Kornimate/medical-research-clean huggingface dataset:
light therapy for depression during pregnancy

Conditions: Major Depressive Disorder; Pregnancy

Summary: the purpose of this study is to determine whether morning bright light therapy is an effective treatment for major depression during pregnancy compared with low-intensity placebo light therapy, when administered 60 minutes daily for 5 weeks.

affective disorder during pregnancy is a common and severe condition, associated with a higher risk for prenatal complications, preterm delivery, a higher rate of surgical birth and vaginal operative delivery. depressed pregnant women are at risk for inadequate nutrition, poor weight gain, increased use of nicotine, drugs and alcohol, and failure to obtain adequate prenatal care, as well as poor mother-child attachment. their infants have a higher risk for low birth weight, a higher rate of admission to neonatal intensive care, and cognitive, emotional and behavioural disturbances.treatment of antepartum depression requires careful judgement to minimise risk to the foetus. pharmacological treatment is an option, but all antidepressants cross the placenta, and both practitioners and patients are concerned about possible teratogenicity, pre- and perinatal adverse effects for the infant, as well as negative effects on long-term development. thus, psychiatric medication use for depression in pregnancy may also pose an excess risk of preterm delivery and withdrawal symptoms in the newborn. treatment of depression during pregnancy that is efficacious, reliable, safe, and with minor side effects is an urgent unmet clinical need. light therapy may provide this somatic, non-pharmaceutical alternative. it is well established as the treatment of choice for seasonal affective disorder (sad), and there is a growing data base for response in nonseasonal major depression. two promising pilot studies led to the present randomised, double-blind, placebo-controlled trial of 5 weeks daily morning bright light therapy (1h, 7000 lux white) compared with low-intensity placebo light therapy (1h, 70 lux red).

Eligibility criteria:
inclusion criteria: * german-speaking * medically healthy with normal ocular function * pregnancy 4 through 32 weeks gestation based on first trimester ultrasound * dsm-iv diagnosis of major depressive disorder * sigh-ads \[structured interview guide for the hamilton depression rating scale (hamd) with atypical depression supplement\] score of \>20 * able to provide informed consent * preferably untreated; exception when on antidepressant for more than 3 months without any improvement, keeping medication constant during the study exclusion criteria: * dsm-iv diagnoses of bipolar 1 or 2 disorder or any psychotic episode * substance abuse within the last 6 months * primary anxiety disorder * recent history of suicide attempt (6 months) * delayed sleep phase disorder or hypersomnia with habitual sleep onset later than 1 a.m. or wakening later than 9 a.m. * obstetrical care or medications for medical disorders which might confound treatment results * fetal malformations and intrauterine fetal death

Keywords: light therapy antepartum depression controlled trial
effects of hands-on-healing vs. touch for fatigued breast cancer survivors

Conditions: Breast Cancer

Summary: this randomized controlled trial examines the efficacy of hands-on-healing for fatigue and immune function in breast cancer survivors. participants may be randomized to one of three groups: hands-on-healing, touch alone, or a control group.

please see our website at http://healing.ucsd.edu for detailed information on the study.

Eligibility criteria:
inclusion criteria: * premenopausal and postmenopausal women between the ages of 18 to 70 years. * ability to give informed consent. * breast cancer survivors who have undergone surgery, including lumpectomy and simple or total mastectomy, followed by chemotherapy or a combination of chemo- and radio-therapy. we have elected to study survivors instead of patients actively undergoing treatment to alleviate subject burden and risk during this protocol. * stage i to iii breast cancer survivors. * breast cancer survivors who have finished their chemotherapy and/or radiotherapy at least one month prior to 60 months prior. * breast cancer survivors with above-normative levels of fatigue. exclusion criteria: * breast cancer patients who are currently receiving or who are scheduled to receive radiation or chemotherapy during the course of this intervention study. * patients with current major depression, current or history of prior bipolar illness, currently on psychotropic medications. * patients with other diseases that are known to induce fatigue (e.g., thyroid disorder; sleep disorders). * patients with other inflammatory diseases that affect cytokine levels. * patients with a history of other cancers, and stage iv breast cancer. * patients undergoing current chemotherapy and/or radiotherapy. * men with breast cancer. * substance abuse/dependence. * continued use of another biofield-based intervention (e.g., reiki, qi-gong, healing touch, therapeutic touch, johrei).

