Kornimate/medical-research-clean huggingface dataset:
standardization of quantitative muscle ultrasonographic parameters among egyptian population

Conditions: Muscle Disease

Summary: 1-standardization of semi quantitative muscle ultrasonographic parameters ( muscle thickness (mt) and echo intensity (ei) ) in healthy adults and to obtain a set of normal values of all accessible muscle in both upper and lower limbs. 2.standardizaition of quantitative muscle ultrasonographic parameters (gray scale level (gsl), calibrated muscle backscatter values (cmbs), optical density (od), 2d textu1) in healthy adults and to obtain a set of normal values of all accessible muscle in both upper and lower limbs.

. ultrasound is a widely used imaging technique in many different medical specialties. it is a non-invasive, safe and relatively cheap investigation method. ultrasound is a non-invasive method to quantitatively measure various muscle parameters. ultrasound imaging (us) has shown to be capable of visualizing normal and pathological skeletal muscles.(1) by measuring muscle thickness (mt) and echo intensity (ei) (=grey-value) of the muscle, structural changes caused by neuromuscular disorders can be detected. (2, 3, 4) quantitative evaluation of us images is preferable over visual evaluation, because it is more sensitive and objective and offers the possibility to perform statistical analysis.(5) a prerequisite for the diagnostic use of quantitative muscle us is the availability of normal reference values. ultrasonography can detect structural muscle changes caused by neuromuscular disease. quantitative analysis is the preferred method to determine if ultrasound findings are within normal limits, but normative data are incomplete.(6)

Eligibility criteria:
inclusion criteria: 1. healthy subjects were recruited amongst colleagues and family members of the researchers 2. age group (5-70)years 3. male and female. exclusion criteria: 1. patient refuse to participate 2. the anatomy is altered due to sever trauma,tumor,or surgery
patient satisfaction with the management of a stopped pregnancy in the first trimester

Conditions: Pregnancy Loss, Early

Summary: the clinical practice recommendations highlight the fact that the patient's choice concerning the management of her aborted pregnancy in the first trimester should be privileged, after clear and appropriate information on the available treatments, in order to improve his experience and reduce the negative psychological symptoms that can generate an alteration in the quality of life, in the aftermath of the loss of pregnancy. the present study will describe the efficacy, satisfaction and tolerance of patients benefiting from medical treatment with mifégyne® and misoone® versus those benefiting from surgical treatment by endo-uterine aspiration for the management of a pregnancy stopped during the first trimester at the toulouse university hospital


Eligibility criteria:
inclusion criteria: * any adult patient presenting to the gynecological emergency department of the paule de viguier hospital in toulouse for whom a diagnosis of an arrested pregnancy in the first trimester is made * whose cranio-caudal length of the embryo measured by ultrasound is less than 25 mm or having a clear egg * having agreed to the study (written or verbal) after clear and fair information * who understands and reads french exclusion criteria: * medical contraindication to treatment with mifégyne® or misoone® * hemodynamically unstable patient requiring urgent surgical treatment. * protected adult patient (guardianship, curatorship, safeguard of justice)
collaborative seamless care in oncology : measure and reinforce safety and adherence to oral cancer treatment

Conditions: Cancer

Summary: the purpose of this study is to implement a support interdisciplinary program(oncologists, pharmacists, physicians, nurses, leagues against cancer) of medication adherence to oral oncology treatments. the aim is to ensure continuity of care between professionals,effectiveness of treatment and patient safety.

80 patients will be included in swiss-romande hospitals and private oncologists and followed by thirty study pharmacies. each refusal and drop-out will be documented. follow-up duration is 48 weeks, with a motivational interviewing at least every three months. patient adherence will be assessed electronically by mems (medication event monitoring system).

Eligibility criteria:
inclusion criteria: * 18 years and older * treated for a cancer with oral medication (letrozol, exemestan,imatinib, sunitinib, nilotinib, everolimus, deferasirox) * french speaking exclusion criteria: - none

Keywords: medication adherence patient compliance patient acceptance of health care administration, oral cancer letrozol exemestan imatinib sunitinib nilotinib everolimus deferasirox
an extension study of ro5045337 in participants participating in previous roche-sponsored cancer studies

Conditions: Myelogenous Leukemia, Chronic, Neoplasms, Myelogenous Leukemia, Acute

Summary: this open-label, extension study is designed to provide continuing treatment with ro5045337 to participants who have completed parent studies no21279 (nct00623870), no21280 (nct00559533), np25299 (nct01164033), np28021 (nct01605526) or np28023 (nct01635296). participants are eligible to participate in this study if they have completed required phase 1 study assessments for primary objectives of respective parent protocol and are having evidence of clinical benefit (as defined by the parent protocol). participants will continue the most similar dose and formulation available (which does not exceed the maximum tolerated dose \[mtd\] or the maximum safely administered dose for that formulation during phase 1) and the same schedule of ro5045337 treatment that they were receiving at the time of transitioning from the parent clinical study protocol.


