Kornimate/medical-research-clean huggingface dataset:
transition of t1dm patients aged over 65 years into ahcl (780g) insulin pump

Conditions: Diabetes Type 1

Summary: older people with diabetes have a higher risk for cognitive impairment and for physical disability whether this may be effected by an improvement in glucose indices is unknown. thus, the aim of this study is to assess the efficacy of ahcl in people with type 1 diabetes in improving glucose indices, quality of life and physical capacity indices

recent advances in insulin pumps, continuous glucose monitoring (cgm) devices, and control algorithms have resulted in an acceleration of progress in the development of the automated systems of insulin delivery including advanced hybrid closed loop (hcl) insulin pumps. the results of the ahcl insulin pump based studies published so far are very encouraging, including that medtronic-sponsored study performed at our center "transition of csii/cgm naïve patients directly into ahcl (780g) insulin pump: the impact on glucose patterns and quality of life measures" (1-6). unfortunately there is little data concerning the usage of ahcl systems in older patients. the management of these individuals is particularly challenging as older adults with type 1 diabetes are especially vulnerable to hypoglycaemia. the recent ada/easd consensus underlines that the use of advanced technologies in older individuals is useful and should not be discontinued or a priori excluded because of the older age (7). since the ahcl systems are very effective in hypoglycemia prevention they could be considered the treatment of choice in older patients with t1dm. the open question is how effectively would older individuals adopt this advanced technology, how would they accept it, and if the simplicity in terms of everyday usage of ahcl versus less advanced technologies would be appreciated by older individuals with t1dm. older people with diabetes have a higher risk for cognitive impairment and for physical disability whether this may be effected by an improvement in glucose indices is unknown. thus, the aim of this study is to assess the efficacy of ahcl in people with type 1 diabetes in improving glucose indices, quality of life and physical capacity indices

Eligibility criteria:
inclusion criteria: 1. age over 65 years 2. t1dm 3. willing to participate in a study for the specified duration 4. willing to perform ≥ 4 finger stick blood glucose measurements daily 5. willing to wear the system continuously throughout the study 6. glycosylated hemoglobin (a1c) value less than 10.0% at time of screening visit 7. treated with mdi/csii (with exclusion of 780g) 8. willing to perform at least 4 bgm/day, when on mdi/csii 9. lack of advanced complications of diabetes, egfr\>30 exclusion criteria: 1. severe concurrent illness 2. laboratory abnormalities, or medications that might affect study participation, 3. severe renal impairment (egfr\<30)

Keywords: ahcl insulin pump therapy multiple daily injection qol
biological bank for the patients followed in a constitutive reference center for autoimmune cytopenia

Conditions: Immune Thrombocytopenia; Autoimmune Hemolytic Anemia; Autoimmune Neutropenia

Summary: the internal medicine department of haut-lévêque hospital (pr e lazaro, pr jl pellegrin, pr jf viallard) was accredited in 2017 by the ministry of health as a constitutive reference center for autoimmune cytopenia. the investigators wish to launch new research projects in autoimmune cytopenia and propose a translational and fundamental research based on collaboration between the clinical department, the biological resource center and the cnrs and inserm research units ("bedside to the bench strategy"). thus, in the perspective of future research work, it seems imperative to set up a biological bank for the patients followed in our reference center.

our department follows about 350 patients with immune thrombocytopenia (itp), 50 with autoimmune hemolytic anemia (aha), and about thirty patients for autoimmune neutropenia and erythroblastopenia. the number of new patients per year is about 50. the investigators are working since several years on different research topics concerning itp and aha. in the field of itp, the investigators are working on abnormalities of megakaryopoiesis present in a particular subgroup of patients. the investigators seek to identify the molecular mechanisms underlying this platelet-forming disorder. this research is done within the inserm u1034 unit of the university of bordeaux. in aha, the investigators are working on the role of regulatory cd8+ t lymphocytes and the interest of low doses of interleukin-2 in their treatment. this part is carried out within the cnrs unit umr 5164 immunoconcept. the biological collection the investigators wish to create will be available for basic research projects and may be available to the pharmaceutical industry as part of the development of new molecules.

