Kornimate/medical-research-clean huggingface dataset:
the role of manual twirling acupuncture in reducing muscle pain and stiffness after biceps curling in healthy untrained individuals

Conditions: Muscle Soreness; Stiffness of Elbow, Not Elsewhere Classified

Summary: regular physical activity can help to prevent and control non-communicable disease. who recommends at least in adults to do moderate-vigorous physical activity includes muscle strengthening. but regardless the importance and recommendations of physical activity, not all of the world's population does it .biceps curling is a popular physical exercise which easy to do , it can strengthen the muscles in the upper body. however based on the international association for the study of pain (iasp) in individuals who just starting to do physical exercise may experience pain and can become a barrier to do physical activity, so an approach is needed to prevent this and acupuncture is one of them. currently, a lot of acupuncture research has been carried out to reduce the condition pain and stiffness after weight training, but there are not many study using manual acupuncture twirling in this condition . that's why the aim of this study is to see the efficacy of giving manual acupuncture with twirling stimulation for pain and stiffness post weight training. the study method will be a single blinded crossover randomized controlled trial which will compare the efficacy of manual acupuncture twirling with manual acupuncture sham for post-exercise pain and stiffness . the outcomes consist of visual analog scale, pain pressure threshold, range of motion of elbow flexor at 24 hours, 48 hours, and 72 hours post weight training

this is a clinical trial study with cross-over design with 1 week wash out period to evaluate and compare the effects of manual acupuncture twirling and manual acupuncture sham for pain and stiffness after biceps curling (weight training) on healthy untrained subjects. the subjects are 48 males/female and will be randomly assigned to 2 groups: (1) manual acupuncture twirling/manual acupuncture sham and (2) manual acupuncture sham/manual acupuncture twirling group . the subjects will receive two times treatment on day 1 and day 7. the outcome will be assessed each before treatment (baseline) at 24 hours, 48 hours, and 72 hours post weight training. patients and the outcome assessors will be blinded to the group allocation.

Eligibility criteria:
inclusion criteria: * healthy individuals with no exercise program * elligible for physical exercise * willing to take part in the study and sign informed consent exclusion criteria: * consuming anti-inflammatory drugs, muscle relaxants and received any type of acupuncture within 7 days before the study * having contraindications of manual acupuncture (pregnant, malignancy, bleeding disorders, needle phobia)
ultrasound-guided corticosteroid and bupivacaine for facial nerve function and thickness in bell's palsy

Conditions: Bell&#39;s Palsy

Summary: this prospective, single-arm clinical study aims to evaluate the effects of a one-time, ultrasound-guided injection of corticosteroid (triamcinolone) combined with local anesthetic (bupivacaine) into the facial nerve in patients with acute bell's palsy. the injection is administered approximately 1.5-2 cm after the nerve exits the stylomastoid foramen, with precise targeting using ultrasound imaging. a total of 40 adult participants diagnosed within 72 hours of symptom onset will be enrolled. the primary outcome is improvement in facial nerve function, assessed using the house-brackmann facial nerve grading system at day 7, day 15, and 3 months post-injection. secondary outcomes include changes in facial nerve thickness measured by ultrasound before and one week after the procedure. this is the first clinical trial to directly evaluate targeted facial nerve injection as a potential treatment approach in bell's palsy.


Eligibility criteria:
inclusion criteria age between 18 and 70 years diagnosis of acute bell's palsy within the past 72 hours house-brackmann grade iii or higher willing and able to give informed consent able to attend all follow-up assessments exclusion criteria: history of chronic facial nerve disorders known allergies to corticosteroids or local anesthetics coagulopathy or current use of anticoagulant therapy mri or ct findings indicating alternative causes of facial nerve palsy (e.g., tumor, stroke, ms) pregnancy or breastfeeding participation in another interventional clinical trial -
an investigational drug in patients with osteoarthritis (0663-073)

Conditions: Osteoarthritis

Summary: this study was conducted to assess the safety and tolerability of an investigational drug and to evaluate its effectiveness in the treatment of osteoarthritis of the hip or knee in both men and women.

the duration of treatment is 12 weeks.

