Kornimate/medical-research-clean huggingface dataset:
effects of lean pork loin intake on protein homeostasis and glucose regulation in prediabetic adults

Conditions: Hyperglycaemia (Non Diabetic); Prediabetes

Summary: we will be directly comparing a high-quality protein diet composed primarily of lean pork loin (pork) to a lower-quality plant-based protein diet (plant) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.


Eligibility criteria:
inclusion criteria: * 1. males and females ages 40-60 years. * 2. bmi 25 to ≤40 kg/m2 (or body fat % ≥25% in males or ≥36% in females) * 3. capable of providing informed consent. * 4. covid-19 negative and/or asymptomatic. * 5. willing to abstain from drinking alcohol or consuming marijuana and cbd products during the 4-day study meal period * 6. hba1c: 5.7-6.4% exclusion criteria: * 1. participant who does not/will not eat animal protein sources. * 2. allergy to wheat, soy, or common ingredients in plant-based protein products. * 3. body mass index \ 40 kg/m2. * 4. hemoglobin \<10g/dl at screening. * 5. platelets \<150,000/ul at screening. * 6. history of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment. * 7. history of gastrointestinal bypass/reduction surgery. * 8. pregnant or lactating individuals. * 9. history of a chronic inflammatory disease (e.g. lupus, crohn's disease) * 10. currently receiving androgen (e.g., testosterone) or anabolic (e.g., gh, igf-i) therapy. * 11. currently using prescription blood thinning medications. * 12. currently using corticosteroid medications (cortisone, hydrocortisone, prednisone, etc.). * 13. unable or unwilling to suspend aspirin use for 7 days prior to visit 3 and visit 7. * 14. unwilling to avoid using protein or amino-acid supplements during participation. * 15. unwilling to fast overnight. * 16. unwilling to avoid alcohol, marijuana and cbd products for the four study days. * 17. currently receiving gip-1 or glp-1 therapy (excluding semaglutide, see below) * 18. participants on semaglutide for \<3 months or with less than one treatment dose (injection) every two weeks

Keywords: lean pork muscle protein synthesis protein plant-based
validation of the english version of the drug hypersensitivity quality of life questionnaire

Conditions: Drug Hypersensitivity; Quality of Life

Summary: we aim to validate the english (uk) translation of the drhy-q, and test its reliability in the uk population. this will facilitate for the subsequent economical evaluation of penicillin allergy delabelling. this research project is part of an msc in allergy undertaken by the principal applicant, dr patricia romero, supervised through imperial college london. target population are patients with a drug allergy diagnosed by an allergist prospectively at the drug allergy clinic. is the english version of the drug hypersensitivity quality of life questionnaire suitable to be used in the uk population?


Eligibility criteria:
inclusion criteria: * • age \>18 years * ability to read english and consent. * confirmed diagnosis of a drug hypersensitivity reaction. * written informed consent exclusion criteria: * • \< 18y/o. * not able to read english. no mental capacity to consent or unwilling to consent. * unconfirmed diagnosis of a drug hypersensitivity reaction.
a study to evaluate nivolumab in japanese participants with muscle-invasive urothelial carcinoma

Conditions: Muscle-invasive Urothelial Carcinoma

Summary: the purpose of this study is to evaluate the effectiveness, safety, and actual treatment status of nivolumab administered as an adjuvant treatment for participants with muscle-invasive urothelial carcinoma (miuc), including bladder, renal pelvis, and ureteral cancer, in a japanese real-world clinical practice.


Eligibility criteria:
inclusion criteria: * must have a histologically definitive diagnosis of miuc at each study site and who must have received nivolumab after radical resection * must present at least once to the study site after nivolumab treatment or must have survival data exclusion criteria: * participants who underwent only partial resection for miuc * participants treated with chemotherapy, radiotherapy, biologics (anticancer agents), intravesical chemotherapy, or bacillus calmette-guérin therapy from the time of radical resection of miuc to the start of nivolumab * participants previously treated with immune checkpoint inhibitors prior to nivolumab treatment other protocol-specific inclusion/exclusion criteria apply.

