Kornimate/medical-research-clean huggingface dataset:
cheese intake,cla and hypercholesterolemia

Conditions: Modifications of LDL Cholesterol; Modifications of Enocannabinoid Levels

Summary: in this study the investigators aimed at verifying whether consumption of a sheep cheese, naturally enriched in ala, cla and va, would modify the plasma lipid and endocannabinoid profiles in mild hypercholesterolemic subjects. this study was a 3-week, randomized, double blind, controlled, cross over clinical trial, conducted at the state hospital brotzu in cagliari, italy. the subjects were randomly assigned to eat 90g/d of the control or enriched cheese for 3 weeks, with a cross over after 3 weeks of washout.


Eligibility criteria:
inclusion criteria: * adult volunteers with diagnosed mild hypercholesterolemia (total cholesterol 220-290 mg/dl) exclusion criteria: * pregnant (or those planning to become pregnant during the study period) and lactating women * also individuals with a self-reported history of diabetes, inflammatory bowel disease, pancreatitis, gallbladder or biliary disease in the past 12 months, and lactose intolerance before the screening visit. * those with a history of cancer (except non-melanoma skin cancer) in the 2 years before screening, or of any major trauma or surgical event within 3 months before screening. * volunteers with the following characteristics were also excluded: * total cholesterol ≥300 mg/dl, serum triglycerides ≥250 mg/dl or ≤ 200 mg/dl, \*hdl ≥70mg/dl, bmi ≥ 30 * uncontrolled hypertension (systolic blood pressure ≥160 mm hg or diastolic blood pressure ≥100 mm hg) at screening. * use of lipid-altering medications or supplements, and of anticoagulants, during the 2 weeks before screening and throughout the study was prohibited. * furthermore, we selected subjects with an apo e aplotype 3/3, the most common in sardinia, in order to avoid any variability in cholesterolemia due to a different dietary response.

Keywords: conjugated linoleic acid ldl-cholesterol endocannabinoids
effect of early assessment team for patients referred to outpatient mental health care

Conditions: Mental Disorder

Summary: loss of function and incapacity for work as a result of mental disorders are increasing, especially among young people (under 30 years of age), even though the prevalence of mental illness is fairly stable. many of the patients referred to outpatient mental health care have complex difficulties with both mental and somatic ailments, in addition to difficulties with social conditions related to, for example, education, work, finances and social support. functional difficulties can come as a result of mental illness. however, it can also be the opposite way; not functioning at work, study or daily life in general can cause mental symptoms and ailments. many of these people are referred to mental health care even if the basic problem cannot be solved by psychotherapy or medication. some of the referred patients do not have a psychiatric illness, but a reaction to a stressful and demanding situation and strains over time. compound health challenges require individualized assessments and clarifications in order to offer the right measures. traditionally in mental health care, the patient is placed on a waiting list to receive assessment and therapy for a specific condition. with this background, the investigators believe it is important to early identify the referred patients who will benefit from measures other than traditional assessment and treatment in mental health care. knowledge of other aid agencies is important to find the right measures at the right time. this is important for the individual patients, who are often young people going to "get started in life". it is also important for the health services because the capacity to provide a good health service is a limited resource. from a societal perspective it is important that the health care offered contributes to reducing social security dependence. the purpose of this randomized, controlled trial is to compare the effect of traditional management of newly referred patients in outpatient clinics with assessment through an early assessment team. the investigators believe that early assessment may have a positive effect on mental health, quality of life and function. the outcome goals can be summarized as less use of resources in outpatient clinics and society and better function and life for patients.


Eligibility criteria:
inclusion criteria: * all patients referred to a general psychiatric outpatient clinic * necessary capacity to consent * master norwegian language to such an extent that the patient can understand the written consent exclusion criteria: * patients that an admission team at the outpatient clinic consider obviously must have a tau for some time * patients too healthy to receive specialized mental health care * patients in need of acute psychiatric assessment * relevant participants who do not respond digitally or who do not confirm consent in writing within given deadlines
victim impact modules for jail inmates

Conditions: Substance Abuse; HIV Risk; Shame; Guilt; Empathy; Criminogenic Thinking

Summary: the purpose of this study is to evaluate feasibility of modularized delivery of the impact of crime (ioc) group intervention with jail inmates, and obtain preliminary data on its effectiveness in reducing post-release recidivism, substance abuse, and hiv risk behavior.


