Kornimate/medical-research-clean huggingface dataset:
development and application-smart football for movement evaluation and training in the special education population

Conditions: Intellectual Disability

Summary: children with disabilities are frequently ignored by the general population, hence the development of movement evaluation and training devices for use in special education settings are relatively overlooked. usually the performance of these children is not stable and contains variations. hence in order to get a complete picture of their sport performance, simply measuring movement time and distance is definitely not representative. with the rising attention from government regarding fitness and social participation of the disabled in recent years, developing a special-designed individual evaluation \& training plan is of great importance. to achieve this goal, a device which is able to record the complete process of movement, and contains algorithm that can pick up the movement characteristics of children with disabilities is needed. the purpose of this study is to design and develop a smart soccer ball system for use in children with intellectual disabilities(id), and to compare the performance between children with id and the typically developed.


Eligibility criteria:
inclusion criteria: 1. intellectual disabilities (id) group: * children with mild to moderate intellectual disabilities. * able to walk independently * can follow simple commands 2. typical developed children: * age-matched td children exclusion criteria: 1. fracture or receive orthopedic surgery within six months. 2. participate in regular soccer training.

Keywords: assistive device the disabled special education movement analysis system development
a study for adult patients with fibromyalgia

Conditions: Fibromyalgia, Primary; Fibromyalgia, Secondary

Summary: the main purpose of this study is to determine if 30 milligrams (mg) of duloxetine is effective in the treatment of fibromyalgia compared to placebo.


Eligibility criteria:
inclusion criteria: * meet study criteria for fibromyalgia diagnosis. exclusion criteria: * have previously or are currently taking duloxetine. * have been diagnosed with certain psychoses, bipolar or schizoaffective disorder * have pain symptoms that are difficult to differentiate from fibromyalgia. * have seizure disorder, uncontrolled narrow angle glaucoma, or acute liver injury (such as hepatitis) or severe cirrhosis. * have had any primary axis 1 diagnosis other than major depressive disorder or generalized anxiety disorder within the past year. * are pregnant or breast-feeding * have a current or previous diagnosis of rheumatoid, infectious or inflammatory arthritis or an autoimmune disease * have a regional pain syndrome, failed back syndrome or chronic localized pan related to any past surgery * have a serious unstable medical illness * have a history of substance abuse or dependence within the past year
randomized study of elective regional lymph node irradiation in n1 breast cancer

Conditions: Breast Neoplasm

Summary: this study evaluates the impact of elective regional lymph node irradiation on n1 breast cancer patients receiving post-lumpectomy radiotherapy and anthracycline plus taxane (at)-based chemotherapy. we randomly assign patients having one to three metastatic lymph nodes (pn1) after breast-conserving surgery (bcs) and at-based chemotherapy to undergo either whole-breast and regional nodal irradiation (wb+rni group) or whole-breast irradiation alone (wbi group).

objective: * compare the effect of post-bcs wbi vs. wb+rni on disease-free survival in pn1 breast cancer patients who received at-based chemotherapy. * evaluate the impact of wbi or wb+rni according to molecular subtype of tumor. * compare the treatment-related toxicities between the wbi and wb+rni. * compare the patient's quality of life between the wbi and wb+rni. outline: this is a a randomized, multi-center, phase iii study. patients are stratified according to molecular subtype of tumor (luminal a vs luminal vs luminal her2 vs her2-enriched vs basal-like), axillary lymph node management (sentinel lymph node biopsy \[sln\] only vs axillary lymph node dissection+/- sln) and participating institutions. patients are randomized to one of two treatment arms. * arm i: patients receive wb+rni. * arm ii: patients receive wbi alone. arm circumference and quality of life (eortc qlq-c30 \& eortc qlq-br23) are assessed within 2 weeks prior to randomization, during the last week of radiotherapy, at 3 months after completion of radiotherapy, and then annually thereafter for five years. patients are followed at 3 months after completion of radiotherapy and annually thereafter for seven years.

