tissue sample collection from patients with head and neck cancer and from healthy participants

Conditions: Head and Neck Cancer

Summary: rationale: collecting and storing samples of tissue, saliva, and blood from patients with cancer and from healthy participants to study in the laboratory may help the study of cancer in the future. purpose: this research study is collecting and storing tissue samples from patients with head and neck cancer and from healthy participants.

objectives: * maintain and update a clinical database pertaining to diagnosis and treatment outcome of patients with head and neck cancer. * develop a repository of biospecimens from these patients. outline: tumor tissue samples and/or bronchial washings are collected from patients undergoing planned surgery and/or bronchoscopy, respectively. buccal swabs and/or mouthwash samples and saliva samples are collected. patients also undergo blood sample collection at baseline and then every 2-6 months thereafter. healthy participants contribute blood samples, buccal swabs, and mouthwash samples at baseline only. information about medical and family history and cancer risk factors is also collected. projected accrual: no limit. follow up: indefinite, until date of death or lost to follow up.

Eligibility criteria:
disease characteristics: * meets 1 of the following criteria: * diagnosis of head and neck cancer * being treated at vanderbilt university medical center for the cancer * healthy participant patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: stage i squamous cell carcinoma of the hypopharynx stage ii squamous cell carcinoma of the hypopharynx stage iii squamous cell carcinoma of the hypopharynx stage iv squamous cell carcinoma of the hypopharynx recurrent squamous cell carcinoma of the hypopharynx stage i squamous cell carcinoma of the larynx stage i verrucous carcinoma of the larynx stage ii squamous cell carcinoma of the larynx stage ii verrucous carcinoma of the larynx stage iii squamous cell carcinoma of the larynx stage iii verrucous carcinoma of the larynx stage iv squamous cell carcinoma of the larynx stage iv verrucous carcinoma of the larynx recurrent squamous cell carcinoma of the larynx recurrent verrucous carcinoma of the larynx stage i adenoid cystic carcinoma of the oral cavity stage i basal cell carcinoma of the lip stage i mucoepidermoid carcinoma of the oral cavity stage i squamous cell carcinoma of the lip and oral cavity stage i verrucous carcinoma of the oral cavity stage ii adenoid cystic carcinoma of the oral cavity stage ii basal cell carcinoma of the lip stage ii mucoepidermoid carcinoma of the oral cavity stage ii squamous cell carcinoma of the lip and oral cavity stage ii verrucous carcinoma of the oral cavity stage iii adenoid cystic carcinoma of the oral cavity stage iii basal cell carcinoma of the lip stage iii mucoepidermoid carcinoma of the oral cavity stage iii squamous cell carcinoma of the lip and oral cavity stage iii verrucous carcinoma of the oral cavity stage iv adenoid cystic carcinoma of the oral cavity stage iv basal cell carcinoma of the lip stage iv mucoepidermoid carcinoma of the oral cavity stage iv squamous cell carcinoma of the lip and oral cavity stage iv verrucous carcinoma of the oral cavity recurrent adenoid cystic carcinoma of the oral cavity recurrent basal cell carcinoma of the lip recurrent mucoepidermoid carcinoma of the oral cavity recurrent squamous cell carcinoma of the lip and oral cavity recurrent verrucous carcinoma of the oral cavity metastatic squamous neck cancer with occult primary squamous cell carcinoma recurrent metastatic squamous neck cancer with occult primary untreated metastatic squamous neck cancer with occult primary stage i lymphoepithelioma of the nasopharynx stage i squamous cell carcinoma of the nasopharynx stage ii lymphoepithelioma of the nasopharynx stage ii squamous cell carcinoma of the nasopharynx stage iii lymphoepithelioma of the nasopharynx stage iii squamous cell carcinoma of the nasopharynx stage iv lymphoepithelioma of the nasopharynx stage iv squamous cell carcinoma of the nasopharynx recurrent lymphoepithelioma of the nasopharynx recurrent squamous cell carcinoma of the nasopharynx stage i lymphoepithelioma of the oropharynx stage i squamous cell carcinoma of the oropharynx stage ii lymphoepithelioma of the oropharynx stage ii squamous cell carcinoma of the oropharynx stage iii lymphoepithelioma of the oropharynx stage iii squamous cell carcinoma of the oropharynx stage iv lymphoepithelioma of the oropharynx stage iv squamous cell carcinoma of the oropharynx recurrent lymphoepithelioma of the oropharynx stage i esthesioneuroblastoma of the paranasal sinus and nasal cavity stage i inverted papilloma of the paranasal sinus and nasal cavity stage i midline lethal granuloma of the paranasal sinus and nasal cavity stage i squamous cell carcinoma of the paranasal sinus and nasal cavity stage ii esthesioneuroblastoma of the paranasal sinus and nasal cavity stage ii inverted papilloma of the paranasal sinus and nasal cavity stage ii midline lethal granuloma of the paranasal sinus and nasal cavity stage ii squamous cell carcinoma of the paranasal sinus and nasal cavity stage iii esthesioneuroblastoma of the paranasal sinus and nasal cavity stage iii inverted papilloma of the paranasal sinus and nasal cavity stage iii midline lethal granuloma of the paranasal sinus and nasal cavity stage iii squamous cell carcinoma of the paranasal sinus and nasal cavity stage iv esthesioneuroblastoma of the paranasal sinus and nasal cavity stage iv inverted papilloma of the paranasal sinus and nasal cavity stage iv midline lethal granuloma of the paranasal sinus and nasal cavity stage iv squamous cell carcinoma of the paranasal sinus and nasal cavity recurrent esthesioneuroblastoma of the paranasal sinus and nasal cavity recurrent inverted papilloma of the paranasal sinus and nasal cavity recurrent midline lethal granuloma of the paranasal sinus and nasal cavity recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity stage i salivary gland cancer stage ii salivary gland cancer stage iii salivary gland cancer stage iv salivary gland cancer recurrent salivary gland cancer recurrent squamous cell carcinoma of the oropharynx