Kornimate/medical-research-clean huggingface dataset:
muscle activity during load carriage in rotc cadets

Conditions: Back Pain

Summary: army rotc cadets who are currently enrolled in military science courses will be asked to participate in this experimental research design. a total of 30 healthy cadets consisting of approximately 24 males and six females will be recruited, as this will provide an accurate representation of the overall army demographics with 17% being female. paperwork: after providing consent, participants age and gender will be documented, and height and weight will be measured and documented. participants will complete a modified version of the modified oswestry low back pain disability questionnaire, which has been adjusted to be more specific to the military population. the questionnaire will be filled out indicating the cadet's current level of pain. they will then complete the same questionnaire indicating their pain within the last year. protocol: first, the skin will be prepared and surface electromyography (emg) electrodes will be placed. dynamic, surface emg data will be obtained of the gluteus medius, gluteus maximus, erector spinae, rectus femoris, and biceps femoris muscles in accordance with seniam (surface electromyography for the non-invasive assessment of muscles) guidelines. skin preparatation will consist of trimming hair if the skin surface at which the electrodes have to be placed is covered with hair. next, the skin will be cleaned with alcohol. the skin will be allowed to dry prior to electrode placement. lastly, skin will be abraded to reduce impedance. following electrode application, participants will complete five minutes of light activity on a bike or treadmill for warm-up. next, in order to normalize the data, manual muscle tests will be performed for each of the six muscles being test. then, participants will walk at a speed of four miles per hour for 10 seconds as a dynamic measurement for normalizing the data. after completion of the two normalization protocols, participants will complete a five kilometer (3.1 mile) walk on a treadmill at a speed of three miles per hour, with and without a 35 lb. load carried in a traditional rucksack. the load conditions will be randomized and counterbalanced in order to mitigate effects of fatigue, and the conditions will be performed in two separate sessions (separated by 24-48 hours).


Eligibility criteria:
inclusion criteria: * current enrollment in military science courses and member of army rotc exclusion criteria: * current musculoskeletal injuries
adeno-associated virus (aav) antibody study in subjects otc deficiency, gsdia, and wilson disease

Conditions: Ornithine Transcarbamylase Deficiency; Wilson Disease; Glycogen Storage Disease Type IA

Summary: the objective of this observational study is to evaluate the seroprevalence of anti-aav antibodies in subjects with ornithine transcarbamylase (otc) deficiency, glycogen storage disease type ia (gsdia), and wilson disease

the study is primarily designed to follow a virtual model, in which screening will take place over a telephone/video call. the study will comprise a single home health visit, either on the same day as screening or within 30 days of enrollment. a safety follow-up may occur up to 5 days after day 1 assessments are completed.

Eligibility criteria:
inclusion criteria: * diagnosis of otc deficiency, gsdia, or wilson disease. * provide informed consent after the nature of the study has been explained, and prior to any research-related procedures. exclusion criteria: * prior exposure to an aav-based gene therapy. * concurrent or previous participation in another ultragenyx clinical study. * recipient of a liver transplant. * presence or history of any condition that, in the view of the investigator, would interfere with participation, pose undue risk, or would confound interpretation of results.
b-mode ultrasound, sono-elastography, and diffusion-weighted imaging mri in thyroid nodules

Conditions: Thyroid Nodule

Summary: to compare the accuracy of the conventional ultrasound 'ti-rads', us elastography, dwi mri, and its adc value in characterization and differentiation of thyroid nodules.

