Kornimate/medical-research-clean huggingface dataset:
effects of an activity control system in patients with diabetes: a randomized controlled trial

Conditions: Diabetes Mellitus, Type 2

Summary: using a smart device (beprevent) to monitor activities of daily living improves the lifestyle of patients with dm2

a 6-month randomized clinical trial to evaluate a home activity control system (beprevent) in the management of the patient with dm2, through the individualized labeling of objects related to them. the study will include 20 patients with dm2 (10 in the intervention group and 10 in the control group) who live alone or with people who can´t move on their own. data will be recorded to measure the degree of satisfaction of professionals and participants in the study, and clinical and epidemiological data at the start of the study (in its baseline situation) and at the end of the study (at 6 months), to assess the changes produced and compare them between both study groups.

Eligibility criteria:
inclusion criteria: * ≥ 18 years, with the ability to give informed consent * patient who has autonomy to carry out activities of daily living (barthel = 100) * patient diagnosed with diabetes mellitus * patient in pharmacological treatment * to live alone or with a person who cannot move on their own * they do not plan to change their address in the 6 months after inclusion in the study exclusion criteria: • dm2 patients whose most recent hba1c value is ≤7%

Keywords: artificial intelligence diabetes mellitus self-care telemedicine
clinical validation of new breathing sensors in patients with respiratory insufficiency

Conditions: Respiratory Patients

Summary: the nxt_sleep study, bringing together industry partners, research groups and (home) care providers, tackles will develop a next generation sleep-monitoring platform that consists of less obtrusive sensors, and that delivers complete and useful information regarding the physiological parameters relevant for sleep-related breathing disorders. these new and innovative sensors need to be validated in a clinical setting where they will be benchmarked with the classical sleep monitoring systems. in order to compare the novel sensors with the classical monitoring system, the investigators use existing technologies that capture simultaneously the acquired signals of different physiological parameters relevant for sleep-related breathing disorders.

sleep-related breathing disorders are recognized as major risk factors for mortality due to their effect on the cardiovascular system. currently, these sleeping disorders are diagnosed using polysomnography (psg), which is a sleep test that monitors different physiological signals such as heart rate, respiration, ecg, muscle tone and eye movement. although polysomnography is an important diagnostic tool for sleep medicine, it is an uncomfortable and costly procedure, especially when multiple nights of observation are required. in order to reduce costs and improve patients comfort, different home monitoring systems (using different numbers and type of sensors) have been introduced to the market, but those focus especially on self-screening and collect general sleep information. in addition to increasing comfort and reducing costs, the diagnostic capabilities of psg need to be enhanced. this can be achieved by adding novel sensors that may capture new information and improve the measurement of vital physiological parameters during sleep

Eligibility criteria:
inclusion criteria: * patients who are hospitalized for their respiratory disease * written informed consent obtained exclusion criteria: * patients with an uncontrolled disease or any condition that might, in the judgement of the investigator, place the patient at undue risk or potentially comprise the results of interpretation of the study

Keywords: sleep sleep- related breathing disorders respiratory pathology
randomized, placebo-controlled study of leptin for the treatment of hiv lipodystrophy and metabolic syndrome

Conditions: HAART-induced Lipodystrophy and Metabolic Syndrome

Summary: the purpose of this study is to examine whether replacing leptin to normal levels can reverse the changes in fat distribution, lipid profile, and other metabolic problems associated with highly active antiretroviral therapy (haart)-induced lipodystrophy and metabolic syndrome in hiv patients.

exposure to hiv medications has been associated with metabolic changes including generalized fat depletion (lipoatrophy), high triglyceride levels, and in some patients, high sugar levels or diabetes. this syndrome is associated with a deficiency of leptin, a hormone produced by fat cells. recent studies involving leptin administration to patients with congenital lipoatrophy have shown dramatic improvements in metabolic parameters such as insulin resistance and hyperlipidemia. leptin administration to patients with haart-induced lipoatrophy may also lead to significant improvements in the metabolic abnormalities found in these hiv+ patients. the aims of this study are to examine the effect of leptin administration on insulin resistance and other parameters of the metabolic syndrome in hiv patients with haart-induced lipoatrophy. comparison: leptin-treated group to placebo-treated group

