Kornimate/medical-research-clean huggingface dataset:
bexarotene with narrow-band uvb for psoriasis

Conditions: Psoriasis

Summary: to determine if bexarotene gel with nbuvb phototherapy is more effective than placebo plus nbuvb for moderate to severe plaque-type psoriasis.

subjects will be applying active gel or placebo to target lesions to each side of the body in a blinded manner. they will start at three times a week and increase to daily or even twice a day regimen if tolerated. after 2 weeks of application, nbuvb will be added to treatment regimen (whole body, three times a week). total study time is 10 weeks.

Eligibility criteria:
inclusion criteria * patient must be a male or female aged 18 years or older * patient must have moderate to severe psoriasis vulgaris of at least 3% body surface area involvement * patient must have failed prior topical therapy * patient must be willing to minimize sun exposure, to use sun blockers if deemed necessary by the investigator and to avoid use of tanning booths or other ultraviolet (uv) light sources * women of childbearing potential must have a negative urine ß-hcg pregnancy test with a sensitivity of at least 50 miu/ml within seven days prior to starting of study gels and repeated every four weeks while patient remains on the study gels. all females of childbearing potential must agree to use 2 effective contraceptive methods or remain sexually abstinent one month prior to initiation of study drug, during the entire study period, and for one month after the last application of targretin® gel 1%. acceptable methods of birth control include: condoms with spermicide; diaphragm with spermicide; cervical cap with spermicide; spermicidal sponge; intrauterine device (iud), oral contraceptives, depo-provera; contraceptive implants; vasectomy; or abstinence. * male patients must agree to use condoms with sexual partners of childbearing potential during the entire period of treatment and for at least one month after treatment is discontinued. * patients who are not sexually active and are not using contraception, must agree to use an approved method of contraception (as described above) should they become sexually active during the study exclusion criteria * failure to understand the consent form * inability to comply with protocol requirements * pregnancy * inadequate birth control method * lactation * contraindication to use of topical retinoids * concomitant psoriasis therapies except for emollients and otc shampoos * systemic psoriasis therapies, systemic vitamin a in doses \> 15,000iu/day, puva, (psoralen plus ultraviolet a irradiation), uvb, topical psoriasis therapies (other than emollients and otc shampoos), other retinoid class drugs or investigational drugs within the past 1 month * current skin cancer * history of previous melanoma * history of skin sensitizing diseases (such as sle) * concurrent medical illness that would make participation in this clinical trial ill-advised * patient unwilling or unable to avoid prolonged exposure to the sun or other uv light sources

Keywords: psoriasis bexarotene narrow band uvb
study assessing the interest of indocyanine green fluorescence imaging with radioisotope method for sentinel lymph node biopsy in patients with breast cancer

Conditions: Breast Neoplasms

Summary: the sentinel node has a fundamental role in the management of early breast cancer. currently, the double detection of blue and radioisotope is recommended. a radioactive material requires the presence of a nuclear medicine department and the approval of health authorities. in many centers, this technique is not available. the use of blue is easier to implement technique. however, allergic reactions and prolonged breast tattoo led many teams to stop the practice. so in common practice, many center use a single method. however, with a single detection, the risk of false negatives and the identification failure rate increased to a significant extent and the number of sentinel lymph node detected and removed is not enough. under these conditions, find another method of detection seems crucial. according to the literature, the fluorescence method (icg) is a technique that seems safe and reliable. the investigators therefore propose a prospective, randomized study to investigate the interest of fluorescence associated with the isotopic method.


Eligibility criteria:
inclusion criteria: * histologically proved infiltrating breast cancer (ductal, lobular carcinoma...) or a carcinoma in-situ with an elevated risk of micro-invasion. (high grade with necrosis, radiologically evaluated size more than 40mm, or immediate mastectomy...) * unifocal or multifocal but in same quarter * size \< 5cm clinically palpable or not * clinically or ultrasound axillary n0 * isotopic sentinel node detection * adult patient * signed informed consent by patient or legally responsable authority * patient registered to a social security system * no surgical contra-indication exclusion criteria: * mammary carcinoma recurrence * previous same side mammary reduction * previous lumpectomy * contra-indication to surgery * pregnant or breast feeding patient * denial of participation

Keywords: sentinel lymph node indocyanine green fluorescence method radioisotope conventional method breast cancer
cholesterol-lowering effects of plant stanol ester

Conditions: Dyslipidemias; Hypercholesterolemia; Hyperlipidemias

Summary: efficacy of plant stanols as esters on ldl-cholesterol reduction is well documented. ldl-cholesterol lowering efficacy of the ingredient administered in a smoothie is less well known.