Eligibility criteria:
inclusion criteria: * participants must meet the inclusion criteria outlined in the respective parent protocols: no21279 (nct00623870), no21280 (nct00559533), np25299 (nct01164033), np28021 (nct01605526) or np28023 (nct01635296) * participants must have completed one of the following clinical study protocols and have been determined to have clinical benefit on treatment at the conclusion of required study analyses as defined in the respective parent protocols: no21279 (nct00623870), no21280 (nct00559533), np25299 (nct01164033), np28021 (nct01605526) or np28023 (nct01635296) exclusion criteria: * participants must meet the exclusion criteria outlined in the respective parent protocols: no21279 (nct00623870), no21280 (nct00559533), np25299 (nct01164033), np28021 (nct01605526) or np28023 (nct01635296) * participants who developed disease progression/ requiring other anti-tumor therapy while in the parent protocol * participants who have stopped study drug dosing for greater than 56 days * participants continuing to require dose modifications * participants with worsening adverse events * participants with unrelated adverse events, medical illnesses, or changes in performance status that, per investigator discretion, put them at high risk for continuing participation in the clinical study
percutaneous peristyloid glossopharyngeal block after tonsillectomy

Conditions: Postoperative Pain

Summary: adenotonsillectomy surgery in paediatrics is commonly managed as an ambulatory surgery. this may be attributed to the use of the electro-dissection surgical technique that decreases the incidence of immediate postoperative haemorrhage. however, the use of the electro-cautery technique increases postoperative inflammation. this study aimed to compare the glossopharyngeal nerve block using the blind technique with the use of the ultrasound guidance primary: flacc score in the two groups 0,2,4,6 h after surgery at rest and with swallowing secondary: need to analgesics, the difficulty of the technique, time consumption, recovery time, surgeon satisfaction, parents satisfaction, staff nurse satisfaction, anaesthetist self-confidence

introduction adenotonsillectomy surgery in paediatrics is commonly managed as an ambulatory surgery. this may be attributed to the use of the electro-dissection surgical technique that decreases the incidence of immediate postoperative haemorrhage. however, the use of the electro-cautery technique increases postoperative inflammation. sensory fibres of the glossopharyngeal nerve supply the tonsillar and peri-tonsillar areas. thus, a bilateral glossopharyngeal nerve block may alleviate post-tonsillectomy pain and improve postoperative analgesia. this is a prospective randomized controlled clinical study, to compare two different technique used to block the glossopharyngeal nerve. aim of work to improve post tonsillectomy pain control in children anaesthesia, postoperative analgesia paediatrics 3-7 years tonsillectomy not adenotonsillectomy postoperative control of pain objectives this study aimed to compare the glossopharyngeal nerve block using the blind technique with the use of the ultrasound guidance primary: flacc score in the two groups 0,2,4,6 h after surgery at rest and with swallowing secondary: need to analgesics, the difficulty of the technique, time consumption, recovery time, surgeon satisfaction, parents satisfaction, staff nurse satisfaction, anaesthetist self-confidence methodology 54 asa i children allocated randomly into two groups: group bl: blind percutaneous peristyloid injection group us: ultrasound-guided percutaneous peristyloid glossopharyngeal nerve block 54 children aged 3 to 7 years undergoing adenotonsillectomy without adenoidectomy were randomized to receive either local blind percutaneous peistyloid glossopharyngeal nerve block (n=27) or the use of ultrasound guidance for the same block (n=27). the pain was assessed by the flacc scale or face, legs, activity, cry, consolability scale, need for analgesics, and acceptance of diet during the postoperative period.

Eligibility criteria:
inclusion criteria: * children aged 3-7 years * scheduled for tonsillectomy exclusion criteria: * younger or elder children * associated adenoidectomy * history of allergy to local anaesthetics

Keywords: analgesia tonsillectomy
biomarkers predictive of thymic evolution and therapeutic response at 2 years in patients with a first psychotic episode

