Kornimate/medical-research-clean huggingface dataset:
structural and metabolic determinants of sarcopenia and the efficacy of concentric vs. eccentric exercise training

Conditions: Healthy

Summary: the first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. this project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.


Eligibility criteria:
inclusion criteria: * healthy male volunteers * body mass index 18-30 kg/m2 * aged 18-35 and 65-75 years exclusion criteria: * participation in a formal exercise regime, * a bmi \ 30 kg/m2, * active cardiovascular disease, * taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs, * cerebrovascular disease, * respiratory disease, * metabolic disease, * active inflammatory bowel or renal disease, * malignancy, * recent steroid treatment (within 6 months) or hormone replacement therapy, * clotting dysfunction, * musculoskeletal or neurological disorders, * family history of early (\<55y) death from cardiovascular disease

Keywords: volunteers young (18-30 y) older (65-75 y) age groups
evaluation of the cardiosond electronic stethoscope in the detection of coronary artery disease

Conditions: Coronary Artery Disease

Summary: the study is designed to evaluate the predictive accuracy of the cardiosond digital electronic stethoscope in the detection of coronary artery disease (cad) in patients with and without known disease who are referred to cardiac computed tomography angiography (ct scans).

the cardiosond is a noninvasive medical device which detects heart sounds using ultrasensitive acoustic technology. the cardiosond produces a flow micro bruit score which is used to determine the likelihood of coronary artery disease. the cardiosond exam will be given to patients two times: once prior to administration of vasodilators and potential beta blockade agents as part of the normal cardiac ct angiography protocol and again immediately post ct angiography. no other data will be taken on the patient and the patients involvement in the study will cease after data collection. ct angiography data will be analyzed at a core lab at medstar research institute and withheld from sonomedica until all cardiosond acoustic data is analyzed and flow micro bruit scores are determined. a data review panel lead by the principal investigator will examine the results of both the cardiosond and ct angiography data to determine the comparative accuracy of the cardiosond in detecting cad in the study population.

Eligibility criteria:
inclusion criteria: * willingness to sign an informed consent. exclusion criteria: * inability to provide informed consent * history of prior myocardial infarction, percutaneous coronary intervention (i.e. stents) or coronary artery bypass graft surgery * heart rate over 70 beats per minute post beta blockade * artery calcification resulting in non-diagnostic ct angiographic images * supraventricular or ventricular arrhythmias that would be expected to affect ct angiography image quality (e.g. atrial fibrillation, atrial flutter, ventricular tachycardia, bigeminy and trigeminy). patients with isolated premature atrial contraction and premature ventricular contractions may enroll * any pulmonary condition that would create abnormal physical findings that would interfere with the fidelity of the cardiac sound recordings (e.g. obstructive pulmonary disease, such as asthma or copd, with audible wheezing) * presence of audible aortic or pulmonic diastolic murmurs, tricuspid or mitral flow diastolic murmurs or continuous murmurs * any chest wall configuration preventing adequate contact between the cardiosond acoustic recording sensor and precordium * any medical condition that would be expected to affect ct angiography image quality

Keywords: coronary artery disease
myeloid derived suppressor cells control by signal regulatory protein-alpha: investigation in hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: project is to study and develop anti-signal regulatory protein α (sirpα) antibodies (ab) as a new immunotherapy strategy in cancer. samples harvested from hepatocellular carcinoma (hcc) and ovarian cancer patients will be used in evaluation of the sirp-cd47 expression and of the effect of the anti-human signal regulatory protein (hsirp) ab on various cellular types from patients and healthy volunteers.


Eligibility criteria:
inclusion criteria: * adult * hcc patients (all bclc stages accepted) * patient consent for the use of their biological samples exclusion criteria: * patient with other cancers * hepatitis c or b positive * hcc treatment by chemo-embolization under 3 months * under sorafenib treatment within the month prior to collection * underage or under guardianship patients

Keywords: biobank analyses effect evaluation of the drug patient-derived cells sirpα/cd47 expression
comparative study of azasite plus compared to azasite alone and dexamethasone alone to treat subjects with blepharoconjunctivitis

Conditions: Blepharoconjunctivitis

Summary: the purpose of this study is to determine if azasite plus is effective and safe for the treatment of blepharoconjunctivitis compared to azasite alone and dexamethasone alone.


