Kornimate/medical-research-clean huggingface dataset:
mindfulness-based intervention for people with parkinsonian tremor

Conditions: Parkinson Disease; Rest Tremor

Summary: mindfulness meditation is an approach that has shown interest in treatment of anxiety in parkinson's disease. this pilot study aims to assess a more specific effect on tremor using essential tremor embarrassment assessment and inertial sensors allowing monitoring during sessions and in daily life. this study will focus on 20 patients (10 with and without mindfulness based intervention and will aim to develop the interface and demonstrate proof of concept before setting up a controlled study

methodology: randomized, pilot study comparing 2 parallel arms (mindfullness group versus group with routine care). number of patients:20 patient selection: patients with severe rest tremor duration of project: 12 months schedule visit: 4 visits in 6 months

Eligibility criteria:
inclusion criteria: * parkinson disease * hoehn st and yahr stage \<or = 3 * age between 35 and 85 years old * treatment stabilized for at least 3 months * disturbing parkinsonian tremor of the upper limb (item mds -updrs 2.10\> 1) and lasting 2 to 6 hours per day * patients with internet access exclusion criteria: * presence of disturbing dyskinetic movements (item mds-updrs4.2\> 1) * patient who has already practiced meditation in the last 5 years * untreated major depressive episode * hallucinations (item mds-updrs1.2\> 1)) * psychotic disorders - confusional syndrome * presence of signs in favor of an atypical parkinsonian syndrome (oculomotor impairment, early falls, hallucinations, moca \<20, early dysautonomia) * adult protected by law (guardianship, curatorship or under legal protection) * deprivation of liberty by judicial or administrative decision * high probability of non-compliance with the protocol or abandonment during the study * refusal to sign informed consent * pregnant or breastfeeding woman * lack of social coverage.

Keywords: parkinson disease rest tremor mindfulness based intervention sensors embrassment
study of ketamine for depression in cancer patients receiving palliative care

Conditions: Depression; Cancer; Palliative Care

Summary: this is a phase 2 study of the drug ketamine for the treatment of depression in cancer patients receiving palliative care. the purpose of this study is to see how useful the drug is at decreasing the severity of depression these patients. ketamine will be given through the nose.


Eligibility criteria:
inclusion criteria: * provide written, voluntary informed consent prior to study enrollment. participants must be capable of consenting to treatment as substitute decision makers will not be allowed to consent to the study on their behalf * males and females ≥ 18 years of age * patient is receiving palliative care at princess margaret cancer centre (pm) including all in-patient units and outpatients * meet diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) criteria for major depressive disorder (mdd), with a current major depressive episode (mde) * depression severity must be in the moderate to severe range, as determined by a montgomery-åsberg depression rating scale (madrs) score greater than or equal to 20 * participants must have a confirmed diagnosis of cancer and an estimated life expectancy of less than twelve months, as determined by the palliative care physician exclusion criteria: * presence of delirium or suspected delirium * severe hypertension or severe cardiac decompensation * previous stroke history * history of intolerability, hypersensitivity or allergy to ketamine * patients with bipolar disorder, psychotic disorders, substance use disorders or active suicidality based on a mini-international neuropsychiatric interview (mini) conducted by a delegated physician will also be excluded * current symptoms of psychosis or perceptual disturbances of any kind per investigator discretion * pregnancy or breastfeeding women
pancreatic stump closure after distal pancreatic resection

Conditions: Distal Pancreatic Resections

Summary: the aim of this study is to investigate whether finnish binding pancreatico-jejunal anastomosis is feasible and prevents the risk for post operative pancreatic fistula after distal pancreeatectomy.


Eligibility criteria:
inclusion criteria: * patiens which the distal pancreatic resektions * the type of resections that is techically possible with finnish binding panceatico-jejunal anastomosis exclusion criteria: * if the pancreas is not suitable for this kind of anastomosis

Keywords: pancreas pancreatico-jejunal anastomosis postoperative pancreatic fistulae
efficacy of the co-op approach with brazilian children with developmental coordination disorder

Conditions: Developmental Coordination Disorder

Summary: children with developmental coordination disorder (dcd) have difficulties performing daily activities which reflects negatively on participation, impacting their lives. to date, there are a number of interventions to improve performance of these children on activities they want or need to. in brazil, there is little research on the efficacy of such approaches. our main objective was to start a set of studies to examine the effects of the cognitive orientation to daily occupational performance approach (co-op approach) protocol on occupational performance and satisfaction of brazilian children who have dcd; to examine whether children were able to transfer strategies and skills learned during co-op to untrained goals.

background. children with developmental coordination disorder (dcd) have difficulties performing daily activities which reflects negatively on participation, impacting their lives. objectives. to examine the effects of the cognitive orientation to daily occupational performance approach (co-op approach) protocol on occupational performance and satisfaction of brazilian children who have dcd; to examine whether children were able to transfer strategies and skills learned during co-op to untrained goals. methods. a pre-post group comparison design with eight boys aged 6-10 years old. children participated in 12 co-op sessions with their parents twice a week, with an extra session added to the protocol for parents´ orientation. the canadian occupational performance measure and the performance quality rating scale were used as outcome measures.

