Kornimate/medical-research-clean huggingface dataset:
cerebral oxygenation to guide supplemental oxygen

Conditions: Oxygen Saturation

Summary: objective: objective of this pilot feasibility study is to monitor crso2 using nirs invos 5100 (somanetics, usa) in addition to spo2 monitoring to guide supplemental oxygen delivery and respiratory support based on both measurements in preterm neonates during the first 15 minutes after birth. patients: preterm neonates \<34+0 weeks of gestation born via caesarean section and/or who require respiratory support will be eligible for the study. design: a prospective two-centre randomized controlled pilot feasibility study methods: study group: pulse oximetry will be used to measure spo2 and heart rate as routine non-invasive monitoring in the first minutes of resuscitation. in addition during the first 15 minutes nirs measurements will be recorded. crso2 measurements in addition spo2 measurements will be used to guide supplemental oxygen support and respiratory support during the first 15 minutes after birth. control group: only spo2 measurements will be used to guide supplemental oxygen support and respiratory support during the first 15 minutes after birth. hypothesis: supplemental oxygen support and respiratory support guided by crso2 and spo2 measurements will reduce the time in % minutes of crso2 \ 90th centile in preterm neonates during the first 15 minutes after birth outcome parameter: primary outcome parameter will be duration in % minute of crso2 \ 90th centile.


Eligibility criteria:
inclusion criteria: * preterm neonate \<34+0 weeks after caesarean section * decision to conduct full life support * written informed consent exclusion criteria: * no decision to conduct full life support * no written informed consent * congenital malformation
orthotics and parkinson's disease: the acute and long-term effects of increased somatosensory feedback

Conditions: Parkinson Disease

Summary: the purpose of this study is to increase clinical knowledge of the relationship between increased plantar sensory information and orthotics in a parkinsonian gait. the objectives of this study are to determine if orthotics, with and without a textured top cover, can alter muscle activation, gait parameters, balance, functional mobility, and decrease fall risks in parkinson's participants.

the purpose of this study is to increase clinical knowledge of the relationship between increased plantar sensory information and orthotics in a parkinsonian gait. observing gait parameters and muscle activation changes, in orthotics with and without a textured top cover, provides an increased understanding of conservative treatment options available to the parkinson's population. it is hypothesized that balance and functional mobility in parkinson's disease (pd) patients will increase, while decreasing fall risks, when wearing both types of orthotics. larger improvements are expected with the orthotics with a textured top cover, thus increasing plantar sensory feedback. male and female participants, aged 55-75, with a diagnosis of idiopathic parkinson's disease can participate in the study. two types of orthotic design will be examined: 1) customizable over-the-counter orthotics and 2) customizable over-the-counter orthotics with a textured top cover. five different assessments will be performed during three different testing sessions: 1) baseline testing; 2) 6-weeks post-baseline; and 3) 12-weeks post-baseline. the administered assessments include: 1) static balance, double limb stance; 2) the berg balance scale (bbs); 3) timed up and go (tug), 4) functional gait assessment (fga); and 5) walking task.

Eligibility criteria:
inclusion criteria: * diagnosed with idiopathic parkinson' disease exclusion criteria: a pre-screening questionnaire will assess the following: * peripheral neuropathy, vestibular concerns, cognitive impairment, severe arthritic conditions, or other conflicting medical conditions * deep brain stimulation * currently wearing orthotics, or previously worn in the last two years * decreased plantar sole sensation * requires the ability to walk 10m unassisted

Keywords: postural balance gait foot orthotic proprioception somatosensory
neuromuscular electrical stimulation in critically ill patients.

Conditions: Critical Care; Rehabilitation

Summary: the study will investigate the effects of neuromuscular electrical stimulation (nmes) in critically ill patients. the objective of this study will be investigate the effects of neuromuscular electrical stimulation (nmes) in critically ill patients.

the study will investigate the effects of neuromuscular electrical stimulation (nmes) in critically ill patients. it will be a randomised crossover clinical trial. thirty-one patients will enrolled. patients will be selected, randomly, to the intervention protocol (decubitus position with the limbs raised and nmes) and control (decubitus position with the limbs raised without nmes).the patients will be allocated in group 1 (intervention and control) or group 2 (control and intervention) with a wash-out period of 4 to 6 hours between them. the main outcome will be metabolic data. linear mixed model will be used for analysis of dependent variables and estimated values of the mean of the differences of each effect. the results of this study will allow better understanding of the metabolic effects of nmes in patients critically ill.

