Kornimate/medical-research-clean huggingface dataset:
non-exercise physical activity intervention

Conditions: Diabete Mellitus; Aging; Cognitive Change

Summary: physical inactivity is prevalent in older adults and poses a risk factor for the development of type 2 diabetes. the aim of this pilot study was to examine the effect of non-exercise physical activity using a standing desk on clinical variables in older adults with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * older participants (65+ years) with clinically confirmed type 2 diabetes * body mass index above 25 and less than 40 kg/m2 exclusion criteria: * participants unable to perform a short clinical and motor function test battery (sabc test, mini-best)
real-world comparative effectiveness of rivaroxaban versus vka

Conditions: Atrial Fibrillation

Summary: to obtain a better understanding on the comparative effectiveness of rivaroxaban versus vka(vitamin k antagonist) for stroke prevention in patients with nvaf(non-valvular atrial fibrillation) in a real-life setting


Eligibility criteria:
inclusion criteria: * nvaf(non-valvular atrial fibrillation) will be defined as the occurrence of 2 or more inpatient or outpatient claims with icd(international classification of disease)-9 427.31 as the diagnosis code at any time in the patient's data history prior to inclusion * patients will be required to have 180 days of enrollment for the assessment of baseline characteristics * cha2ds2-vasc score ≥2 during the 180 days prior to index rivaroxaban use baseline period (cha2ds2-vasc: diabetes mellitus; s2: prior stroke or tia or thromboembolism; v: vascular disease; a: age 65-74 years; sc: sex category) exclusion criteria: * patients \<18 years of age * patients with valvular af (atrial fibrillation) * pregnancy * malignant cancers * transient cause of af * patients with venous thromboembolism (pulmonary embolism or deep vein thrombosis) * patients with major surgery defined as hip or knee replacement * prescriptions of oral anticoagulants (oacs) (apixaban, warfarin, dabigatran, rivaroxaban) before index date * prescription of more than one oac on the index date * patient with any of the events defined in the composite endpoint * fatal bleeding * fatal stroke/myocardial infarction * intracranial hemorrhage * ischemic stroke * myocardial infarction

Keywords: non-valvular atrial fibrillation (nvaf) prevention stroke
eccentric exercise versus eccentric exercise and astym for insertional achilles tendinopathy

Conditions: Insertional Achilles Tendinopathy

Summary: the purpose of this research study is to determine if astym® treatment is an effective treatment for patients with achilles pain. the usual treatment for this condition is a specific exercise program that has been previously shown to be effective. the research team is trying to determine if combining astym with the exercise program is more effective than exercise program only. the main hypothesis for this study is that astym plus eccentric exercise will be more effective than eccentric exercise alone at improving pain and function in patients with insertional achilles tendinopathy.


Eligibility criteria:
inclusion criteria: * diagnosis of insertional at as a primary complaint\* * symptom duration of at least 6 weeks * visa-a score of 78 or lower * he presence of insertional at will be clinically determined by the primary investigator using the following criteria: pain at or within 2 cm of the posterior calcaneal insertion of the achilles tendon along with localized tenderness and a subjective report of decreased activity levels secondary to achilles pain. exclusion criteria: * prior treatment with eccentric exercise or astym for achilles tendinopathy * currently taking anticoagulant medication * usage of fluoroquinolone antibiotics in the previous six months * previous achilles surgery on the involved side * bilateral symptoms * pregnancy * worker's compensation or liability cases * peripheral neuropathy * signs of lumbar radiculopathy * inability to complete the required outcomes forms or comply with the recommended treatment regimen
virtual reality distraction for reduction

Conditions: Postoperative Pain

Summary: using a randomized controlled design, the investigators goal is to estimate the effect of vr on postoperative analgesia and opioid consumption.

specifically, the investigators propose to test the primary hypothesis that the use of appliedvr software in pico g2 4k headsets decreases acute postoperative pain scores (with a 1 point difference considered clinically important) compared to sham treatment on a 0-10 scale 15 minutes after each use in the first 48 hours after surgery or hospital discharge, whichever comes first.

