Kornimate/medical-research-clean huggingface dataset:
quality of life and survivorship care in patients undergoing hyperthermic intraperitoneal chemotherapy (hipec)

Conditions: Advanced Malignant Mesothelioma; Carcinoma of the Appendix; Ovarian Sarcoma; Ovarian Stromal Cancer; Pseudomyxoma Peritonei; Recurrent Colon Cancer; Recurrent Malignant Mesothelioma; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Stage III Colon Cancer; Stage III Ovarian Epithelial Cancer; Stage III Ovarian Germ Cell Tumor; Stage IV Colon Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Unspecified Childhood Solid Tumor, Protocol Specific

Summary: rationale: an orientation and patient education program and telephone counseling may help improve the quality of life in patients with peritoneal surface malignancies. purpose: this clinical trial studies quality of life and survivorship care in patients undergoing surgery and chemotherapy for peritoneal surface malignancies.

primary objectives: i. assess feasibility of instituting an orientation program, brief follow up care and phone calls in this patient population. secondary objectives: i. reduce pre-treatment distress and anxiety. ii. improve pre-treatment self-efficacy. iii. provide educational material delivered by the srb. iv. improve overall post-operative qol ratings at 3 months, relative to discharge. outline: patients and their caregiver(s) receive a hyperthermic intraperitoneal chemotherapy (hipec) orientation with a survivorship navigator (sn) over 90 minutes following their initial surgical consult. patients then receive telephone calls over 20-30 minutes from the sn once weekly for 3 weeks prior to hipec. . after hipec, patients meet with the sn for 20-30 minutes to discuss adjustments and adaptation to the surgery and hospitalization 3-4 days post-hipec, biweekly for two weeks, and weekly thereafter until hospital discharge. after hospital discharge, patients receive telephone calls from the sn twice monthly for 1 month.

Eligibility criteria:
inclusion * patients who undergo cs and hipec for peritoneal surface malignancy
phase iii randomized, double-blind study of prednisone for duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy

Summary: objectives: i. characterize the effect of prednisone on muscle protein metabolism in patients with duchenne muscular dystrophy. ii. determine whether prednisone changes levels of insulin-like growth factor 1, growth hormone, and insulin. iii. characterize the effect of prednisone on muscle morphometry and muscle localization of utrophin. iv. compare the prednisone response in patients with duchenne muscular dystrophy to that seen in normal individuals and in patients with facioscapulohumeral dystrophy.

protocol outline: this is a randomized, double-blind study. patients are randomly assigned to prednisone or placebo. therapy is administered daily for 12 weeks; prednisone is then tapered.

Eligibility criteria:
protocol entry criteria: * ambulatory males with duchenne muscular dystrophy * no medical/psychiatric contraindication to protocol therapy * no requirement for regular use of prescription medication

Keywords: duchenne muscular dystrophy genetic diseases and dysmorphic syndromes muscular dystrophy neurologic and psychiatric disorders rare disease
evaluating the efficiency of newly designed prefabricated pmma crowns for restoring primary teeth in comparison to stainless steel and zirconia crowns

Conditions: Decay, Dental

Summary: evaluation of pmma pediatric crowns

the aim of the present study is to evaluate the pmma crowns regarding the following aspects: i. clinical evaluation of pmma crowns regarding wear of opposing teeth when compared to zirconia crowns and stainless steel crowns after 6 months, and 12 months. ii. color stability of pmma crowns and zirconia crowns after 6 months, and 12 months. iii. gingival health of restored teeth after 6 months, and 12 months. iv. patient's satisfaction regarding the appearance and clinical performance of pmma crowns when compared to stainless steel crowns and zirconia crowns through a given questionnaire.

