Kornimate/medical-research-clean huggingface dataset:
apneic oxygénation by nasal canula during infants airway management study

Conditions: Infant Apnea; Surgical Procedure, Unspecified; Airway Management

Summary: this is a randomized clinical trial investigating the utility of apneic oxygenation via high flow nasal cannulae during airway management for infants general anaesthesia. three groups will be compared, a control group at 0 l/min, a 0,2l/kg/min and a 1l/kg/min group. the primary outcome will be the time (in seconds) between onset of apnea and one of theses end-points : desaturation (spo2 \<95%) or airway management completed.

airway management can be a life saving therapy. one major complication that may occur during airway management is a lack of oxygen in the blood, especially in peadiatric population, due to anatomical and physiological considerations. if severe or prolonged, this lack of oxygen can result in permanent brain damage, damage to other vital organs or even death. pre-oxygenation prior to induction of anaesthesia is standard practice to prevent desaturation and hypoxemia. apnoeic oxygenation in adults is effective and prolongs the time to desaturation. apneic oxygenation is a novel method of delivering oxygen to a patient despite a lack of active respiration (i.e. the patient is not breathing on their own and the investigators are not providing the patient an artificial breath). the simplest and least invasive method to provide apneic oxygenation is the application of oxygen through nasal cannula during airway management. the effectiveness of apnoeic oxygenation in the adult is well document, especially in bariatric population or icu, however only few study are interesting about pediatric population. recent studies suggest that high flow is similar to low flow oxygenotherapy. therefore, the aim of this study was to investigate the effectiveness of apnoeic oxygenation during airway management in infants. this is a randomized clinical trial investigating the utility of apneic oxygenation via high flow nasal cannula during airway management for infant's general anesthesia. three groups will be compared, a control group at 0 l/min, a 0,2l/kg/min and a 1l/kg/min group. the primary outcome will be the time (in seconds) between onset of apnea and one of these end-points : desaturation (spo2 \<95%) or airway management completed. all infants included will receive french actual standard of care concerning general anesthesia and peri-operative medicine.

Eligibility criteria:
inclusion criteria: * infants between 0 (post-conceptionnal age \>41 weeks post amenorrhea) and 24 months of life * scheduled for elective surgery under general anesthesia * need of orotracheal intubation by direct laryngoscopy or video-laryngoscopy exclusion criteria: * emergency surgery * crush induction needed * high clinical risk of difficult airway management * premature before 1 month of life

Keywords: apnoeic oxygenation airway management oxygen insufflation paediatric general anaesthesia
effect of xylitol on oral microbiota in children

Conditions: Bacterial Infections

Summary: 1. the present controlled, randomized, doubleblind study aims to answer the following questions: * how will the "normal flora" be affected by the xylitol consumption? * will daily consumption of xylitol change the plaque-saliva distribution of the mutans streptococci? * the association of the test results will also be compared with the caries status at the baseline. 2. about eighty subjects with ms counts of log cfu 5 or more will be identified and invited to the study. they will be randomly divided into a xylitol and sorbitol group. 3. xylitol/sorbitol gum (6g polyol/day) will be used for 5 weeks. saliva samples will be collected before and after gum use. 4. studying and quantifying of 16 bacterial species belonging to the normal flora by dna-dna hybridizations and real-time pcr will show how xylitol influenced the oral flora in general.

xylitol, a 5-carbon polyol, has in clinical studies prevented caries occurrence in children and decreased counts of mutans streptococci (ms) and the amount of plaque when used on daily basis. how xylitol influences mutans streptococci is far from clear. also the effects of xylitol on the normal flora are poorly understood. the present controlled, randomized, doubleblind study aims to answer the following questions: 1. how will the "normal flora" be affected by the xylitol consumption? 2. will daily consumption of xylitol change the plaque-saliva distribution of the mutans streptococci? 3. the association of the test results will also be compared with the caries status at the baseline. after collecting informed consent forms from the parents, about 177 children will be screened for the presence of salivary mutans streptococci (sm) with chairside test, dentocult sm® strip mutans (orion diagnostica, finland). sorbitol is regarded as an inert polyol. xylitol/sorbitol gum (6g polyol/day) will be used for 5 weeks. saliva samples will be collected before and after gum use. studying and quantifying of 16 bacterial species belonging to the normal flora by dna-dna hybridizations and real-time pcr will show how xylitol influenced the oral flora in general. comparison of ms counts in unstimulated vs. stimulated saliva will show how xylitol affected the adhesivity of the ms.

