Kornimate/medical-research-clean huggingface dataset:
intervening for increased quality of life among older people in sweden

Conditions: Physical Inactivity; Mental Health Issue

Summary: in the wake of the covid-19 pandemic, sweden and other countries have become aware of how life has changed; the world is now a "hybrid world" where many daily activities have moved online. the forced physical isolation has also led to an increase in depression and loneliness, especially among elderly people. traditional interventions often involve physical contact, and there are valuable lessons to be learned from this situation, where physical isolation is forced, in order to mitigate the consequences both during and after this pandemic. the overall purpose of this project is to study physical activity as a way to engage in and maintain an active lifestyle and /or increase the quality of life and limit mental health problems for older people and to study how scalability, accessibility, commitment, and adherence can be improved with flexible programs with digital tools. the specific research question is: is there a difference between the online exercise program and the onsite exercise program in terms of physical activity, balance, motivation, quality of life and mental health? the results are expected to give insights into how to increase physical activity using flexible programs with digital options and to maintain quality of life among the elderly. by giving the elderly population different options for being physically active and thereby empowering this group, this project contributes to creating a socially sustainable community in which elderly citizens are included.


Eligibility criteria:
inclusion criteria: * understand swedish exclusion criteria: -
the impact of continuous transcutaneous co2 (tcco2) monitoring in extremely low birth weight (elbw) infants

Conditions: ELBW - Extremely Low Birth Weight Infant; IVH- Intraventricular Hemorrhage

Summary: an observational study comparing outcomes of extremely low birth weight (elbw) infants that were monitored with non-invasive transcutaneous co2 (tcco2) monitor to infants that were not monitored by tcco2 monitor.


Eligibility criteria:
inclusion criteria: * elbw infants need of respiratory support exclusion criteria: * parental refusal ivh before study entry chromosomal abnormalities congenital central nervous system (cns) abnormalities
a study of metmab administered to patients with advanced non-small cell lung cancer, in combination with tarceva (erlotinib)

Conditions: Non-Small Cell Lung Cancer

Summary: this is a phase ii, double-blind, randomized, multicenter trial designed to preliminarily evaluate the activity and safety of treatment with metmab + erlotinib versus erlotinib + placebo in second- and third-line non-small cell lung cancer (nsclc). up to 180 patients will be randomized in a 1:1 ratio to one of the two treatment arms.


Eligibility criteria:
inclusion criteria: patients must meet the following criteria for study entry: * histologically confirmed nsclc * availability of a tumor specimen * recurrent or progressive disease following at least one chemo containing regimen for stage iiib/iv disease * measurable disease in accordance with response evaluation criteria in solid tumors (recist) * at least one measurable lesion on a pre-treatment 18-fluorodeoxyglcose-positron emission tomography (fdg-pet) scan that is also a target lesion on computed tomography (ct) according to recist exclusion criteria: * more than two prior treatments for stage iiib/iv * more than 30 days of exposure to an investigational or marketed agent that can act by egfr inhibition, or a known epidermal growth factor receptor (egfr)-related toxicity resulting in dose modifications * chemotherapy, biologic therapy, radiotherapy or investigational drug within 28 days prior to randomization * untreated and/or active (progressing or requiring anticonvulsants or corticosteroids for symptomatic control) central nervous system (cns) metastasis * history of serious systemic disease within the past 6 months prior to randomization * uncontrolled diabetes * major surgical procedure or significant traumatic injury within 28 days prior to randomization * anticipation of need for a major surgical procedure during the course of the study * local palliative radiotherapy within 7 days prior to randomization or persistent adverse effects from radiotherapy that have not been resolved to grade ii or less prior to randomization * symptomatic hypercalcemia requiring continued use of bisphosphonate therapy

Keywords: tarceva lung cancer nsclc
functional status for surgically and non-surgically treated patients with acute achilles tendon rupture following a public municipal rehabilitation

Conditions: Achilles Tendon Rupture

Summary: a total achilles tendon rupture is a common injury most often occuring in people aged between 30 and 50 years. the injury is more common amongst men than women (ratio 3:1) and typically occur during sports activities involving excentric and/or plyometric muscle work in plantar flexion of the foot (e.g., jumping, sprinting, change of directions). overall, there is no significant difference in treatment outcomes between surgical and non-surgical treatment besides a slightly greater risk of adverse events in surgical treatment and a small increased risk of re-rupture in non-surgical treatment. several studies have investigated the importance of rehabilitation protocols without outcome differences between groups comparing more or less aggressive strategies. achilles tendon rupture often leads to significant limitations in functional level. some of the most common used outcome measures for functional status are the heel rise tests evaluating endurance and maximum heel rise height. studies using these tests often shows substantial deficits several years after the injury. the purpose of this study is to investigate factors associated with functional status after rehabilitation.


