Kornimate/medical-research-clean huggingface dataset:
telephone cognitive-behavioral therapy (cbt) for subthreshold depression and presenteeism in workplace

Conditions: Depression

Summary: the purpose of the study is to examine the effectiveness of telephone cognitive-behavioral therapy for subthreshold depression and presenteeism in workplace, in comparison with treatment-as-usual (tau) (which is minimal contact through employers assistance program (eap)).


Eligibility criteria:
inclusion criteria: * age 20-57 at study entry \[because the retirement age is usually 60, we have to recruit the patients well before 60 in order to allow time for follow-up\] * men and women * currently employed full-time (either regular or temporary) by the business company * expected to be employed full-time for 2 years after screening * k6 scores greater than or equal to 9 (or 10) at screening * bdi2 scores greater than or equal to 10 at 2nd screening (composite international diagnostic interview (cidi) interview) exclusion criteria: * part-time employees * sick leave for 6 or more days for a physical or mental condition in the past month * expected to be on pregnancy leave, maternity leave or nursing leave within 2 years after screening * current treatment for a mental health problem from a mental health professional * major depressive episode in the past month, as ascertained by cidi \[we do not exclude dysthymia or major depression in partial remission\] * lifetime history of bipolar disorder, as ascertained by cidi * any substance dependence in the past 12 months, as ascertained by cidi. \[we do not exclude substance abuse.\] * any other current mental disorder if it constitutes the predominant aspect of the clinical presentation and requires treatment not offered in the project * those who have already received the telephone cbt in the pilot runs

Keywords: depressive disorder behavior therapy workplace subthreshold depression
effect of anesthetic drugs on neurocognitive function in children with retinoblastoma requiring multiple anesthetic exposure - preliminary study

Conditions: Retinoblastoma

Summary: this study evaluate the effect of dexmedetomidine on intelligence test in pediatric patients with multiple anesthesia exposure. children who are diagnosed with retinoblastoma and receive first exam under general anesthesia before age of 2 are included. intelligence test will performed when patients' age are 4.


Eligibility criteria:
inclusion criteria: * patients who are first diagnosed as retinoblastoma and scheduled for eua and treatment under general anesthesia before age of 2 exclusion criteria: -
a study on early removal of urinary catheter after gastric cancer surgery applying eras protocols

Conditions: Urinary Catheter Removal After Surgery

Summary: this study compared the immediate removal of urinary catheter and early removal of urinary catheter after radical gastrectomy to explore the feasibility of immediate removal of urinary catheter after radical gastrectomy, especially in the incidence of urinary retention, whether immediate removal is not inferior to early removal.


Eligibility criteria:
inclusion criteria: * underwent elective radical gastrectomy * applied eras protocols during perioperative period * aged 18～80 years old exclusion criteria: * benign prostatic hyperplasia * urinary system stones, tumors, strictures, deformities or surgeries * pelvic surgery history * abnormal preoperative urine routine * medication intake that affects urination function
measurements of resting energy expenditure in patients with or at risk of developing graft versus host disease

Conditions: Graft-Versus-Host Disease

Summary: this study aims to show that the medgem indirect calorimetry measurement device will be feasible to use in children with gvhd. also, it aims to show that children with chronic gvhd will have elevated ree that is not adequately predicted by standard equations.

chronic graft versus host disease (gvhd) is an important cause of morbidity and mortality in patients undergoing allogeneic bone marrow and hematopoietic progenitor cell transplantation. in adults, it has been shown that patients with acute or chronic gvhd have an increase in their resting energy expenditure (ree), likely as a result of chronic systemic inflammation. these studies have not yet been performed in children. this study's objective is to determine the ree of pediatric patients with acute and chronic gvhd after hematopoietic stem cell transplantation (hsct).