Keywords: uc nivolumab utuc
perinatal and psychological correlates of neurodevelopmental disorders in children.

Conditions: Perinatal Condition; Neurodevelopmental Disorders; Social Functioning; Child Development; Adolescent Development

Summary: the goal of this observational study is to investigate perinatal, cognitive and social-emotional correlates of neurodevelopmental disorders and educational difficulties in children and adolescents. the study group consist of minimal 500 childrens over 5 years of age who will be examined by qualified diagnosticians. participants will be evaluated with tasks related to the studied variables: cognitive functioning, social-emotional functioning. furthermore informations regarding social-emotional functioning of children, will be collected from parents and teachers. the main questions it aims to answer are: 1. is there a relationship between perinatal factors and the risk of occurrence of neurodevelopmental disorders and/or learning difficulties? 2. is there a specific pattern of cognitive functioning in children and adolescents with indicated neurodevelopmental disorders and/or learning difficulties? 3. is there a specific pattern of social-emotional functioning in children and adolescents with indicated neurodevelopmental disorders and/or learning difficulties? 4. do gender and age moderates specific patterns of cognitive and social-emotional functioning in the studied groups? researchers will compare the following groups of children over 5 years old: 1. with perinatal risks factors 2. with neurodevelopmental disorders: 1. developmental learning disorder 2. disorder of intellectual development, mild 3. attention deficit hyperactivity disorder 4. autism spectrum disorder 3. with learning difficulties 4. control group


Eligibility criteria:
inclusion criteria for neurodevelopmental disorder groups: * age between 5 to 18 y.o. * diagnosed neurodevelopmental disorders, depending on the study group: 1) developmental learning disorder; 2) disorder of intellectual development, mild; 3) attention deficit hyperactivity disorder; 4) autism spectrum disorder inclusion criteria for learning difficulties: * age between 5 to 18 y.o. * difficulty in reading and/or writing without a diagnosis of developmental learning disorder inclusion criteria for control group * age between 5 to 18 y.o. * without a diagnosis of any neurodevelopmental disorder exclusion criteria for learning difficulties - diagnosis of developmental learning disorder exclusion criteria for all groups: * age below 5 y.o. and equal to or above 19 y.o. * diagnosis of any neurodevelopmental disorders

Keywords: hypoxia dyslexia mild intellectual disability adhd asd learning difficulties social-emotional functioning
effects of core strengthening with resistive versus non-resistive diaphragmatic training on core endurance in lower cross syndrome

Conditions: Lower Cross Syndrome

Summary: this study is a randomised control trial and the purpose of this study is to determine the effects of core strengthening on trunk endurance after core strengthening with resistive versus non-resistive diaphragmatic training in lower cross syndrome.

the purpose of this study is to determine the effects of core strengthening on trunk endurance after core strengthening with resistive versus non-resistive diaphragmatic training in lower cross syndrome. core stability of young adults (age: 19-30 years) will be determined using mcgill's muscular endurance test battery: 1. flexor endurance test 2. extensor endurance test 3. right lateral endurance test 4. left lateral endurance test scores will be taken three times for each test; the average of each text will be noted for each participant. data collection procedure: participants of interest would be approached and explained about the research. informed written consent will be taken. recruited participants will be allocated to either of the groups through a sealed opaque envelope method. mcgill's torso muscular endurance test battery will be used and baseline and post-intervention scores will be recorded.

Eligibility criteria:
inclusion criteria: * age 19-30 years * both genders * positive modified thomas test * positive prone hip extension strength test * positive trunk flexion strength test * tight erector spinae * asia pacific bmi normal and overweight (18.5-24.9 kg/m2) * local intermittent lumbar pain * mild to moderate pain (nprs 1-6) * painless movement and activity * pain only produced by sustained loading in relevant position, which is then relieved on moving from that posture exclusion criteria: * shoulder pain * acute flare lbp * centralization and peripheralization of pain (21) * intermittent pain at limited end range (21) * leg symptoms when walking, eased in flexion (signs of stenosis) (21) * pain due to repetitive movement (21) * paresthesia/numbness (21) * structural deformity (kyphosis, lordosis, scoliosis, spondylosis, spondylolysis, spondylolisthesis) * curve reversal (21) * pregnancy * post surgery * degenerative and inflammatory spinal diseases
evaluation of breast cancer surgical margins using optical spectroscopy

