Kornimate/medical-research-clean huggingface dataset:
effects of swimming in the treatment of fibromyalgia

Conditions: Fibromyalgia

Summary: the recent scientific evidence shows that fm patients improve exercise capacity, symptoms and quality of life with the holding of regular exercise, especially aerobic exercise. swimming is an aerobic workout of low impact, but no study has evaluated the effect of this activity in patients with fibromyalgia. randomized controlled trial with blinded evaluator, which will be evaluated patients with fibromyalgia were divided into two groups. the intervention group will hold an exercise program of swimming (freestyle) and the other considered the control group held a walking program.

fibromyalgia (fm) is a syndrome characterized by diffuse musculoskeletal pain and chronic, with points called "hot spots", specific, sensitive and painful on palpation. objective: to evaluate the efficacy of swimming in reducing the generally pain and improve the quality of function, of life and exercise capacity in patients with fibromyalgia. material and methods: 82 patients will be screened, diagnosed with fibromyalgia, who can swim the front crawl. will be selected at unifesp outpatient clinics and also through advertisement in a newspaper. one group held the swimming training and the other group (control) will walk training. the participants perform exercises (swimming or running) three times a week for 50 minutes, for 12 weeks. the exercises will be held at the anaerobic threshold determined by cardiopulmonary exercise testing. measuring instrument: questionnaires vas (visual analogue scale) for pain, fiq (fibromyalgia impact questionnaire) to assess the quality of life related to disease, and also the sf-36 (short form health survey), which assesses quality of life in general. cardiopulmonary stress test to assess cardiorespiratory fitness to sit and stand up and test to assess functional capacity. all participants will conduct an initial evaluation, after 6 and 13 weeks of training.

Eligibility criteria:
inclusion criteria: * female patients with fibromyalgia according to the classification criteria of the american college of rheumatology; * patients with degree of pain between 4 and 8 cm by vas-visual analog scale; * patients who can swim the freestyle "(crawl)"; patients with stable-medication for at least three months; * all patients will have signing the consent form. exclusion criteria: * patients with uncontrolled cardiac disease and / or unable to perform aerobic exercises; * patients with severe psychiatric disorders; * patients with uncontrolled diabetes mellitus; * patients who practice regular physical exercise for at least 3 months; * patients with skin diseases that contraindicate the use of swimming pool; * patients with inflammatory rheumatic diseases.

Keywords: fibromyalgia swimming
effects of orally administered beta-glucan on leukocyte function in humans

Conditions: Immunologic Deficiency Syndromes

Summary: the purpose of this study is to test wether orally administered beta-glucan has systemic effects in humans.

the immunostimulatory properties of mushrooms have been recognized for centuries, and "medicinal" mushrooms are still widely used in alternative medicine all over the world. although a number of fungal components have been implicated in these properties, beta-glucans have attracted the most attention. however, although beta-glucans are widely used as a health food supplement, their immunomodulatory effects after administration in humans have not yet been determined.

Eligibility criteria:
inclusion criteria: * written informed consent * age ≥18 * healthy males exclusion criteria: * subjects with a history of allergy or intolerance to beta-glucan * use of any medication * participation in a drug trial or donation of blood 3 months prior to beta-glucan administration * use of antibiotics, norit, laxatives (up till 6 months prior to inclusion), cholestyramine, acid burn inhibitors or immune suppressive agents (up till 3 months prior to inclusion), and pre- and probiotics (up till 1 month prior to inclusion).

Keywords: betaglucan, immune modulation, immunoparalysis, immune suppression
multicenter randomised prospective study for external support mesh vest of venous coronary grafts on the right territory

Conditions: Ischemic Cardiovascular Disease

Summary: multicentre randomised prospective study aimed at verifying medium-term patency of venous grafts on the right coronary artery territory, by clinical and/or instrumental follow-up with particular attention to clinically driven re-revascularisation events regarding the site of new lesions (granularly comparing sites already treated with vest, sites treated with bare vein, sites treated with other conduits, de novo lesions on the native).


