Kornimate/medical-research-clean huggingface dataset:
smart autonomous neuro-rehabilitation system

Conditions: Cognition Disorders; Cognitive Deficits

Summary: cognitive rehabilitation is defined as a systematic functionally oriented intervention of therapeutic cognitive activities based on the assessment and understanding of patient's brain behavior deficits. this project focuses on restoring cognitive functions in order to understand the underlying deficits in the patient's brain by developing integrated cognitive rehabilitation scenarios in virtual reality that combine memory, attention and problem solving training with context specific motor movements.


Eligibility criteria:
inclusion criteria: * score on mini-mental state examination between 18 - 24 * score on montreal cognitive assessment less than 26 * more than 2 points in upper limb motor scale mrc * sufficient cognitive ability to understand and follow the experimental instructions exclusion criteria: * score on mini-mental state examination below 18 or above 24 * score on montreal cognitive assessment of 26 or above * below 2 point in upper limb motor scale mrc * hemianopia * cognitive capacity that prohibits the execution of the experiment * severe impairment like spasticity, aphasia or apraxia, major pain or other neuromuscular impairments or dependent on use of orthopedic devices that would interfere with the correct execution of understanding of the experiment * history of serious mental-health problems in acute or subacute phase * patients that do not give their consent to participate in the study

Keywords: cognitive rehabilitation memory attention spatial neglect executive dysfunctioning
assessment of immune response in multiple sclerosis patients with covid-19/vaccination treated with ofatumumab and other disease modifying therapies

Conditions: Multiple Sclerosis

Summary: vaccine responses in patients treated with anti-cd20 antibodies (ocrelizumab and ofatumumab) or s1p receptor modulators (fingolimod and siponimod) were evaluated before and after third sars-cov-2 vaccination as part of an ongoing longitudinal study. total spike protein and spike receptor binding domain (rbd)-specific immunoglobulin g (igg) responses were measured by luminex bead-based assay. spike-specific cd4+ and cd8+ t cell responses were measured by activation-induced marker expression.


Eligibility criteria:
inclusion criteria all participants: * aged 18-75 years old ms patients * diagnosed with ms based on 2017 mcdonald criteria exclusion criteria all participants: * participants with a known history of covid-19 healthy adults * immunocompromised or on immunosuppressive therapy ms patients * none specified
the effects of low resistance training on the residents in nursing homes

Conditions: Elderly Residents

Summary: this study will examine the effects of low-resistance elastic band training on muscle strength, flexibility, quality of life and ease of care among the residents in nursing homes.

regular exercise and dynamic life style can prevent and treat disability, as well as promote mental health and quality of life. in addition to chronic illness, reduced muscle mass and strength as part of aging, affect the daily activities of living of the elderly and their independent lifestyle. in fact, exercise had found positive effects on lower limb weakness of the elderly. elastic band is a resistance training aid which can be used for different muscle weight training. the research results have been demonstrated elastic band resistance training is safe and effective strategy to apply in the elderly population and to improve physical fitness, and mental functioning. therefore, this study will examine the effects of low-resistance elastic band training on muscle strength, flexibility, quality of life and ease of care among the nursing home residents. nursing homes with more than 50 beds that will be recruited in qingshui and waipu district taichung city. nursing homes will be randomly assigned to the experimental group and the comparison group. each group has 20 subjects. the residents in experimental group will receive a low-resistance elastic band training(30 minutes), including warm-up and cold-down period, three times per week for 10 weeks. residents in control group will receive regular activity in nursing home. inclusion criteria for the elderly include: (1) living in nursing home over 3 months; (2) communicating with mandarin and taiwanese; (3) being able to sit in a chair or wheelchair; (4) can grip elastic band by hands; (5) no severe cardiovascular disease, musculoskeletal disorders and mental illness;(6) consciousness intact and their consent to participate in this study. two structured questionnaires and an assessment checklist of muscle strength, flexibility will be used to collect data at baseline, week 8 and week 12 of exercise. the collected data will be coded and double checked and analyzed by using spss window release 20.0. the findings of this study can be apply to develop and conduct an effective exercise program through elastic band resistance training to improve residents' strength, flexibility, quality of life and care of ease in taiwan.

