Kornimate/medical-research-clean huggingface dataset:
study of axitinib in patients with unresectable hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to evaluate the potential role of axitinib (ag-013736) in the treatment of unresectable/metastatic hepatocellular carcinoma (hcc)

this is a phase ii study of an investigational drug, axitinib following prior antiangiogenic therapy in patients with advanced hepatocellular carcinoma. hepatocellular carcinoma (hcc) is a primary cancer of the liver. angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing vessels. a tyrosine kinase is an enzyme that can inhibit angiogenesis. in this study, patients with advanced hcc who have failed prior antiangiogenic therapy, will receive axitinib in cycles of 4 weeks. axitinib is an oral, potent and selective inhibitor of angiogenesis. this study will evaluate the response rate of hcc following treatment with axitinib as well as safety, feasibility, overall survival of patients, progression-free survival, and quality of life in persons with unresectable hcc. the study also compares response determined by recist to response determined by choi criteria.

Eligibility criteria:
inclusion criteria: * unresectable and/or metastatic hepatocellular carcinoma * previous treatment with tyrosine kinase inhibitors or antiangiogenic drugs * life expectancy of ≥12 weeks * at least one tumor lesion * at least 2 weeks since the end of prior systemic treatment * no evidence of pre-existing uncontrolled hypertension * ecog 0 or 1 * adequate organ function * not appropriate for curative therapy * child a or b7 cirrhosis * clip score ≤ 4 exclusion criteria: * received any other systemic therapy for hepatocellular carcinoma within 2 weeks prior to treatment * major surgery \<4 weeks or radiation therapy \<2 weeks of starting the study treatment * previous or concurrent cancer that is distinct in primary site or histology from hepatocellular carcinoma * severe acute or chronic medical or psychiatric condition * need for treatment with prohibited drugs * has received local therapy to all measurable lesions * stage b8 or higher liver cirrhosis * ascites refractory to diuretic therapy * clinically significant ecg abnormality

Keywords: hepatocellular carcinoma advanced hepatocellular carcinoma liver cancer axitinib ag-013736
blood types in children with covid-19

Conditions: COVID-19 Infection

Summary: it is speculated that in adult patients with covid-19 blood type a is associated with the worst outcome, while blood type o is associated with mild symptoms.to our knowledge, there has been no such a study investigated abo and rhesus (rh) blood group types in children with covid-19 infection yet. therefore, the study aimed to examine if such a correlation exists in children infected with covid-19.


Eligibility criteria:
inclusion criteria: * the study period consisted between march 2020 and december 2020 * children with a documented positive covid-19 nasal smear real-time reverse-transcriptase polymerase chain reaction (pcr) assay were included. exclusion criteria: * patients who had a past medical history of any chronic illness (related to respiratory, cardiology, immunology, neurology, metabolic, etc) were excluded.

Keywords: covid-19 abo blood group infection risk
patupilone activity in advanced/metastatic hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: this study will evaluate the safety, efficacy, and activity of patupilone in patients with advanced unresectable and/or metastatic hepatocellular carcinoma based on tumor response using modified recist criteria.


Eligibility criteria:
inclusion criteria: - hepatocellular carcinoma patients with at least 1 previously un-irradiated, measurable lesion without any systemic single agent or combination chemotherapy. previous local therapy is allowed. exclusion criteria: additional protocol-defined inclusion/exclusion criteria apply.

Keywords: advanced unresectable metastatic hepatocellular carcinoma liver cancer
mindfulness training in u.s. army cohorts

Conditions: Psychological Stress; Anxiety; Post Traumatic Stress Disorder; Depression; Cognitive Change

Summary: this project aims to contextualize delivery of mindfulness training to u.s. army personnel, evaluate its effectiveness on measures of executive functions and psychological well-being, and determine best practices for its delivery.