Eligibility criteria:
inclusion criteria: * poor motor performance measured by a motor performance test (cut off score below the 15th percentile). * poor performance on academic and daily living activities measured by the developmental coordination disorder questionnaire answered by the parents. * attending regular education with no evidence of marked school delay (over a year). * cognitive development within the expected age range according to the wechsler intelligence scale for children-third edition (wisc-iii). exclusion criteria: * signs of neurological or neuromuscular disorder. * presence of intellectual disability.

Keywords: child goal intervention motor skills disorder occupational therapy
clinical application of 68ga-psma pet in prostate cancer

Conditions: Prostate Cancer

Summary: prostate cancer is the 7th leading cause of cancer death for men in taiwan. it is important to identify the extent of disease extent to deliver adequate treatment, either for primary staging or in recurrence. however, conventional imaging techniques including computed tomography, bone scintigraphy, and immunoscintigraphy with 111in-capromab pendetide are not sensitive or specific enough to detect metastatic or recurrent disease. although more widely applied, magnetic resonance still relies on size and shape criteria. 68ga-psma is a new novel positron emission radiotracer which several preliminary data has shown to be effective of detecting recurrent or metastatic prostate cancer. these studies are confined to a small retrospective european population. in this study we aim to synthesize the novel tracer, find the usefulness of 68ga-psma pet in detecting prostate cancer, including primary staging and recurrence, explore the relationship between imaging and clinical parameters, and seek the possibility of 68ga-psma pet to predict tumor nature and prognosis.

prostate cancer is the 7th leading cause of cancer death for men in taiwan. it is important to identify the extent of disease extent to deliver adequate treatment, either for primary staging or in recurrence. however, conventional imaging techniques including computed tomography, bone scintigraphy, and immunoscintigraphy with 111in-capromab pendetide are not sensitive or specific enough to detect metastatic or recurrent disease. although more widely applied, magnetic resonance still relies on size and shape criteria. 68ga-psma is a new novel positron emission radiotracer which several preliminary data has shown to be effective of detecting recurrent or metastatic prostate cancer. these studies are confined to a small retrospective european population. in this study we aim to synthesize the novel tracer, find the usefulness of 68ga-psma pet in detecting prostate cancer, including primary staging and recurrence, explore the relationship between imaging and clinical parameters, and seek the possibility of 68ga-psma pet to predict tumor nature and prognosis.

Eligibility criteria:
inclusion criteria: * histologically confirmed prostate cancer exclusion criteria: * patients with known malignancy in other organs. * patients with severe claustrophobia or unstable vital sigh * other serious comorbidities evaluated by primary investigator

Keywords: prostate cancer ga-68 psma pet
predictive model for pain after tace

Conditions: Hepatocellular Carcinoma

Summary: the main aim of this study was to analyze the risk factors that helped to predict the pain after transarterial chemoembolization (tace).this was a prospective observational study enrolled all hepatocellular carcinoma (hcc) patients undergoing tace in our hospital. pain score at rest was assessed after tace by the patients themselves using a visual analogue scale (vas). independent variables such as age, gender, tumor location, tumor size and number, drug delivery method and presence of portal vein tumor thrombosis (pvtt) were recorded and analyzed.


Eligibility criteria:
inclusion criteria: * a diagnosis of hcc was confirmed either histologically or based on consistent findings obtained from at least two imaging techniques. exclusion criteria: * patients aged \< 18 year * significant heart or lung dysfunction * use of additional analgesics to relieve pain during tace * cognitive impairment * use of psychiatric medications * drug or alcohol abuse
telemedicine improves pain-related disabilities in following up cancer pain outpatient

Conditions: Pain, Chronic; Cancer Pain

Summary: cancer is the second leading cause of death worldwide, with approximately 18.1 million new cases and 9.6 million deaths reported in 2018. cancer-related pain is experienced by 50-70% of patients, with a higher prevalence at advanced disease stages (66.4%). since the development of who's cancer pain guidelines, several studies have reported good relief of symptoms and suffering for a majority of patients. recent reports suggest that up to 50% of patients still report insufficient pain control. patients with cancer often present with multiple symptoms and functional decline. evidence supports multidisciplinary approaches to address symptoms and suffering, including early palliative care referral from review literatures we found that the telemedicine group had significantly higher quality of life than the usual care group. in addition, the telemedicine group had lower anxiety and depression scores than the usual care group. therefore, we will conduct the non-randomized controlled study of using telemedicine comparing to conventional in-person at opd in hospitalized cancer pain patients. the purpose of this study is to assess the pain interference by using the brief pain inventory (bpi) and to compare between the in-person group and the telemedicine group. to assess the cost-effectiveness of telemedicine for reducing symptoms associated with cancer and its treatment.

the pain interference will be assessed and compared using brief pain inventory from 0-70 between in-person group and telemedicine group at 1 month.

