Kornimate/medical-research-clean huggingface dataset:
intrauterine balloon tamponade in the management of postpartum hemorrhage

Conditions: Postpartum Hemorrhage

Summary: intrauterine balloon tamponade in the management of postpartum hemorrhage in the obstetrics emergency ward in menoufiya university hospitals as a low resource setting.guidelines for the management of postpartum hemorrhage involve a stepwise approach including the exclusion of retained products and genital tract trauma. uterine atony, which is the most common cause, is dealt with uterine rubbing and various uterotonic agents. among the new modalities introduced to arrest the bleeding is the uterine tamponade using various balloons and catheters. the condom catheter uses a sterile rubber catheter fitted with a condom for uterine tamponade .

objectives: to evaluate the outcome of uterine balloon tamponade using condom-catheter in the management of primary postpartum hemorrhage (pph). material and methods: prospective observational study included 50 women with primary postpartum hemorrhage unresponsive to uterotonics and bimanual compression, was conducted at the department of obstetrics \&gynecology, menoufia university hospital, egypt. clinical assessment, laboratory investigations and intrauterine condom catheter were applied to all patients. the primary outcome was the success of the balloon to stop bleeding, maternal complications were assessed as secondary outcomes.

Eligibility criteria:
inclusion criteria: * women with primary postpartum hemorrhage ( defined as \>500 ml estimated blood loss after vaginal delivery or \>1000 ml after cesarean delivery)in the first 24 h , unresponsive to uterotonics and bimanual compression were enrolled exclusion criteria: * patients with traumatic pph, retained placenta, coagulopathy and severe systemic diseases were excluded from the study

Keywords: postpartum hemorrhage uterine tamponade condom catheter
binocular custom vision utilizing the light adjustable lens (lal)

Conditions: Cataract; Pseudophakia

Summary: the objective of this investigator initiated study (iit-001) is to obtain data on clinical methods which can be used during the examination of patients desiring binocular custom vision with the light adjustable lens (lal). an analysis of the collected data will be performed to determine whether these clinical assessments can be used by doctors to enhance their patient's clinical outcome.


Eligibility criteria:
inclusion criteria: 1. patients able to sign informed consent 2. patients who plan to undergo bilateral implantation with the commercial lal and receive binocular custom vision are eligible for study participation. exclusion criteria: * inability to sign informed consent * any pathology for which, in the investigator's judgement, could reduce the subjects bcva * unable to return for light treatments
bariatric surgery and covid-19

Conditions: COVID-19; Bariatric Surgery Candidate

Summary: the national bariatric surgical registry (nbsr) is a prospectively collected database for all patients undergoing elective bariatric surgery in the uk. it was used to identify patients that underwent elective bariatric surgery during the pandemic (one year from 1st april 2020). characteristics of this group were compared with a pre-pandemic cohort (one year from 1st september 2018).


Eligibility criteria:
inclusion criteria: all patients listed on national bariatric surgical registry (nbsr) that underwent elective bariatric surgery during the pandemic (one year from 1st april 2020) or prior to the pandemic (one year from 1st september 2018) - exclusion criteria: - where a variable was 'not recorded' this point was excluded from analysis. for age, gender, procedure type and provider the records were 100% complete, for bmi at time of surgery there was 5% missing data and for other variables the missing value rate was 2% or lower.
a study of mk0364 in obese patients (0364-014)

Conditions: Obesity

Summary: a worldwide study in obese patients to assess the efficacy, safety, and tolerability of an investigational drug.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) between 30-43 kg/m2 exclusion criteria: * history of major psychiatric disorder * history of seizures or at high risk of developing seizures * blood pressure greater than 160/100 * fasting blood glucose greater than 126 mg/dl * triglycerides greater than 600 mg/dl
lunglb in subjects presenting with indeterminate pulmonary nodules

Conditions: Solitary Pulmonary Nodule; Multiple Pulmonary Nodules

Summary: correlate performance of lunglb test with outcome of a scheduled biopsy.


