Kornimate/medical-research-clean huggingface dataset:
spontaneous gastric intramural hematoma: case report and literature review

Conditions: Gastric Hemorrhage

Summary: patient previously healthy found to have spontaneous gastric intramural hematoma

28 year old male patient previously healthy presented with diarrhea and diffuse abdominal pain of 1 week duration that exacerbated 1 day prior to presentation. ct showed anterior abdominal mass possibly from the outer gastric wall. gastroscopy suspected a submucosal tumor in the body and antrum. patient's pain exacerbated and developed drop in hemoglobin. urgent ct scan showed a bleeding gastric tumor. urgent laparotomy identified a bleeding gastric lesion at greater curvature. partial gastrectomy done with abutting mesocolon resection. surgical specimen pathology showed gastric intramural hematoma that was considered spontaneous.

Eligibility criteria:
inclusion criteria: * any patient presenting with gastric bleeding tumors exclusion criteria: * patients on anticoagulants and patient with gastric medical history
the relationship between pelvic floor muscle function and hip pain among women

Conditions: Incontinence Stress; Incontinence; Hip Pain Chronic

Summary: this study examines the relationship between pelvic floor muscle (pfm) function and self-perception of pfm contraction with hip pain, their severity, and hip muscle strength. in addition, it will examines the association between pfm function, and anxiety.

this cross-sectional study will include women with symptoms of hip-related pain persisting \> three months(research group), and women without hip pain (control group). a single session will include various assessments as follows: abdominal ultrasound examination to evaluate pfm function and endurance, in addition, each participant will evaluate her ability to perform correct contraction of pfm, hand-held dynamometer testing for hip rotator muscle strength, the international consultation on incontinence questionnaire (iciq) for evaluating symptoms and impact of urinary incontinence, the international hip outcome tool 12 for assessing hip function and pain, the hospital anxiety \& depression scale (hads), and a functional performance task involving the hip muscles - a single-leg squat.

Eligibility criteria:
inclusion criteria for research group: * complaints of hip related pain, * visual analog scale (vas) \>3 for three months, * with one or more of the symptoms relevant to the syndrome - (1) hip or groin pain produced by a certain movement or position, stiffness and limitation of movement or clicks from the hip joint, (2) examination a positive fadir performed by the researcher before conducting the study exclusion criteria: * the presence of additional diagnoses of the slipped capital femoral epiphysis, * perthes disease, * avascular necrosis, and osteoarthritis-calve-legg, * neurological or metabolism, * surgery/fracture in the hip joint of which the woman complains, * pregnancy or childbirth in the last year, * treatment of the pelvic floor in the last year. control group - health women without any pain or symptoms in the spine and lower extremities

Keywords: pelvic floor women health ultrasound incontinence
incidence of brue among the hospitalized infants: towards a change in medical practices?

Conditions: Brief Resolved Unexplained Events (BRUE)

Summary: the malaise of the infant represents a polymorphic pathology in its clinical presentation. due to the young age of the patients concerned and the parental anxiety generated, hospital management is necessary, for clinical and paraclinical evaluation and monitoring. the practice of complementary examinations is guided by personal and family history, and the precise description of the discomfort as well as clinical examination of the child and assessment of his vital parameters. however, in view of the particular terrain represented by infants under one year of age, a number of tests are carried out systematically, and therefore empirically, because they are not guided by the clinic. these various tests can be invasive, anxiety-provoking for parents and generate a significant additional cost during hospital management. an evaluation of the indication and interest of these tests is necessary in order to propose a homogeneous clinical and paraclinical management of the discomfort of the infant, in particular of discomforts of type brue (brief resolved unexplained events), as described in the 2016 american academy of pediatrics (aap) recommendations.


