Kornimate/medical-research-clean huggingface dataset:
personalized quantum sonotherapy in regional anesthesia

Conditions: Pain, Postoperative; Anxiety

Summary: the objetive of the study is to evaluate the effect of personalized quantum sonotherapy on the level of anxiety and pain in outpatients schedule for orthopedic surgery under regional anesthesia in a second level center. the investigators believed that personalized quantum sonotherapy could reduce the levels of anxiety and pain before and after surgery evaluated through hemodynamic variables and scales for pain (analogous visual scale) and anxiety (stai spielberger anxious state questionnaire).


Eligibility criteria:
inclusion criteria: * patients scheduled for elective orthopedic ambulatory surgery under regional anesthesia * age between 18 and 60 years. * patients with anesthetic risk asa 1 and 2. * patients without contraindications for the administration of opioids and benzodiazepines. * patients living in the metropolitan area who have a telephone line and can be contacted by telephone within the first 48 hours through calls at 24 and 48 hours after surgery, made by the researchers at the number previously reported by the patient. * patients with an adequate level of understanding, who are able to communicate by telephone and understand a numerical scale. * patients who agree to participate in the work. exclusion criteria: * patients with auditory and cognitive problems. * patients requiring general anesthesia at some time during the intraoperative period. * patients with morbid obesity. * patients consuming anxiolytics in the last month. * patients whose start of surgery is after 45 minutes of the blockade.

Keywords: personalized quantum sonotherapy regional anesthesia peripheral nerve block
no-worry baby project

Conditions: Gestational Diabetes Mellitus in Pregnancy; Gestational Hypertension; Thyroid Disease Pregnancy; Obesity; Anemia in Pregnancy; Complications, Pregnancy; Depression; Obstetric Labor Complications; Asthma; Allergic Disorder; Immune System Diseases; Neurodevelopmental Disorders; Reproductive Disorder

Summary: the huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in huizhou, china.

huizhou mother-infant cohort (no-worry baby project) is a scientific research/public health project jointly initiated by huizhou first maternity and child healthcare hospital and school of public health, sun yat-sen university. the project plans to recruit 10,000 participants since early pregnancy and follow up for three years after birth in the first stage. biological samples, data from questionnaires survey and clinical information will be collected for both mothers and infants. the study is aimed to investigate the effects of dietary factors and environmental exposures during pregnancy on infants' health as well as the prognosis of diseased mothers. the study will have essentially both clinical and public health implications to find effective strategies for prevention and management of a range of chronic disorders (above mentioned) during pregnancy and exploration of the possible impacts on offspring health. the cohort will provide scientific basic for improvement of mother and infant's health.

Eligibility criteria:
inclusion criteria: * pregnant women who have plan to delivery and participate in child care in huizhou hospital; * pregnant women who have resided in huizhou for at least 3 years; * pregnant women who are consent for specimens and data collection and follow-ups for both mother and infant. exclusion criteria: * pregnant women who are with gestational age more than 24 weeks ; * pregnant women who refuse to participate or be unwilling to sign informed consent; * pregnant women who are mentally incapacitated and need guardians.
epidemiological study in frontotemporal dementia

Conditions: Frontotemporal Dementia

Summary: an international, multicenter, epidemiological observational study aims to investigate the prevalence of genetic etiologies in patients diagnosed with ftd or clinically suspected for ftd.

frontotemporal dementia (ftd) is a genetically and pathologically heterogeneous neurodegenerative disease caused by the loss or damage of nerve cells in the brain's frontal and temporal lobes. this leads to abnormalities in behaviour, personality, and language comprehension problems. also, people with ftd show movement disorders like tremor, rigidity, difficulty in coordination, muscle spasms and weakness. ftd's etiology is sporadic or heritable. sixty to 70% of ftd cases are sporadic, while 30 to 40% are inherited (familial aggregation). for this study, blood samples were collected from clinically diagnosed or suspected ftd patients and were analysed for a broad range of pathogenic variants in genes associated with ftd. the scientific insights acquired from this study will help identify novel therapeutic targets and develop/ investigate potential disease-modifying drugs.

