Kornimate/medical-research-clean huggingface dataset:
treatment of intravenous infusion plasma in amyotrophic lateral sclerosis

Conditions: Amyotrophic Lateral Sclerosis

Summary: to evaluate the safety and effectiveness of intravenous infusion of plasma from healthy young people for the treatment of amyotrophic lateral sclerosis.

this is a single-center, open-label clinical study to evaluate the safety and effectiveness of intravenous infusion of plasma from healthy young people for the treatment of amyotrophic lateral sclerosis. the main outcome indicators are the record of adverse reactions and the rate of change of amyotrophic lateral sclerosisfunctional rating scale score. the secondary outcome indicators include survival time-time to the end event (death, tracheotomy, continuous ventilator dependence), forced vital capacity (fvc), recognition knowledge function evaluation (ecas score).

Eligibility criteria:
inclusion criteria: * meet the following diagnosis standard: confirmed, proposed and laboratory supported diagnosis; * age 50-70 years old ; * 3-18 months course of disease; * forced vital capacity (fvc) ≥70% predicted value; * total amyotrophic lateral sclerosis functional rating scale score ≥36, scores of respiratory related items ≥10; * take riluzole regularly before participate in this trial (25\~50mg twice a day for at least 30 days continuously) without obvious side effects and can continue to take for 22 months; * participants of childbearing age take reasonable and effective contraceptive measures from the time of enrollment to the end of follow-up; * signed informed consent. exclusion criteria: * familial amyotrophic lateral sclerosis; * female during pregnancy and lactation; * positive hepatitis b, hepatitis c or hiv in screening * history of cytomegalovirus and malaria infection; * after tracheotomy and ventilator-dependent state (daily use of non-invasive ventilator ≥ 22 hours for 7 consecutive days); * after percutaneous gastrostomy (peg) operation; * has had allergic reactions and other adverse reactions during blood transfusion; * have diseases of the blood system (including immunoglobulin a deficiency); * alanine transaminase, aspartate transaminase≥ 3 times the upper limit of normal; * abnormal renal function (cr, bun); * history of malignant tumors; * combining severe cardiopulmonary diseases, autoimmune diseases, mental diseases, substance abuse history, etc; * currently participating in other clinical studies or using other drugs in researching.

Keywords: amyotrophic lateral sclerosis; plasma infusion
failure of vaginal delivery after induction

Conditions: Labor Pain

Summary: the study will compare the number of women who deliver vaginally after artificial initiation of labor pains(i.e. induction of labor) by two methods. half of the women would receive tablet misoprostol vaginally and the other half would receive tablet misoprostol and foley's balloon catheter both.

artificial initiation of labor pains has become a common occurrence. a variety of methods are employed to initiate labor pains. labor pains are more successful in culminating into vaginal delivery if the neck of womb that is the cervix is soft (ripe). this is usually achieved by ripening agents. they include drugs and devices that help soften the cervix. misoprostol and foley's balloon catheter both are used to soften the cervix so that vaginal delivery is possible. both work on different aspects of the softening of cervix. misoprostol acts on shortening the cervix and making it more pliable foley's balloon helps to open up the cervix that is it aids in dilating the cervical canal.

Eligibility criteria:
inclusion criteria: * gestational age \> 37 weeks assessed by last menstrual period and dating scan. * women with singleton pregnancy assessed by ultrasound. * fetus in vertex presentation assessed by ultrasound. * age 20-40 years. * bishop score \<4. exclusion criteria: * non-consenting. * gestational age \< 37 weeks. * patients with history of placenta previa. * patients with history of placental abruption. * ruptured membranes. * patients with history of vaginal infection. * patients with history of congenital anomalies in previous deliveries. * patients with history of stroke, renal impairment and chronic obstructive pulmonary disease, chronic liver disease and congestive cardiac failure

Keywords: induction of labor misoprostol foley's balloon catheter
distinguishing non-specific low back pain from scoliosis-related pain via quality of life questionnaires

Conditions: Idiopathic Scoliosis; Degenerative Scoliosis

Summary: vertebral deformities, such as scoliosis, can have a significant impact on the physical and psychological health of patients. over time, specific tools have been developed to investigate the extent of this impact; the srs-22 (scoliosis research society) questionnaire is the most commonly used instrument for assessing quality of life (qol) in patients with idiopathic scoliosis. the oswestry disability index (odi), on the other hand, was developed to evaluate the quality of life in adult patients with chronic non-specific low back pain. the clinical protocols at our institute involve the regular and continuous evaluation of the quality of life in patients undergoing treatment and monitoring for scoliosis and other vertebral deformities. to this end, the srs-22 questionnaire and the odi questionnaire are employed, along with other measures such as the comi (core outcome measure index) and isyqol (italian spine youth quality of life). the aim of this study is to compare the properties of the odi with those of the srs-22 questionnaire in adults, by analyzing differences between individuals with non-specific low back pain and those with scoliosis. the secondary objective involves a sub-analysis based on the severity of scoliosis, dividing curves into major (30° cobb or higher) and minor (below 30° cobb). finally, if sufficient data are available, the study will also evaluate other commonly used questionnaires (comi and isyqol).


