Kornimate/medical-research-clean huggingface dataset:
bowel preparation before 3d rectal water contrast transvaginal ultrasonography for rectosigmoid endometriosis

Conditions: Endometriosis, Rectum

Summary: three-dimensional (3d) rendering may be employed during transvaginal rectal water-contrast transvaginal ultrasonography (rwc-tvs) for detecting the presence and describe the characteristics of rectosigmoid endometriosis. this study aims to evaluate the impact of bowel preparation on the diagnostic parameters of 3d-rwc-tvs in women with suspicion of rectosigmoid endometriosis.

an accurate diagnosis of the presence, location and extent of the rectosigmoid endometriosis is of paramount importance for the clinicians in order to inform the patients on the potential surgical or medical treatments. it is well established that transvaginal ultrasonography is the first-line investigation in patients with suspicion of deep infiltrating endometriosis. an improvement in the performance of transvaginal ultrasonography in diagnosing rectosigmoid endometriosis may be obtained by using rectal water contrast during transvaginal ultrasonographic scan. in the last years, three-dimensional (3d) rendering has been employed during transvaginal ultrasound for benign gynecological diseases.

Eligibility criteria:
inclusion criteria: - pain and intestinal symptoms suggestive of rectosigmoid endometriosis exclusion criteria: * previous surgical diagnosis of intestinal endometriosis * previous radiological diagnosis of intestinal endometriosis (based on magnetic resonance or double-contrast barium enema * history of colorectal surgery (except appendectomy) * contraindications to bowel preparation or computed colonography (such as non-- compliant patients and rectal malformations) * previous bilateral ovariectomy * psychiatric disorders

Keywords: rectosigmoid endometriosis bowel preparation
light cured resin modified calcium silicate versus light cured calcium hydroxide in indirect pulp treatment of primary molars

Conditions: Deep Carious Lesion; Indirect Pulp Treatment

Summary: the objective of this study is to explore if light cured resin modified calcium silicate could result in better clinical and radiographic success if compared to light cured calcium hydroxide when used in indirect pulp capping treatment in primary molars.

to evaluate clinical and radiographic success of resin modified calcium silicate in comparison to light cured calcium hydroxide as indirect pulp capping materials in primary molars. p: children aged (4-7 years) with deep carious lesions in lower primary second molars indicated for indirect pulp treatment. i: indirect pulp treatment using light cured resin modified calcium silicate (theracal). c: indirect pulp treatment using light cured calcium hydroxide. o: clinical and radiographic success.

Eligibility criteria:
inclusion criteria: 1. medically free children. 2. age range from 4-7 years. 3. presence of lower second primary molars with deep carious occlusal lesion. 4. no history of spontaneous pain (reversible pulpitis). 5. clinically: absence of swelling, sinus, fistula, pain on percussion and tooth mobility. 6. radiographically: absence of radiolucent lesions at furcation or periapical region and absence of internal or external root resorption. exclusion criteria: 1. uncooperative children. 2. any unmet previous criterion.

Keywords: resin modified calcium silicate indirect pulp treatment primary molars
efficacy of extracorporeal shockwave therapy on ultrasonography changes of upper trapezius myofascial trigger points in patients with non specific neck pain

Conditions: Neck Pain

Summary: this study will be conducted to investigate the effect of extracorporeal shockwave therapy on ultrasonography changes of upper trapezius myofascial trigger points in patients with non specific neck pain

neck pain is one of the most commonly reported musculoskeletal disorders. the prevalence for neck pain varies between 16.7% and 75.1% in the general population. up to 67% of world's population may present chronic non-specific neck pain at least once in their lives. the upper trapezius is probably the muscle most often beset by trigger points, it is indicated that the upper trapezius is the most sensitive of 8 different muscles (upper trapezius, pectoralis major, levator scapulae, teres major, supraspinatus, gluteus medius, infraspinatus, paraspinal) to the pressure of an algometer.recently, the extracorporeal shock wave has been widely known to be an effective therapeutic modality in myofascial pain syndrome treatment and a systematic review provided promising insight into the effectiveness of eswt in myofascial pain syndrome treatment. sixty patients with non specific neck pain will be assigned randomly to two groups; first one will receive shock wave therapy and traditional therapy and the second one will receive traditional therapy only for six weeks.

