Kornimate/medical-research-clean huggingface dataset:
outcomes of endoscopic operation in covid-19 infection: cohort study.

Conditions: COVID-19; Surgery-Complications

Summary: the goal of this observational study is to determine 30-day mortality and post endoscopic surgery complications in patients with covid-19 infection who undergo endoscopic surgery.this results will inform future risk stratification, decision making and improve patient's clinical care.this study is an investigator-led, non-commercial, non-interventional study is extremely low risk, or even zero risk.


Eligibility criteria:
inclusion criteria: * patients undergoing any type of endoscopic surgery in an operating theatre and these patients had covid-19 infection either at the time of surgery or within 30 days of surgery. exclusion criteria: * if covid-19 infection is diagnosed \>30 days after discharge, the patient should not be included.
evaluation of salivary level of mir-155 and il-10 in oral lichen planus patients before and after treatment with topical corticosteroid

Conditions: Oral Lichen Planus

Summary: thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients. oral lichen planus patients will be treated with a topical steroid and mir-155 and il-10 will be assessed in saliva before and after 4 weeks of topical steroids use


Eligibility criteria:
inclusion criteria: * patients clinically and histopathologically diagnosed as having atrophic/erosive olp. * patients free from any other oral lesions * cooperative patients who agrees to take the supplied medications. * patients who are systemically healthy exclusion criteria: * patients suffering from any systemic disease. * treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks. * treatment with any oral topical medications for at least four weeks prior to the study. * pregnant and lactating women.
ak104 plus concurrent chemoradiation therapy in esophageal squamous cell carcinoma

Conditions: Esophageal Squamous Cell Carcinoma

Summary: the purpose of this study is to assess the safety and efficacy of ak104 plus concurrent chemoradiation therapy in unresectable locally advanced esophageal squamous cell carcinoma

ak104 10mg/kg plus tc regimen(paclitaxel liposome 135mg/m2, carboplatin auc=5), once every 3 weeks (q3w), induction treatment for 2 cycles; subsequently, ak104 10 mg/kg plus tc regimen(paclitaxel liposome 135mg/m2, carboplatin auc=5) is combined with radiotherapy(50gy/25f) for 2 cycles. assess disease efficiency( objective response rate; disease control rate; duration of overall response; time to resolve) and safety( adverse event).

Eligibility criteria:
inclusion criteria: * unresectable locally advanced esophageal squamous cell carcinoma; ecog ps 0-1; at least one measurable lesion according to resist standard 1.1； not received anti-tumor treatment in the past exclusion criteria: * received immunotherapy in the past； active hepatitis b, hepatitis c and other infectious diseases； severe liver and kidney function, cardiovascular and cerebrovascular abnormalities
effects of buprenorphine/naloxone administered in different ways for treating opioid dependence

Conditions: Opioid-Related Disorders

Summary: buprenorphine is a treatment for opioid dependence. naloxone is given in addition to buprenorphine in order to limit the abuse potential that is commonly associated with buprenorphine. the purpose of this study is to examine the effects of buprenorphine/naloxone when given through different routes and at different doses.

buprenorphine, a mixed agonist-antagonist opioid (or partial agonist), is a safe and effective treatment for opioid dependence. however, there is concern that buprenorphine may be abused due to its high abuse potential. a sublingual buprenorphine/naloxone combination tablet may reduce the risk of abuse associated with buprenorphine alone. the purpose of this study is to characterize the effects of buprenorphine/naloxone in opioid-dependent individuals. this study will last 10 weeks. participants will stay in a residential research unit, and will be maintained on oral hydromorphone (10 mg). during twice-weekly experimental sessions, participants will be randomly assigned to receive either sublingual tablets, intramuscular injections, or a placebo. the 15 conditions studied will include: sublingual or intramuscular buprenorphine/naloxone (1/0.25 mg, 2/0.5 mg, 4/1 mg, 8/2 mg, and 16/4 mg), 0.25 mg of intramuscular naloxone (antagonist control), 10 mg of intramuscular hydromorphone (agonist control), sublingual and intramuscular buprenorphine (8 mg), and placebo.

