Kornimate/medical-research-clean huggingface dataset:
use of a pre-surgical toolkit in improving surgical care and outcomes in older participants with cancer

Conditions: Malignant Neoplasm; Surgical Procedure, Unspecified; Health Care Provider; Carcinoma

Summary: this trial studies how well the use of a pre-surgical toolkit (opti-surg) works in improving surgical care and outcomes in older participants with cancer. in many elderly patients, surgery can greatly affect physical condition and the ability to return to pre-surgery levels of physical functioning. providing pre-surgical recommendations may help improve participants' recovery rate and functioning after surgery.

primary objectives: i. to compare 8-week postoperative function among elderly patients between sites randomized to implement the opti-surg toolkit with or without a coach versus sites randomized to usual care. secondary objectives: i. to compare postoperative morbidity between sites randomized to implement the opti-surg toolkit with or without a coach versus sites randomized to usual care. ii. to compare the penetration of the opti-surg toolkit between sites randomized to implement the opti-surg toolkit with a coach versus sites randomized to implement the opti-surg toolkit without a coach. trial design: outline: healthcare providers/institutions are randomized to 1 of 3 arms. patients/participants receive the intervention based on which arm their healthcare provider is in. arm i: healthcare providers/institutions perform usual care. arm ii: healthcare providers/institutions receive opti-surg training and informational materials. arm iii: healthcare providers/institutions receive opti-surg training and informational materials and meet with a coach. after conclusion of study, participants are followed up at 8 and 12 weeks post surgery, and healthcare providers/institutions are followed up 6-9 months after the last patient is registered.

Eligibility criteria:
inclusion criteria: * patients must have known or suspected cancer diagnosis and have one of the following cancer-directed operations planned: * gastrectomy * colectomy * proctectomy * esophagectomy * pancreatectomy * hepatectomy * total cystectomy * partial or total nephrectomy * lung lobectomy/pneumonectomy * patients with known metastatic disease with a plan for curative intent resection are eligible (e.g. curative liver resection for metastatic colorectal cancer). * patients with double primaries undergoing planned curative operation for both are eligible (e.g. synchronous colon cancers undergoing colectomy to treat both). * patients must be able to speak and complete questionnaires in english. exclusion criteria: * patients undergoing emergent surgery are not eligible. * patients under active treatment such as chemotherapy, targeted therapy, immunotherapy, radiation treatment, etc. for second primary, are not eligible. * patients with second primary are not eligible. * patients with known metastatic disease who are undergoing palliative resection are not eligible. * patients with psychiatric illness or other mental impairment that would preclude their ability to give informed consent or to participate in the prehabilitation program are not eligible.
ptns versus sham efficacy in treatment of bps

Conditions: Interstitial Cystitis Bladder Pain Syndromes

Summary: this is a prospective, single center, double-blind, randomized, controlled trial comparing the efficacy of percutaneous tibial nerve stimulation to sham in the treatment of bladder pain syndrome/interstitial cystitis (bps/ic) through 12 weeks of therapy.

this is a pilot study to evaluate the efficacy of the systematic effects of posterior tibial nerve stimulation (ptns) treatment compared to an inactive sham intervention in female subjects with interstitial cystitis/bladder pain syndrome (ic/bps) in an intent-to-treat analysis. the primary outcome measure will be the patient global impression of improvement (pgi-i) a single item questionnaire assessing overall impression of improvement over time at the initial 12 weeks endpoint. it is hypothesized that subjects randomized to the ptns arm will demonstrate a greater improvement in both pain and quality of life scores, when compared with subjects who are randomized to the sham arm.

