Kornimate/medical-research-clean huggingface dataset:
saves-ibd: safety & efficacy of aspirin vs. standard of care for vte prophylaxis after ibd surgery

Conditions: Crohn Disease; Ulcerative Colitis; Venous Thromboembolism

Summary: aim to determine if aspirin 81 mg orally twice daily is effective and safe as an extended vte chemoprophylaxis agent after major abdominal surgery for ibd patients. study will perform an open label trial of aspirin for vte prophylaxis compared standard of care.

patients with inflammatory bowel disease who undergo abdominopelvic intestinal surgery are at increased risk for developing venous thromboembolism, in the form of deep vein thrombosis, pulmonary embolism and mesenteric vein thrombosis for 90-days after surgery. despite being high-risk, the standard of care is to provide mechanical and chemoprophylaxis (unfractionated heparin or low molecular weight heparin) only while they are hospitalized. there exists randomized data, in patients who have had surgery for abdominopelvic cancer, confirming the efficacy of extended post-discharge chemoprophylaxis with either unfractionated heparin or low molecular weight heparin for 28 days after surgery, but no such data exists for ibd. there has been a resistance to adopting this for ibd patients due to compliance and cost of the daily injections. however, recently, a large, multicenter, randomized trial in \>3000 patients who underwent total hip or total knee replacement found that extended aspirin (81 mg) twice daily post-discharge was both equivalent and non-inferior to prophylaxis using full-strength anticoagulation with a factor xa inhibitor. this is a prospective, multicenter, open label clinical trial to assess the safety and efficacy of post-operative venous thromboembolism (vte) prophylaxis with aspirin 81 mg orally twice daily for 30-days after surgery for ibd compared with controls receiving standard of care.

Eligibility criteria:
inclusion criteria: * age \> 18yrs * major abdominopelvic surgery with colon or rectal resection * preoperative diagnosis of crohn's disease, ulcerative colitis, indeterminate colitis * elective surgery * candidate for standard of care vte prophylaxis exclusion criteria: * age \< 100 yrs * aspirin allergy * loop ileostomy closure * emergency surgery * peptic ulcer disease * cirrhosis * bleeding or clotting disorder * thrombocytopenia * chronic renal insufficiency or failure * severe anemia \< 7 preoperatively * need for therapeutic anticoagulation or anti-platelet agents post-operatively including aspirin, warfarin, heparin, clopidogrel, rivaroxaban, others

Keywords: surgery prophylaxis
supraclavicular blocks for post-operative pain control in supracondylar fracture fixation, a retrospective analysis of single shot catheter techniques

Conditions: Acute Pain; Pain, Postoperative

Summary: we hypothesize that patients who receive a supraclavicular block via angiocath, placed intra-operatively and dosed post-operatively following neurologic examination, will have lower pain scores, lower use of intravenous morphine equivalents in the post-anesthesia care unit, and lower rates of intervention for post-operative nausea and vomiting. we also hypothesize that patients receiving this nerve block had the same rates of nerve damage as the patients who did not receive a block and that there will be no demonstrable safety concerns with this block.


Eligibility criteria:
inclusion criteria: * age under 18 * undergoing supracondylar fracture fixation in operating room exclusion criteria: * incomplete or inaccessable chart data

Keywords: supraclavicular block supraclavicular catheter pediatric anesthesia regional anesthesia supracondylar elbow fracture
motor evoked potentials with modified facilitation technique

Conditions: Multiple Sclerosis

Summary: investigating the change in test- retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in patients with multiple sclerosis regarding detection of pathologic results


Eligibility criteria:
inclusion criteria for healthy individuals: * ability to understand the purpose and risks of the study, provide signed and dated informed consent * between 18 and 65 year of age * no neurologic or psychiatric comorbidity requiring continous treatment * no previous damage of central nervous system inclusion criteria for patients: * ability to understand the purpose and risks of the study, provide signed and dated informed consent * between 18 and 65 year of age * patients with inflammatory diseases of the central nervous system (cns) or multiple sclerosis appointed for routine mep diagnostic at the department of clinical neurophysiology, university hospital basel exclusion criteria: * contraindication for measuring of motoric evoked potentials (mep): metal implants (pacemaker, stents); known epilepsy oder previous epileptic fit * known disease of the peripheral nervous system (polyneuropathy)

