Kornimate/medical-research-clean huggingface dataset:
copeptin changes after food intake

Conditions: Healthy Adults; Copeptin

Summary: the purpose of this study is to determine whether copeptin levels are affected by food intake.


Eligibility criteria:
inclusion criteria: * aged over 18 years exclusion criteria: * intake of any kind of medication (except birth control pill) * bmi \>30 kg/m2 * evidence of any acute illness * history of chronic illness * pregnancy * known galactosemia or maltose malabsorption * baseline glucose level \>5.5 mmol/l baseline sodium level \ 145 mmol/l

Keywords: copeptin eating glucose tolerance test mixed meal test physiological
a randomised efficacy study of combination antimalarials to treat uncomplicated malaria

Conditions: Malaria

Summary: the purpose of this study is to determine the efficacy of sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine alone in the treatment of uncomplicated malaria.

resistance of plasmodium falciparum to anti-malarial drugs is a serious impediment to the control of malaria. in order to facilitate formulation of effective regional drug policies and to provide a database for decision-making on the implementation of combination therapy (cat), it is essential that the in vivo response to cat be investigated. in the south east african combination anti-malarial therapy (seacat) evaluation, there is a comprehensive evaluation of the phased introduction of combination anti-malarial therapy in mozambique. as a component of this evaluation, in selected mozambique sites where intensity of malaria transmission is high, a direct parallel group comparison of monotherapy (sp) with cat (artesunate plus sp) will be conducted according to this protocol.

Eligibility criteria:
inclusion criteria: * male or female, older than 12 months. * weight \> 10 kg. * diagnoses of pure uncomplicated acute p. falciparum malaria parasitaemia of up to 500 000 asexual parasite/mcl blood with axillary temperature of greater than or equal to 37.5°c or history of fever (defined as within the previous 24 hours). * documented informed consent. * lives close enough to the study site for reliable follow up. exclusion criteria: * has received anti-malarial treatment in the past 7 days. * is infected with other malarial species (such subjects may be excluded retrospectively from the analysis). * severely ill (based on who criteria for severe malaria ) or if patient is considered, in the opinion of the investigator or designee, to have moderately severe malaria (e.g. prostrate, repeated vomiting, dehydrated) or other danger signs. * has received cotrimoxazole, trimethoprim, chloramphenicol, folate or tetracyclines (including doxycycline) in the past 7 days or is likely to require these during the study period. * history of g6pd deficiency. * is pregnant or breastfeeding. * has a history of allergy to any of the study drugs (including other sulphonamides e.g. cotrimoxazole, other artemisinin derivatives e.g. co-artemether). * serious underlying disease that in the opinion of the clinic team and/or principal investigator would make the patient unsuitable for the study in terms of their safety or study analysis.

Keywords: malaria efficacy pharmacokinetic gametocyte molecular markers sulfadoxine-pyrimethamine artesunate artemisinin
fluid immersion simulation (fis) system versus air fluidized bed (afb) system for pressure ulcers

Conditions: Pressure Ulcer

Summary: the primary objective is to compare the efficacy of the fis on closure rate to the afb after 2 weeks of operative debridement and closure.

secondary objectives: 1. compare the complication rate in each treatment group during the acute postoperative period (2 weeks). 2. comparisons of the inflammatory and bacterial microbiomes of pressure ulcers following surgical therapy. 3. comparisons of baseline patient characteristics and their relationship to both early and late pressure ulcer recurrence, and complication rates. 4. assessment of outcomes and complications associated with flap technique and surgeon guided descriptions of the operative closure. 5. compare the absolute costs associated with the fis system against afb system. 6. compare the acceptance of each system by subjects and nursing staff, including the parameter of patient comfort at 7 and 14 days postoperative. 7. assessing the incidence of complications and additional treatments needed following the two week study period.

