Kornimate/medical-research-clean huggingface dataset:
conventional laparoscopic sleeve gastrectomy versus endograb-assisted single-port sleeve gastrectomy

Conditions: Morbid Obesity

Summary: bariatric surgery has been established as the best treatment for morbid obesity, compared with diet or medical treatment. laparoscopic approach have improved the results of this surgery in terms of postoperative pain, reduction in the number of complications and hospital stay, as well as better cosmetic results. conventional laparoscopic technique requires five to seven abdominal incisions to facilitate placement of the multiple trocars. new single incision laparoscopic surgery (sils)has been developed as a new technique where only one incision is needed for the introduction of all trocars. altough this technique can be performed with conventional laparoscopic instruments, new devides have been developed for facilitate this operations by sils. the investigators think that reducing the number of incision would decrease the postoperative pain and improve cosmetic results in our patients, being a safe and technically feasible intervention supported by these special devices.


Eligibility criteria:
inclusion criteria: * body mass index \> 40 * body mass index \> 35 with 2 mayor comorbidities exclusion criteria: * severe gastroesophageal reflux * esophagitis grade b or higher * midline periumbilical incision * umbilical hernia \>4cms.
evaluation of biomechanical forced during the practice of endoscopic submucosal dissection

Conditions: Endoscopic Submucosal Dissection; Physiology; Musculoskeletal Disorders

Summary: the prevalence of musculoskeletal disorders (msds) among endoscopists is estimated between 29 and 89%. the most common disorders are carpal tunnel syndrome, de quervain tenosynovitis, lateral epicondylitis and neck pain. factors associated with msd among gastroenterologists practicing endoscopy are: the high number of procedures (more than 20/week), the procedure time (more than 16 hours/week) and the number of years of practice.with the evolution of digestive endoscopy superficial cancer can endoscopically be removed by endoscopic submucosal dissection (esd) avoiding surgical resections. the number of procedures is increasing, with longer examination times in case of esd (about 2 hours). this volume of hours and procedures may in the near future further increase the risk of msds in the population of gastroenterologists. some good practice recommendations have been proposed to improve practitioner comfort, similar to what is recommended for digestive surgeons. it is recommended to use a height-adjustable examination table, position the screen at eye level, and use a seat during the procedure. there is little data on the biomechanical forced experienced by an endoscopist when performing endoscopy and colonoscopy, and none when performing esd. the aim of this study is to evaluate the biomechanical forced experienced by the gastroenterologist during an esd the practice of submucosal dissection.


Eligibility criteria:
inclusion criteria: * adult subject (age ≥ 18 years) * hepato-gastroenterologist * hepato-gastroenterologist performing endoscopic submucosal dissection * person who has given consent for participation in the study exclusion criteria: * non hepato-gastroenterologist * person who has not given consent for participation in the study

Keywords: endoscopic submucosal dissection biomechanic physiology musculoskeletal disorders
graft patency as a predictor of health-related quality of life.

Conditions: Ischemic Heart Disease; Atherosclerosis

Summary: the health-related quality of life questionnaire "eq-5d" has been collected in connection with several interventional and observational studies where the no-touch vein harvesting technique in cabg has been used. the results of the questionnaires will be compiled and reported in this study.


Eligibility criteria:
inclusion criteria: 1. operated at our department for a coronary artery bypass surgery with either the no-touch harvesting technique of conventional harvesting technique. 2. completed the eq-5d questionnaire. 3. signed and dated consent. exclusion criteria: 1. substantial missing data from the eq-5d questionnaire. 2. unable to comprehend the different inquiries in the questionnaire.

