Kornimate/medical-research-clean huggingface dataset:
oxygenation instability and maturation of control of breathing in premature infants

Conditions: Infant,Premature

Summary: premature infants present with significant oxygenation instability in the form of frequent spontaneous episodes of hypoxemia during the first weeks after birth. these infants are also exposed to hyperoxemia. the objective of this study is to determine the extent to which exposure to frequent episodes of hypoxemia and hyperoxemia in extreme premature infants during the early stages of their evolving lung disease is associated with altered maturation and function of their respiratory control system. this study is part of the prematurity-related ventilatory control (pre-vent): role in respiratory outcomes clinical research centers (crc) (u01) cooperative program of the national heart lung and blood institute (nhlbi) of the national institutes of health (nih).

most extreme premature infants present with respiratory failure due to altered lung function compounded by breathing instability due to an immature respiratory control function. premature infants present with significant oxygenation instability in the form of frequent spontaneous episodes of hypoxemia during the first weeks after birth. as a result, these infants receive oxygen supplementation but this is often excessive and these infants are also exposed to hyperoxemia. the extent to which these episodes of hypoxemia or the exposure to hyperoxemia impact on the maturation and function of the control of breathing system in extreme premature infants during the evolving stages of their respiratory disease is unknown. this is a prospective study that will systematically evaluate such association in extreme premature infants. the main objective of this study is to determine the extent to which exposure to frequent episodes of hypoxemia and hyperoxemia in extreme premature infants during the early stages of their evolving lung disease is associated with altered maturation and function of their respiratory control system. this study is part of the prematurity-related ventilatory control (pre-vent): role in respiratory outcomes clinical research centers (crc) (u01) cooperative program of the national heart lung and blood institute (nhlbi) of the national institutes of health (nih).

Eligibility criteria:
inclusion criteria: * premature infants born at 23 0/7- 28 6/7 weeks gestational age * postnatal age up to equivalent to 36 weeks postmenstrual age * requiring supplemental oxygen and/or receiving mechanical ventilation, cpap, nasal ventilation or nasal cannula exclusion criteria: * severe congenital anomalies that may affect life expectancy or pulmonary or neurosensory development * severe cns pathology that may alter respiratory control function
impact of amantadine on traumatic brain injury

Conditions: Trauma, Brain

Summary: the aim of this study is to evaluate whether the addition of amantadine to the management regimen of traumatic brain injury patients would have a favorable effect on recovery and neurological complications in association with prognosis biomarkers interleukin-18 (il-18), neuron-specific enolase (nse) and (neurotensin).

proposal steps 1. approval will be obtained from research ethics committee of faculty of pharmacy, damanhour university. 2. all participants agreed to take part in this clinical study and provide informed consent. 3. patients will be enrolled if they present with clinical signs of trauma, from emergency department at tanta university hospital 4. complete physical, laboratory, radiological assessment will be done for all patients 5. serum samples will be collected for measuring the biomarkers. 6. all enrolled 50 patients will be divided into two groups; group i are patients who will receive amantadine as added on therapy. group ii are patients who will be managed with the standard regimen. 7. all patients will be followed up during 6 weeks period. 8. at the end of 6 weeks, prognosis biomarkers will be withdrawn. 9. statistical tests appropriate to the study design will be conducted to evaluate the significance of the results. 10. measuring outcome: the primary outcome is to compare the effect of adding amantadine on recovery rate and neurological complications in trauma patients. 11. results, conclusion, discussion and recommendations will be given. methodology * 50 patients will be randomized equally to the assigned study groups * prognosis biomarkers (il-18, nse and neurotensin) will be measured using elisa * conventional routine tests (including renal function tests) will be assessed * patients will be evaluated clinically (such as glasgow score...) for recovery rate for neurological complications.

Eligibility criteria:
* inclusion criteria •adult patients will be enrolled if they present with clinical signs of trauma brain injury * exclusion criteria * age lower than 18 * females with positive pregnancy test * known congestive heart failure or ischemic heart disease * any injury disturbs the examination (high cervical cord injury or locked-in syndrome, could be a source of bias) * penetrating head trauma * need for any operation (laparotomy or craniotomy) * severe brain disease (for example cva history or brain tumour) * renal failure with gfr lower than 60 ml/min * patients with unknown identity

Keywords: traumatic brain injury (tbi) interleukin-18 (il-18) neuron specific enolase (nse) neurotensin (nt)
magnetic resonance imaging study of acute pancreatitis

Conditions: Acute Pancreatitis

Summary: to quantitatively analyze the t2\* values of the head, body, and tail of normal pancreas, and observe the value of gre t2\*-weighted mri in the diagnosis of acute pancreatitis and the relationship between the t2\* value and the severity of ap.

