Kornimate/medical-research-clean huggingface dataset:
plethysmographic pulse-contour and pulse-wave-transit-times for haemodynamic evaluation in bleeding simulation

Conditions: Health, Subjective

Summary: the evaluation of haemodynamic changes is still challenging in clinically relevant situations (e.g. in bleeding, septic and postoperative patients) with the conventional monitoring routinely used including heart rate and mean arterial pressure. if the arterial pressure drops and the heart increases, the haemodynamic state is already decompensated and a therapy is at risk being indicated too late. prior to decompensation - still in the state of compensated shock - it would be desirable to detect the shock already. the compensated shock is characterized by an occult drop of cardiac output and a hypoperfusion of vital organs like e.g. the splanchnic region. due to these pathophysiological characteristics, a therapy would be indicated already in this stadium of shock progression. the available monitoring tools to detect compensated shock are on the one hand side invasive (intravascular catheter), cost-intensive (cost of the catheter systems), or need extensive training (echocardiography). consequently, the implementation of advanced haemodynamic monitoring is still low despite the high clinical relevance for the patients. it is the goal of this project to evaluate in healthy volunteers the routinely implemented technology of photo-plethysmography in its ability to detect haemodynamic changes by extended signal analysis of the pulse-contour and the pulse-wave-transit-times in relation to the gold-standard echocardiography. secondary goal of this study is to analyse the physiological and haemodynamic changes during progressive central hypovolaemia displayed by non-invasive or minimal-invasive monitoring devices and associate the changes to each other.


Eligibility criteria:
inclusion criteria: * offered patient information and written informed consent * existence of valid health insurance * male gender exclusion criteria: * patients aged less than 18 years or more than 40 years * inability of german language use * lacking willingness to save and hand out data within the study * evidence of a chronic disease (cardio-vascular, renal, pulmonary, neurological, metabolic, gastro-intestinal) * chronic medication * signs of a reduced cardiorespiratory capacity * signs of an acute illness * participation in a prospective intervention trial during the study period * anamnestic hints for syncope or disposition to hypotension * signs of arterial hypertension * signs of inguinal hernia * relevant pathologies in the baseline examination of the transthoracic echocardiography * for the bio-impedance measurements: heart defibrillator
guidance for elderly with cognitive disorders

Conditions: Mild Dementia

Summary: the purpose of the programme is to facilitate the anticipation of dementia both in elderly patients suffering from this disease and in their carers and to diminish care burden in order to improve quality of life and daily functioning.


Eligibility criteria:
inclusion criteria: * elderly (\> 70 years) with mild dementia in presence of a carer.
the effect of postoperative incentive spirometry on pulmonary function and pulmonary complications in bariatric surgery

Conditions: Obesity, Morbid; Complications of Bariatric Procedures; Pulmonary Atelectasis; Pneumonia

Summary: this study evaluates the omission of incentive spirometry use following bariatric surgery. half of participants will receive an incentive spirometer while the other half will not. oxygen saturation and pulmonary complications after surgery will be measured to examine the effectiveness of incentive spirometry.

incentive spirometry is speculated to improve pulmonary function in the postoperative period, though data to support this is lacking. patients undergoing bariatric surgery are at increased risk for pulmonary compromise as they are obese and undergoing foregut surgery. this study aims to examine the effect of incentive spirometry after bariatric surgery by performing a prospective randomized trial. subjects will be randomized to either receive an incentive spirometer or not. the primary outcome measure of oxygen saturation off of supplemental oxygen will be taken preoperatively and at 6,12, and 24 hours postoperatively. secondary outcome measures include rate of pulmonary complications, and time to wean off of supplemental oxygen.

Eligibility criteria:
inclusion criteria: * patients medically cleared to undergo bariatric surgery per the usual screening process exclusion criteria: * none

Keywords: bariatric surgery obesity, morbid incentive spirometry
efficacy and safety of insulin aspart in subjects with type 1 or type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: this trial is conducted in asia. the aim of this trial is to compare the efficacy of postprandial plasma glucose of two treatment regimens in chinese subjects.


Eligibility criteria:
inclusion criteria: * type 1 or 2 diabetes for at least 4 weeks * treatment with oral antidiabetic drugs (oads) and/or insulin for at least 4 weeks * hba1c: 7.5-13.5% * body mass index (bmi): 18-35 kg/m2 exclusion criteria: * treatment with either soluble human insulin or insulin nph three times daily within 3 months before trial participation * history of drug abuse or alcohol dependence
intravenous lidocaine in bariatric surgery.

