Kornimate/medical-research-clean huggingface dataset:
plasma biomarkers of cardiopulmonary bypass induced acute respiratory distress syndrome (cpb-ards)

Conditions: Acute Respiratory Distress Syndrome

Summary: the investigators aimed to establish a prospective cohort of patients undergoing cardiopulmonary bypass (cpb) in cardiac surgery from april 2021 to september 2022, in wuhan. the ards events, ventilation time, time of extubation, oxygenation index for 3 days after operation were observed. plasma samples were collected before cpb, and several time points after cpb. dynamic differential proteins of ards after cpb were screened by dia (data independent acquisition) proteomics. quantitative protein marker concentration was used to predict the occurrence of ards after operation, the model discrimination and calibration was assessed.


Eligibility criteria:
inclusion criteria: * selective operation; * cardiac surgery with cardiopulmonary bypass; * adult patients over 18 years old; * signed informed consent exclusion criteria: * patients who refuse to sign the informed consent form or the attending physician refuses the patient to join the study; * non elective surgery (surgery at non-elective time or emergency surgery); * preoperative pulmonary insufficiency, pulmonary hypertension and pulmonary inflammation; * the absence of any specimen and clinical data; * patients who failed the operation, needed extracorporeal membrane oxygenation support or underwent cpb operation again within 3 days after operation;

Keywords: acute respiratory distress syndrome biomarkers proteomics cardiopulmonary bypass
comparative analysis of core body temperature measurement

Conditions: Temperature Change, Body

Summary: comparison and evaluation of the correlation, accuracy, and precision between a skin-attached temperature sensor and the standard method of deep body temperature measurement, the esophageal thermometer, by measuring and assessing both temperature measurement methods.


Eligibility criteria:
inclusion criteria: * healthy adults aged 19 years and above, but under 70 years exclusion criteria: * cases where there were serious side effects during a previous examination performed under sedation or anesthesia * currently undergoing treatment for a diagnosed disease * diagnosed with esophageal varices or having a history of esophagitis * having undergone esophageal and gastric resection surgery

Keywords: esophageal temperature 3m spot on zero heat flux temperature
pharmacokinetic/pharmacodynamic evaluation amikacin in critically ill patients admitted at the emergency department

Conditions: Sepsis

Summary: the aim of the study is the evaluation of pk/pd target attainment of amikacin in ed patients with severe sepsis and septic shock.


Eligibility criteria:
inclusion criteria: - patients admitted at the emergency department with a diagnosis of severe sepsis or septic shock in whom amikacin is indicatied exclusion criteria: * \< 18 years * pregnancy * burns * amikacin treatment in the previous 2 weeks * known allergy to aminoglycosides * do not reanimate code ≥ 2 * hospitalized patients with a prolonged deep venous or arterial catheder * continuous renal replacement, intermittent hemodialysis and death within the time of start of amikacin replacement and 1 hour later

Keywords: pharmacokinetics aminoglycosides
surgical treatment of fractures of the dorso-lombar spine

Conditions: Spine Fracture

Summary: trauma to the thoracolumbar spine is responsible for potentially serious lesions, most often involving the functional prognosis in the short, medium and long term, and rare the frequency of these traumas is explained by falls from high places, especially during work accidents or suicide attempts, but also by the perpetual increase in accidents on public roads ly the vital prognosis

trauma to the thoracolumbar spine is responsible for potentially serious lesions, most often involving the functional prognosis in the short, medium and long term, and rarely the vital prognosis . the thoracolumbar spine has an extended transition zone between the tenth thoracic vertebra (t10) and the second lumbar vertebra (l2): the thoracolumbar hinge which, given its particular anatomical situation between a poorly mobile thoracic segment and a dynamic lumbar segment, is the predilection for occurrence of fractures and dislocations . the frequency of these traumas is explained by falls from high places, especially during work accidents or suicide attempts, but also by the perpetual increase in accidents on public roads. the analysis of the lesion mechanism and its consequences depends on the understanding of the classification of these lesions which are essential for therapeutic conduct . surgical treatment constitutes a key element in the management strategy for these fractures

