Kornimate/medical-research-clean huggingface dataset:
brief cognitive behavioral therapy versus crisis intervention therapy through telepsychiatry on psychiatric symptoms

Conditions: Anxiety; Depressive Symptoms; Post Traumatic Stress Symptoms; Perceived Stress

Summary: the purpose of this randomized controlled trial is to determine the effect of two behavioral interventions: brief cognitive-behavioral therapy and crisis intervention therapy through telepsychiatry, over the level of perceived stress, anxiety, depression and post-traumatic stress symptoms during the covid-19 pandemic in medical residents and medical staff at three hospitals in two cities of honduras.

the psychotherapeutic interventions are going to be delivered from june to august at each participating center. subjects will be allocated randomly in each of the two interventional arms independently by stratification in each participating center. the population for intervention will be medical staff from three different national hospitals in the frontline during the pandemic. after valid informed consent, a screening process will take place to identify symptoms as baseline evaluation using validated self-assessment tools delivered through electronic invitation. post-intervention measurements will take place at 3 and 6 months from baseline. intention to treat analysis and per-protocol analysis will take place. consort guidelines were followed.

Eligibility criteria:
inclusion criteria: * medical doctors and medical residents 18 years and older, from unah medical school and hospital de occidente. * medical doctors and medical residents whom during the initial screening show positive scores in patient health questionnaire-2 and generalized anxiety disorder scale-2 * access to internet and an electronic device exclusion criteria: * medical doctors and medical residents referring a history of psychiatric disorders * medical residents that belong to the psychiatry residency program * medical residents and medical doctors that have been diagnosed with covid-19 * medical doctors and residents whom during evaluations show severe symptoms of depression, anxiety and post-traumatic stress symptoms * medical doctors and residents with negative screening in patient health questionnaire-2 and generalized anxiety disorder scale-2 * participants that do not have access to internet connection or an electronic device.

Keywords: telepsychiatry cognitive behavioral therapy crisis intervention anxiety depression post traumatic stress
diuretics for postpartum high blood pressure in preeclampsia

Conditions: Preeclampsia

Summary: the purpose of this study is to determine if furosemide administered after the first 24 hours of delivery, in women with severe peeclampsia and eclampsia accelerates high blood pressure control and diminishes hospital stay.

a placebo-controlled study that will be conducted including 120 postpartum women with severe preeclampsia . women who are previosuly diuretic users, with renal impairment, hemodynamic instability or with contraindications to diuretic use will be excluded. informed consent will be obtained from all participants . patients will be randomized to receive furosemide ( 40mg orally every twenty-four hours ) or placebo for maximum of five days. the variables are systolic and diastolic blood pressure, frequency of very high blood pressure, need for maintenance of antihypertensive therapy , number of antihypertensive agents used to control blood pressure , urine output , length of hospital stay , adverse effects and maternal complications . except for the study drug, patients will receive all care and monitoring according to the hospital protocol and decision to initiate or modify antihypertensive therapy will be defined by the attending physician, as well as the decision to discharge. if the patient is discharged before five days of the protocol drug, this drug will be stopped. teh patients may decide to leave the study at any moment. data will be collected by researches daily. plan statistical analysis will be performed using the public domain program epi info 7.0 and the mean and dispersion measures for numerical variables will be calculated. to compare means obtained every day and between groups will be used analysis of variance ( anova ) . nominal variables were compared using the x2 test or fisher if necessary. be considered significant at p \< 0,05. the risk ratio (rr) is calculated as a measure of the relative risk for the different outcomes , according to furosemide or placebo

Eligibility criteria:
inclusion criteria: * preeclampsia * urine output \> 50ml/h * end of postpartum magnesium sulphate exclusion criteria: * cronic hypertension * bloor pressure \< 140mmhg and \< 90mmhg * diuretic use * renal impairment * diabetes, sickle cell disease ou rheumatologic disease * hemodinamic instability * potassium \< 3meq/l * contraindications for fusoremide use

Keywords: preeclampsia, very high blood pressure, diuretics
effect of high frequency/low intensity transcranial magnetic stimulation in cognitive traits of an elderly population of subjects with mild cognitive impairment and mild dementia.

