Kornimate/medical-research-clean huggingface dataset:
direct oral challenges in private practice setting to delabeling children with beta-lactam allergy

Conditions: Allergy

Summary: the purpose of this study is to demonstrate the feasibility of direct oral challenge performed in private practice setting for children with suspected benign delayed allergy to beta-lactams. the results of this study could help establish recommendations for conducting direct oral challenge in primary care settings to delabeling children with benign delayed reactions to beta-lactams.

approximately 10% of children are labeled as allergic to beta-lactams (bl). consequently, they receive alternative antibiotics with a broader spectrum but lower efficacy, leading to increased infectious morbidity and mortality, a higher risk of colonization with antibiotic-resistant bacteria, and elevated healthcare costs. however, true bl allergy is only confirmed in 5-10% of cases. therefore, an essential challenge is to promptly identify non-allergic children to prevent unnecessary medical restrictions. the most common reactions are delayed and benign. current guidelines recommend evaluating these reactions through direct oral challenge (doc) without prior allergological assessment, as traditional diagnostic methods, particularly skin tests, have poor sensitivity in this context. however, the optimal setting for conducting these tests remains debated, particularly regarding whether they can be initiated in hospital settings or private medical practices. to date, over 8,300 docs have been performed in children, predominantly in hospital-based consultations. these tests have demonstrated a favorable safety profile, with positive doc reactions often being of the same nature and less severe than the initial reported reaction. while many physicians perform docs in private practice, data on their use in pediatric populations remain scarce. the primary objective of this study is to assess the feasibility of docs conducted in private medical practices for children with suspected benign delayed allergy to bl

Eligibility criteria:
inclusion criteria: * population: children's age between 0 and 17 years * child who has undergone a direct oral challenge in a private medical practice and a follow-up consultation within 7 to 14 days for suspected delayed allergy to amoxicillin +/- clavulanate or cefpodoxime or cefixime with the following characteristics: * delayed reaction (onset \> 1 hour after treatment start), * mild reaction (isolated urticaria or maculopapular exanthema), * absence of warning signs suggestive of a severe cutaneous adverse reaction (erythroderma, presence of bullae, vesicles, pustules, target lesions, involvement of oral, genital, or ocular mucosa, facial edema, general condition impairment, organ failure, duration \> 7 days). exclusion criteria: * informed children or holders of parental authority objecting to the use of patient data in the study.

Keywords: beta-lactams allerg allergology direct oral challenge
multiple ascending dose study of prx002 in patients with parkinson's disease

Conditions: Parkinson's Disease

Summary: this multiple ascending dose study is to determine safety, tolerability, pharmacokinetics and immunogenicity of prx002 in approximately 60 patients with parkinson's disease.


Eligibility criteria:
inclusion criteria: * idiopathic parkinson's disease, hoehn and yahr 1-3 * body weight range of ≥ 45kg/99 lbs to ≤ 110 kg/242 lbs * female subjects must be surgically sterile or post-menopausal or if of child-bearing potential must use contraception * male subjects and their partners of childbearing potential must use contraception exclusion criteria: * significant cardiac history * abnormal mri * significant laboratory abnormalities
the influence of artificial intelligence (ai )assisted polyp detection (discovery system) on visual gaze patterns during real-time colonoscopy

Conditions: Colonic Neoplasms

Summary: in this study, the investigators aim to assess the influence of a computer-aided detection (cade) system on the visual gaze patterns of endoscopists in order to further understand the effect of ai during real-time colonoscopy.


Eligibility criteria:
inclusion criteria of patients: * referred for diagnostic, screening or surveillance colonoscopy exclusion criteria of patients: * therapeutic procedure * boston bowel prep score (bbps) score of \<6
kidney disease and pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: evaluation of the prevalence of kidney disease, hemodynamic predictors and long-term renal outcome in patients with invasively diagnosed pulmonary hypertension.

this study aims to determine the prevalence of kidney disease, hemodynamic predictors and long-term renal outcome of in-hospital patients with invasively diagnosed pulmonary hypertension at the department of pulmonology, university hospital giessen and marburg, giessen, germany between 1999 and 2016.

