Kornimate/medical-research-clean huggingface dataset:
experimental therapeutics in essential tremor using transcranial direct current stimulation

Conditions: Essential Tremor

Summary: the purpose of this study is to determine whether transcranial direct current stimulation (tdcs) delivered over the motor cortex or the cerebellum can improve essential tremor and to identify the cerebral mechanisms involved in these potential effects.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years and \< 50 years * important essential tremor (bilateral postural and/or action tremor since more than one year) * normal physical and neurological examination, except for essential tremor * insufficient efficiency of usual essential tremor's treatment * no treatment altering the cortical excitability * agreement to use a medically acceptable method of contraception throughout the study for female of childbearing potential exclusion criteria: * cervical tremor * current neurological or psychiatric illness other than essential tremor * individual who is on medication which is known to lower seizure threshold * previous history of seizure(s), malaise or current active epilepsy * contraindication for mri or tms study * pregnancy, breast feeding women and women who are of childbearing age and not practicing adequate birth control * individual who have mms ≤ 24/30 or patients legally protected or inability to provide an informed consent * simultaneous participation in another clinical trial * patients who are not enrolled at social security

Keywords: essential tremor primary motor cortex cerebellum transcranial direct current stimulation electrophysiology
implanted loop recorders for detection and management of arrhythmia with bruton tyrosine kinase inhibitors

Conditions: Atrial Fibrillation; Supraventricular Arrhythmia; Ventricular Arrhythmias and Cardiac Arrest; Chronic Lymphocytic Leukemia; Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Summary: this study will enroll patients initiating bruton tyrosine kinase (btk) inhibitors without history of documented arrhythmia while on therapy using the medtronic linq-2 insertable cardiac monitor (ilr). the incidence of new onset atrial fibrillation (af) and other arrhythmia will be determined. actions taken in response to device detected arrhythmia will be recorded.

this single arm, prospective non-blinded study will enroll 50 patients initiating treatment with btk inhibitors (ibrutinib, acalabrutinib, zanubrutinib or pirtobrutinib) without documented arrhythmia prior to starting btk inhibitor therapy, without contraindications to an implanted loop recorder (ilr). they will be offered the option of monitoring arrhythmias using the medtronic linq-2 insertable cardiac monitor (ilr). monitoring data will be collected prospectively until the patient withdraws consent, the device is removed, or up to 60 months. investigators hope to obtain information on arrhythmia incidence including af, ventricular arrhythmia (va), and actions taken in response to awareness of such episodes.

Eligibility criteria:
inclusion criteria: * \>18yo * willing to sign and date consent form, * willing to be remotely monitored * initiating btk inhibitor for approved condition (i.e. cll, waldenstrom's, etc) * willing to have medtronic cardiac monitor inserted to allow at minimum 24 hours continuous monitoring prior to initiating btk inhibitor exclusion criteria: * documented af/va in past 12 months * cerebral vascular accident (cva) or transient ischemic attack (tia) in past year * has current implanted pulse generator, defibrillator, pacemaker, or resynchronization device * heart surgery within past 90 days * myocardial infarction within past 90 days * patient is taking an anti-arrhythmic or anticoagulant * has concomitant condition that precludes safe participation in study (substance abuse, etc) * enrollment in separate study that could confound results of this study

Keywords: bruton tyrosine kinase (btk) chronic lymphocytic leukemia (cll) mantle cell lymphoma waldenstrom's macroglobulinemia atrial fibrillation (af) ventricular arrhythmia (va) sudden cardiac death ibrutinib acalabrutinib zanubrutinib pirtobrutinib implanted loop recorder/implanted cardiac monitor (ilr)
effect of oncothermia on improvement of quality of life in unresectable pancreatic cancer patients

Conditions: Cancer, Pancreas

Summary: patients with pancreatic cancer often suffer from pain. because of such a pain, their quality of life have seriously deteriorated. there have been a few studies that showed an effect for pain control by hyperthermia (heating the patient's body). however, there are several limitations in conventional hyperthermia. in this study, the investigators tried to show the effect of "oncothermia" which is more selective to malignant tissue than conventional hyperthermia for pain control, increasing quality of life, and anti-tumor treatment.