1. we design a prospective study about "magetic resonance imaging study of acute pancreatitis". 2. we apply for an account and register our study on the clinicaltrials. 3. in patients with acute pancreatitis, imaging is recommended to confirm the clinical diagnosis, investigate the etiology, and grade the severity of the disease . mr had the excellent resolution of soft tissue，and it has earned an ever more important role in the diagnosis of ap. with the continuous development of mr scanning techniques, the sequence of a multi-echo gradient recalled echo (gre) t2\*-weighted imaging (t2\*wi), which acquires a spin echo signal, t2\* relaxation acquires a gradient echo signal, is a relatively new mri technique. the sequence of a gre t2\*wi requires high uniformity of the magnetic field, plus it can provide the t2\* value, which can indirectly reflect changes in tissue biochemical components, thus it can be used for the early diagnosis quantitative diagnosis of some diseases . 4. this calculation process for t2\* value is completed using post-processing software on the workstation(advantage workstation 4.4; ge halthcare) directly after scanning. 5. ap is a process of inflammation diffusion, in which cell edema will lead to hydrogen proton increase. in the inflammatory exudation process, t2\* value will change. so we conduct our research. in this study, we will observe pancreas in the normal pancreas and ap, and discuss the relationship between t2\* value and that of ap graded by the mr severity index (mrsi) and acute physiology and chronic healthy evaluation ii (apache ii) scores. 6. however, until now, there is no research on the sequence applied in the patients with ap.

Eligibility criteria:
inclusion criteria: * acute onset of abdominal pain; * pancreatitis at first onset; * three-fold elevated amylase or lipase, excluding other causes of elevated enzymes; and * abdominal mr examination. exclusion criteria: * inability to cooperate when mr imaging was performed; * a history of chronic pancreatitis; * ap due to pancreatic carcinoma; * hypoproteinemia; * with hypoproteinemia and other peritoneal/ retroperitoneal infection diseases ; * with iron deposition disorder (e.g. diabetes or blood system diseases).

Keywords: pancreatitis mri apacheⅱ t2* t2 star
influence of the number of layers of a one bottle adhesive on the longevity of composite restorations in primary molars

Conditions: Dental Caries; Secondary Dental Caries

Summary: the aim of this study is to determinate the influence of an alternative adhesive application protocol (i.e. consecutive application of an extra adhesive layer)on restoration longevity in primary molars.

adhesive systems based on total etch technique remains the most popular products among dental practitioners. these systems are based on the use of an acid conditioner to remove the smear layer and demineralize the enamel and dentin. after the removal of the conditioner by rinsing, a mixture containing the primer and adhesive - i.e. one bottle adhesives - is applicated over the demineralized tissues. the polymerization of the adhesive monomers into microporosities created by acid conditioning forms the structure knowing as hybrid layer or resin-dentin interdifusion zone. a common problem related to total etch technique is the incomplete infiltration of adhesive monomers through demineralized dentin, resulting in the presence of a zone of unprotected collagen fibrils beneath the hybrid layer that is prone to enzymatic degradation. according to some laboratory studies, consecutive application of multiple adhesive coats results in quantitative and qualitative improvements in dental adhesion. in addition to increasing the values of bond strength to dentin, consecutive application of multiple adhesive layers enhances the infiltration of adehesive monomers through demineralized dentin, resulting in a more homogenous hybrid layer.

Eligibility criteria:
inclusion criteria: * presence of two or more pairs of caries lesions in occlusal or occluso-approximal surfaces of primary molars exclusion criteria: * systemic diseases in which dental treatment is a risk to patient's life * bruxism * orthodontic appliance * absence of occlusal contact in eligible teeth * signs and symptoms of pulp infflamation or necrosis

Keywords: dentin bonding agents composite restorations dental restoration failure
emotion regulation skills training for individuals with ms and their support partners

Conditions: Multiple Sclerosis

Summary: this pilot randomized controlled trial investigates a novel, group-based emotion regulation skills training intervention for reducing anxious and depressive symptomatology and improving emotion regulation and problem solving in individuals with ms and the individual's support partners. participants will be randomized (1:1) to the intervention ("partnered emotion regulation skills intervention and supportive teaching \[persist\]") or to the active control (facilitated peer support).


Eligibility criteria:
inclusion criteria: * at least 18 years old * able to speak/read in english * able to commit to attending at least 9 of the 12 weekly group sessions * individuals with ms must be relapse/exacerbation-free for at least 1 month * support partners must score at least 8 on the hads-d or hads-a * individuals with ms must score a least 11 on the hads-d or hads-a exclusion criteria: * under 18 years old * unable to speak/read in english * unable to commit to attending at least 9 of the 12 weekly group sessions * ms relapse within 1 month
evaluation of skin affix in the emergency room

Conditions: Wounds

Summary: effectiveness of a surgical adhesive on wounds found in emergency medicine.

subjects were approached for recruitment in the ed when discussing closure options by the physician. only subjects deemed appropriate for skin glue closures by their treating physician were approached.subjects were followed at 48 hours post-procedure, 5-10 days, and at 14 days following the ed visit.

