Kornimate/medical-research-clean huggingface dataset:
adverse event prediction in geriatric patients in the ed with ultrasound

Conditions: Frailty; Adverse Event

Summary: the aim of this study is to evaluate whether ultrasound measurements of the qcsa can be utilized to identify older patients who are at risk for functional decline, ed revisit or death.

background: older people visit the emergency department (ed) more frequently then younger people and have a higher risk of functional decline, ed revisit or death. several screening tools (such as the dutch safety management system (vms) and acutely presenting older patient (apop)) have been developed to identify patients at the highest risk of adverse outcomes. almost all require adequate communication with the patient, which is not always possible, for example when elderly patients present with a delirium. point of care ultrasonography (pocus) may be a valuable alternative screening tool in these instances. main research question: to identify whether pocus measurement of the rectus femoris muscle cross-sectional area (qcsa) can be used as an alternative screening tool to predict functional decline, ed revisit or death in elderly patients in the ed. design (including population, confounders/outcomes): this is a single centre prospective trial. patients \>70 years and older presenting in the ed of the university medical centre groningen (umcg) who are participating in the acutelines bio-databank are eligible for inclusion. 68 patients will be included. data will be extracted from the acutelines bio-databank. a trained physician will perform ultrasound measurements in a standardized way. expected results: the aim of this study is to evaluate whether ultrasound measurements of the qcsa can be utilized to identify older patients who are at risk for functional decline, ed revisit or death.

Eligibility criteria:
inclusion criteria: * age (\>70 years) * presenting to the ed of the umcg for one of the following specialties: internal medicine, nephrology, geriatric medicine, oncology, hematology, lung medicine, gastrointestinal/liver medicine, or emergency medicine (non-trauma). * consent obtained for participation in the acutelines bio-databank exclusion criteria: * unable to obtain ultrasound image of rectus femoris (e.g. amputation, edema) * paresis or paralysis of one or both legs
scaling up small-scale food processing to promote food security among women farmers in rural vietnam

Conditions: Food Insecurity; Stunting; Wasting; Underweight; Anemia

Summary: this repeated measures, cluster randomized, cohort trial design was carried out in three provinces in the northern mountainous area of vietnam. communes here were randomly selected for community based interventions with local production complimentary foods and marketing and distribution of fortified complimentary foods.

in rural northern vietnam, childhood stunting rates are high. in lào cai province, female subsistence farmers grow crops, but face barriers sending produce to markets. the present intervention purchases local crops from local women subsistence farmers which are processed in local small-scale food processing facilities to produce instant fortified complementary foods for weaning. methods: a repeated measures survey was conducted from october to november 2016, with caregiver-child(\<2y) pairs (n=800) in the provinces of lai chau, lao cai and ha giang. anthropometric data of mother/child dyads was assessed and logistic regression analysis of stunted and underweight children explored associated factors. these included: core infant and young child feeding practices indicators, food insecurity, antenatal care check-ups, core water/sanitation, anemia and hygiene indicators. this project leveraged the experience of the national institute of nutrition of vietnam to ensure haccp standards during manufacture. locally grown rice was combined with a zn/fe premix before extrusion and hammer-milling. local vegetables such as: "sweet leaf" (sauropus androgynous), pumpkin, shiitake mushrooms (lentinula edodes) and carrots were made into complimentary foods and sold locally.

Eligibility criteria:
inclusion criteria: * child participants must be younger than 2y at baseline. * caregivers must volunteer and were required to give informed written consent exclusion criteria: * free from oedema * free from physical and mental disabilities * free from memory disorders and/or mental illness

Keywords: food insecurity stunting wasting underweight anemia complimentary foods food fortification complimentary feeding
prevalence of adrenal insufficiency in kidney transplanted patients in glucocorticoid treatment

Conditions: Adrenal Insufficiency

Summary: the primary purpose of this study is to determine the prevalence of adrenal insufficiency in a population of patients with kidney transplants receiving low dose prednisone treatment. development of glucocorticoid-induced adrenal insufficiency is a serious adverse effect to glucocorticoid treatment. the study includes a control group of patients with kidney failure currently treated in dialysis, who are not in glucocorticoid treatment. individual genotyping is performed to determine the haplotype of glucocorticoid receptor polymorphisms: n363 s, bcli, er23/23ek and 9β in all the patients with the purpose of investigating this as a risk factor for the development of adrenal insufficiency. the hypothesis is that subjects with one or another of the polymorphisms in the glucocorticoid receptor gene will either have increased or diminished glucocorticoid sensitivity. using validated questionnaires assessing the quality of life and functional level of the patients enrolled in the study we aim to establish a link between functional level and biochemically proven adrenal insufficiency. other secondary outcomes in the study includes bloodpressure, body composition, bone density, metabolic syndrome, inflammation and salivary cortisol profiles.

