Kornimate/medical-research-clean huggingface dataset:
orwh:scor - sex/gender factors affecting women's health

Conditions: Urinary Tract Infection

Summary: this project is the clinical project of a specialized center of research (scor) proposal which is designed to further our understanding of urinary tract infection (uti) in women. acute uncomplicated urinary tract infections (utis) occur in an estimated 7-11 million women each year, and the annual costs of caring for these women are thought to approach $1.6 billion. approximately 20-30% of women suffer from frequent recurrent infections. utis in young women result in substantial symptoms, time lost from work, and medical costs. an improved understanding of the mechanisms underlying utis could result in new approaches to their prevention and reduced numbers of women with infections and the amount of antibiotics use. in this project we seek a better understanding of the causes of uti. most experts believe that vaginal colonization with uti-causing bacteria from the rectal flora precedes colonization of the urethra (the tube from the bladder for urination) and bladder and subsequent uti, but the relationships between these events has not been established. moreover, recent information from studies in mice strongly suggest that persistent bladder infection follows an initial bladder infection. in this project, we will prospectively follow a large group of women with recurrent uti to determine: 1) the relationships in time between vaginal colonization with a uti-causing bacteriuria, asymptomatic bacteriuria (bacteria in the bladder but without any uti symptoms) and symptomatic uti, and 2) the presence of persistent bacteria in the bladder following the symptomatic uti at entry into the study and whether such bacteria are related to later utis that are caused by the same bacteria that caused the uti at entry into the study. we will thus be able to determine the relative importance of vaginal colonization vs. persistent infection of the bladder as the origin of the bacteria causing recurrent uti. uti-causing bacteria cultured from women with symptomatic uti and asymptomatic bacteriuria will undergo studies by dr. scott hultgren's group at washington university in project 1 to identify unique genes that may help us understand why some bacteria cause symptoms and others do not. the effect of bacteria causing uti in these women on host response will also be determined by studies by dr. jeff gordon's laboratory at washington university in project 3. a better understanding of the molecular and epidemiologic basis of uti is critical in developing the best possible prevention and management strategies.


Eligibility criteria:
* healthy women with bladder infection who have a history of at least one previous uti in the past 12 months. * women must be able to provide written informed consent. * they must not be pregnant or planning on becoming pregnant in the next 3 months, have no chronic illness, have no known anatomic or functional abnormalities of the urinary tract and not have any symptoms suggestive of kidney infection.

Keywords: urinary tract infection
efficacy of a combined ergonomic health promotion intervention on employee health

Conditions: Sedentary; Overweight

Summary: our objective in this pilot study is to test the combined effect of a) replacing office workers' sedentary workstations with active workstations (lifebalance station) and b) optimizing computer workstation ergonomics on daily occupational sedentary time, cardiometabolic risk factors, musculoskeletal symptom health outcomes and work productivity.

primary aim: to compare the effects of providing sedentary employees with seated active workstations in combination with an ergonomic intervention and regular motivational emails (experimental group) against the ergonomic intervention and regular emails only (active control group) on occupational sedentary behavior over 16 weeks. hypothesis: the addition of a seated active workstation will result in significant reductions in daily occupational sedentary time compared to the active control group. secondary aims: to compare the effects of the experimental group against the active control group on secondary measures of cardiometabolic disease risk factors, musculoskeletal discomfort, cognitive function and work productivity. hypothesis 1: the experimental group will result in reduced cardiometabolic disease risk, musculoskeletal discomfort and work limitations compared to the active control group.

Eligibility criteria:
inclusion criteria: * we will recruit overweight/obese (body mass index 25.0-40.0 kg/m2) adults (18-65 years) working in full-time (minimum 35 hours/week), sedentary (self-report sitting \>75% work time) occupations at an independent work site. exclusion criteria: * working in an office that will not meet the space or electrical requirements of the active workstation, acute or chronic illness not under treatment of a provider, orthopedic limitations that prohibit physical activity, current or planned pregnancy, hospitalization from a physical or mental disorder in the past six months and/or taking medication that may impair physical activity
efficacy and safety of xiaflex injection for treatment of dupuytren's contracture of the thumb

Conditions: Dupuytren's Contracture

Summary: this study will evaluate the efficacy and safety of clostridial collagenase injections for treatment of dupuytren's contracture of the thumb and first web space. the investigators hypothesis is that clostridial collagenase will have safety not significantly different to that demonstrated in phase iii clinical trials, and will be effective in significantly reducing the degree of thumb contracture.