Conditions: Morbid Obesity; Bariatric Surgery Candidate

Summary: although peroperative intravenous lidocaine has been shown to be useful in early recovery after colorectal surgery, its beneficial effect on the specific population of obese patients scheduled for bariatric surgery remained unknown. investigators hypothesized that peroperative intravenous lidocaine could decrease postoperative opioid consumption and improve postoperative recovery

this is a prospective, double-blind, placebo-controlled, monocentric study. we plan to recruit 180 obese adult patients scheduled for bariatric surgery in a the french university hospital of caen. exclusion: contra-indications for any aminoamide local anesthetic (allergy, severe hepatic disease) and for intravenous lidocaine (porphyria, atrioventricular conduction disturbances, uncontrolled seizure disease), long term opioid consumption, need for a post-operative follow-up in an intensive care unit, combined surgical procedure excepting cholecystectomy, pregnancy. patients will be randomly allocated to receive either a saline placebo or lidocaine continuous infusions during surgery. morphinic consumption will be assessed from the end of the procedure until the third day after surgery. secondary criteria will concern post-operative recovery, pain and postoperative nausea and vomiting, other medical and surgical complications, and toxicity. plasma lidocaine concentrations will be measured in patients who had received lidocaine in order to determine the safety and efficiency of our infusion protocol. our analysis will be a superiority one, alpha risk is 5% and beta risk is 20%, in intention to treat, with no intermediate analysis.

Eligibility criteria:
inclusion criteria: * scheduled bariatric surgery exclusion criteria: * any contra-indication for lidocaine administration * pregnancy * asa class 4 * psychiatric disorder * chronic opioid consumption

Keywords: bariatric surgery rehabilitation lidocaine
survey of the collective 16s rrna genes from bacterial populations from exercising and non-exercising participants

Conditions: Dental Caries

Summary: poor oral health can greatly impact quality of life and can also impact overall health. for instance, research suggests that poor oral health may be associated with systemic diseases such as diabetes, heart disease, and stroke. therefore, there is a need to investigate the causes of poor oral health. the idea that athletes may have a propensity for dental caries has been gaining traction. there have been recent reports of high levels of dental caries, dental erosion and periodontal diseases among elite soccer players compared to the general public and in athletes from a wide range of sports. however, to date, no studies have investigated the oral microbiome of athletes. many factors affect the development of dental caries, including host factors, diet, and the microorganisms present in the oral cavity. more than 700 types of bacterial species have been detected in the oral cavity, and some have been identified to play a significant role in the development of oral disease. streptococcus mutans is the main species involved in dental decay with various lactobacilli also involved in the disease process. treponema denticola, porphyromonas ginigivalis, and aggregatibacter actinomycetemcomitans are the main species involved in periodontal disease. it is not currently known if changes in the collective oral microbiome foster or impede the development of these pathogens. complex microbe-host interactions occur to allow for the progression of oral disease, with host nutrition and hygiene playing a significant role. endurance athletes widely consume a variety of sport drinks, gels, and energy bars for supplementation of electrolytes and carbohydrates. the consumption of these foods leads to ph drops in the oral cavity and may contribute to tooth erosion and demineralization. oral disease may also be exacerbated by the fluid and electrolyte deficit that impedes saliva flow during exercise. however, several studies have failed to demonstrate a clear link between sports drinks and an increased risk of dental caries among athletes. dental caries are caused by microorganisms in the oral cavity. these microbes may be affected by host factors or nutrition in the progression of oral disease. due to the documented prevalence of dental caries in athletes and the lack of clear connection between sports drinks and dental caries, the investigators propose to investigate any correlation that may exist between exercise and the oral microbiome.


Eligibility criteria:
inclusion criteria: * participants must be between the ages of 18-24 and must be willing and healthy enough to start a modest exercise program if they are chosen, at random, to do so. exclusion criteria: * pregnant women, minors, and people over the age of 24 are excluded from the study. * anyone with a heart condition or other health condition that is not safely able to initiate a modest exercise program are excluded from the study.
frenotomy of the labial frenulum in infants with breastfeeding difficulties

Conditions: Breastfeeding

Summary: upper lingual frenulum have been implicated as a cause for pain during breastfeeding and latch problems. the investigators hypothesize that performing frenotomy of the frenulum may improve breastfeeding. the investigators will include breastfeeding infants with pain or latch problems in whom the lingual frenulum had been treated but breastfeeding problems were not resolved. the investigators plan to study the effect of frenotomy of the upper lingual frenulum on maternal pain (using pain score by visual analog scale) and/or latch score.


Eligibility criteria:
inclusion criteria: * breastfeeding infants * maternal nipple pain * latching problems exclusion criteria: * oral cavity anomalies * breast anatomical anomalies * untreated tongue-tie in infant

Keywords: breastfeeding difficulties lingual frenulum labial frenulum frenotomy
a phase 1/2, dose-exploration study to evaluate the safety and efficacy of beam-301 in patients with glycogen storage disease type ia (gsdia)

Conditions: Glycogen Storage Disease Type Ia

Summary: this is a phase 1/2, multicenter, open-label, single-ascending-dose study to evaluate the safety, tolerability, and efficacy of beam-301 in adult patients with gsdia homozygous or compound heterozygous for the g6pc1 c.247c\>t (p.r83c) variant and to determine the optimal biological dose.