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * diagnosis of idiopathic or degenerative scoliosis with a curve \>10° cobb and * low back pain * diagnosis of non-specific low back pain exclusion criteria: * previous spinal surgery * significant past illnesses, surgeries, or trauma * secondary scoliosis * other deformities such as spondylolisthesis and spinal canal stenosis * incomplete odi and srs-22 data
salpingectomy versus aspiration of hydrosalpingeal fluid prior to ivf-et

Conditions: Infertility

Summary: the aim of this randomized controlled trial is to compare the efficacy of ultrasound guided aspiration of hydrosalpingeal fluid with salpingectomy in the management patients with ultrasound visible hydrosalpinges undergoing ivf-et.

the adverse impact of hydrosalpinx on in vitro fertilisation embryo transfer (ivf-et) outcomes has been confirmed by several retrospective and prospective studies . cochrane review of prospective randomised trials of laparoscopic salpingectomy confirmed the beneficial effect of laparoscopic salpingectomy on ivf-et outcomes in patients with hydrosalpinges. surgery is not usually safe especially in patients with extensive adhesions, morbid obesity or previous multiple laparotomies. furthermore, many infertile couples refuse to undergo bilateral salpingectomy or proximal tubal occlusion because these procedures remove any hope of spontaneous pregnancy. other less invasive options for patients with hydrosalpinges as ultrasound-guided aspiration of hydrosalpingeal fluid, antibiotics (alone or combined with aspiration) and hysteroscopic occlusion of fallopian tube were studied in order to find an alternative to salpingectomy . although these methods are simple and getting popular, current data are inadequate to recommend these treatment options instead of salpingectomy because most of the supporting evidences for these methods come from small retrospective studies. a recent randomized controlled trial revealed that the aspiration of hydrosalpingeal fluid at the time of oocyte retrieval was associated with improved implantation rate and pregnancy rates. the aim of this randomized controlled trial is to compare the efficacy of ultrasound guided aspiration of hydrosalpingeal fluid with salpingectomy in the management patients with ultrasound visible hydrosalpinges undergoing ivf-et

Eligibility criteria:
inclusion criteria: * patients with unilateral or bilateral hydrosalpinges visible by ultrasound * age between 18 - 37 years * period of infertility \> 1 year * body mass index between 19-29 * normal basal luteinizing hormone (lh), follicle stimulating hormone (fsh) and prolactin concentrations. * normal recent semen analysis (according to world health organization criteria). exclusion criteria: * uterine fibroid requiring surgical removal. * endometriosis. * male factor of infertility requiring icsi, previous ivf cycles. * history of recurrent miscarriage. * endocrinologic disorders. * presence of systemic disease contraindicating pregnancy.

Keywords: infertility hydrosalpinx ivf-et salpingectomy
sleep apnea study in adults using dreamport-eclipse and a traditional nasal mask

Conditions: Obstructive Sleep Apnea

Summary: the randomized controlled trial of bleep dreamport-eclipse study is a two-arm, randomized, prospective, non-blinded study to assess the effectiveness of the novel cpap human interface design to improve leak, ahi, and pressure compared to a traditional nasal mask.


Eligibility criteria:
inclusion criteria: • male or female ≥18 years old who are impacted by obstructive sleep apnea and currently are familiar with a cpap device exclusion criteria: * any medical or behavioral conditions that would compromise subject safety * under the age of 18 years old
a real-world study evaluating the usage of camrelizumab in chinese patients with advanced esophageal cancer

Conditions: Esophageal Cancer

Summary: the trial is a multi-center, open, observational registration study, which aims to evaluate the safety and efficacy of camrelizumab (anti-pd-1 antibody) in the treatment of chinese patients with advanced esophageal cancer in the real world.