Eligibility criteria:
inclusion criteria: * must be 18 years or older * must be male * must be currently incarcerated jail inmate * must be sentenced * sentence must be short enough to serve out sentence at adc * release date must follow projected final session of treatment * must speak, read, and write in english with sufficient proficiency to use workbook and participate in group sessions * must be assigned to the jail's "general population" exclusion criteria: * actively psychotic * assigned "keep separate" from other group members

Keywords: criminal behavior substance abuse hiv risk behavior criminogenic thinking shame guilt empathy jail inmates restorative justice crime
body surface gastric mapping in patients on semaglutide

Conditions: Semaglutide-Induced Gastric Motility; Gastroparesis

Summary: glucagon-like receptor-1 agonists (glp-1 ras), such as semaglutide (ozempic), are a class of drugs used for glycemic control in diabetes, and for weight loss and management in obesity. it has been shown to delay gastric emptying and lead to gastrointestinal symptoms. however, the exact mechanisms are unknown. alterations in gastric function, including myoelectrical activity, may be a likely mechanism of gastrointestinal side effects. body surface gastric mapping (bsgm) using the fda-approved medical device gastric alimetry is a novel non-invasive diagnostic tool to assess gastric myoelectrical activity and patient-reported symptoms to achieve accurate non-invasive biomarkers of gastric dysfunction. a proof-of-principle case study of ozempic using gastric alimetry showed abnormal gastric myoelectrical activity along with the development of severe bloating following the meal after 5 weeks of ozempic use. this study will extend on this initial finding by conducting an exploratory pilot study to investigate the effects on gastric motility in patients with and without diabetes before and after ozempic. it is hypothesized that gastric alimetry will show changes in gastric myoelectrical activity and symptoms in patients after being on the weekly injectable ozempic compared to baseline.


Eligibility criteria:
inclusion criteria: * \>18 years old * no gastrointestinal symptoms based on rome iv criteria * for diabetics: diagnosed t2dm (defined as hba1c levels \> 7%) * for diabetics: fasting blood glucose level \< 15 mmol/l exclusion criteria: * current use of ozempic, similar glp-1 ras or regular insulin in the last 3 months * confirmed gastroparesis on gastric emptying scintigraphy * pregnant or breast-feeding * inability to perform a bsgm test according to indications for use: history of severe skin allergies or sensitivity to cosmetics or lotions; chronically damaged or vulnerable epigastric skin (fragile skin, wounds, inflammation); unable to remain in a relaxed reclined position for the test duration.

Keywords: semaglutide glp-1 receptor agonist gastric motility body surface gastric mapping
lighting intervention for cancer-related fatigue

Conditions: Breast Cancer; Prostate Cancer; Hematologic Malignancy; Survivorship; Fatigue

Summary: fatigue is a major problem for cancer patients, and one that can persist long after treatment ends. recent work has demonstrated that light therapy may mitigate or reduce fatigue levels in both cancer patients and cancer survivors. this protocol seeks to assess how lighting interventions distributed through a mobile app affect fatigue, sleep, and quality of life across three populations of cancer patients: breast cancer and prostate cancer, and patients who have undergone autologous hematopoietic stem cell transplant (hsct). participants will be randomized 1:1 to either the interventional sync app or to a control app.


Eligibility criteria:
inclusion criteria * must own an iphone 6s or later (with ios 14 or later or willing to update to ios 14+) and be willing to complete surveys on it, per the protocol. * sleep aid usage will be allowed as long as the patient has been on a stable dose for at least 4 weeks prior to enrollment and agrees to continue the same dose during the study. * a response of at least 4 on a 10 point scale (with 0 = not fatigued at all and 10 = extremely fatigued) to the question "how fatigued did you feel in the past week?" * breast cancer population: diagnosed with stage 1-3 breast cancer in the last 10 years, without metastatic disease. chemotherapy or radiation therapy, if indicated, must have been completed at least 3 months prior to enrollment. concomitant anti-her2 therapy and/or anti-endocrine therapy is permitted. * prostate cancer population: undergoing androgen deprivation therapy (adt) for at least three months and are anticipated to remain on adt for the duration of the trial. concomitant additional anti-androgen therapy (e.g., enzalutamide) is permitted. * autologous hsct population: participants must be from the university of michigan blood and marrow transplant program. exclusion criteria * the patient cannot be undergoing chemotherapy at the time of enrollment, but post transplant maintenance therapy that begins after enrollment is allowed. * the patient must have no evidence of disease progression or recurrence. specifically for the prostate cancer population, the patient must have no evidence of disease progression on their current adt regimen at the time of enrollment. * the patient must not be a night shift worker, where night shift is defined as working a significant number of hours (i.e. more than half) between the hours of 11pm and 6am on a regular basis.