Eligibility criteria:
inclusion criteria: * currently opioid dependent * in good health, as determined by a pre-participation medical examination * seeking and eligible for methadone maintenance or detoxification treatment exclusion criteria: * significant medical or psychiatric illness, other than drug dependence

Keywords: opiate dependence
the effect of progressıve relaxatıon exercıses

Conditions: Sleep Disturbance; Fatigue

Summary: this study was conducted to evaluate the effect of progressive relaxation exercises applied to nurses working in the intensive care unit three times a week for 1 month on sleep quality and severity of fatigue. the research is a pretest-posttest randomized controlled study with an intervention control group.

the effect of progressive relaxation exercises applied to nurses working in the i̇ntensive care unit on sleep quality and fatique i̇ntensity the study was planned to determine the effect of progressive relaxation exercises applied to nurses working in intensive care units on sleep quality and fatigue intensity. the study will be conducted with a randomized controlled experimental research design in order to evaluate the effect of progressive relaxation exercises applied to nurses working in the intensive care unit on sleep quality and fatigue intensity. this randomized controlled study will be conducted on nurses working in adana city training and research hospital intensive care unit. nurses will be divided into 2 groups as experiment and control. it will be carried out on 60 people in total, 30 for the experimental group, 30 for the control group. progressive relaxation exercises will be applied by nurses for 45 minutes, 3 days a week for an average of 1 month. the data of the study will be collected after the purpose of the study is explained to the nurses and their verbal and written consents are obtained. in the collection of research data, the personal information form prepared by the researchers and containing the introductory information of the nurses, the pittsburgh sleep quality index (pittsburgh sleep quality index scale psqi), the fatigue severity scale for fatigue (fss) will be collected from control and intervention groups through face-to-face interviews. there are a limited number of studies showing the effects of progressive relaxation exercises applied to intensive care nurses on sleep quality and fatigue intensity in our country. with the study, the use of these exercise programs, which can be easily applied by nurses who work under heavy workloads in the intensive care environment, will increase, and it will be ensured that nurses work more fit and efficiently and are supported in terms of sleep fatigue.

Eligibility criteria:
inclusion criteria: * without a psychiatric diagnosis, * having a score of puki ≥5 and yşö≥4, * nurses who volunteered to participate in the study were included in the research sample. exclusion criteria: * experience of working in intensive care for less than 3 months, * using antidepressant, antihistamine, diuretic, hypnotic, benzodiazepine, antidepressant, anxiolytic and narcotic analgesics that affect sleep quality, * pregnant nurses were not included in the research sample.

Keywords: nurse progressive relaxation sleep intensive care fatigue
study of hernia repair utilizing the bard ventrio hernia patch

Conditions: Ventral Hernia

Summary: this study will collect data on patients undergoing hernia repair using the bard ventrio hernia patch. the study will evaluate hernia recurrence rates, operating time, quality of life and complications associated with the device and surgical procedure.


Eligibility criteria:
inclusion criteria: 1. male or female, age ≥ 18 2. be able to undergo study procedures 3. have signed an informed consent form (icf) 4. be diagnosed with a ventral hernia requiring an open surgery for repair. exclusion criteria: 1. patient is participating in another device or drug study. 2. patient exhibits clinical symptoms indicating infected hernia site. 3. patient currently has a clean contaminated or contaminated site. 4. patient has a life expectancy less than 2 years at the time of enrollment. 5. anything in the opinion of the investigator that would preclude the use of the ventrio hernia patch, or preclude the subject from completing the follow-up requirements.

