Kornimate/medical-research-clean huggingface dataset:
dietary assessment and prevention of hypertension in nigeria

Conditions: Hypertension; Blood Pressure

Summary: contrary to north america and europe, the prevalence of hypertension is rising in west africa and, currently, there are no simple dietary assessment tools for clinicians to offer personalized dietary support to their patients. this study aims to: 1. evaluate the feasibility and validate the a short dietary screening tool for hypertension for use in nigerian clinics; and 2. test the accuracy and estimate the potential value of the validated short dietary assessment tool in nigeria clinics.

contrary to north america and europe, the prevalence of hypertension is rising in west africa. with a transition from whole foods to processed foods in nigeria, diet is considered a key driver of hypertension. to combat this, the national nutritional guidelines in nigeria were implemented but their translation into actionable tools for clinicians remains a challenge. currently, there are no simple dietary assessment tools that are concise and suitable to be incorporated into clinical care without requiring extensive data analysis while still providing personalized dietary support to their patients. this study aims to deliver a clinically tested and validated short dietary assessment tool for clinicians, patients, and researchers across nigeria to provide personalised dietary advice for patients with hypertension. the study will be conducted in two phases: phase 1 (n=75), will investigate the feasibility of the short ffq and its agreement with 24-hour dietary recalls (3x) in a clinical setting in nigeria. during the analysis of phase 1 data, a scoring system will be developed based on the associations between individual food items in the ffq and measures of hypertension. phase 2 (n=50) will assess the acceptability of the ffq and validate the association between the ffq score and hypertension. we anticipate that the development of a clinically tested and validated short food frequency questionnaire that will be ready for implementation analysis for use by clinicians, patients, and researchers across nigerian that will support the prevention and management of hypertension.

Eligibility criteria:
inclusion criteria: * men and women of generally good health or with hypertension exclusion criteria: * history of chronic diseases such as cardiovascular diseases (heart diseases), stroke, chronic kidney diseases, or pregnant or breastfeeding women, children below 18 years and adults above 70 years are also excluded from this study. additionally, individuals who have made significant changes to their diet in the past six months or are currently following specific dietary restrictions will also be excluded from this study

Keywords: diet west africa nutrition lmic
a multicenter phase ii/iii, placebo-controlled study of snx-111 administered intrathecally to cancer and aids patients with chronic pain

Conditions: HIV Infections; Cancer; Pain

Summary: to determine the safety and efficacy of snx-111 in controlling severe, chronic pain in cancer and aids patients.

patients are randomized to receive snx-111 or placebo (as per amendment 1/22/98: with randomization weighted 2:1 in favor of snx-111) via external pump and an intrathecal catheter (thin tube inserted into the spinal canal). (as per amendment 1/22/98: the dose is increased every 24 hours, in the absence of onset of analgesia or adverse events. after 2-5 days, patients who respond to their medication continue treatment at home for 5-8 days. patients who do not respond will be switched to the other regimen (i.e., placebo to snx-111, or snx-111 to placebo). after 10 days, responding patients are unblinded and asked to enroll in the long-term, open-label extension protocol. patients remain on a fixed dose at the therapeutic level found in the previous study. the dose may be increased or decreased at the discretion of the investigator. patients may continue therapy on a long-term basis until the drug is approved.

Eligibility criteria:
inclusion criteria concurrent medication: allowed: * rescue analgesia. patients must have: * chronic pain related to aids or cancer. * unsatisfactory response to prior opioid therapy. * life expectancy \> 3 months (or 1 month if an infusion pump is in place). exclusion criteria co-existing condition: patients with the following symptoms or conditions are excluded: * signs of sepsis or inadequately treated infection. patients with the following prior conditions are excluded: history of heart disease, heart failure, or asthma.

Keywords: acquired immunodeficiency syndrome aids-related complex pain palliative care omega-conopeptide mviia calcium channel blockers
infants colics : towards a migrainous origin ?

