Kornimate/medical-research-clean huggingface dataset:
zoledronic acid as adjuvant treatment of triple-negative breast cancer

Conditions: Triple Negative Breast Cancer

Summary: triple-negative breast cancer is a special type of breast cancer with poor prgnosis and limited choices. chemotherapy is the only choice of adjuvant systemic treatment options. previous study suggested that zoledronic acid might have anti-tumor effect by eliminating the number of dtcs(disseminated tumor cell )and had been proved to be effective as adjvant therapy in postmenopausal women whose breast cancer was homonal receptor positive and who were receiving aromatase inhibitors. so it might be able to improve the survival of triple negative breast cancer patients.

triple negative breast cancer patients with high risk factor will be randomized to receive either zoledronic acid or observation after the completion of standard chemotherapy/radiotherapy. recurrence status will be followed and disease free survival will be compared. overall survival is the secondary endpoint.

Eligibility criteria:
inclusion criteria: * •adult women (≥ 18 years of age) with early stage breast cancer(stage ii-iii). * histological confirmation of estrogen and/or progesterone-receptor negative (er-), human epidermal growth factor receptor 2 negative (her2 -) breast cancer. er/pr negative: nuclear reaction\< 1%, her2 negative: her2; ihc 0,1+ or fish/cish (-) in case of ihc 2+ * axillary lymph node positive with other high risk factors: lvi, t\>5cm, grade iii * patients finish standard chemotherapy and/or radiotherapy * ecog performance status of 0,1 * adequate bone marrow, hepatic, and renal function * adequate bone marrow and coagulation function as shown by: * absolute neutrophil count (anc) ≥ 1.5 109/l;platelets\>100 x109/l;hemoglobin (hgb) \> 9.0g/dlinr \< 2 * adequate liver function as shown by: * serum aspartate aminotransferase (ast) and alanine aminotransferase (alt) \< 2.5x uln * total serum bilirubin \< 1.5 x uln * adequate renal function as shown by: * serum creatinine\< 1.5 x uln * fasting serum cholesterol \<300 mg/dl or 7.75 mmol/l and fasting triglycerides \<2.5 x uln. in case one or both of these thresholds are exceeded, the patient can only be included after initiation of statin therapy and when the above mentioned values have been achieved. * written informed consent exclusion criteria: * •another malignancy within 5 years prior to enrollment with the exception of adequately treated in-situ carcinoma of the cervix, uteri, basal or squamous cell carcinoma or non-melanomatous skin cancer. * any severe and/or uncontrolled medical conditions, eg. currently active infection * pregnant or lactating * patients unwilling to or unable to comply with the protocol

Keywords: zoledronic acid triple-negative breast cancer adjuvant treatment
colorectal cancer survivor symptom management

Conditions: Colorectal Cancer; Survivorship

Summary: objective: the aim of this study was to examine the effects of nursing interventions based on the symptom management model on symptom management, fear of recurrence, and quality of life in colorectal cancer survivors. method: the research was planned as a randomized controlled trial. the research is planned to be carried out at akdeniz university hospital. it is planned to be done with 52 patients, 26 experimental and 26 control groups. the intervention group will receive face-to-face training and telephone counseling based on the symptom management model. after the training, it is planned to provide telephone counseling for a total of 6 times, once every 2 weeks for 3 months. participant information form, memorial symptom assessment scale, fear of cancer recurrence inventory and european organization for the research and treatment of cancer quality of life questionnaire scale scale will be used to collect data.


