Kornimate/medical-research-clean huggingface dataset:
evaluation of individuals with partial or finger amputation after silicone prosthesis use

Conditions: Amputation; Quality of Life; Psychosocial Adaptation; Silicone Prosthesis; Functionality

Summary: objective: this study aimed to evaluate the psychosocial adaptation, functional capacity, and quality of life of individuals who underwent partial hand or foot amputations after using silicone hand and foot prostheses. materials and methods: the study included 32 patients. demographic and clinical characteristics of the participants were recorded. participants were divided into two groups as silicone hand or foot prosthesis users. the visual analog scale (vas) was used to assess pain levels before and after prosthesis use, the trinity amputation and prosthesis experience scales (tapes) were applied to evaluate functional capacity, and the nottingham health profile (nhp) was used to assess quality of life.


Eligibility criteria:
inclusion criteria: * hand and foot amputation. * aged between 18 and 60 years * active employee * able to walk, co-operate, move actively with hands * who have been using prosthesis for at least 1 year and have good stump-socket compatibility, * literate individuals were determined on a voluntary basis. exclusion criteria: * multiple amputations * severe neurological or traumatic findings * individuals with severe deformity or posture disorder that may lead to loss of gait, balance or function. * with limitation of movement in the upper extremities
school-based treatment for early childhood anxiety

Conditions: Anxiety

Summary: this pilot will be used for academic research, in hopes of developing effective treatments for early childhood anxiety. the intervention is an adaptation of parent-child interaction therapy (pcit). pcit is an evidence-based intervention, rooted in attachment and social learning theory. in recent years, researchers have successfully adapted pcit to address anxiety in a clinical setting (pcit-calm). in this pilot study, we will be applying the pcit-calm intervention in the school setting, emphasizing teachers as a therapeutic agent of change. pcit is unique because the child's caregiver is trained on how to use therapeutic techniques, and then receives live coaching via a "bug in the ear" as they learn to implement the new skills. in this pilot study, both parents and teachers will be taught skills to create a therapeutic relationship and address anxiety. after these teaching sessions, the child's teacher will receive coaching in the classroom to implement the skills. the intervention will last approximately 12 weeks.


Eligibility criteria:
inclusion criteria: * scores in the at-risk or clinical range for anxiety on the basc-3 or cbcl (which will be filled out by a parent and teacher to determine eligibility) * child must be enrolled at the montessori school of denver where the intervention is being conducted. exclusion criteria: * none if other criteria are met. * comorbidity will not exclude a child, but if comorbidities are discovered for which there are other evidence-based treatments available, parents will be encouraged to seek additional resources.

Keywords: parent-child interaction therapy (pcit) calm protocol teacher-child interaction training (tcit)
efficacy of combining prophylactic curosurf with early nasal cpap in delivery room: the curpap study

Conditions: Respiratory Distress Syndrome, Newborn

Summary: the primary objective of this study is to compare two methods of post-delivery stabilization and subsequent early respiratory care for reducing the need for mv and related secondary complications, such as bpd, in premature babies at high risk of rds: 1. early stabilization on ncpap 2. intubation, prophylactic surfactant (curosurf®) administration shortly after delivery, and rapid extubation to ncpap. the data obtained from this comparison will be applied to test the hypothesis that preterm neonates at risk of rds who are treated with prophylactic surfactant + ncpap show less need for mv when compared to infants who receive ncpap alone.


Eligibility criteria:
inclusion criteria: * preterm neonates with a gestational age (ga) of 25+0 - 28+6 completed weeks. * inborn neonates. * in case of twins, both neonates will be included in the same treatment arm. * parental written informed consent for participation in the study obtained on admission into the hospital or prior to delivery. exclusion criteria: * evidence of severe birth asphyxia, that is an apgar score below 3 at 5 minutes of age. * need for endotracheal intubation for cardiopulmonary resuscitation or insufficient respiratory drive. * known genetic or chromosomal disorders. * delivered to mothers with ruptured membranes of more than 3 weeks duration. * potentially life-threatening conditions unrelated to immaturity. * participation in another clinical trial of any placebo, drug, biological, or device conducted under the provisions of a protocol.

Keywords: surfactant rds ncpap mechanical ventilation premature infants neonatal respiratory distress syndrome (nrds)
a study to assess the changes in pigmentation and safety of afamelanotide in patients with vitiligo on the face

Conditions: Vitiligo

Summary: the cuv104 study will assess the efficacy and safety of afamelanotide in patients with vitiligo on the face and body as a monotherapy in repigmentation.