Eligibility criteria:
inclusion criteria: * high sm count exclusion criteria: * low sm count, * ongoing medication

Keywords: oral microbiota mutans streptococci xylitol
safety and efficacy of changing to duotrav in patients uncontrolled on timolol

Conditions: Glaucoma

Summary: the purpose of this study was to assess the safety and intraocular pressure (iop)-lowering efficacy of changing to duotrav® from prior timolol 0.5% monotherapy in participants with open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ocular hypertension, primary open-angle glaucoma or pigmentary glaucoma; * intraocular pressure (iop) of between 19 to 35 mmhg at any time of the day in at least one eye (designated as the study eye); * on a stable medication regimen for iop reduction one week prior to the screening visit; * best corrected visual acuity better than 20/200 (snellen) or 1.0 (logmar) in each eye; * sign informed consent; * other protocol-defined inclusion criteria may apply. exclusion criteria: * known medical history of allergy, hypersensitivity or low tolerance to any of the components of duotrav®; * any abnormality that would preclude the reliable performance of applanation tonometry in either eye; * infection in either eye; * conventional or laser intraocular surgery in either eye 3 months prior to screening visit; * risk for visual field or visual acuity worsening, in the opinion of the investigator; * women of childbearing potential; * pregnant or lactating women; * any condition that, in the opinion of the principal investigator, could interfere with participation in the study, or that could present a risk to the participant. * participation in another clinical study within 30 days before the screening visit; * other protocol-defined exclusion criteria may apply.

Keywords: primary open-angle glaucoma ocular hypertension pigment dispersion glaucoma iop
a substantial equivalence study of rd04723 and predicate device

Conditions: Hypertrophic Scar; Keloid Scar

Summary: the purpose of this study is to determine whether a developmental formulation is substantially equivalent to the predicate device in the treatment of hypertrophic and keloid scars.


Eligibility criteria:
inclusion criteria: * ability to provide informed consent and release health information * ability to follow study instructions and study requirements * have a hypertrophic or keloid scar accessible for treatment and evaluation * negative pregnancy test for women of childbearing potential * agreement to use effective birth control method for study duration exclusion criteria: * history of allergy or sensitivity to components * history of diabetes * history of collagen vascular disorders * anticipated need for surgery or hospitalization during the study * pregnant, nursing, or planning a pregnancy during the study * current enrollment in an investigational drug or device study or participation in such a study within the last 30 days prior to baseline (day 0)
vegan and omnivorous diets and skeletal muscle turnover in healthy older adults

Conditions: Healthy Aging

Summary: dietary protein intake and physical activity are key to minimise the age-related loss of skeletal muscle mass. while animal-derived protein sources are considered high-quality anabolic foods, it remains unclear whether non-animal-derived (vegan) protein sources support skeletal muscle maintenance and healthy ageing. the aim of the present study is to assess the effect of a vegan diet on daily muscle protein synthesis rates compared to a protein-matched omnivorous diet where the majority of protein is derived from high-quality animal-based protein sources.

background: the age-related loss of muscle mass and strength is (partly) explained by a blunted responsiveness of skeletal muscle to the anabolic properties of dietary protein and muscle contraction. therefore, sufficient dietary protein intake and physical activity are required to minimise age-related muscle atrophy. it remains unknown whether this can be achieved utilising non-animal-derived (vegan) protein sources. objective: to assess daily muscle protein synthesis rates when adopting a vegan or protein-matched omnivorous control diet. methods: healthy older adults (aged 60-80 years) will be randomly allocated to a completely controlled 1-week vegan (providing 0.8 g/kg bw/day protein) or protein-matched omnivorous diet. during this week, participants will perform a set of unilateral leg resistance exercise on day 1, 3, and 5. deuterium oxide in combination with saliva and muscle sample (from the m. vastus lateralis) collection will be used to measure daily muscle protein synthesis rates in resting and exercised tissue. value: this will be the first study assessing daily muscle protein turnover in healthy older adults adopting a 1-week vegan diet. this will contribute to the understanding and viability of vegan protein to support active and healthy ageing.

