Kornimate/medical-research-clean huggingface dataset:
home based tele-exercise for people with chronic neurological impairments

Conditions: Neurologic Disorder; Stroke; Spinal Cord Injuries; Cerebral Palsy; Hemiplegia; Hemiparesis; Multiple Sclerosis; Parkinson Disease; Trauma, Brain; Transverse Myelitis; Friedreich Ataxia

Summary: to assess the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (cni).

this study aims to examine how effective seated zoom exercise classes are for a person with cni for addressing cardiovascular health, physical wellness and quality of life. if these classes prove to be effective, online platforms could be a viable avenue for those with cni to exercise and increase/maintain wellness without having to leave their homes. the investigators are also attempting to determine if a class with a live instructor vs a pre-recorded class has an effect on motivation, compliance, exertion and modifications/safety. the entire process, including screening and consenting, will be done via zoom and redcap, potentially providing a blueprint for the future studies. this process can enable participants to participate in studies with minimal inconvenience, expense and effort of traveling for the consent process.

Eligibility criteria:
inclusion criteria: 1. participants with chronic (\>6 months) neurological impairments 2. 18 to 75 years of age 3. participants who can provide a medical clearance to participate in the program 4. participants who can remain seated for at least one hour 5. heart rate/bp considerations, per each participant's md 6. participants must be able to don/doff hr monitor without assistance, or have assistance if necessary 7. participants must maintain their current exercise/physical activity routine during the course of the study 8. clinically stable with no other neurological, medical or cognitive impairments 9. reliable internet connection and ability to use zoom platform 10. participants must speak and understand english 11. no contraindication/limitations to exercise 12. currently exercising 2 days or less per week exclusion criteria: 1. participants with any cognitive impairment preventing safe and accurate participation in the program 2. medical issues preventing safe participation 3. other problems possibly contraindicating autonomous exercise at home if no supervision available.
early identification of sepsis in children

Conditions: Sepsis; Shock, Septic; Sepsis, Severe; SIRS

Summary: this observational nation-wide study is focused on evaluation of the new possible biomarkers for pediatric sepsis and their specificity/sensitivity in combination with usual diagnostic markers for sepsis in the terms of early identification of sepsis, severe sepsis, and septic shock.

the understanding of sepsis pathophysiology underwent a great progress during the last decades and the therapy of sepsis is in the focus of the research for many years, but sepsis is still one of the main causes of death in the icus around the world. systemic inflammatory response syndrome (sirs) is closely connected with the sepsis development, but sirs also represents a high risk of organ dysfunction in non-infectious patients (trauma, stress, cardiopulmonary arrest). early diagnosis and prevention of the organ dysfunction are the mainstay of the correct and timely therapy, but currently there is no reliable, quick and simple method for the diagnosis of sepsis. and also there is no generally accepted clinical or laboratory parameter, which can be used to differentiate between sepsis and sirs. there are some commonly available biomarkers that showed promising results in critically ill adult patients. those include immature platelet fraction (ipf), immature granulocytes (ig) count and nucleated red blood cells (nrbc) count. the knowledge of their variability in different phases of illness (sirs/sepsis/severe sepsis/septic shock) in pediatric patients is very limited, as is their connection with other generally used markers of infection (crp, procalcitonin, presepsin). this study is strictly non-interventional and focused on usability of above mentioned biomarkers in the early diagnosis of sepsis/sirs and on the reduction of morbidity/mortality of pediatric intensive care unit (picu) patients with sepsis/sirs. in all patients admitted to picu in selected study period, the inflammation markers - c-reactive protein (crp), procalcitonin (pct), presepsin (soluble cluster of differentiation 14-subtypes) and full blood count parameters -ipf,ig,nrbc will be measured at the time of admission and on 3rd, 5th and 7th day of stay in intensive care. the organ dysfunction score will be evaluated daily.

