Kornimate/medical-research-clean huggingface dataset:
longitudinal use of protective behavioral strategies

Conditions: Alcohol Use, Unspecified

Summary: this study tested a deviance regulation theory intervention in a sample of university freshman. the aims were to (a) increase use of protective behavioral strategies, (b) decrease alcohol use, and (c) decrease alcohol-related consequences.

college student freshmen were invited to participate in a study on the use of alcohol protective behavioral strategies. they were randomly assigned to receive a positive message about individuals that used protective strategies, a negative message about individuals that did not use protective strategies, or an assessment control. they were then followed for the next 12 months. assessments were completed at weeks 0, 1, 2, 3, 4, 5, 12, 26, and 52.

Eligibility criteria:
inclusion criteria: * college freshman at ucf * endorse alcohol consumption in the past two weeks exclusion criteria: * severe mental illness * under 18 years of age * over 21 years of age * unable to speak english fluently

Keywords: deviance regulation theory alcohol use alcohol consequences protective behavioral strategies college freshman
influenza virus - a multicenter registry

Conditions: Influenza Infection in Transplant Patients

Summary: the investigators purpose is to prospectively characterize influenza infections over a 3 year period in transplant patients using a registry system. the investigators plan to generate robust data on clinical features of upper and lower respiratory disease, antiviral therapy and its effects on disease outcome, as well as quantitative virologic data on shedding and antiviral resistance. the investigators also will study the long term sequelae of influenza infections and look at development of rejection.

this study will be a prospective, multi-center study conducted at investigator sites who comprise the influenza in transplant collaborative study group. this includes over 30 centers from across north america and europe. the co-ordinating center will be the university of alberta. we will aim to enrol 300 patients in the registry over a 3 year period. the following information will be gathered: 1. clinical information * baseline demographic information about the transplant (including immunosuppression, graft function) * comorbidities such as diabetes, obesity, chronic lung disease * symptoms of infection, radiologic features of infections * antiviral use * history of vaccination * outcomes such as hospitalization, icu admission, mechanical ventilation, death * long term outcomes: allograft function, chronic respiratory disease * laboratory parameters including lymphocyte count, immunoglobulin levels, renal function * adverse events - all serious adverse events occurring during the study (till day 180) will be reported. these include: a) hospitalization; b) congenital deformity; c) death; d) disability; and e) other adverse events the investigator considers serious. pregnancy during the follow-up period will also be reported. 2. virology * method of diagnosis (dfa, viral culture, pcr) * subtype of influenza virus (ie hxnx) * viral shedding by serial np swabs at day 0 (diagnosis), 3, 6, 11, 18, 28 (weekly thereafter if shedding persists) * quantitative pcr of np swabs (centrally at university of alberta) * antiviral resistance testing at first and last positive swabs 3. immunology - serum collection at disease onset and 4-6 weeks afterwards for * serology against circulating influenza viruses * production of hla alloantibodies significance: despite the recognized importance of influenza in transplant patients, there is actually very limited prospective data. this registry will represent the largest prospective data collection on influenza in transplant patients and will provide invaluable data on the clinical presentations, antiviral efficacy and other parameters related to influenza.

Eligibility criteria:
inclusion criteria: * solid organ transplant recipients on at least one immunosuppressive medication * hematopoietic stem cell transplant recipients - allogeneic or autologous * pediatric or adult * diagnosis of influenza infection by standard laboratory technique exclusion criteria: not able to comply with the protocol

Keywords: transplant influenza infection
screening and interventions in an acute care setting

Conditions: Depression; Medication Administered in Error; Cognitive Impairment

Summary: the purpose of this study is to: 1) evaluate the reliability and validity of ems screening for depression and cognitive impairment and 2) to develop a pilot ed intervention program to address the needs of older adults found to be at risk for depression and cognitive impairment.

