Kornimate/medical-research-clean huggingface dataset:
prevalence of cerebral small vessel disease in hiv infected patients

Conditions: HIV Seropositivity

Summary: cerebral small vessel disease (csvd) is a major cause of cognitive impairment and disability in the general population, secondary to the accumulation of asymptomatic elementary lesions. csvd is directly correlated with age and cardiovascular risk factors and therefore would be challenging in term of public health care in the future. while hiv patients share the same cardiovascular risk factors and they are often diagnosed with cognitive impairment and frailty, csvd has not been yet described in this population. the global aim is to compare the prevalence of csvd in a well controlled hiv+ population compared to hiv- controls matched with age and sex. 500 hiv+ patients and 250 age- and sex- matched controls will undergo a screening of the csvd with a 10 minutes mri (flair and t2\*). prevalence of the csvd will be compared between hiv+ patients and controls. general and hiv-specific parameters from their electronic medical records will be compared between hiv+/csvd+ and hiv+/csvd- patients. we are expecting to prove that csvd is more frequent in hiv+ population.


Eligibility criteria:
inclusion criteria: * age over 50 * chronic hiv seropositive patient infected for at least 5 years * treated with any antiretroviral (arv) therapy * plasmatic hiv viral load \<40 copies/ml for at least one year with one authorized blip \< 1000 copies/ml per year exclusion criteria: * co-infection with hepatitis c virus (hcv) * uncontrolled high blood pressure (who criteria) * personal history of cerebral infarction or cerebral ischemia * personal history of neurological complication of the hiv-infection * use of illegal drugs (except cannabis or poppers) * glomerular filtration rate \< 15 ml/mn * complicated diabetes mellitus (glomerular filtration rate \ 300 mg and/or retinopathy)
definition of surgical technique of lymphadenectomy and complete mesocolon excision for radical right colectomy: a delphi consensus

Conditions: Colon Cancer

Summary: a delphi consensus to define surgical steps of lymphadenectomy and complete mesocolic excision for radical right colectomy


Eligibility criteria:
inclusion criteria: * experts in the fields of radical right colectomy exclusion criteria: * panelists who were not able to commit to all rounds of the modified delphi process
improvement of live babies rates after icsi, using cpft

Conditions: Infertility; Oocyte; Pregnancy

Summary: demonstrate the improvement of the live births rate after icsi by supplementing the pre-icsi incubation medium of oocytes and that of preimplantation embryos with cpft at the 1st embryo transfer for women under 37 years old.

supplementation of the incubation medium with cfee should improve the implantation rate and art outcome. as in france icsi is widely used to achieve good fertilization rates, we decided to use icsi to fertilize the egg, and the peptide: 1. to improve chromosome segregation during meiosis, and 2. to improve in vitro embryogenesis after icsi. hence the protocol includes an oocyte preincubation step prior to icsi and a co incubation of the embryo with the molecule during blastocyst formation. hence our protocol includes: 1. - a preincubation of the decoronized oocytes with the peptide prior to icsi, and 2. - a coincubation of the developing embryo with the molecule. the principal criteria will be the live baby rate after the first embryo transfer (using the best embryo). as the oocyte loses its strength as the women is getting older, the main criteria will be evaluated for women under 37 years old. randomization: every couple will be randomly assigned to the control or the treated group. treated group: after egg retrieval, the oocyte will be decoronized and incubated prior to icsi procedure into cscm-c (irvine) medium supplemented with the molecule. control group: similar protocol of incubation but without the molecule. after icsi the zygote will be incubated until the blastocyste stage in cscm-c medium (irvine). embryo transfer will be limited to only one blastocyst, fresh or delayed after cryopreservation.

