Kornimate/medical-research-clean huggingface dataset:
more intensive cardiac rehabilitation programs in less time

Conditions: Acute Coronary Syndrome

Summary: to determine if an intensive cardiac rehabilitation program with periodic reinforcements improve the compliance/adherence to secondary preventive measures (physical exercise, mediterranean diet, tobacco abstinence, pharmacological treatment) after an acute coronary syndrome with or without st segment elevation versus an standard cardiac rehabilitation program


Eligibility criteria:
inclusion criteria: * signed informed consent * equal or older 18 years old * acute coronary syndrome with or without st elevation within last two months * being able to do physical exercise * being able to understand the educative sessions * being able to understand patient information in the consent form exclusion criteria: * hemodynamic instability * left ventricular ejection fraction (lvef) \< or = 35% * heart failure class iii -iv (new york heart association (nyha) functional classification) * refractory angina * any pathology for which physical exercise is not indicated

Keywords: cardiac rehabilitation programs adherence to secondary preventive measures acute coronary syndrome more intensive cardiac rehabilitation program in less time
palliation of dyspnea with morphine in patients with interstitial lung disease

Conditions: Interstitial Lung Disease; Dyspnea; Morphine

Summary: 36 patients with interstitial lung disease will be randomized to 1 weeks treatment with morphine hydrochloride as oral linctus 5 mg, four times a day, and 5 mg as needed up to 4 times a day, or corresponding doses of placebo. vas score for dyspnea will be evaluated after 1 hour and 1 week at follow up. other questionnaires will also be evaluated (gad-7, k-build, leicester score)


Eligibility criteria:
inclusion criteria: * a diagnosis of interstitial lung disease (ipf, nsip, ra-ils, scl-ils, mctd-ils, asbestous, drug induced ild, unclassified ild) * dyspnea corresponding to medial research councils (mrc) dyspnea score ≥ 3 * written consent * age ≥ 18 years * competent * for fertile women: negative pregnancy test * for fertile and sexually active participants: use of safe anti-conceptionals exclusion criteria: * ongoing infection * decreased lung function to a degree which makes any form of respiratory depression life threatening * treatment with morphine or morphine analogues * allergy towards morphine hydrochloride

Keywords: randomised placebo controlled clinical trial
the detection of circulating tumor cells (ctcs) in patients with colorectal cancer undergoing cryosurgery combined with dc-cik treatment

Conditions: Neoplastic Cells, Circulating

Summary: circulating tumor cells (ctcs) have the potential to provide a surrogate for'real-time biopsy' of tumor biological activity. enumeration and molecular characterization of ctcs in colorectal cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy biomarkers. in view of these facts, the investigators wanted to demonstrate the value of multiparameter flow cytometry in detecting human tumor cells of colorectal cancer in normal peripheral blood after cryosurgery with or without dendritic cell(dc)-cytokine-induced killers(cik) treatment, and the investigators also compared the specificity with reverse transcriptase polymerase chain reaction (rt-pcr) method.

1 day before and 2 days after cryosurgery with or without dc-cik treatment，approximately 17-ml ethylene diamine tetraacetic acid(edta)-blood was drawn by vein puncture from patients with colorectal cancer and healthy volunteers. the blood of the healthy volunteers will be used to evaluate the sensitivity and specificity and as negative control cells. to avoid contamination with skin cells, 2 ml blood will be discarded before the study samples will be taken.briefly, the mononucleate cells will be separated from the blood over ficoll- paque for 20 min with 1800g at 4℃. the interface cells will be removed and washed, and the red blood cells(rbcs) will be removed using a lysis buffer followed by a repeated wash. the mononuclear cells will be counted and aliquot for rt-pcr and multiparameter flow cytometry on the basis of at least 2-3×106 cells for each methodology. the cell pellet will be resuspended in phosphate-buffered saline for multiparameter flow cytometry and in trizol reagent for rt-pcr. aim : identification of ctcs may lead to better diagnosis and prognosis and could help to choose an adequate therapy.