Eligibility criteria:
inclusion criteria: * patient has an acute achilles tendon rupture (treated within 14 days after injury). * adult patients aged of 18 years or older. * patients has given informed consent to participate in the study. exclusion criteria: * patients with bilateral achilles tendon rupture * patients with re-rupture of previous achilles tendon rupture

Keywords: achilles tendon rupture cohort study functional status heel rise tests associating factors public municipal rehabilitation
descriptive study of emergency room visits from nursing home residents for behavioral problems at the nancy university hospital: place of the advanced practice nurse

Conditions: Behavioral Disorders

Summary: the demographic evolution of old age is a reality. after the age of 75, 2 out of 3 people living in institutions have neurocognitive disorders. behavioural disorders such as physical aggression, agitation, hallucinations, sleep disorders, generate difficulties in the management of these patients and lead to unscheduled emergency hospitalizations. non-pharmacological management of behavioral disorders is recommended as a first-line treatment because of its low risk and potential improvement (haute autorité de santé 2009). however, this management is not simple and obvious to put in place, especially since not all elderly people with behavioural disorders are in adapted structures. the advanced practice nurse specializing in geriatrics has a place in this care pathway. because of her skills, she could "organize multi-professional care, set up analyses of practices within the nursing homes, train caregivers appropriately, and limit hospitalizations due to behavioral problems" (saliege l. 2020). advanced practice nursing is in its infancy in france, and everything remains to be done (international council of nurses- directive). the aim of the study is to identify the number of emergency room visits by people aged 75 and over for behavioral problems in nursing home during a 6 month-period.


Eligibility criteria:
inclusion criteria: * person who has received full information on the organization of the research and has not objected to the use of this data * elderly men and women 75 years of age and older at the time of the emergency room visit * having for main residence one of the nursing homes of the grand nancy * administratively present in the emergency department * having been admitted to the emergency room for the following reasons: * behavioural problems * agitation * dementia * disorientation * delirium exclusion criteria: * people under 75 years of age * residing at home or in a senior residence or in a nursing home outside grand nancy * referred by an inpatient department (rehabilitation department) * other reasons for emergency room use such as "depression" and "apathy
compensatory mechanisms in parkinson disease (pd)

Conditions: Parkinson's Disease

Summary: parkinson's disease is characterized by a large number of non motor, especially neuropsychiatric, signs. their pathophysiology is complex but the role of dopaminergic and serotoninergic systems dysfunction is suggested by several studies. in addition, the serotoninergic system is involved in the pathophysiology of dyskinesias. very few studies have analyzed the abnormalities of these two neurotransmission systems at disease onset, in de novo pd patients. furthermore, the parallel evolution of the degeneration of the dopaminergic and serotoninergic systems with disease progression remains unknown. thus the present study aims at determining, by using pet and 11c-pe2i and 11c-dasb the respective role of the serotoninergic and dopaminergic systems dysfunction in motor and non motor manifestations in pd, at different evolution stages.


Eligibility criteria:
inclusion criteria: patients * patients presenting doparesponsive parkinson's disease * patient's age between 40 and 70 years old * absence of other neurological or psychiatric disease * absence of cognitive decline ( mattis \> 130) * for women of childbearing age a pregnancy test and a contraceptive method will be required * informed consent sign healthy subjects * subject's age between 40 and 70 years old * absence of neurological or psychiatric disease * absence of cognitive decline ( mattis \> 130) * for women of childbearing age a pregnancy test and a contraceptive method will be required * informed consent sign exclusion criteria: patients * patient's age \ 70 years old * other neurological or psychiatric disease * cognitive decline (mattis \< 130). * having participated to a pet or spect study in the last 12 months * pregnancy * severe concomitant disease healthy subjects * subject's age \ 70 years old * neurological or psychiatric disease * cognitive decline (mattis \< 130). * having participated to a pet or spect study in the last 12 months * pregnancy * severe concomitant disease

Keywords: parkinson serotonin dopamine non motor progression pet
atg in hla-matched sibling hsct as gvhd prophylaxis

Conditions: Hematopoietic Stem Cell Transplantation

Summary: the protocols including ciclosporin a （csa）+methotrexate (mtx) +mycophenolate mofetil(mmf) have been widely used for graft-versus-host disease (gvhd) prophylaxis in allogeneic hematopoietic stem cell transplantation from hla-matched sibling donor (msd). nevertheless, severe chronic graft-versus-host disease (cgvhd) remains an obstacle for msd hsct. a growing body of studies have suggested antithymocyte globulin (atg) could reduce the incidence of cgvhd. this study is aim to evaluate the efficacy of a protocol that includes csa, mtx, mmf and atg in recipients of msd hsct.