Eligibility criteria:
inclusion criteria: * couples eligible for a first attempt at assisted reproduction (amp). * couples asking for assisted reproductive technology, and requiring an ics procedure. * women aged 18 to 36 inclusive. * men aged 18 to 58 inclusive * use of cscm-c culture medium from biocare / irvine, exclusively. * people affiliated to a social security scheme exclusion criteria: * lack of consent * early menopause. * couples under ivf or intra uterine insemination treatment. * people unable to follow protocol visits in france. * couple with a contraindication to treatment with art. * women with a contraindication to treatment with art or an associated pathology such as: hypertension, risk of eclampsia, family genetic problems, diabetes, uterine partitions, synechiae adhesions, adenomyosis or any other contraindication judged as such by the investigator. * art with donation of gametes or embryos. * participant under guardianship or guardianship

Keywords: infertility femal infertility assisted reproduction technology outcome
technical evaluation of cardiovascular magnetic resonance imaging and spectroscopy

Conditions: Cardiovascular Disease; Healthy

Summary: magnetic resonance imaging (mri) and spectroscopy are diagnostic tools that create high quality images of the human body without the use of x-ray (radiation). mri uses different levels of magnetic fields to create images of the body and organs. occasionally, researchers will give patients undergoing a mri an injection of a contrast substance. the contrast substance works by brightening areas of the magnetic resonance image. in this study researchers plan to use magnetic resonance imaging with contrast substances and exercise on normal volunteers in order to evaluate different aspects of its performance. information gathered from this study may be used to develop more specific research studies involving mri....

technical evaluation of magnetic resonance imaging and spectroscopy will be performed on normal volunteers. these studies will be conducted in the nih mri systems located in suburban hospital in bethesda, maryland. these studies may involve the intravenous administration of commercially available mr contrast media and exercise. the results will be used to evaluate the performance of various pulse sequences, gradient coils, and rf coils on human subjects and will provide essential ground work for specific patient protocols.

Eligibility criteria:
* inclusion criteria: any normal volunteer above the age 18 who is capable of giving informed consent will be included. exclusion criteria: a subject will be excluded if he/she has a contradiction to mr scanning. 1. brain aneurysm clip 2. implanted neural stimulator 3. implanted cardiac pacemaker implanted defibrillator 4. cochlear implant 5. ocular foreign body (e.g. metal shavings) 6. insulin pump 7. pregnant women (when uncertain, subjects will undergo urine or blood testing). 8. kidney 9. paralyzed hemidiaphragm 10. morbid obesity 11. claustrophobia 12. any condition in the pi's judgement which present unncessary risk exclusion criteria for gadolinium enhanced studies: 1. lactating women 2. subjects with hemoglobinopathies 3. asthma 4. renal or hepatic disease subjects will be excluded if it is deemed that they have a condition that would preclude their use for technical development (e.g. paralyzed hemidiaphragm, morbid obesity, claustrophobia etc.) or present unnecessary risk (e.g. pregnancy, surgery of uncertain type, etc.). lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the adminstration of contrast agents.

Keywords: imaging spectroscopy mri cardiovascular technical development safety gadolinium heart toxicity adverse events normal volunteer
the effects of aromatherapy on the incidence and severity of acute pain

Conditions: Venipuncture

Summary: the purpose of this research was to estimate feasibility of an aromatherapy pain management intervention to reduce pain and distress caused by venipunctures in a pediatric population. the feasibility of the use of aromatherapy essential oil lavandula angustifolia for pain management intervention (treatment group) was compared to placebo aromatherapy with jojoba oil (placebo control group) and to the current standard of care, which is no oil during a venipuncture (standard of care control group). primary measured outcomes were assessed using a double-blind randomized design. the physiological measure of heart rate was taken over the course of four minutes at three different intervals to note the pattern of change that occurs during anticipatory anxiety resulting from the impending procedure, the procedural pain experienced during the venipuncture, and the residual fear common after completion of the venipuncture procedure. the visual analogue scale (vas) for pain and the hospital fears rating scale (hfrs) were administered to measure subjective pain and anxiety. participants (n=21) were recruited from the laboratory medicine unit of children's national health system. feasibility was estimated based on the ability to inhale the full dose of oil without adverse effects and and ability to inhale the full dose within the ten-minute time frame. this study analyzed the effect of the aromatherapy pain management intervention, lavandula angustifolia aromatherapy, on the stress response of a pediatric population through observation of physiological and psychological indicators of pain and distress, in order to learn more about the pain and anxiety experienced during venipuncture and the use of aromatherapy to decrease pain and anxiety during venipuncture.


