Kornimate/medical-research-clean huggingface dataset:
activities of daily living participation characteristics among school-aged children with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: this study aimed to investigate the performance of activities of daily living (adl) among 53 children ages 6-10 years: 17 with high-severity asd (hs-asd), 16 with low-severity asd (ls-asd), and 20 controls with typical development. methods: the assessment combined a parent-reported questionnaire (the participation in childhood occupation; pico) alongside the pediatric evaluation of disability inventory (pedi self-care) and performance-based task, the washing hands structured observation (washho).

study objectives were to: (a) examine participation characteristics in self-care and daily activities of school-age children with hs-asd and ls-asd compared to children with typical development, based on the parent-reported participation in childhood occupation questionnaire (pico-q) for asd and pedi (b) establish the validity and reliability of the washho assessment. the research hypotheses were (a) significant differences will be found among children with hs-asd, children with ls-asd, and children with typical development in results of the pico-q and the pedi self-care subtest of independence. (b1) the internal consistency of the washho assessment will be at a cronbach alpha level equal to or greater than 70. (b2) significant differences will be found among children with hs-asd, ls-asd, and typical development in the washho assessment performance criteria, thus establishing the washho's discriminate validity. (b3) significant correlations will be found among the four pico-q adl items, which involve performing a sequence of actions (bathing, hygiene, clothing, and washing hands) and the washho assessment performance scores, establishing its convergent validity. (b4) significant correlations will be found among the washho performance and degree of independence scores and the pedi independence subtest in self-care, establishing the washho's concurrent validity.

Eligibility criteria:
inclusion criteria: hebrew speakers * study groups- asd diagnosis provided by pediatricians or clinical psychologists according to dsm-5 criteria (apa, 2013). exclusion criteria: * without asd formal diagnosis

Keywords: asd self care adl daily function executive functions
the pet-ct predicting response to immunochemotherapy in esophageal cancer

Conditions: Esophageal Cancer

Summary: treatment with immune checkpoint inhibitors such as programmed death receptor 1 (pd-1 inhibitors) for advanced and metastatic esophageal squamous cell carcinoma (escc) significantly improves patients' overall survival compared to chemotherapy alone. despite this milestone breakthrough, immunochemotherapy also has known limitations. indeed, only 45-72% of patients achieved objective responses. it is urgent to find out easily-determined and convenient biomarkers to identify patients who will benefit from such treatment modality. due to the luminal structure of the esophagus, the exact diameter of esophageal tumor cannot be precisely measured per recist 1.1. moreover, the definition of the metastatic lymph node in which the short-axis lengths should be longer than 1.5 cm hinders the risk of missing the smaller metastatic lymph node foci. thus, it is difficult to implement morphology-based criteria for evaluating the neoadjuvant immunochemotherapy response. the current study aimed to investigate the role of ipercist in predicting tumor response and the short-term overall survival of patients with locally advanced escc after neoadjuvant immunochemotherapy.


Eligibility criteria:
inclusion criteria: * pathologically confirmed locally advanced escc (ct3-4anynm0) that was potentially resectable after neoadjuvant immunochemotherapy. * treatment-naïve and had the adequate cardiopulmonary function exclusion criteria: * previous autoimmune disease * unable to complete planned treatment courses and no complete follow-up pet-ct scan
effects of whole sprouts on airway allergic inflammation

Conditions: Allergic Rhinitis; Asthma; Allergy

Summary: the primary objective of this study is to determine if broccoli sprouts (bs) improves airway inflammatory, oxidative stress (os), and symptoms among asthmatic adults with aeroallergen sensitization. the study is a double-blind, placebo-controlled, randomized trial to compare bs to placebo in 40 adults with asthma. 40 adults (age 18-50) who meet these eligibility criteria will be randomized to receive either: (a) bs or (b) placebo (alfalfa sprouts). subjects will eat a sprouts sandwich daily for three days, and then undergo repeat measurement of outcomes.