Eligibility criteria:
inclusion criteria: * subjects must be 7-30 years of age * signed informed consent * one of the following three criteria must be met: * presence of grade ii or greater acute gvhd as defined by keystone criteria * presence of clinically extensive chronic gvhd as defined by the revised seattle criteria * any subject identified prior to allogeneic transplant, or following allogeneic transplant, who is at risk for acute or chronic gvhd exclusion criteria: * inability to meet the requirements of the study procedures * any subject who is receiving supplemental oxygen * withdrawal of consent

Keywords: graft-versus-host disease transplantation, allogeneic transplantation, hematopoietic stem cell calorimetry, respiration
myomectomy during cesarean section

Conditions: Myomectomy

Summary: cesarean myomectomy, safety and effect on uterine cavity.

this study aims to compare between women who underwent cesarean myomectomy and those who underwent cesarean section only regarding the procedure safety and whether uterine cavity was affected later on.

Eligibility criteria:
inclusion criteria: * pregnant * full term * had uterine myoma exclusion criteria: * history of coagulation disorder * antepartum hemorrhage * previous myomectomy * where additional operative procedures were performed
individualized physiotherapy and activity coaching for multiple sclerosis

Conditions: Multiple Sclerosis

Summary: multiple sclerosis (ms) is a chronic neurological disease that places a high burden on patients, families and society. physical activity in ms is associated with improved fitness, symptoms, and function, fewer relapses, and fewer brain lesions on mri. saskatchewan has one of the highest rates of ms worldwide, and a recent survey estimated approximately 80% of persons living with ms are not sufficiently active for health benefits. individuals living with ms recognize the importance of physical activity, but often indicate a lack support, including limited access to professionals knowledgeable about both ms and physical activity. there is a need to identify effective interventions for improving activity levels safely and appropriately. behaviour change strategies target specific behaviours involved in increasing and maintaining physical activity. the primary objective of this project is to determine if individualized behaviour change strategies delivered by neurophysiotherapists increases physical activity in ms. participants will be randomly assigned into two groups. the intervention group will receive individualized behaviour change strategies delivered through the support of neurophysiotherapists for 12 months. the wait-list control group will receive usual care for 12 months, and then be offered the intervention for a 6-month period at the end of the study period. the long-term goal of this research is to help decrease the burden of ms by identifying new opportunities for increasing physical activity.


Eligibility criteria:
inclusion criteria: * clinically definite ms (diagnosed by a neurologist) * patient determined disease steps (pdds) less than or equal to 6 (i.e. not wheel-chair bound) * glteq\<24 (not active enough for health benefits) exclusion criteria: * medical instability (par-q moderate-high risk of exercise-related harm) * persons unable to provide consent * persons under the age of 18 years old

Keywords: randomized controlled trial multiple sclerosis physiotherapy behaviour change physical activity exercise disability progression walking function
an anti-viral combination study with japanese hepatitis c infection (hcv) subject

Conditions: Hepatitis C Infection

Summary: to assess the efficacy and safety profile of co-administration of bms-790052 and bms-650032 for 24 weeks treatment.


Eligibility criteria:
inclusion criteria: * subjects chronically infected with hcv genotype 1 * hcv rna viral load of ≥ 10\*5\* iu/ml (100,000 iu/ml) at screening exclusion criteria: * subjects with evidence of liver cirrhosis * evidence of hcc * co-infection with hepatitis b virus, hiv
disease course in oncological patients during inpatient rehabilitation and after three months follow-up

Conditions: Oncologic Disorders

Summary: constant improvements in the areas of diagnostics and treatment lead to an increase of patients surviving an oncological diagnosis ("cancer survivors") thus increasing the cost factor on both society and health care systems. meta-analysis have shown the effectiveness of multidimensional rehabilitation programs concerning cost-effectiveness and for improving different health parameters. however when submitted to oncological rehabilitation in switzerland there is no clear definition when to use which specific assessment during the different stages of oncological rehabilitation. this cohort study aims to evaluate and systematically follow-up patients that are assigned for oncological inpatient rehabilitation at the rehabilitation center walenstadtberg. the main purposes are i) to evaluate disease onset of oncological patients during rehabilitation and to identify relationships between mobility and cancer-related fatigue at discharge; ii) to identify predictive factors for everyday functioning and social participation after three months discharge.


