Kornimate/medical-research-clean huggingface dataset:
pupillometry in pediatric intensive care unit (picu)

Conditions: Pediatric Intensive Care

Summary: assess the depth of sedation and analgesia in pediatric intensive care is critical to the management of intubated patients under mechanical ventilation. the responsiveness of the pupil is changed by the sedation and analgesia. measuring the pupil diameter is proposed in anesthesia and intensive care to assess the quality of analgesia in adult population. visually measuring the diameter of the pupil remains very imprecise, but this measure can be accurately and quickly performed thanks to portable devices called pupillometers. some devices including algiscan® device (idmed ) can measure in addition to the pupil diameter, the variation of pupil diameter, the latency of the pupillary reflex and the maximum speed of contraction. pupillometry was tested in adult icu patients, during painful and painless procedures \[1\]. in this study, pupillometry was more sensitive for detecting pain compared to the change in heart rate or bispectral index. the objective of this work is to perform measurements of pupil diameter during painful procedures (e.g. tracheal aspiration) in picu. in parallel we will continue using the comfort b-scale (has been validated for assessment of pain in children admitted to a pediatric intensive care unit \[2-5\] and compare the results of both types of assessment pain.


Eligibility criteria:
inclusion criteria: * children (age \< 18 years) hospitalized in picu * sedated because they are receiving mechanical ventilation, * for whom parents (or their representatives) have given their oral consent after written information. exclusion criteria: * children receiving curare drugs * with congenital or acquired neurological, * with ophthalmologic pathology * or who does not benefit from social insurance coverage.

Keywords: pediatric intensive care pain assessment tracheal aspiration sedation pupillometer
effect of renin-angiotensin-system blockade on urinary free light chains in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes; Hypertension

Summary: the purpose of this study is to study the effect of blocking the renin angiotensin system on urinary free light chain excretion as compared to urine microalbumin creatinine ratio in subjects with type 2 diabetes. the long term goal is to assess urinary free-light chains as a biomarker of earlier detection of kidney function impairment in subjects with diabetes mellitus.

free light chains (flcs) are low-molecular-mass molecules (kappa and lambda light chains), which are by-products of normal immunoglobulin synthesis and are normally excreted through the kidneys. presence of light chains in the urine is a marker of tubular dysfunction. in patients with impaired kidney function, serum concentrations and urinary excretion of polyclonal flcs have been noted to be increased. increased excretion of flcs and other low-molecular weight proteins \[cystatin c, ngal\] in the urine may contribute to progression of chronic kidney disease. higher cystatin c has been demonstrated to be related to development of albuminuria. neutrophil gelatinase-associated lipcalin (ngal) excretion in the urine is a marker of tubular injury in the kidney and has been shown to be elevated in subjects with type 1 and 2 diabetes mellitus (dm). angiotensin-converting enzyme inhibitors (ace inh) and angiotensin ii receptor blockers (arb) class of drugs are renoprotective in nature and are the first line therapy for treatment of diabetic nephropathy. there is no longitudinal data evaluating the effect of ace inh and arb class of drugs on urinary flcs (uflcs). our hypothesis is that uflcs are increased in patients with dm with and without kidney disease and that treatment with ace inh and/or arb will decrease uflcs in these patients. additionally, we will explore the change in other low molecular weight proteins \[cystatin c, and ngal\] in response to treatment with ace inh and arb.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * hypertension * estimated glomerular filtration rate (egfr) \> 30 ml/min * use of ace inh and arb for control of blood pressure who are willing to be placed on alternate drug(s) in the washout period for blood pressure control exclusion criteria: * pregnancy * patients with chronic kidney disease stage with egfr \< 30 ml/min (ckd stage iv and v) * nephrotic range proteinuria (urinary protein \> 3.5 gm/day) * history or renal transplantation * history of multiple myeloma * known history of hypersensitivity reaction or intolerability to ace inh or arb.

Keywords: type 2 diabetes hypertension
human papillomavirus anal infection

Conditions: HPV Infection

Summary: human papillomavirus (hpv) are involved in up to 95 % of anal canal neoplastic lesions. little is known about hpv carriage in anal canal previous to cancer occurrence in the population and pre-neoplastic lesions, and their risk factors. papillan is a prospective study that aims to study hpv infection (hpv low grade and high grade genotypes) prevalence in anal canal in a population non selected by its hiv status. in that purpose patients are prospectively recruited in a french university hospital gastroenterology unit and anal smears are collected during a colonoscopy with cytobrush.


