Kornimate/medical-research-clean huggingface dataset:
a phase 2 study to evaluate the safety and efficacy of ckd-498 in female patients with androgenetic alopecia

Conditions: Androgenetic Alopecia

Summary: this is a multi-centers, randomized, double-blind, parallel-group, phase 2 trial to evaluate the efficacy and safety of ckd-498 in female patients with androgenetic alopecia

participants were randomly assigned in a 1:1:1:1 ratio to the following group: 3 dose of ckd-498 and placebo. the patients are prescribed oral administration of the appropriate ip daily (3 tablets: actual medication and placebo) for 24 weeks.

Eligibility criteria:
key inclusion criteria: * female of age 19-54 years * clinical diagnosis of androgenetic alopecia * written informed consent key exclusion criteria: * other types of alopecia or other diseases that can cause hair loss * clinically significant scalp disease such as seborrheic dermatitis or psoriasis * clinically significant hepatic disease, thyroid disease, or mental illness, as determined by the investigator * women who are pregnant or breastfeeding * women of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for up to 4 weeks after the last dose of study drug

Keywords: androgenetic alopecia ckd-498
inguinal hernia and arterial disease

Conditions: Inguinal Hernia; Arterial Disease

Summary: inguinal hernias are associated with problems related to the venous system by the linking to extracellular matrix alterations (ecm). on the other hand, arterial diseases (arterial aneurysms, carotid, stenosis, peripheral artery disease) are widespread in the general population and may share others pathological pathways related to ecm impairment. aim to this study is to evaluate the prevalence of arterial diseases in patients with inguinal hernia.

previous studies showed the correlation between inguinal hernias and venous disease. the common pathophysiological pathway between these clinical conditions is linked to extracellular matrix (ecm) alterations. arterial diseases, mainly represented by carotid stenosis, peripheral artery disease and arterial aneurysms, are widespread in western population and are responsible of high rates of morbidity and mortality. these diseases are also related to some ecm alterations. aim of this cross-sectional study is to evaluate the prevalence of arterial disease among patients with inguinal hernias. the primary endpoint of this study is to provide new epidemiological evidences on this association that may help physicians in novel preventive strategies. the study will consider the inclusion of consecutive patients assessed for inguinal hernia over 1 year period in order to study the prevalence of concomitant arterial disease, by means of office visit, echo duplex scan of the aorta and its main branches, carotid arteries and lower limb arteries.

Eligibility criteria:
inclusion criteria: * patients with inguinal hernia exclusion criteria: * patients with malignancies

Keywords: inguinal hernia arterial disease peripheral artery disease carotid stenosis arterial aneurysm
effect of product related factors on platelet concentrate transfusion response in patients with hematologic malignacies

Conditions: Lymphoma; Multiple Myeloma; Lymphocytic Leukemia; Hodgkin Disease

Summary: platelet concentrates (pcs) characteristics, such as storage duration, abo compatibility, dose and source, may have an impact on transfusion responses and outcomes. because of the relative scarcity of pcs the selection of a specific pc for issue to the patient remains a challenging process. regulatory agencies do not fully address these characteristics in their recommendations for prophylactic transfusions. the aim of the study was to analyse the effect of product-related factors in a real life setting, in order to determine which ones are the most relevant when selecting pcs for patients in prophylactic conditions. two different endpoints are studied: the corrected count increment and the platelet transfusion time intervals.


Eligibility criteria:
inclusion criteria: * inpatients in the hematology department between january 2001 and december 2012 * hematologic malignancy * at least one platelet transfusion (with platelet count ≤ 25 g/l) * age 18 and over at time of first transfusion exclusion criteria: * more than one hematologic malignancy * non-malignant haematological disorder

Keywords: platelet transfusion
outcomes of a skill-based program for eating disorders

Conditions: Anorexia Nervosa

Summary: this study aims to measure the effect of a neurobiologically-guided intensive family based treatment for adults with anorexia nervosa.


