Kornimate/medical-research-clean huggingface dataset:
phoenix exoskeleton for sci users

Conditions: SCI - Spinal Cord Injury

Summary: this study will evaluate the phoenix device for safety and effectiveness at allowing persons with sci who are non-ambulatory or poorly ambulatory to stand up and walk under a variety of conditions.


Eligibility criteria:
inclusion criteria: 1. 18 years of age or older in general good health 2. weigh no more than 220lbs 3. skin must be healthy where it touches the phoenix 4. able to stand using a device such as a standing frame 5. have enough strength in your hands and shoulders to support yourself standing and walking using crutches or a walker 6. have good control of upper body 7. determined to have enough bone health to walk full weight bearing without risk of fracture. meeting of this condition is at the discretion of your personal md 8. passive range of motion (prom) at shoulders, trunk, upper extremities and lower extremities within functional limits for safe gait and use of appropriate assistive device/stability aid 9. hip width no greater than 18" (46 cm) measured when sitting. 10. femur length between 12.3 inches (31.3 cm) and 19.8 inches (50.2 cm) measured between centers of hip and knee joints. 11. tibia length between 13.4 inches (33.9 cm) and 22 (55.9 cm) inches measured between the knee joint and bottom of the foot. 12. in general good health and able to tolerate moderate levels of activity. 13. blood pressure and heart rate within established guidelines for locomotive training: at rest; systolic 150 or less diastolic 90 or less and heart rate 100 or less exercise; systolic 180 or less diastolic 105 or less and heart rate 145 or less exclusion criteria: * 1. pregnant or lactating females 2. spinal cord injury level higher than t4 3. severe muscle stiffness/tightness 4. significant spasticity (modified ashworth scale score of 3 or above) 5. trunk or lower extremity pressure ulcer 6. open wounds 7. unstable spine, un-healed limbs, or fractures 8. severe sensitivity to touch 9. presence of bone in soft tissue where bone normally does not exist (heterotopic ossification), limiting range of motion in the hip or knee joints 10. joint instability, dislocation, moderate to severe hip dysplasia 11. significant scoliosis (\>40 degrees) 12. hardware, implant, or any external device impeding with safe fitting or use of phoenix 13. femoral or tibial rotation deformity (\>15 degrees) 14. significant flexion contractures limited to 35º at the hip and 20º at the knee 15. uncontrolled seizures, musculoskeletal injury, fracture or lower-limb surgery in past year. 16. known history of pulmonary disease limiting exercise tolerance or history of cardiac disease 17. psychopathology, or other condition that the physician or investigator, in his or her clinical judgment, considers to be exclusionary to safely use an exoskeleton. 18. severe concurrent medical diseases, illness, systemic or peripheral infection 19. dizziness or headache with standing 20. history of autonomic dysreflexia 21. orthostatic hypotension: decrease in systolic bp \> 20, diastolic bp \> 10 upon standing from a seated position.
impact of behavioral factors on treatment adherence in a sample of rheumatoid arthritis patients

Conditions: Arthritis, Rheumatoid

Summary: rheumatoid arthritis (ra) care has been revolutionized in the last decade with the advent of biotherapies. only 66% of treated patients are compliant. nevertheless, studies analyzing the medication adherence in ra are rare. the aim of this study is thus to evaluate ra treatment adherence considering demographic data, vaccination coverage, feeding behavior and the use of e-health tools.

rheumatoid arthritis (ra) care has been revolutionized in the last decade with the advent of biotherapies. the success of this therapeutic strategy is based on several factors, including the medication adherence. whatever the method used, adherence evaluation is not sufficient, around 66% of the treated patients. nevertheless, studies analysing the predictive factors of medication adherence in ra are rare. ra patients are also educated about the infectious risk related to ra and treatments, and the importance of vaccination. these recommendations are not always respected by the patients, without knowing the exact factors leading to this decision. furthermore, a lot of patients take personal initiatives without the agreement and the help of their practitioner, like diets or special feeding behaviors. lastly, plenty of patients affected bv chronic diseases claim and use electronic health tools without any real evidence of the efficacy of such device. the aim of this study is thus to evaluate ra treatment adherence considering demographic data, vaccination coverage, feeding behavior and the use of e-health tools.