Eligibility criteria:
inclusion criteria: * all patients admitted to picu until the 18th year of age * expected length of stay \> 48 hours exclusion criteria: * oncology patients * immunosuppressive therapy * immunostimulant therapy * autoimmune disease * post-organ transplant patient * thrombocytopaenia, thrombocytopathy

Keywords: sepsis septic shock severe sepsis sirs children immature platelet fraction (ipf) immature granulocytes (ig) nucleated red blood cells (nrbc)
relative bioavailability study of 4 different formulations of pf-07321332 relative to the commercial tablet formulation

Conditions: Bioavailability

Summary: the purpose of this study is to estimate the relative bioavailability of pf-07321332 in different formulations in healthy adult participants.


Eligibility criteria:
inclusion criteria: * participants who are overtly healthy as determined by medical evaluation including medical history, physical examination (pe), laboratory tests, vital signs and standard 12 lead ecgs. * body mass index (bmi) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lb). * participants who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures exclusion criteria: * positive test result for sars-cov-2 infection at the time of screening or day -1. * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing). * clinically relevant abnormalities requiring treatment (eg, acute myocardial infarction, unstable ischemic conditions, evidence of ventricular dysfunction, serious tachy or brady arrhythmias) or indicating serious underlying heart disease (eg, prolonged pr interval, cardiomyopathy, heart failure greater than new york heart association (nyha) 1, underlying structural heart disease, wolff parkinson-white syndrome). * any condition possibly affecting drug absorption (eg, gastrectomy, cholecystectomy). * history of human immunodeficiency virus (hiv) infection, hepatitis b, or hepatitis c; positive testing for hiv, hepatitis b surface antigen (hbsag), or hepatitis b surface antibody (hcvab). hepatitis b vaccination is allowed. * use of prescription or nonprescription drugs and dietary and herbal supplements within 7 days or 5 half lives (whichever is longer) prior to the first dose of study intervention. * participant who have received a covid-19 vaccine within 7 days before screening or admission, or who are to be vaccinated with a covid-19 vaccine at any time during the study confinement period. * a positive urine drug test.

Keywords: coronavirus disease 2019 (covid-19) severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
aortic calcification and central blood pressure in patients with chronic kidney disease

Conditions: Arterial Calcification; Kidney Diseases; Coronary Artery Disease; Aortic Calcification; Stroke; Vascular Diseases; Vascular Calcification

Summary: aim and background: this study will seek to identify physiological and biochemical factors explaining and predicting a higher than expected central (aortic) blood pressure (bp) in patients with chronic kidney disease (ckd). the basic hypothesis of the study is that the degree of aortic calcification is an important component of elevated central bp, which, in turn, is important for the organ-damage and increased risk of cardiovascular disease associated with ckd. methods: adult patients with varying degrees of ckd undergoing scheduled coronary angiography (cag) at aarhus university hospital will be included in this study. during the cag procedure, systolic and diastolic bp is determined in the ascending part of aorta by a calibrated pressure transducer connected to the fluid-filled cag catheter. simultaneous with the registration of invasive aortic bp, estimation of central bp is performed using radial artery tonometry (sphygmocor®), while a corresponding brachial bp is also measured. prior to the cag, a non-contrast ct scan of aorta in its entirety will be performed to enable blinded quantification of calcification in the wall of aorta and coronary arteries. furthermore, echocardiography, resting bp measurement and a range of blood- and urine samples will be performed.


Eligibility criteria:
inclusion criteria: * age \>18 years * patient referred for planned cag at the department of cardiology, aarhus university hospital (auh) * egfr constantly either \>60 ml/min or \<60 ml/min in at least 2 separate blood-sample measurements over at least 3 months. * signed informed consent-form. exclusion criteria: * antihypertensive treatment changed within the last two weeks prior to the cag. * severe aortic valve stenosis (\<1 cm) as central hemodynamics may be altered * maximum number of patients in ckd-group already reached. * atrial fibrillation or other cardiac arrhythmia making radial pulse wave analysis (pwa) estimations impossible. * known significant stenosis of a. subclavia or a. brachialis * bilateral arteriovenous-fistula (even if one or both of these have been surgically removed) as this may significantly affect the pulse-wave form.
mapping and pacing of the his bundle for heart failure patients with left bundle branch block

Conditions: Heart Failure; Left Bundle-Branch Block

Summary: this is a prospective, single-arm, non-randomized, non-blinded study designed to characterize the locations of his bundle (hb) pacing that results in correction of electrical dyssynchrony and to characterize morphology and activation time of local intracardiac electrogram (iegm) with an electro-anatomical mapping system during a device implant procedure and secondarily to assess the efficacy of hb pacing or hb plus lv pacing (when indicated) in correction of electrical dyssynchrony in heart failure patients with left bundle branch block.


