Kornimate/medical-research-clean huggingface dataset:
feasibility and efficacy of neoadjuvant cabozantinib plus nivolumab (cabonivo) followed by definitive resection for patients with locally advanced hepatocellular carcinoma (hcc)

Conditions: Locally Advanced Hepatocellular Carcinoma

Summary: the proposed study is an open-label, single institution, single arm phase 1b study of neoadjuvant cabozantinib plus nivolumab in patients with locally advanced hcc.


Eligibility criteria:
inclusion criteria: 1. must have locally advanced/borderline resectable hepatocellular carcinoma. 2. must have measurable disease. 3. age ≥18 years. 4. eastern cooperative oncology group (ecog) performance status 0 or 1. 5. patients must have adequate organ and marrow function defined by study-specified laboratory tests. 6. patients must have adequate liver remnant and function. 7. antiviral therapy per local standard of care for hepatitis b. 8. woman of child bearing potential must have a negative pregnancy test. 9. must use acceptable form of birth control while on study. 10. ability to understand and willingness to sign a written informed consent document. exclusion criteria: 1. fibrolamellar carcinoma or mixed hcc. 2. chemotherapy, radiotherapy, investigational therapy, or surgery less than 6 months prior to trial registration. 3. concomitant anticoagulation therapy. 4. any gi or pulmonary risks of bleeding. 5. history of hiv infection. 6. active co-infection with hepatitis b and hepatitis c. 7. active co-infection with hepatitis b and hepatitis d. 8. has a diagnosis of immunodeficiency, or is receiving systemic steroid therapy. 9. history of any autoimmune disease requiring systemic treatment within the past 2 years. any patient bearing an allograft is not eligible. 10. any additional malignancies with treatment or life-limiting cancers. superficial bladder cancer, non-melanoma skin cancers, or low grade prostate cancer not requiring therapy would not exclude participation in this trial. 11. uncontrolled intercurrent illness. 12. corrected qt interval calculated by the fridericia formula. 13. uncontrolled high blood pressure. 14. are pregnant or breastfeeding. 15. any gastrointestinal (gi) disorders. 16. any certain study-specified heart conditions 6 months prior to enrollment. 17. major surgery within 2 months before enrollment. 18. have any evidence of moderate or severe ascites. 19. any untreated or incompletely treated varices with bleeding or high-risk bleeding. 20. inability to swallow intact tablets. 21. known or suspected hypersensitivity to study treatment.

Keywords: nivolumab cabozantinib neoadjuvant immunotherapy liver cancer borderline resectable advance resectable neoplasms hepatocellular carcinoma hcc resection
effects of deep breathing excer. with & without pmr on post c section lbp, qos & pa

Conditions: Cesarean Section Complications

Summary: to find out the effects of deep breathing exercises with and without progressive muscle relaxation technique on post cesarean section low back pain, quality of sleep and physical activity


Eligibility criteria:
inclusion criteria: * females who had caesarian section * age 20-35 years * no contraindications to exercise stated by an obstetrician exclusion criteria: * females having heart disease, * females with diabetes mellitus, * pre-eclampsia or eclampsia * complications during the operation * diseases of the nervous system, e.g. ms, stroke, respiratory diseases, diabetes, cancer \&rheumatic diseases

Keywords: cesarean section deep breathing excercises low back pain progressive muscle relaxation physical activity quality of sleep
outcomes in stevens johnsons syndrome and toxic epidermal necrolysis

Conditions: Stevens-Johnson Syndrome; Toxic Epidermal Necrolysis; Drug Reaction

Summary: this is a prospective, multicenter cohort observational; study to compare treatment outcomes in patients admitted to the hospital with stevens-johnsons syndrome/toxic epidermolysis, aiming to assess the utility of medical management. the hypothesis of this study is that one or more treatment options will demonstrate improved patient outcomes. the primary objectives are cessation of progression of disease, time to complete re-epithelialization, length of stay, and mortality rate in the treatment groups as compared to those receiving supportive care alone. exploratory analyses will assess the cause, risk factors, and severity prediction factors associated with the disease.


Eligibility criteria:
inclusion criteria: * a diagnosis of stevens johnsons syndrome/toxic epidermal necrolysis confirmed by examination of a dermatologist and/or skin biopsy plus described appropriate clinical findings (epidermal necrosis plus two involved mucosal surfaces) presenting within one week of disease onset exclusion criteria: * pregnancy * age \<18y * decisional impairment * incarceration * onset of skin separation \>7d
the instant effect of kinesiology taping in patients with knee oa

Conditions: Osteoarthritis, Knee

Summary: the aim of this study is to determine instant effect of kinesiology taping applied to the rectus femoris on muscle activation, physical performance and proprioception in patients with knee osteoarthritis.

