Kornimate/medical-research-clean huggingface dataset:
oncolytic virus plus anti-pd1 and chemotherapy as preoperative therapy for patients with brpc/lapc

Conditions: Pancreatic Cancer

Summary: the aim of this single center, single arm and prospective study is to explore the safety and efficacy of oncolytic virus plus anti-pd1 and chemotherapy as preoperative therapy for patients with borderline resectable and locally advanced pancreatic cancer


Eligibility criteria:
inclusion criteria: - age ≥18 years and age ≤75 years. ecog score 0-1. patients with borderline resectable and locally advanced pancreatic cancer adequate bone marrow and organ function: patients of childbearing potential must take appropriate precautions prior to enrollment and during the study. signed informed consent. ability to comply with the study protocol and follow-up. exclusion criteria: 1. received antitumor chemotherapy, radiation therapy, and immunotherapy prior to first treatment. 2. patients with comorbid severe pancreatic portal hypertension, which may cause a higher risk of bleeding with subsequent injection therapy; 3. patients with prior or concomitant history of other tumors (except basal cell carcinoma of the skin, cervical cancer in situ). 4. serious uncontrolled medical conditions that may interfere with the subject's ability to receive treatment as specified in the protocol, including, but not limited to, positive hiv test, active tuberculosis, and dna copy number of hbv \>103/ml; 5. uncontrollable comorbidities, including, but not limited to, active bacterial, viral, tuberculosis, or fungal infection, symptomatic congestive heart failure, unstable angina, and cardiac arrhythmia. 6. patients with autoimmune disease or immunodeficiency treated with immunosuppressive drugs; 7. pregnant or lactating women; 8. those who may be allergic to the study drug or any of its excipients; 9. preoperative ultrasound evaluation of patients with small tumor size, location near or behind major blood vessels, and various other factors that may result in a low success rate of intra-tumoral viral injection under ultrasound and a high rate of post-injection complications; 10. substance abuse or those who are unable to undergo immunization or lysosomal viral therapy due to clinical, psychological, or social factors. 11. any uncertainty that affects patient safety or compliance.

Keywords: pancreatic cancer oncolytic virus immunotherapy preoperative therapy
neuroregenerative potential of intravenous g-csf and autologous peripheral blood stem cells

Conditions: Neurodegeneration; G-CSF; Peripheral Blood Mononuclear Cells; Cerebral Palsy

Summary: the current study describes a randomized, double-blind, cross-over study of intravenous g-csf followed by infusion with autologous mobilized peripheral blood mononuclear cells (mpbmcs) in children with cerebral palsy (cp) to determine the safety and feasibility of the procedure, as well as the potential efficacy for improving neurological impairment.

we hypothesized that mobilized peripheral blood mononuclear cells (mpbmcs) would be a better source of cell therapy for children with cp, if these cells had a similar neuroregenerative potential to bone marrow/cord blood mononuclear cells (mncs). multipotent precursor cells exist in peripheral blood, and a fraction of elutriated blood cells from normal individuals contains mncs that have the potential to be mscs. there are several advantages to using mpbmcs for cell therapy in children with cp: the g-csf that is used to mpbmcs has neuroregenerative potential; the collection and fractionation of stem cells can be repeated; and, the therapy is suitable for most children with cp.

Eligibility criteria:
inclusion criteria: * non severe type of cerebral palsy * evidences of abnormal mri findings such as periventricular leukomalacia * collected mobilized peripheral blood mononuclear cell counts \> 1×10\^8/kg or cd34+ cell counts \> 1×10\^6/kg * consent form exclusion criteria: * previous trials of autologous cord blood infusion or erythropoietin/g-csf * chromosomal abnormalities

Keywords: neuroregeneration g-csf peripheral blood mononuclear cells cerebral palsy
trial of famotidine & n-acetyl cysteine for outpatients with covid-19

Conditions: Covid19

Summary: the purpose of this trial is to assess the safety and toxicity profile of the combination of famotidine and oral n-acetyl cysteine in adult outpatients with newly diagnosed sars-cov-2 infection.

this is a phase i trial enrolling subjects with newly diagnosed sars-cov-2 infection who do not require hospitalization. exclusion criteria have been written to exclude patients who would be expected to have increased risk from either medication alone. subjects will be assigned a dose combination of famotidine and n-acetyl cysteine. in addition to assessing the safety and toxicities profiles of the combination of drugs we will be measuring certain endpoints to assess possible efficacy. these endpoint include the following: rates of hospitalization; time to complete remission of symptoms, e.g, fever, respiratory symptoms, etc.; severity of symptoms with validated survey instruments; cytokine values in serum and urine; and markers of inflammation and oxidative stress.