Keywords: coronary artery bypass grafting saphenous vein no-touch technique
ckd-11101 phase 3 iv study in patients who had renal anemia receiving hemodialysis

Conditions: Anemia of Chronic Kidney Disease

Summary: the aim of this study was to compare and evaluate efficacy and safety of intravenous ckd-11101 versus darbepoetin alfa in patients who have renal anemia receiving hemodialysis.

this study was designed as randomized, double-blind, multi-center, phase 3 clinical study to evaluate the efficacy and safety of intravenous ckd-11101 versus darbepoetin alfa in patients who had renal anemia receiving hemodialysis. the selection criteria are evaluated for 19-year-old patients who receive stable hemodialysis treatment for 3 months or more in patients with chronic renal failure. after completion of the stabilization period of 12 to 16 weeks for darbepoetin alfa, the subjects with the mean hb levels of 10 to 12g/dl measured during the baseline visit and 0 week visit are randomized to the test and control groups in a 1:1 ratio during the randomization visit. they have a 20-week maintenance period and a 4-week evaluation period.

Eligibility criteria:
* inclusion criteria 1. patients with 19 years of age or older 2. patients with anemia in chronic renal failure 3. patients who started hemodialysis more than 3 months ago and receive appropriate hemodialysis, satisfying the following criterion: -kt/v is ≥ 1.2 or urea reduction ratio is ≥ 65% 4. patients with the mean hb levels of 10 to 12g/dl measured at the baseline and randomization visits 5. patients with enough body iron stores who meet the following item: -serum ferritin ≥ 100ng/ml or transferrin saturation ≥ 20% 6. patients who have provided written consent to participate in the trial voluntarily * exclusion criteria 1. patients with uncontrolled hypertension 2. patients who had hypersensitivity to erythropoietin agents 3. patients who had known hypersensitivity to mammalian cell-derived products or diluting agents 4. patients with history of severe cardiovascular diseases 5. patients who have received red blood cell transfusion or hormone therapy for anemia correction within 12 weeks prior to randomization 6. patients whose anemia is not caused by chronic renal failure or may affect anemia correction 7. patients whose ast/alt test results performed at screening exceed twice of normal upper limit 8. patients who had experience of positive result in anti-erythropoietin antibody in previous treatment with erythropoiesis stimulating agent 9. patients who have been planned to change the dialysis method
combining primary and secondary prevention for reduction of excessive weight gain in school

Conditions: Obesity

Summary: the main objective is to evaluate the effects of a multicomponent, school-based intervention combining change in nutritional behaviors with after school physical activity activities in reducing the excessive weight gain in schoolchildren.

specific objectives are: - evaluate the effect of the program on: change in nutritional behaviors, such as reducing sugar sweetened beverages and cookies intake reduction of time spent in sedentary activities gains in school performance and cognition outcomes the amount of daily physical activity on the percentage of body fat, changes in biochemical markers and blood pressure.

Eligibility criteria:
inclusion criteria: both prevention programs: * 6th and 7th grades students * consent form signed by parents / tutors secondary prevention program: - overweight and obese children exclusion criteria: * pregnant girls

Keywords: school-based intervention after school physical activity sugar sweetened beverages sedentary behavior schoolchildren
the effect of online training on foot care

Conditions: Type2diabetes; Diabetic Foot

Summary: the aim of this study is to determine the effect of online trainings on diabetic foot care on foot care behavior and self-efficacy attitudes of individuals with type ii diabetes. purpose in accordance with the patient's diagnostic information form, diabetic foot care self-efficacy scale(daboo), foot care behavior scale(abdo) and diabetic foot risk screening forms are available in the data collection tools; education and research hospital internal medicine outpatient clinic with deeply izmit seka state hospital, inpatient or outpatient treatment for persons with type ii diabetes who agree to volunteer to participate in research 90 shall apply. after that, the groups will be divided into two groups by randomization, and one of the groups will be given training sessions consisting of min 20 max 40 minutes for diabetic foot care in 5 sessions for nine weeks. after the training, the scales will be applied to the groups again. the data obtained before and after the training will be compared statistically in a computer environment


Eligibility criteria:
inclusion criteria: * patients who were applied the dietetic foot risk screening form during the physician's examination and who were in the low and medium risk groups after the physician's examination. * to be able to read and write. * being between the ages of 18-65. * being on oral antidiabetic (oad) and/or insulin therapy. * no restriction of access to the internet. * to be able to use the zoom program or whatsapp video conversation with or without support. * having computer and/or telephone skills. * volunteering to participate in the study (informed consent form will be signed by the participants during the application) * not having sensory loss such as speech and hearing that prevents communication and no psychiatric problems. exclusion criteria: outside the inclusion criteria.