Eligibility criteria:
inclusion criteria: * current diagnosis of anorexia nervosa * illness onset at least 2 years prior to study * medically stable * identified carer to participate in treatment with participant exclusion criteria: * developmental or intellectual disorder * diagnosis of substance abuse or dependence in 3 months prior to study * current suicidal thoughts * severe comorbid psychiatric disorder (e.g., psychotic disorder, bipolar disorder)
patient-centered care for the older adult with hematologic malignancy

Conditions: Hematologic Malignancy

Summary: this research study is evaluating if co-management by a geriatrician embedded in the oncology clinic can improve outcomes for frail older adults with blood cancers. a rigorous pre-entry frailty assessment by a trained research assistant will be followed by randomization to geriatrician co-management versus usual care for patients found to be frail or pre-frail.

older adults have unique health concerns, and in particular, older adults with blood cancers may have different disease and other health related issues than younger adults with similar diagnoses. one aspect of aging which can make older adults more vulnerable is frailty. frailty is a general term that describes a decline in multiple areas of health, including the loss of energy, physical ability, and mental ability. frailty can make it difficult for patients with cancer to respond to treatment and more likely to have side effects. on the other hand, many older patients are not frail despite advanced age. this study is being done to determine if co-management by a geriatrician of older adults who are found to be frail through a detailed baseline assessment can improve outcomes.

Eligibility criteria:
inclusion criteria: * all patients aged 75 and older who present for an initial consultation at the dana-farber/brigham and women's cancer center for hematologic malignancy (transplantation consultation excluded). * assessed to be pre-frail or frail on formal baseline geriatric assessment. exclusion criteria: * not willing to participate

Keywords: hematologic malignancy geriatric assessment geriatric oncology frailty
ocular microbiome and immune system in dry eyes

Conditions: Dry Eye Disease

Summary: the primary objectives of this study are the characterization of the ocular microbiome as well as of the local immune system in participants with and without dry eye disease. secondary objectives are the identification of differences in the ocular microbiome as well as in the immune system between participants with and without dry eye disease to ultimately find associations between the ocular microbiome and the immune system in dry eye disease.

although dry eye disease is considered to be one of the most common ocular surface diseases worldwide, treatment options are only very limited and severe side effects are common. however, recent studies showed that the ocular microbiome may be crucial for maintaining ocular surface homeostasis. disruption of this homeostasis, called dysbiosis, may lead to inflammation that is a key component in the pathogenesis of dry eye disease. it has been suggested that bacteria are invasive in ocular mucosal tissue, thereby effectively hidden from clearance by the local immune system and rendering the inflammation chronic. therefore, the investigators hypothesize that the ocular microbiome may induce changes in the mucosal immune system of the eye, which in turn may accelerate the development of dry eyes. since there is a crucial role of both, the ocular microbiome and the local mucosal immune system, on several diseases, the overall aim of this project is to assess the associations of the mucosal immune system and the ocular microbiome in dry eye disease.

Eligibility criteria:
inclusion criteria: * willing to sign informed consent * 18 years of age or older exclusion criteria: * not willing or able to sign informed consent * younger than 18 years * recent (3 month) history of use of systemic and/or topical antibiotics * usage of medical eye drops (lacrycon and other moisturizing eye drops are allowed) * recent (3 month) history of ocular surgery

Keywords: microbiome immune system
frozen shoulder treated by energy accumulator

Conditions: Frozen Shoulder

Summary: frozen shoulder is a painful and disabling disorder of unclear cause, affecting middle-age people after their 5th decades. they suffer from annoying pain and limited shoulder mobility. energy accumulator provides a better way of relief through an integrative medicine concept.