thyroid nodules are one of the most common endocrine carcinomata (1) most thyroid tumors have a good prognosis if early diagnosis and timely treated (2) an ultrasound (us) exam is a safe, non-invasive imaging technique for detecting thyroid nodules (3) however, still there are no dependable criteria to discriminate malignant from benign lesions. (4) in 2009, horvath et al proposed the thyroid imaging report and data system (ti-rads). the new version of ti-rads was launched by acr in 2017. (5) color doppler ultrasound is also used to differentiate benign from malignant thyroid nodules. the presence of intra-nodular vascularity (type 1b) was considered close to be malignant (6) us elastography is a novel tool to increase the diagnostic value of ultrasound and as an adjuvant tool (7) shear wave elastography evaluates elasticity through the propagation speed of shear waves, with the wave speed being faster in hard tissue (8) conventional t1-and t2-weighted mr imaging can-not differentiate benign from malignant nodules (9) diffusion-weighted imaging (dwi) is a non-invasive tool used to distinguish benign from malignant nodules (10). malignant thyroid nodules usually have a lower adc value attributed to cellular density and tissue perfusion. (11) combining subjective mri features with a quantitative measurement could improve the diagnostic yield of dw-mri (12) the cytological examination by fine-needle aspiration (fna) has become a reliable tool to diagnose thyroid cancers (2) suspicious cytological findings reach up to 30% of all aspirated nodules, suggesting the need for less invasive methods (13)

Eligibility criteria:
inclusion criteria: * patients should have a normal bleeding profile. * presence of solitary or multiple nodules in the thyroid gland. * in the case of patients having multiple nodules, the nodule having suspicious ultrasound features (having ti-rads score 4 or 5) was selected for further analysis. * the nodules were either solid or mixed (containing both solid and cystic parts) with a predominant solid component exclusion criteria: * contraindicated biopsy (as thrombocytopenia or bleeding disorder). * patient with cystic and mainly cystic nodules (ti-rads 1 nodules). * nodules with complete shell-calcification which may cause color mapping artifacts. * mri contraindications such as claustrophobia, mr-incompatible pacemakers, and mr-incompatible prosthetic heart valves. * patients with recurrent thyroid masses. * history of operative procedure, chemo, or radiotherapy on the thyroid gland. * declined consent.

Keywords: elastography dwi thyroid thyroid ultrasound
european union (eu) post-market study on easyband®

Conditions: Morbid Obesity

Summary: the purpose of this study is to collect additional safety, performance and effectiveness data of the easyband gastric band medical device in the treatment of morbid obesity in 4 european countries where the device is a ce marked approved product.


Eligibility criteria:
inclusion criteria: * demonstrated failure in losing weight with non-invasive therapies * bmi ≥ 40 kg/m2, or bmi ≥ 35 kg/m2 and \< 40 kg/m2 with one or more significant medical conditions related to obesity exclusion criteria: * patients with bmi greater than 60 kg/m2 * patients who are not indicated for laparoscopic bariatric surgery * patients with known allergies to implant materials such as silicone and peek * patients whose abdominal structures have been damaged during preceding surgical procedures * pregnant women * patients under the age of 18 years * patients treated with steroids * patients addicted to alcohol or drugs, or who are mentally unstable, or who may not comply with the follow-up and dietary restrictions * patients already implanted with a device sensitive to radio-frequency emissions such as implanted pacemaker, defibrillators, cochlear implants, implantable pumps etc
goat infant formula feeding and eczema (the giraffe study)

Conditions: Dermatitis, Atopic; Eczema, Infantile; Infant Development; Child Development

Summary: to determine the relative risk of developing atopic dermatitis in infants fed a study formula based on whole goat milk compared to infants a study formula based on cow milk protein.

the study is a randomized, double-blind, parallel-group trial to study the effect of feeding infants goat milk or cow milk formula in the first year of life on the risk of allergy and other health outcomes, including growth, tolerance and quality of life in the first 5 years of life.

