Kornimate/medical-research-clean huggingface dataset:
areas of brain responsible for understanding american sign language

Conditions: Brain Mapping; Deafness; Healthy

Summary: the human brain is made up of two halves called hemispheres. each half of the brain is responsible for processing different kinds of information. previous neuroimaging studies have shown that both the right and left hemispheres are involved when processing information given in american sign language (asl). however, the study also showed that when processing spoken language, the left hemisphere was mostly involved. researchers would like to find out more about how the brain processes american sign language (asl). this study is designed to determine if the right hemisphere is necessary for normal understanding of asl.

the purpose of this protocol is to determine if the right hemisphere activation associated with perception of american sign language (asl) in deaf subjects and in normal hearing individuals raised by deaf parents (who learned asl before written english) is necessary for appropriate understanding of asl.

Eligibility criteria:
subject age between 18 and 65 years. adult hearing offsprings of deaf parents. congenitally deaf individuals. intact hearing volunteers. no subjects with personal or family history of seizures or other neurological or demyelinating disorders. no pregnant women tested after urine pregnancy test. no subjects with severe coronary disease. no subjects with metal in the cranium except mouth. no subjects with intracardiac lines and implanted medication pumps. no subjects with increased intracranial pressure as evaluated by clinical means. no subjects with cardiac pacemakers. no subjects with an intake of neuroleptics.

Keywords: deafness hemisphere dominance language plasticity speech rtms
a modified omental patch work decreases pancreatic fistula after lpd

Conditions: Omental Patch; Laparoscopic Pancreaticoduodenectomy; Pancreatic Fistula

Summary: pancreaticoduodenecotmy(pd) is considered as the standard procedure for peri-amplullary or pancreatic head tumors. laparoscopic pancreaticoduodenctomy(lpd) has been reported with minimal invasive advantages, such as small incision, less blood loss, less pain, et al. further, some trials showed lpd got less morbidity and shorter length of stay. pancreatic fistula is the major complication for pancreaticodupdenectomy and associated with numerous serious complications, suffering reoperation or sometimes death. the reported rate was 10% to 55%. a lot of modified procedure have been proposed to reduce pancreatic fistula. omental flaps around anastomosis have been used to prevent post pancreaticoduodenectomy fistula or hemorrhage. however, the outcomes are controversy. a modified omental patch work has been used during lpd and the initial outcomes are good. this is a pilot study to evaluate the function of the modified omental patch work on decreasing the pancreatic fistula.


Eligibility criteria:
inclusion criteria: 1. . disease of periampullary or pancreatic head tumor 2. . age: 18 years or older 3. distant metastases are not diagnosed preoperatively. 4. . patients who can provide written informed consent exclusion criteria: 1. . patients with severe organ disease such as cardiac disease,respiratory illness 2. . patients with extended lpd or vessels reconstruction 3. patients with conversion to laparotomy 4. . patients with pregnancy
community-based health education programs for the early detection of, and vaccination against, covid-19 and the adoption of self-protective measures of hong kong residents

Conditions: COVID-19

Summary: this study evaluates the community-based health education program in improving early testing for covid-19, increasing vaccination acceptability and enhancing emergency preparedness and self-protection measures against covid-19 in hk. we established a partnership with several local community stakeholders and they will be responsible for recruiting participants and implementing educational programs. half of the community collaborators will receive the core intervention package, and use it as education material. the other half will be encouraged to self-collect and send health information to the participants.

this health education program is based on a community-based participants research (cbpr) approach, which is a partnership approach that equitably involves community members and researchers in all aspects of the research process. given the different cultural, professional or living background of hong kong residents, we think this simple, flexible and sustainable approach will effectively mitigate the covid-19 risk in hk society, an academic-community collaboration platform with several nongovernmental organizations (ngos), companies and schools will be established before this study. they will work together to recruit participants, design and implement a series of educational programs aimed at controlling the spread of covid-19 in the community.

Eligibility criteria:
for participants recruited by ngos and companies, the inclusion criteria will be: * hk resident aged 18 years or above; * agreement to participate in the study and provide written informed consent. the exclusion criteria will be: * cognitive impairment that inhibits communication with the investigators; * inability or unwillingness to provide written informed consent. for participants recruited by schools, the inclusion criteria will be: * hk students aged 12 to 18 years and their parents. the exclusion criteria will be: * cannot provide written informed consent (or assent for the younger students).