Eligibility criteria:
inclusion criteria: * inoperable or recurred pancreatic ductal adenocarcinoma * after the each cycle of chemotherapy, the disease status was "stable disease" exclusion criteria: * person who has an experience of hyperthermia treatment * person who has a difficulty of sensing heat * person who has a skin graft or breast reconstruction surgery * person who has a cardiac pacemaker or an implanted metal * pregnant or breast feeding women * person with uncontrolled infection, diabetes, hypertension, ischemic heart disease, myocardial infarct within 6 months * person who was treated with unproved drugs within 6 months * person who have a serious disease which can affect the person's safety * person who do not consent to the study

Keywords: pancreatic cancer quality of life pain
a safety and efficacy study of corneal injection for endothelial dysfunction using human corneal endothelial cell therapy in subjects with corneal edema secondary to endothelial dysfunction

Conditions: Corneal Edema

Summary: the purpose of this study is to assess the safety of a fixed dose of human corneal endothelial cells when administered with varying concentrations of rho kinase inhibitor (y-27632) in patients with corneal edema secondary to endothelial dysfunction.


Eligibility criteria:
key inclusion criteria: 1. must have given written informed consent (signed and dated by subject or legal guardian), and any authorizations required by local law and be able to comply with all study requirements 2. clinical diagnosis of corneal edema secondary to endothelial dysfunction 3. best corrected visual acuity (bcva) no worse than 20/800 etdrs (1.6 logmar) or better than 20/63 (0.5 logmar) in the study eye key exclusion criteria: 1. keratoconus or other conditions of corneal thinning/ectasia 2. progressive stromal or anterior corneal dystrophies 3. pre-operative corneal epithelial, sub-epithelial or stromal staining, scarring or other opacity that is paracentral/central and visually significant, but not suspected to be secondary to corneal endothelial disease with the potential to improve from treatment with hcec-1 4. prior ophthalmic surgery including cataract surgery except as noted above in inclusion criterion #4, corneal transplantation, glaucoma (migs, iridectomy, trabeculectomy, valve), or vitreo-retinal surgery, aphakia, anterior chamber-iol or iris claw iol, multifocal iol. 5. relative afferent pupillary defect (rapd) in the study eye 6. uncontrolled glaucoma or an iop greater than 24 mmhg that is not controlled with topical beta blockers alone at the time of the screening visit.
effects and safety of epidural pdrn vs. placebo

Conditions: Spinal Stenosis Lumbar

Summary: this is a single-center, randomized, double-blind clinical study to assess the clinical application and outcomes with epidural pdrn versus normal saline injection in patients with spinal stenosis.

patients who are already planning to receive an transforaminal epidural block from their clinician will be approached by study members on the day of their injection. if enrolled, the patients will be contacted every 2 weeks for 4 weeks to determine the severity of pain and degree of pain relief from the injection.

Eligibility criteria:
inclusion criteria: * 1. adults aged between 19-80 years old * 2. radiological confirmation of spinal stenosis on mri * 3. neurogenic claudication greater thanvas 4 of due to spinal stenosis * 4. follow-up possible during 3 months the clinical trial exclusion criteria: * not able to comply fully with the protocol, including treatment, follow-up or study procedures * pregnant or feeding women * alcohol/drug abuse * anticoagulant medication
multimodal neurodiagnostic imaging of traumatic brain injury and post-traumatic stress disorder

Conditions: Traumatic Brain Injury; Post-Traumatic Stress Disorder

Summary: the purpose of this study is to determine whether the brains of persons with and without traumatic brain injury differ in a meaningful way when advanced technology images of the brain are taken using three newer technologies that visualize the brain using a combination of external/internal magnetic fields and radioactive tracers (molecules that emit detectable particles). the hope is that the results of this study will validate tools (help prove that diagnostic tools actually detect disease) for the diagnosis and treatment of traumatic brain injuries (tbi).