Eligibility criteria:
inclusion criteria: 1. age:18-75 2. karnofsky performance status \>60 3. diagnosis of colorectal cancer based on histology or the current accepted radiological measures. 4. classification tumor,nodes,metastasis-classification(tnm) stage: ⅱ,ⅲ,ⅳ 5. will receive cryosurgery and/or dc-cik treatment 6. life expectancy: greater than 3 months 7. patients' routine blood test, liver function and kidney function have no obvious abnormalities 8. ability to understand the study protocol and a willingness to sign a written informed consent document exclusion criteria: 1. patients with other primary tumor except colorectal cancer 2. history of coagulation disorders or anemia

Keywords: colorectal neoplasms circulating tumor cells
identification of criteria of the success of the endarterectomy in chronic pulmonary post embolic hypertension

Conditions: Chronic Thromboembolic Pulmonary Hypertension

Summary: in order to improve effectiveness of the surgical operation thanks to a reduction in the rate of failure, this study will allow us to identify predictive angiographic and ct finding of surgical failure, starting from standardized reading grids, in order to have a better selection of the operable patients.

chronic thromboembolic pulmonary hypertension(cteph) is caused by obstruction of the large pulmonary arteries by acute and recurrent pulmonary emboli, and organization of these blood clots. antoine beclere respiratory unit, in partnership with the marie lannelongue hospital thoracic and vascular surgery departments was designated recently as reference national centre for pulmonary hypertension and represents the only french structure for evaluation of cteph with 150 patients addressed each year.if the disease is proximately located, cteph can be cured surgically through a complex surgical procedure performed under hypothermia and total circulatory arrest. in spite of multidisciplinary meeting deciding the operability of each case the rate of failure is approximately of 15% (9% of operative mortality rate and 6% of technical failure). the aim of this study is to identify predictive angiographic and ct findings of success, by allowing a better selection of operable patients. it would be possible to improve the effectiveness of the surgical treatment and reduce the rate failure from 15% to 7 % or even 5 %.

Eligibility criteria:
inclusion criteria: * patients addressed to the reference centre of pulmonary hypertension for a suspected cpc-pe * achieving an assessment prior to the operation, including:1) right cardiac catheterization confirming htp with a mean pulmonary arterial pressure\> 25 mm hg at rest; 2) echography and doppler of the lower limbs in search of phlebitis sequela; 3) pulmonary scintigraphy with 6 views in ventilation and perfusion; 4) digital pulmonary angiography; 5) a 64 detector pulmonary computed tomography; 6) having read the briefing note and given their agreement. exclusion criteria: * refusal examinations . * patient for which one method is contraindicated * patient considered not operable by the staff * life expectancy of less than 3 months * geographical distance for the clinical follow-up at 3 months * renal insufficiency (creatinine clearance \<30 ml / min) * proven allergy to iodinated contrast agents * pregnant woman.

Keywords: pulmonary hypertension chronic thromboembolic pulmonary hypertension operability thromboendarteriectomy operative mortality rate technical failure pulmonary angiography computed tomography
pain and quality of life after retromuscular ventral hernia repair (recover)

Conditions: Ventral Hernia

Summary: the study aims to explore the difference in outcomes relating to pain and quality of life after open, laparoscopic, and robotic-assisted retromuscular ventral hernia repair.

this is a prospective, multicenter, observational study assessing outcomes relating to pain and quality of life for subjects undergoing open, laparoscopic, or robotic-assisted retromuscular ventral hernia repair. the study will focus on short-term post-operative outcomes through 3 months. the study will also collect recurrence data through 1 year. during the post-operative period through 3 months, pain medication intake, subject reported pain (on post-operative day 7, 14, 21, 28, and 3 months) and quality of life (on day 28, 3 months, and 1 year) and incidence of intra-operative and post-operative adverse events related to the ventral hernia repair will be collected.