Eligibility criteria:
inclusion criteria: * patients with osteoarthritis of the hip or knee who use current approved medication (nonsteroidal anti-inflammatory drugs (nsaids)) or tylenol to treat the symptoms of their osteoarthritis. patients taking nsaids are required to discontinue using these drugs and their symptoms must become worse. exclusion criteria: * patients with certain medical conditions may not be allowed to participate. these conditions will be reviewed with the study physician.

Keywords: arcoxia
non-interventional local study on prescription behavior of anticoagulation therapy in secondary stroke prevention in atrial fibrillation patients

Conditions: Stroke; Embolism

Summary: this is local prospective multicenter observational non-interventional local study. primary study objective is investigate and describe prescription pattern of neurologists in secondary stroke or non-cns (non-central nervous system) systemic embolism prevention in patients with af (atrial fibrillation) and prior stroke or tia (transient ischemic attack) who treat with rivaroxaban at an initial visit and three follow-up visits.


Eligibility criteria:
inclusion criteria: * male and female patients ≥ 18 years old who start treatment with rivaroxaban * non-valvular atrial fibrillation is documented in patients' file * prior tia/stroke history * tia - more than 72 hours after documented tia * more than 2 weeks after non-hemorrhagic stroke * written informed consent exclusion criteria: * contraindications for use of xarelto® in accordance with approved product label * previous thromboprophylaxis treatment with anticoagulants prior toby reason of stroke / tia prevention * any reasons of medical and non-medical character, which in the opinion of the physician can hamper patient participation in nis

Keywords: non-interventional rivaroxaban prevention in prior stroke or tia russian federation
anesthetic efficacy of articaine and lidocaine in lower molars with irreversible pulpits

Conditions: Irreversible Pulpitis; Pain

Summary: the aim of this study was to verify the effectiveness of an anesthetic called articaine for dental treatment, comparing it with an anesthetic commonly used in dental clinic: lidocaine. two types of local anesthesia (oral injection) in accordance with the solution used were performed. for patients anesthetized with articaine, an injection of anesthesia close to the tooth to be treated was used. for the anesthetic lidocaine an injection on the cheek at the bottom of the mouth was made. differences between both techniques are mainly regarding the area of numbness. in the injection with articaine only a small part of the lip and the tooth was anesthetized. with lidocaine injection, the lower region of the entire side of the tooth and half of the tongue on the same side was numbed. the treatment was electronic randomized and there was equal chance to one or another treatment. the investigators are studying this new form of anesthesia (near the tooth that was treated) to see if it can numb the tooth to an emergency treatment, if it really decreases the feeling of numbness and discomfort during the service. patients receiving articaine were submitted to cone beam exam at no cost.

aim: this randomized clinical trial compared the anesthetic efficacy of buccal infiltration (bi) with 4% articaine (ar) and inferior alveolar nerve block (ianb) with 2% lidocaine (li), both with 1:100,000 epinephrine, in symptomatic mandibular molars with irreversible pulpitis. likewise, we compared the efficacy of the primary infiltration (bi or ianb) with one supplemental injection (intraligamentary infiltration with articaine for ar and bi with articaine for li). the influences of buccal cortical bone thickness and root distances to buccal cortical bone on articaine performance (ar) were also evaluated using cone-beam tomography. methodology: volunteers presenting symptomatic mandibular molars with irreversible pulpitis were randomly divided into two groups (30 for ar and 20 for li). success was recorded when complete pain-free treatment was achieved after primary injection or when one supplemental injection was needed for emergency endodontic procedures.

