Kornimate/medical-research-clean huggingface dataset:
the impact of parent training on the child's health services

Conditions: Parenting; Child Rearing; Child Behavior Problem

Summary: the purpose of the study is to determine whether parent training with the incredible years parent program delivered in pediatric primary care decreases usage of healthcare services for the next year when compared to annual healthcare service use during the two years prior to the parents participating in program.

pediatric health services utilization (phsu) by children with mental health conditions demonstrated dramatic increases between 2006 and 2011. these national trends reflecting large increases in phsu for mental health conditions were seen across multiple developmental levels. health services costs for children with mental health conditions are estimated to be twice those for the average child. the incredible years® parent program (iy) has a strong evidence-base supporting its effectiveness in reducing early onset conduct problems. the overall objective of this stage 3 (t3) translational research proposal is to conduct a pilot study of 45 pediatrician-referred parents who participate in iy and examine the impact of iy on phsu of their children. pediatric hsu outcome measures include: all-cause ed visits; in-patient hospitalizations and length of stay; authorizations for specialist referrals; primary and acute care visits; and ed visits for mental health conditions. the investigator's central hypothesis is that children ages 3 to 6 years with behavior concerns whose parents are referred by their pediatricians for participation in iy will have decreased mean annual all-cause phsu and decreased ed visits for mental health conditions in the 12 months following iy, compared to the 24 months prior to iy participation. this is important to demonstrate because significant financial barriers exist to integrating effective family focused prevention services like iy into pediatric primary care settings. demonstration of reduced phsu is one way to address these translational barriers. results of this pilot study are expected to provide preliminary data on pre- and post-intervention effect sizes; these data will be used to demonstrate the feasibility of collecting data using existing sources of phsu to design a more fully powered multi-site trial with a robust comparator group.

Eligibility criteria:
inclusion criteria: * children receiving primary care at chla altamed with parent-reported behavioral concerns whose parents are referred by their pediatricians for participation in the incredible years parenting program. * continuous enrollment in altamed medicaid funded health services during the 24 months prior to participation in iy and 12 months following participation in iy with lapses in coverage of no more than 90 days in length. * parents are english or spanish-speaking or willing to use interpretation if they speak another language. exclusion criteria: * private (commercial non-medicaid) insurance coverage for greater than 90 days during the 24 months prior to participation in iy and 12 months following participation in iy.

Keywords: child health services pediatric health service utilization incredible years
hemorrhoids and metalloproteinases, observational study

Conditions: HEMORRHOIDS; Extracellular Matrix Alteration

Summary: an association between hemorrhoidal disease and matrix metalloproteinases (mmps) has been described previously. mmps regulate extracellular structural proteins and tissue remodeling. neutrophil gelatinase-associated lipocalin (ngal) is involved in the regulation of mmp activity. the aim of this work was to study the relationship between the levels of mmps and ngal and different stages hemorrhoids. the study provides potentially important insights to the understanding of the natural history of hemorrhoids and mmps and ngal regulation.

introduction. an association between hemorrhoidal disease and matrix metalloproteinases (mmps) has been described previously. mmps regulate extracellular structural proteins and tissue remodeling. neutrophil gelatinase-associated lipocalin (ngal) is involved in the regulation of mmp activity. the aim of this work was to study the relationship between the levels of mmps and ngal and different stages hemorrhoids. methods. in a multicenter, open-label, prospective study, patients with hemorrhoids were recruited and represented the group i (patients with symptomatic hemorrhoids - grade i to iv sec. goligher), a further group of healthy volunteer subjects were also recruited as the control group (group ii). enzyme-linked immunosorbent assay and western blot analysis will evaluate the levels of immunoreactive mmps and ngal in all patients with hemorrhoids.

Eligibility criteria:
inclusion criteria: * patients with hemorrhoids of both sex exclusion criteria: * patients with cancer * hepatic failure * infectious or autoimmune diseases * arthritis * arterial aneurysms * hernias * chronic venous disease * nephritis, vascular ulcers, fibrosis, and other diseases associated with increased levels of mmps were excluded from the study. * patients treated with corticosteroids or cytostatic drugs were also excluded.