Eligibility criteria:
inclusion criteria: 1. a patient age of 18-65 years 2. msd transplant recipient 3. subjects (or their legally acceptable representatives) must have signed an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study exclusion criteria: 1. any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure) 2. patients with any conditions not suitable for the trial (investigators' decision)

Keywords: hematopoietic stem cell transplantation antithymocyte globulin graft-versus-host disease
the effect of bilateral rectus sheath block versus wound infiltration in gynecooncological patients

Conditions: Postoperative Pain

Summary: postoperative pain is a serious problem in gynecological oncology patients who underwent median vertical incision. the aim of our study is to compare ultrasound guided bilateral rectus sheath block and local anesthetic wound infiltration application in postoperative pain control.

this single-center prospective,observational study was approved by institutional ethics committee (decision number: 2023/514/257/31, date: 29/05/2023) and was performed in accordance with the declaration of helsinki.. between june and september 2023, ultrasound guided bilateral rectus sheath block or local anesthesia administered to the patients in the gynecological oncology operating room of the university of health sciences kartal dr lutfi kırdar city hospital at the end of the surgery. in the postoperative period, the pain level of the patients was recorded with the numerical rating scale at 2, 6, 12 and 24 hours by an anesthesiologist who was unaware of the application. the data were entered into the table by an anesthesiologist who did not know which application was performed. thus, data were recorded using a randomized triple blinding method in which the patient, the researcher, and the recording staff were blinded. all patients underwent preoperative evaluation one day before surgery and written informed consent was obtained for participation for the study. the procedure to be performed on the patients was planned in accordance with the randomization made by the statistician. the anesthesiologist who would perform the intervention participated in the study blindly to the drugs and groups. patients in group i underwent postoperative ultrasound-guided bilateral rectus sheath block at the t9-10 level with 20 ml of 0.25% bupivacaine (40 ml in total). for the patients in group ii (control group), 20 ml of 0.25% bupivacaine was applied subcutaneously to each wound lip (40 ml in total). at the end of the surgery, 100 mg tramadol iv and paracetamol 1mg/kg iv were administered to both groups as analgesics. pain, ranging from 0 (no pain) to 10 (worst imaginable), was queried by another anesthesiologist who was blind to the procedure. 2\*1 non-steroidal anti-inflammatory was routinely administered as an analgesic in the ward, but the first application time was planned by questioning the patient's pain. rescue analgesia with tramadol was administered if the patient ranged the pain \>4 . pain was measured at the 2nd, 6th, 12th and 24th hours postoperatively, and tramadol consumption was recorded.

Eligibility criteria:
inclusion criteria: * electively gynecooncological surgery patients with median incision * asa ii-iii, * between 18-65 years exclusion criteria: * asa iv and above * over 65 - under 18 years of age * previous laparotomy * allergy to local anesthetics

Keywords: postoperative pain
the effect of cataract on photoentrainment of the circadian rhythm in humans

Conditions: Cataract

Summary: cataract is globally the most common cause of blindness and in denmark the operation with - 50.000 treatments per year - is the most common eye operation. the cause of cataract is growth and denaturation of the lens proteins. this leads to an increased absorption of blue light and increased light scatter. this may affect newly discovered cells in the retina that are involved in the regulation of the circadian rhythm. when the internal circadian rhythm is not synchronized with the external day and night a phase-shift occurs. most people know of this discomfort as jet-lag, but the consequences may be much more severe such as heighten risk of cancer and cardiovascular disease. the goal of this project is to study how the circadian regulating cells of the retina is affected by cataract and by the operation. cataract patients are studied before and after the operation with questionnaires, hormone and activity measurements and with a specialized pupil measurement that measures the indirect response of the circadian regulating cells to blue light. results from this study aim to shed light on the regulatory mechanisms of the eye on the circadian rhythm and how these are affected by cataract. furthermore, choice of intraocular lens is evaluated. this may have impact on clinical practise especially with regard to choice of intraocular lens and widened indications for cataract surgery.


