Kornimate/medical-research-clean huggingface dataset:
antibiotic prophylaxis in open fractures

Conditions: Open Fractures

Summary: prospective look at antibiotic prophylaxis with ceftaroline in patients with type ii and iii open fractures

determine if antibiotic prophylaxis with ceftaroline in patients with type ii and iii open fractures is a safe and effective alternative to standard combination therapy

Eligibility criteria:
inclusion criteria: * male or female \>= 18 years old * complete an informed consent * patients are diagnosed with a type ii or iii open fracture exclusion criteria: * allergy to beta-lactam antibiotics prior to screening * prior to enrollment: patients received 3 or more doses of antibiotic prophylaxis * pregnant female * inability to provide consent
comparison of trunk muscle performance between sprinters with and without hamstring strain injury history

Conditions: Hamstring Injury

Summary: the aim of this study is to: 1. compare trunk muscle performance between sprinters with and without hsi history 2. investigate whether running speed influences the differences on trunk muscle activity between these two groups

hamstring strain injury is one of the most common injuries in the lower extremities. as running speed increases, the force and load on the hamstring muscles significantly increase, thereby increasing the risk of injury. trunk muscles are connected thigh muscles through the pelvis, and poor trunk muscle capacity of maintaining stability affect the muscle length of the lower limbs during movement, reducing their contractile tension and increasing the risk of injury. earlier literature also indicated that poor trunk muscle performance is related to the occurrence of lower extremity sport injuries. however, literature on the relationship between trunk muscle performance and hamstring strain injury is scarce. testing methods of existing research have failed to fully reflect the actual circumstances of sprinting. moreover, previous studies have predominantly focused on soccer players. however, the running mechanics of soccer player and sprinter are slightly different. currently, there is lack of research investigate the relationship between trunk muscle performance and hamstring strain injury in sprinters.therefore, the aim of this study is to: (1) compare trunk muscle performance between sprinters with and without hsi history, (2) nvestigate whether running speed influences the differences on trunk muscle activity between these two groups

Eligibility criteria:
inclusion criteria of hsi history group: * have ≥ twice hamstring strain injury occurrence in the past year inclusion criteria of control group: * without any hamstring strain injury occurrence in the past year * match gender, age, bmi, dominant side, training experience, training frequency, personal best record in 100m with hsi history group exclusion criteria of all subjects: * neurological, cardiorespiratory or systemic disorder * have low back pain history in the past year * scoliosis * sacroiliac joint dysfunction * complaints of pain on trunk \& lower extremity * leg length difference \> 2cm * history of lower extremity surgery

Keywords: hamstring strain injury trunk muscle performance hip muscle performance sprinter
evaluation of the dcis score for decisions on radiotherapy in patients with low/intermediate risk dcis

Conditions: DCIS

Summary: to evaluate whether the use of the oncotype dx dcis score can guide delivery of radiation in women with low to moderate risk dcis who have had breast conserving surgery

a prospective cohort study, conducted in canada, to evaluate whether the use of the dcis score changes the treatment recommended and the treatment received in women with low to moderate risk dcis following breast conserving surgery who are candidates for radiation therapy. we plan to study 280 eligible, consenting women who will have their tumour tissue specimen sent to genomic health to assess their dcis score. at each centre, all patients with dcis referred to radiation oncology will be documented. when a physician identifies an eligible patient, the patient will be approached by the referring physician or delegate to voluntarily provide informed consent to participate in this study. consenting patients will be registered through the ontario clinical oncology group's (ocog) web-based registration system. data related to the patient demographics, surgery details, and tumour characteristics will be collected. the preliminary treatment recommendation and patient preference for treatment will be documented. patient decisional conflict will be documented by the patient using the decisional conflict scale (dcs). the patient's tumour specimen will be sent for analysis to genomic health. dcis score results will be sent to the referring physician. ocog will also receive the dcis score results. the final treatment recommendation, patient preference, and treatment received by the patient will be documented. patient decisional conflict will be documented by the patient using the dcs. the study data will be verified by source documentation.