Eligibility criteria:
inclusion criteria: * children included in the study should conform to the following criteria: 1. aged 5-8 years old 2. medically free 3. patient should suffer from extensively decayed primary lower second molar that will undergo pulpotomy. 4. the anticipated exfoliation date of the selected primary teeth has to be more than 12 months from the date of the study start. exclusion criteria: children with the following criteria will be totally excluded from the study: 1. children who are extremely uncooperative and difficult to manage. 2. children suffering from any medical conditions that can't be managed in the clinic. 3. teeth with decay extending beneath the free gingival margin. 4. teeth that were grossly broken down, that cannot be restored. 5. presence of uncontrolled bleeding. 6. clinical or radiographic evidence of non-vitality such as presence of an abscess or a sinus, obvious discoloration, and premature hypermobility.
effect of african leafy vegetables on nutritional status of south african school children.

Conditions: Iron Status; Vitamin A Status; Zinc Status; Malnutrition

Summary: the combination of poverty-related infectious and lifestyle-related non-communicable diseases, both driven by malnutrition, causes a high burden for south africa. healthy and nutritious diets for populations depend on availability and accessibility of a variety of plant and animal foods, within a context that promotes and supports healthy behaviour. food based strategies, such as supplementation, food fortification, and diversification of crops, are used to achieve optimal dietary requirements to combat malnutrition, including micronutrient deficiencies. a more sustainable food based strategy is the (promotion of) use of indigenous and traditional foods, such as african leafy vegetables (alvs). unfortunately, several studies from all over africa have shown that there is a shift from traditional diets as result of the preparing techniques and the absence of women in homes. furthermore, indigenous and traditional foods are considered as "poor people's food". against this background, a joint project between south africa, kenya and benin is designed to fill the gaps in knowledge in these countries regarding the availability, acceptability and consumption and evidenced based benefits of foods from local biodiversity. the main aim of the study in south africa is to provide empirical evidence of how the role of biodiversity can be translated into improved health status in contemporary poor rural and urban communities in the north west province of south africa. in order to achieve this it is important to gain knowledge on the possibility of using alvs as a strategy to alleviate micronutrient deficiencies. therefore an intervention study to determine the effect of selected alv on the nutritional status (including zinc, iron, and vitamin a status) of school children (grade r-4) residing in contemporary poor rural community in the north west province, south africa has been designed.


Eligibility criteria:
inclusion criteria: * apparently healthy and had no signs and symptoms of acute illness at the time of baseline blood collection * attending grade r - 4 of one of the selected schools exclusion criteria: * children with a haemoglobin concentration \<8 g/dl were excluded from the study and referred for medical treatment. * children who received micronutrient supplements were also excluded from the study.
tailored interactive intervention to increase crcs

Conditions: Colorectal Cancer Screening

Summary: the primary goal of this research project is to conduct a 5-year prospective randomized trial of a theory-based intervention to increase patient completion of colorectal cancer screening (crcs) among patients ages 50 to 64 years old.

specific aim 1: identify behavioral, social, and environmental factors associated with crcs in male and female patients ages 50 to 64 years old in a primary care practice in houston, texas. 1.1. update literature reviews of crcs adherence. 1.2. conduct secondary analysis of relevant data from other projects. 1.3. conduct focus groups with primary care patients to determine their knowledge, attitudes, and beliefs about crcs and to gather data to use for development of the educational intervention. specific aim 2: develop a personal computer (pc)-based tailored interactive intervention based on the transtheoretical (stages of change) model to increase crcs in accordance with american cancer society (acs) crcs guidelines. specific aim 3: evaluate the effectiveness of the pc-based tailored interactive intervention for increasing crcs through a randomized controlled trial. specific aim 4: analyze the relationship between a number of predictor variables and crcs completion in order to develop a more complete conceptual framework for understanding screening adherence. specific aim 5: conduct a cost-effectiveness analysis of the pc-based tailored interactive intervention for increasing crcs in a primary care setting.