Eligibility criteria:
inclusion criteria: * age older than 18 years old * cancer patients who new visit as out patient at pain clinic, siriraj hospital exclusion criteria: * cannot read and write * confusion * unable to use the 0-10 numerical rating scale (nrs) to rate pain intensity. * unstable clinical presentation
serum retinoic acid induced protein 14 (rai14) and metastasis associated cancer colon -1 (macc-1) in breast cancer

Conditions: Breast Cancer

Summary: 1. measurement of serum levels of retinoic acid induced 14 (rai14) and metastasis associated cancer colon -1 (macc-1) as biomarkers for diagnosis of breast cancer. 2. study their relationship to disease stages and clinicopathological features of bc. 3. compare the diagnostic performance of serum rai14 and serum macc-1 with serum carcinoembryonic antigen (cea) and cancer antigen 15-3 (ca15-3) for diagnosis of bc.

breast cancer (bc) is one of the most prevalent neoplasms and the second leading reason of death from cancer in women. every year approximately 2.3 million new cases of bc are diagnosed worldwide. due to the high impact of this type of cancer, the early detection, early diagnosis and effective treatment, will improve the diagnosis of patients and lower the associated mortality rates. carcinoembryonic antigen (cea) and cancer antigen 15-3 (ca15-3) are the most commonly used serum markers in the diagnosis and follow up of bc, however their clinical applications still remain controversial. retinoic acid induced protein 14 (rai14) is an actin-binding protein which participates in physiological processes such as the regulation of cell polarity and transport of spermatozoa. recent studies showed that rai14 is overexpressed in several malignant tumors with a significant role in the development of tumors . the serum rai14 is a reliable novel marker in the early diagnosis and chemotherapy monitoring of triple-negative bc. metastasis-associated colon cancer-1 (macc-1) is a newly identified tumor marker, first identified in colon cancer tissue as a prognostic indicator and inducer of metastasis .it is located on human chromosome 7 (7p21.1) and shown to be a key regulator of the hepatocyte growth factor-mesenchymal epithelial transition factor( hgf-met) pathway in colon cancer. it is shown that serum macc-1 can be a potential biomarker for diagnosis and progression in patients with bc. there was a strong correlation between macc-1 expression and the clinical and the primary tumor, regional nodes, metastasis (tnm) stages of bc.

Eligibility criteria:
inclusion criteria: 1. patients with benign breast lesions. 2. patients with breast cancer who were confirmed by histopathological studies and did not receive any treatment. exclusion criteria: 1- patients who received chemotherapy or radiotherapy. 2- patients with known other organ malignancy.
inhaled iloprost for suspected covid-19 respiratory failure

Conditions: COVID-19; ARDS, Human; Hypoxemic Respiratory Failure

Summary: acute respiratory distress syndrome (ards) is a type of respiratory failure characterized by the rapid onset of widespread inflammation in the lungs. ards is thought to be the main cause of respiratory failure in covid-19 patients. research is still ongoing to further elucidate the different ards subtypes that may exist in covid-19. it is crucial to find new targets for treatment and support of covid-19 patients with respiratory failure.

the investigators hypothesize that inhaled prostacyclins (iloprost in this study) may improve inflammation and oxygenation in suspected or confirmed covid-19 patients with respiratory failure. research participants: suspected or confirmed covid-19 patients presenting to the emergency department (ed) of intensive care units (icu) with hypoxemic respiratory failure. intervention: inhaled iloprost (tradename ventavis by actelion pharmaceuticals us, inc.) three times daily for 5 days methods: patients will be screened in ed and icu for inclusion and exclusion criteria and then consent will be obtained. the intervention will be started within 48 hours of presentation. baseline parameters on oxygenation, inflammatory markers, hemodynamics will be obtained and followed serially over the period of the intervention. additional data about time to intubation, time on mechanical ventilation, lung mechanics, and need for prone positioning will also be collected. data will be analyzed for percentage improvement in oxygenation (oxygen saturation and pao2/fio2 ratio), trends of inflammatory markers, and hemodynamic stability while iloprost is administered. based on previous studies of iloprost on ards patients, the investigators anticipate an improvement in oxygenation and inflammatory parameters and possible prevention of intubation with shorter mechanical ventilation times. iloprost showed a safe profile with stable hemodynamics during administration.