Eligibility criteria:
inclusion criteria: * age related/senile bilateral cataract * eligible for phaco-emulsification on both eyes exclusion criteria: * known eye disease other than cataract. * known systemic disease, which may affect the retina (untreated hypertension, dm etc.) * known systemic disease, which may affect the lens. * known psychiatric disease. * known sleep or circadian rhythm disorder, not caused by lowered blue light transmission by the lens. * per- and post operative complications * use of drugs that may affect the sleep. for a subpopulation also: * poor cooperation. * severe refraction abnormalities. * previous eye surgery * nystagmus * congenital or acquired abnormalities of: eye lids and eye area, cornea or iris. * use of medicine that may affect the pupillary response. * use of drugs that may affect the pupillary response.

Keywords: cataract circadian rhythm pupillometry blue light transmission questionnaire sleep
impact of umbilical cord cleansing with 4.0% chlorhexidine on neonatal mortality

Conditions: Omphalitis; Infection

Summary: a community based trial that seeks to address the effect of umbilical cord cleansing using 4.0% chlorhexidine cleansing solution

of the annual four million neonatal deaths, 99% occur in developing countries, and more than one-third globally can be attributed to infections. in areas with high-mortality rates, the proportion attributable to infections is as high as 50%. many infections in infants can be prevented or treated with already existing measures, yet finding the best way to provide these measures in communities that are limited in resources need to be identified. applying chlorhexidine to the umbilical cord of newborns may be a simple way to help reduce neonatal mortality and morbidity in the community at low cost. a study by our group was recently completed in nepal. it was a large community-based, factorial-designed trial in southern nepal to: (1) assess the impact of newborn total body skin cleansing with 0.25% chlorhexidine on neonatal mortality and morbidity and (2) assess the impact of cleansing of the umbilical stump with 4% chlorhexidine on omphalitis and neonatal mortality. the results of these studies have suggested that chlorhexidine antisepsis interventions may significantly reduce neonatal mortality and omphalitis. a single full body cleansing of the neonate with chlorhexidine as soon as possible after birth reduced mortality among low birth weight (lbw) infants by 28%. repeated cleansing of the umbilical stump with chlorhexidine reduced the rate of severe cord infection by 75% and, if this treatment was begun within the first 24 hours following birth, reduced neonatal mortality by 34%. in rural bangladesh, over 90% of women deliver at home with only untrained local women or family members in attendance, and low birth weight babies are delivered approximately 30% of the time. the overall neonatal mortality rate exceeds 36 per 1000 live births and in order to reduce this burden, simple, cost-effective interventions that can be delivered at the community level are urgently needed. given the potential impact of repeated chlorhexidine cleansing of the cord demonstrated in the nepal trial, a replication study of this regimen and further investigations of more simple regimens are necessary. the number of treatments necessary to reduce neonatal mortality has important programmatic implications for who can deliver the intervention, and how it is packaged.

Eligibility criteria:
inclusion criteria: * live-born infants delivered in one of three upazillas of sylhet district (zakiganj, khanaighat, beanibazar) * married women of reproductive age within their individual target areas listed above exclusion criteria: * individuals outside of the target area in sylhet(zakiganj, khanaighat, beanibazar) * infants not met at home by a project worker during the first seven days of life

Keywords: omphalitis neonates umbilical cord infection infant mortality neonate morbidity chlorhexidine
promoting lung cancer screening awareness and implementation in hispanics/latinx head and neck cancer survivors

Conditions: Head and Neck Cancer

Summary: the purpose of this study is to assess the awareness of eligibility of lung cancer screening in hispanic/latinx head and neck cancer (hnc) survivors using a survey questionnaire; and to understand the barriers to screening using qualitative interviews.


Eligibility criteria:
inclusion criteria: * participants must be able to understand, and sign informed consent form. * age ≥ 18 years. * participants must self-identify as hispanic/latinx. * individuals must be head and neck cancer survivors (treated locally with surgery, radiation alone, or definitive chemoradiation ≥ 5 years earlier and have no signs/symptoms to suggest recurrence of disease). * subjects that meet lung cancer (lc) screening eligibility according to united states preventive services task force (uspstf21) and/or national comprehensive cancer network (nccn). for patients with a history of head and neck cancers, the nccn recommends annual screening with low dose computerized tomography (ldct) in those who have had a history of 20 pack years of smoking or more. uspstf21 lc screening eligibility includes adults ages 50-80 that are current smoker or former smokers that quit within 15 years and have a 20 pack-year history or more of smoking. exclusion criteria: * individuals with pre-established diagnosis of lung cancer. * participants with current diagnosis of any active malignancy. * subjects that had undergone lung imaging within previous 3 years. * pregnant or nursing mothers. * individuals that received head and neck related treatment less than 5 years before screening. * individuals with \< 20 pack year history of smoking. * subjects with previous history of distant metastatic head and neck cancer.