frozen shoulder is common among middle-aged persons in the 5th and 6th decades. the pain can be acute or chronic. patients feel stiffness over the shoulder, shown by restriction in range of motion. the etiology includes trauma, cervical disc degeneration, physical strain, psychosocial problems and even genetic factors. the predisposing factors include immobilization of the arm for a long time, rotator cuff or biceps tendinitis, tenosynovitis of the long head of the biceps, congenital deformity of the shoulder girdle, scapula-costal cementing, ligamentous injury, osteoarthritis, muscular fibrosis or nutritional deficiencies. the pathology is unclear but it is widely believed that it is related to inflammation in the joint and surrounding soft tissues which lead to fibrosis. frozen shoulder can be divided into primary frozen shoulder which occurs spontaneously without other diseases; and secondary frozen shoulder is associated with joint diseases, such as osteoarthritis or fractures. ukfrost was a multi-centre randomized clinical trial comparing 3 parallel groups (arms) of frozen shoulder patients treated 1) under anaesthesia + steroid injection 2) under anaesthesia + arthoscopy, and 3) physiotherapy + steriod injection..the large-scale study proves physiotherapy program beneficial to frozen shoulder patients, and, the effectiveness might further improve by introducing east-meets-west component - chinese medicine.

Eligibility criteria:
inclusion criteria: * male or female gender with age between 40-65 * affect one shoulder only * onset is more than 3 months at the time of inclusion into the study exclusion criteria: * unstable medical conditions * unstable mental state * have skin lesion over the shoulder * skin sensitivity to heat * pregnant or under lactation * could not comply with heat treatment of the shoulder.

Keywords: frozen shoulder integrative medicine energy accumulator
clinical evaluation of effectiveness and safety of amberen and smart b in perimenopausal women.

Conditions: Perimenopause, Climacteric Syndrome

Summary: to evaluate effectiveness and safety of combined use of dietary supplements amberen and smart b in women with a typical (without complications) form of climacteric syndrome, with mild to moderate symptoms in perimenopause.

1. to evaluate effectiveness of combined use of dietary supplements amberen and smart b in women vasomotor, psychosomatic, psychological and other climacteric symptoms in perimenopause. 2. to evaluate safety of combined use of dietary supplements amberen and smart b in women with vasomotor, psychosomatic, psychological and other climacteric symptoms in perimenopause. 3. to develop recommendations for combined use of dietary supplements amberen and smart b for women with vasomotor, psychosomatic, psychological and other climacteric symptoms in perimenopause.

Eligibility criteria:
inclusion criteria: * female subjects, 50 years of age or younger; * subjects in the second phase of menopausal transition as per straw 10+ i.e. interval of amenorrhea 60 days or more (with regular menstrual cycle during earlier reproductive stages). * subjects with diagnosis of mild to moderate climacteric syndrome; * recent (up to 12 months prior to study enrollment) breast exam results, including mammogram, that rule out malignancies; * recent (up to 3 years prior to study enrollment) cytological screening that rules out vaginal cervix malignancies. * ability to read and understand informed consent form for the study's participation; * ability to adhere to the conditions of the study. exclusion criteria: * • postmenopause, including surgical menopause. * presence of hormone-dependent cancers; * presence of other cancers, not in full remission with no recurrence for 5 years or more; * planned hospitalization in the next 6 months; * presence of hormonally-active extragenital endocrine diseases (diabetes; diseases of thyroid, adrenal, pituitary) that require prolonged or life-long therapies * surgical interventions on sex organs or breasts, 1 year or less prior to the screening; * gynecological conditions that may require hormonal therapies or surgeries (uterine myoma, endometriosis, endometrial hyperplasia etc.); * currently undergoing or planning to utilize assisted reproductive technologies; * any abdominal surgeries within less than 3 months prior to the screening; * hrt including mhrt or hormonal contraceptives - current or within less than 3 months prior to the screening; * psychiatric conditions; * patients taking any other dietary supplements that can affect climacteric syndrome within the last month before enrolling in the trial; * high risk of non-compliance.