Eligibility criteria:
inclusion criteria: 1. will be admitted as an inpatient 2. is ≥ 18 years of age and ≤ 85 years of age at time of consent 3. is able to provide his/her own informed consent 4. is deemed by the investigators to be reasonably compliant 5. has a pressure ulcer meeting criteria for stage iii or iv 6. has not participated in a clinical trial within the past 30 days 7. has a 30-day wound history available if the wound has been previously treated exclusion criteria: 1. has a life expectancy of \< 12 months 2. is not healthy enough to undergo surgery for any reason 3. has a history of radiation therapy 4. is, in the opinion of the investigator, noncompliant 5. has a history of \> 3 closures of pressure ulcers in the same site 6. has a history of a bleeding disorder 7. has severe fecal incontinence

Keywords: support flap pressure surface closure ulcer
effect of botulinum toxin type a on swallowing in patients with cervical dystonia

Conditions: Torticollis

Summary: the purpose of this study is to evaluate swallowing efficiency in patients with cervical dystonia following treatment with botulinum toxin type a.


Eligibility criteria:
inclusion criteria: * diagnosed with cervical dystonia * successfully completed allergan study medaff btx-0616 with 16 weeks since last botulinum toxin type a injection * in need of additional botulinum toxin type a injections exclusion criteria: * surgery or spinal cord stimulation for cervical dystonia * previous injections of phenol or alcohol for cervical dystonia
comparison of continuous esp versus tea after thoracotomy

Conditions: Postoperative Pain

Summary: this prospective, randomized, assessor-blinded study is designed to evaluate the postoperative analgesic efficacy of the ultrasound-guided continuous erector spinae plane (esp) block in patients undergoing thoracotomy. we hypothesize that us-guided esp block is not inferior to thoracic epidural analgesia in terms of postoperative pain control in these patients.

adult patients undergoing elective unilateral thoracotomy for lung cancer resection are randomly allocated to receive us-guided esp block (n=31) or thoracic epidural analgesia (n=31). both procedures are performed prior to surgery. each patient was assessed by a blinded investigator on postoperative day (pod) 1,2 and 3. the primary outcome is pain severity evaluated by a numeric rating scale (nrs) at pod1.

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo elective thoracotomy for lung cancer * european cooperative oncology group 0 or 1 * american society of anesthesiologists (asa) physical classification i-iii * willingness and ability to sign an informed consent document exclusion criteria: * patients with chronic postoperative pain after thoracic surgery * patients undergoing thoracotomy with chest wall resection * allergies to anesthetic or analgesic medications * patients with coagulopathy or who continue to take anticoagulants * preoperative liver or renal dysfunction * patients with chronic pain, chronic opioid, analgesic or antidepressant or anticonvulsant use * do not understand our study * medical or psychological disease that can affect the treatment response

Keywords: thoracotomy lung cancer interfascial plane block nerve block
correlation of social media usage with physical activity and academic performance in children

Conditions: Social Media Addiction

Summary: social media are internet-based applications that allow users to exchange messages or user-generated content for the purposes of social connection, entertainment, or education. whatsapp, skype, facebook, instagram, telegram, and twitter are a few of the most well-known and frequently used virtual social networks. in young children and school-age populations have concentrated on the correlation between watching television and playing video games and academic achievement, demonstrating a detrimental impact on physical health. children who watch television for more than two hours a day tend to perform worse academically and engage in less physical activity.

the study will be conducted as a non-probability convenience sampling with the objective of social media usage on physical activity and academic performance in young school-age individuals. patient age range from 10 to 16 years, both genders. sample size is 289 students of private and government schools. collaborate with schools within the selected age range and obtain permission for the study. the patients' assessment includes the use social media addiction scale, academic performance questionnaire, samu dis-fit battery. data will be analyzed by spss version 26. descriptive statistics will be checked by using frequency, percentage, mean and standard deviation of the variables. normality of the collected data will be checked by using spss version 26. if p value will be more that 0.05 will apply parametric test. if it is less than 0.05 will apply non parametric test. pearson correlation "r will be applied for parametric data and spearmon rao will be used for non-parametric data

