Kornimate/medical-research-clean huggingface dataset:
operative versus non-operative management of rotator cuff tear

Conditions: Rotator Cuff Tear

Summary: this study aims at determining the effectiveness and cost-effectiveness of surgical management of full-thickness rotator cuff tears compared to conservative treatment. the research setting is prospective, randomised, and controlled. the aim of the study is to search out evidence based data of indications for rotator cuff repair. the investigators also aim at offering patients the most efficient and effective treatment and reduce the number of operations that do not have sufficient effectiveness. the data obtained will facilitate developing guidelines for referrals to a specialist when rotator cuff tear is suspected. the investigators hypothesize that there are subgroups of patients suffering from rotator cuff tears that benefit from surgery whereas other subgroups are best treated conservatively.

subgroup analyses: * age * sex * duration of symptoms * presence of trauma before symptoms * size of tear * degenerative findings * other findings in mri or arthroscopy * type of operation * co-morbidities * occupation * pain (vas) * objective shoulder function * activities of daily living

Eligibility criteria:
inclusion criteria: * age over 35 years old * duration of symptoms at least three months despite of non-operative treatment * the patient accepts both treatment options (operative and conservative) * a full-thickness rotator cuff tear in mri arthrography exclusion criteria: * previous shoulder operations * too high risk for operation * any disease or social problem reducing the ability to co-operate * rheumatoid arthritis * severe arthrosis of the glenohumeral or acromioclavicular joint * irreparable rotator cuff tear (including rotator cuff tear arthropathy) * progressive malign disease * adhesive capsulitis * high-energy trauma before symptoms * cervical syndrome * shoulder instability

Keywords: rotator cuff arthroscopic surgery open surgery physiotherapy physical therapy effectiveness rct cost-effectiveness
open versus video-assisted minimal-invasive parathyroid surgery

Conditions: Primary Hyperparathyroidism

Summary: the aim of the present study was to compare open minimal-invasive parathyroid surgery with video-assisted parathyroidectomy in primary hyperparathyroidism (phpt) patients with a positive sestamibi scan in a multicentre randomized trial in order to evaluate if videoassisted surgery gave less postoperative pain and if there was a difference in operating time.

the present study is designed to compare open minimal-invasive parathyroid surgery with video-assisted parathyroidectomy in phpt patients with a positive sestamibi scan in a multicentre prospective randomized trial. in patients randomized to open surgery, a 15 mm transverse skin incision is made close to the site of the parathyroid adenoma indicated by sestamibi scintigraphy. in case of an enlarged upper parathyroid or dorsally located lower parathyroid, the incision is made anterior to the sternocleidomastoid muscle (scm) whereas for anterior located lower parathyroids a central incision is chosen. in patients randomized to a video-assisted approach, the surgeon has the option to choose either the lateral- (vapla) or medial (mivap) techniques, both initiated with a 15 mm transverse skin incision. postoperatively the patients receive a questionnaire for selfdocumentation.variables recorded include postoperative pain, hypocalcaemic symptoms, breathing problems, cervical discomforts of pressure/globus and voice disturbances. a visual analogue scale (vas) is used when appropriate. the intake of oral analgesics and calcium medication is also recorded. the questionnaire is used daily for the first four postoperative days, and thereafter weekly for four weeks. follow-up is done at 1 and 6 month after surgery, with measurement of plasma calcium and pth. continued needs of calcium or vitamin d medication, length of scar, and symptoms or signs of complications are recorded. at the six-month follow-up, patients document their opinion of the cosmetic results and the remaining neck discomfort using a vas. primary outcome measures are postoperative pain and operation time. secondary outcome measures are complications, persistent or recurrent disease, conversion rates and cosmetic results.

Eligibility criteria:
inclusion criteria: * patients with biochemically verified primary hyperparathyroidism and with an unequivocal localisation on sestamibi scintigraphy of a solitary parathyroid adenoma exclusion criteria: * negative or equivocal preoperative localization study, familiar hpt, previous neck surgery or neck irradiation, concomitant need of thyroid surgery, pregnancy, suspected ectopic parathyroid localization, or inability to understand information, instructions and/or comply with scheduled follow-up.

Keywords: hyperparathyroidism surgery minimal invasive videoassited
trilaciclib prevents myelosuppression with chemoradiotherapy

Conditions: Myelosuppression

Summary: to evaluate the protective effect of trilaciclib on myelosuppression in patients with limited-stage small cell lung cancer associated with concurrent chemoradiotherapy and discuss the effect of gut microbiota changes on myelosuppression

the occurrence of myelosuppression following chemotherapy, including severe neutropenia and hematological toxicity (grade 3/4), as well as its association with dynamic changes in the gut microbiota, was investigated in conjunction with prophylactic administration of the cdk4/6 inhibitor trilaciclib prior to the initiation of chemotherapy during radiotherapy for limited stage small cell lung cancer.