Eligibility criteria:
inclusion criteria: * bmi between 18.5 - 30 * active (not very sedentary and not master athlete; assessed via ipaq) * women only: post menopause exclusion criteria: * hypertension (\>150/90 mmhg) * any diagnosed metabolic impairment * any diagnosed cardiovascular disease * any diagnosed gastrointestinal disease * diagnosed cancer * any medication known to affect muscle metabolism (e.g. hormone replacement therapy) * severe food allergies or intolerances (e.g. celiac, lactose intolerance, allergic to fungi or algae foods) * smoking

Keywords: muscle metabolism protein metabolism sarcopenia resistance exercise
decipher genomics resource for intelligent discovery

Conditions: Prostate Cancer; Bladder Cancer; Renal Cancer

Summary: to prospectively evaluate the utility of genomic expression data as a tool to better characterize the tumors of individual patients, and to understand how genomic information from individual patients undergoing routine clinical testing can be used in population-level analysis to improve treatment and outcomes.

observational study involving the release of tumor genome-wide expression data generated by the decipher assay which will be linked to clinical treatment and outcome data for patients in whom decipher clinical testing was performed. the grid database population will be used to characterize the genomics of cancer and discover or validate gene expression signatures that may be useful for understanding of the biology of the disease and implementing precision medicine approaches for cancer patients.

Eligibility criteria:
inclusion criteria: subjects that have had a decipher clinical test

Keywords: decipher transcriptome gene expression
the effect of strain-counterstrain on ankle instability

Conditions: Other Instability, Ankle and Foot

Summary: this study seeks to determine the effectiveness of strain counterstrain in the treatment of chronic ankle instability.

this study aimed to determine the effect of strain counterstrain (scs) on dynamic balance and subjective sense of instability in individuals with chronic ankle instability (cai). although many studies have been published on cai, the cause for this common clinical dysfunction remains inconclusive. no studies have assessed the effectiveness of scs on cai. baseline information on all participants includes a demographic questionnaire, the star excursion balance test (sebt), and the foot and ankle ability measure (faam). participants were randomized into the scs intervention group or the sham scs control group. all participants received an intervention (as assigned) once a week for four weeks in addition to performing a prescribed home exercise program. at week four all participants repeated the outcome measures and completed a global rating of change (groc) form. the primary aim was examined with a 2-way analysis of variance (anova).

Eligibility criteria:
inclusion criteria: * history of at least 1 ankle sprain, with pain and/or limping for more than 1 day, at least 3 months earlier * 3 of more episodes of ankle giving way in the last 12 months * chronic instability attributed to the original sprain injury * age between 18-55 exclusion criteria: * history of fracture or surgery in the affected ankle * any other lower extremity musculoskeletal injury on the side of the involved ankle * vestibular dysfunction or disorder * history of balance dysfunction * history of stroke or any other neurological pathology or disease * history of acl injury * current participation in physical therapy or rehabilitation for the ankle injury * evidence of cns dysfunction

Keywords: chronic ankle instability lateral ankle sprain manual therapy star excursion balance test strain and counterstrain
occlusal bite force changes after placement of stainless steel crowns in children

Conditions: Dental Caries

Summary: the aim of this study was to determine if restoring primary molars with sscs would improve children's obf.

