Kornimate/medical-research-clean huggingface dataset:
solifenacin succinate versus tolterodine 4mg once daily

Conditions: Urinary Bladder, Overactive

Summary: prospective, double-blind, double-dummy, 2-arm, parallel-group, design. flexible dose regimen for solifenacin succinate, fixed dose treatment regimen for tolterodine. assessment of oab symptoms by patient diaries.


Eligibility criteria:
inclusion criteria: at study entry: * patient is willing and able to complete the micturition diary correctly * symptoms of overactive bladder (including urinary frequency, urgency or urge incontinence) for \>= 3 months at randomization: * patient must experience frequency of micturition on average \>= 8 times per 24 hour period during the 3 day micturition diary period * patient must experience at least one of the following symptoms during the 3 day micturition diary period: * at least 3 episodes of urinary incontinence or, * patients must exhibit urgency at least 3 times exclusion criteria: at study entry: * pregnant women or women who intend to become pregnant during the study or women of childbearing potential who are sexually active and practising an unreliable method of birth control or will be lactating during the study. reliable contraceptive methods are intra-uterine devices, contraceptive pills of combination type, hormonal implants and injectable contraceptives * clinically significant outflow obstruction (at the discretion of the investigator) * significant post void residual volume (pvr\>200ml) * significant stress incontinence or mixed stress/urge incontinence where stress is the predominant factor as determined by the investigator * patient with a neurological cause for abnormal detrusor activity * evidence of a symptomatic urinary tract infection, chronic inflammation such as interstitial cystitis, bladder stones, previous pelvic radiation therapy or previous or current malignant disease of the pelvic organs * uncontrolled narrow angle glaucoma, urinary or gastric retention or any other medical condition which in the opinion of the investigator makes the use of anticholinergics contra-indicated * non drug treatment including electrostimulation therapy or start of a bladder training program during the 2 weeks prior to entry into, or during the study * use of drugs intended to treat urinary incontinence * diabetic neuropathy * known or suspected hypersensitivity to solifenacin, tolterodine, other anticholinergics or lactose * any clinically significant condition, which in the opinion of the investigator makes the patient unsuitable for the trial * participation in any clinical trial within 30 (90 in the uk) days prior to randomisation * employees of the yamanouchi group, third parties associated with the study, or the study site at randomization: * patient who did not complete the micturition diary according to the instructions * total daily urine volume \> 3000 ml as verified in the micturition diary

Keywords: overactive bladder
focused cognitive testing in inpatients

Conditions: Neurocognitive Disorders

Summary: neurocognitive disorder (ncd) affects over 116'000 people in switzerland and is frequently unrecognized and underdiagnosed. because missed and delayed diagnosis are associated with an increased burden of disease health service research has prompted a discussion about diagnostic guidelines and screening programs. some argue that screening for ncd in primary care is the optimal strategy to increase recognition rates; others consider test protocols implemented into hospital admission assessments as more justified. there is no distinct recommendation due to a lack of empirical data on the benefits and harms of cognitive testing yet. this trial strives to fill this gap and provide information about the benefits, harms and the economic case of routine cognitive testing for neurocognitive disorder in high risk elective inpatients, in switzerland. the investigators hypothesize that, cognitive tested patients, compared with patients not cognitive tested, will have higher health-related quality of life at 12months; and lower medical health care costs at 18months.


Eligibility criteria:
inclusion criteria: * elective inpatients, living in the canton of lucerne, high risk of developing a major neurocognitive disorder, living at home exclusion criteria: * known mental disorder according to icd-10, chapter v, excluding f32 \& f33, patients with terminal illness, patients of intensive care unit or oncology patients, no adequate vision or hearing, no ability to speak, write or to understand german, no informant, antidementia medication

Keywords: dementia dementia screening general hospital inpatients
effects of automated adjustment of fio2 on cerebral and arterial oxygenation in preterm infants

Conditions: Preterm Infant; RDS

Summary: in this study the investigators test the hypothesis that automated fio2 adjustment increases the time of brain tissue oxygenation within the intended reference range. furthermore, the investigators studied the change in workload during automated fio2 adjustment as compared to manual adjustment by the nursing staff.

recorded data on brain tissue oxygenation will be compared with reference data obtained from other studies. data from experimental mode (automated fio2 control will be compared with manual fio2 control).