Eligibility criteria:
inclusion criteria: * have a clinical diagnosis of blepharoconjunctivitis * must be willing to discontinue contact lens wear for the duration of the study * additional inclusion criteria also apply. exclusion criteria: * have known sensitivity or poor tolerance to any component of the study medications. * have any clinically significant cardiovascular disorders * have any history of liver or kidney disease resulting in persisting dysfunction * have prior (within 30 days of beginning study treatment) or anticipated concurrent use of an investigational drug or device. * additional exclusion criteria also apply.

Keywords: blepharoconjunctivitis, ophthalmology
design and evaluation of a novel methodology for sabr for lung cancer

Conditions: Lung Cancer

Summary: aims: to increase the number of patients that benefit from stereotactic ablative radiotherapy (sabr) for lung cancer using new treatment methods that reduce the amount of non-cancer tissue receiving a high radiation dose without affecting tumour dose coverage. background: sabr is a treatment for lung cancer which offers major advantages over conventional radiotherapy. it is a more precise highly effective treatment with significantly improved treatment outcomes (greater elimination of cancer cells). sabr requires high doses per treatment so extreme accuracy is required to minimise healthy tissue damage. normal breathing results in significant tumour movement, therefore to avoid missing the tumour, larger volumes need to be treated, resulting in more good tissue damage. uk standard practice requires the tumour to be irradiated in all positions during breathing whilst the new approach targets the tumours at the position it spends most time to minimise normal tissue affected by radiation. current practice for sabr patients would be improved (fewer severe radiation side-effects) and potentially could become a viable treatment for high risk patients. methods: 30 sabr patients receiving current standard sabr treatment will be recruited. this is an observation study in which patients will continue to receive standard of care but in addition: * a camera will be used to make videos of how the patient's chest moves in 3d at ct and treatment. i will build a complex mathematical model that infers movement of the tumour from movement of the chest. * their breathing patterns, corresponding tumour motions and treatments plans will be utilised to develop a method for safely implementing the new treatment approach.


Eligibility criteria:
inclusion criteria: all patients eligible for and who have consented to receive lung sabr at the royal surrey county hospital will be eligible for entry into this study. • over 18 years old (radiotherapy is not delivered to 16-18yr olds at rsft). no upper age limit. exclusion criteria: patients with irregular breathing motion resulting in failed 4dct * patients with unusual chest surface deformities * patients who lack the capacity to consent * patients unable to read and communicate in english

Keywords: radiotherapy sabr
effect of increasing doses of tiopronin on cystine capacity in patients with cystinuria

Conditions: Cystinuria

Summary: the purpose of this study is to determine the minimum effective dose of the cysteine binding thiol drug (cbtd) tiopronin on urine cystine capacity, which is a measure of cystine solubility in the urine, in patients with cystinuria to evaluate the effect of escalating doses of cystine binding thiol drugs on the cystine capacity of the urine. the overall goal will be to help guide therapy and ultimately minimize unnecessary side effects caused by larger dosages. cystinuria is a rare genetic disease that can lead to significant morbidity in affected patients due to the recurrent nature of the disease. this study will follow the levels of urine cystine capacity in order to help guide treatment and to use lower than usually prescribed tiopronin doses to decrease the potential side effects while maintaining therapeutic benefit. this will increase adherence with the medications by decreasing the burden of the large number of pills that need to be taken daily.


Eligibility criteria:
inclusion criteria: * patients with a confirmed laboratory diagnosis of cystinuria who meet the following criteria: (1) stone analysis demonstrating cystine as a component, or (2) increased urinary cystine excretion (\>250mg/24hrs in adults). * a medical regimen that includes tiopronin. * willing to use a medically accepted form of birth control, if female and of child bearing- potential * ability to reliably urinate in a collection vessel and measure urine volume. * ability to give informed consent. * documentation of a stable complete blood count (cbc) and urinalysis (ua) in the six month period prior to the date of enrollment. * enrollment in rare kidney stone consortium (rksc) protocol 6401 (cystinuria registry) exclusion criteria: * women who are pregnant, breastfeeding, or trying to become pregnant * patients with renal colic * patients who are scheduled to undergo a surgical procedure * inability to give informed consent
"which type of exercise is more effective in chronic constipation?

Conditions: Chronic Constipation

Summary: in this study, it will be investigated whether a daily 30-minute walk or abdominal breathing exercise is more effective on chronic constipation.

according to the results of population-based studies conducted in our country, the frequency of constipation varies between 22-40%. in addition to medical treatment, alternative treatments are frequently used in the treatment of constipation. one of these is exercise. in addition to medical treatment, alternative treatments are frequently used in the treatment of constipation. one of these is exercise. many traditional breathing techniques developed in asia are thought to be beneficial to health. in the light of this information, it is aimed to monitor actigraph gt3x+ accelerometer, which is an objective measurement method of physical activity, and to evaluate the effectiveness of breathing exercise, which is one of the abdominal breathing exercises.