Eligibility criteria:
inclusion criteria: * informed consent, which includes reference to the genetic testing, is obtained from the participant/legal guardian * the participant is aged between 25 to 85 years * the participant is diagnosed with frontotemporal dementia (ftd) or has signs or symptoms of ftd
steri-strips for reducing radial artery compression duration

Conditions: Acute Coronary Syndrome

Summary: the duration of radial artery compression with the use of steri-strips may become much shorter than the duration of using the conventional pneumatic tr band alone for achieving hemostasis. consequently, the frequency of radial artery occlusion (rao) will be much lower and post procedure patency of radial artery will be higher along with significant alleviation of pain duration. steri-strips is a kind of sterile adhesive tape used to approximate the clean and superficial wound or surgical incision as an alternate of stitch. its ability to keep the radial puncture site incision approximated will lead to lesser chances of platelet plug disruption or displacement at the entry site and will hasten the process of hemostasis. the use of steri-strips unlikely to have adverse consequences as it is going to be used as an assist to the usual conventional method. in a study conducted by faravash et al. in 2016, showed significant reduction in the area of post-rhinoplasty ecchymosis in lower lid, malar and cheek soft tissues with use of steri-strips with no reported safety concerns. therefore, the aim of this study is to compare duration of radial artery compression by conventional method using the pneumatic tr band alone and with use of surgical steri-strips for achieving hemostasis with patency of radial artery after transradial coronary angiography along with reduction of pain duration due to arterial compression.

study population: patients undergoing coronary angiography through transradial approach. study groups: patients will be randomly assigned in a 1:1 manner to radial arterial compression with conventional pneumatic tr band alone and radial arterial compression with pneumatic tr band mechanical compression with use of clean sterile steri-strips. treatment group. pneumatic tr band compression with use of steri-strips control group. pneumatic tr band compression alone method of radial artery compression after sheath removal: conventional mechanical compression: application of pneumatic tr band alone for 4 hours. mechanical compression with use of steri-strips: after putting adequate manual pressure proximal to radial puncture site, dry and sterile application of steri-strip followed by pneumatic tr band for 1 hour. end points: primary endpoint will be the time duration of achieving hemostasis with radial artery patency secondary endpoint will be hematoma or bleeding

Eligibility criteria:
inclusion criteria: * patients undergoing coronary angiography through transradial approach * either gender with age ≥18 years * positive barbeau test (type a to c) exclusion criteria: * patients refuse to give consent * negative barbeau test (type d) * patients with bleeding diathesis or on oral anticoagulation

Keywords: radial artery tr band steri-strips coronary angiogram radial patency
topo-pachymetric customized accelerated epi-on vs accelerated epi-off corneal cross linking in keratoconus management

Conditions: Amount of Corneal Flattening (Kmax Flattening); Change in the Endothelial Cell Count

Summary: the objective of this study is to compare the clinical effectiveness and safety of topo-pachymetric customized accelerated epithelium-on (acfxl) to standard accelerated epithelium-off (acxl) corneal collagen cross-linking in the management of keratoconus. the study aims to evaluate visual and structural outcomes, to provide valuable insights into optimizing treatment strategies.


Eligibility criteria:
inclusion criteria: 1. age: 18 years or older 2. corrected distance visual acuity (cdva) of ≥ 0.3 snellen. 3. central corneal thickness (de-epithelialized) of ≥ 400 micron. 4. corneal endothelial count of ≥ 2000. exclusion criteria: 1. previous eye surgery 2. the presence of lesions other than keratoconus, central or paracentral scaring 3. history of cross linking 4. history of viral keratitis 5. connective tissue diseases 6. pregnancy or lactation during the study. 7. the presence of nystagmus
iqp-po-101 for the regulation of bowel movement frequency

Conditions: Constipation; Irregular Bowel Movement Frequency

Summary: the purpose of the study is to evaluate the safety and efficacy of iqp-po-101 in regulating the bowel movement frequency