Eligibility criteria:
inclusion criteria: * scheduled for venipuncture * english speaking * parental written consent * child's verbal assent exclusion criteria: * essential oil allergy * peanut allergy (nut oils processed by manufacturer) * medical hypersensitivity to smell * asthma triggered by foreign scent * frequent venipuncture (5 or more a year) * current pain or anxiety medication

Keywords: aromatherapy pediatric venipuncture lavender pain management
community based screening for colorectal cancer in an underserved high risk population in nigeria

Conditions: Colorectal Cancer

Summary: patient age 45 year old and above who presented with rectal bleeding at three tertiary hospitals in south west nigeria were invited for colonoscopy. the clinical information of the patients and the colonoscopy data were analyzed

patient age 45 year old and above who presented with rectal bleeding at obafemi awolowo university teaching hospitals complex, ile ife, nigeria, university college hospital, ibadan, nigeria, and university of ilorin teaching hospital, ilorin nigeria were invited for colonoscopy. categorical variables were compared using χ2-test or fisher's exact test while the kruskal-wallis test was used for quantitative variables. multivariate analysis was performed using logistic regression model. all statistical tests were two-sided and p-values below 0.05 were considered statistically significant. statistical analysis was carried out using sas 9.4 and r 3.3.1.

Eligibility criteria:
inclusion criteria: * must be 45-years of age or older * has rectal bleeding lasting at least one week * has had a complete colonoscopy performed exclusion criteria: * individuals with a personal history of inflammatory bowel disease, colorectal polyps, colorectal adenoma or crc * individuals with a family history of familial adenomatous polyposis syndromes or other hereditary polyposis syndromes, hereditary nonpolyposis colorectal cancer * individuals with severe comorbidities that were contraindication to colonoscopy * individuals who had a previous history of colectomy

Keywords: colorectal cancer polyps colonoscopy rectal bleeding nigeria
the effect of exercise on disease activity and cardiovascular risk for patients with axial spondyloarthritis

Conditions: Axial Spondyloarthritis

Summary: the overall aim of this multicenter randomised controlled trial (rct) is to investigate if exercise can modify the disease course and prevent comorbidity in patient with spondyloarthritis (spa).

international guidelines recommend exercise as a cornerstone in the management of spa. due to the typical features of spa with reduced spinal mobility, the main focus for exercise has been flexibility exercise. exercise trials for this patient group have mainly aimed at improving spinal mobility and there is limited evidence of the potential effects of exercise on disease pathogenesis and cvd risk factors.

Eligibility criteria:
inclusion criteria: 1. diagnosis of axial spa (the assessment of spondyloarthritis international society classification criteria) confirmed by a rheumatologist 2. age, 18-70 -years 3. steady medication for ≥3 months 4. moderate disease activity defined as a basdai score of ≥3.5 or a patient global score ≥3.5 5. not participated in a structured endurance and strength exercise program during the last 6 months (\>1 hour/week) exclusion criteria: 1. severe co-morbidity which involves reduced exercise capacity and/or contraindications for physical activity as per american college of sports medicine guidelines for exercise testing 2. not able to participate in weekly exercises sessions 3. pregnancy
development and clinical validation of early-stage lung cancer prognostic kit

