Kornimate/medical-research-clean huggingface dataset:
fecal microbiota transplantation in postoperative crohn's disease

Conditions: Crohn Disease

Summary: this pilot study aims to detect possible trends or signals suggesting efficacy of fmt on prevention of delay of por, to determine the safety of fmt in post operative cd, and asses if a full randomised controlled trial is feasible in this setting. with microbiota analysis we aim to assess if changes in gut microbiota are related to disease course of cd after operation.


Eligibility criteria:
inclusion criteria: * over 18 years * able to provide written consent * stricturing and/or fistulizing crohn's disease needing ileocecal or ileal resection exclusion criteria: * pregnancy * active infection, abscess or fistula at the time of the first colonoscopy * life expectancy \<1 year * unable to provide written consent * use on antibiotics or probiotics at the time of first colonoscopy

Keywords: fecal microbiota transplantation
evaluation of biliary reflux after mini-gastric bypass with using the biliary reflux index

Conditions: Ulcer, Gastric; Bile Reflux

Summary: mgb is considered to be the best alternative to roux-en-y gastric bypass (rygb) due to the shorter operation time and fewer possible complications. the purpose of this study was to determine biliary reflux in patients undergoing mgb/oagb with a hand-sewn gastroenteroanastomosis, and mgb/oagb with a stapler gastroenteroanastomosis.


Eligibility criteria:
inclusion criteria: * morbid obesity * bmi above 35 kg/m2 with obesity related comorbidity * bmi above 40 kg/m2 * undergoing mgb/oagb * no bile reflux during preoperative period exclusion criteria: * revisional operations * therapy-resistant bile reflux during preoperative period * history of bariatric surgery
safety of mesh used repairs in emergency abdominal wall hernias. prospective randomized multicenter trial

Conditions: Hernia

Summary: repairing of emergency (strangulated) abdominal wall hernias with mesh may cause infective complications.

repairing of emergency (strangulated) abdominal wall hernias with mesh is controversary. strangulated abdominal hernias are not clean surgical wounds so applying prostetic materials such as meshes are problematic. using of prostetic materials in un-clean wounds (clean contaminated, contaminated and dirty) is not proposed. but in surgical practice meshed surgical repair techniques are using largeley. in this multicenter study we try to find the answer for emergency hernia repairs meshed or not.

Eligibility criteria:
inclusion criteria: 1. older than 16 years old, 2. strangulated abdominal wall hernia 3. no any contrindications to operation exclusion criteria: 1. younger than 16 years old, 2. non-strangulated abdominal wall hernis 3. any causes of contrindications to operation

Keywords: hernia, abdominal, strangulation, emergency, wall
simulated amniotic fluid solution in neonates recovering from git surgeries

Conditions: Necrotizing Enterocolitis

Summary: amniotic fluid plays a significant role in fetal gut maturation and development. the human fetus swallows over 200 ml of amniotic fluid per kilogram of weight each day and such swallowing is essential for normal small bowel development.growth factors found in the amniotic fluid have been shown to promote proliferation of fetal intestinal cells. as feeding intolerance is a common problem among neonates recovering from surgery for congenital bowel abnormalities, the investigators will study the role of enteral administration of simulated amniotic fluid solution in prevention of feeding intolerance and nec in neonates recovering from git surgeries.

neonates with congenital git anomalies will participate after being operated. participants will be followed for the duration of hospital stay until discharge or death.

Eligibility criteria:
inclusion criteria: * neonates with operable congenital bowel abnormalities exclusion criteria: * critically ill babies. * presence of any contraindications to enteral feeding

Keywords: feeding intolerance simulated amniotic fluid like solution necrotizing enterocolitis
evaluating an online adjunctive support following intensive services (oasis) strategy for youth with selective mutism

