prospective collection of surplus surgical tumor tissues and pre-surgical blood samples

Conditions: Breast Cancer; Colorectal Cancer; Lung Cancer; Prostate Cancer; Hematologic Cancer

Summary: the study is intended to collect specimens to support the application of genome analysis technologies, including large-scale genome sequencing. this study will ultimately provide cancer researchers with specimens that they can use to develop comprehensive catalogs of genomic information on at least 50 types of human cancer. the study will create a resource available to the worldwide research community that could be used to identify and accelerate the development of new diagnostic and prognostic markers, new targets for pharmaceutical interventions, and new cancer prevention and treatment strategies. this study will be a competitive enrollment study conducted at multiple institutions.

this study will enroll subjects diagnosed with various cancers and who are scheduled to undergo surgical treatment. prior to scheduled surgery, subjects will be asked to donate a 10-20 ml blood sample. after surgery, surplus tissues (including tumor and adjacent normal tissues) not required for diagnosis will be collected. subject clinical information will be collected, including basic demographic information, medical history, family history, current cancer history and treatment. after surgery, a final pathology report will be obtained for each subject's surgical specimen. in some instances and based on the cancer indications required, longitudinal data may also be collected at a frequency of every 6 months to once per year. longitudinal data will include information on study subject survival and disease recurrence.

Eligibility criteria:
inclusion criteria: * any adult age * any sex * able to provide consent for surplus tissue and/or blood donation * diagnosed with one of the cancer indications listed below: * scheduled to undergo surgical resection of tumor (exception for hematological cancers) * have not yet received treatment for cancer exclusion criteria: * not diagnosed with required cancer indication * not scheduled to undergo surgical resection of the tumor * have already received cancer treatment (such as chemotherapy, radiation, surgery) for the current cancer or a previously diagnosed cancer * not able to donate an adequate volume of blood to meet minimum requirements cancer indications: 1. bladder cancer - urothelial carcinoma - nonpapillary 2. bladder cancer - urothelial carcinoma - papillary 3. brain cancer - astrocytoma 4. brain cancer - glioblastoma 5. brain cancer - medulloblastoma 6. breast cancer - ductal carcinoma 7. breast cancer - lobular carcinoma 8. cervical cancer - squamous cell carcinoma 9. colorectal cancer - adenocarcinoma 10. esophageal cancer - adenocarcinoma 11. gastric cancer 12. head and neck cancer - squamous cell carcinoma 13. hematologic cancer - acute lymphocytic leukemia (all) 14. hematologic cancer - acute myeloid leukemia (aml) 15. hematologic cancer - chronic lymphocytic leukemia (cll) 16. hematologic cancer - diffuse large b-cell lymphoma 17. hematologic cancer - multiple myeloma (mm) 18. hematologic cancer - non-hodgkins lymphoma (nhl) 19. kidney cancer - papillary carcinoma 20. kidney cancer - renal cell carcinoma 21. liver cancer - hepatocellular carcinoma 22. lung cancer - adenocarcinoma 23. lung cancer - squamous cell cancer 24. melanoma 25. pancreatic cancer - ductal adenocarcinoma 26. prostate cancer - adenocarcinoma 27. sarcomas 28. thyroid cancer - follicular carcinoma 29. thyroid cancer - papillary carcinoma 30. uterine cancer - endometrial carcinoma