Eligibility criteria:
inclusion criteria: * older than 18 years * subjects with invasively diagnosed pulmonary hypertension at rest and available renal function and spot urine data at day of right heart catheterization between march 1999 and december 2016 at the department of pulmonology, university hospital giessen and marburg, giessen, germany exclusion criteria: * subjects with estimated gfr \<15ml/min/1.73m2 or prior dialysis * pre-existing acute kidney injury * non-end stage renal disease with extracorporeal or peritoneal ultrafiltration due to diuretic-resistant fluid overload * primary kidney disease requiring active immunosuppression * autosomal dominant polycystic kidney disease * if subjects are pregnant * if subjects are recipients of solid-organ transplants * subjects with pulmonary hypertension with unclear/multifactorial mechanisms (who group 5 pulmonary hypertension)
epidemiological insights into the formation, progression, and rupture of intracranial aneurysms: a retrospective, multi-center hospital-based study in china

Conditions: Intracranial Aneurysm; Subarachnoid Hemorrhage, Aneurysmal; Cerebral Aneurysm; Brain Aneurysm

Summary: this is a retrospective, hospital-based and multi-center study aiming at investigating the potential exposures associated with the formation, progression, and rupture of intracranial aneurysms in chinese population.

a striking conflict exists between the fatal rupture of intracranial aneurysms (ia) and the passive approach to detecting ia through cerebrovascular examinations. this is attributed to a limited understanding of risk factors for ia incidence and the resulting lack of cost-effective ia screening. this study aims to gain epidemiological insights into the exposures associated with the risk of ia incidence, including formation, progression, and rupture in the chinese population. it integrates multi-modal data based on large-scale electronic medical records from high-volume stroke centers across china to investigate potential associations between various exposures and ia incidence. patients with anonymous and unique ids were screened for the presence of ia by formal readings from digital subtraction angiography (dsa), cranial computed tomography angiography (cta), or magnetic resonance angiography (mra) conducted by two radiologists, which were then confirmed by two treating neurosurgeons using the raw images. using natural language processing in conjunction with medical records and multi-modal data, patient exposures were extracted and assumed to be absent if no documentation was found across the databases. through a series of retrospective analyses, we aim to identify the exposures associated with ia incidence as much as possible to gather valuable insights for future prospective research.

Eligibility criteria:
inclusion criteria: 1. ia diagnosis (ruptured or unruptured) or exclusion by digital subtractive angiography (dsa) or by cranial computed tomography angiography (cta) / magnetic resonance angiography (mra); 2. aged ≥ 18 and ≤ 18 years old; 3. with complete demographic data including age and sex; 4. with medical record archiving officially. exclusion criteria: 1. missing data of age, sex or hypertensive status; 2. age \ 80 years; 3. pregnancy; 4. with a history of intracranial arteriovenous malformation, moyamoya, polycystic kidney disease, ehlers-danlos syndrome, gronblad-strandberg syndrome, or marfan syndrome; 5. suspicion for dissecting or mycotic aneurysms or aneurysm-like lesions that were indistinguishable from the infundibulum, fenestration, dilation, or atherosclerotic remodeling on structural imaging scans.

Keywords: intracranial aneurysm clinical epidemiology exposures
cardiac stroke volume at rest and during different exercise intensities

Conditions: Cardiac Function

Summary: the main aim of the present investigation is to study cardiac function in different exercise intensities in healthy human subjects. two techniques will be used: cardiac ultrasound-derived stroke volume measurements and body impedance measurements. 20 healthy men (n=10) and women (n=10) aged 18-45 years will be investigated at rest and during exercise. all study procedures are non-invasive.


Eligibility criteria:
inclusion criteria: * age 18-45 * bmi 18-30 * resting blood pressure \< 140/90 mmhg * participation in regular exercise exclusion criteria: * acute illness * pregnancy * pace maker * artificial joint * history of a cardiac event * insulin or medically treated diabetes * any chronic disease or condition that could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results * abundant use of alcohol * use of narcotics * smoking of tobacco or consuming snuff tobacco * diagnosed depressive or bipolar disorder * abnormalities in resting ecg (revised by the study physician)
pathological classification of pulmonary nodules in images using deep learning

Conditions: Lung Cancer; Artificial Intelligence

Summary: this study aimed to develop a deep-learning model to automatically classify pulmonary nodules based on white-light images and to evaluate the model performance. besides, suitable operation could be chosen with the help of this model, which could shorten the time of surgery.

all white-light photographs of pulmonary nodules from phones of pathologically confirmed adenocarcinoma in situ (ais), minimally invasive adenocarcinoma (mia) and invasive adenocarcinoma (iac) were retrospectively collected from consecutive patients who underwent surgery between june 30, 2020 and september 15, 2021 at guangdong provincial people's hospital.finally, a total of 1037 white-light images from 973 individuals were included in the study. the entire dataset was divided into training and test datasets, which were mutually exclusive, using random sampling. of these, 830 images were used as the training dataset and 104 images from were used as the test dataset. the cnn model was used in classifying images, namely, resnet-50. for the cnn model, pretrained model with the imagenet dataset were adopted using transfer learning. after constructing the cnn models using the training dataset, the performance of the models was evaluated using the test dataset and the prospective validation dataset.