Eligibility criteria:
inclusion criteria: 1. the histopathology is limited-stage small cell lung cancer. 2. ecog score 0-2. 3. good organ function (no blood transfusions, no hematopoietic stimulating factors, no transfusions of albumin or blood products within 14 days prior to the examination). 4. it is suitable for patients treated with trilaciclib combined with etoposide plus cisplatin or carboplatin. 5. understand and can sign informed consent exclusion criteria: 1. brain metastases with clinical symptoms require local radiotherapy or hormone therapy. 2. active infections require systemic treatment. 3. subjects with active, known or suspected autoimmune disease or history of autoimmune disease. 4. combined with other tumors. 5. the current or previous presence of a clinically significant and medically unstable condition, which in the investigator's professional judgment may compromise subject safety, interfere with study evaluation or endpoint assessment, or otherwise impact the reliability of study results.
virtual reality versus proprioceptive neuromuscular facilitation on postmastectomy lymphedema

Conditions: Postmastectomy Lymphedema

Summary: this study aimed to compare the therapeutic efficacy of vr and pnf on lymphedema and function in unilateral post-mastectomy lymphedema (upml) patients. the patients were subdivided into two equal groups, 15 in each. fifteen patients performed virtual reality-based exercises plus complete decongestive therapy, while the other fifteen patients performed proprioceptive neuromuscular facilitation plus complete decongestive therapy. the volume difference between normal and affected limbs was calculated before and after eight sessions of treatment for both groups by using the circumferential method. and the upper limb function was assessed before and after eight sessions of treatment for both groups by using the arabic version of the quick dash scale.


Eligibility criteria:
inclusion criteria: * patients will suffer from unilateral post-mastectomy lymphedema. * stage i and stage ii lymphedema as defined by the classification of the international society of lymphology (the international society of lymphology, 2003). * patients had no physical therapy before the current treatment or the last time to receive sessions was at least three months ago. exclusion criteria: * excluded patients were having musculoskeletal or neurological disorders that would impair performance during training and tests. * visual disorders that could affect imitation of video game-based exercise. * uncontrolled cardiovascular or pulmonary diseases. * psychiatric illness, severe behavior, and cognitive disorders.
evaluation of a new catheter material for intermittent catheterization

Conditions: Catheterization (Clean, Intermittent Urinary Catheterization)

Summary: the hypothesis to be investigated is if the tolerability of intermittent catheterization with polyolefin based elastomer (pobe) 2.0 and polyvinyl chloride (pvc) is clinically equal - i.e. clinically non-inferior when using pobe 2.0 compared to pvc. secondary objectives are to evaluate the safety and the subject's perception associated with the use of the catheters, assessed by the recording of adverse events and the ease of handling by means of a subjective assessment scale.


Eligibility criteria:
inclusion criteria: * provision of informed consent * males, aged 18 years and over * maintained urethra sensibility * practice intermittent self-catheterization at least 2 times daily * using catheters in the length of 40 cm and size charrière (ch) 12 or ch 14 * experienced practitioners of intermittent self-catheterization defined as a minimum of three months on therapy * experience of using lofric catheter within the last 12 months prior to study entry * adults able to read, write and understand information given to them regarding the study exclusion criteria: * ongoing, symptomatic urinary tract infection (uti) at enrolment as judged by investigator * known urethral stricture at enrolment as judged by investigator * involvement in the planning and/or conduct of the study (applies to both astra tech staff or staff at the study site) * previous enrolment or randomisation of treatment in the present study
4-aminopyridine treatment for nerve injury

Conditions: Nerve Injury; Prostate Cancer

Summary: to evaluate the role of 4-aminopyridine (4-ap) on the course of recovery after peripheral nerve traction and/or crush injury. this study aims to test the hypothesis that 4-aminopyridine speeds the often slow and unpredictable recovery after peripheral nerve traction and/or crush injuries.

to evaluate the role of 4-ap on the recovery of nerve function we will be giving patients with prostate cancer who are undergoing robot assisted radical prostatectomy (rp) either 4-ap or placebo in the perioperative period. this population of patients was selected as nerve crush injury during rp is thought to contribute to erectile dysfunction and urinary continence post operatively.