Keywords: succinate b complex vitamins perimenopause
pelvic belt effects on osseous anatomy, muscule activation and ground reaction forces

Conditions: Sacroiliac Joint Pain; Helath Related Quality of Life; Electromuscular Activation of the Pelis and Limbs; Ground Reaction Force Data

Summary: hypothesis i: the anatomic alignment of the pelvic bones, the electromuscular activation of limb muscles and ground reaction forces are different in patients with sacroiliac joint pain, as compared to healthy controls. hypothesis ii: the application of pelvic belts alters the alignment of the pelvic bones, the electromuscular activation of the limb muscles or ground reaction forces. hypothesis iii: the effects proposed in hypothesis ii are different in patients with sacroiliac joint pain, as compared to healthy controls.

the sacroiliac joint is among the most frequently involved anatomical structure in low back pain. pelvic belt anatomy makes the sacroiliac joint more vulnerable to be involved in chronic painful conditions. however, the anatomical and functional correlate of sacroiliac joint pain is yet undetermined. according to the guidelines of international association for the study of pain (iasp), painful conditions should primarily be managed conservatively. however, existing studies fail providing sound evidence on the effects of conservative devices to therapy sacroiliac joint pain. in the study, a total of 17 patients suffering from sacroiliac joint pain and 17 controls were investigated by means of magnetic resonance imaging, emg, health surveys and ground reaction force measurements. a pelvic compression belt was administered in two levels of compression and the corresponding magnetic resonance imaging, emg and ground reaction force data were measured.

Eligibility criteria:
inclusion criteria: * patients with diagnostically confirmed sacroiliac joint pain * controls without any history of musculoskeletal disorders exclusion criteria: * endoprostheses, metallic implants * somatoform disorders, claustrophobia, pregnancy * surgical interventions on the spine, degenerative joint diseases elsewhere
effects of brs and lrs on postoperative acute kidney injury

Conditions: Acute Kidney Injury

Summary: 1. title: effects of sodium bicarbonate ringer's injection and sodium lactated ringer's injection on postoperative acute kidney injury in patients undergoing major abdominal surgery: a randomized, controlled, open-label clinical study 2. objective: to evaluate the effect of brs and lrs infusion on acute renal injury in patients undergoing major abdominal surgery 3. primary outcome: incidence of aki at 28 days postoperative (defined as acute kidney injury, according to kidgo 2012 definition and classification). 4. study design: randomized, controlled, open-label clinical study.

1. subjects: patients who planned to undergo elective major abdominal surgery. 2. study data collection period: subjects signed the consent form until 28 days after discharge or died in hospital or withdrew from the study. 3. number of research centers/sample size: 3400 patients were planned to be included. 4. study process: among patients undergoing elective surgery, the researchers will include patients who meet the inclusion criteria for elective major abdominal surgery and agree to participate in the study. the data to be collected in this study will be recorded by the researcher in the ecrf, including: (1) data to be collected during the screening period and preoperatively: patients' basic characteristics and demographic data (2) data to be recorded during and/or after surgery: primary study indicators, secondary indicators, and other indicators.

Eligibility criteria:
inclusion criteria: 1. asa grade ⅰ-ⅲ. 2. patients aged between 20 and 70, signed informed consent form, and are willing to participate in the study. 3. bmi ≤ 30kg/m2. 4. elective major abdominal surgery for the first time (radical resection of ovarian cancer, radical resection of cervical cancer, radical resection of gastric cancer, radical resection of colorectal cancer, radical resection of bladder tumor and radical resection of prostate tumor). 5. nyha cardiac function grade ⅰ-ⅲ. 6. the function of liver and kidney is normal before operation. 7. the blood coagulation function was normal before operation. 8. hemoglobin \> 70g/l. 9. sinus rhythm was detected by electrocardiogram and there were no other malignant arrhythmias. exclusion criteria: 1. emergency surgery. 2. liver and kidney surgery. 3. complicated with chronic respiratory diseases and fev1/fvc \< 70%. 4. the operation time is less than 2 hours. 5. patients with mental illness or cognitive impairment. 6. uncontrolled hypertension with blood pressure higher than 180 × 100mmhg. 7. patients with hypothyroidism. 8. pregnant or lactating patients. -
pediatric acute respiratory distress syndrome asia study