adrenal function is assessed in 30 prednisolon treated kidney transplanted patients and compared with 30 patients in dialysis, who are not treated with glucocorticoids. adrenal function is evaluated using a 250µg synacthen® test, performed fasting, in the morning, 48 h after the last prednisolone dose. cut-off for normal adrenal function is locally validated assay specific cut-off of 30 min p-cortisol \>420 nmol/l. the primary outcome measure of this study is p-cortisol concentrations 30 minutes after synacthen® injection in prednisolone treated patients compared with comtrols. secondary, 30 minutes p-cortisol is examined in relation to glucocorticoid receptor haplotypes. the genotyping is determined using polymerase chain reaction (pcr). the questionnaires used in this study includes eq-5d, sf-36, patient life situation form, cushingqol and addoqol.

Eligibility criteria:
inclusion criteria: * adult patients (\>18 years). * kidney transplated patients or patients with kidney failure treated in dialysis. * prednisone min 5 mg/day max 7,5 mg/day for the kidney transplanted patients (control group not treated with prednisone). exclusion criteria: * other major organ disease. * anemia with hemoglobin level less than 6,5 mmol/l. * not willing to pause any oestrogen tratment for a minimum of 6 weeks. * pregnancy. * not understanding danish language or otherwise not able to provide a written informed concent.
antibiotic resistance in global pediatric oncology centers

Conditions: Antibiotic Resistant Infection

Summary: antibiotic resistance is one of the major health threats facing global as well as domestic populations, however it is not well characterized in pediatric patients. pediatric patients receiving cancer-directed therapy have several risk factors implicated in development of antibiotic resistance including multiple courses of antibiotics, repeated exposures to the hospital environment, indwelling devices and chemotherapy-related damage to mucosal barriers. the investigators propose to capitalize upon the unique position of st. jude global within the global pediatric oncology community by using its regional alliance network to describe the molecular epidemiology of antibiotic resistance in gram-negative bacteria in this population. primary objectives 1. describe the epidemiology and the phenotypic and previously determined molecular determinants of antimicrobial resistance in gram-negative organisms isolated from pediatric diagnostic specimens in selected central american and us sites with capacity to treat pediatric cancer 2. utilize strain typing by whole genome sequencing to describe relatedness between organisms at participating sites

participating clinical microbiology laboratories will flag any gram-negative bacteria meeting inclusion criteria. bacteria will be subcultured; one sample will be lysed and shipped to st. jude; the remaining sample will be stored onsite for the duration of the study. samples of bacteria from both oncology and non-oncology patients will be included. whole genome sequencing will be performed on the bacterial samples at st. jude and the genotypic and phenotypic antimicrobial resistance testing (ast) results compared. genotypic results will additionally be used to describe phylogenetic relationships and potential transmission events both within and between sites. each participating location will collect limited clinical data corresponding to disease and treatment related factors on the affected patient. this will include sociodemographic variables, oncologic diagnosis, treatment phase, presence of a central venous catheter or other foreign body, antibiotic treatment within the past month, and previous history of colonization or infection by a resistant organism.

Eligibility criteria:
inclusion criteria: * pediatric (0-18 years of age) patients having a bacteria isolated from a sterile site (blood, cerebrospinal fluid, body fluid) or urine positive for a gram-negative bacteria nonsusceptible to at least 1 of the following: third generation cephalosporin, fourth generation cephalosporin or carbapenem or screening positive for carbapenemase or extended spectrum beta lactamase (esbl) production. exclusion criteria: * repeated isolation of the same organism from the same patient within the study period.

Keywords: antibiotic resistance gram negative bacteria pediatric patients
safety and efficacy of the toothwave powered toothbrush for extrinsic stain reduction (texas)

Conditions: Tooth Discoloration

Summary: this study is a single blind, prospective study aimed to evaluate the safety and efficacy of the silk'n toothwave powered toothbrush for stains reduction and improvement of teeth shade.

the study includes a total of 84 treatment sessions, twice a day, and 4 clinic visits over a period of 6 weeks. one treatment group (silk'n powered toothbrush - toothwave) and 1 control group (an ada approved powered toothbrush (ptb)) will participate in the study. for each patient, efficacy assessment data will be collected at baseline, 4 weeks, and at 6 weeks. the average stain data will be calculated for each group. treatment is defined as a timed, 2 minute brushing of the teeth according to the manufacturer's instructions, twice daily (morning and evening). brushing will be undertaken using the silk'n toothbrush and standard fluoride toothpaste. the control group will use an ada accepted ptb and standard fluoride toothpaste.