Eligibility criteria:
inclusion criteria: * infant less than one year old * admitted to the paediatric emergencies of the chru of nancy between 11/01/2019 and 04/30/2020 for discomfort exclusion criteria: * child over one year old * reasons for consultation in paediatric emergencies other than "malaise";
psychological status and self-care in chronic cardiovascular disease

Conditions: Anxiety; Depression; Emotional Stress; Quality of Life; Self-care; Chronic Cardiovascular Disease

Summary: this is an observational study aimed at exploring the relationship between psychological status and self-care in patients with chronic cardiovascular disease

400 patients with chronic cardiovascular disease were enrolled in this observational study aiming at exploring the relationship between their psychological status (anxiety, depression, emotional distress and quality of life) and their self-care.

Eligibility criteria:
inclusion criteria: * being aged \> 18 years old and \> 85 years old * being diagnosed with a chronic cardiovascular disease * being able and willing to sign the informed consent form exclusion criteria: * having a cognitive dysfunction or psychotic disorder signaled in the clinical documentation * not speaking italian
perioperative ischemia versus perioperative bleeding during non-cardiac surgery in cardiac patients

Conditions: Surgical Procedure, Non-cardiac; Cardiovascular Disease Patients; Perioperative Period

Summary: the aim of the study is to analyze the present use of antithrombotic therapy on a large cohort of consecutive cardiacs undergoing non-cardiac surgery. if even and for how long the medication was discontinued, if any other antithrombotic therapy was used in the perioperative period and prevalence of perioperative complications - especially ischemic or bleeding. these complications will be correlated with the pattern of antithrombotic therapy administration. working hypothesis is to obtain a large database of unselected cohort of consecutive patients for mapping of this practically important, but in the evidence-based medicine, still neglected problem.

this project will closely describe (prospective registry) the present situation (anti-thrombotic medication, prevalence of bleeding and ischemic complication) in a large consecutive cohort of non-selected cardiac patients, who are undergoing non-cardiac surgery. patients have to meet all three inclusion criteria: (1) any kind of non-cardiac surgery (acute or elective) performed under general or neuraxial anaesthesia in four surgical departments - general surgery, orthopedics-trauma, urology and neurosurgery. (2) history of cardiac disease with risk of arterial, intracardiac or vein thrombosis or embolism. (3) signed informed consent. all operated patients who meet the inclusion criteria will get enrolled, i.e. all consecutive cardiacs, who signed informed consent. baseline clinical indicators, chronic and perioperative medication, ecg, laboratory tests and all complications (especially ischemic and bleeding) will be registered. participants will be followed for the duration of hospital stay, an expected average of 10 days.

Eligibility criteria:
inclusion criteria: * any kind of non-cardiac surgery (acute or elective) performed under general or neuraxial anaesthesia in four surgical departments - general surgery, orthopedics-trauma, urology and neurosurgery. * history of cardiovascular disease with risk of arterial, intracardiac or vein thrombosis or embolism. (3) signed informed consent. exclusion criteria: * there are no exclusion criteria

Keywords: noncardiac surgery; perioperative ischemic complications; perioperative bleeding complications; antithrombotic therapy; coronary artery disease; stent thrombosis; perioperative infarction.
work-related respiratory symptoms in champagne vineyard workers

Conditions: Respiratory Symptoms

Summary: work related asthma and rhinitis are frequent diseases with a significant morbidity and a social and economic impact. farmers are highly exposed to various inhaled agents such as organic or inorganic dust, endotoxin, micro-organisms, pollen, mites, moulds, animal danders and pesticides, inducing rhinitis, asthma, chronic bronchitis, hypersensitivity pneumonitis and organic dust toxic syndrome. work related respiratory symptoms are frequent in crop farmers. allergic rhinitis and respiratory symptoms in fruit farmers are mainly related to pollen allergy, especially gramineae pollen. they can also be related to the use of pesticides or exposure to mites .

aim of the study were : to determine the prevalence of work related respiratory symptoms in workers of champagne vineyard in france to analyze the relationships between respiratory symptoms, occupational exposure and sensitization profile in workers of champagne vineyard in france