Eligibility criteria:
inclusion criteria: 1. male or female，18 years and older. 2. patients haven't undergone any therapy. 3. the pulmonary nodules were confirmed ais, mia or iac. 4. the sizes of pulmonary nodules were less than 3cm. 5. the images were jpg format. exclusion criteria: 1. suffering from other tumor disease before or at the same time. 2. images with poor quality or low resolution that precluded proper classification.

Keywords: lung cancer pathologic prediction deep learning
safety and efficacy study in acute ischaemic stroke

Conditions: Stroke

Summary: a phase ii study to evaluate the safety and efficacy of five dose levels of study drug in acute ischaemic stroke

an open label, dose escalation study where patients with acute ischaemic stroke will receive a single intravenous dose of study drug. there will be five dose levels with groups of 10 patients in each. escalation to higher doses will occur following review of safety data from the previous dose.

Eligibility criteria:
summary of inclusion criteria: 1. onset of new neurological signs of stroke within 3 to 9 hours of the time to initiation of treatment 2. aged 18 and above 3. provide consent 4. cerebral ct scan to show findings of early ischaemic changes consistent with the clinical diagnosis and an aspect score of between 5 and 10 inclusive. 5. nihss score greater than 5 or less than or equal to 20. summary of exclusion criteria: 1. coma 2. stroke with unknown time of onset 3. minor stroke symptoms and sings (\<6 points on the nihss) which are rapidly improving by the time of randomisation. 4. major stroke symptoms and signs (\>20 on the nihss) 5. history of stroke in previous 6 weeks 6. history of brain tumours 7. ct scan results in an aspect score of \<5 8. haemorrhagic risk 9. abnormal laboratory values 10. positive urine pregnancy test, lactation or parturition within previous 30 days. 11. weight \>135 kg 12. uncontrolled hypertension. 13. raised blood glucose 14. history of or current serious illness 15. participation in another clinical trial within 4 weeks of drug administration -

Keywords: acute ischaemic stroke
effects of soft tissue mobilization at different muscle lengths

Conditions: Muscle, Ligament and Fascia Disorders; Instrument Assisted Soft Tissue Mobilization; Range of Motion; Pain

Summary: the purpose of this study will be to compare the effects of instrument assisted soft tissue mobilization at different muscle lengths on pain pressure thresholds and measures of flexibility.

instrument assisted soft tissue mobilization is a widely used manual therapy technique, which aims at reducing pain and improving range of motion. evidence regarding acute responses to instrument assisted soft tissue mobilization at different muscle lengths is lacking. therefore, the purpose of our study was to conduct a cross-over trial and compare the acute effects of instrument assisted soft tissue mobilization at short and long muscle lengths of the calf muscles on pain pressure thresholds and measures of flexibility.

Eligibility criteria:
inclusion criteria: * without previous lower limb injuries in the last year * healthy individuals * students exclusion criteria: * patients with acute lower limb disorders e.g. open wounds, hematoma, trauma * general hypermobility: beighton score \>4.
the effect of sihogayonggolmoryeo-tang on the anxiety of hwa-byung

Conditions: Hwa-byung

Summary: in this randomized, double blinded, placebo-control trial, the investigators planned to give sihogayonggolmoryeo-tang extract or controlled medication on the anxiety of hwa-byung.


Eligibility criteria:
inclusion criteria: * male or female aged 20-65 * subjects who meet structured interview criteria for hwa-byung diagnosis * subjects who have axiety (more than 17 score in hama) exclusion criteria: * duration of illness less than 6 months * current or past history of delusions, hallucination * past history of at least one manic episode, hypomanic episode, or mixed episode * current or past history of alcohol abuse or alcohol dependence history * taking substances(e.g. steroids) which might affect symptoms * medical conditions(e.g. hyperthyroidism, hypothyroidism, heart disease) that might affect symptoms * current with hepatoma, hepatic cirrhosis, chronic renal failure, congestive heart failure * pregnancy, lactation, women not using medically accepted means of birth control * considered not apt to carry out clinical trial

Keywords: hwa-byung sihogayonggolmoryeo-tang anxiety
accuracy of peripheral pulse oximetry versus arterial co-oximeter in children with cyanotic heart disease

Conditions: Cyanotic Heart Disease

Summary: peripheral pulse oximetry allows continuous non-invasive measurement of arterial oxygen saturation, but the gold standard for arterial oxygen saturation is co-oximeter which requires an arterial blood sample. the purpose of this research study is to determine the accuracy of a pulse oximeter with a standard sensor (masimo lncs sensor) versus with the study sensors, namely masimo blue sensor and nellcor max-i sensors and compared against co-oximetry. currently available peripheral oximeters (standard) are inaccurate at low oxygen saturation noted in children with cyanotic heart disease. hence therapeutic interventions (including surgery and cardiac catheterizations) based solely on peripheral oximetry can be delayed and or inadequate. by doing this study the investigators will be able to establish correct limits of peripheral pulse oximeter when using the standard and the study sensors.