Eligibility criteria:
inclusion criteria: (1) women with newly diagnosed breast cancer treated by definitive surgery with histological evidence limited to dcis. exclusion criteria: 1. age \< or = 45; 2. treated by mastectomy; 3. surgical margins of \<1mm;(re-excisions may be performed where results are regarded as clear margins, these cases will not exclude patients); 4. tumour size \>2.5cm; 5. any invasive breast cancer including micro invasion; 6. histological evidence of multifocality (defined as having more than one distinct focus of dcis with \>5mm of intervening benign breast tissue in one quadrant of the breast); 7. any associated lobular carcinoma in situ; 8. previous diagnosis of ipsilateral invasive carcinoma or dcis of the breast; 9. any contraindication for whole breast irradiation such as chronic heart or lung disease or previous ipsilateral chest wall radiotherapy; 10. physician/patient unwilling to comply with study protocol; and 11. inability to provide informed consent (e.g. dementia or severe cognitive impairment).

Keywords: ductal carcinoma in situ dsc breast conserving surgery
hydrocortisone use after etomidate in intensive care

Conditions: Patient Admitted in Reanimation

Summary: the objective of the study is to assess the value of substitution with 200mg/24h of hydrocortisone for 48 hours for patients in intensive care who have received a single injection of etomidate

etomidate is a hypnotic widely used for patients in intensive care who require rapid induction, because of its short duration of action, its excellent cardiovascular tolerance and maintenance of cerebral perfusion pressure. for this reason etomidate remains the hypnotic of choice for induction of unstable patients. other hypnotics currently in existence do not provide adequate safety with a sufficiently predictable and stable effect in this situation. however, it may induce acute adrenal insufficiency by inhibition of 11-b-hydroxylase necessary for the synthesis of cortisol from compound s. an observational study conducted at the grenoble university hospital in 2006 showed that the duration of this blockage can reach up to 48 hours. acute adrenal insufficiency in intensive care patients is associated with a poor prognosis. the main objective of this study is to assess the value of substitution with 200mg/24h of hydrocortisone for 48 hours for patients in intensive care who have received a single injection of etomidate. this is an interventional, prospective, randomized, placebo-controlled, double-blind, analytical study with a cohort of 100 patients between 18 and 80 years, of both sexes, who have had tracheal intubation in a pre-hospital or shock treatment setting with the administration of a single injection of etomidate.

Eligibility criteria:
inclusion criteria: * patients who received an unique injection of etomidate in pre-hospital situation or at "déchocage" in the previous 6 hours. * informed consent signed by the patient or the reliable person * affiliation to a regime of social security exclusion criteria: * persons aimed at the articles l. 1121-5 à l. 1121-8 of the french code of public health * toxic shock requiring a treatment by hshc inn accordance with the criteria of annane et al. \[13\] * purpura fulminans * chronicle suprarenal insufficiency * patients likely to present an acute suprarenal insufficiency : current treatment with antifungal : ketoconazole or fluconazole, known hiv infection, sheehan syndrome * corticotherapy in the 6 last months * initiation of hydrocortisone therapy out of the study * survival estimated at less than 48 hours * no benefits of social security * refusal to participate by patient or reliable person

Keywords: shock tracheal intubation reanimation suprarenal insufficiency etomidate adrenocorticotropic hormone hydrocortisone
short term effect of kinesiotaping in patients with shoulder impingement syndrome

Conditions: Kinesiotape; Exercise; Ultrasound

Summary: we aimed to investigate the effect of kinesiotaping on pain, functionality and ultrasound parameters in patients with shoulder impingement syndrome (sis).

a total of 75 patients with sis were randomly classified into the following three groups: kinesiotaping (kt), exercise (ex) and sham-kinesiotaping (sham-kt). each group was underwent two weeks treatment program. the patients were then evaluated in terms of pain analyzed using the visual analog scale (vas), joint range of motion, quick-disabilities of the arm, shoulder and hand (q-dash) questionnaire before and after treatment. in addition, supraspinatus tendon (sst) thickness and acromiohumeral distance (ahd) parameters were measured using ultrasonography (us). all parameters were measured before and after treatment.