Eligibility criteria:
inclusion criteria: * sixty patients receiving a diagnosis of non-specific neck pain with upper trapezius myofascial trigger points by an orthopaedist physician. * body mass index of participants was normal less than (30 kg/m2)(al-asadi, 2018). * age over 18 years. * presence of taught band. * presence of hyper irritable spot in a taught band, and reproduction of the typical referred pain pattern of the myofascial trigger point in response to compression exclusion criteria: * having signs and symptoms of neurological disorders that cause nerve root compression. * headache as a consequence of specific headache diagnosis. * having a history of specific signs of malignancy, or infection. * having a history of trauma with or without proven structural disorders in the region of the neck, shoulder, and head (e.g. whiplash). * having signs and symptoms of cerebrovascular insufficiency. * having a severe chronic disease of the locomotor system (e.g. polyarthritis, muscular disease * any participant with contraindications to shock wave therapy

Keywords: extracorporeal shockwave therapy ultrasonography changes non specific neck pain
potentially avoidable hospitalisation in france

Conditions: Heart Failure; COPD; Diabetes

Summary: potentially avoidable hospitalizations (pah) are studied as an indirect measure of access to primary care and of the interface between primary and secondary care. a previous work unveils considerable geographic variation in the rate of pah in france and suggest that primary care organization might play a role in this variation. however, a limitation of this work lies in the lack of data on actual primary care utilization. the aim of this study is to analyze the role of primary care in the variation of potentially avoidable hospitalizations at the zip code level, in the french region languedoc-roussillon-midi-pyrénées. the investigator will implement an ecological approach in which the geographic variation in the rate of pah is analyzed in the french region lrmp, year 2014. age- and sex-adjusted rate of pah by zip codes (n=612) is modeled using a spatial regression model.


Eligibility criteria:
inclusion criteria: * year 2014 * lrmp region * hospital admission in any public or private hospital exclusion criteria: * none

Keywords: avoidable hospitalizations primary care geographicvariation
lactoferrin versus iron supplement in irondeficiency anemia and weight loss in obese children

Conditions: Obesity, Childhood

Summary: the effect of lactoferrin versus iron supplement in treating iron deficiency anemia and helping weight loss in obese school age children

comparing iron versus lactoferrin as regard iron defiency anemia and weight loss in obese children

Eligibility criteria:
inclusion criteria: * 1. children age will be between 6 -12 years old. 2. presence of iron deficiency anemia, it will be diagnosed by * cbc \>\> hemoglobin level concentration below 11.5 g/dl. * level of serum iron is below 30 µmol/l, * level of ferritin is below 15 µg/dl * total iron binding capacity is more 480 µg/dll. 3. children should be stable and free from chronic disease. 4. body mass index (bmi) should be ≥the 95th percentile for children and teens of the same age and sex. 5. there is not history of iron supplements in the 3 months before treatment. exclusion criteria: 1. father/mother refuses to participate in the study. 2. hospitalized patient. 3. non-anemic patient. 4. patients receiving iron supplements 3 months before enrollment. 5. patients with chronic diseases. 6. personal or family history of allergy to cow's milk or infant formula, eczema, moderate-to-severe allergic rhinitis or asthma, or milk intolerance. 7. severe anemia as hemoglobin level concentration below 7 g/dl. exclusion criteria: -
pattern of admission of children with covid-19 admitted in assuit university children hospital.

Conditions: Assess the Outcome for Children With Covid-19 Admitted in Assuit University Children Hospital

Summary: a novel coronavirus was identified following a cluster of cases of pneumonia in wuhan, china, in december 2019. it rapidly spread as an outbreak there. on the 23rd of january 2020, it was announced that the outbreak constituted apublic health emergency of international concern. few weeks later, virus spread was recorded worldwide and was announcedas a pandemic by who in march 11, 2020.global spread included egypt, and the first case was recorded inegypt onfebruary 14, 2020.diagnosis of covid-19 depend on a case definition of suspected and confirmed case. implementation of case definition depend on the clinical presentation of the case and on laboratory test as well asradiological finding.the cases will be stratified according to these collective data to different grades of severity. mild cases are either asymptomatic or symptomatic with leucopenia and/or lymphopenia with no radiological evidence of pneumonia (upper respiratory tract illness ± one of the following symptoms: fever \< 38, cough,git symptoms, myalgia and/or arthralgia). moderate cases include patients with leucopenia and/or lymphopenia with clinical and radiological evidence of pneumonia, including fever \> 38 °cwith or without cough and tachypnea (respiratory rate \> 60 breaths/min forinfants \ 50 breaths/min for infants 2-12 months, \> 40 breaths/min for children 1-4 years, \> 30 breaths/min for children older than5 years old), and the condition may be associated by moderate to severe dehydration. cases are considered as severe and critically ill if any of the following is present: - o2 saturation ≤ 92% despite escalating o2 therapy to maximal allowed 6 l/min - o2 saturation ≤ 90 % at room air - if the patient in septic shock, confused or hemodynamically unstable despite fluid resuscitation - if respiratory manifestations are combined with other organ failure - chest radiography \> 50% lesion or progressive lesion within 24-48 hrs. children may play a major role in community-based viral transmission. available data suggest that children may have more upper respiratory tract involvement (including nasopharyngeal carriage) rather than lower respiratory tract involvement. the decision of the site of management either at home or in hospital depends on the clinical presentation, requirement for supportive care, potential risk factors for severe disease, and the ability of the patient to self-isolate at home. supportive treatment including sufficient fluid and calories intake, and additional oxygen supplementation should be used in the treatment of children infected with covid-19. the aim is to prevent ards, organ failure, and secondary nosocomial infections. if bacterial infection is suspected, broad-spectrum antibiotics may be used.


