Kornimate/medical-research-clean huggingface dataset:
pc-300 tea effect on triglyceride levels

Conditions: Hypertriglyceridemia

Summary: herbal medicine represents an alternative for treating dyslipidemia. the aim of this project was to evaluate the pc-300 tea (eryngium heterophyllum egelm + amphipterygium adstringens) against hypertriglyceridemia. baseline samples of serum total cholesterol and triglycerides were obtained and measured again after 1 month of treatment with the following two alternatives: 1) pc-300, one cup half an hour before eating, and 2) bezafibrate 200 mg/d.

it was a descriptive, prospective, longitudinal, and comparative clinical study developed at ciprés grupo médico s.c. (cgm), toluca, mexico, from january 2014 to december 2014. patients with hypertriglyceridemia were invited to participate in the study. voluntary subjects were assigned sequentially into two treatment groups: 1) fibrate (bezafibrate) 200 mg/day, and 2) pc-300 tea, one cup half an hour before eating. patients were measured (m) and weighed (kg) (obi, méxico). body mass index (bmi) was calculated as weight (kg) divided by height (m) squared. blood pressure was measured with a calibrated sphygmomanometer (welch allyn, usa) after 5 min of rest. all of the patients were given a low lipid diet. calculated kcal were based on ideal weight minus 200 kcal/day if overweight. results were expressed as mean ± standard deviation (sd). differences between initial vs. final values were compared with the mann-whitney u test. the normality hypothesis was tested using the kolmogorov-smirnov test. a p value of \<0.05 was considered significant. all tests were performed with the spss ver. 23 statistical software program.

Eligibility criteria:
inclusion criteria: * patients with hypertriglyceridemia, aged \>18 years and with an educational level at least of primary school. exclusion criteria: * patients with hepatic disease and those missing an appointment during the study.

Keywords: eryngium heterophyllum amphipterygium adstringens tea
spatio-temporal parameters of walking in patients hospitalized in acute geriatrics

Conditions: Difficulty Walking

Summary: the prevalence of walking disorders in the elderly is high. these can lead to falls which represent a major public health issue in terms of hospitalization, morbidity and cost. numerous studies analyzing the link between spatio-temporal parameters of gait and fall have already been carried out, but most have been carried out in a population of elderly patients living at home and having no or few comorbidities. very few studies have been carried out in a population of frail elderly people, with multiple comorbidities or multiple medication, which is the case with most patients hospitalized in acute geriatrics. the objective of the study is to evaluate the spatio-temporal parameters of walking using the gaitrite® mat in patients hospitalized in acute geriatrics and to compare them between a population of falling patients and a population of patients. no faller.


Eligibility criteria:
inclusion criteria: * subject aged \> 70 years * have been hospitalized in an acute geriatric ward at the university hospitals of strasbourg between 01/06/2019 and 28/02/2020 * have been able to walk on a square surface at least 12 meters long, with or without technical assistance * subject not having expressed, after being informed, his opposition to the reuse of his medical data for scientific research purposes. exclusion criteria: * subject having expressed opposition to participating in the study * non-autonomous subject for transfers and trips * subject under guardianship, curatorship or safeguard of justice

Keywords: difficulty walking elderly person spatio-temporal parameters
studying the modification of attention bias remotely after trauma

Conditions: Post Traumatic Stress Disorder

Summary: the investigators will complete an entirely remote randomized controlled trial (rct) comparing 14 sessions of attention bias modification (abm), attention control training (act), placebo neutral attention training, and a final control condition with daily questions in 1,897 individuals with clinically significant post-traumatic stress symptoms (ptss) (defined as pcl-5 score ≥ 33). to assess effects of the training and control conditions, the investigators will administer tests of threat-related attention bias and variability, and self-report assessments of ptss, depression, anxiety, and perceived stress at baseline, after one and two weeks of training, and at eight-week follow up. the investigators plan to screen and confirm interest from over 3,000 eligible participants over a period of 24 months to enroll and randomize 1,897 participants with the end goal of 1,232 completers (176 per condition).


