Kornimate/medical-research-clean huggingface dataset:
long-term follow-up of antithrombotic management patterns in acute coronary syndrome patients in asia-china extension

Conditions: Acute Coronary Syndromes

Summary: this study is to describe the long-term antithrombotic management patterns in a real-life setting for patients hospitalized with an acute coronary syndrome in china.

this study is to describe the long-term (3 to 5 years after the acute coronary syndrome index event) antithrombotic management patterns in a real-life setting for patients hospitalized with an acute coronary syndrome (i.e. st-segment elevation myocardial infarction, non-st-segment elevation myocardial infarction, unstable angina) in china.

Eligibility criteria:
inclusion criteria: 1. written informed consent has been provided. 2. contact order form has been provided 3. aged 18 years or older. 4. enrolled in epicor asia study and completed the 2 year follow-up. exclusion criteria: 1. presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient (e.g. tourist, non-native speaker or does not understand the local language, psychiatric disturbances, alcohol or drug abuse). 2. already included in the epicor asia-china extension observational study. 3. presence of serious/severe co-morbidities in the opinion of the investigator which may limit short term (i.e. 6 month) life expectancy. 4. current participation in an interventional clinical trial. 5. patients receiving ticagrelor beyond 12 months and other off label use.
an ehealth intervention for obsessive compulsive disorder in youth with autism spectrum disorder

Conditions: Obsessive-Compulsive Disorder

Summary: this study is a feasibility study of internet-delivered cbt for ocd in children and adolescents (7-17 years) with comorbid autism spectrum disorder.

the main objectives of this study is to evaluate the feasibility, acceptability and preliminary efficacy of internet-delivered cognitive behavioral therapy (icbt) for obsessive compulsive disorder (ocd) in children and adolescents (7-17 years) with autism spectrum disorders (asd). the study will an open trial with-in group mean comparison design (n=18). the treatment is delivered over 16 weeks. study participants will be followed up at 3 (primary endpoint), 6 and 12 months after completed treatment. icbt is expected to decrease ocd-symptoms.

Eligibility criteria:
inclusion criteria: * a diagnosis of ocd according to dsm-5 * a diagnosis of autism according to dsm-iv or dsm-5, confirmed with the autism diagnostic interview- revised or autism diagnostic observation schedule version 1 or 2 and by medical records * a total score of ≥ 16 on the children's yale-brown obsessive-compulsive scale * age between 7 and 17 years * ability to read and write swedish * access to the internet * a parent that is able to co-participate in the treatment * participants on psychotropic medication must have been on a stable dose for the last 6 weeks prior to baseline assessment exclusion criteria: * a diagnosis of psychosis, bipolar disorder, severe eating disorder or intellectual disabilities * comorbid hoarding disorder or ocd with hoarding as a principal symptom. * suicidal ideation * subject not able to read or understand the basics of the icbt material * completed cbt for ocd within last 12 months (defined as at least 5 sessions of cbt including exposure and response prevention) * ongoing psychological treatment for ocd or any anxiety disorder * ocd treatment is not an immediate priority

Keywords: ocd asd obsessive compulsive disorder autism spectrum disorder icbt ehealth internet cbt pediatric adolescents children internet-delivered
diagnostic and prognostic value of new biomarkers in patients with heart disease

Conditions: Heart Failure; Dyspnea; Pulmonary Disease

Summary: the objective of this work is to investigate and then to sequence new biomarkers in the plasma of patients presenting with dyspnea secondary or not to heart failure, and study their diagnostic and prognostic value.

plasma samples for patients with dyspnea, edema, with or without heart failure; ambulatory or admitted for cardiac decompensation (even with cardiac shock and lvad) ; or entering a cardiac rehabilitation program, will be prospectively collected. the objective of this work is to investigate and then to sequence new proteins in the plasma of these patients for diagnostic and prognostic purpose.

Eligibility criteria:
inclusion criteria: * patients presenting with shortness of breath secondary or not to heart failure, even with cardiac shock and lvad. * patients with valvular disease * chronic stable heart failure. * post- partum cardiomyopathy exclusion criteria: * terminal cancer * progressive neurological disease * pregnancy * opposition of the patient

Keywords: heart failure dyspnea heart disease pulmonary disease natriuretic peptide rehabilitation
ranibizumab in preventing failure of ahmed valve glaucoma surgery

Conditions: Glaucoma

Summary: to determine whether ranibizumab therapy before and after tube insertion for glaucoma surgeries can maintain the patency of the tube and prevent scar formation, and increase the chances for a successful procedure compared to observation.