Keywords: facilitation technique multimodal evoked potentials (mmep) in multiple sclerosis motor evoked potential (mep) in multiple sclerosis
prognostic value of "cd200" in hematological malignancies. hematological malignancies comprise a group of malignant clonal disorders arising from the hematopoietic tissues , including leukemia , multiple myeloma , and they have a high morbidity and mortality

Conditions: Hematological Malignancies

Summary: prognostic value of 'cd200' in hematological malignancies hematological malignancies comprise a group of malignant clonal disorders arising from the hematopoietic tissues , including leukemia , multiple myeloma , and lymphoma , and they have a high morbidity and mortality


Eligibility criteria:
inclusion criteria: * newly diagnosed cases of hematological malignancis. exclusion criteria: * known cases of hematological malignancies and on treatment.
effect of pilates on balance and spinal curvature in upper crossed syndrome

Conditions: Postural; Defect

Summary: the study will be conducted to investigate the effect of pilates exercise on spinal curvature and balance in patients with the upper cross syndrome. .

upper crossed syndrome (ucs) is the most common postural dysfunction in the musculature of the shoulder girdle /cervicothoracic region, which creates joint dysfunction, particularly at the atlanto-occipital joint, cervicothoracic joint c4-c5 segment, glenohumeral joint and t4-t5 segment. pilates is designed as a program that will work with other exercise programs to strengthen, rebalance and realign the body. pilates trains individuals to identify their own musculoskeletal strengths and weaknesses and equips them with the knowledge to correct and rebalance their entire body mechanics (worth,2004) thus, the focus is also placed on improving personal body awareness which further decreases the risks of strain or injury that can occur with imbalances. forty patients with ucs will be allocated randomly into two groups; one experimental group will receive pilates exercise and postural correction twice a week for four weeks, and the control group will receive postural correction exercise along twice a week for four weeks

Eligibility criteria:
inclusion criteria: * the patient's age ranged from 17 to 22 years * body mass index between 20-25 kg/m2 * the participants are diagnosed with upper cross syndrome * patients with normal cognitive aspects willing and able to participate in a program safely exclusion criteria: * the participants have experienced any recent trauma (within 3 months of the initial consultation) * the participant's primary complaint is that of headaches or facial pain. * contra-indications to pilates are found pregnancy, hypertension, osteoporosis, and spinal tumors. * participants have any sort of structural abnormality in upper and middle back e.g., scoliosis, or had a positive adams test. * participants who are taking anti-inflammatory or muscle relaxant medication had to have a three-day "wash out" period before participating in the study

Keywords: pilates exercise upper cross syndrome balance spinal curvature
study of norepinephrine levels and sympathetic nervous system activity

Conditions: Autonomic Nervous System Disease; Healthy; Hypertension

Summary: brain and nerve cells communicate with each other by releasing and picking up chemicals called neurotransmitters. norepinephrine is a neurotransmitter used by part of the nervous system activated during stress called the sympathetic nervous system. the sympathetic nervous system is involved with regulating blood pressure and pulse rate. researchers believe the level norepinephrine in the blood can be used to measure activity of the sympathetic nervous system. this study is designed to answer important questions about rates of release of norepinephrine into the blood stream, removal of released norepinephrine, and the sympathetic nervous system response to stress. researchers will attempt to measure levels of norepinephrine and activity of the sympathetic nervous system in patients with high blood pressure, normal patients with family histories of high blood pressure, patients taking drugs that can effect levels of norepinephrine, and patients with diseases or conditions directly affecting the sympathetic nervous system.

in order to examine sympathetic nervous system function in neurocardiological disorders and catecholaminergic effects of dietary manipulations or neuropsychiatric drugs, the protocol calls for evaluations of the kinetics of 3h-norepinephrine or 3h-epinephrine in patients with hypertension, dysautonomias, or disorders thought to involve abnormal catecholaminergic function, and in normotensive normal volunteers. apparent spillover and clearance rates are estimated based on the norepinephrine or epinephrine concentration during the infusion and their steady-state specific activities, under resting conditions and in response to physiological or pharmacological manipulations thought to affect sympathetic outflows.