Eligibility criteria:
inclusion criteria: 1. at least 18 years old with a ct identified indeterminate pulmonary nodule and scheduled for biopsy, at the time of consent. 2. planned biopsy nodule of interest: 1. is solid ≤3 cm; or 2. is nonsolid, ground glass opacity, of any size; or 3. is part solid, where the solid component is no larger than 3cm (maximum diameter). exclusion criteria: 1. current and or prior diagnosis +/- treatment of non-lung cancer within the past 3 years. 2. current and or prior lung cancer diagnosis within 2 years following intent-to-cure surgery.

Keywords: lung cancer circulating genetically abnormal cells (cgac) 4-color fish increased/decreased risk early lung cancer detection indeterminate nodule
sentra am® and sentra pm® for post-traumatic stress disorder (ptsd) and gulf war fibromyalgia (gwf)

Conditions: Post-traumatic Stress Disorder; Persian Gulf Syndrome

Summary: an open-label clinical outcomes study to determine the safety and efficacy of sentra am® and sentra pm® for post-traumatic stress disorder (ptsd) and gulf war fibromyalgia (gwf).

male and female military veterans age 18 to 75 experiencing moderate to severe ptsd symptoms including cognitive dysfunction, sleep disorders and mood disorders. open-label internet questionnaire-based clinical outcomes study. 250 subjects. 60 days from enrollment initiation to completion and study close. sentra am- two capsules given orally once daily in the morning for 30 days. sentra pm- two capsules given orally once daily thirty minutes before bedtime for 30 days. to measure improvement in quality of life determined by the change in short form-36 (sf-36) general health survey. improvements in daytime sleepiness determined by the epworth sleepiness scale (ess), improvement in cognitive and emotional function using the cognitive emotion regulation questionnaire - short (cerq-short), change in ptsd symptoms with the primary care - ptsd (pc-ptsd), psychopathy checklist- military (pcl-m). heart rate variability (hrv) data variation will be measured in a group of twenty subjects.

Eligibility criteria:
inclusion criteria: 1. united states military veterans reporting ptsd and/or gulf war illness symptoms at least three months after return from duty. 2. men and non-pregnant, non-lactating women over the age of 18 and under the age of 75, able to read and understand english-language informed consent. 3. men and women of child-bearing potential willing to use adequate contraception, not to become pregnant or impregnate their partner for the study duration. 4. patients who will continue on a stable dose (no less than three months) of other medications they are taking and maintain the same dose throughout the duration of the study. 5. patients willing to commit to completing all clinical questionnaires and guidelines during study-related procedures. exclusion criteria: 1. patients who have previously taken sentra am or sentra pm. 2. patients not fluent in english. 3. participation in a clinical trial within one (1) month prior to screening. 4. uncontrolled or unstable serious cardiovascular, pulmonary, gastrointestinal, endocrine or neurologic disorder.

Keywords: ptsd military veteran gulf war fibromyalgia gulf war syndrome
diagnostic study of rapid regadenoson stress cardiovascular magnetic resonance (cmr) to detect coronary artery disease

Conditions: Coronary Artery Disease

Summary: this study is designed to evaluate the feasibility and diagnostic performance of a novel rapid regadenoson stress cmr protocol for detecting of obstructive coronary artery disease.

this is a single center, open-label, pilot study in subjects scheduled for invasive coronary angiography for evaluation of coronary artery disease. the primary objective is to evaluate the profile of sensitivity, specificity, and diagnostic accuracy of a novel rapid regadenoson stress cmr protocol for detection of \>= 70 coronary artery stenosis on invasive coronary angiography. additionally the objective will be to compare the time for performance of this novel rapid regadenoson stress cmr protocol in comparison to the standard stress cmr protocol.

