Kornimate/medical-research-clean huggingface dataset:
complement inhibition: attacking the overshooting inflammation @fter traumatic brain injury

Conditions: Traumatic Brain Injury; Trauma, Head

Summary: severe traumatic brain injury (s-tbi) is a major cause of death and disability across all ages. besides the primary impact, the pathophysiologic process of major secondary brain damage consists of a neuroinflammation response that critically leads to irreversible brain damage in the first days after the trauma. a key catalyst in this inflammatory process is the complement system. inhibiting the complement system is therefore considered to be a potentially important new treatment for tbi, as has been shown in animal studies. this trial aims to study the safety and efficacy of c1-inhibitor compared to placebo in tbi patients. by temporarily blocking the complement system we hypothesize limitation of secondary brain injury and more favourable clinical outcome for tbi patients due to a decrease in the posttraumatic neuroinflammatory response.


Eligibility criteria:
inclusion criteria: * age at admission ≥ 18 years and \< 65 years; * clinical diagnosis of traumatic brain injury with gcs \< 13 (with intracranial deviations); * catheter placement for monitoring and management of increased icp for at least 24 hours; exclusion criteria: * a clear, non-traumatic cause of low gcs (e.g. toxic, cardial) on admission; * not expected to survive more than 24 hours after admission; * brain death on arrival in the participating centers; * severe pre-trauma disability, defined as being dependent on other people; * known prior history of sensibility to blood products or cinryze; * patients with a history of hereditary angioedema; * patients with a history of thrombosis; * pregnant women.

Keywords: traumatic brain injury c1-inhibitor neuroinflammation efficacy safety
acute effects of oral carbohydrate and fat loads on systemic microvascular endothelial function in healthy individuals.

Conditions: Metabolic Syndrome

Summary: the present study was designed to evaluate vascular endothelial dysfunction resulting from the oral ingestion of high loads of sugar and fat meals in healthy individuals.

the chronic and elevated consumption of fat and carbohydrates is associated with the initiation and the progression of cardiovascular and metabolic diseases, including diabetes, obesity and metabolic syndrome. in general, chronic diseases are related to underlying modifiable cardiovascular risk factors, including high blood pressure, high plasma lipids and glucose, physical inactivity, overweight and obesity, as well as smoking habits. vascular endothelial dysfunction is one of the earliest findings in the pathophysiology of atherosclerosis and also an important predictor of cardiovascular events. moreover, it has already been demonstrated that acute oral ingestion of high loads of sugar and fat meals induces transient vascular endothelial dysfunction, which over time could lead to cardiovascular disease. thus, the present study aimed at investigating the individual contributions of sugar and fat ingestion on systemic microvascular endothelial reactivity.

Eligibility criteria:
inclusion criteria: * healthy individuals presenting body mass index between 18.5 e 24.9 kg/m2 exclusion criteria: * dysglycemia and dyslipidemia * overweight and obesity

Keywords: vascular endothelial function systemic microvascular reactivity dysglycemia dyslipidemia
multiple sclerosis and progressive resistance training

Conditions: Multiple Sclerosis (Relapsing Remitting)

Summary: the purpose of this study is to investigate underlying mechanisms possibly explaining the beneficial effects of progressive resistance training for people with multiple sclerosis.

exercise in general, and progressive resistance training (prt) in particular, is regarded as an important tool in the rehabilitation of people with multiple sclerosis (ms). previous studies have reported positive effects of prt on muscle strength, functional capacity, fatigue and quality of life. also, a possible disease modifying effect has been proposed. however, the underlying physiological mechanisms that might explain these beneficial effects and the possible effects on disease progression are unresolved. additionally, none of the previous studies has been concerned with the possible impact of ms progression type, gender and/or medication. the purpose of this randomized, controlled, gender stratified trial is to investigate underlying mechanisms possibly explaining the beneficial effects of progressive resistance training for people with multiple sclerosis.