background: an individual's success in the u.s. army relies on many factors including the integrity of executive functions (efs). efs comprise a complex, multi-faceted brain system necessary to pay attention, overcome habitual and automatic behaviors, regulate mood, and ensure that current behavior is in line with short and long-term goals.yet, protracted periods of high uncertainty, high demands, and high stress can lead to decreases in the efficiency and availability of efs. given the high demands and psychological vulnerabilities that u.s. army personnel may face, it is critical to provide them with training programs to protect against degradation of efs (particularly attention and working memory) over high-stress, high-demand intervals. prior research on mindfulness training (mt) in civilians and military servicemembers showed that mt can effectively protect against degradation in attention and working memory and benefit psychological well-being over high-demand intervals. problem: while being successful, prior mt programs required a considerable amount of time dedicated to training (e.g., 24-hour training) and it is challenging to integrate these long programs into the busy schedule of the u.s. army personnel. to accommodate the time constraints, the principal investigator together with a mindfulness expert developed a short-form mindfulness training program contextualized for the u.s. army; the program consists of 8-hour training and is known as mbat, mindfulness-based attention training. project goal: the present study aims to investigate the best practices for delivery of a short-form mindfulness training to u.s. army cohorts. specifically, the present study will examine the best delivery structure for the mbat by comparing mbat course delivered in 2 weeks vs. 4 weeks.

Eligibility criteria:
inclusion criteria: * english-speaking * u.s. army personnel * able to understand and provide signed informed consent exclusion criteria * non-controlled sever medical disease that might interfere with the performance in the study * any other condition that the investigator might deem problematic for the inclusion of the volunteer in a training study of this nature
study to evaluate the efficacy and safety of filgotinib in the treatment of perianal fistulizing crohn's disease

Conditions: Fistulizing Crohn's Disease

Summary: the primary objective of this study is to evaluate the efficacy of filgotinib as compared to placebo in establishing combined fistula response at week 24. participants will have the option to enter a separate long-term extension (lte) study (gs-us-419-3896; nct02914600) if they meet eligibility requirements.


Eligibility criteria:
key inclusion criteria: * males or non-pregnant, non-lactating females, ages 18 to 75 years, inclusive based on the date of screening visit * diagnosis of crohn's disease (cd) with a minimum duration of cd of at least 3 months * has draining perianal fistulae as a complication of cd, confirmed by magnetic resonance imaging (mri) at screening * previously demonstrated an inadequate clinical response, loss of response to, or intolerance of at least 1 of the following agents (depending on current country treatment recommendations/guidelines): * antibiotics and/or * immunomodulators and/or * tumor necrosis factor α (tnfα) antagonist * is willing and able to undergo mri per protocol requirements * is willing and able to undergo flexible sigmoidoscopy per protocol requirements key exclusion criteria: * presence of current rectovaginal anovaginal or enterovesicular fistulae * presence of ulcerative colitis (uc), indeterminate colitis, ischemic colitis, fulminant colitis, or toxic mega-colon * history of total proctocolectomy, total colectomy, presence of ileostomy or colostomy, or likely requirement for surgery during the study * use of any prohibited concomitant medications as described in the study protocol * active tuberculosis (tb) or history of latent tb that has not been treated note: other protocol defined inclusion/exclusion criteria may apply.
add-on sodium nitroprusside to treatment as usual in schizophrenia

Conditions: Schizophrenia

Summary: in spite of the numerous studies on schizophrenia, its etiology and physiopathology remain unknown. evidence suggests a possible implication of nitric oxide (no) in schizophrenia. no is a gas with unique chemistry and influences the release of neurotransmitters, learning, memory and neurodevelopment. recent studies that investigated the role of no in patients with schizophrenia found evidence that points to a disruption in no-mediated neurotransmission in schizophrenia. accordingly, we believe that the administration of sodium nitroprusside, an no donor, will ameliorate schizophrenia symptoms.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of schizophrenia * patients in an acute psychotic episode requiring full hospitalization exclusion criteria: * significant medical conditions (heart, kidney, liver, thyroid or neurological diseases, hypovitaminosis b12, hyponatremia) * pregnancy * breastfeeding * previous hypersensitivity to sodium nitroprusside * dsm-iv diagnosis of drug abuse or dependence