this is a randomized, open-label, phase i/ii study of intravitreally administered ranibizumab for the treatment of tube patency in glaucoma patients. thirty (30) patients with severe glaucoma requiring tubes will be randomized (2:1) to either ranibizumab or observation. consented, enrolled subjects assigned to the treatment group will receive open-label intravitreal injection of 0.5 mg ranibizumab 1 week prior to tube insertion and then monthly x 2 more injections sham intravitreal injections for the observation group will not be performed. study periods: study start date: may 1st, 2007 (estimated) enrollment period: 6-8 months (estimated) follow-up period: 6 months study end date: december 1st, 2010 (estimated)

Eligibility criteria:
inclusion criteria: 1. ability to provide written informed consent and comply with study assessment for the full duration of the study. 2. age ≥ 21 3. diagnosis of glaucoma and determined to be candidate for therapy with tube insertion. exclusion criteria: 1. pregnant or lactating females 2. persons on oral contraceptives and women of child-bearing age 3. prior enrollment in the study 4. any conditions the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated 5. participation in another simultaneous medical investigation or trial 6. history of active inflammatory, infectious, or idiopathic keratitis precluding view of anterior segment structures 7. previous injections of ranibizumab in either eye. 8. persons on plavix (clopidogrel bisulfate) and coumadin 9. persons with uncontrolled high blood pressure 10. persons with renal or liver disease

Keywords: glaucoma,ahmed valve
moderate intensity functional training as adjuvant treatment in patients with peripheral arterial disease

Conditions: Peripheral Arterial Disease; Intermittent Claudication

Summary: traditional aerobic training and muscle resistance ('strength') training have been shown to be effective for improving functional and health-related quality of life (hrqol) outcomes in peripheral arterial disease (pad). however, the transfer of the current resistance exercise modes proposed to other activities of daily living (adls) is questionable. moderate intensity functional training (mift) has emerged with the aim of achieving cardiovascular and neuromuscular adaptations simultaneously with functional exercises typical of adls. the effect of mift in patients with pad is not yet known. our purpose is to verify the influence of the combination of intermittent treadmill walking exercise with mift compared with intermittent treadmill walking exercise on functional capacity, hrqol, biochemical and hemodynamic parameters in patients with pad.


Eligibility criteria:
inclusion criteria: * subjects with pad in grade iia (leriche-fontaine classification). exclusion criteria: * subjects with dementia. * institutionalized subjects in social health centers. * subjects with recent major surgery in the last year or lower limb amputations. * subjects with revascularization surgery of the lower extremities.

Keywords: peripheral arterial disease supervised exercise therapy functional training intermittent claudication
non-operative treatment in first-time patellar dislocation

Conditions: Patellar Dislocation

Summary: study to evaluate the conservative treatment of patients after their first episode of primary lateral patellar dislocation. randomized controlled trial with 2 groups: standard treatment (2-weeks with brace) followed by physical therapy, compared with knee taping and physical therapy. 1-year follow-up. measurements include physical exam, radiographs and mri. outcomes: recurrence, lateral patellar tilt, functional scores, apprehension, pain. hypothesis: less recurrence in the knee taping group, as well as better functional scores.

patients between 10-40 years old with first patellar dislocation are invited to participate in this conservative treatment study. patients are excluded if they have bilateral acute patellar dislocation, previous surgeries in the affected knee, osteochondral fracture, open patellar dislocation. this is a randomized controlled trial with four groups of treatment: 1. standard treatment (2-weeks with a knee brace) and physical therapy 2. knee taping and physical therapy (1-week with knee brace) sample size: 50 patients / knees outcomes of interest: recurrence in patellar dislocation, functional scores (banff, norwich), return to sport, patellar tilt

Eligibility criteria:
inclusion criteria: - patients with first episode of acute lateral patellar dislocation during the last 7 days. exclusion criteria: \* patients with acute bilateral patellar dislocation. * patients with open patellar dislocation. * patients with previous knee surgery in the same knee.

Keywords: patellar dislocation brace knee taping
dairy choline bioavailability

Conditions: Post-menopausal Women; Post-menopausal Status

Summary: the goal of this clinical trial is to find out if dairy is a good source of choline compared to eggs. the main questions it aims to answer are: * how the body uses choline; and, * what effect wppc has on choline metabolism. researchers will compare whey protein phospholipid concentrate (wppc) to whole egg powder to see if wppc is as effective as eggs. participants will drink a chocolate-flavored drink mixed with either wppc or whole egg powder.

this study is intended to evaluate the bioavailability and metabolism of choline in wppc compared to the most commonly -used food for bioavailable choline, whole egg. the intent of the evaluation is to improve the knowledge of how wppc contributes to the nutritional needs and health of postmenopausal women.