Eligibility criteria:
inclusion criteria: * age \> 18 * performance of a sars-cov-2 test within 1 day of enrollment, n.b., must be positive to proceed to treatment phase of the trial exclusion criteria: * all patients under 18 * known allergy to n-acetyl cysteine * known allergy to famotidine or other h2-receptor antagonists * pregnant or nursing mothers * laboratory evidence or history of renal impairment (egfr \< 30 ml/min/1.73 m2) * taking h2-receptor antagonists, hydroxychloroquine or chloroquine. * patient has been admitted to the hospital prior to study enrollment

Keywords: outpatient famotidine n-acetyl cysteine
efficacy and safety study of mavorixafor in participants with warts, hypogammaglobulinemia, infections, and myelokathexis (whim) syndrome

Conditions: WHIM Syndrome

Summary: this study has a double-blind, randomized placebo-controlled period and an open-label period. the primary objective of the randomized placebo-controlled period is to demonstrate the efficacy of mavorixafor in participants with whim syndrome as assessed by increasing levels of circulating neutrophils compared with placebo, and relative to a clinically meaningful threshold. the primary objective of the open-label period is to evaluate the safety and tolerability of mavorixafor in participants with whim syndrome. participants are allowed to continue treatment in the open-label period, if regionally applicable, until mavorixafor becomes commercially available, or until the study is terminated by the sponsor.


Eligibility criteria:
inclusion criteria for the randomized placebo-controlled period : * have signed the current approved informed consent form. participants under 18 years of age (in the netherlands and other applicable regions, participants under 16 years of age) will sign an approved informed assent form and must also have a signed parental/legal guardian consent. * have a genotype-confirmed mutation of chemokine (c-x-c motif) receptor 4 (cxcr4) consistent with whim phenotype. * agree to use a highly effective form of contraception. * be willing and able to comply with the protocol. * have confirmed anc ≤400 cells/µl during screening, obtained while participant has no clinical evidence of infection. inclusion criteria for the open-label period: * completed the randomized period; or * granted early release from the randomized period. exclusion criteria: * has known systemic hypersensitivity to the mavorixafor drug substance, its inactive ingredients, or the placebo. * is pregnant or breastfeeding. * has any medical or personal condition, which in the opinion of the investigator may potentially compromise the safety or compliance of the participant or may preclude the participant's successful completion of the clinical study.
hematopoetic stem cell transplant and physical function

Conditions: Cancer; Walking

Summary: this study will determine if a structured walking intervention will help maintain or improve physical activity levels, physical function and quality of life in hematopoietic stem cell transplant patients.

the researchers will quantify the decline in physical function of hsct patients using valid and reliable tests aimed to mimic activities of daily living, quantify cardiovascular health, and quantify muscle power declines. also, patients will undergo a walking program during their hospitalization, which is designed to increase physical activity levels and maintain and improve physical function and quality of life. additionally, using valid and reliable questionnaires, the researchers will gauge perception of exercise, quantify current exercise levels, determine preference of exercise programs and counseling, and measure differences in quality of life before and after hsct treatment.

Eligibility criteria:
inclusion criteria: * be between 40 and 80 years of age * willing and able to provide written informed consent in english * ability to comprehend the purpose of the study * be scheduled to receive an autologous or allogeneic hematopoietic stem cell transplant at sylvester comprehensive cancer center * have an expected hospital stay of at least 2 weeks * not currently be participating in an exercise training program exclusion criteria: * dementia, altered mental status, or psychiatric condition * received erythropoiesis-stimulating proteins within 4 weeks prior to enrollment * comorbid conditions that would contraindicate exercise testing * undergoing concurrent non-transplant-related chemotherapy or radiation

Keywords: cancer exercise physical function
longitudinal description of hemorrhoidal pathology

Conditions: Hemorrhoids

Summary: hemorrhoidal disease is a common cause of gastroenterology visits. in the united states, it is considered the 3rd most common gastrointestinal diagnosis with nearly 4 million scheduled or emergency visits. in france, self-reported questionnaires estimate that one person in five has suffered at least one hemorrhoidal attack in the past year.

hemorrhoidal disease significantly alters the quality of life, can be life threatening in case of heavy bleeding and has a significant economic impact. however, there are still many unknowns regarding the different types of hemorrhoidal disease, its symptoms, its natural history, its etiology, its triggering and promoting factors, the associated pathologies, the therapeutic indications, etc. in addition, the therapeutic management is not consensual, especially since the therapeutic arsenal is constantly expanding over the last 20 years with the advent of minimally invasive surgical techniques. the aim of the work is to answer some of these questions on the basis of a prospective cohort of patients.