Eligibility criteria:
inclusion criteria: * patient aged over 18 years old, * affected by ra according to acr/eular 2010 criteria, * francophone, * and informed about the aims of the study. exclusion criteria: * guardianship patient, * patient who refuses to participate.

Keywords: rheumatoid arthritis medication adherence vaccination coverage electronic health tools diet
run daddy run! a lifestyle intervention focusing on fathers and their children

Conditions: Father-Child Relations

Summary: the aim of this study is to develop and implement a multicomponent ehealth lifestyle intervention (focusing on (co-) physical activity and screen time) for fathers and their children, aiming to prevent childhood overweight and obesity.

the run daddy run project aims to develop an effective lifestyle intervention for belgian fathers and their primary school-aged children, to prevent overweight and obesity. there is focused on increasing (co-) physical activity and limiting individual and joint screen time. the project specifically targets fathers and their children because the literature shows that now often only mothers participate in lifestyle interventions, and fathers are underrepresented and difficult to involve. however, fathers play an important and unique role, independently of the mother, in shaping the child's behavior. the run daddy run intervention was developed based on the intervention mapping protocol, a theoretical framework that is often used to develop interventions in a systematic way using empirical evidence and theoretical insights. a co-creation approach was also used for the intervention development, which is a bottom-up approach in which the target group (fathers in this case) is actively involved in the development of the intervention. the result of this approach is contextually appropriate intervention and intervention strategies.

Eligibility criteria:
inclusion criteria: * fathers * primary school aged children exclusion criteria: - unhealthy/disease

Keywords: obesity fathers children primary school intervention physical activity screen time sedentary behaviour
role of ultrasound in diagnosis of muscle diseases

Conditions: Ultrasound; Muscle Disease

Summary: the study aims to provide a timely update on the role of combining clinical and neuromuscular ultrasound assessments in diagnosis and follow-up of various muscle diseases in clinical practice over 12 months period, and correlating us findings with functional scales, biochemical and electrophysiological studies.

many muscle diseases share common clinical features that render arriving at appropriate diagnoses difficult. the combination of muscle imaging with clinical can limit the differential diagnosis and yield the most probable one and can direct genetic testing as the only method to arrive at a definite diagnosis. in recent years, the use of high-resolution ultrasound had become an important tool in diagnosis and in the monitoring of disease progression and treatment of both hereditary and acquired myopathies. additionally, it entails a safe, accessible, low-cost, and no ionizing radiation tool which renders the technique extremely suitable for paediatric patients and patients who cannot lie still without sedation. therefore, it can be used as a complementary tool to electro-diagnosis. ultrasound permits to evaluate echo intensity, muscle perfusion, transverse and longitudinal sections of the muscle and its thickness at rest and during maximal voluntary contractions, overlying subcutaneous fat, cross-sectional area, and angled fibers of pennate muscles. the use of sonographically guided biopsy is an easy, safe, and reliable method for attaining tissue for histologic diagnosis in neuromuscular disease. in most myopathies, either acute or chronic, muscle tissue undergoes morphological changes giving rise to replacement of muscle by connective tissue and/or fat. pattern recognition on muscle imaging might be helpful in distinguishing between different disease entities.