Eligibility criteria:
inclusion criteria: 1. males or females age ≥18 years of age at the time of consent. 2. diagnosis of gsdia and homozygous or compound heterozygous for the g6pc1 c.247c\>t (p.r83c) variant (confirmed by genetic testing). 3. history of at least 1 episode of hypoglycemia \<60 mg/dl within the 2 years prior to signing the icf. exclusion criteria: 1. liver transplant recipient/on waiting list for liver transplant or known history of liver cirrhosis. 2. presence of liver adenoma \>5 cm in size based on liver mri or liver ultrasound performed at screening or within 6 months prior to screening. 3. presence of liver adenoma \>3 cm and ≤5 cm with a documented annual growth rate of ≥0.5 cm per year. 4. have aspartate transaminase or alanine transaminase \>upper limit of normal (uln). 5. total bilirubin levels \>uln; if documented gilbert's syndrome, total bilirubin \>2 × uln. 6. previous treatment with any cell-, gene-, or viral vector-derived therapy hospitalization for management of hypoglycemia within 4 weeks prior to signing the icf. 7. have triglycerides \>1000 mg/dl or a history of pancreatitis or a history of acute pancreatitis within 5 years that does not have a known and corrected etiology (eg, cholecystectomy for gallstone pancreatitis).

Keywords: gsdia gsd1a
integrated diagnosis and treatment of ckd on outcomes

Conditions: Chronic Kidney Diseases; Hypertension; Hyperglycemia; Hyperlipidemias; Anemia; Chronic Kidney Disease-Mineral and Bone Disorder; Malnutrition

Summary: objective: to establish a study cohort and follow up of patients with ckd in our hospital, and evaluate the status of integrated ckd diagnosis and treatment according to guidelines in the real world, as well as the clinical prognosis of patients with different stratification. methods: by establishing a cohort of 1000 patients with ckd and conducting long-term follow-up, integrated diagnosis and treatment for ckd was performed, namely: regular monitoring, control of blood pressure, blood glucose, blood lipid, correction of anemia, minerals - bone metabolic abnormalities, malnutrition, acid and alkali, and electrolyte disorder, diet and exercise, such as the guidance of integrated management, non intrusive, observational studies, prospective cohort were analyzed retrospectively, describe the implementation of the integration of diagnosis and treatment, chronic kidney disease (ckd) stratified analysis and risk factor analysis were performed for cardiovascular disease and other main endpoint events, so as to objectively reflect the status of integrated treatment of ckd and provide data support for continuous quality improvement of ckd diagnosis and treatment and improvement of clinical prognosis of patients.


Eligibility criteria:
inclusion criteria: * ≥18 years old; * voluntarily signed informed consent; * patients who are estimated to develop ckd. exclusion criteria: * age \< 18 or ≥100 years; * unable to comply with the procedures stipulated in this study; * estimated follow-up time ≤6 months.
effectiveness of therapeutic exercise versus manual therapy in patients with chronic neck pain

Conditions: Chronic Neck Pain

Summary: it has been estimated that between 50% and 85% of the population will suffer neck pain along their life. chronic nonspecific neck pain is one of the main causes of disability in the population, it represents 25% of visits to physiotherapy, and it also has a high chance of chronification. the efficacy of combining manual therapy and therapeutic exercise for the treatment of this pathology has been demonstrated a lot of times. however, no conclusive studies have been found that compare the isolated application of both treatments, thus being an important focus of action and research. the main objective of the study is to check if the treatment with therapeutic exercise is better than manual therapy in the improvement of the disability in patients with chronic neck pain. a randomized, controlled, monocentric, parallel and single-blind clinical trial will be carried out. the simple will be obtained from the population over 18 years old with chronic neck pain of more than 12 weeks of evolution and will be those who meet the inclusion and exclusion criteria. the patients will be randomly divided into 2 intervention groups, in one of the groups will be applied a manual therapy session of about 30 minutes once a week for 4 weeks. in the other group it will be delivered and explained to the patients, a home therapeutic exercise program that will be carried out on alternate days for 4 weeks.


Eligibility criteria:
inclusion criteria: * nonspecific cervical pain of more than 12 weeks of evolution. * over 18 years. exclusion criteria: * oncological processes. * pregnancy. * infectious diseases. * degenerative diseases. * fibromyalgia. * previous spinal surgeries. * previous traumatic events. * hernias and/or cervical protrusions. * neurological processes. * current treatment for cervical pain. * neuropathic characteristics pain.
frequency of dysphonia in asthmatic patients

Conditions: Asthmatic Patients and Control Group

Summary: for many years, it is known that asthmatics have more often dysphonia. however, no study has so far analyzed the reality of dysphonia in asthmatic by making phoniatric tests. the etiology of dysphonia in asthmatic remains controversial. indeed, for a long time, inhaled corticosteroids have been considered as responsible for organic abnormalities of the vocal cords. we hypothesized that women with asthma have more often dysphonia, and that dysphonia is rather functional origin.