Eligibility criteria:
inclusion criteria: * patients \> 18 years * patients undergoing colonoscopy under general anesthesia for any purpose * signed written consent exclusion criteria: * age under 18 * absence of written consent. * patients incapable of giving consent

Keywords: colonoscopy
study evaluating the safety and response of fosbretabulin in asian patients with polypoidal choroidal vasculopathy (pcv)

Conditions: Polypoidal Choroidal Vasculopathy

Summary: the primary objective of this study is to examine effects of fosbretabulin tromethamine (fosbretabulin) on pcv as reflected by a change from baseline in the number of polypoid lesions on indocyanine green angiography (icga).


Eligibility criteria:
inclusion criteria * male or female age ≥21 years. * asian race (e.g. chinese, japanese, korean, thai). * polypoidal choroidal vasculopathy in the study eye * presence of ≥ 1 visible polypoidal varicosity on icga. * presence of a measurable branching vascular network * bcva by etdrs of 68 to 4 letters in the study eye. ophthalmologic exclusion criteria * prior treatment with intravitreal or systemic anti-vegf therapy within 60 days of enrollment. * any other prior treatment for pcv including thermal laser photocoagulation, photodynamic therapy (i.e., verteporfin), or any investigational therapies. * any history of prior retinal or subretinal surgery, transpupillary thermography, radiation, implantation of intravitreal drug delivery device, vitrectomy. * any other intraocular surgery or laser treatment within 90 days or any surgeries planned during the study period. * fibrosis involving ≥50% of the total lesion. * presence of hemorrhage which potentially obscures \>75% of vascular pathology to be assessed by imaging procedures. * retinal or choroidal vascular disease in study eye due to causes other than pcv, such as uveitis, trauma, or pathologic myopia. * macular edema in either eye due to other causes, such as diabetic retinopathy. * evidence of glaucomatous eye disease, glaucomatous visual field loss. * history of allergy to fluorescein or icg dye. medical exclusion criteria * current or history within two years of any significant heart disease. * uncontrolled hypertension.

Keywords: polypoidal choroidal vasculopathy pcv polypoid oxigene vda vascular disrupting agent combretastatin fosbretabulin
sexually transmitted infections with mycoplasma genitalium: epidemiological, clinical, microbiological, therapeutic aspects

Conditions: Anorectal Infection

Summary: infectious anorectitis is a poorly described clinical entity. their epidemiology is poorly known, as are their clinical, diagnostic (diagnoses are regularly made in gastroenterology and new diagnostic tools are now available) and therapeutic aspects. the proctology center of the marie thérèse center is the leading proctology center in the ile-de-france region both in terms of recruitment and reputation, and drains a large proportion of patients with anorectitis for specialized care. the clinical microbiology laboratory of the saint joseph hospital group is linked to the marie thérèse center to provide its expertise in the microbiological and infectious aspects of the management of these infections. in recent years, the analysis of data from this large population of patients referred to the léopold bellan proctology center for suspected ano-rectitis has revealed the pathogens neisseria gonorrhoeae and/or chlamydia trachomatis. mycoplasma genitalium (mg) is an emerging pathogen responsible for sexually transmitted infections (sti) and has been described increasingly in recent years. studies on this pathogen will allow to better identify risk factors and to target optimized prevention and therapeutic management strategies.


Eligibility criteria:
inclusion criteria: * patient whose age is ≥ 18 years * patients treated at the centre de proctologie of the centre de santé marie-thérèse or the ghpsj (consultation and/or hospitalization) and for whom an anorectal swab will be taken for suspected infectious sexually transmitted ano-rectitis * french-speaking patient exclusion criteria: * patient under guardianship or curatorship * patient deprived of liberty * patient under court protection * patient objecting to the use of his data for this research
effects of clamshell versus gluteal bridge exercises

Conditions: Lower Crossed Syndrome

Summary: gluteal amnesia is a "condition" where the individual is believed to have lost the ability to contract their gluteal muscles - generally the gluteus maximus, though some report it as the gluteus medius. this can take many different names, such as "dead butt", "sleeping glutes", or glutes that are "turned off".since the gluteus medius normally helps stabilize the pelvis, gluteal amnesia can lead to lower back pain and hip pain, as well as knee and ankle issues, as the body tries to compensate for the imbalance.

a randomized controlled trial will be conducted at jinnah hospital physiotherapy clinic \& boston physiotherapy and wellness clinic through consecutive sampling technique on 32 patients which will be allocated through simple random sampling through sealed opaque enveloped into group a \& group b. group a will be treated with clamshell exercises at the frequency of 3 sets with 10 repetitions 3 times/ week with baseline treatment. group b will be treated with gluteal bridge and baseline treatment. baseline treatment for both groups will be given hot pack at low back for 10 minutes and quadriceps and hamstring stretching 3 times with 30 seconds hold. outcome measures will be conducted through pain, disability and quality of life questionnaire after 6 weeks. data will be analyzed during spss software version 21. after assessing normality of data by shapiro -wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * • female between the ages of 20 to 40 years * prolonged sitting hours \>4 hours. * examination- symptoms provoked by low back movement. * positive gluteal strength test * positive slr for hamstring tightness * positive thomas test for rectus femoris tightness. exclusion criteria: * • osteoporosis * malignancy * vertebral fractures * pervious or scheduled surgery * trauma * pregnancy * psychological conditions

