Kornimate/medical-research-clean huggingface dataset:
chlorpheniramine nasal spray to accelerate covid-19 clinical recovery in an outpatient setting: accros-iii

Conditions: COVID-19; Symptoms and Signs; COVID-19 Pandemic; Coronavirus Disease 2019; Coronavirus Infections

Summary: the goal of this clinical trial is to examine the effectiveness of intranasal-administered chlorpheniramine maleate in covid-19-positive participants as part of early treatment for covid-19. the main questions it aims to answer are: * to assess the efficacy of nasal spray with chlorpheniramine (0.4%) for improving clinical recovery in covid-19 patients. * to assess the efficacy, safety, and tolerability of nasal spray with chlorpheniramine (0.4%) as an adjunct to the standard of care in reducing hospitalizations and improving clinical recovery in adult patients with mild covid-19.

the main goal of the present study is to examine the effectiveness of cpm intranasal spray as part of early treatment for covid-19. the study will test the hypothesis that intranasal cpm would accelerate clinical recovery, particularly the alleviation of sensory symptoms and urs, in patients with covid-19.

Eligibility criteria:
inclusion criteria: * male or female patients between 18 and 65 years (both inclusive) * patients with positive rt-pcr test for sars-cov-2 in nasopharyngeal or oropharyngeal swabs (sample collected or proof of positive test ≤3 days before randomization) * patients with mild covid-19 have the following symptoms and signs prior to randomization (≤ 3days) * upper respiratory tract symptoms (\&/or fever) without shortness of breath or hypoxia. (spo2 \> 94 %) * willingness to sign written informed consent document exclusion criteria: * \< 18 years of age * hospitalized patients * subject with known allergy or hypersensitivity to the components of the formulation. * patients receiving therapy with monoamine oxidase inhibitors (maois): rasagline, selegiline, isocarbonboxasid, phenelzine, tranylcypromine. * patients with narrow-angle glaucoma * urinary retention * sleep apnea * history of immunodeficiency or receiving immunosuppressive therapy. * patients with acute exacerbation of severe comorbidities such as chronic obstructive pulmonary disease (copd), class 3 and 4 heart failure diagnosed according to the criteria of the new york heart failure association (nyha), or diseases with severe oxygenation problems * any surgical procedure in the past 12 weeks * unable to make informed consent or refuse or renounce adherence to standard treatment protocols. * any significant illness or drugs that could interfere with study parameters * any other condition based on the investigator's clinical judgment does not justify the patient's participation in the study. * participation in another clinical trial within the past 30 days * clinically significant arrhythmia or symptomatic cardiac conditions including but not limited to qt elongation * qt interval less than 300 ms or more than 500 ms for both men and women.
cortical processes during walking post-stroke

Conditions: Stroke, Acute; Walking, Difficulty

Summary: the study aims to use novel mobile imaging techniques with high-density electroencephalography (eeg) to quantify cortical processes synchronized to the biomechanics of walking. here, the study has two aims - the primary aim is to quantify the cortical processes that contribute to gait dysfunction early post-stroke, and the second aim is to determine how cortical processes are mediated by mechanical assistance during early gait training post-stroke. participants will wear an electroencephalography (eeg) cap to measure brain activity and other non-invasive physiological sensors. participants will be asked to perform different tasks, such as walking at different speeds and walking with different levels of body weight support.

this study will recruit 15 subacute post-stroke individuals and 15 age-matched neurotypical individuals between the age of 18-80 years old.

