Kornimate/medical-research-clean huggingface dataset:
sleep and vascular health study

Conditions: Sleep; Vascular Diseases; Metabolic Disease

Summary: habitual short sleep duration (\< 7 hours/night) increases the risk of cardiovascular disease (cvd) and all-cause mortality. yet most adults, especially emerging adults (i.e., 18-25 years) do not achieve the national sleep foundation recommendation of 7-9 hours of sleep each night. additionally, the american heart association recently included sleep duration in the "life's essential 8". this recent development emphasizes the importance of sleep and the need to advance our understanding of how sleep impacts cardiometabolic health (cmh), particularly in emerging adults, a population whose cvd risk trajectory is malleable. specifically, emerging adulthood is a critical age window when age-related loss of cmh accelerates. based on my previous work and others, both self-reported and objective measures of poor sleep (e.g., duration, variability) are linked to early signs of elevated cvd risk in emerging adults, such as microvascular dysfunction and elevated central blood pressure (bp), which precede the development of hypertension.

the investigators aim to address the knowledge gap on whether sleep extension is a viable strategy to improve cmh in emerging adults with habitual short sleep duration. a prior study demonstrated the feasibility of sleep extension to improve bp and perceived sleepiness in predominantly normotensive emerging adults (18-23 years). even without hypertension, reductions in bp are generally beneficial for cmh. the research hypothesis is that sleep extension (one extra hour in bed per night) will improve cmh and health behaviors in emerging adults who self-report \< 7 hours of sleep per night. the primary aim is to determine if sleep extension is effective in improving bp. investigators will assess cmh after habitual sleep (2 weeks) followed by a 2-week sleep extension intervention in 60 emerging adults (\~30 female).

Eligibility criteria:
inclusion criteria: * 18 - 25 years old * self-report sleeping less than 7 hours a night on average * free from metabolic disease * free from liver disease * free from pulmonary disease * free from cardiovascular disease exclusion criteria: * blood pressure higher than 140/80 mmhg * bmi greater than 35 kg/m2 * use of blood thinners * history of sleeping disorders * no severe food allergies or eating disorders
taekwondo practice in adolescents with attention deficit hyperactivity disorder

Conditions: Attention Deficit Hyperactivity Disorder

Summary: attention deficit hyperactivity disorder (adhd) is one of the most common neuro-developmental/behavioral disorders among adolescents. sport and physical activity seem to play a major role in the development of cognition, memory, selective attention and motor reaction time, especially among adolescents with adhd. in this context, the objective of this study was to investigate the effects of a one and a half year long taekwondo (tkd) intervention on cognitive function in adolescents with adhd.


Eligibility criteria:
inclusion criteria: * adolescents with attention deficit hyperactivity disorder exclusion criteria: * participants with good attentional performance
dance exercise as novel complementary therapy for parkinson's disease

Conditions: Parkinsons Disease

Summary: the purpose of this study is to gather data to see if so-called enriched forms of exercise programs such as dance is more effective in improving balance and quality of life in patients with idiopathic parkinson's disease than regular exercise programs that are currently provided by physical therapists.

comparison of traditional pt to dance in people who have parkinsons disease to measure which is better for gait, balance and qol.

Eligibility criteria:
inclusion criteria: * diagnosis of pd at least 3 years ago * less than 80 years of age * have gait and balance issues exclusion criteria: * diagnosis of pd for less than 3 years * 80 years of age or older * not have gait and balance issues

Keywords: gait, balance, parkinson's disease
a multicenter, dose ranging safety and pharmacokinetics study of arimoclomol in als

Conditions: Amyotrophic Lateral Sclerosis (ALS)

Summary: the primary purpose of this study is to evaluate the safety and tolerability of arimoclomol in als patients following 90 days of dosing. in addition, the amount of arimoclomol in blood and cerebrospinal fluid will be measured.