Eligibility criteria:
inclusion criteria: * aged 18 to 65 years * score at or above 33 on the pcl-5, * able and willing to perform daily smartphone training for two weeks * fluent english comprehension. * owns android or iphone smartphone exclusion criteria: * does not have android or iphone operating system (ios) smartphone running sufficient software (i.e. at least ios 10.1), and is not willing to update * active suicidality.

Keywords: attention bias
physical activity in persons with parkinson's disease

Conditions: Parkinson Disease; Physical Inactivity

Summary: parkinson's disease (pd) is a leading neurodegenerative health condition in sweden and a public health concern. although no cure exists, functional independence and participation in society remain top priorities, and can be achieved through targeted physical activity (pa) interventions. to date, few longitudinal cohort studies have been conducted, using pa as main outcome in therapy research, partly due to the complex nature of predicting and controlling this phenomenon. to help address this knowledge gap, the overall purpose of the future long-term (activpark) study is to enhance knowledge of the evolution of pa behavior, and how it is influenced beyond the disease characteristics using a broad explanatory model, in persons with pd from a diversity of settings in sweden with the aim of prescribing tailored and personalized interventions to enhance functioning, health, and wellbeing throughout the disease progression and recommend potential health care pathway modifications. the investigators have just established an expert group, comprising researchers, healthcare professionals, and pd organisations (including persons with pd) and reached consensus on essential priority clinical therapy research questions on pa and methodological considerations. the next phase entails performing a multicentre feasibility/pilot study, further developing and refining the assessment battery and research questions linked to the improved explanatory model for pa and methodology, to inform the definite larger clinical cohort study.


Eligibility criteria:
inclusion criteria: * diagnosed with parkinson's disease * mild to severe disease severity ( hoehn \& yahr 1-4). exclusion criteria: * none
cytolytic vaginosis multicentre registry

Conditions: Cytolytic Vaginosis

Summary: the goal of this registry is to learn more about cytolytic vaginosis, a little known and controversial condition. the main questions the registry aims to answer are: * what are risk factors of cytolytic vaginosis? * are there defining symptoms of cytolytic vaginosis? * what features on wet mount should be used to diagnosis cytolytic vaginosis? * are baking soda vaginal irrigations an effective treatment for cytolytic vaginosis? * do characteristics of cytolytic vaginosis vary between sites/countries?

cytolytic vaginosis is a largely unknown, debated, and equivocal vaginal condition. it is unclear whether cytolytic vaginosis is a variant of normal vaginal microbiome or should be considered a vaginal dysbiosis condition, similar to bacterial vaginosis. this multicentre registry will enroll women that have signs/symptoms consistent with cytolytic vaginosis to better characterize it. women at participating sites diagnosed with cytolytic vaginosis and that provide consent will be consecutively enrolled in the registry. the registry will capture data on risk factors, symptoms, test results (eg, wet mount) and treatment outcomes.

Eligibility criteria:
inclusion criteria: * vaginitis symptoms * predominately lactobacilli or/and elongated lactobacilli on wet mount * cytolysis on wet mount exclusion criteria: * unable to consent or decline consent * pregnant * positive for yeast (culture or pcr)

Keywords: vaginitis lactobacillus wet mount vaginal microbiome fragmented epithelial cells vaginal discharge
endothelial cell loss in pseudophakic patients receiving a paul glaucoma drainage device with its tube inserted in the anterior versus posterior chamber: a randomized controlled trial

