibility criteria:
inclusion criteria: * age: 18 - 70 years * willingness to sign informed consent (written/video documentation) * performance status: ecog 0 - 2 * histology proved - squamous cell carcinoma * any grade, gender * tumour sites: oral cavity, oropharynx, hypopharynx and larynx * sufficient bone marrow reserve within the last 14 days. * hb: \> 10g/dl (corrected) * tlc: \> 4,000 per cumm * platelet: \>1.5lakh per cumm * liver functions and kidney functions within normal limits * nutritional and dental assessment before inclusion into the study exclusion criteria: * hpv (p16) positive tumours * prior surgery and/or radiation therapy given for any hnc * t1/t2 glottis * metastatic disease or disease not amenable for definitive locoregional treatment. * medical co-morbidity hampering the administration of radiation and/or chemotherapy (cisplatin) * pregnancy or lactation
the effect of virtual reality on anxiety during vasectomy

Conditions: Vasectomy; Virtual Reality

Summary: the primary purpose of the study is to determine if the use of virtual reality (vr) goggles reduces the degree of anxiety patients experience during vasectomy procedures. the eligibility criteria include a.) appropriate age (19-100 years); b.) undergoing elective vasectomy procedure for purpose of desired sterility; c.) acceptance of wearing goggles; d) able to provide informed consent.there will be two groups, group a will wear vr goggles and group b will not. evaluations will be done by survey to include questions regarding the level of anxiety experienced during the procedure, along with satisfaction scores of the experience.

1. the aim of the study is to evaluate the efficacy of virtual reality goggles (vrg) for improving the patient's experience during vasectomy procedure. 2. the secondary aim is to determine if vrg reduces the level of anxiety experienced during vasectomy procedure. vr is an immersive, multisensory experience in a three-dimensional environment designed to replicate a real world. it has been shown in multiple studies to decrease acute and chronic pain in a variety of clinical settings. the mechanism is due to distraction by activating visual, auditory and proprioceptive senses. one example of this is a report by g. pooja et. al. where in vr goggles reduced pain and medication use during orthopedic procedures (1). another study found decrease in pain in medically treated patients (n=50 patients in 2 groups) after a 15 minute vr viewing on pain reduction compared to 2 -d viewing (2).

Eligibility criteria:
inclusion criteria: 1. appropriate age range (19-100 years) 2. undergoing elective vasectomy procedure in the urology clinic 3. willing to sign consent to participate in the study exclusion criteria: 1. visually impaired (blind) 2. 18 years of age or younger 3. subjects under the influence of medications will not be approached regarding study participation.
the influence of infant feeding type on preterm infant's intestinal microbiome

Conditions: Microbial Colonization

Summary: this study aims to examine the factors associated with preterm infant's intestinal microbiota depending on feeding type (breast milk or preterm formula)

the gut microbiome has been increasingly found to affect human health. feeding plays an important role in determining the composition and diversity of the neonatal gut microbiome. preterm infants are at a high risk of gut microbiota disruption and dysbiosis because of physiological immaturity and environmental factors. in preterm infants, breast milk has been associated with improved growth and cognitive development and a reduced risk of necrotizing enterocolitis and late onset sepsis. the objective of study is to determine the impact of feeding type on gut microbiome of very preterm infants admitted in a neonatal intensive care unit (nicu). meconium and the additional 2 fecal samples will be collected from preterm infants. fecal samples will be collected every 14 days, during 28 days, from diapers into sterile tubes. dna will be extracted from fecal samples and different bacterial genus and species will be analyzed. the type of infant feeding (breast milk or preterm formula) is recorded daily to classify the type of infant feeding received during the 14 days prior to each fecal sample collection.

Eligibility criteria:
inclusion criteria: - very preterm infants (\< 32 weeks gestational age) admitted in the nicu of cha bundang medical center within the first 24 hours after birth exclusion criteria: * parents refuse to participate/sign informed consent * major congenital anomalies

Keywords: intestinal microbiota very preterm infant breast milk preterm formula
physical activity and fertility care study

Conditions: Infertility, Female

Summary: randomized control trial to determine if performing the us health and human services recommended amount of weekly physical activity during ovarian stimulation will differentially affect mental health or clinical outcomes of individuals who are usually active, insufficiently active, or inactive in their everyday lives. the goal overall is to assess for safety and value of physical activity during fertility treatment.

