Kornimate/medical-research-clean huggingface dataset:
the stockholm sleepy brain study: effects of sleep deprivation on cognitive and emotional processing in young and old

Conditions: Sleep Deprivation

Summary: the main purpose of this study is to investigate the effects of partial sleep deprivation (psd) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.


Eligibility criteria:
inclusion criteria: * 20-30 years of age, inclusive or 65-75 years of age, inclusive * able to understand spoken and written swedish (in order to understand instructions) * normal or corrected-to-normal vision not using glasses * not colour blind * right-handed * free from ferromagnetic objects in body * no history of any neurologic or psychiatric illness including drug abuse * no history of diabetes nor hypertension * no depression according to ratings using the hospital anxiety and depression scale (had) * no insomnia according to ratings using the insomnia severity index (isi) and karolinska sleep questionnaire (ksq) * no use of psychotropic drugs * not studying or working in medicine, psychology, nor behavioural science * not suffering from severe seasonal allergy * no use of cortisone, anti-histamines, nor any other immune-modulating drugs * habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine * no daily use of nicotine exclusion criteria: -

Keywords: sleep resting state functional connectivity emotional contagion empathy emotional regulation
visn 19 mirecc research database

Conditions: Demographic Data; History of Medical and Mental Health; History of Combat Experience; History of Suicide; Imaging Results

Summary: the visn 19 mirecc is involved in research concerned with suicide prevention in high risk populations (e.g., history of traumatic brain injury, post-traumatic stress disorder); recruitment for future studies will continue with a similar focus. the aim of this protocol is for the visn 19 mirecc research database (v19-mrd), to have a data repository of participants for possible recruitment from other studies being conducted at the visn 19 mirecc. the visn 19 mirecc conducts numerous research projects under the review of comirb and the va r\&d.

this protocol seeks to formally create the database that will store demographic data. the data will be used by visn 19 mirecc investigators solely for recruitment purposes for future studies. the repository data will include: 1. data regarding individuals in existing study databases who have already provided permission to have their information stored and used for future recruitment into visn 19 mirecc research studies (specific data elements to be collected will be articulated below). 2. data of individuals to be collected and saved to use for future recruitment into visn 19 mirecc research studies. a restricted section of the v19-mrd will contain v19-mrd identification numbers and identifying data including name (first, last, middle initial), social security number, phone number(s) (primary and secondary), date of birth, and mailing address. a less restricted section of the v19-mrd will contain v19-mrd identification numbers, the comirb protocol number of the study the participant was recruited from, gender, year of birth, and criteria identifiers marked as present or absent (i.e., history of medical and mental health conditions, history of suicide - thoughts/behaviors, history of combat experience, and presence of imaging results). the v19-mrd would enhance current research strategies by first allowing visn 19 mirecc investigators an efficient method to conduct preliminary or ongoing investigations to determine if: 1) sufficient populations exist to conduct a study; or 2) potential participants meeting specific study criteria are included in the database who could be contacted regarding study participation. second, with an approved protocol, the v19-mrd contact section of the database could be used to facilitate mailings to potential participants.

Eligibility criteria:
inclusion criteria: * being a patient at the denver va medical center * 18 years or older * participated in another study at the visn 19 mirecc exclusion criteria: * not a patient at the denver va medical center * younger than 18 years * never participated on a study within the visn 19 mirecc

Keywords: data repository facilitate recruitment of participants for ongoing and future research
study to examine effect of cp-866,087 on consumption and craving of alcohol in alcohol dependent subjects.

Conditions: Alcoholism

Summary: test the hypothesis that increasing doses of cp-866,087 will decrease the total number of drinks consumed during a 2 hour acute alcohol consumption assessment and to determine the safety and tolerability of multiple doses of cp-866,087 in alcohol dependent subjects compared to placebo.


