Kornimate/medical-research-clean huggingface dataset:
an educational self-tracking tool for identification of sars-cov-2 risk transmission

Conditions: Sars-CoV-2 Infection; Empowerment; Transmission

Summary: one way to empower a community, in epidemic control issues, is to know the first-hand screening tools. there are no evaluations of these home-use tools from the perspective of patient and citizen empowerment and participation. the main objective of this study is to analyze whether a self-tracking and self-tracing tool, developed in a participatory way, increases the risk identification of the disease and the empowerment in terms of risk management of transmission by the participants.


Eligibility criteria:
inclusion criteria: fluent in catalan or spanish, resident in catalonia, signs informed consent, commitment to use the tool if he/she gets in intervention group. exclusion criteria: language barrier and other conditions that do not allow self-completion of the survey be a covid case or contact at the time of recruitment.
efficacy and safety of artra (glucosamine plus chondroitin sulfate combination) in treatment of chronic low back pain

Conditions: Low Back Pain

Summary: to study the safety and efficacy of artra (glucosamine chondroitin sulfate) in the treatment of non-specific low-back pain of lumbosacral localization in ambulatory care.

we enrolled patients between 40 and 65 years of age who had low back pain for at least 12 weeks with a pain intensity \>3 on a 0-10 point visual analogue scale (vas). major exclusion criteria were presence of fibromyalgia, degenerative spondylolisthesis, and alcohol and/or drug abuse. all patients were treated with artra (combination of glucosamine hydrochloride 500 mg and chondroitin sulfate 500 mg in tab; unipharm inc.) at a dose of 1 tab bid for the first month and then 1 tab daily for the next two months. the primary endpoint was pain intensity (at rest and movement) as measured on a 0-10 point vas. secondary endpoints included oswestry disability index, patient global assessment of efficacy (0-5 scale) and nsaid consumption.

Eligibility criteria:
inclusion criteria: 1. patients aged 40-65 years, inclusively. 2. pain intensity according to visual analogue scale (vas) \> 3 points. 3. duration of back pain \> 12 weeks. 4. pain reinforcement during movement in lumbar spine. 5. osteoarthritis, spondylarthrosis, osteochondrosis. 6. given written informed consent form for participation in the study. 7. treatment with artra exclusion criteria: 1. history of allergic reactions to chondroprotectors. 2. participation in another clinical study within 30 days before screening or during this study. 3. fibromyalgia. 4. active neoplastic disease, history of neoplastic disease within 3 years before screening. 5. paget's disease. 6. degenerative spondylolisthesis. 7. administration of anticonvulsant, antidepressant, barbiturate, anxiolytic, or muscle relaxant drugs for more than one week prior screening. 8. history of alcohol or drug abuse. 9. frequent episodes of nausea, dyspepsia, pain in the epigastric region, diarrhea, face and extremities edema, dizziness and headache. 10. history of any disease that, in the opinion of the investigator, might confound the results of the study or poses an additional risk to the subject during participation in the study 11. clinically significant renal disorders. -
effects of plant-based meat alternatives in comparison to chicken meat on postprandial metabolism in healthy adults

Conditions: Plasma Amino Acid Appearance and Disappearance; Postprandial Metabolic Events

Summary: the aim of this study is to investigate the postprandial metabolic responses to plant-based meat alternatives made from different protein ingredients (pea, wheat or soy protein) in comparison to chicken in healthy adults. therefore, young healthy subjects consume 4 test meals with 40 g of protein from pea protein, wheat protein, soy protein or chicken in a randomized order. in a postprandial period of 6 hours, parameters of protein, glucose and lipid metabolism (i.a. plasma amino acids), gastric emptying and hunger/satiety are analysed. it is assumed that the plasma amino acid profile after plant protein ingestion differs depending on protein source and in comparison to chicken protein.

in a randomized crossover-design, 20 healthy women and men consume 4 test meals containing either 40 g of protein from plant-based meat alternatives (pea, wheat and soy protein extrudate) or chicken together with 1 g paracetamol, which is used as a marker for gastric emptying. during a postprandial period of 6 hours parameters of protein metabolism (e.g. amino acids in plasma and urine), glucose metabolism (e.g. plasma glucose, serum insulin), lipid metabolism (serum triglycerides, total cholesterol , ldl cholesterol, hdl cholesterol, free fatty acids), serum uric acids, hunger- and satiety-associated gastrointestinal hormones (serum ghrelin, plasma glp-1), and gastric emptying rate (based on plasma paracetamol) are analysed. furthermore, subjective hunger/satiety and acceptance of the meals are assed using visual analogue scales. each intervention arm will be separated by a washout period of at least 7 days.