Eligibility criteria:
inclusion criteria: * a subject must have experienced 2 - 4 bowel movements per week and at least 2 of the following symptoms over the preceding 3 months (self-reported): * excessive straining * lumpy or hard stools * sensation of anorectal obstruc-tion * a sense of incomplete evacua-tion of bowel movements * a need for digital manipulation to facilitate evacuation * recorded between 4 and 9 defecations in the 14-day bowel movement diary during the run-in period * subjects of childbearing potential must agree to use appropriate contraceptive methods during run-in and treatment period * commitment to avoid the use of any laxatives and/ or other medicinal products/ supplements that may interfere with bowel movement frequency during the run-in and treatment period * written informed consent. exclusion criteria: * known sensitivity to the ingredients of the device * any organic gastrointestinal diseases, congenital or otherwise * presence of occult blood on screening * constipation that may have been drug-induced * use of any laxative/ products that help ease bowel movements within 7 days of the screening visit * constipation other than idiopathic constipation * presence of other factor(s) that, in the in-vestigator's judgement, should preclude subject participation
esd for the treatment of early barrett's neoplasia

Conditions: Barrett Esophagus; Esophageal Neoplasm

Summary: this study assesses the quality of the resection of early neoplasia arinsing in barrett's esophagus using endoscopic submucosal dissection. it is a multicenter prospective registry among 7 centers including all consecutive patients with early barrett's neoplasia of 15 mm or more in size treated by endoscopic submucosal dissection.

endoscopic submucosal dissection ( esd) demonstrated great efficacy in the treatment of squamous cell carcinoma of the esophagus. results for the treatment of esophageal adenocarcinoma arising in barrett's esophagus are conflicting. in this multicenter prospective registry among 7 french centers, all consecutive patients with early barrett's neoplasia of 15 mm or more in size treated by endoscopic submucosal dissection will be included in the registry. the primary objective is to assess the quality of the resection by esd of early barrett's neoplasia (t1a or t1b sm1 or high grade dysplasia). secondary endpoints are to assess the combined efficacy of a treatment associating esd and radiofrequency ablation of the remaining barrett esophagus, and to assess the durability of the results after 3 years.

Eligibility criteria:
inclusion criteria: * barrett's esophagus at least c0m2 with histological documentation of intestinal metaplasia * visible abnormality of at least 15 mm in size * absence of mediastinal or coeliomesenteric enlarged lymph nodes or muscle layer invasion on pretherapeutic eus * absence of mediastinal or coeliomesenteric enlarged lymph nodes or metastases on pretherapeutic ct scan exclusion criteria: * history of esophageal external irradiation * history of esophagectomy or gastrectomy gastrectomie ou d'oesophagectomie * esophageal stricture * esophageal varices grade 3 or of any grade with signs of recent bleeding

Keywords: barrett esophagus esophageal adenocarcinoma endoscopic submucosal dissection
effects of sleep disruption on drug response

Conditions: Low Back Pain, Recurrent; Healthy

Summary: the central scientific premise of the proposed study is that sleep disruption (sd) will influence individuals' subjective response to blinded medication administration. the investigators further believe these responses will vary among patients who have chronic low back pain (clbp) vs. healthy controls, and that sex will moderate effects. the proposed study evaluates whether clbp patients' subjective responses to study medication administration are altered by sd. the investigators focus on two outcome domains: abuse liability (i.e., drug liking and valuation) and response to pain testing. the investigators propose a mixed between-within randomized crossover human-laboratory experiment that investigates placebo-controlled effects of study medication on 1) abuse liability metrics (drug liking and monetary valuation) and 2) response to laboratory-evoked standardized pain measures, after one night of uninterrupted sleep (us) and again after one night of sd. the investigators will recruit both clbp patients(\*) and healthy controls (n = 60). (\*) we originally aimed to accrue 60 subjects with clbp. however, we have been granted approval by the national institute on drug abuse (nida) to reduce expectations for the target n for the clbp cohort. we are no longer expected to recruit n=60 clbp participants; this is a covid-19 modification, and we are not required to re-do a power analysis.