40 patients with knee oa will be included in the study. intervention group and placebo group will be formed. facilitation taping will be applied on the rectus femoris of the patients in the taping group. the patients in the placebo group will be placed tape on the rectus femoris without any tension. muscle activation, physical performance and proprioception will be evaluated before taping and 30 minutes after taping.

Eligibility criteria:
inclusion criteria: * patients aged 45-65 years, * patients with independent ambulation, * patients with grade ii-iii knee osteoarthritis according to the kellgren and lawrence classification, * patients not using nsaids during the study, * patients who volunteered to participate in the study exclusion criteria: * patients with previous surgery on the lower extremities * patients with neuromuscular disease * patients with vestibular pathology * patients with diseases of the cardiopulmonary system, * patients with communication difficulties, * patients who have received physiotherapy or intra-articular injections in the last 6 months or who exercise

Keywords: knee osteoarthritis kinesiotape physical performance muscle activation
mrd in paad adjuvant therapy

Conditions: The Role of Molecular Residual Disease in the Treatment Strategy and Prognosis Prediction of Pancreatic Cancer Patients Undergoing Adjuvant Therapy; Molecular Residual Disease; Pancreatic Cancer; Adjuvant Therapy

Summary: our preliminary research has explored the detection efficacy of minimal residual disease (mrd) in pancreatic cancer. in patients with pancreatic cancer undergoing dual-agent adjuvant chemotherapy, the median recurrence-free survival (rfs) is approximately 13.9 months. due to the high postoperative recurrence rate, short survival time, and intense systemic chemotherapy in pancreatic cancer patients, there is an urgent clinical need to more accurately identify which patients will benefit from adjuvant therapy. this study aims to evaluate the application value and guiding significance of peripheral blood mrd in the decision-making process for adjuvant treatment in patients with resected pancreatic cancer.


Eligibility criteria:
inclusion criteria: * here's the translated and polished version of your content: 1. patients clinically diagnosed with pancreatic cancer, staged i-iii (ajcc v8.0), who are scheduled to undergo curative surgery. 2. no restrictions on gender; age between 18 and 70 years. 3. eastern cooperative oncology group (ecog) performance status score: ≤2. 4. expected survival time of ≥3 months. 5. willingness to comply with the study protocol for testing, treatment, and follow-up; consent to provide necessary clinical, pathological, and follow-up data for the study; and agreement to use the research data for future studies and product development. 6. voluntary participation in this clinical study, with an understanding of the study procedures and the ability to sign an informed consent form. exclusion criteria: 1. patients who have had other malignancies within the five years prior to this study. 2. patients who have received any antitumor treatment within six months prior to enrollment. 3. patients with concomitant diseases that, in the investigator's judgment, pose a serious risk to patient safety or could affect the patient's ability to complete the study (such as poorly controlled hypertension, severe diabetes, thyroid disorders, psychiatric disorders, etc.), or any other conditions deemed unsuitable for participation.

Keywords: pancreatic cancer
removing background talker noise for cochlear implant users

Conditions: Hearing Loss

Summary: when hearing-impaired listeners are properly aided with a hearing aid (ha) or cochlear implant (ci), they are often able to comfortably maintain a conversation in quiet environments. however, in group environments, such as a large family dinner, restaurant, or other environment where multiple people are talking simultaneously, hearing-impaired listeners have great difficulty participating in conversations and frequently withdraw or avoid the situation. as such, it would be highly beneficial to implement an algorithm into has or cis to remove background talkers ("babble") from the signal to reduce listening effort for the hearing-impaired listener and allow them to converse as if they were in a quiet environment. although has and cis frequently incorporate noise reduction algorithms, these algorithms are not effective when the background is babble. the problem of removing babble involves segregating speech from speech. hence, the spectral properties of the signal and noise are extremely similar. despite these challenges, we developed an algorithm to remove background babble. in the following study will test the ability of cochlear implant users to understand speech with background babble noise using our noise reduction algorithm or no noise reduction algorithm. we hypothesize that ci users will be able to understand significantly more speech in babble noise when using our algorithm.


