Kornimate/medical-research-clean huggingface dataset:
efficacy of glaucoma drop aids in medication compliance in the patient population at boston medical center

Conditions: Glaucoma

Summary: the purpose of this study is to determine whether glaucoma drop aids will be cost-effective in delivery of ophthalmic medications by improving medication compliance, visual function, and even decreasing medication waste in the patient population at boston medical center (bmc).

patients being treated for their glaucoma at bmc's yawkey eye clinic will be selected according to the inclusion and exclusion criteria. the three drop aids used in this study will be the fabrication autodrop eye drop guide, owen mumford op 6100 autosqueeze, and the simply touch eye drop applicator. patients will be randomly placed on one of these drops aids for a total of 3 study groups or the no drop aid control, for a total of 4 groups. prior to use of the drop aid, patients will be instructed on how to use the drop aid by a resident physician and a pre- intervention intraocular pressure check will be performed by the resident physician using an applicator. intraocular pressure is the only adjustable risk factor for glaucoma; thus, glaucoma treatments slow progression of glaucoma by reducing intraocular pressure. in addition, patients will be requested to deliver their drops with the drop aid with every use. furthermore, each patient will record the number of days taken to complete the glaucoma medication bottle while using the drop aid. at the 3 and 6 week marks, the patient will fill out a satisfaction survey. patients will need to return to the clinic at the 6 week mark and can fill out the satisfaction survey at the clinic in addition to checking the intraocular pressure post-intervention. thus, the number of subject contact will be two, pre and post-intervention, the duration of participation for each subject will be 6 weeks, and the patient will also be required to fill out two satisfaction surveys. the effectiveness of the drop aids will be compared to the two controls and measured with any changes in intraocular pressure readings, length of time to medication completion, and patient satisfaction according to the surveys.

Eligibility criteria:
inclusion criteria: * age 18 years or greater * currently on the same topical medication for treatment of glaucoma for a minimum of two months * patient of boston university eye associates * agrees to use the drop aid with each delivery, return to the clinic after 6 weeks of using the drop aid, document completion of medication drops and fill out survey at the end of the 6 weeks exclusion criteria: * less than age 18 years * changes glaucoma medication within the past two month or recent glaucoma surgery * older than 89 years of age * not a patient of the boston university eye associate

Keywords: glaucoma drop aid
nodal status in adenocarcinoma of the esophagus an cardia

Conditions: Adenocarcinoma of the Esophagus; Adenocarcinoma of the Gastric Cardia

Summary: adenocarcinoma of the distal esophagus and cardia are grouped among the thoracic tumors according to the tnm 7th ed., however controversy is pending on the unique or dual pathogenesis (gerd or gastric-like cancerogenesis). it has been shown that biological patterns differ according to the presence (+) or absence (-) of barrett's epithelium (bim) and gastric intestinal metaplasia (gim) in the fundus and antrum. lymphatic metastatic spreading may differ according to the type of tumor. the investigators retrospectively investigated the pathways of lymphatic spreading in 194 consecutive patients who received radical surgery for adenocarcinoma of the esophagus and cardia with or without bim and gim.

the assumption that adenocarcinoma of the esophagus and cardia (adec) originates only from the sequence intestinal metaplasia followed by dysplasia and cancer is controversial. it has been shown that biological patterns differ according to the presence (+) absence (-) of barrett's epithelium (bim) and of gastric intestinal metaplasia (gim) in the fundus and antrum. lymphatic metastatic spreading may differ according to the type of tumor. preoperatively patients underwent histological search for barrett's esophagus (bim) in mucosa surrounding (adec) and intestinal metaplasia in the gastric corpus and antrum mucosa (gim). patients in which bim was documented underwent sub total esophagectomy and gastric pull up (group 1), others underwent esophagectomy at the azygos vein + total gastrectomy with roux y esophagojejunostomy (group 2). radical lymphadenectomy was identical in both procedures except for the greater curvature station.

Eligibility criteria:
inclusion criteria: * preoperative diagnosis of adenocarcinoma of the distal esophagus and cardia * preoperative from local to locally advanced disease * absence of neoadjuvant therapy exclusion criteria: * neoadjuvant therapy * metastatic disease * unfit for surgery
idiopathic pulmonary fibrosis: a case-control study

Conditions: Lung Diseases; Pulmonary Fibrosis; Lung Diseases, Interstitial

Summary: to determine risk factors for idiopathic pulmonary fibrosis.

background: idiopathic pulmonary fibrosis is a progressive and generally fatal disease that causes fibrosis of the pulmonary interstitium. while many environmental agents cause diseases clinically similar, the etiology of idiopathic pulmonary fibrosis suggests that environmental agents could incite the tissue injury that results in the disease; furthermore, host characteristics could have an important role in determining the magnitude of the host response to the agent initiating injury. design narrative: in this case control study, cases were ascertained at the multiple collaborating centers and controls were identified by telephone screening. a telephone interview was conducted to collect information needed to test hypotheses concerning cigarette smoking, occupational exposure, indoor exposures, other environmental factors, and host factors. to limit disease misclassification, two pathologists experienced with interstitial diseases of the lung reviewed histopathological material from all cases to exclude entities other than interstitial lung fibrosis and to fully characterize the cases clinically. the mortality of this large series of cases was also described.