Eligibility criteria:
inclusion criteria: * patients over 16 years old. * patients with autoimmune cytopenia according to the definitions reported in the latest update of the french national care protocol (pnds 2017). * affiliated person or beneficiary of a social security scheme. * free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research). exclusion criteria: * positivity for hiv, hepatitis c or b virus. * pregnant or lactating woman. * patient undergoing treatment for autoimmune cytopenia

Keywords: biological collection
a decision support system based on classification algorithms for the diagnosis of periodontal disease

Conditions: Periodontal Diseases

Summary: the study purposes for periodontal applications, such as diagnosing gingivitis and periodontal disease, artificial intelligence (ai) models have been developed; however, their accuracy and technological maturity are to be evolved. the applications of such technologies in the field of periodontics are walking baby steps worldwide. the kingdom of saudi arabia is moving fast in technology adoption and implementation in different sectors. however, the healthcare sector, especially clinical-related, needs original research applied to saudi subjects. the literature in the field of machine learning applications in dentistry is limited. although ai models for periodontology applications are still being developed, they could serve as potent diagnostic instruments. the current study was planned to add to the current gap in the literature.

a cross-sectional study design will be applied. two hundred fifty patients will be evaluated by an experienced periodontist and used as input variables. the final diagnosis output will be generated by considering relevant information from the patient's medical history, clinical dental examination, and radiographic exam. of the sample of 250 patients, 20% of the participants will be assigned randomly to the test group, while the rest will be assigned to the training group before feeding it to the algorithms. the study purposes for periodontal applications, such as diagnosing gingivitis and periodontal disease, artificial intelligence (ai) models have been developed; however, their accuracy and technological maturity are to be evolved. the applications of such technologies in the field of periodontics are walking baby steps worldwide. the kingdom of saudi arabia is moving fast in technology adoption and implementation in different sectors. however, the healthcare sector, especially clinical-related, needs original research applied to saudi subjects. the literature in the field of machine learning applications in dentistry is limited. although ai models for periodontology applications are still being developed, they could serve as potent diagnostic instruments. the current study was planned to add to the current gap in the literature.

Eligibility criteria:
inclusion criteria: * age 18 or more * no periodontal treatment has been done at least 6 months prior to the enrollment * seeking periodontal treatment exclusion criteria: * refuse to volunteer in the study

Keywords: periodontal disease diagnosis machine learning saudi
positioning of surgical patients with sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: the study aims to evaluate the effect of non-supine positioning in the treatment of surgical patients with obstructive sleep apnea. the hypothesis is that non-supine positioning will result in a decrease in acute hypoxic events, defined as the number of apneas/hypopneas per hour of sleep.

this is a prospective, randomized controlled trial that will comprise of two stages. stage 1 is a pilot study of 30 patients at high risk or diagnosed with obstructive sleep apnea who are scheduled for routine surgery. these patients will be randomized 1:1:1 to standard of care (0 degree bed angle), 30 degree bed angle, or 60 degree bed angle. acute hypoxic events will be analyzed pre and post-op in the randomly assigned bed position. pacu nurses will also be surveyed for patient-favored non-supine positioning (30 vs. 60 degrees). stage 2 will be a larger, powered trial to evaluate the efficacy of just one bed angle (30 or 60 degrees) based on the stage 1 results.

Eligibility criteria:
inclusion criteria: * minimum 1 night postoperative hospital stay * more than 18 and less than 80 years old * identified as high risk of osa (sacs \> 15) or a history of osa without cpap treatment exclusion criteria: * unwilling or unable to give informed consent * undergoing nasal, eye, head/neck surgery, intracranial or cardiac/thoracic surgery * currently undergoing treatment for sleep apnea including cpap * requiring prolonged postoperative ventilation * nyha functional class iii and iv * valvular heart disease, dilated cardiomyopathy, implanted cardiac pacemaker, or unstable angina * myocardial infarction or cardiac surgery within 3 months * chronic obstructive pulmonary disease, or asthma * presence of tracheostomy, facial, neck, or chest wall abnormalities * abdominal aortic aneurysm surgery, chemotherapy, or immunosuppressive therapy within 3 months * visiting preoperative clinic less than 3 days before surgery * requiring postoperative nasogastric tube
reliability of khq and iciq-sf in assessing urinary incontinence effects in polish women

Conditions: Urinary Incontinence; Overactive Bladder; Stress Urinary Incontinence; Urge Incontinence

Summary: the aim of this study was to assess the psychometric properties of khq and iciq-sf in polish women.

purpose the king's health questionnaire (khq) and the international consultation on incontinence modular questionnaire (iciq-sf) short form are widely used in clinical practice. the aim of this study was to assess the psychometric properties of khq and iciq-sf in polish women. methods one hundred fifty-five women with urinary incontinence (ui) aged between 19-82 years underwent urodynamic investigation and completed both khq and iciq-sf. to evaluate the factor structure and construct the validity of the khq and iciq, principal component analysis (pca) using varimax rotation was conducted for all questionnaire items. pca results were also confirmed by spearman's correlations between khq and iciq items. moreover, the internal consistency of the khq and iciq was estimated by way of cronbach's alpha coefficient (α). statistical analysis was performed using statistica version 13.1 software (statsoft, poland), as well as open source r software (version 3.4.4).