Eligibility criteria:
inclusion criteria for post-stroke patients: * participants will have a unilateral brain lesion within six months prior to participation in this project; * paresis confined to one side; * ability to walk for 10 meters continuously; * absence of severe cognitive dysfunction as demonstrated by a mini-mental score greater than 24; * absence of severe concurrent medical problems; * ability to provide informed consent. exclusion criteria for age-matched adults: * any major neurological, cardiovascular, orthopedic, and psychiatric diagnoses

Keywords: walking stroke eeg assistance
a decision aid for women with early stage breast cancer

Conditions: Breast Cancer

Summary: to enhance information transfer and decision making for women with breast cancer.

our specific objectives are: (i) to develop computer and paper based versions of the decision boards for (a) chemotherapy for early stage breast cancer (chemotherapy versus no treatment), (b) mastectomy versus lumpectomy plus radiation and (ii) to compare the relative effectiveness of the computer and paper based versions with the standard decision board for patients with early breast cancer.

Eligibility criteria:
inclusion criteria: chemotherapy group: * female * histologically documented invasive carcinoma of the breast treated with modified radical mastectomy or lumpectomy * axillary node dissection * chemotherapy alone or in addition to tamoxifen as an appropriate treatment option surgery group: * female * newly diagnosed carcinoma of the breast diagnosed either by cytology or pathological examination, or if no biopsy, a strong clinical suspicion of malignancy * clinical stage i or ii disease * candidate for breast conserving surgery exclusion criteria: chemotherapy group: * candidate for cef chemotherapy * clinical evidence of metastatic disease * serious comorbidity that would preclude receiving chemotherapy treatment * unable to speak or read english fluently (including visual impairment) * mentally incompetent including any psychiatric or addictive disorders that would preclude shared decision-making surgery group: * previous surgery for breast cancer * previous breast irradiation * pregnant * clinical suspicion of bilateral breast cancer * serious comorbidity that would preclude definitive surgery * unable to speak or read english fluently (including visual impairment) * mentally incompetent including any psychiatric or addictive disorder that would preclude shared decision making

Keywords: breast cancer decision aid decision board information transfer
an investigational drug study in the treatment of primary dysmenorrhea (0663-064)

Conditions: Dysmenorrhea

Summary: the purpose of this study is to evaluate the pain relieving effect and safety of an investigational drug in women with moderate to severe primary dysmenorrhea (painful menstruation).


Eligibility criteria:
inclusion criteria: * women 18 years of age or older suffering from painful menstruation exclusion criteria: * women taking medications that are not allowed in the study (such as pain medications, antidepressants, tranquilizers, hypnotics, sedatives, or oral contraceptives). * women who are pregnant, breast-feeding or within 6 weeks of giving birth
the effect of extracorporeal shock wave therapy on carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: the shock wave is a new and potential intervention for the reinnervation of peripheral nerve. the purpose of this study was to assess the effect of extracorporeal shock wave therapy on carpal tunnel syndrome.

recently, many studies show the potential effect of shock wave for the reinnervation for peripheral neuropathy in the animal mode. only one study reveal the potential benefit of shock wave in patients with carpal tunnel syndrome. althouh its expressive finding, the number of cases is relatively too small to make a conclusive remark. large and well-designed study would expand the new field.

Eligibility criteria:
inclusion criteria: outpatient subjects who had typical symptoms and signs of cts, such as positive tinel's sign or phalen's test and numbness/tingling in at least two of the first, second, and third digits and were all confirmed by electrophysiological study, were considered and enrolled. exclusion criteria: the patients who had conditions mimicking cts, such as cervical radiculopathy, polyneuropathy, brachial plexopathy, thoracic outlet syndrome or who had previous wrist surgery or steroid injection for cts, were all excluded.

Keywords: shock wave carpal tunnel syndrome
a trail of neoadjuvant endostar in combination with chemotherapy in breast cancer

Conditions: Stage III Breast Cancer

Summary: the trial was designed to study the efficacy and safety of neoadjuvant docetaxel, epirubicin in combination with cyclophosphamide(dec) plus human recombinant endostatin (endostar) for breast cancer patients. the hypothesis of this protocol is that the combined an active angiogenesis agent to chemotherapy could enhance the pathological responce rate and further benefit breast cancer patients.