Eligibility criteria:
inclusion criteria: 1. patients are undergoing implant of an abbott pacemaker or crt device under standard indications 2. an ecg with a wide qrs complex (\>130 ms) 3. ecg morphology of typical complete lbbb, 4. patients have heart failure with nyha class ii-iv symptoms, 5. lv ef \<50% 6. at least 18 years old and not pregnant. 7. must provide written informed consent prior to any clinical investigation related procedure. 8. willing to comply with study evaluation requirements 9. female subjects of child-bearing potential are required to have a negative pregnancy test done within 7 days prior to the implant procedure per site standard test. female patients of childbearing potential should be instructed to use safe contraception (e.g., intrauterine devices, hormonal contraceptives: contraceptive pills, implants, transdermal patches hormonal vaginal devices, injections with prolonged release.) exclusion criteria: 1. patients have non-specific intraventricular conduction delay or right bundle branch block 2. previously implanted cardiac devices with three or more permanent leads 3. history of aortic valve repair or replacement 4. history of tricuspid valve replacement 5. pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period. 6. recent (\< 3 months) myocardial infarction, ablation, electrolyte imbalance, or any condition within the last 90 days that would contraindicate for pacemaker or crt implant in the opinion of the investigator 7. presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results.
comparison of m-tapa and tap blocks on postoperative analgesia in laparoscopic appendectomy surgeries

Conditions: Post Operative Pain

Summary: the goal of this study is to compare the analgesic efficacy of m-tapa block and tap block in patients undergoing laparoscopic appendectomy surgeries

there will be two randomized groups: group m-tapa (n=15), group tap (n=15). all patients will have standard general anesthesia. group m-tapa patients will receive bilateral m-tapa block with 0.25% bupivacaine (total volume of 40 ml). group tap patients will have bilateral lateral-tap block with 0.25% bupivacaine (total volume of 40 ml). all blocks will be performed after general anesthesia induction, before skin incision. all patients in the study will receive 50 mg dexketoprofen and 1 gr paracetamol intravenos (i.v.) 10 minutes prior to skin closure. all patients will have ibuprofen 3x400 mg in postoperative 24 hours (maximum dose 1200 mg/day). numerical rating scale (nrs) will be used to assess postoperative pain on 1st, 6th, 12th, 18th and 24th hour after the surgery. 50 mg tramadol will be administered as a rescue analgesic in all patients.total tramadol consumption will be calculated.

Eligibility criteria:
inclusion criteria: * adult patients older than 18 years of age who will undergo laparoscopic appendectomy under general anesthesia and will be american society of anesthesiologists (asa) i-ii-iii according to the asa risk classification. exclusion criteria: * patients who did not give consent, * patients with coagulopathy, * patients with signs of infection at the block application site, * patients using anticoagulants, * patients with local anesthetic drug allergies, * patients undergoing open surgery, * patients with unstable hemodynamics, * patients who could not cooperate during postoperative pain assessment

Keywords: m-tapa tap block laparoscopic appendectomy regional anesthesia postoperative pain
a multi-center randomised controlled study to evaluate laparoscopic versus open surgery for colorectal cancer

Conditions: Colorectal Cancer

Summary: laparoscopic surgery has been widely accepted for its minimal invasion and safety. however, whether it has the same survival benefit as the traditional open surgery in chinese population is still unknown. so we designed this study to evaluate the 3 year disease free survival rate in the laparoscopic group versus the open surgery group.