Conditions: Lung Cancer; Surgery; Recurrence

Summary: lung cancer is the leading cause of cancer mortality worldwide in spite of the advanced progresses in medication and low-dose ct screening. the early-stage lung cancer accounts for less than 50% of newly diagnosed lung cancer in taiwan, even in stage ib patients proximately 30% still suffer from recurrence and metastasis. the international cancer moonshot project recently established the first comprehensive proteogenomics profiling of early-stage lung cancer patients in east asia, revealing a proteomics-informed classification to identify a new "late like" subtype, which can identify a subgroup of early-stage patients with worse clinicopathological features (cell, cover story, 2020). this study has been featured in prestigious journals (nat rev clin oncol; cancer discov, 2020) and led to two provisional us patents. in this proposal, taking the discovery from the cancer moonshot multiomics database, the investigators aim to translate these findings into clinical utilities. two subprojects are proposed. (1) validation of "late-like" protein markers for identifying high-risk early-stage lung cancer: two ivd kits will be developed, including high-risk early-stage lung cancer ihc prediction kit for tumor staining and high-risk early lung cancer elisa prediction kit for noninvasive diagnosis. (2) conducting a prospective clinical trial to evaluate the accuracy of high-risk early-stage lung cancer ihc prediction kit and high-risk early-stage lung cancer elisa prediction kit.


Eligibility criteria:
inclusion criteria: * willing to sign and provide subject consent. * male or female of age 20 or older. * patients diagnosed with lung adenocarcinoma by tumor pathology. * lung cancer with the pathological stage of ia/ib/ii/iiia according to the american joint committee on cancer staging manual (8th edition). * complete tumor resection (r0 resection). * the east coast cancer clinical research collaborative (ecog) performance status was 0 or 1 at the time of grouping. * those willing to provide tumor tissue or cytology specimens (including surgical specimens, tissue biopsy specimens, or cytology specimens), blood and body fluid specimens (for follow-up or disease recurrence, such as urine, malignant pleural effusion, ascites, pericardial fluid, etc.). exclusion criteria: * not primary lung cancer patients. * lung cancer patients whose pathological stage is not ia/ib/ii/iiia according to the american joint committee on cancer staging manual (8th edition) after surgery. * patients with uncontrolled malignant tumors other than lung cancer. * uncontrolled systemic disease (such as diabetes, hypertension, active infection, etc.) (determined by the principal investigator ) * pregnant women. * any condition may put the patient at serious risk, may affect the interpretation of the trial results, or may seriously interfere with the patient's participation in the trial.

Keywords: lung cancer immunohistochemistry enzyme-linked immunosorbent assay laboratory developed tests recurrence
pedialyte or gatorade for viral gastroenteritis in adults: a randomized, controlled trial

Conditions: Gastroenteritis

Summary: background: pedialyte and gatorade are advocated for the treatment of dehydration in viral gastroenteritis, but there is limited evidence to support their use. objective: to examine the efficacy, safety and palatability of pedialyte, gatorade, and a new oral rehydration solution (ns). design: randomized double blind. setting: inpatient, community hospital. patients/interventions: 75 consecutive adult patients (m/f=44/33) admitted with viral gastroenteritis were randomized to receive gatorade, pedialyte or ns for 48 hours. a yogurt/rice diet was allowed ad libitum. measurements: stool and urine output, electrolytes, fluid intake, body weight, hematocrit and palatability of solutions. limitations: smaller sample size and higher drop out (20%).


Eligibility criteria:
inclusion criteria: * subjects were included if they had mild-to-moderate diarrhea, with mildly sunken eyes and a clinical assessment of dehydration of less than 5%, a serum sodium concentration between 130-150 meq/l, adequate general health and nutrition, a bun/creatinine ratio of \>20 and with a normal pulse rate for age and degree of fever and adequate skin turgor exclusion criteria: * patients were excluded if they had hyperthermia (\>39.0º c), serum sodium \>150 meq/l or \ 15,000, bloody diarrhea (dysentery), abnormal cardiovascular or renal function or an underlying metabolic or nutritional disorder and most importantly, if the clinical assessment of dehydration was \>7% that suggested a need for intravenous fluids.
postnatal nutrition and physical activity in obese asthmatic children

Conditions: Obesity; Asthma in Children

Summary: the aim of this study was to compare the duration of breast milk intake, vitamin d intake, asthma control level and physical activity levels between obese asthmatic children and non-obese children. this was a prospective study in children aged 8-17 years with asthma. asthma control level was evaluated by asthma control test and physical activity level was evaluated by physical activity questionnaire for children (ipaq-c) and leisure time activity scale.