many older adults (age over 64) have undetected health problems and lack basic prevention measures. failure to identify and treat these conditions can lead to unnecessary morbidity and mortality and a decreased quality of life. traditional screening and intervention programs, usually based in primary care providers' offices, have been insufficient, particularly in medically underserved populations. alternate sites for screening and intervention have begun to receive attention and may hold promise. the emergency medical services (ems) system is a unique, community-wide system that can be used to perform in-home evaluations to uniformly screen large numbers of vulnerable older adults during emergency responses. the emergency department (ed) is the entry point for access to medical and social services for many patients. recent programs have used the ems system to screen patients or the ed to screen and intervene with mixed results, but little has been done to rigorously evaluate an integrated program of ems screening that leads to focused ed interventions that promote the health of older adults. this proposed project builds upon the principal investigator's preliminary work and unique resources in rochester, ny to develop and evaluate a program of ems screening and ed interventions to help community-dwelling older adults with unmet needs. specifically, this study aims to: 1. implement an ems screening program to identify community-dwelling older adults' unmet needs during emergency responses, identifying patients with needs related to depression and dementia. 2. evaluate the test-retest reliability and concurrent criterion validity of ems screening for depression and cognitive impairment. 3. develop and refine an ems and ed intervention program that addresses the needs of older adults found by ems to be at risk for depression and cognitive impairment. upon completion, this study will have demonstrated the reliability and validity of ems screening for these conditions and will have proposed an ems and ed based intervention program template that can be applied to these and a wider range of geriatric disorders.

Eligibility criteria:
inclusion criteria: * age 65 or older, cared for by participating ems providers exclusion criteria: * too ill to participate, not transported to participating hospitals
comparative study of the hemorrhagic risk in patients over 75 years of age taking enoxaparin

Conditions: Venous Thromboembolic Disease

Summary: elderly subjects are at greater risk of thrombophlebitis than the general population, but also of bleeding when anticoagulant therapy is initiated. enoxaparin is one of the most widely used anticoagulants in the management of venous thromboembolism in the world. its use is not codified in the elderly, because too few studies have been carried out in people over 75 years old. for several years, enoxaparin in curative treatment has been administered at a reduced dosage of 4000 iu twice a day (and not at a standard dose of 100 iu / kg) at the geriatrics center of the crhu in strasbourg with the clinical impression of a reduction the risk of serious bleeding without reduction in therapeutic efficacy in this very elderly population. confirmation of a reduction in the risk of bleeding at this dosage could be the start of a change in prescribing practices, towards a more suitable dosage in the elderly.


Eligibility criteria:
inclusion criteria: * subjects of age\> = 75 years * having a weight\> = 45kg for women and\> = 57kg for men and a bmi \ 30 ml / min in cockcroft-gault, and having benefited from treatment with enoxaparin for deep vein thrombosis and / or pulmonary embolism between 01/01/2000 to 11/30/2021. * subject having been informed by posting in the service and / or via the welcome booklet and not having expressed his opposition to the reuse of his data. exclusion criteria: * subject having expressed opposition to participating in the study * history of heparin-induced thrombocytopenia in the last 100 days, * condition associated with a high risk of bleeding such as congenital or acquired blood pathology, * a recent hemorrhagic stroke, * a gastrointestinal ulcer, * the presence of a malignant tumor at high risk of bleeding, recent surgery of the brain, spine or ophthalmology, known or suspected oesophageal varices, arteriovenous malformations, a vascular aneurysm or major intraspinal or intracerebral vascular anomalies.

Keywords: thrombophlebitis anticoagulant therapy enoxaparin venous thromboembolic disease
towards optimal treatment of marfan syndrome

Conditions: Marfan Syndrome

Summary: the purpose of this study is to determine whether new magnetic resonance imaging techniques can be used as a biomarker of aortic disease severity in patients with marfan syndrome.