Eligibility criteria:
inclusion criteria: * greater than 5 years of age * requires the use of a surgical skin adhesive * informed consent signed exclusion criteria: * sensitivity to topical adhesive products or formaldehyde * hx keloid formation, hypotension, diabetes, blood clotting disorders * wound infections * mucosal surfaces or skin exposed to body fluids

Keywords: skinaffix
salt sensitivity, cardiovascular and metabolic disease

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension; Angina Pectoris; Cerebrovascular Accident; Myocardial Infarction; Diabetes Mellitus; Heart Failure, Congestive; Heart Failure

Summary: to identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.

design narrative: approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. this helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. in addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.

Eligibility criteria:
no eligibility criteria
yoga to reduce fatigue in hospitalized children receiving intensive chemotherapy

Conditions: Fatigue

Summary: cancer-related fatigue (crf) is a major problem in children, adolescents and adults receiving treatment for cancer, and intensively treated patients may be at higher risk. while exercise is an effective intervention for crf, patients receiving the most intensive chemotherapy may frequently be too ill to participate in a standardized exercise program. a unique intervention that combines exercise and relaxation is yoga. this pilot study will evaluate the feasibility of three times weekly yoga sessions administered by a trained yoga instructor for a three week duration and will enroll between 10 and 20 children. if feasible, the intervention will be tested in a randomized controlled trial.


Eligibility criteria:
inclusion criteria: * diagnosed with any acute myeloid leukemia (aml), relapsed acute lymphoblastic leukemia, stage 3 or 4 burkitt's lymphoma/leukemia or about to receive autologous or allogeneic haematopoietic stem cell transplantation (hsct) * expected to be an inpatient for at least three weeks after initiation of chemotherapy or conditioning * ages 7 to 18 years of age at enrollment exclusion criteria: * features present to an extent that would preclude compliance with yoga (as assessed by the attending physician): a) motor disability, b) cognitive disability, c) cardiopulmonary symptoms, or d) known compression fracture resulting in disability * parent or patient cannot understand english

Keywords: fatigue quality of life chemotherapy haematopoietic stem cell transplantation children pilot yoga
acupuncture for women's health conditions

Conditions: Ovarian Neoplasms; Endometriosis; Pelvic Pain; Uterine Neoplasms

Summary: the purpose of this study is to evaluate the safety and effectiveness of acupuncture in treating women's health conditions.

this trial comprises three studies. in the first two studies, women will be randomly assigned to receive either real or sham acupuncture therapy. study 1 will include women with various forms of cancer. white blood cell counts will be used to assess the effects of acupuncture on participants' immune responses. study 2 will include women with unspecified pelvic pain and endometriosis; a self-report pain scale will be used to assess the effects of acupuncture on participants' symptoms. study 3 will evaluate the validity and reliability of diagnoses made by chinese medicine practitioners. in this study, a group of chinese medicine practitioners will diagnose the same group of patients; consistency of the diagnoses will be evaluated.

Eligibility criteria:
inclusion criteria for study 1: * newly diagnosed ovarian cancer; primary peritoneal cancer; papillary serous cancer of the endometrium; or mixed mesodermal tumor of the uterus, ovary, or fallopian tube * currently undergoing chemotherapy * meet certain laboratory test requirements inclusion criteria for study 2: currently closed to recruitment * diagnosed with endometriosis or unspecified pelvic pain exclusion criteria for studies 1 and 2: * use of white blood cell boosters * prior radiotherapy with the exception of whole-breast irradiation for breast cancer * prior myelotoxic chemotherapy * history of symptomatic cardiac or psychiatric disorder * use of a pacemaker * use of herbs or herbal supplements * prior use of acupuncture * enrollment in other research studies

Keywords: acupuncture medicine, chinese traditional
investigating a von willebrand factor (vwf) functional screening assay for assigning the phenotypic variants of von willebrand disease (vwd)

Conditions: Von Willebrands Disease

Summary: the purpose of this study is to improve the investigators ability to diagnose von willebrand disease (vwd), a common inherited bleeding disorder. this study will look at a new screening blood test used to determine if a person has vwd. this new screening blood test can determine a diagnosis more rapidly than current blood tests. also this test could be available at local hospital labs rather than require samples to be sent to bigger more specialized labs.

this investigation will be a prospective, multicenter trial to validate the clinical utility of a novel screening assay as a diagnostic screening assay for vwd variants: type 1c, 2a, 2b, 2m and 2n. once the subject is enrolled into the study, a minimum of 0.5ml of citrated plasma will be collected and analyzed at the bleeding and clotting disorders institute laboratory in peoria illinois. results will be collected: phenotype function profiles will be determined, statistically analyzed and compared to the qualitative data from blood center of wisconsin. data is expected to correlate as previously shown in prior studies and will confirm the utility of this assay.

