Kornimate/medical-research-clean huggingface dataset:
diagnosis of periprosthetic joint infection and the common pathogens, durg-resistance in periprosthetic joint infection

Conditions: Arthropathy of Hip; Arthropathy of Knee

Summary: this retrospective study aims to improve the diagnosis of pji as well as to identify microorganisms causing periprosthetic joint infection (pji) and the drug-resistant spectrum

160 patients who underwent revision or re-revision total hip or knee arthroplasty for different reasons in our institution were recruited from august 2013 to august 2016. 80 patients meet the criteria of pji from the muscle and skeletal muscle association (msis) are divided to the infection group, another 80 patients are divided into the non-infection group. medical and demographic data were recorded. collected lab examinations included blood routine test, c-reactive protein (crp), erythrocyte sedimentation rate (esr), synovial leukocyte counts, receiver operating characteristic curve-area under curve (roc-auc) analysis will be used to evaluate the specific and sensitivity of diagnosis index. moreover,microorganisms isolated from periprosthetic tissues and articular fluid. postoperatively, the prosthesis was sent for ultrasound sonication. the sonicate extraction, implant surrounding tissue and synovium were sent for microbiologic culture, and the implant-surrounding-tissue were also sent for pathological examination. the isolated strains and drug-resistance rate for each bacterium for different antibiotics were presented.

Eligibility criteria:
inclusion criteria: * patient who underwent revision or re-revision total hip or knee arthroplasty for different reasons in our institution exclusion criteria: 1. patients who refused to join the trial group; 2. revision total hip/knee replacement for periprosthetic fracture; 3. patients who missed some of important examination; 4. revision total hip/knee replacement for metal sensitivity; 5. revision total hip/knee replacement for the last period of second-stage revision; 6. patient who underwent revision with ra or other inflammatory disease.

Keywords: periprosthetic joint infection
pascal trabeculoplasty

Conditions: Open-Angle Glaucoma

Summary: argon laser trabeculoplasty (alt) with 100 ms pulses is an effective therapy for lowering intraocular pressure (iop). similar reductions in iop have been achieved using ns (slt) and microsecond (mlt) pulses, which produce less thermal damage to trabecular meshwork (tm). lack of clinically visible changes may make the accurate alignment of subsequent pulses difficult. we describe a novel technique - patterned laser trabeculoplasty (plt) using the pascal photocoagulator system, and its preliminary evaluation in patients with open angle glaucoma.


Eligibility criteria:
inclusion criteria: * 18-year-old patients * uncontrolled open angle (shaffer iv) * no previous surgical trabeculoplasty or glaucoma surgery exclusion criteria: * patients not willing to participate * angle-closure glaucoma * no clear optical media
real-world diagnostic effectiveness of artificial intelligence algorithm in diabetic retinopathy screening

Conditions: Diabetic Retinopathy

Summary: recently, artificial intelligence algorithm has made great progress in the prediction of diabetic retinopathy based on fundus images，showing very high sensitivity and specificity. however，the real-world diagnosis effectiveness of deep learning model is still unclear. this study is designed to evaluate the clinical efficacy of such an algorithm in detecting referable diabetic retinopathy.

this prospective clinical study is designed to evaluate the real-world diagnostic performance of an ai model in detecting referable diabetic retinopathy (rdr, defined as more than mild npdr), by evaluating its sensitivity and specificity compared to the clinical reference standard- seven-field stereoscopic photography. the subjects enrolled in this study are patients with t1dm or t2dm. qualified color fundus images and seven-field stereoscopic photography images of each eyes of the subject are taken. the fundus images are graded for rdr by the algorithm under test, and seven-field stereoscopic photography images of the same eye are graded by ophthalmologist, which serving as the gold standard to compare the algorithm performance against. the trial plans to enroll 1000 subjects. with a 95% confidence interval, the sensitivity is expected to be at least 87% whereas the specificity at 89% or above. the quality of fundus images are assessed according to the national dr screening imaging and grading guideline published by chinese ophthalmological society and chinese medical doctor association in 2017. the grading of rdr is based on the national dr clinical diagnosis and treatment guideline published by chinese ophthalmological society in 2014. a brief overview of the clinical protocol is as follows: candidate recruiting phase: recruiting qualified participants; clinical phase: imaging and diagnosing by ai and ophthalmologist ; statistical analysis phase: comparing two outputs; closing phase: final report and archiving