arimoclomol is a small molecule that upregulates "molecular chaperones" in cells under stress. arimoclomol extends survival by five weeks when given both pre-symptomatically and at disease onset in a mutant superoxide dismutase (sod1) transgenic mouse model of als. furthermore, it has been demonstrated to have neuroprotective and neuroregenerative effects in other rat models of nerve damage. molecular chaperone proteins are critical in the cellular response to stress and protein misfolding. recent data suggest that the sod1 mutation responsible for als in some patients with familial disease reduces the availability of a variety of molecular chaperones, and thus weakens their ability to respond to cellular stress. protein misfolding and consequent aggregation may play a role in the pathogenesis of both the familial and sporadic forms of als. therapeutic agents such as arimoclomol that improve cellular chaperone response to protein misfolding may be helpful in als.

Eligibility criteria:
inclusion criteria: * familial or sporadic als * vital capacity equal to or more than 60% predicted value for gender, height and age at the screening visit * first als symptoms occurred no more than five years prior to screening * must be able to take oral medication exclusion criteria: * dependence on mechanical ventilation
the spanner prostatic stent and patient's quality of life

Conditions: Prostatic Obstruction

Summary: acute urinary retention is considered one of the most common problems in the older age, especially those who have benign prostatic hyperplasia. solving the problem of acute urinary retention using the foley catheter still causes problems at the level of patient movement and the daily exercises. however, with the emergence of a new device, the spanner, investigators believe that many of the above mentioned problems can be resolved. this tool may provide more freedom for the patient.

this research comes up to date with technological innovations in the field of health where investigators want to evaluate the efficacy of a new catheter (the spanner) to reduce the acute urinary retention and to determine whether they are consistent with the daily life of the patient, compared to the foley catheter previously used. the study include all patients with acute urinary retention due to prostatic obstruction. subjects were excluded if they had prior surgery for prostate cancer, had any other urethral or bladder surgery, or if they were at high risk of developing bladder or kidney stones the study will be national community based study conducted in different hospitals in saudi arabia. investigators will test two different types of stents in patients with acute urinary retention for a short period (not exceeding five days), find out the compatibility of these stents with the daily life of the patient and determine their impact on his quality of life using an appropriate questionnaire after each use.

Eligibility criteria:
inclusion criteria: * acute urinary retention due to prostatic obstruction exclusion criteria: * subjects were excluded if they had prior surgery for prostate cancer, had any other urethral or bladder surgery, or if they were at high risk of developing bladder or kidney stones

Keywords: urinary retention foley catheter the spanner quality of life
validity and reliability study of the turkish version of short western ontario rotator cuff index

Conditions: Rotator Cuff Injuries

Summary: the purpose of this study is to examine the psychometric properties of a turkish shortened version of the western ontario rotator cuff index (shortworc).

many of the musculoskeletal diseases that doctors treat every day affect both quality of life and functionality. rotator cuff diseases are highly prevalent shoulder disorders associated with pain and functional limitations. thus, surveys measuring treatment outcomes and activity limitations have become important in clinical research. such scales can be time consuming or impractical for the patient, depending on the areas they evaluate. for this reason, the development of scales focusing on specific areas facilitates evaluations in the clinical environment. the purpose of this study is to examine the psychometric properties the turkish shortworc index, which is designed to focus on a single parameter.

Eligibility criteria:
inclusion criteria: * between the ages of 18-64 * the presence of rotator cuff pathology requiring surgical treatment exclusion criteria: * chronic inflammatory diseases * cervical spine radiculopathy * different structural shoulder problems in the last three months * previous surgery and associated additional pathologies requiring stabilization or other major \*surgery such as superior labral repair * any history of systemic disease * being an athlete

Keywords: validity of results reliability of results
a study comparing the impact of mini-exchange-room and usual care on physical activity and quality of life in peritoneal dialysis patients

Conditions: Physical Activity; Quality of Life

Summary: to compare the effect of mini-exchange-room and usual care on physical activity and quality of life in peritoneal dialysis (pd) patients through a randomized controlled study. a total of 80 incident capd patients with age of 18\~80 years old will be enrolled, who are medically stable and regularly followed up. the one group perform traditional pd procedure (g1), and the other group will utilize disposable mini-exchange-room group (g2). two groups will be followed for 6 months. biochemistry data, types of space for bag exchange, physical activity and quality of life will also be collected for all subjects at the 3rd and 6th month. during the study period, peritonitis episode, acute comorbidity and hospitalization will be recorded. the change of physical activity, quality of life and peritonitis rate will be compared between the two groups.