Eligibility criteria:
inclusion criteria: 1. be 18 years or older 2. being able to read and write 3. being oriented to place, time, person 4. not having a hearing problem 5. not having a speech problem 6. being able to use the phone 7. primary medical diagnosis is colorectal cancer 8. patients who have completed primary treatment for colorectal cancer and are followed up 9. not to relapse 10. being in remission 11. having a karnofsky performance scale of 70% and above and being followed on an outpatient basis exclusion criteria: 1.patients with cognitive problems exclusion criteria from the sample during the research: 1. patient's wish to leave the study 2. continuing the outpatient follow-up of the patient in the medical oncology outpatient clinic of another institution

Keywords: colorectal cancer survivor symptom management model fear of recurrence nursing interventions quality of life
assessment of corneal endothelial function following hypoxic stress

Conditions: Fuchs' Endothelial Corneal Dystrophy

Summary: the purpose of this study is to determine the difference in the cornea's response to contact lens placement between healthy and unhealthy eyes. the amount of corneal swelling (corneal thickness) between normal and fecd patients before and after a stress test will be measured and compared.

clarity of the cornea is essential for optimal vision. the endothelium is a layer within the cornea that controls its clarity. fuchs endothelial corneal dystrophy (fecd) is a progressive disease that affects both eyes in which the endothelium is dysfunctional, causing the cornea to swell and lose its clarity. because of the vision loss associated with this swelling, corneal transplantation is needed for patients with advanced fecd. currently, there is no method to directly measure how well endothelium cells are functioning in patients with fecd. such a measurement, if it were possible, would allow physicians to identify patients who are at a higher risk of corneal swelling. the goal of this study is to establish a tool to measure and compare the amounts of corneal swelling between normal and fecd patients after a stress test is performed (the wearing of an fda-approved contact lens.) data will also be collected regarding how quickly and how well a cornea recovers from swelling in patients with healthy eyes compared to those with fecd.

Eligibility criteria:
inclusion criteria: subjects in the fuch's dystrophy arm of the study must meet following criteria: * have a clinical diagnosis of fuchs endothelial corneal dystrophy * be scheduled for corneal transplantation in the next 6 months * have no history of prior ocular surgery in study eye * have no history of contact lens intolerance * be motivated and willing to complete ocular imaging tests subjects in the healthy eyes arm of the study must meet following criteria: * have no prior history of ocular disease including ocular surface disease or glaucoma * have no history of prior ocular surgery in study eye * have no history of contact lens intolerance * be motivated and willing to complete ocular imaging tests exclusion criteria: pregnant women -

Keywords: fuch's dystrophy, fecd, fuch's endothelial corneal dystrophy
lycopene or green tea for men at risk of prostate cancer

Conditions: Prostate Cancer

Summary: rationale: lycopene and green tea may stop or delay the development of recurrent prostate cancer in patients has been treated for prostate cancer. it is not yet known whether lycopene or green tea may be more effective in preventing prostate cancer. purpose: this randomized phase ii trial is studying lycopene to see how well it works compared with green tea in preventing prostate cancer in patients previously enrolled in the protect trial

objectives: primary * to assess serum lycopene and epigallocatechin-3-gallate (green tea) levels at 6 months following randomization in patients with prostate cancer previously enrolled on protect secondary * to evaluate trial recruitment and randomization rates of patients treated with this regimen. * to evaluate intervention tolerability in patients treated with this regimen. * to evaluate compliance of patients treated with this regimen. * to evaluate trial retention of patients treated with this regimen. * to assess psa values in patients treated with this regimen. * to evaluate dietary compliance with recommendations of patients treated with this regimen. * to assess weight and body mass index of patients treated with this regimen. * to evaluate attitudes and views of men and their spouses about dietary modification and participation in long-term study. outline: patients are stratified according to psa test levels obtained from protect study recruitment clinic (\< 3.0 ng/ml vs 3.0-19.99 ng/ml). patients are randomized to 1 of 2 treatment arms.