Eligibility criteria:
inclusion criteria: * all patients that will be admitted to the intensive care unit * hemodynamic stability * mechanical ventilation. exclusion criteria: 1. in general: * a. pregnant women * b. brain death * c. neuromuscular diseases * d. use of pre-existing neuromuscular blocker in the last 24 hours, prior to the study protocol. 2. contraindications for the use of nmes: * a. fractures * b. burns * c. skin lesions * d. systemic vascular impairment diseases such as systemic lupus erythematosus, thromboembolic disease, deep vein thrombosis (which was not therapeutically anticoagulated for a time greater than 36 hours) * e. lower limb amputations * f. cardiac pacemaker, * g. thrombocytopenia less than 20,000/mm3 * h. bmi greater than 35 kg/m2 * i. important lower extremity oedema * j. agitation and/or signs of pain during the electrical stimulation. 3. contraindications to begin or continue nmes procedure: * a. mean arterial blood pressure less than 65 mmhg * b. use of vasopressor \>50% of themaximum dose (dopamine \>12.5 μg/kg per minute; vasopressin \>0.02u/min and norepinephrine \>1 μg/kg per minute), * c. heart rate \ 140bpm * d. arrhythmias with hemodynamic consequences * e. myocardial ischemia, * f. temperature \ 39oc * g. intracranial pressure \>20 cmh2o * h. decrease in 10% of spo2 baseline value or \<88% for more than one minute.

Keywords: physical therapy modalities, electric stimulation therapy indirect calorimetry
consistency between measures of renal function in icu patients

Conditions: Critical Illness

Summary: this study aim to compare different measures of renal function (glomerular filtration rate) in icu patients.

the study uses a large dataset of prospectively collected data according to clinical routines.

Eligibility criteria:
inclusion criteria: * icu patients with at least one measurement of urinary creatinine clearance exclusion criteria: * renal replacement therapy initiated before the measurement of creatinine clerance
prospective prom and prem analysis demonstrating specification advantage and language barriers

Conditions: Head and Neck Cancer

Summary: importance: patient reported outcome and experience measures (prom and prem) constitute a cornerstone of the collective efforts to improve and personalize healthcare systems. the eortc quality of life (qol) group developed instruments evaluating general and disease specific oncology qol questionnaires, and the quality of information received. implementation of prem and relevant prom is essential for equity, better resources utility, accessibility and patient centered treatment. objectives: the investigators describe the eortc info 25 translation process followed by investigation of subpopulation where action is most needed. the investigators investigate which qol questionnaire better reflects clinical parameters among head and neck cancer (hnc) patients. design: a prospective cohort. setting tertiary, referral, head and neck dedicated surgical service. participants: consecutive head and neck cancer adult patients, surgically treated, recruited between january to december 2022. exposures: the investigators prospectively analyzed the new eortc info 25 hebrew questionnaire together with previously established arabic translated version and the general (qlq-c30) and specific (qlq - h\&n43) oncology qol questionnaires. main outcomes and measures: analyzing the quality of information provided and desired in diverse hnc subgroup of patients. analyzing which of prom questionnaire better reflects hnc patients' disease and treatment parameters, which in turn, may predict poorer qol. results: the investigators recruited 60 patients, consisting of equal female: male ratio, of which 16.66% were native arabic speaking. validated info 25 scores (median 62.6±17.5) were not associated with patients' age, sex, education status, disease, and treatment parameters. yet, the arabic spoken sub-population had significantly lower scores (p\<0.001). in contrast to qlq-c30, clinical imperative associations were demonstrated between qlq - h\&n43 and patients' disease stage (p\<0.001), admission days (p\<0.0001), free flap reconstruction (p\<0.001) and adjuvant radiotherapy (p\<0.001). conclusions and relevance: the final version of the native eortc info25 translation was approved by the eortc. the investigators demonstrate lower info25 scores among the arabic speaking population, suggesting frail equity and accessibility. in order to improve patients' centered treatment and resource utilization, the investigators reveal a strong association between disease severity and treatment aggressiveness and poor quality of life on specific, hnc oriented, eortc qlq - h\&n43 questionnaire that was not validated on eortc qlq-c30, which can be omitted.