Eligibility criteria:
inclusion criteria: * aged 18 years or older * scheduled for invasive coronary angiography exclusion criteria: * inability to give informed consent * possible pregnancy (confirmed by urine test) * women who are breastfeeding * severe claustrophobia * inability to lie flat for 20-30 minutes (the anticipated amount of time to complete the mri procedure) * individuals with cochlear implants * individuals with non-mri compatible aneurysm clips * potential contraindications to regadenoson use due to: severe lung disease (active wheezing) severe bradycardia (heart rate \< 40 beats/min) second- or third-degree atrioventricular heart block sick sinus syndrome history of long qt syndrome severe hypotension (systolic bp \< 80 mm hg) decompensated heart failure * contraindication to administration of gadolinium (gd) based contrast agents (gbca): stage 4 or 5 chronic kidney disease (egfr \< 30 ml/min/1.73 m2) known allergy to gbca special considerations: - although individuals who have an occupational history of welding, grinding, or other metal work will not be excluded from the study, they must undergo an orbital x-ray, to exclude any occult metal fragments, before they can participate in this study.

Keywords: coronary artery disease
serratus intercostal plane block,new analgesia in supraumbilical surgery

Conditions: Postoperative Pain; Analgesia; Local Anaesthetic; Abdominal Injury

Summary: background: the surgeries with upper abdominal wall incisions cause a severe pain and providing an adequate analgesia is an important challenge for the anesthesiologist. the serratus intercostal plane block (sipb) has been already described as analgesic technique in open cholecystectomy. the aim of this study is to evaluate its analgesic efficacy in pain control, opioids consumption and recovery quality in upper abdominal surgeries. methods: this blind, randomized controlled study was conducted on 102 patients undergoing open upper abdominal wall surgery under general anesthesia. all patients who received serratus intercostal plane block at the eighth rib as analgesic technique were included in group 0 (sipb) and in group 1 (control) those who received continuous intravenous morphine analgesia. in each group was evaluated pain scores in numeric verbal scale (nvs) and opioids consumption at 0,6,12,24 y 48h postoperative time. the quality of the postoperative recovery was evaluated with the modified postoperative quality of recovery score ( qor-15 questionnaire) at 24h.

the scientific evidence always supports the employment of a multimodal analgesic strategy, especially in procedures that generate a severe postoperative pain2, as media laparotomy or subcostal incision. the purpose is to not retard the patients' recovery and to avoid complications. the thoracic epidural analgesia is still the reference analgesic technique in open abdominal surgery7, although it is not exempt of limitations and complications. that is why, since the introduction of thoracic and abdominal fascial blocks, they have been part of the analgesic strategy, being an alternative to considerer instead the epidural.

Eligibility criteria:
inclusion criteria: * informed consent signature * patients \>18 years old, . american society of anesthesiologist (asa) risk scale \< iv, * supraumbilical laparotomy (elective laparotomy or laparoscopy conversion) exclusion criteria: * neurologic impairment, * inability to give informed consent, * used drugs allergy, * contraindications to nerve block (coagulopathy, local infection at the site of the block) * chronic pain treatment.

Keywords: analgesia abdominal surgery
aripiprazole in body focused repetitive behaviors

Conditions: Trichotillomania (Hair-Pulling Disorder); Dermatillomania

Summary: this study is 6 weeks long and involves subjects taking aripiprazole or placebo. if they are randomly assigned to the aripiprazole arm and are eligible to participate in the study, they will begin by taking 5mg once daily of aripiprazole for two weeks, then 10mg once daily for the remaining three weeks. efficacy and safety measures will be performed at each visit. participants will be randomized to receive either aripiprazole or placebo on a 1:1 basis. this blinding will be maintained by the ids pharmacy at the university of chicago.

the goal of the proposed study is to evaluate the efficacy and safety of aripiprazole in 100 subjects with dsm-5 trichotillomania (ttm) or skin picking disorder (spd). the hypothesis to be tested is that aripiprazole will be effective and well tolerated in patients with bfrbs (trichotillomania or skin picking disorder) compared to placebo. the proposed study will provide needed data on the treatment of disabling disorders that currently lack a clearly effective treatment. this will be one of few studies assessing the use of pharmacotherapy for the treatment of ttm and spd in adults. assessing the efficacy and safety of aripiprazole will help inform clinicians about additional treatment options for adults suffering from this disorder.