Eligibility criteria:
inclusion criteria: * non-smoking * metabolically healthy * normal weight (bmi: 18,5 - 24,9 kg/m2) * written informed consent exclusion criteria * pregnancy, lactation * hypo- or hypertension * underweight or overweight/obesity * food intolerances and allergies (especially soy, pea, wheat/gluten) * malabsorption syndromes * gastrointestinal diseases * thyroid diseases * diabetes mellitus type 1 and type 2 * impaired kidney or liver function * anaemia * blood coagulation disorders * irregular menstrual cycle * endometriosis, severe menstrual problems * hormonal contraception * regular use of medications (especially habitual use of paracetamol or medications that may interact with paracetamol) * hypersensitivity to paracetamol * body weight below 50 kg * alcohol abuse * glucose-6-phosphate dehydrogenase deficiency * gilbert\&#39;s syndrome * eating disorders (especially anorexia nervosa, bulimia nervosa) * smoking * participation in another study

Keywords: postprandial metabolic events
vats in patients with advanced ovarian malignancies

Conditions: Ovarian Cancer

Summary: ovarian cancer is the seventh most common cancer and the fifth leading cause of death in women worldwide. about 70% of patients with epithelial ovarian cancer present with advanced disease which will require a combination of cytoreductive surgery and chemotherapy to give them their best chance of long term survival.the presence of macroscopic pleural disease-especially if undetected and unresected after primary debulking surgery-may alter treatment decision-making and markedly affect survival. video-assisted thoracoscopic surgery (vats) allows surgeons, through a minimally invasive approach, to not only drain the pleural effusion but also evaluate macroscopic pleural disease and, when possible, resect gross tumor. few studies reported that vats altered the therapeutic management in ovarian cancer patients leading to an upstaging or down-staging when compared to the ct staging. therefore, this study will prospectively assess the role of vats in the diagnosis and management of supradiaphragmatic disease as well as evaluate the impact of vats findings on the decision of surgical management in patients with advanced ovarian cancer figo (the international federation of gynecology and obstetrics) stage iii/iv.


Eligibility criteria:
inclusion criteria: * figo stage iii/iv ovarian cancer with or without pleural effusion exclusion criteria: 1. previously treated ovarian disease. 2. patient unfit for single lung ventilation. 3. patients with previous lung surgery. 4. patients with possible intrapleural adhesions. 5. patients who had pulmonary resection.

Keywords: ovarian cancer stage iii, iv; vats, ct staging
combination chemotherapy followed by stem cell transplant in high-risk neuroblastoma patients

Conditions: Neuroblastoma

Summary: improvement of event free survival of high-risk neuroblastoma patients by introduction of two additional topotecan containing chemotherapy cycles into the multimodal standard treatment (induction chemotherapy, myeloablative therapy, radiation, surgery as indicated, and consolidation therapy).

experimental intervention (6 weeks + duration of the control intervention): 2 x n8 cycle (topotecan, cyclophosphamide, and etoposide) followed by standard arm treatment (i.e., control intervention) control intervention (total duration 70-76 weeks): 3 x n5 cycle (cisplatin, etoposide, and vindesine) 3 x n6 cycle (vincristine, dacarbacine, ifosfamide, and doxorubicine), myeloablative chemotherapy with autologous stem cell transplantation (melphalan, carboplatin, etoposide) 9 x retinoic acid cycles (6 months, 3 months break, 3 months) supportive care (pcp/fungal prophylaxis, transfusions, antibiotics, g-csf)

Eligibility criteria:
inclusion criteria: * neuroblastoma * stage 4 neuroblastoma and age ≥1 - 21 years or mycn amplification and age ≥6 months - 21 years * informed consent obtained exclusion criteria: * participation in other trials * pregnancy, lactation, or insufficient contraception for girls in childbearing age, * any concomitant non-protocol anticancer therapy, * incomplete initial staging.

