Kornimate/medical-research-clean huggingface dataset:
effects of vlckd in metabolic syndrome

Conditions: Diabetes Mellitus, Type 2; Non-alcoholic Fatty Liver Disease; Obesity; Metabolic Syndrome

Summary: vlckd has showed to be an impactful diet on several metabolism aspects and has proven to be useful for preventing and treating diabetes mellitus type 2, overweight, chronic inflammation and fatty liver. for this reason, the aim of this pilot study is to examinate the potential effect of a vlckd on a group of patients that contemporarily have dm2, obesity and non alcholic fatty liver disease (nafld), comparing the results with an ipocaloric diet based on mediterranean principles and italian larn (sinu 2014). this study will consider several interrelated outcomes such as anthropometric data, hematochemical and hormonal parameters, questionnaires, stool microbiota and omics, blood microvescicles, urine tests, instrumental tests (dxa, biva, ecographies), biopses and functional tests. 40 subjects will be evaluated and divided in two groups of 20 (vlckd) and 20 (meddiet).


Eligibility criteria:
inclusion criteria: * age 25-65 * bmi 30-40 mg/m2 * nafld * dm2 drug-treated (metformin, sglt2 inhibitors, glp-1 analogues, dppiv inhibitors, basal insulin) and hba1c \> 7 and \< 10 %. exclusion criteria: * secondary obesity due to genetic or endocrinologic causes. * renal disease with egfr \< 45 ml/min/1.73m2 or macroalbuminuria or calculosis * insulin basal + bolus or hba1c% \>10.0% * other types of dm * ipopituitarism or adrenal insufficiency * antibiotics use less than 3 months before the first visit
establishing normative data for pupillometer assessments in neuro-intensive care

Conditions: Critical Illness; Neuropathy

Summary: the purpose of this study is to collect a large amount of data that may assist in addressing the gap in knowledge of understanding pupillometer readings using a pupillometer device. the aim of this project is to establish normative values for pupillometer data. measures of central tendency will be developed for the variables provided by automated pupillary exams, which will provide an enhanced understanding of clinically appropriate pupil values for size, reactivity, and neurological pupil index.

data will be collected on patients in the intensive care units at the selected hospitals on patients who have been assigned, by the attending physician, to have regular pupillary assessments, and in whom staff nurses are performing pupillary assessments with the pupillometer. while a sample size estimate would be considered inappropriate for registry development, power analysis techniques were used to examine the potential of this registry to generate adequate information to begin to fully describe normative data for pupillary exams. using the assumption that the desire is to understand neurological pupil index (npi) and size differences within 0.1, and that the spread of data would be approximately normally distributed, a minimum of 3,250 observations is required (alpha = 0.05, beta = 0.80). it must, however, be repeated that this is simply a rough estimate. the registry data generated will, in fact, be the source of data from which future studies will be powered.

Eligibility criteria:
inclusion criteria: * data will be collected on patients admitted to enrolling hospitals who have been assigned, by the attending physician, to have regular pupillary assessments, and in whom staff nurses are performing pupillary assessments with the pupillometer. exclusion criteria: * out-patients * patients that do not have orders for regular pupillary assessments
carpal tunnel release using ultrasound

Conditions: Carpal Tunnel Syndrome

Summary: the goal of the carpal tunnel release using ultrasound registry (citrus registry) is to collect experience information from patients scheduled to undergo carpal tunnel release surgery with either the sx-one microknife® with ultrasound guidance or the traditional mini-open technique without us guidance.

the citrus registry is an observational study designed to better understand the overall patient experience following a carpal tunnel release surgery using either the sx-one microknife with ultrasound guidance or the traditional mini-open technique without ultrasound guidance. the determination of which surgical technique to uses will be determined by the treating physician and the patient. the patient registry outcomes are intended to help direct future clinical care, educate patients with carpal tunnel syndrome, and design future research.

Eligibility criteria:
inclusion criteria: * scheduled to undergo carpal tunnel release surgery on the right and/or left wrist using either the sx-one microknife with us guidance or the traditional mini-open technique without us guidance * 18 years of age or older * agree to complete questionnaires over a 12-month period * valid mobile phone number and email address to receive and answer questions exclusion criteria: • age less than 18 years

Keywords: carpal tunnel release ultrasound
open-label trial of imatinib mesylate in patients with unresectable recurrent glioblastoma multiforme expressing pdgfr (platelet derived growth factor receptors)

Conditions: Glioblastoma

Summary: this is an open label clinical trial of imatinib mesylate 800 mg po/day in a population of patients with unresectable, recurrent glioblastoma multiforme. patients will be treated for up to 12 months


Eligibility criteria:
inclusion criteria: 1. histologically documented diagnosis of gbm. 2. immunohistochemical documentation of expression of pdgfr. 3. unresectable, recurrent disease by mri and spectroscopy exclusion criteria: 1. treatment with any other investigational agents within 28 days of first day of study drug dosing. 2. concurrent chemotherapy. 3. concurrent radiotherapy. other protocol-defined exclusion criteria may apply.