Eligibility criteria:
must be greater than or equal to 18 years of age. must not be pregnant or lactating.

Keywords: yohimbine catecholamines sympathoadrenal response sympathetic nervous system stress hypertension autonomic failure
a controlled study of community-based exercise training in patients with moderate copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the effectiveness of clinic-based pulmonary rehabilitation in advanced chronic obstructive pulmonary disease (copd) is well established, but few data exist for less severe patients treated in alternative settings. the purpose of this study was to investigate whether a novel, community-based exercise program was feasible and effective for patients with moderate copd.


Eligibility criteria:
inclusion criteria: * patients with moderate copd and self-reported exercise impairment exclusion criteria: * current smokers, pulmonary diseases other than copd, use of supplemental oxygen, musculoskeletal disease that impaired exercise performance and unstable coronary artery disease or congestive heart failure
falls prevention for visually impaired older people

Conditions: Accidental Fall; Visual Impairment; Fall

Summary: this study aims to examine the effectiveness of an intensive five day falls prevention training programme with a home evaluation and a home exercise programme, compared with a home evaluation and exercise programme alone for reducing incidence of falls and fear of falling, and improving confidence in functional ability and objective balance.

while previous research shows a clear link between visual impairment and increased risk and incidence of falls, as well as fear of falling, there is little research to investigate the effectiveness of falls prevention programmes for visually impaired populations. at the time of writing there were no studies identified that used this type of intensive training over a period of several days, rather most of the studies that exist have been conducted in community settings. this study will aim to compare the effectiveness of a comprehensive exercise programme aimed at improving balance, walking technique, postural control and ability to complete functional tasks, with a home exercise programme with either written or audio instructions.

Eligibility criteria:
inclusion criteria: * participant is able to mobilise with or without walking aids or hand-hold * participant has history of falls * any possible medical or pharmaceutical causes of falls have been investigated and excluded * participant has a diagnosed visual impairment * participant is aged 65 or over * participant's falls can not be attributed purely to their visual impairment * participant is a member of blind veterans uk * participant is physically able to take part in group and individual exercise sessions * participant is able to understand and follow verbal and/or written instructions exclusion criteria: * participant is under 65 years of age * participant is medically unwell or has a medical condition for which exercise is contraindicated * participant is currently involved in other falls prevention programmes * participant is predominantly a wheelchair user * participant is unable to understand or follow instruction from staff in english
endoscopic dacryocystorhinostomy prospective research

Conditions: Lacrimal Duct Obstruction

Summary: endoscopic dacryocystorhinostomy (en-dcr) is an effective procedure when treating saccal and postsaccal obstructions of the nasolacrimal pathway. the benefit of silicone tubing after dcr is still controversial. we conducted a prospective, randomized study in order to evaluate 1) the necessity of bicanalicular silicone tubes after primary en-dcr, 2) efficacy of the perioperative mitomycin c for the prevention of adheesion and re-stenosis of rhinostomy site in revision en-dcr, 3) the subjective symptoms and qol changes before and after dcr-operation.


Eligibility criteria:
inclusion criteria: * adults (age \> 18), asai-iii, and were scheduled for primary or revision lacrimal pathway surgery due to recurrent or chronic watering eyes or conjunctival discharge. * patients were excluded if they had previous nasolacrimal surgery, malignancy in the paranasal sinuses, nasal cavity, or lacrimal pathway, presaccal obstruction, pregnancy or lactation, or mental disability. exclusion criteria: * malignancy in the paranasal sinuses, nasal cavity, or lacrimal pathway, presaccal obstruction, pregnancy or lactation, or mental disability.

