Kornimate/medical-research-clean huggingface dataset:
comparison between bare scleral technique and conjunctival auto-graft on corneal topography after pterygium surgery

Conditions: Corneal Topography

Summary: aim of the work: to study the corneal topographic pattern changes in patients who have pterygium excision by two surgical techniques (bare sclera, conjunctival autograft).

pterygium is one of the common ocular surface disorders , it's is an elastotic triangular fibro-vascular tissue covered by conjunctival epithelium that spreads over the cornea. pterygium causes differences in curvature \& power across the cornea . the prevalence of pterygium varies from 1.1% to 53% globally in different environmental conditions. risk factors include;uv radiation, geographical latitude near to the equator, outdoor activity , aging, male, and dusty environment. pterygium excision is important in patients suffering from blurred vision due to astigmatism . surgical techniques include ; bare sclera excision, conjunctival autograft, conjunctival transpositional flap, and amniotic membrane grafting. pterygium excision increases in the mean central corneal curvature \& reduces astigmatism that leads to improvement in visual acuity. corneal topography is a gold standard in corneal pathology follow-up. corneal topography is a computer assisted diagnostic tool that creates a three-dimensional map of the surface curvature of the cornea. corneal topography produces a detailed, visual description of the shape and power of the cornea. in this study , corneal topography is used to detect how does corneal curvature change after excision of pterygium .

Eligibility criteria:
inclusion criteria:- * patients with pterygium not associated with other pathologies (suitable for excision). * nasal pterygium extended to the cornea. exclusion criteria: - * associated pathologies such as glaucoma, and cataract. * corneal opacities or irregularities, scars, dystrophy or ectasia. * patients who underwent previous corneal surgery (including refractive surgery) * pseudo-pterygium.

Keywords: pterygium surgery by bare scleral & autograft
time need to detect mobile phone use to prevent muscle fatigue

Conditions: Mobile Phone Use

Summary: using a smart phone while adopting a poor posture can cause various physical problems. the neck and shoulders are particularly vulnerable to pain due to smart phone use, with the muscles showing a high level of muscle fatigue, resulting in exhaustion and pain, therefore, determining the durable time to use the smart phone will protect us from abnormal posture and protect our muscle and ligaments. furthermore avoid the incorrect position of use smartphone position.

-purpose of the study: to investigate the electrical muscle activity during used mobile phone -back ground : using a smart phone while adopting a poor posture can cause various physical problems. the neck and shoulders are particularly vulnerable to pain due to smart phone use, with the muscles showing a high level of muscle fatigue, resulting in exhaustion and pain, therefore, determining the durable time to use the smart phone will protect us from abnormal posture and protect our muscle and ligaments. furthermore avoid the incorrect position of use smartphone position. -hypotheses: there are no statistical significant relation between time of used smart phone and muscle fatigue. -subjects: one hundred fifty healthy children of both genders will participate in this study. * inclusion criteria: 1. their ages ranges from 12-14 years. 2. subjects of school age childhood. 3. not rolled on any regular athletic activity. 4. children should be at the same socioeconomic level. * exclusion criteria: 1. individual with neck pain 2. any upper limb and spinal deviation. 3. worker children. * instrumentation: •surface electromyography (emg) * design of the study: all subjects shouldn't use the phone for an hour before the measurement each child setting in a chair with their feet on the floor and the elbow slight flexion, holding a smartphone in favorite position of used smart phone.

Eligibility criteria:
inclusion criteria: 1. their ages ranges from 12-14 years. 2. subjects of school age childhood. 3. not rolled on any regular athletic activity. 4. children should be at the same socioeconomic level exclusion criteria: 1. individual with neck pain 2. any upper limb and spinal deviation. 3. worker children.
the medacta international sms post-marketing surveillance study

Conditions: Arthrosis; Traumatic Arthritis; Rheumatoid Polyarthritis; Congenital Hip Dysplasia; Avascular Necrosis of the Femoral Head

Summary: this is a post-marketing surveillance of sms femoral stem prosthesis.


