Kornimate/medical-research-clean huggingface dataset:
the effect of yoga therapy on post-operative side-effects among women with breast cancer

Conditions: Breast Cancer; Yoga Therapy; Shoulder Joint Motion; Scar Contracture

Summary: the present study evaluates the effect of yoga therapy on scarring contractures and shoulder joint motion and range in women diagnosed with breast cancer. a single-blinded prospective, randomized controlled trial will be used.

to conduct a study to evaluate the effect of yoga therapy on scarring contractures and shoulder joint motion and range in women diagnosed with breast cancer using a single-blinded prospective, randomized controlled trial. the aims are to test: 1. to evaluate the impact of yoga therapy on scarring contractures and range of motion in shoulder joints among women recovering from surgical treatment of breast cancer. 2. to evaluate the impact of yoga therapy on health-related quality of life and symptom distress. primary hypotheses 1. intervention and control groups mean scores on measures of shoulder movement range will show no differences at baseline or significant changes at the immediate post-intervention, 3rd, 6th, and 12th month post-intervention. 2. mean scores of quality of life and symptom distress between intervention and control groups at the immediate post-intervention, 3rd, 6th, and 12th month post-intervention will show no differences relative to baseline.

Eligibility criteria:
inclusion criteria: * cantonese-speaking chinese patients * were newly diagnosed with breast cancer * had completed breast cancer surgery plus chemotherapy * were able to give consent exclusion criteria: * patients who have residual breast tumors or loco-regional metastasis after treatment * who were practicing yoga since the diagnosis of breast cancer * or are otherwise physically unable to yoga

Keywords: yoga therapy breast cancer scar contracture shoulder joint motion
pre-exposure prophylaxis accessibility research and evaluation 2

Conditions: PrEP Uptake; HIV Seronegativity

Summary: this study is a controlled, un-blinded, two-arm, randomized (1:1) clinical trial to determine if providing high-risk subjects with a calculated risk score changes the likelihood of pre-exposure prophylaxis (prep) uptake.

all men who have sex with men (msm) and male-to-female transgender individuals who have sex with men who present to tnc for hiv testing and are at risk for hiv will be offered enrollment in this study (see study schema). upon enrollment, subjects will be given an ipad-based computerized questionnaire that assesses their risk perception, demographics, risk behavior, and perception of whether they are a candidate for prep. upon completion of the survey they will be randomized into 1 of 2 arms. subjects in the intervention arm will receive the results of their risk score based on a risk calculator developed at ucsd and the center for disease control and prevention's tool for assessing risk for contracting hiv (arch, formerly known as the hiv incidence risk index for msm, or hiri-msm), whereas subjects in the control arm will not receive this information. both groups will receive standard risk reduction counseling. subjects will be contacted by phone 2 months after enrollment to determine whether they initiated prep or not, to re-assess their risk perception, and to provide a link to a final online survey. if subjects have not completed the survey 4 weeks after being provided with the link, they will receive a text-message reminder. the analysis of the data will begin 12 weeks after the last study subject is enrolled.

Eligibility criteria:
inclusion criteria: * man or transgender m to f who has sex with men. * age 18 years or older. * subjects must have substantial ongoing risk of acquisition of hiv as evident by one or more of the following: one or more episode of unprotected anal intercourse with a hiv-infected partner or a partner with unknown hiv status within the last 6 months * negative for hiv infection by rapid hiv test exclusion criteria: * unable to give informed consent. * signs or symptoms suggestive of acute hiv infection * any other reason or condition that in the opinion of the investigator would interfere with participation, complicate interpretation of study outcome data, or otherwise interfere with achieving the study objectives.

Keywords: prep risk score self-perception
comparison of warfarin dosing using decision model versus pharmacogenetic algorithm

Conditions: Atrial Fibrillation; Pulmonary Embolism; Deep Vein Thrombosis

Summary: this is a prospective comparison of clinician dosing and a pharmacogenetic algorithm in diagnosed patients requiring warfarin therapy.

diagnosed patients with atrial fibrillation, pulmonary embolism, or deep venous thrombosis requiring warfarin therapy will be consented and a tube of blood for dna analysis will be drawn. the clinician dosing group will not be eligible to obtain the pharmacogenetic results and the algorithm group will have their warfarin pharmacogenetic snps performed and integrated into the algorithm and the warfarin dose will be calculated. outcomes of patients receiving both methods will be gathered and statistically analyzed.