Eligibility criteria:
inclusion criteria: * the files of patients hospitalized for a recent fracture of the thoracolumbar spine within 12 months exclusion criteria: * files with insufficient follow-up, patients lost to follow-up. patients presenting: a pathological fracture. osteoporotic collapse. material and methods 3 staged trauma to the spine. a fracture due to ankylosing spondylitis

Keywords: fractures spine surgery treatment evaluation results
screening to improve survival in al amyloidosis

Conditions: Smoldering Multiple Myeloma; Monoclonal Gammopathy of Undetermined Significance

Summary: the purpose of this study is to see whether certain genes may be linked with the development of al amyloidosis in subjects 60 years of age or older with the blood disorders smm and mgus. a limited repertoire of immunoglobulin (ig) variable region genes have been associated with al amyloidosis. the clonal plasma cells of subjects with smm and mgus may express one of these ig variable region genes indicating a risk of progression to al amyloidosis and potentially enabling early diagnosis. we hope this study will help us begin to understand whether ig variable region gene identification can be a useful tool for assessing a subject's risk of progression to al amyloidosis.


Eligibility criteria:
inclusion criteria: * patients 60 years of age and older * diagnosed with λ lc mgus or λ lc smm * dflc greater than 23 mg/l and κ::λ free lc ratio below normal * if the patient has an egfr less than 50 ml/min/1.73m2, the κ::λ free lc ratio is inconsequential. the patient only needs to meet the age, dflc, and λ lc mgus or λ lc smm diagnosis criteria in this case exclusion criteria: * patients with κ lc mgus or κ lc smm * amyloid in the bone marrow or in other biopsies will not be included * patients younger than 60 years of age are not eligible

Keywords: smm mgus al amyloidosis
effects of power ball on proximal muscle and refractive errors in developmental delay.

Conditions: Developmental Delay

Summary: when a child does not meet developmental milestones at the anticipated times, it is referred to as having a developmental delay. these benchmarks cover social, emotional, cognitive, physical, and communication abilities. developmental delays can result from a number of factors, including genetic circumstances, early delivery, specific medical issues, or external variables. although they mainly impair vision, refractive errors are unrelated to developmental delays. because vision facilitates interaction with the environment, it is vital to a child's development. early detection of uncorrected refractive defects and related vision loss in children can pose a challenge. to ascertain whether an increase is suitable and successful, a thorough evaluation of the child's readiness and the application of pertinent measurement techniques may be necessary. an analysis looks into randomized controlled trial will be the type of study design used. there will be two groups of conveniently randomized sample size of thirty-two. the data analysis will be done using spss version 22.0. to verify normality, the shapiro-wilk test will be employed. the study will be carried out in the department of physical therapy of the rising sun and the lahore rehab facility. the study will be finished six months from the time the synopsis is approved. a sample size of thirty-two was determined using the openepi tool. the vqol/item tool and pediatric manual muscle testing will be used. for four weeks, the control group will receive standard physical therapy care. group b: experimental group: for five weeks, a traditional physical therapy regimen and powerball exercises will be administered.

group a: conventional physiotherapy will be administered to this group. manual resistance exercises for neck strengthening are part of conventional physical therapy. cervical flexion, extension, side flexion, side flexion with rotation, and pure rotation with mild resistance are the exercises used to strengthen the neck. there will be three 30-minute sessions. strengthening will take place over the course of 15 mints. group b: in addition to standard care, this group will engage in power ball exercises for neck stability and strengthening. gradually, the resistance will rise. three mints in each position for a total of fifteen mints of ball exercises. at first, powerball reduced the pain, progressively strengthened them, and with continued development, allowed them to move in a pain-free range.