Conditions: Glaucoma

Summary: rationale: glaucoma is a group of diseases characterized by progressive neuropathy of the optic nerve associated with visual field loss. current glaucoma management aims to preserve visual function throughout life by reducing the intraocular pressure. this can be achieved by medical therapy or by surgical procedures such as implantation of a glaucoma drainage device (gdd). conventionally, the tube of such a device is positioned in the anterior chamber (ac). unfortunately, the presence of the tube in the ac may have a significant negative impact on the number of endothelial cells of the cornea and may even lead to corneal decompensation. alternatively, the tube can be positioned in the posterior chamber (i.e. behind the iris). in this study, both procedures will be compared. objective: primary: to determine the loss of corneal endothelial cells after implantation of a paul gdd with its tube either anterior or posterior of the iris. secondary: to compare efficacy and safety of both procedures. study design: prospective, randomised, treatment controlled clinical trial. study population: pseudophakic patients with glaucoma who need a gdd. intervention: implantation of a paul gdd with its tube anterior/posterior of the iris. main study parameters/endpoints: endothelial cell loss of the cornea. nature and extent of the burden and risks associated with participation, benefit and group relatedness: at present potential benefits and drawbacks of positioning the paul tube behind the iris are insufficiently known, successful positioning of the tube may require slightly more surgery time and the risk of hyphaema may be higher. it is expected, that in the long run damage to the corneal endothelium is less. risks of study-related assessments are negligible, burden is low, extra time is about 35+15+35+35 minutes (total 2h).


Eligibility criteria:
inclusion criteria: * age \> 18 years * informed consent * pseudophakic * open angle glaucoma, pseudoexfoliation glaucoma, pigment dispersion glaucoma or angle closure glaucoma with sufficiently deep anterior chamber * endothelial image at baseline of fair or good quality exclusion criteria: * iridocorneal endothelial syndrome or posterior polymorphous dystrophy * eyes with a history of penetrating trauma * eyes with a history of (intra)ocular surgery other than uncomplicated cataract surgery * eyes with corneal disease * synechiae posterior * pregnant and lactating women
(1,3)-béta-d-glucan levels at diagnosis of juvenile idiopathic arthritis and its correlation with activity's disease : a cohort sudy

Conditions: Juvenile Idiopathic Arthritis

Summary: juvenile idiopathic arthritis (jia) is the most common pediatric rheumatic disease of childhood. most children still experience prolonged periods of active disease, however, there is still lack of effective and specific markers for early diagnosis of relapse. the pathogenesis of jia is thought to be the result of a combination of host genetic and environmental triggers and the microbiota is a potential contributing factor to the development of the disease. (1-3)-ß-d-glucan (bdg), a component of most fungal cell walls, possess immunomodulatory activities. latest studies demonstrate that it acts as a trigger for autoimmune arthritis in adult. however the relation with jia is not clearly defined. the objective of this study was to evaluate the (1,3)-béta-d-glucans level in patients with jia and whether higher serum bdg levels are correlated with jia activity of disease, comparatively with usual markers.


Eligibility criteria:
inclusion criteria: * all patients under the age of 18 years with jia's disease * followed at the chu amiens (french university hospital) * signed parent consent form exclusion criteria: * lack of consent from parents or patient

Keywords: juvenile idiopathic arthritis (1,3)-beta-d-glucan children inflammatory status intestinal microbiota activity od the disease
blood donor cvd 5000

Conditions: Risk Reduction

Summary: this is an open-label, non-randomized study. volunteers will be vaccinated with the typhoid oral vaccine, vivotif. vivotif has been licensed by the food and drug administration (fda) for travelers to developing countries. volunteers will also be asked to provide blood, saliva, and stool specimens over a follow-up time period of up to eight years. the specimens obtained in this clinical research study will be used to further the investigator's understanding of the protective immunological mechanisms that can be elicited systemically and may be applicable to other enteric pathogens.