Eligibility criteria:
inclusion criteria: * having obtained written informed consent (signed and dated) of the child's parent(s)/caregiver(s), indicating that the child's parent(s)/caregiver(s) has/have been informed of all pertinent aspects of the study * born full term (≥37 weeks +0 days and ≤ 41 weeks +6 days of gestation) * age at enrolment \< 3 months of age (\<90 days) * birth weight ≥2.5 kg and ≤4.5 kg * born from a singleton pregnancy * child's parent(s)/caregiver(s) is/are of legal age of consent * the child's parent(s)/caregiver(s) have sufficient local language skills to understand the study information, the informed consent, and to comply with the study procedure * the child's parent(s)/caregiver(s) is/are willing and deemed able to fulfil the requirements of the study protocol and procedures * mother has expressed the intention to partially (in combination with breastfeeding) or fully formula-feed exclusion criteria: * diagnosed disorder considered to interfere with nutrition, growth or development of the immune system * participation of the child in any other interventional trial or participation of the mother in any intervention trial with child follow-up * infant has a doctor's diagnosis of atopic dermatitis or a severe widespread skin condition prior to randomization that would make the detection or assessment of atopic dermatitis difficult * infant has consumed an infant formula for more than 4 weeks prior to enrolment * cow milk allergy or intolerance * institutionalized infant

Keywords: atopic dermatitis healthy term infants infant formula infant development child development
anticoagulation in ich survivors for stroke prevention and recovery

Conditions: Intracerebral Hemorrhage; Atrial Fibrillation

Summary: primary aim: to determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ich and atrial fibrillation (af). secondary aim: to determine if apixaban, compared with aspirin, results in better functional outcomes as measured by the modified rankin scale.

aspire is a randomized, double-blinded, phase iii clinical trial designed to test the efficacy and safety of anticoagulation, compared with aspirin, in patients with a recent ich and non-valvular af. seven hundred patients will be enrolled over 3.5 years and followed for study outcomes for a minimum of 12 months and maximum of 36 months. the primary efficacy outcome is any stroke (hemorrhagic or ischemic) or death from any cause. the secondary efficacy outcome is the change in the modified rankin scale score. recruitment will take place at sites coordinated through the nih/ninds strokenet.

Eligibility criteria:
inclusion criteria: * age at least 18 years * intracerebral hemorrhage (ich) (including primary intraventricular hemorrhage) confirmed by brain ct or mri * can be randomized within 14-180 days after ich onset * non-valvular af (defined as atrial fibrillation or atrial flutter), documented by electrocardiography or a physician-confirmed history of prior af * provision of signed and dated informed consent form by patient or legally authorized representative * for females of reproductive potential: use of highly effective contraception exclusion criteria: * index event is hemorrhagic transformation of a brain infarction or hemorrhage into a tumor * history of earlier ich within 12 months preceding index event * active infective endocarditis * clear indication for anticoagulant drugs (e.g., requires anticoagulation for deep vein thrombosis or pulmonary embolism) or antiplatelet drugs (e.g., requires aspirin or clopidogrel for recent coronary stent). * previous or planned left atrial appendage closure * clinically significant bleeding diathesis * serum creatinine ≥2.5 mg/dl * active hepatitis or hepatic insufficiency with child-pugh score b or c * anemia (hemoglobin \<8 g/dl) or thrombocytopenia (\<100 x 10\^9/l) that is chronic in the judgment of the investigator * pregnant or breastfeeding * known allergy to aspirin or apixaban * concomitant participation in a competing trial * considered by the investigator to have a condition that precludes safe or active participation in the trial * persistent, uncontrolled systolic blood pressure (≥180 mm hg) * ich caused by an arteriovenous malformation (avm) that has not yet been secured
general anesthesia with or without local ear block in middle ear surgeries

Conditions: Tympanum; Perforation

Summary: background: proper selection of anesthetic technique is important in middle ear microsurgery. controlled hypotension in ear surgery decreases blood loss with improved quality of the surgical field, however, it is associated with resistance to vasodilators and delayed recovery from anesthesia. the use of local anesthetic technique alone in middle ear surgery decreases bleeding and reduces postoperative pain, however, pain on injection, noise, and head-neck position had been reported with the increased risk of patient injuries. this study aimed to compare the effects of local ear block combined with general anesthesia versus general anesthesia alone, regarding intraoperative hemodynamics, anesthetic consumption, recovery characteristics, postoperative pain, adverse effects and postoperative complications.