Eligibility criteria:
inclusion criteria: * males and females. * 2-60 years old. * for patients with acute inflammatory myositis: patients presenting with characteristic picture of acute inflammatory myositis according to the myositis association 2019. * for patients with acute inflammatory myositis: newly diagnosed patients within one month from onset of disease. * all patients not received any previous specific treatment for myopathy. exclusion criteria: * patients with clinically or electrophysiologically suspected other neuromuscular conditions that mimic myopathy such as motor neuron disease, neuromuscular junction disorders. * patients with secondary causes of myopathies; as drug induced, endocrinal disorders like diabetes mellitus and hypothyroidism or metabolic myopathy. * patients who received any previous specific treatment for myopathy

Keywords: ultrasound muscle electrophysiology
prognostic impact of adjuvant therapy in primary hepatic sarcomatoid carcinoma

Conditions: Sarcomatoid Carcinoma; Liver Cancer; Adjuvant Therapy

Summary: in recent years, researchers have conducted extensive studies on adjuvant therapy following surgical resection of liver cancer, exploring its potential benefits and seeking effective treatment strategies. given the rarity and high aggressiveness of primary hepatic sarcomatoid carcinoma, there is a lack of reliable clinical evidence on whether postoperative adjuvant therapy can benefit patients, resulting in the absence of established standard guidelines. therefore, we conducted a single-center retrospective study to assess the potential benefits of postoperative adjuvant therapy for patients of primary hepatic sarcomatoid carcinoma.


Eligibility criteria:
inclusion criteria: 1. patients who underwent liver resection 2. patients' postoperative paraffin pathology and immunohistochemistry results were reviewed to identify those diagnosed with phsc exclusion criteria: 1. patients who received other anti-tumor treatments before surgery, such as radiofrequency ablation (rfa), transarterial chemoembolization (tace), radiation therapy (rt), and systemic therapy; 2. patients diagnosed with other specific types of sarcomas; 3. patients with concurrent other malignancies during the course of phsc; 4. patients who were lost to follow-up or lacked essential clinical data.
early prevention of conduct problems

Conditions: Conduct Disorder

Summary: the purpose of this study is to examine the immediate and long-term effects of a prevention program in children at risk for developing conduct problems and antisocial behavior.

participants are randomly assigned to a year-long family-based intervention or to a no contact control group. the intervention focuses on improving parenting practices, parent-child interactions, and child social competence. children are assessed at the beginning of the study and again after one year. the development of conduct problems, social competence, and school functioning is assessed from second through fifth grade. assessments are made through observations, parent and teacher ratings, and diagnostic interviews.

Eligibility criteria:
inclusion criteria: * sibling of youth adjudicated in family court

Keywords: social behavior disorders
outcomes from remediation and behavioural intervention techniques

Conditions: Schizophrenia; Psychosis; Psychotic Disorders; Schizophrenia; Psychosis

Summary: it is currently unknown what factors predict response to cognitive behavioural therapy for psychosis (cbtp) or cognitive remediation therapy (cr) among individuals with schizophrenia-spectrum disorders, thus the current trial will examine predictors of response to determine who requires the combined intervention and who might respond sufficiently to either monotherapy.

dominant treatment approaches for schizophrenia-spectrum disorders improve psychiatric symptoms but do little to improve community functioning, leading to persistent disability and substantial economic burden. the proposed trial aims to examine the efficacy of a multi-mechanism approach to combining cbt and cr with the goal of predicting treatment response to either monotherapy or combination therapy. to date, there have been no randomized controlled trials examining the combination of cbt and cr. given the differential mechanisms of cbt and cr, the combined multi-mechanism approach is expected to more effectively improve functional recovery than either monotherapy. additionally, it is currently unknown what factors predict response to cbt or cr, thus the current trial will examine predictors of response to determine who requires the combined intervention and who might respond sufficiently to either monotherapy. the proposed trial will be one of the largest trials of psychosocial interventions for schizophrenia-spectrum disorders ever conducted and will simultaneously evaluate the combined intervention and moderators of differential treatment response. narrower fields of inquiry examining mono-mechanism interventions have demonstrated little utility in improving functional recovery in schizophrenia, thus, the proposed approach represents a critical advancement by examining the utility of a multi-mechanism cognitive intervention and determining characteristics of those requiring this level of treatment. the goals of the current study are three-fold: 1. examine the efficacy of combining cbt and cr on the primary outcome of community functioning, and secondary outcomes of quality of life, personal recovery, psychiatric symptoms, and neurocognition compared to either intervention alone. 2. examine demographic, cognitive, and psychological factors that predict differential response to cbt, cr, or combined cbt and cr. 3. examine the specificity of cognitive content and cognitive functions as therapeutic mechanisms in cbt and cr respectively.

