Kornimate/medical-research-clean huggingface dataset:
long-term use of takepron capsules on the prevention of recurrence of gastric/duodenal ulcer in patients receiving low-dose aspirin

Conditions: Gastric or Duodenal Ulcers

Summary: the purpose of this study is to investigate the safety and efficacy of long-term administration of lansoprazole (takepron) for up to 12 months in the routine clinical setting in patients receiving low-dose aspirin

this is a special survey on long-term use (for up to 12 months) of lansoprazole (takepron) to determine the incidence of adverse drug reactions in the routine clinical setting in patients receiving low-dose aspirin. the usual adult dosage is 15 mg of lansoprazole administered orally once daily.

Eligibility criteria:
inclusion criteria: * (1) patients with a history of gastric or duodenal ulcers (2) patients requiring long-term use of low-dose aspirin (81-324 mg once daily) as prophylaxis for thromboembolism (3) patients taking low-dose oral aspirin (81-324 mg once daily) at the start of administration of lansoprazole (including patients who start low-dose aspirin on the same day as the start of administration of lansoprazole) exclusion criteria: * (1) patients with gastric or duodenal ulcer (in the active \[a1, a2\] or healing \[h1, h2\] stage if assessed endoscopically) at the start of administration of lansoprazole (2) patients with active upper gastrointestinal hemorrhage at the start of administration of lansoprazole (3) patients with contraindications for lansoprazole

Keywords: pharmacological therapy
percutaneous peritoneal dialysis catheter insertion (predict)

Conditions: End-stage Kidney Disease

Summary: peritoneal dialysis (pd) is the most frequent modality of home dialysis for patients with kidney failure. most pd catheters are placed using a laparoscopic technique. this approach requires the availability of a qualified surgeon, time in the operating theater and general anaesthesia for the patient. thus, the laparoscopic technique is less suitable for patients with severe heart failure or multimorbidity where general anaesthesia is not possible. pd catheters can also be inserted using a percutaneous strategy using a modified seldinger technique. this strategy can be performed bedside under local anaesthesia, by the nephrologist, radiologist, a surgeon, physician assistant or qualified nurse. the availability of the percutaneous implantation strategy of a pd catheter in a nephrology center may accomodate more patients to receive a pd catheter insertion, including those who have a contraindication to general anaesthesia or need urgent pd. the predict project aims to increase knowledge and competencies on percutaneous pd catheter insertions by training centers for this technique. by establisching a prospective registry, the outcomes of percutaneously inserted pd catheters, both in experienced and newly trained centers, will be assessed.

the population of the predict study are adult patients requiring a peritoneal dialysis catheter insertion. decision for percutaneous strategy of catheter insertion (versus surgical catheter insertion) is made by the treating physician. the inclusion criteria for the prospective predict registry are age \> 18 years and percutaneous pd catheter insertion between 1 march 2023 and 1 march 1 2026 in participating centers. patients can be included 4 weeks before until 12 weeks after pd catheter insertion. the exclusion criteria are the inability to give informed consent and a life expectancy of less than 3 months. demographic and clinical data will be collected for all included patients.

Eligibility criteria:
inclusion criteria: * age \> 18 years * percutaneous pd catheter insertion between march 1st 2023 and march 1st 2026 patients can be included 4 weeks before until 12 weeks after pd catheter insertion exclusion criteria: * inability to provide informed consent * life expectancy \< 3 months
extended follow-up after islet transplantation in t1d

Conditions: Type 1 Diabetes (T1D); Islet Transplantation

Summary: the purpose of this study is to provide patients who have received at least one islet transplant as a previous participant in a clinical islet transplantation consortium (cit) clinical trial with maintenance immunosuppressive medications and to collect information about the safety of the medications and islet function.

after islet-cell transplantation in the cit studies\*, each subject receives maintenance immunosuppressive medications. the purpose of this protocol is to collect additional follow-up for safety and efficacy from cit subjects with graft function after their completion in their cit parent study. it is expected that most subjects will retain measurable islet function and, in the islet-alone studies, continue to receive immunosuppressive medications at the time of completing their cit parent study. \*cit parent studies: cit02 (nct00464555), cit03 (nct00434850), cit04 (nct00468403), cit05 (nct00468442), cit06 (nct00468117), and cit07 (nct00434811)