Eligibility criteria:
inclusion criteria: * age 7-12 years * both genders * children with refractive error * children with affected developmental delay exclusion criteria: * any neurological condition (epilepsy and seizures) * any congenital defects * genetic disorder * surgery in last 6 months

Keywords: developmental delay refractive error power ball muscle control
rose bengal electromagnetic activation with green light for infection reduction ii

Conditions: Bacterial Keratitis

Summary: rose bengal electromagnetic activation with green light for infection reduction ii (reagir ii) is a randomized, double-masked feasibility study. the purpose of this study is to determine differences in 6-month visual acuity between medical antimicrobial treatments alone versus antimicrobial treatment plus cross-linking with rose bengal (rb-pdt). patients presenting to one of the aravind eye hospitals in india or to the federal university of são paulo ophthalmology clinic in brazil with smear-positive and/or culture positive typical (i.e. non-nocardia or mycobacteria) bacterial corneal ulcers and moderate to severe vision loss, defined as snellen visual acuity of 20/40 of worse, will be eligible for inclusion. those who agree to participate will be randomized to one of two treatment groups: * group 6, rb-pdt plus early steroids: topical 0.5% moxifloxacin plus topical difluprednate 0.05% plus rb-pdt * group 7, sham rb-pdt plus early steroids: topical 0.5% moxifloxacin plus topical difluprednate 0.05% plus sham rb-pdt


Eligibility criteria:
inclusion criteria: * corneal ulcer that is smear positive and/or culture positive (within 24 hours) for typical bacteria (i.e. non-nocardia or myobacteria) * moderate to severe vision loss, defined as snellen visual acuity of 20/40 (6/12) or worse * corneal thickness ≥350 µm, as measured on as-oct * age over 18 years * basic understanding of the study as determined by the physician * commitment to return for follow up visits exclusion criteria: * evidence of concomitant infection on exam, gram stain, or confocal microscopy (i.e. herpes, both bacteria and acanthamoeba on gram stain) * impending or frank perforation at recruitment * involvement of sclera at presentation * presence of desmetocele at recruitment * non-infectious or autoimmune keratitis * history of corneal transplantation * history of intraocular surgery within the last three months\* * pinhole visual acuity worse than 20/200 in the unaffected eye * participants who are decisionally and/or cognitively impaired
safety, tolerability, analgesic effect, and feasibility of intranasal ct001 in pediatric patients

Conditions: Pain

Summary: the proposed study aims to investigate the safety, tolerability, analgesic efficacy, and feasibility of intranasal sufentanil/ketamine (ct001) in pediatric participants attending an acute care (i.e. emergency) setting. the study is a part of the clinical development plan for the development of ct001 nasal spray for treatment of acute pain in children.


Eligibility criteria:
inclusion criteria: * pediatric participant, age 1 year to 17 years * attending an emergency department following an injury * acute pain of moderate or severe intensity * obtained informed consent by parent/guardian and assent from the child if possible and relevant (age dependent) exclusion criteria: * participant showing abnormal nasal cavity/airway such as: 1. major septal deviation 2. evidence of previous nasal disease or surgery 3. current significant nasal congestion due to common cold * has received treatment with sufentanil and/or ketamine during the last 72 hours * known or suspected allergy to ketamine or sufentanil * critical, life- or limb-threatening condition requiring immediate management
impact of local steroid application in extreme lateral lumbar interbody fusion

Conditions: Stenosis; Herniated Nucleus Pulposus; Degenerative Disc Disease; Spondylosis; Myelopathy; Radiculopathy; Myeloradiculopathy

Summary: neural injury is a well-known complication following extreme lateral lumbar interbody fusion (xlif). it has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit. this occurs with traversal of the psoas muscle or direct injury to lumbosacral plexus or sympathetic ganglion. while often temporary, it can cause hip flexor weakness, thigh numbness, or pain. several studies have demonstrated reduced patient reported pain scores following steroid administration, particularly in the early postoperative period. however, few studies have investigated the efficacy of intraoperative local injection of corticosteroid in reducing the incidence and duration of postoperative pain or neurologic injury for xlif patients.