Eligibility criteria:
main inclusion criteria: * adult patients (≥18 years) * head and neck cancer patients surgically treated main exclusion criteria: \* illiterate
prevalence of periodontitis in patients with plaque psoriasis. a cross-sectional study

Conditions: Psoriasis; Plaque Psoriasis; Periodontal Diseases; Periodontitis

Summary: psoriasis is a chronic inflammatory disease with a multi-factorial etiology which affects the epidermis and dermis. it affects around 1-3% of the general population and its most frequent form is plaque psoriasis (around 80-90% of the overall psoriasis cases). psoriasis severity and extension are usually measured through 2 scores: psoriasis area severity index (pasi) and body surface area (bsa). periodontitis is a chronic inflammatory disease mediated by the biofilm and with a multi-factorial etiology. its manifestation entails the destruction of the periodontal tissues surrounding the teeth; the final stage of disease is characterised by tooth loss. periodontitis severity and extension are usually evaluated through surrogate variables such as: bop (bleeding on probing), ppd (probing pocket depth) e rec (recession). both diseases present overlapping genetic and pathophysiologic features, as well as common risk factors (e.g. genetic polymorphisms, smoking habit, obesity, diabetes etc.). mirnas are small non-coding molecules involved in the regulation of various biologic processes thanks to their interaction with mrnas. active inflammatory processes either in the oral cavity or at a systemic level tend to alter the concentration of salivary mirnas. no study so far has ever profiled the levels of specific salivary mirnas in patients with psoriasis and periodontitis. some case-control studies highlighted a higher prevalence of periodontitis in patients with psoriasis when compared to healthy controls. nonetheless, epidemiological data regarding periodontitis prevalence in patients with psoriasis are lacking; moreover, few data are available regarding the relationship between the severity of psoriasis and the severity of periodontitis, together with the effect of common risk factors (e.g. diet, obesity, physical activity, sleep quality etc.).


Eligibility criteria:
inclusion criteria: * age between 18 and 70 years old * diagnosis of plaque psoriasis * ability and willingness to give informed consent exclusion criteria: * inability of unwillingness to give informed consent * pregnancy or lactation
repetitive transcranial magnetic stimulation associated with manual therapy in knee ostearthritis pain

Conditions: Knee Osteoarthritis

Summary: in this study, the investigators wondered whether the association between high frequency repetitive transcranial magnetic stimulation (hf-rtms) and manual therapy (peripheral and central approach) is more effective in reducing pain levels and modulation of cortical activity of chronic knee ostearthritis pain subjects than manual therapy alone (usual peripheral approach). for this purpose, patients included will be submitted to one session with active or sham hf-rtms followed by a protocol of manual therapy. besides that another active group will have the sequence of interventions exchanged (manual therapy followed by hf-rtms) in order to investigate whether this may influence in the final outcomes.


Eligibility criteria:
inclusion criteria: * diagnosis of knee oa; * absence of severe cognitive deficiency verified by the mini mental state examination; * meet the american college of rheumatology criteria for idiopathic knee osteoarthritis. exclusion criteria: * individuals diagnosed with osteoporosis, fibromyalgia or other neurological disease; * had an opioid or corticosteroid injection in the last 30 days; * modified chronic pain medication in the last month before participating in the study; * history of knee surgery in the last six months; * obese; * contraindications to the use of non-invasive brain stimulation, such as: metal implant on face or skull, history of seizure, cochlear implant.