Eligibility criteria:
inclusion criteria: * diagnosed with "cancer"; * literacy and understanding german language; * signed informed consent; exclusion criteria: * women who are pregnant or breastfeeding / have the intention to become pregnant during the course of the study; * other clinically significant concomitant disease states (e.g. renal failure, hepatic dysfunction, cardiovascular disease, etc); * known or suspected non-compliance, drug or alcohol abuse; * inability to follow the procedures of the study: e.g. due to language problems, psychological disorders, dementia of the participant, etc; * enrolment of the investigator, his/her family members, employees and other dependent persons; * cognitive impairment: mini-mental state examination (mmse) \< 21; * major depression or hospital anxiety and depression scale (hads) \>11 at baseline.

Keywords: oncologic rehabilitation cancer-related fatigue patient-reported outcome measurement information system (promis)
myocardial infarction rates overview during covid-19 pandemic in france: modif study

Conditions: Myocardial Infarction

Summary: in late december 2019, an emerging disease due to a novel coronavirus (named sars-cov-2) rapidly spread in china and outside. france is currently facing the covid-19 wave with more than 131 863 confirmed cases and almost 25 201 deaths. systems of care have been reorganized in an effort to preserve hospital bed capacity, resources, and avoid exposure of patients to the hospital environment where covid-19 may be more prevalent. therefore, elective procedures of catheterization and programmed hospitalizations have been delayed. however, a significant proportion of procedures within the catheterization laboratory such as st-elevation myocardial infarction (stemi), non st elevation myocardial infarction or unstable angina are mandatory and cannot be postponed. surprisingly, invasive cardiologist noticed a drop in stemi volume without reliable data to confirm this impression. furthermore, a recent single center report in hong kong pointed out longer delays of taking care when compared to patients with stemi treated with percutaneous intervention the previous year. these data are at major concern because delay in seeking care or not seeking care could have detrimental impact on outcomes.

the aim of this study is to investigate the rates and characteristics of patients presenting with acute myocardial infarction between march 1, 2020 to may 31, 2020 and compared those data with those of this year (march 1, 2019 to may 31, 2019). the following elements will aslo been collected: * clinical presentation * mode of admission (samu (service d'aide médicale urgente in french ie emergency medical aid service) / emergency department / in hospital) * call for samu : delay, number of calls, response * thrombolysis * delays (symptom onset to first medical contact / door to balloon) * final result : timi (thrombolysis in myocardial infarction) * covid-19 status if known * underlying known ischemic cardiopathy * ecg (electrocardiogram) q waves. * complication after pci (percutaneous coronary intervention): discharged date, lvef (left ventricular ejection fraction), ventricular tachycardia data will be collected through all participating centers under the supervision of the cath lab director.

Eligibility criteria:
inclusion criteria: patients admitted on coronary angiography room for acute coronary syndrome with st segment elevation defined by the following criteria: * symptoms suggestive of myocardial ischemia (ex: persistent chest pain) and * an elevation of the st segment (measured from point j) visible on at least two contiguous leads with an elevation ≥ 2.5 millimeters in men \<40 years, or ≥ 2 millimeters in men ≥ 40 years, or ≥ 1.5 millimeters in women in v2-v3 leads and / or ≥ 1 millimeter in other leads (in the absence of branch block). exclusion criteria: - 121/5000 * contraindication to invasive management related to the general condition of the patient. * minors * pregnant women