Eligibility criteria:
no eligibility criteria
impact of balanced slat colloid hes 130/0.42 on coagulation profiles in patients undergoing spinal cord tumor surgery

Conditions: Coagulation

Summary: the purpose of study is to compare the effect of coagulation profile in patients receiving intraoperative balanced salt colloid undergoing spinal cord tumor surgery.


Eligibility criteria:
inclusion criteria: * adult patients over the age of 20 scheduled for spinal tumor removal and fixation exclusion criteria: * 1. renal failure 2. preexisting congestive heart failure(nyha iii \~ iv) 3. anemia 4. coagulopathy 5. abnormal liver function 6. anti coagulation/anti platelet ,edication 7. foreigner, illiterate 8. disabled person,

Keywords: balanced salt colloid, coagulation profiles, spinal cord tumor
prevention of lymphorrhea by lanreotide in axillary dissection for breast cancer

Conditions: Lymphocele

Summary: injection the day before surgery of 90 mg of lanreotide lp sub-cutaneously or placebo. evaluation of the lymphorrhea in the 2 arms of the study

patients will be recruited among patient refered to our department for a breast cancer and needing an axillary dissection. enrolled patients will have an injection of lanreotide or placebo the day before surgery when they arrive in their room. the quantity of lymph in axillary drain will by daily noted until day 4. the patient will be evaluated at d15, d30 and m6 for pain, lymphocele and adverse events. data will be compared in the 2 groups.

Eligibility criteria:
inclusion criteria: * adult patient (\> 18 years), * patient undergoing an axillary lymphadenectomy for breast cancer * patient giving her agreement after being informed exclusion criteria: * patients that don't understand the trial * type 2 diabetic patients * cyclosporine treatment * biliary lithiasis * pregnancy or breast feeding * allergic reaction to lanréotide or same class treatments * patient included in another trial within the last 30 days

Keywords: axillary lymphocele breast cancer
everolimus-eluting stent for bifurcation coronary lesions: comparison of simple versus complex techniques

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to evaluate the efficacy and safety of the treatment of true bifurcation lesions with the xience v stent using the simple strategy (stent in main vessel and provisional t-stenting in the side branch) compared to the complex strategy (stent in main vessel and t-stenting in the side branch).


Eligibility criteria:
inclusion criteria: * patients over 18 years old. * true bifurcation lesion (medina classification 1-1-1), in at least one main coronary vessel. diameter of main vessel between 2,5-4mm, and diameter of side branch 2mm or greater. exclusion criteria: * significant left main stenosis. * st elevation myocardial infarction \< 48 h. * thrombus burden target lesion. * ejection fraction \< 30%. * severe renal insufficiency (creatinine \> 3 mg/dl).

Keywords: stents angioplasty coronary artery disease bifurcation coronary lesions
evaluation of a novel electronic transanal irrigation system - navina™ smart

Conditions: Neurogenic Bowel

Summary: this study is designed as an open, prospective, single arm, multicenter study in order to investigate patient satisfaction, perception and compliance for the novel navina smart, a transanal irrigation (tai) system. approximately 30 male and female subjects who are currently practicing tai, will be followed during a 4-week period of use of navina smart. observational data on satisfaction, perception, compliance, bowel regimen, tai therapy and tai frequency will be collected via patient reported outcome (pro) questionnaires.


Eligibility criteria:
inclusion criteria: 1. provision of informed consent 2. males and females, aged 18 years and over 3. practice tai since at least 2 months and at least two times per week 4. able to read and fill out a paper pro questionnaire as judged by the principal investigator or a sub-investigator exclusion criteria: 1. any confirmed or suspected diagnosis of anal or rectal stenosis, active inflammatory bowel disease, acute diverticulitis, severe diverticulosis, colorectal cancer, ischemic colitis, history of life-threatening autonomic dysreflexia, bleeding disorders, unspecified peri-anal conditions 2. untreated rectal impaction 3. any radiotherapy to the pelvis 4. any current treatment with anticoagulants (not including aspirin or clopidogrel) 5. any current treatment with long-term systemic steroid medication (not including inhalation agents and/ or local topical treatment) 6. any prior rectal or colonic surgery (not including anal procedures \>3 months ago, e.g. haemorrhoid excision) 7. anal, rectal and/or colonic endoscopic polypectomy within the previous 4 weeks 8. overt or planned pregnancy 9. ongoing symptomatic urinary tract infection as judged by the principal investigator or a sub-investigator 10. diagnosed psychiatric illness, considered as unstable by the principal investigator or a sub-investigator 11. involvement in the planning and conduct of the study (applies to both wellspect healthcare staff and staff at the study site) 12. previous enrolment in the present study 13. participation in another clinical study within the last 30 days that may interfere with the present study
peep influence on gas exchange during early weaning