Keywords: knee ostearthritis transcranial magnetic stimulation repetitive transcranial magnetic stimulation chronic pain musculoskeletal manipulations
improving patient-centered care delivery among patients with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study involves development and testing of a patient and family-centered transitional care program for patients who are hospitalized with chronic obstructive pulmonary disease (copd) exacerbations. the study intervention includes tailored services to address individual patients' biopsychosocial needs, starting early during hospital stay and continuing for 3 months post hospital discharge. the study hypothesis is that compared to usual care, the study intervention will : a) improve patient health- related quality of life and survival, and reduce use of hospital and emergency room visits; b) result in improved patient experience, self- confidence, and self-care behaviors; c) result in improved family caregivers coping skills, self-confidence, and problem solving skills to address patient barriers to care and treatment.

this study evaluates using a randomized controlled trial design the impact of a patient and family-centered transitional care program named the breathe program. the breathe program stands for 'better respiratory education and treatment help empower'. the breathe program offers the following: 1. individualized transition support services to help ensure that the patient (and family caregiver if available) are prepared for discharge, understand the discharge plan of care, and receive post discharge follow up to help meet their needs 2. tailored copd self-management education and support program that starts during the hospital stay and continues post discharge in the community setting 3. facilitated access to community based services. the intervention is delivered by a new team member called "copd nurse transition guide". the new team member works with both the hospital and outpatient care teams, is a registered nurse with homecare services experience, and have received additional training in copd self-management and motivational interviewing. the nurse meets participants in the hospital and then follows up with them via home visits and phone calls.the intervention involves both patients and family caregivers (if available), is literacy adapted, and follows a tailored approach based on patient needs, priorities, and preferences.

Eligibility criteria:
inclusion criteria: * admitted to the hospital with a diagnosis of an acute copd exacerbation; or has a previous copd diagnosis\* and receiving treatment to control copd symptoms - (e.g. nebulizer treatment, prednisone course, ...) in the current hospitalization * age \> 40 and \>10 pack-yrs smoking * english speaking * anticipated discharge back to home (rather than to hospice or long term nursing home placement) exclusion criteria: * severe cognitive dysfunction * terminal illness (less than 6 months life expectancy) that is non-copd related * homeless (no home address)

Keywords: patient self-care behaviors patient activation family caregiver support patient-centered care
results in real clinical practice of treatment of moderate-severe atopic dermatitis

Conditions: Dermatitis, Atopic

Summary: the purpose of this study is to determine the efficacy results in terms of percentage improvement of the eczema area and severity index (easi) as well as on the scale patient global assessment (pga) throughout the follow-up of patients undergoing subjected to systemic and/or biological treatments in conditions of usual clinical practice. likewise, collect safety data, recording adverse events related to medication.

this is an observacional follow-up study, open-label (all people know the identity of the intervention), prospective (study following participants forward in time), multi-center study in adult participants with moderate to severe atopic dermatitis. a registration can also be made retrospective data from the patient's medical history. participants will be treated with one of this therapy (phototherapy, cyclosporine, methotrexate, azathioprine, mycophenolate, dupilumab, baricitinib, upadacitinib or tralokilumab). a series of variables will be measured (basal surface area affected (bsa), eczema area and severity index (easi), numbers of shoots, analytical determinations and current treatment and adverse effects occurred) in order to observe the changes in the improvement of the disease. questionnaires will also be carried out to analyze whether the drug acts favorably in improving the disease. questionnaires like dermatology life quality index (dlqi), patient global assesment (pga) and patient oriented scoring atopic dermatitis (po-scorad).

Eligibility criteria:
inclusion criteria: * over 18 years. * patients treated with any systemic therapy (other than topical therapy) according to criteria clinical and routine clinical practice. therefore, the treatments included will be: phototherapy, cyclosporine, methotrexate, azathioprine, mycophenolate, dupilumab, baricitinib, upadacitinib and tralokilumab. * patients who grant informed consent. exclusion criteria: * patients who do not have the necessary comprehension capacity to understand and sign the informed consent. * patients who, according to routine clinical practice, require only topical treatment.
the effect of low-level laser therapy as an adjunct to non-surgical therapy in different age groups

Conditions: Periodontal Inflammation

Summary: the summary is to evaluate the effect of low-level laser therapy as an adjunct to non-surgical therapy on inducible nitrous oxide synthase salivary levels in different age groups of chronic periodontitis patients

2 ml of unstimulated saliva will be collected using spitting method, the collected samples will then be analyzed using elisa technique for salivary inducible nitrous oxide synthase levels.

