Kornimate/medical-research-clean huggingface dataset:
tolerability, safety and efficacy of sad448 in subjects with ocular hypertension

Conditions: Ocular Hypertension

Summary: this study will evaluate the tolerability and safety of sad448 and explore the compound's effect on intraocular pressure in subjects with ocular hypertension.


Eligibility criteria:
key inclusion criteria: * males and females, 18 - 65 years of age, with ocular hypertension * females must be post-menopausal or surgically sterile key exclusion criteria: * diagnosis of glaucoma in either eye * a history of or current eye conditions or medical problems that would prohibit the use of an investigational drug

Keywords: ocular hypertension sad448
microwave ablation and surgical resection for micropapillary thyroid carcinoma

Conditions: Papillary Thyroid Carcinoma

Summary: the study aimed to compare the efficacy and safety of papillary thyroid microcarcinoma (ptmc) treated with microwave ablation(mwa) and surgery resection (sr), and to explore the tumor characteristics suitable for each treatment methods (such as with and without capsular invasion). the investigators organized 18 hospitals to participate in this multicenter study. patients meeting following indications will be included in this study: 1. biopsy pathology proved ptmc, but not high-risk subtype; 2. solitary mptc, without us-detected gross extrathyroid extension; 3. no evidence of metastasis; 4 willing to participate in this study and perform regular follow-up. patients themselves decide to receive mwa or sr for mptc after medical consultation. baseline characteristic including age, gender, thyroid function et al. will be collected. the treatment protocols of mwa and sr were according to the chinese and international guidelines. the primary outcomes were the disease progression, including local tumor recurrence, lymph node metastasis, and distant metastasis. the secondary outcomes include thyroid function, complication rate, blood loss et al. investigators will follow up enrolled patients and collect and upload data according to the trial. treatment outcomes of tumor with and without us-detected capsular invasion was analyzes as subgroups.

the treatment protocols of mwa and sr were according to the chinese and international guidelines. mwa need to ablate all tumors including at least 2mm safe margin except for tumors adjacent to thyroid capsule. sr basic protocol is lobectomy + central lymph node dissection. all patients need to receive levothyroxine therapy to keep tsh lower than 0.5 mu/l. patients in both groups underwent regular medical imaging and laboratory tests 1 month, 3-month, 6-month, 12-month, 18-month, 24-month and 36-month after treatment.

Eligibility criteria:
inclusion criteria: * biopsy pathology proved micropapillary thyroid carcinoma(mptc), but not high-risk subtype * solitary mptc, without us-detected gross extrathyroid extension * no evidence of metastasis * willing to participate in this study and perform regular follow-up exclusion criteria: * severe blood coagulation dysfunction (platelet count \ 1.5) * acute or severe chronic renal failure, pulmonary insufficiency or heart dysfunction * poor control of blood pressure(systolic pressure≥150mmhg or diastolic pressure≥95mmhg) * poor control of blood glucose(fasting glucose\>10mmol/l) * the opposite vocal cords dysfunction * diagnosed with other malignant tumors * pregnant and lactating women * other conditions that investigator believe are not appropriate to be enrolled

Keywords: papillary thyroid carcinoma microwave ablation surgical resection
robotic-assisted percutaneous coronary intervention

Conditions: Coronary Artery Disease

Summary: percutaneous coronary intervention is a safe procedure. however, its execution is manual, fully operator-dependent. the procedure is also associated with radiation exposure to patients and physicians. this study will evaluate the robotic assisted percutaneous coronary intervention as an alternative to manual operation.