Eligibility criteria:
inclusion criteria * male patients with organ-confined, non-metastatic prostate cancer (stages ct1c-t2c), planning to undergo robotic-assisted laparoscopic bilateral nerve sparing radical prostatectomy (nsrp) * prostate-specific antigen (psa) levels less than 15 ng/ml (within the last 12 months), with biopsy-proven prostate cancer, for whom postoperative adjuvant therapy (e.g. radiation or androgen deprivation therapy) is not expected to be needed * ages 45-75 * an abridged international index of erectile function-erectile function (iief-5) score of greater than or equal to 17 at time of screening * has experienced at least 6 months of regular sexual activity and sexual activity during the 12 weeks prior to prostate biopsy or surgery * willingness to abstain from treatments for erectile dysfunction until 3 months after surgery * willingness to participate and able to provide informed consent exclusion criteria * planned adjuvant therapy after nsrp based on specimen pathology and stage of prostate cancer (stage t3 or greater), positive lymph nodes or positive surgical margins * neo-adjuvant therapy prior to nsrp * history of recurrent prostate cancer * history of seizures, multiple sclerosis, stroke or any other diagnosed neurological disorder * history of non-organ confined or metastatic prostate cancer (clinical stages t3 or greater) * history of known hypersensitivity to 4ap * patients with history of penile surgery other than circumcision or endoscopic urethral stricture surgery * renal impairment based on calculated gfr (gfr\<60 ml/min) * use of any other aminopyridine medications for any other indication

Keywords: prostatectomy erectile dysfunction prostate cancer nerve injury incontinence
investigation of neurophysiological markers, possibly specific of two subforms of psychotic disorders

Conditions: Schizophrenia

Summary: the current diagnostic criteria for schizophrenia and other psychotic disorders are relatively broad and lack precision. therefore, distinct diseases may be grouped together under the same diagnostic category, although these diseases may differ according to their clinical expression, prognosis and perhaps their physiopathological causes. we think that identifying subforms of psychotic disorders that are more homogeneous will better enable to understand their respective physiopathological causes and find personalized treatments. this study will compare two subforms of psychotic disorders that have been clinically distinguished in the 1970s. these phenotypes have however not been validated yet using scientific investigations. using clinical assessments, cognitive evaluations and neurophysiological measures (fmri) investigating the domains of affect and psychomotoricity , we expect that these two subforms will differ on their clinical, cognitive and neurophysiological characteristics, namely: hebephrenia will be associated with deficits on the affect markers , and respect psychomotoricity (catatonia scales, tests assessing movement planification) whereas the opposite pattern will be observed for periodic catatonia.


Eligibility criteria:
inclusion criteria: * for both patients and controls * male or female willing to participate and who have signed up the legal document * under the protection of health insurance for patients only * schizophrenia or schizo-affective disorder according to the dsm-5 criteria * periodic catatonia or hebephrenia accordin to wkl classification * clinically stable for at least 2 months * in or out patients for controls only * no psychiatric history exclusion criteria: * for both patients and controls * current severe or unstable somatic illness * neurological history (epilepsia, brain injury, brain surgery...) * current substance use disorder (dsm-5) * current major depressive disorder (dsm-5) * mental retardation (iq \< 70) * pregnancy, breast feeding * current legal control * contra-indication for fmri for controls only psychotropic intake during the last 3 weeks
investigation of factors causing knee hyperextension during walking in chronic stroke patients

Conditions: Stroke

Summary: in this study, it is aimed to examine the factors that cause knee hyperextension in chronic stroke patients. although the presence of weakness or spasticity in the quadriceps muscle, weakness or spasticity in the plantar flexors, and weakness of the dorsiflexors, hamstrings and gastrocnemius muscle are shown in the literature as the cause of hyperextension of the affected knee in hemiplegic patients, there is a comprehensive study that shows the effect of both muscle strength and spasticity in the lower extremity muscles. there are no studies. the hypotheses of the study are: hypothesis 1: h0: there is no relationship between knee hyperextension in the stance phase of gait and lower extremity muscle strength in stroke patients. h1: there is a relationship between knee hyperextension in the stance phase of gait and lower extremity muscle strength in stroke patients. hypothesis 2; h0: there is no relationship between knee hyperextension in the stance phase of gait and lower extremity spasticity in stroke patients. h1: there is a relationship between knee hyperextension in the stance phase of gait and lower extremity spasticity in stroke patients. hypothesis 3; h0: there is no relationship between knee hyperextension and electromyographic muscle activations in chronic stroke patients. h1: there is a relationship between knee hyperextension and electromyographic muscle activations in chronic stroke patients.