Eligibility criteria:
inclusion criteria: * able to speak and understand turkish, * voluntarily accepted to participate in the research and written consent form was obtained (those who could fill out the forms themselves using their hands, and those who could not use it, from their relatives with verbal consent), * at least 18 years of age and over, * oriented to place, person and time, * patients who do not have spinal cord injury, parapilegia, or quadriplegia that may physiologically impede the individual's intestinal excretion does not have any problems that prevent cognitive, sensory and verbal communication, * patients who are conscious and not using any sedating medication * men and women aged 20-80 at the time of approval exclusion criteria: * pregnancy or possible pregnancy; * the habit of doing all kinds of breathing exercises;
cost effectiveness of language services in hospital emergency departments (eds)

Conditions: Language Discordance

Summary: numerous studies suggest that the use of in-person, professionally trained medical interpreters can reduce health care costs associated with diagnosing and treating patients with limited english proficiency. however, few studies have specifically addressed the question of the cost-effectiveness of language services in health care settings. this study used a randomized controlled study design to compare the cost-effectiveness of using professional interpreters with spanish-speaking patients seen in hospital emergency departments (eds) versus using the usual language services available to these patients. the main goal of the study was to estimate the effect that professional interpreters have on resource utilization and patient/provider satisfaction in the ed compared to the language services usually offered in these settings. our hypothesis was that use of trained interpreters would lead to more cost-effective provision of ed services.


Eligibility criteria:
inclusion criteria: * limited english proficient (lep) spanish-speaking patients * adults aged 18 or older * lep parents of children seen in emergency departments exclusion criteria: * cognitively impaired, comatose, or traumatized patients * healthy volunteers * prisoners * hospital employees

Keywords: limited english proficiency cost-effectiveness emergency departments language discordance satisfaction limited english proficient patients spanish-speaking patients
etiologies, definitive diagnosis and patient outcomes in altered level of consciousness in the emergency department

Conditions: Consciousness Disorders

Summary: when someone starts acting differently in terms of how alert or awake they are, it can be a tough situation for emergency (er) department doctors.e exact and definitive etiologies of aloc that can be intracranial or extracranial.

the change in terms of mental state in accordance with how alert and awake patient is termed as altered level of consciousness. etiologies will be classified by using convenience sampling. gcs\<14 patients will be included in this study. data will be collected through a slight modification in a pre-designed performa. reference point for the data collection will be the time of discharge from the emergency department. in previous studies mostly, etiologies were classified as extracranial and intracranial. some studies found neurological etiologies most dominant as an extra cranial and some studies found systematic infections ,metabolic causes and some demonstrated that intracranial etiologies were dominant. so, in this study we will find the definitive diagnosis in patient having aloc which can be intracranial or extracranial. and also, it will be compared with gcs scale. this study will identify th

Eligibility criteria:
inclusion criteria: * patients with gcs\<15, age group 18 years to 90 years which come in emergency department due to any etiology will be included in this study. exclusion criteria: * gcs = 15 will be excluded from the study. * patients coming in any outpatient department setting or other than emergency department and age group \ 90 will be excluded from this study.
establishing a tumor bank in families with multiple lymphoproliferative malignancies

Conditions: Non-Hodgkin's Lymphoma; Hodgkin's Disease; Leukemia, Lymphocytic, Chronic; Lymphoproliferative Disorders

Summary: the purpose of this study is to investigate possible genetic factors that contribute to the development of lymphomas. the databank will be used to determine whether familial lymphomas have unique genetic characteristics different from sporadic lymphomas and to attempt to identify a gene that confers an increased risk of lymphoma.

* patients who participate will be asked to complete detailed family and medical history questionnaires initially, with a follow-up questionnaire every year. * patients will be asked to supply a blood sample and possibly a mouthwash sample, both of which can be done by mail. * patients will be asked to consent to the release of their lymphoma tissue block for the purposes of the study. * patients will be given letters of invitation for their affected relatives to invite them to participate.