Eligibility criteria:
inclusion criteria: * doctor diagnosis of asthma * aeroallergen sensitization * non-smoker * negative pregnancy test * not breastfeeding * normal tsh * for women, abstinent or using reliable birth control * age 18-50 years * no other major pulmonary disease such as cystic fibrosis or copd * willingness to participate in study and sign consent form exclusion criteria: * severe or unstable asthma defined as requiring hospitalization in the previous 6 months or intubation in the previous 2 years, or on high-dose inhaled corticosteroids or chronic oral corticosteroids * uncontrolled asthma defined as short-acting beta agonist use 3 or more days a week in the previous 4 weeks * other significant medical issues such as heart disease or poorly controlled hypertension, type 1 diabetes, poorly controlled type 2 diabetes, or hypothyroidism * pregnancy or nursing/breastfeeding mothers * on beta-blocker therapy * on reserpine, clonidine, imipramine, or related tricyclic drugs * taking anti-oxidant supplements * planned dietary changes during the study period * unable to stop antihistamines prior to skin testing * food allergy to broccoli sprouts or alfalfa sprouts * omalizumab use within the last 12 months * nasal polyps

Keywords: asthma allergic rhinitis dietary interventions mouse allergy
west nile virus seroprevalence under bird ringers

Conditions: West Nile Virus

Summary: in august 2020, west nile virus (wnv) was isolated from a live common whitethroat for the first time in the netherlands. follow-up sampling showed that the virus could also be detected in mosquitos from the same location during at least a whole month of sampling. on 15 october 2020, one case of west nile virus infection has been reported in a man who was likely infected in the utrecht region. this is the first time that a locally acquired human case of wnv infection has been reported in the netherlands. six additional cases have been identified, one of which from the region arnhem. west nile virus infection is a mosquito-borne zoonosis. the disease, which has spread across the northern hemisphere in the past three decades, is now found on an annual basis in many european countries where the centre of gravity lies in southern-european countries. recently, wnv was reported for the first time in germany. the virus is transmitted among birds through the bite of infected mosquitoes and incidentally infects humans and other mammals, such as horses. around 80% of human wnv infections are asymptomatic. the most common clinical presentation is west nile fever but, older people and immunocompromised persons are at higher risk of developing neuro-invasive disorders (west nile neuroinvasive disease). currently, there are no prophylaxis or specific treatment against the disease in humans. in addition, usutu virus (usuv) was detected in the netherlands in 2016. usuv is another flavivirus, related to wnv, and also capable of infecting humans. disease associated with usuv infection in humans appears to be milder and only limited number of cases have been identified. during their bird catching activities, bird ringers are intensively exposed to mosquito bites at the natural habitat of the birds and at the same time of the day when mosquitoes are particularly active. the aim of this study is therefore to determine the prevalence of wnv and usuv serum antibodies in bird ringers in the netherlands.


Eligibility criteria:
inclusion criteria: * carrying-out bird ringing activities during spring, summer or early autumn 2020 in the netherlands exclusion criteria: * not willing to participate in this study * using medication interfering with antibodies production * under 18 years of age
randomized controlled trial on the use of flammacerium in necrotic arterial wounds of the lower limb versus standard treatment

Conditions: Ischemic Wound of the Lower Limb; Necrotic Arterial Wounds

Summary: ischemia of an area may lead to a necrotic wound. in lower limb, it especially happens in diabetic or artheriopatic patients. it can lead to an amputation need. revascularization procedure cannot be provide in all cases. flammacerium, by a crust training and its anti-inflammatory effect, could stabilize necrosis extension, avoid bacterial contamination and then improve some incapacitating symptoms like odor or pain. this product may allow to delay amputation ruling for patients on who this procedure is unsafe. during 6 months, the investigators evaluate flammacerium against standard dressing procedure in necrotic wound of the lower limb in patients where no revascularization can be provide. the investigators observed its effect on amputation need, symptoms as pain, infection, wound aspect evolution, wound size decrease.