Eligibility criteria:
inclusion criteria: * ages between 51 and 70 * is currently post-menopausal (post-menopausal is a term used to describe the time in a woman's life after she has gone through menopause. this usually happens between the ages of 45 and 55. menopause is when a woman's menstrual periods stop permanently (at least 12 months)) * not allergic to the intervention foods and allergens that are related to the production of intervention foods (e.g. dairy products, egg, fish, peanut, shellfish, soy, tree nuts, wheat, crustaceans, gluten, mollusks, mustard, sesame seeds.) * had stable body weight (± 5%) for the past 6 months * free from cancer * did not have weight loss surgery, colon surgery * do not have chronic kidney diseases * do not have malabsorption towards fat and dairy products * willing to complete health surveys * willing to complete two 4-day food records * willing to consume the chocolate-flavored intervention beverages * willing to provide blood, urine, fecal samples at baseline and after 10 days of intervention exclusion criteria: * on weight loss/weight gain diets * diagnosed with fat malabsorption * undergoing weight loss surgery * diagnosed with chronic kidney diseases * allergic to the intervention foods and allergens that are related to the production of intervention foods (e.g. dairy products, egg, fish, peanut, shellfish, soy, tree nuts, wheat, crustaceans, gluten, mollusks, mustard, sesame seeds.) * regularly using antibiotics or probiotics or prebiotics * regularly using orlistat or cetilistat * regularly using laxatives * undergoing hormone replacement therapy, or receiving hormones in any forms * unable to avoid strenuous exercise during the study (\>4 h intense exercise per day)
virtual reality's impact on upper limb function in post-stroke patients

Conditions: Stroke

Summary: stroke rank second among the top causes of death, affecting millions of people in the worldwide. approximately 70-80% survivors of stroke could experience various levels of upper limb motor impairments, which seriously affects the activities of daily life and cause serious physical and mental burden to patients and their families. as bottleneck effect in traditional rehabilitation techniques become apparent, a number of emerging technologies are being used in rehabilitation treatment in an attempt to break down this barrier.studies have shown that virtual reality (vr) training can effectively promote the remodeling of the central nervous system and has become an important research direction for motor function rehabilitation.however, most current studies still focus on evaluating the overall intervention effect of vr, with little examination of its intrinsic properties and a lack of exploration of the sense of ownership (soo) and agency (soa). hence, this study conducted different vr interventions on stroke patients to evaluate the effects of the intrinsic properties of vr and the body illusion it produces on the rehabilitation of their upper limb motor function. this study is a single-blind randomized controlled trial. a total of 120 participants will be enrolled and divided into a control group, an interactive vr group, and an immersive and interactive vr group. all groups will be tested on the virtual hand illusion before the intervention. the intervention will last for a fortnight, four times a week for one hour each time. assessment will be conducted before the intervention, at the end of the intervention, and at week 6 for follow-up. the primary outcome measure is the "fugl-meyer assessment of the upper extremity (fma-ue)". the secondary outcome measures are "soo questionnaire", "proprioceptive drift scale", "action research arm test (arat)", "nih stroke scale (nihss)", "mini mental state examination (mmse)", "electromyography (emg)", "electroencephalography (eeg)" and "functional magnetic resonance imaging (fmri)".


Eligibility criteria:
inclusion criteria: * first episode of stroke, hemorrhagic or ischemic, confirmed by computed tomography or magnetic resonance imaging of the brain; * age 40-80 years, either male or female; * 3-12 months since stroke occurrence; * mild-to-moderate or moderate-to-severe upper extremity impairment, with a fma-ue score between 16 and 53; * basic ability to communicate and comprehend the research instructions, with a score of 21 and above on the mmse scale; * agreement to participate in the study, with an informed consent form duly signed by the patient or a family member. exclusion criteria: * the presence of ferromagnetic metals implanted in the body; * visual or hearing deficits; * unstable medical conditions; * history of receiving similar vr training in the past; * a history of myasthenia gravis, multiple sclerosis, muscular dystrophy, or other diseases that may cause upper limb movement disorders.

Keywords: stroke rehabilitation virtual reality (vr) body representation upper limb dysfunction
comfort of patients under non invasive ventilation according to the mask

Conditions: COPD Exacerbation; Hypercapnia; Hypoventilation Obesity Syndrome; Acute Respiratory Failure

Summary: a sub-nasal mask with a skirt that fits the nostrils and with a dedicated port for the nasogastric tube has recently been introduced. this interface has never been compared to nasal-oral masks. we hypothesise that such a sub-nasal mask increases comfort compared to a conventional naso-oral mask. the primary objective is to compare the comfort of the sub-nasal mask with that of a standard naso-oral mask.