asthma and obesity, which are important public health problems and are common in childhood, are chronic diseases. the aim of this study was to compare breastfeeding duration, vitamin d intake, asthma control and physical activity levels between obese asthmatic children and non-obese children. the study was a prospective study conducted in children aged 8-17 years with asthma. demographic information of the children was recorded. asthma control level was assessed by asthma control test and physical activity level was assessed by physical activity questionnaire for children (ipaq-c) and leisure time activity scale. it was conducted as a single-blind, prospective study in which the patients were randomized by simple randomization method as obese asthmatic children (experimental group) and non-obese asthmatic children (control group) according to the order of admission to the hospital.

Eligibility criteria:
inclusion criteria: * diagnosed with asthma by a pediatrician, * not in the attack process, * no mental problems, * do not have any systemic disease accompanying asthma (diabetes, etc.) * children who voluntarily agreed to participate in the study exclusion criteria: * severe posture disorders * idiopathic scoliosis and idiopathic rheumatic disease * history of orthopedic surgery * children with mental retardation or a neurological problem

Keywords: childhood asthma obesity physical activity postnatal nutrition
acupuncture for non-cyclical breast pain

Conditions: Breast Pain

Summary: breast pain or mastalgia is a common and troublesome symptom for many women. whereas cyclical breast pain related to hormonal fluctuations can frequently be treated, non-cyclical breast pain can go untreated due to its various etiologies and non-specific presentation. acupuncture is an ancient form of chinese medicine that has been used for centuries to treat a vast array of illnesses and conditions. research has shown that acupuncture has a link to a release of endorphins and other chemicals in the central nervous system. thus, it is thought to help relieve pain. to date, there has been minimal research using acupuncture for breast pain. this pilot of 30 women will seek to determine whether four acupuncture treatments over a period of two weeks will significantly lower the level of pain experienced by these participants. additionally, we will evaluate quality of life measures.


Eligibility criteria:
* female * greater than 18 years * non-cyclical unilateral or bilateral breast pain occurring daily, greater than or equal to 2 on the bpi (average pain question) * pain for more than 3 months * satisfactory (non-suspicious for malignancy) breast examination within one year of enrollment (need documentation from physician or advanced practice nurse) * satisfactory (non-suspicious for malignancy) mammogram and/or ultrasound within one year if greater than 35 years(need written report to verify) * able to return for acupuncture two times a week for two weeks * speak and understand english * hormone replacement therapy discontinued \> 3 months
the effects of an empowerment program for parents of children with autism

Conditions: Autism; Parenting; Motivational Interviewing

Summary: this study aims to evaluate the effectiveness of an empowerment program that includes both parent training and motivational interviewing for parents of children with autism, supporting their competence in the care of their children.

this study was conducted to evaluate the effectiveness of an empowerment program for parents of children with autism to support their competence in caring for their children. this randomized controlled study was conducted in manisa city center/turkey, in 2022. a total of 69 parents (intervention: 34, control: 35) were included in this unblinded, two-group randomized controlled interventional study. a parent empowerment program, including four parental training sessions and two motivational interview sessions, were applied to the parents in the intervention group. the parental self-efficacy scale, zarit care burden scale, perceived stress scale, and family empowerment scale were used to evaluate the effectiveness of the empowerment program.

Eligibility criteria:
inclusion criteria: * inclusion criteria were having a child diagnosed with asd between the ages of 6 and 14, being literate, and volunteering to participate in the study. exclusion criteria: * having a child with a concomitant disability or disease (e.g., epilepsy, attention deficit, and hyperactivity disorder, other physical or mental disabilities), previous participation in an education program with similar content, or parents who did not participate in at least two-thirds of the empowerment training program or did not attend all motivational interview sessions were excluded from the study, and their data were not included in the analysis.

Keywords: autism parent training empowerment parental self-efficacy parental stress care burden