Eligibility criteria:
inclusion criteria: * individuals with a severely painful and/or disabling hip joint with osteoarthritis, traumatic arthritis or developmental dysplasia of the hip or avascular necrosis of the femoral head. * in order to take part in this study, all study participants must be between the ages of 18 and 75 years of age, at the time of surgery. * scheduled for a primary total hip replacement. exclusion criteria: * active infection * pregnancy * mental illness where the known condition is likely to compromise the patient's ability to consent, affect the patient's assessment of their progress or complete the 10 year cycle of follow-up appointments and reviews * grossly distorted anatomy (surgeon's discretion) * osteomalacia where uncemented implant fixation is contraindicated * active rheumatoid arthritis. * osteoporosis * metabolic disorders which may impair bone formation where uncemented implant fixation is contraindicated * muscular atrophy or neuromuscular disease * allergy to implant material * any patient who cannot or will not provide informed consent for participation in the study * those whose prospects for a recovery to independent mobility would be compromised by known coexistent, medical problems
separate and combined extrapancreatic effects of gip and glp-1

Conditions: Pancreatectomy; Hyperglycemia

Summary: the two gut-derived hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1 (glp-1) are secreted from intestinal cells in relation to a meal and increase insulin secretion from the pancreas. the hormones also exert effects outside the pancreas, but especially for gip, these are poorly investigated. because of this, only glp-1 based drugs (glp-1 receptor agonists) are on the market for the treatment of type 2 diabetes and obesity. nonetheless, a new drug is in clinical development: a combined gip-glp-1-receptor agonist (tirzepatide), which has shown better results than glp-1 alone. the mechanism behind these impressive effects are unknown and in this study, the investigators will look into the exptrapancreatic effects of gip and glp-1, separate and combined and thus elucidate the mechanisms of action of this new drug class.


Eligibility criteria:
inclusion criteria: * total pancreatectomy * caucasians between 30-75 years of age * blood haemoglobin \>7.0 mmol/l for males and \>6.5 mmol/l for females exclusion criteria: * pancreatectomy within the last 3 months * ongoing chemotherapy or chemotherapy within the last 3 months * treatment with glp-1 receptor agonists within the last 3 months * renal impairment (estimated by estimated glomerular filtration rate (egfr) \<60 ml/min/1.73 m2) and/or albuminuria * calcium related disease, hypo-/hyperthyroidism * known significant liver disease, plasma alanine aminotransferase (alt) or aspartate aminotransferase (ast) ≥3 × normal value or inr (the international normalised ratio based on prothrombin time) outside the normal range * severe arteriosclerotic heart disease or heart failure (new york heart association (nyha) group iii or iv) * pregnancy and/or breastfeeding * use of more than 14 units of alcohol per week or abuse of narcotics * any condition that the investigator feels would interfere with trial participation
treatment of post-covid syndrome in patients treated in intensive care

Conditions: COVID-19; Mental Health Disorder

Summary: the present study is a pilot randomized controlled trial, which identifies and diagnoses mental health problems in survivors of critical covid-19 infection at 12 months post-icu care, and randomize patients to either an act-enforced cbt intervention, or to treatment as usual.

this is a pilot rct aiming to intervene in symptoms of poor mental health in covid survivors at 12 months after icu care for the covid infection. based on the uncertain number of patents who screen positive for mental health problems 12 months after icu care, based on the novelty of the condition assessed, and the uncertainty about which treatment effects to expect on mental health outcomes, the study was designed as a pilot study, with feasibility measures (consent, adherence and satisfaction with the treatment) as the primary variables, and with effects on mental health symptoms as secondary variables. the study plans to assess and randomize a convenience sample of patients, as it can not be estimated which numbers can be expected, but it is aimed to include at least 40 patients in the study (20 in the intervention group and 20 in the control group). specifically, the present study aims to 1. investigate early predictors (during icu-care) of post-covid syndrome occurring at 3-6 months, 12 months, and 36 months, respectively, including cognitive and mental health problems, 2. deepen the understanding of mental health symptoms in icu-treated covid-19 survivors, mental health-related treatment seeking, changes in addictive behaviors, and the diagnostic meaning of mental health symptoms expressed in covid-19 survivors, and 3. conduct a clinical treatment study with the following research question: for patients with post-covid mental health symptoms after 12 months, is an intervention of cognitive behavioral therapy (cbt) with acceptance and commitment therapy (act), when compared to standard clinical care (referral to primary care), feasible and associated with improved patient adherence and patient satisfaction, and secondly, does it improve the outcome of post-covid anxiety symptoms and secondary other symptoms of poor mental health and quality of life?