Eligibility criteria:
inclusion criteria: 1. age\> = 18 years; 2. symptomatic ischemic heart disease and / or objective evidence of myocardial ischemia with one or more target lesions; 3. elective for percutaneous procedure (i.e. performed in a non-urgent context) 4. the target lesion (s) must be obstructive, with stenosis diameter \> 50% (visual analysis); 5. the interventional planning of all target lesions should include robotic manipulation in at least one treatment, as judged by the operator; 6. acceptable candidate for myocardial revascularization surgery. exclusion criteria: 1. st-segment elevation myocardial infarction in the last 48 hours before the index procedure; 2. ejection fraction \<30%; 3. impaired renal function (creatinine\> 2.0 mg / dl) or calculated creatinine clearance \<30 ml / min; 4. platelet count \ 700,000 cells / mm 3; 5. total leucocytes count \<3,000 cells / mm 3; 6. suspected or documented active liver disease (including laboratory evidence of hepatitis); 7. heart transplant recipient; 8. allergies known to aspirin, clopidogrel, ticlopidine, ticagrelor, prasugrel, heparin, antiproliferative agents of the limus family, or stainless steel; 9. patient with a life expectancy of less than 1 month; 10. any significant medical condition that in the opinion of the investigator may interfere with the patient's ideal participation in this study; 11. participation in other research in the last 12 months, unless there may be direct benefit to the research subject; 12. any invasive cardiac or non-cardiac treatment scheduled within the first month after the index procedure. angiographic exclusion criteria 1. need for non-robotic (i.e. manual) treatment of another injury in the index procedure or in the first month; 2. target lesion not accessible by robotic treatment, according to the judgment of the operator; 3. unprotected coronary artery trunk lesion (stenosis\> 50%); 4. angiographic thrombus; 5. target lesion in surgical graft; 6. total occlusion (timi 0 or 1 anterograde flow)
risk factors and results of emergency ventral hernia repair

Conditions: Ventral Hernia

Summary: the aim of present study was to evaluate the clinical course after emergency ventral hernia repair in terms of 30-day-readmission, -reoperation and -mortality and to identify risk factors for emergency repair.

all incisional, umbilical and epigastric hernias registered in the danish ventral hernia database

Eligibility criteria:
inclusion criteria: * all incisional, umblilical and epigastric hernia repiars
study of ro6807952 in patients with diabetes mellitus type 2

Conditions: Diabetes Mellitus Type 2

Summary: this randomized, double-blind, placebo-controlled, multi-center study will evaluate the efficacy and safety of ro6807952 in patients with diabetes mellitus type 2 inadequately controlled with metformin alone. patients will be randomized to receive doses of ro6807952, placebo, or liraglutide. the anticipated time on study treatment is 12 weeks.


Eligibility criteria:
inclusion criteria: * adult patients \>/= 18 and \</=70 years of age * diagnosis of diabetes mellitus, type 2 for at least 3 months * treated with a stable dose of metformin * hemoglobin a1c \>/=7.0% and \</=10.5% at screening * fasting plasma glucose \</=240 mg/dl at screening * body mass index \>/=27 kg/m2 and \</=42 kg/m2 at screening * willing and able to maintain existing diet and exercise habits throughout the study * c-peptide \>1.5 ng/ml at screening exclusion criteria: * history of significant liver or kidney disease * history of uncontrolled hypertension * history of significant cardiovascular disease * history of significant diabetic complications * history of significant gastrointestinal conditions * history of weight loss surgery or procedures involving the gastrointestinal tract * history of chronic or acute pancreatitis
intraoperative ultrasound in bowel deep endometriosis

Conditions: Deep Infiltrating Endometriosis With or Without Bowel Involvement

Summary: this study investigates the use of intraoperative transvaginal (iotvus) and/or endorectal ultrasound (ioerus) in the surgical treatment of bowel deep infiltrating endometriosis (die).

bowel die is a severe form of endometriosis that often infiltrates the rectum and the sigmoid colon, requiring precise surgical techniques to achieve complete excision while minimizing unnecessary resections of healthy tissues and organs. current preoperative imaging techniques, such as transvaginal ultrasound and magnetic resonance imaging, are often limited in their ability to assess lesion depth and extent in cases of severe pelvic anatomical distortion. intraoperative ultrasound offers a real-time evaluation after rectal mobilization, allowing for a more accurate assessment of lesion location, depth, and bowel wall infiltration. the primary objectives are to evaluate the feasibility and accuracy of intraoperative ultrasound in detecting rectal and rsj die nodules and to guide surgical decision-making. secondary objectives include determining the impact of these techniques on surgical outcomes, postoperative pain management, and quality of life. the goal is to enhance surgical decision-making by accurately assessing lesion depth and location, potentially reducing unnecessary colorectal resections or avoiding inadvertent retention of endometrial nodules. participants will complete health and pain questionnaires preoperatively and at 3, 6, and 12 months postoperatively, evaluating dysmenorrhea, dyspareunia, dyschezia, and quality of life using validated tools. the study will also document intraoperative findings, surgical decisions, complications, and postoperative outcomes. by combining iotvus and ioerus with existing surgical approaches, this study seeks to establish these techniques as standard tools for improving surgical precision in bowel die cases. results could provide valuable insights for tailoring interventions to patient-specific disease presentations, enhancing long-term management strategies.