Keywords: hernia open
substudy of protocol nct03843957 - effect of mpath on screening for depression, fall risk, and safety

Conditions: Depression

Summary: this is a sub-study for data analysis of data collected as part of the larger randomized controlled trial "effectiveness and implementation of mpath-crc" (nct03843957) to determine if self-administered screening with an ipad increases the detection of patients with depression, falls, and intimate partner violence.

as part of the parent study (nct0343957), investigators developed an ipad program called mpath that patients use at their primary care clinician's office to encourage colorectal cancer screening. to encourage practices to use mpath with every patient, the investigators included in the program the health system's required screening items for depression, fall risk, and intimate partner violence, thereby offloading this routine task from clinical staff. it is possible that mpath will increase detection of depression, fall risk, and intimate partner violence because: 1) mpath systematically asks these screening items of all patients, and 2) patients may feel more comfortable answering these items on an ipad survey than during an in-person interview. to determine the effect of mpath on the performance of this screening, investigators will examine a limited use dataset comparing the 2 months before a clinic started using mpath to the 2 months after the clinic began using mpath. because clinics may need some time to fully adopt mpath, investigators will exclude the first two weeks following the launch of mpath.

Eligibility criteria:
inclusion criteria: * age 18 or older * completed a provider visit at the study clinic during the 60 days prior to the clinic launching the mpath program (the "pre" time period), or completed a provider visit at the study clinic during days 14 - 73 after the launch of mpath (the "post" time period) * have a preferred language of english or spanish exclusion criteria: • requiring a language interpreter for a language other than spanish

Keywords: fall risk intimate partner violence
homocystinuria: treatment with n-acetylcysteine

Conditions: Homocystinuria

Summary: the purpose of this study is determine if oral n-acetylcysteine is effective in lowering homocysteine in individuals with homocystinuria.

homocystinuria (mim 236200) due to cbs deficiency is the most common inborn error of sulfur amino acid metabolism with severe clinical manifestations. we propose: 1. an open-label pilot study of n-acetylcysteine (nac) to lower plasma homocysteine levels in those that have not responded to conventional treatment which includes betaine (cystadane®, orphan medical inc.), which while lowering hcy levels does not normalize it, and is very expensive. there are no known contraindications to nac used for nutritional supplementation and it is relatively inexpensive. oral nac has reduced total plasma homocysteine in healthy subjects in a dose-dependent fashion. 2. measurement of flow-mediated vasodilation of the brachial artery (endothelial function) in response to nac treatment. endothelial dysfunction is a precursor of atherogenesis. 3. sequencing the cbs gene in these individuals in order to identify novel mutations causing homocystinuria and identify polymorphisms in other genes that may affect response to treatment.

Eligibility criteria:
inclusion criteria: * homocystinuria (lens dislocation and hyperhomocysteinemia) * age ≥ 18 (the age of majority in canada) exclusion criteria: * nursing mothers or pregnant women * chronic liver disease * taking nitrates * cystine stone formers * history of active peptic ulcer disease * subjects receiving carbamazepine and metoclopramide * use of other products containing cysteine or n-acetylcysteine (e.g. nebulized nac, cysteine supplements, methionine restriction) * hypersensitivity to any ingredient in the study product * clinically significant, abnormal laboratory test on screening (visit 2) other criteria: * women of child-bearing capacity must be using an acceptable method of birth control and have a negative pregnancy test before being enrolled
optimal strategy for side branch stenting in coronary bifurcation lesion

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to establish the optimal strategy for side branch stenting in coronary bifurcation lesion.

the purpose of this study is to evaluate the relative efficacy and safety of conservative strategy compared to aggressive strategy for side branch stenting in coronary bifurcation lesion.

Eligibility criteria:
inclusion criteria: * parent vessel diameter stenosis \> 75% * parent vessel diameter stenosis 50% - 75% with angina and/or objective evidence of ischemia in the non-invasive stress test * the reference diameter of both branches more than 2.3 mm by visual estimation exclusion criteria: * cardiogenic shock * st-elevation myocardial infarction within 48 hours of symptom onset * left ventricular dysfunction (echocardiographic left ventricular ejection fraction \< 25%) * graft vessels * patients who have to receive clopidogrel due to other conditions * patients who have to receive warfarin, cilostazol or other antiplatelet therapy * hypersensitivity to clopidogrel or aspirin * expectant survival less than 1 year * women who plan to become pregnant * patients with bleeding diathesis (coagulopathy, thrombocytopenia or platelet dysfunction, gastrointestinal or genitourinary bleeding within the prior 3 months) * patients who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period.