Eligibility criteria:
inclusion criteria: * at least three positive results in the hawkins-kennedy, neer, empty can, drop-arm, and lift-off tests * magnetic resonance imaging findings * age between 45 and 70 years exclusion criteria: * patients who received physical therapy for the shoulder region within the past three months or those with a history of injections to the shoulder joint, * cervical pathologies, * clinical conditions accompanied by neuromotor or sensory dysfunction, * history of malignancy, * pregnancies, * partial or total rupture in the supraspinatus tendon, * adhesive capsulitis, * diabetes or chronic liver, or kidney failure

Keywords: kinesiotape exercise ultrasound
safety assessment of concurrent radiotherapy and novel systemic therapy for breast cancer

Conditions: Breast Cancer, Familial Male; Radiotherapy; Complications; Chemotherapeutic Toxicity; Immune Checkpoint Inhibitor; CDK4/6 Inhibitor; Trastuzumab; Pertuzumab; PARP Inhibitor

Summary: radiation therapy is a crucial part in the comprehensive treatment of breast cancer. in recent years, emerging systemic treatment regimens such as her 2 inhibitors, cdk 4/6 inhibitors, parp inhibitors, capecitabine and pd1 inhibitors have greatly improved the prognosis of breast cancer and has become the standard treatment for specific populations. a considerable number of patients require both radiotherapy and maintenance systemic therapy. however, it is not clear whether systemic therapy should be synchronized or suspended in radiotherapy，despite that previous basic research shows that some molecular drug therapy and radiotherapy has a clear synergy mechanism. there is an agent need for a definite evidence to evaluate the safety of synchronous treatment, to support clinical diagnosis and treatment and the next step of comprehensive treatment. the implementation of the new radiotherapy technology represented by imrt takes into account the prescription dose homogenization and the minimization of normal tissue dosage, which provides a certain basis for the combination therapy. based on the above conditions, this study intends to enroll patients between 18 and 70 years old with chest wall / breast ± lymphatic drainage area and requiring capecitabine, cdk 4/ 6 inhibitor, her2 targeted therapy or immunotherapy. radiation and novel systemic therapies would be delivered concurrently. the study aimed at evaluating the safety of combined treatments.


Eligibility criteria:
inclusion criteria: ecog 0-2. aged 18-70 years old. pathologically diagnosed as breast cancer. need to receive radiotherapy according to guidelines. radiotherapy target volume included chest wall/breast with or without lymph node regions. need to receive one of the following therapies according to guidelines, capetabine, cdk4/6 inhibitor, parp inhibitor , icis , her2 inhibitors. exclusion criteria: male breast cancer. allergy to the upper medicines before. will receive trastuzumab alone during and/or after radiotherapy. with severe other disease.

Keywords: breast cancer radiotherapy adverse events capecitabine trastuzumab pertuzumab immune checkpoint inhibitor cdk4/6 inhibitor parp inhibitor
neuroimaging mao-b in medication free tr-mdd using novel tracer

Conditions: Major Depressive Disorder

Summary: the purpose of this study is to determine if monoamine oxidase b (mao-b) total distribution volume (vt), after phenelzine treatment and if so to what extent.

subjects will receive a pet and mri scan before and after treatment with phenelzine.

Eligibility criteria:
inclusion criteria: * 18-80 years of age * good physical health * diagnostic and statistical manual of mental disorders (dsm-iv) diagnosis of current major depressive episode (mde) * dsm-iv diagnosis of major depressive disorder (mdd) verified by scid for dsm-iv and a psychiatric consultation * greater than 17 on the 17 item hdrs (hamilton depression rating scale). * history of non-response to several different antidepressant classes exclusion criteria: * herbal, drug or medication use (that affect cns function) * suicide attempts * drug or medication use within eight weeks (+5 half lives of medication) * history of substance abuse or any neurotoxin use * history of psychotic symptoms * history of central nervous system (cns) medical illness * current substance abuse * test positive on pregnancy test (for women)

Keywords: depression positron emission tomography (pet) mao-b
study evaluating desvenlafaxine succinate sustained-release tablets (dvs sr) in the treatment of child and adolescent outpatients with major depressive disorder

Conditions: Depressive Disorder, Major Depressive Disorder

Summary: the primary purpose of this study is to evaluate the long-term safety and tolerability of desvenlafaxine succinate sustained-release (dvs sr) in child and adolescent outpatients with major depressive disorder. a secondary aim is to evaluate the efficacy of dvs sr in the treatment of child and adolescent outpatients with major depressive disorder in an exploratory manner.