Eligibility criteria:
inclusion criteria: * informed consent * patients with symptoms of urinary incontinence * age 18-82 years exclusion criteria: * lack of consent * inability to understand the study protocol

Keywords: king's health questionnaire the international consultation on incontinence modular questionnaire (iciq-sf) short form
outcomes and trauma pattern in penetrating neck injuries

Conditions: Neck Injuries

Summary: it is an observational retrospective multicenter study

it is an observational descriptive, retrospective study. the study will be conducted in two centers: the emergency and accident unit and head and neck surgical unit manchester royal infirmary, manchester, united kingdom and trauma unit and otolaryngology department assiut university hospital, assiut, egypt. the study will include all the patients presented to both centers with open neck trauma in duration between april 2018 and october 2020. the following items recorded: gender, age, type of trauma (whether it is homicidal, suicidal, accidental trauma), time of the day the patients presented, previous philological disorder in patients with suicidal types of trauma, number of neck wounds, site of the wounds ( in relation to the zones of the neck), size of each wound in centimeter, whether the wounds are deep or superficial to platysma, length of stay in the hospital, , injuries to any neck structures injuries in other parts of the body, involvement of other teams in management of the patent and type of involvement. also the need of airway support (either intubation or tracheostomy), immediate and long term complications of the injury and if the patients needed neck exploration or just suturing of the wounds under local anesthesia. data of the patients who needed exploration will be reviewed to detect finding in neck exploration and try to find out the criteria of the patients who needed neck exploration and put a clear protocol for management. the included patients will be categorized into 3 groups according to type of trauma (suicidal, homicidal or accidental) all the recorded data will be compared to detect the outcomes in each type of trauma and if there is a specific pattern of trauma in each category. the study will be conducted after obtaining an institutional review board (irb) approval from the committee of medical ethics, faculty of medicine, assiut university. the study and all interventions and surgical procedures within it were done by scientifically qualified and trained personnel. the is no additional risk for participating in the study as it is a descriptive study

Eligibility criteria:
inclusion criteria: 1) all age groups regardless of sex. 2) homicidal, suicidal and accidental type of trauma. 3) patients with penetrating neck injuries due to sharp objects trauma. 4) poly trauma patients having multiple body trauma as well as neck trauma will be included. b. exclusion criteria: 1. patients with blunt neck trauma even if causing open wounds 2. patients with neck burns 3. patients with previous neck surgeries
transcranial doppler and quantitative pupillometry as neurological prognostic factors in brain damaged patients admitted to intensive care unit

Conditions: Brain Damage

Summary: transcranial doppler is performed daily in intensive care unit in brain damaged patients. for a few years now, the measurement of the photomotor reflex by quantitative pupillometry has been routinely performed in intensive care units. the objective of this work is to see if transcranial doppler recorded parameters and pupillary parameters are correlated to the neurological prognosis evaluated at 9 months by the modified rankin score (mrs) and the glasgow outcome scale extended (gos-e).


Eligibility criteria:
inclusion criteria: * all brain damaged patients (stroke or head trauma) * admitted to intensive care unit since december 1, 2020 exclusion criteria: * refusal by the patient or his/her legal representative. * benefiting from legal protection

Keywords: brain injury transcranial doppler quantitative pupillometry, neurological prognosis modified rankin score (mrs) glasgow outcome scale extended (gos-e)
different surgical techniques for pterygium surgery

Conditions: Pterygium

Summary: a study to research the post-operative results according to the chosen surgical technique and evaluate the refractive changes before and after the excision of pterygium.

to analyze the epidemiological profile of patients who were operated of pterygium in eyes institute of goiânia, analyze the post-operative results according to the chosen surgical technique and evaluate the refractive changes before and after the excision of pterygium.

Eligibility criteria:
inclusion criteria: * patients who were underwent the pterygium surgery during the period between from february 2013 to august 2013 exclusion criteria: * patients with mature cataract

Keywords: pterygium surgery refractive changes surgical technique
treating adolescents with cbt and obh

Conditions: Anxiety Disorders; Depressive Disorder; Substance Use Disorders

Summary: the purpose of this study is to examine various behavioral, social, and emotional changes that result from engaging in an obh and cbt treatment program designed for adolescents.

after being informed about the study and potential risks, all study participants, including minors and parent/guardians, giving written informed consent will complete a screening survey. the screening survey will support research staff in determining whether participants meet the inclusionary and exclusionary data, including meeting scores on the youth outcome questionnaire and the revised children's anxiety and depression scale. if participants are eligible based on preliminary criteria, they undergo a screening interview. if participants are eligible following the screening interview and complete a second informed consent, minors and parents/guardians, they will be randomized in a partially-blind, parallel-group study conducted in the united states (7 outdoor behavioral healthcare programs and up to 42 cbt-licensed therapists).