Eligibility criteria:
inclusion criteria: * preoperative sonographic and/or mri findings suggestive of bowel die (uterosacral ligaments, posterior vaginal wall, parametrium, retrocervical area, rectovaginal septum, rectum, and/or sigmoid colon). * scheduled for surgical treatment (laparoscopy or robot-assisted laparoscopy). * planned postoperative follow-up for at least 12 months. * written informed consent provided before surgery. exclusion criteria: * planned surgery for diagnostic purposes only. * pregnancy at the time of enrollment. * poor understanding of spanish or english.

Keywords: endometriosis intraoperative ultrasound ultrasound surgery minimally invasive surgery
staphylococcus aureus carriers students nursing oxacillin resistant

Conditions: Staphylococcal Infections

Summary: the staphylococcus aureus is an important pathogen bacteria actuating as an agent of a wide variety of infections, such as the superficials to the disseminates ones, its commonly find into hospitals ambient, assailing mainly immunosupress patients. around 30% to 50% of people carries this agent in their nasal bone as part of their normal flora, occuring larger in hospitals workers. the s. aureus is also known for its high capacity of developing resistance to various antibiotic. facing these considerations, the importance of nursing precaution and the infections control inside hospitals ambient, the purpose of this present study aimed to verify the rates of carriers of s. aureus in nursing students and the connection with the hospitals time involvement during graduation in the faculty de medicine de botucatu - unesp, embracing the 4 years of graduation college.


Eligibility criteria:
inclusion criteria: * students nursing exclusion criteria: * students nursing with infection

Keywords: staphylococcus aureus carriers students nursing
comparing the rate of insufficient cells for diagnosis between surepath® and conventional smear in women after radiation therapy for cervical cancer

Conditions: Cervical Cancer

Summary: background/purpose: this is a large scale, multicenter randomized clinical trial to assess the feasibility of using surepath® in cervical cancer patients after radiation therapy by comparing the incidence of unsatisfactory smear and the accuracy of detecting cervicovaginal lesions between the surepath® and the conventional smear. patients and methods: the investigators will invite all women who had received radiotherapy for cervical cancer in the investigators outpatient clinics. all enrolled cases will ask to receive randomly the surepath® or the conventional smear. expected results: the investigators will get the incidence of unsatisfactory smear and the accuracy of detecting cervicovaginal lesions between the surepath® and the conventional smear in patients who underwent radiotherapy.

adequate specimen (specimen adequacy) is cervical or vaginal cytology single most important quality factors. 2001 pap bethesda system classification maintain its previous version, the pap specimen is divided into satisfactory assessment and unsatisfactory evaluation two kinds; meet "satisfactory assessments "specimen standard, conventional pap (conventional smear) requires at least 8,000-12,000-readable squamous cells, and liquid-based pap (liquid-based smear) you need at least 5,000-readable squamous cell . for squamous cell samples were determined to be adequate, yet to record their specimens have intrauterine neck or squamous transitional zone (transformation zone) border zone cells exist; quality indicators "cell interpretation in part by inflammation or blood masking noise "of the specimen, if it can not be sentenced to 50-75% of epithelial cells can still be classified as read" satisfied "with the specimen, while more than 75% of the epithelial cells are obscured interference specimen is classified in the" unsatisfactory "specimen.