Eligibility criteria:
inclusion criteria: * living in nursing home over 3 months * communicating with mandarin and taiwanese * being able to sit in a chair or wheelchair * can grip elastic band by hands * consciousness intact and their consent to participate in this study exclusion criteria: * severe cardiovascular disease, musculoskeletal disorders and mental illness

Keywords: elastic band resistance training nursing home residents muscle strength flexibility quality of life ease of care
effect of laser acupuncture on constipation in patients with advanced cancer

Conditions: Constipation; Advanced Cancer

Summary: constipation is one of the most common complications in patients with advanced cancer. the aim of this protocol designed as a double-blind randomized controlled trial is to investigate the efficacy of laser acupuncture (la) therapy on constipation in patients with advanced cancer.


Eligibility criteria:
inclusion criteria: * aged 20 years or older * principal diagnosis of advanced cancer * diagnosis of constipation * treat with laxatives for at least 1 week but still have symptoms of constipation exclusion criteria: * intestinal obstruction * disturbance of consciousness * active gastrointestinal bleeding * active intraabdominal infection * local skin infection on the acupoints or limb amputees.

Keywords: constipation acupuncture laser acupuncture advanced cancer
glucagon like peptide 1 receptor (glp1r) expression and beta-cell mass in patients with type 2 diabetes

Conditions: Diabetes Mellitus; Diabetes Mellitus, Type 2

Summary: validation of the exendin-based beta cell imaging technique in patients with type 2 diabetes

rationale: reliable imaging biomarkers for non-invasive characterisation of beta-cell mass (bcm) are needed to aid understanding regarding the relationship between beta-cell mass and function during the course of type 2 diabetes (t2d). this study will provide critical information necessary to validate the applicability of exendin-based imaging techniques in patients with t2d. the characterization of beta-cells is currently limited to pancreatic specimens available at autopsy, as in vivo pancreatic biopsy is associated with complications unacceptable in clinical studies. to date, only measurements of circulating c-peptide and insulin levels can be obtained, but these measures do not reflect beta-cell mass, only total beta-cell function. reliable imaging biomarkers for non-invasive characterisation of beta cell mass are therefore needed. these biomarkers could also be used to validate novel therapeutic strategies aimed to increase or preserve bcm or identify whether patients are eligible for a certain therapeutic strategy (e.g. when certain amount of beta-cells is required). one can also think of identifying early responders to therapies, to avoid unnecessary drug use and the accompanying costs. the objective of this study is to determine the specificity of exendin-4 during the course of t2d and to examine the role of glycemic control on the correlation between pancreatic exendin-4 uptake, bcm and glp-1r expression in patients with t2d undergoing (partial) pancreatectomy. this will allow examination of the role of glycemic control on exendin uptake in humans, but also implementation of clinical guidelines for the interpretation of clinical exendin-based scans in patients with t2d to avoid false interpretation of the scans.

Eligibility criteria:
inclusion criteria: * scheduled for partial or complete pancreatectomy at radboudumc exclusion criteria: * previous treatment with synthetic exendin or dipeptidyl-peptidase iv inhibitors within the past 3 months * breast feeding * pregnancy or the wist to become pregnant within 6 months * creatinine clearance below 40ml/min * liver disease defined as aspartate aminotransferase of alanine aminotransferase level of more than three times the upper limit of normal range

Keywords: nuclear imaging beta cell mass exendin-4
pericapsular nerve group block for total hip arthroplasty

Conditions: Hip Arthropathy; Postoperative Pain

Summary: controlling pain after hip replacement surgery improves comfort and partient satisfaction. pain after hip replacement has traditionally been managed using systemic pain medications including acetaminophen and non-steroidal anti-inflammatory drugs. a recent cochrane review demonstrated that compared to systemic analgesia alone, peripheral nerve blocks reduce postoperative pain with moderate-quality evidence. pericapsular nerve group block is a new technique allowing local anesthetic diffusion to femoral, obturator and accessory obturator nerves and providing a good analgesic effect for hip fracture surgery. investigators hypothesized that the peng block could be an interesting alternative to systemic analgesiscs for pain control after total hip replacement.