consenting participants will be separated into groups based on current average level of physical activity: active women (complete \>75 minutes of vigorous exercise or \>150 minutes of moderate exercise per week) and insufficiently active women (\<75 minutes of vigorous exercise or \<150 minutes of moderate exercise per week). between time of study enrollment and first ultrasound at start of ovarian stimulation cycle, the participants will be sent a link to questionnaires to assess general mental health parameters and physical fitness. they will be asked to complete the questionnaire prior to first ultrasound visit. at time of first ultrasound, participants who have completed the pre-stimulation survey will be randomized into one of two arms depending on their group: the active group will be randomized to (a) maintenance or (b) decreased activity arm, and the insufficiently active group will be randomized to (c) increased or (d) maintenance activity arm. also at first ultrasound, participants will be given a wearable heart rate monitor in order to track heart rate during the time from ovarian stimulation to first pregnancy test in order to monitor compliance to randomized activity level of each participant. the data from the monitors will be collected through a central university provided, password protected laptop utilizing an app platform. furthermore, all participants will be asked to complete a daily mood, stress, discomfort questionnaire throughout stimulation. participants will be expected to continue recommended physical activity level and questionnaires until day of egg retrieval. wearable monitors will continue to be worn until time of first pregnancy test. within the two weeks after completion of egg retrieval, participants will be sent a follow-up questionnaire to assess overall treatment stress and satisfaction with ovarian stimulation cycle. those who completed in vitro fertilization and fresh embryo transfer will be sent a second follow-up questionnaire about 1-2 weeks after pregnancy test.

Eligibility criteria:
inclusion criteria: * first ovarian stimulation cycle for egg freezing or for in vitro fertilization * english speaking/reading * patient at the center for reproductive health, university of california san francisco exclusion criteria: * serious health conditions that limit amount of physical activity * bmi\>40

Keywords: physical activity in vitro fertilization ovarian stimulation exercise
mycetoma retrospective data collection

Conditions: Mycetoma

Summary: the goal of this retrospective observational study is to describe mycetoma cases detected in health care facilities in india and senegal in a 10-year period. the main objectives are to: * determine the number of mycetoma cases diagnosed per year and trends over time. * describe characteristics of diagnosed mycetoma cases. 1. describe demographic characteristics of patients with mycetoma. 2. describe clinical characteristics of patients with mycetoma upon initial presentation and over time. * assess etiology of mycetoma cases. * characterize clinical management of mycetoma cases. 1. characterize approaches to diagnosis of mycetoma. 2. investigate types and durations of treatments (including medical and surgical approaches) utilized to treat mycetoma cases. 3. describe clinical outcomes among patients with mycetoma. the study team will review all available medical, laboratory and radiologic records of identified mycetoma cases and use data collection forms to extract relevant data.

mycetoma is a poorly understood neglected tropical disease which disproportionately affects the poorest of the poor and is associated with substantial morbidity. the disease presents a multitude of diagnostic and management challenges; in particular, effective treatments for eumycetoma, the fungal and least understood form of the disease are lacking. dndi and partners aim to conduct late-phase clinical trials on a promising new pharmacologic treatment for eumycetoma, but substantial knowledge gaps preclude such trials. these knowledge gaps include data on the burden, distribution, causative agents, clinical presentation, natural history, and common approaches to diagnosis and treatment of mycetoma in endemic countries. this study, a retrospective review of mycetoma cases, aims to generate such data from several countries suggested by preliminary data to potentially be good candidate clinical trial sites.

Eligibility criteria:
inclusion criteria: * any patient given a diagnosis of mycetoma in a medical, radiologic, or laboratory record. exclusion criteria: * patients with illegible or inaccessible health records.
concurrent laparoscopic hysterectomy and weight loss surgery in obese patients with endometrial carcinoma or endometrial intraepithelial neoplasia

Conditions: Endometrial Carcinoma; Obesity; EIN; Endometrial Intraepithelial Neoplasia; Endometrial Cancer Stage I

Summary: to assess the feasibility of an expedited referral process for the obese endometrial cancer or ein patient from her gynecologic oncologist to the brigham center for metabolic and bariatric surgery (cmbs) in order to undergo concurrent weight loss surgery and hysterectomy within 8 weeks of first appointment with a gynecologic oncologist (or 12 weeks for ein patients).

the most common risk factor for endometrial cancer is obesity. however, because early-stage endometrial cancer has a very high survival rate, patients more often suffer from long-term issues related to their weight, like heart disease, stroke, and diabetes. weight loss surgery has been shown to help patients lose weight and also decrease their risk for obesity-related diseases. this research study is a feasibility study. this is the first-time investigators are studying both 1) the referral process of patients with endometrial cancer to the center for metabolic and bariatric surgery without delaying curative treatment of endometrial cancer 2) the combined surgery of both hysterectomy and weight loss surgery. the combined surgery of hysterectomy and weight loss surgery has been performed both at this institution and others without increased complications, but it has not been formally studied. approximately 30 patients are expected to participate in this study at brigham and women's hospital (bwh).

