Kornimate/medical-research-clean huggingface dataset:
patient's perception of exercise after bone tumor resection-a qualitative study

Conditions: Bone Cancer Tumor

Summary: the aim of this study is to investigate the opinions of patients who have undergone bone tumor resection surgery about post-op exercises.

semi-structured in-depth individual interviews will be conducted with patients who have undergone bone tumor surgery. in in-depth individual interviews, the same questions will be asked to all participants and the verbal answers to these questions will be recorded with voice recorders. compared to taking notes by hand; it will be preferable to record the conversation with a voice recorder because it has advantages such as recording all the interviews and allowing the interviewer to focus on the interview. thematic analysis method will be used in the evaluation of the data.

Eligibility criteria:
inclusion criteria: * individuals aged between 18 and 65, * individuals without communication problems, * individuals who have been diagnosed with a bone tumor for the first time and who have undergone resection surgery * patients who have previously received therapeutic exercises exclusion criteria: * uncontrollable arrhythmia and/or hypertension * presence of advanced sensory deficit * visual and hearing problems * not having sufficient communication skills (mini-mental test score below 24 points) * patients undergoing head and neck bone resection

Keywords: bone cancer tumor exercise patient
routine plasma level determination to compare actual vs expected plasma levels at psychiatric inpatient admission

Conditions: Depression; Affective Disorders, Psychotic

Summary: compliance with treatment is notoriously low in psychiatric patients. traditional methods of monitoring compliance, however, may underreport nonadherence to treatment. in this study, actual plasma levels at admission - which are routinely taken at the dept psychiatry of the paracelsus medical university - were compared to plasma levels that can be expected from the prescribed preadmission dosing regimen. this was done to give treating psychiatrists a quantitatively precise idea of how frequently they can expect their patients to have plasma levels that are below the level of medication as intended by the prescribing physician.

context noncompliance or incomplete compliance with psychopharmacological medication by psychiatric patients is a frequent risk and may be underreported by classical methods (e.g., pill counts or coloring additives). objective to determined the prevalence of incomplete compliance and/or faster-than average elimination of the medication by comparing actual plasma levels with those expected from the prescribed dosage under naturalistic routine conditions. design forty-five day prospective routine survey. setting university acute inpatient clinic. participants all consecutive admissions for acute inpatient treatment from june 1, 2005 to july 15, 2005 who had been treated with antidepressants and/or antipsychotics. intervention determination of plasma levels of all psychiatric medications and their comparison to the expected plasma levels, based on known preadmission dosing regimen and average pharmacokinetic data. main outcome measures the percentage of admissions with actual plasma level that were (a) more than 2-fold lower or (b) more than 2-fold higher than the expected plasma level or (c) differing only 0.5- to 2-fold from the expected plasma level.

Eligibility criteria:
inclusion criteria: * eligible for psychiatric inpatient treatment exclusion criteria: * not eligible for psychiatric inpatient treatment

Keywords: therapeutic drug monitoring (tdm) antidepressant antipsychotic treatment adherence compliance metabolism do patients take their psychiatric medication as prescribed? do psychiatric patients metabolize their medication faster than expected? what are the exact odds that the patient of a physician prescribing antidepressants or antipsychotics has plasma levels that are below those intended?
assessing a dose-response relationship of hydralazine and its effects on dna methyltransferase 1 in polycystic kidney disease patients

Conditions: Polycystic Kidney Diseases

Summary: the purpose of this study is to find a protein (ex. polycystin 1 or mucin and cadherin like protein) in the urine that is changed after treatment of hydralazine.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of adpkd * estimated glomerular filtration rate (egfr) \> 60 ml/min/1.73m\^2 exclusion criteria: * history of systemic lupus erythematous or other rheumatologic disorder * baseline anti-nuclear antibody (ana) \>1:80 for females and \>1:40 for males * blood pressure \< 120/80 without anti-hypertensive * angina pectoris or myocardial infarction in the last 6 months * liver disease * allergy to hydralazine
prevalence of gummy smile and its causes among the egyptian population.