Eligibility criteria:
inclusion criteria: * combined or isolated interventions * adequate vein calibre * adequate graft flowmetry exclusion criteria: * inability to implant due to calibre disparity or inadequate flowmetry

Keywords: coronary artery bypass graft
surgical or medical treatment

Conditions: Diabetes Mellitus, Type 2; Pediatric Obesity; Bariatric Surgery Candidate

Summary: this study will test the hypothesis that metabolic bariatric surgery will be more effective at providing durable glycemic control and reduce co-morbidities than intensive medical therapy in youth with type 2 diabetes.

youth-onset type 2 diabetes (t2d) leads to early dependence on exogenous insulin and progression of t2d co-morbidities, including dyslipidemia, hypertension, non-alcoholic fatty liver disease and diabetic kidney disease. the pathophysiology of t2d in youth differs considerably from adults and current treatment approaches are in-adequate for youth. thus, exploration of innovative approaches to reduce co-morbidities is critical. metabolic bariatric surgery (mbs) significantly improves multiple outcomes in adults with t2d. initial small, uncontrolled studies of roux-en-y gastric bypass also suggest beneficial effects in youth with t2d, but definitive studies and understanding of mechanisms in youth-onset t2d are lacking, especially with the now more common form of mbs, vertical sleeve gastrectomy (vsg). we will test the hypothesis that vsg will be more effective in reducing glycemia and comorbidities than the best currently available medical treatment: advanced medical therapy (amt), via pancreatic, enterohepatic and/or metabolic changes. to test this hypothesis, 90 adolescents with t2d will be studied to compare the effects of vsg vs. amt on glycemic control and t2d-associated comorbidities, as well as underlying mechanisms.

Eligibility criteria:
inclusion criteria for the medical or surgical type 2 diabetes groups * age 13-19.9 years of age at time of signing the consent * type 2 diabetes by the american diabetes association criteria * negative diabetes-associated antibodies exclusion criteria for the medical or surgical type 2 diabetes groups known type 1 diabetes, maturity onset diabetes of the young (mody), or secondary diabetes * any chronic oral steroids use within 60 days of enrollment * current pancreatotoxic drugs * chronic kidney or liver disease (except nafld or dkd) * pregnancy, breast-feeding or intension of becoming pregnant * prior bariatric surgery * history of malignancy * current participation in another clinical trial that may affect study outcomes * other conditions, that in the determination of the study investigator, may interfere with study participation * inclusion criteria for the obese control group * age 13-19.9 years of age at time of signing the consent * clinical indication to receive bariatric surgery exclusion criteria for the obese control group * known diabetes * any chronic oral steroids use within 60 days of enrollment * current pancreatotoxic drugs * chronic kidney or liver disease (except nafld or dkd) * pregnancy, breast-feeding or intension of becoming pregnant * prior bariatric surgery * history of malignancy * current participation in another clinical trial that may affect study outcomes * other conditions, that in the determination of the study investigator, may interfere with study participation
the effect of functional exercises on balance with postural thoracic kyphosis

Conditions: Postural Kyphosis; Balance

Summary: in a normal spine, the sagittal plane has four curvatures that balance each other. the cervical and lumbar spine is lordotic, the thoracic spine and sacral region are kyphotic. in the sagittal plane, there is an average of 40 kyphosis angles between the t1 vertebrae upper end plate and the t12 vertebra lower end plate. thoracic kyphosis is defined as an increase in the normal thoracic curvature (above 40) of the spine. postural kyphosis usually occurs when individuals with weak muscle strength exert excessive external loads on their vertebrae. in rapidly growing young people, the abnormal flexion of the spine prevents the development of internal organs and excess thoracic kyphosis causes changes in respiratory functions, as well as postural disorders negatively affect the standing balance. in addition, the posture and appearance of young people with postural kyphosis are affected, which can affect their physical and psychological health.the incidence of hyper-kyphosis abnormality was reported to be 15.3% in 11 year-old children, 38% in 20 to 50 years old adults and 35% in 20 to 64 years old adults. this abnormality is managed by various methods including manual therapy, postural retraining, taping, orthoses and corrective exercises. when a literature review was conducted, it was observed that no balance evaluation was performed in individuals between 18 and 25 years of age who had postural kyphosis. therefore, the aim of this study was to investigate the effect of schroth-based functional exercise and postural exercise on balance, respiratory functions and thoracic angle, who has with postural kyphosis and 18-25 years of age.