Eligibility criteria:
inclusion criteria: * american society of anesthesiology physical status 1-3; * scheduled for elective, primary total hip arthroplasty; * anticipated hospitalization of at least 1 night; * expected to require parenteral opioids for postoperative pain; * able to use iv pca systems. exclusion criteria: * history of chronic pain or care by a pain management specialist; * use of more than 30 mg/day of oral oxycodone (or equivalent); * greater than 12 weeks of current and continued opioid use; * history of seizures, epilepsy, motion sickness, stroke, dementia; * non-english speaking; * women who are pregnant or breastfeeding; * history of substance use disorder.
controlled release nifedipine and valsartan combination therapy in patients with essential hypertension

Conditions: Hypertension

Summary: the primary objective of this study is to investigate incremental cost effectiveness of nifedipine cr and amlodipine in combination therapy with valsartan for the treatment of essential hypertensive patients. to investigate incremental cost effectiveness, primary variables are mean treatment cost and achievement rate to target blood pressure level at the end of double-blind treatment period.


Eligibility criteria:
inclusion criteria: untreated patients or patients with previous treatment by antihypertensive agents whose blood pressure at sitting position at the time of the entry (visit 1) is: * sbp\>/=160mmhg or dbp\>/=100mmhg for untreated patients (sbp systolic blood pressure, dbp diastolic blood pressure) * sbp\>/=150mmhg or dbp\>/=95mmhg for patients with previous treatment by antihypertensive agents exclusion criteria: * patients whose blood pressure on either day of visit 1 or 2 is: sbp \> 200mmhg or dbp \> 120mmhg. * patients with secondary hypertension or hypertensive emergency such as malignant hypertension. * patients with a history of cardiovascular or cerebrovascular ischemic event (stroke, transient ischemic attack, myocardial infarction or unstable angina) within six months prior to the study. * patients with a history of intracranial or subarachnoid hemorrhage within six months prior to the study. * patients with uncontrolled diabetes (hba1c \>/=8%) * patients with bradycardia or tachycardia (\ /=100 bpm), arrhythmia such as atrioventricular block (second and third degree), sinoatrial block or atrial fibrillation.
partial weight bearing proximal femoral nail due to intertrochanteric fracture.

Conditions: Femur Intertrochanteric Fractures

Summary: femur intertrochanteric fractures (fitc) are one of the most common fractures of the lower extremity, caused by osteoporosis, caused by minor trauma in elderly patients. today, it is successfully treated with proximal femoral nails (pfn) designed in different ways. after surgical fixation with pfn, patients are mobilized by placing full weight, but some complications can be seen due to the patients being osteoporotic. in this study, the investigators planned to investigate the effect of full weight bearing and partial weight bearing on complications, which were not previously described in the literature.

participants over the age of 60 who underwent pfn with the diagnosis of fitk were randomized (double-blinded consecutive full load on one patient and partial weight on one patient), and mobilized a group with full weight with the help of a walker after surgical fixation, and the other group with the help of a walker to give partial weight (balance). we planned to follow up his treatment prospectively. the compatibility of the groups will be evaluated by comparing the bone mineral density, calcium, alkaline phosphatase, phosphate, vitamin d levels and ages of the patients. fracture types and post-treatment reduction quality of patients in both groups will be compared. we planned to compare the complication rates, barthel index and harris hip scores in the follow-up of the patients.