Conditions: Acute Respiratory Distress Syndrome; Pediatric Intensive Care Unit; Mechanical Ventilation

Summary: mortality rates in children with pediatric acute respiratory distress syndrome (pards) are higher in asia compared to other regions. in adults with acute respiratory distress syndrome, the only therapy that improves mortality rates is a lung protective ventilation strategy. the pediatric ventilation recommendations are extrapolated from evidence in adults, including ventilation with low tidal volume, low peak/plateau pressures and high-end expiratory pressure. a recent retrospective study of ventilation practices in asia showed varying practices with regards to pulmonary and non-pulmonary therapies, including ventilation. this study aims to determine the prevalence and outcomes of pards in the pediatric acute and critical care medicine asian network (paccman). this study will also determine the use of pulmonary (mechanical ventilation, steroids, neuromuscular blockade, surfactant, pulmonary vasodilators, prone positioning) and non-pulmonary (nutrition, sedation, fluid management, transfusion) pards therapies. to achieve this aim, a prospective observational study which involves systematic screening of all pediatric intensive care unit (picu) admissions and collection of pertinent clinical data will be conducted. recruitment will be consecutive and follow up will continue to intensive care discharge.

the overall objective of this study is to prospectively determine the epidemiology of children with pards and describe its management in asia. the first specific aim is to determine the prevalence of pards among picu admissions. this will be achieved by establishing a systematic manner of screening patients and including them in this study. the second specific aim is to describe the use of pulmonary and non-pulmonary therapies in pards. this study will utilize an established dataset to extract pertinent and analyzable clinical data.the third specific aim is to determine the outcome of patients with pards. these outcomes will include functional data, picu mortality, ventilator duration and length of stay data. this is a two-part study - the first part to establish the baseline prevalence and ventilator management strategies, the second part will include the implementation of an evidence based ventilation protocol as part of routine care. the same screening process, eligibility criteria and data collection will apply throughout the two parts. we aim to obtain data for approximately 2years prior to and 2years subsequent to the implementation of the ventilator protocol.

Eligibility criteria:
inclusion criteria: * satisfies the pediatric acute lung injury consensus conference (palicc) criteria for pards exclusion criteria: * premature neonates with a corrected age of less than 33 weeks and perinatal lung disease * high flow nasal cannula
yoga and rate and duration of inappropriate sinus tachycardia (ist) episodes

Conditions: Inappropriate Sinus Tachycardia

Summary: inappropriate sinus tachycardia (ist) is an uncommon form of atrial tachycardia. the term "inappropriate" in medicine is commonly defined as a heart rate greater than 100 beats per minute at rest or with minimal physiological challenge. ist is characterized by an increased resting heart rate with an exaggerated response to exercise or stress. yoga has been used extensively around the world as an alternative medicine approach in treating numerous chronic and debilitating diseases. studies have been conducted in various countries to determine the benefits of yoga as therapy for these chronic diseases. several studies have confirmed that yoga can reduce anxiety and regulate the stress response. studies in the past have shown that yoga relieves stress, one of the most common triggers for the arrhythmia and increased heart rate in ist. based on past studies we hypothesize that patients with ist might benefit by practicing yoga. yoga may also help in better rate and rhythm control with yoga when employed in combination with usual medical arrangement.


Eligibility criteria:
inclusion criteria: * patients diagnosed with inappropriate sinus tachycardia exclusion criteria: * advanced malignancy or severe co-morbidities such as severe heart failure and with life expectancy less than 1 year * pregnant women * patients with unmedicated or uncontrolled high blood pressure * patients with past history of pnuemothorax * patients with severe cervical spondylitis and cervical, thoracic, or lumbar disc prolapse * patients with carotid stenosis * patients with history of psychosis (evidence of acute episodes with deep and prolonged meditation) or substance abuse * patients with history of epilepsy (evidence of acute episodes with deep and prolonged medication) * patients with glaucoma * patients with history of total hip replacement

Keywords: yoga atrial tachycardia