occlusal bite force (obf) is an indicator of the functional status of the masticatory system. the level of maximum occlusal bite force (mobf) results from the combined action of the jaw elevator muscles modified by jaw biomechanics and reflex mechanisms. the measurement of obf has been widely used in dentistry to provide useful data for the evaluation of jaw muscle function and activity as well as effectiveness of prosthetic therapy. many indicators have been believed to assess the functional status of the masticatory system, such as body size, bite force, number of functional tooth units, and the occlusal contact area. dental status formed with dental fillings, dentures, position and the number of teeth is an important factor in the value of the obf. many studies were conducted to evaluate the effect of dental caries on obf. tsai et al. found a negative correlation between mobf and the number of decayed teeth. su et al. reported that the overall tooth decay was not related to the strength of obf. they suggested that the severity of tooth decay may be more important than the number of teeth exhibiting decay. stainless steel crowns (sscs) are considered the treatment of choice for severely decayed but restorable primary molars. a recent systematic review by seale and randall confirmed their previous work and reviews and appeared to continue to be supportive and in favor of sscs. sscs has been blamed for premature contact related discomfort in the first few weeks after placement of sscs. zee and amerongen reported that premature contacting ssc restored teeth will equilibrate over time and return to pretreatment levels in 15 to 30 days. several opinions have been reported by parents, children and dentists regarding the improved mastication efficiency after placement of the sscs. however, the effects of sscs placement on primary molars on obf have not yet been investigated

Eligibility criteria:
inclusion criteria:- caucasian * healthy child * in the primary dentition stage * class i occlusion * no facial asymmetry * no cross bite * have caries in the eight primary molars indicating placement of sscs, with no reported pain on biting and no previous restorations * no gingival inflammation * no para functional habits exclusion criteria: did not meet the inclusion criteria stated above -
erythrocyte glutamine level relation to pulmonary hypertension risk in beta thalassemia major children

Conditions: Thalassemia in Children; Pulmonary Hypertension; Hemolysis

Summary: the study will investigate the relation between erythrocyte glutamine/glutamate ratio and pulmonary hypertension risk in egyptian thalassemic children in assiut university children hospital


Eligibility criteria:
inclusion criteria: * established diagnosis of thalassemia. * ph risk documented by doppler echocardiography, defined as tricuspid regurge velocity (trv) equal to or greater than 2.5 m/s exclusion criteria: * acute crisis or hospitalization within 1 month of enrollment * hepatic dysfunction (sgpt greater than 3x normal) * renal dysfunction (creatinine greater than 2x normal) * patients on sildenafil (viagra), calcium channel blockers or other drugs for the control of ph.

Keywords: thalassemia glutamine/glutamate ratio pulmonary hypertension
evaluation of safety and efficacy of artemether-lumefantrine tablets in african infants and children with uncomplicated p. falciparum malaria

Conditions: Plasmodium Falciparum Malaria

Summary: this study will assess the safety and efficacy of artemether-lumefantrine tablets (6-dose regimen) in african infants / children with acute uncomplicated falciparum malaria.


Eligibility criteria:
inclusion criteria: * male or female weighing ≥ 5kg and ≤ 25kg * p. falciparum parasitemia between 1,000 and 100,000 parasites/mm3 * with confirmed diagnosis of uncomplicated malaria caused p. falciparum parasite exclusion criteria: * complicated malaria * ingestion of various antimalarial drugs, or other drugs influencing cardiac function in the previous 4 weeks before study entry to 8 weeks * severe anaemia * severe malnutrition * malaria due to other than p. falciparum other protocol-defined inclusion/exclusion criteria may apply

Keywords: malaria co-artemether auditory plasmodium falciparum marsh fever remittent fever artemether artemisinins lumefantrine child infant africa
epstein-barr virus antibody and epstein-barr virus dna for nasopharyngeal carcinoma screening

Conditions: Nasopharyngeal Carcinoma

Summary: the investigators intend to compare epstein-barr virus antibody and epstein-barr virus dna screening efficacy in first-degree relatives of nasopharyngeal carcinoma patients.

the investigators intend to test epstein-barr virus antibodies (viral capsid antigen-immunoglobulin a， epstein-barr nuclear antigen 1-immunoglobulin a， early antigen-immunoglobulin a， zta-immunoglobulin a， rta-immunoglobulin g, bnlf 2b) by elisa and epstein-barr virus dna by quantitative polymerase chain reaction, target sequencing and crispr-associated protein 12a in nasopharyngeal brushing and plasma of the same population at high-risk of nasopharyngeal carcinoma so as to determine the best method in nasopharyngeal carcinoma screening.