Keywords: hemorrhoids mmp ngal matrix metalloproteinases
lipid-lowering therapies in vietnamese chronic kidney disease population

Conditions: Hypercholesterolemia; Chronic Kidney Diseases

Summary: this study aims to determine the mechanisms underlying dyslipidemia in chronic kidney disease (ckd) and effect of lipid-lowering therapies in patients with ckd via parameters of lipid, oxidative stress, tryptophan delegation as well as renal function and side effects. thirty 3,4 ckd patients with low-density lipoprotein (ldl) \> 100 mg/ml (2,59mmol/l), randomly receive three different ldl lipid-lowering therapies: simvastatin (40 mg/day) or ezetimibe/simvastatin combination (10/20 mg/day or 10/40 mg/day).

the prevalence of chronic kidney disease (ckd) in vietnamese population is increasing along with hypertension and diabetes. in ckd patient, cardiovascular disease (cvd) is the leading cause of mortality. the lipidemic disorder is one of the cv risk factors in ckd but it was not fully concerned in viet nam. hypocholesterolemia therapy has shown many benefits; however, its effects on os and endothelial function are still not fully evidenced. in clinical practice, physicians always concern the effects and safety before giving the prescription. however, despite the high frequency of statin treatment, only 1/3 of ckd patients achieved the ldl-c goal. whether high-dose of statins mono-therapy is more effective in ldl-c lowering is still unclear, but are associated with a high rate of hepatotoxicity, myopathy. lowering ldl-c with statin mono-therapy and statin/ezetimibe combination reduces the risk of cvd in population without kidney disease. which cholesterol-lowering therapies are suitable for stage 3,4 ckd patients in term of e-gfr reduction and side effects? there is no data related to this field in the vietnamese ckd population. thus, more advanced lipid-lowering therapies and a better understanding of the mechanism is needed for treatment strategy of hyperlipidemia in vietnamese patients with ckd.

Eligibility criteria:
inclusion criteria: * ages eligible for study: * ≥ 50 years old but not treated with chronic dialysis or kidney transplantation * in adults aged 18-49 years with ckd but not treated with chronic dialysis or kidney transplantation, statin treatment in people with one or more of the following: known coronary disease (myocardial infarction or coronary revascularization); diabetes mellitus; prior ischemic stroke; estimated 10-year incidence of coronary death or non-fatal myocardial infarction \> 10%. * ckd in the 3,4 stage: (e-gfr: 15-60 ml/min/1.73 m2) * ckd proteinuria (defined as creatinine clearance \>20 ml/min/1.73 m2 combines with urinary protein excretion rate \>300mg/24 h) * ldl cholesterol concentration \> 100 mg/dl (2,59 mmol/l) exclusion criteria: in adults with dialysis-dependent ckd * heart failure (new york heart association class iii or more) * previous or concomitant treatment with corticoids, statin, immunosuppressive agents, vitamin b6, b12, folate. * pregnancy * patients who do not agree to participate the research * patients are unable to understand the purposes and the risks of the study

Keywords: chronic kidney disease lipid lowering therapy hypercholesterolemia
effectiveness of a self-rehabilitation program

Conditions: Cervicalgia

Summary: the prevalence of non-specific neck pain is 12.1 / 1000 patients / year. their support is most often based on analgesics combined with physical therapy. more recently authors have advocated the use of self-rehabilitation, that is to say, the use by the patient himself of physiotherapy exercises to perform at home regularly. however, if there are currently many studies on the effectiveness of self-rehabilitation for low back pain, there are few data on neck pain. in this context we have chosen to implement a prospective, randomized study, on the effectiveness of self-rehabilitation in patients with chronic neck pain.

patients included in the "self-rehabilitation" group will, in addition to conventional physiotherapy, to visit two training sessions in self-rehabilitation at the hospital. each patient received a booklet including advices to perform different kinds of exercises at home. the patients learn the exercises with the help of the physiotherapist and have to traine daily at home. patients will have to answer questionnaires about their pain at follow-usual consultations of their disease at 2 months and 4 months after the start physical therapy and during a phone call after 1 year.

