Kornimate/medical-research-clean huggingface dataset:
alternate day vs. daily iron supplementation in iron depleted women

Conditions: Iron-deficiency; Iron Deficiency Anemia

Summary: iron deficiency (id) with or without anemia is a major public health problem worldwide, especially in women of reproductive age. iron supplementation can be an effective strategy to prevent and treat id and iron deficiency anemia (ida). recent studies suggests that giving oral iron every other day would be an optimized dosing regimen with maximized absorption and a lower incidence of gastrointestinal side effects compared to consecutive day dosing. long-term trials in which participants and investigators are blinded to the dosing interval with iron status and gastrointestinal side effects as study outcomes are needed.


Eligibility criteria:
inclusion criteria: * female, 18 to 45 years old, * sf levels \<25 μg/l, * hb levels ≥ 11 g/dl * normal body mass index (18.5-25 kg/m2), * in possession of a mobile phone on which the study app can be loaded, * signed informed consent, * not mandatory (only for subgroup analysis): having participated in a former stable iron isotope study in our laboratory between 1-5 y ago exclusion criteria: * elevated crp \> 5 mg/l, * any metabolic, gastrointestinal, kidney or chronic disease (self-reported) affecting iron metabolism, * continuous/long-term use of medication, which may interfere with iron absorption, gut physiology and iron metabolism, * consumption of additional iron supplements over the study period, * consumption of iron supplements since screening, * difficulties with blood sampling, * known hypersensitivity or allergy to iron or placebo capsules in the given amount (ferrous sulfate, mannitol, silica) * pregnancy, breastfeeding * women who intend to become pregnant during the course of the study, * known or suspected non-compliance, drug or alcohol (more than 2 drinks/day) abuse, * smokers (\> 1 cigarette per week), * participant is likely to be absent on one the study appointments, * inability to follow the procedures of the study, e.g. due to language problems, self-reported psychological disorders, etc. of the participant.

Keywords: iron supplementation dosing regimen iron sulfate women of reproductive age
glutamine supplement in melas (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome

Conditions: MELAS Syndrome

Summary: the purpose of this study is to assesses the efficacy of oral supplementation with glutamine over three months on several amino acids and lactate concentration measured in cerebrospinal fluid and cerebral lactate measured by magnetic resonance spectroscopy.

mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (melas) syndrome is a genetically heterogeneous disorder. the most common mutation is in the mtdna gene mt-tl1 encoding the mitochondrial trnaleu (uur). for understanding the development of seizures in patients with mitochondrial disease, a study has recently emphasized the deficiency of astrocytic glutamine synthetase, creating a disinhibited neuronal network for seizure generation. the investigators propose to evaluate nine patients with mitochondrial dna mutation and melas. patients will receive oral supplementation with 10-15 g/day of glutamine (adjusted for weight and plasma concentrations). the primary outcome measures several amino acids (including glutamine) and lactate concentration measured in cerebrospinal fluid and cerebral lactate measured by magnetic resonance spectroscopy.

Eligibility criteria:
inclusion criteria: * the diagnosis of melas syndrome is based on medical history (lactic acidosis, stroke-like episodes, and encephalomyopathy). * subjects have to be clinically stable for more than six months after any stroke-like episodes. * all subjects have to be genetically confirmed. exclusion criteria: * subjects harboring a melas-related pathogenic mtdna mutation, no fulfilling the complete diagnostic criteria for the melas phenotype.

Keywords: melas glutamine oral supplements lactate cerebrospinal fluid magnetic resonance spectroscopy
leveraging virtual care strategies to improve access and treatment for individuals with alcohol use disorders

Conditions: Alcohol Use Disorder

Summary: the purpose of this research study is to test new technology-driven programs to see if they might help people manage their health and health behaviors related to alcohol use and well-being. the programs focus on getting to know what's important to participants, reviewing or setting goals, and using different skills and behaviors to manage health. the study will help researchers learn about ways to deliver health information in a way that is useful and interesting.


Eligibility criteria:
inclusion criteria: * aud * past month heavy alcohol use * internet access * phone access * able to provide informed consent exclusion criteria: * inability to speak or understand english * conditions precluding informed consent or understanding of intervention or assessment content * recent aud treatment * history of or at risk for complex alcohol withdrawal * involvement in another ongoing study for alcohol/mental health/substance use treatment * current cancer diagnosis/ currently receiving cancer treatment (other than skin cancers) * pi discretion

Keywords: telehealth
effect of complex decongestive therapy, cryotherapy and kinesio taping in patients with post-mastectomy lymphedema: a randomized control trial