Eligibility criteria:
inclusion criteria: * women ≥18 years old with visual analog scale \> 5 * cessation of all analgesics or other medication for pain for at least 2 weeks prior to the ptns intervention * discontinuation of any other electrical stimulation methods for 3 months prior to ptns intervention. * capable of giving informed consent * ambulatory * capable and willing to follow all study-relation procedures exclusion criteria: * patients pregnant or planning to become pregnant during the study duration * botox use in pelvic floor muscles within the last year * current urinary or vaginal infections * current use of interstim device * history of a cardiac pacemaker * diagnosis of neuropathy

Keywords: posterior tibial nerve stimulation, bladder
bicuspid echocardiac study team（best）

Conditions: Bicuspid Aortic Valve Disease

Summary: the chinese bicuspid aortic valve (bav) ultrasound imaging cohort study is a chinese bav ultrasound imaging cohort study. at present, a retrospective study cohort involving more than 30 hospitals has been established. the prospective multi-center study of bav is expected to include and follow up 200 outpatients and inpatients with bav. the clinical, ultrasound imaging and treatment parameters of the patients are collected and the patients are followed up for 2 years. to analyze the prognostic characteristics of bav patients and establish a chinese bav database. the primary endpoint was all-cause death, and the secondary endpoints were heart failure, angina, severe aortic stenosis, severe aortic insufficiency, ascending aortic diameter ≥50mm, and surgery (surgical and interventional). according to the different pathological types of aortic valve in different types of bav, ultrasound imaging was used to evaluate the different forms of valvular leaflet lesions and prognosis. finally, it provides a basis for the prognosis, treatment method, treatment timing and treatment plan selection of bav patients, and lays a foundation for the mechanism study of bav arterial lesions and the establishment of risk model for the prognosis of bav patients.


Eligibility criteria:
inclusion criteria: * ultrasound or other imaging tests to diagnose patients with bav exclusion criteria: * patients with tav or/and have significant aortic valve calcification * those deemed unsuitable for enrollment by clinicians (e.g., end-stage patients, mentally ill patients, non-cooperating patients, etc.) * those who do not agree to be included
mpv and nlr as predictors of sbp diagnosis

Conditions: Spontaneous Bacterial Peritonitis

Summary: the aim of the study is to investigate the clinical utility of mean platelet volume (mpv) and neutrophil to lymphocyte ratio (nlr) as diagnostic markers for spontaneous bacterial peritonitis (sbp).


Eligibility criteria:
inclusion criteria: * decompensated liver cirrhosis ascetic patients. exclusion criteria: * immunocompromised patients. * patients who had received antibiotics before hospital admission. * patients on anticoagulant medications, nsaids, or oral contraceptive drugs. * patients with heart failure, diabetes mellitus, hypertension, hyperlipidemia, peripheral vascular disease, hematological disorders, and neoplastic disorders and patients with clinically overt hypothyroidism or hyperthyroidism or with clinically and laboratory-evident autoimmune diseases.

Keywords: spontaneous bacterial peritonitis mean platelet volume neutrophil to lymphocyte ratio
study on immunization schedule of beijing tiantan biological's measles-mumps-rubella(mmr) vaccine

Conditions: Measles; Mumps; Rubella; Adverse Event Following Immunisation

Summary: this study will evaluate the immunogenicity and safety of beijing tiantan's mmr vaccine in subjects 18 months of age and older. the mmr vaccine may be administered as a second dose to 4-6 year-old persons with one dose immunization with mmr vaccine or as a first dose to 18 month-old subjects with one dose immunization with measles-rubella(mr).

this study will evaluate the immunogenicity and safety of beijing tiantan's mmr vaccine in subjects 18 months of age and older. the mmr vaccine may be administered as a second dose to 4-6 year-old persons with one dose immunization with mmr vaccine or as a first dose to 18 month-old subjects with one dose immunization with mr. immune efficacy and safety will be compared among different immunization schedules,including inoculation doses,enhanced immunity age,vaccination interval time. antibody persistence of 1 dose of mmr vaccine will be evaluated in this study.