participants will be randomly allocate 40 participants with kyphosis to two groups; group i (n=20), group ii (n=20). the group i, will receive postural exercise for 60 min/day 2 times/week for 8 weeks, while the group ii receive schroth three-dimensional exercise therapy program for 60 min/day 2 times/week for 8 weeks. assessment procedure will be held at the beginning and 9th week of study. all subjects will be assessed by each angle of thoracic kyphosis, forward head and forward shoulder angles were measured by using the lateral photographic method, trunk flexibility (lateral and hyperextension), balance (bi̇odex balance system) , respiratory function test (measurement of pulmonary function and respiratory muscle strength) , quality of life srs-22 and numeric rating scale for pain.

Eligibility criteria:
inclusion criteria: * aged between 18 and 25 years, * thoracic kyphosis angle ≥ 40, * not being treated for kyphosis within the last six months. exclusion criteria: * who has mental problem, * spinal fractures and / or operative stories, * shoulder joint injury, * participants who can not come to the exercise program.

Keywords: postural kyphosis exercises balance respiratory functions
efficacy of cardioviva™ probiotic yogurt formulation

Conditions: Hypercholesterolemia

Summary: background: several studies have reported limited or no reduction in serum lipid concentrations in response to probiotic formulations. more recently, probiotics have shown promise in treating metabolic disease, due to improved strain selection and delivery technologies. objective: to evaluate the lipid lowering efficacy of a yogurt formulation containing microencapsulated bile salt hydrolase (bsh)-active lactobacillus reuteri cardioviva, taken twice per day over 6 weeks, in subjects with hypercholesterolemia. design: this is a double-blinded, multi-centric, placebo-controlled, randomized, parallel-arm study. the study will last a total of 10 weeks including 2-week wash-out, 2-week run-in, and 6- week treatment period.


Eligibility criteria:
inclusion criteria: * healthy males and females. * aged 18-74 years old. * low density lipoprotein (ldl-c) above 3.4 mmol/l (\<15% variation between visits v1 and v2-1). * triglyceride (tg) levels below 4.0 mmol/l (check at v0 and v2-1). * body mass index (bmi) range was 22 to 32 kg/m2. * ability to understand dietary procedures. * judged by the investigators as compliant (\>80%) with product consumption (check at v2-1), and motivated. * signed informed consent form prior to inclusion in the study * note: subjects were permitted to take stable doses of thyroid hormone, anti-hypertensive agents, and contraceptive hormones (e.g. contraceptive pills or patches), as long as these were continued equivalently throughout the duration of study. exclusion criteria: * use of statin or other cholesterol lowering prescription drugs within the last 6 months. * use of plant sterols, omega-3, fish oil, soy protein, soluble oat fiber, psyllium seed husk, or other cholesterol lowering non-prescription supplements within last 3 months. * history of chronic use of alcohol (\>2 drinks/day). * use of systemic antibodies, corticosteroids, androgens, or phenytoin. * myocardial infarction, coronary artery bypass, or other major surgical procedures within the last six months. * lactose intolerance or allergies to dairy products. * history of angina, congestive heart failure, inflammatory bowel disease, pancreatitis, diabetes, gastrointestinal, renal, pulmonary, hepatic or biliary disease, or cancer (evidence of active lesions, chemotherapy or surgery in the past year). * chronic user of probiotics or fiber laxative (greater than 2 doses/week), or stimulant laxatives. * history of eating disorders. * exercise greater than 15 miles/week or 4,000 kcal/week. * pregnancy, breast feeding, or intent to get pregnant.

Keywords: yogurt probiotic cholesterol
study of sy-201 ophthalmic solution in subjects with dry eye disease

Conditions: Dry Eye Disease

Summary: this is a phase 2, multi-center, double-masked, randomized, vehicle-controlled, dose-response, parallel-group study designed to evaluate the safety and tolerability and ocular efficacy of sy-201 ophthalmic solution versus vehicle over a 60-day treatment period in subjects with dry eye disease (ded).