Eligibility criteria:
inclusion criteria: * diagnosed relapsing-remitting ms according to the mcdonald criteria * expanded disability status scale (edss) between 2.0 and 5.5 * be able to train twice a week at the university * use interferon based medication exclusion criteria: * alcohol abuse, alzheimer's and pacemaker (or other metallic implant) * comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases * having had an attack in a period of 8 weeks prior to the start of the intervention period * having an attack during the intervention period * pregnancy * systematic resistance training in a period of 3 months prior to the start of the intervention period. * training adherence of less than 85%.

Keywords: resistance training strength training
low dose tadalafil for treatment of female oab syndrome: short term follow up.

Conditions: Female Patients With Overactive Bladder Syndrome or Female Patients With Urgency or Urgency Urinary Incontinence

Summary: evaluation of use of low dose tadalafil 5 mg daily for treatment of female oab syndrome

90 female patients with overactive bladder syndrome divided into 3 groups group a subjected to daily low dose tadalafil 5 mg ,group b subjected to tolterodine and group c to placebo. they are evaluated as using oab symptoms score for 6 months follow up

Eligibility criteria:
inclusion criteria: * any female with overactive bladder syndrome, urgency with or without urgency urinary incontinence exclusion criteria: * active urinary tract infection * neurologic abnormality * pure stress urinary incontinence
long term follow up of patients who were treated with extracorporeal membrane oxygenation for pandemic influenza a/h1n1 induced severe respiratory failure

Conditions: Long Term Outcome

Summary: patients treated with extracorporeal membrane oxygenation (ecmo) for severe respiratory or circulatory failure show severe long term disability due to impaired lung -, cerebral-, cognitive function and impaired quality of life. this study investigates the long term outcome of all patients who are still alive three years after ecmo treatment for severe respiratory failure during the h1n1 2009 pandemic at the karolinska university hospital.


Eligibility criteria:
inclusion criteria: * survivors of ecmo treatment for influenza a/h1n1 pneumonia during 2009/2010 pandemics at the ecmo center karolinska exclusion criteria: * none

Keywords: ards ecmo h1n1 pandemics
attention-deficit hyperactivity disorder (adhd) study with adults

Conditions: Attention Deficit Disorder

Summary: this is a placebo controlled study evaluating the efficacy and safety of medication in adults with attention-deficit hyperactivity disorder (adhd).


Eligibility criteria:
inclusion criteria: * patient must be diagnosed with adhd. exclusion criteria: * patient has a current or past history of seizure disorder, brain injury, anorexia nervosa or bulimia. * patient has a current diagnosis of major depressive disorder (mdd). * patient has a current primary diagnosis of, or received treatment for, panic disorder, obsessive compulsive disorder (ocd), posttraumatic stress disorder (ptsd) or acute stress disorder within the previous 12 months. * patient has a lifetime diagnosis of bipolar disorder, schizophrenia or other psychotic disorders. * patient has a positive urine test at screening for presence of illicit drugs or alcohol abuse during the past 12 months.

Keywords: add adhd attention deficit hyperactivity
effect of hyponatremia in small cell lung cancer

Conditions: Small Cell Lung Cancer

Summary: in this retrospective study, the investigators determined the frequency of hyponatremia in small cell lung cancer and the prognosis. 126 (27%) of 466 patients were hyponatremic. hyponatremia could not be corrected in 50.8% (n=64) of hyponatremic patients. survival was found to be better in the group of whom hyponatremia was corrected.


Eligibility criteria:
inclusion criteria: patients diagnosed with sclc between january 2012 and january 2017 in our hospital were retrospectively screened exclusion criteria: over 18 age if data doesn't exist

Keywords: small cell lung cancer hyponatremia prognosis treatment biochemistry
comparison of mr elastography methods without and with compressed sensing

Conditions: Liver Diseases

Summary: in this research study, the investigators will compare the liver stiffness results obtained from the current magnetic resonance imaging (mri) method to liver stiffness results obtained from a method that uses faster imaging techniques.

mr elastography is increasingly used to assess liver stiffness in pediatric and adult patients with chronic liver diseases. while numerous tissue abnormalities can affect liver stiffness, liver stiffness measured by mr elastography is most often used to predict and quantify liver fibrosis. conventional mr elastography techniques require multiple breath-holds that are 12-20 seconds in length. in the pediatric population, reliable breath-holding \>10 seconds can be challenging. recently, compressed sensing has become available as a method for accelerating image data acquisition, and thus shortening breath-holds.

