Kornimate/medical-research-clean huggingface dataset:
physiology of weakness in movement disorders

Conditions: Movement Disorders

Summary: this study will compare electroencephalograph (eeg) recordings in healthy volunteers and in people with movement disorders to examine brain activity associated with the weakness. eeg records the electrical activity of the brain ("brain waves"). healthy volunteers and patients with arm or leg weakness who are between 18 and 80 years of age may be eligible for this study. healthy subjects are screened with a medical history, physical and neurological examinations, and a questionnaire. they must be right-handed and never have had a neurological disease or head trauma. all participants have an eeg. an elastic cap with electrodes is placed on the subject's scalp to record the brain's electrical activity. during the eeg, subjects are required to resist against a force with their arm, elbow, shoulder or leg for as long as they can. several recordings are done with short breaks between them.

objective give way weakness is a symptom often associated with psychogenic etiology, but its neurophysiological basis is poorly understood. our objective in this study is to identify the cerebral mechanism of give way weakness. study population we will study 6 patients with give way weakness and 6 healthy volunteers all age 18 years old or older. design in this study, patients will try to resist against the examiner's force and subsequently give way. electroencephalography (eeg) will be recorded while this maneuver is performed repeatedly. outcome measures movement-related cortical potential (mrcp) analysis will be performed on the data and its amplitude (in volts) and latency (in seconds) in each individual patient will be described in contrast to the data obtained from healthy volunteers.

Eligibility criteria:
* inclusion criteria: * both patients and healthy volunteers will be between age 18 and 80. * patients will be evaluated in the human motor control clinic at ninds. * the definite diagnosis of the disease may not be completely established at the time of recording. * patients have clear and reproducible symptoms of give way weakness of either upper or lower extremities. * patients have to be able to resist against the examiner for at least two seconds before giving way. * healthy volunteers are right handed adults without history of neurological disease or severe head trauma. exclusion criteria: * subjects (patients or volunteers) who cannot understand the instructions and consent forms of the protocol will be excluded. * subjects who cannot follow the instruction during the entire recording for whatever reason will be excluded. * patients with a documented organic central nervous system lesion may be excluded from the study. this will be discussed in detail for each individual subject at the human motor control clinic.

Keywords: movement-related potential electroencephalogram psychogenic movement disorders psychogenic movement disorder healthy volunteer hv
tqb2450 combined with anlotinib hydrochloride in the perioperative treatment of hepatocellular carcinoma hydrochloride neoadjuvant therapy for resectable hepatocellular carcinoma with a high risk of recurrence or metastasis

Conditions: Patients With Resectable Hepatocellular Carcinoma Who Are at High Risk of Recurrence or Metastasi

Summary: in this study, single cell transcriptome sequencing will be performed on the tissue samples punctured and the surgically resected specimens to explore the gene mutation sites related to efficacy


Eligibility criteria:
inclusion criteria: 1. voluntary participation and written informed consent; 2. age: 18-75 years old;ecog ps：0-1；the expected survival is more than 6 months; 3. no gender limitation; 4. histologically confirmed hepatocellular carcinoma; 5. meet resectable surgical criteria; 6. child-pugh:a or b; 7. according to recist 1.1, there is at least one evaluable lesion that has not been treated; exclusion criteria: 1. fibrolamellar hcc, sarcomatoid hcc, or mixed bile duct cell-hcc is known to exis; 2. preoperative systemic treatment including chemotherapy, targeted therapy and immunotherapy;preoperative local treatment including radiotherapy, interventional therapy and ablative therapy; 3. no radical resection could be performed after adequate imaging evaluation; 4. present or present with other malignant tumors within 3 years.two conditions were eligible for inclusion: 5 consecutive years of disease-free survival (dfs) for other malignancies treated with a single operation;cured carcinoma in situ of the cervix, non-melanoma skin cancer, and superficial bladder tumor \[ta (non-invasive tumor), tis (carcinoma in situ), and t1 (tumor infiltrating basement membrane)\]; 5 . there are many factors that affect oral medications (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.); 6. hepatitis b combined with hepatitis c; 7. patients with portal hypertension have high bleeding risk considered by the researcher, or gastroscopy or gastroscopy confirmed red signs, or gastroscopy found active ulcers with high bleeding risk;
high doses of candesartan cilexetil on the reduction of proteinuria

Conditions: Proteinuria

Summary: the purpose of this study is to assess the effects of high doses of candesartan cilexetil and also to assess which dose (16mg, 64mg, 128mg) is the most optimal for the maximum reduction of proteinuria.