'normal' appearing brain is often not normal when imaged with advanced neuroimaging techniques. it has been advocated that a battery of neurological assessments (including meg) be developed to assess mild traumatic brain injury (tbi) and studies have shown that somatosensory evoked fields in severe tbi can serve as a measure of cortical function in comatosed tbi patients. functional neuroimaging techniques such as pet and fmri may reveal abnormalities in areas considered 'normal' on traditional mri. most significantly, advanced functional neuroimaging may enable customized neurorehabilitation planning with more efficient use of resources. the study aim is to compare healthy brains, civilian tbi brains, and combat-related tbi to identify correlations between abnormal imaging parameters with neurorehabilitation potential utilizing advanced neurological imaging. the study hypothesis states severity of traumatic brain injury (tbi) and post-traumatic stress disorders (ptsd) can be detected and quantified using a multimodal battery of neurodiagnostic imaging techniques (meg, pet/ct, 3 tesla-mri w/ dti and fmri) and rehabilitation potential can be predicted in the post acute phase.

Eligibility criteria:
inclusion criteria: 1. at least 18 years of age and non-active duty 2. either: 1. normal (no history of head injury) -or- 2. tbi (injury since jan. 1, 2002) exclusion criteria: 1. incapable of informed consent or absence of legally authorized representative. 2. incarcerated (or subject to court supervision). 3. known allergy to protocol contrast/imaging agent (or pregnant and unable to receive agent) 4. mri incompatible (i.e. implant, metal, \> 300 lbs, severe claustrophobia)

Keywords: traumatic brain injury tbi military imaging meg pet/ct mri fmri dti sanic veteran
lifestyle control of postprandial hyperglycemia

Conditions: Type 2 Diabetes

Summary: large spikes in blood glucose experienced after meals in people with type 2 diabetes are known to damage blood vessels. low carbohydrate high fat diets and exercise can improve blood glucose control in people with type 2 diabetes but it is unclear how these two strategies interact to affect blood vessel function and inflammation. we will examine how following a short-term low carbohydrate high fat diet (4 days) with or without post-meal walking impacts markers of blood vessel function and inflammation. we will also examine how a single low carbohydrate high fat meal, with or without post-meal walking, impacts blood glucose control and blood vessel function. findings will help determine the best lifestyle approach for improving cardiovascular health in type 2 diabetes.


Eligibility criteria:
inclusion criteria: * diagnosed with type 2 diabetes (at least 6 months ago) * aged 40-75 * engaging in 2 or less moderate-to-vigorous exercise bouts per week in the last 3 months * ability to understand and communicate in english to interact with the personal trainer exclusion criteria: * diagnosed coronary artery disease * any contraindications to exercise (e.g., musculoskeletal injury) * prior history of cardio- or cerebrovascular disease or myocardial infarction * hypertension that is not controlled by medication (systolic blood pressure (bp) \>160 mmhg and/or diastolic bp \>99 mmhg) * change in diabetes medications in the previous 6 months * diagnosed with peripheral neuropathy * taking exogenous insulin
citicoline for alcohol dependence

Conditions: Alcohol Dependence

Summary: the purpose of this study is to determine if citicoline, as an add-on therapy, will help reduce alcohol use in outpatients with alcohol dependence.

a total of 62 outpatients with alcohol dependence will be enrolled in a 12-week, randomized, placebo-controlled trial. participants will be randomized to receive either placebo or citicoline. throughout the study, participants will be asked about their alcohol use and any withdrawal or craving symptoms. depressive symptoms will be measured as well. cognition and memory will be measured as well with a neurocognitive battery. blood will be drawn at study start and week 12 to measure liver enzyme levels. appointments will be weekly for the entire study. participants will have a physician follow-up at every study appointment.