Keywords: type2diabetes diabeticfootcare onlineeducational distanceeducation self-effectıveness
self-management in stroke survivors

Conditions: Stroke; Hypertension

Summary: this is a feasibility study of using health-it to promote self-management of risk factors in stroke survivors.


Eligibility criteria:
inclusion criteria: * acute stroke survivors and their caregivers * english speaking * history of hypertension exclusion criteria: -cannot use the health-it system
ims® diareg diabetes registry - prospective diabetes registry of patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: this observation plan outlines the approach to build a diabetes registry to collect data on daily routine of treatment of type 2 diabetes mellitus.

the choice to establish such a (general and specific) disease patient registry was based on several scientific and practical considerations as described in the ahrq user's guide: registries for evaluating patient outcomes (www.ahrq.gov, 2007). from a public health point of view, such a register should monitor naturalistic (i.e., unbiased) use of diabetes treatment in the community and should primarily guide and assist medical professionals to make optimal choices in combating diabetes. the primary focus of this registry is therefore to monitor the medical and lifestyle treatment of diabetes in order to enable comparison of different treatment options and to provide data for future discussions of optimal treatment.

Eligibility criteria:
inclusion criteria: * provision of signed written informed consent * age of 18 years or older * diagnosis of type 2 diabetes mellitus (t2dm) exclusion criteria: only patients who don't fulfill the inclusion criteria will be excluded. there will be no further possibility for the treating physician to exclude individual patients.

Keywords: type 2 diabetes mellitus
effectiveness of family group interventions for people with schizophrenia

Conditions: Schizophrenia

Summary: the mutual support group intervention would significantly improve the families' burden of care, functioning and social support, reduce the patients' severity of symptoms and re-hospitalizations, and reduce the demands for utilization of family services, when compared with the standard care group.

family interventions in schizophrenia have shown positive effects on patients but little attention has been paid to their effects on family members, particularly those in non-western countries. this multi-site randomized controlled trial evaluated the effectiveness of a bi-weekly, 12-session, family-led mutual support group for chinese caregivers of schizophrenia sufferers over 36 months, compared with a family psychoeducation group program and standard psychiatric care. it was conducted with 114 families of outpatients with schizophrenia in hong kong of whom 38 were assigned randomly to a mutual support group, a psychoeducation group, or standard care. families' psychosocial health status and patients' symptom severity and length of re-hospitalizations at recruitment, one-month, 18-month, and 36-month post-intervention were compared between groups.

Eligibility criteria:
inclusion criteria: * family caregivers lived with and cared for one family member diagnosed with schizophrenia according to the criteria of the diagnostic and statistical manual of mental disorders, 4th edition (dsm-iv; american psychiatric association, 1994) * family caregivers were at least 18 years of age and could understand and read the chinese (mandarin) language; and * family caregivers were free from any mental illness themselves. exclusion criteria: * the patients with schizophrenia suffered no co-morbidity due to other mental illness during recruitment to the study * family caregivers cared for more than one family member with mental or chronic physical illness; and/or * family caregivers had been the primary carers for less than three months

Keywords: mutual support group psychoeducation group family caregivers schizophrenia
national polish registry of minimally invasive liver surgery

Conditions: Liver Tumor

Summary: after the two consensus meetings on laparoscopic liver resection in louisville (2008) and in morioka (2014) minimally invasive approach for liver resection was finally widely established in liver surgery practice. successively more countries follow laparoscopic liver pioneers and apply laparoscopic liver surgery for everyday practice. primary aim of the study is to assess the evolution and diffusion of minimally invasive liver surgery in poland. secondly, it will allow to assess the actual short- and long-term results of laparoscopic liver resections and compare it to the international benchmark values. the national polish registry of minimally invasive liver surgery will include data about all cases of laparoscopic liver resections performed in poland since the first case in 2010. all surgical departments, where laparoscopic liverresection is regularly performed, will be invited. data of demography, previous medical history, preoperative assessment, intraoperative and postoperative period, histopathological findings and long-term follow-up will be included in the registry. this study will be the first national report about diffusion of minimally invasive surgery in poland.