Keywords: schizophrenia nitric oxide sodium nitroprusside
specific immunotherapy for allergic child

Conditions: Allergic Rhinitis; Allergic Asthma; Grass Allergy

Summary: the recent interest that the specific immunotherapy (its) has aroused is due to the positive potential role that could be played, in particular in the forms of allergic asthma, because this method constitute the only intervention (unlike that pharmacologic) able to act on the same causes of the disease, altering the natural history. to achieve this the investigator has tried to use the specific subcutaneous immunotherapy (scit), to which there are studies that, with scientific rigor, have demonstrated the benefits.

the investigator proposes to compare, in children with allergic rhinitis and / or allergic asthma to grasses, the pain caused by the administration of the specific immunotherapy (its) via epicutaneous with autoinjector (injex) pressure without needle vs. the traditional subcutaneous immunotherapy (scit).

Eligibility criteria:
inclusion criteria: * written informed consent from both parents / legal guardian; * of both sexes; * between the ages of 5 to 18 sensitized to grasses awareness for grasses will be established with prick test; * rhinitis established according to the aria (allergic rhinitis and its impact on asthma) guidelines and / or stage 1 or 2 asthma according to gina classification (global initiative for asthma) * it may, or not, be going on its with s.c. administration exclusion criteria: * children under age 5 and age\> 18 years; * autoimmune diseases and immunodeficiencies; * neoplasms; * severe psychological problems; * treatment with β-blockers; * poor compliance, including language training; * severe asthma uncontrolled by medication or irreversible airway obstruction (fev1 less than 70% of the predicted value); * severe cardiovascular diseases in which may be hazardous in the administration of adrenaline

Keywords: grass allergy allergic rhinitis allergic asthma paediatric
binaural beat stimulation to improve patient outcome after surgery and anesthesia

Conditions: Preoperative Anxiety; Perioperative Complication

Summary: we plan to evaluate the potential of binaural beat stimulation as a cost-effective tool to improve perioperative patient outcome. preoperative anxiety and postoperative neurocognitive disorders are two major issues patients have to deal with in the perioperative period. in this context, preoperative stress and anxiety are independent risk factors for postoperative neurocognitive disorders. the primary goal of our proposed study therefore is to reduce preoperative anxiety by stimulating patients with binaural beats. as binaural beats might also entrain brainwaves, the secondary goal of the study is to investigate whether binaural beats can induce alpha oscillatory activity during emergence from anesthesia. this type of oscillation has been demonstrated to be protective for postoperative neurocognitive disorders and might therefore complement the effects of preoperative anxiety reduction.


Eligibility criteria:
inclusion criteria: * fluent in german (munich) or portuguese (porto) * scheduled for elective minor or intermediate risk procedure exclusion criteria: * asa status 4 * history of drug abuse * pre-existing neurocognitive or psychiatric disorders * auditory impairments, vision diseases or other diagnosed cognitive impairments
narrow qrs ischemic patients treated with cardiac resynchronization therapy (narrow crt)

Conditions: Heart Failure, Systolic

Summary: current recommendations require a qrs duration of ≥120ms as a condition for prescribing cardiac resynchronization therapy (crt). this study was designed to test the hypothesis that patients with heart failure of ischemic origin, current indications for defibrillator implantation and qrs \<120ms may benefit from crt in the presence of marked mechanical dyssynchrony.


Eligibility criteria:
inclusion criteria: * nhya class ii-iii heart failure * ischemic cardiomyopathy * ejection fraction of 35% or less * qrs interval of 120ms or less * evidence of mechanical dyssynchrony as measured on echocardiography exclusion criteria: * conventional indication for cardiac pacing * persistent atrial fibrillation * life expectancy lower than 1 year

Keywords: crt heart failure narrow qrs dyssynchrony
effect of reslizumab in chronic rhinosinusitis

Conditions: Sinusitis

Summary: the purpose of this study is to determine whether reslizumab is effective for the treatment of chronic sinusitis.