Keywords: angioplasty, transluminal, percutaneous coronary
comparison of biochemical changes in patients with trochanteric region fracture fixation with dhs versus pfn

Conditions: Hip Fractures

Summary: hip fractures are one of the most frequent fractures in older adults. there is still controversy which surgical strategy is the best option for treatment of hip fractures especially trochanteric region fractures. surgical intervention that follows hip fracture induces biochemical, physiological and fibrinolytic changes that are so-called "second hit phenomenon" which trigger systemic inflammatory response syndrome. the investigators are aiming to study this phenomenon after two different surgical procedures and help surgeons in everyday practice to choose the most suitable surgical treatment for patients with trochanteric region fracture and give the scientific community more evidence which methods is better since there is still controversy.


Eligibility criteria:
inclusion criteria: * patients with trochanteric region fractures ao/ota 31.a1-31.a2 * time from fracture till surgery up to 1 week * american society of anesthesiologists classification (asa) i-iii * willing to participate exclusion criteria: * polytrauma patients * open fractures * existing local or systemic infection * pre-existing coagulatory disorder * existing malignancy * corticosteroid use * systemic inflammatory disease * voluntary withdraws of the patient

Keywords: hip fractures inflammatory response interleukin-6 comparative study
oral pathology asynchronous telementoring pilot study

Conditions: Oral Cancer

Summary: the purpose of the proposed research project is to evaluate and enhance the feasibility and acceptability of integrating a tele-mentoring component into the identification of oral lesions at the 6 dental clinics of family health centers at nyu langone (fhc), a federally qualified health center (fqhc) in brooklyn, ny.

the tele-mentoring intervention involves training dental faculty members and residents to use intraoral cameras to take photographs of oral lesions and place them in the dentrix electronic health record (ehr), along with descriptions of the lesions. using a mixed-methods approach, the study will evaluate and enhance the feasibility and acceptability of integrating a tele-mentoring component into the identification of oral lesions at the 6 fhc dental clinics.

Eligibility criteria:
inclusion criteria: dental patients will be eligible for study participation if they meet the following criteria: 1. greater than or equal to 18 years of age. 2. live in any of the 5 boroughs of new york, ny and visit a participating fhc dental clinic for routine dental care. 3. able and willing to provide informed consent, have their oral lesion(s) photograph(s) and accompanying data entered into the dentrix ehr, and participate in an exit interview. dental providers will be eligible for study participation if they meet the following criteria: 1. greater than or equal to 18 years of age. 2. be employed as a dentist or placed as a dental resident at a participating fhc dental clinic. 3. able and willing to provide informed consent and participate in feasibility testing (provider survey or semi-structured interview). exclusion criteria: dental patients will be excluded from study participation if they meet the following criteria: 1. have an acute or terminal illness or a serious mental illness or any other severe health condition(s) that might preclude visiting an oral health care provider. 2. are currently participating in another oral health study. dental providers will be excluded from study participation if they meet the following criteria: 1. have an acute or terminal illness or a serious mental illness or any other severe health condition(s) that might preclude them from completing the feasibility testing.
increased body temperature post tracheostomy: a retrospective study

Conditions: Tracheostomy Complication

Summary: tracheostomy is one of the most common procedures in intensive care units. post-tracheostomy increased body temperature within 24 hours is common. however, frequently sepsis workup is performed along with initiation of broad spectrum antibiotic therapy. we will investigate the incidence of post tracheostomy fever and whether retrospectively the increased temperature indicated development of sepsis or not. the study is retrospective and will be based on data collection.


Eligibility criteria:
inclusion criteria: patients admitted to the icu from 1.2020 to 1.2025 who underwent tracheostomy during icu admission - exclusion criteria: patients who did not fullfil the above criteria -
safety and feasibility of kefir administration in critically ill adults

Conditions: Critically Ill

Summary: the purpose of this study is to evaluate the safety and feasibility of kefir administration in critically ill adults.