Eligibility criteria:
inclusion criteria: * non-specific neck pain \* ≥ 15 days / month for more than 3 months * consultation first line in the pain center * subject able to complete questionnaires * subject able to understand and perform exercises exclusion criteria: * history of stroke * history of carotid or vertebral arterial dissection * "whiplash" for less than six months * cervicobrachial neuralgia for less than 3 months * syndrome of thoracic outlet diagnosed * tumor and infectious syndromes * polyarthritis or major cervical spondylosis against known-indicating active mobilization of the cervical spine * unbound bone trauma * patients with cognitive impairment prevents proper application instructions

Keywords: cervicalgia self-rehabilitation physiotherapy
expression of trefoil factors and adrenomedullin in subjects with chronic periodontitis and coronary heart disease

Conditions: Coronary Heart Disease; Periodontal Diseases

Summary: to assess the demographic variables, periodontal parameters and to determine the expression of trefoil factors 2 and 3 and adrenomedullin in unstimulated saliva samples of periodontally healthy subjects with coronary heart disease and generalised chronic periodontitis subjects with and without coronary heart disease.

a total of 75 subjects will be recruited for the study based on the power of the study. the selected subjects will be divided into 3 groups based on inclusion and exclusion criteria. group i:25generalized chronic periodontitis subjects without coronary heart disease. group ii: 25generalized chronic periodontitis subjects diagnosed with coronary heart disease. group iii: 25periodontally healthy subjects diagnosed with coronary heart disease. demographic variables, periodontal parameters and biochemical parameters will be measured in all three groups

Eligibility criteria:
inclusion criteria: 1. patients willing to participate in the study. 2. patients within the age group of 30-65 years. 3. patients should have ≥ 20 remaining natural teeth. 4. for group i • systemically healthy, generalized chronic periodontitis subjects with 30% or more sites with clinical attachment loss (cal) ≥ 2mm, radiographic evidence of alveolar crestal bone loss ≥ 2mm from the cemento-enamel junction. 5. for group ii • generalized chronic periodontitis subjects with 30% or more sites with clinical attachment loss (cal) ≥ 2mm, radiographic evidence of alveolar crestal bone loss ≥ 2mm from the cemento-enamel junction along with coronary heart disease. 6. for group iii • periodontally healthy subjects with probing pocket depth (pd) less than 4mm, bleeding on probing (bop) at ≤15% of tooth sites, no periodontal treatment (scaling and root planing or periodontal surgery) within the previous 6 months and without evident clinical signs of gingival inflammation along with the presence of coronary heart disease. exclusion criteria: 1. subjects with systemic conditions such as type i and type ii diabetes mellitus, respiratory diseases, renal disease, liver disease, rheumatoid arthritis, allergy, advanced malignancies and hiv infection will be excluded from the present investigation. 2. for group i, subjects on drugs such as corticosteroids, antibiotics, within 6 months of investigation will be excluded. 3. current smokers and individuals who quit smoking less than 6 months. 4. patients who have undergone periodontal therapy within the previous 6 months. 5. pregnant women (pregnancy may alter the oral flora)

Keywords: periodontitis saliva trefoil factor adrenomedullin coronary heart disease
intellectual enrichment to build cognitive reserve in ms

