Kornimate/medical-research-clean huggingface dataset:
understanding the genetic and hereditary basis of atherosclerosis

Conditions: Atherosclerosis; Cardiovascular Diseases

Summary: atherosclerosis is a condition that occurs when fatty deposits build up along the inner walls of arteries. new strategies are needed to prevent and treat atherosclerosis. the purpose of this study is to analyze the dna of participants in two ongoing studies to identify genetic variations responsible for the development of atherosclerosis.

atherosclerosis is a condition in which deposits of fat, cholesterol, and other substances build up along the inner walls of arteries; these deposits are known as plaque. as plaque builds up, it increases the risk of blood clots, heart attack, and stroke. research has shown that the risk of developing atherosclerosis can be influenced by heredity. however, researchers have been unable to identify the specific genes associated with this risk. single nucleotide polymorphisms (snps) are small genetic variations that can occur within an individual's dna. in this study, researchers will analyze the dna of many individuals for differences in snp patterns. the goal of the study is to determine which snp patterns are associated with the development of atherosclerosis. the data from this study may lead to new strategies for early identification of high risk individuals who may benefit from aggressive treatment to prevent the development of atherosclerosis. this study will not recruit any new participants. dna will be collected and analyzed from participants in two existing studies-the pathobiological determinants of atherosclerosis in youth (pday) study and the multi-ethnic study of atherosclerosis (mesa). dna from the pday participants will be obtained from liver samples gathered during an autopsy following the participants' deaths; dna from the mesa participants will be obtained from blood collected during routine study visits. there will be no additional study visits for participants, and all dna samples and study information will be kept confidential. genetic testing will be performed to determine the association between snps and subclinical atherosclerosis, which is a form of the condition prior to the onset of symptoms. the study will evaluate specific variations in snps and subclinical disease among different ethnic groups, which may help to explain why certain ethnic groups have higher rates of atherosclerosis. the study will also examine the association between snps and other indicators of subclinical and clinical atherosclerosis, including the thickness of arteries, heart calcium levels, and blood pressure levels.

Eligibility criteria:
inclusion criteria: * participant in pday or mesa

Keywords: polymorphism, genetic coronary artery disease coronary arteriosclerosis polymorphism, single nucleotide snps
chicago social drinking project

Conditions: Alcoholism

Summary: this study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by: 1. examining subjective and objective response differences to alcohol and other common substances in a sample of adults with varying consumption patterns. 2. determining whether response to alcohol and other substances is predictive of future consumption patterns through longitudinal follow-up interviews. 3. examining the relationship between responses to alcohol and other substances at baseline and re-examination testing to evaluate if consumption patterns moderate this relationship.


Eligibility criteria:
inclusion criteria: * age 21-65 * weigh between 110-210 lbs * drink alcohol at least once weekly with weekly "binge" drinking episodes * available to complete in-person screening and 2, 4 hour experimental sessions at the university of chicago * available by phone, mail, or internet for follow-up interviews for at least 2 years following sessions exclusion criteria: * current or past major medical or psychiatric disorders including alcohol and substance dependence
rapid and highly sensitive detection of fluorescently-labeled troponin in patients admitted with chest pain

Conditions: Chest Pain

Summary: patients with chest pain may have postponed or missed diagnosis of acute coronary events due to relatively late detection of troponin elevation. the study will investigate a new diagnostic method for early detection of even minimal troponin elevation in patients admitted with chest pain.

patients with chest pain may have postponed or missed diagnosis of acute coronary events due to relatively late detection of troponin elevation. the study will investigate a new diagnostic method for early detection of even minimal troponin elevation in patients admitted with chest pain. a new diagnostic method will be applicated in the recent studies.

Eligibility criteria:
inclusion criteria: 1. patients 18 years old or older 2. admitted to rambam health campus for the investigation of chest pain exclusion criteria: 1. no exclusion criteria will be applied
impact evaluation of a family-based intervention with burmese migrant and displaced children and families in tak province, thailand

Conditions: Parenting Practices; Family Functioning; Child Psychosocial Well-being; Alcohol Use

Summary: the study will evaluate the impact of a family-based intervention on the well-being of burmese migrant and displaced children and families living in tak province, thailand. the methodology used in the impact evaluation study is a randomized waitlist controlled trial. the study hypothesizes that participation in a family-based intervention will lead to improved parenting practices and child and family outcomes, as follows. primary hypotheses: 1. parents/caregivers participating in the family-based intervention will report increased knowledge and use of positive parenting skills compared to control; 2. parents/caregivers participating in the family-based intervention will report less use of physical punishment and other harsh forms of discipline compared to control; 3. parents/caregivers and children participating in the family-based intervention will report higher levels of family functioning and cohesion compared to control. secondary hypotheses: 1. parents/caregivers and children participating in the family-based intervention will report lower levels of externalizing and internalizing child behaviors compared to control; 2. parents/caregivers and children participating in the family-based intervention will report higher levels of child resilience and psychosocial well-being compared to control; 3. parents/caregivers participating in the family-based intervention will report lower levels of alcohol use compared to control.