Eligibility criteria:
inclusion criteria: 1. subject must understand the study, participate voluntarily, and has signed informed consent 2. age 18 or older, no limitations on gender identity 3. patients with type 1 or type 2 diabetes. exclusion criteria: 1. subjects diagnosed with eye diseases other than diabetic retinopathy 2. subjects diagnosed with macular edema, severe non-proliferative retinopathy, proliferative retinopathy, radioactive retinopathy or retinal vein obstruction. 3. pregnant woman, subjects with mydriatic allergy, unclear refractive medium, family history of glaucoma, or diagnosed as narrow angle 4. subjects with a history of laser therapy, retinal surgery or anti-vascular endothelial growth factor injection 5. subjects currently participating in another ophthalmic research, receiving ophthalmic research products. 6. subject who is photo-sensitivity or taking medication that causes photosensitivity 7. subjects received photodynamic therapy recently
the beacon trial: diagnostic tools for breast lymphedema after treatment for breast cancer

Conditions: Breast Edema; Breast Lymphedema; Lymphedema, Breast Cancer; Lymphedema

Summary: the goal of this observational study is to learn if participants agree to take part in the study, if the methods we are using for the study are feasible for the participants and the researchers, and to study how well two tools (tissue dielectric constant and ultrasound) measure breast edema after breast conserving surgery for breast cancer. participants who agree to be in the study will be asked to come in for one appointment of approximately two hours. all data will be collected during this one visit. participants will be asked to fill out two questionnaires regarding their symptoms, and one questionnaire regarding their surgical scar. the research staff will conduct a clinical examination, measure breast edema using ultrasound and tissue dielectric constant, measure arm volume with the perometer and fluid with the sozo, and take photographs of both breasts.

the goal of this observational study is to learn if the study protocol is feasible, if we can accrue participants easily, and to determine how well two tools (tissue dielectric constant and ultrasound) identify breast edema after breast conserving surgery for breast cancer. participants will be asked to attend one appointment in which all data will be collected. this will include questionnaires regarding symptoms, clinical examination, measurement of breast edema using two tools (ultrasound and tissue dielectric constant), measurement with the perometer and sozo, and clinical photographs.

Eligibility criteria:
all participants must meet the following inclusion criteria: * be a female between the ages of 18 and 85 years. * have undergone breast conserving surgery +/- ln removal (sentinel lymph node biopsy (slnb) or axillary lymph node dissection (alnd) * have no residual cancer in the breast after definitive breast surgery * have been treated with radiation therapy and have completed breast cancer treatment (excluding herceptin and hormonal treatments) at mgh greater than or equal to 3 months ago. * be able to read and understand english * understand the proposed study and be willing and fully able to comply with the study procedures * be a willing participant and be capable of giving and has given informed written consent for entry into the study exclusion criteria participants will be excluded if they: * have bilateral bc * have metastatic or inflammatory bc * will be excluded from the sozo measurement of the study if they have implanted cardiac devices or neurostimulators * have any medical condition that may result in breast swelling; * uncontrolled congestive cardiac failure, * arteriovenous haemodialysis, * current infection or cellulitis of either breast. * be pregnant or currently breast feeding. * have a known over-active thyroid or known benign thyroid tumour

Keywords: breast edema breast swelling breast lymphedema breast edema screening breast swelling after breast cancer
role of the gut sweet taste receptor in the secretion of glucagon-like peptide-1 and peptide yy

Conditions: Taste Disorder, Primary, Sweet

Summary: the purpose of this study is to determine the functional significance of sweet taste receptors in the secretion of gi satiation peptides by using a specific sweet taste receptor antagonist to block sweet taste perception in the gastrointestinal tract.

there is strong evidence that taste signaling mechanisms identified in the oral epithelium also operate in the gut. it is suggested that open-type enteroendocrine cells directly sense nutrient via alpha-gustducin coupled taste receptors to modulate the secretion of glucagon like peptide-1 (glp-1) and peptide yy (pyy). several nutrient responsive g-protein coupled receptors have been identified in the human gut, including the sweet taste responsive t1r2/t1r3 heterodimer, the amino acid/umami responsive t1r1/t1r3 as well as gpr120 for unsaturated long-chain free fatty acids.the functional significance of sweet taste receptors in the secretion of glp-1 and pyy will be determined by intraduodenal perfusion of glucose (i) or a mixed liquid meal (ii) with or without lactisole (450 ppm) in a double blind, 5-way crossover trial including 10 healthy subjects.

Eligibility criteria:
inclusion criteria: * healthy subjects * bmi of 19.0-24.5 * age 18-40 * stable body weight for at least 3 month exclusion criteria: * smoking * substance abuse * regular intake of medication * medical or psychiatric illness * gastrointestinal disorders or food allergies

Keywords: t1r2/t1r3 gastric emptying gut lactisole nutrient sensing
tk-based suicide gene therapy for hepatocellular carcinoma

Conditions: Carcinoma, Hepatocellular

Summary: the purpose of this study is to determine whether activation of a prodrug after intratumoral gene transfer is safe in humans, and to determine dose levels for further clinical development.

the study is a phase i clinical trial evaluating the intratumoral injection of defective adenovirus containing hsvtk (the thymidine kinase of herpes simplex virus), in patients with advanced hepatocellular carcinoma that were not amenable to curative therapy. the study was conducted in a single center in spain. five consecutive cohorts of two patients received increasing doses of the vector by intratumoral injection and equal doses of either intravenous ganciclovir or oral valganciclovir. the dose received by each consecutive cohort of patients was progressively higher according to a prefixed scale.