Eligibility criteria:
inclusion criteria: * diagnosed patients with atrial fibrillation, deep venous thrombosis, or pulmonary embolism requiring warfarin therapy exclusion criteria: * patients with atrial fibrillation, deep venous thrombosis, or pullmonary embolism requiring warfarin therapy who do not consent to participate

Keywords: mechanical valve
prospective, randomized, multicenter, control study to assess the efficacy and safety of tacrolimus in induction and maintenance phase treatment in lupus nephritis

Conditions: Kidney Diseases; Lupus Nephritis; Tacrolimus; Induction Phase; Maintenance Phase

Summary: the purpose of this study is to compare the efficacy and safety of tacrolimus vs intravenous cyclophosphamide pulses treatment for the induction therapy of ln(iii,iv,v). to compare the efficacy and safety of tacrolimus vs azathioprine for the maintenance therapy of ln(iii,iv,v).


Eligibility criteria:
inclusion criteria: 1. subjects of either sex, 14-65 years of age; 2. diagnosis of sle according to the acr criteria(1997); 3. kidney biopsy within the 6 months prior to first randomization with a histologic diagnosis (isn/rps 2003 classification of ln) class iii, iv, v; 4. class iv ln: proteinuria \>1g/24hr or scr\>115umol/l; 5. class iii or v ln: proteinuria \>2g/24hr or scr\>115umol/l; 6. provision of written informed consent by subject or guardian. exclusion criteria: 1. inability or unwillingness to provide written informed consent ; 2. known hypersensitivity or contraindication to tacrolimus, cyclophosphamide , azathioprine, corticosteroids; 3. usage of immunosuppression therapy (mmf, ctx, cysa, mtx ect) for more than 1 week within 1 month prior to first randomization; 4. pregnancy, nursing or use of a non-reliable method of contraception; 5. continuous dialysis starting more than 2 weeks before randomization into the induction phase and/or continuous dialysis with an anticipated duration of more than 8 weeks; 6. previous kidney transplant or planted transplant; 7. scr \> 4mg/dl (353umol/l); 8. active hepatitis, with liver dysfunction; 9. diagnosed dm; 10. participation in another clinic trial and/or receipt of investigational drugs within 4 weeks prior to screening .

Keywords: tacrolimus lupus nephritis
determine feasibility of quantifying apoptosis and bcl-2 expression in ctcs in women with metastatic breast cancer

Conditions: Metastatic Breast Cancer

Summary: we are trying to develop better ways to detect when cancer therapies are working.


Eligibility criteria:
inclusion criteria: 1.females at least 18 years of age 2 diagnosis of metastatic breast cancer 3.ecog score of 0-2 4.treating oncologist has decided to initiate any new systemic therapy with emphasis on recruiting patients commencing a taxane-based regimen. taxine-based therapy may be docetaxel or paclitaxel, and it can be given on any schedule,including weekly or every 3 weeks. other treatment can include non-taxane chemotherapy or trastuzumab-with or without other therapy. 5.patient is willing to return for one or more additional \~18 ml blood draw (s) at 24-48-, and /or 72 hours and \~3-4 weeks after the initiation of therapy.at a minimum, patients must donate blood at baseline, one intermediate interval (24, 48, 72 hr) and at \~3-4 weeks 6.signed informed consent form - exclusion criteria: patient is unable and unwilling to provide a blood specimen at a minimum of one of the intermediate blood draw time points at 24, 48, or 72 hours -
pathogen detection in infectious uveitis

Conditions: Infectious Panuveitis; Infectious Iridocyclitis

Summary: infectious uveitis is a very important blinding disease. some people who have been diagnosed with idiopathic uveitis may also have the activity of pathogens in the eye. however, due to the limitation of the amount of ocular samples, it is difficult to make a rapid and effective diagnosis of infection.current study is to explore the infective cause of uveitis in china by using a broad diagnostic approach of detection.

infectious uveitis is a very important blinding disease. some people who have been diagnosed with idiopathic uveitis may also have the activity of pathogens in the eye. however, due to the limitation of the amount of ocular samples, it is difficult to make a rapid and effective diagnosis of infection. the study is to explore the infective cause of uveitis in china by using a broad diagnostic approach of detection, including multiple molecular bio-techniques. we also plan to explore the distribution of pathogens in infectious uveitis.