Eligibility criteria:
inclusion criteria: * male and female patients with a confirmed diagnosis of vitiligo on the face and with t-vasi range 0.5-50% * stable face vitiligo with f-vasi of at least 0.1% * stable or slowly progressive vitiligo over a 3-month period * fitzpatrick skin types iv-vi * treatment with narrowband (nb)-uvb light 2-3 times per week during the last four weeks preceding the first implant for priming exclusion criteria: * patients with segmental vitiligo * fitzpatrick skin types i-iii * treatment with nb-uvb phototherapy in the last three months prior to phototherapy, excluding the sessions for priming in the four weeks prior to treatment. a 3-month washout period from phototherapy is necessary prior to priming. * previous topical treatment for vitiligo * allergy to afamelanotide or the polymer contained in the implant or to lignocaine/lidocaine or other local anaesthetic to be used during the administration of the implant * history of melanoma or lentigo maligna * any current skin disease that may interfere with the study evaluation * presence of severe hepatic disease or hepatic impairment * renal impairment * history of systemic or psychiatric disease judged to be clinically significant by the investigator and which may interfere with the study evaluation * female who is pregnant or lactating * female of child-bearing potential not using adequate contraceptive measures during the treatment phase and for a period of three months thereafter * sexually active man with a partner of child-bearing potential who is not using adequate contraceptive measures, as described above * participation in a clinical trial for an investigational agent within 30 days prior to the screening visit * use of any other prior and concomitant therapy which may interfere with the objective of the study * subjects assessed as not suitable for the study in the opinion of the investigator
pragmatic randomized controlled trial of pharmacopuncture therapy for adhesive capsulitis : a pilot study

Conditions: Adhesive Capsulitis

Summary: this is a 2-arm parallel pragmatic randomized controlled trial that will compare pharmacopuncture therapy with physical therapy for adhesive capsulitis.

participants who voluntarily signed informed consent form and eligible for the study were randomly assigned in a 1:1 ratio (25:25) for pharmacopuncture therapy and physical therapy group. participants of each group will receive twice a week for total 6 weeks of intervention. this is a pragmatic randomized controlled trial, so physicians will have medical decision making according to each participant's conditions.

Eligibility criteria:
inclusion criteria: * limitation of the shoulder movement (active or passive) * numeric rating scale (nrs) of neck pain is more than 5 * symptoms of adhesive capsulitis for more than 1 month * discrimination findings which can explain clinical symptoms on shoulder mri or ct * 19-69 years old * participants who agreed and wrote informed consents exclusion criteria: * case of being diagnosed with a specific serious disease that may cause shoulder pain(fracture, dislocation, etc.) * cause of pain due to soft tissue disease, not the spine(cancer, fibromyalgia, ra, goat, or etc.) other chronic diseases(stroke, mi, kidney disease, diabetic neuropathy, dimentia, epilepsy, or etc.) that may interfere with the interpretation of therapeutic effects or outcomes * participants taking steroid, immunosuppressant, psychotropic medication, or taking other drugs that may affect outcomes * inappropriate or unsafe pharmacopuncture therapy; hemorrhagic disease, taking anticoagulant drug, or severe diabetes patients who are likely to be infected * participants who took nsaids or pharmacopuncture, acupuncture, physical therapy within 1 week * pregnant, planning to get pregnant or lactating women * participants who had undergone shoulder surgery within 3 months * participants who had participated in other clinical trial within 1 month, had participated in other study within 6 months from the date of selection, or have plan for participation in other trial during follow up period of this trial * participants who can not write informed consent * participants who is difficult to participate in the trial according to investigator's decision
lakeshore examination of activity and disability exercise response study

Conditions: Multiple Sclerosis; Stroke

Summary: this study will examine the effectiveness of two types of group exercise classes on the health and functional status in inactive adults age 18-65 with neurological conditions including multiple sclerosis, stroke, and spinal cord injury (sci). participants will be randomly assigned to one of three groups; movement to music, adapted yoga, or a waitlist group who will complete a home-based exercise intervention of either movement to music or adapted yoga.


Eligibility criteria:
inclusion criteria: * diagnosed with stroke * ms - mild to moderate disability (patient determined disease steps score 0-6) * able to use arms or arms/legs for exercise * ambulatory or use manual wheelchair exclusion criteria: * cognitive impairment (mini-mental state exam score \< 24) * recent weight change (+/- 25 pounds in 1 year) * poorly controlled blood pressure * cardiovascular disease event within the past six months * severe pulmonary disease * renal failure * current tobacco user or quit within the last six months * current use of medications for psychosis * active pressure ulcers
concomitant cc and e2 versus cc alone in ovulation induction

Conditions: Infertility; Anovulation

Summary: the purpose of this study is to evaluate the effect of concomitant administration of estradiol during use of clomiphene citrate (cc) for induction of ovulation in infertile women.