Eligibility criteria:
inclusion criteria: * informed consent * stable hypertension defined as no new antihypertensive medication started within 6 weeks of visit 1 * minimum 6-month history of hypertension and primary glomerular disease * hypertensive nephrosclerosis * diabetic nephropathy with stable proteinuria as defined by ≥ 1g/24 hours on more than one occasion within 6 months prior to visit 1 exclusion criteria: * persistent hypertension * new anti-hypertensive medications started within 6 weeks of visit 1 * significant cardiac disease or liver disease * females of childbearing potential without reliable contraception * pregnant women and women who are breast-feeding

Keywords: hypertension
the hematologic impact of umbilical cord milking versus deferred cord clamping in premature neonates.

Conditions: Delayed Cord Clamping; Umbilical Cord Milking; Preterm Neonates

Summary: comparing the beneficial effect of cord milking versus deferred cord clamping in preterm neonates. a randomized controlled trial

placental transfusion either by deferred cord clamping or umbilical cord milking became standard care and recommended management especially in preterm deliveries.1 in average, about 80 ml of blood was found to be transferred to the neoborn by one minute after birth.2 this additional blood can afford extra iron and blood volume giving the benefit of less iron deficiency anemia during the first year of life, less need for blood transfusion, less need for vasopressors and less intraventricular hemorrhage (ivh) by 50%.3 placental transfusion with different techniques proved safety with no significant risks regarding postpartum hemorrhage, polycythemia, jaundice, apgar score or admission rates.4 our study aims to compare delayed cord clamping with umbilical cord milking as the best way for placental transfusion for preterm neonates.

Eligibility criteria:
inclusion criteria: • gestational age 24 to 34+6 weeks exclusion criteria: * category iii ctg * monochorionic twins * significant antepartum hemorrhage * iugr or rh incompatibility
effect of tranexamic acid on reducing postoperative blood loss in cervical laminoplasty

Conditions: Cervical Myelopathy

Summary: the purpose is to evaluate the efficacy of tranexamic acid in cervical laminoplasty; the surgical procedure used was identical in all cases.

tranexamic acid, an inhibitor of fibrinolysis, has proven to be effective in reducing perioperative blood loss in patients undergoing total hip and knee arthroplasty. however, limited numbers of well-controlled trials in spinal surgery have been conducted due to heterogeneity in the performed surgical procedures.

Eligibility criteria:
inclusion criteria: * patients who were scheduled to undergo cervical laminoplasty from c3 to c6 for cervical multilevel compressive myelopathy with a narrow spinal canal for which nonoperative therapy had failed. exclusion criteria: * patients with chronic renal failure, cirrhosis of the liver, serious cardiac disease, allergy to txa, a history of thromboembolic disease, and bleeding disorders, as well as those who were currently receiving antiplatelet and/or anticoagulant drugs, were excluded from this study.

Keywords: perioperative blood loss, spinal surgery
acupuncture safety/efficacy in knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: the goal of this research is to determine the efficacy and safety of traditional chinese acupuncture (tca) in patients with osteoarthritis of the knee. a three arm randomized controlled trial (rct) using sham tca, true tca, and an education/attention comparison group with a total sample of 525 is proposed. primary hypothesis to be tested is that patients randomized to true tca will have significantly more improvement in pain and function as measured by the womac pain \& function scales and patient global assessments than patients randomized to the sham acupuncture and education/attention control groups. secondary aims of the study are to 1) determine if improvement with tca differs between patients below age 65 vs. those aged 65 and above, 2) to determine if improvement with tca differs by racial/ethnic group (ie., caucasian, black, hispanic), and 3) to determine if improvement with tca differs by stage of radiographic severity of knee oa at baseline (kl grade 2, 3 or 4)


Eligibility criteria:
inclusion criteria: * diagnosis of osteoarthritis of the knee (fulfilling acr criteria) for at least 6 months duration * at least moderate pain in the knee for most days in the last month * must be taking analgesic or nonsteroidal anti-inflammatory agents for control of pain * documented radiographic changes of osteoarthritis (kellgren-lawrence grade\>2) at the time of rheumatological screening * signed informed consent

Keywords: acupuncture osteoarthritis elderly
level of her2-neu gene amplification an response to trastuzumab

Conditions: Advanced Breast Cancer

Summary: primary objective of the study is to evaluate the correlation between level of her2-neu gene amplification evalued by dual-color fluorescent in-situ hybridization (fish) test and time to progression (ttp) in patients with her2-positive advanced breast cancer treated with trastuzumab-containing regimens.


