Kornimate/medical-research-clean huggingface dataset:
the effect on depressive symptoms in ecf residents with copd

Conditions: Chronic Obstructive Pulmonary Disease; Depression

Summary: the purpose of this study is to assess the effect of treatment with advair diskus on depression using the cornell depression scale in copd patients in the nursing home.

we are studying 35 residents in the ecf with a diagnosis of copd. we are evaluating them for depressive symptoms using the cornell depression scale and the mds 3.0 section d. we are selecting patients who are not currently on treatment with advair and starting them on advair diskus50/250 1 inhalation bid for a period of 16 weeks and reassessing the cornell depression scale and mds3.0 section d looking for any changes. we are also going to measure fev1 and fvc using spirometry before treatment and at the end of 16 weeks. this is a pilot study. the numbers are not necessarily adequate to achieve statistical difference-we are looking for trends.

Eligibility criteria:
inclusion criteria: * adult men and women nursing home residents up to age 95 * stated diagnosis of copd or fev1/fvc \<0.7 or being treated with an anticholinergic * presence of depressive symptoms as measured on mds 3.0 section d sum * free from conditions likely to be fatal within six months * able to read or understand english * able and willing to provide informed consent or has a guardian/lar who can provide informed consent exclusion criteria: * currently pregnant * unable to read and understand english * free from conditions likely to be fatal within six months * enrolled in hospice * new treatment with antidepressant within the last 90 days. * current or recent use (within the last 90 days) of advair diskus * unwilling or unable to provide informed consent * expected to be discharged within 3 months

Keywords: copd depression nursing home
effect of neuromuscular stimulation and mindfulness breathing in patients with stroke

Conditions: Stroke

Summary: it is an interventional study in which 60 stroke patients were estimated to enroll according to random allocation and divided into two groups. the experimental group will receive neuromuscular stimulation and mindfulness breathing, while the control group will receive neuromuscular stimulation only.

it is an interventional study in which 60 stroke patients will be estimated to enroll according to random allocation and divided into two groups. the experimental group will receive neuromuscular stimulation and mindfulness breathing, while the control group will receive neuromuscular stimulation only. the experimental group participants will receive neuromuscular electrical stimulation that will last 12 consecutive weeks, three sessions per week protocol with mindful breathing is a mindfulness exercise that involves using breathing as an object of attention.

Eligibility criteria:
inclusion criteria: * the subject selection will be according to the following criteria: * all patients of this study will be diagnosed as stroke and the diagnosis will be confirmed by computed tomography or mri (el-tamawy et al., 2021). * age of patients will be ranged from 50 to 65years (males and females). * all patients will be hemodynamically stable. * patients with good cognition that enables them to understand the requirements of the study. exclusion criteria: * • the potential participants will be excluded if they meet one of the following criteria: * patients who cannot follow instructions as sensory aphasia, blindness, dementia, and deafness. * patients with any orthopedic, neurological, or chest disorders that affect trunk muscles control or cause respiratory disorders as copd. * patients with cognitive and psychiatric disorders. * patients with unstable cardiovascular conditions. * patients with contraindications to neuro electrical stimulation as: * cardiac pace maker. * acute abdominal surgery.
efficacy of partial covered double bare metal stent compared to uncovered double bare metal stent in malignant biliary obstruction

Conditions: Malignant Tumor

Summary: previous studies indicated that covered stents are less likely to become occluded in comparison to bare stents. while the probability of occlusions caused by tumor in-growth is less in covered stents, they are more likely to spontaneously migrate to a position that is distal to the original deployment site. however, newer covered stents with improved designs, such as the partially covered double bare metallic stent used for this study, include features to mitigate the migration issue. the purpose of this study is to confirm whether the difference in patency rate between regular covered stents and bare stents, which has already been well established by existing studies, is also reproducible when double covered stents are compared against double bare stents.