Keywords: cancer fatigue breast cancer healing energy healing complementary alternative immune cytokine hormone cortisol placebo mock healing
comparison of quadratus lumborum block types

Conditions: Pain; Opioid Use; Lumbar Disc Herniation

Summary: this study will compare the quality of analgesia and reduction of opioid use, between standard of care and two groups of local anesthetic blocks in different location in the quadratus lumborum plane, for postoperative pain control after lumbar spinal fusion and if it reduces opioid consumption.

this study is a pilot study as part of planning for a larger randomized controlled trial. the study plans to enroll a total of 30 patients, with 10 patients randomly assigned in each group of the study. group i will receive the standard of care multimodal pharmacological management. group ii will receive standard of care multimodal pharmacological management plus the quadratus lumborum ii local anesthetic block. group iii will receive standard of care multimodal pharmacological management plus the quadratus lumborum iii local anesthetic block. measurements of opioid use, pain, and side effects will be recorded for each patient.

Eligibility criteria:
inclusion criteria: * adult patients undergoing lumbar spinal fusion surgery. * patients from 40-80 years. exclusion criteria: * recent drug abuse * history of illicit drug use * chronic pain patients not related to the back lesions. * opioid tolerant patients. * patients with any lower extremity weaknesses or deficits. * patients with american society of anesthesiologists (asa) classification more than 3. * coagulopathy. * infection near or in the area of the block. * pregnant patients. * uncooperative patients who refuse care which directly effects research participation or clinical care. * if the surgeon reports performing non-typical fusion. * the presence of intraoperative complications like nerve injury or abnormal results of neuromonitoring and extensive dissection. * vulnerable populations (prisoner, mental impairment / dementia, pregnant, etc.) * subjects on chronic buprenorphine therapy (either for opioid replacement or pain control)

Keywords: lumbar spine nerve block opioid use pain
irinotecan, gemcitabine, chemotherapy for biliary tract cancer

Conditions: Biliary Tract Cancer

Summary: the study hypothesis is that chemotherapy of irinotecan and gemcitabine will improve local control of cancer and prolong survival in patients with inoperable biliary tract cancer.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed inoperable biliary tract cancer * age: 18 \~75 years old * performance status: ecog 0-2 * hematopoietic: * granulocyte count at least 1,500/mm3 * platelet count at least 100,000/mm3 * hepatic: * bilirubin no greater than 2 fold the upper normal limit * ast/alt : no greater than 3 fold the upper normal limit * renal: * creatinine - no greater than 1.5 mg/dl * not pregnant * no other serious medical or psychiatric illness that would preclude giving informed consent or limit * no prior chemotherapy within 6 months * no other concurrent anticancer radiotherapy within 6 months

Keywords: toxicity
pir of quadratus lumborum with and without gluteus maximus activation in innominate upslip suprapubic dysfunction

Conditions: Innominate Upslip Suprapubic Dysfunction

Summary: the innominate up slip dysfunction is the most common in athletes and non-athletes, who present with low back pain and sacroiliac dysfunction. the main muscular structure that forms the force closure of the joint involves the bicep femoris and gluteus maximus that are involved in the stability of the of the pelvis through immense attachments through the sacro-tuberous ligament. the objective of this study is to determine the effectiveness of post isometric relaxation (pir) of quadratus lumborum with and without gluteus maximus activation on pain, disability and pelvic tilt angle in patients with innominate upslip suprapubic dysfunction. the study will be a randomized controlled trial involving 34 patients both males and females aged 20 to 40 years with history of unilateral pelvic pain not radiating to l5 or above, positive finding of sitting flexion test, standing flexion tests, stork test and positive active straight leg raise test will be randomly recruited by consecutive sampling technique. the subjects having ankylosing spondylitis, lumbar radiculopathy, spinal pathologies, or any lumbar fracture will be excluded. all the patients in the study will be randomly assigned into two groups where group a will be given muscle energy technique of quadratus lumborum along with gluteus maximus activation and group b will be a control group treated with muscle energy technique only. both groups will be given buttock squeezing and drawing in maneuver as common treatment along with muscle energy technique. each session will be repeated for 20 minutes thrice a week. the treatment duration will be 4 weeks. outcomes will be measured at the first day and then at the end of the 4th week by numeric pain rating scale, modified oswestry disability index and ihandy inclinometer application. .