Eligibility criteria:
inclusion criteria: * of burmese origin * currently living in one of 20 target communities in tak province, thailand * primary caregiver to at least one child aged 8 to 12 years * child aged 8 to 12 years * participating in the family intervention exclusion criteria: * children living in orphanages, boarding houses, factories or other institutions * persons with severe cognitive or physical disability who are impaired and unable to understand and give informed consent

Keywords: parenting discipline family interventions thailand migration
clinical survey of different abutment topologies

Conditions: Conductive Hearing Loss; Unilateral Partial Deafness; Mixed Hearing Loss

Summary: this study is designed to compare two different surfaces of bone anchored hearing aid abutments in terms of bacterial colonization, inflammatory response and skin reactions.


Eligibility criteria:
inclusion criteria: * any adult (18 years of age or older) patient eligible for a bone anchored hearing system exclusion criteria: * inability or unwillingness to participate in follow-up * skin thickness of \> 10 mm * diseases known to compromise bone quality * irradiated in the implant area
safety and efficacy of hs-ctnt protocols

Conditions: Chest Pain; Diagnosis

Summary: chest pain is a common presenting complaint among patients in the emergency department (ed). a large portion of patients with chest pain undergo lengthy assessment in the ed or are admitted to rule out acute oronary syndrome (acs), often with stress testing, creating a substantial health care burden. the new high-sensitivity cardiac troponin assays allow use of shorter time intervals for repeated blood samples and may improve care for chest pain patients. the aim of this cohort is to evaluate high-sentivity troponin based protocols for ruling out and ruling in acs in the ed.

this is a prospective observational study conducted at skåne university hospital (lund, sweden). patients presenting with non-traumatic chest pain and for whom hs-ctnt testing was ordered at presentation will be enrolled between february 2013 to april 2014 after providing written informed consent. patients with stemi during index visit and those with severe communication barriers will not be enrolled. enrolled patients will have a second blood sample for hs-ctnt analyzed 1 h after the first sample. patients with hemolysis with a hemoglobin concentration \>0.1 g/dl, h-index \>=100 in either the 0- or 1-h sample will be excluded. clinical data and 1-h high sensitivity troponin t samples will be collected by research assistants. further diagnostic testing and treatment will be performed, as in routine care, at the discretion of the responsible physician.

Eligibility criteria:
inclusion criteria: * \>=18 years of age * presented to the ed with non-traumatic chest pain/discomfort * hs-ctnt testing was ordered at presentation exclusion criteria: * stemi at presentation * severe communication barriers * hemolysis with a hemoglobin concentration\>0.1 g/dl, h-index\>=100
comparing radical surgery and radical radiotherapy as first definitive treatment for primary mcc

Conditions: Merkel Cell Carcinoma

Summary: a randomised phase iii multi-centre trial comparing radical surgery and radical radiotherapy as first definitive treatment for primary mcc

a randomised phase iii multi-centre trial comparing radical surgery and radical radiotherapy as first definitive treatment for primary mcc with an observational study for patients ineligible for the randomised trial.

Eligibility criteria:
inclusion criteria: general inclusion criteria for all patients: 1. patients newly diagnosed with histologically-proven mcc (either primary and/or regional nodal disease) 2. completion of clinical and radiological staging investigations, including ct imaging (or other modality) of regional nodal basin(s) and major viscera (and slnb if clinically appropriate) to identify regional and distant metastases 3. no confirmed distant metastases beyond the regional nodal basin (i.e. not stage iv disease) 4. suitable for radical treatment to achieve disease control 5. able to give valid informed consent 6. consent for collection of data and tissue samples and follow up 7. life expectancy six months or greater in relation to general fitness and co-morbidities additional inclusion criteria for rational compare: 1. patients newly diagnosed with histologically-proven primary mcc 2. in the opinion of the ssmdt, the primary mcc can be encompassed both within a wide surgical margin and within a radiotherapy field, and the ssmdt is in equipoise regarding wle or radiotherapy as first treatment 3. a minimum margin of 1 cm surrounding the mcc achievable by either radiotherapy or surgery 4. consent for randomisation into rational compare exclusion criteria: 1. the primary mcc has already been treated radically with wle (surgical margins \>10 mm) or radiotherapy 2. intended use of regional or systemic chemotherapy for mcc (including molecularly targeted agents and immunotherapy)
functional capacity in survivors of covid-19 related ards

