in-use tolerance study under dermatological and ophthalmological controls and efficacy assessment (face cream)

Conditions: Hypersensitive; Reactive and Intolerant Skin; Redness-prone Skin; Stinger Subjects

Summary: the aim of this study is to assess the dermatological and ophthalmological tolerance of the investigational product crème visage / face cream rv4941a - ry1987 after 21 days of twice daily use on the study areas, under normal conditions of use. the aim of this study is also to: * evaluate the cutaneous sensitivity by a stinging test at d1 t0 and d22. * evaluate the cutaneous sensitivity by a sensitive scale at d1 t0, d1 timm\*, d8 and d22. * evaluate the soothing efficacy by an efficacy questionnaire at d1 timm\*, d8 and d22. * evaluate the cosmetic acceptability by a questionnaire at d22. this study is conducted as a national, monocentric, non-randomized open trial. the 33 subjects in this study present hypersensitive, reactive and intolerant skin on face. they are stinger subjects, with a normal to combination skin. timm\*: 10 to 30 minutes after first application

this study is a national, monocentric, non-randomized open trial, conducted in adults presenting hypersensitive, reactive and intolerant skin on the face, with a normal to combination skin. the study includes 3 visits, including subjects' selection: * v1: baseline inclusion * v2: 1 week, intermediate visit * v3: 3 weeks, study end the maximal study duration is 25 days. the evaluation is at 3 times: d1 baseline, d8 at 1 week and d22 at 3 weeks of application of rv4941a - ry1987 with comparison of each time versus baseline. there are twice-daily applications (morning and evening) of the test product on the face.

Eligibility criteria:
inclusion criteria: 1. criteria related to the population: * male or female aged between 18 and 65 years included * asian population (chinese origin) * normal to combination skin on the face * subject with phototype i to iv included * subject having signed his/her written informed consent for his/her participation in the study * subject who is currently not participating in another clinical study * subject affiliated to a social security system or health insurance, or is a beneficiary * for woman of childbearing potential: use of an effective method of contraception and using it during the whole duration of the study 2. criteria related to diseases and general health: * stinger subjects (evaluated by a stinger test) * subject with hypersensitive, reactive and intolerant skin on face * subject having a score superior to 4 on a sensitive scale for tightness parameter on the face * subject having a score superior to 4 on a sensitive scale for general discomfort parameter on the face exclusion criteria: 1. criteria related to the population: * for woman of childbearing potential: subject pregnant or breastfeeding or planning to be pregnant during the study * having a dermatological condition liable to interfere with the study data or considered by the investigator hazardous for the subject or incompatible with the study requirements * having an ophthalmological condition liable to interfere with the study data or considered by the investigator hazardous for the subject or incompatible with the study requirements * having personal medical history liable to interfere with the study data for the subject or incompatible with the study requirements * having history of abnormal reactions from exposure to sunlight * having taken any previous treatment considered by the investigator liable to interfere with the study data or incompatible with the study requirements * being under any treatment considered by the investigator liable to interfere with the study data or incompatible with the study requirements * subject who is not likely to be compliant with study-related requirements * subject deprived of freedom by administrative or legal decision or under guardianship 2. criteria related to investigational product application areas: * having had any surgery, chemical or significant invasive dermo-treatment on the experimental area considered by the investigator liable to interfere with the study data, before the inclusion visit or foreseeing it for the duration of the study * having applied a skincare or make up product on the study areas the day of the inclusion visit. the usual cleanser is allowed * having received, on the study areas, artificial uv exposure or excessive exposure to natural sunlight within the 2 weeks before the inclusion visit (at investigator's opinion)

Keywords: hypersensitive skin discomfort sensations asian skin sensitivity reduction