Kornimate/medical-research-clean huggingface dataset:
exercise rehabilitation of younger and older people with claudication

Conditions: Intermittent Claudication

Summary: the purpose of this study is to examine the effect of age and the effect of exercise intensity of rehabilitation programs on claudication pain symptoms and leg circulation of younger and older patients with intermittent claudication.

thirty-one patients randomized to low-intensity exercise rehabilitation and 33 patients randomized to high-intensity exercise rehabilitation completed the study. the 6-month exercise rehabilitation programs consisted of intermittent treadmill walking to near maximal claudication pain three days per week at either 40% (low-intensity group) or 80% (high-intensity group) of maximal exercise capacity. total work performed in the two training regimens was similar by having the patients in the low-intensity group exercise for a longer duration than patients in the high-intensity group. measurements of physical function, peripheral circulation, and health-related quality of life were obtained on each patient before and after the rehabilitation programs.

Eligibility criteria:
inclusion criteria: * history of intermittent claudication * exercise tolerance limited by intermittent claudication during a screening treadmill test * ankle/brachial index (abi) at rest less than 0.90 * live independently at home exclusion criteria: * absence of pad (peripheral artery disease) * asymptomatic pad (fontaine stage i) * rest pain pad (fontaine stage iii) * exercise tolerance limited by factors other than claudication (e.g., coronary artery disease, dyspnea, poorly controlled blood pressure) * active cancer, renal disease, or liver disease * current use of pentoxifylline or cilostazol medications for the treatment of intermittent claudication

Keywords: functional ability gait musculoskeletal disorder therapy peripheral blood vessel disorder
effects of n-acetylcysteine on low t3 syndrome

Conditions: Acute Myocardial Infarction; Euthyroid Sick Syndrome; Ischemic Heart Disease

Summary: the propose of this study is to determine whether n-acetylcysteine is effective in reversing the changes in thyroid hormones seen in critical illness, known as the low t3 syndrome.

the low t3 syndrome or nonthyroidal illness is characterized by low levels of t3, normal or high normal levels of rt3, low or normal levels of t4 and inappropriately normal or low levels of tsh. these changes affect up to 75% of patients and have prognostic implications. interleukin-6 (il6) seems to have a causative role in the pathogenesis of nonthyroidal illness. there is evidence that the reduction in serum t3 was inversely associated with serum il-6, while the rt3 have a positive association. the mechanism of action of cytokines on the metabolism of thyroid hormones has not been determined and the potential role of cytokines on the deiodases has been the focus of research. in a cell culture model study, il-6 was able to suppress the conversion of t4 to t3 by deiodases type 1 and 2 and stimulate the inactivation of t3 by deiodase type 3, a situation similar to nonthyroidal illness. the use of n-acetylcysteine prevented this alterations, been consistent with the hypothesis that il6 inhibits the function of the deiodases by increasing the oxygen reactive species and by consuming gluthathione or some gluthathione dependent cofactor. considering the absence of human studies evaluating the use of n-acetylcysteine in nonthyroidal illness, the aim of this study is to investigate whether nac has in vivo effect on changes of thyroid hormones.

Eligibility criteria:
inclusion criteria: * diagnosis of acute myocardial infarction with less than 12 hours of evolution * reperfusion therapy (primary angioplasty) exclusion criteria: * thyroid disease * chronic renal disease with renal replacement therapy * hepatic insufficiency * immunosuppression

Keywords: euthyroid sick syndrome low t3 syndrome deiodases oxidative stress ischemic heart disease
clinical trial of adjuvant chemotherapy followed by concurrent chemoradiotherapy compared with adjuvant chemotherapy alone in patients with gallbladder carcinoma and extrahepatic cholangiocarcinoma

Conditions: Malignant Neoplasm Other Gallbladder/Extrahepatic Bile Duct

Summary: the present study is designed to determine whether adjuvant concurrent chemoradiotherapy improves overall survivals.

the role of adjuvant radiotherapy in gallbladder carcinoma (gbca) or extrahepatic cholangiocarcinoma (ehcc) is unknown. a retrospective study suggested that chemoradiotherapy provides greater benefit than chemotherapy alone in gbca patients. swog s0809, a phase ii study showed that adjuvant chemoradiotherapy has promising efficacy in gbca or ehcc. the present phase iii clinical trial is designed to compare adjuvant concurrent chemoradiotherapy with chemotherapy alone.