Conditions: Respiratory Failure

Summary: the purpose of this study is to determine the differences in oxygenation and decarboxylation between two weaning processes.

first, during controlled mechanical ventilation all patients will be ventilated for 5 minutes with 100% oxygen. after 5 minutes an pao2/fio2 will be calculated and compared with a pao2/fio2 during ventilation with fio2 - 30%. the patients will be divided in two sections: section a are the patients with less than 24 hours mechanical ventilation until weaning start. section b are the patients with more than 24 hours until weaning start. the patients in every section will be further divided in two groups. group 1 will be weaned starting with a peep equal with p mean during bipap, group 2 will be weaned starting with a peep equal with peep during bipap. further, the weaning will be conducted after an known algorithm. the differences in the oxygenation and decarboxylation will be measured after 30 and 120 minutes for group a and after 30, 120, 240, 360 minutes for group b.

Eligibility criteria:
inclusion criteria: * all patients that are mechanical ventilated on the intensive care unit. exclusion criteria: * patients under 18 years of age * patients that where in an other study in the last 30 days * patients that are enrolled in other studies * pregnant woman * nursing mothers * existing severe lung disease * existing copd gold iv
lung volume reduction coil treatment in emphysema.

Conditions: Emphysema

Summary: * background: medical therapeutic options for the treatment of emphysema remain limited. lung volume reduction surgery is infrequently used because of its high morbi-mortality. endobronchial lung volume reduction coil (lvrc(®), pneumrx, mountain view, ca) treatment has been recently developed and has been shown to be feasible and associated with an acceptable safety profile, while resulting in improvements in dyspnea, exercise capacity and lung function. the objective of this study is to analyze the cost effectiveness of lvrc treatment in severe emphysema. * methods:this prospective, multicenter study, randomized with a 1:1 ratio (lvrc vs conventional treatment) will include 100 patients who will be followed up for 1year. the primary outcome measure is the 6-month improvement of the 6-minute walk test: the percentage of patients showing an improvement of at least 54m will be compared between groups. a cost-effectiveness study will estimate the cost of lvrc treatment, the global cost of this therapeutic option and will compare the cost between patients treated by lvrc and by medical treatment alone. * expected results:this study should allow validating the clinical efficacy of lvrc in severe emphysema. the cost-effectiveness study will assess the medical-economic impact of the lvrc therapeutic option.


Eligibility criteria:
inclusion criteria: * bilateral emphysema on chest ct scanner * post bronchodilator fev1 \< 50 % * total lung capacity \> 100 % * residual volume \> 220 % * dyspnea score between 2 and 4 based on the mmrc scale * stopped cigarette smoking for more than 8 weeks * pulmonary rehabilitation within the previous twelve months * consent form signed * covered by medical insurance exclusion criteria: * post bronchodilator fev1 \< 15% * post-bronchodilator change in fev1 \> 20% * severe recurrent respiratory infections requiring more than 2 hospitalization stays within the past twelve months * copd exacerbation requiring hospital stay within 3 months * pulmonary hypertension (pulmonary systolic pressure \>50 mmhg on cardiac echo) * patient unable to perform a 6-min walking test in room air * giant bulla of more than 1/3 of the lung field on chest ct * strictly homogeneous emphysema on chest ct * clinically significant bronchiectasis * past history of lobectomy, lung volume reduction surgery, lung transplantation * any extrapulmonary diseases compromising survival or evaluation within the protocol (severe cardiac disease, severe renal insufficiency, cancer...) * lung carcinoma or pulmonary nodule on ct scan requiring chest ct scan follow-up * contra-indication to general anesthesia * oral anticoagulant treatment (antivitamin k) * allergy to nitinol * inclusion in an other study assessing respiratory treatments * patient protected by the law

Keywords: chronic obstructive pulmonary disease endoscopic lung volume reduction
telemedicine for unhealthy alcohol use in persons living with hiv using ceta

Conditions: Hiv; Alcohol Problem

Summary: this study is designed to examine the efficacy of a brief intervention plus a cognitive-behavioral intervention compared to brief intervention alone to address unhealthy alcohol use and comorbid mental health symptoms to improve hiv outcomes among people living with hiv in alabama.

participants will be randomly assigned to receive either alcohol brief intervention (bi) or bi plus common elements treatment approach (t-ceta) via telephone. participants will receive either 1 phone session of bi or 6 to 12 weekly phone sessions of bi + t-ceta. follow ups will occur at 6 and 12 months with participants. participants will provide data on alcohol use, mental health comorbidities, hiv outcomes, medication adherence, and laboratory collections (cd4+ t cell count, viral load, and an alcohol biomarker: peth) at the baseline assessment and again at the 6 and 12 month follow ups. the study will also conduct mixed methods implementation measures with a subset of participants who are selected across various strata (i.e. gender, age, trial arm).