Eligibility criteria:
inclusion criteria: * residents in southern china * 30-62 years old * male * a first-degree relative of at least one nasopharyngeal carcinoma patient * no medical record of nasopharyngeal carcinoma * eastern cooperative oncology group score of 0-2 * be able to comprehend, sign, and date the written informed consent document to participate in the study exclusion criteria: * history of nasopharyngeal carcinoma * heavy cardiovascular, liver or kidney disease * on systemic steroid or immunosuppressant treatment or active autoimmune disease

Keywords: nasopharyngeal carcinoma screen ebv dna ebv antibody
protein eating patterns and weight loss

Conditions: Obesity

Summary: the purpose of this study is to determine the effects of daily protein intake patterns on body composition and eating behaviors during weight loss.

the reinforcing value of food varies greatly among individuals, but is strongest for those who are overweight or obese. reducing energy intake, which is necessary for overweight and obese individuals to achieve a healthier body weight, increases the reinforcing value of food - especially for energy-dense snack foods. food is a powerful reinforcer and is associated with energy intake; making it a primary contributing factor to an individual's weight loss struggle. developing a way to decrease or limit the increase in food reinforcement during energy deficits would have important clinical impact. high-protein diets are known to be efficacious for weight loss and recently have been shown to decrease stimulation of the reward areas of the brain that stimulate reward-driven eating behavior. nonetheless, sustaining a high-protein diet can be difficult, especially for women. consuming a modest amount of protein at each meal may be better tolerated. however, we do not know whether this pattern of protein intake can assist women in staying "on track" with weight loss goals. this study will help begin to elucidate the connections between the daily pattern of protein intake on diet adherence, alterations in food reinforcement, and favorable body composition changes during weight loss.

Eligibility criteria:
inclusion criteria: * bmi 28-45 kg/m2 exclusion criteria: * unable or unwilling to consume animal products * unable or unwilling to attend treatment group meetings * had more than a 10% change in body weight in the 2 months prior to study start date * consuming a specialized diet * have a history of and eating or gastrointestinal disorder * currently or planning on becoming pregnant during the study timeline * lactating * have an uncontrolled metabolic illness/disease (fasting glucose \>125 mg/dl) * have uncontrolled hypertension (\>160/99 mm hg) * have cancer or in short-term remission (less than 3 years) * have an infectious disease * suffer from alcohol or drug abuse * use tobacco and/or e-cigarette products on a regular basis * taking medications known to affect energy expenditure and appetite

Keywords: protein weight loss
constraint-induced movement therapy after stroke

Conditions: Stroke; Hemiplegia Following Ischemic Stroke

Summary: constraint-induced movement therapy (cimt) is a neurological rehabilitation treatment designed to improve upper and lower extremities motor functions after stroke. the basis of cimt is improving the function of the affected limb after a stroke by restricting the use of the healthy limb and forcing the use of the affected side. the core strategy of cimt is the application of movement techniques, behavioral techniques and restriction methods to increase the frequency of use of the affected limb in stroke patients, improve the quality of movement of the affected limb in real-life scenarios, prevent or correct the learned non-use of the affected limb, and promote the recovery of motor function in the affected limb. this method induces the use of the affected limb, corrects or reverses habitual disuse and neglect of the affected limb, and provides structural and functional training and repeated practice opportunities for the affected limb.


Eligibility criteria:
inclusion criteria: * grade 1 or 1+ modified ashower scale * walk independently exclusion criteria: * moderate to sever spasticity * balance dysfunction

Keywords: constraint-induced movement stroke motor function body balance