Conditions: Gummy Smile

Summary: prevalence of gummy smile among the egyptian population

prevalence of gummy smile among egyptian population in patients attending the kasr el aini hospital

Eligibility criteria:
inclusion criteria: * patients attending el kasr el aini hospital at the department of periodontology. * patients whose above 18 years old of both genders * patients consulting the outpatient clinic * provide informed consent exclusion criteria: * less than 18 years old * patients having problems opening their mouth or undergoing inter maxillary fixation where oral examination will not be possible * patients diagnosed with psychiatric problems or intoxicated with alcohol or drugs * patients with gingival hyperplasia * patients with extracted maxillary anterior teeth
effect of reduced noise levels and cycled light on visual and neural development in preterm infants

Conditions: Preterm Infants

Summary: noise is a hazard for newborn. in 1997, the american academy of pediatrics determined that safe sound levels in the neonatal intensive care unit (nicu) should not exceed 45 db which has been rarely achieved. high intensities of noise have several negative effects on preterm newborns. also, they are exposed to either continuous bright light continuous near darkness or unstructured combination of the two during their hospitalizations. the investigators primary objective is to determine the impact of reduced noise levels and cycled light on growth parameters and visual development in preterm infants.


Eligibility criteria:
inclusion criteria: * \ 1250g birth weight exclusion criteria: * major congenital anomaly and infection prior to enrolment * infants with surgical issues

Keywords: noise sound cycled light preterm infants neonatal care growth visual development
non-motor symptoms, balance, muscle strength, and functional mobility in patients with parkinson's disease

Conditions: Parkinson Disease; Balance; Muscle Strength; Mobility; Non-motor Symptoms

Summary: the purposes of this study is to examine balance, muscle strength, and mobility in relation with non-motor symptoms (nmss) in patients with parkinsosn's disease (pd). nmss have been shown to be the key determinant of health-related quality of life (hrqol) and have a greater effect on hrqol compared to motor symptoms.despite a growing literature on nmss, there are few data on the association between nmss and motor phenotypes of pd, and they have usually focused only on specific domains of nmss, such as cognition, mood/anxiety issues, or sleep disorders. when literature is examined, there is no study which examines balance, muscle strength, and mobility in relation with nmss in patients with pd.for all these reasons, we think that balance, muscle strength, mobility, and nmss in patients with pd are worse than those of the healthy individuals and that there is a relationship between nmss and motor symptoms.


Eligibility criteria:
inclusion criteria: * being diagnosed with pd by a neurologist, being in hoehn \& yahr stage 1-3, having no musculoskeletal system problems in the previous 6 months, having a score of 24 or more in the mini-mental state examination (mmse), and being volunteer. exclusion criteria: * healthy individuals of similar age and sex, without neurological problems, and who did not experience any musculoskeletal system problems in the previous 6 months were included in the control group.
treatment of early aggressive rheumatoid arthritis (tear)

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to 1)to determine if it is better to treat all early ra patients with methotrexate in combination with hydroxychloroquine plus sulfasalazine or in combination with etanercept or reserve this treatment for patients who do not appropriately respond to methotrexate alone and 2) to determine which combination of methotrexate therapy is better

the ultimate goal of ra is to eliminate symptoms, restoring the patient to normal physical, social, emotional, and vocational function, and preserving the structure and integrity of joints. while disease modifying anti-rheumatic drugs (dmards) have long been the cornerstone of ra therapy, the limitations of dmards have become increasingly apparent and investigators continue to gain insight into the pathogenesis of this disease. recent evidence suggests that treatment earlier in the disease process with more aggressive approaches results in superior long-term outcomes compared to less intensive treatment regimens. specifically, there is growing interest in the possibility that early "aggressive" treatment with combinations of dmards as initial treatment in efforts to potentially reduce the proportion of patients that advance to severe disability.