Eligibility criteria:
inclusion criteria: 1. sign informed consent and voluntarily participate in this study. 2. unresectable locally advanced/recurring or distant metastatic esophageal cancer patients confirmed by histology or cytology (ajcc 8th edition); * unresectable locally advanced patients who are unable or unable to receive radical treatment (including radical radio chemotherapy or radical radiotherapy, etc.) may be considered for inclusion; * patients who progress or relapse after neoadjuvant or adjuvant therapy may also be considered for inclusion; 3. age ≥ 18 years old; 4. the investigator determines that the patient can receive camrelizumab as a single agent or combination therapy. exclusion criteria: 1. evidence suggests that the patient is pregnant or breastfeeding; 2. other drug blinded clinical trials are currently underway; 3. other situations that are not suitable for inclusion in this study.
comparative study of microwave radiometry and ultrasonography for the diagnosis of acute appendicitis

Conditions: Appendicitis

Summary: this study will evaluate the use of microwave radiometry in a population of patients diagnosed with acute appendicitis and treated with appendectomy. the main purpose of the study is to report the results of microwave radiometry as a diagnostic tool in acute appendicitis and compare those results with the commonly used ultrasonography.

patients diagnosed with acute appendicitis from the emergency department of hippocration general hospital and treated with appendectomy will be evaluated with microwave radiometry for changes in the temperature of the appendix before its removal. subsequently, the results of microwave radiometry for the patients confirmed by the histopathology report to have acute inflammation of the appendix, will be compared with those of the ultrasonography used for the diagnosis of acute appendicitis.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of appendicitis * surgical removal of appendix * pathological confirmation of appendicitis exclusion criteria: -

Keywords: appendicitis diagnosis microwave radiometry ultrasonography
medication responsiveness in parkinson's disease

Conditions: Parkinson Disease; Medication Compliance; Tapping Task; Smartphone

Summary: up till now, dopaminergic replacement is considered as the gold standard for the symptomatic treatment of motor symptoms in parkinson's disease (pd). however, the intake, especially higher doses when taken for a longer duration, are associated with several side effects including response fluctuations. these fluctuations in medication response are often characterized by a wearing-off period, also defined as the recurrence of pd symptoms before a patient should take the next dose of medication. the duration of test sessions during research experiments (e.g. in the field of rehabilitation) can interfere with the period of the optimal therapeutic effect of dopaminergic medication, influencing outcomes of a study. therefore, the objective of this project is to get more insight in the measurability of on-off fluctuations by testing the applicability of a short and simple timed tapping task (ttt) on a smartphone in rehabilitation research studies. the assessment can be useful for future clinical studies in pd where a precise estimation of medication is indispensable for accurate research outcomes.


Eligibility criteria:
inclusion criteria: * a diagnosis of pd, based on the uk brain bank diagnostic criteria * hoehn \& yahr stage i-iii * mini mental state examination (mmse) scores \>24 * right-handedness * no other known disease or disorder that will interfere with the experiments
a feasibility study to compare the benefits of endoscopic tumor clip placement and 3t-mri simulation for accurate target volume definition for rectal cancer patients undergoing pre-operative chemoradiation

Conditions: Rectal Cancer

Summary: this study is looking for a better way to define rectal tumors undergoing pre-operative radiation. mri scanning generally results in more clear definition of the tumor that ct scanning. insertion of radio opaque clips in the tumor site could also help to visualize the tumor better for radiotherapy treatment planning. the investigators believe both techniques would help the physician to define to cancer better than using ct scan alone. the investigators also will compare both techniques to define the better way to define the tumor.

1. the use of endoscopically placed mucosal metal clips to define the superior and inferior extent of the rectal tumor will improve the accuracy of tumor localization in patients undergoing non-contrast ct simulation. 2. a 3t-mri will provide a better localization of the rectal tumor and pelvic nodes compared to non-contrast ct simulation for radiotherapy treatment planning. 3. by comparing these two novel methods to the standard procedure, we would be able to define any difference between the three methods and obtain an estimate of the accuracy and reliability of each method for the localization of the rectal tumor.