Eligibility criteria:
inclusion criteria: * covid-19 survivors who screen positive for clinical anxiety or depression, defined as reaching a score of ≥ 8 on either the anxiety or depression sub-scales within the questionnaire hads at the standard 12-months follow-up exclusion criteria: * conditions in which patients are acutely suicidal, psychotic, suffering from a mental disorder requiring in-patient psychiatric treatment, opposed to receiving a psycho-therapeutic intervention, or with cognitive problems or language difficulties which are judged to be too extensive for the informed consent procedure and for a psycho-therapeutic intervention

Keywords: covid-19 mental health disorder cognitive-behavioral therapy acceptance and commitment therapy addictive behavior icu
the effect of remote ischemic preconditioning on myocardial injury after noncardiac surgery

Conditions: Myocardial Injury; Non-cardiac Surgery; Remote Ischemic Preconditioning

Summary: this is a multicentre, parallel-group, randomised, sham-controlled, observer blinded trial, assessing the efficacy of remote ischemic preconditioning on preventing myocardial injury after noncardiac surgery.

this is a multicentre, randomised, sham-controlled, observer blinded trial. patients at high clinical risk for cardiovascular events and scheduled to undergo major abdominal surgery will be enrolled. a total of 766 patients are randomised (1:1 ratio) to receive ripc or no ripc (control) before anaesthesia induction. ripc will comprise four alternating cycles of cuff inflation for 5 min to 200 mm hg and deflation for 5 min. in controls, the identical looking cuff will be placed around the arm but not actually inflated for 40 minutes. the primary outcome was myocardial injury after surgery within three days of surgery. the secondary outcomes were peak plasma hs-ctnt and total hs-ctnt release during the first three days after surgery, hs-ctnt above the prognostically important thresholds, length of hospital stay after surgery, and length of stay in the intensive care unit, myocardial infarction, major adverse cardiovascular events, cardiac-related death and all cause death within 30 days, 6 months, 1 year and 2 years after surgery, postoperative morbidity and adverse events within 30 days after surgery. besides, blood samples were stored for the other ancillary studies.

Eligibility criteria:
inclusion criteria 1. patients at high clinical risk for cardiovascular events; 2. patients scheduled to undergo major abdominal surgery. exclusion criteria 1. immediate or urgent surgery or surgery where there is insufficient time to perform ripc. 2. abdominal vascular surgery, such as surgery for abdominal aortic aneurysm 3. experience of conditions precluding the use of ripc in both arms 4. patients who are being treated with drugs, such as sulphonamide or nicorandil 5. with contraindications for anaesthetic regimes required in this trial.
comparative clinical performance of 59% hioxifilcon a contact lenses vs. marketed hydrogel contact lenses

Conditions: Refractive Error - Myopia Bilateral

Summary: the study will compare the short-term clinical performance and wearer and practitioner acceptability of a new-to-market spherical daily disposable (dd) hydrogel soft contact lens to a currently marketed spherical dd hydrogel soft contact lens.

this randomized clinical trial will compare the short-term clinical performance, and wearer acceptability of a new-to-market hioxifilcon a spherical daily dd contact lenses against marketed dd lenses in a short cross-over clinical trial. the primary outcome variable for this study is overall subjective comfort.