Conditions: Breast Neoplasms

Summary: to examine the efficacy of complex decongestive therapy (cdt), cryotherapy and kinesio taping (kt) in patients with post-mastectomy lymphedema

sixty women diagnosed clinically by physician as post-mastectomy lymphedema, suffered from grade 2 and 3 lymphedema based on clinical investigations and their ages between 40 and 60 years were randomly assigned in single pre - post measurement study. they divided randomly into three groups of equal size (a, b \& c). the three groups received cdt program, group (a) (n=20) received cdt only, group (b) (n=20) received cryotherapy and group (c) (n=20) received kt

Eligibility criteria:
inclusion criteria: patients aged between 40 to 60 years. they were grade 2 and 3 lymphedema. they had more than 2 cm difference at circumference measurement. they had unilateral arm lymphedema post-mastectomy. they had completed chemotherapy and radiotherapy. exclusion criteria: skin infection. current ischemia. systemic edema due to impaired heart, kidney and liver function. current metastases. venous thrombosis.

Keywords: complex decongestive therapy; cryotherapy; kinesio taping; lymphedema; post-mastectomy
comparison of efficacy of phenytoin with levetireacetam for the management of children with status epilepticus

Conditions: Status Epilepticus

Summary: the purpose of studyis to compare the efficacy of phenytoin with levetiracetam for the management of children with status epilepticus.study performa consists of demographic variables,exclusion criteria,history of epilepsy and efficacy achieved or not.

after getting informed consent 244 children with status epilepticus will be randomly classified into two groups.one group will receive levetireacetam and other group will be given phenytoin and their efficacy will be compared by observing them for breakthrough fits for next 48 hours.

Eligibility criteria:
inclusion criteria: * childen of age less than 12 years either gender admitted in pediatric emergency with status epilepticus exclusion criteria: * children already taking either of trial drug or failed treatment with either of trial drug.children with comorbid conditions

Keywords: status epilepticus, children, phenytoin, levetireacetam
effects of piomi on oral feeding of the premature infants

Conditions: Feeding Disorder Neonatal

Summary: randomized controlled clinical trial aimed at evaluating the effects of the "premature infant oral motor intervention" method on the oral feeding skills of the premature infants.

numerous evidences emerge from the literature review on the usefulness of the piomi method to improve food skills in the premature infant. the goal of this study is to evaluate the effects of the piomi method by adding the gustatory stimulation to the original protocol.

Eligibility criteria:
inclusion criteria: * gestational age at birth between 25-33 weeks; * clinical stability; * possible presence of nasogastric or oro-gastric tube; * non-invasive respiratory support (oxygen, high flows) exclusion criteria: * gestational age \ 33 weeks * absence of clinical stability * invasive respiratory support (cpap) * previous surgical interventions * ongoing infections * congenital and / or chromosomal diseases * brain, metabolic, cardiac, gastrointestinal diseases * presence of bronchopulmonary dysplasia
physiologic effect of spices ingestion

Conditions: Healthy

Summary: human studies have shown that capsaicin, a compound extracted from chilly peppers, can stimulate certain physiologic functions (for example, energy expenditure, thermogenesis, lipid oxidation, heart rate, etc.). the purpose of this study is to measure the impact of ingesting various spicy molecules on a set of physiologic parameters compared to a placebo. the molecules were selected for their different sensory properties. the results of this study will allow us to implement an effective method for measuring the impact of ingesting spices on certain body functions (for example, metabolism and autonomic nervous system activity). this study will also allow us to identify the beneficial properties of eating certain spices.

primary objective and outcome: the main objective of this study is to establish a methodology to evaluate the acute impact of spice ingestion on metabolism and autonomic nervous system activity. primary outcomes: impact of the spice on autonomic nervous system activity: power spectra analysis on heart rate variability (hrv) changes during the 90 post ingestive minutes (measured by ecg). impact of the spice on metabolism: energy expenditure changes during the 90 post ingestive minutes (measured by indirect calorimetry). as secondary outcomes blood pressure changes and facial temperature changes on specific area (nose, cheeks and forehead) will be evaluated. substrate oxidation (carbohydrates and fat utilization) and the respiratory quotient (rq) will be calculated using indirect calorimetry data for energy expenditure measure.

Eligibility criteria:
inclusion criteria: * healthy * bmi: 19-25 kg/m2, ≥ 60 kg body weight * moderate spicy food eaters * having signed the informed consent. exclusion criteria: * any gastrointestinal disorder * subject sensitive or not used to eat spicy food * smokers * subject with beard or mustache * abnormal thyroid function * intake of medication that could affect body weight and/or energy expenditure * weight loss \> 5% in the last 3 months * under antibiotics or regular treatments (medical or nutritional program) affecting body weight, appetite, energy expenditure, lipid-lowering, hypertension or inflammation or glucose control for the last 3 months or taking hormone replacement therapy * history of allergy * physical activity level \> 300 min of moderate or intense exercise per week * have a alcohol consumption higher than than 1 drink/day * consumption of illicit drugs * subject who cannot be expected to comply with the study procedures, including consuming the test products * currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study

Keywords: heart rate variability resting energy expenditure facial thermography blood pressure spices ingestion
school intervention with daily physical activity and healthy food for students with an intellectual disability.