Eligibility criteria:
inclusion criteria: 1. suspected or confirmed covid-19 patient by pcr 2. o2 saturation =\<92% on 5 or more l/min of o2 by nc or face mask 3. on cpap, hfnc or invasive ventilation 4. enrollment within 48h of onset of hypoxemia exclusion criteria: 1. age \<18 2. pregnancy or positive pregnancy test at the time of screening 3. clinical evidence of left atrial hypertension or known chronic chf 4. persistent hypotension sbp\<85 on presentation 5. mechanical ventilation \>7 days 6. patients who received iloprost treatment for any indication within 48 hours prior to enrollment in the clinical trial or patients who were on thrombin inhibitors, or nitric oxide within the previous 24 h before study randomization are also excluded. 7. patients with contraindication for ilioprost

Keywords: iloprost prostacyclins inhaled nitric oxide pulmonary vasodilators
the effects of integrated face-to-face rehabilitation and telerehabilitation on the well-being of family caregivers

Conditions: Caregivers; Family Caregivers; Informal Caregivers

Summary: this controlled, non-randomized study (n=180) explores how participating in rehabilitation services for family caregivers affects the caregivers' mood, perceived quality of life, perceived burden of family care, and overall health. rehabilitation services for family caregivers funded by the social insurance institution of finland (kela) include two 5-day periods of face-to-face rehabilitation and a 12-week telerehabilitation period, which is based on the own path internet intervention and takes place between the face-to-face rehabilitation periods. the observed changes are compared to participating in two other services: 1) social holidays for family caregivers and 2) kela's rehabilitation services for family caregivers and the family members they are caring for (care recipients).


Eligibility criteria:
inclusion criteria: * family caregiver * being 18 years of age or older * providing daily care for an adult family member * participating in one of following: 1. the kela's integrated face-to-face rehabilitation and telerehabilitation service for family caregivers, 2. the mtlh's face-to-face social holidays for family caregivers or 3. the kela's face-to-face rehabilitation services for family caregivers and care recipients * willingness to participate in the study

Keywords: rehabilitation effects effectiveness telerehabilitation family caregivers informal caregivers family caregivers burden
optimal prophylactic method of venous thromboembolism (vte)

Conditions: Venous Thromboembolism

Summary: this study is to define the optimal method of prophylaxis for patients with gastrectomy in korea and the investigators hypothesized only mechanical method would be enough for preventing vte on perioperative period.

venous thromboembolism (vte) is common and often fatal complication in patients with cancer. gastric cancer is the most frequent cancer in korea. the incidence of vte would be increased in patients with gastric cancer, especially associated surgery. however, the incidence and optimal prophylactic method associated with cancer surgery are not well studied in asian patients. most korean surgeon concerns regarding the increased postoperative bleeding associated with low molecular weight heparin(lmwh)prophylaxis. the incidence and adverse event will be examined to define the optimal prophylactic method of vte in surgical patients with gastric cancer.

Eligibility criteria:
inclusion criteria: * patients diagnosed as gastric cancer * elective and curative under general anesthesia * ecog score 0-2 * asa score 3 or less than 3 * informed consents exclusion criteria: * 2nd primary cancer * vte history within one year * anticoagulation history * allergic to heparin * pregnancy or expected pregnancy

Keywords: gastric cancer vte incidence
effect of increased muscular work during different weaning strategies in critically ill patients

Conditions: Acute Respiratory Failure

Summary: most patients admitted to intensive care units require mechanical ventilation. weaning from assisted/controlled ventilation begins when we recognize that the patient has recovered adeguately from acute respiratory failure. if weaning is delayed, costs are increased, as are the risks of nosocomial pneumonia, cardiac-associated morbility, and death. on the other hand, weaning too soon often results in reintubation, which is associated with complications similar to those of prolonged ventilation. the aim of this trial is to establish an evidence-based approach to weaning and to determine when a patient is ready to be weaned from mechanical ventilation, and what is the best weaning technique.


Eligibility criteria:
inclusion criteria: 1. age higher than 18 yrs 2. pao2/fio2 greater or equal than 150 with peep equal or lower than 10, and minute ventilation lower than 15 l/min 3. temperature lower than 38,5°c 4. stable hemodynamics: hr 60-125 b/min, sbp 90-160 mmhg without or with dopamine lower than 10 gamma/kg/min or dobutamine lower than 10 gamma/kg/min, no acute arrythmias 5. hb higher than 8 g/dl 6. gcs higher or equal than 9 7. the attending physician has to agree that the patient is in stable conditions and ready to be weaned from the ventilator exclusion criteria: 1. presence of chronic neuromuscular diseases 2. need of surgical intervention within the next 72 hours 3. difficult tracheal intubation 4. tracheostomized patients