Eligibility criteria:
inclusion criteria: * ischemic wound of the lower limb * minimum 50% necrosis * arteriopathy with abi\ 1.3 with radiographic examinations * no revascularisation procedure possible for any reasons * no urgent amputation need * amputation considered in a short term * non life-threatened patients exclusion criteria: * sulphonamide hypersensibility * propyleneglycols hypersensibility * enzyme glucose deshydrogenase deficiencies * others studies participation * tutorship or curatoship

Keywords: flammacerium ischemic wound lower limb arteriopathy amputation dressing
effects of different exercise training dose on exercise performance and noninvasively estimated muscle oxygen extraction in diabetic postmenopausal women

Conditions: Postmenopausal Diabetes

Summary: the purpose of this study is specifically to investigate (1) the exercising muscle oxygenation response in diabetic postmenopausal women; (2) the dose-response of different physical activity interventions on skeletal muscle oxygenation response; (3) the related mechanisms of training effects.


Eligibility criteria:
inclusion criteria: * sedentary postmenopausal women * ages 45 to 70 years old exclusion criteria: * known cardio-respiratory disease * diabetic complication * excessive weight change during last year * cancer and mental disorders

Keywords: postmenopausal women diabetes skin microcirculation exercise capacity skeletal muscle oxygenation dose-response relationship postmenopausal diabetic women
aneuploidy rate and stimulation protocol: recombinant follicle stimulating hormone (fsh) versus human fsh

Conditions: Aneuploidy Rate

Summary: several stimulation protocols have been used in in vitro fertilization (ivf) in a cycle of egg donation; recombinant fsh and human fsh are included. the effect of each kind of hormone on aneuploidy rate it is unknown. if there was an increase on aneuploidy rate of one of these stimulation protocols, there will be a negative effect on the successful rates in the egg donation cycles. the aim of this study is to observe if there is a different in aneuploidy rate and morphological oocyte parameters between different stimulation protocols.


Eligibility criteria:
inclusion criteria: * egg donation cycles with more than 8mii in oocyte retrieval day exclusion criteria: * male factor * uterine malformations * genetic alterations
the comparison about the response of ursodeoxycholic acid in primary biliary cholangitis only and primary biliary cholangitis with high immune globulin g or aminotransferase at west china hospital

Conditions: Primary Biliary Cholangitis

Summary: this study evaluates the different response of ursodeoxycholic acid in primary biliary cholangitis only and primary biliary cholangitis with high immune globulin g or aminotransferase at west china hospital from 2008-2017.


Eligibility criteria:
inclusion criteria: patients diagnosed with primary biliary cholangitis treated with ursodeoxycholic acid in west china hospital for at least 1 year exclusion criteria: autoimmune hepatitis primary sclerosing cholangitis

Keywords: ursodeoxycholic acid response
clinical evaluation of the use of an mhealth intervention on quality of care

Conditions: Malaria; Diarrhea; Acute Respiratory Infection

Summary: under the world health organization's (who) integrated community case management (iccm) rapid access expansion program (race), world vision niger and canada supported the niger ministry of public health to implement iccm in four health districts in niger in 2013. community health workers (chws), known as relais communautaire (rcom), were deployed in their communities to diagnose and treat children under five years of age presenting with diarrhea, malaria and pneumonia and refer children with severe illness to the higher-level facilities. two of the districts piloted rcom using smartphones equipped with an application to support quality case management and provide good timely clinical data. a two-arm cluster randomized trial assessed the impact of use of the mhealth application mainly on quality of care (qoc), but also on motivation, retention and supervision


Eligibility criteria:
inclusion criteria: * children presenting symptoms of illness exclusion criteria: -
randomized phase iii study of folfiri+avastin versus xeliri+avastin as 1st line treatment of crc

Conditions: Colorectal Cancer

Summary: this phase iii study will compare two combinations of irinotecan, folfiri versus xeliri, with the addition of avastin as 1st line treatment of colorectal cancer.

there is no data of comparison for folfiri and xeliri regimens. the reported data demonstrated that the addition of avastin in the combination of irinotecan/bolus 5-fu/lv has significant improvement of overall survival. further analysis of these results showed that patients receiving irinotecan in combination with avastin, as 1st line treatment and oxaliplatin with avastin, as second line treatment, have median overall survival 25, 1 months, which is the longest survival that has been reported.