Eligibility criteria:
inclusion criteria: * histologically confirmed invasive breast cancer (core needle biopsy for breast cancer diagnosis and fine needle aspiration for lymph node metastasis diagnosis) * age 18-70 * no evidence of distant metastasis * no previous therapy * normal hematologic function * no abnormality of renal or liver function * written informed consent exclusion criteria: * with allergic constitution or possible allergic reflection to drugs to be used in this study * any concurrent uncontrolled medical or psychiatric disorder * history of severe heart diseases, including congestive heart failure, unstable angina, uncontrolled arrhythmia, myocardial infarction, uncontrolled high blood pressure, or heart valve disease * being pregnant or nursing
united states hypophosphatasia molecular research center

Conditions: Hypophosphatasia

Summary: this study is being done to determine if cryptic alterations exist within or near to the alpl gene in patients with a clinical diagnosis of hypophosphatasia, but without identifiable alteration on commercial testing. additionally, the study aims to characterize functional effects of certain variants of uncertain significance in patients with clinical diagnosis of hypophosphatasia.

primary study objectives: determine if cryptic alterations exist within or near to the alpl gene in patients with clinical diagnosis of hypophosphatasia, but without identifiable pathogenic or likely pathogenic variant on commercial testing. secondary study objective(s): characterize functional effects of variants of uncertain significance in patients with clinical diagnosis of hypophosphatasia further characterize the differential diagnosis of hypophosphatasemia in patients with skeletal disease

Eligibility criteria:
inclusion criteria: aim 1- 1. diagnosis of hypophosphatasia based on clinical features that include * history consistent with diagnosis of hypophosphatasia and * physical examination findings consistent with a diagnosis of hypophosphatasia and * presence of low serum alkaline phosphatase level for age and sex and * elevation of at least one natural substrate of alkaline phosphatase 2. lack of detection of a variant on molecular analysis of the alpl gene. when possible, first degree relatives (parents, siblings, or child) will be included for the sole purpose of trio testing. no additional information will be collected on first degree relatives. aim 2- 1. missense variant in alpl which is interpreted as a variant of uncertain significance by the american college of medical genetics guidelines for variant interpretation 2. variant has been interpreted as pathogenic, likely pathogenic, likely benign, or benign using ex-us interpretation guidelines exclusion criteria: aim 1- 1. history and physical examination incompatible with a diagnosis of hypophosphatasia or 2. absence of hypophosphatasemia as measured by age and sex-matched control or 3. absence of at least one elevated natural substrate of alkaline phosphatase or 4. alternate diagnosis which could overlap with signs and symptoms of hypophosphatasia aim 2- 1. inability to express variant in plasmid for residual enzyme and co-transfection analyses
a positive food parenting intervention to promote healthy growth in children at risk for obesity

Conditions: Pediatric Obesity; Nutrition Disorder

Summary: this study is the pilot of a 12 - week positive food parenting intervention focused on structure-based and autonomy promoting practices. the intervention aims to give parents the tools to promote healthy child growth and improve diet quality. the investigators are piloting to assess feasibility and efficacy of the intervention through examining participant retention, impact on parent feeding practices, and impact on parent and child diet quality.


Eligibility criteria:
parent criteria: inclusion criteria: * age \> 18 years old. * have a child between the ages of 5 - 11 who is at risk for obesity (child bmi percentile \> 85th) or parent it concerned about their child developing overweight or obesity * low use of positive food parenting (defined as: low reports of individual nutrition education/ knowledge or reports low levels of structure, involvement, or encouragement in their food parenting practices) * must be responsible for feeding their eligible child at least 50% of the time. * fluent in english. * have access to internet and a zoom compatible device. exclusion criteria: * age is \< 18 years old. their child is determined ineligible (based on bmi percentile and age). * does not report low use of positive food parenting (as defined above). * is responsible for feeding their eligible child \< 50% of the time. * not fluent in english. * does not have access to internet and a zoom compatible device. * on medication that could influence their eating or feeding behaviors. child criteria: inclusion criteria: * their parent/ guardian is eligible and participating in the study. * ages 5 - 11 * is not current diagnosed with a clinical eating disorder (ed). * is not on any medications, or have any conditions, that could influence the child's taste, appetite, or olfactory sensory responsiveness. exclusion criteria: * their parent/ guardian is not eligible nor participating in the study. * below the age of 5 and above the age of 11. * bmi percentile \ 97th. * current diagnosis of a clinical eating disorder (ed) * medications or conditions that could influence the child's taste, appetite, or olfactory sensory responsiveness.