Eligibility criteria:
inclusion criteria: * receive primary care at the ksc main campus in houston, texas. * must have been patients at ksc for at least one year prior to enrollment in the study * be 50 to 64 years of age * have had crc or adenomatous polyps * must agree to schedule a routine physical examination with their primary care provider and to complete a baseline interview exclusion criteria: -have never been screened or be due for crcs according to the acs guidelines

Keywords: colorectal cancer screening computer interactive intervention predictors cost effective analysis transtheoretical model
to evaluate the effect on post-prandial glycemia safety, and tolerability of viaject 7 vs. lispro insulin during subcutaneous insulin pump therapy

Conditions: Type 1 Diabetes Mellitus

Summary: the purpose of this study is to evaluate the effect on post-prandial glycemia safety, and tolerability of viaject 7 vs. lispro insulin during sc insulin pump therapy.


Eligibility criteria:
inclusion criteria: 1. males or females diagnosed with type 1 diabetes mellitus for at least 6 months 2. current usage of subcutaneous insulin pump treatment with one of the following pumps: * medtronic paradigm® * animas® * omnipod® * accu-chek spirit® 3. age 18-75 years 4. hba1c of 6.0 - 9.0% at screening visit. 5. willingness to attend 9 clinic visits. exclusion criteria: 1. pregnancy or lactation 2. renal insufficiency (serum creatinine of 2.0 mg/dl or greater). 3. anemia 4. congestive heart failure. 5. visual impairment preventing reading of glucose meter values or the ability to use an insulin pump or continuous glucose monitoring device. 6. active coronary artery disease or heart procedure within the past 4 months. 7. active foot ulceration. 8. severe peripheral arterial disease. 9. stroke within the past 6 months. 10. active alcohol abuse, substance abuse, or severe mental illness. 11. active cancer, except basal cell or squamous cell skin cancers. 12. major surgical operation within 30 days prior to screening. 13. seizure disorder (epilepsy). 14. any concurrent illness, other than diabetes, that is not controlled by a stable therapeutic regimen. 15. currently use of corticosteroids. 16. history of major non-compliance. 17. use of an investigational drug within 30 days prior to screening. 18. bleeding disorder, treatment with warfarin, or low platelet count. 19. any insulin allergy 20. current complaints of major infusion site problems with commercially- available insulin preparations, such as frequent occurrence of infections, marked swelling or marked erythema. 21. history of gastroparesis.
a study to compare bms-936558 to the physician's choice of either dacarbazine or carboplatin and paclitaxel in advanced melanoma patients that have progressed following anti-ctla-4 therapy (checkmate 037)

Conditions: Unresectable or Metastatic Melanoma

Summary: the purpose of the study is to estimate the response rate and compare overall survival of patients taking bms-936558 to those taking study physician's choice of either dacarbazine or carboplatin and paclitaxel


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * men \& women ≥ 18 years of age * eastern cooperative oncology group (ecog) performance status (ps) 0-1 * histologically confirmed stage iii (unresectable)/stage iv melanoma * measurable disease by computed tomography (ct)/magnetic resonance imaging (mri) per response evaluation criteria in solid tumors (recist) 1.1 criteria * objective evidence of disease progression (clinical or radiological) during or after at least 1 (v600 wildtype) or at least 2 (v600 mutation positive) prior treatment regimens * pre-treatment fresh core, excision or punch tumor biopsy * archival formalin-fixed paraffin-embedded (ffpe) tumor material if available exclusion criteria: * any treatment in a bms-936558 (nivolumab) trial * subjects with condition requiring systemic treatment with either corticosteroids (\> 10mg daily prednisone/equivalent) or other immunosuppressive medications within 14 days of study drug administration * active, known or suspected autoimmune disease * unknown braf status * active brain metastasis or leptomeningeal metastasis * ocular melanoma * prior therapy with anti programmed death-1 (anti-pd-1), anti programmed death-ligand 1 (anti-pd-l1) or anti-programmed death-ligand 2 (anti-pd-l2)
oral gabapentin versus placebo for treatment of postoperative pain following photorefractive keratectomy

Conditions: Postoperative Pain

Summary: the purpose of this study is to determine the effectiveness of an oral medication called gabapentin in reducing pain after photorefractive keratectomy (prk) eye surgery and to assess the frequency of use of rescue medication interventions, defined as non-steroidal anti-inflammatory (nsaid) eye drops and oral narcotic medication.