Eligibility criteria:
inclusion criteria: * histologically confirmed locally advanced or metastatic colorectal cancer * measurable or evaluable disease * ecog performance status ≤ 2 * age 18 - 72 years * adequate liver (bilirubin ≤ 1.5 unl, sgot/sgpt ≤ 4 unl, alp ≤ 2.5 unl), renal (creatinine ≤ 1.5 unl) and bone marrow (anc ≥ 1,500/mm3, plt ≥ 100,000/mm3) function * patients with history of hemoptysis or with increased risk of thromboembolic events should be observed carefully due to administration of avastin * patients must be able to understand the nature of this study * written informed consent exclusion criteria: * previous 1st line chemotherapy * adjuvant chemotherapy with irinotecan regimen with relapse \< 6 months after the completion * active infection * history of serious cardiac disease (unstable angina, congestive heart failure, myocardial infarction within the previous 6 months, ventricular arrhythmias) * previous radiotherapy within the last 4 weeks or \> 25% of bone marrow * patients with unstable cns metastases * patients with chronic diarrhea (at least for 3 months) or partial bowel obstruction * second primary malignancy, except for non-melanoma skin cancer and in situ cervical cancer * psychiatric illness or social situation that would preclude study compliance * pregnant or lactating women * patients \> 65 years with history of arterial thromboembolic, myocardial infarction, unstable angina and pulmonary embolism

Keywords: metastatic colorectal cancer irinotecan capecitabine bevacizumab
low level laser therapy for hyposalivation

Conditions: Hyposalivation

Summary: the aim of this study was to compare the effects of different wave lengths of lllt on salivation in participants suffering from hyposalivation. this study included 30 participants whose major salivary glands were treated with low intensity diode laser btl2000 (medical technologies, s.r.o., czech republic) during 10 consecutive days. patients were randomly assigned in two groups, each of 15 patients, and treated with lllt of 830 nm and lllt of 685 nm, respectively. the whole unstimulated and stimulated saliva was measured each day during 10 days, before and after laser treatment and 10th day after treatment was ended.

low level laser treatment has proved to be effective for a wide range of oral pathologies including oral dryness, but the literature still lacks reports of clinical trials and protocols. the aim of this study was to evaluate the effects of two different laser wave lengths on salivation of patients suffering from hyposalivation. this with purpose to possibly find the optimum laser wavelength for the treatment, and to determine the better protocol for the patients suffering from hyposalivation. this study included 30 patients whose major salivary glands were treated with low intensity diode laser btl2000 (medical technologies, s.r.o., czech republic) during 10 consecutive days. patients were randomly assigned in two groups, each of 15 patients, and treated with lllt of 830 nm and lllt of 685 nm, respectively. the whole unstimulated and stimulated saliva was measured in graduated tubes each day during 10 days, before and after laser treatment and 10th day after treatment was ended.

Eligibility criteria:
inclusion criteria: * patients suffering from hyposalivation, with medical histories free of radiotherapy and sjögren's syndrome exclusion criteria: * medical histories of radiotherapy and sjögren's syndrome

Keywords: low level laser therapy hyposalivation
p53 suppressor activation in recurrent high grade serous ovarian cancer, a phase ib/ii study of systemic carboplatin combination chemotherapy with or without apr-246

Conditions: Platinum Sensitive Recurrent High-grade Serous Ovarian Cancer With Mutated p53

Summary: the purpose of this study is to make a preliminary assessment of the efficacy of a combined apr-246 and carboplatin/pld chemotherapy regimen, compared with carboplatin/pld chemotherapy regimen alone, in patients with platinum sensitive recurrent high grade serous ovarian cancer (hgsoc) with mutated p53. in addition, the study aims to assess the safety profile of the combined apr-246 and carboplatin/pld chemotherapy regimen compared with carboplatin/pld chemotherapy regimen alone, to evaluate potential biomarkers, and to assess the biological activity in tumor and surrogate tissues. the trial will enroll up to a maximum of 400 patients.