Eligibility criteria:
inclusion criteria: 1. written informed consent 2. willingness and ability to comply with the requirements of the study 3. female or male patients ages 18-75 at the time of screening 4. a diagnosis of chronic rhinosinusitis according to the clinical practice guideline (update) of the american academy of otolaryngology - head and neck surgery 5. elevated blood eosinophils 6. significant findings on computed tomography (ct) scan exclusion criteria: 1. unable to sign informed consent form 2. a woman that is pregnant or nursing a child 3. known hypersensitivity to reslizumab 4. active cigarette smoking in the year prior to screening 5. known underlying immunodeficiency 6. history of alcohol or drug abuse in the year prior to screening other criteria may apply. please contact the investigator for more information

Keywords: sinusitis, rhinitis, rhinosinusitis, chronic
pst linkage based analysis in the family of more than two members with type 1 diabetes in taiwan

Conditions: The Genetic Variation of Type 1 Diabetes

Summary: the purpose of this study is to explore the susceptible genes for type 1 diabetes in taiwan through the new genetic study methods.

as an unclear autoimmune disorder, the pathogenesis of type 1 diabetes (t1d) remains elusive. among all the methods for studying diseases pathophysiology, genetic approach has valuable capability as being both hypothesis-testing and hypothesis-generating. although geo-epidemiological studies show relatively higher prevalence of t1d in caucasians than in asians, whether genetic factors identified in t1d of caucasians are essential for t1d in asians is not yet clarified. although the human leukocyte antigen (hla) genotype variants have been reported to be associated with t1d, the odds ratio (ors) is relatively low in taiwan as comparing with western countries, some families are indeed more than one child with t1d. however, the genetic linkage study in t1d is still limited in taiwan that hampered the drug development or research in t1d. therefore, we intend to explore the susceptible genes for t1d of taiwan in this study, which will provide further researcher directions for this disease.

Eligibility criteria:
inclusion criteria: 1. type 1 diabetes on the criteria of the american diabetes association with a very low c-peptide level (\<0.35 ng/ml) with or without the experience of diabetic ketoacidosis. 2. the subjects whose four grandparents are of chinese han origin exclusion criteria: 1. patients with ages of onset more than 35 years are excluded. 2. the families having any member with known possible type 2 diabetes
bulking agent versus electrostimulation therapy in anal incontinence

Conditions: Fecal Incontinence

Summary: randomized trial with a estimated number of 60 patients with mild or moderate anal incontinence at the clinic physiology of the hospital das clínicas of the medical school of the university of são paulo (hc-fmusp). * exclusion criteria: symptoms of anal incontinence for less than six months, with severe anal incontinence, associated external anal sphincter damage, past pelvic radiotherapy, evidence of perineal sepsis, rectal prolapse, anorectal cancer, inflammatory bowel disease, malignant disease congenital formation, scleroderma, parkinson's disease, immunosuppression and ongoing gestation. in addition, those patients who do not agree to participate in the survey will be excluded. * the study will have 4 phases: preoperative, surgical, recent postoperative and later postoperative

* prospective randomized trial * estimated number of 60 patients with mild or moderate anal incontinence with isolated anal sphincter muscle damage or evidence of anal incontinence without verification of anatomical damage to the anorectal sphincter complex with dysfunction or inadequate action of the internal anal sphincter accompanied at the outpatient clinic physiology of the hospital das clínicas of the medical school of the university of são paulo (hc-fmusp). * exclusion criteria: symptoms of anal incontinence for less than six months, with severe anal incontinence, associated external anal sphincter damage, past pelvic radiotherapy, evidence of perineal sepsis, rectal prolapse, anorectal cancer, inflammatory bowel disease, malignant disease congenital formation, scleroderma, parkinson's disease, immunosuppression and ongoing gestation. in addition, those patients who do not agree to participate in the survey will be excluded. * the study will have 4 phases: preoperative, surgical, recent postoperative and later postoperative

Eligibility criteria:
inclusion criteria: * moderate fecal incontinence exclusion criteria: * severe fecal incontinence * pelvic radiotherapy