Eligibility criteria:
inclusion criteria: * 18 years of age or older * living with hiv infection * receiving hiv care at 1 of 4 participating aqmg sites (alabama quality management group sites - i.e. ryan white hiv/aids program-funded community clinics in alabama) * unhealthy alcohol use documented on the audit survey delivered via pro (i.e. 4 or greater points for women and greater than 8 points for men). exclusion criteria: * inability to use a mobile phone due to cognitive or physical impairments * unable to speak sufficient english to provide informed consent and receive cognitive behavioral therapy * active suicidality or psychosis * risk for acute alcohol withdrawal or seizures

Keywords: hiv outcomes unhealthy alcohol use mental health medication adherence
inspiratory muscle training with normocapnic hyperpnea in chronic obstructive pulmonary disease (copd)

Conditions: COPD

Summary: many studies suggest that inspiratory muscles training by means of normocapnic hyperpnea improves exercise tolerance in healthy subjects. no information is available about the use of this training in copd patients even if other methods (such as threshold loading and resistive loading) have been shown to be effective in terms of inspiratory muscle function, health-related quality of life and exercise tolerance. this study is designed to evaluate the effects of normocapnic hyperventilation by means of spirotiger®, an instrument training the respiratory muscles, avoiding hypocapnia (using the methodology of isocapnic hyperpnoea)in copd patients.


Eligibility criteria:
inclusion criteria: * copd patients. all patients are at stable state, free from an exacerbation from at least 3 months. exclusion criteria: * copd patients with a recent history of cardiovascular disease, neurologic disease and other diseases that would interfere with the training.

Keywords: copd inspiratory muscles training
effect of high protein diet on adiponectin and inflammation among overweight and obese children

Conditions: Body Mass Index Quantitative Trait Locus 5 Disorder; Tangier Disease

Summary: the investigators aimed to determine the effects of hp diet on adiponectin and inflammatory factors among overweight and obese children.


Eligibility criteria:
inclusion criteria: * bmi \> 85th * age of 6-11 years * no history of chronic diseases * taken medications exclusion criteria: * do not prescribe their diet * mental retardation
diagnostic feasibility of 100 hz tetanic stimulation

Conditions: Polyneuropathies

Summary: the goal of this observational study is to investigate the applicability of 100 hz tetanic stimulation with an electromyography device in the exclusion of postoperative residual neuromuscular block. the aim is to determine whether fatigue develops with 100 hz tetanic stimulation in anaesthetized, non-relaxed patients with normal or abnormal baseline electroneurographic (eng) findings.

the aim of the present study is to investigate the applicability of 100 hz tetanic stimulation with an electromyography (emg) device. the aim is to determine whether fatigue develops with 100 hz tetanic stimulation in anaesthetized, non-relaxed patients with normal or abnormal baseline electroneurographic (eng) findings. electric responses of the musculus digiti minimi elicited by supramaximal stimulation of the ulnar nerve at the carpal tunnel are monitored. alpine biomed eng-emg device with keypoint software version 5.11 is used for the examinations. the exposed arm is fixed on the armboard, the skin is degreased and then the electrodes for monitoring are mounted lege artis. after the anesthesia has been induced, eng of the ulnar nerve is examined. based on the results of the eng test, patients are divided into separate groups (normal or abnormal eng). during the eng test, the supramaximal current is determined. afterwards, repetitive tetanic stimulation of the defined frequency (60 and 100 hz) and duration (5 sec) is applied to the two test groups at the current according to the test plan. the clinical utilities of the study results are: * determination of the "safety margin" of neuromuscular junction, which is not provided by routine monitoring. * to investigate how comorbid status (especially chronic conditions affecting peripheral nerves such as polyneuropathy) influences the feasibility of tetanic stimulation in the diagnostics of residual neuromuscular block and safety margin.

Eligibility criteria:
inclusion criteria: * asa 1-3; * bmi 18.5-25 (normal body weight); * patient is in supine position with one arm accessible. exclusion criteria: * diseases with impaired neuromuscular function (myopathies, severe liver and kidney failure); * drugs affecting neuromuscular function (magnesium, aminoglycosides); * pregnancy (pregnancy tests are carried out in women of childbearing age to rule out pregnancy); * breast-feeding; * acute surgery

Keywords: electromyography electroneurography tetanic stimulation residual neuromuscular block neuromuscular monitoring