Eligibility criteria:
inclusion criteria: * mfs patients with a known fbn1 mutation * between 18-50 years of age exclusion criteria: * contraindication for mr imaging * mental retardation * pregnancy, or planned pregnancy during study period additional exclusion criteria healthy controls: - history of aorta disease

Keywords: magnetic resonance imaging aortic disease
to develop, implement and evaluate the polio demonstration project comprising of a community based intervention package for polio eradication in pakistan

Conditions: Polio; Polio Sero Conversion; Polio Sero Prevalence; Immunization Coverage

Summary: the objective of the projects is to develop and implement a package of interventions that will comprise of an augmented communication and counseling strategy coupled with private sector involvement and a combined oral polio vaccine and inject able polio vaccine approach during the polio campaigns followed by the evaluation of this project for acceptability, feasibility and effectiveness of the intervention package.

this particular project has been designed to address the bottlenecks through innovations to address community mobilization and demand creation on one hand and assess the synergistic immune enhancement potential of combining inject able polio vaccine (ipv) and oral polio vaccine (opv) in at-risk children. this project will be implemented in high risk union councils of karachi, district kashmore in sindh and bajaur agency in federally administered tribal areas (fata) this will be a three cell cluster randomized trial to achieve the objectives of the study. the first cell of the study will receive all the routine activities being carried out by the polio program, the second cell will receive an expanded intervention with community support groups, enhanced communication package, education and counseling and involvement of private sector. while the third cell will receive all of the interventions of second cell with a combined opv ipv approach during the polio immunization campaign through child health camps. we have calculated a total sample size of 120 clusters, 40 clusters per group for each study area i-e 120 for karachi, 120 for kashmore and 120 for bajaur. polio program in pakistan has well established and demarcated vaccination areas assigned to a vaccination team, each vaccination area usually covers about 200 children therefore the area of vaccination team will be considered as one cluster in the proposed study. the implementation of the project will be followed by impact assessment activities that will include post vaccination coverage surveys and immunity assessment activities and environmental sample collection. a total sample size of 5310 children has been calculated for the immunity studies for seroprevalance and 5130 for stool virus shedding

Eligibility criteria:
inclusion criteria: * healthy children aged 1 month to 5 years that reside within the study sites, and do not plan to travel away during entire the study period. exclusion criteria: * children with known thrombocytopenia or bleeding disorders; children acutely ill or with signs of acute infection (e.g. fever ≥ 101 f) at the time of nid and a diagnosis or suspicion of immunodeficiency disorder.

Keywords: polio disease intervention package polio sero prevalence and sero conversion polio high risk areas of pakistan
the effect of nasal carbon dioxide (co2) on nasal congestion in subjects with perennial allergic rhinitis

Conditions: Perennial Allergic Rhinitis

Summary: the purpose of this study is to evaluate the effect of nasal co2 on nasal congestion and other symptoms related to perennial allergic rhinitis.

a randomized study to evaluated the safety and effect of nasal carbon dioxide on nasal congestion using acoustic rhinometry in subjects with perennial allergic rhinitis. the acoustic rhinometry is an instrument that will be used to assess the levels of the nasal congestion in each subject. approximately 20 men and women ages 19-65 years old who have a history consistent with perennial allergic rhinitis requiring pharmacology for at least 2 years and meet all other eligibility criteria will be enrolled in this study. there will be six (6) visits to the clinic. there will be a screening visit, four (4) treatment visits, and an end of study visit. a subject's participation in the study may last up to 58 days. there will be four different doses given in this study. each subject will receive 3 different doses of the study drug and one dose of the placebo.

Eligibility criteria:
inclusion criteria: * have a history consistent with minimal 2 year history of perennial allergic rhinitis requiring pharmacotherapy. * positive skin test to perennial allergens (e.g. cats, dogs, house dust mite, etc.) * females of childbearing potential must commit to using an acceptable method of birth control and have a negative pregnancy test exclusion criteria: * history of asthma (other than mild or intermittent) * clinically significant nasal disorders * acute or significant sinusitis or upper respiratory infection within 14 days of randomization * have an existing serious medical condition (such as severe emphysema, other respiratory diseases, heart disease, etc.) that precludes participation in the study * use of certain medication s prior to randomization and during study participation * participation in prior study with nasal co2 * participation in another clinical study within 30 days of planned randomization date and for the duration of the study