Eligibility criteria:
inclusion criteria: * being between the ages of 40-65 * at least 6 months have passed since the stroke * ambulation with or without a walking aid (walker, cane, or tripod) * being between 0-3 points according to the modified rankin score * getting a score of 24 or higher on the mini mental test * presence of hyperextension in the stance phase of gait * volunteering to participate in the study exclusion criteria: * having a history of more than one stroke * known presence of dementia * having a known orthopedic, psychiatric or other neurological disease * having a situation that prevents communication * having a history of surgery involving lower extremities and gait

Keywords: gait analysis stroke knee hyperextension electromyography
effect of segmental muscle vibration on upper limb function in post stroke patients

Conditions: Stroke

Summary: the aim of this study is to observe and to compare effects of segmental vibration on flexors versus extensor muscle groups on upper limb function in post-stroke patients. this study will be helpful in finding out that either low frequency segmental vibration on flexors muscle group is better in improving upper limb function or low frequency segmental vibration on extensor muscle group is more beneficent in improving upper limb function.

stroke is the leading cause of long-term disability and is often associated with persistent involvement of upper limbs.several disturbances are the manifestation of ul impairments after stroke (i.e., muscle weakness, changes in muscle tone, joint disturbances, impaired motor control) . muscular weakness and spasticity are most commonly observed in post stroke patients. there are many strategies are developed to improve functional status and to reduce spasticity pattern in post stroke patients. among the different approaches to improve motor functions in post stroke patients, vibration therapy gives strong stimulatory effects in post paretic limb. segmental muscle vibration (smv) is a fairly new technique that has been used to improve motor function and inhibit spasticity in the hemiplegic upper extremity of patients following a stroke. in smv, a vibratory stimulus is applied to a specific muscle tendon using a mechanical device unit.the aim of this study is to observe and to compare effects of segmental vibration on flexors versus extensor muscle groups on upper limb function in post-stroke patients. this study will be helpful in finding out that either low frequency segmental vibration on flexors muscle group is better in improving upper limb function or low frequency segmental vibration on extensor muscle group is more beneficent in improving upper limb function.

Eligibility criteria:
inclusion criteria: * both genders * age: between 50-65 years. * spasticity 1-3 on mas * 3-6 months post stroke patients exclusion criteria: * cardiovascular event (myocardial ischemia or infarction) occurring within 12 months, * use of any antispastic drug * pain from vibration * inflammatory osteoarticular diseases

Keywords: segmental muscle vibration,spasticity,upper limb function
duplex us in pelvic congestion syndrome in females (pcs)

Conditions: Pelvic Pain Syndrome

Summary: to investigate the feasibility of duplex us in diagnosis of pelvic congestion syndrome

* in the past, a diagnosis of chronic pelvic pain left many women frustrated with few treatment options and a lack of available resources. their physicians were likewise perplexed, despite the endless acquisition of negative laboratory and imaging data as well as inconclusive consultations obtained. in the last 10 years, improved scientiﬁc understanding and increased physician awareness have lessened the confusion surrounding this condition and its distinct association with pelvic congestion syndrome (pcs). furthermore, reﬁnements of medical and minimally invasive surgical solutions give affected patients more therapeutic choices today. * since anatomical venous variations in the pelvis are common, it is important to know the anatomy of these vessels for treatment planning. imaging is critical in the evaluation of pelvic varices, both to differentiate them from other condition and also because pelvic varices may be secondary to serious underlying pathology, such as inferior vena caval obstruction, portal hypertension, increased pelvic blood flow, and vascular malformations. sonographic findings of pelvic congestion syndrome were dilated left ovarian vein with reversed caudal flow, presence of varicocele, dilated arcuate veins crossing the uterine myometrium, polycystic changes of the ovary, and variable duplex waveform during the valsalva's maneuver. combined transabdominal and transvaginal sonography are potentially useful as a noninvasive screening \& grading tool for determining which patients with chronic pelvic pain may benefit from selective ovarian venography and transcatheter embolization

Eligibility criteria:
inclusion criteria: * all patients with signs and symptoms of pcs exclusion criteria: * no

Keywords: pcs
home telemonitoring in patients after myocardial infarction

Conditions: Myocardial Infarction; Heart Attack

Summary: this study is being done to determine if taking an electrocardiogram (ecg) by a portable device (smartheart) followed by a phone call will improve patient outcomes by early recognition of abnormalities and decrease emergency room visits and hospital readmissions compared to standard therapy alone.


Eligibility criteria:
inclusion criteria: * acute myocardial infarction, both stemi and non-stemi. * able to use the home ecg telemonitoring. * must have smartphone device with home wi-fi/mobile internet which allows for 24/7 ability to transmit ecg. * caring family member who will be able to help/perform the ecg in case the patient won't be able to do it. exclusion criteria: * no ability to use the device at home/unable to comply with the device instructions * no smartphone device or home wi-fi/mobile internet which prevent 24/7 ability to transmit ecg * cannot download the smartheart app * no support in home environment * out of hospital cardiac arrest: secondary to a non-shockable rhythm, unrelated to an acute coronary syndrome, or with any level of neurologic damage. * resident of nursing home or acute care facility * uninterpretable ecg at discharge - left bundle branch block (lbbb), pacemaker or implantable cardioverter defibrillator (icd) with pacing dependence. * patients who are planned for staged pci after the index hospitalization