Eligibility criteria:
inclusion criteria: general inclusion criteria: * 18-60 years old * less than 2 servings/day of caffeinated beverages and willing to discontinue 3 days prior to admission. clbp-specific inclusion criteria: * have a physician-confirmed diagnosis of clbp * report chronic low back pain. exclusion criteria: general exclusion criteria: * bmi \>40 * significant medical or psychiatric morbidity within 6 months or lifetime history of bipolar disorder, psychotic disorder, seizure disorder * lifetime history of opioid use disorder * clinically significant abnormal complete blood count or comprehensive metabolic profile * any contraindicated medical condition (status asthmaticus; chronic obstructive pulmonary disease; reduced respiratory function; hypotension; hypertension; impairment of hepatic, pulmonary or renal functions; myxedema or hyperthyroidism; adrenocortical insufficiency; gastrointestinal obstruction; gall bladder disease; acute alcoholism; history of convulsive disorders; history of head injury) * current use of stimulants, opioids, benzodiazepines or other central nervous system (cns) depressant * positive toxicology screen for opioids, stimulants, or recreational drugs * pregnancy or lactation * significant preadmission psychological distress. healthy control and clbp-specific exclusion criteria: * report current medical/psychiatry history * report acute painful injury (within 3 months) * have a diagnosed chronic pain disorder.
stereotactic ablative radiotherapy in patients with hypertrophic obstructive cardiomyopathy

Conditions: Hypertrophic Obstructive Cardiomyopathy

Summary: hypertrophic obstructive cardiomyopathy (hocm) is an inherited myocardial disease which leads to the muscle in the wall of the heart growing and thickening to the point that it blocks blood flow exiting the heart with increasing risk of sudden cardiac death, heart failure, and atrial fibrillation. surgical septal myectomy and alcohol septal ablation are two invasive therapies for drug-refractory symptomatic patients with hocm. unfortunately, some patients may be unsuitable for both the two procedures. recently, stereotactic ablative radiotherapy, usually used for the treatment of tumours, was confirmed to be feasible, safe and effective in destroying abnormal tissue in heart by targeting high energy heavy ion beams at a specific area of the body precisely. in this study we will determine whether radiation ablation, can be used to destroy the thick heart muscle at the point of obstruction safely and effectively.


Eligibility criteria:
inclusion criteria: * male or female aged ≥ 18 years * drug-refractory symptomatic patients with hocm * willing and able to give written informed consent exclusion criteria: * enrolled in another clinical study. * patient unable to tolerate lying flat for one hour * pregnant or lactating women * with other contraindications for receive stereotactic ablative radiotherapy

Keywords: hypertrophic obstructive cardiomyopathy stereotactic ablative radiotherapy
the management of sportsman's groin hernia in professional and amateur soccer players

Conditions: Sportsman's Groin Hernia

Summary: the purpose of this study is to compare the surgical treatment for sportsman's hernia in our department to the current literature. our hypothesis is that combined solution for the two major problems that cause pain in this syndrome - repair the weakness in the posterior wall of the inguinal canal with "tension free" technique (mesh repair) and reducing the muscle strain on the abdominal wall by cutting, partially, the tendon of the external oblique muscle, will shorten the time to return to full physical activity in soccer players.


Eligibility criteria:
inclusion criteria: * soccer players who reffered to our clinic * soccer players diagnosed with sportsman's hernia * failure of conservative treatment * underwent conventional surgery for sportsman's hernia in our department * completed the follow-up in our clinic * age : 14-40 * male and female exclusion criteria: * soccer players who were diagnosed of had there surgery in other places * soccer players who recover after conservative treatment
ocular inflammation in cataract patients and response to treatment with xiidra

Conditions: Dry Eye

Summary: to determine if the use of xiidra® reduces ocular surface inflammation in preoperative and postoperative cataract patients.

single-center, prospective, randomized, investigator-initiated study 250 cataract patients, aged 60 or older, will be tested for ocular surface inflammation with the inflammadry® immunoassay patients with bilateral positive mmp-9 will be randomized into a group treated with xiidra two weeks preoperatively and six weeks postoperatively or a group not treated with xiidra the investigator hypothesizes that treatment with xiidra prior to routine cataract surgery will significantly improve the quality of keratometry readings and bcva.