Eligibility criteria:
inclusion criteria: * ability to understand and provide informed consent to participate in this study and complete follow-up visits. * planned photorefractive keratectomy (prk) at the wramc center for refractive surgery. * male or female, of any race, and at least 21 years old at the time of the pre-operative examination, and have signed an informed consent. the lower age limit of 21 years is intended to ensure documentation of refractive stability. * access to transportation to meet follow-up requirements. exclusion criteria: * any reason to be excluded for prk. * female subjects who are pregnant, breast feeding or intend to become pregnant during the study. female subjects will be given a urine pregnancy test prior to participating in the study to rule out pregnancy. \[pregnancy and breastfeeding are contraindications to refractive surgery in general, including prk, whether participating in this study or not\]. * patients with known allergy, sensitivity or inappropriate responsiveness to gabapentin or any of the medications used in the post-operative course. * patients with known depressed renal function. * any physical or mental impairment that would preclude participation in any of the examinations.

Keywords: gabapentin prk pain
bacterial assessment of middle ear fluid in children undergoing ventilation tube placement surgery

Conditions: Chronic Otitis Media; Age Determined Bacteria

Summary: children with chronic otitis media have more resistant bacteria that require surgical intervention to eradicate the infections. the study will evaluate the dominant bacteria and their sensitivities to antibiotics. the information will assist in better treatment plans for children with chronic infections. the data will also assess the changing patterns in the bacteria colonizing middle ear fluid.

ibid.

Eligibility criteria:
inclusion criteria: * all children with chronic ear infections scheduled for surgical interventions exclusion criteria: * children who have undergone prior mastoid surgery, or children with oncologic treatments.

Keywords: ear infection chronic
human testing of an over-the-counter (otc) cream in children with eczema

Conditions: Atopic Dermatitis

Summary: this three week study will be conducted to determine the safety and efficacy of an over-the-counter (otc) cream in children with mild to moderate atopic dermatitis.

the objective of this trial is to evaluate the efficacy and safety of an otc colloidal oatmeal skin protectant cream in children with mild to moderate ad in comparison to that of epiceram®

Eligibility criteria:
inclusion criteria: * children ages 6 mo- 18 years * any ethnicity * diagnosed with atopic dermatitis (ad) per hanifin-rajka criteria * mild to moderate atopic dermatitis per rajka-langeland severity index * willing to use only provided cream and body wash for duration of study exclusion criteria: * known sensitivity to investigational products * pregnant or breastfeeding * severe ad per rajka-langeland severity index * ad requiring class i (super potent) or class ii or iii (potent) topical steroids * requires greater than 2.0 g inhaled or intranasal corticosteroids * other skin conditions which may interfere with the scoring of ad

Keywords: eczema
effect of exercise programs on 3-dimensional scapular kinematics, disability and pain

Conditions: Shoulder Impingement Syndrome

Summary: the aim of this study is to investigate the effect of exercise program on 3-dimensional scapular kinematics, disability and pain on shoulder impingement with scapular dyskinesia.


Eligibility criteria:
inclusion criteria: * subacromial impingement with scapular dyskinesia exclusion criteria: * additional muscular and skeletal or systemic diseases

Keywords: exercise kinematics
use of complementary and alternative medicine among older mexican americans

Conditions: Arthritis; Diabetes Mellitus; Fractures; Hypertension; Depression; Urinary Incontinence

Summary: the purpose of this study is to examine complementary and alternative medicine use among older mexican americans and to determine how this use influences physical, functional, and mental health.

alternative medicine has received increasing attention from both the scientific and public communities. while the majority of current alternative medicine use is the result of interest in replacing or augmenting formal medical treatments, several cultures have long-standing traditions of herbal medicine use, particularly among older, more traditional members. research in this area has been limited primarily to small-scale studies that identify herbal remedies popular in specific cultures. this study observes older mexican americans because a substantial proportion of this population continue to utilize traditional herbal remedies in their everyday life.