Eligibility criteria:
inclusion criteria: * female adults at least 18 years of age * a bmi of 35-39.99 and 1 or more severe obesity-related co-morbidities --including t2d,112 hypertension, hyperlipidemia, obstructive sleep apnea (osa), obesity-hypoventilation syndrome (ohs), pickwickian syndrome (a combination of osa and ohs), nonalcoholic 4 fatty liver disease (nafld) or nonalcoholic steatohepatitis (nash), pseudotumor cerebri, gastroesophageal reflux disease (gerd), asthma, venous stasis disease, severe urinary incontinence, debilitating arthritis, or considerably impaired quality of life) or a bmi ≥ 40 * tissue diagnosis (usually endometrial biopsy) of grade 1 endometrial carcinoma or ein. exclusion criteria: * younger than 18 years old * bmi \< 35 * without a tissue diagnosis, or with a grade 2 or greater endometrial cancer tissue diagnosis * pregnant participants will be excluded from this study. * patients with contraindications to bariatric surgery will also be excluded. --this includes active smokers, prior bariatric surgery, active substance abuse, recent suicide attempt, bulimia nervosa, large abdominal hernias, or poorly controlled psychiatric illness * include inability to read an english informed consent form, and unwillingness to provide informed consent.

Keywords: endometrial carcinoma obesity ein endometrial intraepithelial neoplasia endometrial cancer stage i weight loss surgery bariatric surgery
evaluation of the effect of three types of rapid maxillary expanders (conventional, hybrid and mse)

Conditions: Maxillary Retrusion; Nasal Airway Obstruction

Summary: aim of the study: to compare radiographically the morphometric changes in the nasal airway after using three types of rapid maxillary expansion (rme) conventional hyrax (ch), hybrid hyrax (hh) and maxillary skeletal expander (mse) using cone beam computed tomography (cbct).

abstract aim of the study: to compare radiographically the morphometric changes in the nasal airway after using three types of rapid maxillary expansion (rme) conventional hyrax (ch), hybrid hyrax (hh) and maxillary skeletal expander (mse) using cone beam computed tomography (cbct). material and methods: a total sample of thirty cbct of patients presented with constricted maxilla with mean age of 14±3y was randomized in to three groups. group 1 ch, group 2 hh and group 3 mse. cbct records were taken before(t1) and after six months (t2) of rme; the airway was segmented and quantified using software (version 5.3.4.39usa).

Eligibility criteria:
inclusion criteria: * patients suffering maxillary collapse with a skeletal background * patients with unilateral or bilateral posterior crossbite. * patients with reduced or average anterior face height. * patients with no periodontal disease. * patients with good oral hygiene and general health. * no systemic diseases that may affect bone quality or interfere with orthodontic treatment. * patients with erupted maxillary permanent first molars and premolars. * patients with no previous orthodontic treatment. exclusion criteria: * previous treatment * syndromes * cleft lip and palate
volumetric magnetic resonance imaging in dementia

Conditions: Dementia; Alzheimer Disease

Summary: dementia is a term for the impaired ability to remember, think, or make decisions that interferes with doing everyday activities. alzheimer's disease is the most common type of dementia. though dementia mostly affects older adults, it is not a part of normal aging. this study aims to assess the role of volumetric mri in evaluation of different types of dementia.

neurocognitive disorders (dementia) are prevalent clinical problems. with the increase in average life expectancy, its prevalence is rising at an alarming rate. in 2005, an estimated 24 million people around the world suffered from dementia, and that number is expected to double every 20 years. by 2040, it is predicted that over 81 million people worldwide will suffer from dementia. most experts agree that treatment will be most beneficial if applied early, before significant, potentially irreversible neurodegeneration and functional impairment has occurred. clinical symptoms of most subtypes of dementia arise from progressive neuron and synapse loss, with the resulting tissue atrophy. brain magnetic resonance imaging (mri) is regularly used in diagnosing dementia as it visualises the structural changes caused by neurodegeneration. it is key in defining subtle differences between healthy and pathological cerebral volume loss and between dementia subtypes. visual assessment of brain atrophy patterns is commonly supported through the use of visual rating scales. however, these scales have a subjective element and their application relies heavily on the prior experience of the radiologist using them. and they have poor sensitivity to subtle or prodromal changes and have ceiling and/or floor effects. application of quantitative volumetric reporting tools, which automatically quantify an individual patient's regional brain volumes and compare them to healthy populations, can potentially help in interpretation of the severity and distribution of brain atrophy and contextualize their findings by referencing normative brain volumes in healthy populations. this will improve the accuracy of radiological diagnosis of different subtypes of dementia