Eligibility criteria:
inclusion criteria: * postmenstrual age \<30 wks ga at study time * on nasal/nasopharyngeal cpap or mechanical ventilation (including nasopharyngeal imv) * at least 4 desaturations (spo2 \<80%) during an 8 hour period within the 24h before the study using a standard pulse oximeter incorporated in the nicu (dash 3000, general electric, freiburg; 10s averaging time, delay 10s) exclusion criteria: * postnatal age \<96h (to exclude rapidly changing conditions during the early phase of rds and to avoid handling of the infant during the critical period for ivh) * congenital cyanotic heart disease * no decision for full treatment support * average fio2 during the last 24h bevor the active study phase \>0.60 * congenital malformations of the lung or the diaphragm (i.e. diaphragmatic hernia, congentital cystic lung diseases...) * clinically clear evidence for seizures * ongoing sepsis (crp \> 10mg/l, or positive blood culture, requirement of catecholamines) * need of blood-transfusion during study
time course of procalcitonin and c reactive protein in septic patients under treatment with corticosteroids

Conditions: Sepsis

Summary: a systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. since the production of crp is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute phase protein will: 1. suggest attenuated systemic inflammation, but 2. does not necessarily reflect adequate therapy of the infection. for several reasons (good diagnostic tool for sepsis, induction not decreased by immunosuppressive therapy), procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids. as this issue has not yet been examined the investigators will prospectively study the time-course of ptc and crp in a well-defined septic patient group, that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment.


Eligibility criteria:
inclusion criteria: * acute exacerbation of chronic obstructive pulmonary disease (copd) due to bacterial pneumonia exclusion criteria: * chronic systemic use of corticosteroids

Keywords: procalcitonin sepsis corticosteroids
molecular assessment of artemisinin resistance markers in eastern and western border areas of myanmar

Conditions: Day-3 Positive of Parasitaemia; Prevalence of Drug Resistance Gene Mutation

Summary: * artemisinin resistance have been documented in myanmar and myanmar artemisinin resistance containment measures have been launched since 2009-2010. * it is important to monitor the spread and magnitude of artemisinin resistant malaria in myanmar. * so, day-3 surveillance study have been conducted. * recently artemisinin resistant molecular marker, k13 have been identified and it was used as a tool in this study.


Eligibility criteria:
inclusion criteria: * confirmed uncomplicated falciparum malaria patients. * age \>2 years * box sex * given informed consent exclusion criteria: * severe malaria * did not give informed consent * others diseases

Keywords: malaria k13 pfmrp1 myanmar
international melanoma algorithm training study - imats

Conditions: Malignant Melanoma

Summary: this is an international, multicenter, prospective, non controlled, non randomized, clinical study to collect electrical impedance data of potentially malignant pigmented nevi and histological diagnoses (international melanoma algorithm training study \[imats\]). the study objective is to collect data for training and optimization of an algorithm that can classify skin lesions using electrical impedance, i.e., to identify malignant melanomas.


Eligibility criteria:
inclusion criteria: * men and women of any ethnic group * lesion located on normal healthy skin * maximum number of eight lesions per patient * etc. exclusion criteria: * lesion under finger and toe nails * lesion located on eczema, psoriasis areas or similar * lesion located on scars * etc.
arterial calcifications in nocturnal hemodialysis and renal transplantation versus conventional dialysis

Conditions: Kidney Disease

Summary: objective: 1. to assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; 2. to identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

to assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; to identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Eligibility criteria:
inclusion criteria: * esrd * current age \> 18 and \< 75 yr * ability to understand the study procedures * willingness to provide written informed consent exclusion criteria: * life expectancy \< 3 months * claustrophobia * allergy to iodinated contrast * treatment incompliance, i.e. non-adherence to dialysis regimens and drug use * gfr \< 30 ml/min (according to mdrd formula) in renal transplant patients * pregnancy

Keywords: cardiovascular disease endstage renal disease
adipose tissue inflammation in individuals undergoing bariatric surgery

Conditions: Obesity, Morbid; Bariatric Surgery Candidate

Summary: a growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)." importantly, these secreted factors enter into the circulation and have paracrine and autocrine actions, which profoundly impact systemic metabolism (e.g., insulin sensitivity). additionally, in animals, loss of ovarian hormone production via ovariectomy (similar to menopause in humans) leads to increases in both in adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy than that from premenopausal animals. to date, no studies have investigated the effect of menopause on abdominal fat in overweight individuals. knowing if adipose tissue-specific changes occur with menopause may potentially lead to recommendations or therapeutics to improve women's health post menopause.

subjects will just have to agree to having a small amount of adipose tissue being removed during the bariatric surgery. the investigators will also collect a blood sample at that time. there will be no other visits for the subject.