the aim of the study was to evaluate the efficacy of the peng block for intra and postoperative pain control in total hip arthroplasty. it was a monocentric, randomized, controlled and double blind study. patients scheduled for primary tha with lateral approach under general anesthesia. premedication with iv midazolam 1 to 2 mg on arrival to operating theatre. general anesthesia was conducted using fentanyl, propofol and cisatracurium for induction and isoflurane for maintanance patients were randomized using a random table in two groups: * peng block group (pg) who received 2 mg.kg-1ropivacaine in 40 ml of saline. * placebo group (sg) who received 40 ml of saline. postoperative analgesia started before extubation of the patient, with: * iv paracetamol 1g/6h in day1 and oral paracetamol 1g/8h for 6 days. * non steroidal anti inflammatory drugs with im piroxicam 20 mg on day one (at the end of surgery) and oral diclofenac 50 mg/12h for 3 days. * morphine pca for day 1 (24 h) and oral tramadol 50 mg/12h from day 2 to day 6.

Eligibility criteria:
inclusion criteria: * primary tha with lateral approach under general anesthesia. exclusion criteria: * hip fracture, * allergy to local anesthetics, * peripheral neuropathy, * creatinin clearance inferior to 30ml/min, * weight inferior to 50 kg or superior to 100 kg, * neurological disorder affecting the lower extremity, significant psychiatric conditions, * patients receiving corticosteroid therapy, * chronic consumption of opioids (\>2 months).

Keywords: hip arthoplasty nerve block analgesia
technology platform and system construction of clinical evaluation studies on new drugs of hematological malignancy

Conditions: Multiple Myeloma

Summary: multiple myeloma (mm) is the second diagnosed malignancy of hematological malignancies. the previous study pointed out that the dosage and course of bortezomib including the dose of concomitant drugs used to treatment mm patients did not get the preferred treatment program, so we are going to determine the optimal doses and course of bortezomib through the prospective, multicenter clinical trial and evaluate the efficiency and safety of different program.


Eligibility criteria:
inclusion criteria: 1. obtain informed consent form (icf) signed by patients or its relative. 2. patients newly diagnosed multiple myeloma (mm). (not include patients with multiple solitary extramedullary plasmacytoma and those atⅰstage of durie-salmon staging system) 3. measurable serum protein: igg type of mm: serum m-protein≥ 1.0g/dl or urine m-protein≥ 200mg/24h. iga type of mm: serum m-protein≥0.5g/dl or urine m-protein≥200mg/24h. igm type of mm: (igm m-protein and osteolytic lesion showed in x-ray):serum protein≥ 1.0g/dl or urine m-protein≥ 200mg/24h. igd type of mm: serum m-protein≥0.05g/dl or urine m-protein≥200mg/24h. light chain type of mm: serum m-protein≥ 1.0g/dl or urine m-protein≥ 200mg/24h. 4. physical score 0\~2 grade(who standard), and able to comply with the visit time and protocol requirements. exclusion criteria: 1. diagnosed with relapsed multiple myeloma. 2. any serious diseases which may lead patients suffer from unaccepted risk. 3. female patients who is pregnant or breast-feeding. 4. histories of other malignant tumors other than mm, except those patients whose disease have been cured for at least 3 years. exception: basal-cell carcinoma, squamous cell carcinoma, carcinoma in situ of uterine cervix, breast carcinoma in situ,occasionally prostatic cancer histological discovery(at stage t1a or t1b defined as tnm classification). 5. not be able to understand or comply with the investigate protocol. 6. patients with grade 2 or higher peripheral neuropathy before treatment.
what is the optimal technique for hydrodistention?