Eligibility criteria:
inclusion criteria: * subject meets the dsm-iv criterion for current alcohol dependence. * subject is currently not engaged in, and does not want, treatment for alcohol related problems. exclusion criteria: * subject meets criteria for current dsm-iv diagnosis for any other psychoactive substance abuse or dependence disorder, excluding nicotine and caffeine. * specialized inpatient or outpatient alcoholism or other addiction treatment (except nicotine) within the past 12 months.
relationship of endoplasmic reticulum stress and tonsillar tissue diseases

Conditions: Tonsillitis; Tonsillar Hypertrophy; Immune System Diseases

Summary: tonsillar tissue is a significant organ for the performing of immune systems in children. the endoplasmic reticulum (er), is an organelle needed for the care of a stable function of the cells. the purpose of the study was to explore the correlation among er stress and tonsillar tissue disorders and to explain the structure of diseases related to the immune system.

a prospective study was conducted on 46 children aged who underwent tonsillectomy for chronic tonsillitis or tonsil hypertrophy. tonsil tissues were evaluated in terms of er stress markers and apoptosis markers by real-time pcr and western blot methods.

Eligibility criteria:
inclusion criteria: * patients who underwent tonsillectomy surgery with the clinical diagnosis of chronic tonsillitis and tonsillar hypertrophy. exclusion criteria: * systemic diseases * other otolaryngological disorders

Keywords: endoplasmic reticulum apoptosis i̇mmune system
golf, physical rehabilitation, and movement disorders

Conditions: Parkinson Disease, Movement Disorders

Summary: the importance of physical activity for individuals with movement disorders, including parkinson disease and essential tremor, has been established. barriers including patient engagement continue to limit effectiveness. golf requires skills found challenging to individuals with movement disorders. this study seeks to assess the feasibility and effectiveness of an outpatient-based rehabilitation program incorporating golf skills and activities on functional measures and quality of life.


Eligibility criteria:
inclusion criteria: * diagnosis of either pd, parkinsonism, or et. subjects must also demonstrate functional deficits in at least one of the three categories (gait, transfers, balance) to be further assessed by the evaluating pt exclusion criteria: * subjects will be excluded if they are unable to maintain standing balance with an assistive device, if they are non-ambulatory even with a device, if pain does not allow for subject participation, and if they are unable to follow instructions due to an underlying attentional or cognitive deficit.
lactulose supplementation in premature infants

Conditions: Necrotizing Enterocolitis; Sepsis

Summary: a pilot study to test the safety of use of lactulose in preterm infants and to preliminary assess the hypothesis that lactulose would support the early growth of lactobacilli in the stools of premature infants and possibly would also improve nutritional status and decrease nec and late-onset sepsis.

prospective, double-blind, placebo-controlled single center pilot study in 23-34 weeks gestation premature infants. study group will receive 1% lactulose, while control group will receive 1% dextrose placebo in all their feeds (human milk or preterm formula). clinical parameters will be followed. stool samples will be sent for culture.

Eligibility criteria:
inclusion criteria: premature infants were recruited based on the following criteria: * 23-34 weeks' gestation (as determined by a combination of maternal dates, early prenatal ultrasonography and postnatal gestational age estimation based on physical and neuromuscular signs (new ballard score), as long as there will be gestational age agreement between the 3 methods \< 2 weeks); * absence of major congenital malformations; and * informed consent obtained from parents. exclusion criteria: * major congenital malformations and parental refusal.

Keywords: lactulose prebiotic premature infant enteral feeding stools lactobacillus nutrition growth
no drainage during transoral endoscopic thyroidectomy vestibular approach(toetva)

Conditions: Drainage; Thyroid Cancer

Summary: this study evaluates the viability and safety of no drainage tube placement during transoral endoscopic thyroidectomy vestibular approach in treatment of patients with papillary thyroid carcinoma.

transoral endoscopic thyroidectomy vestibular approach (toetva) is widely used due to its excellent cosmetic effect without scars on the body surface. in prevention of postoperative hemorrhage, a postoperative drainage tube is routinely placed in the surgical area. however, current opinion suggest that under the circumstance of strict and effective intraoperative hemostasis, routine application of drainage tube is unnecessary in conventional open thyroidectomy(cot). the research about drainage placement decision during endoscopic thyroidectomy is scarce currently. this study evaluates the viability and safety of no drainage tube placement during toetva on papillary thyroid carcinoma. patients allocated to the intervention group will implace no drainage tube during toetva and those allocated in control group will implace one drainage tube routinely. the incidence of postoperative complications will be evaluated. the time of postoperative hospital-stay and operation time will be evaluated as well. at the same time, blood test results like wbc and crp will be evaluated 1 day after surgery.