Conditions: Covid19; Functional Capacity; Post-intensive Care Syndrome

Summary: acute respiratory distress syndrome survivors frequently develop impaired physical function, muscle weakness and quality of life. the aim of this retrospective study is to determine the functional capacity, global muscle weakness and quality of life of covid-19 survivors after 4 weeks following hospital discharge and the relationship between different tools. covid-19 related acute respiratory distress syndrome survivors were assessed 4 weeks following discharge from the hospital, 15 patients who attended the evaluation will be included the study. all subjects underwent standardized physical clinical evaluation, medical research council-sumscore, hand-grip strength, 6-minute walk test, chair-stand test, timed up and go test and short form-36, 4 weeks after hospital discharge.

covid-19 could cause acute respiratory distress syndrome in a minority of patients. after recovery from acute critical illness and discharged from hospital, secondary disabilities related to post intensive care syndrome could take over the role. there is limited data and information about the functional capacity of these patients after hospital discharge.follow-up these patients after discharge might help assessing the symptoms of post intensive care syndrome, functional capacity and need of physical therapy, therefore give care for the impairments. the aim of this retrospective cross-sectional study is to demonstrate the functional capacity, global muscle weakness and quality of life of covid-19 survivors after 4 weeks following hospital discharge and the relationship between different tools. appointment was given all of the ards survivors related to covid-19 who treated in icu after 4 weeks following discharge from hospital in order to assess the need of rehabilitation. 15 patients who attended the evaluation will be included the study.

Eligibility criteria:
inclusion criteria: * to be older that 18 years * acute respiratory distress syndrome survivors related to covid-19 who treated in intensive care unit and attend appointment after 4 weeks following discharge from hospital exclusion criteria: * history of diseases that could affect functional capacity, muscle strength and quality of life, such as cancer, spinal cord disease, neuromuscular diseases * do not want to attend the study

Keywords: covid-19 acute respiratory distress syndrome 6-minute walk test handgrip strength mrc sumscore
gonadotropin-releasing hormone agonist prior to myomectomy

Conditions: Fibroids

Summary: fibroids are common in the west indian population (30-40% of reproductive women).fibroids are benign growth in the womb or uterus and in order to preserve the fertility of women they, require an operation called myomectomy or shelling out of the fibroid. this procedure can be associated with large blood loss. in current practice some obstetricians use a gonadotropin releasing hormone agonist prior to the operation to reduce blood loss. gonadotropin releasing hormone agonist is used in current gynaecological practice to treat women with heavy periods. in this study the investigators randomised women to either 2 or 3 doses of the gonadotropin agonist prior to their operation and no treatment. the intraoperative blood loss was measured. the study hypothesis: to determine whether administration of gonadotropin releasing hormone agonist prior to myomectomy reduces intraoperative blood loss.

variables noted preoperatively: * age * parity * ethnicity * ultrasound findings variables noted intra-operatively: * size of largest fibroid * estimated blood loss

Eligibility criteria:
inclusion criteria: * women between the age of 20 and 45 * symptomatic fibroids * presence of regular menstrual cycles * ultrasound confirmation of fibroids * normal cervical smear exclusion criteria: * pregnancy * the length of hospital stay was calculated in number of days from the date of the to the date of discharge * presence of endometriosis previous myomectomy ovarian, uterine or cervical malignancy female factor for subfertility

Keywords: myomectomy gnrh blood loss
a study to evaluate the efficacy and safety of radion™-pdt in patients with oral precancerous lesion

Conditions: Erythroleukoplakia of Mouth; Verrucous Hyperplasia of Oral Mucosa

Summary: a prospective, single-arm, open-label, phase ii study to evaluate the efficacy and safety of photodynamic therapy using radion™-pdt in patients with oral precancerous lesion (oral verrucous hyperplasia or oral erythroleukoplakia).

this is a single-center, single-arm, open-label study to evaluate the efficacy and safety of topical radion™-pdt for treatment of patients with oral verrucous hyperplasia (ovh) or oral erythroleukoplakia (oel). total duration of the study will be up to 40 weeks (from screening throughout study until completion) as follows: * screening (within 2 weeks before dosing) * treatment period (up to 14 weeks) * safety follow-up period (within 2 weeks after final treatment) * follow-up period (final treatment plus 4 weeks, 8 weeks, 16 weeks and 24 weeks respectively) all enrolled patients will receive up to 8 treatments (once every two weeks) during a maximum of 14-week study treatment period. the treated lesion will be clinically evaluated and documented (clinical photograph) at each treatment visit.