Eligibility criteria:
inclusion criteria: * patient at a referal hospital eye clinic with clinically suspected infectious uveitis exclusion criteria: * patients not eligible for the inclusion criteria * confirmed auto-immune uveitis

Keywords: infectious uveitis pathogen pcr
high flow nasal cannula versus nasal continuous positive airway pressure for respiratory support of preterm neonates

Conditions: Respiratory Distress Syndrome, Newborn

Summary: this work is designed to: 1. evaluate the efficacy of hhhfnc in comparison with ncpap in preterm neonates. 2. investigate hemodynamic changes associated with hhhfnc in comparison to ncpap in preterm neonates during periods of non-invasive respiratory support and after being off support.

there is a preference of using noninvasive modes of ventilation for management of respiratory distress syndrome (rds) in preterm infants and of weaning of ventilated neonates as soon as possible to non-invasive modes. yet, little is known about which non-invasive mode is better and the hemodynamic changes that occur to the infants secondary to these modes. the study provides an evaluation of the efficacy of heated, humidified high flow nasal cannula (hhhfnc) in comparison to nasal continuous positive airway pressure (ncpap) in preterm infants. secondary aim is to assess echographic, cerebral blood flow and mesenteric blood flow changes during hhhfnc versus ncpap.

Eligibility criteria:
inclusion criteria: infants are eligible if they meet the following criteria: 1. gestational age ≤ 35 weeks. 2. preterm neonates in need for non invasive ventilation whether they were on invasive ventilatory support before or not. exclusion criteria: preterm neonates with evidence of any of the following will be excluded: 1. major upper or lower airway anomalies. 2. significant congenital anomalies including cardiac, abdominal or respiratory. 3. hemodynamically significant patent ductus arteriosus (pda): diagnosed if there is colour doppler echocardiographic evidence of left to right ductal shunt, ductal diameter \>1.5mm/kg or left atrial/aortic root ratio \>1.4

Keywords: hemodynamic changes high flow nasal cannula nasal continuous positive airway pressure respiratory distress syndrome prematurity
"pain and emotional changes on relationships between anxiety and olfaction"

Conditions: Anxiety

Summary: introduction: this prospective study aimed to assess the impact of olfaction on providing positive emotional responses and reducing dental anxiety and pain. material: a randomized double-blinded controlled study was enrolled on female patients. the olfaction was stimulated via lavender essential oils. patients were divided into lavender and control groups. patients in lavender group inhaled 2 % lavender vapors. in control group, patients inhaled distal water vapors. the variables included pain, anxiety, and vital signs. anxiety was measured through modified dental anxiety scale (mdas) and speilberger state-trait anxiety inventory (stai) questionnaires. pain was evaluated through visual analog scales (vas). vital signs included the systolic (sbp) and diastolic blood pressure (dbp), heart rate (hr), respiratory rate (rr), and oxygen saturation (spo2). all variables were assessed before the intervention, 20 minutes after inhalation of vapors, and at the end of dental settings. the last evaluation was on the day after visits. p-values \< 0.05 were considered significant.

abstract: background: the purpose of the study was to determine to what extent olfactory aromatherapy reduces the intensity of dental pain and the level of dental anxiety. it also attempted to corelate between olfactory aromatherapy, stages of dental visits, and various dental procedures. methods: female patients were enrolled in a randomized controlled study. olfactory aromatherapy was performed using lavender oils. patients were randomly assigned to one of two groups: the lavender group, in which patients inhaled 2% lavender vapors, and the control group, in which patients inhaled water vapors. pain score, anxiety score, and changes in vital signs were among the predictable variables. anxiety and pain were assessed using the modified dental anxiety scale (mdas), speilberger state-trait anxiety inventory (stai), and visual analog scales (vas). the vital signs were systolic (sbp) and diastolic (dbp), heart rate (hr), respiratory rate (rr), and oxygen saturation (spo2). variables were evaluated before inhalations, 20 minutes after inhalations, at the end of settings, and on the following day.