Eligibility criteria:
inclusion criteria: * subjects who have received an islet transplant during participation in the following clinical islet transplantation (cit) parent studies: cit02 (nct00464555), cit03 (nct00434850), cit04 (nct00468403), cit05 (nct00468442), cit06 (nct00468117), and cit07 (nct00434811) * a functioning pancreatic islet graft (e.g., absence of graft failure as defined in parent study) requiring immunosuppression * willingness of participants to continue to use an approved method of contraception during and 4 months after study participation * ability to provide written informed consent * resident of the united states of america * documentation of the existence or lack of health insurance coverage and whether immunosuppressants are covered. exclusion criteria: * for female subjects-positive pregnancy test, presently breast-feeding, or unwillingness to use effective contraceptive measures for the duration of the study and 4 months after discontinuation * for male subjects-intent to procreate during the duration of the study or within 4 months after discontinuation or unwillingness to use effective measures of contraception. oral contraceptives, norplant®, depo-provera®, and barrier devices with spermicide are acceptable contraceptive methods; condoms used alone are not acceptable. * received an islet transplant in a non-cit research study * any medical condition that, in the opinion of the investigator, will interfere with safe participation in the trial.

Keywords: islet allograft function c-peptide production maintenance immunosuppressive medications
impact of the safe childbirth checklist in luapula province of zambia province of zambia

Conditions: Maternal Death; Newborn Death

Summary: this study would like to determine if the introduction of the safe childbirth checklist and associated mentorship can improve the adherence of skilled birth attendants (sbas) to the essential practices of childbirth delivery.

this study will use a pre-post study design to measure health worker adherence to the essential practices for delivery care outlined in the safe childbirth checklist (scc). the intervention, including the introduction of the scc and mentorship visits to support uptake, will be tested in four purposively selected health facilities in nchelenge district, luapula province of zambia. since the essential delivery care practices outlined in the scc are evidence-based practices broadly accepted to support positive clinical outcomes for mothers and infants, this evaluation will focus on adherence to the checklist rather than on patient outcomes. data will be collected through observations of skilled birth attendants assisting with childbirth delivery before the start of the intervention and again at 3 months and 6 months post-intervention. a health worker questionnaire will be administered at the time that the scc is introduced and six months later to gather their perspectives on incorporating the scc into clinical practice in zambia.

Eligibility criteria:
inclusion criteria: * for facility observations, all consecutive deliveries will be observed. if a pregnant woman or health worker declines to participate in the consent process, no observations will be recorded. exclusion criteria: -

Keywords: childbirth delivery
effectiveness of dipeptide n (2)-l-alanyl-l-glutamine in trauma icu patients: pilot, prospective, randomized and double blind study.

Conditions: Trauma ICU Patients

Summary: recent reports suggest that most beneficial results of glutamine have been obtained with the parenteral administration of high doses of glutamine (0.35 g/kg/d) and in some special group of patients, such as traumatic patients. nevertheless total parenteral nutrition is not often used in critically ill patients. the endovenous administration of the the dipeptide n(2)-l-alanyl-l-glutamine in trauma icu patients can reduce the number of infections, icu length of stay and mortality. this benefit can be achieved independently the type of nutrition (enteral or parenteral nutrition), being a pharmaconutrient.

objective: to evaluate the efficacy of the endovenous administration endovenous glutamine to reduce the number of infectious complications, mortality and icu length of stay in trauma icu patients. to achieve this objective we have designed this pilot study to obtain the necessary data to design a bigger trial in the future. other objectives include: * to evaluate the efficacy of glutamine in different patients regarding their severity: patients with an injury severity score\> 25 and patients with lower plasma levels of glutamine. * to registry the possible adverse events of the endovenous administration of glutamine.

Eligibility criteria:
inclusion criteria: * moderate to severe trauma, as defined by an injury severity score (iss) \> 10 points were included in the study. * traumatic patients who required enteral or parenteral nutrition during the first 48 hours after hospital admission * written informed consent exclusion criteria: * patients whose life expectancy was less than 5 days, * who were allergic to glutamine, * patients included in any other trial * cirrhotic patients (child c) * chronic renal failure

Keywords: glutamine, trauma patients, infections, mortality
detection of colorectal adenoma by optical enhancement technology vs. high-definition colonoscopy