Eligibility criteria:
inclusion criteria: * adult volunteers ≥18 years of age * ability to tolerate 30 minutes in an mri scanner. * nothing to eat or drink for 4 hours prior to the mri scan exclusion criteria: * no contraindication to mr imaging (e.g., implanted non-mri compatible device) * known or suspected pregnancy. female subjects of child bearing potential will undergo a urine pregnancy test prior to imaging.
muscle tone changes in acute stroke according to brain injury

Conditions: Stroke

Summary: the purpose of the study is to examine connections between muscle tones, strength and function after stroke.

measurements are intended to repeat every two days in acute phase to discover possible changes in tone and strength in arm and leg muscles.

Eligibility criteria:
inclusion criteria: * unilateral decline in the arm or leg muscle strength exclusion criteria: * unwilling to take part on the trial * not conscious * no differences between muscle strength on the right and left side

Keywords: stroke tone strength
the impact of commercial blenderized formula on caloric needs, gastrointestinal symptoms, and gut microbiome in children with cerebral palsy (cp)

Conditions: Cerebral Palsy

Summary: the purpose of this study is to compare the pediatric quality of life inventory gastrointestinal symptoms scale gastrointestinal symptoms scale (gi-pedsql) differences , to assess the differences in stool microbiome and stool metabolomics , to assess differences in salivary cytokine profile , to assess differences in weight change , to compare the use of antacid medications and to compare the use of laxative medications in patients on commercial formulas (cf) versus commercial blenderized tube feed (cbtf).


Eligibility criteria:
inclusion criteria: * patients with cp receiving \>75% of total daily caloric requirements from commercial formulas (cf) via a gastrostomy tube 12french or greater * patients' insurance covers a cbtf * diagnosis of cerebral palsy exclusion criteria: * receiving enteral nutrition by transpyloric feeds or jejunal tube. * receiving \<75% of total daily energy requirements from a commercial formula * weight or weight for length or body mass index less than the 5th percentile for age or greater than the 85th% percentile for age when plotted on the cerebral palsy growth chart * rapidly progressive neurodegenerative disease diagnosis * use of monomeric formulas

Keywords: blenderized tube feeds (btf) commercial blenderized tube feed (cbtf) commercial formula
a comparison of two doses of pemetrexed in patients who have lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: the purposes of this study are to determine: * the safety of pemetrexed and any side effects that might be associated with it * how much pemetrexed should be given to patients. it is possible that information collected during this study will be analyzed by the sponsor in the future to evaluate pemetrexed for other possible uses or for other medical or scientific purposes other than those currently proposed. although pemetrexed has been shown to be effective in some patients with non-small-cell lung cancer, pemetrexed might not have beneficial effects for all patients.


Eligibility criteria:
inclusion criteria: * diagnosis of locally advanced or metastatic (stage iii or iv at entry) non-small cell lung cancer (nsclc) that is not amenable to curative therapy. * patients must have been previously treated with one platinum-containing chemotherapy regimen for locally advanced or metastatic disease. patients are also eligible if they have received one platinum-based chemotherapy regimen as neoadjuvant or adjuvant chemotherapy, but must have received an additional chemotherapy regimen upon recurrence. * no more than two prior systemic anti-cancer therapies will be allowed. * prior radiation therapy is allowed to less than 25% of the bone marrow. prior radiation to the whole pelvis is not allowed. prior radiotherapy must be completed at least 2 weeks before study enrollment, and the patient must have recovered from the acute toxic effects of the treatment prior to study enrollment. exclusion criteria: * pregnancy. * breast-feeding. * second primary malignancy that is clinically detectable at the time of consideration for study enrollment. * inability to interrupt aspirin, or other nonsteroidal anti-inflammatory agents for a 5-day period. * inability or unwillingness to take folic acid or vitamin b12 supplementation.
clinical and radiographic evaluation in pulpotomy of primary molars using protooth vs. mta

Conditions: Clinical Evaluation Including Pain and Swelling

Summary: the aim of the study is to evaluate the clinical and radiographic success in pulpotomy using novel fast-setting calcium silicate cement (protooth) versus mta in exposed primary molars.