Keywords: cbpr health education vaccination rate early-testing self-protection hong kong residents
pain modality treatment after hemorrhoidectomy

Conditions: Pain, Acute; Pain, Procedural

Summary: hemorrhoidectomy is one of the operations that causes the greatest intensity of pain. treatment of postoperative pain is essential for the well-being of the patient. long-term use of opioids and different drugs can have unintended consequences. the objective is to corroborate which pain treatment modality is better in patients after hemorrhoidectomy.

patients who have undergone a hemorrhoidectomy are included in the study, the pain treatment modality is conceived by the treating surgeon or anesthesiologist. the first modality is to administer pain killers on-demand depending on visual analog scales of pain and the second modality to give pain killers on determined hours.

Eligibility criteria:
inclusion criteria: elective surgery for hemorrhoids exclusion criteria: mental retardation incapacitated patient under 18 years old

Keywords: pain killers
case-control study of sleep disorders in children with cystic fibrosis

Conditions: Cystic Fibrosis; Sleep Disorder

Summary: our primary purpose is to compare the prevalence of sleep disorders in children aged 6 to 17 with cystic fibrosis versus controls with a sleep disorder screening score, the sdsc. our hypothesis is that patients aged 6 to 17 with cystic fibrosis have a higher prevalence of sleep disturbances than the general population of the same age group. our secondary hypothesis is that these sleep disorders are mixed and that there are non-respiratory causes, sometimes modifiable by simple non-medical treatment and that's why our secondary purpose is to identify the responsible factors, in particular non-respiratory factors in the 2 groups and to compare them.


Eligibility criteria:
inclusion criteria for the case group : * cystic fibrosis followed at the pediatric (centre de ressources et de compétences de la mucoviscidose) in strasbourg * aged from 6 to 17 years old * non hospitalized * able to read and understand french language * accompanied by at least one of his parents inclusion criteria for the control group : * emergency surgical consultation * aged from 6 to 17 years old * non hospitalized * able to read and understand french langage * accompanied by at least one of his parents exclusion criteria: * children under 6 years old * children over 17 years old * children and parents who don't understand or can't read french language * hospitalized children * children unaccompanied by their parents

Keywords: children case control study
a long-term safety study of asoprisnil in the treatment of uterine fibroids.

Conditions: Leiomyoma

Summary: this study was designed to determine the long-term safety of asoprisnil 10 mg in women with one or more uterine fibroids after an initial 12 weeks in study m99-144.

no medical therapy is currently available for the long-term treatment of uterine fibroids. the objective of this study is to determine the long-term safety of asoprisnil 10 mg daily for 6 months, after an initial 12 weeks in study m99-144, in women with one or more uterine fibroids, confirmed by ultrasound in study m99-144. the safety endpoints for this study will be based on ultrasound and endometrial biopsy results, adverse events, and any changes from baseline laboratory values and vital signs.

Eligibility criteria:
inclusion criteria: * completed dosing and day 84 procedures at sites in study m99-144 * no interruption of dosing * otherwise continued good health exclusion criteria: * any abnormal lab result the study-doctor considers significant * history of severe reaction to or current use of hormone therapy * history of alcohol or drug abuse

Keywords: fibroid uterus leiomyoma uterine fibroids asoprisnil
the economic impact of the pancreatography in the endoscopic treatment of pancreatic pseudocysts

Conditions: Pseudocyst Pancreas; Pancreatic Duct Disorder

Summary: pancreatic pseudocysts (pp) present as a complication that occurs in 5-15% of acute pancreatitis and 26-40% of chronic pancreatitis (1-3). to date the endoscopic drainage with endoscopic ultrasound (eus) has replace the surgical treatment due to the similar success and complication rate but with a lower cost and short hospital stay (4-6). regarding recurrence, it is important to know the anatomy of the main pancreatic duct (mpd). for this purpose, the endoscopic retrograde pancreatography (erp) has been describe as a useful tool. in fact, many authors perform it before the endoscopic drainage while others wait several weeks after the drainage (7-9) with similar technical success (5,8). however, there are no studies that compare the technical difficulty and the total cost between these two approaches.

methods: random control trial between two groups. group 1 the erp will be performed the same day of the endoscopic drainage of pp. group 2 the erp will be performed 6 weeks after the endoscopic drainage of pp. each erp will be performed by an expert in erp in patients who fulfilled the atlanta criteria for pp. the patients will be enrolled and informed consent will be explained and signed. in those patients who erp fails, a second attempt will be performed 6 weeks after the endoscopic drainage of pp (group 1) or a magnetic resonance cholangiopancreatography will be performed (group 2).