Eligibility criteria:
inclusion criteria: 1. patients aged ≥20 years old; 2. patient with oral verrucous hyperplasia (ovh) or oral erythroleukoplakia (oel) lesions with histological evidence of oral precancerous lesions. besides, patients should have at least one lesion whose size should not exceed 4 cm in the greatest diameter and the distance between two lesions should not less than 1 cm. 3. patient who is willing and able to comply with study procedures and sign informed consent exclusion criteria: 1. patients with history of hypersensitivity to any photosensitizer (including 5-aminolevulinic acid hcl or porphyrins), acute or chronic types of porphyria; 2. record of previous unsuccessful treatment with photodynamic therapy; 3. patients who have been diagnosed as having oral cancer or carcinoma in situ; 4. patients who have a history or evidence of a medical condition that would expose them to an undue risk of a significant adverse event during the course of the trial, including but not limited to hepatic, renal, respiratory, cardiovascular, endocrine, immune, neurological, hematological, gastrointestinal or psychiatric disease as determined by the clinical judgment of the investigator; 5. patients with impaired hepatic function (defined as ast and/or alt \> 2× the upper limit of normal values), and/or impaired renal function (defined as serum creatinine \> 1.5 mg/dl); 6. female patient of childbearing potential who: * is lactating; or * has positive urine pregnancy test at visit -1; or * refuses to adopt reliable method of contraception during the study; 7. patient has received any other investigational agent within 28 days or 5 half-lives, whichever is longer, prior to the first photodynamic therapy; 8. patient has a history of illegal substance abuse, drug addiction or alcoholism within 24 weeks prior to the study.

Keywords: oral verrucous hyperplasia oral erythroleukoplakia
streamline occipito-cervico-thoracic system post-market clinical follow-up

Conditions: Spinal Stenosis Occipito-Atlanto-Axial; Spinal Disease; Spinal Stenosis Cervical; Spinal Stenosis Cervicothoracic Region; Spinal Instability

Summary: this is a multi-center, post-market, retrospective study design to collect safety and performance data for patients implanted with the streamline oct system.

this is a multi-center, post-market, retrospective study design to collect safety and performance data for patients implanted with the streamline oct system. the study will include a minimum of 58 patients at a minimum of 3 sites in the united states. the study will enroll at a minimum of 5 subjects implanted with the occipital plate.

Eligibility criteria:
inclusion criteria: * subject must have had an implant of the oct system. exclusion criteria: * no exclusion criteria.
an efficacy and safety profile of inhaled tv48108 in healthy volunteers and copd patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the primary objective of the study is to characterize the safety profile and duration of bronchodilation of a single dose of inhaled tv48108.


Eligibility criteria:
inclusion criteria: stage 1 (healthy volunteers) * male or female 20 to 75 years of age, inclusive, weighing 50 to 80 kg with a body mass index (bmi) of less than 30 kg/m\^2. * in good health as determined by medical and psychiatric history, physical examination, electrocardiogram (ecg), serum chemistry, hematology, urinalysis, and serology. * other criteria apply, please contact the investigator for more information stage 2 (chronic obstructive lung disease (copd) patients) * male or female; 40 to 75 years of age, inclusive with a minimum body weight of 40 kg * current or former cigarette smokers with a history of cigarette smoking of ≥10 pack years at the screening visit * diagnosis of copd as defined by the global initiative for chronic obstructive lung disease guidelines. * other criteria apply, please contact the investigator for more information exclusion criteria: stage 1 (healthy volunteers) * history or current evidence of a clinically significant or uncontrolled disease * any disorder that may interfere with the absorption, distribution, metabolism or excretion of study drugs. * history of severe allergy to milk protein * active smokers or former smokers who quit within 3 months of the first dose of study drug. former smokers with greater than five-pack years (ie, the equivalent of one pack per day for five years) are also excluded. * other criteria apply, please contact the investigator for more information stage 2 (chronic obstructive lung disease (copd) patients) * recent history of hospitalization due to an exacerbation of airway disease within 3 months * need for increased treatments of copd within 6 weeks prior to the screening visit * history of and/or current diagnosis of asthma * known α1 antitrypsin deficiency, active lung infections (such as tuberculosis or pneumonia), and lung cancer are absolute exclusionary conditions * other criteria apply, please contact the investigator for more information

Keywords: copd bronchodilation
endometrial injury for assisted reproduction

Conditions: Infertility

Summary: the objective of this study is to evaluate the effect of endometrial injury performed prior ovulation induction for assisted reproductive techniques main outcomes.


Eligibility criteria:
inclusion criteria: * women who will start assisted reproductive techniques with planned fresh embryo transfer. * age between 18 and 38 years. * written informed consent. exclusion criteria: * none

Keywords: reproductive techniques embryo implantation endometrium ultrasonography