Eligibility criteria:
inclusion criteria: 1. patients over 65 years of age with intertrochanteric femoral fractures 2. patients treated with proximal femoral nail 3. patients able to walk before treatment 4. patients who can be contacted exclusion criteria: 1. patients without regular follow-up for 1 year 2. patients who do not walk before or after fracture 3. who have a neurological disease 4. patients with partial hip replacement after fracture 5. patients who cannot be contacted after treatment 6. patients who died within 1 year after treatment

Keywords: intertrochanteric fracture elderly fractures weight bearing
predictors of aortic root dilatation in tetralogy of fallot patients

Conditions: Congenital Heart Disease; Aortic Root Dilatation; Tetralogy of Fallot

Summary: * to predict vulnerable patients for aortic root dilatation in tof patients using ct as a reliable imaging modality, thus aiding early intervention, and identifying those who will require strict follow-up. * to assess the prevalence of tof patients who developed aortic root dilatation, and those who were complicated with dissection, ar, and aneurysm, through collecting data from a large center (aswan heart centre). * to investigate the relationship between age at repair and the diameter of aortic root.

tetralogy of fallot (tof) occurs in approximately 3 to 5 of every 10,000 live births and is the most common cyanotic congenital heart defect and it exhibits four main features. these features are pulmonary stenosis, right ventricular hypertrophy, overriding aorta and ventricular septal defect. moreover, since the survival of patients with congenital heart diseases has improved significantly in recent decades, long-term complications should be monitored cautiously. one of these complications is aortic root dilatation, attributed to increased and altered flow through the overriding aorta and an uneven sharing of conotruncal tissue between the aorta and pulmonary artery, particularly in patients who have not undergone early repair. despite the concern that tof patients may harbor aortopathy that can lead to aortic regurgitation, aortic aneurysms, and, potentially, aortic dissection, the scope of the problem remains uncertain. prevalence estimates of aortic root dilatation have ranged from 15% to 87% with the use of various criteria. moderate to severe aortic regurgitation (ar) has also been reported in up to 12.5% of adults with tof and dilated aortic roots. the incidence of aortic dissection and surgical intervention remains unknown. moreover, features associated with aortic dilatation are not fully understood. therefore, correlating and predicting vulnerable patients and identifying possible risk factors for aortic root dilatation in tof patients, will enable more cautious follow-up and earlier intervention, thus decreasing possible morbidity and mortality.

Eligibility criteria:
inclusion criteria: * all patients with tof who either underwent or have not yet had surgical correction. * all patients with fallot-type dorv. * patients should have survived until discharge and have at least one echocardiography and ct with full data related to one or more anatomic subcomponents of the aortic root, either before surgery or during follow-up, regardless of specific duration post repair. exclusion criteria: - patients who have contraindication for conducting cardiac ct scan. for instance, dye sensitivity, pregnancy, ckd, in addition to patients who have factors that interfere with ct image quality as metallic objects within the chest (e.g. pacemaker).
laser ablation in stereotactic neurosurgery (laise): neuroblate® retrospective registry

Conditions: Primary Brain Tumor

Summary: the neuroblate® system (nbs), is a minimally invasive robotic laser thermotherapy tool. it employs a pulsed surgical laser to deliver targeted energy to abnormal brain tissue caused by tumors and lesions. since receiving fda clearance in april 2013, the nbs has been used in nearly 300 procedures conducted at approximately 20 leading institutions across the united states. this post-market, multi-center retrospective study is designed to collect long-term follow-up data on patients who were treated previously with nbs.


Eligibility criteria:
inclusion criteria: * patient was previously treated with nbs * patient is willing and able to provide informed consent and authorization for release of personal health information or irb waiver is granted to collect study information without patient consent exclusion criteria: there are no exclusion criteria for this study.

Keywords: progression quality of life
efficacy and safety of cipros 20 association on dyslipidemia treatment

Conditions: Dyslipidemias

Summary: the purpose of this study is to evaluate the efficacy of cipros 20 association in the treatment of dyslipidemia treatment.