Conditions: Colic, Infantile; Migraine; Migraine Equivalents

Summary: according to recent studies, we want to find evidences that infant colics could be a episodic symptom associated to migraine as cyclic vomiting syndrome or abdominal migraine are. the main purpose is to compare the presence of colics in infants between 60 days and 180 days of life and the presence of migraine in their parents to determine if colicky children's parents are more migrainous than other parents.

recent studies shows that : * infants with colics have more probability to become migrainous when they will grow up * migrainous children have more colic history in their past * migrainous parents have more babies with colics than non-migrainous parents according to these studies, we want to find othen evidences that infant colics could be a migraine equivalent as cyclic vomiting syndrome or abdominal migraine are. recently, the international classification of headache disease iiibeta added in its appendix colics in the episodic symptoms associated to migraine the main purpose of our study in the pediatric emergency unit of nancy is to compare the presence of colics in infants and the presence of migraine in their parents to determine if colicky children's parents are more migrainous than other parents. the data collection will be made thanks to a survey which will be completed by the parents.

Eligibility criteria:
inclusion criteria: * all infants between 60 days and 180 days of life who comes to the nancy university hospital pediatric emergency unit exclusion criteria: * language barrier of parents

Keywords: colics infant colics migraine equivalent migraine episodic symptoms associated to migraine colic
mk0476 study in adult patients with perennial allergic rhinitis (0476-397)(completed)

Conditions: Rhinitis, Allergic

Summary: a clinical study evaluates the efficacy and safety of mk0476 in adult patients with perennial allergic rhinitis.


Eligibility criteria:
inclusion criteria: * adult patients with perennial allergic rhinitis exclusion criteria: * patients who have nasal diseases (e.g., nasal polyp, septonasal arcuation, hypertrophic rhinitis), upper respiratory infection, sinusitis, infectious rhinitis and those disease severe enough to interfere with assessment of effectiveness * patients who have rhinitis medicamentosa, or nonallergic rhinitis (e.g., vasomotor rhinitis, eosinophilia rhinitis) * patient has a disease of the cardiovascular, hepatic, renal, hematologic systems, or other severe disease
medical device for oxaliplatin-induced neuropathy in gastrointestinal cancer patients

Conditions: Peripheral Neuropathy Due to Chemotherapy

Summary: this is an observational study related to a medical device designed for the prevention of oxaliplatin-induced peripheral neuropathy (oipn) in patients with gastrointestinal cancer. the primary objective is to collect data through interviews with patients experiencing oipn symptoms to co-design the medical device prototype, incorporating the patient's perspective. additionally, the study aims to identify clinical and usability patterns that will help optimize the design of a future clinical investigation assessing the safety and efficacy of the final device.

main hypothesis: the clinical data collected from patient interviews, along with their active participation in the co-design of the localized cooling medical device, likely in the form of gloves, will enable the design of both the functional prototype and the future clinical research on safety and efficacy. this approach will increase the likelihood of patient acceptance of the medical device treatment and help identify different patient profiles that could benefit the most from it. secondary hypotheses: 1. patients will be able to easily adhere to the use of the device during chemotherapy. 2. the final glove design, in terms of materials and structure, will be suitable for commercial manufacturing and will have a viable demand among patients and healthcare providers. 3. there is no difference in treatment adherence between men and women or among people of different ages.

Eligibility criteria:
inclusion criteria: * outpatient patient with gastrointestinal cancer treated with oxaliplatin. * having completed at least three cycles of chemotherapy. * presenting acute or chronic symptoms of chemotherapy-induced peripheral neuropathy. * the study will include individuals over 18 years old. gender identify will be collected confidentially and inclusively, offering options for non-binary individuals and those who prefer not to identify with binary categories. exclusion criteria: * patient with osteoarthritis or arthritis in the hands. * diagnosis of any autoimmune disease affecting connective tissue, such as: rheumatoid arthritis, raynaud's syndrome, lupus, scleroderma, dermatomyositis, vasculitis, or cryoglobulinemia.