Eligibility criteria:
inclusion criteria: 1. patients undergoing thyroid surgery for the first time 2. the surgical method is toetva 3. there is no lateral cervical lymph node metastasis assessed before surgery 4. fine-needle aspiration revealed palpilary thyroid carcinoma 5. it meets the surgical indications and has no obvious surgical contraindications exclusion criteria: 1. previous history of thyroid surgery; 2. conventional open thyroidectomy, endoscopic thyroidectomy areola approach or axillary approach; 3. patients undergoing cervical lateral lymph node dissection; 4. past or current history of hyperthyroidism; 5. history of combined hypertension, diabetes, coagulation dysfunction, or other important organ dysfunction diseases.

Keywords: drainage toetva palpilary thyroid carcinoma complications
evi-01-it safety study

Conditions: Knee Osteoarthritis

Summary: prospective, single arm, pilot study to assess the safety and tolerability of a single intra-articular injection of evi-01 for the treatment of symptomatic knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * eighteen (18) years old or above; * patient signed informed consent form; * patients with stable symptoms related to knee osteoarthritis for at least 3 months prior to screening; * failure, inadequate response or intolerance to analgesics and/or nsaids or low-grade opioids; * kellgren-lawrence radiographic stage: ii-iii diagnosed in the previous 12 months; * womac average pain index score \> 40 mm and \< 90 (on a vas 0-100 mm) on the knee to be treated; * difference ≥ 10 mm between the womac average pain score of the knee to be treated and womac average pain score of the contralateral knee at screening; * body mass index (bmi) inferior to 35 kg/m2 (weight/height). exclusion criteria: * concomitant inflammatory joint disorder; * had received previous visco-supplementation treatment in the study knee within 6 months or intra articular corticosteroids within 3 months\* prior to inclusion; * infection in or around the study knee; * relevant skin disease in the area of injection site; * documented presence of injury or trauma of the study knee at screening, including evidence of a subchondral fracture, meniscal lesion, presence of bone or cartilage fragments in the study knee; * history of allergy or intolerance to sodium hyaluronate; * documented presence of osteonecrosis in one or both knees; * inability to understand the study procedure; * participation in another clinical trial within 30 days prior to screening; * ongoing therapy with daily dosage \> 101 mg of acetylsalicylic acid as part of cardiovascular preventive treatment. if dose \< 101 mg, it must be maintained during the study; * pregnant or breast-feeding at inclusion. * 1 month = 30 days

Keywords: highly concentrated hyaluronic acid knee osteoarthritis
the effect of lumify™ on ocular redness, intraocular pressure, and eyelid position in glaucoma patients

Conditions: Glaucoma; Glaucoma, Open-Angle; Glaucoma; Drugs; Droopy Eyelid; Ptosis; Glaucoma, Primary Open Angle

Summary: glaucoma represents a group of conditions that cause damage to the optic nerve and can lead to irreversible vision loss. current treatments are aimed at lowering intraocular pressure while minimizing medication side effects. lumify™ (brimonidine tartrate ophthalmic solution 0.025%) is an fda-approved medication for alleviating eye redness, a common side effect of glaucoma medications. the purpose of this study is to evaluate the effect of lumify™ on eye redness, intraocular pressure, and eyelid position in patients with glaucoma who are already using the brimonidine 0.1%, 0.15% or 0.2% eye drops.


Eligibility criteria:
inclusion criteria: * age \> 18 years * diagnosis of primary open angle glaucoma * willing and able to give informed consent * current and greater than 6 weeks of brimonidine 0.2%, 0.15% or 0.1% use exclusion criteria: * pregnancy * prisoners * known allergy or sensitivities to brimonidine * no surgery within the past 6 months * no history of lid surgery or botox * any other significant ophthalmologic disorder or condition with relevant effect on ocular redness, iop, or eyelid position as evaluated by principal investigator * inability to sit comfortably for 30 minutes * prior use of eye whiteners (eg, vasoconstrictors), decongestants, antihistamines, or phenylephrine dilating drops within 1 week of study
dopamine reuptake inhibitors of cocaine abuse - 1

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to evaluate dopamine reuptake inhibitors for cocaine abuse.