non-invasive ventilation (niv) is a first-line treatment for many conditions encountered in the icu. this technique requires training of heath professionals, appropriate equipment, optimisation of ventilator settings and good cooperation from the patient. indeed, niv failures lead ton invasive mechanical ventilation, thus increasing morbidity and mortality. these failures are favoured by the patient's poor tolerance to niv. the success of the treatment depends greatly on the patient's compliance and comfort. the choice of the mask is therefore essential. there are different types of interface, such as the full-face helmet, the face mask, the nasal-oral mask or the nasal mask. the nasal-oral mask rmains the most commonly used interface. recommendations emphasise the importance of choosing a mask that is the right size and best tolerated by the patient. despite benefits of niv, there are a number of potential complications: skin lesions at pressure points, particulaly at the nasal bridge, gastric distension, barotrauma, haemodynamic effects of positive presure ventilation, claustrophobia, anxiety, difficulty in speaking and eating, dry eyes, patient-ventilator asynchrony. some of these complications depend on the type of mask used. a sub-nasal mask with a skirt that fits the nostrils and a dedicated port for the nasogastric tube has recently been introduced. to our knowledge, this interface has never been compared to commercially avaible nasal-oral masks.

Eligibility criteria:
inclusion criteria: indication of niv, carried out by the physicians in charge of the patient, among the following: * copd exacerbation * hydrostatic acute pulmonary edema * acute chest syndrome with hypercapnia in sickle cell patients * post-extubation, planned in a patient at risk or recovering from extubation failure * hypoventilation-obesity syndrome exclusion criteria: formal contraindication to niv among: * indication for orotracheal intubation at the outset * non-cooperative, agitated, opponent of the technique * coma * respiratory exhaustion * shock, severe ventricular arrhythmias, immediate aftermath of cardiac arrest * undrained pneumothorax, blowing chest wound * upper airway obstruction (except sleep apnea, laryngotracheomalacia) * uncontrollable vomiting * upper gastrointestinal bleeding * measure of protection of justice * facial deformity * dying or palliative care patient * pregnancy

Keywords: non-invasive ventilation acute respiratory failure comfort
occupational stress and bipolar disorder

Conditions: Bipolar Disorder

Summary: bipolar disorder is a mental disorder characterized by alternance of depressive and manic phases, separated by intercritical phases (euthymia). the majority of patients report occupation and professional difficulties. sixty percent of bipolar patients are inactive . indeed, according to the world health organisation, bipolar disorder is the second cause of days not worked. several factors are related to the lower professional functioning observed in bipolar patients: early age of onset, delay of diagnosis and treatment, recurrence of thymic episodes, residual symptoms and cognitive disorders during euthymia, side effects of mood stabilizers. to our knowledge, no study has ever focused on well-being at work in french patients. however, suffering from a psychiatric disorder and the lack of support from colleagues and the hierarchy are risk factors for burnout, a growing health issue. patients with mental illness are often victims of stigmatization, which may involve the professional field. in addition, thymic recurrences may alter professional functioning of active patients: multiplication of work disruptions, conflicts with peers. conversely work can be stressful, promoting thyic relapses. it is therefore essential to better understand the occupational stresses of active patients suffering from bipolar disorder in order to promote functional remission beyond clinical remission. the aim of this study is to assess the level of stress and well-being at work in active french bipolar patients.

socio-demographic, psychiatric and occupational data of 200 bipolar patients will be collected over a period of 6 months.

Eligibility criteria:
inclusion criteria: * out patients and inpatients in the department of emergency psychiatry and post acute care, chu montpellier, france * to have completed the self-administered questionnaire on professional activity. exclusion criteria: * deprived of liberty subject (by judicial or administrative decision) * protected by law (guardianship)

Keywords: bipolar disorder occupational stress
a non-interventional pilot study to explore the role of gut flora in chronic urinary tract infections (uti)

Conditions: Chronic UTI; Chronic Urinary Tract Infection

Summary: correlation of microbiome to chronic urinary tract infections (uti) via relative abundance found in microbiome sequencing

relative abundance of bacterial classes within taxonomic phyla and, more broadly, within their domain will be analyzed by sequencing the gut microbiome. these data will then be categorized among specific chronic uti types.

Eligibility criteria:
inclusion criteria: 1. signed informed consent by patient 2. male or female patients age 18 and older. 3. diagnosis of chronic utis by a physician based upon urinalysis and/or urine culture. exclusion criteria: 1. refusal by patient to sign informed consent form 2. treatment with antibiotics within 2 weeks prior to screening 3. treatment with probiotics within 6 weeks prior to screening 4. history of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy. 5. postoperative stoma, ostomy, or ileoanal pouch 6. participation in any experimental drug protocol within the past 12 weeks 7. treatment with total parenteral nutrition 8. any clinically significant evidence of disease that could interfere with the subject's ability to enter the trial 9. inability of patient to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study.