Keywords: peripheral neuropathy induced by oxaliplatin
cyanoacrylate tissue adhesives versus silk suture at the palatal donor site of sub epithelial connective tissue graft

Conditions: The Effect of Local Aplication of Cayanoacrylate Tissue Adhesives on Improving the Healing

Summary: subepithelial connective tissue grafts (ctg) are considered the gold standard procedure with proven clinical success when it comes to gingival augmentation aims to to improve periodontal health, which can enhance the long-term prognosis of teeth by obtaining soft tissue coverage of exposed root surfaces and/or augmentation the dimensions of gingival tissue. the procedure require harvesting tissue from a the palate, which increases the complexity of the procedure and patient discomfort. complications after harvesting a graft would be pain, inflammation, bleeding, flap necrosis and infection in the donor site.


Eligibility criteria:
inclusion criteria: * patients with mucogingival defects scheduled for sub epithelial connective tissue graft * age at least 18 years. * not having any systemic disease that could compromise wound healing * no periodontal surgery on the experimental sites. * no smoking, * no pregnancy or lactation exclusion criteria: * patients with coagulation disorders * patients on corticosteroids, with uncontrolled diabetes, or with any systemic disease that precluded periodontal surgery * patients with a history of contact dermatitis to formaldehyde * loss of maxillary premolars and molars * medications or antibiotics used in the previous 6 months * pregnancy or lactation * smoking
instrument assisted soft tissue mobilization versus trigger points release on upper trapezius trigger points

Conditions: Trigger Points

Summary: study will be randomized clinical trial. data will be collected from non probability consecutive sampling technique. total 30 participants from ganga ram hospital and care medical centre will be selected and randomly allocated to two different groups i.e group a and group b. . group a will be treated by trigger point release. group b will be treated by instrument assisted soft tissue release. nprs, goniometry, ndi will be used as outcome measuring tool before and after treatment. data will be analyzed by using statistical package for social sciences 25.

trigger point is defined as a hyperirritable palpable nodule contained in the skeletal muscle fibers. the palpable nodule, also named taut band, is described as a limited number of fibers with an increased stiffness. trp causes the muscles to week and stiff, leading to reduction in range of movement. mtrp can produce local and referred pain, either on manual compression or spontaneously. instrument-assisted soft tissue mobilization (iastm) is the use of hard tools to manipulate soft tissue and was derived from the cyriax1 cross-friction massage. it has recently emerged as a popular alternative to traditional manual therapy techniques. modern-day iastm instruments vary in material (e.g. stainless steel, plastic) and design and are used to improve a variety of musculoskeletal conditions and associated outcomes. manual technique that uses direct vertical pressure to the tp, is a well-established treatment method used to resolve the tp-related pain syndrome. this directed pressure is managed according to the therapist's perception of the tissue resistance of the treated soft tissue or according to the pain perceived by the patient based on a pain scale. manual therapy is a commonly used treatment for mps as it has been considered one of the most effective techniques for the inactivation of mtrps.

Eligibility criteria:
inclusion criteria: * patients with neck pain in the upper trapezius muscle * tender nodule, constant pain, a jump sign during palpation will be included in this study exclusion criteria: * patients with whiplash injury * history of neck/shoulder surgery * cervical radiculopathy * history of malignancy

Keywords: upper trapezius pain
epiretinal macular membrane and cataract extraction

Conditions: Epiretinal Macular Membrane; Cataract Extraction

Summary: the investigators proposed to assess the functional and anatomical outcomes of cataract and idiopathic epiretinal macular membrane extraction in combined and consecutive surgeries.

a retrospective nonrandomized clinical case series study collected 174 consecutive eyes of 174 patients undergoing macular surgery between january 2005 and december 2006. patients suffering from epiretinal macular membranes (erm) secondary to uveitis, trauma, or associated with a simultaneous retinal detachment (rd) were excluded. we treated 109 eyes with a combined procedure (group 1) and 65 eyes with a consecutive surgery (membrane surgery and cataract separately)(group 2).