Eligibility criteria:
inclusion criteria: * adult females over 18 years, * attending morning sessions of clinics (9 am), * liable for administration of local anesthesia, tooth preparation either for: 1. filling procedures or crown preparations 2. endodontic treatment 3. teeth extraction 4. eubgingival scaling exclusion criteria: * males * females who had: 1. allergies 2. bronchial asthma 3. common cold 4. pulmonary diseases 5. migraine * females who taking: 1. antidepressants 2. anxiolytic drugs 3. opioids 4. other medications that affect emotional responses * pregnant females

Keywords: pain anxiety fear stress
protein, sarcopenic obesity, and copd

Conditions: Sarcopenic Obesity; Chronic Obstructive Pulmonary Diseases

Summary: both sarcopenic obesity and chronic obstructive pulmonary diseases (copd) are common conditions that mainly affect middle-aged and older adults. previous research has shown that increased dietary intake of total and plant-based protein is associated with a lower risk of sarcopenic obesity, using data from the epic norfolk study. furthermore, a systematic review and meta-analysis showed that having sarcopenic obesity was associated with significantly impaired lung function outcomes. other research has shown that increased intake of dietary protein leads to a better treatment outcome for respiratory diseases. the aim of this pilot observational study is to investigate, in more detail, the relationship between the quantity and source of dietary protein intake, the prevalence of sarcopenic obesity, and lung function, in a small cohort of older female participants with copd. the study will also consider the role of inflammation in relation to sarcopenic obesity and lung function outcomes. this study will help to improve the understanding of the relationship between sarcopenic obesity and lung function outcomes, and how dietary protein intake and inflammation can affect this relationship and each of the outcomes.


Eligibility criteria:
inclusion criteria: * women. * clinically diagnosed with copd. * aged 55 years or older. exclusion criteria: * male. * women who are 54 years or younger. * those who have dementia. * unable to read or write in english. * unable to attend the human intervention studies unit. * those within one year life expectancy. * those who have cancer.
the effect of intravenous prehydration on the hemodynamic status of healthy parturients undergoing spinal anesthesia for cesarean delivery

Conditions: Hypotension

Summary: regional anesthesia (spinal, epidural) is considered the method of choice for anesthesia obstetric deliveries because of the ability to use fewer drugs, a more direct experience of childbirth and the capability to provide excellent postoperative analgesia. however, the incidence of hypotension after spinal anesthesia for cesarean delivery is high and can lead to maternal and fetal morbidities. certain interventions may reduce the incidence and severity of spinal anesthesia induced hypotension, including the use of vasopressors and intravenous pre- or co-hydration using different types of volume expanders; crystalloid or colloid solutions. such interventions aim to increase maternal cardiac output, which is the key in attenuating the hypotensive response to spinal anesthesia. the primary purpose of this study is to compare the efficacy of intravenous prehydration (preloading) of healthy parturients scheduled for caesarean section with either a crystalloid (ringer's lactated) or colloid solution (hes 130/0.42) in the prevention of hypotension after spinal anesthesia. the flotrac/vigileotm device provides continuous monitoring of maternal cardiac output by employment of a minimally invasive technique based on arterial pulse contour analysis. assessment of maternal hemodynamic status using the flotrac/vigileotm constitutes a secondary outcome. other secondary outcomes are total amount of vasopressors used, neonatal outcome, intraoperative side effects and maternal satisfaction scores.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) i and ii parturients * singleton gestation * term gestation (gestational period more than 37 weeks) exclusion criteria: * extremes of weight (\ 120 kgr) * extremes of height (\ 180 cm) * baseline heart rate less than 65 bpm * active labor * known fetal abnormalities * placental abruption, placenta previa/accreta * pregnancy induced hypertension * anemia (hemoglobin \< 9 gr/dl) * cardiac, respiratory or renal disease * diabetes mellitus * spinal cord abnormalities * previous spinal surgery * preexisting neurological dysfunction * known allergy to any protocol medication * any absolute contraindication to regional anesthesia
racial differences in the coronary microcirculation