Conditions: Selective Mutism

Summary: this study sought to evaluate an innovative post-acute continuation/transition planning treatment strategy that leveraged an in-person intensive treatment followed by online, videoconferencing-based "booster" sessions for youth with selective mutism (sm). twenty children between the ages of 4 and 10 and their caregivers were scheduled to participate in an in-person intensive group behavioral treatment (igbt) for sm and subsequently randomized to receive either (a) six, biweekly, hour-long, videoconferencing-delivered booster sessions or (b) no additional treatment for 12 weeks. due to covid-19-related physical distancing restrictions, the study team was unable to provide in-person services. thus, the clinical trial was converted to an open-trial design focused on evaluating remote treatment options (i.e., remotely delivered caregiver training sessions and/or a remotely delivered igbt) for these families. all families retained in the study have or will participate(d) in assessments at the following time points: intake (i.e., 4-5 months prior to the remote igbt); baseline (i.e., 1 month prior to the igbt), post-igbt (i.e., 2 weeks following the igbt), and school year follow up (i.e., 16 weeks following the igbt).


Eligibility criteria:
inclusion criteria: * child between the ages of 4-10 years, and his or her caregiver(s) * child meets dsm-5 criteria for selective mutism diagnosis * child speaks english fluently exclusion criteria: * child is identified as having any psychiatric condition significantly more impairing than selective mutism that requires alternate treatment * the child is nonverbal with all caregivers
cabozantinib with pemetrexed in advanced non-small cell lung cancer, urothelial cancer and malignant mesothelioma

Conditions: Non Small Cell Lung Cancer; Non-squamous Non-small-cell Lung Cancer; Urothelial Carcinoma; Malignant Mesothelioma

Summary: this study will combine cabozantinib with pemetrexed to treat patients with non-small cell lung cancer, urothelial cancer and advanced malignant mesothelioma. this study will test the safety of both drugs used together and see what effect (good or bad) it has no participants and their cancer.


Eligibility criteria:
inclusion criteria: * locally advanced nsclc, urothelial cancer or malignant mesothelioma. * 18 years or older. * at least one prior chemotherapy before entering in this trial. * not pregnant or breastfeeding. exclusion criteria: * prior treatment with cabozantinib. * currently receiving cancer treatment (last dose 2 weeks prior to enrollment in study). * history of bleeding disorder/bleeding history within 12 weeks before first study treatment dose.
the effect of musıc on labor paın, anxıety and breastfeedıng success

Conditions: Labor Pain; Anxiety; Breast Feeding; Post Operative Pain

Summary: the aim of this study is to examine the effects of music played to primiparous women who had a cesarean section on pain, state anxiety and breastfeeding success.


Eligibility criteria:
inclusion criteria: * caesarean section * live birth exclusion criteria: * risky pregnancy * twin pregnancy * newborn with cleft palate, cleft lip
telmisartan 80mg+hydrochlorothiazide (hctz) 25 mg in hypertension: an observational study

Conditions: Hypertension

Summary: it is a national, retrospective , observational study in hypertensive patients treated for at least 8 weeks with the fixed dose combination of telmisartan 80 mg and hydrochlorothiazide 25 mg. the primary objective is to assess the control rate (systolic and diastolic blood pressure). key secondary objectives are to assess the blood pressure reduction after at least 8 weeks of treatment, describe the population treated with this new fixed dose combination


Eligibility criteria:
inclusion criteria: * hypertensives * treated for at least 8 weeks with the fixed dose combination of telmisartan 80 mg and hydrochlorothiazide 25 mg exclusion criteria: - treated with the combination less than 8 weeks
normal values for esophageal high resolution manometry in an advanced protocol including liquid swallows and a solid test meal

Conditions: Healthy

Summary: normal values for measurements of high resolution manometry in a protocol which includes isolated liquid swallows in upright and recumbent position, free drinking of water, a solid test meal and a postprandial observational period will be determined.

the investigators will recruit healthy volunteers and ask for study participation. after providing informed consent, participants will be questioned using standardized questionnaires assessing symptoms of reflux, dysphagia, gastrointestinal symptom burden and depression. participants will be tested using our advanced protocol for high resolution esophageal manometry. this protocol includes individual liquid swallows, free drinking of water, a standardized test meal (200g rice) and a postprandial observational period. normal values for liquid and solid swallows will be determined.