Eligibility criteria:
inclusion criteria: * participants of both sexes, aged 18 years or more; * participants with the diagnosed of dyslipidemia and with high or very high cardiovascular risk, according to the brazillian guidelines on dyslipidemia and prevention of atherosclerosis; * signed consent. exclusion criteria: * using medications that may interfere with the metabolism or serum levels of triglycerides; * any clinical and laboratory findings that, in the judgment of the investigator, may interfere with the safety of research participants; * presence of concomitant cardiovascular disease, renal failure and hepatic failure; * decompensated diabetes; * current smoking; * history hypersensitivity to the active ingredients used in the study; * pregnancy or risk of pregnancy and lactating patients; * history of alcohol abuse or illicit drug use; * participation in clinical trial in the year prior to this study.
efficacy study of a bioelectric dressing to treat wounds caused by curettage and electrodesiccation

Conditions: Wound Healing; Wound Infection

Summary: the purpose of this study is to determine whether a bioelectric wound dressing, a silver-coated dressing, or a silver-foam dressing are effective in the treatment of wounds resulting from curettage and electrodesiccation of skin lesions.


Eligibility criteria:
inclusion criteria: * if female, must either be not of childbearing potential or if they are of childbearing potential must have a negative urine pregnancy test * wound size greater than 1x1cm * wound must be ≥5 cm away from all other wounds * wound size must not be diminished in size greater than 10% between enrollment in study and the prescreening * participant agrees to participate in follow-up evaluation * participant must be able to read and understand informed consent, and sign the informed consent exclusion criteria: * concurrent participation in another clinical trial that involves an investigational drug or device that would interfere with this study * participant is to receive another topical antimicrobial agent other than the study dressing * participant with sensitivity or adverse reactions to silver or zinc * pregnancy or nursing an infant or child * immunosuppression * active or systemic infection * collagen vascular disease * diabetes * venous stasis ulcers * participant undergoing active cancer chemotherapy * chronic steroid use * decision impairment

Keywords: wound skin lesion antimicrobial bioelectric
adjustable continence therapy (act) device for the treatment of female stress urinary incontinence

Conditions: Urinary Incontinence

Summary: the purpose of this study is to evaluate the safety and effectiveness of a minimally invasive surgical procedure in up to 160 implanted female patients in which two adjustable balloons (one on each side of the urethra) are implanted to treat urinary stress incontinence. the results will be analyzed to demonstrate the effects of the device as well as its associated risks. therapeutic success will be based on whether the patients demonstrate at least a one-grade (mean) reduction in the stamey score at 12 months.

this is a multi-center, prospective, non randomized clinical trial comparing baseline data to the 12 month data. urodynamic testing, pad weights and a direct visual stress test will be used to determine success along with the stamey score.

Eligibility criteria:
inclusion criteria: * women * 18 years or older * diagnosed with stress urinary incontinence with or without urethral hypermobility * willing to sign informed consent * candidates for surgical intervention for stress incontinence * negative urinalysis or urine culture within 2 weeks of implantation * normal cystourethroscopy * failed at least 6 months of previous treatments for stress urinary incontinence (e.g., exercise regimen, electrical stimulation, surgical procedures, etc.) * may have failed suspension or sling procedures exclusion criteria: * pregnant or lactating * life expectancy of less than one year * insulin dependant diabetic * auto-immune disease * undergoing radiation therapy * active urinary tract infection * detrusor instability refractory to meds * reduced bladder compliance * significant bladder residual \>100mls * bladder cancer * unsuccessfully treated bladder stones * current urethral stricture preventing the passage of a 24 french endoscope * neurogenic bladder * uncorrected rectocele, cystocele, urethrocele, enterocele or pelvic prolapse of grade 3 or higher * prior pelvic radiotherapy * artificial urinary sphincter implanted

Keywords: urinary incontinence
assessment of fears of patients standing at the operating block