Conditions: Breast Cancer

Summary: this study will apply optical spectroscopy to intraoperative margin assessment during surgery for breast cancer. we hypothesize that a combination of fluorescence spectroscopy and diffuse reflectance spectroscopy will reliably detect involved surgical margins. twenty patients with ductal carcinoma in-situ will undergo a standard lumpectomy followed by scanning with a sterile optical spectroscopy probe. frozen sections from the surgical cavity will be used to evaluate the margins. optical spectroscopy data will be categorized as benign or malignant using a statistical algorithm and the results will be compared with the frozen and permanent section results.


Eligibility criteria:
inclusion criteria: * ductal carcinoma in-situ or invasive carcinoma diagnosed by image directed core biopsy who are planning to undergo breast conserving surgery exclusion criteria: * patients who were diagnosed with excisional biopsy and patients undergoing mastectomy
post operative pain control after pediatric hip surgery

Conditions: Hip Surgery; Post Operative Pain Control

Summary: hip surgery in children is painful and the optimal modality for managing post-operative pain has not been established. this prospective randomized controlled trail compares lumbar plexus catheter (lpc), lumbar epidural catheter (lec) and continuous patient-controlled analgesia (pca) with intravenous morphine.

approximately 1 in 1,000 children born in the us have hip dislocation and 10 in 1,000 have hip subluxation requiring surgical intervention. pain after major hip surgery in children is severe, yet there is no agreement on the most effective method for pain control. post-operative pain modalities including lumbar epidural catheters (lec), lumbar plexus catheters (lpc) and intravenous patient controlled analgesia (iv-pca) have been described. iv-pca has historically been the standard of care in spite of its numerous associated side effects. regional anesthesia modalities have gained popularity because of superior pain control with lower opioid requirements. in this study, the investigators describe the first prospective randomized controlled trial comparing lumbar plexus catheter to alternatives for post-operative pain management in children after major hip surgery. the investigators hypothesized that lpc would be as safe and efficacious as lec and iv-pca with the added advantage of a decreased length of stay. the investigators primary aim was to compare hospital length of stay. secondary aim was to compare pain scores, opioid consumption and opioid-related side effects.

Eligibility criteria:
inclusion criteria: * children undergoing unilateral hip surgery, including pelvic innominate osteotomies, proximal femoral osteotomies, and arthrotomies (for open reduction, loose body removal, labral debridement or labral repair). exclusion criteria: * history of a previous spine surgery, spina bifida, coagulopathy, skin infection, allergies to study medications (i.e. local anesthetics and opioids), patients taking opioids at the time of enrollment and, those having concurrent procedures distal to the hip.
fluorescent approach for refined endoscopic marking with clip localization and identification procedure

Conditions: Colon Cancer

Summary: * title of the study testing a fluorescent surgical marker clip for tumor localization in minimally invasive colorectal surgery * purpose of the study this study aims to determine if a fluorescent surgical marker clip can accurately and safely localize tumor locations in the colon during minimally invasive colorectal surgery. the study will compare the effectiveness of this clip to the current method using a dye called indocyanine green (icg). the main questions the investigators aim to address are: can the clip safely and effectively localize tumor sites compared to icg dye? what side effects or medical issues might arise with the use of the clip? -study design assignment participants will be randomly assigned to one of two groups: the clip group: a fluorescent clip will be placed near the tumor. the dye group: icg dye will be injected near the tumor. procedures participants will undergo a colonoscopy to mark the tumor location before surgery using either the fluorescent clip or icg dye. * follow-up participants will attend follow-up visits after surgery to monitor for any side effects or complications. * eligibility inclusion criteria participants may qualify if: they are 19 years or older. they are scheduled for minimally invasive colorectal surgery for a tumor or suspected tumor. exclusion criteria participants cannot enroll if: they have certain medical conditions, such as blood clotting disorders or allergies to metals or iodine. they are pregnant or breastfeeding. -participant role by participating, individuals will contribute to advancing research aimed at improving methods for tumor localization during surgery, potentially leading to enhanced surgical outcomes in the future. for questions or concerns, participants are encouraged to contact the investigators or the research team.