eighty adult patients undergoing middle ear surgery (tympanoplasty with or without mastoidectomy) were enrolled in the study. patients were randomized into two equal groups (40 patients each). a standardized general anesthetic technique was used in both groups. group i, received general anesthesia combined with ear block using 10 ml of 0.25% bupivacaine and (group ii), received general anesthesia alone combined with ear block using 10 ml saline. propofol 2-3 mg /kg was administered to induce anesthesia, which was maintained using isoflurane. hemodynamic variables, surgical conditions including the quality of the operative field, intraoperative fentanyl, vasodilators (propranolol and nitroglycerine), isoflurane consumption, recovery time, postoperative pain, total analgesics consumption and postoperative complications were recorded

Eligibility criteria:
inclusion criteria: * asa i or ii status, * scheduled for tympanoplasty with or without mastoidectomy exclusion criteria: * patient refusal, * known allergy to local anesthetics * cardiovascular diseases (myocardial infarction, hypertension and valvular heart diseases) --- cerebrovascular diseases (including transient ischemic attacks), renal, hepatic insufficiency or coagulation abnormality.
research on burden of disease for patients with myocardial infarction combining dyslipidemia in china

Conditions: Myocardial Infarction; Dyslipidemias

Summary: this study is medical record review and questionnaire survey on the economic burden on chinese patients with myocardial infarction accompanied by dyslipidemia in a real-world environment. the primary objective of the study is to investigate the economic burden of disease on patients and the factors influencing it, which may include the mode of treatment for dyslipidemia, drugs for the secondary prevention of myocardial infarction, the outcome of treatment for dyslipidemia, adverse drug reactions and major cardiovascular events. the secondary objectives of the study include: 1. patient compliance with medication; 2. health-related quality of life (hrqol) in patients.

this study is a multicenter retrospective cohort survey study using a cross-sectional design. it is conducted mainly by a medical record review, questionnaire survey and medical examination to collect data.

Eligibility criteria:
inclusion criteria: * patients were hospitalized because of acute myocardial infarction in a study hospital between january 1, 2016 and december 31, 2016. if a patient was hospitalized because of multiple occurrences of myocardial infarction during this period, his/her initial hospitalization because of myocardial infarction will be considered index hospitalization. patients undergo continuous screening in a reverse order based on time. * patients did not die during "index hospitalization". * patients had low-density lipoprotein≥1.8 mmol/l shown by the first measurement of blood lipids or were using lipid-regulating drugs at the first measurement of blood lipids during "index hospitalization" in 2016. * patients consent to participate in this study and grant informed consent; or the family of a patient who died before telephone screening consents to provide relevant information and grant informed consent. exclusion criteria: * patients participated in interventional clinical trials after "index hospitalization". * patients had paid \<5 visits to the outpatient clinics of a study hospital within one year since discharge after "index hospitalization" (if patients who have died within one year since discharge after "index hospitalization"). * there is a barrier to communication with a patient or his/her family (if the patient has died); a patient or his/her family (if the patient has died) cannot correctly understand and answer questions normally.

Keywords: myocardial infarction dyslipidemia
examination of valve insufficiency before and after mitraclip or tavi procedure by 3d echocardiography compared to mri

Conditions: Development of Standardized Assessment TAVI and MitraClip Procedures by Echocardiography; Aortic Stenosis; Mitral Valve Insufficiency

Summary: aim of the study is the definition of criteria for a standardized assessment of heart function by 3d echocardiographic procedures. standardized criteria will be defined to assess aortic valve insufficiency after tavi and success of mitral valve replacement respectively.

echocardiography: ge healthcare vivid e9

Eligibility criteria:
inclusion criteria: * patients with severe symptoms of an aortic stenosis who underwent catheter based implantation of an aortic valve * patients who are planned to undergo a reconstruction of the mitral valve with the mitraclip system * patients who are aged above 18 years and legally competent * signed informed consent exclusion criteria: * patients with previous myocard infarction, previous heart surgeries, malignity or valvular abnormities \> stage 1 * patients with atrial fibrillation * pregnant and breast-feeding women * patients with disturbed central nerve system * patients with pacemaker, implants, ferrous clamps,insulin pump * patients with tattoo * patients with claustrophobia * patiens with asthma
role of nutrient transit in hyperinsulinemic hypoglycemia