Eligibility criteria:
inclusion criteria: * all patients had symptomatic visual loss and needed vitrectomy for erm removal. exclusion criteria: * patients suffering from erm secondary to uveitis, trauma, or associated with a simultaneous rd were excluded.
the identification of novel prognostic markers in melanoma

Conditions: Malignant Melanoma

Summary: the purpose of this project is to analyze tumour tissue from a group of subjects with malignant melanoma, who have been treated at the royal marsden hospital.

background - the royal marsden hospital and the institute of cancer research constitute the largest comprehensive cancer centre in europe. in addition to an in-house drug development program, phase i - phase iii clinical trials of novel anti-cancer agents are hosted. in order to investigate the optimal use of novel molecularly targeted agents, access to clinical tumour samples is needed in order to determine which particular cancer type expresses a molecular "signature" that may indicate potential therapeutic utility. understanding such signatures should accelerate the registration of new drugs for routine cancer therapy; offering the potential of selecting those patients with tumour types most likely to benefit from therapy. furthermore, new insights into disease biology may be gained. main research question/ objective - are there features of primary melanoma or lymph node metastases that predict subsequent clinical outcome better than existing markers?

Eligibility criteria:
inclusion criteria: * diagnosis of melanoma * adequate paraffin-embedded material available for analysis. * adequate clinical follow-up information * written informed consent where applicable exclusion criteria: * inadequate paraffin-embedded material available * inadequate clinical follow-up information.

Keywords: melanoma novel prognostic markers
clinical algorithm for post-stroke gait training with c-brace

Conditions: Hemiparesis Due to Stroke; Hemiplegia Due to Stroke

Summary: the purpose of this study is to develop a clinical algorithmic-based evaluation and treatment approach for c-brace for use by persons with hemiparesis or hemiplegia due to stroke.


Eligibility criteria:
inclusion criteria: * age 18 - 65 years * diagnosis of hemiparesis or hemiplegia following stroke * presence of abnormal walking pattern * poor knee control during stance phase * cognitive ability to (or care provider) manage daily charging of battery * cognitive ability to follow commands * hip flexor muscle strength grade 3 or greater or the ability to perform reciprocal gait using compensatory patterns exclusion criteria: * weight \> 275 lbs. (includes body weight and weight of heaviest object carried) * less than 2° of ankle motion * severe spasticity of the quadriceps (mas \>3) and/or uncontrolled spasticity of the quadriceps * severe spasticity of other lower limb muscles (mas \>3) * fixed genuvalgum exceeding 10° beyond anatomic neutral valgum * any fixed genuvarum exceeding anatomic neutral varum. * hip or knee flexion contractures greater than 10° * presence of chronic obstructive pulmonary disease (copd) * chronic heart failure - new york heart association (nyha) stages 3 and 4
massive mental health screening using smartphones in 24 pre-graduate education centers in mexico city: teduca survey protocol

Conditions: Suicidal Ideation; Social Behavior; Depression; Depressive Disorder; Anxiety; Alcohol Drinking; Drug Abuse

Summary: the objective of this study is to make a massive suicide risk and social behavior assessment in 24 pre-graduate education centers in mexico city (approximately 30,000 students aged between 15 and 22 years), taking also into account other outcomes such as depression, anxiety, alcohol and drugs. for this, an app for smartphone (memind) or a web platform (www.memind.net) will be used in which the participants will take a self-administered questionnaire, composed of several psychometric instruments. our main hypothesis is that identification of suicide risk in the mexico city's student community is feasible using their own smartphones and can serve as both a population screening tool for early specialist referral, as well as a tool for evaluating social behavior strategies and their relation to suicide behavior.