Eligibility criteria:
inclusion criteria: * patients with any type of dementia. * patients with mini mental state examination equal or more than 18. exclusion criteria: * patients with contra-indications to mri.
heart failure study: the atlanta cardiomyopathy consortium

Conditions: Heart Failure

Summary: heart failure is a very common cause of hospital admission and there are half a million new cases diagnosed each year in the united states. while some important progress has been made over the last two decades for the treatment of heart failure, there still remains a critical need for further advances in our understanding of this disease in order to significantly improve patient outcomes. large numbers of heart failure patients need to be studied over time to allow scientists to investigate those factors that influence the responses to therapy.

in this study information will be collected on patients with heart failure and their progress and outcomes will be followed over time. the aim is to understand the natural history, risk factors for improvement or progression, and determinants of response to therapy for heart failure. of interest are many aspects of heart failure including genetic influences, quality of life issues, how individuals cope with feelings about having heart disease, and how they manage their day-to-day symptoms etc.. a database will be created of approximately 1,000 heart failure patients from emory, emory university hospital midtown, wesley woods, grady, and the va medical center. this is strictly an observational study and subjects will not be receiving any experimental therapy nor will their routine medical care be affected in any way. data to be collected includes: 1. medical history of the patient 2. medical history on the patient's family 3. survey data including health behaviors \& psychosocial variables 4. blood \& urine samples 5. ekg 6. six minute walk test 7. hand grip strength after collecting data, a variety of statistical tests will be run to analyze factors that influence heart failure patients' responses to treatment. the results of this analysis will be used to optimize therapy for future heart failure patients.

Eligibility criteria:
inclusion criteria: * age: 18 years and over * sex: both * ethnic origin: all * diagnosis required to participate: clinical diagnosis of systolic or diastolic heart failure exclusion criteria: * congenital heart disease * previous heart transplantation * no primary infiltrative disease i.e. amyloidosis

Keywords: cardiomyopathy, heart failure, dna, echocardiography, messenger rna, natural history
complications related to vascular access devices in home parenteral nutrition patients

Conditions: Vascular Access Complication

Summary: central vascular access devices are required for home parenteral nutrition (hpn). there is few data available concerning their complications in adult hpn patients, and the potential link between venous thromboembolism and catheter infection is not well established. the aim of this prospective cohort study is to compare the incidence rate of catheter related complications among 3 types of central vascular access: peripherally inserted central catheters; tunneled catheters and port-a-cath devices, in adults patients on hpn; describe the risk factors, and identify a potential link between venous thromboembolism and infection. more than 300 patients will be consecutively enrolled and followed up from the time of catheter insertion until its removal. venous complication (identify by an ultrasound examination if deep vein thrombosis is suspected), infection related to catheter and mechanical complications will be analyzed. the incidence of complications will be expressed per 1000 catheters-day and or as a percentage of total catheter.


Eligibility criteria:
inclusion criteria: * adult patients * having a catheter insertion during the study periode * at the unit of vascular access of lyon sud hospital * for parenteral nutrition * from july 1st, 2017 to june 30, 2020 exclusion criteria: * catheter inserted in intensive care unit * for other treatment (chemotherapy, antibiotic)

Keywords: central venous access device catheter-related complications venous thromboembolism catheter-related bloodstream infection peripherally inserted central catheters home parenteral nutrition
4d velocity mapping of the heart in rtof patients

Conditions: Magnetic Resonance Imaging; Tetralogy of Fallot

Summary: mri with 4d flow permits to assess the hemodynamic parameters in a parent vessel and its branches inside the same sequence.

mri with 4d flow permits to assess the hemodynamic parameters in a parent vessel and its branches inside the same sequence. the objective of the project is to compare the regurgitant fraction in the pulmonary artery (pa) measured using 4d mr-flow and standard 2d mr-flow in repaired tetralogy of fallot (rtof) patients. the consistency of the 4d flow quantization will be assessed assuming mass conservation in the pulmonary artery tree (pa flow =leftpa flow +rightpa flow ? ).

Eligibility criteria:
inclusion criteria: * tetralogy of fallot patients * referred for clinical mri examination * ≥ 15 years exclusion criteria: * anyone with a classic contraindication to mri * severe obesity * gadolinium chelate allergy * \< 15 years * counter-indication to mri examination * vulnerable person

Keywords: phase-contrast mri blood flow velocity mapping quantitative mri cardiac imaging tetralogy of fallot