Keywords: gluteal weakness disability pain gluteal amnesia
ma-spore all 2020 study

Conditions: B Lymphoblastic Leukemia

Summary: the primary objective of this trial is to improve the overall survival rate of children and young adult with b-lineage acute lymphoblastic leukemia (b-all) in singapore and malaysia in the context of a multicenter cooperative trial using a risk-stratified therapy.

this is a multicenter open-label phase ii study involving children and young adult (\< 41 years old) who are newly diagnosed with b-all and treatment naïve. there will be 3 parallel cohorts whose risk to be stratified based upon leukemia genetics profiles and patient's treatment response: 1. standard risk (sr) 2. intermediate risk (ir) 3. high risk (hr) all drugs being used are commercially available chemotherapy drugs. there will be no novel chemotherapeutic agent without marketing authorization being tested in this trial.

Eligibility criteria:
inclusion criteria: 1. has been diagnosed with b-lineage all as evidenced by: 1. bma blasts \> 20% and 2. leukemic process in the bone marrow, peripheral blood or any extra medullary tissue with confirmation of b-lymphoid differentiation by flow immunophenotyping or histopathologically 2. age \< 41 years of age at enrolment 3. written informed consent obtained from patient or legally acceptable representative (lar) exclusion criteria: 1. t-lineage all 2. down syndrome with all 3. history of previous malignancies or this all is a second malignancy 4. mixed phenotype acute leukemia (mpal) or undifferentiated leukemia 5. mature b-cell leukemia/lymphoma 6. any previous cytotoxic therapy (chemotherapy/radiotherapy/immunotherapy). patient pre-treated with short term steroid (\< 7 days of duration within last 1 month prior to all treatment start) may be enrolled after discussion and written approval from pi. these patients should be treated on at least intermediate arm. 7. persistent renal dysfunction with creatinine more than upper limit of normal for age before start of induction therapy. patients requiring temporary dialysis without persistent renal dysfunction can qualify. 8. liver dysfunction with direct bilirubin \> 10x upper normal limit for age. 9. any serious uncontrolled medical condition or impending end organ dysfunction that would impair the ability of the subject to receive protocol therapy 10. doubtful compliance or ability to complete study therapy due to financial, social, familial or geographic reason, or in the judgement of site investigator
use of local infiltration analgesia following total hip arthroplasty

Conditions: Pain, Postoperative; Pain

Summary: the primary aim of this study is to evaluate if multiple postoperative administrations with a solution of ropivacaine, ketorolac and epinephrine into the operating field through a catheter would affect morphine consumption. secondary end-points are pain intensity, side effects and length of stay.


Eligibility criteria:
inclusion criteria: * patients scheduled for total hip arthroplasty * patients \> 18 years of age * signed written informed consent * spinal anaesthesia exclusion criteria: * allergy towards study drugs * rheumatoid arthritis * body mass index \> 35 (severe obesity) * pregnancy or nursing women * regular opioid use * patients who can not read or understand danish
one week assessment of the phenacite lens

Conditions: Myopia

Summary: this study will investigate performance criteria over one week of daily wear to determine if the study test contact lens performs equivalently to the comfilcon a contact lenses in terms of subjective ratings and of visual performance. the study test lens was not the final optical design and the study results were not used for the design validation.

this will be double-masked, randomized, bilateral crossover study comparing the study test lens against the comfilcon a control lens, each worn over one week of daily wear. the study test lens was not the final optical design and the study results were not used for the design validation.

Eligibility criteria:
inclusion criteria: * a person is eligible for inclusion in the study if he/she: * oculo-visual examination in the last two years * between 18 and 35 years of age and has full legal capacity to volunteer * has read and understood the informed consent letter * is willing and able to follow instructions and maintain the appointment schedule * is correctable to a visual acuity of 20/25 or better (in each eye) with their habitual correction or 20/20 best corrected * currently wears, or has previously successfully worn, soft contact lenses between -1.00d (diopter) and -4.50d * spherical contact lens rx between -1.00 and -4.00 and spectacle cylinder \<-0.75 * currently spends a minimum of 4 hours a day; 5 days a week on digital devices and can replicate this time during the study period * is willing and able to wear the study contact lenses a minimum of 10 hours per day; 5 days a week. exclusion criteria: * a person will be excluded from the study if he/she: * has never worn contact lenses before. * has any systemic disease affecting ocular health. * is using any systemic or topical medications that will affect ocular health. * has any ocular pathology or severe insufficiency of lacrimal secretion (moderate to severe dry eyes) that would affect the wearing of contact lenses. * has persistent, clinically significant corneal or conjunctival staining using sodium fluorescein dye. * has any clinically significant lid or conjunctival abnormalities, active neovascularization or any central corneal scars. * is aphakic. * has undergone corneal refractive surgery. * is participating in any other type of eye related clinical or research study.
peking university birth cohort in tongzhou