Keywords: neuroblastoma chemotherapy autologous stem cell transplantation radiotherapy mibg tumor resection
effects of diaphragm and abdominal muscle training on pft and dyspnea among copd obstructive pulmonary disease patients.

Conditions: Chronic Obstructive Pulmonary Disease

Summary: it will be a randomized control trial at services hospital lahore through convenience sampling technique which will be allocated through simple random sampling through sealed opaque enveloped in to group a and group b . group a: patients will be treated with basic breathing technique whereas group b: will be treated by will be breathing technique along with diaphragm and abdominal training. the study will be completed within 6 months after synopsis approval from ethical committee of rcrs \& ahs . data will be entered and analyzed by spss version 25. after assessing the normality of data , it will be decided either parametric or non-parametric test will be use within a group or between two groups.

chronic obstructive pulmonary disease (copd) is a set of diseases that cause airflow obstruction, breathing difficulties, wheezing and chest tightness. risk factors are smoking and non-tobacco-smoking, the use of biomass fuel and open fires for domestic purposes in poorly ventilated households. physiotherapy is an important component of multidisciplinary therapies. airway clearing, pulmonary rehabilitation, inspiratory muscle training, and non-invasive ventilation is the prior treatment .the aim of this study will be to find the effects of diaphragm and abdominal muscle training on pulmonary function testing and dyspnea among copd patients . it will be a randomized control trial at services hospital lahore through convenience sampling technique which will be allocated through simple random sampling through sealed opaque enveloped in to group a and group b . group a: patients will be treated with basic breathing technique whereas group b: will be treated by will be breathing technique along with diaphragm and abdominal training. the study will be completed within 6 months after synopsis approval from ethical committee of rcrs \& ahs . data will be entered and analyzed by spss version 25. after assessing the normality of data , it will be decided either parametric or non-parametric test will be use within a group or between two groups.

Eligibility criteria:
inclusion criteria: * age group of 35-60 years * moderate copd patients. * cognitive * no previous surgery * clinically stable copd patients with reduced inspiratory muscle strength \[pi and persistent activity-related dyspnea exclusion criteria: * acute attack * severe copd * inability to perform physiological testing * active cardiovascular comorbidity (i.e., severe heart failure with reduced left ventricular ejection fraction, cardiomyopathy, recent acute myocardial infarction, cardiac arrhythmias, or stroke), * unstable * red flags like: fever, night sweats, malaise

Keywords: dyspnea pulmonary function testing diaphragmatic training abdominal training
functional recovery and pain reduction post-hydrodissection vs rehabilitation in patients with carpal tunnel syndrome (hydrocarpal)

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: this study pretend to evaluate the effectiveness of hydrodissection vs only rehabilitation in improving pain and function in patients with cts.

this prospective, longitudinal, randomized in two groups clinical study pretend to evaluate the effectiveness of hydrodissection vs only rehabilitation in improving pain and function in patients with cts, evaluated initially and at 4 and 12 weeks.

Eligibility criteria:
inclusion criteria: * men and women ≥18 years of age, * members referred to and treated at the physical medicine and rehabilitation service of hgr n°1, imss mérida yucatán, and who had a clinical or electrophysiological diagnosis of carpal tunnel syndrome. exclusion criteria: * included a clinical or electrophysiological diagnosis of radiculopathy, plexopathy, polyneuropathy, or other peripheral neuropathy; * current diagnosis of cancer, coagulopathy, thoracic outlet syndrome; * active infectious process or current fracture in the thoracic limb; * previous surgery for carpal tunnel release; * inability to cooperate with filling out scales, physical examination, or infiltration, as clearly detailed.