Eligibility criteria:
inclusion criteria: * histologically proven invasive carcinoma of the breast. * one to three positive axillary lymph nodes (pn1) proven in pathologic specimen. * prior breast-conserving surgery and post-operative adjuvant chemotherapy including taxane. * administering adjuvant hormonal therapy in cases with hormone receptor-positive tumor. * administering anti-her2 therapy in cases with her2-positive tumor. exclusion criteria: * metastases in supraclavicular or internal mammary lymph nodes. * metastases in distant organs. * neoadjuvant chemotherapy or hormone therapy before surgery. * not receiving adjuvant anthracycline and taxane. * bilateral breast cancer * previous history of radiotherapy of the ipsilateral breast or supraclavicular lymph nodes. * prior history of other types of cancer, except thyroid cancer, carcinoma in situ of the cervix, or skin cancer.

Keywords: adjuvant radiotherapy lymphatic irradiation taxane anthracycline prospective study
effects of egcg (epigallocatechin gallate) in huntington's disease (eton-study)

Conditions: Huntington Disease

Summary: huntington's disease (hd) is an inherited autosomal dominant, progressive neurodegenerative disease. clinically, hd is characterized by a triad of movement disorders, cognitive impairments and psychiatric disturbances. these symptoms represent a tremendous burden for patients and caregivers. hd is a fatal disorder with neither cure, nor evidence-based standard therapy available. the green tea polyphenon (2)-epigallocatechin-3-gallate (egcg) was shown to have beneficial effects in cell and animal models of hd. the aim of this study is to evaluate the efficacy and tolerability of egcg in hd. the investigators hypothesize that sunphenon egcg administered at a maximal daily dose of 1200 mg compared to placebo during a period of 12 months improves cognition in patients with hd. as primary outcome measure, the change of cognitive functions (as measured by the unified huntington's disease rating scale (uhdrs)-cognition composite score of stroop test, verbal fluency \& symbol digit modalities test) after 12 months in comparison to baseline was defined. the investigators further expect a positive influence of egcg on other clinical manifestations of hd, measurable effects of egcg on hd biomarkers and good safety and tolerability of egcg in hd patients.


Eligibility criteria:
inclusion criteria: * chorea huntington (cag repeats \>39) * uhdrs tfc \>5 * ≥18 years of age * readiness and ability to take oral medication * normal liver function laboratory test * stable concomitant medication regimen \> 4 weeks prior to baseline * motivation for women with childbearing potential to use highly efficient contraception exclusion criteria: * clinically relevant abnormal findings in the ecg, vital signs, physical examination or laboratory values at screening, * long-term treatment with potentially hepatoxic medication * any unstable medical condition * bdi depression score \> 9 and clinical diagnosis of depression * suicidal tendencies * cognitive dysfunction defined as a score \< 23 in the mini-mental state examination (mmse) at screening * liver or renal disease * schizophreniform psychosis within the last 6 months before baseline * consumption of more than two cups of black tea per day, consumption of green tea, consumption of \> 500 ml /day of grapefruit juice * participation in other arzneimittelgesetz (amg) or medizinproduktegesetz (mpg) studies (three months before and during participation) * pregnancy/ lactation

Keywords: huntington disease cognition motor behaviour functional capacity quality of life biomarker mri huntingtin egcg
longitudinal study on the influence of iodine nutrition status on thyroid function of childbearing age women during pregnancy and 6 weeks postpartum

Conditions: Thyroid Function; Iodine Nutrition Status

Summary: the goal of this observational study is to provide a reference for formulating individual appropriate iodine intake programs for women during pregnancy and postpartum and improving the monitoring and evaluation system of maternal iodine nutrition status. the main questions it aims to answer are: * to analyse the longitudinal changes of urinary iodine, urinary iodine/creatinine ratio, thyroid function and related factors in different periods of early, middle, late pregnancy and 6 weeks postpartum in beijing area. * to explore the relationship between iodine nutrition status and the changes of thyroid function and to further clarify the effect of iodine nutrition status on thyroid function of women of childbearing age during pregnancy and postpartum in combination with dietary intake of iodine questionnaire. participants will be detected there thyroid function, the level of median urinary iodine and urinary iodine/creatinine. researchers will compare healthy women of childbearing age served as the control group in the same period.