Eligibility criteria:
inclusion criteria: * outpatients who have completed 8-weeks of treatment in the preceding study, 3151a6-2000, and who, in the opinion of the investigator, would benefit from long-term treatment. * study participants who are not surgically sterile or postmenopausal must agree and commit to the use of a reliable method of birth control for the duration of the study and for 15 days after the last dose of test article. sexually active study participants must agree and commit to the use of condoms in addition to other contraceptive methods. exclusion criteria: * clinically important abnormalities on baseline physical examination or any clinically significant abnormality on electrocardiogram (ecg), laboratory test results, or vital signs recorded before the final study day (day 56 visit) of the preceding study 3151a6-2000. * unresolved clinically significant adverse events or serious adverse events in the preceding study 3151a6-2000. * poor compliance with the preceding study 3151a6-2000, as assessed by the investigator and the medical monitor. * other exclusion criteria apply.

Keywords: mdd depression pediatrics major depressive disorder
optimal timing for tracheostomy in invasively mechanically ventilated covid-19 patients

Conditions: COVID-19

Summary: tracheostomy is a medical procedure performed on the front of a persons neck. it is used to create a connection between the persons trachea and a mechanical ventilator instead of using a tube going through the mouth into the trachea, oral intubation. living with a tracheostomy tube is less stressful compared to oral intubation and facilitate being awake and the start of training on spontaneous ventilation in mechanically ventilated patients. studies of the timing of tracheostomy are either severely affected by methodological bias of to small to determine an effect. thus, it is not known what the optimal timing of the tracheostomy is in mechanically ventilated covid-19 patients.

hypothesis it is hypothesised that timing of tracheostomy to day 9-11 is independently linked to a higher number of days, alive without invasive mechanical ventilation and several secondary outcomes when adequate methods to neutralize waiting time and immortal time bias are used. data sources existing data provided for another project will be used. statistical methods: a cohort study with a target trial emulation (1) on a dataset with cloned individuals assigned to different treatment strategies (i.e. tracheostomy at different timings). censoring at deviation from assigned strategy or death (2). adjustment for confounding will be used.

Eligibility criteria:
inclusion criteria: * adult * admitted to an intensive care unit in sweden from 2020 to 2021 * main discharge diagnosis covid-19 (icd-10, u07.1) * invasive mechanical ventilation exclusion criteria: * no swedish personal identification number.

Keywords: critical care tracheostomy mechanical ventilation
inspiratory muscle strength training to improve blood pressure and physiological function

Conditions: Hypertension; Prehypertension; Aging

Summary: the purpose of this study is to assess the efficacy of inspiratory muscle strength training for lowering blood pressure and improving physiological function (vascular, motor, and cognitive) in middle-aged and older adults with elevated systolic blood pressure.

over, the proposed research project has the long-term potential to influence clinical practice by establishing a novel lifestyle intervention for treating multiple domains of age- and hypertension-associated physiological dysfunction and thereby reducing the risk of clinical disease and disability.

