Kornimate/medical-research-clean huggingface dataset:
comparison of postoperative aqueous flare after 20g versus 23g pars plana vitrectomy

Conditions: Macular Hole; Macular Pucker

Summary: to compare postoperative inflammation and breakdown of blood-retinal barrier as measured by a laser flare-cell meter in 20g versus 23g vitrectomy.


Eligibility criteria:
inclusion criteria: age \> 18 years macular hole macular pucker willing to perform follow up written signed consent exclusion criteria: other relevant eye disease: retinal detachment, provect cataract, diabetic retinopathy, amd, relevant glaucoma, pre-surgery except for cataract surgery
preoperative methylprednisolone in endovascular aortic repair

Conditions: Abdominal Aortic Aneurysms

Summary: the purpose of this study is to attenuate the systemic inflammatory response after endovascular repair of abdominal aortic aneurysms, by administration of a single preoperative dosage of methylprednisolone.


Eligibility criteria:
inclusion criteria: * elective endovascular repair of an asymptomatic abdominal aortic aneurysm. * informed signed consent exclusion criteria: * positive hiv status, positive hepatitis b or c status * immunoinflammatory disease - except topically treated skin disease and respiratory disease. * glaucoma * gastric or duodenal ulcer * systemic fungal infection * immunosuppressive treatment * current treatment for cancer * allergy towards contents of solu-medrol * alcohol consumption: men \> 21 drinks and women \> 14 drinks weekly * pregnancy * lack of informed signed consent * patients where follow up is planned at other location than rigshospitalet.

Keywords: endovascular aortic repair methylprednisolone systemic inflammatory response syndrome
safety and immunogenicity of 20vpnc in toddlers with 2 prior doses of prevenar 13

Conditions: Pneumococcal Disease

Summary: the purpose of this study is to understand the safety and effects of a study vaccine (20vpnc) in toddlers who had 2 prior doses of prevnar 13. this study is being conducted in children who: * are between 12 to 23 months of age; * are healthy as determined by the study doctors; * have received 2 doses of prevnar 13 during the first year in life. participants in this study will receive either 1 dose or 2 doses of the study vaccine or 1 dose of prevnar 13 as a shot in the muscle. during the study, participants will have to come to the study clinic to receive the vaccines and have blood sample collected. the study team will work with participants' parents or legal guardians to monitor any unwanted reactions to the vaccines. participants are expected to take part in this study for about 1 or 3 months, for 1 dose or 2 dose schedules, respectively.


Eligibility criteria:
inclusion criteria: * male or female toddlers ≥12 to \<24 months of age at the time of consent * healthy toddlers determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study * 2 infant doses of prevenar 13 prior to 12 months of age exclusion criteria: * history of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) * major known congenital malformation or serious chronic disorder * other chronic medical or laboratory abnormality that may increase the risk associated with study participation or, in the investigator's judgment, make the participant inappropriate for the study. * previous vaccination with any investigational pneumococcal vaccine, or planned receipt through study participation
safety and clinical and microbiological efficacy of the combination of fluconazole and secnidazole for the treatment of symptomatic vaginal discharge