Conditions: Mild Cognitive Impairment; Mild Dementia

Summary: there are no pharmacological interventions that delay or prevent the transition of mild cognitive impairment to dementia. several studies have shown that transcranial magnetic stimulation (tms) could be useful in increasing cognitive traits in dementia. as tms is performed in a clinical setting, transportation, mobility and high costs of treatment, limit the number of tms sessions dementia patients can receive. most of the trials do not apply more than 20 tms sessions here, a randomized, sham controlled, paralallel group, clinical trial will be performed in order to asess the efficacy at improving cognitive traits of a novel tms device that uses high frequency and low intensity pulses. as the device is portable and can be used from home without clinical supervision, the stimulation will be applied two times per day for a period of 6 months.


Eligibility criteria:
iinclusion criteria: ( - ) cdr less or equal to 1 ( - ) mild cognitive impairment by petersen criteria ( - ) conserved or corrected sight ( - ) enrolled at incmnsz for medical care ( - ) be able to read and write ( - ) willing and able to provide written informed consent exclusion criteria: ( - ) other neurodegenerative disorder different than mild cognitive impairment or mild dementia ( - ) metabolic disease without medical care ( - ) epilepsy ( - ) deep brain stimulator ( - ) metalic prosthethics in the skulls ( - ) major depressive disorder ( - ) previous utilization of other neuromodulation technique ( - ) signs or symptoms of increased intracraneal pressure
project to improve the diagnosis and treatment ability of adult severe community acquired lower respiratory tract infection

Conditions: CAP; COPD Exacerbation

Summary: 1. objective to understand the proportion of atypical pathogens in the pathogens of scap and aecopd in urban hospitals in china. 2. objective to investigate the antimicrobial resistance of atypical pathogens in patients with acute exacerbation of chronic obstructive pulmonary disease (copd) and scap in urban hospitals. 3. objective to master the important clinical characteristics of patients with acute exacerbation of scap and copd caused by atypical pathogens and mixed infection in urban hospitals in china, and to put forward the experience judgment index. 4. objective to evaluate the advantages of various diagnostic methods for atypical pathogens causing lower respiratory tract infection. 5. it is suggested that the current empirical treatment of scap and severe copd in china should be improved.


Eligibility criteria:
inclusion criteria: * scap * aecopd exclusion criteria: * pregnant or lactating women. * patients with bronchiectasis. * patients with active pulmonary tuberculosis. * aspiration pneumonia or obstructive pneumonia. * two weeks before the onset of hospital treatment history, this infection can not be excluded from hospital acquired infection. * hiv positive patients (but hiv testing is not required). * patients who are unable and / or unable to understand and / or implement the investigation protocol.
study of vx-765 in subjects with treatment-resistant partial epilepsy

Conditions: Partial Epilepsy

Summary: the purpose of this study is to determine the safety, tolerability, and efficacy of vx-765 in subjects with treatment-resistant partial epilepsy