Eligibility criteria:
inclusion criteria: 1. men and women age ≥18 years 2. current dsm-5 trichotillomania or skin picking disorder; and 3. ability to understand and sign the consent form. exclusion criteria: 1. unstable medical illness based on history or clinically significant abnormalities on baseline physical examination 2. current pregnancy or lactation, or inadequate contraception in women of childbearing potential 3. subjects considered an immediate suicide risk based on the columbia suicide severity rating scale (c-ssrs) (www.cssrs.columbia.edu/docs) 4. past 12-month dsm-5 diagnosis of psychosis, bipolar disorder, mania, or a substance or alcohol use disorder 5. illegal substance use based on urine toxicology screening 6. stable dose of medications for at least the past 3 months 7. previous treatment with aripiprazole 8. cognitive impairment that interferes with the capacity to understand and self-administer medication or provide written informed consent
multi-center clean air randomized controlled trial in copd

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: this is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing copd exacerbation risk and improving quality of life, functional status, rescue medication use.

the multi-center clean air randomized controlled trial in copd (clean air) is a multi-center, prospective, randomized, double-blind, sham-controlled trial that will enroll 770 former smokers with copd over a 4-year period and follow participants at regular intervals for one year. the primary endpoint is respiratory specific quality of life. secondary endpoints include rate of acute exacerbations, rescue medication use, quality of life, and cost-effectiveness.

Eligibility criteria:
inclusion criteria to be eligible, subjects must meet all these criteria: 1. age ≥ 40 years. 2. self-report of physician diagnosis of copd. 3. spirometry confirmed airway obstruction (post-bronchodilator spirometry of forced expiratory volume in 1 second (fev1)/forced vital capacity (fvc) \< 0.7) as defined by the global initiative for obstructive lung disease (gold) criteria (6, 11) 4. tobacco exposure ≥ 10 pack-years. this refers to regular cigarette tobacco consumption. 5. self-reported former smoker of at least 6 months' duration. this does not include e-cigarette use. 6. copd assessment test (cat) score ≥ 10, modified medical research council dyspnea scale (mmrc) ≥ 2, or history of moderate or severe exacerbation in the past 12 months (as defined by history of receiving a course of systemic corticosteroids or antibiotics for respiratory problems; or visiting an emergency department or being hospitalized for a copd exacerbation within the past 12 months.) exclusion criteria to be eligible, subjects must not meet any one of these criteria: 1. living in a location other than home (e.g., long-term care facility, nursing home) 2. other chronic lung diseases, except asthma 3. condition with less than a year of life expectancy (e.g., metastatic cancer) or in hospice 4. spends \>2 months per year in location other than home; or plans to change residence in the next 12 months 5. pregnant or breastfeeding 6. current air cleaner use in the home 7. inability to bring air cleaners (about 15 pounds each) into home, either by self, friend, or relative 8. deemed by the study investigator to be unable to complete study protocol, including likely lack of internet connectivity 9. participating in another interventional clinical trial

Keywords: air cleaner indoor air quality quality of life rescue medication use
3d printed personalized extendable prosthesis

Conditions: Osteosarcoma in Children

Summary: the goal of this type of observational study is to investigate the preliminary effect of 3d printed personalized extendable prosthesis replacement on limb salvage in children with osteosarcoma. the main question it aims to answer is: is 3d printed personalized extendable prosthesis replacement has a good outcome in limb salvage pediatric osteosarcoma？

osteosarcoma is one of the most common primary malignant bone tumors in children and adolescents. in this study, the investigators try to investigate the preliminary effect of 3d printed personalized extendable prosthesis replacement on limb salvage in children with osteosarcoma.