the purpose of this study is to determine if the incidence and duration of postoperative pain is reduced in the subjects receiving a local injection of methylprednisolone when compared to placebo following xlif. the investigators hypothesize that subjects undergoing xlif who receive local methylprednisolone will have: 1. reduced incidence and duration of postoperative pain and neurologic injury 2. shorter hospital stay 3. better short- and long-term outcomes the study also aims to answer the following questions: 1. do subjects who receive local corticosteroids have a reduced incidence and duration of postoperative pain and neurologic deficit compared to those who receive placebo? 2. do subjects who receive local corticosteroids have a reduced hospital stay compared to those who received placebo? 3. is local corticosteroid therapy associated with improved short and long-term outcomes?

Eligibility criteria:
inclusion criteria: * patients undergoing a 1- to 2-level xlif * diagnosis: myelopathy, radiculopathy, myeloradiculopathy, stenosis, herniated nucleus pulposus, degenerative disc disease, spondylosis, osteophytic complexes, and foraminal stenosis * patients able to provide informed consent exclusion criteria: * allergies or other contraindications to medicines in the protocol including: * existing history of gastrointestinal bleeding * lumbar spine trauma * unable to speak, read, or understand english
dose escalation safety and pharmacokinetic study of ave9633 as single agent in relapsed/refractory cd33-positive acute myeloid leukemia

Conditions: Myeloid Leukemia

Summary: the primary objective is to determine the maximum tolerated dose of ave9633 and to characterize the dose limiting toxicity(ies). secondary objectives are to determine the anti-leukemia activity, the global safety and the pk profile.


Eligibility criteria:
inclusion criteria: * patients with cd33-positive acute myeloid leukemia, refractory or relapsed after standard treatment with no curative option available * ecog performance status 0 to 2 exclusion criteria: * therapy with gemtuzumab ozogamicin (mylotarg) within 6 months prior to inclusion * allogenic transplantation within 6 months prior to inclusion * prior therapy (chemotherapy, targeted agents, radiotherapy) within 3 weeks except for hydroxyurea and for leukophoresis * previous treatment with ave9633 * poor kidney, liver and bone marrow functions * any serious active disease or co-morbid condition, which in the opinion of the principle investigator, will interfere with the safety or with compliance with the study * pregnant or breast-feeding women * patient with reproductive potential without effective birth control methods the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
impact of eslicarbazepine acetate on lipid metabolism and cardiovascular risk factors

Conditions: Epilepsy

Summary: knowing the impact that the use of esl as adjunctive treatment of partial epilepsy has on cardiovascular risk factors measured by biochemical and ultrasound parameters compared with enzyme-inducing aeds.


Eligibility criteria:
inclusion criteria: * patients over 18 years * patients definitively diagnosed focal epilepsy based on clinical criteria and additional tests. * patients with stable and identifiable antiepileptic treatment during the last two years. * patients according to the investigator are able to provide clinical data necessary for the development of the study * patients who signed informed consent exclusion criteria: * patients who, according to their evolution and demands of clinical practice, their previous treatment has to be changed for this reason breach inclusion criteria and / or attachment to one of the study groups.
intervention to decrease anxiety in parents of infants in the neonatal intensive care unit (nicu)

Conditions: Anxiety; Acute Stress Disorder; Posttraumatic Stress Disorder; Depression