Conditions: Colonic Polyps

Summary: optical enhancement technology might be superior to the conventional hd-wl in detecting colorectal adenomas

colorectal cancer is the third most common cancer in the world.colonoscopy is the gold standard screening test for colorectal cancer.there are also emerging data to support that screening by colonoscopy reduces both the incidence and mortality of colorectal cancer.however,colonoscopy could still miss colorectal adenomas and even cancer.the miss rate for colonic adenomas was reported to be ranging from 15 to 32% in tandem colonoscopy studies.the reasons for the miss rate may be technical(insufficient during excessively fast instrument withdrawal),but may also be the imaging method.smaller lesions ,particularly flat ones ,may be missed as a result of their subtle appearance and limited contrast in relation to the surrounding mucosa. some image-enhanced modules were developed with an aim to improve colorectal polyp or adenoma detection.the widely available modules is the narrow band imaging(nbi).however,most studies failed to demonstrate any superiority of nbi system over white light colonoscopy in detecting colonic polyps.nbi provides dimmer images of the colonic mucosa ,which may limit its performance on polyp and adenoma detection. like nbi,oe technology is image-enhanced module,providing a more intense look at the vascular pattern morphology.besides,oe technology provides an much brighter image compared to nbi.this may possibly increase polyp detection by enhancing visibility of the colonic mucosa with brighter image.the current study aims to tested whether oe technology would improve adenoma detection when compared with high-definition colonoscopy.

Eligibility criteria:
inclusion criteria: * patients were selected if they presented for diagnostic colonoscopy for a variety of indications(eg positive fecal occult blood test, abdominal pain, diarrhoea,post-polypectomy surveillance). exclusion criteria: * patients with prior resection of the proximal colon, advanced colonic cancer, inflammatory bowel disease, or polyposis syndrome. * the cecum could not be intubated. * inadequate bowel preparation (aronchick bowel preparation scale score poor or inadequate). * biopsies were not available. * unable to provide informed consent.

Keywords: adenoma detection rate optical enhancement technonogy colonoscopy
intraoperative small-dose esketamine infusion for pain control in burn patients

Conditions: Burns

Summary: this study aim to determine whether a small-dose esketamine infusion can be used for pain control in severe burn patients, and thereby reduce the total intra-operative opioid requirement. secondary objectives are to determine whether this low-dose esketamine infusion will increase the stability of circulation.


Eligibility criteria:
inclusion criteria: * all intubated adult burn patients( age\>18 ), presenting to the operating room; * burn area\> 30%. exclusion criteria: * allergy to esketamine or benzodiazepines * esketamine or ketamine use in the preceding 24 hours * increased intracranial pressure * increased intraocular pressure * porphyria * thyroid disorders * seizures * acute myocardial ischemia * children (patients under age 18), prisoners, pregnant or breastfeeding women, patients with psychosis, patients with developmental delay, and any condition which, in the opinion of the investigator, would prevent full participation in this study or would interfere with the evaluation of the trial endpoints.
the therapeutic effects of barkley's parenting management program for taiwanese school-aged children with attention deficit/hyperactivity disorder (adhd)

Conditions: Attention Deficit/Hyperactivity Disorder

Summary: the purpose of this study is to explore the therapeutic effects of barkley's parenting management program for taiwanese school-aged children with adhd. the investigators hypothesized that barkley's parenting management program might empower the parents' competence to manage their school-aged children's adhd-related disturbing behaviors as its previously-proven effects for parents and their preschool-aged children with adhd.

participants will be recruited from the child psychiatric clinics of ntuh-yunlin branch and will include 30 school children with adhd, their parents and teachers. the kiddie-schedule for affective disorders and schizophrenia-epidemiology version will be adopted to confirm the diagnosis of adhd. the child participants will received assessments of the conner's continuous performance test, and the wechsler intelligence scale for children-4th edition. we use adhd symptoms, children't wellbeing, parent-child relationship, parent's competence and parenting stress as the outcome indices of therapeutic effects.research instruments employed include cbcl, snap-iv, parental bonding instrument, the family adaptability and cohesion evaluation scale, chinese health questionnaire, parenting stress index, short form, multidimensional student's life satisfaction scale and nowicki-strickland locus of control scale for children.

Eligibility criteria:
inclusion criteria: * parents of 7-12 year-old aged children with adhd and overall normal intelligence exclusion criteria: * parents of children with comorbid autism spectrum disorders

Keywords: parenting management program adhd
effect of micronutrients and life skills education on the health and nutrition of adolescent and young women in pakistan

Conditions: Adolescents; Anemia; Pregnancy; Empowerment

Summary: the primary aims of this study are: 1) to evaluate the impact of supplementation with multiple micronutrients (mmn) from preconception and life skills education among women 15-18.9 years of age at enrolment on the prevalence of anemia in a population setting; and 2) to evaluate the impact of supplementation with mmn from preconception and life skills education among young women 15-24 years of age on the rate of low birth weight (lbw) in a population setting. infants born to mothers enrolled in the study will be followed for 1 year. this study aims to enrol 25,400 non-pregnant young women in matiari district. this sample size is anticipated to equate to 1456 births. participants will be randomized by cluster to receive either mmn supplements and life skills education or the standard of care at enrolment. clusters have been defined based on health facility catchment areas. mmn supplements will be provided twice weekly during the preconception period, once daily during the pregnancy period, and once daily until 6 months after giving birth during the postpartum period; and a package of life skills education materials will be provided bi-monthly during the preconception period. in addition to the primary outcomes, measurements will include micronutrient status, anthropometrics, birth outcomes, dietary intake and feeding practices, adherence, and indices of empowerment.