Eligibility criteria:
inclusion criteria: * tumors of the extremities, with moderate soft-tissue invasion * the neurovascular bundle is not invaded, and the tumor can be excised totally * no metastatic lesions or metastases can be cured exclusion criteria: * recurrent tumors * poorly differentiated tumors * poor soft-tissue conditions * neurovascular invasion around tumors * ineffective chemotherapy with metastasis
the effect of the nursing intervention program on adolescent problematic internet users

Conditions: Internet Addiction Disorder

Summary: in this study; the effect of the nursing intervention program (education enriched with web 2.0 tools based on the health belief model) on problematic internet use, loneliness and family harmony in adolescents who use the internet with problems will be determined.

in this study; the effect of the nursing intervention program (education enriched with web 2.0 tools based on the health belief model) on problematic internet use, loneliness and family harmony in adolescents who use the internet with problems will be determined. this research is a cross-sectional randomized controlled experimental study with a cross-sectional type in the first stage and a pretest-posttest in the second stage.

Eligibility criteria:
inclusion criteria: 1. being a secondary school student, 2. agreeing to participate in the research, 3. being open to communication and cooperation, 4. can use web 2.0 tools via smartphone or computer exclusion criteria: - having a score of less than 50 points and above 79 points on the internet addiction scale.

Keywords: family cohesion scale internet addiction scale loneliness scale for children
the biosonographic index

Conditions: Acute Kidney Injury

Summary: in this exploratory study we explore the use of shear wave elastography to differentiate between acute kidney injury after vascular surgery and among the healthy population.


Eligibility criteria:
inclusion criteria: * no history of diabetes or hypertension * estimated glomerular filtration rate \> 60 ml/min/m\^2 * structurally normal kidney on renal ultrasound * bmi \< 27 kg/m\^2 exclusion criteria: * prisoners directly admitted from a correctional facility * children \< 19 years or under 50 kg body weight if age is unknown * patients with end stage renal disease or preexisting glomerular filtration rate less than or equal to 30 ml/min/1.73 m\^2 or need for dialysis * patients with end stage heart disease on the cardiac transplant list * patients undergoing procedures without vascular surgery * all transplant patients * patients on ventricular assist devices * patients undergoing emergency procedures * patients with body mass index \> 27kg/m\^2 * any condition that would impede visualization of the kidneys by ultrasound
effects of diet versus diet plus aerobic and resistant exercise program in overweight women

Conditions: Overweight; Exercise

Summary: adult women aged 18-50 years and overweight (preobese) with a bmi of 25-30 kg/m2 will be included in the study. participants will participate in an eight-week diet and diet plus aerobic and resistance exercise program. patients will be referred from the nutrition and diet polyclinic of bezmialem vakıf university to this study, which will be conducted to investigate the effects of exercise program on postural control, musculoskeletal system disorders, functional capacity, and sleep.

subjects who accepted to participate in the study will be randomized and divided into two groups as study and control groups. a computer-based randomization program (random.org) will be used to determine the cases to be assigned to the study and control groups. 2 numbers consisting of 12 numbers will be determined by random selection from the numbers between 1 and 24. the first of these number sequences will be considered as the study group and the second as the control group. each patient included in the study will be asked to draw one of the sealed envelopes in which the numbers 1 to 24 are written. the case will be assigned to the study or control group according to the number sequence in which the drawn number is included. while the women in the study group are expected to perform regular walking with a diet for eight weeks and a 3-day aerobic and resistance exercise program per week, the subjects in the control group will be followed up with diet and regular walking. initially, participants will be educated on healthy eating habits through one-on-one dietitian consultation. a personalized calorie-restricting nutrition program will be given. according to this program, the daily energy intake of the individual will be reduced to provide 0.5-1.0 kg of body weight loss per week.

Eligibility criteria:
inclusion criteria: * bmi between 25-29.9kg/m2 * being between the ages of 18-50 * agreeing to participate voluntarily in the study exclusion criteria: * pregnancy * presence of systemic disease that will prevent participation in an aerobic exercise program * presence of conditions such as pain or surgery that will prevent participation in an aerobic exercise program * participating in a regular exercise program within the last 1 year

Keywords: overweight aerobic and resistance exercise postural control musculoskeletal disorders functional capacity sleep