Conditions: First-episode Psychosis

Summary: psychosis is a severe, common, and disabling psychological disorder. an epidemiological study conducted in england reported an incidence of 34 new cases per 100,000 person-years, with a peak between 16 and 19 years of age. following a first psychotic episode, two clinical evolutions are possible: thymic psychosis (17%) and non thymic psychosis (83%). the first includes bipolar disorders with a psychotic component and major depressive disorders with a psychotic component; the second, other psychotic disorders, mainly schizophrenia. one of the major difficulties encountered is the frequent impossibility of specifying the type of psychosis at the beginning of the psychotic episode. however, these disorders require different therapies, particularly medication. this leads to a delay in diagnosis with a high risk of relapse. the semiological study of these diseases being carried out within the framework of interviews, it seems interesting to be able to record these and to obtain a quantitative and objective measurement through the study of language. the use of machine learning has made it possible to distinguish patients with schizophrenia from those with bipolar disorder by graphical analysis of language in a more efficient way than with clinical scales.moreover, it is possible to identify linguistic markers: thus, an alteration of syntactic structures and prosody would be more present in non-thymic than in thymic psychoses. paraclinical markers are also emerging. in particular, the link between inflammation and mental disorders.for example, an increase in il-8 has been found only in thymic psychoses. in this context, it seems essential to be able to distinguish these disorders as early as possible through the combined use of clinical and paraclinical markers, and to be able to better understand their pathophysiology.


Eligibility criteria:
inclusion criteria: * patient with a first episode of psychosis, * aged between 15 and 30 years, * able to consent and having signed a consent form (parental consent for minors). exclusion criteria: * introduction or increase of antipsychotic and/or antidepressant and/or thymoregulatory treatment in the last month, * mother tongue other than french, * psychotic episode due to an organic disorder, * psychotic episode induced by the use or withdrawal of toxic substances with severe dependence , * intellectual deficit, * chronic inflammatory disease, * immunomodulatory treatment, * contraindication to mri, * pregnant or breastfeeding woman, * patient under court protection, guardianship, curatorship or deprived of liberty.

Keywords: bipolar disorder schizophrenia
comparison of bupivacaine versus bupivacaine-dexamethasone infiltration for postoperative analgesia in skin graft donor sites

Conditions: Postoperative Pain Atskin Graft Site

Summary: background: skin grafting; both partial and complete thickness is frequently used in reconstruction of traumatic soft tissue defects. it is of great value not only for functional and aesthetic purposes in the field of plastic surgery, but also for other surgical specialties. of all the problems in the early postoperative period, pain is considered the most important, ameliorating it can lead to significant reduction in postoperative morbidity and faster recovery of the skin donor site. objective: to evaluate use of dexamethasone as adjuvant for bupivacaine in subcutaneous local anesthesia infiltration for skin graft donor sites, on quality of pain relief and total dose of analgesic requirements in the early hours postoperatively. methods: 97 patients were randomly allocated to receive local bupivacaine infiltration (group lb), or dexamethasone plus bupivacaine (group lb + d) in skin donor site after skin harvesting. in addition to basic demographic data; patients were compared for numerical rating scale (nrs), total dose of morphine or morphine equivalents, time to 1st breakthrough pain, and duration of surgery. keywords: donor site. skin graft. breakthrough pain. rescue analgesia. bupivacaine

the patients included in the study were randomly allocated to 1 of 2 parallel groups: 1) bupivacaine plus dexamethasone (lb+d) group (n = 50): received 20 ml bupivacaine 0.5% + 18 ml normal saline + 8 mg dexamethasone 2 ml, 2) bupivacaine only (lb) group (n = 50): received 20 ml bupivacaine 0.5% + 20 ml normal saline. a random allocation sequence was generated electronically using online randomization service from https://www.random.org. the project medicine was prepared by 2 independent assistants not involved in other parts of the study. all persons involved were blinded to the randomized allocation.

Eligibility criteria:
inclusion criteria: * anesthesiologists physical status classification i-ii and scheduled for split thickness skin grafting to cover full thickness skin burn or degloving injury after trauma. exclusion criteria: * were inability to cooperate. * immunosuppressive therapy. * body mass index \> 35. * diabetes. * lower-limb neuropathy. * daily intake of glucocorticoids or opioids. * patients who need area of coverage more than 10 cm2. * allergy to any drug used in the study. * alcohol or drug abuse. * american society of anesthesiologists physical status classification iii or more.

Keywords: bupivacaine,dexamethasone,analgesia,skin graft ,donor
benefits of diving training on recovery for veterans suffering of chronic ptsd: an exploratory study

Conditions: Stress Disorder, Combat

Summary: patients suffering from chronic posttraumatic stress disorder (ptsd) have difficulties in executive cognition that hinder their quality of life and make it difficult to recovery and to reintegrate them socially and professionally. these difficulties are particularly important for soldiers suffering from chronic ptsd. the literature suggests that diving may be a complementary approach to improving cognition, in addition to its benefits on the quality of life of patients with chronic ptsd. it appears to be an intervention of interest to improve the successful recovery for veterans with ptsd compared to a multi-sport practice.