Conditions: Vaginal Discharge

Summary: genital tract infections (gtis) have increased in the past decade and there is an association between sexually transmitted infections (stis) and other infections like bacterial vaginosis (bv), with the hiv transmission. bv and candida are the most common causes of vaginal infections in symptomatic women, the prevalence of bv being 22-50% and the prevalence of candida 17-39%. in an effort to reduce the transmission of gtis, the world health organization (who) proposed a syndromic diagnostic approach as a low cost alternative in places with no access to laboratory diagnostic tests. justification. in patients with syndrome of vaginal discharge, an effective treatment against candida albicans, trichomonas vaginalis, and bacterial vaginosis is adviced, therefore, for syndromic management of symptomatic vaginal discharge the combination of fluconazole and secnidazole could be used. no studies evaluating this combination were found in the literature reviewed. objectives: to describe the safety and the clinical and microbiological efficacy of a single oral dose of a combined treatment with secnidazole + fluconazole for the syndromic management of symptomatic vaginal discharge. methods: design: open label, uncontrolled clinical trial to estimate clinical efficacy and safety of the combination of fluconazole and secnidazole for the treatment of symptomatic vaginal discharge. the participants will be sexually active women with lower genital tract symptoms (leukorrhea, itching, burning, pain, foul-smelling vaginal discharge, or urethral symptoms) compatible with symptomatic vaginal discharge syndrome. the study will be conducted in an outpatient service of a hospital in bogota, colombia. given the descriptive character of the study, no a priori hypothesis is considered. a consecutive convenience sample size of 100 symptomatic patients is calculated. the statistical analysis will be performed with stata 11.0 software (college station, texas, usa). simple and relative frequencies and measures of central tendency and dispersion appropriate for the distribution of the variables will be calculated. the study has been submitted and approved by the ethics committee of the faculty of medicine of the national university of colombia and the institutional review board of the participating institution. all women must sign a written informed consent form agreeing to voluntarily participate in the study.


Eligibility criteria:
inclusion criteria: * sexually active women with lower genital tract symptoms compatible with bv or vaginitis exclusion criteria: * patients with a clinical diagnosis of cervicitis * severe medical conditions * liver disease * allergies, or known reactions to the drugs under study were excluded from the study * pregnant women * women who were not yet sexually active * women who had previously participated in the study * women who had received antibiotic therapy in the previous 14 days

Keywords: vaginosis, bacterial; candidiasis, vulvovaginal
transverse supraumbilical versus pfannenstiel incision for cesarean section in morbidly obese women

Conditions: Cesarean Section

Summary: this study aims to evaluate the efficacy and safety of transverse supraumbilical incision over pfannenstiel incision in performing cesarean section for morbid obese pregnant women.

research question in morbidly obese women undergoing cesarean section, is transverse supraumbilical incision superior to pfannenstiel incision? research hypothesis transverse supraumbilical incision is superior to pfannenstiel incision in morbidly obese women undergoing cesarean section.

Eligibility criteria:
inclusion criteria: * bmi more than 40 kg/m2 * women scheduled for cs exclusion criteria: * patients receiving steroids or anticoagulation
the clinical outcomes following transfer of blastocysts cultured from thawed cleavage stage embryos

Conditions: Infertility

Summary: recent improvements in cell culture systems have led to a shift in in vitro fertilization (ivf) practice from early cleavage stage embryo transfer (et) to blastocyst transfer. blastocyst culture and transfer could theoretically provide better synchronization between the embryo and the uterine endometrium. the purpose of this study is comparing pregnancy rates and implantation rate following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage embryos.

the proposal of this study approved by our institutional review boards and institution's ethical committee, and all participants will sign a written consent before enter to study. all patients will be randomly divided into two groups of thawed cleavage embryo transfers and transfers of blastocysts from thawed cleavage embryos. embryos will be transferred in hormone replacement cycles. preparation of the endometrium will be started in the second day of menstruation and will be continued according to their transfer type (blastocyst or cleavage). βhcg will be assessed 14 days after embryo transfer. treatment cycle outcomes will be compared between 2 groups.

Eligibility criteria:
inclusion criteria: * the patients with first type of infertility * age ≤ 37 years * long ovulation induction protocol exclusion criteria: * any previous surgery on the uterus and ovaries * uterine factor infertility * sever male factor infertility (tese, tesa ،oligoteratozoospermia) * recurrent abortion * the women with poor ovarian reserve

Keywords: cleavage stage blastocyst transfer cryopreservation
stunning after balloon occlusion

Conditions: Coronary Artery Disease

Summary: the aim of this study is to examine in-depth cardiac function and morphology after short-term coronary occlusion by balloon inflation in patients with stable coronary artery disease (cad) who undergo percutaneous coronary intervention (pci).

primary objectives: 1. to determine the time-course for the resolution of regional myocardial function after short-term coronary artery occlusion in patients with stable cad who undergo pci. secondary objectives: 2. to confirm by cardiac magnetic resonance imaging that no myocardial injury occurs after short-term coronary occlusion in patients who undergo pci due to stable cad. 3. to establish a clinical model for studying myocardial stunning.