Eligibility criteria:
inclusion criteria: * men and women age 18-75 years old with diagnosis of alcohol dependence * average alcohol use of at least 28 drinks per week and at least 7 heavy drinking days (defined as 4 or more drinks/day for women, 5 or more drinks/day for men) in the past 28 days * no alcohol use within 72 hours of randomization (maximum abstinence 7 days) * ciwa-ar (withdrawal scale) score less than or equal to 8 at randomization (consistent with minimal or no withdrawal symptoms and medication probably not needed) exclusion criteria: * vulnerable populations including individuals with intellectual disability or dementia, prison or jail inmates, pregnant or nursing women, or women of childbearing age who will not use acceptable forms of birth control * history of arrhythmias * myocardial infarction or coronary artery bypass graft surgery in the past 6 months * active angina or blood pressure \>170/105 * high risk for suicide (defined as suicide attempt in past 6 months, or current suicidal ideation with plan and intent) * high risk of violence toward others (defined as assault in past 6 months, or violent thoughts with evidence of plan and intent) * intensive outpatient treatment for substance abuse (aa, na meetings or weekly therapy/counseling for substance use for at least 28 days prior to randomization will be allowed) * dependence (not just abuse) on substances other than alcohol or nicotine * history of delirium tremens or other sever alcohol withdrawal symptoms, history of cirrhosis or ast or alt \>3 times normal, or other unstable medical condition (e.g. uncontrolled diabetes) * history of bipolar disorder or schizophrenia * current major depressive episode (past episodes and current milder depressive symptoms allowed) or other psychiatric disorder that should be a major focus of treatment

Keywords: alcohol dependence alcohol abuse
improving medication adherence in hypertensive patients

Conditions: Hypertension

Summary: the study team is proposing a single arm intervention to test the effect of an electronic intervention on medication use among individuals with a prescription for hypertension/high blood pressure. the investigator proposes that technology like text messaging, email, web applications and mobile apps with proven, nurse intervention scripts, will lead to significant, cost-effective improvements in hypertension medication use.

the intervention will incorporate a scalable electronic intervention using email/web apps and short message service (sms)/mobile web apps. the study team will examine the participants' responses to the electronic encounters in the technology-only intervention throughout the 3-month study timeframe.

Eligibility criteria:
inclusion criteria: * enrolled in the primary care clinic for the past 6 months * new or existing prescription for hypertension * poorly controlled mean systolic blood pressure (sbp) in the last 12 months (\>140/90 hg) exclusion criteria: * hospitalized for a stroke, myocardial infarction, coronary artery revascularization in the past 3 months, * diagnosis of metastatic cancer; * active diagnosis of psychosis or dementia documented in medical record; * does not have access to the appropriate technology required * is not willing to use said device to receive notifications for the study; * does not live independently (assisted living or nursing home residents) or otherwise institutionalized or receiving home health care * severely impaired hearing, vision or speech (unless technological aides allow them full functionality) * planning to leave the area or change primary care clinics prior to the anticipated end of participation; * unable to read and understand spoken english * participation in another cardiovascular disease (cvd) study * another household member enrolled in study; * arm size \> 50cm
the effects of high-intensity and moderate-intensity exercise on polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome; Exercise; Cerebrovascular Circulation

Summary: this study will investigate the impact of high- and moderate-intensity exercise on the cardiometabolic and brain health of women with polycystic ovary syndrome (pcos). the aim is to measure and compare normal, healthy women without pcos, to those with the condition. all participants will undergo a blood test. the investigators will then assess the participants cardiovascular fitness by means of a maximal exercise test and measure body composition through height, weight, and hip-to-waist ratio. participants will undergo an mri, where the investigators will assess the participants brain structure and how the brain responds to a number of tests. the investigators will also conduct some tests that will assess the participants cognition, such as iq, memory etc. the investigators will measure the blood vessels leading to the brain and the blood flow through them to measure how much blood the brain receives when rested, using ultrasound. the investigators will use a number of tests to look at brain function, measure the responses to these tests, and compare them between the normal, healthy women and those with pcos. this will show if women with pcos have a similar brain function when rested and when their brains are tested to those without the condition. the investigators will use exercise as an intervention, where the aim will be to investigate whether women with pcos respond similarly to those without the condition to both high-intensity and moderate-intensity exercise. the tests of brain function will be repeated following the exercise, and see if both normal, healthy women and those with pcos have a similar response to the brain function tests. all tests and measures will be compared between the pcos group, and the healthy control group to establish any potential differences or similarities as a result of the condition.