Eligibility criteria:
inclusion criteria: * subject is between 18 and 89 years of age * subject is a candidate for an elective retromuscular ventral hernia repair under general anesthesia * subject has access to complete study assessments electronically and agrees to comply with all follow-up requirements * ventral hernia is \>= 4cm exclusion criteria: * subject who will have an emergent hernia repair * subject has a parastomal hernia (i.e. hernia related to ostomy formation) * subject with a history of chronic pain and/or taking daily pain medication for \>6 weeks * subject wtih a history of substance abuse (excluding marijuana) and/or current (within 30 days) narcotic use * subject with a history of mrsa infection * subject with hba1c level \> 8.5% * subject undergoing a minimally invasive (mis) repair who will require the use of exparel during the surgical procedure * subject who will undergo a concomitant hernia repair or any other concomitant procedure * subject has cirrhosis * current nicotine use (including vaping) within the past 30 days * subject is contraindicated for general anesthesia or surgery * subject has a known bleeding or clotting disorder * pregnant or suspected pregnancy * subject is mentally handicapped or has a psychological disorder or severe systemic illness that would preclude compliance with the study requirements or ability to provide informed consent * subject belonging to other vulnerable population, e.g., prisoner or ward of state * subject is currently participating in another interventional research study
cerclage for singletons with short cervix without prior preterm birth

Conditions: Preterm Birth

Summary: preterm birth remains the most common cause of perinatal morbidity and mortality. a short cervi- cal length on transvaginal ultrasonography has been shown to be one of the best predictors of preterm birth. in 2005 a meta-analysis by berghella et al. showed that cervical cerclage does not prevent preterm birth (ptb) in women with short cervical lenght without prior ptb. however maybe the meta-analysis did not reach the statistical significance due to the small sample size


Eligibility criteria:
inclusion criteria: * singleton pregnancy (limits the participants to female gender) * short cervical length (less than or equal to 25 mm) on second trimester ultrasound at 18-23 6/7 weeks gestation * 18-50 years of age exclusion criteria: * multiple gestation * prior spontaneous preterm birth 16-36 6/7 weeks * ruptured membranes * lethal fetal structural anomaly * fetal chromosomal abnormality * pessary in place (or planned placement) * vaginal bleeding * suspicion of chorioamnionitis * ballooning of membranes outside the cervix into the vagina or cl = 0 mm on transvaginal ultrasound * painful regular uterine contractions * placenta previa
the effect of hybrid tele-rehabilitation versus in person rehabilitation on pain and function in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: people with knee osteoarthritis often need regular physiotherapy sessions to reduce pain and improve movement. attendance of in-person sessions can be difficult because of travel and time. this study aims to learn if combining in-person and video sessions using zoom works for people with knee osteoarthritis. the main questions it aims to answer are : * does combining in-person and video sessions improve pain and physical function in people with knee osteoarthritis? * does combining in-person and video sessions improve adherence to the exercise program? * are people satisfied with video sessions using zoom? the researchers will compare the use of one in-person session and one video session per week to the standard care of two in-person sessions per week. participants will : * attend either (one in-person and one video session per week) or (two in-person sessions per week) for 8 weeks. * perform exercise program that suits their needs during in-person and video sessions. * record the number of attended sessions over 8 weeks. * complete questionnaires about pain, physical function at the start and the end of the study. * complete questionnaire about usability and satisfaction at the end of the study.


Eligibility criteria:
inclusion criteria: * mild to moderate knee osteoarthritis. * age 40 to 80 years old. * body mass index \< 34 kg/m2. * numeric pain rating scale \> 4 out of 10. * pain for more than 3 months. * morning stiffness lasting \< 30 minutes (standard clinical criteria of knee osteoarthritis) * pain and crepitus with active motion (e.g., walking, sit to stand, stair climbing) (standard clinical criteria of knee osteoarthritis) * access to the device with an internet connection. * ability to use electronic devices or smart phones. exclusion criteria: * severe knee osteoarthritis and limited mobility or bonded to a wheelchair. * body mass index \> 34 kg/m2 * on a waiting list for hip or knee surgery. * undergoing other forms of rehabilitation. * previous knee arthroplasty. * recent knee surgery within 6 months. * received cortisone injection within the previous 30 days. * rheumatoid arthritis, bilateral knee morning stiffness \> 30 minutes. * unstable medical conditions.
multiple-dose pharmacokinetics of ceftaroline during continuous and intermittent renal replacement therapy in patients requiring renal replacement therapy