Conditions: Cardiovascular Diseases; Heart Diseases; Coronary Disease; Hypertension; Myocardial Ischemia; Hypertrophy, Left Ventricular

Summary: to study mechanisms of excess coronary ischemia secondary to alterations in autoregulation and arteriolar vasoreactivity in black americans with hypertension, varying degree of left ventricular hypertrophy, and angiographically normal or mildly diseased coronary arteries.

background: although studies in 1992 with a sufficient number of minority patients were sparse, those available suggested that black americans had a higher case fatality from coronary heart disease, but lesser amounts of atherosclerotic coronary artery disease. a possible explanation for this apparent paradox was that myocardial ischemia might be more prevalent with less coronary artery atherosclerosis in black americans because of comorbid diseases or differences in coronary physiology. this could be secondary to excess hypertension and left ventricular hypertrophy in black americans but might also have been related to intrinsic or acquired differences in coronary artery autoregulation and vasoreactivity leading to depression in coronary blood flow and reserve. design narrative: the intracoronary doppler flow velocity guidewire together with quantitative coronary angiography was used to study changes in coronary blood flow in blacks secondary to pharmacologic provocateurs known to induce arteriolar vasodilation. white americans with similar demographic characteristics and equivalent amount of ventricular hypertrophy and coronary disease were similarly studied in a parallel fashion for comparison. a control group of normal white and black americans were studied to detect unexpected intrinsic differences. both endothelium dependent and independent induction of coronary arteriolar vasodilation were studied. in 25 percent of patients with endothelium dependent defects in arteriolar vasodilation, retesting was performed after intracoronary infusion of l-arginine, the precursor of endothelium dependent relaxing factor. finally, the possibility of a rightward shift in coronary artery autoregulation in chronic hypertension was investigated. this finding would necessitate that the lower limit of autoregulation occurred at higher diastolic pressures, resulting in a drop-off of coronary perfusion at normal physiologic pressures and ischemia. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
effect of light color on stress, anxiety, and psychological well-being during nonstress test in pregnant women at risk

Conditions: Pregnant Women; Stress; Light

Summary: purpose of the research: to determine the effect of light color on stress, anxiety, and psychological well-being during the nonstress test in at-risk pregnant women. this research was planned as a single-blind randomized controlled experimental type study by comparing separate groups in the form of experiment-placebo control. data will be collected with the introductory information form, psychological well-being scale, perceived stress scale (pss/pss-14), state trait anxiety inventory (stai). the nst device is used to follow up pregnant women in the last 3 months of pregnancy, first monthly, then every two weeks and once a week. in other words, the procedure is routinely performed on every pregnant woman who comes for control. it is a device that shows the well-being of the baby and whether the mother has contractions. it is attached to the pregnant woman's abdominal area and does not cause any harm. it is not an invasive procedure. pregnant women in the last 3 months of pregnancy who come to have nst for follow-up will be randomly selected and divided into 2 groups. a lamp with adjustable light level with unit unit ut-383 mini luxmeter (light meter) will be placed in the intervention and control groups and the light level of the lamp will be adjusted to 100 lux. nst will be taken under cold (bluish white) light for the control group and under medium warm white (daylight white) light for the intervention group. pre-test before the application and post-test after the application will be applied. the application is an invasive application that will not disturb the pregnant woman.


Eligibility criteria:
inclusion criteria: * being at risk of pregnancy, * being in the last trimester of pregnancy, * being a volunteer. exclusion criteria: * having any problem that prevents communication (such as not knowing turkish, having hearing, speaking and understanding disorders), * being on psychiatric treatment (pharmacotherapy or psychotherapy), * having a disease in their eyes that prevents them from seeing