Eligibility criteria:
inclusion criteria: 1. use a smartphone as personal or computer terminals enabled by the municipality of milpa alta or educational services. 2. be able to understand the nature, purpose and methodology of the study. 3. accept participation in the study and check the corresponding box in the app to verify that the informed consent has been expressly given. exclusion criteria: 1. subject deprived of liberty (by judicial or administrative decision) 2. subject protected by law (guardianship or conservatorship)

Keywords: mass screening health surveys mental health suicidal ideation young adult interpersonal relations smartphone
endoscopic myotomy of the lower esophageal sphincter for achalasia

Conditions: Achalasia

Summary: this is a study of the safety and efficacy of a new surgical procedure using endoscopic instruments and a tunneling technique to reach the les for dissection. we hypothesize that this technique provides an incisionless, less invasive option with similar functional outcome compared to standard heller myotomy.

by the endoscopic creation of an esophageal submucosal tunnel the inner circular muscle layer can be easily visualized. in contrast to conventional heller myotomy, the dissection of only the inner circular esophageal muscle layer leaves the outer longitudinal muscle layer intact. thereby, post-interventional reflux disease should be avoided.

Eligibility criteria:
inclusion criteria: * ability to undergo general anesthesia * age \> 18 yrs. of age and \< 85 yrs. of age * ability to give informed consent * candidate for elective heller myotomy exclusion criteria: * previous mediastinal or esophageal surgery * contraindications for esophagogastroduodenoscopy * bmi \> 45

Keywords: achalasia
the effects of acupressure on pain, and gastrointestinal functions in women with hysterectomy

Conditions: Pain Management; Hysterectomy; Vomiting

Summary: aim this randomized controlled trial was conducted to evaluate the effect of acupressure application on gastrointestinal functions and pain after abdominal hysterectomy. materials and methods after undergoing hysterectomy, 39 women were randomised into acupressure (n=19), and control groups (n=20). women in the acupressure group received acupressure on the mide meridian (st36), the heart meridian (ht7), large intestine meridian (li4), intersection of the spleen, liver and kidney meridians 6(sp6) and pericardium meridian (pc6) acupoints 30 min after admission to the clinic, for a period of 15 min, whereas those in the sham group received acupressure on locations 1-1.5 cm away from these points. the control group received standard treatment. the patient information form, visual analog scale, the rhodes index of nausea, vomiting and retching, and daily follow-up form were used for data collection.

the study consists of two groups: control and experimental groups. those who received acupressure application were called the experimental group, and patients who received routine post-operative care were called the control group. acupressure application was applied to the experimental group at the third and twenty-fourth hours after surgery. the control group was evaluated without any application for two days. for the acupressure application, planning was made to adjust the temperature, light, and silence of the environment and to pay attention to privacy. 5 points that positively affect gastrointestinal functions and pain were selected (sp6, st36, pc6, ht7, li4). the duration of the session was determined to be approximately 18-20 minutes, depending on the preparation and pressure time to be applied on the 5 selected points (a total of 10 points were applied since each point will also be applied to its counterpart in the other extremity). acupressure application was applied to each point for 1.5 minutes (1.5\*10=15 minutes). the application was applied to a total of 39 women, 19 experimental and 20 control. no treatment was performed on the women in the control group other than routine post-operative care.

Eligibility criteria:
inclusion criteria: * women with post hysterectomy operation * turkish women over the age of 18 years * had no wounds or ulcerations in the areas where acupressure would be applied on the arms' legs * had no intestinal obstruction, irritable bowel syndrome, inflammatory bowel disease, or abdominal herniation due to bowel cancer * had defecated at least three times a week in the last trimester * had stools of normal consistency; did not develop any serious postoperative complications exclusion criteria: * had chronicle constipation, fecal incontinence or diarrhea * who used laxatives, suppositories oath enemas, * who were immobilized, * who did not agree to participate in the study, * who did not speak turkish.