Eligibility criteria:
inclusion criteria: * adult subjects (\> 18 years) of either gender with an mp and/or ip joint contracture and a palpable cord of \> 20 degrees of the thumb * first web space contracture with a palpable cord due to dupuytren's contracture exclusion criteria: * prior surgical, percutaneous needle aponeurotomy or xiaflex treatment for dupuytren's contracture of the same thumb. * any subject using anti-coagulant therapy other than low dose aspirin (up to 150mg/day). * any subject in the opinion of the md investigators with chronic, severe or terminal medical illness which would make them unsuitable for study participation. * any subject with known allergy to xiaflex (clostridial collagenase). * pregnant or nursing female * any subject who cannot conform to the study visit schedule

Keywords: dupuytren dupuytren's disease
optimized oxygen delivery during general anesthesia in newborn infants

Conditions: Oxygen Toxicity; Oxidative Stress

Summary: an open randomized control trial investigating the delivery of two levels of inspired oxygen to newborn infants during general anesthesia.

eligible infants are infants of less than 44 weeks postconceptional age and without pulmonary disease or demand for supplemental oxygen or assisted ventilation. control subjects receive current standard of care (anesthesia induction/pre-oxygenation with 80%, maintenance of anesthesia with 40%, and recovery with 80% inspired oxygen). intervention subjects are maintained on room air throughout the procedure and supplemental oxygen added only if necessary according to the pre-specified oxygen saturation target. subjects are monitored according to clinical protocols and with cerebral oximetry (nirs), transcutaneous measurement of partial pressure of oxygen (po2), and blood-gas analyses. blood and urine samples are collected for later analysis of markers for oxidative stress.

Eligibility criteria:
1. newborn less than 44 weeks postconceptional age 2. no pulmonary disease, no oxygen requirement, or assisted ventilation 3. no genetic syndrome

Keywords: newborn anesthesia oxygen hyperoxia
reinforcement-based treatment and abstinence-contingent housing for drug abusers

Conditions: Drug Abuse

Summary: purpose of the project is to examine the effectiveness of reinforcement-based treatment (rbt) on drug abuse and psychosocial outcomes of iner city opiate abusers who have recently completed a brief detoxification.

participants are randomized into one of 3-groups: 1) those receiving intensive behavioral therapy plus abstinence-contingent housing, 2) those receiving recovery housing alone, and 3) those receiving standard care (referrals to community providers). for the two groups receiving recovery housing, rent payment is provided for a period of 3 months, as long as the participant remains drug-free.

Eligibility criteria:
inclusion criteria: * opiate dependent agree to live in recovery housing exclusion criteria: * acute psychiatric disorder pregnant over 65
mental and psychological problems and insomnia disorder of medical staff in hospital with infected covid-19 patients

Conditions: Depression Unipolar; Insomnia

Summary: the objective of this study is to clarify the severity of psychological problems and insomnia and the two's relationship with time of hospital medical staff in hospital where its staff are infected with covid-19.

a cross-sectional questionnaire survey method was adopted to conduct investigations of medical staff in the researched hospital within one week (baseline) and one year (follow-up) after the discovery of covid-19 infection cases. 360 subjects were included in the baseline. then, after one year, 199 subjects who participated in the survey at baseline were included as follow-up. the hads, asds and isi scales were used to assess the anxiety and depression level, acute stress disorder symptoms, and the severity of insomnia of hospital medical staff; self-made questionnaires was to collect demographic information and descriptive content. comparing the follow-up medical staff with the baseline, the total scores of asds, hads and isi, each item scores on the asds, hads and isi. all of above scales are compared between the quarantined and non-quarantined groups, different quarantined groups (home, hotel, hospital) and non-quarantined groups.

Eligibility criteria:
inclusion criteria: * all medical staff of a third-level general hospital in beijing who discovered a sporadic case of covid-19 infection; volunteer to participate in surveys and follow-ups exclusion criteria: * incomplete information fills in, which affects the result analysis
pertussis acellular vaccine adjuvanted with tql1055

Conditions: Pertussis

Summary: this is a phase 1 study to evaluate the safety and immunogenicity of the semisynthetic saponin adjuvant tql1055 administered in combination with an acellular pertussis vaccine.

the recent increase in the incidence of pertussis has prompted the need for improvements to current acellular pertussis vaccines. use of novel adjuvants is one approach to such improvement. tql1055 is a rationally designed, semisynthetic analog of the licensed quillaja saponin (qs)-21. it has been designed to maintain adjuvant activity with improved tolerability and greater ease of manufacture. this is a phase 1, randomized, double blind, active-controlled sequential-group study, designed to evaluate the safety, tolerability, and immunogenicity of the combination of tql1055 and acellular pertussis vaccine. the dose of tql1055 will increase by group.