Eligibility criteria:
inclusion criteria: * aged 19years or more * with colonic neoplasm planning minimally invasive surgery * need localization of lesion before surgery exclusion criteria: * planned total proctocolectomy * contraindication of colonoscopy * on pregnancy or breast-feeding

Keywords: tattooing localization colon cancer
comparative evaluation of bromelain-quercetin gel with chlorhexidine gel as subgingival local drug delivery following scaling and root planing in stage i /ii and grade b periodontitis - randomized control clinical trail

Conditions: Periodontal Pocket

Summary: comparative evaluation of bromelain-quercetin gel with chlorhexidine gel as subgingival local drug delivery following scaling and root planing in stage i /ii and grade b periodontitis - randomized control clinical trail

: periodontitis is a biofilm associated disease that induces an irreversible inflammatory state that leads to the destruction of the supporting structure of the teeth. management of periodontal disease is through thorough removal of biofilm which is pivotal for having better oral health. scaling and root planning (srp) is fundamental treatment for periodontitis. years of documented research have established that chlorhexidine digluconate (chx), gold standard of chemical plaque control agent is safe stable and effective in preventing and controlling plaque formation. bromelain is an extract derived from ananas comosus (popularly known as pineapple), contains proteinases that exhibits anti-inflammatory properties, antibacterial effect against periodontopathogens. bromelain gel has shown to have chemicomechanical method of caries removal. quercetin present in guava have excellent antibacterial actions against periodontal pathogens, aggregatibacter actinomycetemcomitans (aa), porphyromonas gingivalis (pg), prevotella intermedia (pi) and fusobacterium nucleatum (fn). 2% quercetin has shown to be advantageous for subgingival application after scaling and rootplaning. bromelain-quercetin gel has shown adjunctive effect for treatment in covid-19 patients. as there is less literature in this combination, we intend to study its effects. individually bromelain and quercetin have been studied for treatment in oral cavity as gel form. this study will be first of its kind to check the efficacy of 2% bromelain-quercetin gel and to compare its effects with 0.2% chlorhexidine in stage i/ii and grade b periodontits.

Eligibility criteria:
inclusion criteria: * patient with have chronic periodontitis in the age group between 30-50 years. * patients having ≥20 teeth. -.patients with radiographic evidence of bone loss in atleast two teeth. * patients who are systematically healthy. * patients with localized pockets with probing depth of ≤ 5mm. * patients who are cooperative and able to attend the hospital for regular follow-up. exclusion criteria: * patients who have received any surgical or nonsurgical therapy during past 6months * pregnant or lactating females. * use of systemic antibiotics in the past 6 months. * patient who are not willing to give a written informed consent
diagnostic yield and safety of transbronchial lung biopsy using cryoprobes versus conventional forceps. a multicenter study

Conditions: Lung Diseases, Interstitial

Summary: the purpose of this study is to evaluate the diagnostic yield and safety of transbronchial lung biopsies (tblb) with cryoprobe versus conventional forceps in patients with diffuse lung disease.


Eligibility criteria:
inclusion criteria: * \>18 years old * patients with diffuse lung disease candidate to study with transbronchial lung biopsy (tblb). * inform consent signed. exclusion criteria: * fev1 \<40% of reference value. * respiratory insufficiency (po2 \ 45 mmhg). * use of anticoagulant therapy or presence of a coagulation (disorder abnormal platelets counts, international normalized ratio \> 1.5). * bullous emphysema. * pulmonary arterial hypertension. * hypersensitivity to anaesthetic and sedative drugs (lidocaine, midazolam, propofol, remifentanyl). * psychiatric illness. * comorbidities that could increase the risk of the tblb. * pregnancy.