Eligibility criteria:
inclusion criteria: 1. pancreatic pseudocyst that fulfilled the atlanta classification 2. symptomatic pancreatic pseudocyst 3. informed consent obtained exclusion criteria: 1. patient unwilling to participate 2. absence of duration time of the pancreatography procedure in the record 3. absence of the number of weeks between the drainage and the pancreatography

Keywords: pancreatic pseudocyst
rifampin combination therapy versus monotherapy in early staphylococcal infections after total hip and knee arthroplasty

Conditions: Prosthesis-related Infections; Staphylococcal Infections

Summary: the number of patients requiring joint replacement is increasing due to its success in restoring function and pain relief, and the growing population of the elderly. one of the most serious complications of arthroplasty is joint prosthesis infection. due to the absence of prospective, randomized, controlled studies, there is no consensus concerning diagnosis and treatment of prosthetic joint infections. the main objective of this trial is to evaluate the clinical efficacy of rifampin combination therapy versus monotherapy using cloxacillin or vancomycin in early staphylococcal infections after total hip and knee arthroplasty.

the study is a controlled randomized multicentre trial with 8 participating centres in norway. we will include patients with the diagnosis of early infections (within 4 weeks post operatively)after hip or knee replacement. patients with clinical signs of infection are scheduled for a standardized soft tissue revision. diagnosis of staphylococci must be established by arthrocentesis or at surgical revision, and must grow in at least 2/8 cultures.the patients will randomly be assigned to antimicrobial therapy with or without rifampin by a randomization programme. antibiotics will be given for 6 weeks. two years follow-up. the study end points are final follow-up visit after two years or relapse of infection.

Eligibility criteria:
inclusion criteria: * prosthetic joint infections category 2 or 3 (early post.op infections within 4 weeks). * diagnosis of staphylococci. * clinically and radiographically stable implants kept in place after revision. exclusion criteria: * infection with other microorganisms than staphylococci. * less than 2 years of expected survival. * predictable inability to comply with the treatment and/or follow-up visits. * contraindication to the use of study medication including acute or chronic liver disease. * lack of written consent. * fertile women. * patients taking less than 80% of the study medication.
safety and efficacy study of gs-5806 in healthy volunteers infected with respiratory syncytial virus (rsv)

Conditions: Respiratory Syncytial Virus Infections

Summary: this study is to evaluate the antiviral effect of gs-5806 in healthy adults infected with a strain of respiratory syncytial virus.


Eligibility criteria:
inclusion criteria: * healthy male or female * between 18 to 45 years old * body mass index of 18 to 33 kg/m2 exclusion criteria: * acute or chronic medical illness * positive for human immunodeficiency virus, hepatitis b or c * nose or nasopharynx abnormalities * abnormal lung function

Keywords: respiratory syncytial virus infections rsv
engaging black men in colorectal cancer screening

Conditions: Colorectal Cancer; CRC; Behavior

Summary: to determine the unmet needs, attitudes, barriers and facilitators of african american (aa)/ black men use of colorectal cancer screening and describe how community leaders such as barbers may act as community champions to educate and facilitate screening participation.


Eligibility criteria:
inclusion criteria: * adult men * identify as black or african american * work or live in petersburg, va or surrounding counties * eligible for colorectal cancer (crc) screening at time of study enrollment exclusion criteria: * inability to speak or read english * currently up-to-date with crc screening

Keywords: colorectal screening behaviors
mv-140 efficacy in recurrent urinary tract infections in a cohort of portuguese adult patients

Conditions: Urinary Tract Infections

Summary: we will access the efficacy of mv-140 immunotherapy in the prevention of recurrent urinary tract infections in a cohort of portuguese patients.

urinary tract infections represent a highly frequent and debilitating disease, responsible for an extensive use of antibiotics for treatment and prophylaxis. non-antibiotic therapies, such as oral vaccines, have been developed, in order to avoid antibiotic use. mv-140 is a sublingual vaccine comprised of 4 inactivated bacteria - e. coli, k. pneumoniae, e. faecalis and proteus vulgaris. it is approved for the prevention of recurrent utis, with promising results in the few published results to date. the efficacy of this tool in the portuguese population is, however, still unknown. since the prevalence of pathogens responsible for infections and overall antibiotic use are highly variable worldwide, the results of studies conducted so far are not directly applicable in other regions. therefore, we designed the present study which aims at assessing the efficacy of immunotherapy with mv-140 in the portuguese population. it is a prospective observational study, in which patients will be asked to report their condition before and 1 year after therapy.