women will be randomly divided into two groups; cc-e2 group and cc group. women in the cc-e2 group will receive cc (100 mg/day for 5 consecutive days from day 2 of cycle) and estradiol (2 mg/day for 5 consecutive days from day 2 of cycle). women in the cc group will receive cc (100 mg/day for 5 consecutive days from day 2 of cycle) and placebo mimic estradiol (for 5 consecutive days from day 2 of cycle). transvaginal sonography (tvs) scan will be performed regularly for monitoring of follicular growth (folliculometry); starting from day 10 of the stimulation cycle and repeated every 2-3 days. when there will be at least one follicle ≥ 18 mm in diameter, final oocyte maturation will be induced by intramuscular administration of 10000 iu of human chorionic gonadotropin (hcg) and timed intercourse will be advised. if there will be no follicle ≥ 12 mm by day 16 of the cycle, monitoring of follicular growth will be discontinued and the cycle will be presumed to be anovulatory. ovulation will be documented by tvs scan one week after triggering of oocyte maturation and will be confirmed by assessing the midluteal serum progesterone level. each woman will be subjected to ovarian stimulation for a maximum of 3 consecutive cycles except if she gets pregnant in the first or second cycle.

Eligibility criteria:
inclusion criteria: * infertile women with eugonadotrophic anovulation/oligoovulation. * unexplained infertility. exclusion criteria: * age \ 35 years. * body mass index (bmi) \ 25 kg/m2. * presence of any infertility factor other than anovulation/oligoovulation. * previous history of ovarian surgery or surgical removal of one ovary. * previous exposure to cytotoxic drugs or pelvic irradiation. * metabolic or hormonal abnormalities.

Keywords: clomiphene citrate estradiol endometrial thickness
chlorhexidine bathing effect on clostridium difficile rates

Conditions: Clostridium Difficile

Summary: clostridium difficile (c. diff.) infections, whether nosocomial or community borne, may present with profound diarrhea, especially in those patients receiving antibiotics. based on a preliminary review of hospital data, the investigators have found that these symptomatic c. diff infections occur with a relatively high incidence at delnor hospital. notwithstanding their high mortality, one recent study attributes a near quadrupling of hospitalization costs to c. diff infections. chlorhexidine baths have been shown in multiple randomized trials to help reduce the incidence of highly virulent pathogens and hospital acquired infections. further, several studies show a favorable effect of reducing the incidence of c. diff infections by using chlorhexidine baths on icu patients. far fewer studies, however, have focused on the effects of these baths on general medical/surgical wards. this investigation seeks to study the effect of the daily use of 2% chlorhexidine gluconate wipes in patients on the general medical/surgical wards who are exposed to antibiotics for a suspected or confirmed infection.


Eligibility criteria:
inclusion criteria: * prescription of antibiotics for suspected or confirmed infection. * admitted to the 2600 general/medical ward at delnor hospital. exclusion criteria: * antibiotics only for surgical prophylaxis * not mentally capable * cannot provide consent in english * pregnant * documented chlorhexidine allergy * patient is a prisoner * health system employee

Keywords: chlorhexidine bathing
tdcs and motor training and motor deficit after stroke

Conditions: Stroke

Summary: this study investigated the combined effects of anodal tdcs and intensive motor training (mt) vs. sham stimulation with mt (control intervention) on grip strength, motor performance and functional use of the affected arm in population of chronic stroke patients.

a growing body of evidence are available regarding the effectiveness of anodal transcranial direct current stimulation (tdcs) in patients with chronic hand motor impairment as a stroke consequence. this study investigated the combined effects of anodal tdcs and intensive motor training (mt) vs. sham stimulation with mt (control intervention) on objective evaluation of fine and gross motor hand function using simulated activities of daily living (jebsen-taylor hand function test), grip strength, motor performance and functional use of the affected arm in this population of patients. patients with chronic hand motor deficits after stroke (\> 12 months) are randomly assigned to active stimulation or a control intervention arm in a double-blinded, sham-controlled, parallel design. each group received intensive mt for 45 min/day, 5 days/week, for 2 weeks, which was preceded by 20 minutes of 2 milliampere of anodal tdcs over the ipsilesional m1 vs. sham tdcs. outcome measures are tested at baseline (t0), and after the intervention day 1 (t1), after stimulation protocol completion day 10 (t2) and 30 days later (t3).

Eligibility criteria:
inclusion criteria: * diagnosis of stroke made by clinical features and documented by neuroimaging studies (ct or mri scans * stroke duration \> 12 months * severe hand deficit at stroke onset (medical research council grade \<2) and * subsequently recovered to the level moderate hand deficit with presence of hand movements evaluated by the fugl-meyer upper-extremity assessment (fma) of motor recovery after stroke between 28-50 points (max. 66 pts), * spasticity between 0-2 assessed on the modified ashworth scale exclusion criteria: * any clinically significant or unstable medical disorder, * diagnosis od major depression, * diagnosis odf substance or alcohol abuse or any neurological disorder other than stroke, including neglect, aphasia, hemianopsia and serious cognitive impairment (mini-mental state examination \< 24). * any contraindications to tdcs, including histories of seizure, cerebral aneurysm, and prior surgery involving metallic implants