Eligibility criteria:
inclusion criteria: * long-lasting moderate to severe pain during cold test * absence of periapical radiolucency except for a widened periodontal ligament (evaluated in periapical radiographs) * vital coronal pulp on access opening exclusion criteria: * previous history of allergy to local anesthetics * subjects with systemic diseases * pregnancy and lactation * subjects taking any kind of medication that could change or influence the outcome of this research * subjects without painful symptoms * negative thermal testing, periapical lesion, incomplete root formation, presence of fistula or abscess, cracks or fractures

Keywords: pulpitis hot tooth articaine lidocaine local anesthetics
clinical trial of green tea catechins in men on active surveillance

Conditions: Prostate Cancer; Prostate Adenocarcinoma

Summary: this randomized double-blinded phase ii clinical trial will evaluate the bioavailability, safety, effectiveness and validate the mechanism by which a standardized formulation of whole green tea catechin, (sunphenon® 90d) containing 405 mgs vs. placebo, administered for 24 months in a cohort of men with low to intermediate grade prostate managed on active surveillance


Eligibility criteria:
inclusion criteria: * 18 years of age or older * biopsy-proven (consisting of ≥ 12 tissue cores) adenocarcinoma of the prostate with cancer present in at least one biopsy core (trus or/and mpmri/trus fusion), gleason score (3+3) or predominant gleason pattern 3 (3+4), ≤ 33% of biopsy cores, and ≤50% involvement of any biopsy core (participant meets all criteria for active surveillance as determined by md) * willing to start or continue on active surveillance * baseline/screening serum psa \<10 ng/ml * no other prior treatment for pca, including focal therapy * ecog performance status 0-1 * no history of renal or hepatic disease, including history of hepatitis b and c * meet hematological eligibility parameters (neutrophil count ≥ 1,200/mm3 (≥1.2 k/μl), stable platelet count ≥ 75,000/mm3 (≥ 75k/μl) hepatic and renal function eligibility parameters, serum total bilirubin ≤uln (uln: 1.2 mg/dl) (or ≤3.0 mg/dl for patients with gilbert's syndrome), ast or alt \<1.5x uln and serum creatinine ≤1.5 x uln * willing to abstain from consumption of any supplements containing gtc * willing to restrict tea consumption to less than three (3) servings of hot tea or three (3) servings of iced tea per week * willing to discontinue current vitamin/mineral supplement use and use one provided by study * willing to take study agent or placebo at the dose specified with meals. exclusion criteria: * have had prior treatment for pca by surgery, irradiation, local ablative (i.e., cryosurgery or high-intensity focused ultrasound), or androgen-deprivation therapy) * men who are currently treated or those treated in the past 3 months prior to day of randomization with 5- alpha-reductase inhibitors (e.g., finasteride, dutasteride) * participants who have pca with distant metastases * participants who have been treated with: hormone therapy, immunotherapy, chemotherapy and/or radiation, for any malignancies within the past 2 years prior to registration.patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. all patients with metastatic disease will be excluded * participants may not be receiving any other investigational agents * history of allergic reactions attributed to tea or compounds of similar chemical or biologic composition to green tea extracts.

Keywords: prostate green tea green tea catechins
a low-dose radiation and contrast agent exposure protocol for coronary cta in diabetic patients

Conditions: Coronary Artery Disease

Summary: to assess diagnostic accuracy,image quality and renal safety of a double low-dose coronary cta protocol at coronary artery evaluation in patients with diabetes by using invasive coronary angiography(ica) as the reference method and to compare the results with those obtained traditional dose protocol. the study will randomly include about 400 consecutive participants aged 18 to 80 years old who had been diagnosed with diabetes and suspected coronary artery disease.all participants undergo ica and coronary ct angiography performed with a whole-heart ct scan.coronary segment interpretability,image quality based on a four-point likert scale,blood indicators of renal function will be accessed between double low-dose cta protocol and traditional cta protocol. investigators hypothesize that an individualized coronary cta protocol that appropriately reduces radiation dose and contrast dose does not affect image quality and diagnostic accuracy, and can reduce the risk of kidney damage in high-risk patients.