Keywords: primary,silicone tube,revision,mitomycin c,endoscopic dcr
feasibility study of a computerized cognitive stimulation

Conditions: Mild Cognitive Impairment, So Stated

Summary: this non-pharmacological interventional feasibility study evaluate a computerized cognitive stimulation program in elderly with mild cognitive impairment.

involvement in social and leisure activities has been associated with a decreased risk of dementia in the elderly with mild cognitive impairment (mci). mci is a crucial phase to prevent the worsening of cognitive decline in elderly at risk to develop dementia. these last years, the use of computerized training programs to enhance cognitive functioning showed positive and promising results. however, the effects on psychosocial factors still poorly documented in cognitive interventions in mci. it seems essential to promote these factors involving social ties, group dynamic, the motivation, as factors that can contribute to enhance social life and cognitive functioning. this feasibility study evaluated a computer-based cognitive stimulation in elderly with mci and explore the effects on cognitive and psychosocial components.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild cognitive impairment * absence of history of alcohol or other substance consumption * no engagement in other cognitive intervention program exclusion criteria: * psychiatric and neurological disorders * conversion toward dementia during intervention * sensory and or motor deficit that could interfere with the use of computer tool

Keywords: mild cognitive impairment computerized cognitive stimulation cognition psychosocial factors
safety, pharmacokinetics, bioavailability, food effect, drug-drug interaction study of apx001 administered orally

Conditions: Fungal Infection

Summary: this is a phase l double-blind, placebo-controlled, randomized study to investigate the safety, tolerability, pharmacokinetics, bioavailability and food effect of single doses of apx001 administered intravenously and orally, followed by an evaluation of the safety, tolerability, pharmacokinetics and drug-drug interaction potential of multiple doses of apx001 administered orally.


Eligibility criteria:
inclusion criteria: * women of childbearing potential must agree to avoid pregnancy during the study and to use contraception at least 2 weeks before the start of the study until 3 months after the last dose of study drug. * males with partner(s) of childbearing potential must agree to use appropriate barrier contraception from the screening period until 3 months after the last dose of study drug. * screening hematology, clinical chemistry, coagulation and urinalysis consistent with overall good health. * no significantly abnormal findings on physical examination, ecg and vital signs. * willing and able to provide written informed consent. exclusion criteria: * any uncontrolled or active major systemic disease including, but not limited to: cardiovascular, pulmonary, gastrointestinal, metabolic, urogenital, neurological, immunological, psychiatric, or neoplastic disorder with metastatic potential. * history or presence of malignancy within the past year. subjects who have been successfully treated with no recurrence of basal cell carcinoma of the skin or carcinoma in-situ of the cervix may be enrolled. * use of prescription medication within 14 days prior to the first dose of study drug and throughout the study. * use of non-prescription or over-the-counter medications within 7 days prior to the first dose of study drug and throughout the study. * positive results on any of the following screening laboratory tests: serum pregnancy test, urine alcohol test, urine drugs of abuse, hepatitis b surface antigen, hepatitis c antibody, and human immunodeficiency virus (hiv) antibody.
improving medical decision making for older patients with end stage renal disease

Conditions: Renal Disease, End Stage; Palliative Care; Decision Aids

Summary: the overall objective of this study is to reduce the burden of chronic kidney disease (ckd) and its consequences for an aging u.s. population. to accomplish this, the investigators propose to conduct a multi-center randomized trial of an advance care planning (acp) video intervention (vs. usual care) among older patients with ckd.

the video intervention consists of a video decision aid along with a video declaration (videc), which is recorded by the patient. the video decision aid explores acp options for medical care for end-stage renal disease (esrd) and reviews hemodialysis, peritoneal dialysis, as well as medical management without dialysis; it also reviews cardiopulmonary resuscitation (cpr). patients will also audio- or video-record their preferences using a tablet. the video will be shared with their nephrologist. the patient will have a copy of the video to take with them and share with their loved ones. patients will answer survey questions about their preferences, knowledge, decisional conflict, and acp engagement. they will be surveyed every two months for one year or death (if they die before one year). potential participants will be recruited from 10 nephrology clinics: massachusetts general hospital (n=75), brigham and women's hospital (n=75), university of pittsburgh (n=75), university of pennsylvania, stanford university, palo alto veterans institute for research, university of washington, renal \& transplant associates of new england, university of new mexico and boston medical center.