Eligibility criteria:
inclusion criteria: * age \>18 years * underwent laparoscopic liver resection

Keywords: laparoscopic liver resection short-term results long-term results
triage now: an observational, prospective multimarker study of biomarkers in patients presenting with chest pain

Conditions: Acute Coronary Syndrome; Myocardial Infarction

Summary: study of diagnostic tests for heart attack for patients with chest pain.

study of multiple biomarkers, including myeloperoxidase, in the evaluation of patients presenting with suspected acute coronary syndrome.

Eligibility criteria:
inclusion criteria: * chest pain and acs in differential diagnosis * age\> 18 years * ability to give informed consent exclusion criteria: * trauma * vulnerable populations * known inflammatory condition

Keywords: acs nstemi myeloperoxidase nonst segment elevation myocardial infarction
prevalence of inpatient hyperglycemia: risks, complications and outcomes

Conditions: Diabetes Mellitus; Diabetes Complications

Summary: this protocol will determine the prevalence of hyperglycemia and diabetes in the elective orthopedic population at the university of wisconsin. it will also determine if there is a difference in outcomes. the study hypothesizes that at least 10% of patients will have some degree of impaired glucose regulation that has previously been undiagnosed.


Eligibility criteria:
inclusion criteria: * ages 18 years or older * undergoing elective total knee, hip or lumbar spinal surgery exclusion criteria: * pregnancy * unable to give consent
ergocalciferol in chronic kidney disease

Conditions: Chronic Kidney Disease

Summary: to examine the effect of ergocalciferol treatment on 25-hydroxyvitamin d and pth levels in patients with ckd stage 3 and 4


Eligibility criteria:
inclusion criteria: * patient with ckd stage 3 or 4 whose 25-hydroxyvitamin d levels are below 30 ng/ml and plasma intact pth levels \>70 pg/ml. exclusion criteria: * patients who are on any form of active vitamin treatment

Keywords: ergocalciferol chronic kidney disease secondary hyperparathyroidism vitamin d deficiency
oxytocin infusions and blood loss in patients undergoing elective cesarean delivery.

Conditions: Postpartum Hemorrhage

Summary: although prior dose-finding studies have investigated the optimal bolus dose of oxytocin to initiate adequate uterine tone, it is unclear what oxytocin infusion regimen is required to maintain adequate uterine tone after delivery. the study investigators aim to compare two different infusion rates of oxytocin to assess the optimal infusion regimen for reducing blood loss in women undergoing elective cesarean delivery.

oxytocin (pitocin) is a drug commonly used in obstetric practice, and the drug effect is to increase the muscular tone of the uterus to reduce uterine bleeding after neonatal delivery. pregnant patients undergoing elective (scheduled)cesarean delivery routinely receive oxytocin after delivery of the baby. post-delivery, oxytocin is commonly administered as an iv bolus and/or infusion. no previous studies have accurately assessed differences in oxytocin infusions after delivery in patients undergoing elective cesarean delivery. thus the study aim is to investigate which infusion rate can optimally provide adequate maintenance of uterine tone during cesarean delivery while being associated with minimal or no maternal side-effects.

Eligibility criteria:
inclusion criteria: * healthy pregnant patients with uncomplicated pregnancies: * asa (american association of anesthesiologists) class 1 or 2 patients. * singleton pregnancies. exclusion criteria: * asa class 3 or 4 patients. * known drug allergy to intravenous oxytocin. * significant medical or obstetric disease. * known uterine abnormality. * known placental abnormality.