Eligibility criteria:
inclusion criteria: 1. patients aged 20 to 40 years 2. both males \& females 3. history of unilateral pelvic pain not radiating to l5 or above 4. positive finding of sitting flexion test, standing flexion tests, stork test. 5. positive active straight leg raise test exclusion criteria: 1. subjects diagnosed with ankylosing spondylitis. 2. lumbar radiculopathy 3. spinal pathologies including spondylosis and spondylolisthesis. 4. subjects immediately post pregnancy. 5. disc herniation 6. lumbar fractures or spinal surgeries

Keywords: sacroiliac joint suprapubic dysfunction muscle pain innominate upslip pelvis
a study of the safety and efficacy of regn475(sar164877) in patients with osteoarthritis of the knee

Conditions: Osteoarthritis of the Knee

Summary: this is a double-blind, prospective, randomized study in which patients will be randomized to 1 of 4 treatment arms (3 active and 1 placebo). each patient will receive two doses of active medication or placebo, with study drug administered intravenously (iv). the primary goal of the study is to assess the safety and tolerability of repeat administrations of regn475 compared to placebo in patients with osteoarthritis (oa) of the knee.


Eligibility criteria:
inclusion criteria: 1. men and women ≥ 40 and ≤ 75 years of age. 2. diagnosis of oa of the knee according to american college of rheumatology (acr) criteria, and experiencing moderate to severe pain in the index knee for at least 3 months prior to the screening visit. 3. kellgren-lawrence grade 2-3 radiographic severity of the index knee at or within 6 months prior to screening. exclusion criteria: 1. significant concomitant illness including, but not limited to, cardiac, renal, neurological, endocrinological, metabolic or lymphatic disease that would adversely affect the patient's participation in the study. 2. patients with joint replacement in the affected knee. 3. patients with peripheral neuropathy due to any reason.
families in recovery from stroke trial (f.i.r.s.t.)

Conditions: Stroke

Summary: the purpose of this trial is to assess the effects of a psychosocial intervention on functional recovery after stroke.

prior research shows that, after a stroke, emotional support from friends and family is very important in recovery from stroke. this study was designed to test whether a program of family sessions would lead to a faster recovery for stroke patients and lower stress for their families. the sessions were designed to mobilize the family and close friends of a stroke patient and help them to provide effective support to the patient. the aim of the study was to help patients who have recently had a stroke to achieve greater functional ability. participants were randomly assigned to either the standard care or the treatment group. those in the treatment group received standard care plus a maximum of 16 home-based sessions, or family meetings, with a specially-trained clinician. (the majority of participants received 14 or 15 sessions.) the sessions included stroke education, information about services and community resources, assistance with problem solving to aid in gaining independence, help with coping, and emotional support. the study is no longer enrolling patients and the study data has been collected. the data is now being analyzed.

Eligibility criteria:
inclusion: * patients with ischemic stroke or non-traumatic intracerebral hemorrhage, with residual deficit origin; * age 45 or older * stroke severity (3-8 on the nih stroke severity scale); and * able to participate in the intervention (due to, for example, ability to communicate or level of social connectedness). exclusion: * patients living outside the greater boston area; * admitted from a nursing home; * terminally ill; * severely aphasic; * significantly cognitively impaired; * unable to speak english; and * under 45 years of age.