Eligibility criteria:
inclusion criteria: * healthy volunteers without gastrointestinal co-morbidity exclusion criteria: * inability or unwillingness to provide informed consent * any relevant current or past gastrointestinal morbidity (including diseases relevant previous surgery). * relevant gastrointestinal symptoms * relevant medication (as specified below) within the last 4 weeks * age below 18 years

Keywords: dysphagia reflux symptoms retrosternal pain
patient experiences with the covid-19 vaccination after breast cancer treatment

Conditions: Breast Cancer Related Lymphedema; Covid19

Summary: this study aims to elicit patient experiences, choices, and side effects associated with the covid-19 vaccine after breast cancer surgery. lymph node swelling is a known and common side effect of both the moderna and pfizer covid-19 vaccines. this is the body's normal reaction to the vaccine. it is worrisome that lymph node swelling after the vaccine mimics that found in breast cancer which has spread to the lymph nodes. this side effect will cause worry and anxiety amongst patients as a result. for patients who have had lymph node removal (axillary lymph node dissection or sentinel lymph node biopsy) and are at risk of lymphedema, the investigators are concerned that the lymph node swelling may tax the lymphatic system and incite lymphedema in those at risk or worsen it in those with bcrl. fear of lymphedema is high in this population and the investigators need to better understand what risk, if any, lymph node swelling after the covid-19 vaccine imparts to bcrl risk.

* hypothesis 1: patients will choose to receive the vaccine on the arm contralateral to axillary lymph node removal, or in the lower extremity if they have had bilateral axillary lymph node removal * hypothesis 2: patients with a history of breast cancer will experience axillary lymph node swelling after receiving the covid-19 vaccine at the same rate as the general population * hypothesis 3: patients with axillary surgery who develop lymph nodes swelling in the ipsilateral side might be at increased risk of developing lymphedema

Eligibility criteria:
inclusion criteria: * female patients who are * ≥18 years of age and have a * history of breast cancer for the mgh site, patients must have * received some breast cancer treatment at mgh or its affiliates * received perometry measurements to measure arm volume at mgh exclusion criteria: * none

Keywords: breast cancer vaccination lymphadenopathy
study to assess efficacy and safety of lanreotide autogel 120 mg in treatment of clinical symptoms associated with inoperable malignant intestinal obstruction

Conditions: Intestinal Obstruction

Summary: to assess the efficacy of lanreotide autogel 120 mg for the relief of vomiting due to inoperable malignant intestinal obstruction in patients without nasogastric tube (ngt) and to assess the efficacy of lanreotide autogel 120 mg on removal of nasogastric tube without the recurrence of vomiting in patients with an inoperable malignant intestinal obstruction with a nasogastric tube.


Eligibility criteria:
inclusion criteria: * written informed consent before any study related procedure * male and female patients age 18 years or older at time of enrollment * diagnosis of intestinal obstruction of malignant origin * in case of peritoneal carcinomatosis, confirmation by ct or mri scan within the 3 months preceding the inclusion in the study * confirmed as inoperable after surgical advice * patient with a nasogastric tube or presenting with 3 or more episodes of vomiting / 24h in the last 48 hours * estimated life expectancy 1 month or more exclusion criteria: * operable obstruction or subobstruction * bowel obstruction due to a non-malignant cause * signs of bowel perforation * prior treatment with somatostatin or any other analogue within the previous 60 days * a known hypersensitivity to any of the study treatments or related compounds * previous participation in this study * is likely to require treatment during the study with drugs that are not permitted by the study protocol * has abnormal baseline findings, any other medical condition(s) or laboratory findings that, in the opinion of the investigator, might jeopardise the subject's safety
0.018 or 0.022 bracket slot system more effective in orthodontic treatment?

