taurine supplementation and exercise on irisin levels in obesity

Conditions: Obesity

Summary: irisin is a myocin secreted by skeletal muscle in stimulus to physical exercise and has been described as a possible therapeutic tool in the fight against obesity by triggering a cascade of signaling that triggers the expression of genes responsible for the increase in energy expenditure and browning of adipose tissue white cells by activating thermogenesis promoter mitochondrial proteins. although the science is engaged in the search for evidences about the actions of the irisin, the physical exercise involved and the improvement in the levels of obesity, many mechanisms are still unknown. since taurine by means of irisin-like pathways also increases energy expenditure, it is believed that taurine supplementation associated with high intensity aerobic physical exercise can optimize the effects of irisin, increasing energy expenditure and improving body composition in obesity.

introduction: irisin is a myocin secreted by skeletal muscle when stimulated by physical exercise that promotes increased thermogenesis (browning effect). similarly, taurine is also associated with modulations of energy metabolism with promising actions in the control of metabolic disorders. thus, it is believed that chronic taurine supplementation associated with physical training can optimize irisin concentrations after exercise. objective: evaluate the effects of taurine supplementation associated with interval aerobic training on plasma irisin concentrations, energy expenditure, body composition and physical fitness in obese women. methods: twenty-two women aged 25 to 45 years, sedentary, with grade i obesity (bmi ≥30-35 kg / m²) and without comorbidities will be recruited for the study. the subjects will be submited to a high intensity interval aerobic training for 8 weeks, being 3 times by week, for 50 minutes, associated to the supplementation with 3g of taurine or placebo. methods: assessment of dietary intake, resting energy expenditure (ger) by indirect calorimetry, body composition by deuterium oxide, anthropometric measurements, hplc plasma analysis of taurine, multiplex irisin and physical fitness variables will be performed pre and post intervention. the results will be expressed as mean and standard deviation and the anova test two way repeated measures mixed model will be applied, with post hoc sidak, to verify differences and statistical interactions (p \<0.05).

Eligibility criteria:
inclusion criteria: * this study included women with obesity grade i (bmi ≥30 - ≤35kg/m²), sedentary, with no associated comorbidity, convenience sample. exclusion criteria: * women classified as overweight, obesity grade ii and grade iii (morbid), who present comorbidities associated with obesity (pre-diabetes, diabetes, hypertension, dyslipidemia, cardiovascular diseases and diseases of bone metabolism); smokers; who use hormones, sports supplements and / or weight loss medications. perform some type of nutritional monitoring followed by diet or weight loss guidelines and that have medical impediment to the practice of physical exercise.

Keywords: obesity exercise irisin taurine energy expenditure