Eligibility criteria:
inclusion criteria: * mexican american exclusion criteria: * unable to complete survey questionnaire

Keywords: aged mexican americans complementary therapies
correlation between montreal cognitive assessment and voice therapy outcomes in the aging treatment- seeking population

Conditions: Cognitive Impairment; Voice Disorders; Voicebox Disorders; Cognitive Decline; Swallowing Disorder

Summary: this study will investigate if the performance on the montreal cognitive assessment (moca) is associated or predictive of the outcomes in voice, swallowing or upper airway therapy in the older laryngology treatment seeking patients. the relationship between the scores of moca and parameters in therapy will be analyzed. the outcomes of this study could potentially impact how investigators determine candidacy for therapy and develop patient treatment plans to meet their needs. this is a collaborative study with emory voice center and the nyu voice center.


Eligibility criteria:
inclusion criteria: * 60 years or older with voice/swallowing/upper airway complaints * multidisciplinary assessment by fellowship-trained laryngologist and voice/swallow/upper airway specialized speech-language pathologist * voice, swallowing and/or upper airway disorder diagnosis * candidate for voice, swallowing or upper airway therapy following interdisciplinary assessment. * state willingness to participate in the study protocol exclusion criteria: * under the age of 60 years old * previously diagnosed dementia * central neurological disorder * active psychotic disorder * recurrent or active major depressive disorder (phq-9 of 10 or greater) * patient not able to attempt the moca because of a severe hearing or visual impairment * patients who do not speak or understand english * tested with moca in the last month

Keywords: voice therapy cough therapy swallowing therapy
vertebral fracture treatment comparisons in osteoporotic women

Conditions: Postmenopausal Osteoporosis

Summary: the primary purpose of participation in this study is to answer whether teriparatide is superior to risedronate in reducing the occurrence of new vertebral fractures during 24 months of therapy.


Eligibility criteria:
inclusion criteria: * postmenopausal women with osteoporosis, as defined by low bone mineral density (bmd), i.e. anterior-posterior lumbar spine, total hip or femoral neck bmd ≥1.5 standard deviations below the average bmd for young, healthy, non-hispanic, caucasian women * a minimum of 2 moderate or 1 severe vertebral fragility fractures (confirmed by central reader) were required exclusion criteria: * increased risk of osteosarcoma * history of unresolved skeletal diseases that affect bone metabolism * history of atypical subtrochanteric or diaphyseal femoral fractures * abnormally high or low calcium levels * abnormally high parathyroid hormone (pth) levels * severe vitamin d deficiency * abnormal thyroid function not corrected by therapy * history of malignant neoplasms in the last 5 years * active liver disease, clinical jaundice * significant impairment of hepatic or renal function * history of nephro- or urolithiasis * previous or planned kypho- or vertebroplasty * active or risk for osteonecrosis of the jaw * active or recent history of upper gastrointestinal disorders * unable to stand or sit in the upright position for at least 30 minutes

Keywords: bone loss vertebral fractures
effects on recovery of postoperative gastrointestinal function with multimodal analgesia

Conditions: Gastrointestinal Recovery

Summary: breast cancer surgery is associated with a high incidence of persistant postsurgical pain (ppsp). the aim of the study was to evluate the impact of intravenous tenoxicam on acute and ppsp, analgesic requirements and gastrointestinal recovery in patients undergoing surgery for breast cancer.

thrity patients participated in this randomized, single-blined study. before and at the postoperative day 1, the bowel function (orocecal transmit time) were measured. before induction of general anesthesia, patients recieved a bolus of intravenous tenoxicam or an equal volume of saline (control group). pain score and opioid consumption were recorded in the postoperative period and then daily for 1 week.

Eligibility criteria:
inclusion criteria: * asa i to ii breast cancer patients mastectomy or wide local excision + axillary note dissection exclusion criteria: * preexisting malignancy chronic infection previous pain condition diabetes thyroid disorder severe cardiac, renal or hepatic disease previous breast surgery psychiatric illness neurological disease contraindication for tenoxicam or morphine use

Keywords: orocecal transmit time, flatus