Eligibility criteria:
inclusion criteria: * between the ages of 13 and 17 years of age * 5th grade reading level * for minors, informed assent * parental informed consent and adult consent to participate in the study * current diagnosis of depression and/or anxiety per parent report, parental interview, and score of 65 on the rcads. youth with comorbid diagnoses of these listed diagnoses are eligible * current secondary diagnosis of substance use disorder (optional) * score greater than a 47 on the yoq-2.0 * willingness to participate in all aspects of the treatment programs * has the ability to carry a pack that is 1⁄4 their body weight exclusion criteria: * primary diagnosis of substance use disorder * antisocial personality * level 2 or higher autism spectrum * schizophrenia * actively suicidal * eating disorders * bmi greater than 34 * diabetic * physical ailments or disabilities limiting person from hiking, camping, backpacking * specific medications including anxiolytics/benzodiazepines, opiates, or multiple antipsychotics and mood stabilizers * youth who have a positive pregnancy test * participation in another treatment or intervention study within one year of beginning the study * individuals currently suffering from detoxification as a result of drug use in the last five days. if drug use occurs during this time period, the participant must wait until they have achieved five days of substance free behavior. this is done to prevent contraindications of treatment (e.g., interaction between drugs and the environment) * currently practicing violent behaviors to self or others within the past year per parent report * currently experiencing hallucinations (hearing voices or seeing things that are not there)
safety and efficacy of oral fampridine-sustained release (sr) for the treatment of spasticity resulting from spinal cord injury

Conditions: Spinal Cord Injury; Muscle Spasticity

Summary: normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the arms and legs. in people with spinal cord injury, some fibers may be destroyed at the site of injury, while others remain connected but do not work correctly to carry electrical impulses. as a result, subjects with an incomplete spinal cord injury may have spasticity which is muscle spasms or muscle stiffness that makes movement difficult. fampridine-sr is an experimental drug that increases the ability of the nerve to conduct electrical impulses. this study will examine the effects of fampridine-sr on moderate to severe lower-limb spasticity, as well as the effects on bodily functions such as bladder control, bowel function and sexual function. the study will also examine the possible risks of taking fampridine-sr.


Eligibility criteria:
inclusion criteria: * incomplete traumatic spinal cord injury (at least 18 months prior and stable for 6 months) * moderate to severe lower-limb spasticity * able to give informed consent and willing to comply with protocol exclusion criteria: * pregnancy * history of seizures * existing or history of frequent urinary tract infections * history of drug or alcohol abuse * allergy to pyridine-containing substances * received a botox injection 4 months prior to study * received an investigational drug within 30 days * previously treated with 4-aminopyridine (4-ap) * not on stable medication dosing in 3 weeks prior to study * abnormal ecg or laboratory value at screening

Keywords: spinal cord injury muscle spasticity
social media and covid19 pandemic

Conditions: Social Media; Corona Virus Infection

Summary: according to the data of february 2020, in turkey with a population of 83.9 million, internet and social media usage percentage to population are 74% and 64% respectively. although previous researches have investigated the effect of social media on different medical situations, there is no study focused role of social media on patients' behavior and information source during the covid-19 pandemic. in the present study, it is aimed to reveal the impact of social media on patients' attitudes and information sources during the covid-19 pandemic.

the coronavirus disease (covid-19) outbreak was first diagnosed in late december 2019 in wuhan at china's hubei province. after four months, coronavirus infection has spread to 6 continents and 185 countries, with a dramatic increase of almost 3 million people have been infected and more than 200,000 people died.jhm as a result of the pandemic, the closure of borders, social isolation, and the crushing of health systems under an excessive load, peoples search different ways to achieve proper information regarding protecting themselves from this disaster including government announcements, hospitals, private doctors, and social media. according to the data of february 2020, in turkey with a population of 83.9 million, internet and social media usage percentage to population are 74% and 64% respectively. social media is the most frequently translated way of informing due to its quick, cheap, and easy access potential. although previous researches have investigated the effect of social media on different medical situations, there is no study focused role of social media on patients' behavior and information source during the covid-19 pandemic. in the present study, it is aimed to reveal the impact of social media on patients' attitudes and information sources during the covid-19 pandemic.

Eligibility criteria:
inclusion criteria: * older than 18 yo * no diagnosis with any psychologic disease * with literacy exclusion criteria: * younger than 18 yo * inability to complete the form * not giving consent to participate in the study