Eligibility criteria:
inclusion criteria: - exclusion criteria: -

Keywords: cocaine-related disorders
a preliminary comparison of the blood levels of medications in obese subjects compared to post-gastric bypass subjects

Conditions: Obesity

Summary: the purpose of this study is to determine the difference, if any, in the area under the sertraline plasma level time curve (auc) between patients who are nine to fifteen months post roux-en-y bariatric surgery and control subjects matched for body mass index (bmi), age and gender.

secondary objectives include the determination of changes in mean cpmax, time to cpmax and volume of distribution between the two groups. also, assessment of subject tolerance of sertraline utilizing the uku side effect rating scale.

Eligibility criteria:
inclusion criteria: * male or female subjects between the ages of 18 and 60 years. * subjects must be of good general health by history and physical exam. * five subjects 9 to 15 months past bariatric surgery (roux-en-y procedure), no bmi requirement. * five subjects matched for body mass index, age and sex to the post bariatric surgery group. * no contraindications to receiving a single dose of 100 mg of sertraline. * women of child bearing potential must be practicing an accepted method of birth control (barrier method or oral contraception) and have a negative pregnancy test at baseline. exclusion criteria: * allergy to sertraline or any of its constituents. * candidates currently receiving sertraline or any other antidepressant. * candidates currently receiving a medication that interacts with sertraline (zoloft) * candidates who are poor metabolizers for the cyp2d6 and/or 2c19 enzymes. * candidates experiencing clinically significant, unstable neurological, hepatic, renal or cardiovascular disease. * candidates currently or with a past history of meeting dsm-iv diagnostic criteria for schizophrenia, schizoaffective disorder, bipolar disorder. * candidates who have participated in an investigational drug study in past 30 days. * candidates who meet dsm-iv diagnostic criteria for drug/alcohol abuse or dependency or who have a history of drug/alcohol abuse or dependency. * candidates who are pregnant or nursing at time of study.

Keywords: gastric bypass sertraline pharmacokinetics
development of niv score of capsule endoscopy in patients with crohn's (cecdaiic)

Conditions: Crohn's Disease

Summary: hypothesis this study is designed as an integral part of the development of a new ce score for crohn's disease. the sb (small bowel) cd (crohn's disease)niv score (cecdai) is an established and validated cd score for sb involvement. in order to expand this score to the colon, this study will aim to develop the colonic score and later on will be combined with the already established sb score in order to achieve a full ce gut score for crohn's disease proposed design this is a retrospective study in which up to 30 videos of colon crohn's disease subjects who have undergone the colon 2 ce procedure will be evaluated. these cases will have evidence of large and / or small bowel crohn's disease the chosen videos will be marked for cd lesions by the site the de-identified marked videos will be scored by 4 independent experienced endoscopists, blinded to the results of the standard workup procedures, according to the colonic and cecdaiic new scores


Eligibility criteria:
inclusion criteria: * videos of colon crohn's disease subjects who have undergone the colon 2 ce procedure will be included. exclusion criteria: -
the effect of exercise on post-traumatic stress disorder and sleep quality in individuals affected by the 2023 kahramanmaraş earthquakes

Conditions: Earthquake; Stress Disorders, Post-Traumatic

Summary: natural disasters can have adverse impacts on both physical and mental health. post-traumatic stress disorder (ptsd) and sleep disorders are among the most common problems seen after natural disasters. exercise may represent a safe, cost-effective, accessible, non-pharmacological method for treating ptsd and sleep problems. the aim of this study was to investigate the effect of exercise interventions on ptsd and sleep quality in young individuals affected by the 2023 kahramanmaraş earthquakes in türkiye.