Eligibility criteria:
inclusion criteria: * the patients with pathologic diagnosis of gallbladder carcinoma (gbca) or extrahepatic cholangiocarcinoma (ehcc) after radical resection. * the patients with pathologic stage t2-4 or n1 in r0 resection or positive resection margins (r1). * aged 18 to 70 years old, male or female, body condition score generally ecog 0～2, expected survival ≥ 6 months. * subjects were no major organ dysfunction, blood, liver, kidney and heart function was normal, the specific requirements of laboratory indicators: * blood: absolute neutrophil count \> 1.5 × 109 / l, platelet count \> 100 × 109 / l, hb \> 8.0g/dl. * liver function: serum bilirubin less than 1.5 times the upper limit of normal; alt and ast less than 2.5 times the upper limit of normal. * renal function: creatinine less than 1.5 times the upper limit of normal. * patients who can understand the circumstances of this study and signed informed consent. exclusion criteria: * pregnancy, breast-feeding patients； * patients received prior anticancer therapy for the current malignancy or upper abdominal radiotherapy or chemotherapy at any time. * patients with malignant ascites. * patients with purulent and chronic infected wounds which delayed healing. * patients with liver, kidney and heart failure and coronary heart disease, angina, myocardial infarction, arrhythmia, cerebral thrombosis, stroke and other serious cardiovascular and cerebrovascular disease; * patients has a history of mental illness and difficult to control; * patients who was considered inappropriate to participate in the trials by the researchers.

Keywords: gallbladder carcinoma extrahepatic cholangiocarcinoma chemoradiotherapy
efficacy evaluation and influencing factors of argon laser peripheral iridoplasty in acute angle closure glaucoma

Conditions: Acute Angle-Closure Glaucoma

Summary: to investigate the changes of angle structure and intraocular pressure after argon laser peripheral iridoplasty in patients with acute angle closure glaucoma patients whose intraocular pressure could not be controlled by drug therapy during the major attack period.

to evaluate intraocular pressure and anterior segment optical coherence tomography measurement parameters at baseline and each follow-up. each patient was followed up for 6 weeks for 9 times. visit 1st was baseline examination, visit 2nd was 1 hour after argon laser peripheral iridoplasty treatment, visit 3rd was 2 hours after argon laser peripheral iridoplasty treatment, visit 4th was 1 week after argon laser peripheral iridoplasty treatment, visit 5th was 2 week after argon laser peripheral iridoplasty treatment, and visit 6th was 1 month after argon laser peripheral iridoplasty treatment, visit 7th was 6 week after argon laser peripheral iridoplasty treatment.

Eligibility criteria:
inclusion criteria: * one eye had an acute attack, which could not be relieved by medication, and the intraocular pressure was more than 21mmhg; * the patients were 40 to 80 years old, regardless of gender; * patients are able and willing to comply with the research guidance and may complete all visits required by the research; * informed consent has been signed. exclusion criteria: * history of ocular trauma; * any previous intraocular surgery; * secondary glaucoma was diagnosed, including uveitis, neovascular glaucoma, glaucoma with elevated superior scleral venous pressure, lens dissolution glaucoma, glaucoma caused by lens dislocation, lens cortical glaucoma, pigmented glaucoma, etc; * the patient's history indicated that he had severe dysfunction of heart, lung, liver and kidney; * women in pregnancy, lactation or planned pregnancy; * the researchers believe that the patient's condition may put the patient at a significant risk, may confuse the results of the study, or may significantly interfere with the patient's participation in the study.