Keywords: glioblastoma brain tumors imatinib pdgfr
regional anesthesia block in fibula free flap reconstruction

Conditions: Anesthesia, Local; Surgery; Opioid Use; Pain, Postoperative; Head and Neck Neoplasms

Summary: despite many recent advances in pain management, post-operative pain is widely considered to be poorly managed. furthermore, the mainstay of current pain management is opioids, for which there is strong evidence of ill effects and long-term potential for addiction. there are many studies demonstrating that perineural regional anesthesia can be superior to intravenous opioid analgesia, and that the technique is safe. by using temporary implanted catheters, this method can now deliver prolonged analgesia, thus reducing the need for opioids in the postoperative period. regional anesthesia is a proven technique and used daily by anesthesiologists, and it is also the first choice for hip and knee replacement surgery for orthopedic surgeons. patients undergoing head and neck reconstruction with the use of free tissue transfer experience a significant amount of post-operative pain due to the complexity of the surgery, the presence of a head and neck surgical site as well as a secondary donor site, and existing co-morbidities, most commonly malignancy, that also cause significant pain. these patients often require opioids for pain control throughout the hospital stay, and are almost always discharged home with additional opioids. by utilizing regional anesthesia blocks at the donor sites, the investigators can potentially reduce post-operative pain while also reducing the use of opioids.


Eligibility criteria:
inclusion criteria: * subjects undergoing microvascular fibula free flap reconstruction of the head and neck * subjects undergoing primary or secondary reconstruction exclusion criteria: * subjects needing elevation of care to the intensive care unit due to remaining intubated for extended period of time or other complications during the peri or post operative period * subjects with surgical complications requiring significant alteration of the treatment plan o subjects requiring a return to the operating room during admission will be excluded, unless it is for a procedure not related to the original surgery occurring after post op day 3, such as a gastrostomy tube or long term iv access. * subjects with true allergies to the study drugs * subjects undergoing reconstruction with more than 1 free flap, or with the use of any additional regional flaps * history of substance dependence or enrollment in a pain management program * any subject currently enrolled in pain management, or currently taking long acting opioids such as methadone or oxycontin. * subjects who do not stay in the hospital for at least 4 days post operatively * subjects requiring anticoagulation will not require modifications prior to receiving regional anesthesia. * inability to properly place catheter or administer the regional anesthesia
refining cough skill training in parkinson's disease and dysphagia

Conditions: Parkinson Disease; Dysphagia

Summary: airway protection deficits (cough and swallowing) are prevalent and pervasive in parkinson's disease (pd), contributing to adverse health outcomes like pneumonia. this study aims to refine cough skill training by examining whether variable versus constant practice conditions improve cough outcomes in people with pd. in addition, this study will provide insight into optimal respiratory adaptations that occur during training to support cough effectiveness, resulting in immediately translatable treatments to improve airway protection-related health outcomes in people with neurodegenerative disease.


Eligibility criteria:
inclusion criteria: * 40 years of age or older * have dysphagia as documented by a penetration-aspiration score \> 2 on a flexible endoscopic evaluation of swallowing * have cough disorder as defined as a maximal voluntary cough peak flow \< 5 l/s * have no history of other neurological disorders, head and neck cancer, respiratory disease, smoking within 5 years, uncontrolled hypertension, or allergy to capsaicin (reflex cough stimulus) exclusion criteria: * unable to participate due to neuropsychological dysfunction (i.e., dementia with a score of \< 19 on the montreal cognitive assessment) * actively participating in other cough or swallowing treatments
occult hcv infection after daad treatment in haemodialysis patients

Conditions: Hepatitis C

Summary: this research aims to evaluate the prevalence and predictors of occult hcv among hemodialysis (hd) patients who achieved 24 weeks sustained virological response (svr) after treatment with direct-acting antiviral agents (daa) by detection of viral rna in their peripheral blood mononuclear cells.

in maintenance hemodialysis (mhd) patients, hepatitis c virus (hcv) infection is common and may be associated with poor clinical outcomes. a lot of treatment options for hcv have rapidly evolved over the past 5 years and various treatment choices for patients with advanced ckd are currently available.1 the reappearance of hcv infection months or years after sustained virologic response (svr) may be due to the persistence of hcv in tissue cells in spite of being undetected in serum. this situation is known as occult hepatitis c infection (oci).2 oci is now a challenging entity in the field of post hepatitis management and follow-up. oci is described when hcv-rna is detectable in liver and/or peripheral blood mononuclear cells (pbmcs) in patients with undetectable serum hcv-rna. to our knowledge , this is the first research to issue this problem in dialysis patients after treatment with direct acting antiviral drugs.