Eligibility criteria:
inclusion criteria: * polycystic ovary syndrome as diagnosed by any recognised criteria. * inactive (less than 40 mins of structured exercise per week). exclusion criteria: * pregnant or breastfeeding. * congenital adrenal hyperplasia, cushing's syndrome, thyroid disease, hyperprolactinaemia and androgen secreting tumours. * known history of cardiovascular disease. * contraindications to mri (fitted with ferromagnetic devices).

Keywords: pcos polycystic ovary syndrome exercise high-intensity interval training moderate-intensity steady state cerebrovascular
a pilot study of a strategy and computer-based intervention to enhance daily cognitive functioning after stroke

Conditions: Stroke

Summary: this is an initial pilot study to test feasibility, participant engagement and satisfaction, and clinical and neurobiological target engagement of a behavioral treatment called "ascend" that combines computer-based cognitive training and coaching of cognitive strategies to improve daily cognitive functioning in individuals with stroke.


Eligibility criteria:
inclusion criteria: * history of first-time stroke, minimum of 6 months prior to enrollment * english speaking * ability to comprehend sufficiently to participate in the treatment. * subjective or objective evidence of mild cognitive impairment * willingness to participate in full study duration * has computer that meets specification for the training program software. * physically able to operate a computer keyboard and mouse. * not concurrently receiving other cognitive rehabilitation services * cognitively able to perform basic self-care activities (e.g., dressing, grooming, eating). exclusion criteria: * history of neurologic disease other than stroke * history of severe mental illness or substance use disorder, or current major depressive episode. * history of dementia or dependence in basic self-care activities due to cognitive deficits * contraindications to mri
sleep-related breathing disorders in cardiological outpatients

Conditions: Sleep Apnea Syndromes

Summary: the purpose of this study is to determine the prevalence of sleep-related breathing disorders (srbd) in clinically stable cardiologic outpatients of a german university clinic by means of polygraphy. furthermore, the practicability of the underlying diagnostic process in clinical application is assessed as well as the sensitivity and specificity of polygraphy as compared to the reference standard of polysomnography. another aim is to determine the individual cardiovascular risk profile by pulse wave analysis and risk classification according to european society of hypertension (esh) and european society of cardiology (esc), "esh/esc risk".


Eligibility criteria:
inclusion criteria: * age ≥18 years * present chronic cardiovascular disease (incl. but not limited to: ischemic heart disease, arterial hypertension, heart failure, atrial fibrillation) * current clinically stable state (incl. patients after a cardiovascular-related, emergency hospital admission and subsequent recompensation towards the end of their hospital stay exclusion criteria: * age \<18 years * acute life-threatening disease (incl. but not limited to:instable angina pectoris, acute bronchial asthma, heart failure new york heart association (nyha) stage iv, myocardial infarction, exacerbated chronic obstructive pulmonary disease (copd), malignant disease requiring treatment) * pregnancy and/or lactation * any medical, psychological or other condition impairing the patient's ability to provide informed consent
predictors of pain relief from mindfulness-based stress reduction (mbsr) in multiple forms of chronic pain patients

Conditions: Chronic Pain Syndrome

Summary: the overall objective of this study is to better understand how mindfulness-based stress reduction (mbsr) is the most helpful in terms of management of chronic pain symptoms. the studies hypothesis is that an interventional response phenotyping study (light phenotyping) can identify individuals with different underlying mechanisms for their pain who thus respond differentially to evidence-based interventions for chronic pain disorders.

participants enrolled in this study will receive 8 weeks of mbsr therapy and complete surveys at various time points pre-treatment - post treatment.

Eligibility criteria:
inclusion criteria for mbsr study * ages 18+ * any form of self-reported chronic pain (except cancer related pain) exclusion criteria for mbsr study * unable to speak and write english * visual or hearing difficulties that would preclude participation * chronic pain from cancer.

Keywords: chronic pain rheumatoid arthritis fibromyalgia neuropathy neuralgia pain