malignant obstructive jaundice is a common complication of advanced stage cholangiocarcinoma, gb cancer, and pancreatic cancer. in biliary stricture by malignancy, biliary drainage with placement of self-expanding metal stent (sems) for palliation is the therapy of choice in these patients. when compared to plastic stents, sems present a significantly decreased risk of recurrent biliary obstruction. sems are also more cost-effective than plastic stents in patients with a life expectancy of longer than 4 months. however, despite their numerous benefits, sems become occluded in up to 50 % of patients in the first 6-8 months. in order to minimize the occurrence of this issue, covered stents were developed. previous studies indicated that covered stents are less likely to become occluded in comparison to bare stents. while the probability of occlusions caused by tumor in-growth is less in covered stents, they are more likely to spontaneously migrate to a position that is distal to the original deployment site. however, newer covered stents with improved designs, such as the partially covered double bare metallic stent used for this study, include features to mitigate the migration issue. the purpose of this study is to confirm whether the difference in patency rate between regular covered stents and bare stents, which has already been well established by existing studies, is also reproducible when double covered stents are compared against double bare stents.

Eligibility criteria:
inclusion criteria: * pathologically confirmed malignant biliary obstruction or clinically defined malignant biliary obstruction * malignant biliary obstruction was located more than 1cm from the hilum * older than 20 years old * life expectancy \> 6 months * inoperable case due to advanced stage or comorbidity * informed consent obtained exclusion criteria: * inadequate case for ercp * failed endoscopic approach to duodenum or biliary tract * biliary obstruction was located at hilum or ihd * patients with uncontrolled infection * pregnancy * no signed informed consent
am-101 in the treatment of acute tinnitus 2

Conditions: Tinnitus

Summary: the purpose of this research study is to test the safety and effectiveness of the study drug, am-101. am-101 is tested for the treatment of tinnitus that started as the result of an injury to the inner ear or due to middle ear inflammation (otitis media). subjects with tinnitus can take part in the study, if their tinnitus started within the last 3 months.

this phase iii study is assessing the drug's safety and is aiming to demonstrate efficacy of repeated intratymanic am-101 injections in the treatment of acute peripheral tinnitus (up to 3 months from onset).

Eligibility criteria:
inclusion criteria: 1. persistent subjective peripheral tinnitus (unilateral or bilateral) following traumatic cochlear injury (acute acoustic trauma, blast trauma, middle ear surgery, inner ear barotrauma, tympanic membrane trauma) or otitis media with onset no longer than 3 months prior to randomization 2. age ≥ 18 years and ≤ 75 years (≥ 14 years and ≤ 75 years at selected sites); 3. negative pregnancy test (woman of childbearing potential); 4. willing and able to use adequate hearing protection, respectively to refrain from engaging in activities or work involving loud noise exposure where sufficient hearing protection is not possible or ensured; 5. willing and able to protect ear canal and middle ear from water exposure as long as tympanic membrane is not fully closed. other protocol-defined inclusion criteria may apply. exclusion criteria: 1. fluctuating tinnitus; 2. intermittent tinnitus; 3. tinnitus resulting from traumatic head or neck injury; 4. presence of chronic tinnitus; 5. meniere's disease, history of endolymphatic hydrops, or history of fluctuating hearing loss; 6. history of repeated idiopathic sudden sensorineural hearing loss or history of acoustic neuroma; 7. ongoing acute or chronic otitis media or otitis externa; 8. other treatment of tinnitus for the study duration; 9. known hypersensitivity, allergy or intolerance to the study medication or any history of severe, abnormal drug reaction; 10. women who are breast-feeding, pregnant or who are planning to become pregnant during the study; 11. women of childbearing potential who are unwilling or unable to practice contraception, such as hormonal contraceptives, double barrier, sexual abstinence or intercourse with a partner who has been vasectomised for at least three months; 12. concurrent participation in another clinical study or participation in another clinical study within 30 days prior to randomization. other protocol-defined exclusion criteria may apply.
elaboration of a pronostic score of changes on wheelchair's seating system