Eligibility criteria:
inclusion criteria: * have a diagnosis of ra for less than or equal to 3 years * be 18 years of age or older at the time of diagnosis exclusion criteria: * pregnant or lactating women * history of chronic infection, such as hepatitis, pneumonia, or chronic skin infections * active tb or evidence of latent tb

Keywords: ra painful joints swollen joints
a pilot study evaluating a clinically managed weight loss program

Conditions: Obesity

Summary: this is a pilot study evaluating a clinically managed weight loss program. the program consists of a 17-week weight loss program which involves a multidisciplinary team where personalized interventions are given to participants from the team based on the participants goals.

the clinically managed weight loss program is managed by a clinical team including a program manager, registered dietitians, canadian society of exercise physiology-certified personal trainers, clinical psychology associate or cognitive behavioural therapist, and a physician. the team will collaborate together to prescribe a plan best suited for the participants' needs with the focus on lifestyle changes, such as, sleep, mental health, and behaviours. outcome measures will be collected as part of the pilot study, such as, anthropometric measurements and body composition, cardiovascular assessment, clinical chemistry, physical activity, nutrition, and behaviour and health screening questionnaires.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the trial. * male or female, aged 18 years or above. * are overweight or obese (bmi over 24.9) exclusion criteria: - female participant who is pregnant or lactating.

Keywords: pilot study program evaluation nutrition exercise psychology
additional effects of perioperative immunonutrition in patients undergoing pancreaticoduodenectomy

Conditions: Pancreatic Tumor; Bile Duct Tumor

Summary: the purpose of this study is to investigate whether perioperative immunonutrition has additional effects on cell-mediated immunity in patients undergoing pancreaticoduodenectomy.

the investigators reported that perioperative immunonutrition had no additional effects compared with preoperative immunonutrition in patients underwent colorectal surgery (braga m, gianotti l, vignali a, carlo vd. preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. surgery. 2002; 132:805-14, pmid: 12464864). object of this study is to investigate the additional effects of perioperative immunonutrition on cell-mediated immunity and incidence of infectious complication after pancreaticoduodenectomy.

Eligibility criteria:
inclusion criteria: * patients undergoing pancreaticoduodenectomy exclusion criteria: * age younger than 18 years old * ongoing infection * gastrointestinal obstruction * respiratory dysfunction * cardiac dysfunction * hepatic dysfunction * renal failure * history of recent immunosuppressive or immunological disease * preoperative evidence of widespread metastatic disease

Keywords: immunonutrition
a study assessing safety and efficacy of md-15 intraocular lens in patients with aphakic eye after cataract surgery

Conditions: Cataract

Summary: to evaluate safety and efficacy of md-15 intraocular lens implanted into the aphakic eyes


Eligibility criteria:
inclusion criteria: * patients who intend to undergo phacoemulsification cataract extraction exclusion criteria: * patients who undergo secondary implantation * patients with vision loss induced by causes other than cataract * patients who the principal investigator/subinvestigator considers ineligible for enrollment
adjunctive phototherapy treatment of infected diabetic ulcers

Conditions: Diabetic Foot; Diabetic Foot Ulcer; Diabetes; Diabetes Mellitus; Infected Wound; Infected Ulcer of Skin

Summary: the key purpose of this study is to determine and understand the safety and effectiveness of blue light phototherapy in the treatment and healing of infected diabetic wounds, as well as determining if this treatment is capable of reducing the bacterial population number within infected wounds. the investigators' lab recently discovered that a specific survival protein called catalase can be destroyed through blue light exposure. given that a majority of bacteria species contains catalase, it is hypothesized that the destruction of this protein can improve the effectiveness of antimicrobial wound dressings commonly used to treat infected diabetic wounds, therefore further reducing the amount of bacteria within the wound and increasing the rate of healing. by reducing the overall bacterial population within these diabetic infected wounds, the ability for these diabetic wounds to heal will be enhanced, allowing for greater reductions in wound size over the course of the treatment. in this study, 40 subjects will be enrolled and randomly assigning subjects to either a control group or a phototherapy receiving experimental group. while control subjects will receive standard weekly debridement treatment procedures for infected diabetic ulcers, experimental subjects will receive standard weekly debridement treatment alongside 2 sessions of phototherapy every week over the course of 12 weeks. bacterial swab samples will be taken alongside the excised debrided infect tissue for the purpose of bacterial population analysis. for each patient, the changes in total bacterial population, wound size, and subject satisfaction will be recorded and analyzed to determine the effectiveness of pulsed light phototherapy.