Eligibility criteria:
inclusion criteria: * currently wearing spherical dd contact lenses at least 5 days/week * vision correctable to 20/30 acuity in each eye with spherical dd contact lenses * no ocular or systemic disease that contra-indicates soft contact lens wear exclusion criteria: * participating in another clinical trial * vision not correctable to 20/30
renin angiotensin system - coronavirus

Conditions: COVID 19

Summary: the aim of the study is to demonstrate overactivation of renin angiotensine system (ras) in positives covid-19 patient, especially in those with the most serious clinical forms where the mortality of patients in intensive care is on average 50%. we are expecting two groups: a group of 25 positive covid 19 patients in intensive care and a group of 25 positive covid 19 hospitalized patients in conventional hospitalisation. we will measure ras, serum potassium and collect data on the treatment of these patients (especially antihypertensive therapy) one week apart (at the patient'entry into hospital and 7 days later). this is a preliminary study that could possibly allow the start of a therapeutic trial in order to test the effectiveness of ras blocker treatments in this condition.


Eligibility criteria:
inclusion criteria: * positive covid 19 patients hospitalized in conventionnal hospitalisation * patients hospitalized in intensive care secondary to covid-19 : patient under invasive mechanical ventilation (pao2 / fio2 ratio \ = 5 cmh20; pcr sars-cov-2 positive in a pharyngeal or respiratory sample; pao2 / fio2 ratio\> 300) exclusion criteria: * minor patient * patient deprived of liberty * patient's refusal to participate in the study * patient for whom therapeutic limitation measures such as non-admission to intensive care have been issued
trochanteric bursal repair after a total hip replacement - are there benefits during the first 90 days

Conditions: Bursa; Tuberculous; Hip Bursitis; Deep Gluteal Syndrome; Hip Disease

Summary: during total hip arthroplasty surgery, the trochanteric bursa is routinely excised. this anatomical structure, which functions as a soft tissue barrier, is generally recommended for removal as it facilitates the surgical approach. however, recent studies have suggested that the trochanteric bursa is an important soft tissue barrier and may protect against infections. the aim of this study is to evaluate the differences in infection rates, wound complications, deep gluteal syndrome presence, pain, and clinical scores within the first 90 days between patients in whom the trochanteric bursa was repaired and those in whom it was not, and to provide recommendations regarding bursal repair.

during total hip arthroplasty surgery, the trochanteric bursa is routinely excised. this anatomical structure, which functions as a soft tissue barrier, is typically recommended for removal as it facilitates the surgical approach. however, recent studies have suggested that the trochanteric bursa is an important soft tissue barrier and may provide protection against infections. the aim of this study is to evaluate the differences in infection rates, wound complications, deep gluteal syndrome presence, pain, and clinical scores within the first 90 days between patients in whom the trochanteric bursa was repaired and those in whom it was not, and to provide recommendations regarding bursal repair. this research will be a prospective randomized controlled trial with patients subjected to sequential randomization. one group of patients will undergo the routine excision of the bursa during surgery, referred to as group 1. in the other group, the trochanteric bursa will be carefully retracted and subsequently repaired in its anatomical location beneath the fascia after the surgical procedure. wound closure will be performed routinely, with subcutaneous and skin closure. all patients will have a hemovac drain placed, and they will follow the same rehabilitation protocol. patients will be evaluated on postoperative days15, 30, and 90 using visual analog scale scores, and on days 30 and 90 using the harris hip score. additionally, patients will be assessed for tenderness on palpation, the presence of hip snapping (a sensation of the hip catching), hemoglobin drop, 90-day infection rates, and the presence of deep gluteal syndrome.