Conditions: Weight Loss; Food Habits; Mental Retardation

Summary: a whole of school intervention with daily physical activity and healthy food for students with intellectual disabilities. the aim is to provide plenty of concrete examples of healthy life style choices and using school personnel and peers as role models. this will presumably result in healthier weight, better fitness and not least in new familiar healthy habits.

youth with an intellectual disability are reported more sedentary and more often overweight than non intellectual disability youth. cardio metabolic risk factors are observed more frequent and at an earlier age among young people with intellectual disability. the school reaches all students and they spend the main part of their day in the school milieu hence examples of healthy lifestyle can be provided there. this intervention increased physical activity with daily scheduled physical activity. at least one lesson each week was at the gym. food provided in the school environment was considered from content of sugar and fat and ónly healthy food choices was available at school. this included all school activities, both in the school area and on school activities out in the community. it included home economic lessons as well as the school cafeterias supply and school lunch content. to increase vegetable intake a special designed plate was used for lunch according the "plate model". in addition, the plate model was one theme during art class.

Eligibility criteria:
inclusion criteria: * mild/moderate intellectual disability * students at the upper secondary schools for intellectual disability students exclusion criteria: * severe intellectual disability * obesity related syndromes * major physical disabilities

Keywords: learning disability blood lipids cardio metabolic risk factors upper secondary school for learning disability students adolescents cardio respiratory fitness absorptiometry photos
glyceryl trinitrate ointment vs posterior tibial nerve stimulation in the treatment of anal fissure

Conditions: Pain

Summary: a prospective randomized study was performed. compliance with the treatment and healing rate of chronic anal fissure in patients receiving glyceryl trinitrate ointment (gto) and subjects undergoing percutaneous posterior tibial nerve stimulation (pptns) were evaluated .

patients were randomly assigned to experimental and control groups: those patients undergoing pptns (experimental group - eg) and those receiving glyceryl trinitrate ointment (control group - cg). treatments: glyceryl trinitrate ointment (gto): commercially available aluminium tubes containing 0.4 glyceryl trinitrate ointment (rectogesic, prostrakan group, galashiels, uk) were purchased from pharmacies. the dosage for all the patients was 375 mg of ointment (containing 1.5 mg of glyceryl trinitrate), applied with a gloved finger to the distal anal canal, every 12 hours for an 8-week period. pptns: the urgent pc neuromodulation system® (uroplasty, minnetonka, mn, usa) was used. subjects underwent one 30-min session 2 days per week for 8 consecutive weeks in an outpatient clinic. patients were placed in the supine position without anesthesia. pptns was delivered using a needle electrode that was inserted 3-4cm cephalad and 2 cm posterior to the medial malleolus at a 60º angle towards the ankle joint to a depth of approximately 0.5-1cm. successful placement was confirmed by the presence of electric sensation 5 cm above and below the insertion site or a digital plantar flexion. pptns was undertaken at the highest amplification (0-20 ma) at a frequency of 20 hz, causing neither a motor response nor pain. compliance with the treatment and healing rate of chronic anal fissure was investigated.

Eligibility criteria:
inclusion criteria: * persistent anal fissure after the failure of hygienic and dietary measures over at least a 6-week period exclusion criteria: * associated anal pathologies * intestinal inflammation disorders * fissures secondary to underlying diseases * patients with previous history of headaches
pulmonary function tests in children and adolescents with end stage renal disease on regular hemodialysis

Conditions: End Stage Renal Disease on Dialysis

Summary: to study pulmonary function tests in children with esrd on regular hd and its correlation with dialysis duration and other various risk factors

end stage renal disease (esrd) is irreversible and progressive disease which characterized by irreversible loss of kidney function. the esrd is terminal and final pathway that resulted eventually in most of the patients suffering from medical problems affecting their renal function. patients with esrd need renal replacement therapy once they are established the esrd stage via and that may either be achieved by dialysis (hemodialysis or peritoneal dialysis) or need kidney transplantation so as to be able to keep functioning normal renal life. there was an observed increase in the morbidity and mortality in esrd patients because of the presence of the renal replacement therapy (hd or renal transplantation). despite that esrd may appear as a single organ dysfunction, it also affects multiple organs with variable and numerous complications which resulted in multi-organ dysfunction so the systemic complications presented in esrd patients are very important . one of the most important of these complications is the respiratory system dysfunction related to renal dysfunction which is a very common complication in esrd patients . rising in the blood urea level, may be the cause that affects the respiratory system in the form of pulmonary edema, pleural effusion and acute respiratory distress syndrome (ards) . dialysis may have beneficial effects at least in the initial stages of some respiratory disorders among ckd patients without primary lung disease. it may lead to improvement of respiratory symptoms and even pulmonary function test values.