Eligibility criteria:
inclusion criteria 1. adult subjects aged 18-70, that are in good health. 2. subjects should have notable extrinsic dental stains on the 6 maxillary labial front teeth, or on the 6 mandibular front teeth (lingual or labial), with a total extrinsic tooth stain score ≥14 according to the lsi. 3. subject must have at least 2 natural anterior teeth, each having a mean lobene composite score of ≥ 1.5 as assessed by the investigator. 4. subject front teeth shade should be 9 or darker (meaning shade score should be between 9 and 29), as assessed by the vita bleachedguide 3d-master or the vita easyshade device. 5. the subjects should understand the information provided about the investigative nature of the treatment, possible benefits and side effects. subjects will sign the informed consent form. 6. the subjects should be willing to comply with the study procedure and schedule, including the follow up visits, and will refrain from using any other teeth whitening technologies during this period. 7. the subject did not perform any procedure for teeth whitening (either at home or in clinic) at least 3 years prior to participating in the study. exclusion criteria 1. pacemaker or internal defibrillator, or any other active electrical implant anywhere in the body. 2. pregnant or nursing by subject report. 3. any active condition in the oral cavity at the discretion of the investigator. 4. any surgery in the treated area within 3 months prior to treatment, or before complete healing. 5. subjects that do not brush regularly. 6. any condition that might make it unsafe for the subject to participate in the study, at the discretion of the investigator.
tear collection in adult volunteers

Conditions: Healthy Volunteers

Summary: this exploratory study will collect tear samples from adult volunteers for determining and quantifying tear composition profiles. no investigational drug will be administered in this study.


Eligibility criteria:
inclusion criteria: -adult volunteers without ocular disease. exclusion criteria: * systemic medications that could affect eye health taken within 1 month of enrollment * eye infection or inflammation in either eye 3 months prior to screening * history of herpes in either eye * diagnosis of dry eye or meibomian gland dysfunction * diagnosis of glaucoma * allergic conjunctivitis * use of rigid contact lenses within 1 year of screening * use of soft contact lenses within 1 week of enrollment.
optical genome mapping for the diagnosis of neurodevelopmental disorders

Conditions: Neurodevelopmental Disorder (Diagnosis)

Summary: to evaluate the ability of the optical genome mapping (ogm) approach to detect simple and complex constitutional chromosomal aberrations of clinical relevance, which had previously been identified with standard diagnostic approaches (karyotyping, fish, cnv-microarray) in the context of neurodevelopmental disorders (ndds) with/wo congenital anomalies (ca)


Eligibility criteria:
inclusion criteria: * subjects with neurodevelopmental disorders carrying a structural variant identified by standard cytogenetic analyses (karyotyping/fish/chromosomal microarray analysis) exclusion criteria: * none
the effect of positive end expiratory pressure (peep) during laparoscopic cholecystectomy

Conditions: Brain Ischemia

Summary: during the laparoscopic cholecystectomy, pneumoperitoneum could affect to the regional oxygen saturation of brain. positive end expiratory pressure (peep)could improve the respiratory parameters include oxygenation. so applying peep could improve the regional brain oxygen saturation (rso2)

during the laparoscopic cholecystectomy, pneumoperitoneum could affect to the regional oxygen saturation of brain due to increased intracranial pressure, central venous pressure and make worse to respiratory parameters. positive end expiratory pressure could improve the respiratory parameters include oxygenation. so applying peep could improve the regional oxygen saturation of brain during the pneumoperitoneum during the laparoscopic cholecystectomy.

Eligibility criteria:
inclusion criteria: * asa i or ii, * 20-65 year, * patient who undergoing laparoscopic cholecystectomy exclusion criteria: * cerebrovascular disease, * coronary artery disease, * morbid obesity (bmi \> 30) * propofol allergy, * addictive

Keywords: laparoscopic cholecystectomy peep rso2
the accuracy of ultrasonic viscoelastic imaging in evaluating the severity of chronic kidney diseases

Conditions: Chronic Kidney Disease(CKD)

Summary: the goal of this observational study is to learn about the role of ultrasonic viscoelastic parameters in the assessing the severity of chronic kidney disease. the main question it aims to answer is: the accuracy of ultrasonic viscoelastic parameters in evaluating the degree of renal fibrosis and inflammation.