Keywords: fatigue light therapy mobile app
surgery versus standardized non-operative care for the treatment of lumbar disc herniations: a canadian trial

Conditions: Lumbar Spine Disc Herniation; Lumbar Radiculopathy

Summary: the objective of this study is to determine if surgery is superior to non-operative care for sciatica caused by a lumbar disc herniation. this study will include patients that have had severe sciatica for greater than 4 months which reflects the wait time of the canadian health care system. this study is an opportunity to make an important contribution to medical science as there is no "top tier" evidence for or against this highly prevalent surgery. although there have been several recent randomized trials in the field, all have been marred by a large number of patient crossing over from non-operative to operative treatment. due to the wait for spine surgery, the canadian system has a built-in delay that prevents such a cross over of patients. this study capitalizes on this unique opportunity to perform a high caliber surgical trial. patients consenting to be in the study will be randomly assigned to expedited surgery within three weeks or standardized non-operative care while they wait on the surgeons list for consultation and then surgery (minimum wait of 9 months). the study will assess pain, function, quality of life, satisfaction, and work status to determine if one treatment is superior.


Eligibility criteria:
inclusion criteria: 1. 18 - 60 years old 2. unilateral, single l5 or s1 radiculopathy (leg pain following dermatomal distribution of l5 or s1) * leg dominant pain over central back pain * positive straight leg raise \<70 degrees 3. mri with corresponding l4-5 or l5-s1 posterolateral disc herniation\* 4. radicular symptom duration greater than 4 months and less than 12 months. may be recurrent if first episode occurred within 12 months and duration of presenting episode is greater than 4 months. 5. agree to possible discectomy exclusion criteria: 1. radiculopathy secondary to foraminal stenosis 2. radiculopathy secondary to intra-foraminal or far lateral disc herniation 3. radiculopathy secondary to lumbar central or lateral recess stenosis not caused by a posterolateral disc herniation 4. previous lumbar surgery at involved level 5. lumbar spondylolisthesis or lateral listhesis at level of disc herniation 6. lumbar scoliosis greater than 10 degrees
digital lifestyle intervention for lung cancer survivors

Conditions: Non-Small Cell Lung Cancer (NSCLC)

Summary: the aim of this study is to assess the efficacy of a digital lifestyle intervention in non-small cell lung cancer (nsclc) survivors on health-related quality of life (hrqol) over three months.

lung cancer survivors suffer from reduced physical and psychological functioning as well as decreased overall health-related quality of life (hrqol) due to cancer symptoms, cancer treatments, and comorbidities. experienced symptoms by lung cancer survivors, such as cancer-related fatigue or dyspnea, persist after active treatment ends. therefore, lung cancer survivors should receive continuous attention regarding their health and hrqol beyond the expected cancer cure. physical activity, healthy nutrition, and breathing/relaxation exercises before, during, and after cancer treatments can increase physical as well as psychological functioning and hrqol. thus, the adhesion to an appropriate healthy lifestyle is crucial and represents an effective adjunctive strategy in the management of lung cancer survivors. most lung cancer survivors, however, are sedentary and fail to meet official lifestyle recommendations, for instance, of the american cancer society or the world cancer research fund/american institute for cancer research (wcrf/aicr). the present project evaluates a mobile application for non-small cell lung cancer (nsclc) survivors that will be used for three months after rehabilitation or treatment has finished. the main foci of the mobile application are physical activity, nutrition, and breathing/relaxation. the contents of the mobile application and the mobile application itself were developed in an iterative co-creation process involving software developers and potential users as well as researchers and clinicians from different disciplines (e.g., physical therapy and nutritional therapy).

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * diagnosis of non-small cell lung cancer (nsclc) * estimated life expectancy of ≥ six months (judged by local investigators/responsible health professionals) * undergoing inpatient or outpatient rehabilitation or completion of planned surgery, chemotherapy, or radiation therapy for nsclc within the past 24 weeks * knowledge of german to understand study material and assessments * access to a cell phone or tablet * written informed consent exclusion criteria: * inability to provide informed consent * inability to participate in the intervention because of physical, cognitive, or safety reasons (judged by local investigators/responsible health professionals)

Keywords: physical activity exercise nutrition breathing relaxation mobile application rehabilitation aftercare
repletion of ergothioneine in patients with kidney failure

Conditions: Esrd

Summary: dialysis removes potentially harmful chemicals from the blood but can also remove potentially valuable chemicals. one potentially valuable chemical called ergothioneine, which comes from our diet, is low in the blood of people receiving dialysis. for this research study, we hope to learn how well a daily ergothioneine supplement will replenish the levels in the blood of people with kidney failure.