Eligibility criteria:
inclusion criteria: * the study will be conducted in the division of nephrology, beijing university first hospital. a total of 80 incident capd patients with age of 18\~80 years old will be enrolled, who are medically stable and regularly followed up. informed consent is required for each patient. exclusion criteria: * those who have (1) intolerance to the study protocols, (2) severe and unstable conditions within one month, acute or chronic inflammation disease, (3) high probability (assessed by the recruiting physician) of receiving a kidney transplant or transferring to hd or drop-out due to socioeconomic causes within 6 months, (4) cognitive or psychological dysfunction, communication barrier, and (5) bag exchange by unfixed manipulator, are excluded.

Keywords: mini-exchange-room physical activity quality of life peritoneal dialysis
optimization of mri sequences used in the study of neurodegenerative diseases

Conditions: Memory Disorders

Summary: the inserm neuropresage team has been using mri for more than 20 years in the study of normal ageing and memory pathologies to further the understanding and the characterization of early diagnosis and the cerebral substrates of cognitive deficits in patients, particularly in the context of neurodegenerative diseases. two years ago, a new 3t mri camera was installed at the cyceron centre. it is more efficient and should make it possible to obtain better quality images and/or to reduce the time required to acquire these images. in this context, it seems important to test the different sequences that we classically use in our studies, or that we plan to implement in our next studies (learning and text retrieval fmri task), in order to optimize them, with a view to integrating them in our future studies.


Eligibility criteria:
inclusion criteria: * healthy volunteers of legal age * affiliation with a social security scheme or beneficiary of such a scheme * signing of the protocol informed consent * for women of childbearing age or capacity, a urine pregnancy test before inclusion exclusion criteria: * protected persons in accordance with articles l. 1121-5 to l.1121-8 of the public health code: protected adults, pregnant and nursing women * presence of contraindications to mri examination without contrast agents injection * presence of a chronic neurological or psychiatric condition (including substance use disorder) * history of brain disease (vascular, degenerative, malformative, tumour, or head trauma with loss of consciousness for more than one hour) * current or recent use of medications that may interfere with imaging (psychotropic drugs, antihistamines with anticholinergic action, antiparkinsonian drugs, benzodiazepines including muscle relaxants, long-term steroidal anti-inflammatory drugs, antiepileptic drugs, central painkillers)
thoughts and health - preventing depression in adolescents

Conditions: Depression; Adolescent Development; Mental Disorder, Child

Summary: this study aims to test the feasibility of implementing an icelandic cognitive-behavioral program designed to prevent depression, called "thoughts and health" in a swedish school setting. the investigators will also evaluate whether implementation of the program has an impact on the participating students, regarding both their mental health and their success in finishing junior high school with passing grades.

clinical depression is a crucial problem among adolescents. in eighth grade more than half of all students experience headaches, stomach pain, stress, feeling down, and difficulties sleeping. adolescents affected by depression at a young age are at greater risk of experiencing depressive symptoms as adults, with serious impacts on their quality of life and ability to work. recent reports from the national board of health and welfare have shown that depression is increasing among adolescents and there is now focus on implementing practice-oriented preventative programs for youth. studies by members of our research team have shown that a cognitive-behavioral, developmentally-based intervention program, called "thoughts and health", prevented initial episodes of depression and/or dysthymia in adolescents for up to 12 months after program completion. this study aims to test the feasibility of implementing that program in a swedish school setting, while also collecting and analyzing preliminary results regarding the potential impact of the program on number of students developing depressive symptoms and the number passing junior high school with full grades. this is an intervention study with a control group. students from two swedish junior high schools will be identified as "at-risk" and invited to participate in the program (n=40), while students from two other schools will act as controls (n=40). all participating students will be followed from study start (baseline) and 1, 6, 12, and 18 months after program completion. results will include quantitative clinical measures, qualitative focus group discussions, and students' final grades. two courses of the program will be run over two school years. this study involves close collaboration between academia, primary care, and the community. this is to our knowledge the first study in sweden that employs a longitudinal design to evaluate the effects of a school program aimed at preventing depression in adolescents.