Eligibility criteria:
inclusion criteria: * subjects that are male or female aged 18 to 64 years (inclusive) with a body mass index between 18 and 35 (kg/m2) * subjects must have a diagnosis and history of treatment resistant partial onset seizures for which they are taking 1 to 4 concomitant antiepileptic drugs (aed). treatment resistance is defined as failure to achieve seizure freedom despite adequate use of 2 different aeds. all aed doses must remain stable for 4 weeks prior to the screening visit and throughout the entire study * subjects must have had at least 1 electroencephalogram (eeg) consistent with partial epilepsy and a brain magnetic resource imaging (mri) or computed tomography (ct) scan within 5 years of screening visit negative for other confounding conditions * subjects must have had at least 6 observable partial seizures in 6 weeks prior to randomization, with at least 1 seizure per week during 3 of the 6 weeks within the baseline period * subjects who are male or female must agree to use acceptable contraceptive methods as defined in the protocol * subjects who are in otherwise good health exclusion criteria: * subjects with a history of non-epileptic transient alterations in consciousness * subjects who have a history of status epilepticus in the past 12 months * subjects whose seizure frequency cannot be quantified * subjects who have significant medical illness including kidney, liver, pulmonary or gastrointestinal disease; or unstable or poorly controlled conditions * subjects who have clinically significant psychiatric illness * subjects with a positive drug screen (excluding any allowed prescribed medications) and history of alcoholism or drug addiction within past 2 years * males subjects that have a female partner of childbearing potential who do not agree to use medically approved methods of birth control * male subjects that have a female partner who is pregnant, nursing, or is planning to become pregnant during the study period, or within 90 days of the last dose of study drug * female subjects who are pregnant or lactating, or who are of reproductive potential who do not agree to use medically approved birth-control methods * subjects with a current or prior history of illness precluding them from immunomodulatory therapy (e.g. history of recurrent infections) * subjects with active hepatitis b, hepatitis c, or human immunodeficiency virus (hiv) * subjects who have participated in any other clinical trials involving an investigational product or device and have received the last dose of study drug within 45 days or 5 half-lives of the screening visit
lllt for alopecia of the eyebrow in women

Conditions: Alopecia

Summary: the purpose of this research is to study the ongoing effectiveness of a light therapy device for human hair growth. this device, called the irestore eyebrow device, is a type of cold, or non-heat producing light therapy system that will emit light on the hair growth cells within and around the hair follicle. when these cells do not function properly, one may experience common problems such as baldness and thinning or brittle hair. the application of a special category of low-level light to be studied in the project may cause an increase in essential nutrients to the damaged hair follicles and skin cells, leading to a reduction in hair loss and in some cases, possibly leading to re-growth.

this study on lllt aims to define the safety and physiologic effects that occur when the human hair follicle and surrounding tissue structures are exposed to this type of radiation. thus far, all reports on the efficacy of laser light and led light in this area, have been, in large part, unsupported by multi-center, randomized, double blind, controlled studies. to properly identify the effects in human subjects, exposure to lllt is not sufficient. the analysis of the non-radiated and radiated tissues is required to elucidate the tissue response and efficacy of the laser therapy. the theory that is widely accepted is that the mitochondria are the powerhouse of the stem cells that cause hair growth. the lllt "turns on" the nutrient pump process that energizes the mitochondria, which leads to an increase in atp and subsequent reversal of hair follicles from the dormant stage of growth called telogen, to the active growth stage called anagen.

Eligibility criteria:
inclusion criteria: * female subjects experiencing any type of non-traumatic eyebrow hair loss. * apparent good health. exclusion criteria: * previous involvement in other eyebrow hair studies. * use of any hair growth agent within the last 4 weeks. * evidence of any current viral, fungal or bacterial infection.
effectiveness of pumpkin seed extract on improving blood sugar level in subhealth subjects

Conditions: Diabetes; Metabolic Disease

Summary: this randomized, double-blind, placebo-controlled, and parallel clinical study aims to investigate the effectivness of a pumpkin seed extract on blood sugar management in subhealth people.


Eligibility criteria:
inclusion criteria: * fasting blood sugar levels from 100 to 125 mg/dl * glycated hemoglobin levels from 5.7 to 6.4% * 2-hour ogtt levels from 140 to 199 mg/dl exclusion criteria: * pregnant women or preparing for pregnancy. * lactating women. * women gave birth 6 months before the study. * poor kindy funciton * severe cardiovascular or other chronic diseases * patients with type i or ii diabetes * poor compliance * alcohol abuser * using anti-diabetic or weight managent supplements * blood transfusion three months before the study * pumpkin seed allergy
clinical outcome at 5 years after implantation of the liberty677my multifocal intraocular lens