Eligibility criteria:
inclusion criteria: * patients with adenocarcinoma of the rectum stage as t3/4 n0/1/2 m0 undergoing pre-operative chemoradiation * patients must be 18 years of age or greater * signed study-specific informed consent * not pregnant or lactating exclusion criteria: * contraindication for radiotherapy or chemoradiation * contraindication for mri scanning * prior chemotherapy or radiation therapy to the pelvis

Keywords: radiotherapy ct simulation mri simulation endoscopic clip placement rectal cancer accuracy of mri simulation for target delineation and planning
the use of ffr guided pci versus complete revascularization and treatment of infarct related artery only in patients with stemi

Conditions: Multivessel Coronary Artery Disease; STEMI; FFR Guided PCI

Summary: in patients with st elevation myocardial infarction (stemi) the treatment goal is revascularization of the occluded artery with the use of primary percutaneous coronary intervention (pci). there is a large subset of patients with stemi who also have significant disease in arteries other than the site of occlusion, and away from the culprit artery. it is estimated that up to 50% have disease of more than 50% in the non-culprit arteries. the evidence on how to treat those patients with multi vessel disease is conflicting. earlier large-scale studies and registries have suggested early and complete revascularization is of no benefit or even harmful. more recent studies have showed the opposite of that. the cvlprit study showed that early complete revascularization or preventive pci reduced primary endpoint of a composite of all cause mortality, myocardial infarction and need for repeat revascularization. the benefit was mainly due to reduced repeat revascularization in the more intensive intervention group. the prami study showed very similar results as well. the use of fractional flow reserve (ffr) in deciding complete revascularization has also showed conflicting results so far. a previous trial showed that ffr guided intervention post stemi increased mace. this was conflicted with more recent study, which showed ffr guided complete revascularization improved outcome when compared with more conservative treatment of ischaemia driven intervention. in this study, the investigators are going to assess the issue of staged revascularization guided by ffr or by angiogram, compared to the standard treatment of ischaemia driven revascularization

to compare the clinical outcomes measured by composite of mortality, myocardial infarction and repeat revascularization by using ffr guided and angiographically guided revascularization to the standard strategy of ischaemia driven revascularization. participants will be allocated to three arms, first conservative group of ischaemia guided pci, second ffr guided pci and third angiogram guided pci where patients where patients with more than 50% lesion will undergo revascularization.

Eligibility criteria:
inclusion criteria: 1. patients with stemi and multi-vessel disease on initial angiogram. 2. above 18 years of age 3. able to give consent exclusion criteria: 1. patients with indication for cabg 2. left main stem lesion of \>50% 3. cardiogenic shock 4. intractable angina during hospital admission 5. patients with limited life expectancy 6. patients with severe chronic kidney disease 7. patients with contraindication to dual antiplatelet therapy 8. patients with very complex lesions that deemed not favourable for pci 9. pregnancy or childbearing age
computer-based comprehensive geriatric assessment in oncology for individuals 70 or older with gastrointestinal malignancies

Conditions: Rectal Cancer; Breast Cancer; Lung Cancer

Summary: older individuals account for one-third of new cancer cases and cancer-related deaths in the united states. older individuals are more susceptible to having a decrease in physical and mental function following chemotherapy treatment. geriatric assessment may provide a way to identify those older individuals at greatest risk of functional decline before treatment starts and during the period of treatment. geriatric assessment includes a set of screening questions and tests designed to determine the physical and mental status of the individual at a point in time. geriatric assessment also includes review of medications and other medical conditions the individual may have that may affect function. the investigators are conducting this study to determine if older individuals are able to complete the geriatric assessment using a computer format and how that corresponds to their treating physician's assessment of their functional status before and after starting a new chemotherapy treatment for colon, rectal, breast or lung cancer. the investigators will also evaluate the usefulness of a computerized form of geriatric assessment.

* participants will complete the geriatric assessment on the computer either at their home via the web (if they have internet access) or in the clinic at their next visit prior to seeing the doctor. * all individuals will have a unique way to sign on to the computer program that protects the information so that only the participant and the research team will be able to view it. individuals who require assistance to answer the questions will have help provided by a research assistant. * we will ask participants to complete the geriatric assessment a second time at 4 months after they have enrolled on the study or 1 month after completing their chemotherapy treatment, whichever occurs first.

Eligibility criteria:
inclusion criteria: * ability to understand and the willingness to sign a written informed consent document * patients with colorectal, breast or lung cancer at any stage who are under consideration for initiation of or change in cytotoxic chemotherapy regimen. patients must start chemotherapy within 4 weeks of enrollment. chemotherapy regimens may include traditional cytotoxic therapy, oral biological agent, or combination of a biologic therapy and cytotoxic chemotherapy. * patients age 70 or older at enrollment * patients must be able to read english and able to complete the web-based computer questionnaire exclusion criteria: * patients with a physical limitation preventing computer use (visual impairment, inability to use computer mouse or touch screen). * patients who are hospitalized or enrolled in hospice

Keywords: geriatric assessment