Eligibility criteria:
inclusion criteria: * patient whose age is ≥ 18 years * consecutive patients consulting for hemorrhoidal disease at the proctology department of the groupe hospitalier paris saint-joseph (ghpsj) between january 1, 2020 and april 30, 2020 * french-speaking patient exclusion criteria: * patient objecting to participation in the study * patient under guardianship or curatorship * patient deprived of liberty * patient under court protection
efficiency of the imaging strategy for the management of pneumonia

Conditions: Pneumonia

Summary: for patients with suspected pneumonia presenting to the emergency room, the imaging strategy most often involves a frontal and lateral chest x-ray despite poor diagnostic input. indeed, the radiography is not very sensitive and specific for the diagnosis of pneumopathy compared to the scanner. however, the scanner remains the gold standard, the major constraint of which concerns the irradiation to which the patient is exposed. the new scanners allow ultra-low-dose scans with better sensitivity than standard radiography with an equivalent dose of radiation. in addition, the ultra-low-dose scanner helps prevent diagnostic errors and unintended treatments. a low-dose ct scan for suspected pneumonia has been possible in the strasbourg emergency department since march 2019. the investigators therefore hypothesize that a diagnostic strategy involving the performance of a low dose ct scan in the event of suspicion of pneumopathy in the emergency room makes it possible to improve the adequacy of the diagnosis made by the initial imaging examination and the diagnosis on discharge from hospitalization, to reduce respiratory or hemodynamic complications and to reduce the prescription of antibiotic therapy that is not suitable for the patient. course of the imaging result validated by a panel of emergency physicians and infectious disease specialists based on medical records in accordance with the recommendations.


Eligibility criteria:
inclusion criteria: * major subject (≥18 years old) * emergency consultant subject with a final diagnosis of pneumonia, diagnostic code j18 and j15 with imaging: standard radiography or low dose scanner from 03/01/2019 to 02/29/2020 * subject not having expressed their opposition, after information, to the reuse of their data for the purposes of this research exclusion criteria: * subject having expressed opposition to participating in the study * absence of emergency imaging * subject under guardianship or guardianship * subject under safeguard of justice

Keywords: pneumonia emergency imaging strategy pneumopathy hemodynamic complications antibiotic therapy
how traditional chinese medicine exercise improves parkinson disease

Conditions: Parkinson Disease

Summary: the goal of this clinical trial is to explore the impact of simple gymnastics training on limb motor function and mental health in parkinson's patients in the community (≥60 year old) with swallowing disorders. it primarily aims to address two key aspects: 1) the prevalence of parkinson's diseases among community-dwelling elderly individuals, and 2) the effects of simple gymnastics training on limb motor function and mental health in community-dwelling parkinson's patients. all patients are required to undergo a continuous three-week (21 days) simple gymnastics training, with weekends off and training conducted only on weekdays. the training will be conducted two sessions per day, lasting 30 minutes each.

in the early stages of parkinson's disease, many patients do not seek medical attention. the goal of this clinical trial is to explore the impact of simple gymnastics training on limb motor function and mental health in parkinson's patients in the community (≥60 year old) with swallowing disorders. it primarily aims to address two key aspects: 1) the prevalence of parkinson's diseases among community-dwelling elderly individuals, and 2) the effects of simple gymnastics training on limb motor function and mental health in community-dwelling parkinson's patients. all patients are required to undergo a continuous three-week (21 days) simple gymnastics training, with weekends off and training conducted only on weekdays. the training will be conducted two sessions per day, lasting 30 minutes each.

Eligibility criteria:
inclusion criteria: * age \>60 years. * meeting the diagnostic criteria for parkinson's disease developed by the neurology branch of the chinese medical association in 2006. exclusion criteria: * complicated with cognitive impairment or consciousness dysfunction. * simultaneously suffering from severe liver, kidney failure, tumors, or hematological diseases. * complicated with severe liver and kidney failure, tumors, or hematological disorders.
fast: clinical feasibility

Conditions: Femur Fracture

Summary: this study evaluates the clinical ease of use of the femoral antegrade starting tool (fast).

the investigators will recruit 10 patients at sunnybrook health sciences centre that are scheduled to receive femoral antegrade intramedullary nailing to treat a femur fracture. this study evaluates the clinical ease of use of the femoral antegrade starting tool (fast) device, and the surgical workflow during entry point selection and guidewire alignment for intramedullary nailing of femoral fractures. it is hypothesized that the usage of the tool will reduce surgery time and number of images required.