Eligibility criteria:
* inclusion criteria 1. provide written informed consent prior to any study-related procedures. 2. are 18 years of age or older. 3. are willing and able to follow instructions and can be present for the required study visits for the duration of the study. 4. have a best corrected visual acuity (bcva) in each eye, using corrective lenses if necessary, of +0.7 logarithm of the minimum angle of resolution (logmar) or better as assessed by the early treatment of diabetic retinopathy study (etdrs) at visit 1. exclusion criteria: 1. unanesthetized schirmer test score in either eye \<2 mm/5 minutes at visit 1. 2. any concomitant treatment or prior ocular procedure or surgery in either eye or alteration of the dose of systemic medications at the time of entry into the study that could interfere in the assessment of the trial 3. have corneal erosive disease (e.g., confluent staining \[national eye institute (nei) grade 4\], confluent filaments) or other conditions suggestive of extensive damage of the cornea in either eye. 4. have a history of glaucoma or intraocular pressure (iop) \>25 mmhg at visit 1 or a history of elevated iop (\>25 mmhg) in either eye. 5. wear contact lenses for 14 days prior to visit 1 or throughout the study.
walking on cognitive function in individuals with mild cognitive impairment: a pilot project

Conditions: Cognitive Impairment, Mild

Summary: background: many studies suggest physical activity reduces risk of dementia and improves global cognitive function in individuals with mild cognitive impairment (mci). using commercial wearable technology to measure daily steps is feasible in this population. objectives: the purpose of this pilot study was to explore whether 12 weeks of increased physical activity improved cognitive function in individuals with mci. a wearable activity tracker was used to measure participants' daily steps as a quantifiable measure of daily activity level. design: this was a one-group pretest-posttest study. setting: established memory clinic patients within a neurology department in northern california during 2019. participants: 17 enrolled and 14 included for data analysis. there were 7 females and 7 males whose mean age was 76.21 (sd 2.69). 12 participants were white, which reflected the clinic population. intervention: participants were asked to wear an activity tracker for approximately 12 hours a day for 12 weeks and to increase their physical activity as much as possible. they were provided twice a month telephone support. measurements: the montreal cognitive assessment (moca) was used to measure pretest-posttest cognitive function. timed up and go (tug) was used to assess fall risk at enrollment. cumulative step count for the study period was measured with an activity tracker.


Eligibility criteria:
inclusion criteria: * participants had a score of 0.5 on the clinical dementia rating and are on a stable medication regimen for 3 months prior to enrollment. exclusion criteria: * a diagnosis of dementia; receiving chemotherapy; unstable chronic diseases; surgery with general anesthesia in the prior 3 months; mri-confirmed brain damage from trauma, stroke, or other neurological disorder; a myocardial infarction \ 26 or \<16; already using a wearable activity tracker; lacked access to the internet; or non-english speaking.
comparison of the effectiveness of treatments in carbon monoxide intoxications

Conditions: Carbon Monoxide Poisoning

Summary: carbon monoxide (co) poisoning is a condition that occurs as a result of inhaling carbon monoxide gas and can potentially lead to serious health issues. the treatment of co poisoning requires urgent medical intervention. methods used in the treatment of co poisoning include normobaric oxygen (oxygen at normal pressure), high-flow oxygen, non-invasive continuous positive airway pressure (cpap), and hyperbaric oxygen therapy. studies on these methods are available in the literature.