Eligibility criteria:
inclusion criteria: * all the patients from birth up to 18 years old admitted with suspectedor confirmed cases of covid-19 in auch. exclusion criteria: * : any patient not suspected or confirmed to have covid-19
efficacy and safety of heparin in patients with cardiovascular surgery using cardiopulmonary bypass

Conditions: Prevention of Venous Thromboembolism

Summary: the primary objective of this study is to verify, through a randomized, blinded, parallel clinical trial, the efficacy of bovine heparin from eurofarma laboratory product when compared to porcine heparin app pharmaceutical in patients undergoing surgery cardiovascular disease and who require cardiopulmonary bypass, through the control of hemostasis during and after surgery, based on measurements of markers of coagulation act, aptt, anti-xa heparin levels and the excessive blood loss (hemorrhage) after the end of surgery.


Eligibility criteria:
inclusion criteria: * patients who agree with all aspects of the study and sign the fict; * patients of both sexes; * patients over the age of 18 years; * patients with indication for cardiac surgery requiring cardiopulmonary bypass. exclusion criteria: * patients with hematological disorders that compromise the surgical outcome (eg, myeloproliferative disorders, anemia, hb \<11.0 g / dl, platelets \<100,000 mm3); * patients with disorders of hemostasis (inr\> 1.40) (apttr\> 1.40); * patients with renal impairment (creatinine\> 1.50); * patients with deep hyperthermia; * liver disease (ast and alt\> 2 times that of the reference value); * patients with a history of allergy to heparin or protamine; * patients with a history of heparin-induced thrombocytopenia; * infection (eg endocarditis, septicemia and pneumonia); * reoperations; * use of antiplatelet agents (clopidogrel and ticlopidine) for less than 7 days; * use of aspirin for less than 5 days; * use of heparin, low molecular weight less than 24 hours; * use of unfractionated heparin for less than 12 hours.
defective atypical protein kinase c (pkc) activation in diabetes and metabolic syndrome

Conditions: Diabetes Mellitus, Type 2

Summary: the investigators are examining the activation of insulin signaling factors in skeletal muscles of human diabetics. the investigators are characterizing the defects in signaling, and are examining the effects of anti-diabetic agents and exercise on signaling to glucose transport biochemical machinery and whole body glucose disposal.

we have provided clear evidence that insulin activation of all three signaling components, viz., irs-1-dependent pi 3-kinase, atypical protein kinase c (apkc) and pkb/akt is defective in diabetic muscle. these defects are best seen when insulin activation is conducted at both half-maximal and maximal stimulation. moreover, whereas previous studies had shown that treatment with metformin (met) alone improves apkc activation, or that treatment with thiazolidinedione (tzd) alone produces increases in activation of irs-1/pi3k and apkc when evaluated at maximal insulin stimulation, we have recently found that combined treatment with met plus tzd for 6 weeks provokes marked increases in insulin effects on all three signaling factors at both half-maximal and maximal insulin stimulation. this work is being prepared for submission for publication. we have also evaluated the improvement in insulin signaling in diabetic muscle 4 hours after acute endurance (one-legged) exercise and found that the responsiveness of apkc to the lipid pi3k-derived activator, pip3, was improved. also increased was the activation by insulin of irs-2-dependent pi3k, erk1/2, and downstream protein synthesis machinery, viz., p70s6 kinase and eukaryotic elongation factor eef2. these effects of exercise would be expected to enhance glucose transport and utilization by muscle, and promote protein synthesis, i.e., an anabolic response.

Eligibility criteria:
inclusion criteria: * stable uncomplicated type 2 diabetes * able to be off oral treatments for 2 months exclusion criteria: * diabetic complications related to heart, eye, nerve problems * renal impairment * cardiovascular disease * hepatic disease * prior history of other disorders or complications caused by diseases * insulin therapy needed

Keywords: diabetic
regional observatory on metabolic syndrome- lazio

Conditions: Metabolic Syndrome

Summary: the aim of the study, is to assess the prevalence of metabolic syndrome in italy on a regional basis, defined according to ncep/atpiii guidelines criteria.