Conditions: Cognitive Impairment in Multiple Sclerosis

Summary: cognitive problems are a primary concern for people with multiple sclerosis. in many cases, people with ms report these issues to be more debilitating than the motor symptoms that are targeted by most treatment strategies. for people with ms, impaired memory and thinking skills can interfere with the ability to function efficiently in multiple professional and personal roles. finding ways to decrease, slow, or reverse declines in memory and thinking skills is a vitally important research priority. we now know that engaging in intellectually enriching activities helps protect against the negative impact of ms disease-related declines in memory and thinking. such activities contribute to something called 'cognitive reserve,' which serves as a protection against disease-related declines in memory and thinking. thus far, no one has created a treatment that aims to provide a concentrated 'dose' of intellectual enrichment to build cognitive reserve. the present intervention aims to do precisely this. here, we have developed a program of enriching activities that are delivered via a personal ipad. this allows for a 12-week 'treatment' that is entirely home-based, while also providing close personal contact between participants and our study personnel, who will communicate daily via emails. week by week, participants choose from a menu of intellectually enriching activities such that their treatment is dynamic and customizable to fit their interests. the intervention is designed to be fun, as we hope the activities will be incorporated into people's lives beyond the period of the study itself. given what we already know about the striking benefits of cognitive reserve to protect against disease-related declines in cognitive functioning, we expect to show that treatment with a daily, intense, intellectually enriching schedule of activities results in improved thinking and memory for people with ms. we will also investigate the positive impact of our treatment on the brains of people with ms through brain scans. we expect to see evidence for a shift toward more efficient processing in the brain, changes that translate to improved memory and thinking skills.


Eligibility criteria:
inclusion criteria: * age 25-65 * ms duration \>5 years * read and speak english fluently exclusion criteria: * currently experiencing an ms exacerbation * ms exacerbation within 6 weeks of study start * left handed * non-mri compatible: metal in body, claustrophobic * history of neurological disorder other than ms * history of head injury * history of schizophrenia or bipolar disorder * pregnant * currently taking steroids, benzodiazepines, and/or neuroleptics * do not speak english as primary language

Keywords: cognitive reserve intellectual enrichment
two cancers, one gene. why some people in families develop melanoma or pancreas cancer, while still others never develop cancer.

Conditions: Pancreas Cancer; Melanoma

Summary: individuals who are affected with pancreas cancer and melanoma as well as those without either cancer who have been identified as 1st or 2nd degree relatives of family members with pancreas cancer and melanoma will be asked to participate. the participant will be asked to complete a survey about their health and family history of cancer and to give a blood sample for specific gene testing and storage for future research studies.the overall goal of this study is to understand the factors that increase susceptibility and expression of pancreatic cancer and melanoma in high risk families.


Eligibility criteria:
inclusion criteria: * individuals who are affected with pancreas cancer and melanoma as well as those without either cancer who have been identified as 1st or 2nd degree relatives of family members with pancreas cancer and melanoma. exclusion criteria: * under the age of 18, non-english speaking or unable to provide informed consent, inmates.
bio|stream.icm france

Conditions: Syncope; Cryptogenic Stroke

Summary: the main objective of the bio│stream.icm france submodule is to provide clinical evidence from patients in france on safety and efficacy of the biomonitor system

the bio\|stream.icm submodule will recruit a subset of patients with syncope with uncertain origin and cryptogenic stroke without history of atrial arrhythmia from the existing population enrolled in the bio\|stream.icm registry. the submodule study is designed to provide clinical evidence from patients in france on safety and efficacy of the biomonitor system.

Eligibility criteria:
inclusion criteria: * indication for icm device in accordance with the european guidelines: syncope with uncertain origin or cryptogenic stroke without history of atrial arrhythmia * enrolled in the bio\|stream.icm registry exclusion criteria: * life-expectancy is less than 3 months * already implanted with biomonitor
competency-based assessment of ultrasound-guided joint injection skills

Conditions: Musculoskeletal Diseases

Summary: ultrasound-guided joint injections and aspirations are frequently used in the treatment of rheumatological diseases. studies have shown that intra-articular glucocorticoid injections (iagcs) in the early treatment of rheumatoid arthritis is essential and leads to improved disease control and earlier achievement of remission. unfortunately, many rheumatologists feel insecure performing iagc due to poor and unstructured training opportunities, which can result in suboptimal treatment and potentially poorer patient outcome. nowadays, the gold standard training method has shifted towards competency-based education were objective assessment tools are necessary. a previous study has developed a scale for assessment of invasive ultrasound procedures, the interventional ultrasound skills evaluation (iuse) tool. although expert consensus supports evidence of content validity of the assessment tool, it is not known if the tool can discriminate differences in performance scores between the different levels of experience.