Eligibility criteria:
inclusion criteria: * informed consent * pathologically confirmed adenocarcinoma * pre-surgery image staging as (ct/mri):t2-3,n0-2,m0,(tnm stage，ajcc，version of 2003) * single tumor locating at cecum, ascending colon, descending colon, sigmoid colon, rectosigmoid junction, rectum(distance from anal verge more than 7cm) * tumor diameter less than 6cm * age 18-75 year * ecog 0-2 * predicted survival longer than 6 months * normal liver, renal, bone marrow function: (gpt less than 2 uln，total bilirubin less than 1.5mg/dl，cr less than 1.5 uln，wbc more than 4×109/l，plt more than 100×109/l) * no previous history of gastrointestinal surgery * no previous history of chemotherapy or radiotherapy exclusion criteria * severe and uncontrolled medical disease including unstable angina pectoris, cardiac infarction and cerebral attack in 6 months * could not tolerant general anesthesia or surgery for other organ dis-function * allergy to chemotherapeutical agents in the protocol * history of other malignant tumor within 5 years * severe mental disorder * continued systematic steroid therapy * woman during pregnancy or lactation * under study of other clinical trial * no compliance of the protocol * discovery of distant metastasis during surgery * postsurgery stage of i or iv tumors
comparison of 4-weeks of motor relearning program and mirror therapy in improving upper limb motor function in stroke patients.

Conditions: Acute Stroke

Summary: cerebrovascular accident(cva) or stroke is one of common condition affecting people in developed and underdeveloped countries. mrp is a therapy to regain particular motor function and neglecting accessory movements by engaging cognitive behavior. mirror therapy enhance functional activities in patient with hemiplegic stroke. for betterment of result high quality methodological studies and larger sample size is required.

cerebrovascular accident(cva) or stroke is one of common condition affecting people in developed and underdeveloped countries. mostly patient with stroke face many disabilities and the most important one is upper limb motor impairment. for the optimization of upper extremity and prevention of patient from permanent disability it is essential to promotes neuro-rehabilitation interventions. physiotherapy techniques need to be monotonous, thorough and task oriented for neuroplasticity to generate better recovery. there is notable enhancement in adls when the rehabilitation program starts within 16 hours to 6 months after stroke in improving upper extremity motor functions there are tremendous types of techniques used i.e. proprioceptive neuromuscular facilitation(pnf),brunnstorm, bobath therapy, motor relearning program(mrp),constraint induced movement therapy(cimt) and mirror therapy(mt).out of which we are using two basic techniques i.e. motor relearning program(mrp) and mirror therapy(mt).mirror therapy enhance functional activities in patient with hemiplegic stroke. for betterment of result high quality methodological studies and larger sample size is required. mirror therapy enhance functional activities in patient with hemiplegic stroke. mrp is a therapy to regain particular motor function and neglecting accessory movements by engaging cognitive behavior .mrp is a therapy to regain particular motor function and neglecting accessory movements by engaging cognitive behavior.

Eligibility criteria:
inclusion criteria * acute(hemiplegic attack within 1-2 weeks) and sub-acute stroke(hemiplegic attack within 3- 11 weeks). * 20 to 80 years. * no physical deformity prior to stroke * no history of serious underlying pathology and structural deformities. exclusion criteria: * patient with chronic hemiplegic stroke. * patient with congenital deformity.

Keywords: motor relearning program mirror therapy
combine effect of myofascial release technique and ocular muscle exercise among university students

Conditions: Headache

Summary: the current study aim to determine the effect of myofascial release technique and ocular muscle exercise to release eye strain headache in myopic students. this study aim to reduce eye strain headache to improve quality of life and student academic performance. this study will enable the students to to work on digital device for a long period of time without any discomfort.