Conditions: Cataract

Summary: the study will assess visual outcomes, light disturbances and patients' satisfaction after implantation with the liberty677my multifocal iol, as well as protection of pco development within 5 year follow-up.

the liberty677my multifocal iol is designed for restoring near, intermediate and distance vision. the technology of liberty 677my is based on the elevated phase shift technology (patent pending). previous evaluations showed the strength of studied iol both in laboratory and clinical conditions. patients will be examined 5 years after implantation. the examination will include the measurement of the best corrected distance, intermediate and near visual acuity (assessed with early treatment diabetic retinopathy study (etdrs) charts), intraocular pressure (contact goldman tonometry), biomicroscopic and fundocsopic examination, contrast sensitivity (csv-1000), defocus curve, reading capability, pupilometry in different light conditions and pco evaluation, nd:yag capsulotomy rate, photo-documentation of anterior segment. yag capsulotomy will be indicated in case of posterior capsule opacification (pco). the criteria for yag capsulotomy will be visual acuity decreased 2 or more lines when using (etdrs) charts. details of all related and unrelated complications will be documented, including severity, time of onset, specific treatment and clinical outcome. the investigators will also record whether the capsulorhexis is on or partially off the optic.

Eligibility criteria:
inclusion criteria: * pseudophakic patients implanted with liberty 677my in 2014-2015 during the study under the ethical approval: 059823/2014/otig exclusion criteria: * diabetic retinopathy * iris neovascularisation * serious intraoperative complications * congenital eye abnormality * glaucoma * pseudoexfoliation syndrome * amblyopia * uveitis * long-term anti-inflammatory treatment * amd (advanced amd) * retinal detachment * prior ocular surgery in personal medical history (except cataract surgery aiming the implantation of the multifocal iol) * previous laser treatment * corneal diseases * severe retinal diseases (dystrophy, degeneration) * severe myopia (if required iol power is lower than 10 d) * inadequate visualization of the fundus on preoperative examination * patients deemed by the clinical investigator because of any systemic disease. * pregnancy * eye trauma in medical history * current use of systemic steroids or topical ocular medication * preoperative smaller pupil size of 6 mm under topical mydriasis * kappa angle \>5°
18f-fdg pet/ct-based prognostic model for predicting outcome in patients with natural killer/t-cell lymphoma

Conditions: Lymphoma, Extranodal NK-T-Cell

Summary: the purpose of this study is to evaluate whether 18f-fdg pet/ct-based prognostic model of nk/t-cell lymphoma can predict disease progression

in this study investigators develop a prognostic model based on 18f-fdg pet/ct and test its ability for prognostic value in patients with dlbcl. pet/ ct scans evaluation using the liver suvmax as reference. positive lesions in pet were indicated as suvmax of residues higher than the threshold or new 18f-fdg avid lesions. 18f-fdg pet/ct-based prognostic model includes pet/ct image, dominant clinical and pathological prognostic factors to predicting disease progression during chemotherapy or survival in nk/t-cell lymphoma.

Eligibility criteria:
inclusion criteria: * newly diagnosed nk/t-cell lymphoma * treated using an anthracycline-containing regimen * minimal follow-up at 6 months after the completion of first-line treatment * complete medical history and clinicopathological data exclusion criteria: * secondary malignant disease * serious infection or inflammation (e.g., hiv) * primary central nervous system lymphoma * hepatic or renal dysfunction.

Keywords: lymphoma, extranodal nk-t-cell positron-emission tomography prognosis
influence of educational stimuli from the pé-de-meia program on delay discounting propensity