Keywords: stroke recovery
eisenmenger quality enhancement research initiative

Conditions: Pulmonary Arterial Hypertension

Summary: eisenmenger quality enhancement research initiative (queri) is a multi-center, observational, us-based longitudinal program, with enrollment of consecutive eisenmenger patients who meet enrollment. patient data will be collected prospectively for three years. individual physician feedback will be provided on data collected with the purpose of improving the management of patients - quality enhancement research initiative (queri) process.

approximately 200 male and female adult patients with a history of eisenmenger will be recruited from approximately 50 cardiology practices over a period of 18 months and will be followed up every six months for the period of three years. consecutive patients in each practice meeting inclusion and exclusion criteria should be considered for the study. participating sites will be asked to maintain a screening log to identify which inclusion or exclusion criteria was not met thus excluding them from the study.

Eligibility criteria:
inclusion criteria: * male and female patients * diagnosis of eisenmenger syndrome based on right heart catheterization data * right to left intra-cardiac shunting * pah * need for comprehensive management according to guidelines and peer-reviewed evidence * ability and desire to execute the consent for follow up exclusion criteria: * poor mental function, drug, or substance (e.g.,alcohol) abuse, or unstable psychiatric illness, which, in the opinion of the investigator, may interfere with optimal participation in the study * prior inclusion in this program

Keywords: eisenmenger
somatostatin, octreotide, pentoxyfilline in the prevention of post-ercp pancreatitis and molecular markers

Conditions: Post-ERCP Acute Pancreatitis

Summary: octreotide, somatostatin and pentoxyfilline commercially available drugs that are used in various clinical situations. they are safe and known for years. octreotide and somatostatin have been used in many studies for the prophylaxis and treatment of pancreatitis and post-ercp pancreatitis, while pentoxyfilline has shown effect on patients with alcoholic hepatitis, obstructive vasculitis etc. the aim of the study is to evaluate the efficacy of any of those treatments for the prophylaxis and treatment of post-ercp pancreatitis. in addition some molecular markers of acute and chronic inflammation will be measured before and after the endoscopic procedures according to the study protocol.


Eligibility criteria:
inclusion criteria: * patients undergoing endoscopic retrograde cholangiopancreatography exclusion criteria: * children, pregnant or breastfeeding women * patients with coagulation disorders * inability to access the papilla of vater due to technical difficulties (previous surgery, malignant obstruction)

Keywords: post-ercp pancreatitis prophylaxis prognosis natural course molecular markers
effects of neuro-dynamic mobilization techniques on upper limb functions in pronator teres syndrome

Conditions: Pronator Teres Syndrome

Summary: the study aimed to determine the effects of neuro-dynamic techniques on upper limb motor and sensory functions and to compare the effects of slider versus tensioner neuro-dynamic techniques on upper limb motor and sensory functions in pronator teres syndrome.

the study aimed to determine the effects of neuro-dynamic techniques on upper limb motor and sensory functions and to compare the effects of slider versus tensioner neuro-dynamic techniques on upper limb motor and sensory functions in pronator teres syndrome. pronator teres syndrome is a rare condition and easily overlooked and mistaken for the more prevalent carpal tunnel syndrome. the median nerve may also be squeezed between the heads of the pronator teres muscle in addition to the carpal tunnel. patients report pain, numbness, or paresthesia over the lateral 3.5-digit area and anterior forearm, which worsens with forced pronation. this condition is most common in the dominant hand or sometimes can be associated with advanced forearm muscle.in our routine clinical practice, the neuro-dynamic techniques is not that common in neurological physical therapy practice so the effects of neuro -dynamics with conventional therapy needs to be evaluated for better outcomes in upper limb functions.

Eligibility criteria:
inclusion criteria: * diagnosed with pronator teres syndrome * at least 6 working hours/ day * positive tinel's sign at pronator area (hoffman's sign) * positive pronator teres syndrome test exclusion criteria: * any previous history of metabolic disease, liver disease/ diabetes * history of previous injuries to the cervical spine including radiculopathies and myelopathies as well as spinal stenosis and/or spinal disc herniation

Keywords: upper limb functions neurodynamics pronator teres syndrome task oriented training
effects of kimchi supplementation on gut microbiota, dna methylation and serum proteomes