Eligibility criteria:
inclusion criteria: psa level 2.0-2.95 ng/ml or psa level ≥ 3.0 ng/ml with a negative biopsy no major comorbidities no other cancers or prior prostate malignancy no history of allergic reactions to green tea or lycopene-containing products, including guava or watermelon exclusion criteria: no concurrent finasteride or dutasteride

Keywords: prostate cancer
stevens-johnson syndrome antimicrobial

Conditions: Stevens-Johnson Syndrome

Summary: steven-johnson's syndrome, or great multiform erythema, appears as a systemic disturbance, with skin involvement and mucous membranes, related to several factors, such as, viral or bacterial infections and mainly the administration of medicines, in general painkillers and antibiotics. the objective of this work is report the emergence of ulcerative vesicle -bubble chronic disease in areas of lips, gum, tongue and genital mucous membrane in a 26 year-old patient, leucoderma and masculine gender, in treatment of breathing infection with sulfametoxazol-trimetropima, having been diagnosed as syndrome of steven-johnson.

among the serious medicaments reactions, there are as great representative the mucocutaneous disorders immunological mediated. steven-johnson's syndrome, or great multiform erythema, appears as a systemic disturbance, with skin involvement and mucous membranes, related to several factors, such as, viral or bacterial infections and mainly the administration of medicines, in general painkillers and antibiotics. the objective of this work is report the emergence of ulcerative vesicle -bubble chronic disease in areas of lips, gum, tongue and genital mucous membrane in a 26 year-old patient, leucoderma and masculine gender, in treatment of breathing infection with sulfametoxazol-trimetropima, having been diagnosed as syndrome of steven-johnson.

Eligibility criteria:
inclusion criteria: * stevens-johnson syndrome associated with antimicrobial exclusion criteria: * not sick

Keywords: steven-johnson syndrome erythema multiform autoimmune disease
phase iii study of gemcitabine plus a cytotoxic agent versus two cytotoxic agents

Conditions: Breast Neoplasms

Summary: this is a phase iii randomized study which compares two different regimens of chemotherapy. the purpose of the study is to determine which of the two regimens will make the tumor smaller or disappear, and for how long. in addition the disease-related symptoms will be evaluated. the safety of the drugs will be determined based upon evaluation of the side effects


Eligibility criteria:
inclusion criteria: * locally advanced and/or metastatic breast cancer. * measurable disease * previously treated with anthracycline exclusion criteria: * patients with inflammatory breast disease
determining the clinical utility of using virtual reality headsets to assess visual function in those with glaucoma.

Conditions: Glaucoma

Summary: to validate a new virtual reality (vr) based visual field test against the gold standard clinical perimetry test (humphrey visual field test 24-2).

perimetry (or visual field testing) is a vision test used to evaluate a patient's peripheral vision. it involves a patient fixating on a central target and pressing a button when they see a spot of light in their peripheral vision. it is an important way of deciding whether glaucoma is progressing or not. next generation virtual reality (vr) technologies offer an exciting new way of conducting perimetry in either a clinical or home environment, allowing more affordable and more frequent monitoring of disease progression in glaucoma, and an easier and more comfortable experience for patients. the investigators propose to create a perimetry test using a commercially available head mounted display for vr, and to assess its accuracy in glaucoma patients in relation to standard automated perimetry.

Eligibility criteria:
inclusion criteria: - patients with a clinical diagnosis of glaucoma with repeatable defects on standard automated perimetry. exclusion criteria: * presence of other ocular disease which impacts vision such as age-related macular degeneration or diabetic retinopathy. * any physical limitation that would make the participant unable to place their head in the head-rest to perform humphrey perimetry (eg some patients with arthritic or neck problems are unable to use the headrests of ophthalmic devices). * any cognitive impairment that would limit their ability to perform perimetry or a history of vertigo/dizziness.