Keywords: fecal incontinence, anorectal manometry, bulking agents
stress management therapy for meniere's disease

Conditions: Meniere's Disease; Stress

Summary: attacks in meniere's disease, characterized by vertigo and hearing loss, are well known to occur repeatedly under stressed environment. hitherto, its pathology was revealed to be inner ear hydrops through human temporal bone studies in 1938. for the pathogenesis of inner ear hydrops resulting in meniere's attacks, plasma vasopressin elevation due to stress and v2 receptor overexpression in the inner ear could be essential as a basis of this disease. in the present study, we'd like to find the effective and feasible way to reduce plasma vasopressin level in patients with meniere's disease.

background: for the pathogenesis of inner ear hydrops resulting in meniere's attacks, plasma vasopressin elevation due to stress and v2 receptor overexpression in the inner ear could be essential as a basis of this disease. in the present study, we'd like to find the effective and feasible way to reduce plasma vasopressin level in patients with meniere's disease. methods: we estimate to enroll 200 meniere's patients to four study groups in a randomized controlled trial at osaka university hospital during this study period 2010-2015. patients are diagnosed as meniere's patients according to the 1995 aao-hns criteria. group-i consists of 50 patients who receive just traditional oral intake medication including anti-diuretics. group-ii consists of 50 patients who receive both medication and water intake (at least 2.0 litters per day). group-iii consists of 50 patients who receive both medication and tympanic tubing (under local anesthesia). group-iv consists of 50 patients who receive both medication and sleep well (regular sleep program under dark everynight). additional factors to medication in each group are supposed to have influence on hypothalamus. we follow up all these patients at least 12 months and evaluate stress, psychological and dizziness conditions using a couple of questionnaires. we also examine changes in plasma vasopressin level of patients in each group. estimated results: through this study, we can understand the most effective and feasible way to reduce plasma vasopressin level in patients with meniere's disease. much more meniere's patients may be rescued without invasive surgery.

Eligibility criteria:
inclusion criteria: * patients diagnosed as meniere's patients according to the 1995 aao-hns criteria are included into this study. exclusion criteria: * patients refused our prepared four kinds of treatments are excluded from this study.

Keywords: meniere's disease stress management vasopressin v2 receptor water intake tympanic tubing regular sleep under dark
estimation of pentraxin3 and pgingivalis levels in patients with knee joint and gum diseases

Conditions: Rheumatoid Arthritis; Chronic Periodontitis

Summary: periodontitis and rhematoid arthritis are chronic inflammatory diseases which share common risk factors the purpose of this study is to determine if pentraxin 3 and porphyromonas gingivalis levels play an important role in the progression of both the diseases.

periodontal disease progression might play a significant role in the severity and outcome of systemic diseases like rheumatoid arthritis. pentraxin3 is a newly discovered inflammatory biomarker. it is a member of acute phase proteins and it has been observed from previous studies that plasma pentraxin3 levels have increased with increasing severity of cardiac and renal problems. porphyromonas gingivalis proteinase is responsible for the epitope development in rf-fc region these proteinases are important virulence factors which lead to degradation of host tissue. porphyromonas gingivalis is also a key periodonto pathogen. thus the aim of this study is to compare the plasma pentraxin3 and p.gingivalis levels in patients with periodontitis and rheumatoid arthritis.

Eligibility criteria:
inclusion criteria: 30 patients with rheumatoid arthritis and periodontitis 30 patients with chronic periodontitis only 30 healthy subjects patients with six positive diagnostic criteria for ra,morning stiffness,at least three areas of swollen joints,arthritis of hand joints,symmetric arthritis,rheumatoid nodules,serum rheumatoid factor. for periodontal findings patients aged ≥30yrs,attachment level ≥6mm,at least 20 teeth should present, ≥ 2 sites with pocket depths ≥ 5mm exclusion criteria: patients with aggressive periodontitis, smokers, with gross oral pathology or tumors, with any systemic disorder other than rheumatoid arthritis