Keywords: children parenting parent feeding practices food parenting obesity risk positive food parenting autonomy promotion structure - based food parenting
prediction of future weight change with dopamine transporter

Conditions: Weight Change, Body

Summary: this is the re-analyzing study of observational study by parkinson's progression markers initiative


Eligibility criteria:
inclusion criteria: * males or females with their age of 30 years or older at screening exclusion criteria: * subjects with a neurological disorder, a first degree relative with idiopathic pd, montreal cognitive assessment score of 26 or less, medications that might interfere with dat spect scans, anticoagulants that might preclude safe completion of the lumbar puncture, or investigational drugs, and a condition that precludes the safe performance of routine lumbar puncture
qudratus lumborum block for postoperative pain after endoscopic prostatectomy.

Conditions: Prostate Cancer

Summary: laparoscopic prostatectomy (lp) is characterized by substantial tissue trauma, despite its minimally -invasive approach. although postoperative pain intensity is lower when compared to open procedures, the use of opioids is common. retrospective review of available lp cases revealed that although analgesic demand varied, nearly all of our lp patients required opioids postoperatively. bilateral quadratus lumborum block (qlb), being one of relatively new features of regional anesthesia, offers good analgesia of abdominal wall, with the potential for control of visceral pain. this study was established to evaluate its effectiveness in alleviating pain after radical prostatectomy in a double - blind, placebo - controlled manner.


Eligibility criteria:
inclusion criteria: * asa status less or equal 3 * scheduled for transperitoneal or extraperitoneal endoscopic prostatectomy * able to understand information provided and to sign the informed consent for participation in the study exclusion criteria: * known allergy to local anesthetics and opioids * infection in the area of block placement * known chronic use of opioids, gabapentinoids and tricyclic antidepressants * mental inability to understand the principles and rules of patient-controlled analgesia pump

Keywords: regional anesthesia quadratus lumborum block patient controlled anesthesia laparoscopic prostatectomy
comparative study of use of alpha-blockers to treat symptoms in prostate cancer patients undergoing radiation therapy

Conditions: Urinary Problems; Prostate Cancer

Summary: approximately 50%-95% of prostate cancer patients undergoing radiation therapy (rt) develop symptomatic urinary problems .these symptoms can significantly diminish a patient's quality of life during and shortly after therapy. alpha1-blockers, such as rapaflo, act to decrease resistance to urinary flow. this multi-institutional phase iii trial is designed to compare standard of care versus preventive treatment with rapaflo for prostate cancer patients, regardless of risk group, whose treatment consists of radical radiation therapy. we plan to recruit 188 patients across quebec who will be randomized into two arms: rapaflo prescribed at start of radiation therapy or if/when symptoms appear.

the efficacy of rapaflo treatment will be assessed using the international prostate symptom score (ipss). the ipss will be assessed at baseline before rt, 4 weeks into rt, the last day of rt, and monthly thereafter for a total duration of 6 months from start of rt. patients will have 2 more ipss assessments at 9 and 12 months. the total duration of follow-up will be one year from start of rt. we will compare the rate of ipss increase in the rapaflo group compared to the standard arm at different time point (4 weeks, 6 weeks and at the end of treatment). we will also determine the rate of ipss return to baseline at 4 and 12 weeks after the end of treatment. the rate of therapy dependence in the 2 arms will be evaluated at 20 and 26 weeks.