Eligibility criteria:
inclusion criteria: * aged 18-65 years * diagnosed with schizophrenia-spectrum disorders * can read, write, and speak english exclusion criteria: * neurodevelopmental disability or neurocognitive disorder * cbt or cr in the past 6 months
the 'lombard effect' in patients affected by adductor laryngeal dystonia

Conditions: Adductor Spasmodic Dysphonia

Summary: adductory spasmodic dysphonia (adsd) is a rare condition characterised by irregular and uncontrolled voice interruptions, most commonly affecting women around the age of 45. the diagnosis is clinical and usually requires evaluation by several specialists. the exact cause is not known, but a disturbance of the motor system is hypothesised, probably related to various causes such as loss of cortical inhibition or problems with sensory input. neuroimaging studies have shown hyperactivity in various brain regions during speech production in patients with adsd, but it is still unclear whether this hyperactivity is due to a malfunction of auditory and somatosensory feedback or an impairment of motor programming. recent research indicates that patients with adsd show excessive muscle activation during phonation, probably due to abnormal processing of auditory feedback. this suggests that intervention in the auditory system may offer new treatment opportunities. the proposed study aims to describe the acoustic, auditory-perceptual and subjective voice and speech changes in adsd subjects during the quick-lombard test (lt), a test that assesses vocal response under noisy conditions.


Eligibility criteria:
inclusion criteria: * native italian-speaking patients; * normal hearing, hearing threshold \&lt; 20 db hl for frequencies from 0.5 to 4 khz; * age \&gt;18 years and \&lt;65 years; * written informed consent. exclusion criteria: * non-italian-speaking patients. * patients undergoing treatment for dystonia. * previous laryngeal surgery. * patient undergoing speech therapy. * patient undergoing dopaminergic therapy. * inability to sustain phonation of sufficient duration \&gt;3 seconds or to perform sufficient tests to assess vocal outcomes. * lack of written informed consent.

Keywords: laryngeal dystonia spasmodic dysphonia lombard effect auditory system
triad appendicitis decision-making surveys

Conditions: Appendicitis

Summary: while appendectomy has been the main treatment of appendicitis for over 100 years, recent european studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative. surgeons and patients alike have a difficult time deciding if surgery or antibiotics are the best choice to treat appendicitis. the goal of the triad is to evaluate the patients who are a part of the triad implementation program and assess satisfaction and decisional regret for patients with appendicitis. this information will be used to inform the design of decision-support interventions to help patients improve their ability to make an informed decision in-line with their preferences and values.

triad patient surveys is a cross-sectional survey design that will lead to more informed decision making and better outcomes related to antibiotics for appendicitis. triad was developed from questions raised by the university of washington coda trial that addressed many of the methodological issues in the european studies and included diverse, adult patients (n=1552) with almost all types of presentations of appendicitis. triad surveys will be carried out in clinics and hospitals across the united states. patients who are diagnosed with appendicitis will be recruited for study participation regardless of which treatment (appendectomy or antibiotics) they receive. investigators invite patients to participate in a survey designed to identify awareness of treatment options and levels of decisional conflict (measured with the ottawa decisional conflict score \[dcs\]). participants will complete a baseline survey via a convenient electronic platform, and follow-up surveys will be sent at 30 days. by implementing the triad surveys, researchers hope to obtain a better understanding of patients' perspectives, knowledge, and decision-making processes regarding the choice between appendectomy and antibiotic treatment for appendicitis. this data can contribute to more informed decision-making and potentially improve outcomes related to antibiotic use for this condition.