Conditions: Health Problems in Pregnancy; Pregnancy Outcomes; Gestational Diabetes; Gestational Hypertension; Preterm Birth; Obesity; Mother-Infant Interaction; Child Development; Anemia

Summary: the pkubc-t is a prospective cohort study carried out in tongzhou district of beijing, china. the primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. biological samples including blood and tissue samples are also collected from mothers and their children.

maternal and child health is of great concern globally. early life phase of a fetus and infant is a critical period for the development of health and disease in the whole life. exposure of negative environmental, nutritional and lifestyle factors in pregnant women during this period can have adverse effects on fetal and infant. in addition, for mothers, complications during pregnancy could also have a negative effect on long-term health of mothers, such as diabetes, hypertension. thus, the peking university birth cohort in tongzhou is primarily aimed to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. biological samples including blood and tissue samples are also collected from mothers and their children.

Eligibility criteria:
inclusion criteria: 1. pregnant women, \<14 gestational weeks 2. resided in tongzhou in the past half years and have no plan to move out after delivery 3. pregnant women who plan to have antenatal care and delivery in tongzhou maternal\&child hospital. 4. pregnant women who is willing to participate in this study with informed consent exclusion criteria: pregnant women have chronic disease before pregnancy, including diabetes，hypertension, liver disease and kidney disease.
cost-effectiveness analysis of a virtual reality-assisted hypnotherapy program on quality of life in patients with chronic neck pain: a multicenter, randomized, prospective, comparative, open-label, parallel-group study

Conditions: Chronic Neck Pain; Neck Pain

Summary: this randomized, prospective study aims to evaluate the effectiveness and cost-efficiency of a virtual reality (vr)-assisted hypnotherapy program on quality of life in patients with chronic neck pain. the study compares a vr-assisted hypnotherapy group to a standard treatment group. both groups will undergo a conventional physical therapy program supervised by physiotherapists for 3 weeks (15 sessions). the vr-assisted hypnotherapy group will receive additional sessions utilizing the hypnovr software, which delivers relaxing virtual environments. outcomes will be assessed immediately after treatment, at 1 month, and at 3 months post-treatment. primary endpoints include pain reduction measured by the visual analog scale (vas). secondary endpoints include functionality, quality of life, anxiety, depression, sleep quality, healthcare costs, and treatment adherence. statistical analyses will determine the efficacy and economic impact of this innovative therapy for chronic neck pain management.


Eligibility criteria:
inclusion criteria: * age between 50 and 80 years. * chronic neck pain lasting for more than 3 months. exclusion criteria: * history of spinal surgery. * beck depression inventory (bdi) score \>16. * presence of neurological deficits or concurrent neurological diseases. * medical conditions incompatible with the use of vr headsets (e.g., vision problems, epilepsy). * pregnancy. * recent changes in medication for chronic pain within the past 3 months (e.g.,- pregabalin, gabapentin, duloxetine).

Keywords: hypnotherapy virtual reality
neuromuscular electrical stimulation in chronic low back pain

Conditions: Low Back Pain

Summary: this study evaluates whether there is additive effect of neuromuscular electrical stimulation applied to lower lumbar region to core stabilization exercises in the management of chronic low back pain. participants will randomly divide into two groups; half will receive core stabilization exercises and neuromuscular electrical stimulation (nmes) in combination, while the other half will receive core stabilization exercises and sham nmes.

patients with low back pain cannot activate enough the deep lumbar stabilization muscles necessary for spinal stability, such as transversus abdominis, lumbar multifidus. core stabilization exercises are valuable in motor relearning of coactivation of deep lumbar and abdominal muscles and in stabilization of the spine. hence, they are important in the management of chronic low back pain. neuromuscular electrical stimulation (nmes) has been used in the training and strengthening of skeletal muscles for many years. it is shown that nmes can contract deep lumbar stabilization muscles and changes in muscle activation are significantly associated with pain reduction in patients with low back pain.

Eligibility criteria:
inclusion criteria: * 18 years or older, * pain intensity greater than 3 over 10, * pain duration more than 3 months, * consent to participate in the study exclusion criteria: * previous lumbar surgery, * radiculopathy, * non-mechanical back pain, * acute low back pain

Keywords: electric stimulation ultrasonography exercise therapy rehabilitation