Eligibility criteria:
8-12 weeks healthy maternal: inclusion criteria: * primigravida * no chronic hypertension, thromboembolic disease, severe gastrointestinal, cardiopulmonary and liver diseases before pregnancy * no systemic lupus erythematosus, rheumatic diseases and other connective tissue diseases or immune diseases before pregnancy * no adrenocortical hyperplasia, pituitary endocrine diseases and other diseases before pregnancy exclusion criteria: * multiple pregnancies and multigravida * a history of type i or type ii diabetes before pregnancy * a clear history of thyroid diseases before pregnancy * taking drugs that affect thyroid function and/or blood sugar before or during early pregnancy healthy women of childbearing age: inclusion criteria: * 20-40 years old * no chronic hypertension, thromboembolic disease, severe gastrointestinal, cardiopulmonary and liver diseases * no systemic lupus erythematosus, rheumatic diseases and other connective tissue diseases or immune diseases * no adrenocortical hyperplasia, pituitary endocrine diseases and other diseases exclusion criteria: * a history of type i or type ii diabetes * a clear history of thyroid diseases * taking drugs that affect thyroid function and/or blood sugar
a study to assess safety and effectiveness of medrol in contact dermatitis in indian patients

Conditions: Dermatitis, Contact

Summary: this study will be a prospective, non-interventional, single arm and open label study, in patients with contact dermatitis requiring systemic steroid therapy with a purpose to obtain the real life effectiveness and tolerability of medrol in treating contact dermatitis in indian patients. patients with contact dermatitis who have been prescribed for medrol will be enrolled into the study and will be followed up for the resolution of symptoms


Eligibility criteria:
inclusion criteria: * to be eligible for enrollment in this study, patients must be prescribed oral medrol tablets (4mg and 16 mg) for contact dermatitis as per the locally approved prescribing information * medrol tablets, will be prescribed to the patient by the physician according to his/her usual practice. the decision to prescribe medrol tablet will necessarily precede and will be independent of the decision to enroll patient into the study * only those patients, who are ready to sign an informed consent, will be included in the study * subject can be contacted through telephone exclusion criteria: * patients who have any other dermatological or systemic condition that may interfere or confound with the study outcome measurements * patients taking any oral steroid preparation or immunomodulators or have taken any such oral medication during last 15 days before enrollment. nsaids (non steroidal anti-inflammatory agents) are excluded from the list * any contraindication to medrol tablet use. contraindications of medrol use are systemic fungal infections and known hypersensitivity to components * participation in other studies within last 1 month before the current study begins and/or during study participation * other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study

Keywords: contact dermatitis allergic dermatitis
evaluation of proprioception in patients treated with surgical external ankle ligament recontruction for traumatic ankle instability

Conditions: Ankle Sprains; Instability, Joint

Summary: the objective of the study is to evaluate post-operatively the postural control through the delos system with the riva method of patients already treated surgically of external capsulo-ligament reconstruction due to ankle instability.

the patients will then be divided into two control groups: one group will undergo reconditioning through the delos system and one group will undergo standard rehabilitation treatment. primary outcome: improvement of joint stability and postoperative proprioception after reconditioning with the delos system. secondary outcomes: improvement of performance indicators and reduction of disability and satisfaction and assessment of long-term ankle stability after reconditioning with delos system.