Eligibility criteria:
inclusion criteria: * critically ill adult patients receiving antibiotics. * functional gi tract (able to tolerate oral diet or tube feeding). exclusion criteria: * received antibiotics for \>72 hours prior to enrollment. * known immunosuppression (due to medications including chronic steroids, tnf-alpha inhibitors, monoclonal antibodies, immunosuppressive antimetabolites, etc.). * compromised gut integrity (bowel resection, gi malignancy, gi bleed, inflammatory bowel disease). * history of cdi within 60 days. * liver failure or pancreatitis. * dairy intolerance or milk allergy. * patients consuming probiotics at baseline. * artificial heart valve. * extremely poor prognosis and not expected to survive the treatment period.
artificial intelligence based program to classify oral cavity findings based on clinical image analysis

Conditions: Oral Cancer; Oral Lichen Planus; Fordyce Granule; Leukoplakia; Erythroplakia; Leukoedemas, Oral; Lichenoid Reaction

Summary: this study aims to develop an ai program that can classify oral findings into normal/variation of normal or an oral disease by clinical photos analysis, aiding in lowering the percentages of false positive and false negative diagnosis of oral diseases.

early diagnosis of oral lesions, particularly oral cancer, is crucial for enhancing prognosis, facilitating early intervention and care with the intention of lowering disease-related mortality. since conventional oral examination (coe) is the most used method in identifying oral lesions, the average dental practitioner's experience is a decisive factor in early diagnosis. visual examination lacks specificity and sensitivity since its highly subjective. unfortunately, studies show that the majority of dentists lack expertise in early detection of the disease, resulting in false negative diagnosis of oral lesions. general practitioners are found to either delay the referral of a suspected oral lesion to an oral medicine specialist, or referring numerous false positive cases, unnecessarily pushing the patients into a state of anxiousness and cancer phobia. false positive referrals overburden the specialists, which will eventually cause delayed diagnosis of true positive cases due to the oversaturation with false positive ones. diagnostic research scope shifts towards noninvasive, easy chair side methods with higher accuracy for early detection of oral lesions. recent approaches towards using machine based programs indicate that this machine-learning method may be useful in the detection and diagnosis of oral cancer.

Eligibility criteria:
inclusion criteria: * patients above 18 years old * candidates with normal oral cavity findings * candidates with variations of oral cavity findings * candidates with different oral lesions exclusion criteria: • patients less than 18 years old
study in patients undergoing debridement, antibiotics, and implant retention (dair) for treatment of a periprosthetic joint infection (pji) occurring after total knee arthroplasty (tka)

Conditions: Joint Infection

Summary: the purpose of this study is to learn about the safety and effects of plg0206 for treating periprosthetic joint infections (pji) in conjunction with the dair (debridement, antibiotics and implant retention) surgical procedure for patients with periprosthetic joint infections (pji) after total knee arthroplasty (tka) .

peptilogics, inc. is developing plg0206 for the treatment of pjis. plg0206 is an engineered antibacterial peptide (eap) based on naturally-occurring antimicrobial peptides (amps). recent work on plg0206 has documented that plg0206 is a highly effective anti-biofilm agent, in addition to its established activity against planktonic staphylococcus, both in vitro and in a murine animal model of pji. plg0206 will be investigated in this study for treatment of pji in conjunction with the dair procedure followed by the 6-week course of antimicrobial therapy that is standard-of-care (soc) in this indication. patients will be followed for approximately 1 year post treatment.

Eligibility criteria:
inclusion criteria: * patients with well-fixed prosthesis; * patients who have a pre- or intra-operative diagnosis of tka-pji exclusion criteria: * patients for whom a dair procedure is not indicated; * patients with loose prosthesis and/or surgical treatment requiring removal of well-fixed, non-modular implants at screening; * patients with previous history or presence of osteomyelitis in the index limb; * patients who have uncontrolled diabetes mellitus; * patients with body mass index \>50 kg/m2 at screening; * patients who are immunosuppressed; * patients who require therapeutic anticoagulation and/or antiplatelet therapy

Keywords: pji knee infection