Eligibility criteria:
inclusion criteria: * complete physical and mental health, with no confounding history of systemic disease and/or use of special local or systemic drugs * no allergic reactions recorded in patient history * having primary molar teeth in one jaw, having deep caries and vital pulp. * no history of spontaneous pain, pathologic mobility, draining sinus tract, redness or swelling of vestibule * normal gingival and periodontal condition, with no sensitivity to vestibular palpation, and no pain on percussion test * radiographic criteria: * no sign of radiolucency in periapical or furcation area * no widening of pdl space or loss of lamina dura continuity * no evidence of internal/external pathologic root resorption exclusion criteria: * lack of informed consent by the child patient's parent * lack of informed consent by the child patient's parent * unable to attend follow-up visits. * refusal of participation.

Keywords: pulpotomy , primary molars , protooth , mta
evaluation of prognostic monitoring for women who have completed standard treatment for breast cancer

Conditions: Breast Cancer

Summary: the relationship between immune inflammation-related protein complexes in blood and recurrence or metastasis of breast cancer will be studied.

200 patients with breast cancer will be followed up. peripheral venous blood was collected every 3 to 6 months. change regularity of breast cancer-specific immune inflammation-related protein complexes in blood at different follow-up time points will be studied. the relationship between disease-specific protein complexes and pathological state of patients will be analyzed.

Eligibility criteria:
inclusion criteria: * female * postoperative pathology confirmed invasive breast cancer after surgery for breast tumors * breast cancer-related chemotherapy and radiotherapy completed * axillary lymph node metastasis ≥ 4 * age ≤ 60 years old exclusion criteria: * male * aged above 60 * breast carcinoma in situ * women in pregnancy or breastfeeding * suffering from other malignant tumors * non-compliant patient
rapid pancreatic and ovarian screening mr imaging with motion corrected t1, t2, and advanced diffusion weighted imaging for patients with brca mutation who undergo screening breast mri

Conditions: Screening Breast MRI in Patients Who Are BRCA Mutation Carriers

Summary: the purpose of this study is to create a rapid scan of the pancreas and ovaries that could be used in the future to screen patients at risk for pancreatic or ovarian cancers. currently, magnetic resonance imaging (mri) examinations of the pancreas and ovaries can last 30-45 minutes each. the investigators hope to create a rapid pancreatic and ovarian mri evaluation that can be used as a screening tool that is completed in approximately 15 minutes. they will compare different tools available on modern mri scanners to see which one reliably offers high quality images of the pancreas and ovaries.


Eligibility criteria:
a minimum of 5 and maximum of 60 evaluable patients will be imaged on this study. description of the subject inclusion and exclusion criteria are listed below. inclusion criteria: * brca 1 or 2 mutation * age ≥ 30 * patients scheduled to undergo screening breast mri with contrast exclusion criteria: * patients with known breast cancer * patients unable to complete their scheduled breast mri * patients with prior pancreatic surgery or cancers * patients with prior ovarian cancer or surgery involving removal of one or both ovaries * patients with prior abdominal or pelvic surgery

Keywords: breast mri t1 weighted and diffusion weighted mr screening pancreatic screening ovarian 15-120
pilot-testing a family-based intervention to improve child outcomes and increase family activity

Conditions: Smoking; Overweight; Obesity

Summary: the purpose of this study is to examine the feasibility and acceptability of a family-based program to improve physical activity and tobacco outcomes in a small pilot of middle school students and their families.

low income ethnic minority youth tend to be at greater risk for obesity, physical inactivity, high risk behaviors such as tobacco and substance use and resulting cardiovascular and chronic disease. in this study we modified a tobacco and substance use risk prevention program to develop a tailored intervention (healthy families dc) that also included promotion of physical activity (pa) for dc middle-school students referred by school staff as over-weight and at risk for problem behaviors. the program included an initial family assessment, a family feedback session with family pa goal setting and 6 phone/text based booster sessions. a pilot study with 18 families, comprised of at least one caregiver and target child, was conducted to examine feasibility, acceptability, and trends in preliminary outcomes such as pa via self-report and accelerometry, health risk behaviors (e.g., tobacco use), health goal setting, and changes in family functioning (e.g., youth positive behaviors, parenting).