Eligibility criteria:
inclusion criteria: * confirmed high grade serous ovarian cancer, and positive nuclear immunohistochemical (ihc) staining for p53 * disease progression between 6-24 months after a first or second platinum based regimen * at least a single measurable lesion. phase ii patients only * adequate organ function prior to registration * toxicities from previous cancer therapies must have recovered to grade 1 (defined by common terminology criteria for adverse events \[ctcae\] 4.0) chronic stable grade 2 peripheral neuropathy secondary to neurotoxicity from prior therapies may be considered on a case by case basis * ecog performance status of 0 to 1 exclusion criteria: * prior exposure to cumulative doses of doxorubicin \>400 mg/m2 or epirubicin \>720 mg/m2 * history of allergic reactions to carboplatin, platinum containing compounds or mannitol and/or hypersensitivity to pld or to any of the excipients * unable to undergo imaging by either ct scan or mri * evidence of any other medical conditions (such as psychiatric illness, infectious diseases, neurological conditions, physical examination or laboratory findings) that may interfere with the planned treatment, affect patient compliance or place the patient at high risk from treatment related complications * concurrent malignancy requiring therapy (excluding non-invasive carcinoma or carcinoma in situ) * is taking concurrent (or within 4 week prior to registration) chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy that is considered to be investigational (i.e., used for non-approved indications(s) and in the context of a research investigation). supportive care measures are allowed

Keywords: ovarian cancer ovarian carcinoma high grade serous ovarian cancer recurrent cancer resistant cancer
non-invasive monitoring of respiratory function in spontaneously breathing patients with covid-19 infection

Conditions: Respiratory Failure; Ventilatory Failure; COVID-19; Pneumonia; ARDS, Human

Summary: this study uses the airgo band to monitor changes in tidal ventilation in spontaneously breathing patients with covid-19 associated respiratory failure. it aims to recognize patterns of ventilation associated with worsening respiratory failure in this patient population. if successful, this study will lead to the development of new robust methods for real-time, continuous monitoring of respiratory function in patients with respiratory failure. in turn, such monitoring methods may enable improvements in the medical management of respiratory failure and timing of interventions.


Eligibility criteria:
inclusion criteria: * admitted to the hospital * ≥ 18 years of age * clinically suspected or confirmed covid-19 infection * spontaneously breathing * for patients not on supplemental oxygen at their location of residence prior to hospital admission, need for supplemental o2 to maintain spo2 \>=92% * for patients on supplemental o2 at their location of residence prior to hospital admission, an increase in requirement of supplemental oxygen from baseline exclusion criteria: * intubated patients * pregnant women * moribund patients * patients who are on comfort measures (cmo)
mri-based neuroimaging predictors of clinical improvements following therapy in children with cerebral palsy

Conditions: Brain Injury, Chronic; Cerebral Palsy

Summary: the aim of this study is to explore the relationship between brain mri-metrics and hand function observed in children with cerebral palsy (cp),compared between baseline and the third month, and thus determine the early mri-based neuroimaging predictor of clinical improvement following therapy in children with cp.

cerebral palsy (cp) is the commonest cause of neurological disability in children. the upper limbs are often affected, with significant hand involvement from an early age.there are various methods of treatment for cp children with hand function disability. however, there is a lack of effective methods to predict the prognosis. this prospective cohort study will include children with occupational therapy (ot) or ot plus acupuncture and massage methods. children with cp will be evaluated in terms of upper limb motor function using the manual ability classification system (macs), fine motor function measure (fmfm). the brain injuries of children will be evaluated by mri. the aim of this study is to explore the relationship between brain mri-metrics and hand function, compared between baseline and the third month, and thus determine the early mri-based neuroimaging predictors of clinical improvements following therapy in children with cp.

Eligibility criteria:
inclusion criteria: * age: 3-18 years * spastic cerebral palsy * the complete clinical and mri data exclusion criteria: * previous acupuncture and massage methods * botulinum toxin upper limb injections * braces artifact, excessive motion, afraid to enter the mri * parents were not interested in the mri sessions