Eligibility criteria:
inclusion criteria:• age of the participant will be 10 to 16 years.(3) * male and female both will be included.(25) * constantly using screen time with minimum 40 minutes per day.(5) * healthy and physical fit participant will be included. • regular and enrolled students of public and private schools exclusion criteria: children with disabilities that are limited in their ability to understand the instructions or the performance of the activities (cognitive impairment etc.) * students with any significant past medical history or surgical history will not be included in this study

Keywords: social media physical activity academic performance school
efficacy of pulsatile gnrh therapy on male patients with pituitary stalk interruption syndrome

Conditions: Hypogonadotropic Hypogonadism

Summary: to investigate the hormone response of hypothalamic-pituitary-gonad axis and spermatogenesis in male pituitary stalk interruption syndrome patients by pulsatile gnrh therapy.

to investigate the hormone response of hypothalamic-pituitary-gonad axis and spermatogenesis in male pituitary stalk interruption syndrome patients by pulsatile gnrh therapy. the hormonal response of the hypothalamic-pituitary-gonad axis was assessed after pulsatile gnrh replacement by measurement of serum t, lh and fsh. a standard seminal fluid analysis was performed in men who could produce an ejaculate.

Eligibility criteria:
inclusion criteria: * 18 years or over male patients; * absent or incomplete puberty development; * serum testosterone values below 3.47 nmol/l by low or normal serum lh and fsh concentrations. * at least two or more pituitary hormone deficiencies * brain mri showed absent and thin pituitary stalk, or pituitary hypoplasia and/or ectopic posterior pituitary. exclusion criteria: * cryptorchidism history * other causes of hypopituitarism or severe systemic disease

Keywords: pituitary stalk interruption syndrome pulsatile gnrh therapy hypogonadotropic hypogonadism hypopituitarism
the effect of using two different prosthetic feet in patients with unilateral transtibial amputation

Conditions: Amputation

Summary: background: prescribing optimal prosthetic feet to ensure successful rehabilitation is difficult since there are no generally established clinical guidelines based on objective data. aim: to investigate the effect of using non-articulated dynamic foot (non-articulating ankle, naa) and dynamic foot with hydraulic ankle (articulating hydraulic ankle, aha) on functional capacity, pain severity, satisfaction level and quality of life (qol) in high activity patients with unilateral transtibial amputation.

background: prescribing optimal prosthetic feet to ensure successful rehabilitation is difficult since there are no generally established clinical guidelines based on objective data. aim: to investigate the effect of using non-articulated dynamic foot (non-articulating ankle, naa) and dynamic foot with hydraulic ankle (articulating hydraulic ankle, aha) on functional capacity, pain severity, satisfaction level and quality of life (qol) in high activity patients with unilateral transtibial amputation. methods: forty-two patients with unilateral transtibial traumatic amputation will be participated in this cross-sectional study. functional capacity will be evaluated using the six-minute walking test (6mwt). the severity of residual limb pain, sound limb pain and low back pain will be evaluated with a 10-point visual analogue scale (vas). the socket system, prosthetic foot and overall prosthesis satisfaction will be evaluated with a 10-point vas. the qol of each patient will be assessed using the short form 36 (sf-36).

Eligibility criteria:
inclusion criteria: * aged 18-65 years * medicare functional classification level k4 (very active) * using the prosthesis for at least 6 months and at least 6 hrs a day * using active vacuum-assisted suspension system exclusion criteria: * bilateral amputation, * the presence of neurological, cardiovascular and pulmonary disease that could affect walking performance.

Keywords: transtibial amputation prosthetic foot functional capacity satisfaction quality of life
regend001 autologous basal layer stem cell transplantation for bronchiectasis: a translational application study

Conditions: Bronchiectasis Adult

Summary: this clinical trial aims to evaluate the safety and efficacy of regend001, an autologous basal layer stem cell transplantation therapy, in patients with chronic structural lung disease (bronchiectasis). the treatment involves harvesting bronchial basal layer stem cells from the patient, expanding them ex vivo, and reintroducing them via bronchoscopic infusion to repair damaged lung tissue.