Eligibility criteria:
inclusion criteria: * males and females * aged below 40 or above 60 * periodontitis stage 2 * no tooth loss due to periodontitis exclusion criteria: * smoking habits * history of antibiotics * history of systemic diseases
tranexamic acid in pediatric cardiac surgery

Conditions: Blood Loss; Congenital Heart Disease

Summary: tranexamic acid(txa) is an antifibrinolytic agent to reduce blood loss in cardiac surgery. previous seven rcts comparing effects of txa in pediatric cardiac surgery showed conflict results. the reason why they showed mixed results would be the imbalance of patients population with regard to presence of cyanosis. txa would reduce blood loss in pediatric cardiac surgery with well balanced patients population.


Eligibility criteria:
inclusion criteria: * children undergoing elective cardiac surgery with cardiopulmonary bypass exclusion criteria: * neonate born within 1 month * preoperative inotropes * preoperative mechanical ventilation * preexisting coagulation disorder * reoperation within 48 hours * significant liver or kidney disease * known allergy to txa

Keywords: pediatric cardiac surgery bleeding tranexamic acid fibrinolysis blood loss in pediatric cardiac surgery
early arthroscopic partial meniscectomy(apm)

Conditions: Meniscus Tear

Summary: arthroscopic partial meniscectomy(apm) surgery outcomes for metabolic syndrome(mets) patients with degenerative meniscus tears(dmts) was still not clear. the aim of the study was to investigate outcomes of early apm vs delayed apm for mets patients with degenerate meniscus tears.

degenerate meniscus tears(dmts) were the most common knee disease in aged and obese people. the most common treatment for dmts was arthroscopic partial meniscectomy(apm) surgery. however, the time window for performing apm surgery was unclear, especially in obese patients with metabolic syndrome(mets). abdominal obesity, insulin resistance with or without glucose intolerance, dyslipidemia or elevated blood pressure are included in the principal components of mets. whether early apm within 3 to 6 months or delayed apm surgery within 6 to 12 months are benefical to mets patients with dmts. the knee function outcomes between early apm and delayed apm for mets patients with dmts were assessed and follow up to 12 months after surgery.

Eligibility criteria:
inclusion criteria: * • must be age between 35 and 70 years old; * clinical diagnosis of metabolic syndrome; * clinical diagnosis of degnerate meniscus tears; exclusion criteria: * must be able to have no acute knee injury such as car crash or acute sports injury; * must be able to have no knee surgeries history; * must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity; * must be able to have no contraindications to mri; * must be able to have no severe cardiopulmonary disease; * must be able to have no musculoskeletal or neuromuscular impairments ; * must be able to have good visual, hearing, or cognitive;
vitamin d metabolites as biomarkers for the identification of kidney injury in cardiac surgery

Conditions: Acute Kidney Injuries; Chronic Renal Diseases

Summary: we will be measuring vitamin d metabolites in blood samples drawn from patients undergoing cardiac surgery to determine the correlation with renal function as assessed by serum creatinine. we will include 20 patients in each of the following 3 groups based on serum creatinine measured within 28-days of surgery: 1) normal kidney function (egfr \> 60 ml/min, n=20), 2) moderate impaired kidney function, egfr between 30 and 60 ml/min (n=20) and 3) severe kidney dysfunction egfr \< 30 ml/min (n=20).


Eligibility criteria:
inclusion criteria * ≥ 18 years * patients undergoing cardiac surgery * serum creatinine measured with 28 days of surgery exclusion criteria * exogeneous calcitriol (1,25(oh)2d3) intake * history of parathyroidectomy * patients with liver or kidney cancer * patients with liver disease (e.g. liver failure, cirrhosis)

Keywords: chronic renal disease, acute kidney injury, vitamin d