Keywords: carpal tunnel syndrome rehabilitation physical therapy hidrodissection physiotherapy median nerve neuropathy
the adjustment of doses in diabetes mellitus type i

Conditions: Diabetes Mellitus, Type 1

Summary: the study was carried out in a diabetic patient who was starting a new approach for treatment. previously the patient was treated with novo-mix insulin injection twice per day, the physician decided to change the treatment strategy to be with three doses of novo-rapid insulin injections per day plus one injection of lantus solostar in dinner. for two weeks we were monitoring the blood glucose level by the freestyle libre sensor. moreover, the right statistical technique was used for data analysis.

in this study a diabetic patient is starting a new approach to treatment. previously, the patient received novo-mix insulin injection twice per day (48 units in breakfast \& 28 units in dinner). moreover, the physician decided to change the treatment strategy to be with novo-rapid insulin injection three times per day (36 units in breakfast, 36 units in lunch \& 50 units in dinner) plus one time injection of lantus solostar (50 units) in dinner. thus, for monitoring blood glucose level, we are using the freestyle libre-link. moreover. moreover, freestyle libre sensor continuously measures glucose every time when scanned by the mobile and saves the glucose data in the library. moreover, scanning the freestyle libre sensor with a phone or the reader measures the glucose levels from the interstitial fluid, a thin layer of fluid that surrounds the cells of the tissues in the skin of the patient \[4\]. the scan was done every 1-2 hours for a full glycemic profile.

Eligibility criteria:
inclusion criteria: * diabetic patient exclusion criteria: * normal patient

Keywords: diabetes mellitus, insulin injection, patients training
does preoperative caldolor decrease the requirement for postoperative narcotics

Conditions: Postoperative Pain

Summary: caldolor® is an intravenous (iv) formulation of ibuprofen encompassing analgesic, anti-inflammatory and antipyretic (anti-fever) properties. caldolor® is the first iv antipyretic approved by the us food and drug administration (fda), providing an alternate route for administration of ibuprofen when the oral route is not preferable. recent studies have reported that caldolor® decreases morphine use and pain at rest and with movement compared to patients not receiving this drug. the hypothesis of the proposed study is that a single dose of caldolor® 800 mg given 30 minutes preoperatively for patients undergoing laparoscopic or open inguinal and/or umbilical hernia repair will result in a \>20% decrease in postoperative narcotic use within the first 24 hours and at 7 days, and decreased vas pain score at 2 hours, 1 day, 3 days and 7 days after surgery. the use of less postoperative narcotics has been associated with a faster return of normal bowel function and resumption of normal ambulatory status thus resulting in improved general well being for the patient.


Eligibility criteria:
inclusion criteria: * primary inguinal and/or umbilical hernia repair * age \> 18 years old exclusion criteria: * history of gastrointestinal bleeding * allergy to ibuprofen * creatinine \> 1.5 mg/dl

Keywords: ibuprofen postoperative narcotics visual analog pain scale inguinal hernia repair umbilical hernia repair
autonomic modulation in takotsubo syndrome

Conditions: Takotsubo Syndrome

Summary: this is a minimal risk case-controlled single arm intervention study, including 10 patients with a prior history of takotsubo and 10-age and sex matched healthy controls. subjects will undergo in laboratory testing to measure autonomic function. they will then undergo a 15-week program of device-guided breathing with remote measures of autonomic function obtained at home. analysis will determine the reproducibility of home autonomic measures and the provide preliminary data to determine the efficacy of device-guided breathing on autonomic measures and quality of life in patients with takotsubo.