Conditions: Malocclusion

Summary: the purpose of this study is to compare the 0.018-inch and 0.022-inch bracket slot systems to determine which is more effective for orthodontic treatment .

background: edgewise fixed orthodontic appliances are available in two different brackets slot sizes (0.018-inch and 0.022-inch). both systems are used by clinicians worldwide with many orthodontists claiming clinical advantages and superiority of one system over the other. however, the scientific evidence supporting this area is scarce and weak. this leaves the clinician's choice of bracket slot system to be based mainly on empirical clinical preferences. aim: to compare the 0.018-inch and 0.022-inch conventional ligation pre-adjusted orthodontic bracket slot systems in terms of the effectiveness of treatment. methods/design: prospective, multi-centre randomised clinical trial, undertaken in the secondary care hospital environment in nhs (national health service) tayside in the united kingdom. two hundred and sixteen orthodontic patients will be recruited in three secondary care centres in nhs tayside, united kingdom. the participants will be randomly allocated to treatment with either the 0.018-inch or 0.022-inch bracket slot systems (n= 108 for each group) using victory conventional ligation pre-adjusted bracket systems (3m unitek, monrovia, california). baseline records and outcome data will be collected both during and at the end of orthodontic treatment and will be assessed as follows:. primary outcome measures: the duration of orthodontic treatment for the maxillary and mandibular arches. secondary outcome measures: the number of scheduled appointments for the maxillary and mandibular arches, occlusal outcome (peer assessment rating index), orthodontically induced inflammatory root resorption using periapical radiographs and the patient perception of wearing orthodontic appliances.

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo dual arch fixed appliance orthodontic treatment in any of the three trial centers will be invited to participate in this trial by the operator planning to conduct their orthodontic treatment. exclusion criteria: * patients who have undergone previous orthodontic treatment including fixed, removable and functional appliances. * patients less than 12 years old at the start of orthodontic treatment. * patients with orofacial clefting, severe hypodontia, and special needs patients. * patients undergoing orthognathic (jaw) surgery as part of their orthodontic treatment plan.

Keywords: orthodontic, bracket slot, effective, randomized, duration
diet, insulin sensitivity and the brain

Conditions: Obesity; Diabetes Mellitus Type 2

Summary: obesity and insulin resistance may be in part explained by an altered reward system with changes in the serotonin/dopamine system. these changes might be caused by changes in dietary habits, especially by an increased intake of liquid sugar and an increase in meal frequency. the investigators hypothesize that increasing meal frequency compared to increasing meal size and when consuming a hypercaloric high-sugar diet (hs) compared to a hypercaloric high-fat-high-sugar diet (hfhs) will result in a reduction in cerebral serotonin and dopamine transporters and in a more prominent increase in insulin resistance. in addition, the investigators hypothesize that the changes in insulin sensitivity will be independent of changes in abdominal (visceral) and liver fat and that changes in insulin sensitivity due to the dietary manipulation will co-occur with changes in insulin signaling pathways in peripheral fat and muscle tissue.

lean, healthy, young men will follow a hypercaloric hf- or hfhs diet for 6 weeks. before and after the dietary intervention, the investigators will perform a spect-scan for serotonin and dopamine transporters with the radioligand \[123i\]fp-cit, administered intravenously. the investigators will also perform a structural mri for localization. furthermore the investigators will perform a liver mrs and abdominal mri for liver fat- and abdominal visceral fat measurement. the investigators will also perform a euglycemic, hyperinsulinemic clamp to measure insulin sensitivity and muscle- and fat biopsies to examine changes in insulin signaling pathways and fat metabolism. after the hypercaloric diet subjects will follow a hypocaloric diet until their weight is back to baseline.

Eligibility criteria:
inclusion criteria: * bmi 19-26 kg/m2 * age 18-40 years old * male gender * caucasian * stable weight 3 months prior to start study participation exclusion criteria: * abnormal oral glucose tolerance test (ogtt) * lipid disorders, renal disorders, thyroid disorders, elevated liver enzymes * use of medication * use of alcohol \> 3/day * use of ecstasy, amphetamines or cocaine * smoking * history of eating disorder or psychiatric disorder * any medical condition, intensive sports ( \>3 times/week), shift work

Keywords: diet manipulation serotonin dopamine insulin sensitivity
study of the spread of covid-19 in saint petersburg, russia

Conditions: COVID19

Summary: seroprevalence study of covid-19 in saint petersburg, russia is a regional longitudinal cohort study aiming to evaluate the spread dynamics of the covid-19 disease in the population of saint petersburg. clinically asymptomatic adults are sampled from the population using random digit dialing and tested for the presence of sars-cov-2-specific antibodies in the blood serum. data collection and serial sampling of the same individuals spans four weeks and is conducted every two weeks in order to understand both the spread of the virus in the population.