Eligibility criteria:
inclusion criteria: * (1) fulfilled the diagnostic criteria for ckd (disease course \> 3months); (2) underwent renal biopsy, (3) a prior 2d-swe evaluation preceding the renal biopsy, and (4) obtained informed written consent. exclusion criteria: * (1) the presence of multiple renal cysts, calculi, hydronephrosis, or masses that could potentially interfere with the analysis conducted through 2d-swe: (2) unsuccessful 2d-swe measurements ;(3) biopsy specimens deemed inadequate due to insufficient length (less than 10 mm) or fewer than 10 glomeruli, and (4) incomplete clinical data.

Keywords: chronic kidney disease sonoelastogrphy fibrosis inflammation
impact of a monitoring device for patients with cancer treated using oral therapeutics

Conditions: Metastatic Cancer; Hematological Malignancy

Summary: the emergence of oral delivery in cancer therapeutics is expected to result in an increased need for better coordination between all treatment stakeholders, mainly to ensure adequate treatment delivery to the patient. there is significant interest in the nurse navigation program's potential to improve transitions of care by improving communication between treatment stakeholders and by providing personalized organizational assistance to patients. the use of health information technology is another strategy aimed at improving cancer care coordination that can be combined with the nn program to improve remote patient follow-up. however, the potential of these two strategies combined to improve oral treatment delivery is limited by a lack of rigorous evidence of actual impact. the investigators are conducting a large scale randomized controlled trial designed to assess the impact of a navigation program denoted capri that is based on two nurse navigators and a web portal ensuring coordination between community and hospital as well as between patients and navigators, versus routine delivery of oral anticancer therapy. the primary research aim is to assess the impact of the program on treatment delivery for patients with metastatic cancer, as measured by relative dose intensity. the trial involves a number of other outcomes, including toxic side effects, patient quality of life and patient experience . an economic evaluation adopting a societal perspective will be conducted, in order to estimate those health care resources' used. a parallel process evaluation will be conducted to describe implementation of the intervention


Eligibility criteria:
inclusion criteria: * patients (male or female) aged \> 18 years * life expectancy \> 6 months * patients with tumour or hematological malignancy being treated at gustave roussy * patients with oral therapy (cytotoxic or targeted therapies) * patients starting therapy * patients living in france * patients affiliated to a social security system or equivalent * oms score from 0 to 2 at the time of inclusion * signed inform consent * patients able to follow protocol exclusion criteria: * patients being treated with hormonotherapy only * patients enrolled in a clinical trial ongoing treatment with an experimental compound except in the case where the sponsor agrees that the capri protocol is not intefering with the trial * not french speaking patients * patients deprived of liberty * patients with no internet access or telephone line
the individual and family self management theory based epilepsy education program's effectiveness

Conditions: Self Management; Epilepsy; Seizure; Quality of Life

Summary: the aim of the study; to determine the effect of education program given to adolescents diagnosed with epilepsy and their parents based on ryan and sawin's individual and family self-management theory, on adolescents 'attitudes towards disease, self-efficacy, quality of life and parents' nurse-parent support levels.

in addition to the expected effects of epilepsy on children, the course of the disease and the course of the child's life will change as the duration of life with the disease increases. in epilepsy, it is necessary to develop self-management behaviors in order to facilitate adaptation to the disease, to encourage seizure control and to increase the quality of life. regular repetition of the trainings created within the framework of a certain plan to improve self-management behaviors is one of the recommended steps to strengthen the individual with chronic disease in the disease process. this randomized controlled study including aged 12-18 adolescents with a diagnosis of epilepsy, monotherapy, mental retardation without cerebral palsy, and no secondary disease and their parents. however, there isn't enough published research examining the effect of education program given to adolescents diagnosed with epilepsy and their parents based on ryan and sawin's individual and family self-management theory, on adolescents 'attitudes towards disease, self-efficacy, quality of life and parents' nurse-parent support levels.

Eligibility criteria:
inclusion criteria: * having a diagnosis of epilepsy for at least 6 months, * being in the age range of 12-18 years, * cerebral palsy, attention deficit, lack of mental retardation, except for a different physical or epilepsy, * receiving monotherapy treatment for epilepsy * to be able to communicate in turkish exclusion criteria: * cerebral palsy, attention deficit, mental retardation other than epilepsy, * patients who are over the age of 18 or who switch to an adult care program, * not being open to communication and cooperation, not taking polytherapy * adolescents not continuing the monitoring phase or wanting to stop working at any stage, * prior history of seizures due to screen exposure

Keywords: epilepsy self-management chronic disease adolescent education