Eligibility criteria:
inclusion criteria: * age 18 years and older * good general health as determined by a screening evaluation within 28 days before blood donation * informed, written consent exclusion criteria: * history of any of the following medical illnesses: * diabetes * cancer in past 5 years (except for basal cell carcinoma of the skin and cervical carcinoma in situ) * heart disease (hospitalization for a heart attack, coronary artery bypass graft, arrhythmia, or syncope, within past 5 years. current symptoms of heart disease - dyspnea, angina, orthopnea) * recurrent infections (more than 3 hospitalizations for invasive bacterial infections such as pneumonia or meningitis) * current drug or alcohol abuse * active ulcer disease or ongoing intestinal condition * treatment for anemia in last 6 months * currently being treated with anti-malarial drugs * any of the following laboratory abnormalities detected during medical screening: * wbc \ 1.09 x uln * hemoglobin \ 1.18 x uln (women) or \ 1.18 x uln (men) * platelet count \ 1.2 x uln * (for leukopheresis or blood unit donations, the following lab values are exclusionary: * wbc \ 11 x 103/mm3; * hemoglobin \ 18 g/dl * platelet count \ 500 x 103/mm3) * sgot or sgpt \>1.5 times normal * positive serology for hepatitis c or hiv antibody or hepatitis b surface antigen * positive serology for hepatitis b core antibody * poor peripheral venous access for blood donation * positive rpr * other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or interfere with the scientific integrity of study. * positive urine pregnancy test (hcg) on day of vaccination. prior to each blood donation -females with menstrual history consistent with pregnancy. pregnant women will not be enrolled, because immunological changes that occur during pregnancy may interfere with laboratory assays.

Keywords: typhoid
validation of quantitative flow ratio (qfr) - derived virtual angioplasty

Conditions: Coronary Occlusion

Summary: prospective intervention study to assess the accuracy of the predicted qfr-derived virtual angioplasty compared to hyperaemic and non-hyperaemic pressure-wire derived indexes after pci, as well as with qfr post-pci.


Eligibility criteria:
inclusion criteria: * patients submitted to a coronary angiogram with at least one non-left main stable coronary stenosis with pci indication. exclusion criteria: * severe stenosis of the left main coronary artery. * patients admitted with st-elevation myocardial infarction. * culprit lesions in non-st-elevation acute coronary syndromes (nsteacs) patients. * unability to identify the culprit lesion in nste-acs patients.

Keywords: quantitative flow ratio qfr percutaneous coronary intervention
acute tocolysis with terbutaline for suspected fetal distress

Conditions: Nonreassuring Fetal Status

Summary: the trial was to determine the effect of administrating subcutaneous terbutaline prior to emergency caesarean delivery for suspected fetal distress

the trial was a double-blinded, placebo-controlled study using subcutaneous terbutaline for acute tocolysis prior to emergency caesarean delivery in suspected fetal distress. the intervention (subcutaneous terbutaline) was compared to placebo looking at the neonatal and maternal outcomes. the primary outcome was the proportion of babies with neonatal acidosis (based on umbilical artery blood sampling at delivery). other outcome of interest were the mean cord ph and base excess, the apgar score at 5 minutes after delivery, he proportion of babies requiring intubation and admission to the neonatal intensive care unit. the maternal outcomes of interest were the changes in mean arterial pressure (before and after the drug or placebo injection), the maternal heart rate changes, the estimated blood loss, and the hematocrit changes.

Eligibility criteria:
inclusion criteria: * term singleton pregnancy * cephalic presentation * in labour with cervix dilatation \> 4cm and regular uterine contractions of 3 or more 10 min * abnormal fetal heart rate status diagnosed using standard electronic fhr according to nice guideline (2014) * acceptance of participation by the signing of a written consent. exclusion criteria * maternal cardiopathy * hyperthyroidism * abruptio placentae or other placental accidents * hypertensive disease of pregnancy * hyperstimulation with oxytocin * multiple gestation * abnormal fetus planned for conservative management * evidence of intrauterine growth restriction * patient on medication which will interact with terbutaline (tricyclic antidepressants, beta-blockers, diuretics and sympathomimetic medicine).