Eligibility criteria:
inclusion criteria: * physicians attending the yearly international conference eular (denmark 2022) 1. novices: no or little experience with ultrasound guided joint injections. 2. intermediates: participated and completed at least one formal musculoskeletal ultrasound course and performed more than 100 ultrasound guided joint injections. 3. experts: physicians with a long experience with musculoskeletal ultrasound and ultrasound guided joint injections doing the procedure almost daily and providing teaching and/or research within this field. exclusion criteria: * no informed consent * novices/intermediates: extensive experience with musculoskeletal ultrasound and/or ultrasound guided joint injections.

Keywords: training ultrasound medical education
exercise and nutrition interventions during chemotherapy

Conditions: Neuropathy;Peripheral

Summary: this is a feasibility pilot study to initiate a research program to assess the effects of exercise on chemotherapy-induced peripheral neuropathy (numbness, tingling, and pain in the hands and feet).

this is a feasibility pilot study to help obtain external funding for a larger study to assess the effects of exercise on chemotherapy-induced peripheral neuropathy (cipn), which is a dose-limiting and painful side effect of chemotherapy for which there are no established treatments. the investigators will conduct a two-arm randomized clinical trial in 40 cancer patients receiving chemotherapy where arm 1 is 12 weeks of exercise during chemotherapy and arm 2 is 12 weeks of nutrition education (control condition) during chemotherapy. the investigators will acquire data on cipn via patient reports and clinical assessments as well as general pain and hypothetical mechanistic factors that may help explain how exercise may treat cipn; these factors include measures of musculoskeletal, cardiovascular, neuropsychological, and immunological function. the primary outcomes are related to the feasibility of identifying, recruiting, and obtaining complete data from research participants.

Eligibility criteria:
inclusion criteria: * have non-metastatic cancer * be chemotherapy naïve * be scheduled to receive cipn-inducing chemotherapy during the study (platinums, vinca alkaloids, taxanes, thalidomide, or bortezomib) for the duration of the intervention (12 weeks) * report symptoms of peripheral neuropathy at baseline (subject-reported severity of numbness and tingling in hands/feet of at least 1 on a 0-10 scale) * be able to perform the exercise intervention * be able to read english * be at least 18 years old (no upper limit on age) * be consistently right-handed in daily activities for consistency in reporting any lateralized effects from brain imaging * provide written informed consent exclusion criteria: * receive surgery, radiation, or hormone therapy for their cancer during the study * be in the active or maintenance stage of exercise behavior (i.e., subjects must be sedentary) * have contraindications for mri scanning (pacemaker, metal implants, pregnancy, etc. - note that most port-a-caths are safe for mri scanning) * have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in maximal physiological fitness testing and a low/moderate intensity home-based walking and progressive resistance exercise program.

Keywords: cipn chemotherapy-induced peripheral neuropathy
a study of krn23 in x-linked hypophosphatemia

Conditions: X-linked Hypophosphatemia

Summary: the primary objective of this study is to assess the safety and tolerability of krn23 after a single intravenous (iv) and subcutaneous (sc) administration in xlh patients.


Eligibility criteria:
inclusion criteria: 1. 18 years or older 2. clinical diagnosis of xlh 3. tmp/gfr is less than 2.0 mg/dl 4. gfr is 60 ml/min or above exclusion criteria: 1. have any sign of active infectious disease or have had an infection requiring treatment with antibiotics within three weeks prior to screening 2. history of known immunodeficiency 3. lactating females, female patients who are pregnant or planning to become pregnant during the study 4. use of a pharmacologic vitamin d metabolite or its analog, phosphate, calcimimetics, and ingestion of aluminum hydroxide antacids within 10 days prior to screening and dosing 5. use of any supplement contained phosphate, calcium and/or vitamin d within 10 days prior to screening and dosing 6. receipt of live (attenuated) vaccine within 3-months prior to screening 7. have any condition which, in the opinion of the investigator, could present a concern for either patient safety or difficulty with data interpretation

Keywords: xlh