Eligibility criteria:
inclusion criteria: * women who are premenopausal or who are postmenopausal and have been for at least one year. males will be recruited to age match female subjects. all subject are already scheduled to have bariatric surgery at the university of missouri-columbia department of surgery. exclusion criteria: * women who are perimenopausal. women who are on hormone replacement therapy.
life experience of people aged 60 and over living with hiv

Conditions: Virus-HIV

Summary: the purpose of this study is to assess the impact of hiv on the life course of patients aged 60 and over.

corevih idf nord and cermes3 conducted a first qualitative survey of 32 hiv patients aged 60 and over. the study, in the form of an individual interview, aimed to identify the difficulties that plwhiv may encounter in their life course, to question their future and the impact that hiv could have. from this study, a questionnaire was drawn up covering the points raised by the qualitative study. the questionnaire was designed by doctors of the four hospitals that participated in the first study and a sociologist from cermes3. after patient's oral agreement obtained, the study questionnaire "sociological study pvhiv ≥ 60 years" will be given to the patient for completion.

Eligibility criteria:
inclusion criteria : people aged 60 and over living with hiv and view in consultation patient participation agreement obtained exclusion criteria : people living with hiv less than 60 years old

Keywords: vih living with hiv 60 years old and over
efficacy and economic evaluation of nonbiological artificial liver therapy in acute-on-chronic hepatitis b liver failure.

Conditions: Chronic-on-acute Liver Failure

Summary: this was a non-blinded, prospective clinical study. from june 2020 to october 2021, 254 patients with hbv-aclf were treated at the department of infectious diseases, xiangya hospital, central south university (changsha, china). 186 patients who met the enrollment criteria were included in this study. inclusion criteria were as follows: (1) aged 18-65 years old; (2) patients with aclf caused by hbv infection; (3) meeting the diagnostic criteria for aclf by the asian pacific association for the study of liver (apasl).the exclusion criteria were as follows: (1) pregnancy or lactation; (2) previous liver transplantation; (3) hepatocellular carcinoma or other malignancy; (4) human immunodeficiency virus(hiv) infection or other immunocompromised states; (5) complicated with underlying diseases such as severe heart, respiratory, and blood system diseases. based on the inclusion and exclusion criteria, the investigators randomly matched patients at a 1:1:1 ratio to three groups whose age, sex ratio, complication, and liver function were comparable: comprehensive medical treatment (control group), pe group, and dpmas plus half-dose sequential pe (dpmas + pe group). as a result, 62 subjects per group were recruited into the study. this study was approved by the clinical research ethics committee of xiangya hospital, central south university with informed content obtained from all participants (no. 202201022). the study protocol followed the principles of the helsinki declaration strictly. all the 186 patients enrolled received comprehensive medical treatment after admission to the hospital, including anti-viral treatment, general supportive treatment, supplementation of blood products, such as albumin and plasma, and symptomatic treatment.


Eligibility criteria:
inclusion criteria: * aged 18-65 years old * patients with aclf caused by hbv infection * meeting the diagnostic criteria for aclf by the asian pacific association for the study of liver. exclusion criteria: * pregnancy or lactation * previous liver transplantation * hepatocellular carcinoma or other malignancy * human immunodeficiency virus(hiv) infection or other immunocompromised state * complicated with underlying diseases such as severe heart, respiratory, and blood system diseases
the effect of interactive multimedia versus illustrated booklet on behavior to prevent lower back pain in working nurses.

Conditions: Low Back Pain

Summary: the present study was conducted to compare the effect of interactive multimedia and illustrated booklet methods on knowledge, attitude and improvement of behavior in preventing lower back pain amongst lower back pain amongst nurses.

in this single blind randomized controlled trial, 153 eligible nurses working in hospitals during 2019 were enrolled. the participants were randomly allocated into three parallel groups: interactive multimedia (n=55), illustrated booklet (n= 55), and the control (n= 43). the study samples were blinded to intervention and control groups. a researcher-made questionnaire was completed by the eligible subjects before, after, and four weeks after the intervention to assess their knowledge, attitude and behavior in preventing chronic lower back pain amongst working nurses.

Eligibility criteria:
inclusion criteria: * minimum education level of bachelor's degree in nursing * employment in governmental hospitals * willing to participate in the study and complete the informed consent * minimum knowledge of working with computers exclusion criteria: * congenital anomalies * low back pain * history of back surgery * history of trauma to the back * pregnancy * severe osteoporosis
tvt-secur versus tvt-obturator: a randomized trial of suburethral sling operative procedures

Conditions: Stress Urinary Incontinence

Summary: the purpose of this study is to determine whether tvt-secur (tvt-s) (hammock method) and tvt-obturator (tvt-o) suburethral sling procedures have equivalent patient satisfaction and clinical efficacy in the treatment of stress urinary incontinence alone or the stress component in mixed urinary incontinence.

patient satisfaction will be measured by symptom quality of life questionnaires (pre-operatively, 3 months and one year) and patient pain will be measured by verbal analogue rating scale (post-operative day 1 and day 7). clinical efficacy will be measured by a cough stress test pre-operatively and post-operatively at 3 months and 1 year. a q-tip test will also be performed pre-operatively and at 3 months and 1 year post-operatively. subjects will be followed for a minimum of one year to evaluate recurrence of symptoms and complications, including the rate of mesh erosion, time to normal void in the post-operative period, the rate of sling revision, post-operative pain, voiding dysfunction and de novo urgency.