Conditions: Neuromuscular Diseases

Summary: development and validation study of a prognostic score - study of prognostic performance by a prospective longitudinal multicenter cohort spread over 8 centers: 4 for the development cohort and 4 for the validation cohort).

progressive muscle weakness in neuromuscular diseases leads to motor disabilities leading to permanentfull-time wheelchair use. this is the case for infantile spinal muscular atrophy type ii (sma ii), where people are dependent on a permanent sitting position from early childhood, at 2 years of age, or for duchenne muscular dystrophy, when they lose their ability to walk around 10 years without corticosteroid therapy or around 13 years with treatment. these wheelchair users, weakened by the disease, are subject to musculotendinous retractions, osteo-articular stiffness, spinal deformities and pain. in addition, they use the wheelchair on a daily basis, on average 12 hours a day, whose permanent sitting position also conditions the performance of achieving life habits. the analysis of the static and dynamic seated postural installation in the wheelchair makes it possible to avoid harmful consequences on the health and quality of life of users on a daily basis. when performed early enough, regularly and optimally, it also contributes to the prevention of complications. in france, these assessments are carried out by occupational therapists, accompanied by doctors of physical medicine and rehabilitation. the weakness of the literature in this area and the absence of recommendations do not allow the user or any health professional to identify the need and the level of urgency to benefit from a dedicated consultation. faced with this observation, the development of a prognostic score for a change in positioning in the wheelchair, based on a prospective multicenter cohort and its validation on an external prospective cohort, will allow any healthcare professional to guide the user to a necessary positioning consultation. the hypothesis is that this score has discriminating qualities and that it is calibrated to predict a change in the seat of the rf and therefore the need to reassess the seated postural installation.

Eligibility criteria:
inclusion criteria: * male or female over the age of 18 * daily wheelchair user (more than 4 hours per day) * having a neuromuscular disease such as duchenne muscular dystrophy or infantile spinal muscular atrophy type ii * accompanied by an identified medical equipment provider, able to respond to the recommendations of the clinical team * patient informed and having signed consent. exclusion criteria: * person who already has a seat change or fr prescription at the time of inclusion * having undergone surgery less than 1 year ago or a fracture * pregnant or breastfeeding women * patient under guardianship or curatorship.

Keywords: neuromuscular diseases
electroencephalography predictors of repetitive transcranial magnetic stimulation in obsessive-compulsive disorder

Conditions: Obsessive Compulsive Disorder (OCD)

Summary: this study used electroencephalogram (eeg) to predict the efficacy of repetitive transcranial magnetic stimulation (rtms) in patients with obsessive-compulsive disorder.

repetitive transcranial magnetic stimulation (rtms), as a relatively mature non-invasive neuromodulation technology, has been recommended for the treatment of patients with refractory ocd in multinational guidelines. however, due to the treatment setting and the patient's feature, nearly half of the patients have no significant changes after rtms treatment. in order to better predict the outcome of rtms and improve the treatment efficiency, this project intends to look for markers that have a predictive effect at baseline or early treatment. electroencephalogram (eeg) is a cheap and fast method that usually occurs before the symptoms change, thus it is possible to determine whether the patient has responded to the intervention. in this project, the supplementary motor area (sma) is selected as the stimulation target. the individual head magnetic resonance image positioning and navigation and rtms compatible real-time eeg acquisition technology are used to monitor the resting state of eeg and rtms single pulse stimulation and changes in neural networks before and after treatment. this is a preliminary exploration looking for effective predictive indicators of efficacy in eeg and the relationship between eeg and symptoms changes. in order to lay the foundation for further research and guide clinical treatment.