Eligibility criteria:
inclusion criteria: * her2-positive breast cancer trastuzumab-containing regimen delivered for advanced disease tumor sample available at pathology archive exclusion criteria: * her2-negative advanced breast cancer pretreatment with trastuzumab
moletest clinical study in scotland

Conditions: Melanoma

Summary: to evaluate an ipad based photoimage analysis system (moletest) for improving discrimination of benign from malignant suspicious skin lesions or moles. specifically the objective is to demonstrate that the moletest system is able with a sufficient degree of confidence (95%) to identify lesions which are benign


Eligibility criteria:
inclusion criteria: all patients referred to the dermatology department, lanarkshire hospitals during a period to be defined for assessment of suspicious skin lesions (cutaneous moles) will be eligible for inclusion in the study. there are no age limits but patients under the age of 18 years will also have their inclusion subject to parental/guardian consent exclusion criteria: there is no exclsion criteria
therapeutic effects of a new upper limb robot assisted therapy device for persons after stroke

Conditions: Stroke

Summary: the purpose of this pilot study is to investigate the clinical effects of a new upper limb robot assisted therapy device that is linked to a virtual therapy environment in patients with stroke.

the number of physically weak individuals is increasing, resulting in a higher burden on health care and health care workers. the use of robot assisted therapy (rat) might partly solve this problem. rehabilitation progress highly depends on training intensity and training duration, favouring the use of rat. in this pilot study, the clinical effects of using a new upper arm rat device for upper arm rehabilitation in patients with stroke is investigated. myo-electrical signals will serve as input for the device, assisting the user in flexion and extension of the elbow. the device is coupled to a virtual environments, creating a stimulating therapy environment.

Eligibility criteria:
inclusion criteria: * patients with stroke, more than three months post onset * no or moderate spasticity in the upper limb (maximum score of 3 on modified ashworth scale) * observable voluntary muscle activity in biceps and triceps muscle of the affected upper limb (minimal score of 1 on the medical research council score) * able to sit on a chair with adequate trunk stability * able to follow verbal instructions * able to communicate verbal information to the researchers exclusion criteria: * patients who are medically unstable * cognitive disorders impeding the intervention * visual disorders impeding the intervention * subluxation of the shoulder joint * pusher syndrome

Keywords: upper extremity rehabilitation robot assisted therapy robotics devices orthosis clinical outcome
endoscopic vessel harvesting during coronary bypass surgery

Conditions: Coronary Arteriosclerosis

Summary: conventional open vein harvesting from the legs during coronary artery bypass surgery result in wound complications among 30% of the patients. endoscopic harvesting decrease the complication rate, but it remains to be shown whether this is also a fact among patient in whom only short segments of veingraft material is needed from the leg. we hypothesise that the rate of wound complications will be reduced and the patient satisfaction will be increased also among patients in whom only short vein segments are endoscopically harvested compared to conventional open vein harvesting.

conventional open vein harvesting from the legs during coronary artery bypass surgery result in wound complications among 30% of the patients. endoscopic harvesting decrease the complication rate, but it remains to be shown whether this is also a fact among patient in whom only short segments of veingraft material is needed from the leg. we hypothesise that the rate of wound complications will be reduced and the patient satisfaction will be increased also among patients in whom only short vein segments are endoscopically harvested compared to conventional open vein harvesting. preoperative demographic as well ass peri- and postoperative data are collected prospectively at 5-7 days and 1 month postoperatively. wound complications are registered as well as post operative pain in the wound is evaluated using af visual analogue scale. patients are evaluating the cosmetic results after wound healing.

Eligibility criteria:
inclusion criteria: * elective coronary artery bypass surgery exclusion criteria: * leg wounds * acute surgery * previous vascular surgery * combined surgery (valve + coronary) * arterial revascularization

Keywords: endoscopic vein harvesting saphenous vein
pediatrics owning performance study

Conditions: Diabetes Mellitus, Type 1

Summary: a more convenient blood glucose monitoring system integrated with a responsive mobile health app may facilitate improved diabetes control in adolescent and young adult patients with type 1 diabetes. the primary aim of this study is to determine if the pops diabetes management system can improve diabetes control in the adolescent and young adult population. the investigators hypothesize that use of the pops diabetes management device and mobile application (app) will be associated with lower hba1c after 6-months of use in adolescent and young adult t1d patients.

this is a prospective, single-arm, single-subject clinical trial to study outcomes related to device use in the pediatric diabetes population. patients will be recruited at the children's minnesota mcneely diabetes clinic and satellite clinics during routine office visits over a 6-month period until recruitment goals are met. enrolled subjects will be given a pops! device (meter, lancet/test strips, and software app) to use for 6 months with periodic check-ins and follow-ups. primary outcome, hba1c, will be measured at baseline and 6-month follow-up. secondary aims include assessment of blood glucose testing frequency and quality of life scores following 6-months of device and app use. the investigators will also describe sustained use over the study period, average blood glucose and variability, and frequency of hypoglycemic events (blood glucose \<70). historical data for each patient will also be recorded from medical records, with each patient serving as their own comparative control.