Eligibility criteria:
inclusion criteria: * patients age ≥70 are eligible if they have either advanced ckd defined as one egfr value ≤ 30 ml/min/1.73m2 in the past 12 months not determined to be a result of aki or have a diagnosis of ckd and less than a two-year prognosis from any cause, defined by the clinician answering "no" to the surprise question ("would you be surprised if this patients died in the next two years?") * patients age 65-69 are eligible if they have both advanced ckd defined as one egfr value ≤ 30 ml/min/1.73m2 not determined to be a result of aki and have less than a two-year prognosis, defined by the clinician answering "no" to the surprise question ("would you be surprised if this patients died in the next two years?") * patients who have not had a nephrology visit in the past 12 months can be recruited from non-nephrology clinics per the above eligibility criteria exclusion criteria: * listed for kidney transplantation or previous transplant recipient * already on or previously on dialysis (including emergent dialysis) * new patient visit * visually impaired beyond 20/200 corrected * psychological state not appropriate for acp discussions as determined by the primary nephrologist * cognitive impairment

Keywords: video decision aid video declaration aging population
thrombin generation assay to assess thrombotic risk in nephrotic patients

Conditions: Nephrotic Syndrome

Summary: the thromboembolic risk is increased during the nephrotic syndrome (ns) with an incidence of deep vein thrombosis 15%, pulmonary embolism of 10-30% and renal vein thrombosis of 25-37%. there is a hemostatic imbalance with urinary leakage of anticoagulant factors and increased hepatic synthesis of procoagulant factors, platelet hyperaggregability and a decrease in fibrinolytic activity. however, the identification of patients requiring anticoagulant prophylaxis remains imprecise.the thromboembolic risk is higher when the ns is related to extramembranous glomerulonephritis comparatively to others glomerulopathies. the reason of this difference is not still known. this risk increase with sn's severity and therefore with the decrease of albuminemia. moreover, few studies have evaluated anticoagulant treatment efficacy during a ns, which clinical benefit depends also on hemorrhagic risk specific of each patient. thus, the determination of the thrombotic risk and the modalities of anticoagulation are variable and perfectible during the ns. we propose to use the thrombin generation test (tgt) to quantify the thromboembolic risk in patients with a ns and to follow its evolution during prophylactic anticoagulation and after remission of ns.

thrombin generation test will be performed prospectively in nephrotic patients with various diseases (minimal change disease (mcd), malignant nephrosclerosis (mn), focal segmental glomerulosclerosis (fsgs), diabetic glomerulopathy...) at diagnosis, during anticoagulant treatment (d8±3) and after disease remission (m6).

Eligibility criteria:
inclusion criteria: * nephrotic syndrome * known cause of nephrotic syndrome (renal biopsy and/or positive anti-pla2r) exclusion criteria: - active anticoagulation treatment before tgt

Keywords: nephrotic syndrome thrombotic risk assessment
a research study of how a new medicine called amycretin, given as tablets, works in japanese men with obesity

Conditions: Obesity

Summary: the purpose of the study is to evaluate if a new study drug, nnc0487-0111, is safe and how it works in the participant's body, when given as an oral tablet to japanese participants.


Eligibility criteria:
key inclusion criteria * male with both parents of japanese descent * body mass index (bmi) between 25.0 and 34.9 kg/m\^2 (both inclusive). body weight equal to or greater than 65.0 kg * considered eligible based on the medical history, physical examination, and the results of vital signs, electrocardiogram (ecg) and clinical laboratory tests performed during the screening visit, as judged by the investigator key exclusion criteria * any disorder that in the investigator's opinion might jeopardise participant's safety or compliance with the protocol * presence of clinically significant gastrointestinal disorders or symptoms of gastrointestinal disorders potentially affecting absorption of drugs or nutrients, or as judged by the investigator