Keywords: acute angle-closure glaucoma argon laser peripheral iridoplasty
impact of peripheral afferent input on central neuropathic pain

Conditions: Spinal Cord Injuries; Spinal Cord Diseases; Syringomyelia

Summary: the overarching aim of this study is to investigate the contribution of peripheral afferent input to spontaneous and evoked central neuropathic pain after a spinal cord lesion or disease.

a key question that has been subject to longstanding debates in the field relates to the sites and mechanisms within the peripheral or central nervous system that potentially perpetuate chronic spontaneous and evoked central neuropathic pain. the investigators hypothesize that spontaneous central neuropathic pain depends on continuous, "physiological" somatosensory input from the painful body region in the periphery. thus, spontaneous central neuropathic pain results from pathological gain control in central somatosensory networks with decreased activation thresholds for thermo- and mechanosensitive peripheral afferents.

Eligibility criteria:
inclusion criteria: * definite central neuropathic pain according to current diagnostic algorithms involving at least both feet or both hands bilaterally and symmetrically with regard to the expected neuroanatomical distribution of the nerve block. * patients with spinal cord injury. for patients with pain in both legs, the injury has to be incomplete. for patients with pain in both arms, the injury can be complete or incomplete. the pain in the area that will be investigated (region of interest) has to be in an area with at least some preservation of sensation * an intensity of spontaneous pain of ≥4 nrs \[0-10\] in the region of interest during the screening visit and at the day of the intervention. * participant is able and willing to give informed consent. * for female subjects of childbearing potential: a negative pregnancy test and either use of highly effective contraception or sexual abstinence exclusion criteria: * conus/cauda involvement or evidence of peripheral neuropathic pain due to documented peripheral lesion. * other known neurological and psychiatric conditions * history or symptoms of significant diseases that may confound the measurements or represent contra-indications for the intervention (e.g., neuropathy following cancer or metabolic diseases such as diabetes mellitus, liver diseases, and kidney diseases. * cardiovascular diseases that preclude the anaesthetic intervention (e.g., arrythmias). * concomitant nociceptive pain within the innervation territory of the planned nerve block. * unable to understand and speak danish * changes in pain medication within the last 4 weeks prior to the intervention. * treatment with warfarin or other blood thinning medications, that contraindicates regional anesthesia if the treating physician cannot recommend that such treatments are paused for at least 7 days before the study day * infection or skin disease in planned injection area * allergy for local anesthetics * pregnancy or lactation. * alcohol or drug abuse * pain intensity below 4 in the region of interest at the baseline measurement before the nerve block

Keywords: central pain peripheral afferent input neuropathic pain spinal cord injury
topical gw842470x in adults patients with moderate atopic dermatitis

Conditions: Atopic Dermatitis; Dermatitis, Atopic

Summary: the purpose of this study is to investigate the clinical efficacy of 3% (w/w) gw842470x cream applied to involved skin of adult patients with moderate atopic dermatitis using the eczema area severity index (easi) assessment of disease severity and to investigate the safety of and tolerability of 3% gw842470x cream on diseased skin of adult patients.


Eligibility criteria:
inclusion criteria: * moderate atopic dermatitis patients (iga=3). * the disease involvement must be \>5% of body surface area. * female patients of child-bearing potential must use an appropriate method of contraception. exclusion criteria: * patients with any active skin disease other than atopic dermatitis will not be eligible. * patients who have had systemic treatment for atopic dermatitis or other topical or transdermal treatments (such as nicotine, hormone replacement therapies) within 14 days prior to first application of study medication and/or topical treatment with tar, any corticosteroid, topical immunomodulators or oral treatment with any corticosteroids within 10 days prior to first application and/or oral anti-histamines within 5 days of the first dose.