Eligibility criteria:
inclusion criteria: * workers of champagne vineyard * aged \> 18 years
efficacy of a prebiotic galactooligosaccharide to reduce metabolic syndrome risk factors in overweight adults

Conditions: Metabolic Syndrome X

Summary: the traditional risk factors for obesity are inappropriate diet, lack of exercise and genetic factors. however, recent observations have involved gut microbiota profiles as having an additional influence. in this case, there exists the possibility to modulate this through diet. research has shown that the gut microbiota of both obese humans and mouse models of obesity is altered towards less beneficial one compared to lean counterparts. this raises the possibility of modulating the gut microbiota as a novel strategy in tackling the epidemic of obesity and diabetes sweeping the developed world. in addition, a more direct effect of high-fat induced disruption of the intestinal microbiota has also been seen with a murine model. elevated circulating levels of lipopolysaccharide (lps) a major building block and antigen of gram-negative bacteria, was shown to generate a low grade chronic inflammation, termed metabolic endotoxemia, which then onsets insulin resistance. high-fat diets were shown to disrupt the gram-negative intestinal populations of these animals, liberating lps. the effects of prebiotics on the microbiota or metabolic syndrome (combination of disorders that increase the risk of developing cardiovascular disease and diabetes) in overweight adults have not been investigated thus far. the investigators therefore propose to investigate the effect of galactooligosaccharide (gos) on the faecal microbiota and metabolic syndrome risk factors in overweight adults in a double-blind, randomised, placebo controlled, cross-over trial.


Eligibility criteria:
inclusion criteria: * 18-65y * bmi \>25 kg/m2 exclusion criteria: * suffered from a myocardial infarction/stroke or cancer in the past 12 months * diabetic or suffering from endocrine disorders * suffer from renal or bowel disease/gut disorder or have a history of cholestatic jaundice or pancreatitis * requirements to take long-term medication for hyperlipidaemia, hypertension, inflammation or hypercoagulation * history of alcohol or drug abuse * planning or on a weight reducing regime * taking antioxidant (or phytochemical), probiotic or prebiotics supplements * pregnant or lactating women or those planning pregnancy in the next 6 months or of child-bearing age who are not using contraception * use of antibiotics within the previous 1 month * anemic * smoker
bioequivalency study of levetiracetam 1g tablets under fed conditions

Conditions: Seizures

Summary: the objective of this study was to prove the bioequivalence of levetiracetam 1000 mg tablets under fed conditions


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. treatment with known enzyme altering drugs. history of allergic or adverse response to levetiracetam or any comparable or similar product.
impact of telehealth care

Conditions: Telehealth Services; Telehealth

Summary: heart failure is associated with high incidence and mortality rates, limited physical activity, decreased quality of life, and increased healthcare expenses. implementing a telehealth care (tc) hf program could address these challenges while improving patient outcomes.

telemonitoring for heart failure patients reduces all-cause and cardiovascular mortality by enabling early intervention during clinical deterioration, improving outcomes even for those recently discharged. moreover, a reduction in the percentage of days lost due to unplanned cardiovascular hospital admissions is evident. furthermore, the rapid expansion of telehealth care and telemedicine services during the covid-19 pandemic optimized the management and care quality of heart failure patients through telemonitoring .

Eligibility criteria:
inclusion criteria: * inpatients diagnosed with heart failure were enrolled, with patients automatically selected daily by the electronic medical record system. a list of ward visits was obtained based on the first three digits of the international classification of diseases 10th edition diagnosis codes; the icd-10 code i50 was applied for selection. exclusion criteria: * other diagnosis

Keywords: telehealth, heart failure, rehospitalization, mortality
clopidogrel prevention of early arteriovenous (av) fistula thrombosis

Conditions: Kidney Failure; Hemodialysis Fistula Thrombosis

Summary: the objective of the study is to determine whether clopidogrel reduces the early failure rate of native av fistulae. this study was originally registered as nct00067119 which included two protocols, this one and the graft study)