Eligibility criteria:
inclusion criteria: * patients between 18 to 90 years of age * with a diagnosis of primary hip osteoarthritis * willing to be included in the study exclusion criteria: * patients who had a known history of trochanteric bursitis, deep gluteal syndrome, sciatica, vertebral fracture, hip fracture, hip arthroscopy, and core decompression surgery * patients who had a history of bursal injection within 6 months * patients undergoing hip arthroplasty with a shortening osteotomy

Keywords: bursa greater trochanter hip arthroplasty deep gluteal syndrome piriformis syndrome
resiliency training for adults with neurofibromatosis via live videoconferencing

Conditions: Neurofibromatoses; Neurofibromatosis 1; Neurofibromatosis 2; Schwannomatosis

Summary: the aims of this study are to compare the effect and durability of two stress and symptom management programs tailored for patients with neurofibromatosis on quality of life and psychosocial functioning.

the aims of this study are to compare the effect of two stress and symptom management programs tailored for patients with neurofibromatosis on quality of life and psychosocial functioning. we will also examine the degree to which treatment-dependent improvements in quality of life are mediated by improvements in depression, anxiety, distress, mindfulness, gratitude, social support, empathy, optimism, coping, pain intensity and pain interference.

Eligibility criteria:
inclusion criteria: * has a diagnosis of nf1, nf2, or schwannomatosis * 18 years of age or older * is capable of completing and fully understanding the informed consent process, study procedures, and study assessments in english * at least 6th grade self-reported reading level * self-reported difficulties coping with stress and nf-symptoms * score of 6 or higher on perceived stress scale 4-item (pss-4) exclusion criteria: * has major medical comorbidity not nf related expected to worsen in the next 12 months * recent (within past 3 months) change in antidepressant medication * recent (within past 3 months) participation in cognitive behavioral therapy or relaxation therapy * has significant mental health diagnosis requiring immediate treatment (e.g., bipolar disorder, psychotic disorder, active substance use dependence) * unable or unwilling to complete assessments electronically via redcap * unable or unwilling to participate in group videoconferencing sessions

Keywords: psychiatry psychology psychosocial behavioral
plant stanols and type 1 diabetes

Conditions: Type 1 Diabetes

Summary: in type 1 diabetes (t1d) coronary artery disease (cad) is an important cause of morbidity and mortality. although serum cholesterol concentrations are not always elevated in t1d, cholesterol metabolism is different from non-diabetics, so that cholesterol absorption is enhanced. the aim of this study is to investigate the effects of plant stanol esters on serum lipid and lipoprotein lipid concentrations, plant sterol and cholestanol concentrations as well as cholesterol metabolism in t1 diabetics on statin use. the study will give new information about how addition of plant stanol esters on statin use improve hypolipidemic effects in type 1 diabetes.

in type 1 diabetes (t1d) coronary artery disease (cad) is an important cause of morbidity and mortality. although serum cholesterol concentrations are not always elevated in t1d, cholesterol metabolism is different from non-diabetics, so that cholesterol absorption is enhanced. thus, theoretically, the best way to reduce serum cholesterol concentrations is to reduce cholesterol absorption. however, statins are recommended to t1 diabetics at the same ldl cholesterol levels as for type 2 diabetics to reduce risk to cad. the aim of this study is to investigate the effects of plant stanol esters on serum lipid and lipoprotein lipid concentrations, plant sterol and cholestanol concentrations as well as cholesterol metabolism in t1 diabetics on statin use. altogether, twenty-four t1 diabetics (hba1c \<9%) on stabile statin use will be recruited to the study from an announcement in the local newspaper and from kuopio university hospital and harjula hospital. the study is carried out with a randomized, double-blind and parallel design. the intervention group (n=12) consumes spread enriched with plant stanol esters (3 g/d stanols) and the control group (n=12) the same spread containing no added stanols for 4 weeks. the fasting blood samples are taken at weeks 0, 3 and 4. from blood samples concentrations of serum lipids, squalene and non-cholesterol sterols will be analyzed.

Eligibility criteria:
inclusion criteria: * type 1 diabetes, stabile statin drug use, hba1c \<9% exclusion criteria: * liver, kidney and thyroid dysfunction, severe diabetic proteinuria, gastroparesis, unstable cad, unstable inflammatory gastrointestinal disease

Keywords: plant stanols type 1 diabetes sterol metabolism cholesterol