Eligibility criteria:
inclusion criteria: 1. age \>18 years. 2. stable cad with indication for pci of a lesion in either of the following coronary segments: 1. 6 or 7 (proximal or mid left anterior descending coronary artery) 2. 11 (proximal left circumflex coronary artery) 3. 1 or 2 (proximal right coronary artery) 3. normal cardiac function in the myocardial segments subtended by the target vessel, as assessed by echocardiography at the time of coronary angiography. 4. written informed consent obtained. exclusion criteria: 1. pre-existing heart failure 2. known pre-existing irreversible regional or global wall motion abnormalities affecting the myocardial segments subtended by the target vessel. 3. severe valvulopathy 4. thrombolysis in myocardial infarction (timi) flow \<3 in the target vessel.

Keywords: percutaneous coronary intervention myocardial stunning
a pilot study involving an asthma management program for inner-city early head start children

Conditions: Asthma

Summary: the early head start program serves lower socioeconomic inner-city children from birth to 3 years. this population has a higher incidence of asthma due to increased exposures. the primary objective of this study is: to evaluate the effect of early identification of these high risk, inner-city asthmatic infants, age 1-3 years, and early treatment with pulmicort respules on asthma morbidity (asthma symptoms and use of rescue medications), infant pulmonary functions, and use of health care resources (unscheduled clinic visits, emergency room visits and hospitalizations). to obtain pilot behavior information using carey temperament scale, bitsea and expand to itsea if indicated.


Eligibility criteria:
inclusion criteria: * children 12-36 months of age with a history of wheezing or airway reactivity responding to bronchodilators, or diagnosed with asthma by a physician. exclusion criteria: * children less than 12 months or greater than 36 months of age. * children diagnosed with attention deficit disorder by a physician or psychologist.

Keywords: asthma children
an open label trial for treating carpometacarpal osteoarthritis of the thumb: pilot study

Conditions: Carpometacarpal Osteoarthritis

Summary: the purpose of this study is to find out if hyaluronan, an injectable medication for knee arthritis, also works for arthritis at the base of the thumb. this study will also evaluate how good ultrasound is at visualizing medication in the thumb joint. we are no longer recruiting for this part of the open label trial.


Eligibility criteria:
inclusion criteria: * radiographic evidence of at least moderate narrowing (joint space \< 1mm) or the presence of osteophytes or sclerosis at the carpometacarpal joint * patient complaint of unacceptable pain despite modification of activity, a trial of splinting and a therapeutic dose of nsaids * if bilateral disease, only the most severely involved hand, (as defined by vas for pain), will be entered in the study. * proficiency in english. exclusion criteria: * previous bad injury to the thumb * previous hand surgery on the study thumb * known hand comorbidities (i.e. carpal tunnel syndrome, de quervains tenosynovitis etc) * rheumatoid arthritis or lupus * bleeding problems * being on blood thinners (except aspirin) * known allergies to any of the medications being used * allergies to chicken products * current use of oral steroids * cancer that is not cured or in remission * severe diabetes * a serious infection somewhere else in the subject's body

Keywords: osteoarthritis hyaluronan carpometacarpal outcomes
assessment of mandibular osseous changes in patients with end stage renal failure

Conditions: Diagnosis

Summary: this study will be observational study. the goal of this study is to evaluate the quality of mandible and to assess the correlation between the jaw bone quality in a sample of egyptian patients with chronic renal failure and duration of dialysis using cbct.

this study will be observational study. the goal of this study is to evaluate the quality of mandible and to assess the correlation between the jaw bone quality in a sample of egyptian patients with chronic renal failure and duration of dialysis using cbct. twenty-six subjects will be included in this study. these will comprise (13) ckd patients "the study group" and (13) healthy patients "the control group" recommended for cbct imaging for implant placement. the control group will be selected from the prosthodontic department and oral medicine department of faculty of oral and dental medicine, cairo university, the study group will be selected from nephrology and the artificial kidney unit el kasr -al ain hospital, cairo university.