Keywords: perimetry virtual reality visual field testing
a systematic investigation of phonetic complexity effects on articulatory motor performance in progressive dysarthria

Conditions: Amyotrophic Lateral Sclerosis; Parkinson Disease

Summary: the goal is to improve the fundamental knowledge about articulatory motor performance in people with lou gehrig's disease (also known as als) and parkinson's disease (pd), in order to develop more sensitive assessments for progressive speech loss, which may lead to the improved timing of speech therapies.

the long-term goal is to optimize dysarthria assessment by improving the early detection and tracking of articulatory performance in progressive dysarthrias. the short-term goal of the proposed cross-sectional study is to focus on als and pd and quantify articulatory kinematic performance as a function of phonetic complexity, which is experimentally manipulated based on theoretical principles of speech motor development. the research strategy is to use 3d electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in 15 talkers each with preclinical, mild, and moderate dysarthria, relative to 45 controls. the central hypothesis is that as dysarthria severity increases the discrepancy in articulatory performance, indexed by movement speed, distance, coordination, and variability, between people with dysarthria and typical controls will significantly increase at a lower phonetic complexity level.

Eligibility criteria:
inclusion criteria: 1. may or may not have a neurological impairment. 2. age range of 19-90 years. 3. male or female. 4. provide written consent before any study specific procedures are performed. 5. have ability to comply with basic instructions. 6. monolingual english speaker. 7. have ability to partake in a 90 minute data collection. exclusion criteria: 1. any speech, language, cognition, or hearing impairment prior to diagnosis of a neurodegenerative disease. 2. anyone not appropriate for study participation, as deemed by the principal investigator.

Keywords: dysarthria speech motor performance speech motor control speech kinematics
a case-control study of costa rican adults with myocardial infarction

Conditions: Myocardial Infarction, Acute

Summary: this observational case-control trial sought to identify and characterize different exposures associated with nonfatal acute myocardial infarction in costa rican adults. exposures assessed included dietary variables and adipose tissue fatty acids.


Eligibility criteria:
inclusion criteria: * cases were eligible if they met the world health organization criteria for mi exclusion criteria (cases): * died during hospitalization * were 75 years or older on the day of their first mi * were physically or mentally unable to answer the questionnaire * had a previous hospital admission related to cardiovascular disease exclusion criteria (controls): * ever had an mi * were physically or mentally unable to answer the questionnaire
comparing monofocal iols in highly myopic cataract patients

Conditions: Cataract

Summary: comparison of postoperative outcomes in patients with high myopia undergoing cataract surgery implanted with extended depth of focus intraocular lens (icb00) and monofocal intraocular lens (zcb00)

in this study, we aim to compare the visual outcomes and quality of life between highly myopic patients with cataracts who receive implantation of extended depth of focus (edof) intraocular lenses (icb00) and monofocal intraocular lenses (zcb00). this is a case-control study, planning to recruit 64 highly myopic patients with cataracts, aged between 40 and 70, with 32 in each group. the primary endpoints of the study are the best-corrected visual acuity (bcva) and defocus curve at 6 months postoperatively. secondary endpoints include uncorrected visual acuity (ucva), contrast sensitivity, intraocular pressure, and assessments of patient satisfaction and quality of life. these will be evaluated using standardized questionnaires such as the vf-14, the prsiq spectacle dependency scale, and reading speed tests to quantify changes in vision-related quality of life. patients will undergo comprehensive ophthalmic examinations preoperatively and at 6 months postoperatively, including slit-lamp anterior segment examination, fundus examination, corneal topography, and intraocular pressure testing. additionally, questionnaires will be used to assess patients' subjective satisfaction with visual improvement and spectacle needs in daily life. all data will be statistically analyzed to compare the effects of the two types of intraocular lenses. continuous variables will be analyzed using t-tests or mann-whitney u tests, and categorical variables will be analyzed using chi-square tests. the level of statistical significance is set at p\<0.05. through this study, we hope to determine whether the use of edof intraocular lenses provides better visual outcomes and quality of life compared to monofocal intraocular lenses in highly myopic patients with cataracts. the results of this study will provide a more scientific basis for the choice of intraocular lenses in clinical practice.