Eligibility criteria:
key inclusion criteria: * 18 to 50 years of age * general good health * bmi between 17 and 35 kg/m2 * not of childbearing potential or using adequate contraception key exclusion criteria: * pregnant or lactating * prior medical condition that could adversely affect subject safety * clinically significant abnormal laboratory parameter * current acute febrile illness * contraindication to intramuscular injection * contraindication to pertussis vaccination * received pertussis vaccine within 3 years

Keywords: vaccine adjuvant
study of peri-operative and acute outcomes after robotic-assisted cholecystectomy

Conditions: Cholecystectomy

Summary: a multi-center retrospective chart review of short-term outcomes associated with robotic-assisted cholecystectomies performed during regular hours and after-hours.

the study is a retrospective multi-center chart review study of short-term patient outcomes through 30 days after robotic-assisted cholecystectomies performed during regular hours and after-hours. the primary outcomes include the rate of conversion to open, rate of intra-operative adverse events, the rate of post-operative adverse events relating to the cholecystectomy within 30 days, and re-admissions and re-operations relating to the cholecystectomy within 30 days. in addition, operative time, the rate of use of intra-operative imaging, and the hospital length of stay will be collected as secondary outcomes.

Eligibility criteria:
inclusion criteria: * subject between 18 and 80 years of age at the time of surgery. * subject underwent a robotic-assisted cholecystectomy during the study time period. exclusion criteria: * cholecystectomy was performed as a secondary procedure.
water method in elder patients with unsedated colonoscopy

Conditions: Adenoma; Pain

Summary: water method with water exchange has been shown to reduce medication requirement and pain experienced during colonoscopy. it increases the success rate of cecal intubation in sedated and unsedated patients undergoing screening colonoscopy. exchange of water during scope insertion minimizes distension of the colonic lumen and decreases loop formation. exclusion of air from the colon during insertion by omission of air insufflations and suction removal of residual air prevent elongation of the colon. these maneuvers facilitate colonoscopy insertion in average patients and may enhance the success of difficult colonoscopy. older age is independently associated with incomplete colonoscopy, the investigators postulate that these patients may benefit from using the water method for colonoscopy. in this proposal the investigators test the hypothesis that compared with conventional air insufflations the water method with water exchange significantly enhances the success rate of cecal intubation in elder patients. the aim of the study is to compare the outcome of colonoscopy using the water method versus the conventional air method in elder patients. the primary outcome is cecal intubation success rate. the secondary outcomes include cecal intubation time, maximum pain score during colonoscopy, overall pain score after colonoscopy and adenoma detection rate.


Eligibility criteria:
inclusion criteria: * patients over the age of 70 exclusion criteria: * history of colorectal surgery * severe colonic stricture or obstructing tumor * patients who cannot give informed consent and those who are hemodynamically unstable

Keywords: colonoscopy elder patient water unsedated
copeptin in adolescent participants with type 1 diabetes and early renal hemodynamic function

Conditions: Diabetes Mellitus, Type 1; Nephropathy; Diabetic Nephropathies; Juvenile Diabetes; Diabetes Mellitus Complication; Autoimmune Diabetes; Type 1 Diabetes Mellitus

Summary: over 1.25 million americans have type 1 diabetes (t1d), increasing risk for early death from cardiorenal disease. the strongest risk factor for cardiovascular disease (cvd) and mortality in t1d is diabetic kidney disease (dkd). current treatments, such as control of hyperglycemia and hypertension, are beneficial, but only partially protect against dkd. hyperfiltration is common in youth with t1d, and predicts progressive dkd. hyperfiltration is also associated with early changes in intrarenal hemodynamic function, including increased renal plasma flow (rpf) and glomerular pressure. intrarenal hemodynamic function is strongly influenced by the renin-angiotensin-aldosterone system (raas), which is also considered a key player in the pathogenesis of dkd. preliminary data demonstrate differences in intrarenal hemodynamic function and raas activation in early and advanced dkd in t1d. however, the pathophysiology contributing to the differences observed in raas activation and intrarenal hemodynamic function in t1d are poorly defined animal research demonstrates that arginine vasopressin (avp) acts directly to modify intrarenal hemodynamic function, but also indirectly by activating raas. preliminary data suggest that elevated copeptin, a marker of avp, which predicts dkd in t1d adults, independently of other risk factors. however, no human studies to date have examined how copeptin relates to intrarenal hemodynamic function in early dkd in t1d. a better understanding of this relationship is critical to inform development of new therapies targeting the avp system in t1d. accordingly, in this study, the investigators propose to define the relationship between copeptin and intrarenal hemodynamics in early stages of dkd, by studying copeptin levels, renal plasma flow, and glomerular filtration in youth (n=50) aged 12-21 y with t1d duration \< 10 y.