Eligibility criteria:
inclusion criteria: 1. type 1 diabetes, diagnosed at least 6 months prior to enrollment 2. aged ≥10 years, ≤25 years 3. daily insulin of any type, administered as multiple daily injections (mdi) for at least 90 days prior to enrollment 4. latest hba1c ≥8.0%, ≤10.5% 5. average self-blood glucose measurement frequency ≥2 per day and ≤4.5 per day based on meter download spanning 28-day period prior to qualifying hba1c measurement 6. user of iphone 5 or above with ios above 10.0 7. english-speaking 8. patient must be willing to only use pops device to check blood glucose for duration of study (except in case of technical failure or emergency) exclusion criteria: 1. continuous glucose monitor user at time of enrollment or considering cgm use in the next 6 months 2. concurrent participation in another study that may influence results 3. on insulin pump at time of recruitment or considering pump use in the next 6 months 4. inability to perform self-care behaviors due to co-morbidities such as mental health disorder, developmental delay, or other prohibitive physical condition (blindness, etc) 5. participation in a diabetes clinical trial intervention in the 12 months prior to enrollment

Keywords: diabetes mellitus, type 1 self-monitoring blood glucose diabetes mobile application diabetes management device
efficacy of antenatal steroids in reducing respiratory morbidities in late preterm infants

Conditions: Respiratory Distress Syndrome, Newborn; Transient Tachypnea of the Newborn

Summary: the hypothesis of the study is that administration of antenatal steroid to women at high risk of preterm birth after 34 weeks of gestation would reduce the risk of respiratory complications, specifically respiratory distress syndrome (rds) or transient tachypnea of the newborn (ttn) in late preterm babies.


Eligibility criteria:
inclusion criteria: * women between 34 0/7- 36 6/7 weeks of gestation * high risk of preterm birth exclusion criteria: * multiple births * fetal congenital malformations * a course of steroids within 2 weeks of randomization * multiple courses of steroids * chorioamnionitis * non reassuring fetal heart rate * obstetrical indication of delivery * active bleeding * pregnancy related hypertensive disorders * uncontrolled diabetes

Keywords: respiratory distress antenatal steroids late preterm
long-term effects of wise program improving frailty status and quality of life for adolescents with chd

Conditions: Frailty

Summary: most children with congenital heart disease (chd) are expected to survive until adulthood. in addition to physical limitations, the growing adolescents with chd are also challenged at the psychosocial domains. previous studies have investigated the frailty of elderly, but the research on the intervention to the frailty of adolescents with chd has been limited. the aims of this study will apply the walking instruction based on self-efficacy (wise) program to examine the long-term effects of improving frailty state and quality of life for adolescents with chd.

this proposal will conduct a three-year series of studies. in the first year, a cross-sectional survey will be used to evaluate the applicability of the fried frailty index to adolescents with chd, and to examine the correlation between frailty index and quality of life in adolescent patients. in the second year, investigators will conduct individual in-depth interviews with selected pre-frailty/frailty adolescent participants and their main caregivers to gain insights into their views, connotations and support needs for frailty, which will serve as the basis for the design of the next interventional study. in the third year, the wise program will be developed to provide 12-week walking self-efficacy improvement education strategies and exercise bracelets with heart rate monitoring. the recruited pre-frailty/frailty adolescent participants will be randomly assigned to experimental and control groups respectively in the pretest-posttest control group design. the changes in frailty state and quality of life for the two groups will be evaluated at 6, 12 and 24 weeks. the results of this study can provide frailty evaluation indicators for adolescents with chd, timely detect the pre-frailty stage, and provide an important reference for the prevention of frailty intervention for adolescents with chd as early as possible.

Eligibility criteria:
inclusion criteria: 1. aged between 12-18 years old. 2. congenital heart disease diagnosed by a doctor before the age of 2. 3. the american new york heart association (nyha) classifies the cardiac function as i-iii grades. 4. adolescents and their parents or guardians can communicate in mandarin and taiwanese and have normal cognitive abilities. 5. those who are willing to cooperate with the research and complete the consent form. exclusion criteria: 1. received a heart transplant within one year. 2. have undergone open-heart surgery within six months. 3. the new york heart association (nyha) classifies the cardiac function as class iv. 4. combined with other congenital diseases.

Keywords: chd, adolescents, quality of life, walking