Eligibility criteria:
inclusion criteria: * patients already undergoing surgery and with at least 4 months of follow-up; * patients of both sexes aged between 18-40 years; * patients who have given their informed written consent to participate in the study; * patients who have given the willingness to reach the hospital to carry out the checks. exclusion criteria: * patients with bmi\> 30 kg / m2; * patients with rheumatoid arthritis; * patients with chronic inflammatory joint diseases; * patients with pre-existing deambulation kinematics abnormalities (amputations, neuro- muscular diseases, polio, hip dysplasias); * patients with severe arthrosis of the ankle (kellgren-lawrence\> 3); * patients with severe knee arthritis (kellgren-lawrence\> 3); * patients with severe postural instability; * patients with cognitive impairments; * patients with concomitant neurological diseases.

Keywords: ankle instability stabilometry
natural course for renal function after heart transplantation

Conditions: Creatinine Clearance Quantitative Trait Locus

Summary: the outcome of heart transplantation has improved by years. the renal dysfunction is a major complication after heart transplantation.the natural course of renal function following orthotopic heart transplant is not clear in taiwan. a retrospective study was conducted on patients who received a heart transplant at national taiwan university hospital between 1987 and 2015.

the investigators conducted a retrospective cohort study of patients who received a first heart transplant at the ntuh(taiwan) between 1987 and 2015 . clinical data were obtained and a retrospective chart review, and were collected up to 10 years . data was collected from medical records and the heart transplant electronic database including: demographic parameters such as age and gender; etiology of heart failure; the presence of any of the following comorbidities: history of smoking, diabetes, hypertension, peripheral vascular disease and previous sternotomy; pre-transplant cholesterol levels; the use of any of the following pretransplant hemodynamic support measures:intravenous inotropes, intra-aortic balloon pump and ventricular assist device;creatinine levels; listing status according to the unos classification; waiting time; heart ischemic time;immunosuppression drug levels(cyclosporine,prograft or certican) and development of end stage renal disease requiring onset of dialysis therapy. creatinine levels and gfrwere collected before transplantation and then the closest level to every month after heart transplant. the clinical outcomes of interest analyzed in this study included the development of post-transplant end stage renal disease and death.

Eligibility criteria:
this study included patients with a first htx performed at ntuh between1987 and 2015. patients were excluded if their first htx was a combined transplant involving a ktx, they had renal replacement therapy prior to their htx.

Keywords: heart transplant renal insufficiency
smartphone addiction and isometric strength of rotator cuff muscles

Conditions: Healthy Volunteer

Summary: to investigate the relationship between smartphone addiction and isometric rotator cuff muscles strength among adults

smartphones play an important role in human life because they are used for communication, accessing the internet, and gaming. the rate of smartphone usage has increased over the last decade, as has the duration and frequency of use. according to one study, 79 percent of people aged 18 to 44 spent almost all of their time on their smartphones, with only two hours of the day spent without one. no previous study has found a link between smartphone addiction and isometric rotator cuff muscular strength, to the authors' knowledge. therefore, the primary purpose of this study will be to determine the relationship between smartphone addiction and isometric rotator cuff muscles strength.

Eligibility criteria:
inclusion criteria: - 1- this study will comprise healthy volunteers between the ages of 18 and 30 who needed to use a smart phone. 2- subjects who put in more than 4 hours per day using smartphone. exclusion criteria: * patients will rule out if 1. they had any medical condition that could cause shoulder pain (such as impingement, subacromial bursitis, rotator cuff damage, or traumatic or degenerative supraspinatus tendonitis). 2. anyone with a positive neer sign, a positive hawkins sign, discomfort during shoulder elevation, pain at the location of the rotator cuff tendon, pain with resisted isometric shoulder abduction, or a history of pain in the c5 dermatome will be ruled out. 3. any individual who had previously suffered a musculoskeletal injury or surgery that could have influenced the measurement will be also eliminated.
efficacy and safety of uc-mscs for the treatment of steroid-resistant agvhd following allo-hsct

Conditions: Graft Vs Host Disease

Summary: randomized, open-label, multicenter study to investigate the efficacy and safety of umbilical cord-derived mesenchymal stem cells (uc-msc) for the treatment of steroid-resistant acute graft-versus-host disease (agvhd) following allogeneic hematopoietic stem cell transplantation (allo-hsct), with a view to establishing an effective treatment protocol for steroid-resistant agvhd.

a total of 130 patients with steroid-resistant agvhd after allo-hsct are enrolled in this multicenter, randomized, controlled trial. patients were randomized to uc-msc + anti-cd25 monoclonal antibodies (mab) group and anti-cd25 mab group. the complete response (cr) rate after 4 weeks of treatment in the two groups will be compared. adverse events are also recorded throughout the study.