Eligibility criteria:
inclusion criteria: * at least 18 years old * documented hiv infection * exposed to at least 6 months of cumulative highly active antiretroviral medications for hiv * developed fat depletion after starting hiv medications * low leptin level in the blood * fasting triglyceride level \> 300 mg/dl exclusion criteria: * active infectious diseases, except hiv * diabetes prior to starting hiv medications * alcohol or drug abuse * triglyceride level \> 1000 mg/dl * significant kidney, liver, or thyroid dysfunction * cancer or lymphoma * pregnancy or planning to become pregnant during the study

Keywords: leptin lipodystrophy insulin resistance hyperlipidemia metabolic syndrome
interest of medical hypnosis in anxious patients treated by radiotherapy

Conditions: Solid Tumor

Summary: this phase ii, randomized, non-comparative and monocentric study aims to evaluate the interest of medical hypnosis in the management of anxiety in patients who are moderately anxious, anxious or very anxious during their radiotherapy treatment. 45 patients will be randomized into the following arms: * arm a (standard): relaxation with music listening during radiotherapy treatment * arm b (experimental): relaxation with music listening and hypnosis during radiotherapy treatment for the study each patient will be followed during 2 months.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years at the time of enrollment into the study. 2. patient with localized or metastatic solid malignant tumor. 3. patient being followed for the cancer pathology at iuct-o and to receive, for the first time in the follow-up, treatment by radiotherapy (radiotherapy treatment should not have been initiated prior to inclusion in the study). 4. patient for whom radiotherapy treatment includes at least 15 sessions of radiation therapy. 5. patient defined as moderately anxious, anxious or very anxious after completing the stai-y self-assessment questionnaire (i.e. ≥ 46 score at inclusion). 6. ecog patient ≤ 2. 7. patient who signed informed consent prior to inclusion in the study and prior to any specific study procedures. 8. patient affiliated to a social health insurance in france. exclusion criteria: 1. patient doesn't understand the french language. 2. patient with psychiatric disorders requiring antidepressant or antipsychotic treatment. 3. patient with hearing problems. 4. pregnant or breastfeeding women. 5. any psychological, family, geographical or sociological condition that prevents compliance with the medical follow-up and/or procedures of the study protocol. 6. patient who has forfeited his/her freedom by administrative or legal award or who is under legal protection (curatorship and guardianship, protection of justice).

Keywords: solid tumor radiotherapy hypnosis anxiety music listening
program for the introduction into clinical practice of the principles of personalized and preventive medicine based on the isolation of gene polymorphism in schizophrenia in people of the kazakh ethnic group

Conditions: Schizophrenia

Summary: this is a gwas study that aims to identify possible candidate genes associate to schizophrenia by exploring single nucleotide polymorphism (snp) in a group of schizophrenia, in the kazakh population. the investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find snp significantly associated with schizophrenia

a genome-wide association study (gwas) is an approach used in genetics research to associate specific genetic variations with particular diseases. the method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Eligibility criteria:
inclusion criteria: * persons of kazakh nationality having this ethnicity in the 3rd generation * age from 18 to 65 years old; * the dispensary in a psychiatric institution at the place of residence with a diagnosis of "paranoid schizophrenia"; * the duration of the disease is at least 1 year (from the moment of taking under dispensary supervision): * absence of severe and chronic somatic diseases; * absence of severe and chronic neurological diseases; * absence of comorbid drug addiction pathology; * signed informed consent to conduct this study exclusion criteria: * persons of non-kazakh nationality and kazakh nationality, not confirmed until the 3rd generation * age less than 18 years old and over 65 years old; * those who are on dispensary registration in a psychiatric institution at the place of residence with a diagnosis not related to icd-10 under the heading f20.0 "paranoid schizophrenia"; * having a disease duration of less than 1 year (from the moment of taking under dispensary supervision): * having severe and chronic somatic diseases; * having severe and chronic neurological diseases; * having comorbid narcological pathology; * not signed informed consent to conduct this study

Keywords: gwas
atrial fibrillation patients treated with catheter ablation

Conditions: Atrial Fibrillation; Atrial Fibrillation Recurrent

Summary: this is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.

the effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ecg monitoring within 1 week after radiofrequency ablation. a predictive model for atrial fibrillation recurrence after ablation will be established. based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.