Eligibility criteria:
inclusion criteria: * women * aged between 18 to 65 years * patient who signed the informed consent. * affiliated with a social security system. patients with asthma (gina criteria) - persistent asthma with inhaled corticosteroids.
corneal and conjunctival sensitivity and staining study

Conditions: Myopia; Hyperopia

Summary: the primary objective of this study is to compare subjective symptoms and ocular health in a group of individuals who are currently wearing soft contact lenses on a daily wear basis, after a short period of no lens wear and during the time course when using differing care regimens.

the primary objective of this study is to compare subjective symptoms and ocular health in a group of individuals who are currently wearing soft contact lenses on a daily wear basis, after a short period of no lens wear and during the time course when using differing care regimens. observations will be made to monitor physiology.

Eligibility criteria:
inclusion criteria: an eligible participant is one who: * is between 17-45 years old and has full legal capacity to volunteer. * has read and signed an information consent letter, after having the opportunity to ask questions and receive acceptable answers. * is willing and able to follow instructions and maintain the appointment schedule. * does not experience any dryness related symptoms during lens wear (i.e. at least 12 hours of comfortable wearing time) * is correctable to a visual acuity of 6/7.5 (20/25) or better (each eye) with their habitual vision correction. * has normal binocular vision (no strabismus, no amblyopia). * has clear corneas and no active ocular disease. * has had an ocular examination in the last two years. has a distance contact lens prescription between +0.50d to +6.00 ds and -0.50d and -12.00 ds. * has astigmatism less than or equal to -1.00dc. * agrees to wear the study lenses on a daily wear basis. * has a pair of glasses with updated prescription and agrees to wear them during the period no lens wear (7-10 days) as required by the study. exclusion criteria: a person is ineligible if he/she: * has undergone corneal refractive surgery. * is aphakic. * has any active ocular disease. * has any systemic disease affecting ocular health. * is using any systemic or topical medications that may affect ocular health. * has a known sensitivity to the diagnostic pharmaceuticals to be used in the study. * is pregnant or lactating. * is participating in any other clinical or research study. * has a known clinically significant sensitivity to the contact lens care solutions used in the study. * has ocular or systemic allergies that could adversely affect contact lens wear. * currently wears lenses on a continuous or extended wear basis. * has any ocular pathology or severe insufficiency of lacrimal secretion (dry eyes) that would affect the wearing of contact lenses. * has pinguecula/pterygium that, in the investigator's judgment, makes contact lens wear inadvisable. * is a rigid lens wearer. * has corneal staining graded as 2 (macropunctate) or greater in any corneal region in either eye, sum of corneal staining type (severity) of greater than or equal to 4 across the entire cornea in either eye, or any corneal staining covering greater than or equal to 20% in any corneal region in either eye.
study on osseospeed™ tx narrow implants in the lower jaw in a chinese population

Conditions: Partially Edentulous Jaw

Summary: the purpose of this study is to investigate the clinical efficacy of osseospeed™ tx 3mm diameter implant in a chinese population by evaluation of marginal bone level alteration, implant stability and implant survival in the posterior mandible up to 3 years after loading. hypothesis: early loading of the 3 mm implant is a safe and predictable procedure.


Eligibility criteria:
inclusion criteria: 1. provision of informed consent 2. aged 20-75 years at enrolment 3. history of edentulism in the study area of at least two months 4. presence of natural teeth, partial prosthesis and/or implants in the opposite jaw in contact with the planned crowns 5. deemed by the investigator to have a bone height and width suitable for 3.0 mm diameter study implant 6. deemed by the investigator as likely to present an initially stable implant situation exclusion criteria: 1. unlikely to be able to comply with study procedures, as judged by the investigator 2. uncontrolled pathologic processes in the oral cavity 3. known or suspected current malignancy 4. history of radiation therapy in the head and neck region 5. history of chemotherapy within 5 years prior to surgery 6. systemic or local disease or condition that could compromise post-operative healing and/or osseointegration, as deemed by the investigator 7. uncontrolled diabetes mellitus 8. corticosteroids or any other medication that could influence post-operative healing and/or osseointegration 9. smoking more than 10 cigarettes per day 10. present alcohol and/or drug abuse 11. involvement in the planning and conduct of the study (applies to both astra tech staff and staff at the study site) 12. previous enrollment in the present study 13. simultaneous participation in another clinical study, or participation in a clinical study during the last weeks prior to enrollment