Eligibility criteria:
inclusion criteria: * english speaking * capacity to consent * diabetic foot ulcers * have an infected wound present on the foot greater than 1 (one) cm2 and less than 8 cm2 * ability to utilize appropriate offloading devices as recommended by a clinician exclusion criteria: * pregnant or breastfeeding/nursing * ankle-brachial pressure index below 0.45 or over 1.4 * hemoglobin a1c levels above 12.0 * stage 4 renal disease/dialysis * taking immunosuppressant medications * undergoing radiation therapy * diagnosed uncontrolled/resistant hypertension (htn) - high blood pressure that does not respond well to medical treatment, blood pressure remains above average (usually 130/80 mmhg) despite medication usage. * diagnosed uncontrolled malabsorption disorder - small intestine unable to absorb nutrients effectively, usage of nutrient supplements ineffective * active sepsis * uncontrolled coagulopathy - blood unable to properly coagulate and form clots, low platelet or clotting factor levels, unresponsive to medications * untreated bone/soft tissue infection - not yet initially treated to reduce risk of sepsis * gangrene of wound under care

Keywords: phototherapy blue light phototherapy light therapy
interferon alfa, isotretinoin, and paclitaxel in treating patients with recurrent small cell lung cancer

Conditions: Lung Cancer

Summary: rationale: drugs used in chemotherapy, such as paclitaxel, work in different ways to stop tumor cells from dividing so they stop growing or die. some tumors become resistant to chemotherapy drugs. giving interferon alfa and isotretinoin together with paclitaxel may reduce resistance to the drug and allow the tumor cells to be killed. purpose: this phase ii trial is studying how well giving interferon alfa and isotretinoin together with paclitaxel works in treating patients with recurrent small cell lung cancer.

objectives: * determine the frequency and duration of response in patients with recurrent small cell lung cancer treated with interferon alfa, isotretinoin, and paclitaxel. * determine the toxic effects of this regimen in these patients. * determine the duration of survival in patients treated with this regimen. * correlate the levels of bcl-2 in peripheral blood monocytes with response and survival in patients treated with this regimen. outline: this is a multicenter study. patients receive interferon alfa subcutaneously and oral isotretinoin on days 1 and 2 and paclitaxel iv over 1 hour on day 2 of weeks 1-6. courses repeat every 8 weeks in the absence of disease progression or unacceptable toxicity. patients are followed every 3 months for 2 years and then every 6 months for 1 year. projected accrual: a total of 37-83 patients will be accrued for this study.

Eligibility criteria:
inclusion criteria * histologically or cytologically confirmed recurrent small cell lung cancer (sclc) with clinically confirmed measurable disease * age 18 and over * ecog performance status 0-3 * absolute neutrophil count at least 1,500/mm\^3 * platelet count at least 100,000/mm\^3 * bilirubin no greater than 1.5 mg/dl * ast no greater than 2 times upper limit of normal (uln) * creatinine no greater than 1.5 mg/dl * triglycerides no greater than 1.5 times uln * patients must have had prior chemotherapy treatment for sclc, and toxicities must have resolved to less than or equal to grade 1 * women of childbearing potential and sexually active males are strongly encouraged to use an accepted and effective method of contraception. exclusion criteria * history of another neoplasm other than sclc except for non-metastatic, non-melanoma skin cancers, carcinoma in situ of the cervix, or cancer cured by surgery or small field radiotherapy at least 5 years before registration * pregnant or nursing, with a negative pregnancy test within 2 weeks prior to registration * severe depression requiring medication * use of the following drugs within 4 weeks prior to registration: carbamazepine, ethanol, tetracycline, doxycycline, minocycline, topical acne products containing retin-a, vitamin a, cisplatin, ketoconazole, phenytoin or other antiepileptic drugs * use of gm-csf or g-csf within 4 weeks prior to registration * prior paclitaxel or interferon therapy * radiation therapy within 60 days prior to registration * chemotherapy within 60 days prior to registration