Eligibility criteria:
inclusion criteria: * non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation * 18-80 years old * the anteroposterior diameter of the left atrium is less than 50mm via tte * patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists * patient consents to ablation treatment exclusion criteria: * intra-atrial thrombus detected by tee * hyperthyroidism * previous radiofrequency ablation for atrial fibrillation
hepatic artery stenosis and thrombosis after liver transplantation in children

Conditions: Hepatic Artery Thrombosis; Hepatic Artery Stenosis; Pediatric ALL; Liver Transplant; Complications

Summary: the goal of this observational study is to investigate the incidence, current management practices, and outcomes in pediatric patients with hac after liver transplantation. research question: * what are the overall incidence of hac and the effectiveness of all treatment strategies for hac after pediatric lt? * what are the current management practices in the experience of centers, anticoagulant therapy, screening protocol, and assessment criteria for hac after pediatric lt? the burden of participation is considered to be minimal, and limited to the questionnaires.


Eligibility criteria:
inclusion criteria: * liver transplantation between january 1st 2002 and january 1st 2022, diagnoses of hac after lt * the age of the patient is below 18 years at the time of diagnosis and intervention * the date of diagnosis of hac or intervention was before january 1st 2023. hac occurring after first or subsequent lts are included. exclusion criteria: n/a
screening for colorectal neoplasm in first degree relatives of the affected

Conditions: Colorectal Cancer Screening

Summary: to determine the prevalence of colorectal neoplasms in first degree relatives of those affected with sporadic colorectal cancer using colonoscopy as a screening tool. the prevalence will be compared to that of a defined matched cohort.

colorectal cancer is a second commonest tumor in hong kong and the second commonest cause of cancer related death. about 1 in 23 males will develop colorectal cancer in his life time. the disease tends to cluster in families. this may be a combination of factors including shared genes, shared environment or chance. known familial syndromes occur in only about 5% of cases. the majority is not well understood and labelled sporadic colorectal cancer. the screening strategy in families of subjects with colorectal cancer has not been defined. colonoscopy is among the most sensitive and specific screening tool for colorectal neoplasm. the current study determines the prevalence of adenomas among first degree relatives of patients diagnosed with colorectal cancer. to quantify risk in this cohort, a case control analysis is used. the prevalence of the cohort is compared to that of a control population. the control group consists of relatives of patients with normal colonoscopic findings during the same study period.

Eligibility criteria:
inclusion criteria: * first degree relatives (age \>40 and \<70) of individuals affected with sporadic colorectal cancer (those not associated with inflammatory bowel disease, familial adenomatous polyposis or hnpcc syndrome). exclusion criteria: * a family history compatible with that of hereditary non-polyposis colon cancer (hnpcc) based on the amsterdam criteria \[table 5\]. * known familial adenomatous polyposis (fap) syndrome * patients and relatives with known inflammatory bowel disease * relatives that have received colonoscopy examinations in the past 5 years \[details of colonoscopic examinations will be sought and information on colonic neoplasms recorded\]. those who have had barium enema examinations are eligible for trial inclusion as barium examinations often have low sensitivity and specificity for adenomas (around 70% respectively) * severe cardio-pulmonary or other medical co-morbidities that preclude safe colonoscopic examination

Keywords: colonoscopy first degree relatives
diagnostic performance of "emergency department assessment of chest pain score"

Conditions: Acute Chest Pain

Summary: this study aims to evaluate whether edacs performed during triage to assess patients with chest pain could improve the predictive validity of triage for an acute cardiovascular event.

chest pain is common reasons for presentation to the emergency department (ed).up to 6.3% of emergency department (ed) visits are related to chest pain. causes of chest pain range from musculoskeletal chest pain to potentially life-threatening emergencies as acute coronary syndrome(acs), aortic dissection or pulmonary embolism. therefore, accurate and fast risk stratification is paramount in the acute management, mainly to identify those patients with immediate risk of complications, as those with an acs. those patients are challenging to discriminate, as there is a variety of clinical manifestations. chest pain is considered to be an acute chest pain, described as pain, pressure, tightness, or burning as outlined in the guidelines chest pain equivalent symptoms may include dyspnea, left arm, and epigastric pain. triage helps recognize the urgency among patients. an accurate triage decision helps patients receive the emergency service in the most appropriate time. various triage systems have been developed and verified to assist healthcare providers to make accurate triage decisions. despite good levels of specificity, the available triage systems appear to have suboptimal sensitivities that cannot adequately prioritize patients with acute cardiovascular diseases. the emergency department assessment of chest pain score (edacs), through a standardized assessment of the patient's history and presenting symptoms only, provides good levels of sensitivity in stratifying time dependent acute cardiovascular diseases. the good discriminatory ability of edacs, combined with its easy clinical applicability, could be used to overcome some of the limitations of triage systems in assessing chest pain.