Eligibility criteria:
inclusion criteria: * kidney failure receiving hemodialysis or peritoneal dialysis exclusion criteria: * blood transfusion within 90 days * taking supplements which contain ergothioneine
cardiac response to strength training in hypertensive individuals

Conditions: Physical Exercise; Hypertension

Summary: this study aims to determine the acute effects of high and low-intensity strength training on cardiac autonomic control in hypertensive subjects

the present study aims to determine the cardiovascular response in hypertensive individuals between 30 and 60 years old to one session of high and low intensity strength training. participants will undergo a low-intensity strength training including squats, barbell rows, deadlifts and chest presses with a load dynamic of 12 repetitions for 6 sets at an execution speed of less than 55 % of your maximum weight. this is followed by a one-week washout period. subsequently, high intensity strength training is performed with the same exercises but with a load of 6 repetitions for 6 series at an intensity greater than 80% of the maximum repetition speed. the order of the sessions will be random. after each session, blood pressure will be recorded for 24 hours using a holter monitor, which will report pressures during both day and night the results obtained will be determined by the differences in the before and after values. consequently, the behavior of the following variables: 1) heart rate variability, 2) blood pressure and 3) heart rate will determine the final results of this research. the entire study will be carried out at the catholic university of maule, in its kinesiology laboratory.

Eligibility criteria:
inclusion criteria: * participants exclusively diagnosed with hypertension by a medical professional exclusion criteria: * participants with any other chronic medical condition * subjects with any upper or lower limb injury that prevents strength training * subjects with cardiovascular abnormalities other than hypertension
effect of squeezable bottle nasal irrigation device in children with sinusitis

Conditions: Sinusitis

Summary: the purpose of this study is to the effect of squeezable bottle nasal irrigation device with syringe in children with sinusitis in symptom score and satisfaction to nasal irrigation

sinusitis is the one of common diseases in thailand. nasal irrigation has been used as an adjunctive treatment.in previous study shown that buffer hypertonic nasal irrigation have more effective to decrease symptom in patient sinonasal disease when compare to normal saline.until now, there are no clear data comparing the effectiveness on sinonasal symptom of the various devices use in children with sinusitis. the purpose of this study was to compare the effect of squeezable bottle nasal irrigation device with syringe in children with sinusitis in symptom score and satisfaction to nasal irrigation.

Eligibility criteria:
inclusion criteria: 1. age 3-15 years 2. diagnose sinusitis by each of following criteria 2.1 persistent upper respiratory infection symptoms \> or = 10 days 2.2. severe upper respiratory infection symptom with greenish discharge per nose or periorbital swelling 2.3 double sickening of upper respiratory infection symptoms exclusion criteria: 1. patient who has history of penicillin allergy 2. patient who has complication of sinusitis 3. patient with a history of nasal anatomical defects 4. patient who has immune deficiency or primary ciliary dyskinesia

Keywords: nasal irrigation sinusitis children buffered hypertonic saline nasal irrigation device
treatment of post traumatic asymmetrical ankle arthritis using low tibial osteotomy

Conditions: Ankle Arthritis

Summary: evaluation of joint preserving procedure for asymmetrical ankle arthritis regarding the improvement of alignment and its effect on symptoms

the most common cause of end-stage ankle arthritis is trauma. post traumatic ankle arthritis is accepted as the most common cause of ankle arthritis,with reports ranging from 70% to 80% of all ankle arthritis. factors contributing to the development of posttraumatic ankle arthritis are the initial cartilage damage, malreduction ,nonunion, infections, and instability. in a retrospective study,found that 55% of patients with posttraumatic ankle arthritis presented with a varus malalignment, whereas 8% had valgus malalignment 1. nonoperative treatments, including orthotics, wedges, shoe modifications,anti-inflammatory medications, and activity modification,are usually not successful. although the gold standard treatment for ankle arthrosis remains ankle arthrodesis, the significant loss of motion in the ankle is limiting and may lead to the development of arthritis in adjacent joints in the hind foot and forefoot . total ankle replacements (tar) used only in older, low-demand patients with neutral alignment and intact stabilizing ligaments. ankle arthroscopy is indicated in acute, recurring-acute, and chronic ankle pain to detect the possible presence of anterior ankle impingement (bony or soft tissue), syndesmotic injury, osteochondral defects and loose bodies . supramalleolar osteotomy have been used for varus and valgus as well as sagittal and rotational deformities .fibular osteotomy, calcaneal slide osteotomy and osteotomies of the medial arch can be also used as joint preserving procedure. our study is designed for evaluation of the effect of joint preserving procedures in young patient with asymmetrical ankle arthritis.

Eligibility criteria:
inclusion criteria: * 1-age 18-60 years. 2-symptomatic ankle osteoarthritis varus or valgus ankle deformity on x-ray with asymmetrical ankle arthritis. 3-patient had failure of conservative treatment. 4-patient with clinical symptoms,such as pain with walking and limitation of daily and recreational activities. exclusion criteria: * 1- end-stage arthritis 2- severe hindfoot instability that cannot be stabilized 3- severe vascular or neurologic deficiency in the affected extremity 4 - neuropathic disorders (eg, charcot foot). 5- diabetes,chronic liver disease,renal failure 6- smoking, and rheumatic disease. 7- condition altered bone quality (due to medication, large cysts,osteoporosis and osteopenia )