Keywords: fetal resuscitation acute tocolysis fetal distress cesarean section
radiocontrast media in the pulsed radiofrequency treatment

Conditions: Lumbar Radiculopathy; Pain, Intractable

Summary: pulsed radiofrequency applied to the dorsal root ganglion (drg) is an interventional treatment alternative in the treatment of lumbar radicular pain that does not respond to conservative methods. under intermittent fluoroscopic imaging, the location of the ganglion can be determined by administering contrast media. we consider that determining the localization of the ganglion with this method during pulse radiofrequency application can shorten the procedure time. in this way, we believe that it would help the correct application of the procedure.

although there are many reasons that can lead to low back pain, radicular pain, which is mostly secondary to lumbar disc hernia, is one of the most common pathologies. pulsed radiofrequency applied to the dorsal root ganglion (drg) is an interventional treatment alternative in the treatment of lumbar radicular pain that does not respond to conservative methods and epidural injection treatments. the electrical field created by the application of pulsed radiofrequency (prf) changes the cellular activity in drg neurons. by polarizing cell membranes, reduces nociceptive transmission and contributes to analgesia. in lumbar dorsal root ganglion prf applications, when the targeted point is reached, the position is confirmed by giving motor and sensory stimuli, and the prf application is initiated in the follow-up. however, it is a problem that the drg is not always in the same location, and therefore, time is often lost or even not found while searching with stimulation. under intermittent fluoroscopic imaging, the location of the ganglion can be determined by administering contrast material. we consider that determining the localization of the ganglion with this method during pulse radiofrequency application can shorten the procedure time. in this way, we believe that it would help the correct application of the procedure.

Eligibility criteria:
inclusion criteria: * 18-65 years of age. * lumbar radicular pain * lack of response to conservative methods * l5 nerve root compression due to disc herniation exclusion criteria: * patients younger than 18 and older than 65 * non-radicular low back pain * l5 nerve root compression due to reasons other than disc herniation * those having spondylolisthesis, or transitional vertebra * having an active infection * pregnancy * bleeding diathesis * renal insufficiency

Keywords: pulsed radiofrequency treatment lumbar radicular pain fluoroscopy
iliac crest bone graft harvesting for pediatric pelvic osteotomy

Conditions: Child; Osteotomy

Summary: the iliac crest is one of the most commonly used bone graft sources, especially in pediatric pelvic osteotomy operations for developmental dysplasia of the hip (ddh) and legg-calve-perthes disease. in this study, we aimed to identify the effects of inner side and two-sided approaches for iliac crest bone harvesting on post-surgery ilium growth in children.

autogenous bone grafting is still the gold standard and most effective method for treatment of non-union and bone defects due to congenital disease and infection. despite the development of bone engineering, none of the allogeneic bone products can match the osteoinductive, osteoconductive, and immunogenic properties of autogenous bone. the iliac crest is one of the most harvested sites other than the fibula, ribs, and ulna. an iliac crest bone graft (icbg) can supply a larger amount of cortical and cancellous bone than grafts from other donor sites. pelvic osteotomy is widely used for treating developmental dysplasia of the hip (ddh) and legg-calve-perthes disease. tricortical structural bone such as that in the ilium is needed to stabilize the pelvis after osteotomy, and the anterior and posterior iliac crest are the two most used graft donor sites. when surgery is planned in the prone position, such as that for posterior spinal fusion, surgeons generally prefer to adopt the posterior approach for icbg procedures. in supine position surgeries such as pelvic osteotomy for ddh or legg-calve-perthes disease, surgeons prefer the anterior approach for icbg procedures. there are many studies on iliac bone growth and complications after icbg procedures. most of the studies demonstrated good outcomes and few complications. however, according to our literature review, none of the previous studies used the iliac bone for transplantation in pelvic osteotomy. in this study, we compared the results between an inner table harvest site and an inner-outer table harvest site for icbg used to maintain stability in pelvic osteotomy.

Eligibility criteria:
inclusion criteria: * the patients who performed iliac crest bone graft and pelvic osteotomy at the same time exclusion criteria: * they had a history of pelvic osteotomy or iliac crest bone graft surgery, bilateral hip disease or congenital bone dysplasia, or were lost to follow-up.

Keywords: pelvic osteotomy developmental dysplasia of the hip iliac crest bone graft