Eligibility criteria:
inclusion criteria: * patients on regular hemodialysis treatment for more than 6 months. * achieved sustained virological response 24 weeks after the end of treatment with directly acting antiviral drugs (daads). exclusion criteria: -

Keywords: occult hcv, direct antiviral drugs, haemodialysis
balance acceptance and commitment therapy for long covid

Conditions: Post-COVID-19 Syndrome; Long COVID

Summary: this randomised controlled trial aims to investigate the efficacy of a psychological intervention for long covid (lc) / post-covid-19 syndrome (pcs) called balance acceptance and commitment therapy (balance act). the primary objective of this trial is to investigate whether balance-act improves quality of life over treatment as usual (i.e., self-help leaflet) in people with pcs/lc.


Eligibility criteria:
inclusion criteria: 1. age 18 or older 2. lc/pcs diagnosis as defined by national health service (nhs) / national institute for health and care excellence (nice) (i.e., symptoms that develop during or after an infection consistent with covid-19, continue for more than 12 weeks and are not explained by an alternative diagnosis). a checklist will be used to ensure participants fulfil the diagnostic criteria as per the nice guidelines 3. ability to travel to the research site for the study assessments 4. consent to wear a smartwatch throughout the study 5. having registered with a general practitioner (gp) in the united kingdom (uk) and consent to provide their details for the study team to contact 6. ability to provide informed consent 7. ability to read and write english exclusion criteria: 1. current diagnosis of an active major mental health disorder likely to interfere with participation 2. unstable alcohol / drug dependency 3. unstable complications associated with lc/pcs 4. past hospitalisation for covid-19 5. current or recent participation in other treatment intervention studies (\<4 weeks after completion) 6. currently receiving psychological support or psychotherapy 7. implanted medical devices (ie., pacemaker/defibrillator or implanted neurostimulator/infusion device; implanted metal objects; artificial hip/knee replacement, spinal surgery; cardiac surgery requiring the placement of metal clips, valves or wires) 8. pregnancy
application of two different synthetic sequential media for the human ivf-embryo transfer (ivf-et) program

Conditions: Infertility

Summary: quality-controlled commercial media have been used in many in-vitro fertilization (ivf) laboratories. however, commercial media are costly and difficult to compare directly because their exact compositions are not clearly indicated. although commercially available media have commonly been used in most ivf programs worldwide, there are several advantages to the use of in-house synthetic sequential media at ivf laboratories. first, the results of quality control should be reliable due to a stringent protocol setting-up. second, any direct supplementations or deletions of specific components are feasible to obtain good quality embryos and high pregnancy rates since those components can be defined. finally, dependence on commercially available media diminishes so that the laboratory can more easily accommodate unexpected situations or problems, such as a sudden increase in ivf patients. therefore, the present study was conducted to compare the efficacy of in-house mrc media in the human ivf-embryo transfer (et) program to that of commercially available media.


Eligibility criteria:
inclusion criteria: * patients undergoing ivf treatment in our clinic during study period exclusion criteria: * females older than 40 years * patients showed fertilization failure * patients with less than two 2pn embryos
transversus thoracic muscle plane combined with pectoral nerves block for breast cancer surgery

Conditions: Breast Cancer

Summary: this is a prospective, randomized, controlled trial for evaluating the efficacy of addition of transversus thoracic muscle plane block to pectoral nerves block versus pectoral nerves block for quality of recovery scores in breast cancer surgery.

the pectoral nerves (pecs) block cannot block the most internal mammary region, whereas a transversus thoracic muscle plane (ttp) block can. the combination of pecs and ttp blocks may be suitable for breast cancer surgery. we studied patients undergoing breast cancer surgery to assess whether the combination of pecs and ttp blocks provides better postoperative recovery than pecs block alone.