Conditions: Post-Bariatric Hypoglycemia

Summary: severe hypoglycemia (low blood sugar)after gastric bypass surgery is an increasingly recognized condition, characterized by symptoms of hypoglycemia after eating and inappropriately elevated insulin concentrations that occur at the time of hypoglycemia. severe hypoglycemia can be dangerous and debilitating and can also impact cognitive function. at the moment no medical therapies have been developed for this disorder. determining why some but not other patients develop this condition would allow for improved prediction, prevention, and treatment approaches. the purpose of the study is to understand the physiological changes observed in those patients who undergo gastric bypass and develop symptomatic hypoglycemia.


Eligibility criteria:
inclusion criteria: * male or female patients 18-70 years of age * post-bariatric surgery more than 6 months prior to signing the informed consent (not required for non-surgical controls) * documented history of hyperinsulinemic hypoglycemia (not required for post-bariatric and non-surgical controls) exclusion criteria: * patients currently using sulfonylureas or other medications that may interfere with glucose metabolism within 5 half-lives of drug. * participation in any clinical investigation within 4 weeks prior to dosing * history of or current insulinoma * active infection or significant acute illness within 2 weeks prior to dosing * female patients who are pregnant or lactating * women of childbearing potential and not utilizing effective contraceptive methods * inadequate end organ function as defined by: serum creatinine \>2.0 mg/dl, alanine transaminase (alt) and aspartate aminotransferase (ast) \> 2 x upper normal limit * allergy to test meal or medications used in the study
waitlist-control trial of smartphone cognitive behavioral therapy (cbt) for body dysmorphic disorder (bdd)

Conditions: Body Dysmorphic Disorder

Summary: the investigators are testing the efficacy of smartphone-delivered cognitive behavioral therapy (cbt) treatment for body dysmorphic disorder (bdd). the investigators hypothesize that participants receiving app-cbt will have greater improvement in body dysmorphic disorder symptom severity than those in the waitlist condition at treatment endpoint (week 12).

the primary aim of this study is to test the efficacy of a smartphone-based cognitive behavioral therapy (cbt) treatment for adults with body dysmorphic disorder (bdd) recruited nationally. in a prior study (clinical trials identifier # nct03221738), the investigators developed and pilot-tested the feasibility, acceptability, and preliminary efficacy of a cbt for bdd app in an open pilot trial. the investigators are now further testing these outcomes in a randomized controlled trial. eligible subjects (n= 64) will be randomly assigned to 12-weeks of smartphone-delivered cbt for bdd either immediately, or after a 12-week long waiting period (50/50 chance).

Eligibility criteria:
inclusion criteria: * at least 18 years of age * current diagnosis of primary body dysmorphic disorder (bdd), based on a clinical structured diagnostic interview * currently living in the united states exclusion criteria: * psychotropic medication changes within 2 months prior to enrollment (participants taking psychotropic medication must have been on a stable dose for at least 2 months prior to enrollment and not change medication during study period) * past participation in 4+ sessions of cognitive behavioral therapy (cbt) for body dysmorphic disorder (bdd) * current severe substance use disorder * lifetime bipolar disorder or psychosis * acute, active suicidal ideation as indicated by clinical judgment and/or a score \>2 on the suicidal ideation subscale of the columbia-suicide severity rating scale (c-ssrs). * current severe comorbid major depression, as indicated by clinical judgment and/or a quick inventory of depressive symptomatology- self report (qids-sr) total score ≥ 21 * concurrent psychological treatment * does not own a supported smartphone with a data plan * lack of technology literacy that would interfere with ability to engage with smartphone treatment