Eligibility criteria:
inclusion criteria: * unequivocal diagnosis of hepatocellular carcinoma according to histological confirmation or easl-aasld criteria * contraindication for surgical treatment of the disease * detectable disease by imaging * ability to give informed consent and to express the willingness to fulfill protocol requirements during the study exclusion criteria: * current pregnancy or breast-feeding * acute infection * positive anti-hiv antibodies * hematologic alterations not attributable to hypersplenism, or in any case, intense neutropenia and thrombocytopenia, defined as neutrophil count lower than 0,5/pl or platelet count lower than 20/pl * participation in other clinical trial during the previous month

Keywords: primary liver cancer, hepatoma
ocupapp: occupational self-analysis intervention through an mobile application

Conditions: Anxiety Disorder; Depressive Disorder; Occupational Therapy; Mobile App

Summary: the goal of this clinical trial is to test the effectiveness of the use of mobile application ("ocupapp") to generate a personal self-analysis about meaningful activities in which adults between the ages of 50 and 70 with anxiety and subclinical depression participant. a randomized study will be carried out comparing the effects of the use of the application "ocupapp" with a control intervention on the quality of life related to health, mental health, frequency of participation on meaningful activities, and perceived occupational balance.

ocupapp is a mobile application developed within the research team, which aims to promote occupational self-analysis in adults with depression and/or anxiety. the mobile application allows to offer feedback to participants about the meaning of the activities they carry out daily and their perception of occupational balance, which generates a subjective self-reflection that can lead to the implementation of some personal changes in their weekly routine. for this, the person must register the activities they carry out throughout a week and mark each one of them with a punctuation related to the meaning of the following dimensions: identity, pleasure, competence, importance and value of the activity by other people. the punctuation give will be on a likert-type scale from 1 to 5. the application also allows to collect other information such as where the activity takes place, its duration, and the people with whom it is carried out. also, at the end of the week, the application will ask users about their perceived occupational balance. all the information registered in the mobile application will be returned to the person in a dynamic and understandable way. based on this, the person can establish two goals to accomplish. in this sense, ocupapp will offer personalized recommendations based on the objectives to be achieved related to the dimensions of meaning.

Eligibility criteria:
inclusion criteria: * have a smarthphone and know how to use mobile apps to exchange information. * have a low or moderate depression (dep 5 \<= 4) or low or moderate anxiety (anx5 \<= 3) or dep5 or anx5 =3). exclusion criteria: * have a serious mental illness or psychosis. * have a diagnosis of dementia * have language problems or cognitive alterations that doesn't allow comprehension of assessment tools.
stress, emotion regulation, and alcohol in women veterans

Conditions: Alcohol Use Disorder; Post Traumatic Stress Disorder

Summary: the purpose of the study "stress, emotion regulation, and alcohol in women veterans" is to learn about the effects of negative emotion and stress on behavior (including alcohol use) among women veterans, including women with and without posttraumatic stress disorder. additionally, the study looks at whether a woman's use of emotion regulation techniques changes the association between stress or negative emotion and behavior. lastly, the study examines how women's reactions to stress, and the effects of stress, vary across the menstrual cycle - depending on the level of circulating hormones.

aims for the current study are two-fold: 1. conduct a randomized trial testing the effects of an emotion regulation skill (cognitive reappraisal) on stress-induced drinking among women with alcohol misuse and varying levels of co-occurring ptsd; 2. examine whether progesterone levels and/or severity of co-occurring ptsd - factors which impact women's stress reactivity and emotion regulation - moderate the effectiveness of the cognitive reappraisal in reducing stress-induced drinking. the proposed study will combine experimental, in-person sessions with daily self-report data from the veterans to assess the effect of cognitive reappraisal on alcohol craving, cognitive (inhibitory) control, physiological arousal (hrv), and alcohol use. participation will take place across a period of at least 35 days, to encompass an entire menstrual cycle. all participants complete all sections of the study - the experimental sessions and the longitudinal (35-day) data collection.