Keywords: allergic rhinitis perennial allergic rhinitis allergies to perennial allergens allergies to perennial allergens (e.g. dog, cat, dust mites, etc.)
mechanisms of cardiac dysfunction in hiv and the effect of statins: a cardiac mri study

Conditions: HIV Infections

Summary: in this study, investigators plan to test whether statins can preserve and/or improve diastolic function among asymptomatic persons with hiv who are on anti-retroviral therapy. both myocardial fibrosis and myocardial steatosis are thought to contribute to diastolic dysfunction and eventually overt heart failure in hiv. hiv-positive participants will undergo cardiac mri/mrs imaging studies for the evaluation of myocardial fibrosis and myocardial steatosis prior to initiation of statin or placebo therapy and then two years after initiation of statin or placebo therapy. traditional markers of cardiovascular (cvd) risk, systemic immune activation/ inflammation, hiv-specific parameters (i.e. cd4 count), and markers of myocardial stretch/injury will be assessed in relation to cardiac mri/mrs outcomes.


Eligibility criteria:
inclusion criteria: * new enrollment in the reprieve trial exclusion criteria: * clinical diagnosis of hfpef or hfref, by subject report * standard contraindications to mri procedure based on mri patient procedure screening form - including history of severe allergy to gadolinium

Keywords: hiv diastolic dysfunction myocardial fibrosis statin
post icu follow up in patients with severe sars-cov-2 infection (covid-19)

Conditions: Covid19; Follow up; Rehabilitation

Summary: patients affected by new coronavirus infectious disease (covid) were mostly hospitalized in icu. this infection seems to cause widespread organ injury (i.e acute renal injury, neurological disorders, pulmonary embolism,...). it is therefore necessary to provide a framework for the follow up of patients. moreover sars-cov-2 infection consequences remain unknow at this time. study hypothesis is that covid alters determining factors (physical or psychological) of quality of life after icu hospitalisation. the aim of the study is to assess quality of life 3 months after icu hospitalization. secondary purposes of the study are 1) assessment of quality of life 6 months and the evolution between the third and the sixth months after icu hospitalization 2) description patients care after 3 and 6 months icu left and their clinical status 3) convening and providing a "platform" within several physicians (neurologist, biologist, pneumologist...) will be able to follow up patients and perform complementary investigations according to patients injuries.


Eligibility criteria:
inclusion criteria: * subject male or female ≥ 18 years old * patient hospitalized in the anesthesia-resuscitation department of the nhc for covid-19 from march 1, 2020. * patient (or his legal representative) having given his consent for the use of his data for the purposes of this research. exclusion criteria: * subject not hospitalized in intensive care * patient's refusal to participate in the study * inability to give informed information to the subject (subject in an emergency, difficulty understanding the subject, etc.) * subject under low protection

Keywords: sars-cov-2 follow up intensive care unit cohort
prevention of healthcare associated infections in bone marrow transplant patients

Conditions: Transplantation Infection

Summary: this study involves sampling bone marrow transplant patients, hospital workers and the patient room for microbes using swabs and other techniques. we send these samples to the laboratory, where they will use state-of-the art technology to identify and relate the microbes to each other. this study also involves putting copper, nickel, or titanium into some hospital rooms, and seeing whether these metals influences the growth of microbes. some equipment in the hospital room, such as faucets and soap dispensers will be replaced by sensor-based (e.g. touchless) controls.

bacteria and other microbes are everywhere, the majority of which are harmless. they live on our bodies, on everyday objects, in food, and in our environment. they are passed around through the many interactions with other people and our surroundings. some are even beneficial, helping us digest our food or protecting us from infections caused by harmful microbes. in rare instances, some of the harmful microbes can cause infections. when a microbe causes an infection while we are in healthcare facilities, they are called "healthcare-associated infections", or "hais". examples that you may have heard of include clostridium difficile, and mrsa (methicillin-resistant staphylococcus aureus). vancouver general hospital already has some of the lowest hai rates in the country. we have dedicated hospital workers that do a great job at preventing hais, but we are always looking for ways to be even better.