Eligibility criteria:
inclusion criteria: 1. all women who had received radiotherapy for cervical cancer in our outpatient clinics. 2. prior to joining test subjects for 90 days or more earlier had received a complete pelvic radiation therapy, including treatment of the cervix or vagina. 3. subjects with radiation therapy (including combined chemical and radiation therapy or postoperative adjuvant \[chemical\] radiation therapy) for their first treatment. exclusion criteria: 1. recurrence of cervical cancer 2. hormone treatment within 90 days 3. vaginal vault or cervix topical treatment within 90 days. 4. subjects had or now have other malignancies
donafenib as adjuvant therapy following ablation for recurrent hcc

Conditions: Hepatocellular Carcinoma; Microwave Ablation; Donafenib; Recurrent Tumor

Summary: this study intends to evaluate the efficacy and safety of low-dose adjuvant donafenib after thermal ablation for early recurrent hcc within milan criteria.

thermal ablation is available as the major curative treatments for early-stage recurrent hcc. donafenib was inferior to sorafenib in overall survival in untreated advanced hepatocellular carcinoma. no study has evaluated low-dose donafenib as adjuvant therapy after thermal ablation. there needs further investigation to explore the efficacy and safety of the combination treatment. thus, the investigators carried out this prospective, randomized, open-label, phase ii trial study to find out it.

Eligibility criteria:
inclusion criteria: 1. were aged 18-75 years; 2. had recurrent hcc (rhcc) diagnosed by imaging studies, the first or the second rhcc; 3. rhcc met the milan criteria, namely single rhcc lesion less than 5 cm in diameter or no more than 3 tumors (each ≤3 cm in diameter); 4. the early rhcc (recurrent time \<1 year) 5. patients were unwilling to undergo repeat hepatectomy or liver transplantation; 6. had well-preserved liver function, i.e., child-pugh class a or b, and prolonged prothrombin time≤5 s; 7. patients had an eastern cooperative oncology group performance status score ≤1. 8. ability to understand the protocol and to agree to and sign a written informed consent document. exclusion criteria: 1. were under 18 years or over 75 years of age; 2. primary hcc; 3. recurrent hcc beyond milan criteria; 4. rhcc with metastasis or macrovascular tumor thrombus
the effect of competition season on physical characteristic and shoulder periarticular structures in swimmers

Conditions: Image; Athletic Injuries; Upper Extremity

Summary: the aim of this study is to investigate the effect of a competition season on shoulder periarticular structures, muscle strength, muscle endurance, joint range of motion and upper extremity performance in young swimmers.

after being informed about the study, all swimmers giving written informed consent will undergo a 1- week screening period to determine eligibility for study entry. swimmers who meet the eligibility requirements will be evaluated 3 times: pre-season, mid-season, and post-season.

Eligibility criteria:
inclusion criteria: * to be between the ages of 10-15 * at least 6 hours of swimming training per week, * individuals do not have cooperation and communication problems, * individuals volunteer to participate in the study. exclusion criteria: * previous upper extremity surgery, * experienced upper extremity pain at least 2 times in the past, * not attending training regularly for any reason.

Keywords: ultrasonography upper extremity subacromial space young swimmers muscle strength range of motion
non obstructive versus obstructive coronary artery disease

Conditions: Non-Obstructive Coronary Artery Disease

Summary: the goal of this observational study is to study the non obstructive type of ischemic heart disease by identifying unique clinical features , frequency and age group .in patient admitted in coronary care unit , suffered from angina or heart attack. . the main question\[s\] it aims to answer are: * how it different from classical type of ischemic heart disease ( obstructive coronary artery disease) * what is frequency and age prevalence of these patient participants evaluated by history , clinical examination, serum troponin and coronary angiography.


Eligibility criteria:
inclusion criteria: * patients diagnosed with ihd ( mi, unstable angina ,chronic stable angina) * \>18 years of age * patients undergoing cag for emergency or elective situations. exclusion criteria: * patients who were hemodynamically unstable. * patients with incomplete data * patients with clinical features of pericarditis or others of non cardiac origin chest pain .
booster as an adjunct to internet-based cognitive behavior therapy (cbt)

Conditions: Obsessive-compulsive Disorder

Summary: in this trial, we test if adding an internet-based booster program to regular internet-based cognitive behavior therapy (icbt) is effective for patients with obsessive-compulsive disorder (ocd).

written consent form. completing icbt in our previous study: please see nct01347099 for more details.