Keywords: atopic dermatitis gw842470x pde4 inhibitor
retrospective study of long-term survival of "immuncell-lc" in patients undergoing curative resection for hcc in korea

Conditions: Hepatocellular Carcinoma

Summary: to observation that long term follow-up study of 'immuncell-lc groups' and 'non-treatment groups' in patient undergo curative resection (peit, rfa or operation) for hepatocellular carcinoma in korea

the purpose of this study is to retrospectively compare the long-term survival of patients who participated in the "randomized, open-label, multicenter phase 3 clinical trial to evaluate the efficacy and safety of immunocel-lc treatment and no treatment in korean patients with hepatocellular carcinoma (hcc) who received potentially curative treatment \[surgical resection, radiofrequency ablation (rfa), or percutaneous ethanol injection (pei)\] (nct00699816). hcc was diagnosed by pathological evaluation or radiological imaging studies. eligibility criteria also included hepatic function of child-pugh class a and an eastern cooperative oncology group performance status score of 0 or 1. exclusion criteria included autoimmune disease or immunodeficiency, previous or current malignant tumor other than hcc, and severe allergic disorders. pregnant or breastfeeding women and women planning to become pregnant were also excluded. all eligible participants were randomly assigned to receive adjuvant immunotherapy using a cik cell agent (the immunotherapy group) or no adjuvant treatment (control group) in a 1:1 ratio.

Eligibility criteria:
inclusion criteria: * patients of participated in the(clinicaltrials.gov identifier:nct00699816)clinical trial. exclusion criteria: * na
evaluation of mindfulness and yoga in basic combat training

Conditions: Depressive Symptoms; Anxiety; Sleep; Emotion Regulation; Pain; Military Operations; Cohesion, Social; Mindfulness; Yoga; Leadership; Health, Subjective; Stress; Mood; Musculoskeletal Injury

Summary: the present study is a group randomized trial assessing the impact of mindfulness and yoga training on the health, performance, and well-being of soldiers in basic combat training (bct). randomization occurred at the platoon level, and platoons received either a combined mindfulness and yoga regimen or training as usual.

this program evaluation assessed a training initiative developed and implemented by the u.s. army training and doctrine command. four surveys were conducted with soldiers in all participating platoons over the course of bct, and two additional surveys were administered with those soldiers in the mindfulness and yoga intervention condition. a follow-up survey was distributed to all participants 6-12 months after bct. in addition, two surveys were conducted with bct cadre and drill sergeants. army data reflecting performance, attrition, and health were also obtained for analysis.

Eligibility criteria:
inclusion criteria: * u.s. army soldiers participating in basic combat training from oct - dec 2020 at a u.s. army installation in the southeastern united states. exclusion criteria: * none

Keywords: military basic combat training soldier drill sergeant mindfulness-based attention training
hypertonic saline (6%) versus isotonic saline (0.9%) in bronchiectasis

Conditions: Bronchiectasis

Summary: the investigators hypothesise that nebulised hypertonic saline (6%) will increase the volume of sputum expectorated over a 24 hour period compared to nebulised isotonic saline (0.9%) in patients with mild to severe stable bronchiectasis.


Eligibility criteria:
inclusion criteria: * non cf bronchiectasis * 18-80 years * fev1 less than 90% * chronic sputum production * clinical stable exclusion criteria: * intolerance to hts * use of htsaline or antibiotics 14 days prior to study * clinically unstable * smokers

Keywords: bronchiectasis hypertonic saline
impact of air pollution on chronic respiratory diseases

Conditions: Chronic Obstructive Pulmonary Disease; Asthma; Idiopathic Pulmonary Fibrosis

Summary: the aim of this study is to evaluate the impact of air pollution on the occurrence and clinical course of chronic respiratory diseases, and discover new biomarkers from various devices such as ct images that can indicate the process and amount of lung damage caused by air pollution. accordingly, the investigators have designed an prospective cohort with enrollment of normal people and patients with chronic respiratory diseases of three different categories (chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis). participants will be followed up for a period of one year, with evaluation of the clinical course of the respiratory disease and exposure to air pollution.

normal people (n=90) and patients with chronic respiratory diseases (chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, n=90 for each disease) will be enrolled at 5 different institutions in south korea and followed up for one year. inspiratory-expiratory cts and tests including physical examination and blood/urine tests would be performed at the time of enrollment and the time at completion of the follow up period for each participant. participants would be checked for the residency and working places, as well as checked for the amount of air pollution exposure using a wearable measurement device for 5 days during the study period ( time at enrollment / 3 months / 6 months / 9 months / time at completion). the device would cause no effect on usual daily life or the medical status of the participant. the clinical course such as occurrence of disease, acute exacerbation, decline of lung function, imaging status, mortality would be evaluated as well as the exposure of air pollution for each individual.