Eligibility criteria:
inclusion criteria: * patients with a femoral shaft fracture * undergoing anterograde intramedullary nailing procedure exclusion criteria: * femoral head or neck fractures
retrieval of hepatitis c patients lost to follow-up

Conditions: Hepatitis C

Summary: the main purpose of the study is to compare the efficacy of two strategies aimed to rescue patients lost to follow-up with active infection or with positive hcv antibodies without rna request to complete evaluation and prescription of treatment in cases of chronic infection. after patient identification from data files of laboratory and microbiology charts, patients will be randomized to: a) phone call, and b) invitation letter, both of two strategies including a scheduled appointment with the hepatologist.

this is a prospective, randomized study in which subjects lost to follow-up with positive hcv antibodies without rna request or positive rna will be proposed to be brought back into care. after patients identification from data files of laboratory and microbiology charts using three different cohorts in time (2005-07, 2011-11 and 2015-17), eligible patients (18 years of age or older, patients positive for hcv antibodies without rna request or positive rna lost to follow-up, with a valid sanitary card in our public health system and with available data for contact) will be randomized to: a) phone call (strategy 1), and b) invitation letter (strategy 2), both of two strategies including a scheduled appointment with the hepatologist. strategy 1 includes until three phone calls to contact patients and provide them with an appointment with the hepatologist (tertiary care center) over a period of 14 days according to patient availability. instead, strategy 2 includes an invitation letter providing patients with the appointment with the hepatologist over a same period of time than strategy 1. if there is no response to calls or no attendance to the appointment after the letter (randomized strategy), the strategy will be switched to the another one. epidemiological, clinical, and laboratory variables will be registered. the hypothesis of the study is that phone calls will improve the rate of linkage to care among hcv patients lost to follow-up compared to the invitation letter shipment. therefore, call would be an effective strategy to rescue these patients. for the present study, a 15% of improvement in linkage to care was hypothesized in the group of patients receiving the strategy 1 compared with the strategy 2. taking into account a power of 80%, alpha error of 5% and losses of 10% will require 176 patients per strategy.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. record of positive hcv antibodies without rna request or positive rna lost to follow-up (non-treated patients with an active infection, without surveillance by any hcv specialist) 3. patients a valid sanitary card in our public health system 4. patients with available data for contact) exclusion criteria: 1. belong to another catchment area. current surveillance by any hcv specialist and/or record of sustained virological response. 2. severe comorbidity with an expected survival lower than 1 year.

Keywords: hepatitis c lost to follow-up microelimination
wide awake local anesthesia no tourniquet

Conditions: Trigger Finger Disorder

Summary: the main objective is to assess patient's satisfaction regarding pure local anaesthesia and without use of a tourniquet (walant technique) for trigger finger release surgery.


Eligibility criteria:
inclusion criteria: * patients of age * isolated trigger finger, diagnosis confirmed by sonography and with indication of surgical release * patients protected by health insurance * patients who have received proper information on the current research proctol, and did not refuse to enter the study exclusion criteria: * hand vascular disorders ( history of finger replantation surgery, clinical signs of poor hand vascularization * hypersensitivy to xylocain or adrenalin or one of it's components * other surgical act planned to be performed during the same anaesthesia * pregnant or breastfeeding women * patients of age and under the protection of a conservator, patients deprived of liberty
prevalence of advanced fibrosis in patients living with hiv

Conditions: Fatty Liver Disease

Summary: monocentric, cross-sectional study to define the prevalence of advanced fibrosis in an hiv infected outpatient population. follow-up over 10 years to assess clinical relevance.

globally a shift in the spectrum of diseases has occurred. while in earlier year's infectious (communicable) disease were the main contributors to morbidity and mortality, today non-communicable diseases (ncd) exhibit a dramatic increase and have reached epidemic proportions, even in developing countries. diabetes, cardiovascular disease, and cancer are the most frequent ncds and the underlying risk factors including insulin resistance, dyslipidemia and obesity have been increasing over the last decades. the current study explores the prevalence of advanced fibrosis in an hiv-infected outpatient study population.

Eligibility criteria:
inclusion criteria: * informed consent * age \>18 exclusion criteria: * pregnancy * disease with expectation of life under 12 months

Keywords: non-invasive diagnostics
phase 3 trial to evaluate the efficacy and safety of yyc506.

Conditions: Dyslipidemias

Summary: phase 3 study to evaluate the effiacay and safety of yyc506

phase 3 study to evaluate the effiacay and safety of yyc506 in patients with complex dyslipidemia where ldl-c is properly controlled but tg and hdl-c levels are not regulated by atorvastatin alone.

Eligibility criteria:
inclusion criteria: * a man or woman over 19 years old. * ldl-c properly controlled, tg, hdl-c is not properly controlled * sign on icf prior to study participation exclusion criteria: * history of fibromyalgia, myopathy etc (ck ≥ 2xuln) * uncontrolled hypo-thyroidism (tsh≥1.5xuln) * severe renal impairemnet (creainine clearance \< 30ml/min) etc.