Keywords: cryoprobes transbronchial lung biopsy cryobiopsy
decitabine augments for post allogeneic stem cell transplantation in patients with acute myeloid leukemia and myelodysplastic syndrome

Conditions: Acute Myelocytic Leukemia; Myelodysplastic Syndromes

Summary: allo - hematopoietic stem cell transplantation is currently the only way to cure myelodysplastic syndrome /acute leukemia . the existing experimental results showed that decitabine and 5-azacytidine up-regulated the expression of tumor ags on leukemic blasts in vitro and expanded the numbers of immunomodulatory t regulatory cells in animal models. reasoning that decitabine might selectively augment a graft versus leukemia effect, the investigators used decitabine administration after allogeneic stem cell transplantation to studied the immunologic sequelae.


Eligibility criteria:
inclusion criteria: * histologically confirmed aml in complete or partial remission or mds using who classification undergoing allohsct * high resolution typing hla-matched related or unrelated donor. donors may be mismatched at single antigen at hla-a, -b or -dr locus plus possible single antigen mismatch at hla-c according to institution guidelines. two-antigen mismatch at a single locus is not allowed. * age ≥ 18 * creatinine \< 1.5 times the institutional uln or creatinine clearance (calculated by the cockroft and gault method) ≥ 30 ml/min * bilirubin \< 1.5 times the institutional uln * ast, alt and alkaline phosphatase \< 2.5 times the institutional uln. exclusion criteria: * history of previous allohsct prior to the current allohsct. * persistent aml or mds after allohsct. * positive serology for hiv. * pregnancy or nursing. * other cancers less than or equal to 2 years prior study entry except: basal cell carcinoma of the skin, squamous cell carcinoma of the skin, carcinoma in situ of the cervix, carcinoma in situ of the breast, prostate cancer stage t1a or t1b. * uncontrolled active infections requiring intravenous antibiotics. clinically significant systemic illness (e.g. serious active infections or significant cardiac, pulmonary, hepatic or other organ dysfunction), which, in the judgment of the principal or associate investigator would compromise the patient's ability to tolerate protocol therapy. * known or suspected hypersensitivity to decitabine. * patients may not be receiving any other investigational agents. * general or specific changes in patient's condition that render the patient unacceptable for further treatment in judgment of the investigators.

Keywords: decitabine hematopoietic stem cell transplant wilms' tumor 1 cytolytic t lymphocyte regulatory t cell
anatomical evaluation of the apl tendons in thumb cmc joint and osteoarthritis

Conditions: Thumb Osteoarthritis

Summary: certain ligaments in the human body are designed to be a static stabilizer and others to have a sensory function thus remains an unresolved issue. the presence of mechanoreceptors (sensory corpuscles and free nerve endins) in the human knee and ankle ligaments has implies a sensory role of ligaments in providing afferent information, which in turn regulates intrinsic stiffness in the muscles surrounding the joint, contribuiting to dynamic joint stability. the aim of this study is to use immunohistochemical methods to analyze the general innervation and possible existence of sensory corpuscles in the thumb carpometacarpal (cmc) joint. this study can help to know the contribution of the tendon insertions and ligaments in the dynamic thumb cmc joint stability.

the accessory apl tendons insertions, number of accessory tendons and insertion in trapezium can be a mechanical factor that develop osteophytes and thumb cmc joint osteoarthritis. antibodies against the general nerve marker protein gene product 9.5 (pgp 9.5) and the glial marker s-100 will be use to depict innervation and corpuscular structures. innervation pattern and sensory corpuscules were investigated by other authors in the wrist. s-100 immunoreactivity is in the schwann cells in the central regions of the corpuscle, and pgp 9.5 immunoreactivity marked the axonal structures in the corpuscles. the presence of nerve fascicles and particularly sensory corpuscles in the structures, for exemple capsule and apl insertion near the thumb carpometacarpal joint suggest that these structures in the cmc joint have a propioceptive role in the stability of the joint.

Eligibility criteria:
inclusion criteria: * specimens: adults from 50 to 90 years. exclusion criteria: * specimens: younger than 50 or older than 90 years.

Keywords: thumb osteoarthritis enthesis organ sensory nerve endings