Conditions: Obesity

Summary: participants will ask to answer questionnaire related to general characteristic, lifestyle, dietary pattern and undergo physical examination and measurement of body composition. the subjects will be divided into 2 groups: healthy control and intervention. the intervention group was divided into 3 subgroups: the fermented vegetable (kimchi) group, the kimchi supplemented with polyphenol (vitexin) group, or the kimchi supplemented with probiotic (lactobacillus rhamnosus) group. the intervention group will be instructed to consume 1 pack of kimchi per day (50 g/pack) with lunch for 2 months.

the subjects will be divided into 2 groups: healthy control and intervention. the intervention group was divided into 3 subgroups: the fermented vegetable (kimchi) group, the kimchi supplemented with polyphenol (vitexin) group, or the kimchi supplemented with probiotic (lactobacillus rhamnosus) group. the intervention group will be instructed to consume 1 pack of kimchi per day (50 g/pack) with lunch for 2 months. during the study, participants will be strongly encouraged to avoid consuming prebiotics or probiotic supplements, as well as foods such as yogurt, sour milk, fermented vegetables, and fermented fruits, especially 2 weeks before the blood and fecal examination. compliance will be assessed by monitoring product side effects through follow-up phone calls every week to check on participants' symptoms and assessing the number of sachets or packs they actually consume.

Eligibility criteria:
inclusion criteria: for the intervention group * age 35-50 years, bmi of ≥23 kg/m2, presence or absence of metabolic syndrome (not treated by medication) according to the national cholesterol education program (ncep atpiii 2007), in collaboration with the international diabetes federation (idf) and the world health organization (who), metabolic syndrome exclusion criteria:for the intervention group * participants declined or withdrew, history of taking antibiotics in the 12 weeks prior to the project, history of using prebiotics or probiotic supplements on a regular basis, history of eating foods in these groups regularly, including yogurt, sour milk, fermented vegetables, and fermented fruits, history of taking drugs or weight loss products in the previous 6 months, history of diarrhea or constipation regularly, history of cure for ulcerative colitis, history of underlying disease that requires continuous medication, history of taking laxatives regularly, history of severe gastrointestinal disease, and history of illnesses such as thyroid disease, cancer, autoimmune diseases, kidney disease and hypertension etc.

Keywords: dna methylation proteomic microbiota
radiological investigation of bile duct obstruction

Conditions: Gallstone Disease

Summary: patients with gallstone disease should be checked whether a common bile duct (cbd) stone could be present. in case of a certain suspicion for cbd stones further investigations should be performed. this can either be done by magnetic resonance cholangio-pancreaticography (mrcp) or by intraoperative cholangiography. the study investigates which pathway would be favorable in regard of an early hospital demission.

patients with gallstone disease and suspected bile duct obstruction can be investigated either with a magnetic resonance cholangio-pancreaticography (mrcp) prior to gallbladder removal or with an intraoperative cholangiography during cholecystectomy. when detecting an common bile duct (cbd) stone in mrcp, normally endoscopic removal is performed before an operation. when the cbd stone is detected during gallbladder removal instead, endoscopic retrograde cannulation of the pancreatic duct (ercp) will follow after the operation. investigators hypothesize that direct operation shortens the length of hospital stay. therefore investigators randomize patients with elevated bilirubin, elevated liver enzymes (two of the following: aspartate transaminase (asat), alanine aminotransferase (alat), gamma-glutamyltransferase (ggt) or ap), suspected cbd stones in ultrasound or dilated common bile ducts either in mrcp first or operation first pathway. all data (patient admission to discharge, ...) will be entered in an online database

Eligibility criteria:
inclusion criteria: * patients presenting as regular admission or at the emergency department (ed) with cholecystolithiasis and suspected cbd stones. the indication for cbd investigation requires one of the following features: i. elevated bilirubin ii. asat/alat or ggt or ap above the normal range (two of them) iii. choledocholithiasis in ultrasound iv. dilated bile ducts in ultrasound * written informed consent exclusion criteria: * age under 18 years * patients with biliary pancreatitis (due to the fact that conservative treatment is initiated before gallbladder removal and therefore leads to a prolonged hospital stay) * septic patients due to cholangitis * patients unable to consent * patients with medical conditions preventing surgery * pregnancy * radiologically proven cbd stone

Keywords: bile duct obstruction intraoperative cholangiography mrcp