the study has been approved by the local ethics committee and allparticipants will be provided written informed consent. iodixanol 320 mg/ml is injected followed by 30 ml of saline solution.in the test group,the tube voltage,contrast agent volume and flow rate are adapted to cardiac ejection fraction(ef) and body mass index(bmi)according to the pretest. participants in the contract group are injected 50 ml contrast agent with the flow rate of 5 ml/s in tube voltage of 120 kvp. all participants are scanned in automatic tube current.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old and ≤ 80 years old; * patients who have previously diagnosed diabetes; * patients with suspected coronary artery disease and undergoing coronary ct angiography (cta); * subjects are fully informed and provided written informed consent. exclusion criteria: * the exclusion criteria are pregnancy and lactation women or recent birth planners * patients with iodine contrast agent contraindications (such as a history of severe allergy history with iodine contrast agents, hyperthyroidism, etc.) * patients with chronic kidney disease (phase 4-5, egfr \<30 ml/min/1.73 m2) * patients who have undergone coronary stent implantation or coronary artery bypass surgery * patients who have received iodine contrast-related tests within 24 hours * participated in other clinical trials within 3 months * other circumstances that the investigator believes are not suitable for participation in the trial

Keywords: coronary ct angiography iodixanol diabetes diagnosis
outcomes in hepatitis c after living donor liver transplantation in association with interleukin 28 b

Conditions: Hepatitis C

Summary: hepatitis c is the leading cause of liver transplants in the usa. given that there is a national organ shortage, living donor liver transplantation has became a viable option for patients with end stage liver disease who are not severely ill. recently particular polymorphisms of il-28b gene were reported to correlate with histological recurrence and antiviral treatment response after orthotopic liver transplantation for hepatitis c. similar results have not been described yet in living donor liver transplant patients. there is data suggesting slightly inferior outcomes in living donor liver transplants when done for hepatitis c. the investigators postulate that such inferior outcomes may be related to il28 polymorphism concordance (i.e., unfavorable recipient polymorphism patients receive similarly unfavorable polymorphism livers from their relatives).


Eligibility criteria:
inclusion criteria: * patients who received a living donor liver transplant for chronic hepatitis c who are 18 year or older * patients who donated part of their liver to patients suffering from chronic hepatitis c. donors must be 18 years or older exclusion criteria: * patients who are not willing to sign the consent * inability to obtain liver specimen (recipients) * inability to obtain blood sample (donors)

Keywords: end stage liver disease living donor liver transplantation hepatitis c interleukin 28b
mitraclip in acute mitral regurgitation

Conditions: Mitral Regurgitation; Acute Myocardial Infarction

Summary: acute mr may develop in the setting of an acute myocardial infarction (ami) as a result of papillary muscle dysfunction or rupture, and these patients are grossly underrepresented in mitraclip registries. our group has recently published the spanish experience with mitraclip in acute mi, but only 5 patients could be collected. however, the results of our initial experience are highly encouraging since patients performed well in such life-threatening condition. in order to expand the information of the device in this condition, our aim is to start a multinational registry in europe.


Eligibility criteria:
inclusion criteria: * patient ≥ 18 year-old * transmural myocardial infarction in the previous 4 weeks (managed under current guideline's recommendations). * symptomatic severe mitral regurgitation diagnosed by left ventriculography, transthoracic echo or trans-oesophageal echo. symptoms may vary form heart failure to cardiogenic shock. * symptoms should be stabilized by medical management: iv diuretics, inotropic support, lv assistance devices * considered by heart team at high risk for conventional surgery exclusion criteria: * anatomy not suitable for mitraclip implantation * technical contraindication for access to left atrium * patient candidate for emergent heart transplant * uncontrolled infection

Keywords: mitraclip acute mitral regurgitation acute myocardial infarction
long-term follow-up in patients affected with acrofacial vitiligo

Conditions: Vitiligo

Summary: acrofacial vitiligo is a clinical form of vitiligo characterized by macules in distal digits, periorificial-facial and ano-genital areas. vitiligo european task force classifies vitiligo as generalized or localized; generalized vitiligo may be further sub-divided into acrofacial, vulgaris and universalis, and localized vitiligo, into segmental and focal. some authors do not believe that acrofacial is a real vitiligo clinical form, considering it as an initial form of vulgaris vitiligo. the aim of this study is to follow early- diagnosed acrofacial patients during ten years in order to define if these patients will maintain this clinical form or will evolute to a more severe clinical form.