Keywords: oxytocin blood loss cesarean delivery
clinical and biological digestive peritoneal carcinomatosis data base from the french national network of peritoneal surface malignancies

Conditions: Digestive Peritoneal Carcinomatosis

Summary: to access to good quality biological samples is a prerequisite for high level translational research. the big-renape study has been established by the french hyperthermic intraperitoneal chemotherapy centers involved in the management of peritoneal surface malignancies. the main big-renape study aim is to create a large multicentric and prospective repository for biological and tissue samples, which will provide a source of materials for a wide array of health related research studies - big-renape biobank-based research: i) validating known and promising biomarkers; ii) identifying new predictive and prognostic factors; iii) evaluating the impact of current health care strategies; iv) standardizing diagnostic and therapeutic management through guidelines; v) developing new drugs. the big-renape biobank is certified according to nfs 96-900 as a service of processing, storage and transfer of high quality biological (plasma, serum, buffy coat) and tissue (formalin-fixed-paraffin-embedded) samples. biospecimens are collected at each stage of diagnostic and therapeutic care. the patient and his derivates are anonymized and registered in a national web database reporting disease status, treatments, surgical procedures, pathological diagnosis, quality of life's assessment and long term follow-up. all participants have given their informed consent before any sample. the big-renape study was approved by the local ethical committee, based on the assessed compliance to french regulatory rules.


Eligibility criteria:
inclusion criteria: * men / women aged over 18 years * patients with cancer management and care for peritoneal carcinomatosis of digestive origin * patients had histologic/radiologic confirmation of peritoneal disease * covered by a health system where applicable, and/or in compliance with the recommendations of the national laws in force relating to biomedical research; * ability of participants to give their informed consent exclusion criteria: * minor patient * adult unable to consent * patient refusal to participate in the study

Keywords: peritoneal carcinomatosis biobanking biospecimen research prospective clinical database tissue banking quality of life various histological subtypes
rapid, minimally-invasive voluntary adult male circumcision

Conditions: Circumcision

Summary: this study will evaluate a new, minimally-invasive surgical circumcision technique for men, which is easy to learn and perform, is safe, and is associated with high patient satisfaction and excellent cosmetic results.

voluntary medical male circumcision (vmmc) is a priority preventive intervention for hiv transmission. currently, the most widely used vmmc technique in south africa is open surgical circumcision. according to the framework for clinical evaluation of devices for adult male circumcision (who, 2011): "who and other health authorities wish to identify one or more devices that (a) would make the vmmc safer, easier, and quicker; (b) would have more rapid healing than current methods and/or might entail less risk of hiv transmission in the post-operative period; (c) could be performed safely by health-care providers with a minimal level of training; and (d) would be cost-effective compared to standard surgical methods for male circumcision scale up." this quasi-experimental compares the open surgical technique to an alternative minimally-invasive technique using the disposable unicirc device with tissue adhesive. the controls come from a separate randomized controlled trial (unicirc 001) that was conducted just prior to the unicirc 002 case series of 50 subjects. the investigators postulate that vmmc using the unicirc device meets who criteria for the ideal method to scale up: it is an easier technique to learn and perform, requires less intraoperative time, is safer for both surgeons and patients, heals quicker, and is more cost effective than other currently available techniques. the disposable nature of the device is an immense advantage as it eliminates the need to sterilize and can therefore be used in resource-limited settings. it also reduces the chances of infection caused by contaminated instruments.

Eligibility criteria:
inclusion criteria: healthy men at least 18 years of age requesting circumcision no anatomical penile abnormalities or infections able to provide informed consent to participate willing to participate in follow-up visits - exclusion criteria: current illness penile abnormality or infection which contraindicates or would complicate circumcision history of bleeding disorder past reaction to local anesthetic -

Keywords: circumcision voluntary medical male circumcision minimally-invasive hiv prevention