Eligibility criteria:
fistula study protocol inclusion criteria: * age 18-21 depending on state regulations * life expectancy of at least six months * chronic renal failure with anticipated start of hemodialysis within six months of enrollment, or current dialysis dependence * planned creation of native upper extremity av fistula * the patient is not on aspirin, or the patient is on aspirin but has not had a myocardial infarction or a cerebrovascular accident within the past 12 months. * the patient is expected to stay at a participating dialysis facility for at least 6 months. * the patient's physician(s) will allow the patient to participate. * ability to give informed consent. exclusion criteria: * women must not be pregnant, breastfeeding, or plan to be pregnant during the course of the study. * the presence of ongoing bleeding. * the presence of a known bleeding disorder (e.g., hemophilia or von willebrand's disease). * recent bleeding episode requiring transfusion within 12 weeks of entry. * the presence of acute ulcer disease. acute ulcer disease is defined as a new diagnosis of peptic disease including esophagitis, gastritis, or ulcer or the initiation of treatment with proton pump inhibitors, h2 blockers or therapy for helicobacter pylori within three months prior to obtaining consent. * a condition which prohibits discontinuation of anticoagulant drugs, aspirin, or nonsteroidal anti-inflammatory drugs during the six week study drug administration period. use of heparin during dialysis is allowed. * required use of oral or intravenous glucocorticoids at a dose greater than the equivalent of prednisone 15 mg per day during the six week study drug administration period. * current unstable angina. * required use of clopidogrel. * known hypersensitivity to clopidogrel. * medical considerations making anti-platelet therapy dangerous. * current uncontrolled hypertension with systolic blood pressure in excess of 200 mm hg or diastolic blood pressure in excess of 115 mm hg at the time of enrollment. * baseline platelet count less than 75,000/mm3. * known advanced liver disease with decompensated cirrhosis, jaundice, ascites or bleeding varices. * current problem with substance abuse. * concurrent participation in another medical intervention trial. * anticipated non-compliance with medical care based on physician judgment. * patient refusal.

Keywords: access blood flow monitoring clinical trial vascular access fistula failure hemodialysis vascular access
parathyroid reimplantation in forearm subcutaneous tissue during thyroidectomy: a simple way to avoid ipoparathyroidism and evaluate graft function

Conditions: Thyroid Goiter; Thyroid Carcinoma; Multinodular Goiter; Graves Diseases

Summary: the purpose of this study is to evaluate safety and effectiveness of normal parathyroid tissue reimplantation in forearm subcutaneous tissue in case of accidental removal of parathyroid gland during thyroid surgery.


Eligibility criteria:
inclusion criteria: * patients affected by benign thyroid disease undergoing thyroidectomy
obesity queue database

Conditions: Obesity

Summary: to establish an obesity specific disease cohort database and form a special disease cohort, so as to provide guarantee for carrying out high-quality real-world clinical research and clinical research.


Eligibility criteria:
inclusion criteria: * patients aged 18-75 years with simple obesity. simple obesity diagnosis criteria: meet one of the following conditions 1. bmi≥25 kg/m2 2. waist circumference for male/female ≥90/80 cm 3. waist-to-hip ratio: 0.9 (male); 0.85 (female) exclusion criteria: * patients aged 18-75 years with simple obesity. simple obesity diagnosis criteria: meet one of the following conditions 1. bmi≥25 kg/m2 2. waist circumference for male/female ≥90/80 cm 3. waist-to-hip ratio: 0.9 (male); 0.85 (female)
effects of combined physical-cognitive training on cognitive function in mci

Conditions: Mild Cognitive Impairment

Summary: the present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral bdnf level and mitochondrial function of individuals with mci. it is hypothesized that: 1) the combined physical-cognitive training program will be superior to the physical and cognitive training program alone; and 2) the degree of cognitive improvement will be positively correlated with the improvement of plasma bdnf and mitochondrial function.