at least 1 000 individuals, 18 years old and older, are randomly sampled using random digit dialing from the population of saint petersburg, russia. random sampling is performed by a survey company on the list of mobile phone numbers with designated geography prefixes of st. petersburg. the baseline questionnaire for computer-assisted telephone interview includes travel history, medical history, and socio-economic status of the respondents. sampled individuals are then invited to the clinic for blood sampling, their refusal to participate is recorded. collected blood samples are used for sars-cov-2-specific antibodies testing. data and sample collection spans four weeks and is conducted every two weeks. participants complete additional questionnaires in the clinic providing information on medical history, history of allergies, chronic disease, smoking, and medication taken regularly. contact tracing data and environmental conditions of the household are reсorded.

Eligibility criteria:
inclusion criteria: * individuals sampled from the population of saint petersburg, russia using random digit dialling. * subjects aged 18 and older of both genders. * asymptomatic at the time of blood draw. * written informed consent for a blood draw, sars-cov-2 antibody test, and data collection. exclusion criteria: * presence of fever or cough or respiratory distress at the time of blood test not attributable to other known chronic disease. * age under 18. * any health condition that may be a contraindication towards blood sampling in out-patient clinic. * residence in kolpinskiy, kurortniy, krasnoselsky, kronshtadtskiy, petrodvorcoviy, pushkinskiy districts of st. petersburg.

Keywords: seroprevalence covid-19 sars-cov-2
renal denervation in patients with refractory hypertension

Conditions: Hypertension

Summary: to investigate the clinical utility of renal denervation in the treatment of refractory hypertension.


Eligibility criteria:
inclusion criteria: * \>= 18 years of age * a systolic blood pressure of 160mmhg or more * receiving and adhering to full doses of at least three antihypertensive drugs * estimated glomerular filtration rate (egfr) of ≥45ml/min * agrees to have the study procedure(s) performed and additional procedures and evaluations * is competent and willing to provide written, informed consent to participate in this clinical study exclusion criteria: * hemodynamically or anatomically significant renal artery stenosis * has a history or prior renal artery angioplasty * has experienced mi, unstable angina pectoris, or cva within 6 months * has hemodynamically significant valvular heart disease * has type 1 diabetes * has an implantable cardioverter defibrillator (icd) or pacemaker, or any other metallic implant which is not compatible with magnetic resonance imaging (mri) * requires respiratory support * is pregnant, nursing, or planning to be pregnant * has known, unresolved history of drug use or alcohol dependency. * is currently enrolled in another investigational drug or device trial.
rescue carotid stenting in tandem occlusions: 4-year experience from a comprehensive stroke centre

Conditions: Acute Stroke; Ischemic Stroke, Acute

Summary: the rescue carotid stenting has recently been an additional treatment followed by mechanical thrombectomy in tandem occlusions of the anterior circulation. nevertheless, there were few data to date that support this beneficial treatment in asia. the investigators hypothesized that this treatment related to improvement of clinical outcomes after procedure.

the anterior circulation made commonly up 70-80% of all ischemic strokes. the mechanical thrombectomy is the gold treatment standard in acute ischemic stroke due to large vessel occlusion of anterior circulation. tandem occlusions are one of the acute lesions relating to the high poor clinical outcome rate. besides, tandem characteristic is a challenge to perform endovascular therapy and save procedural time in the restoration blood flow to the cerebral artery territory infarction. many studies demonstrated the roles of rescue carotid stenting with either proximal-to-distal or distal-to-proximal approach in the successful recanalization of tandem occlusions. however, few studies analyzed in detail this beneficial treatment in asia. therefore, the investigators conducted this study to assess whether rescue carotid stenting in the tandem occlusions to improve clinical outcomes at 3 months.

Eligibility criteria:
inclusion criteria: * age \> 18 years old * onset to treatment time \< 24 hours * nihss \> 5 * dwi-aspects ≥ 5 exclusion criteria: * premorbid mrs \> 2 * loss to follow-up after discharge

Keywords: tandem occlusions rescue carotid stenting anterior circulation