Keywords: emergency care
5-0 prolene versus 5-0 fast absorbing gut

Conditions: Cutaneous Wound

Summary: when using suture (stitches) to close wounds, surgeons can use suture that is absorbable or non-absorbable. absorbable sutures naturally break down. non-absorbable sutures need to be removed. we wish to determine how the cosmetic result of a specific absorbable suture (fast absorbing gut) compares to that of a specific non-absorbable suture (prolene).

the purpose of this study is to determine whether the use of 5-0 prolene during repair of linear cutaneous surgery wounds improves scar cosmesis compared to wound closure with 5-0 fast absorbing gut (both soc). we will use a split wound model, where half of the wound is treated with 5-0 prolene and the other half is repaired with 5-0 fast absorbing gut. three-months post-surgery, the scar will be measured via the physician observer scar assessment scale, a validated scar instrument (research procedure). the scar width and adverse events will be recorded. there are many options when it comes to closing a linear cutaneous wound, and an important consideration is choosing between non-absorbable and absorbable sutures. the overall aesthetic superiority between the two is not well understood. studies to date have typically compared prolene (non-absorbable) and vicryl (absorbable) sutures and found no significant difference in cosmesis.1-4 one study found an increased pain score at 10 days with vicryl, but not at 6 weeks,1 while others have found no difference in pain.2-4 another study found an increased number of complications with vicryl sutures, including infections and suture granulomas.4 this supports past observations that absorbable sutures can cause more of an immune response and therefore inflammation, despite the benefit of providing more prolonged support to wound edges compared to non-absorbable sutures.1 there is a lack of data, though, comparing prolene to other absorbable sutures, such as fast absorbing gut. in the setting of blepharoplasty, a study found that a running stitch of fast absorbing gut with a simple interrupted stitch of prolene at each end of the incision yielded better cosmetic results and fewer complications than a running stitch or subcuticular stitch using prolene.5 more studies are therefore needed to compare the outcomes of linear closures using only prolene compared to only fast absorbing gut. using only absorbable sutures has the potential benefit of decreasing healthcare costs by reducing the number of appointments needed for suture removals, and, if superior in terms of cosmesis, corrective procedures.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * able to give informed consent themselves * patient scheduled for cutaneous surgical procedure on the head and neck with predicted primary closure * willing to return for follow up visit. exclusion criteria: * mentally handicapped * unable to understand written and oral english * incarceration * under 18 years of age * pregnant women * wounds with predicted closure length less than 3 cm

Keywords: suture absorbable non-absorbable split wound cutaneous wound
activities-based locomotor training program versus traditional physical therapy in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: the purpose of this study is to investigate the impact of an intensive activities-based locomotor training program as compared to traditional physical therapy on activity, participation, and central and peripheral neurophysiological adaptation in children with cerebral palsy.

observational research will be performed to assess the change in outcome measure scores over time among participants after the ab-lt intervention. outcome measures will be obtained 4 times, occurring every 3 weeks over a period of 9 weeks: pre-intervention, post-intervention, pre-traditional therapy, and post-traditional therapy. a washout period of 3 weeks will occur between the ab-lt intervention and traditional therapy.

Eligibility criteria:
inclusion criteria: * diagnosis of cp * between the ages of 2 to 12 years. * enrolled in a 3-week ab-lt program and/or participate in traditional physical therapy. exclusion criteria: * surgery or botulinum toxin injections in the previous 6 months * uncontrolled epilepsy or cardiovascular disease.

Keywords: cerebral palsy children activities-based locomotor training neuroplasticity
endocuff vision assisted vs. standard polyp resection in the colorectum