Eligibility criteria:
inclusion criteria: * at least 3 positive urine culture utis in the preceding 12 months * ability to understand and fill the informed consent exclusion criteria: i. history of genitourinary tumours ii. urinary lithiasis iii. immunodeficiency iv. pregnancy v. simultaneous use of any other urinary tract prevention vaccines or prophylactic antibiotics

Keywords: urinary tract infections immunotherapy mv-140
stepped preventive care to reduce the impact of acute pediatric injury

Conditions: Stress Disorders, Posttraumatic

Summary: this study will evaluate the impact of a brief psychosocial intervention delivered to children or adolescents who are hospitalized for an unintentional injury. the intervention is designed to promote psychological recovery and enhance functional outcomes after injury. the study will also provide preliminary data concerning cost-effectiveness of the intervention. the core study hypotheses are that children receiving the intervention will (1) have lower severity of post-traumatic stress disorder (ptsd) and depression symptoms at follow-up; (2) show greater adherence to discharge instructions and better health-related quality of life at follow-up, and (3) have higher rates of attendance at scheduled follow-up appointments and lower rates of emergency room utilization and re-hospitalization in the 6 months post-injury, compared to those receiving usual care.

the purpose of this study is to examine the effectiveness of a stepped care model for prevention of psychosocial distress (especially posttraumatic stress) after injury. the model includes screening for risk, standard follow-up with those at risk, and additional evidence-based interventions matched to individual need. the study will evaluate the impact of the intervention on psychosocial outcomes (ptsd and depression symptoms); as well as health outcomes (adherence to discharge instructions, health-related quality of life), and will provide preliminary data to inform cost-effectiveness analyses by describing the costs of providing the intervention and examining its impact on subsequent health service utilization. study design: 180 children at risk for persistent psychosocial distress post-injury, based on a screening assessment, will be randomized to the stepped preventive care intervention or usual care. an additional comparison group of 90 low risk children will also receive usual care and be followed for assessment.

Eligibility criteria:
inclusion criteria: * age 8 to 17 * admitted to hospital for treatment of unintentional injury * sufficient english fluency to participate in an interview * family has access to a telephone (for telephone follow-up contacts) exclusion criteria: * child's medical status or cognitive functioning precludes participating in an interview * child has moderate to severe head injury, defined as glasgow coma score (gcs) \<= 12 * child's injury involved family violence or abuse (physical or sexual) * no parent or guardian available to consent
can massage during one year improve health in health-care providers working in hospital

Conditions: Massage Therapy; Health-care Workers; Quality of Life; Psychological Distress

Summary: the overall aim of this pilot study is to investigate the effect, "feasibility" and experiences of regular massage over 12 months on the mental and physical health of healthcare professionals, as well as the frequency of layoffs, sick leave and reported patient safety risk cases, as well as health economics

a pilot and "feasibility" study with pre-post design. 50 health care professionals from the medical clinic, vrinnevi hospital in norrköping are included. the participants perform 10 30 minute sessions of classic swedish massage during 12 months by a certified masseur. mental and physical health data is collected using questionnaires, blood and body weight. data on layoffs, sick leave and patient safety risks are taken from the hospital's data register. data regarding the participants' experience of receiving massages is collected during interviews.

Eligibility criteria:
inclusion criteria: working at least for 50 % of fulltime main task working with patient care in the hospital ward exclusion criteria: -
tofacitinib for the treatment of alopecia areata and its variants

Conditions: Alopecia Areata; Alopecia Totalis; Alopecia Universalis

Summary: the purpose of this study is to investigate the ability of tofacitinib citrate, a janus kinase inhibitor, to generate hair regrowth in patients with moderate to severe alopecia areata and its variants.

this study is an open-label pilot study. participants will be treated with oral tofacitinib for 3 months.

Eligibility criteria:
inclusion criteria: * age \>= 18 years old * diagnosis of alopecia areata with \>50% scalp involvement, alopecia totalis, or alopecia universalis * hair loss present for at least 6 months * no treatment for alopecia areata in past 2 months * no evidence of hair regrowth * females of childbearing potential must use birth control while taking the medication and there must be a negative pregnancy test documented prior to starting the medication * fluent in spoken and written english exclusion criteria: * age \<18 years old * patients have received treatment known to affect alopecia areata within 2 months of enrolling in the study * patients with a history of malignancy (except history of successfully treated basal cell or squamous cell carcinoma of the skin) * patients known to be hiv or hepatitis b or c positive * patients with positive tuberculin skin test or positive quantiferon tb test * patients with leukopenia or anemia * patients with renal or hepatic impairment * patients with peptic ulcer disease * patients taking immunosuppressive medications, including but not limited to prednisone, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus, cyclosporine, or tnh-alpha inhibitors * women of childbearing potential who are unable or unwilling to use birth control while taking the medication * women who are pregnant or nursing