Conditions: Infection During Renal Replacement Therapy

Summary: the study will be conducted to investigate the pharmacokinetics of ceftaroline during continuous and intermittent renal replacement therapy.


Eligibility criteria:
inclusion criteria: * age \>18 years, able to give written informed consent * suspected or proven bacterial infection requiring parenteral antibiotic therapy. * renal replacement therapy (continuous or intermittent) exclusion criteria: * known hypersensitivity to ceftaroline or other cephalosporins, or severe hypersensitivity (anaphylactic reaction) to beta-lactam antibacterial agents. * an expected survival of less than two days. * known pregnancy * coadministration of valproic acid or probenecid, which cannot be discontinued for the duration of the study * ceftaroline as monotherapy for resistent species or fungal infections. * other reasons oposing the study participation on the discretion of the investigators

Keywords: hd cvvh renal replacement therapy ceftaroline pharmacokinetics
a mobile phone self-monitoring tool to increase emotional self-awareness and reduce depression in young people

Conditions: Depression

Summary: the mobiletype program is a mental health assessment and monitoring tool that runs on mobile phones. the program assesses the general mental health of young people in real-time and transmits this data to a website to be reviewed by their general practitioner (gp) in consultation with their patient. the website consists of individualised feedback reports for each participant, and graphical displays of the monitoring data. the primary aims of the current project are to examine: (1) whether the process of self-monitoring via the mobiletype program increases young people's awareness of their mood and reduces depressive symptoms and (2) whether emotional self-awareness mediates the relationship between self-monitoring and depressive symptoms.


Eligibility criteria:
inclusion criteria: * aged 14 - 24 years of age * proficient english * patients must be deemed to have an emotional/mental health concern by their gp or be screened to have at least a mild mental health problem (a score of 16 or above) on the k10 symptom scale exclusion criteria: * severe psychiatric or medical condition that prevents the person from complying with either the requirements of informed consent or the study protocol. * young people referred to a mental health specialist by their gp will be excluded only if they obtain a specialist appointment during the mobiletype study period (2 - 4 weeks).

Keywords: cellular phones mental health early intervention prevention momentary sampling adolescent
extended-release vs immediate-release metformin in pcos women

Conditions: Polycystic Ovary Syndrome

Summary: the aim of our study is to compare the different effects of 6 months treatment with extended-release metformin and immediate-release metformin on clinical, endocrine and metabolic parameters in women affected by polycystic ovary syndrome. we also evaluate gastrointestinal disorders associated with the two different compouds.


Eligibility criteria:
inclusion criteria: * women with pcos in accordance with rotterdam criteria exclusion criteria: * pregnancy * diabetes mellitus (or impaired glucose tolerance as determined by a standard 75 gr oral glucose tolerance test) * past history of cardiovascular diseases * past history of gastro-intestinal diseases * significant liver or renal dysfunction (hypothalamic, pituitary, thiroidal or adrenal); * neoplasms.

Keywords: pcos metformin
prognostication of recovery in early disorders of consciousness study

Conditions: Disorders of Consciousness Due to Severe Brain Injury

Summary: by collecting multimodal metrics (e.g., clinical factors, neuroimaging, and eeg) in the early phase of severe brain injury (i.e., during the acute hospitalization when a patient has impaired consciousness), and measuring the patients' recovery of consciousness, function, and quality of life in the late phase (at 6 months following the brain injury), we aim to construct an algorithm that synthesizes the results of these metrics to help predict recovery.