Keywords: tdcs motor recovery
prefrontal transcranial random noise stimulation in patients with depression

Conditions: Depression

Summary: transcranial random noise stimulation is used to stimulate the prefrontal cortices in patients with depression. it's a placebo-controlled two-arm study.

transcranial random noise stimulation (trns) is a non-invasive electric stimulation technique of the brain which was shown to be superior effective in contrast to other electric stimulation such as transcranial direct current stimulation (tdcs). these studies investigated mainly healthy controls and specific tasks. only one case report is available for depression. here we stimulate patients with depression with trns in a placebo-controlled two-arm design. stimulation will be done as add-on to standard therapy. electrodes will be applied over both dorsolateral prefrontal cortices which are standard target points of tdcs and also transcranial magnetic stimulation in depression.

Eligibility criteria:
inclusion criteria: * episode of depression (unipolar or bipolar) ( icd-10) * female or male between 18 and 70 years old * skills to participate in all study procedures * 18 or more points in the hamilton rating scale or depression * written informed consent exclusion criteria: * clinically relevant unstable internal or neurological comorbidity * evidence of significant brain malformations or neoplasm, head injury * cerebral vascular events * neurodegenerative disorders affecting the brain or prior brain surgery * metal objects in and around body that can not be removed * pregnancy * alcohol or drug abuse * eczema on the head * heart pacemaker * high dose tranquillizers

Keywords: depression; trns
entecavir for patients with decompensated hepatitis b virus (hbv)-related cirrhosis

Conditions: Hepatitis B Virus; Decompensated Cirrhosis

Summary: the aim of this study is to evaluate the effect of entecavir for patients with decompensated hbv-related cirrhosis.

chronic hepatitis b is one of the most widespread viral infections worldwide, potentially leading to liver cirrhosis and hepatocellular carcinoma. previous studies demonstrated that patients with active viral replication, defined as the presence of detectable serum hbv-dna or hbeag, were at increased risk of developing progressive liver disease or death.the prognosis of decompensated cirrhosis resulting from chronic hepatitis b virus infection is poor. anti-viral therapy in decompensated hbv-related cirrhosis has been recommended by the american association for the study of liver diseases. however, no high quality research on the effectiveness of anti-viral therapy in decompensated cirrhosis has been performed. entecavir is a new nucleotide analogue, which has been proved effective in suppressing viral replication and decreasing the necroinflammatory response, was recommended as a first-line medication in aasld guideline. our purpose was to evaluate the effect of entecavir for patients with decompensated hbv-related cirrhosis. the main outcomes were liver function, hbv-dna, disease progression, hepatocellular carcinoma, child-pugh score and the survival.

Eligibility criteria:
inclusion criteria: 1. over 16 years of age; 2. evidence of active viral replication was documented by a positive test for hbv-dna in serum; 3. liver cirrhosis was proven by ultrasound or ct; 4. decompensated cirrhosis was evidenced by a child-pugh score ≥ 7; 5. patients had decompensation signs such as jaundice, ascites, variceal bleeding, hepatic encephalopathy exclusion criteria: 1. evidence of hepatocellular carcinoma (suspicious foci on hepatic ultrasonography at screening or a rising serum level of alpha-fetoprotein) 2. a serum alanine aminotransferase level more than 10 times the upper limit of normal 3. coinfection with hepatitis c or d virus or human immunodeficiency virus 4. other types of cirrhosis 5. a history of anti-viral therapy 6. a total bilirubin level higher than 170 mmol/l 7. a history of malignant tumors

Keywords: entecavir cirrhosis anti-viral therapy
efficacy of peppermint and green tea in malodor

Conditions: Bad Breath

Summary: background: herbal remedies can have the role of prevention and control of bad breath since in the previous studies, therapeutic and antibacterial effect of green tea and peppermint had been proven .we studied and compared the effects of green tea and peppermint mouthwashes on halitosis. materials and methods: this single-blind clinical trial study with cross over design total of 88 volunteer dental students who complained bad breath and had organoleptic score (\>= 2) and higher average test scores were enrolled. the students were divided randomly into two groups green tea - peppermint were assigned. organoleptic test in the baseline, on the 7 day, 14 and 21 measured after rinsing the mouthwashes .as well as the satisfaction of both plants on the last day was considered. data analysis was performed using tests; wilcoxon signed rank test, mann whithney u, gee (generalized estimating equation -ordinal logistic regression).


Eligibility criteria:
inclusion criteria: organoleptic number equal to or higher 2 no foods (garlic and onion) 48 hours before organoleptic test exclusion criteria: systemic disease * use of antibiotics during study use of other mouthwash during study

Keywords: mouth wash , green tea , peppermint , bad breath