Eligibility criteria:
inclusion criteria: * total cholesterol concentration ≥ 200 mg/dl and \< 300 mg/dl, and or ldl-c concentration ≥ 130 mg/dl and \< 180 mg/dl * were willing to consume control or plant stanol ester smoothie drinks two bottles per day immediately after a meal for four weeks, * reachable by phone * willing to declare written informed consent * agreed in accordance with data protective stipulations and readiness to participate in the trial and to adhere to the study conditions. exclusion criteria: * pregnant women * obese * diabetic subjects or subjects with random plasma glucose concentration \> 200 mg/dl * hyperthyroidism, a history of metabolic, endocrine and kidney disorders * acute or chronic severe diseases possibly interfering with the evaluation of the outcome of the clinical trial (such as aids, tumor diseases, malignant hypertension, cardiac insufficiency according to nyha iii-iv) * taking lipid-lowering medication or other medications likely to affect lipid metabolism
the effect of whole-body vibration training

Conditions: Biomarkers

Summary: the whole-body vibration programme employed in this study partly improved the biomarkers and health beliefs of the prefrail community-dwelling older adults.

the experimental group participated in a 12-week whole-body vibration training that conducted 3 times per week, with 5-min continuous vibration at 12-hz frequency and 3-mm amplitude each time

Eligibility criteria:
inclusion criteria: * age of 65 years or older and living in a community * full consciousness and able to communicate verbally * no severe cognitive disorder exclusion criteria: * impaired mobility after recent surgery * major illness such as cancer * severe hearing impairment and inability to fully understand and follow instructions

Keywords: older adults community frailty biomarkers health belief prefrailty quasi-experimental design whole-body vibration training
a dog-assisted therapy to reduce burnout among professionals working in a school for special education

Conditions: Occupational Groups; Work Related Stress

Summary: this randomized controlled trial aims to evaluate the effects of an 8-week program consisting of dog-assisted therapy on the work engagement, burnout, pain, and quality of life among professionals working in a school for special education. a total of 30 participants will be involved in the program, which will be comprised of eight 50-min sessions conducted once a week. the hypothesis of the researchers in this study is that this program will achieve a reduction in burnout levels in workers, as well as an improvement in engagement and quality of life.

animal-assisted interventions have shown numerous benefits in different populations including children with cerebral palsy or autism spectrum disorder, people with chronic pain, older adults, or people in prison. recently, different initiatives have been carried out focused on improving the work environment, especially among professionals in clinical settings and obtaining benefits in mood, as well as a reduction in the levels of stress and burnout of employees. in addition, it has also been observed that these animals in the workplace can produce an improvement in health, productivity or job satisfaction. the presence of stress or anxiety among professionals working in special education schools has been previously reported and could increase burnout and reduce the engagement and health-related quality of life of these workers. therefore, the current randomized controlled trial aims to evaluate the effects of an 8-week program consisting of dog-assisted therapy on the work engagement, burnout, pain, and quality of life among professionals working in a school for special education. a total of 30 participants will be involved in the program, which will be comprised of eight 50-min sessions conducted once a week. the hypothesis of the researchers is that this program will achieve a reduction in burnout levels in workers, as well as an improvement in engagement and quality of life.

Eligibility criteria:
inclusion criteria: * be aged \>18 years * be workers in a school for special education * work in direct contact with children (teachers, physiotherapists, etc.) exclusion criteria: * people with dog-allergy * people with dog phobia * people with a history of impulsive animal aggression

Keywords: dog-assisted burnout quality of life work engagement human-animal interaction animal-assisted
exploration of pupil dilation in horner's patients taking flomax

Conditions: Horner Syndrome

Summary: this study is evaluating the pupil dilation of horner's patients who have ever taken an alpha blocker such as tamsulosin. patients will undergo eye dilation as would occur at a yearly eye examination, but their pupil dilation measurements will be recorded.

this study will enroll 10 participants who have a unilateral horner's syndrome and have a history of taking an alpha blocker such as tamsulosin. participants will be recruited based on those two enrollment criteria, and after consenting they will undergo pupil dilation with 10% phenylephrine. once fully dilated the pupil size will be measured. pupil dilation size of the eye affected by the horner's syndrome will be compared to the eye not affected by horner's. primary study outcome is the comparative dilation size of the horner's affected eye to the non affected eye in all subjects.