Eligibility criteria:
inclusion criteria: * patients \>18 years old who admitted to ed complaining of chest pain. * chest pain is considered to be an acute chest pain, described as pain, pressure, tightness, or burning as outlined in the guidelines. * chest pain equivalent symptoms may include dyspnea, epigastric pain, and pain in the left arm. exclusion criteria: * patients unable to complete the edacs * posttraumatic chest pain * patients who did not give consent to participate
effects of eed on zn absorption and retention in children from a mnp

Conditions: Environmental Enteric Dysfunction; Zinc Deficiency

Summary: the overall objective is to determine the impact of eed on total daily zinc absorption of young bangladeshi children (18-24 months of age) in an austere setting with high rates of diarrhea, stunting, and micro-nutrient deficiencies..

participating children are screened for eed using the lactulose:mannitol ratio test and assigned to one of two groups: +eed or -eed. after assignment to one of the two groups, proposed subjects will be randomized to one of four supplement groups: micronutrient powder (mnp) with 15 mg zn, mnp with 10 mg zn, mnp with 5 mg zn, and mnp with 0 mg zn. children will receive the supplement once with a meal on day 8 of the study. absorption of zinc from the supplement and from other non-supplemented meals will be determined using zinc stable isotope technology.

Eligibility criteria:
inclusion criteria: * absence of apparent health problems that would impair ability to consume regular diet, to tolerate zinc supplements, or to comply with demands of metabolic studies * length for age z (laz) score between -1.5 to -3.0 * hg ≥ 8 exclusion criteria: * outside age range * hb \< 8 * chronic illness * zinc supplement within past 2 weeks (including for treatment of diarrhea or mnp containing zinc) * severe stunting and/or severe acute malnutrition (sam): laz \<-3; whz \<-3 or muac \< 115 or edema

Keywords: environmental enteric dysfunction environmental enteropathy zinc absorption bangladesh toddlers zinc isotope
highcycle study: effect of high altitude on sleep disordered breathing in women related to their menstrual cycle phase

Conditions: Sleep-Disordered Breathing

Summary: prospective cohort study investigating the menstrual cycle phase (mcp) dependent sleep disordered breathing (sdb) in women travelling to 3600 m.


Eligibility criteria:
criteria: inclusion criteria: * healthy, non-smoking women, age 18-44 years, without any diseases and need of regular medication (including oral contraceptives). * bmi \>18 kg/m2 and \<30 kg/m2 * born, raised and currently living at altitudes \<1000 m * written informed consent * premenopausal, eumenorrheic cycle exclusion criteria: * other types of contraceptives (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others) * pregnancy or nursing * anaemic (haemoglobin concentration \<10g/dl) * any altitude trip \<4 weks before the study * allergy to acetazolamide and other sulfonamides

Keywords: periodic breathing hypoxia prevention acetazolamide women altitude
the correlation among nutrition, muscle strength, masticatory and swallow ability of inpatient elders

Conditions: Malnutrition; Moderate

Summary: the masticatory performance would affect the nutritional status of elderly people. the prevalence of undernutrition among elderly inpatients is %20-50%. previous related studies investigate the masticatory performance with special chewing gum and self-reported questionnaires. this study observes the correlation of masticatory muscles semg, nutritional status, and handgrip force among elderly inpatients.

in this cross-sectional study, we enrolled 120 seniors aged 65 and above who are newly admitted to the asian university hospital. within 24 hours they admitted to the hospital, we collected the mini nutritional assessment scores, surface electromyography data, handgrip strength, self-assessment swallowing ability score, and clinical objective data. we performed the statistics for independent t-test, pearson correlation analysis, and binary logistic regression with spss 23 software.

Eligibility criteria:
inclusion criteria: * new elderly inpatients aged 65 years or older who were able to communicate and were clearly conscious exclusion criteria: * elderly individuals who were diagnosed with gastrointestinal (gi) dysfunction, dysphagia, edentulism without rehabilitation with dentures, brain disease, stroke or cancer were excluded due to the possibility of dysphagia, cachexia or masticatory muscle palsy.

Keywords: the elder inpatient, nutritional assessment handgrip strength masticatory electromyography