Eligibility criteria:
inclusion criteria: * age\>18 years old; * dsm-5 criteria for ocd; * y-bocs total score \> or = 16 -\>or＝9 yrs education exclusion criteria: * any additional current psychiatric comorbidity, except for obsessive-compulsive personality disorder serious suicide risk; * the inability to receive rtms because of metallic implants, or history of seizures，or history of head injury, or history of neurosurgery; * any major medical disease; * pregnancy or nursing of an infant; * participation in current clinical study; * current use of any investigational drug; * tms/dbs treatment at any point in their lifetime; * history of long-time use of benzodiazepines
mindfulness-based intervention for postnatal depression

Conditions: Postnatal Depression

Summary: postnatal psychopathology have adverse impact on both mothers and infants. few postnatal women with depressive symptoms receive treatment, and pharmacological intervention has not been well accepted due to the medication side-effects. recently, mindfulness-based interventions were found to be beneficial for symptoms in perinatal and antenatal women with depression. these non-pharmacological interventions require less resources and are more feasible for postnatal women to practice at home. to date, no randomized controlled trial has examined mindfulness-based intervention program as a treatment for women with postnatal depression. the proposed randomized controlled trial aims to examine the effects of an 8-week mindfulness-based intervention program on symptom and cognition for postnatal females with depressive symptoms. a total of 70 postnatal women with depressive symptoms will be recruited from the psychiatric outpatient clinics in hong kong, and will be randomized into two groups: 1) an 8-week mindfulness-based intervention program (n=35); 2) a booklet-based psychoeducation control group (n=35). all participants will be assessed for depression, anxiety, stress, cognition, role functioning, quality of life, sleep quality and mindfulness ability at the baseline, 8 weeks, and 3 months after intervention. the intervention sessions will be held once weekly lasting 90 minutes for 8 weeks. the investigators primarily hypothesize that participants in the mindfulness-based intervention group will improve depressive symptom after 8 weeks compared with the control group. secondary, the mindfulness-based intervention will improve anxiety, stress, cognitive functions, sleep quality, quality of life and mindfulness ability.


Eligibility criteria:
inclusion criteria: * females aged from 18 and above * the edinburgh postnatal depression scale cut-off score of \>=9 * at least 6 weeks, and up to one and half years after childbirth * cantonese-speaking chinese exclusion criteria: * severe physical illness (myocardial infarction, hypertension, fracture, spinal problems in which yoga may be contraindicated), and seizure disorders. * comorbid substance dependence * women with psychotic depression, severe eating disorders, actively suicidal or obsessive-compulsive disorders * known pregnancy * a history of bipolar disorder, schizophrenia, brain trauma or organic brain disease, mental retardation, or antisocial personality disorder * practice of mindfulness (in forms of tai chi, qi gong or yoga etc.) more than twice a week during the previous three months.
medication list in and out of hospital

Conditions: Febrile Illness; Acute Cardiovascular Disease; Acute Respiratory Disease

Summary: 30 patients acute hospitalized to medical ward and their medication records are examined. it is to be recorded how the investigators find information about medicine use by the reception when they do not follow the patient. the record of the changes made during hospital stay is examined, whether they are justified in the discharge summaries and whether they are described in the medical list. after a month is to find out if the gp has recorded or possibly rejected changes to medication made in hospital.

furthermore is to be recorded how the investigators find information about medicine use by the reception when they do not follow the patient and how long it takes to find the right medicine list. the record of the changes made during hospital stay is examined, whether they are justified in the discharge summaries and whether they are described in the medical list. after a month is to find out if the gp has recorded or possibly rejected changes to medication made in hospital. this shall be recorded in the review of 30 patient with a focus on their medication list and follow them from admission to a month after discharge. medicine list in discharge summaries will be compared with medication written in journal during hospital stay and changes described in the text summaries and medication lists should be checked against the same journal. medicine list in the municipality one month after discharge shall be compared with discharge summaries and it will be mapped on the gp register, modified and considered if they are valid. hypothesis: medicine list is missing at admission by \> 50% of patients admitted acutely into hospital. medicine list at admission, when available, is often incomplete. when the medication list is not available at admission, its content is often incomplete even after the staff at reception have tried to gather information from different sources. changes of regular medication is not always present in the discharge summaries. the changes are not always justified in the discharge summaries. the gp often do not correct the medication list in the journal to the discharge summary. the gp does not give the patient an updated printout of the list at the first medical consultation after admission.