Eligibility criteria:
inclusion criteria: * are at least 18 years of age * demonstrate a positive cough stress test during complex multi-channel urodynamic testing * demonstrate impact of stress urinary incontinence on quality of life questionnaire * are able to comprehend and sign a written informed consent * understand and are willing to comply with the study requirements, including agreeing to be available for the follow-up evaluations * are psychologically stable and suitable for interventions determined by the investigator * are ambulatory and able to use a toilet independently exclusion criteria: patients: * who are pregnant or planning to become pregnant during the study or in the future * with a elevated post-void residual (defined as pvr \> 100cc) * with a bleeding condition or on anti-coagulant therapy * with immunosuppression (i.e. hiv, lymphoma) * with multiple sclerosis or other progressive neurological disease * with evidence of a local or systemic infection, including urinary tract infection * with evidence of intrinsic sphincter deficiency as defined by a maximal urethral closure pressure of \<20 cm h2o * previous sub-urethral sling * predominant overactive bladder symptoms
neurodevelopmental and growth outcomes of early, aggressive protein intake in very low birthweight infants

Conditions: Prematurity

Summary: the purpose of this study is to determine whether providing increased protein to premature infants in the first week of life allows for better growth during the hospital stay and improved developmental outcomes by age 2.


Eligibility criteria:
inclusion criteria: * birth weight 400 to 1250 grams * 24 0/7 to 30 6/7 weeks gestational age exclusion criteria: * chromosomal, structural, metabolic, endocrine, or renal abnormalities that could affect growth * infants \>18 hours of age * infants in extremis who are unlikely to survive past 72 hours

Keywords: amino acids protein
formulation-based cbt for adult inmates with adhd: a randomized controlled trial

Conditions: Attention Deficit Hyperactivity Disorder

Summary: background recent literature suggests that adhd is a risk factor for the development of antisocial behavior that is more severe and persistent than in community and other psychiatric populations. the combination of stimulant medication and psychotherapy (particularly cognitive-behavioral therapy, cbt) is considered an evidence-based intervention for adults with adhd. in contrast, few studies have evaluated the efficacy of medication in adult prisoners with adhd, and the literature on the efficacy of psychotherapy is virtually nonexistent. therefore, this article presents the protocol of a trial that will assess the efficacy of a formulation-based cbt program for inmates with adhd. methods the study has a multicenter randomized controlled trial design. after screening and recruitment, participants will be randomly assigned to the cbt intervention, a general offender treatment program, or a waitlist. pre- and post-treatment self-report and clinician-report assessments, as well as 6- and 12-month follow-up assessments will be conducted. these will include both clinical (e.g., adhd symptoms, depression and anxiety symptoms, self-esteem, alcohol/drug abuse, treatment adherence, quality of life) and criminological (e.g., recidivism and risk of recidivism) measures. linear mixed models will be used to assess differences between groups. discussion this study may be the first to evaluate the efficacy of a psychotherapy intervention in adult inmates with adhd. it is expected that addressing the specific needs of adhd would not only result in the previously reported clinical improvements (e.g., reduction in adhd and comorbidity symptoms), but also reduce the risk and rate of recidivism compared to the general intervention or no intervention. however, the design may be limited by the difficulties inherent in the prison setting and in following up the sample after release.


Eligibility criteria:
inclusion criteria: * to have signed written informed consent to participate in the study * to be between 18 and 65 years of age * to meet the dsm-5 diagnostic criteria for adhd (american psychiatric association, 2013) * to have been convicted of at least one crime under spanish or german criminal law * to have been incarcerated for at least six months and three or fewer years since the completion of the conviction at the time of eligibility assessment. exclusion criteria: * to have a severe personality disorder, psychotic disorder, or pervasive developmental disorder as their primary diagnosis, as the intervention would not meet their clinical needs * to have an iq of 80 or less, as measured by a standardized iq test (raven et al., 1993), due to the complexity of the cognitive components in the cbt program * to have participated in a previous psychological intervention for adhd; * to not be fluent in spanish or german, depending on the study site.