Eligibility criteria:
inclusion criteria: * children and adolescents(more than seven years old and less than 18 years old) with esrd on regular maintenance hd for at least six months before inclusion on the study exclusion criteria: * patients with age less than seven years or more than 18 * patients with congenital heart diseases * patient with bronchial asthma * patient with musculoskeletal disorders * patient who were unable to cooperate
preoperative intravenous omega 3 fatty acids administration in valvular surgery patients

Conditions: Valvular Surgery; Inflammation

Summary: the perioperative administration of n-3 fatty acids has been shown to lead to favorable effects on outcome in patients with severe surgical interventions by lowering the magnitude of inflammatory response and by modulating the immune response. to the investigators' knowledge, no study with preoperative administration of intravenous (iv) omega 3 fatty acids as a part of total parenteral nutrition (tpn) or monotherapy with it to demonstrate its effects on inflammatory and immune response has been conducted. so, this study has been planned to judge the inflammatory response of preoperative monotherapy with iv omega 3 fatty acids in elderly patients undergoing valvular surgery considering the hyperinflammation associated with this type of surgery in elderly patients.


Eligibility criteria:
inclusion criteria: 1. adult male or female patients undergoing valvular surgeries 2. age 18-50 years 3. the patients who give written informed consent exclusion criteria: 1. refusal to participate in the study 2. allergy to any of the constituents of nutritional products 3. hiv positive patients, patients with primary diagnosis of hypertriglyceridemia, patients on long term steroid therapy and cycloxygenase inhibitors (more than 3 months) 4. severe cardiac disease, hepatic disorders (total bilirubin \> 1.5 times the upper limit of normal), psychiatric disorders likely to affect compliance, severe hemorrhagic disorders, stroke, embolism 5. uncontrolled severe renal failure (serum creatinine \> 2 mg/dl) without dialysis/hemofiltration 6. pregnant or nursing women 7. participation in any other clinical trial within the last 2 months

Keywords: ivfo inflammation valvular surgery inflammatory status infectious complications
video information provider for hiv-associated non-aids (vip-hana) symptoms

Conditions: HIV (Human Immunodeficiency Virus); AIDS (Acquired Immunodeficiency Syndrome)

Summary: the purpose of this study is to use technology to improve symptom status and ultimately improve patient centered outcomes in people living with hiv/aids (plwha). the primary purpose of the intervention (vip-hana) is to improve symptom status. the investigators hypothesize that vip-hana will improve symptom frequency and intensity.

as plwha age, they are developing chronic illnesses and co-morbid conditions that are often seen in older hiv negative patients. hana conditions (e.g., cardiovascular disease, liver disease, diabetes, and asthma) are becoming more common as plwha age. an individual's ability to identify and self-manage symptoms of hiv illness has been shown to improve patient outcomes and quality of life. the investigators will develop and pilot test the video information provider (vip), a web application (app) that delivered hiv-related symptom self-care strategies for plwha for 13 common (non-hana) hiv/aids symptoms. there is a need to identify the symptom experience of plwha with hana conditions. the aim is to compare the efficacy of vip-hana to a control arm for ameliorating symptom frequency and intensity and secondary health outcomes in 100 plwha with hana conditions over 6 months.

Eligibility criteria:
inclusion criteria: 1. hiv+ 2. age 18 or over 3. able to read and respond in english 4. reside within the us 5. willing to participate in an online survey. exclusion criteria: 1. hiv-negative 2. under age 18 3. unwilling to provide key data (i.e., age, information about symptoms) on the online survey.

Keywords: hiv/aids health management app hiv/aids symptoms
effects of oral fruit concentrate supplementation on cardiometabolic parameters.

Conditions: Metabolic Syndrome

Summary: cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. dietary interventions to improve cardiometabolic health are highly sought after as they possess less risk than pharmacological drugs. anthocyanins, found in high quantities in both tart cherries and blueberries are powerful antioxidants, that are potentially capable of improving cardiometabolic dysfunction. however, to date, no research has explored the cardiometabolic responses to tart cherry and blueberry supplementation. therefore, the primary purpose of the proposed investigation is to test the ability of oral tart cherry and blueberry supplementation to improve cardiometabolic parameters in healthy individuals.


Eligibility criteria:
inclusion criteria: * healthy * 18 years of age and above * non-smoker * bmi \< 30 * able to give informed consent exclusion criteria: * pregnancy * diabetes or any other metabolic/ uncontrolled hypertensive conditions * food allergies to cherries or blueberries * habitual consumption of blueberries/ cherries and/or blueberry/ cherry products * not regularly taking medication or antioxidant supplements