Eligibility criteria:
inclusion criteria: * female, 18-80 years of age * american society of anesthesiologists physical status i-iii * patients having elective unilateral breast cancer surgery exclusion criteria: * contraindication to nerve block * inability to understand or communicate with research personnel * chronic use of opioids or nonsteroidal anti-inflammatory drugs * pregnancy
high intensity intervallic training in children with bronchiolitis obliterans

Conditions: Bronchiolitis Obliterans

Summary: post-infectious bronchiolitis obliterans (pibo) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection. this disease is diagnosed mainly in children, more frequently before the age of 2 years. due to symptoms such as dry cough and dyspnea sensation, most of these patients have low levels of physical activity compared to healthy individuals. physical activity can positively influence oxygen consumption, muscle strength, and quality of life. high levels of oxygen consumption are associated with a lower risk of respiratory disease and hospitalization. high-intensity interval training (hiit) may be an effective way to improve oxygen consumption, muscle strength, and quality of life in patients with chronic diseases. hiit has been shown to produce less dyspnea sensation and to be more entertaining in children and adolescents with respiratory disease compared to continuous training. thus, the investigators propose to perform telematically real-time guided training to reduce travel times and additional costs to patients. objective: to analyze the effects of a telematically supervised high-intensity intervallic training program on aerobic fitness, as well as functional/clinical outcomes in patients with pibo. methods: randomized controlled trial with two groups. exercise group: 16-week hiit training conducted telematically; control group: will follow the routine physician's recommendations. patients will be recruited at vall d'hebrón university hospital (barcelona), niño jesús university hospital (madrid), and donostia universitary hospital (san sebastián). criteria for participation: (i) diagnosis of pibo; (ii) clinically stable at the time of the assessments; (iii) age between 6 to 20 years old.


Eligibility criteria:
inclusion criteria: * diagnosis of postinfectious bronchiolitis obliterans; * clinical stability at the time of the assessments; * age between 6 and 20 years old. exclusion criteria: * symptoms of pulmonary exacerbation during the last four weeks; * diagnosis of other cardiorespiratory diseases leading to symptoms of persistent respiratory dysfunction; * difficulty in comprehension or musculoskeletal alterations that may influence the assessments; * pregnancy; * transplant list inclusion.

Keywords: high intensity interval training post-infectious bronchiolitis obliterans telematic program cardiorespiratory fitness
prevalence of lymphoma in ibd

Conditions: Lymphoma; Inflammatory Bowel Disease

Summary: patients with inflammatory bowel disease (ibd) may be at increased risk of lymphoma. the majority of lymphomas in patients with ibd occur in areas of active inflammation. the relationship between ibd and lymphoproliferative disease is however unclear, since both chronic inflammation as well as medications used to treat ibd (especially immunosuppressives - azathioprine or 6-mp - and anti-tnf alpha agents) have been associated with increased risk of lymphoma. we plan to study the association between ibd and lymphoma in a large, mixed, community based and referral population from the ibd database at indiana university.


Eligibility criteria:
inclusion criteria: * inflammatory bowel disease * lymphoma
safety observation on hesc derived msc like cell for the meniscus injury

Conditions: Meniscus Injury

Summary: human embryonic stem cell derived mesenchymal stem cells like cell for the meniscus injury, and observe the safety of the cells for meniscus injury

three different dosage of human embryonic stem cell derived mesenchymal stem cells like for meniscus injury patients, and observe the safety of the cells for meniscus injury.

Eligibility criteria:
inclusion criteria: * grade ⅰ-ⅱ meniscus injury of knee joint * the patients who still have the pain of knee joint and/or limitation of the function after accepted 3 months of nonoperative treatment exclusion criteria: * recent history of lower limb fractures or intra-articular drug injection * the patients who have meniscus injury of knee joint need the surgical repair * the patients who have the severe coagulation disorders, cardiopulmonary failure and so on * the women who are pregnant or nursing * there are electronic implants such as pacemakers in the body * the patients who are infected the hiv, the virus of hepatitis or syphilis * the patients who are alcoholism or drug user * the patients who have vestibular and balance disorders * the patients with severe cognitive impairment who cannot follow instructions to complete the treatment * the patients who don't sign the informed consent * the patients who have tumor * immunodeficiency patients * the patients who have congenital or acquired knee malformation * patients or researchers who are participating in other clinical trials believe that other reasons are not appropriate for clinical trials
telephone counselling to promote physical activity in diabetes mellitus people

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to investigate the effects of phone counselling support as a strategy to increase physical activity in people with diabetes.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of type 2 diabetes mellitus * age between 18 and 80 years * both sexes * medical recommendation for physical activity * ability to listen and answer questions * have cell phone and/or residential * be registered the center for family health 03 in 2012 * people should also produce higher frequency than 75% stake in the proposed activities diabetes education group and telephone counseling exclusion criteria: people who do not attend the criteria for inclusion. * did not have clinical diagnosis of type 2 diabetes mellitus * did not have age between 18 and 80 years * did not have medical recommendation for physical activity * did not have ability to listen and answer questions * did not have cell phone and/or residential * do not be registered the center for family health 03 in 2012 * people who did not participate in 75% of the activities of the group proposed the diabetes education and telephone counseling

Keywords: diabetes mellitus telephone physical activity