Eligibility criteria:
inclusion criteria: * lipid profile in the last year * signed informed consent exclusion criteria: * subjects with serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's successful participation in the study * pregnancy or breast feeding * subject who are unwilling or unable to provide the informed consent

Keywords: metabolic syndrome lipids waist circumference
effect of cinnamon powder capsules on body composition

Conditions: Body Composition

Summary: obesity is a global health concern that significantly affects individuals, and its prevalence is still rising at an alarming rate. while various treatments are available, they often come with unwanted side effects. as a result, there is a growing interest in natural remedies including various herbs and spices such as cinnamon that have a favorable impact on overall health and disease conditions.

obesity is a global health concern that significantly affects individuals, and its prevalence is still rising at an alarming rate. pakistan is also experiencing an increasing prevalence of obesity, resulting in elevated morbidity, mortality, and healthcare costs. while various treatments are available, they often come with negative side effects that can reduce a patient's quality of life. correspondingly, natural remedies have a kindle appeal that can enhance overall health and well-being. in pakistani culture, natural condiments have been used for their health and therapeutic benefits. cinnamon, an ancient spice commonly found in various regions, contains active ingredients that offer several health benefits. however, there is limited scientific data regarding the effects of cinnamon on body composition, especially among obese university students in pakistan. therefore, the current study aims to investigate the potential outcome of orally consuming cinnamon for weight management in obese university students in pakistan. as a result, the study may provide effective evidence-based strategies for maintaining healthy body weight and exploring the potential use of cinnamon as a natural treatment option.

Eligibility criteria:
inclusion criteria: * obese individuals (≥ 25 kg/m\^2) * university students of all disciplines * participants of 18-28 years * both male and female exclusion criteria: * morbid obesity (bmi ≥30 kg/m\^2) * disease conditions (such as cardiovascular diseases, diabetes, hypertension, renal disease, hypothyroidism, and hyperthyroidism)

Keywords: obesity cinnamon body mass index body fat mass percent body fat skeletal muscle mass waist-to-hip ratio
cardiac function after minimally invasive aortic valve implantation

Conditions: Aortic Valve Stenosis; Heart Valve Diseases

Summary: this is a single-center, open-label, randomized controlled trial. patients scheduled for aortic valve replacement (avr) at karolinska university hospital in stockholm, sweden will be eligible. forty patients will be randomly assigned to either minimally invasive (20 patients) or conventional avr (20 patients). ce-marked and fda-approved mechanical and bioprosthetic aortic valves (conventional stented or sutureless bioprostheses) will be implanted. transthoracic echocardiography will be performed before surgery, and at day 1, 4, and 40. echocardiographic parameters as well as preoperative clinical characteristics and postoperative clinical outcomes will be registered. routine blood sampling will be performed pre- and postoperatively. all available data will be collected prospectively. informed consent will be obtained from patients meeting the inclusion criteria before the initiation of any study-specific procedures.


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * severe aortic stenosis defined as aortic valve area of less than 1 cm2 or index area of 0.6 cm2/m2 by echocardiography * referred for medically indicated aortic valve replacement * sinus rhythm * provide written informed consent exclusion criteria: * left ventricular ejection fraction less than 0.45 * presence of any coexisting severe valvular disorder * previous cardiac surgery * urgent or emergent surgery
early detection of pulmonary arterial hypertension using cardiac magnetic resonance imaging

Conditions: Pulmonary Hypertension; Pulmonary Arterial Hypertension

Summary: cardiac magnetic resonance imaging has emerged as a potential valuable test for the early detection of pulmonary arterial hypertension. a number of reports have provided some preliminary evidence that pulmonary artery (pa) stiffness may be accurately detected by imaging of the pulmonary artery in order to measure pa stiffness. in addition, cardiac mri could play provide early and effective treatment for pulmonary arterial hypertension (pah).


Eligibility criteria:
inclusion criteria: consecutive patients aged ≥ 18 years with pah as dictated by a comprehensive examination and echocardiography will be included for enrollment. exclusion criteria: * age \< 18 years * pregnancy * mechanical ventilation * acute or chronic renal failure (creatinine clearance \< 30 ml/min or requiring renal replacement therapy) * inability to perform mri (i.e. claustrophobia, severe obesity (\> 150 kg), device incompatible with mri) * significant arrhythmia that precludes adequate ecg-gating for the mri (i.e. atrial fibrillation with highly variable cycle lengths) * prior heart or lung transplantation * left ventricular systolic (ejection fraction \< 50%) or diastolic failure (based on framingham criteria for heart failure with preserved ejection fraction) * significant left-sided valvular disease (≥ moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation) or prior valve surgery

Keywords: pulsatility normal subjects mild pulmonary hypertension exercise-associated pulmonary hypertension