Conditions: Interstitial Cystitis; Bladder Pain Syndrome

Summary: this research study is being done to learn what is the best way to perform hydrodistention. eligible participants will be enrolled and have follow-up for three months after surgery. the study team hypothesizes that changes in hydrodistention technique, including pressure, number of distention, and duration of distention, leads to no or minimal changes in symptom improvement for patients with interstitial cystitis/bladder pain syndrome (ic/bps).

hydrodistention is a procedure designed to treat bladder and pelvic symptoms in patients with interstitial cystitis. a camera is placed inside the bladder and the bladder is filled with fluid. this procedure "resets" the signals between the bladder and brain, in order to reduce the symptoms of interstitial cystitis (such as bladder pain, urinary urgency/frequency/dysuria, incontinence, incomplete emptying, etc). however, it is still unknown the best way to perform hydrodistention. doctors do not know how much fluid to put in the bladder, how long to keep the fluid in the bladder, and how many times to fill the bladder.

Eligibility criteria:
inclusion criteria: * patients with ic/bps who have failed first/second line treatments (behavioral therapy, medications) for greater than 3 months * have not had hydrodistention performed in the past 3 months * have not had botox or percutaneous tibial nerve stimulation (ptns) performed in the past 3 months exclusion criteria: * patients with known hunner's lesions * patients with interstim * patients with positive urinalysis/culture consistent with urinary tract infection (uti) * history of urethral, bladder, prostate, uterine, cervical, vaginal cancer * history of augmentation cystoplasty or cystectomy * history of urethral diverticulum, urethral stricture, pelvic radiation * patients with spinal cord injuries * history of dementia, parkinson's disease, multiple sclerosis, spina bifida, paraplegia/quadriplegia, cerebral palsy, stroke * neurogenic bladder patients * anuric patients * tuberculous cystitis * cyclophosphamide treatment * pregnant patients

Keywords: hydrodistension
cortical-basal ganglia speech networks

Conditions: Parkinson Disease; Essential Tremor; Dystonia

Summary: in this research study the researchers want to learn more about brain activity related to speech perception and production.

speech production is disrupted in a number of neurological diseases that involve the basal ganglia, including parkinson's disease (pd) and dystonia. the investigators will use a novel experimental approach and combination of analytic techniques to elucidate the contribution of neural activity in cortical-basal ganglia circuits to the hierarchical control of speech production, in subjects undergoing deep brain stimulation surgery.

Eligibility criteria:
inclusion criteria: 1. subjects scheduled for dbs implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of parkinson's disease, essential tremor or dystonia. 2. subjects able to provide informed consent and comply with task instructions. 3. subjects 18-85 years old exclusion criteria: 1. subjects with reported hearing loss. 2. non-english-speaking subjects
determination of product thickness applied on different areas of the face using a multispectral imaging method

Conditions: Sunscreen

Summary: the aim of the study is to determine: * the thickness of the rv4369a truly applied on different areas of the face after single application of the product determined by a multispectral imaging method. * the influence of a second application of the product 15 to 30 minutes after the first application on the product thickness determined by multispectral imaging method. * the influence of the recommendations of use provided to the subjects before application of the product on the product thickness determined by multispectral imaging method .

this study is a monocentric, comparative, open study performed on the face and forearms of healthy adults. planning of the visits: visit 1: inclusion visit (d1) visit 2: end of study visit (d10), a window of +/- 2 days is allowed for this evaluation, \* the theoretical study duration for each subject is 10 days. the maximal study duration for each subject is 12 days.

Eligibility criteria:
inclusion criteria: * dry, normal to combination skin * phototype i to v inclusive. * absence of significant facial hair. exclusion criteria: population * pregnant, breastfeeding women. * for men: moustached or bearded. * substantial hair on the forearm and face. * application of keratolytic or self-tanning products to the face, forearms and arms in the four weeks prior to inclusion. * with scars or other cutaneous characteristics, sunburn on forearms in the test areas, the size of which is considered incompatible with the study. * application of water, cleansing or beauty products to the forearms and arms since the last wash on the evening before inclusion. diseases : * known history of allergy to any of the investigational product ingredients. * known history of allergy to latex. * skin lesions or skin disease on the face or on the arms and forearms that may affect test results (seborrheic dermatitis, atopic dermatitis, psoriasis, acne, rosacea, etc.). treatments: * ongoing local or oral treatment (retinoids, anti-inflammatory) that may affect test results.
effects of instrument assisted soft tissue mobilization on pain, grip strength and functional activity in patients with lateral epicondylitis