Eligibility criteria:
inclusion criteria: * 1: the patients are between 40 and 70 years old. 2: ocular axis \> 26mm 3: able to understand, cooperate and complete all follow-up. exclusion criteria: * 1: moderate and severe dry eye 2: there is macular degeneration complicated by high myopia. 3: combined with other ophthalmic diseases 4: previous history of ophthalmic surgery. 5: there are intraoperative or postoperative complications.
evaluate the diagnostic value of puncture biopsy for ppl under the guidance of navigation and radial ebus: a real-world study

Conditions: Lung; Nodes

Summary: the study is designed to evaluate the safety and effectiveness of biopsy forceps combined with puncture biopsy for the diagnosis of peripheral pulmonary nodules under the guidance of augmented reality navigation system combined with radial endobronchial ultrasound (r-ebus), and to explore the factors influencing the diagnosis rate.

the study will last for no longer than 12 months. patients will be first screened, and only after meeting all the inclusion criteria, not meeting any exclusion criteria, and signing the informed consent, could they be enrolled in the group to receive forceps biopsy combined with puncture biopsy to sample the target nodules. the primary endpoint is the combined diagnostic yield of forceps biopsy and puncture biopsy. the secondary endpoints include the success rate of biopsy, the operation time of the bronchoscope and so on.

Eligibility criteria:
inclusion criteria: * 1. age ≥ 18 years old; 2. chest ct shows that the peripheral lung noduleswith uncertain diagnosis are adjacent or far from the airway, and/or are difficult to obtain samples by routine biopsy as assessed by investigators; 3. understand the research and sign the informed consent form. exclusion criteria: * 1. contraindications for bronchoscopy; 2. severe cardiopulmonary dysfunction and other diseases that may significantly increase the risk of surgery; 3. bronchoscopy shows visible intra-airway nodules above the 3rd bronchus; 4. the investigator believes that the patient has other conditions that are not suitable for inclusion in this study.

Keywords: peripheral pulmonary nodules biopsy
a study of postprandial hyperglycemia in participants with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: this study is looking at whether high blood glucose levels after a meal affect arterial stiffness more or less than low blood glucose levels, and whether certain cardiovascular markers influence the outcome of this.


Eligibility criteria:
inclusion criteria: * are diagnosed with t2dm (according to the american diabetes association classification \[american diabetes association 2006\]) and on insulin therapy for at least 6 months. * have not smoked in the last 12 hours prior to the study visit. * have albuminuria but normal kidney function or normal uaer \[uaer \< 20 micrograms per minute (mcg/min) or \< 30 milligrams/24 hours (mg/24h), respectively\]. participants with or without albuminuria but normal kidney function will be matched for age and body mass index (bmi). * participants have been judged by the investigator to be reliable to keep appointments for clinic visits and all tests and examinations required by the protocol. * each participant must understand the nature of the study and must sign an informed consent document (icd). healthy participants are eligible to be included in the study only if they meet all of the following criteria: * healthy participants 45 to 70 years of age, matched for age and bmi, who have not smoked in the last 12 hours prior to the study. * normal glucose tolerance and normal uaer (uaer between \< 20 μg/min in the overnight urine collection or \< 30 mg/24h in the 24-h urine collection). * healthy participants have been judged by the investigator to be reliable to keep appointments for clinic visits and all tests and examinations required by the protocol. * each healthy participant must understand the nature of the study and must sign an icd. exclusion criteria: participants/healthy participants will be excluded from the study if they meet any of the following criteria: * have had a cardiovascular event \[stroke, myocardial infarction (mi), coronary artery procedure (by-pass surgery or angioplasty), limb amputation due to ischemia, peripheral vascular disease\] or coronary heart disease confirmed by exercise test or scintigraphy. * have arrhythmias. * have an acute infection. * are currently enrolled in, or discontinued within the last 30 days from, a clinical trial involving an investigational drug or device or off-label use of a drug or device (other than the study drug/device used in this study), or concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study. * are unwilling or unable to comply with the use of a data collection device to directly record data from the participant.