Eligibility criteria:
inclusion criteria: * adult male 18 years of age or older * patients with confirmed diagnosis of adenocarcinoma of the prostate. * the primary treatment should be external beam radiation therapy (ebrt) with or without high dose rate (hdr) brachytherapy boost. * clinical or radiological diagnosis of t1a - t3b. * no limitation with respect to gleason score. * no limitation with respect to total prostate-specific antigen (psa) value. * karnofsky performance score (kps) of ≥ 70. exclusion criteria: * small cell cancer of the prostate * t4 disease, invading bladder or rectum. * adjuvant or salvage radiation therapy * brachy monotherapy * kps \< 70

Keywords: alpha-blocker symptomatic urinary problems radiation therapy prostate cancer
povidone-iodine irrigation for prevention of intra-abdominal abscess in pediatric perforated appendicitis: a multi-center stepped wedge cluster randomized study

Conditions: Acute, Perforated Appendicitis

Summary: the purpose of this study is to determine the effect of intra-abdominal irrigation with povidone-iodine (pvi) versus usual care on the rate of 30-day postoperative intra-abdominal abscesses (iaa) and to determine the effect of pvi irrigation versus usual care on 30-day hospital length of stay(los) and 30-day readmissions.


Eligibility criteria:
inclusion criteria: * admitted to a participating center * appendectomy performed for acute appendicitis * intraoperative diagnosis of perforated appendicitis exclusion criteria: * simple or gangrenous appendicitis * interval or incidental appendectomy * initial attempt at non-operative management (defined as \>48 hours between the time of diagnosis and surgical intervention) * history of iodine allergy, thyroid disease or renal dysfunction * pregnancy
web-based acceptance and commitment therapy for hoarding disorder

Conditions: Hoarding Disorder

Summary: this study will help to determine if acceptance and commitment therapy delivered as a web-based intervention is a useful treatment for hoarding disorder and evaluate whether or not web-based treatment for hoarding is credible and acceptable. it may also help identify novel processes of change in hoarding treatment such as psychological inflexibility, mindfulness, and self-stigma.

the efficacy of an act self-help website for hoarding will be assessed through a randomized, waitlist-controlled trial. participants will be recruited from within the united states through a variety of channels. given the need to recruit a targeted sample with clinical levels of hoarding symptoms, online advertisements through facebook and google adwords will be the primary recruitment method. participants will complete an initial brief screening, provide consent, and then complete a baseline survey. each of these steps will be completed online and participants will be automatically guided from each step to the next. that is, those who screen as eligible will be automatically directed to an online consent form, and those who provide consent will be automatically directed to begin the initial online baseline survey. they will be randomly assigned automatically upon completing the baseline survey to either use the act self-help website and receive supportive coaching for the next 8 weeks, or wait for the next 8 weeks. after 8 weeks, participants will be asked to complete a posttreatment survey. they will be asked to complete a final, follow-up survey after an additional 4 weeks after the posttreatment survey. after the follow-up survey is completed, waitlisted participants will be provided with access to the website. the website will implement a self-help version of act. participants will be asked to complete 16 brief self-help website sessions, each taking around 15-20 minutes to finish, twice a week for eight weeks. participants assigned to the website condition will also receive coaching.the purpose of coaching will be to help participants engage with the website and adhere to the intervention. coaching will consist of an initial phone call of 10-15 minutes followed by weekly email contact during the 8-week treatment period. coaches will be graduate students trained in clinical psychology.

Eligibility criteria:
inclusion criteria: 1. 18 years old or older 2. living in the usa 3. seeking help for clutter and/or hoarding 4. interested in testing a self-help website 5. scoring at or above the clinical cutoff of 41 on the saving inventory-revised exclusion criteria: 1. 17 years or younger 2. living outside the usa 3. not seeking help for clutter and/or hoarding 4. not interested in testing a self-help website 5. scoring below 41 on the saving inventory-revised