Eligibility criteria:
inclusion criteria: * new subjects undergoing evaluation for the diagnosis of vwd determined to have a vwf:ag or vwf: rco \< 50 iu/dl and or a vwf:rco/vwf:ag of \<0.7. also subjects will be included if type 2 n vwd is clinically suspected exclusion criteria: * those subjects whose lab results do not meet the inclusion criteria

Keywords: bleeding disorder, inherited von willebrands disease hematologic test vwf vwd
gluconeogenesis in very low birth weight infants who are receiving nutrition by intravenous infusion

Conditions: Infant, Low Birth Weight; Hyperglycemia

Summary: rationale: very low birth weight infants have problems maintaining normal blood sugar levels. gluconeogenesis is the production of sugar from amino acids and fats. the best combination of amino acids, fat, and sugar to help very low birth weigh infants maintain normal blood sugar levels is not yet known. purpose: clinical trial to study how very low birth weight infants break down amino acids, fat, and sugar given by intravenous infusion, and the effect of different combinations of nutrients on the infants' ability to maintain normal blood sugar levels.

protocol outline: patients are assigned to one of 6 study groups. patients receive infusions of stable isotope tracers: \[15n\]urea iv beginning at -12 hours and continuing over 22 hours to measure protein oxidation; \[u-13c\]glucose iv beginning at zero hour and continuing over 10 hours to measure glucose appearance rate and gluconeogenesis; \[2-13c\]glycerol iv over 10 hours to measure lipolysis; and \[1-c\]leucine iv over 10 hours to measure proteolysis. blood samples are obtained before the start of the urea tracer infusion; before the start of the glucose, glycerol, and leucine tracer infusions; and at study hours 4, 4.5, 5, 9, 9.5, and 10. blood glucose is measured hourly, and patients receive glucose iv if blood glucose falls below 40 mg/dl. group i: patients are randomized to one of two study arms. arm i: patients receive standard total parenteral nutrition (tpn), except the \[u-13c\]glucose is substituted for a portion of the glucose. arm ii: the infusions of lipids (intralipid) and amino acids (trophamine) are discontinued at study hour zero. the infusion rate of natural glucose will be reduced during the first hour, and thereafter discontinued. group ii: patients are randomized to receive either trophamine or intralipid iv over the last 5 hours of the study. group iii: patients are randomized to receive one of two different doses of glycerol iv over the last 5 hours of the study. group iv: patients are randomized to receive either glutamine or alanine iv over the last 5 hours of the study. group v: patients receive glucagon iv for 24 hours prior to study. patients are then randomized to receive glucagon iv with either iv glucose alone or with intralipid and trophamine iv. group vi: patients who are hyperglycemic receive tpn and \[u-13c\]glucose as in group i, arm i, over 14 hours, and regular insulin iv at 10 hours, followed by an iv infusion of carbohydrate. blood samples obtained between hours 4 and 5 are omitted, and are drawn instead between hours 13 and 14.

Eligibility criteria:
* clinically stable, very low birth weight infants (750-1,500 grams) * normal blood glucose values or blood glucose greater than 175 mg/dl * no prior insulin * no sepsis oxygen supply less than 30% normal acid base status * no malformation * no discernible diseases

Keywords: endocrine disorders hyperglycemia low birth weight neonatal disorders rare disease
targeted letters to reduce avoidable emergency department attendances

Conditions: Avoidable Emergency Department Attendances

Summary: the study aims to test whether it is possible to reduce pressure on emergency departments by sending a personal feedback letter to people who have recently attended an emergency department and whose health issues could likely have been dealt with elsewhere. these attendances clearly have many causes. however, it is likely that some attendances are due to behavioural factors - in other words, the various ways in which users interact with services. this study focuses on one particular behavioural factor: lack of feedback to users making avoidable visits. the study will take place in collaboration with an nhs hospital trust. each week during the trial, the hospital trust will identify those emergency department attendances in the last seven days which, according to clinical judgement, could have been dealt with elsewhere. patients will then be randomly selected to receive a letter containing information on alternative healthcare options for non-emergency health concerns. patient records will be analysed to determine whether the patients who received the letter are less likely to make an avoidable repeat visit to the emergency department in the future, compared with patients who received no letter.


Eligibility criteria:
inclusion criteria: * adults who attended a participating emergency department during the trial period and whose attendance was codes as 'no investigation no significant treatment' exclusion criteria: * children under the age of 18 * all departments and hospitals other than participating emergency departments.