according to recent researches mfr technique used to relax the muscles tension in muscles and fascia. this technique also enhance rom. in this technique apply gentle and sustain pressure on muscle start with light pressure gradually increase as it tolerated move the fingers along the length of muscle during apply pressure to take deep breath to help relax and facilitate the release. previous study showed a significant improvement in reduction of the number of headache days (p \< 0.001) and the headache pain level (p \< 0.001) following treatment. the other intervention of this study is the ocular muscle exercise. previous study showed that strengthening neck exercises like isometric neck exercise improve muscular strength and it is also delivering long term treatment effect on cervical pain. this study divide in to two groups. group a (experimental group) and group b (control group)patient in group a will receive ocular muscle exercise which is consist of three exercise like palm exercise, blinking exercise, pencil pushup exercise this group will also receive myofascial release technique on sternocleidomastoid muscle and upper trapezius muscles. patient in group b will receive ocular muscle exercise and neck isometric exercise. this study will manage the musculoskeletal and visual aspects of headaches and eye strain by combining myofascial release treatments with eye exercises. this study will contribute to reduce the eye strain headache and improve their quality of life and improve students' academic performance during class room and online learning.

Eligibility criteria:
inclusion criteria: * age = 20- 30 years old * gender= male / female * diagnosed of mild (-0.50 to -3.0 d) and moderate ( -3.0 to -6.0 d) myopia * unilateral or bilateral headache with mild or medium intensity * pain around eyes, forehead and temples * headache with neck stiffness or pain * headache increase with visual activity such as reading, using computer or cell phone. * headache associate with triggers in sternocleidomastoid, upper trapezius * positive convergent test (13) exclusion criteria: * history of genetic disease * history of refractive surgery * wear contact lenses * headache associate with photophobia * headache associate with phonophobia * history of neck trauma * cervical radiculopathy, herniated disc, arthritis * pain aggravated by movements of head
the healthy cantonese diet on cardiometabolic syndrome

Conditions: Cardiovascular Diseases; Cardiovascular Risk Factor; High Blood Pressure; Hypertension; Hyperlipidemias; Hyperglycemia

Summary: the dash diet (dietary approaches to stop hypertension) have been proven to lower risk of cardiovascular diseases. but the dash diet is inconsistent with chinese dietary pattern. in this study, based on the typical cantonese diet, the healthy cantonese diet is developed according to the dash diet and the balanced dietary pattern of the chinese dietary guidelines 2016. the randomized control trial is designed to investigate whether the healthy cantonese diet has benefit to blood pressure, blood lipid, blood glucose and other cardiometabolic biomarkers among adults with cardiometabolic syndrome in guangdong, china.


Eligibility criteria:
inclusion criteria: 1. age 25-75 years old, male or female; 2. have lived in this community for the past six months, and have no plans to move out or go out in the next three months; 3. the systolic blood pressure is within 130-159mmhg regardless of medication. 4. maintaining the current medication (mainly drugs for hypertension, diabetes or hyperlipidemia) throughout the research period, with the category and dose unchanged; 5. the number of test meal consumed is no less than 18; 6. community feeding mode: eat a meal at least once a day at the research center (preferably lunch or dinner); or home delivery mode: upload meal pictures for three meals every day, and eat a meal and have physical examination at the research center at least once a week; 7. sign the informed consent form. exclusion criteria: 1. fasting blood glucose ≥10.0mmol/l; 2. total cholesterol ≥7.2mmol/l; 3. injected inulin within a month; 4. unwilling or unable to change the original dietary pattern, or have special dietary needs (such as vegetarians); 5. alcoholism; 6. bmi ≥30kg/m\^2, or losing weight currently; 7. have acute cardiovascular and cerebrovascular events occurred in the past six months; 8. have a history of chronic kidney disease, intestinal irritation or asthma; 9. women who have been/are preparing for pregnancy or lactation; 10. in combination with other serious diseases such as cancer, chronic heart failure, severe depression or other mental disorders, long-term bedridden or unable to move freely; 11. have a history of common food allergies (eggs, seafood, peanuts, etc.); 12. have undergone gastrointestinal surgery; 13. currently suffering from acute phase of diseases such as respiratory infections, fever, severe diarrhea; 14. have deaf-mutism, dementia, unable to communicate properly.

Keywords: dash diet trial cardiovascular disease blood pressure