peripheral pulse oximetry allows continuous non-invasive measurement of arterial oxygen saturation, but the gold standard for arterial oxygen saturation is co-oximeter which requires an arterial blood sample. the purpose of this research study is to determine the accuracy of a pulse oximeter with a standard sensor (masimo lncs sensor) versus with the study sensors, namely masimo blue sensor and nellcor max-i sensors and compared against co-oximetry. currently available peripheral oximeters (standard) are inaccurate at low oxygen saturation noted in children with cyanotic heart disease. hence therapeutic interventions (including surgery and cardiac catheterizations) based solely on peripheral oximetry can be delayed and or inadequate. by doing this study we will be able to establish correct limits of peripheral pulse oximeter when using the standard and the study sensors. the investigator hopes to learn the limits of accuracy of currently available and used pulse oximeters. in children with cyanotic heart disease the "blue sensor" has been found in small studies to be more accurate compared to the "standard" pulse oximeter. this study is important as it will provide information as to which pulse oximeter should be routinely used in children with cyanotic heart disease and to assess which spo2 even with blue sensor is borderline and therefore the physician will know to obtain arterial blood sample for co-oximeter prior to planning important procedures based on a saturation reading.

Eligibility criteria:
inclusion criteria: 1. children from lpch undergoing cardiac catheterization or heart surgery in sumc or lpch respectively 2. peripheral arterial saturation less than or equal to 90% at time of enrollment 3. weigh between 3-20 kg 4. less than or equal to 10 years of age exclusion criteria: 1. lack of consent 2. greater than 10 years of age 3. less than 3 kg or more than 20 kg in weight 4. peripheral arterial saturation greater than 90% at time of enrollment 5. lack of arterial access
prevention of chyle-leak after major pancreatic surgery

Conditions: Lymph Leakage; Chyle Into Mesentery; Extravasation; Pancreatic Cancer; Complication of Surgical Procedure

Summary: chyle is lymphatic fluid present in the wall of the intestine. it flows trough lymphatic vessels to cisterna chyli and to venous circulation carrying lymphatic fluid, long-chain triglyceride fatty acids and proteins, fatty soluble vitamins and electrolytes. lymphatic vessels are at risk of damage in pancreatic surgery and especially when there is vein/artery resection and reconstruction at the same time. chyle leak can be seen in post-operative patients when there is milky substance coming out of the surgical drains and drain fluids triglyceride level is high (\>1,5 mmol/l). patients with chyle leak are at risk of dehydration, malnutrition, sepsis and prolonged stay at the hospital. usually treatment of chyle leak is with drains and no-fat diet up to 14 days after surgery. sometimes combined with somatostatine-analogue-treatment. in this study investigators are randomizing patients with major pancreatic surgery in to two groups. intervention group will start no-fat diet, including mct-oil, right after surgery up to 2 weeks. and control group will start the diet if chyle-leak is seen. end goal is to reduce chyle-leaks in post-operative patients and analyze if it has an effect on patients prognosis.

patient who come for pancreatic surgery and vein resection/reconstruction will be randomized before surgery in two groups. intervention group will start the no-fat diet right after surgery, with mct-oil supplement. diet will be continued up to 14 days after surgery. the control group will start the diet if chyle leak is diagnosed. criteria of chyle leak in this study is appearance of milky-coloured fluid from the surgical drains in post-operative day 3 and drain fluids triglyceride levels must be high (\>1,5 mmol/l). after enough patients have been recruited in the study, patient records are then analyzed to see if the no-fat diet has any effect on incidence of chyle-leak.

Eligibility criteria:
inclusion criteria: * need for a pancreatic resection with vessel resection/reconstruction exclusion criteria: * no pancreatic and vessel resection needed * patients do not want to join the study
safety and pk study of mp-424 to treat chronic hepatitis c

Conditions: Chronic Hepatitis C

Summary: the purpose of this study is to assess the safety, pharmacokinetics and hcv(hepatitis c virus) rna (ribonucleic acid) kinetics after administration of mp-424 to patients with chronic hepatitis c.


Eligibility criteria:
inclusion criteria: * patients diagnosed with genotype 1b chronic hepatitis c * patients naive to the concomitant medications with interferon exclusion criteria: * patients diagnosed with decompensated cirrhosis * patients diagnosed with positive hbs(hepatitis b virus surface) antigen in the test

Keywords: chronic hepatitis c protease inhibitor