Eligibility criteria:
inclusion criteria: * end stage renal failure (in study group) * undergone hemo-dialysis, three times/week (in study group) * duration of dialysis (≥1 year) (in study group) * pth (140-630) * age group (18-40 years) * mandible * free from any other systemic disease affecting the bone quality * egyptian population exclusion criteria: * early stage of renal disease * patients with diabetes, hyperthyroidism, postmenopausal osteoporosis * maxilla * other language * completely edentulous patients.

Keywords: cbct bone quality renal failure
response to massage in neck pain

Conditions: Neck Pain

Summary: this study is interested in whether baseline measures of pain sensitivity i.e. the amount of pressure required to feel pain predicts pain relief following a pain inducing massage and whether pain relief following a pain inducing massage is different than a pain free massage or placing your hand in a cold water bath. participants with neck pain will be randomly assigned to receive a pain inducing massage, pain free massage, or to place their hand in a cold water bath.


Eligibility criteria:
inclusion criteria: * age 18 to 60 years old * currently experiencing neck pain with or without arm pain * neck pain symptom intensity rated as 4/10 or higher during the last 24 hours * neck pain for greater than or equal to 3 months exclusion criteria: * non- english speaking * systemic medical conditions known to affect sensation (e.g. diabetes) * history of neck surgery or fracture within the past 6 months * current history of chronic pain condition other than neck pain * diagnosis of cervical radiculopathy or cervical myelopathy * history of whiplash * currently using blood thinning medication * any blood clotting disorder such as hemophilia * any contraindication to application of ice, such as: uncontrolled hypertension, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, and circulatory compromise * pregnancy
multi-session anodal cerebellar transcranial direct current stimulation (tdcs) vs anodal cerebral tdcs

Conditions: Stroke

Summary: to investigate which one of the two cerebellar and cerebral stimulation in comparison to sham stimulation is more effective in enhancing balance and postural stability in stroke patients


Eligibility criteria:
inclusion criteria: * the study focused on individuals who had their first stroke, * additionally, participants needed to have a score of 6 or higher on the johns hopkins fall risk assessment tool (jhfrat). * the inclusion criteria mandated that participants must have the ability to give written consent, walk without any help, and * have a functional condition that allows them to actively participate in the biodex balancing training program. exclusion criteria: * individuals with concurrent neurological problems such as alzheimer's, parkinson's, or cerebellar abnormalities, * as well as those with psychological ailments, were excluded during the initial assessment phase. * in addition, individuals who scored below 20 on the mini mental status examination test (mmse), * displayed motor disorders that affected their ability to walk or use their lower limbs, * were currently taking sedative medications, had amnesia, depression, radiculopathy, lumbar spinal cord root involvement, auditory or visual impairments, vertigo, recent fractures, severe cardiac problems, * or had undergone electrotherapy that affected their nervous system within the past two weeks were also not included in the study.
bay63-2521 - long-term extension study in patients with chronic thromboembolic pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: patients who have completed the 16 weeks treatment of the chest-1 trial (study number 11348) will be asked to participate in this long term extension study with bay63-2521. the aim of the long term study is to collect additional information to evaluate the safety and tolerability of bay63-2521. patients will be treated with open label medication on their individual optimal dose between 0,5 mg - 2,5 mg tid.