Eligibility criteria:
inclusion criteria: * age 18-30 * being directly affected by the earthquake in mardin * providing voluntary consent to participating in the study exclusion criteria: * involvement in an existing active regular exercise program * the presence a physical problem capable of preventing exercise * the presence of severe psychiatric disorders or cognitive and/or perceptual problems * regular use of sedative or neuropsychiatric drugs * active alcohol or drug addiction * missing assessment parameters * failure to participate in the intervention programs, or not continuing wıth the study

Keywords: natural disaster earthquake exercise post-traumatic stress disorder sleep quality physiotherapy and rehabilitation
the flipped classroom approach in ophthalmology residency

Conditions: Educational Problems

Summary: this study aims to evaluate the flipped classroom approach compared to the traditional classroom approach in teaching horizontal strabismus in ophthalmology residency didactics.

ophthalmology residents (post-graduate years 2-4) from 11 institutions were invited to participate. participating residents were taught esotropia and exotropia topics sequentially, randomized by order and classroom style (flipped classroom vs. traditional lecture) one to three weeks apart. participants were assigned a pre-class video lecture prior to the flipped classroom in-class case-based activity. the traditional classroom included a preparatory reading assignment and an in-person lecture delivered by the same instructor. participants completed three identical 5-question content assessments (pre-test, post-test, and 3-month retention) and opinion surveys following each classroom.

Eligibility criteria:
inclusion criteria: * ophthalmology residents of all levels (pgy2-pgy4) from 11 residency programs were invited to participate in this study exclusion criteria: * those who did not complete both classroom styles were excluded from the survey data * those who lost their study-ids were excluded from the results analysis

Keywords: flipped classroom
gallex 1 - long term extension study in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: this is a 107-week open-label, multi-center long-term extension study from gallant studies 2/22, 5, 7, 8 and 14 to monitor the safety and tolerability of oral tesaglitazar 1 mg in patients with type 2 diabetes during up to 104 weeks of treatment. the total duration, including treatment and follow-up, is 107 weeks.


Eligibility criteria:
inclusion criteria: * provision of a written informed consent * men or women who are \>=18 years of age * female patients: postmenopausal, hysterectomized, or if of childbearing potential, using a reliable method of birth control * completed the last two visits of randomized treatment period in gallant 2/22, 5, 7, 8 or 14 studies. exclusion criteria: * type 1 diabetes * new york heart association heart failure class iii or iv * treatment with chronic insulin * history of hypersensitivity or intolerance to any peroxisome proliferator-activated receptor agonist (like actos or avandia), fenofibrate, metformin or 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor (statin) * history of drug-induced myopathy or drug-induced creatine kinase elevation, liver enzyme elevations, neutropenia (low white blood cells) * creatinine levels above twice the normal range * creatine kinase above 3 times the upper limit of normal * previous enrollment in this long-term extension study * any clinically significant abnormality identified on physical examination, laboratory tests or electrocardiogram, which in the judgment of the investigator would compromise the patient's safety or successful participation in the clinical study
impact of the covid-19 pandemic on central precocious puberty: a retrospective cohort study from turkey

Conditions: COVID19- Infection with SARS-CoV-2 Virus

Summary: objective: this study investigates the clinical and demographic characteristics of girls diagnosed with central precocious puberty (cpp) in the pre-pandemic and pandemic periods to assess potential changes during the covid-19 pandemic.

methods: a retrospective cohort study was conducted on patients admitted to the pediatric endocrinology departments of two centers in turkey. girls treated with gnrh analogs between march 2018 and 2022 were categorized into two groups: the pre-pandemic group (2018-2020) and the pandemic group (2020-2022). clinical, anthropometric, and hormonal data were analyzed. patients with organic lesions, genetic conditions, or medications affecting puberty were excluded.

Eligibility criteria:
inclusion criteria (who can participate?) girls: tanner stage ≥2 before age 8 peak lh \> on gnrh analog test, basal lh \>0,3 patients with organic lesions (e.g., hypothalamo-pituitary tumors), congenital malformations, oncological diseases, neurosurgical or genetic disorders, or medications affecting puberty were excluded from the study

Keywords: central precocious puberty, covid-19 pandemic, gnrh analogs, pediatric endocrinology, lifestyle changes