when examining the mechanisms of application for these methods: normobaric oxygen therapy: in normobaric oxygen therapy, researchers treat participants with normobaric (sea level) oxygen. this method provides high concentrations of oxygen, allowing better oxygen saturation of the blood and faster removal of carbon monoxide from the body. participants inhale normobaric oxygen through devices such as masks or nasal cannulas. high-flow oxygen therapy: in high-flow oxygen therapy, researchers treat participants with high-flow oxygen. typically, a nasal cannula or oxygen mask is used. the high flow rate allows more oxygen to reach the alveoli and bind to hemoglobin. this method can be effective, especially in more severe cases of carbon monoxide poisoning. non-invasive cpap therapy: non-invasive cpap therapy is typically used to treat respiratory problems such as sleep apnea but can also be used in the treatment of co poisoning. participants receive oxygen under continuous positive airway pressure with the help of a mask. comparison of these methods: normobaric oxygen is considered the standard treatment for co poisoning and generally effectively eliminates carbon monoxide from the body. high-flow oxygen may be more effective in providing additional oxygen in more severe cases, but it works similarly to normobaric oxygen. the choice of which treatment method to use can vary depending on the participant's clinical condition, the severity of poisoning, and other factors. the researchers main goal in designing this study is to determine which treatment, depending on the researcher's decision, most rapidly shortens the half-life of carbon monoxide in participants experiencing severe carbon monoxide poisoning.the researchers aim to identify which treatment participants tolerate better and which method minimizes complications related to co intoxication.

Eligibility criteria:
inclusion criteria: * between the ages of 18 and 65, * without any underlying health conditions, * diagnosed with carbon monoxide poisoning, * capable of providing consent either personally or through a legal representative. exclusion criteria: * under the age of 18, * over the age of 65, * with underlying health conditions, * without a diagnosis of carbon monoxide poisoning, * patients who do not wish to share their data.
effectiveness of an intervention plan aimed at the diaphragm in chronic non-specific neck pain

Conditions: Chronic Neck Pain

Summary: the aim of this study is to analyse the effectiveness of an intervention plan targeting the diaphragm, namely stretching technique, neuromuscular diaphragm and phrenic centre inhibition, in the treatment of chronic non-specific neck pain.

chronic neck pain is defined as pain and discomfort between the superior nuchal line and the spinous process of the first thoracic vertebra, which may radiate to the scapula, anterior chest wall, skull or upper limbs. it is classified as chronic if the pain persists for more than 12 weeks. associated symptoms include headache, dizziness and pain or paresthesia in the upper limbs. these symptoms interfere with daily life and have a negative impact on physical and mental health. the aetiology of this pathology is multifactorial and the triggering factors may vary due to the close relationship that the cervical spine has with other structures, namely the diaphragm muscle. our aim is to verify the effectiveness of an osteopathic treatment protocol targeting the diaphragm in chronic non-specific neck pain in young adults. specifically, to analyse whether the mechanical, fascial and neural pathways established by the defined manual techniques, namely stretching techniques, neuromuscular inhibition of the diaphragm and the phrenic centre, have any effect on active movements (rotations and inclinations) and chronic neck pain. this study will analyse the effects of diaphragmatic techniques on the following variables: numerical pain scale and goniometer pro© (g-pro©).

Eligibility criteria:
inclusion criteria: * present a negative jackson test; * have a body mass index (bmi) of 20-29.9 kg/m2; * suffer from chronic non-specific neck pain for 3 months or more. exclusion criteria: * have a history of cervical spine surgery, as well as any trauma or fracture of the cervical spine, clavicle, scapula and ribs; * have specific neck pain due to degenerative diseases (disc prolapse, scoliosis); * having a congenital cervical deformity, such as torticollis; * being pregnant; * having rheumatic, oncological or respiratory pathologies; * have liver or gallbladder pathologies; * receiving physiotherapy, osteopathy, acupuncture or massage treatment for neck pain 3 months before and during participation in the study; * taking analgesics, anti-inflammatories or muscle relaxants 5 days prior to the intervention.

Keywords: neck pain diaphragm cervical spine young adult osteopathy
single patient protocol for an nrg1 fusion positive metastatic pancreatic cancer patient using seribantumab

Conditions: Metastatic Pancreatic Cancer

Summary: nrg1 gene fusions are extremely rare across solid tumours (estimate 0.3-0.5%). however, it is felt to be an actionable and potentially major growth pathway for those tumours that harbour this gene rearrangement. tumours that harbour nrg1 fusions are driven by her3 overactivation. seribantumab is a mono-clonal antibody against her3, it binds her3 and inhibits nrg1-dependent activation and her2 dimerization.


Eligibility criteria:
inclusion criteria: * serious, life-threatening condition * not eligible for, or exhausted all other treatment options or causing significant toxicity * no other way to access treatment exclusion criteria: -