Eligibility criteria:
inclusion criteria: * minimum age at enrolment: 15 years * maximum age at enrolment: 23 years * any marital status * intend to comply with study intervention and follow up exclusion criteria: * women participating in other nutrition trials * women who intend to leave the study area * women who are already pregnant

Keywords: preconception supplementation multiple micronutrients low birth weight
effect of intensive lipid lowering treatment compared to moderate lipid lowering treatment on carotid intima-media thickness (cimt)

Conditions: ST-segment Elevation Myocardial Infarction; Subclinical Carotid Atherosclerosis

Summary: the aim of this study was to measure the effect of moderate and intensive lipid-lowering treatment with rosuvastatin on the carotid intima-media thickness (cimt) as a surrogate marker of cardiovascular risk.

the aim of this study was to measure the effect of moderate (5mg) and intensive (40mg) lipid-lowering treatment with rosuvastatin on the carotid intima-media thickness as a surrogate marker of cardiovascular risk and to obtain whether cimt correlated with the plaque components in coronary arteries evaluated with intravascular ultrasound virtual histology (ivus-vh).

Eligibility criteria:
inclusion criteria: 1. stemi, 2. no prior treatment with statins and 3. a non significant lesion in one of the two non-culprit coronary arteries. - exclusion criteria: 1. age below 18 or above 81 years, 2. unconscious patients, 3. serum creatinine \> 176μmol/l, 4. total-cholesterol \> 7.0 mmol/l, 5. hypothyroidism ((tsh \> 1.5 x uln (upper limit of normal)), 6. current liver disease (alat \> 2 x uln), 7. unexplained creatine kinase \> 3 x uln, 8. alcohol or drug abuse within the last five years, 9. prior myopathy or serious hypersensitivity reaction caused by statins, 10. women with childbearing potential who were not using chemical or mechanical contraception, 11. pregnant or breastfeeding women, 12. history of malignancy unless a disease-free period of more than five years was present, 13. patients with abnormal lung function test (lft), 14. participation in another investigational drug study less than four weeks before enrolment in the present study, 15. treatment with cyclosporine or fibrates. -

Keywords: cimt ivus-vh coronary artery disease
feasibility study of a software application for patients hospitalized after suicidal ideation or suicide attempts

Conditions: Suicide, Attempted; Suicidal Ideation

Summary: the primary objective of this feasibility study is to assess the feasibility, and usability of a software application to deliver targeted interactive exercises to patients recently hospitalized for suicidal ideation or suicide attempts.


Eligibility criteria:
inclusion criteria: * english speaking male or female patients, 18-70 years * patients who have attempted suicide and voluntarily admitted themselves to an inpatient psychiatric unit or have clinically significant suicidal ideation and intent to harm themselves and are still on the inpatient psychiatric unit. * understand written and spoken english * own an iphone with ios 11 or higher, or android with os 8.1 or higher * willing and able to complete enrollment procedures * able to understand the nature of the study and provide written informed consent * able and willing to provide at least two verifiable contacts for emergency or tracking purposes. exclusion criteria: * patients with active psychosis * patients who are acutely intoxicated at the time of enrollment * currently enrolled in other treatment studies for the symptoms and behaviors targeted * patients who are cognitively impaired * patients who, in the judgment of the investigator, would have an unfavorable risk/benefit (e.g. critically ill patients) profile with respect to the software application that delivers interactive exercises.
periodized resistance training for persistent non-specific low back pain

Conditions: Low Back Pain

Summary: in this study the feasibility is investigated of a 16-week supervised heavy resistance training program with weekly undulating periodization for individuals with persistent non-specific low-back pain.


Eligibility criteria:
inclusion criteria: * persistent non-specific low back pain with a duration \>3 months * average low back pain intensity last two weeks \>= 4 on numerical pain rating scale (0-10 scale) * no experience with heavy resistance training. exclusion criteria: * previous surgery of the low back * radiculopathy * structural spinal changes and/or specific spinal conditions that limit function (spinal stenosis, ankylosing spondylitis, spondylolisthesis/spondylolysis, protrusion, structural scoliosis) * autoimmune and systemic inflammatory diseases * cardiovascular disease * neurological diseases * severe osteoporosis.

Keywords: exercise therapy resistance training