Eligibility criteria:
inclusion criteria: * acute hospitalized to medical ward * using three or more drugs, prescription only exclusion criteria: * not been able to give consent, if too severely ill or not mentally capable

Keywords: medication list changes in medication prescription medication
staphylokinase and abo group phenotype: new players in staphylococcus aureus implant-associated infections development

Conditions: Staphylococcal Infection

Summary: the purpose of this study is to identify bacterial and/or clinical features involved in the pathogenesis of staphylococcus aureus implant-associated infections (iai). materials \& methods: in total, 57 iai s. aureus and 31 nasal carriage (nc) s. aureus isolates were studied. staphylococcus aureus genetic background was obtained by microarray analysis. multilocus sequence typing was performed to determine clonal complexes (cc). biofilm production was investigated by resazurin and crystal violet methods


Eligibility criteria:
inclusion criteria: * infected patients with s. aureus iai infection * noninfected patients screened for s. aureus nasal colonization at the orthopedic consultation ward exclusion criteria: * minor

Keywords: biofilm staphylokinase staphylococcus aureus microarrays bone binding sialoprotein bone and joint infection blood group
effectiveness of cane in osteoarthritis (oa) patients

Conditions: Knee Osteoarthritis

Summary: sixty four participants were enrolled in a randomized, controlled clinical trial to evaluate the effectiveness of daily cane use on pain, function, quality of life and energy consumption during the gait in patients with knee osteoarthritis.

treatment, randomized, single blind, parallel assignment, efficacy study

Eligibility criteria:
inclusion criteria: * primary knee osteoarthritis (acr criteria) * vas for knee pain between 3 and 7 * no changes the nsaid intake or physical activity in the previous 3 months exclusion criteria: * symptomatic heart or pulmonary disease * severe systemic disease * other symptomatic disease in the lower limb or in the upper limb that will carry the cane * joint injection in the previous 3 months * pt in the previous 3 months * previously cane use * start regular physical activity in the last month

Keywords: knee osteoarthritis daily cane use pain function quality of life energy consumption during the gait
non-invasive left ventricle contractility dp/dt as prognostic marker in chest unit patients

Conditions: Chest Pain

Summary: ischemic heart disease is a major public health problem with high mortality rate despite the progress in management and the resources mobilized. the idea is that myocardial ischemia is generally associated with left ventricular dysfunction and, consequently, a possible alteration of the dp/dt index. as dp/dt could be assessed non-invasively by plethysmographic method, it is interesting to investigate its prognostic performance in patients with indifferentiate chest pain.

ischemic heart disease remains a major public health problem. despite all the advances in the prognostic approach to ischemic heart disease, the risk of occurrence of major cardiovascular events is not negligible. several scores have been proposed for chest pain stratification risk, the most widely used are the timi and the grace scores. the dp/dt max is therefore an excellent index of contractility, corresponding to the maximum level of tension developed by an isolated cardiac muscle during the isovolumic contraction phase. the investigator theorized that a less value of dp/dt would be associated with more major cardiovascular events (mace), because ischemia reduces myocardial contractility. the current study describes non-invasive plethysmographic dp/dt changes, which could be used as a prognostic marker in patients presenting at the emergency department with acute chest pain.

Eligibility criteria:
inclusion criteria: * age over 18 years old, * acute chest pain exclusion criteria: * traumatic chest pain, * hemodynamic instability; * arrhythmias; * holders of a pacemaker; * stemi

Keywords: chest pain, myocardial ischemia, acute myocardial dysfunction, plethysmography, non invasive dp/dt.