Eligibility criteria:
inclusion criteria: * any patient the clinical team feels is appropriate for considering either surgery or antibiotics for their initial appendicitis treatment exclusion criteria: * pregnant patients * immunocompromised patients * patients with high complication risk of recurrent infections * evidence of severe phlegmon or walled off abscess or free air on imaging * septic shock * diffuse peritonitis * patients under 18 years old

Keywords: decision support tool implementation antibiotics surgery
an investigational study to test usability of the electronic dosing equipment medicpen

Conditions: Crohn's Disease; Ulcerative Colitis

Summary: this is a study of the electronical dosing tool medicpen and it's qualities with regards to user friendliness and medication compliance.

the medical device medicpen will be investigated for it's qualities with regards to medication compliance and user friendliness. the patient group selected here is patients with crohn's disease that are treated with azathioprine. the patient selection was made since the metabolite can be easily measured and the compliance can be therefore be followed. the treatment will follow the standard care given to these patients.

Eligibility criteria:
inclusion criteria: * male or female * 18 years or older * provided written informed consent * diagnosed with chron's disease or ulcerative colitis * treated with azathiprine for at least 6 months prior to study start exclusion criteria: * patients who are, for some reason, judged by the responsible investigator to be unable to handle the device to be tested.

Keywords: dosing tool compliance user friendly crohn's disease ulcerative colitis
phase ii trial of thalidomide in refractory/relapsed diffuse large b-cell lymphoma and hodgkin's disease

Conditions: B-Cell Lymphoma; Hodgkin's Disease

Summary: patients who have relapsed or refractory large b-cell lymphoma are being asked to take part in this study. the purpose of this study is to find out what effects (good and bad) the drug thalidomide has on patients and the lymphoma.

patients who have relapsed or refractory large b-cell lymphoma are being asked to take part in this study. this research is being done because current treatment does not help everyone with this disease. the purpose of this study is to find out what effects (good and bad) the drug thalidomide has on patients and the lymphoma. thalidomide has been shown to have activity against other cancers but is not approved by the fda for treatment of lymphoma. thalidomide prevents growth of new blood vessels that allow cancer cells to receive nourishment and spread. another reason for doing the study is that researchers want to learn more about how the drug works and whether some patients respond better than others.

Eligibility criteria:
inclusion criteria: * patients with an expected survival period of 6 months or greater and who have been diagnosed with any stage of diffuse large b-cell lymphoma or hodgkin's disease will be eligible to participate in this study. final eligibility will be determined by the health professionals conducting this trial. exclusion criteria: * women who are pregnant, lactating or who refuse to have a pregnancy test will not be eligible for this study. also, patients with an active infection, or a history of current or previous deep vein thrombosis and/or currently receiving anticoagulant therapy for deep vein thrombosis will be excluded from participation in this study. final eligibility will be determined by the health professionals conducting this trial.

Keywords: b-cell lymphoma hodgkin's disease
peep-induced changed in rri as physiological background of ventilator-induced kidney injury

Conditions: Respiratory Distress Syndrome, Adult; Respiration, Artificial; Acute Kidney Injury

Summary: the renal doppler resistive index (rri) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (icu) setting. many parameters have been described as influential on the values of renal ri. mechanical ventilation is associated with significant increases in the risk of acute kidney injury (aki). ventilator-induced kidney injury (viki) is believed to occur due to changes in hemodynamics that impair renal perfusion. the investigators hypothesized that patients who need mechanical ventilation should have a different response in rri when different levels of positive end expiratory pressure (peep) are applied. investigators wish to describe changing in rri due to changes in peep and to verify whether these changes could partially explain the occurrence of viki


Eligibility criteria:
inclusion criteria: * patients admitted to icu with expected mechanical ventilation \>48h exclusion criteria: * ultrasound rri evaluation non available * patients with arrhythmia * pregnancy