Eligibility criteria:
inclusion criteria: * confirmed history of takotsubo syndrome * healthy person with no significant past history of cardiovascular or neurological disease such as heart failure or heart attack; people with cardiovascular risk factors such as hypertension will be permitted to participate exclusion criteria: * pacemaker or defibrillator implanted * evidence of autonomic neuropathy, alcohol or drug abuse or exposure to neurotoxins (chemotherapy). * diabetes
compare the efficacy of vitrectomy combined with dexamethasone implant versus with aflibercept in dme patients diagnosed by intraoperative oct (the video study): study protocol for a randomized controlled trial

Conditions: Diabetic Macular Edema; Pars Plana Vitrectomy; Dexamethasone Intravitreal Implant; Intraoperative Optical Coherence Tomography

Summary: diabetic macular edema (dme) is the main cause of severe vision loss in diabetic retinopathy. intravitreal injection of anti-vascular endothelial growth factor (vegf) and ozurdex are two safe and effective ways to treat dme. pars plana vitrectomy is mainly suitable for the treatment of unabsorbed vitreous hemorrhage (vh) and tractional retinal detachment caused by proliferative diabetic retinopathy (pdr). intraoperative optical coherence tomography (oct), a diagnostic device, can be used to evaluate the potential condition of the retina. many patients with pdr have unclear refractive stroma due to vh and other reasons, so preoperative oct cannot give a clear diagnosis, so the use of intraoperative oct can judge whether the patients are complicated with dme and give corresponding treatment. the purpose of this study is to explore the prognosis of patients with dme diagnosed by oct during ppv and treated with ppv combined with aflibercept or ppv combined with ozurdex, and to observe and compare the postoperative anatomical results, functional results, times of reinjections and the occurrence of adverse events between the two groups, in order to provide accurate treatment for patients, reduce the frequency of postoperative vitreous injection and lighten the burden of patients.


Eligibility criteria:
inclusion criteria: * ≥18 years of age; * patients and their families fully understand the research and must sign an informed consent form; * patients have a history of diabetes and were diagnosed with pdr by ophthalmic examination; * haemoglobin a1c (hba1c) levels of \<10% within 3 months; * no contraindication of vitrectomy; * pseudophakia or this operation is combined with phacoemulsification and lens implantation; * diagnosed with dme by intraoperative optical coherence tomography during vitrectomy exclusion criteria: * the follow-up period is less than 6 months; * patients need gas or silicon oil tamponade; * patients with rubeosis iridis, neovascular glaucoma and endophthalmitis; * patients with other intraocular surgeries (except cataract surgery with no ruptured posterior lens capsule); * patients with other retinal diseases (i.e., age-related macular degeneration, retinal vein occlusion); * patients received intravitreal ozurdex three months prior to screening or anti-vegf injection one month prior to screening; * patients with uncontrolled systemic disease
congenital hepatic fibrosis and autosomal recessive polycystic kidney disease in children at sohag university hospital

Conditions: Congenital Hepatic Fibrosis and Autosomal Recessive Polycystic Kidney Disease in Children at Sohag University Hospital

Summary: polycystic kidney disease is aherditary disorder characterized by the formation of numerous fluid filled cysts in the kidneys which can lead to progressive renal impairment pkdencompasses aspectrum of disorders with autosomal dominant polycystic kidneydisease and autosomal recessive polycystic kidney disease being the two main types


Eligibility criteria:
inclusion criteria: * pediatric patients aged 0-18 years both male and female patients exclusion criteria: * patients whose guardians dont provide informed consent patients who are not complient with follow up vists and data collection protocols
evaluation of the istent versus two ocular hypotensive agents in patients with primary open-angle glaucoma (poag)

Conditions: Eye Diseases; Glaucoma, Open-Angle; Glaucoma

Summary: prospective, unmasked, randomized evaluation of the istent in patients with primary open-angle glaucoma. patients will be randomized to one of two groups: 1) istent, or 2) medication.

two hundred patients will be enrolled in the study at up to 21 clinical sites; follow-up is through 1 year.

Eligibility criteria:
inclusion criteria: * diagnosis of primary open-angle glaucoma * male or female at least 18 years of age and able to provide written informed consent * mean iop (at baseline visit after washout of any medications) must be 22 mm hg and no greater than 38 mm hg * likely to be available and willing to attend follow-up visits exclusion criteria: * angle closure glaucoma * secondary glaucomas * prior glaucoma procedures * elevated episcleral venous pressure from history of active thyroid orbitopathy, carotid-cavernous fistula, orbital tumors, or orbital congestive disease

Keywords: primary open angle glaucoma (poag) oag glaucoma