Eligibility criteria:
inclusion criteria: subjects with cis 12 years of age and older with no diagnosis of other communicative or cognitive disorders. subjects must have native or native-like english proficiency. exclusion criteria: no diagnosed cognitive or communicative disorders (other than hearing loss), presence of acute/chronic otitis media, useable acoustic hearing, and non-english speaking.
potential associations between alterations in gut microbiome and obesity-related traits after the bariatric surgery

Conditions: Obesity; Bariatric Surgery

Summary: this study aimed to examine the effects of obesity and bariatric surgery on gut microbiota in a turkish population, and to contribute to the literature by bringing multi-dimensional parameters including dietary intake, metabolic and inflammatory markers. this case-control study was conducted between june 2015 and august 2019. all participants were followed during the six-month period. face-to-face interviews and physical examinations were held, and blood and fecal samples were collected at the baseline (m0) and at the end of 3 (m3) and 6 months (m6). dietary intakes of subjects were assessed using 24-h dietary recall method in each interview and a detailed quantitative food frequency questionnaire that involved 85 food items. subjects were recruited to the study as three groups: 15 patients who had bariatric surgery as study group, 8 morbidly obese participants who did not have bariatric surgery as control group-1 and 11 participants who were non-obese (lean (n=5) and pre-obese (n=6)) as control group-2. all subjects in the study group had sleeve gastrectomy. subjects in control groups were selected as age and gender matched with the participants in the study group. individuals were excluded if (a) they were under 19 or above 65 years old, (b) they had an acute or chronic inflammatory disease, (c) they were diagnosed with infectious diseases, cancer or alcohol addiction, (d) they used antibiotics in last 3 months before the screening.


Eligibility criteria:
inclusion criteria: * morbidly obese participants for study and control group-1 * non-obese participants for control group-2 exclusion criteria: * they were under 19 or above 65 years old, * they had an acute or chronic inflammatory disease, * they were diagnosed with infectious diseases, cancer or alcohol addiction, * they used antibiotics in last 3 months before the screening.

Keywords: obesity bariatric surgery gut microbiome diet
effects of low-volume aerobic interval training in overweight individuals at increased cardiometabolic risk

Conditions: Overweight and Obesity; Metabolic Syndrome

Summary: the main purpose of this study is to compare the impact of aerobic interval training intensity on exercise adherence and changes in cardiorespiratory fitness, cardiometabolic risk profile, body composition, inflammatory markers and subjective health outcomes after a 12-week intervention trial in overweight individuals at increased cardiometabolic risk.


Eligibility criteria:
inclusion criteria: * body mass index \>/=30 * presence of at least 2 cardiometabolic risk factors exclusion criteria: * healthy persons or patients under age * overweight persons without any additional cardiometabolic risk factors * pregnancy, lactation * psychological disorders, epilepsy, sever neurological disorders * participation in other exercise- or nutrition studies within the last 6 months * acute cardiovascular disease * malignant disease * electronic implants (defibrillator, pacemaker) * persons in mental hospitals by order of authorities or jurisdiction

Keywords: aerobic exercise interval training vo2max health promotion inflammation body composition
psorcast mobile study

Conditions: Psoriatic Arthritis; Psoriasis; Psoriatic Conditions; Dermatologic Disease; Rheumatologic Disease; Psoriatic Nail; Plaque Psoriasis; Joint Pain; Dactylitis

Summary: the purpose of this study is to understand variation in the symptoms of psoriasis and psoriatic arthritis using simple, scalable smartphone-based measurements. this study uses an iphone app to record these symptoms through questionnaires and sensors.

psoriatic disease exhibits a spectrum of symptoms and can transition from psoriasis (pso), largely affecting the skin, to psoriatic arthritis (psa) involving widespread musculoskeletal inflammation. early detection of the pso-to-psa transition and rapid administration of effective treatment is essential, as a delay in diagnosing psa by as little as 6 months can lead to irreversible joint damage. this "ticking clock" paradigm drives the need for frequent monitoring and effective therapeutic intervention as early as possible to attenuate or possibly prevent disease progression. using a suite of smartphone-based measurements in an app called psorcast (psoriasis forecasts), we aim to aggregate weekly, symptom measurements from participants in a remote, longitudinal observational study to map the trajectories of treatment response and disease progression. in this study, we will explore measurements of psoriatic disease activity at least an order of magnitude more frequently (weekly vs. quarterly) than standard clinical practice or clinical trial designs. this study is not meant to provide a medical diagnosis, treatment, or medical advice. it is meant to provide a scalable, inexpensive, non-invasive and frequent measure and tracking of psoriasis and psoriatic arthritis for research purposes.

Eligibility criteria:
inclusion criteria: * adult age 18 and older who consent to participate in the study * own a compatible iphone or ipod touch device running ios 12.2 or above * be able to read and understand an official language of the country of participation exclusion criteria: * age 17 years or younger * not a resident of the a country where the app is approved for use * not have a personal (i.e., not shared) iphone (4s or newer running ios 8.0 or later) * not be able to read and understand an official language of the country of participation

Keywords: psoriasis psoriatic arthritis psoriatic disease health app research mhealth research mobile health research
a randomized, placebo-controlled, double-blind, single ascending dose study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of bms-986104 in healthy male subjects

Conditions: Rheumatoid Arthritis

Summary: the primary objective in this study is to assess if single doses of bms-986104 that are safe, tolerable, and result in sufficient lymphopenia (50% to 70% reduction in absolute lymphocyte count) can be achieved without bradycardia or other adverse events in healthy male subjects.