Keywords: recurrent small cell lung cancer
characterization of hamstring and quadriceps neuromuscular fatigue after soccer game

Conditions: Neuromuscular Fatigue; Exercise

Summary: this is a monocentric study comparing hamstring and quadriceps neuromuscular fatigue after simulated soccer game, anaerobic and aerobic training sessions. the purpose of this study was: 1. to quantify the decrease of isometric force immediately after a simulate soccer game. 2. to characterize peripheral and central fatigue between hamstring and quadriceps muscles and described the kinetics of recovery after specific tasks of soccer training. 3. to compare the level neuromuscular fatigue induced by anaerobic and aerobic training. 4. to highlight correlation between neuromuscular fatigue and performance markers.


Eligibility criteria:
inclusion criteria: * male * age limits: minimum: 16 ; maximum: 40 years old * to be a soccer player, licensed to the french football federation * affiliation to the social health insurance scheme * signing an informed consent form exclusion criteria: * impossibility to give the subject enlightened information (subject in emergency situation, difficulties in understanding the study, ...) * subject under the protection of justice * subject under guardianship or curatorship * lower limbs musculotendinous or articular problems * smoker or having been a smoker in the last 5 years * subject wearing a pacemaker * drug treatment in progress and impossibility to stop it within 7 days before the beginning of the study.

Keywords: hamstring neuromuscular fatigue soccer performance
periacetabular osteotomy with and without arthroscopic management of central compartment pathology

Conditions: Hip Dysplasia

Summary: at present, it is not clear whether performing a hip arthroscopy at the same time as a pao improves patient outcomes after surgery compared to a pao alone. this research project will randomize patients to receive either a pao alone, or a pao and a hip arthroscopy at the same time.

hip dysplasia is a developmental abnormality of the acetabulum (hip socket) that causes abnormal stresses inside the hip joint and leads to painful arthritis at a young age. many patients develop painful symptoms in their hip before advanced arthritis occurs. the periacetabular osteotomy (pao) is a surgical procedure that reorients the acetabulum to reduce the stresses inside the hip joint. the pao is very effective at improving symptoms and quality of life. however, some patients may have residual symptoms. frequently, people with hip dysplasia will have an mri done before their surgery, which helps to identify other the abnormalities inside their hip joint (e.g., labral tears). these abnormalities inside the joint cannot easily be addressed through pao alone, however they can be addressed with hip arthroscopy. hip arthroscopy is a separate minimally invasive surgical procedure that allows the surgeon to access the inside of the hip joint with a small camera and address any abnormalities. at present, it is not clear whether performing a hip arthroscopy at the same time as a pao improves patient outcomes after surgery compared to a pao alone. this research project will randomize patients to receive either a pao alone, or a pao and a hip arthroscopy at the same time. patients will be followed for 2 years after surgery. symptomatic differences between the two patient groups will be assessed to determine added benefit of the hip arthroscopy.

Eligibility criteria:
inclusion criteria: * skeletally mature patient undergoing bernese periacetabular osteotomy for symptomatic acetabular dysplasia/hip instability * pre-operative mri at 3t and/or gadolinium mr arthrogram * age, 16-50 years old * patient capable of giving informed consent exclusion criteria: * prior hip/pelvis surgery of any kind on the surgical side * prior hip arthroplasty surgery on either side * radiographic evidence of arthritis (i.e. tönnis grade =2) * known connective tissue disorder (e.g. ehlers-danlos syndrome, etc.) * known neuromuscular disorder (e.g. cerebral palsy, spina bifida, etc.) * known skeletal dysplasia (e.g. achondroplasia, multiple epiphyseal dysplasia, etc.) * cognitive impairment that prevents accurate completion of patient-reported outcome questionnaires. * patient unable/unwilling to complete all required follow-up visits * concurrent proximal femoral osteotomy and/or surgical hip dislocation