Eligibility criteria:
inclusion criteria: * ability to provide informed consent * willing to accept random assignment to condition * women will be confirmed as postmenopausal (either natural or surgical) based on cessation of menses for \>1 year. * resting systolic blood pressure 120-159 mmhg * resting diastolic blood pressure \<100 mmhg * subjects taking anti-hypertensive medications will be included provided they meet the other inclusion criteria, including elevated systolic blood pressure. these medications will not be withheld prior to experimental protocols. * free from alcohol dependence or abuse, as defined by the american psychiatry association, diagnostic and statistical manual or mental disorders (dsm-iv) exclusion criteria: * current smoking * chronic clinical disease (e.g., inflammatory bowel disease/irritable bowel syndrome, coronary artery/peripheral artery/cerebrovascular diseases, diabetes, chronic kidney disease requiring dialysis, neurological disorders or diseases that may affect motor/cognitive function \[multiple sclerosis, parkinson's disease, polio, alzheimer's disease, dementia, or other brain diseases of aging\]), except hypertension * postmenopausal \<1 year * scoring \<21 on the mini-mental state examination * moderate or sever peripheral artery disease (ankle-brachial index 0.7) * taking a medication that your doctor deems unsafe to hold for \>1 week * a graded exercise test will be performed by all subjects. if there is physician concern or an adverse event, the subject will not participate in the study. * no weight stable in the prior 3 months (\>2 kg weight change) or unwilling to remain weight stable throughout study (rationale: recent weight change or weight loss can influence vascular function)

Keywords: inspiratory muscle strength training
intervetional lay open and curettage versus endoscopic (e.p.si.t) method in the treatment of sacrococcygeal pilonidal sinus disease

Conditions: Endoscopic Pilonidal Sinus

Summary: aim of the work to compare lay open technique versus endoscopic pilonidal sinus treatment as regards recurrence rate, operative data, postoperative pain, intra and postoperative complications, healing time and return to daily activity

introduction pilonidal sinus is a very common inflammatory disease of gluteal region (mccallum et al., 2008). its incidence is 26/100,000 and it usually occurs in working males of age 15 to 30. the disease itself dates back to 1833 when herbert mayo, british physiologist, anatomist and surgeon described it as a sinus containing hair follicles located in the sacrococcygeal region in a woman.

Eligibility criteria:
inclusion criteria: * adult patients of both genders with symptoms from sacrococcygeal pilonidal sinus were included in our study. exclusion criteria: * abscess formation 2. immunodeficiency. 3. patients with congenital asymptomatic pits. 4. patient with psychiatric disease disabling surgical intervention. 5. pregnant females
the effect of mobilization protocol assisted with simulated clinical immersion videos on patients undergoing lumbar spine surgery

Conditions: Lumbar Spine Surgery; Lumbar Disc Herniation

Summary: this study focused on examining the effect of mobilization protocol assisted with simulated clinical immersion videos on postoperative pain, fear of movement, mobility level and satisfaction in patients undergoing lumbar spine surgery.

background: the medical condition that creates the need for lumbar spine surgery causes pain and movement restriction in patients. ensuring safe mobilization in patients with lumbar spine surgery is important for pain management and prevention of complications. aim: in this study, it was aimed to examine the effect of mobilization protocol assisted with simulated clinical immersion videos on postoperative pain, fear of movement, movement level and satisfaction. study design: the study was designed as interventional, pre-test, post-test, parallel group, single-blind, randomized, controlled and experimental. in the study, patients in the control group will be applied routine protocols, and patients in the intervention group will be trained on the day before surgery using the mobilization protocol assisted with simulated clinical immersion videos. in this study, the patients will be distributed to the groups by the "block randomization method". methods: in this study, pain, fear of movement, movement level and satisfaction will be recorded at the first postoperative mobilization and discharge.

Eligibility criteria:
inclusion criteria: * according to the icd-10 codes: those with s33.0-traumatic rupture of lumbar intervertebral disc, g55-nerve root and plexus compressions, m54.4-lumbago with sciatica, underwent lumbar disc herniation surgery (microdiscectomy) due to diagnosed with m54.5-low back pain, * aged 18 and over, * with no hearing, vision, comprehension and speech impairments, * volunteering to participate in the research, * using a smartphone will be included in the study. exclusion criteria: * those under the age of 18, * underwent revision lumbar spine surgery, * with mental or physical disabilities to receive the mobilization training that will be provided before the operation will not be included in the sample.

Keywords: mobilization nursing spinal surgery pain fear of movement patient satisfaction simulation