Eligibility criteria:
inclusion criteria: * antibody+ t1d with \<10 yr duration * age 12-21 years * bmi ≥ 5%ile * weight\ 57 lbs. * no anemia * hba1c \<12% exclusion criteria: * severe illness, recent diabetic ketoacidosis (dka) * estimated glomerular filtration rate (egfr) \ 1.5mg/dl or history of acr≥300mg/g * anemia or allergy to shellfish or iodine * pregnancy or nursing * mri scanning contraindications (claustrophobia, implantable devices, \>350 lbs) * angiotensin-converting enzyme (ace) inhibitors, angiotensin receptor blockers (arb), diuretics, sodium-glucose co-transport (sglt) 2 or 1 blockers, daily nsaids or aspirin, sulfonamides, procaine, thiazolsulfone or probenecid, atypical antipsychotics and steroids
a neurobiological model of anhedonia

Conditions: Anhedonia; Depression

Summary: the purpose of this research study is to better understand anhedonia in major depressive disorder by investigating the reward-related neural and inflammatory correlates.

background: despite extensive research on the treatment of major depressive disorder (mdd) relapse rates are as high as 80%. of those, 30-40% fall into the severe spectrum called treatment resistant depression (trd) as they fail to respond to at least two lines of antidepressant treatment interventions. trd has been linked with anhedonia, the inability to experience pleasure or interest in usually enjoyable activities. the neurobiology of anhedonia is poorly understood with recent literature examining an inflammatory association and linking it to deficits in reward-related brain circuitry. the present study examines neurobiological correlates of anhedonia in mdd and trd, specifically c-reactive protein (crp), il-6 and ventral striatal (vs) activity. the study also explores whether vs activity mediates the association between inflammation and anhedonia.

Eligibility criteria:
inclusion criteria: * current diagnosis of mdd based on the mini international neuropsychiatric interview (mini) * for treatment resistant depression participants: unsuccessful treatment with at least 2 types or doses of antidepressant medication treatment * right-handed * capacity for informed consent * score a 9 or higher on the madrs exclusion criteria: * comorbid bipolar disorder * substance use disorder in the last 12 months * schizophrenia, and other psychotic disorders * comorbid illness such as endocrinological illness (e.g. cushing's disease) rheumatologic illness (e.g., systemic lupus erythematosus, current treatment with glucocorticoids), and autoimmune diseases (e.g. psoriasis) * pregnancy * daily nsaid or aspirin use and any metallic implant * visual/hearing impairments that would keep participant from being able to complete tasks

Keywords: depression anhedonia reward related neural circuitry inflammation
studying the clinical research experiences of patients with ptsd

Conditions: PTSD

Summary: clinical research participation percentages haven't always been fully representative of a given demographic. the goal is to find out which aspects of a clinical study may make it more difficult for patients to take part or see it through. the data will be evaluated through different demographic lenses and identify trends that could help improve the experience of future ptsd patients during clinical trials.


Eligibility criteria:
inclusion criteria: * must have a medical diagnosis of ptsd that has been confirmed by a physician. * aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed. * willing and able to comply with scheduled visits, treatment schedule, laboratory tests and other requirements of the study. exclusion criteria: * pregnant or lactating woman * patients with any significant history of non-compliance to medical regimens or with inability to grant a reliable informed consent. * known medical condition that, in the investigator's opinion, would increase the risk associated with study participation or study drug(s) administration or interfere with the interpretation of safety results

Keywords: ptsd
temporomandibular dysfunction affects neck disability, headache, anxiety, and sleep quality in women: a cross-sectional study

Conditions: Temporomandibular Disorders; Headache; Neck Disorder; Anxiety; Sleep Disorder

Summary: the temporomandibular joint (tmj), is the only movable joint between the joints in the head and neck system. it is a component of the chewing system and is involved in important functions such as speech, swallowing, taste and breathing. temporomandibular dysfunction (tmd) is the general name given to various musculoskeletal problems seen in the stomatognathic system, mostly affecting the masticatory muscles and/or tmj. tmd is the second most common musculoskeletal pain after chronic low back pain. patients with tmd may also complain of other musculoskeletal problems, craniocervical problems, sleep problems, and anxiety disorders. the aim of this study is to investigate, compare and examine the relationship between neck dysfunction, headache and temporomandibular dysfunction severity, anxiety and sleep quality in female individuals.


Eligibility criteria:
inclusion criteria: * between 18 and 65 years * temporomandibular disorders more than 6 months * volunteering exclusion criteria: * cranio-cervical trauma and temporomandibular operation history * infection * 20-40 points from fonseca anamnestic index 20-40 points