Eligibility criteria:
inclusion criteria: * current alcohol misuse, defined as scoring 3 or higher on the audit-c * if using other illicit substances, alcohol is their primary substance of use * alcohol use in the past 45 days * able to write and speak in english * served in the u.s. military * willing to provide blood samples at laboratory sessions to assay hormone levels and take urine ovulation tests at home exclusion criteria: * psychotic symptoms or uncontrolled bipolar disorder (screened for during session 1 using scid-5 screening modules) * brain damage or were in an accident that affects ability to complete the computerized task * current (past 3 months) active suicidal ideation or intent * current pregnancy

Keywords: alcohol use disorder women veterans endocrinology cognitive reappraisal microintervention progesterone posttraumatic stress disorder psychophysiology heart rate variability
hypofractionated radiotherapy for lung cancer

Conditions: Lung Cancer

Summary: the purpose of this trial is to pilot reducing the duration of radiation treatment for lung cancer patients from 6 to 5 weeks using tomotherapy. specific patient doses will be based on tumor volume being treated. modeling has shown that increased biologically effective dose (bed) to tumors can be achieved by shortening the radiation delivery schedule and increasing the dose per fraction. this requires decreasing the total dose to hold lung toxicity constant at each dose per fraction level. this is a major paradigm shift in the treatment in this disease and is projected to result in significant improvements in patient outcome as well as a substantial cost savings.


Eligibility criteria:
inclusion criteria: * thoracic neoplasm requiring at lest 60 gy conventional radiotherapy exclusion criteria: * prior bleomycin or gemcitabine chemotherapy * prior thoracic radiotherapy
postoperative quality of recovery after transurethral resection of the bladder

Conditions: Urinary Bladder Neoplasms; Transurethral Resection of the Bladder; Postoperative Recovery

Summary: transurethral resection of the bladder (turb) is often performed as an outpatient procedure so high-quality postoperative recovery is particularly important. the aim of this study is to compare postoperative quality of recovery after spinal anesthesia (sa) and general anesthesia (ga) for transurethral resection of the bladder.

after written informed consent is obtained seventy patients aged 18-80 years, asa (american society of anesthesiologists) physical status class i-iii scheduled for turb will be randomly assigned to either spinal anesthesia or general anesthesia. spinal anesthesia will be performed with 12.5 mg of bupivacaine mixed with 25 mcg of fentanyl. general anesthesia will be performed with propofol and fentanyl and maintained with sevoflurane, without use of neuromuscular blocking agents. quality of recovery 40 questionnaire (qor-40) administered before and 24 hours after surgery will be used for assessment of postoperative recovery.

Eligibility criteria:
inclusion criteria: * transurethral resection of the bladder * age 18 to 80 years * asa i-iii exclusion criteria: * contraindications for spinal anesthesia * chronic pain with use of opioids in the last week * psychiatric disorders * allergy to medications used in the study
advanced mr techniques for breast cancer detection

Conditions: Breast Cancer

Summary: evaluation of advanced mri acquisition techniques (perfusion and diffusion) to detect breast cancer. two mr advanced sequences will be added to a standard breast mri protocol for evaluation purpose.

this is a prospective monocentric longitudinal study on a consecutive population of patients who require breast mri as part of their course of care in the radiology department of the tenon hospital (3t mri). the standard protocol for breast mri routinely performed in tenon hospital consists of a set of mr acquisitions performed with contrast agent injection. the research consists of adding perfusion and diffusion sequences to the regular mr protocol. the addition of these sequences does not require a new injection of contrast medium. diagnosis of lesions after the breast mr exam will be performed using standard mr sequences as usual. according to the recommendations of sifem, the final diagnosis of the lesions will be made either by histological analysis of a biopsy performed as part of the patient's standard care pathway, or during patient's follow-up if a biopsy is not indicated (up to two years after breast mr exam). the research will focus on evaluating the sensitivity and specificity of perfusion mri sequence with or without diffusion mri sequence compared to the sensitivity and specificity of the standard protocol. for the perfusion sequence, the following data will be extracted: qualitative (shape of the contrast curve), semi-quantitative (elevation slope and asymptote of the curve) and quantitative by compartmental modeling (tissue perfusion, blood volume fraction, surface capillary permeability). for the diffusion mri, the extraction of quantitative data such as cda, ivim and kurtosis will be performed and parametric maps, cellularity maps and an assessment of lesion heterogeneity will be calculated. a correlation will be made with histological, immunohistochemical and molecular results of cancers following biopsy

Eligibility criteria:
inclusion criteria: * adult patient * patient who has signed a consent form to participate in the study * affiliated patient or beneficiary of a social security scheme * patient with an injected breast mr exam planned as part of her care pathway. exclusion criteria: * patients under guardianship or curatorship * pregnant or breastfeeding patients * patients with contraindications to realization of an mr exam and an injected mr exam

Keywords: mri breast cancer screening innovative sequences