imaging of radiolabeled white blood cells in patients with non-hodgkin's lymphoma

Conditions: Lymphoma; Small Intestine Cancer

Summary: rationale: measuring the number of radiolabeled white blood cells in non-hodgkin's lymphoma tumors may help doctors predict how well patients will respond to treatment, and may help the study of cancer in the future. purpose: this study is measuring radiolabeled white blood cells in patients with non-hodgkin's lymphoma.

objectives: * determine the number of indium in 111-labeled peripheral blood mononuclear cells (pbmcs) and indium in 111-labeled polymorphonuclear leukocytes (pmnls) trafficking into lymphoma tumors prior to therapy in patients with non-hodgkin's lymphoma. * compare the number of pbmc and pmnl trafficking prior to vs after therapy in these patients. * compare, preliminarily, the number of in vivo baseline (i.e., pre-therapy) trafficking of pbmcs vs pmnls in these patients. * gather important data regarding the inter- and intra-patient variability of effector cell trafficking into these tumors. * assess the relationship between response at 8-12 weeks and the magnitude of baseline effector cell trafficking or the magnitude of post-rituximab effector cell trafficking in these patients. outline: this is a multicenter study. patients are assigned to 1 of 2 groups. * group i: patients receive autologous indium in 111 (\^111in)-labeled peripheral blood mononuclear cells on day 0. * group ii: patients receive autologous \^111in-labeled polymorphonuclear leukocytes on day 0. in both groups, patients undergo blood collection on day 0. patients then undergo full-body single-photon emission-computed tomography (spect) scan 4 hours after cell infusion and on day 2. the labeling and imaging process may be repeated after at least 1 course of anticancer treatment. cellular uptake is measured by reader/visual interpretation, a semiquantitative grading system, and tumor-to-background uptake ratios. projected accrual: a total of 100 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically or cytologically confirmed non-hodgkin's lymphoma * indolent or aggressive disease * planning to receive a new regimen or starting a regimen of cancer therapy * at least one tumor lesion measurable in two dimensions as ≥ 1.5 cm by ct scan patient characteristics: * ecog performance status (ps) 0-2 or karnofsky ps 60-100% * life expectancy ≥ 3 months * no concurrent medical complications that would preclude study compliance * not pregnant or nursing prior concurrent therapy: * at least 3 weeks since prior chemotherapy (except for nonmyelosuppressive treatments) * at least 3 weeks since prior radiation therapy * concurrent rituximab allowed

Keywords: aids-related peripheral/systemic lymphoma aids-related primary cns lymphoma anaplastic large cell lymphoma angioimmunoblastic t-cell lymphoma extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue intraocular lymphoma nodal marginal zone b-cell lymphoma primary central nervous system non-hodgkin lymphoma recurrent adult burkitt lymphoma recurrent adult diffuse large cell lymphoma recurrent adult diffuse mixed cell lymphoma recurrent adult diffuse small cleaved cell lymphoma recurrent adult immunoblastic large cell lymphoma recurrent adult lymphoblastic lymphoma recurrent adult t-cell leukemia/lymphoma recurrent cutaneous t-cell non-hodgkin lymphoma recurrent grade 1 follicular lymphoma recurrent grade 2 follicular lymphoma recurrent grade 3 follicular lymphoma recurrent mantle cell lymphoma recurrent marginal zone lymphoma recurrent mycosis fungoides/sezary syndrome recurrent small lymphocytic lymphoma small intestine lymphoma splenic marginal zone lymphoma stage iii adult burkitt lymphoma stage iii adult diffuse large cell lymphoma stage iii adult diffuse mixed cell lymphoma stage iii adult diffuse small cleaved cell lymphoma stage iii adult immunoblastic large cell lymphoma stage iii adult lymphoblastic lymphoma stage iii adult t-cell leukemia/lymphoma stage iii cutaneous t-cell non-hodgkin lymphoma stage iii grade 1 follicular lymphoma stage iii grade 2 follicular lymphoma stage iii grade 3 follicular lymphoma stage iii mantle cell lymphoma stage iii marginal zone lymphoma stage iii mycosis fungoides/sezary syndrome stage iii small lymphocytic lymphoma stage iv adult burkitt lymphoma stage iv adult diffuse large cell lymphoma stage iv adult diffuse mixed cell lymphoma stage iv adult diffuse small cleaved cell lymphoma stage iv adult immunoblastic large cell lymphoma stage iv adult lymphoblastic lymphoma stage iv adult t-cell leukemia/lymphoma stage iv cutaneous t-cell non-hodgkin lymphoma stage iv grade 1 follicular lymphoma stage iv grade 2 follicular lymphoma stage iv grade 3 follicular lymphoma stage iv mantle cell lymphoma stage iv marginal zone lymphoma stage iv mycosis fungoides/sezary syndrome stage iv small lymphocytic lymphoma waldenström macroglobulinemia stage i adult burkitt lymphoma stage i adult diffuse large cell lymphoma stage i adult diffuse mixed cell lymphoma stage i adult diffuse small cleaved cell lymphoma stage i adult immunoblastic large cell lymphoma stage i adult lymphoblastic lymphoma stage i adult t-cell leukemia/lymphoma stage i cutaneous t-cell non-hodgkin lymphoma stage i grade 1 follicular lymphoma stage i grade 2 follicular lymphoma stage i grade 3 follicular lymphoma stage i mantle cell lymphoma stage i marginal zone lymphoma stage i small lymphocytic lymphoma stage ii adult t-cell leukemia/lymphoma adult grade iii lymphomatoid granulomatosis adult nasal type extranodal nk/t-cell lymphoma recurrent adult grade iii lymphomatoid granulomatosis contiguous stage ii adult burkitt lymphoma contiguous stage ii adult diffuse large cell lymphoma contiguous stage ii adult diffuse mixed cell lymphoma contiguous stage ii adult diffuse small cleaved cell lymphoma contiguous stage ii adult immunoblastic large cell lymphoma contiguous stage ii adult lymphoblastic lymphoma contiguous stage ii grade 1 follicular lymphoma contiguous stage ii grade 2 follicular lymphoma contiguous stage ii grade 3 follicular lymphoma contiguous stage ii mantle cell lymphoma contiguous stage ii marginal zone lymphoma contiguous stage ii small lymphocytic lymphoma noncontiguous stage ii adult burkitt lymphoma noncontiguous stage ii adult diffuse large cell lymphoma noncontiguous stage ii adult diffuse mixed cell lymphoma noncontiguous stage ii adult diffuse small cleaved cell lymphoma noncontiguous stage ii adult immunoblastic large cell lymphoma noncontiguous stage ii adult lymphoblastic lymphoma noncontiguous stage ii grade 1 follicular lymphoma noncontiguous stage ii grade 2 follicular lymphoma noncontiguous stage ii grade 3 follicular lymphoma noncontiguous stage ii mantle cell lymphoma noncontiguous stage ii marginal zone lymphoma noncontiguous stage ii small lymphocytic lymphoma stage i mycosis fungoides/sezary syndrome stage ii mycosis fungoides/sezary syndrome stage ii cutaneous t-cell non-hodgkin lymphoma