recent research suggests that the benefits of combined physical-cognitive training may be greater than either physical or cognitive training alone. nevertheless, this synergistic effect has been demonstrated mainly in cognitively intact older adults. studies examining the effects of combined physical-cognitive training in older adults with mci are scarce and show mixed results. moreover, few studies have determined the effects of the combined training on peripheral brain-derived neurotrophic factor (bdnf) and mitochondrial function. thus, the present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral bdnf level and mitochondrial function of individuals with mci. the present study will provide insight into the interplay among the training program, peripheral bdnf concentration, mitochondrial function, and cognitive function. importantly, the findings will have clinical implication regarding the training program that is feasible and effective in improving cognitive function of older adults with mci which ultimately will have great impact on public health as this population is at high risk of progression to ad.

Eligibility criteria:
inclusion criteria: * meet criteria for mncd (mild neurocognitive disorders), previously known as mci, based on the recent dsm-v (diagnostic statistical manual-v) criteria * comprehend instructions and willing to participate * able to comply with the study schedule and procedures * not taking any medications for their cognition and not planning to start medications during the study trial exclusion criteria: * presence of medical conditions that would be unsafe to exercise * diagnosed with other neurological conditions (e.g. parkinson's disease, stroke, multiple sclerosis, ad) that affect cognition and mobility * presence of depressive symptoms * presence of acute or/and chronic disease that could not be controlled (e.g. arthritis, asthma, hypertension, diabetes mellitus, coronary artery disease) * exercise regularly (at least 30 min/day, 3 days/week)

Keywords: mild cognitive impairment combined physical-cognitive training bdnf mitochondrial function cognitive function
s0010 506u78 in treating patients with recurrent or refractory acute lymphocytic leukemia

Conditions: Leukemia

Summary: rationale: drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. purpose: phase ii trial to study the effectiveness of 506u78 in treating patients who have recurrent or refractory acute lymphocytic leukemia.

objectives: * assess the complete remission rate in patients with recurrent or refractory non-t-cell acute lymphocytic leukemia when treated with 506u78. * determine the frequency and severity of toxic effects of this drug in these patients. outline: this is a multicenter study. patients receive 506u78 iv over 2 hours on days 1, 3, and 5. treatment continues every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. patients are followed every month for 6 months, every 3 months for 1 year, and then every 6 months for 3.5 years. projected accrual: a total of 20-35 patients will be accrued for this study within 18 months.

Eligibility criteria:
disease characteristics: * diagnosis of acute lymphocytic leukemia (all) * fab class l1-l2 * non-t-cell all (lymphocytic immunophenotype markers cd19+, cd5-, and cd7- in peripheral blood, bone marrow, or in at least 1 extramedullary disease site) * coexpression of myeloid antigens cd13 or cd33 allowed * histologically confirmed extramedullary disease in the absence of bone marrow or blood involvement allowed * cd3 and myeloperoxidase marker negative * meeting 1 of the following criteria for recurrent/refractory disease: * refractory to standard induction regimen including at least vincristine and prednisone * recurrence after response after prior induction therapy * recurrence and failure on subsequent treatment * no cns involvement * must be registered on swog-s9910 and swog-9007 patient characteristics: age: * 16 and over performance status: * zubrod 0-3 life expectancy: * not specified hematopoietic: * not specified hepatic: * bilirubin no greater than 1.5 times upper limit of normal (uln) * sgot or sgpt no greater than 3 times uln renal: * creatinine no greater than 2 times uln other: * not pregnant or nursing * fertile patients must use effective contraception * no grade 2 or greater neuropathy * no other prior malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or any other adequately treated stage i or ii cancer in complete remission prior concurrent therapy: biologic therapy * not specified chemotherapy * see disease characteristics endocrine therapy * not specified radiotherapy * not specified surgery * not specified

Keywords: recurrent adult acute lymphoblastic leukemia l1 adult acute lymphoblastic leukemia l2 adult acute lymphoblastic leukemia b-cell adult acute lymphoblastic leukemia non-t, non-b adult acute lymphoblastic leukemia