Eligibility criteria:
inclusion criteria: * any individual diagnosed with non-hodgkin's lymphoma or hodgkin's disease or chronic lymphocytic leukemia (cll), who has a 1st degree relative (parent, sibling or child) with a lymphoproliferative disorder; or families in which the individual has a lymphoproliferative disorder, and an unusual clustering of frequent or premature solid tumors is also observed. * family members of the individual, either affected or unaffected with lymphoma, who are contacted by the individual and agree to participate in the study. * deceased family members may be included in the study. public records such as death certificates may be used to confirm the history. consent for medical records or tissue blocks will be obtained from the deceased family member's next of kin. the hierarchy of relatives defined as next of kin is spouse, offspring, parents and siblings. archived tissue samples may be used for genetic research. * age \> 18 years exclusion criteria: * subjects without a family history of lymphoma

Keywords: non-hodgkin's lymphoma hodgkin's disease chronic lymphocytic leukemia lymphoproliferative disorder genetics
outpatient vasodilator assessment using iloprost in pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: this study will compare the clinical efficacy of inhaled iloprost as an invasive, selective vasodilator in the cardiac catheterization laboratory in patients with pulmonary hypertension to the gold standard of inhaled nitric oxide. it will also examine whether echocardiographic estimates of response to inhaled iloprost can predict responsiveness to invasive vasodilator testing in patients with pulmonary hypertension.

iloprost was the first inhaled prostacyclin analogue to be fda-approved for the treatment of pulmonary arterial hypertension. iloprost aerosol has been shown to significantly improve pulmonary hemodynamics in patients with idiopathic pulmonary hypertension (ph), with an effect greater than nitric oxide and sildenafil. it has also been shown to be more effective than nitric oxide at reducing pulmonary arterial pressure (pap) than prostacyclin infusion when used in the cardiac catheterization laboratory. because of its administration through inhalational means, iloprost has the advantage of selective action on the pulmonary vasculature with avoidance of the systemic side effects that plague many of the other treatments for ph. the investigators intend to compare the efficacy of inhaled iloprost in reducing pulmonary artery pressure to the gold standard of nitric oxide in patients with pulmonary hypertension. without an established noninvasive algorithm to identify beneficial hemodynamic response to vasodilators, patients with pulmonary hypertension (ph) are routinely subjected to expensive and invasive testing. echocardiography is routinely used to facilitate a diagnosis of ph and a few echocardiographically-derived estimates have even been shown to correlate with vasodilator responsiveness and survival. dynamic, real time changes in echocardiographic parameters have not been previously evaluated as a predictor of vasodilator responsiveness or of clinical outcome. the investigators will examine whether echocardiographic changes in response to inhaled iloprost can predict invasively derived vasodilator responsiveness and help assess prognosis in patients with pulmonary hypertension, possibly even obviating the need for invasive testing.

Eligibility criteria:
inclusion criteria: * adult patients no younger than 18 years of age * recently diagnosed pulmonary hypertension (defined by rv systolic pressure of ≥ 40 mmhg as measured by echocardiography), going for invasive hemodynamic assessment for pulmonary hypertension * normal left ventricular function defined as a left ventricular ejection fraction (lvef) greater than or equal to 50% exclusion criteria: * heart failure (lvef \ stage 1, history or symptoms of left heart failure) - group ii pulmonary hypertension * 2+ or higher mr or ai * inadequate echocardiographic windows * pregnancy * systolic blood pressure ≤ 90 mmhg

Keywords: pulmonary hypertension vasodilator challenge echocardiography outcomes iloprost inhaled nitric oxide
the effect of intravenous fentanyl prior the end of surgery on emergence agitation in paediatric patients after general anesthesia

Conditions: Agitation

Summary: the propose of this study is to determine the effect of intravenous fentanyl prior the end of surgery on the incidence and severity of ea in pediatric patient.

emergence agitation (ea) is a common self limiting problem after emerging from general anesthesia (ga) especially in pediatric patients. the incidence of ea in thai population, the incidences of ea 43.2% in pediatric patients aged between 2-9 years. there have been many studies tried to reduce the incidence of ea in various ways such as preoperative anxiety reduction method and medication. premedication, sedative drugs and narcotic drugs were used to reduce the incidence of ea.

Eligibility criteria:
inclusion criteria: * aged between 2-9 years * ipd patient * receiving chloral hydrate 50mg/kg (bw\ 20 kgs)per oral for premedication * scheduled for one kind of these surgeries; otolaryngology, ophthalmology, urology, orthopedic,general surgery, plastic surgery and cardiac catheterization. exclusion criteria: * asa physical status iv-v * history of drug allergy:thiopental, fentanyl cisatracurium, chloral hydrate and diazepam

Keywords: emergence agitation pediatric patient fentanyl incidence of emergence agitation severity of emergence agitation adverse outcome from intervention