Eligibility criteria:
inclusion criteria: * patients who have completed 16 weeks of treatment in the double blind trial chest 1 exclusion criteria: * patients who have an ongoing serious adverse event from chest 1 that is assessed as related to bay63-2521 are not allowed to participate in the extension trial

Keywords: chronic thromboembolic hypertension ph soluble guanylate cyclase stimulator sgc
a phase i study of mgcd0103 given three-times weekly in patients with leukemia or myelodysplastic syndromes

Conditions: Leukemia; Myelodysplastic Syndromes

Summary: in this study, mgcd0103, a new anticancer drug under investigation, is given three times weekly to patients with leukemia or myelodysplastic syndromes.

phase i dose escalating study.

Eligibility criteria:
inclusion criteria: * patients must have a diagnosis of one of the following: * relapsed or refractory aml or all that has failed to respond to standard therapy, has progressed despite standard therapy * relapsed or refractory myelodysplastic syndromes * previously untreated aml or myelodysplastic syndromes in patients \> 60 years of age who refused or are not candidates for induction chemotherapy * patients with relapsed or refractory cml that has failed to respond to imatinib therapy or standard therapy, has progressed despite standard therapy, or for which no standard therapy exists * ecog performance status of 0, 1, or 2 * age ≥ 18 years * patients or their legal representative must be able to read, understand, and sign a written informed consent (approved by the irb/ec) prior to study entry exclusion criteria: * patients with a history of another cancer other than basal cell carcinoma or cervical intraepithelial neoplasia * pregnant or lactating women * patients and their partners, if either are of childbearing potential, not using adequate birth control measures throughout the study and for 90 days following the last dose of study medication * patients with known meningeal metastasis(es) * patients with active or uncontrolled infections, or with a fever \>38.5 c * patients with serious illnesses, medical conditions, or other medical history, which would be likely to interfere with a patient's participation in the study * patients who have been treated with any investigational drug or anti-cancer therapy within 30 days of study start.

Keywords: leukemia myelodysplastic syndromes phase i
role of elastography in diagnosis of testicular tumors

Conditions: Testicular Cancer

Summary: the aim of study is to differentiate between testicular tumors by their elastographic criteria (stiffness \[hard to soft\] , shape under compression , etc.) using ultrasound elastography techniques (shear wave/strain elastography) on suspected testicle that showed specific lesion on normal ultrasound examination.

technique: using a linear ultrasound probe supporting elastography techniques, either : strain elastography (se) se measures tissue stiffness by applying external tissue pressure \[3\]. tissue dimensions change due to the applied pressure; this deformation is termed strain. stiffer lesions deform less, and have correspondingly lower strain and higher young's modulus. in strain imaging, tissue displacement is calculated by processing radiofrequency (rf) datasets obtained before and after compression \[4\]. translucent colored elastograms (strain images) can be superimposed on b-mode images to provide complementary anatomic information. it is common to display the strain map as colored pixels on a red/blue scale or gray scale \[5\]. or shear wave elastography (swe) shear wave elastography differs from strain elastography, as it is a quantitative method of assessing tissue elasticity by measuring the speed of acoustic radiation force impulse-induced shear waves traveling in the tissue of interest. the compressive acoustic waves used for conventional b-mode image generation travel at high speeds through soft tissue (1450-1550 m/s). by contrast, mechanical shear waves used for shear wave elastography travel relatively slowly (1-10 m/s). shear wave propagation velocity depends on tissue stiffness \[2, 4\]. data collection: data will be recorded as excel spreadsheet and statistical analysis using spss software version 22 computer software: spss version 22 statistical software. statistical tests: t-test.

Eligibility criteria:
inclusion criteria: * i. age : (15-65 years). * ii. patient with history of testicular pain or discomfort or even without clinical symptoms. * iii. patient with any predisposing factors as mentioned before in the background. * iv. patient with history of cancer of other organs (not testicular tumors). exclusion criteria: * i. patient refused to be included in the study. ii. infarct correlation with patient history and symptoms is important. iii. infections as focal orchitis. iv. history of trauma (hematoma exclusion).