Eligibility criteria:
inclusion criteria: * healthy children; 150 subjects 18 months old; 150 subjects 4 years old;300 subjects 5 years old; 150 subjects 6 years old; their guardians signed informed consent; * undiagnosed as measles, mumps and rubella; * in good health as determined by the outcome of medical history, physical examination and clinical judgment; suitable to mmr immunization; * guardians would comply with the requirements of the protocol; * immunized with mr or measles vaccine(mv) at 8 months old;immunized with mmr at 18 months old(not applicable to subjects 18 months old); unvaccinated by biological products within one month; * axillary temperature ≤37℃; * the local household population or permanent population; exclusion criteria: * history of allergic disease or reactions likely to be exacerbated by any component of the vaccine(any previous vaccination history of allergies and egg allergy history); * current confirmed as acute disease, severe chronic diseases or acute development of chronic diseases; * participating in another clinical trial at the same time;
super heroes: searching how the extract rebaudioside occludes excess steatosis

Conditions: Non-Alcoholic Fatty Liver Disease

Summary: in order to determine whether rebaudioside consumption can be used as a treatment for adolescents with non-alcoholic fatty liver disease (nafld) by demonstrating a decrease in alanine aminotransferase (alt) levels participants will be randomized to receive one of three 8-week liquid diet interventions: 1. standard of care 2. water delivery 3. water with rebaudioside (stevia natural sweetener)

rationale: current treatment strategies for nonalcoholic fatty liver disease, nafld, have focused on lifestyle management through a combination of diet and exercise but there are no recommendations for dietary changes that have been proven superior to others. preliminary data showing an improvement in liver enzymes and fibrosis in mice has demonstrated a novel use of rebaudioside, the non-caloric sweetener (ncs) stevia leaf's extract, potentially identifying this ncs as a therapeutic intervention where currently there are no targeted treatments. intervention: all participants will receive standard of care for diet and nutrition. additionally, participants will be randomized to one of four 8-week liquid diet interventions: 1. standard of care 2. water delivery 3. water with rebaudioside (stevia natural sweetener) objectives and purpose: to determine whether rebaudioside consumption can be used as a treatment for adolescents with nafld by demonstrating a decrease in alt levels.

Eligibility criteria:
inclusion criteria: * age: 10-18 years * alt \> 45 iu/l (twice the normal amount) * bmi \>85% * fat \>5% and kpa\> 2.7 exclusion criteria: * physician diagnosis of a major medical illness including, but not limited to, chronic liver disease, immunodeficiency disorder, hypothalamic obesity, or a genetic cause of obesity. * familial hyperlipidemia * positive hepatitis lab * antibiotics within 1 month of beginning the study * physical, mental, or cognitive issues preventing participation * pregnancy * smoking or drinking
effects of projected peripheral defocus on ocular biometrics

Conditions: Myopia

Summary: acucela inc. intends to develop a medical device to significantly halt or reverse myopic progression, which is a significant public health concern across the world, especially in asian demographics. acucela is working towards a spectacle-like device (especs), which will have a clear zone for unimpeded central visual tasks and a periphery that provides defocus in order to alter retinal physiology leading to myopia regulation. this study will establish the changes seen during a proof-of-concept that projected defocus in the periphery will stimulate physiological changes similar to those in the literature.


Eligibility criteria:
inclusion criteria: * spherical equivalent +2.00 to -4.00 diopters * refractive cylinder ≤ 0.75 diopters * visual acuity 20/20 -3 or better exclusion criteria: * pregnant or lactating * active ocular infection * history of dry eye, strabismus, or amblyopia * previous or planned ocular surgery * use of medication known to affect vision or accommodation
sexuality in transmen during hormone and operative treatment

Conditions: Gender Dysphoria; Gender Identity Disorder; Transsexualism; Body Image; Sexuality

Summary: with this analysis the investigators aim at discovering a difference in sexuality between transmen, cissexual women and cissexual men. a potential impact of body satisfaction will also be explored. furthermore the investigators want to assess the gender dysphoria in transmen.