Eligibility criteria:
inclusion criteria (patients): * undergoing allogenic bone marrow transplant for acute myeloid leukemia * will be admitted to the leukemia and bone marrow transplant service at vancouver general hospital * admission to the ward anticipated to be approximately 28 days exclusion criteria (patients): * allergies to copper, nickel or titanium * patients admitted for stays anticipated to be less than 28 days inclusion criteria (health care worker): * undergoing allogenic bone marrow transplant for acute myeloid leukemia * caring for patient enrolled in the study as a primary nurse exclusion criteria (health care worker): * allergies to copper, nickel or titanium
light diffraction glasses in preventing and controlling myopia in adolescents

Conditions: Myopia Progressing

Summary: this study aims to evaluate the effectiveness of lenses with light diffraction glasses in controlling the progression of myopia in children and adolescents, and to explore the feasibility of effective design, and apply personalized frame lenses for myopia prevention and control.


Eligibility criteria:
inclusion criteria: 1. age: 6-8 years old; 2. after using 1% cyclohexanone hydrochloride eye drops (saifeijie) for ciliary muscle paralysis, binocular spherical power were within 0.00d\~-1.75d, binocular cylinder power ≤ 1.50d, the anisometropia is less than 1.50d, the progression of myopia in the past year is greater than 0.5d, the best corrected far vision is at least 4.8, and the near vision is at least 5.0; 3. within 6 months, the myopia prevention and control methods such as multifocal glasses, orthokeratology, defocusing flexible glasses, progressive glasses, atropine eye drops, red light and acupuncture and moxibustion treatment were not used; 4. the subject has a willingness to receive treatment and an informed consent form is signed by their legal guardian. exclusion criteria: 1. diagnosed constant strabismus; 2. diagnosed pathological myopia; 3. other congenital eye diseases; 4. researchers believe that the patients have other reasons that are not suitable for inclusion in the project.
study of efficacy and safety of lde225 in adult patients with relapsed/refractory acute leukemia

Conditions: Acute Leukemias

Summary: the study will evaluate the efficacy, safety and tolerability of two dosing schedules of lde225 in patients with relapsed/refractory acute leukemia or elderly patients with untreated acute leukemia.


Eligibility criteria:
inclusion criteria: * subjects must have relapsed or primary refractory non-m3 acute myeloid leukemia or relapsed or refractory non-t-cell acute lymphoblastic leukemia or untreated acute myeloid leukemia in elderly patients. * performance status of 0, 1 or 2 per who classification. * adequate renal and liver function. * adequate blood creatine kinase value (ck \< 1.5uln) exclusion criteria: * allogeneic stem cell transplantation within the last 4 months and/or active graft versus host disease requiring systemic immunosuppressant therapy, or autologous stem cell transplantation within the last 4 weeks. * patient for which immediate allogeneic stem cell transplantation is the treatment of choice. * pregnant or nursing (lactating) women. * active cns leukemic involvement

Keywords: acute myeloid leukemia aml acute lymphoblastic leukemia all leukemia acute lde225 adult patients relapsed/refractory
same day dosing of pegfilgrastim in breast cancer patients undergoing chemotherapy (tac)

Conditions: Breast Cancer; Fever; Neutropenia

Summary: the purpose of this study is to provide data on the safety and efficacy of pegfilgrastim when administered on the same day versus the next day of chemotherapy, as measured by the duration of grade 4 neutropenia.


Eligibility criteria:
inclusion criteria: - breast cancer, previously untreated exclusion criteria: - active infection requiring treatment with systemic (intravenous or oral) anti-infectives (antibiotic, antifungal, antiviral) within 72 hours of chemotherapy - prior malignancy within the last 5 years, with the exception of surgically cured basal/squamous skin cell carcinoma, ductal carcinoma in situ of the breast and/or carcinoma of the cervix in situ - history of impaired cardiac status (e.g., severe heart disease, cardiomyopathy or congestive heart failure) - major surgery within 2 weeks prior to randomization - previous exposure to cytokines within two weeks prior - concurrent use of other investigational agents

Keywords: neulasta® chemotherapy tac amgen