Eligibility criteria:
inclusion criteria: * eight grader (school) * completed childrens depression inventory (cdi) screening * able to understand swedish both orally and written to a level that he/she can complete forms and questionnaires by themselves exclusion criteria: * current or past depression * unable to function in a group session * current psychotherapeutic treatment * past or current suicidal thoughts or attempts

Keywords: depression prevention school
echo-endoscopy biopsy impact on the circulating tumor cell level

Conditions: Cancer of Pancreas

Summary: the aim of this work is to evaluate the impact of endoscopic procedures on the circulating tumoral cells level in order to evaluate the potential effects of an endoscopic procedure in the management of pancreatic tumors.

the study will include 42 evaluable patients suspected of having pancreatic cancer and for whom an echo-endoscopic biopsy (eus-fna) and/or biliary drainage is planned. in these patients, a 6 ml blood sample will be taken from the portal vein before and after the echo-endoscopic biopsy of the pancreatic mass to determine: * the level of circulating tumor cells (ctc) per milliliter of blood, * cytological characteristics of ctcs (isolated, clustered, giant, and clustered including other cell types). a peripheral blood sample will also be taken to evaluate peripheral ctc levels and cytological characteristics before and after biopsy, as well as one month after biopsy. patients will be evaluated every 6 months as part of their follow-up to assess the progression of their pathology and morbidity.

Eligibility criteria:
inclusion criteria: * men and women aged 40-85 years old; * bmi\< 30 kg/m2; * patients suspected of having pancreatic cancer for whom an ultrasound endoscopic biopsy and/or biliary drainage is planned; * affiliation to, or beneficiary of, a social security scheme. exclusion criteria: * woman who is pregnant or likely to become pregnant (without effective contraception) or breastfeeding ; * person in an emergency situation, person of full age subject to a legal protection measure, or unable to express consent; * biliary drainage or attempt at prior biliary drainage outside the center ; * preliminary oncological treatment for pancreatic pathology covered by the study; * clinical and/or image-visible (ct/mri) carcinosis ; * ascites visible on imaging (ct/mri) ; * impossibility to undergo the medical follow-up of the trial for geographical, social or psychological reasons; * contraindications to an endoscopic procedure.
efficacy study of dysport® in the treatment of anal fissure.

Conditions: Anal Fissure

Summary: to evaluate the effect on healing rates of two different prognostic factors in patients treated with dysport® for anal fissure: duration of fissure and dose of study drug


Eligibility criteria:
inclusion criteria: * patients having idiopathic anal fissure in the posterior anal midline * patients having anal fissure present for less than 6 months * patients having symptoms (pain) present for a minimum of 2 weeks and not responding after 2 weeks of standard therapy (diet, laxatives, sitz-bathes) exclusion criteria: * patients having anal fistulas or anal fissure of various causes such as crohn disease, behcet infectious ulceration, anal suppuration, subfissural infiltration, abscesses, acute haemorrhoidal attacks or inflammatory bowel disease * patients having idiopathic anal fissure in the anterior anal midline * patients having lateral or multiple fissures * patients having anal or perianal cancer * patients who underwent previous anal surgery or have cicatricial alterations or post-surgical cicatricial lesions * patients receiving drugs affecting neuromuscular transmission * patients who have received topical anaesthetic within 3 days of injection * patients receiving local treatment by myorelaxing agent * patients receiving prohibited analgesics * patients having bleeding disturbances or currently using coumarin derivates * patients having myasthenia or any genetic muscle disease
natural cycle versus hormone replacement therapy cycle for a frozen-thawed embryo transfer in pgt patients