Eligibility criteria:
inclusion criteria: * positive for mmp-9 bilaterally as assessed by the inflammadry assay exclusion criteria: * negative inflammadry assay in either eye * active diabetic retinopathy, uncontrolled glaucoma, uncontrolled uveitic inflammation * ocular surface diseases that might confound the interpretation of the inflammadry assay

Keywords: cataract lifitegrast dry eye syndrome ocular surface inflammation hyperosmolarity mmp-9
scan memory program evaluation study

Conditions: Dementia

Summary: the scan memory program evaluation study is an evaluation of a randomized controlled trial intervention consisting of a care management program for cognitively-impaired health plan members and for their informal/family caregivers. the program includes collaboration between the health plan, partnering medical groups, and community organizations. program activities include: 1) telephonic-structured assessments with informal caregivers conducted by scan memory program care managers; 2) problem identification as a result of these assessments; and 3) pre-established protocols and procedures for problem resolution. access, the prototype for the scan memory program, was developed and tested in san diego county and was very successful in helping affected patients and their caregivers.


Eligibility criteria:
inclusion criteria: health plan member eligibility includes having a visit-based icd-9 diagnostic code for dementia or a dementia-specific medication (including donepezil, rivastigmine, galantamine, and memantine) within administrative data any time prior to data inquiry for potential subjects. the health plan member must have a caregiver who can communicate by telephone and though that person might also be a health plan member, health plan membership for caregivers is not required. all subjects must be living in the community and if in a nursing facility, this must be for rehabilitation or respite care but not for long term care. caregivers must be able to communicate in english or spanish. exclusion criteria: person with dementia whose potential participation is declined by their physician. those who do not have a family or informal caregiver cannot participate and caregivers who do no have telephone access or the capacity to consent to research evaluation are excluded. patients who reside in nursing facilities as permanent residents are not eligible. -

Keywords: quality improvement quality of care health care utilization behavioral change
lymphadenectomy for pancreatic head cancer: standard or extended?

Conditions: Pancreatic Ductal Adenocarcinoma

Summary: the purpose of this study is to compare outcomes of patients undergoing standard or extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer


Eligibility criteria:
inclusion criteria: * pathologic diagnosis of pancreatic ductal adenocarcinoma * signed the informed consents exclusion criteria: * pathologic diagnosis of other pancreatic cancers * pre-operative anti-cancer treatment * recurrence patients * patients with contraindication(hepatic/ respiratory/ renal dysfunction, etc ) * pre operative exam: total bilirubin more than 250µmol/l * ajcc stage iv * operation non radical

Keywords: standard lymphadenectomy extended lymphadenectomy pancreaticoduodenectomy
the experiences of patients with greater trochanteric pain syndrome.

Conditions: Greater Trochanteric Pain Syndrome

Summary: greater trochanteric pain syndrome (gtps) is a debilitating condition causing pain on the outside of the hip. this study aims to explore the experiences, beliefs and expectations of patients with gtps, using semi-structured interviews.

greater trochanteric pain syndrome (gtps) is a debilitating condition causing pain on the outside of the hip. there is growing evidence to suggest that psychological barriers to recovery are present in patients with peripheral pain. the experiences and beliefs of patients suffering with gtps are unknown. this study aims to explore the experiences, beliefs and expectations of patients with gtps, using semi-structured interviews to inform the development of interventions for evaluation in future research.

Eligibility criteria:
inclusion criteria: * adults \> 16 * able to speak and understand the english language * patients seen in a specialist consultant lead clinic who have been given the diagnosis of lateral hip pain, greater trochanteric pain syndrome (gtps), trochanteric bursitis or gluteal tendinopathy. exclusion criteria: * inflammatory conditions * systemic / infective disease * previous diagnosis of fibromyalgia or persistent multi-joint pain.

Keywords: gtps gluteal tendinopathy lateral hip pain trochanteric bursitis