Eligibility criteria:
inclusion criteria: 1. age 25-80 years. 2. confirmed diagnosis of bronchiectasis. 3. fev1 ≥35% predicted; dlco ≥30% and \<80% predicted. exclusion criteria: 1. pregnancy, lactation, or plans for pregnancy within 1 year. 2. active malignancy or history of malignancy. 3. positive serology for hiv, hbv, hcv, or syphilis.
spinal cord stimulation in chemotherapy induced neuropathy

Conditions: Chemotherapy-induced Peripheral Neuropathy

Summary: this is an observational based pilot study evaluating the use of spinal cord stimulators for the treatment of chemotherapy induced peripheral neuropathy will lead to an increase in quality of life and decrease in pain.

cancer treatment, for many patients, results in painful side effects. as evidence mounts demonstrating the risks associated with long term opioid therapy, non-opioid modalities need to be developed. spinal cord stimulators are implanted devices that modulate the pain signaling system in the spinal cord. this research hopes to determine if the use of a spinal cord stimulator in patients with chemotherapy induced peripheral neuropathy will lead to an increase in quality of life and decrease in pain.the primary endpoints will be the number of patients who undergo permanent implantation. the endpoints will measure pain with the brief pain inventory short form visual analog scale. the sleep quality will be measured using the pittsburgh sleep quality assessment.

Eligibility criteria:
inclusion criteria: • the patient has persistent, severe peripheral neuropathy secondary to chemotherapy exclusion criteria: • refusal to undergo a spinal cord stimulator procedure
capillary versus suction needle aspiration for endobronchial ultrasound (ebus) biopsies.

Conditions: Lung Cancer; Mediastinal Lymphadenopathy; Thoracic Cancer

Summary: endobronchial ultrasound (ebus)-guided transbronchial needle aspiration is a procedure used to obtain tissue samples (biopsies) of lymph nodes near the airways or of lung tumours growing in close proximity to the airways. briefly, an endoscope with an ultrasound probe which is inserted through the mouth and into the airways. once in the airways, the ultrasound allows for identification of the optimal biopsy site; a hollow biopsy needle is then inserted into the tissue under real-time ultrasound visualization and a sample is extracted. in the investigator's centre, the extracted sample is then immediately subjected to rapid on-site evaluation (rose). during the rose procedure, a cytotechnologist uses part of the sample to make a limited number direct smears which are then rapidly stained and evaluated under a microscope by the cytotechnologist. the cytotechnologist provides an assessment of the adequacy of the sample for diagnosis. the respirologist performing the ebus then uses this information to: i) determine whether additional sampling is required, and ii) triage any additional samples for ancillary studies as needed. a final cytopathological diagnosis is established several days later, when all of the material from the procedure (including the material not evaluated at rose) is examined by a cytopathologist. there are different techniques which are utilized to perform the needle aspiration biopsy. suction aspiration (where pressure suction is applied to the needle to draw out material) which is the standard at many centres around the world and capilliary suction (where a tiny wire is drawn back slowly to create more gentle suction force) which is utilized often at lhsc. the purpose of this study is to evaluate for differences in rose adequacy between these two methods.


Eligibility criteria:
inclusion criteria: * patient age greater to or equal than 18 years old * receiving an endobronchial ultrasound for any diagnostic reason exclusion criteria: * patients under 18 years old * patient refuses consent to undergo endobronchial ultrasound or is incapable of decision making.

Keywords: endobronchial ultrasound rapid-onsite cytologic evaluation procedure duration
endoscopy/robotic assisted nipple skin sparing mastectomy

Conditions: Breast Cancer Early Stage Breast Cancer (Stage 1-3); Breast Cancer Non-invasive Breast Cancer; High Risk Breast Carcinoma

Summary: non-inferiority study of video-assisted (endoscopic or robotic) skin- and nipple-sparing mastectomy compared to open mastectomy. the feasibility of the technique, oncological safety and cosmetic results will be studied.