the aim of the study is to investigate transmen's sexuality and body satisfaction during hormonal and surgical reassignment. furthermore sexual orientation, sexual behavior and gender dysphoria will be assessed. therefore an online survey with five measurements throughout the gender reassignment treatment is conducted. as a matter of routine, postoperative complications will be recorded retrospectively. to compare transmen's data with cisgender women and men we will be using data of the questionnaire's validation studies. the following questionnaires are used: sexuality: multidimensionaler fragebogen zur sexualität (brenk-franz \& strauß, 2011). sexual orientation: fragebogen zur sexualgeschichte und zum sexuellen verhalten (brenk, 2005) gender dysphoria: utrecht gender dysphoria scale (cohen-kettenis \& van goozen, 1997) body image: fragebogen zum körperbild (clement \& löwe, 1996) sociodemographic questionnaire: age, education, work, living situation, relationship status, gender reassignment treatment so far, coming out case report form t0: baseline measurement (patient is at the start of the hormonal treatment or has already startet but has not undergone any gender reassignment surgery) t1: within 2 weeks before the mastectomy t2: 6 months (+/- 2 weeks) after mastectomy t3: 6 months (+/- 2 weeks) after colpectomy t4: 6 months (+/- 2 weeks) after the last gender reassignment surgery

Eligibility criteria:
inclusion criteria: * transsexualism (female to male) approved by a psychologist's oder psychiatrist's report * good german skills * fully competent * good computer skills exclusion criteria: * insufficient german * patient rejects the participation

Keywords: transmen sexuality sexual behavior body image trassexualism
perioperative music listening on anxiety, pain, analgesia use and patient satisfaction

Conditions: Music; Pain; Anxiety; Patient Satisfaction; Analgesia

Summary: the use of music to relieve pain has been studied in many forms of medicines and has been proven to reduce anxiety, pain and analgesic use in the perioperative setting. however, music listening as an inexpensive and duplicable method has not been investigated and implemented in the local context. the investigators hereby propose a prospective study to recruit patients undergoing surgery to evaluate the effectiveness of music in pain relief and post-operative recovery; as well as the implementation and operational readiness of music listening.

some tissue injury is often unavoidable during surgery, which leads to unavoidable pain and anxiety during the perioperative and post-operative period. acute post-operative pain and anxiety have been managed via pharmacological interventions. however, non-pharmacological interventions have also been shown to be safe and cost-effective, improve the overall patient experience, and improve outcomes across a variety of surgical settings. music has been shown to decrease perioperative pain and modulate the inflammatory response. additionally, anxiety scores and pain scores have shown statistically significant reductions in the perioperative period, when music therapy was available. currently only few studies investigate its effects during perioperative period especially in local setting. thus, the investigators will investigate the feasibility and practicability of deploying music listening in kkh pain management and further determine the nature of the music (duration, genre) by fitting the local context in order to improve the patient outcome in perioperative settings. phase 1: a total of 300 patients will be offered to select from pre-determined lists of music of different genres or patient choice, before and after surgery. hospital anxiety and depression scale (hads) score, pain scores, analgesia usage, patient satisfaction, and quality of life measurement will be collected. analysis of the type of music, duration of music listening, and the genre chosen will be analysed. phase 2: a hundred and ten women undergoing caesarean delivery at kk women's and children's hospital (kkh) in 1:1 allocation ratio of experimental (music listening) and control (no music listening) groups. pain and psychological assessments and demographic data collection will be conducted before surgery, and those allocated to experimental group will be asked to use music listening before, during and after surgery.

Eligibility criteria:
inclusion criteria: * healthy participants who are american society of anesthesiologists (asa) 1 and 2 (with well-controlled medical problems); * undergo day surgery, same-day-admission gynecologic surgery or cesarean section; * no hearing impairment. exclusion criteria: * patients with significant respiratory disease and obstructive sleep apnea; * patients who are unable to read and understand the hospital anxiety questionnaire.
a study of hcc high risk group using two surveillance tools

Conditions: HCC

Summary: the purpose of this study is to compare sensitivity for hepatocellular carcinoma (hcc) of bi-annual ultrasonography and low dose computed tomography (ldct) in patients at high risk of hcc.

patients at high risk of hcc are recommended to undergo biannual surveillance using ultrasound. in this study, ldct is performed in addition to biannual ultrasound surveillance in eligible patients to compare their sensitivity for hcc. standard of reference would be follow-up imaging and/or gadoxetic acid-enhanced liver mri.