Eligibility criteria:
inclusion criteria: 1. horner's syndrome 2. history of taking an alpha blocker (tamsulosin/ terazosin/doxazosin/alfuzosin/silodosin) medication exclusion criteria: 1. subjects with untreated hypertension 2. subjects with thyrotoxicosis 3. pregnant women 4. prisoners 5. inability to consent 6. subjects with anatomical narrow angles who have never had a dilated exam

Keywords: alpha blockers tamsulosin
manual diaphragmatic release on ventilatory functions in women with rheumatoid arthritis

Conditions: Rheumatic Arthritis; Lung Function

Summary: evaluate the effect of manual diaphragmatic release on ventilatory functions in women with rheumatoid arthritis

sixty women with rheumatoid arthritis will be sourced from the rheumatology outpatient clinic at tanta university hospitals in egypt, with referrals from rheumatologists. patients will be randomly assigned into two groups. the study group will include 30 women participating in manual diaphragmatic release plus aerobic training for 12 weeks while the control group will include 30 women participating in aerobic training only for 12 weeks. at baseline and poststudy, the following outcomes will be assessed: 1. ventilatory functions (forced vital capacity and total lung capacity). 2. functional capacity using modified bruce treadmill incremental exercise test (maximal oxygen consumption estimation). 3. quality of life (short form health survey).

Eligibility criteria:
inclusion criteria: * all women will have rheumatoid arthritis for more than 2 years with low-to-moderate disease activity. * normal to mildly restrictive lung pattern. * their ages will be ranged from 40 to 60 years old. * their body mass index will be less than 30 kg/m2. exclusion criteria: * chronic chest diseases. * recent parenteral steroid administration. * cardiovascular disorders (coronary heart disease, heart failure, cardiac arrhythmia, peripheral arterial disease, uncontrolled hypertension). * smokers. * joint surgery (in the preceding 6 months). * musculoskeletal/ neurological limitations to exercise. * pregnancy.
dosing flexibility study of oral testosterone undecanoate (tu, lpcn 1021)

Conditions: Hypogonadism, Male

Summary: this is a multicenter, open-label, one treatment study evaluating the efficacy of lpcn 1021 in adult hypogonadal male subjects.


Eligibility criteria:
inclusion criteria: 1. serum total t below 300 ng/dl based on 2 consecutive blood samples obtained between 6 and 10 am, on two separate days at approximately the same time of day, following an appropriate washout of current androgen replacement therapy. 2. subjects should be diagnosed to be primary (congenital or acquired) or secondary hypogonadal (congenital or acquired). 3. naïve to androgen replacement or has discontinued current treatment and completed adequate washout of prior androgen therapy. washout must be completed prior to collection of baseline serum t samples to determine study eligibility. exclusion criteria: 1. history of significant sensitivity or allergy to androgens, or product excipients. 2. clinically significant findings in the pre-study examinations including abnormal breast examination requiring follow-up. 3. abnormal prostate digital rectal examination (dre) with palpable nodule(s). 4. subjects with symptoms of moderate to severe benign prostatic hyperplasia. 5. clinically significant abnormal laboratory value, in the opinion of the investigator, in serum chemistry, hematology, or urinalysis 6. positive test result for hepatitis a virus immunoglobulin m (hav-igm), hepatitis b surface antigen (hbsag) or hepatitis c virus antibody (hcv ab) or human immunodeficiency virus antibodies (hiv ab). 7. history of gastric surgery, cholecystectomy, vagotomy, bowel resection or any surgical procedure that might interfere with gastrointestinal motility, ph or absorption. 8. history of any clinically significant illness, infection, or surgical procedure within 1 month prior to study drug administration. 9. history of stroke or myocardial infarction within the past 5 years. 10. history of or current or suspected prostate or breast cancer. 11. history of untreated and severe obstructive sleep apnea. 12. history of long qt syndrome (qtc \> 450) or unexplained sudden death in a first degree relative (parent, sibling, or child).
effect of low-volume hit vs. mic exercise in individuals with increased bmi

Conditions: Overweight and Obesity

Summary: to compare the effect of low volume high intensity training and moderate intensity continuous exercise on rate pressure product (rpp) and functional capacity. limited literature available on effectiveness of low-volume hiit in comparison of other aerobic interventions in obese individuals. in our community, people are sedentary and not involved in routine exercise because of increased weight, so low volume hiit would be safe and convenient for such individuals to perform. there is also limited studies available on female gender so both genders are included in this study.

some recent studies suggest that the rising interest for the potential of high- intensity interval training (hiit) to enhance the metabolic health in overweight adults. hiit has also been found to induce comparatively fast enhancements in overall-body aerobic capacity and muscle mitochondrial markers in individuals with overweight. the main advantage of hiit is that low-volume hiit protocols can involve a shorter time as compared with mict, and time limitations have been recognized as a generally reported hurdle to daily exercise involvement. latest studies propose that's when compared to moderate intensity continuous training (mict), hiit has been shown to produce similar and sometimes better improvements in results such as cardiorespiratory fitness in spite of often demanding a smaller amount of time commitment and lesser energy expenditure. on the other hand, low volume hiit is still undecided whether this form of physical training is superior, equivalent or inferior to more outdated forms of exercise training such as mict for the management cardio metabolic health.