the primary aim of this research proposal is as follows: by collecting multimodal metrics (e.g., clinical factors, neuroimaging, and eeg) in the early phase of severe brain injury (i.e., during the acute hospitalization when a patient has impaired consciousness), and measuring the patients' recovery of consciousness, function, and quality of life in the late phase (at 3, 6, and 12 months following the brain injury), we aim to construct an algorithm that synthesizes the results of these metrics to help predict recovery. there will also be secondary aims as follows: 1. to identify patient phenotypes with predictive significance, in order to revise our classification scheme for disorders of consciousness in a clinically meaningful and data driven manner. 2. to compare prognostic value between metrics. 3. to determine how the initial goals of care expressed in the acute setting (i.e., the expected quality of life associated with disability) compare to the actual quality of life in the chronic setting (i.e., the actual quality of life associated with disability). 4. to compare the prognostic value of metrics between different etiologies of brain injury.

Eligibility criteria:
inclusion criteria: * acute brain injury (including ischemic stroke, intracranial hemorrhage, anoxic brain injury, traumatic brain injury, encephalitis) * inability to follow commands, speak intelligibly, or communicate (i.e., diagnosis of coma, vegetative state, or minimally conscious state minus) due to the underlying brain injury and within 28 days of the brain injury * age 18 or greater. exclusion criteria: * subjects will be excluded if they do not speak english (given the reliance on verbal questionnaires conducted in english) or if they regain the ability to follow commands, speak intelligibly or communicate (i.e., improves to minimally conscious state plus or greater) before they undergo mri or eeg.

Keywords: disorders of consciousness advanced neuroimaging neuroprognostication
study of vitamin d supplementation on improvement of gums health

Conditions: Gingival and Periodontal Disease; Deficiency of Vitamin D3; Pregnancy

Summary: there is a gap in knowledge regarding the effects of vitamin d supplementation on periodontal status in pregnant wome. the investigators aim to evaluate the potential benefit, if any of vitamin d supplementation during pregnancy on periodontal disease and relevant outcomes including burden of infections and prematurity rates. the investigators hypothesize that 1. vitamin d supplementation during pregnancy improves the periodontal health. 2. there is an association between inflammatory biomarkers and periodontal health of pregnant females. 3. vitamin d supplementation improves the outcomes of pregnancy such as prematurity rates and birth weight

periodontal disease is one of the most common chronic infectious diseases known to humans, with a reported prevalence varying between 10%-60% in adults. periodontal health is commonly affected in pregnancy. the prevalence of pregnancy gingivitis varies widely, ranging from around 35%- 100%. although, most of the periodontal changes during pregnancy are reversible but females with preexisting periodontitis or those who have metabolic disease such as diabetes may suffer increased periodontal destruction and may exhibit significantly greater probing pocket depth and attachment level. periodontal disease, as a source of persistent infection, may induce systemic inflammatory responses that increase the risk of adverse pregnancy outcomes. however, so far the results have been mixed. as vitamin d metabolites may also alter the inflammatory response and have antimicrobial effects thus the use of vitamin d may affect periodontal status. evidence is there which suggests that an association exists between low serum levels of vitamin d and periodontal attachment loss. if the investigators take all of the above factors in consideration, the broad picture reveals that as vitamin d deficiency is prevalent in pakistan, the pregnant females here are likely to have compromised periodontal health and probably poor pregnancy outcomes.

Eligibility criteria:
inclusion criteria: * pregnant females from 12-20 weeks of gestation who agree to participate in the study. * presence of at least 20 natural teeth in mouth excluding third molars. * for controls: non pregnant, healthy females matched with pregnant with respect to age and education. exclusion criteria: * pregnant females with high vitamin d levels, * women with metabolic diseases such as diabetes (type 1 or 2). * presence of acute dental or periodontal disease * presence of systemic disease and/or medication affecting the periodontium; * receipt of systemic antibiotic treatment or dental prophylaxis in the previous 3 months and those who do not provide informed consent

Keywords: vitamin d pregnancy periodontal health biomarkers