Eligibility criteria:
inclusion criteria: * women who require a mastectomy and who do not require skin reduction or resection are included. women with both breast cancer and those at high risk for breast cancer are included. exclusion criteria: * sarcomas of the breast. * benign breast tumors. * prepectoral reconstruction with expansion. * impossibility to preserve the skin. * need for reduction pattern * inability to perform an mri during follow-up (obesity, claustrophobia, etc.). * inability to complete the breast-q™ questionnaire due to the patient's cognitive alterations. * refusal of the patient to participate in the study.
tako-tsubo cardiomyopathy and cardiac syndrome x: new insights into the pathophysiology

Conditions: Syndrome X; Takotsubo Cardiomyopathy

Summary: tako-tsubo cardiomyopathy (ttc) and cardiac syndrome x (csx) are respectively acute and chronic cardiac conditions whose clinical presentation, mimicking the onset of acute myocardial ischemia in absence of epicardial coronary disease, has progressively gained the interest of the scientific community. however, despite significant progress, their underlying pathophysiology, which seems to evoke some similarities, still remains elusive. endothelial dysfunction and autonomic imbalance have both been individually implied in their puzzling pathogenesis. the investigators plan to conduct our study in a cohort of ttc patients, csx patients and healthy volunteers with the following primary objective: to assess the response of endothelial function (through the endopat score) to the autonomic tone activation induced by a 10-minute stress mental test. the assessment of autonomic tone during activation through the evaluation of spontaneous baroreflex sensitivity (brs) and its correlation with endothelial function (endopat score) will represent secondary objectives. our study will enroll 15 patients with ttc at least six months after the event, 15 patients with classic csx and 15 healthy volunteers who will serve as control.


Eligibility criteria:
inclusion criteria: * patients with the mayo clinic's criteria established diagnosis of ttc at least 6 month after the acute event * patients with csx defined by the presence of anginal pain, positive exercise stress testing and negative coronary angiography. * a comparable cohort of healthy volunteers age and sex-matched with patients exclusion criteria: * short-term life-threatening pathology (life expectancy \< 6 months) * physically unable to participate in the study * compliance not guaranteed * pregnancy * conditions that make brs and endopat measurements impossible
improving in-hospital and post-discharge patient education for mild traumatic brain injury

Conditions: Concussion, Mild; Traumatic Brain Injury

Summary: the purpose of this study is to develop and validate ways to provide better patient education and clinical management for individuals who go to the emergency department (ed) with concussion or mild traumatic brain injury (mtbi).

the study will address three aims: (1) identify factors that help and hinder providing in-ed education to patients with mtbi prior to discharge; (2) examine the impact of tailored implementation strategies on ed providers' provision of in-ed patient education; and (3) evaluate the impact of providing patient education in the ed and through a mobile health (mhealth) tool post-discharge on patient-level outcomes after mtbi.

Eligibility criteria:
inclusion criteria: ed clinicians: • faculty attending physician, advanced practice professional (app), resident, fellow, or nurse who practices in an eligible froedtert \& medical college of wisconsin (mcw) emergency department patients-survey cohort: * seen and discharged from a froedtert \& mcw emergency department. * age 18 or older. * has a clinical diagnosis of tbi, as reflected by a relevant international classification of disease-10th edition (icd-10) code or other evidence (e.g., diagnosis and educational information in the after visit summary) * speaks english or spanish. patients-chart review only: * seen and discharged from a froedtert \& mcw emergency department. * age 18 or older. * has a clinical diagnosis of tbi, as reflected by a relevant icd-10 code or other evidence (e.g., diagnosis and educational information in the after visit summary). exclusion criteria: ed clinicians: • providers that do not practice in a froedtert \& medical college of wisconsin emergency department. patients-survey cohort. * on psychiatric hold. * is not own decision maker (e.g., activated healthcare power of attorney). * indicated do not contact in their research contact preferences. * left the emergency department prematurely (e.g., against medical advice). * history of serious health condition that, in the opinion of the investigator, would interfere with engagement in or validity of the survey (e.g., active thought disorder; terminal cancer; dementia). patients-chart review only: • minors under the age of 18.

Keywords: education systems of care emergency department implementation science