Conditions: Delay Discounting

Summary: the goal of this randomized clinical trial is to investigate how the stay-and-complete school incentive savings, part of the pé-de-meia program, affects decision-making among low-income high school students, particularly their tendency towards delay discounting. this concept describes the preference for immediate gratifications over larger future rewards. the main questions it seeks to answer are: can exposure to the specific educational stimuli of the pé-de-meia program alter students' propensity for delay discounting? how do different levels of delay discounting influence students' decision-making regarding their studies and the utilization of the program's incentives? participants will: engage in a modified version of the iowa gambling task (igt), a computerized game that simulates decision-making under uncertainty, adapted to reflect the stimuli and choices related to the pé-de-meia program. complete questionnaires that measure their propensity for delay discounting and gather demographic and socioeconomic information. researchers will compare the outcomes among groups of students exposed to different types of stimuli (aligned with the program's objectives, contrasting, and a control group without modifications) to see if the specific financial and educational incentives of the pé-de-meia program influence how students value immediate rewards compared to future benefits. this study is expected to contribute to the improvement of public educational policies, encouraging school retention and promoting the educational success of low-income adolescents.


Eligibility criteria:
inclusion criteria: * low-income high school students in the public system, registered in cadúnico exclusion criteria: * students with a formal psychological or psychiatric diagnosis
laparoscopic appendectomy for chronic right lower abdominal pain

Conditions: Chronic or Recurrent Appendicitis

Summary: it is questionable whether elective appendectomy can effectively reduce pain in persistent or recurrent lower abdominal quadrant pain due to chronic appendicitis. a single centre randomised double-blind sham surgery controlled clinical trial studied the effects of elective laparoscopic appendectomy on postoperative pain perception in patients with persistent or recurrent lower abdominal quadrant pain on abdominal pain at 6 months postoperatively. secondary outcome was the relation between clinical response and the appendix' histopathology. the analysis was performed on an intention-to-treat basis. pain scores were compared using a fisher's exact test.

forty patients were randomised, 18 patients had a laparoscopic appendectomy and 22 patients had a laparoscopic inspection only. the postoperative pain scores were significantly different favouring appendix removal (p \< 0.01). relative risk calculations indicated a 2.4 fold (95% ci: 1.3 - 4.0) greater chance of improving or becoming pain free after laparoscopic appendectomy. the number needed to treat was 2.2 patients (95% ci: 1.5 - 6.5). there was no significant relation between postoperative pain scores and histopathology findings. conclusions chronic or recurrent appendicitis is a realistic clinical entity that can be treated successfully by elective appendectomy leading to significant pain reduction in properly selected cases. histopathology of the removed appendix does not contribute to the diagnosis.

Eligibility criteria:
inclusion criteria: * patients were eligible if they were between 15 and 45 years of age, and if they suffered from chronic or recurrent right lower abdominal quadrant pain for more than three months. they were to experience continuous pain, or should have endured at least one pain attack in the month prior to inclusion. exclusion criteria: * exclusion criteria consisted of (a history of) chronic back pain, previous abdominal surgery (with the exception of diagnostic laparoscopies or a laparoscopic sterilization), specific gastro-intestinal entities (such as inflammatory bowel disease) and gynaecological disease (all female patients consulted a gynaecologist). routine laboratory investigations included hemoglobin rate, serum leukocyte count and differentiation, c-reactive protein concentration, erythrocyte sedimentation rate, faeces cultures and urine sedimentation. barium contrast studies of the colon were done in all patients, abdominal ultrasound or enteroclysis on discretion. finally, exclusion was possible when diagnostic laparoscopy revealed abnormalities (see below).

Keywords: abdominal pain appendectomy laparoscopy chronic appendicitis appendicopathy
professional bladder cancers and the profession of painter

Conditions: Bladder Cancer

Summary: this is a retrospective study on bladder cancer in french painters' population. the french agency anses collected data from all occupational and environmental diseases center in a specific database called rnv3p. we selected cases of bladder cancer in painters in four centers from 01/01/2010 to 31/12/2019. those cases were analyzed in terms of occupational exposure, histology and sociodemographics data. comparison between different histologic types of cancer, workplaces and occupational diseases process will be done.


Eligibility criteria:
inclusion criteria: * painters * age\> 18 years * data from one of the french occupational diseases centers * approval letter exclusion criteria: * non-approval letter * age \< 18 years

Keywords: painter occupational cancer