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com. inclusion criteria: * healthy male subjects as determined by medical history, physical examination, vital signs, 12-lead electrocardiogram (ecg), and clinical laboratory evaluations will be eligible to participate in the study * men ages 18 to 49 years, inclusive exclusion criteria: * any acute or chronic medical illness judged to be clinically-significant by the investigator and/or sponsor medical monitor * presence of fecal occult blood at screening * history of prolonged occupational exposure to organic solvents or pesticides * history of vitamin b12 deficiency and/or achlorhydria; or a vitamin b12 level at screening \<lower limit of normal (lln), confirmed by repeat test * history of guillain-barré syndrome * past or current history of central or peripheral neuropathies, or past or current symptoms of sustained or recurrent paresthesias (tingling), numbness, or neuropathic pain (burning, aching or stabbing) in any extremities. note: experiencing an extremity "falling asleep" occasionally is not be exclusionary * clinically significant abnormality in the neurological exam at baseline (predose) * clinically significant nerve electrophysiology abnormalities at baseline (predose) * any history of testicular or epididymal disease/disorder * clinically significant abnormality on ophthalmologic exam or any findings suggesting an increased risk of macular edema at baseline (predose) * history of hypothyroidism or carpal tunnel syndrome * subjects with history of diabetes mellitus * subjects with history of any type of heart disease, including ischemia, infarction, arrhythmias, hypertension, atrioventricular block of any degree, bradycardia, syncope, clinically significant ecg abnormalities, or any congenital heart disease * subjects with any acute or chronic bacterial, fungal or viral infection within the last 3 months prior to screening, as well as any febrile illness of unknown origin within 14 days of screening * subjects who have received any live vaccines within 1 month of study drug administration or who plan to have a live vaccine at any time during the study * positive test for tuberculosis at screening (quantiferon® gold)
the effect of yoga exercises and callisthenic exercises on the quality of life in healthy individuals

Conditions: Quality of Life; Exercise

Summary: in this study, healthy individuals will be asked to do yoga exercises or a calisthenic exercise program. the effect of different exercise programs on quality of life will be investigated.

while yoga was a part of the philosophy of life in india, today it has become widespread as a physical and mental practice and has become a preferred approach to protect and improve physical functions, especially in healthy individuals. the word yoga means "union" and "unity". it is a group of practices or disciplines that mainly include physical movements , special breathing techniques and deep concentration. a study on this subject has shown that yoga training applied to healthy individuals increases muscle strength, muscle endurance and flexibility, and reduces stress levels. calisthenic exercises; these are exercises that are performed by creating resistance only with your body weight, without the need for any equipment or gym. calisthenic exercises are aerobic and dynamic exercises. calisthenics exercises are a useful and useful exercise method that can be done at a fast pace, at different intensities, and can also be modified. calisthenic exercises should be rhythmic and performed by counting. a study on this subject has shown that calisthenic exercises improve muscle strength and balance. in this study, healthy individuals will be asked to do yoga exercises or a calisthenic exercise program. the effect of different exercise programs on quality of life will be investigated.

Eligibility criteria:
inclusion criteria: 1. the ages of 18 - 45 2. no communication problems 3. not having had a surgical operation in the last 6 months exclusion criteria: 1. individuals with musculoskeletal system problems that prevent them from exercising 2. individuals who have respiratory problems when their physical activity increases 3. individuals with a history of chest pain related and unrelated to physical activity 4. individuals with chronic diseases
ear acupuncture for acute sore throat.

Conditions: Acute Sore Throat

Summary: the purpose of this study is to compare ear acupuncture plus standard of care versus standard therapy (anti-inflammatory medications) in the reduction of pain, reduction in oral anti inflammatory medication use, hours lost from work in acute sore throat.


Eligibility criteria:
inclusion: * male and female subjects (dod beneficiaries), 18 years or older, with upper respiratory complaints and their primary symptom being acute sore throat. * minimum pain score of 5 points on an 11 point scale (0-10 with 10 being the worst pain) exclusion: * history of significant gastrointestinal bleed * previous documented history of stage 2 kidney disease or worse * known pregnancy * history of gastric bypass surgery * known peritonsillar abscess (pta) * throat, mouth or esophageal cancer * chronic oral steroids use * absence of one or more ears * active cellulitis of ear * ear anatomy precluding identification of acupuncture landmarks * non-english speaking * use of hearing aids that preclude the use of ear acupuncture * allergy to ibuprofen

Keywords: acute sore throat ear acupuncture