Conditions: Miscarriage; Frozen Embryo Transfer; Natural Cycle; Hormone Replacement Therapy Cycle; Preimplantation Genetic Screening; Euploid Embryos

Summary: the aim of the current study is to compare miscarriage rates (before 8 weeks) between a true natural cycle (awaiting spontaneous lh surge) and a hormone replacement therapy cycle prior to blastocyst transfer in preimplantation genetic testing (pgt) patients, with biopsy on day 5 of embryonic development. the advantage of performing the study in pgt patients is the exclusion of aneuploidy as a cause of miscarriage.


Eligibility criteria:
inclusion criteria: * bmi under 35 kg/m2 * regular menstrual cycle pattern (i.e. 24-35 days cycle) * first, second and third icsi-pgt cycle * first frozen embryo transfer cycle following a fresh icsi-pgt attempt * pgt with trophectoderm biopsy on day 5 of embryonic development * signed informed consent exclusion criteria: * oligo-amenorrhea * bmi above 35 * contraindications for the use of hormonal replacement therapy

Keywords: frozen-thawed embryo transfer fet natural cycle hormone replacement therapy cycle miscarriage
effect of fish oil on hyperlipidemia and toxicities in children and young adults with acute lymphoblastic leukemia

Conditions: Leukemia, Acute Lymphoblastic

Summary: acute lymphoblastic leukemia (all) is the most common malignant disease among children. treatment results have improved over time due to intensive risk-adapted therapy and the 5-year survival rate is now above 90%. however, the burden of therapy has increased proportionally. many children develop serious acute and chronic side effects, which impact on the patients expected lifespan and impair their quality of life as a result of therapy. treatment with peg-asparaginase and dexamethasone increases the levels of triglycerides and total cholesterol. consequently, the incidence of hyperlipidemia is high during initial all therapy. studies have suggested that hyperlipidemia is a risk factor for development of osteonecrosis, thrombosis and possibly acute pancreatitis. long-chained marine omega-3 fatty acids, found in fish oil, decrease levels of triglycerides and total cholesterol in hyperlipidemic patients. due to the high survival rate, it is of great interest to develop methods to reduce treatment related toxicities. the investigators hypothesise that daily intake of fish oil will prevent development of hyperlipidemia during all treatment phases with dexamethasone and peg-asparaginase compared to placebo and that fish oil intake may reduce the incidence of severe adverse events related to all treatment.


Eligibility criteria:
inclusion criteria: * children (1-17.9 years) and young adults (18-45 years) diagnosed with all, stratified to very-low risk (vrl), intermediate risk low (ir-low) and intermediate risk high (ir-high) in the alltogether protocol. exclusion criteria: * patients diagnosed with all, stratified to high risk (hr) after induction treatment or stem cell transplantation in the alltogether protocol
treatment of patients with major depressive disorder with mk0869 (0869-063)

Conditions: Major Depressive Disorder

Summary: a clinical study to determine the efficacy and safety of mk0869 in the treatment of depression.

the duration of treatment is 8 weeks.

Eligibility criteria:
major depressive disorder
comparison of er,cr:ysgg and diode lasers in second stage implant surgery

Conditions: Postoperative Pain; Soft Tissue Bleeding; Wound Heal

Summary: the study evaluates postoperative pain, intraoperative bleeding and wound healing after second stage implant surgery. submerged implants were exposed with diode laser in group 1 (n=20) and by using er,cr:ysgg laser in group 2 (n=20).


Eligibility criteria:
inclusion criteria: * subject has osseointegrated implants embedded under oral mucosa. * subject undergoes second-stage implant surgery. exclusion criteria: * inadequate keratinized gingiva in the implant site. * localization of the implant site is not possible due to excessive thickness of the oral mucosa

Keywords: diode laser erbium laser second-stage implant surgery