Eligibility criteria:
inclusion criteria: * body mass index 23-29.9 kg/m 2 (overweight-type i obese) * able to do exercise (par-q) exclusion criteria: * history of chronic diseases and medication use * considerable mental or physical disability, neurological or musculoskeletal problems * severe personality disorders or drug addiction. * pregnant females

Keywords: low volume high intensity training moderate intensity continous exercise rate pressure product functional capacity increased bmi
safety and efficacy of fluoroscopy-free technique during retrograde intrarenal surgery for renal stones

Conditions: Kidney Calculi; Radiation Exposure; Retrograde Intrarenal Surgery

Summary: aiming to reduce radiation exposure to patients and physicians, the investigators conduct this study protocol to evaluate the possibility of performing retrograde intrarenal surgery (rirs) under direct visualization without fluoroscopy. the investigators will prospectively evaluate the outcome of fluoroscopy-free rirs for renal stones in comparison with the standard technique. the investigators expected that the fluoroscopy-free technique has high safety and efficacy even in complicated cases.

with improved flexible urs instrumentation and lithotripsy technology, retrograde intrarenal surgery (rirs) became an alternative and excellent option for renal stones. fluoroscopy imaging may be necessary during various steps of rirs, such as insertion of a guidewire and stent, access sheath insertion, detection of stone location and size, and assessment of collecting system anatomy. in an effort to decrease radiation exposure, several studies were conducted to evaluate the possibility of performing rirs under direct visualization without fluoroscopy. most studies concluded that fluoroscopy-free rirs is a feasible, effective, and safe technique. the reported stone-free rate ranged from 83.8% to 95.7%. no major complications were observed. despite the reported high safety and efficacy of the fluoroscopy-free rirs technique, most of the studies were retrospective and included only uncomplicated cases, and none of the studies address its results against control. in the present study, the investigators will prospectively evaluate the efficacy and safety of fluoroscopy-free rirs for renal stones in comparison with fluoroscopy-guided technique as standard control. the study will include all patients with renal stones amenable to rirs. the investigators expected that the fluoroscopy-free technique can deal with large stones and complex situations with high safety and success rate. the study hypothesis is that "the fluoroscopy-free technique has efficacy and safety similar to the fluoroscopy-guided technique". the investigators also aim to determine the patients and surgical characteristics impacting the need for fluoroscopy. the intra-operative fluoroscopy imaging is expected to be necessary during rirs, especially in complicated cases. in the fluoroscopic-free group, the fluoroscopic equipment will be available in the operating room and will be used if needed.

Eligibility criteria:
inclusion criteria: * renal stone. * stone size: ≥10 mm. exclusion criteria: * partial and complete staghorn stones. * pregnant women. * morbid obesity. * uncorrectable coagulation disorders. * active urinary tract infection (uti). * stone in a calyceal diverticulum. * urinary tract obstruction distal to the stone. * concomitant pathology that needs intervention in the same setting.
evaluating safety and efficacy of umbulizer in patients requiring intermittent positive pressure ventilation

Conditions: Respiratory Failure; Respiratory Insufficiency; Respiratory Arrest

Summary: randomized, control crossover study comparing umbulizer's efficacy to traditional mechanical ventilators

mechanical ventilators cost tens of thousands of dollars, rendering them difficult for low and middle income countries to procure. given chronic shortages of these devices in places like pakistan, patients are often ventilated manually with ambu bags for hours or days. this method is not suitable for long term ventilation and is extremely life threatening. umbulizer seeks to reduce preventable deaths due to ventilator scarcity by providing a reliable alternative. the device is accurate, low-cost, and portable, and is an ideal solution for treating patients with respiratory diseases in low-resource settings. the primary objective of this study is to test efficacy and determine non-inferiority of this device in comparison to ventilation provided by traditional ventilators. secondary objectives of this study include: 1. testing safety of the device for use over a predetermined period of time 2. evaluating patient comfort during ventilation with this device 3. assessing ease of use of this device for doctors and medical staff

Eligibility criteria:
inclusion criteria: 1) patients needing mechanical ventilation exclusion criteria: 1. patients with significant airway resistance (i.e. severe chronic obstructive pulmonary disease or asthma) where clinical investigator is concerned about gas trapping or barotrauma 2. patients with very low lung compliance (i.e. severe acute respiratory distress syndrome or restrictive disease) where clinical investigator is concerned about problems delivering sufficient tidal volume or end expiratory pressure 3. patients who experienced a myocardial infarction within the last 6 weeks 4. patients who are determined by a clinical investigator to be too hemodynamically unstable to be enrolled

Keywords: respiratory disease low resource settings mechanical ventilation ventilator performance comparative study patient safety ease of use