Eligibility criteria:
inclusion criteria: 1. patients of both genders, aged older than years, able to understand and provide written informed consent and able to allow compliance at the treatment and the requirements of the protocol; 2. presence of acrofacial vitiligo; 3. able to comprehend and willing to provide written informed consent in accordance with institutional and regulatory guidelines. exclusion criteria: 1- subjects assessed as not suitable for the study in the opinion of the investigator 2 -inability to complete survey
rtms posterior parietal cortex modulation and upper limb movement after stroke

Conditions: Stroke; Hemiparesis; Transcranial Magnetic Stimulation; Brain Connectivity

Summary: this study evaluates the effect of a unique session of inhibitory rtms (ctbs) over the contralesional posterio parietal cortex (ppc) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. it will also assess the effects on the resting motor threshold of both hemispheres and on parietopremotor connectivity. to achieve theses aims, the real ctbs stimulation will be randomly counterbalanced with a sham stimulation (in a second session) in a crossover design. assessments will be performed before and after each stimulation session.


Eligibility criteria:
inclusion criteria: * age between 18 and 80y * right-handed * right hemispheric stroke confirmed by a 3d imaging technique * at the chronic phase (\>6months) * subject being able to perform a pointing movement of at least 20cm in the anterior space without compensatory movements of the trunk * informed consent * social security affiliation exclusion criteria: * severe comprehension troubles (language, cognitive or psychiatric disorders) * history of neurological disorders in addition to the stroke * locomotor troubles affecting the paretic arm * contraindication to rtms : epilepsy, intracranial metallic foreign body, cochlear implant, unstable fracture of the skull bones, deafness * pregnancy or breastfeeding * adult subject to guardianship
acupuncture as pain relief and relaxation during childbirth

Conditions: Acupuncture Analgesia; Natural Childbirth

Summary: the purpose of this study is to investigate the effect of acupuncture for pain relief and relaxation during childbirth.

the purpose of this study is to investigate the effect of acupuncture for pain relief an relaxation during childbirth. in a controlled study 607 healthy patients in active labor at term are randomly assigned to receive either acupuncture, tens or traditional analgesia. pharmacological analgesia is provided on request. the treatment is administered by midwives trained in acupuncture and tens. the objective parameter of outcome is the need for conventional analgesia in each group. visual analogue scale assessments are used to evaluate participants perception of pain before, during and after treatment. questionnaires filled out two months after delivery is used to investigate the patients experience and satisfaction with delivery and analgesia.

Eligibility criteria:
inclusion criteria: * healthy, danish speaking women with a normal singleton pregnancy giving birth at term 37 - 42 weeks) with a fetus in cephalic presentation. exclusion criteria: * women with medical diseases or complicated pregnancy. women who has already received conventional analgesia during labor.

Keywords: acupuncture pain relief labour randomized controlled trial tens
diet and the aging brain

Conditions: Healthy

Summary: we investigate whether a change in diet could provide positive effects on general brain functions in healthy elderly people.

the age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as alzheimer's disease are a growing public-health concern with potentially devastating effects. refering to animal data and empirical studies, a healthy diet rich in unsaturated fatty acids and low in calories should improve cognitive functions such as learning and memory. to test this hypothesis, we study general brain functions in healthy elderly subjects (50-80 years old) during a short term diet.

Eligibility criteria:
inclusion criteria: * healthy subjects * 50-80 years old * moderate to heavy weight * must be able to change diet at home exclusion criteria: * diabetes * younger than 50 years * bmi \< 23 * already participating in other studys * mmse \> 26 * eating disorders

Keywords: diet elderly age-related diseases prevention cognitive decline clinical study