Eligibility criteria:
inclusion criteria: all conditions have to be satisfied to be enrolled. * \> 20 years * high risk group of hcc according to aasld guideline * risk index \> = 2.33 * currently on regular biannual surveillance using ultrasonography * sign informed consent exclusion criteria: patients with any of following condition cannot be enrolled. * previously diagnosed with hcc * any contraindication of contrast enhanced ct including allergic reaction to iodine * history of other malignancy

Keywords: surveillance ultrasonography computed tomography
transitions of care for stroke patients

Conditions: Stroke; Ischemic Stroke; Intracerebral Hemorrhage

Summary: for stroke patients, early initiation of therapy typically yields the best functional outcomes. rehabilitation of stroke patients immediately after hospitalization minimizes deleterious effects of immobility and facilitates restoration of function. the investigators are testing if coordinated efforts between the medical and rehabilitation disciplines may improve stroke patient's functional recovery and subsequent follow-ups after discharge.

stroke is the fifth leading cause of mortality, claiming the lives of 133,000 individuals in the united states annually. approximately one-quarter of the 795,000 annual strokes are recurrent. it is estimated that up to 80% of all strokes can be prevented. forty percent of stroke survivors sustain moderate functional impairments and 15% to 30% sustain severe disability. approximately 25% of adult stroke patients are readmitted to the hospital within six to twelve months of their preliminary stroke. identifying and implementing effective medical and rehabilitation interventions is critical in providing care to stroke patients. the goal is to provide optimal, cost-effective care that: 1) prevents secondary medical complications, readmissions, and recurrent disease, and 2) maximizes patient function physically, cognitively, and socially. jfk johnson rehabilitation institute (jri) proposes a collaborative study with robert wood johnson university hospital (rwjuh) that addresses this issue while proving beneficial to stroke patients at both institutions. streamlining the physiatry consult process will improve access to rehabilitation medicine specialty care for acute patients at rwjuh and help facilitate the transfer of stroke patients to the next most appropriate level of care.

Eligibility criteria:
inclusion criteria: * stroke patients hospitalized within robert wood johnson university hospital system for ischemic stroke or intracerebral hemorrhage. exclusion criteria: * those not in the robert wood johnson university hospital system. * those with a subarachnoid hemorrhage or transient ischemic attack (\< 24 hours).

Keywords: stroke physiatry rehabilitation pm&r consultation transient ischemic attack intracerebral hemorrhage ischemic stroke
correlation between body mass index and progressive grafted bone in cleft patients

Conditions: Cleft Lip and Palate; Bone Graft; Complications

Summary: the cleft patients received alveolar bone graft(abg) for alveolar defect. body mass index (bmi) was measured for each patients when receiving abg. bone mineral density was measured by cone-beam ct at two time-points: post-abg six months, and post-abg two years. the study was to analyze the correlation between bmi and post-operative bone mineral density.

although childhood obesity is a growing issue, the association between bmi and the progressive bone mineral density (bmd) in grafted tissue after secondar alveolar grafting (abg) remains little reviewed. this study compared the correlation between bmi and the progressive bmd after abg procedure. thirty-nine patients with unilateral or bilateral clefts were enrolled. abg was performed at mixed-dentition age. patient were classified into underweight, normal weight, and overweight or obese based on age- and sex-adjusted bmi. bmd was expressed in hounsfield unit (hu) on cone-beam computed tomography (cbct), which was obtained at 6 months (t1) and 2 years (t2) postoperatively. calibrated bmd (hugrafted tissue/hupogonion¬, bmdc) was used for further analysis.

Eligibility criteria:
inclusion criteria: * nonsyndromic unilateral or bilateral cleft lip and alveolus with or without palate patients * received secondary abg at chang gung craniofacial center * received team managements based on our current treatment protocol for cleft lip and palate exclusion criteria: * syndromic cleft * patients with failed grafted tissue

Keywords: alveolar bone grafting body mass index bone mineral density cone beam computed tomography