Eligibility criteria:
inclusion criteria: * students aged 12-16 years * attending regular education classes at three urban dc public middle schools. -students must currently reside with at least one parent or guardian who wishes to also participate in this study. * students and at least one guardian must be fluent in english exclusion criteria: * adolescents, who are outside the study age range * patients/parents unable to speak/read english * are wards of the state * not attending regular education classes at the public middle schools -furthermore, adolescents and guardians not assenting/consenting to be in the study will be excluded.
effect of a vegan mediterranean diet on cardiometabolic biomarkers, functional capacity, and quality of life in patients with fibromyalgia

Conditions: Fibromyalgia

Summary: this study aims to evaluate the effect of a vegan mediterranean diet compared to a traditional mediterranean diet on inflammatory biomarkers, functional capacity, and quality of life in patients with fibromyalgia.

the study involves two visits to the exercise physiology research laboratory at ufv. during the first visit, participants will complete functional capacity tests, respond to questionnaires (fibromyalgia impact questionnaire, short form-36, mdf-fibro-17, and tampa scale for kinesiophobia), and provide a blood sample from the antecubital vein collected by an auxiliary nurse from the eurofins megalabs laboratory. the biochemical markers to be analyzed include: white blood cell count (neutrophils, lymphocytes, monocytes, and platelets), lipid profile, fasting blood glucose levels and acute-phase proteins (c-reactive protein). additionally, body composition will be assessed using a tanita tbf300, and waist circumference will be measured. functional capacity tests will include a handgrip strength test, a 30-second chair-to-stand test, and a timed up-and-go test. participants will undergo a six-week dietary intervention and will return for a second visit at the end of the intervention period. they will be randomly assigned to follow either a vegan mediterranean diet or a traditional mediterranean diet, both of which will be guided and supervised by registered dietitians. these diets will be designed to meet individual energy needs and key nutrient requirements, following the standards set by the national academy of medicine and the academy of nutrition and dietetics. both diets will be isocaloric and maintain an identical macronutrient distribution. after the intervention, participants will repeat the same functional tests, questionnaires, and capillary blood measurements.

Eligibility criteria:
inclusion criteria: * adults aged between 18 and 50 years. * participants with a fibromyalgia diagnosis according to the american college of rheumatology (acr) criteria. * functional independence. * non-smokers. * low alcohol consumption (\<1 serving/day). * pharmacological treatment stabilized for at least 4 weeks prior to the start of the study. exclusion criteria: * pregnant, lactating, or menopausal women. * physical condition that prevents the performance of functional capacity tests. * change in pharmacological therapy during the intervention period. * concomitant inflammatory conditions.

Keywords: fibromyalgia
microenvironmental trial of classical hodgkin lymphoma in adolescents

Conditions: Classical Hodgkin Lymphoma

Summary: background. classical hodgkin's lymphoma (chl) in adolescents between 15 and 18 years shows a higher disease-related mortality and the overall prognosis is worse than both children and adults. objectives. to investigate the immune checkpoint inhibitors (icpi) therapeutic targets and specific t-regulatory and cytotoxic t-cell subsets, in the subgroup of adolescent chl patients and to investigate their prognostic power. methods: retrieved formalin-fixed paraffin-embedded (ffpe) of adolescent patients diagnosed with chl with available clinical and tested by immunohistochemistry the immune checkpoint molecules ctla-4, lag-3, pd-1 and pdl1 and the biological markers foxp3 and cd8.


Eligibility criteria:
inclusion criteria: * patients aged 12 to 18 years at diagnosis of classical hodgkin lymphoma. exclusion criteria: * unavailability/insufficiency of histological material for diagnosis.

Keywords: hodgkin lymphoma adolescent microenvironment immune-check points