a french military rehabilitation program proposes the broadening of the relationships between recovery and reintegration by incorporating approaches in the field of positive psychology for soldiers with chronic ptsd. this program was organized for a group of 10 veterans for 10 days. each morning, from 9 am to 12 pm, participants had sporting activities: mountain walking, mountain biking, climbing, canyoning and collective orienteering running. from 3 pm, they had individual and collective practical workshops based on ptsd psychoeducation, human resources competences and coaching, including a curriculum vitae workshop. the investigators aims to compare this program included multisport practice with the same praogram included diving instead of multi-sport to evaluate the impact to recovery at one year

Eligibility criteria:
inclusion criteria: * veterans * having a chronic ptsd evaluated by a psychiatrist all soldiers included in this study were on sick leave for at least 6 months due to chronic ptsd and were waiting for a military invalidity committee pension. they were all engaged in the first step of the omega project and had a nine-day hrt training session planned exclusion criteria: * the psychiatrist did not consider the clinical state appropriate enough to take part in the omega project
rem (risk of endometrial malignancy)

Conditions: Endometrial Disease

Summary: the purpose of this study was to obtain a predictive model to asses the risk of endometrial malignancy (rem) in women with ultrasound endometrial abnormalities.

objective: it is often difficult to distinguish a benign endometrial disease from a malignancy and tools to help physician are needed, in order to triage patients into high and low risk of endometrial cancer (ec). the purpose of this study was to obtain a predictive model to asses the risk of endometrial malignancy (rem) in women with ultrasound endometrial abnormalities.women, between 45 and 80 years, diagnosed with ultrasound endometrial abnormalities and scheduled to have surgery were enrolled on a prospective study at department of gynaecologic oncology of campus bio-medico of rome. preoperative clinical, ultrasound and laboratory features were taken into account. logistic regression algorithm was utilized to categorize patients into low and high risk groups for ec.

Eligibility criteria:
inclusion criteria: 1. aged between 45 and 80 years; 2. eastern cooperative oncology group performance status 0-2 according to world health organization (who) criteria; 3. informed consent obtained from the patients. exclusion criteria: 1. abnormal cardiac, haematological, renal, respiratory and/or hepatic functions; 2. presence of a previous malignancy; 3. presence of concomitant adnexal masses.

Keywords: endometrial cancer score nomogram ultrasound he4
clinical efficacy and mechanism of high definition tdcs based on dmpfc in the intervention of chronic insomnia

Conditions: Chronic Insomnia; Transcranial Direct Current Stimulation

Summary: to investigate the intervention effect of transcranial direct current stimulation (tdcs) on subjective and objective insomnia symptoms and daytime function of chronic insomnia patients.

fifty patients with chronic insomnia disorder diagnosed by the diagnostic criteria and treatment guidelines for adult insomnia (2017) were recruited from the first affiliated hospital of anhui medical university. after meeting the inclusion criteria and obtaining informed consent, each participant will complete the subjective measures consisting of sleep questionnaires, polysomnography (psg) and tdcs treatment conducted by trained researchers at the neurology department of anhui medical university. all the participants were randomized (1:1) to receive "active" or "sham" treatment protocol. the anode electrode was placed on the dmpfc (fz) surrounded by four cathodes with a 1cm diameter (fpz, f3, cz, and f4). each participant received 30 min of tdcs stimulation once daily for 10 consecutive days. the stimulation direct current magnitude was set at 2 ma in the active group. in the sham intervention phase, the sensation was simulated by applying a 30s rising current until 2 ma was reached, with a 30s immediate decline at the beginning and end of each phase. at the beginning and after a 10-day intervention, subjective measures consisting of sleep questionnaires, including the pittsburgh sleep quality index (psqi) and insomnia severity index (isi), were assessed. the flinders fatigue scale (ffs) and the epworth sleepiness scale (ess) were used to assess daytime sleepiness. additionally, the hama and hamd were used synchronously for emotional assessment. afterwards, they were unblinded by the study coordinator.

Eligibility criteria:
inclusion criteria: 1. age between 15 and 65 years, 2. diagnosed with chronic insomnia based on the diagnostic criteria and treatment guidelines for adult insomnia (2017), 3. no previous application of any insomnia pharmacological therapy for at least one week before baseline visit. exclusion criteria: 1. diagnosis of other sleep disorders, such as sleep apnoea-hypopnoea syndrome, rem behaviour disorder, and restless legs syndrome, 2. history of head trauma or presence of serious organic diseases, 3. presence of comorbid anxiety or depression, as assessed by a hamilton anxiety scale \[hama\] score of 17 or hamilton depression scale \[hamd\] score of 14.

Keywords: chronic insomnia hd-tdcs