Conditions: Colon Polyp

Summary: adenomas are premalignant polyps of the colon that should be resected endoscopically. complete resection of adenomatous polyps is the major task of colonoscopy. in some cases polyp may be poorly accessible making endoscopic resection difficult. polypectomy may be conducted using the so-called piece meal technique in these cases. however, leaving polyp residual polyps in the colon bears the risk of malignant degeneration as colorectal cancer may arise form adenomatous remnants. in case of difficult polyp locations endoscopic resection may also be time consuming. on the other hand endoscopists are facing an increased time pressure due to rising numbers of procedures during the last decades. the endocuff vision device (evd) is a cap that can be mounted to the tip of a standard endoscope. the evd has small flexible branches on its outside. the branches turn out during withdrawal. by that the branches are getting in contact with colonic wall. this mechanism leads to a more stabilized position of the colonoscope in the bowel. it is hypothesized that resection circumstances may be improved by using an evd. in addition, stabilizing the scope during resection may result in a reduced time effort. until now no controlled trials exist investigating the effect of evd on the time effect during polyp resection. therefore a randomized controlled trial needed comparing standard polypectomy versus polypectomy using the evd during routine colonoscopy procedures.


Eligibility criteria:
inclusion criteria: * indication for colonoscopy * age ≥ 40 years exclusion criteria: * american society of anesthesiologists class iv or higher * pregnant women * indication for colonoscopy: inflammatory bowel disease * indication for colonoscopy: polyposis syndrome * indication for colonoscopy: emergency colonoscopy e.g. acute bleeding * contraindication for polyp resection e.g. patients on warfarin exclusion criteria: -

Keywords: colonoscopy polyp resection
picnic study - patient centered antibiotic courses in children with medical complexity

Conditions: Pneumonia

Summary: to determine if clinicians can safely reduce antibiotic exposure in children with medical complexity (cmc) who are diagnosed with pneumonia by implementing an intervention that bases total antibiotic duration on an individual's clinical stability.


Eligibility criteria:
inclusion criteria: * admitted to the complex care service at boston children's hospital with a provider diagnosis of pneumonia * started on antibiotics by the provider team * ages 2-25 years old exclusion criteria: * patients initially admitted to the intermediate care unit or icu due to increased respiratory support needs
long-term safety, tolerability and effectiveness study of ofatumumab in patients with relapsing ms

Conditions: Relapsing Multiple Sclerosis

Summary: the purpose of this study is to collect long-term safety, tolerability, effectiveness and health outcomes data in eligible subjects who have participated in a novartis ofatumumab clinical ms study. vaccination sub-study the purpose of this research sub-study is to find out the effects of ofatumumab on the development of antibody responses to selected vaccines and keyhole limpet hemocyanin (klh) neo-antigen in subjects with relapsing multiple sclerosis (rms). covid-19 sub-study: the purpose of this research sub-study is to explore the immune response following severe acute respiratory syndrome coronavirus 2 (sars-cov-2) vaccination in a subset of subjects on long-term ofatumumab 20 mg sc. note: novartis is not supplying the sars-cov-2 vaccine.


Eligibility criteria:
inclusion criteria: 1. must have completed a selected novartis ms study which dosed ofatumumab 20 mg sc every 4 weeks 2. written informed consent exclusion criteria: * emergence of any clinically significant condition/disease during the previous ofatumumab study in which study participation might result in safety risk for the subject * subjects with active systemic bacterial, viral or fingal infections, or chronic infection (e.g. aids) * subjects taking medications prohibited by the protocol * pregnant or nursing (lactating) women other protocol-defined inclusion/exclusion criteria may apply vaccination sub-study: inclusion criteria 1. informed consent 2. actively enrolled in the comb157g2399 study 3. 12 weeks of continuous treatment within the comb157g2399 study 4. prior vaccination history as per protocol-defined exclusion criteria * known hypersensitivity or history of systemic allergic, neurologic or other reactions to vaccines * allergies to egg or shellfish * any safety findings including low igg/igm requiring ofatumumab interruption within 12 weeks prior to vaccination sub-study start * any major episode of infection requiring hospitalization or treatment with intravenous antibiotics within 2 weeks of the first vaccination sub-study visit other protocol-defined inclusion/exclusion criteria may apply

Keywords: ofatumumab relapsing multiple sclerosis