Summary: infants born premature face numerous medical problems, causing significant anxiety for their parents. parents experience a range of negative emotions including concern for the health and well being of their fragile infant, guilt, and disappointment. research has indicated that having an infant in the neonatal intensive care unit (nicu) is highly stressful for parents and multiple studies have demonstrated that parents can develop significant psychological reactions to this experience. specifically, many parents develop clinically significant anxiety disorders such as acute stress disorder (asd) and posttraumatic stress disorder (ptsd). this not only impacts the mental well-being of the parents, but also can lead to problems with the parent-infant relationship, and, in turn, negatively impact the infant and the family as a whole. despite the reported negative effects parents experience due to the stress of having an infant on the nicu, surprisingly little research has examined how to reduce parents' symptoms of anxiety. because parents play an essential role in the care of their infant after discharge from the nicu, treating the parent's emotional distress is highly important. the purpose of this study is to examine the efficacy of a cognitive-behaviorally based intervention in reducing parents' symptoms of anxiety associated with having an infant on the nicu. this treatment is modeled after treatments that have proven effective with parents of children with other types of medical problems, for example, parents of children with cancer. it is the hope of the investigators that this intervention will effectively reduce symptoms of anxiety of nicu parents as well as the likelihood of developing subsequent psychological disorders.


Eligibility criteria:
inclusion criteria: 1. 18 years of age or older; 2. participants speak either english or spanish; 3. the participant's infant is expected to live; 4. the participant's infant was born at lucile packard children's hospital or transferred to the hospital within 72 hours; 5. participant's infant is over 1000 grams exclusion criteria: 1. individuals under 18 years of age; 2. individuals who do not speak either english or spanish; 3. individuals whose infant was not born at or transferred to (within 72 hours of the infant's birth) lucile packard children's hospital; 4. individuals whose infant has a life threatening condition and is not expected to survive; 5. current drug abuse/dependence
attitude of egyptian population toward covid 19 in ramadan

Conditions: Covid 19

Summary: during the covid 19 pandemic and after new cases started to appear in egypt in march 2020 the egyptian government issued movement restrictions and placed areas into quarantine to reduce the spread of the virus. egyptian citizens were encouraged to adopt personal protective measures, such as staying at home , increasing personal hygiene and wearing protective face masks. ramadan is a holy month and a very special event for all the muslims worldwide including the egyptian muslims . the egyptians have many rituals and traditions special for ramadan . normally egyptian people tend to go to family gatherings and go out for iftar and suhoor in ramadan .the markets also tend to be very crowded and full of people in ramadan for buying food and other preparations for ramadan and eid al fitr. this all can lead to crowdingof people in the streets and markets and increases the chance of the spread of the virus and the chance of infection.public awareness play a major rule in reducing the spread of covid 19 so in this study a survey is done to measure the attitude of the egyptian population toward covid 19 in ramadan and to evaluate if the rituals and traditions in the holy month are affecting the spread of covid 19 in egypt.

the survey will enroll as many individuals of the egyptian population as possible in the survey portion of the study - the number of participates have no limitations, at least 500 participants. the survey will be enrolled in online google form, face to face interview(this will be reduced to encourage social isolation) \& semi-structured telephone interviews if possible. the research procedures: an online survey link will include questions regarding the attitude and behaviour of the egyptian population during the covid-19 outbreak in ramadan and to evaluate if people are practicing their normal rituals and traditions in the holy month and how can this affect the covid 19 spread in egypt. face to face and semi-structured interviews if possible: for those egyptian citizens who state that they would like to participate in an interview, a random sample will be contacted. inclusion criteria: egyptian population of any age group exclusion criteria: none

Eligibility criteria:
inclusion criteria: egyptian population exclusion criteria: none
renal denervation by ultrasound transcatheter emission

Conditions: Resistant Hypertension

Summary: the realise trial is a single-arm, open-label, prospective, post market evaluation to be conducted on twenty (20) eligible patients with a twelve month follow-up period.


Eligibility criteria:
inclusion criteria: * resistant hypertension, as defined in the 2007 esh-esc guidelines * 18 years of age or older * negative pregnancy test for female patients of childbearing potential * willing and able to comply with follow-up requirements * signed informed consent exclusion criteria: * secondary hypertension * main renal arteries length \< 20 mm * main renal arteries diameter \< 4 mm * renal artery stenosis * iliac/femoral artery stenosis precluding insertion of the catheter * allergy to contrast media * currently participating in the study of an investigational drug or device * hemodynamics abnormality * moderate to severe renal insufficiency

Keywords: hypertension blood pressure renal denervation