Eligibility criteria:
inclusion criteria: * normal: people with no lung lesions in chest x-ray and st. george's respiratory questionnaire score \ = 0.7 and fev1 \>= 80% and fvc \>= 80%. * chronic obstructive pulmonary disease: patients with over 10 pack-years of smoking history and post bronchodilator fev1/fvc \<0.7 and fev1 \< 80%, and no other reason for decline of lung function. * asthma: patients with fev1/fvc \< 0.85 and increase in over 12% and 200ml of fev1 by bronchodilator inhalation. patients with p20 \< 16mg/dl by bronchial provocation test. * idiopathic pulmonary fibrosis: shows usual interstitial pneumonia according to chest ct and has no other reasons such as systematic diseases or medication history. exclusion criteria: * subjects who refused for enrollment in the study * subjects who experienced an acute exacerbation within 1 month. * subjects under age of 19.
effect of remote ischemic preconditioning on children undergoing cardiac surgery

Conditions: Cyanosis

Summary: this study is conducted in order to evaluate the effect of remote ischemic preconditioning on children undergoing cardiac surgery, especially focusing on possible differences according to preoperative cyanosis.


Eligibility criteria:
inclusion criteria: * open heart surgery under cardiopulmonary bypass: ventricular septal defect, tetralogy of fallot exclusion criteria: * chromosomal defect * airway and parenchymal lung disease blood disorder * isolated atrail septal defect * immunodeficiency

Keywords: troponin, open heart surgery, children
developing and evaluating product messaging

Conditions: Cancer of Colon; Cancer of Rectum

Summary: purpose: to assess the impact of taxes, warnings, and a combination of taxes and warnings on us adults' decisions to purchase products that contain red meat in an online grocery store. procedures (methods): participants will be recruited from prime panels (an online panel research company). following online consent, participants will be assigned to one of four trial arms: 1) control (no warning and no tax), 2) warnings (all products that contain red meat have a health warning and environmental warning), 3) tax (30% tax on products that contain red meat), and 4) combined warning and tax (all products that contain red meat will have the two warnings and a 30% tax). then, participant will enter an online grocery store reflecting their assigned arm. the participant will be instructed to complete a shopping task in the online grocery store. after completing the shopping task, participants will be redirected to an online survey and answer a series of questions about the shopping task, labels (excluding tax and control groups), and taxes (excluding warning and control groups). questions will also include standard demographic and health related variables.

participants will be recruited from prime panels (an online panel research company). following online consent, participants will be randomly assigned to one of four trial arms affecting the appearance of an online grocery store. once in the online grocery store, participants will complete a shopping task. the participants will have 9 specified items to add to their shopping cart (1 pizza, 1 burrito, burger patties \[meat or vegetarian\], breakfast sausages \[meat or vegetarian\], 1 frozen individual meal, 1 loaf of bread, 1 sandwich filling \[for example, ham, turkey, or peanut butter\], 1 pack of tortillas, 1 taco filling \[for example, steak, chicken, or beans\]). participants will be informed that they will not be spending any of their own money to complete the shopping task. after completing the shopping task, participants will be redirected to a survey. they will provide self-reported responses to survey questions (e.g. perceived healthfulness from eating red meat, perceived risk of cancer from eating red meat, thinking about the health/environmental harms of food products). participants will also answer demographic and health related questions.

Eligibility criteria:
inclusion criteria: * 18 years or older * consumes red meat at least once per week. * responsible for at least 50% of grocery shopping for the household. * lives in the united states exclusion criteria: * individuals who have participated in research studies from previous aims of this research.