Eligibility criteria:
inclusion criteria: * signed consent * previously enrolled in our randomized controlled trial testing icbt for ocd: nct01347099 exclusion criteria: * suicidal ideation that could jeopardize participation

Keywords: booster program internet cbt study the specific effects of adding a booster program
orthostatic tolerance in mamma cancer patients after anaesthesia

Conditions: Breast Cancer

Summary: the investigators want to investigate the effect of anaesthesia, on the ability to maintain upright posture immediately after surgery in mamma cancer patients. the investigators hypothesis is, that a standard anaesthesia does not effect the ability to maintain upright posture right after surgery.

it is known, that patients undergoing major surgery have problems maintaining upright posture after major surgery. this can be due to fall in bloodpressure, with symptoms like dizziness, nausea/vomiting and fainting. with this investigation, we want to prove that anaesthesia is not the decisive factor, in patients ability to maintain upright posture after surgery.

Eligibility criteria:
inclusion criteria: * patients having performed elective breast surgery * age between 18 and 70 years * patients who have given written consent to participate in the project after haven completely understood the contents and limitations of the protocol exclusion criteria: * patients who do not understand or speak danish * patients who have not signed the informed consent or the written authority pre-medication, except 1g paracetamol * asa \> ii * pregnant or breastfeeding * known to have renal disease * known to have psychiatric disorder (not considering the use of ssri antidepressive) * need for crash induction or prone position * oesophageal varicoses * necrosis or cancer in: mouth, pharynx, larynx or oesophagus * coarctation or aneurism in the proximal aorta * severe bleeding disease

Keywords: mammae cancer patients
vitamin d metabolism in chronic kidney disease patients

Conditions: Vitamin D Metabolism is in Chronic Kidney Disease

Summary: to determine whether or not chronic kidney disease (ckd), stages iii-v and esrd , is associated with altered vitamin d metabolism related to fibroblast growth factor-23 (fgf-23) stimulation of cyp24 and whether they have resistance to elevations of 25 hydroxyvitamin d (25(oh)d3) after cholecalciferol supplementation. to determine if such resistance is related to enhanced catabolism of (25(oh)related to elevated levels of fgf-23.

1. patients in the memphis va medical center with documented vitamin d deficiency, determined by measurements of 25(oh)d3, were recruited for this study. 25(oh)d3 measurements are commonly obtained during routine clinical care in both primary care and nephrology clinics. patient with a wide range of kidney function, ranging from normal estimated glomerular filtration rate (e gfr) to patients with stage iii and v (ckd) (estimated gfr \<60 ml/min) were recruited treated with weekly oral administration of 10,000 iu of cholecalciferol for a total of 8 weeks in order to correct the vitamin d deficiency. 2. data collected: baseline characteristics including demographics, laboratory data obtained at primary care clinic visits, clinical data from the vamc medical record and medications were obtained at the time of inclusion into the study. serum concentrations of fgf23, 25(oh)d, 1,25 dihydroxyvitamin d(1,25 (oh)₂d), 24,25 dihydroxyvitamin d(24,25(oh)₂d) ,intact parathyroid hormone (pth), calcium, phosphorous and creatinine and urinary concentrations of calcium, phosphate and creatinine from 24 hr urine collections were obtained at the time of inclusion into the study and after 8 weeks of weekly cholecalciferol therapy. serum and buffy coats which were recollected from dialysis patient's who agreed to participate, were used to measure mrna levels of fgf-23, cpy27b1 and cyp 24 expression. 3. methods utilized in analyzing and interpreting the data descriptive statistics will be performed to compare serum and urinary measurements before and after cholecalciferol therapy. associations between estimated glomerular filtration rate and levels of vitamin d metabolites and fgf23, before and after treatment, will also be evaluated. the mrna expression of fgf-23, cpy27b1 and cyp 24 will be measured in a subset of dialysis patients who completed the treatment course and agreed to provide the additional samples. 4. duration of the project: 1 year.

Eligibility criteria:
inclusion criteria: * age 18-85 years; ckd stage iii or v; serum 25(oh)d level ≤ 30ng/ml, and serum pth levels \> 70 pg/ml within the last 6 months, informed consent. exclusion criteria: * a history of liver disease, sarcoidosis, intestinal malabsorption; * requirement of dialysis during the study; serum calcium level \>10.5 mg/dl, * calcium-phosphorus product \> 70, or * calcimimetics, or * phosphorus binders; or * medications that could affect vitamin d metabolism or * history of parathyroidectomy.

Keywords: fgf-23, ckd, cyp24, 24,25(oh)2d, vitamin d metabolism