Conditions: Lateral Epicondylitis; Tennis Elbow

Summary: this study aimed to find the effects of instrument assisted soft tissue mobilization (iastm) using ergon tools on pain, grip strength and functional activity among patients diagnosed with lateral epicondylitis. the study concluded that iastm is effective in improving pain, grip strength and functional activity in patients with lateral epicondylitis.

background: lateral epicondylitis is a type of "repetitive strain injury" that causes pain on the lateral portion of the elbow, especially while gripping and applying resistance to the forearm's extensor muscles, both men and women are equally affected by it. traditional physical therapy has failed to improve the disorders caused by le, instrument assisted soft tissue mobilization is a new approach for its treatment a lot of tools are being used and ergon tools are among one of them, very less data is available for its efficacy in lateral epicondylitis patients. objective: to compare the effects of instrument assisted soft tissue mobilization using ergon technique on pain, grip strength and functional activity in patients with lateral epicondylitis. methodology: 72 individuals with lateral epicondylitis pre-diagnosed by an orthopedic surgeon, are assessed from sikander medical complex, gujranwala. after fulfilling the inclusion criteria, the participants are randomly divided into two groups, 36 participants receiving iastm using ergon tools and 36 participants received conventional physical therapy. both groups receive treatment 2 times a week for 4 weeks. outcome measures are pain (vas), grip strength (handheld dynamometer), and functional mobility (prtee) collected at the baseline, 1st week, and 4th week.

Eligibility criteria:
inclusion criteria: * both male and female patients * patients between the age group 20-50 years * sub-acute patients having symptoms for \> 6 weeks and \< 3 months. * patients who had pain rating from 5 to 9 in vas will be included * patients with positive cozens test, mill's test exclusion criteria: * patients with any surgical or trauma history of the elbow * rheumatoid arthritis and malignancies * cervical radiculopathy patients who have referred pain in the elbow * loss of passive rom in extension * active infections such as, bursitis, calcification of the soft tissues, fragile skin, hyper mobility \& joint effusion * hemophilic patients * osteoporosis * patients with history of getting treatment with steroid injections will be excluded.

Keywords: iastm lateral epicondylitis tennis elbow pain grip strength functional activity
psychometric properties of the chinese version of penat

Conditions: Cancer; Child; Nausea; Vomiting

Summary: cancer is a leading cause of death for children. chemotherapy is the most common treatment for cancer. notwithstanding the improved survival, children with cancer still have to face a significant amount of symptoms associated with chemotherapy. two major symptoms induced by chemotherapy are nausea and vomiting. these two symptoms were demonstrated to cause serious disruption in patients' daily function and quality of life. given these devastating impacts, intervening children with appropriate methods to alleviate nausea and vomiting during chemotherapy is therefore crucial. it is imperative for nurses to develop non-pharmacological interventions to reduce nausea and vomiting, with the goal of improving the qol of children with cancer when undergoing chemotherapy first, however, careful assessment of nausea and vomiting in children with cancer is a necessary step towards designing appropriate interventions. this study aims to translate and validate an instrument (penat) which can assess nausea and vomiting among hong kong chinese children and adolescents undergoing chemotherapy

currently, the most effective anti-emetics appear to be 5-ht3 inhibitors, followed by nk1 inhibitors and neuroleptic drugs. nevertheless, anti-emetics alone are not sufficient to manage these two symptoms. this poor symptom control could be due to healthcare professionals' perception that nausea and vomiting are solely biological problems, and their heavy reliance on pharmacological treatment for management. after literature search, we can identify only one validated instrument, the pediatric nausea assessment tool (penat), assessing chemotherapy-induced nausea and vomiting in children. yet, this instruments is not available in chinese. this study aims to translate and validate an instrument (penat) which can assess nausea and vomiting among hong kong chinese children and adolescents undergoing chemotherapy

Eligibility criteria:
inclusion criteria: * aged 4 - 17 * a confirmed diagnosis of cancer * currently undergoing chemotherapy * able to speak cantonese and read chinese exclusion criteria: * cognitive or behavioral problems in medical records