Conditions: Anxiety and Fear

Summary: the term "outpatient" refers to all the medical, organizational and administrative care that allows the patient to leave the same day the structure where the ambulatory procedure was performed. the usual rule for patients undergoing endoscopic surgery or surgery under general anesthesia is to transport them to the endoscopy or operating room lying on a stretcher, even if they can walk independently. in recent years, the procedure of bringing the patient standing in the operating room seems to have many advantages. it is readily accepted by patients and may even lessen their anxiety. nevertheless, reluctance and fears are sometimes expressed by patients who do not know this new procedure. our team has introduced this procedure for patients admitted to the ambulatory hospitalization sector and to join the endoscopy sector. the aim of our work is therefore to objectify the fears expressed by patients who have to go to the endoscopy room before general anesthesia and to evaluate their progress after endoscopy

nowadays, the procedure of the patient standing in the operating room or in endoscopy has become frequent in the outpatient management of patients. indeed the advantages are numerous: better fluidity of the patient circuits to the block, reduction of the stress of the operated one etc. yet some patients might experience fears. thus, in order to improve our practice, we want to take into account your experience with this innovative procedure. to determine patients' fears concerning their endoscopic standing before general anesthesia and to evaluate their evolution after this first experience after your installation in the preoperative area, we submit a questionnaire that corresponds to the first part of the document and then accompanied by a hospital agent you will walk towards the entrance to the endoscopy room. these questions are about your possible fears and your degree of anxiety. after an endoscopy under general anesthesia, you will be taken back to your stretcher room where you will complete the second part of the questionnaire which deals with the same topics as the questions asked before the endoscopy.

Eligibility criteria:
inclusion criteria: * to be adult (18 years minimum) * have a good understanding of the french language * a diagnosis requiring an endoscopic act. * being eligible for outpatient care during anesthesia consultation (asa i-ii and asa iii balanced, good preoperative mobility, understanding pre and postoperative instructions, ability to observe treatments, acceptable housing and hygiene conditions , access to a telephone, journey \<1h for the first night). * have never been brought before to the operating room or standing endoscopy * collection of the patient's non-opposition. exclusion criteria: * refused patient * patients with reduced mobility preoperatively * patient under tutorship or curatorship
the acupuncture for pain, opioid use disorder and mood

Conditions: Chronic Pain; Opioid Use Disorder; Mood Change; Opioid Misuse; Opioid-Related Disorders

Summary: the goal of this study is to determine how patients with chronic pain and opioid use disorder will respond to treatment with acupuncture, including whether there will be any changes in mood. results from this study have the potential to inform future studies in patients who would consider using acupuncture as an intervention for their conditions.

in this 4-week pilot study, the feasibility of recruiting a sample of participants in a modified battlefield acupuncture + national acupuncture detoxification association (bfa + nada) protocol will be assessed. utilizing a novel bfa (battlefield acupuncture) plus a nada (national acupuncture detoxification association) protocol, approximately 20 participants with chronic pain and opioid use disorder (oud), receiving methadone through an opioid treatment program (otp) at montefiore medical center, will be recruited. each participant will receive a modified bfa + nada treatment, twice per week over 4 weeks for a total of 8 treatments at the clinic. all participants will also have the small seeds placed to facilitate at-home acupressure treatment. in this feasibility study, the investigator team will collect feasibility data from each participant at every session over the course of 4 weeks. feasibility outcomes are defined in the outcome measures of this registration. as part of the study, the following will also be monitored to explore preliminary efficacy: (1) pain intensity and physical functioning, (2) opioid cravings and substance use, and (3) mood, insomnia, and stress. the research team will conduct surveys assessing pain, physical functions, the changes in stress, mood, insomnia and psychological changes at baseline, and before and after every treatment.

Eligibility criteria:
inclusion criteria: 1. ≥18 years old, 2. english proficiency; 3. receiving methadone treatment at an otp through the montefiore network for at least 12 weeks, with no dose change in 14 days to ensure treatment stability; 4. chronic pain of at least moderate pain severity (score of at least 4 on the pain, enjoyment of life and general activity (peg) scale); 5. willingness to participate in all study components; and 6. ability to provide informed consent exclusion criteria: 1. have pending surgery or invasive pain management procedure; 2. have a pending or planned relocation; 3. have an acutely or exacerbation of psychotic, suicidal, or homicidal conditions that preclude the ability to participate; and 4. pregnancy

Keywords: acupuncture