Eligibility criteria:
inclusion criteria: * 1.confirmed diagnosed steroid-resistant agvhd after allo-hsct. 2. neutrophile granulocyte (anc) ≥ 0.5 x 10\^9/l. 3. creatinine below 2 times normal upper limit . 4. willing and able to sign written informed consent. exclusion criteria: - 1. untoleratation of the treatment. 2. primary disease are not effectively controlled or are progressing. 3. active infection (bacteria, fungi, viruses ). 4. combined with dysfunction of multiple organ. 5. female patients who are nursing or pregnant, or who contemplate pregnancy during the study period. 6. patients who are deemed unsuitable for the study by the investigator.
validation of an exercise dvd for maintenance after pulmonary rehabilitation.

Conditions: Lung Diseases

Summary: the public health agency of canada estimates that over 3.5 million canadians live with chronic respiratory diseases, such as copd (chronic bronchitis and emphysema), asthma, sleep apnea, and lung cancer. nova scotia has been reported to have one of the highest rates of chronic lung disease among canadian provinces, likely a reflection of both the age of the population and high rates of exposures to occupational dusts and smoking. pulmonary rehabilitation is a multidisciplinary intervention, involving exercise and education for patients with chronic lung disease. pulmonary rehabilitation has been demonstrated to improve patient symptoms, exercise capacity, and quality of life while reducing health resource utilization. many studies have shown that the benefits of pulmonary rehabilitation tend to diminish over time after program completion. the best interventions to maintain the benefits of pulmonary rehabilitation remain unclear. the purpose of this study is to validate incorporation of an exercise dvd into a maintenance program after pulmonary rehabilitation. 100 subjects will be recruited over 2-years from pulmonary rehabilitation programs at capital health, with 50 individuals randomized to usual care following pr and 50 individuals randomized to usual care plus the exercise dvd. study subjects will be evaluated at time of enrolment in pulmonary rehabilitation, at completion of pulmonary rehabilitation and 6-months post- pulmonary rehabilitation. study outcome measures will include exercise capacity, exercise compliance, health-related quality of life, confidence with performing exercise, and satisfaction with the exercise dvd. the primary outcome measure will be a change in functional exercise capacity as determined by the distance walked in 6-minutes, a commonly used and validated assessment tool for patients with chronic lung disease.


Eligibility criteria:
inclusion criteria: * any participant enrolled in pulmonary rehabilitation program exclusion criteria: * patients who do not have access to a dvd player. * inability to commit to the study plan. * cognitive or language barriers interfering with completion of the study procedures

Keywords: pulmonary rehabilitation exercise therapy chronic lung disease self-efficacy
observational study for non-motor symptoms and treatment in parkinson's disease patients

Conditions: Parkinson Disease

Summary: this study is implemented to identify factors having an impact on improvement or exacerbation of non-motor symptoms, to provide information contributing to development of medical care in this field and improvement of patients' qol, and to clarify the association between the use of istradefylline and non-motor symptoms or qol.


Eligibility criteria:
inclusion criteria: * patients who have wearing off under treatment with levodopa-containing drugs administered at least three times daily * patients who have at least one non-motor symptom as a complication * patients at least 20 years of age at the time of consent * patients who have given written consent * patients who are receiving outpatient care exclusion criteria: * patients with dementia or a score of 23 or less on the mini-mental state examination (mmse) * patients, in the opinion of the investigator or subinvestigator, having conditions impairing the proper assessment of the mds-updrs or pdq-8 (e.g., patients who are receiving treatment for malignant tumor)

Keywords: parkinson disease