Kornimate/medical-research-clean huggingface dataset:
a french cohort of transplant recipients with cmv infection : risk factors for antiviral resistance in the prophylaxis era.

Conditions: Transplant Recipients With CMV Infection

Summary: resistance to antivirals is a growing problem in transplantation.that may concerns up to 5% of patients treated for cytomegalovirus (cmv) syndrome or disease in recent per-protocol studies. this prevalence vary with the organ transplanted and the degree of viral replication and immunosuppression. less data are available to date from real-life cohorts of patients, and there is no systematic survey of resistance in europe or in the us. non response to treatment concerns a larger group of patients and can result either from emergence of a resistant strain (virological resistance), from inadequate dosage of antivirals, or a high degree of immunosuppression, with a poor cmv immune response. the respective clinical impact of virological resistance and clinical resistance (of pharmacological or immunological origin) on graft outcome and long-term survival of patients has never been assessed. high viral loads and persistent replication associated to prolonged exposure to antivirals are known to favor the emergence of resistant strains. though epidemiology of resistant strains, role of multiple infections, impact of various mutations on degree of resistance to antivirals and outcome remains to be further studied. most studies are per-protocol studies or short-term studies conducted on limited populations. there are no data in real-life of transplanted patients at the era of enlarged prophylaxis except those from the french survey for cytomegalovirus resistance cohort opened at the end of 2006. from the first data collected on 346 patients we shown a 10,6% prevalence of non-response to therapy with 5,2% of virological resistance (6,1% incidence at one year on 214 patients) with a trend to poorer outcome in case of virological resistance and to the absence of impact of prophylaxis versus preemptive therapy, though larger populations and prolonged follow-up are requested to fulfill all objectives. we therefore aim to constitute a prolonged survey cohort for cmv resistance with a large number of patients and a prolonged follow-up, to gather data on resistance to antivirals in real-life of transplant patients in an organized data bank, this cohort is in the continuum of our previous cohort started in 2006, granted by the hospital clinical research program interregional (phrc), with the same major objectives and prolonged follow-up of patients.


Eligibility criteria:
inclusion criteria: * allograft recipient with active cmv infection, * or patient from the previous cohort, without opposition to biological collection of samples exclusion criteria: * not willing to participate, no health insurance

Keywords: transplantation cmv infection antiviral resistance
factors and prognostic significance of impaired exercise tolerance in women over 40 with arterial hypertension

Conditions: Arterial Hypertension; Heart Failure

Summary: the subject of the study is evaluation of factors affecting to exercise intolerance in spiroergometry in women over 40 years of age with hypertension and association and relationship between the parameters of physical performance and prognosis in this group of patients.

the 185 women over 40 years of age hospitalized for arterial hypertension in the department of cardiology will be included in the study, including: the study group who demonstrated maximal oxygen consumption measured during incremental exercise indexed per kilogram - vo2max\ 17 ml/min/kg.selected prognostic factors will be analyzed, among others: demographic data of the patient, physical examination, symptoms, etiology and history of arterial hypertension, co-morbidities, results of selected laboratory tests, selected electrocardiographic and echocardiographic data, patient's cooperation with the doctor, treatment applied, parameters in the spiroergometric study, non-invasive assessment for central arterial pressure waveform analysis and body mass analysis.

Eligibility criteria:
inclusion criteria: * age equal to or older than 40 years * arterial hypertension (ha) diagnosed according to the 2018 european society of cardiology (esc) guidelines of ha \[1\] * current ha hospitalization exclusion criteria: * severe hypertension * diagnosis of heart failure or typical symptomatic heart failure * left ventricular ejection fraction (lvef) \<50% * documented: hyperandrogenism, hyperestrogenism, insulin resistance, premature ovarian failure, polycystic ovary syndrome * past myocardial infarction * diagnosis of cardiomyopathy (hypertrophic, dilated, restrictive, peripartum, arrhythmogenic) * lysosomal storage disorders * stroke, transient ischemic attack, intracerebral hemorrhage in medical history * severe hyper- and hypothyroidism * pregnancy and lactation * chronic kidney disease (iv, v stadium according to national kidney foundation) and dialysis treatment * documented neoplastic process * the patient's inability to cooperate and/or provide informed consent to participate in a research * alcohol and drug abuse * active autoimmune disease * treatment using immunosuppressants, cytostatic drugs, glucocorticosteroids, or antiretroviral drugs * a history of bone marrow transplant or other organ transplant, treatment with blood products within the last 6 months * active systemic infection * hepatitis b virus (hbv), hepatitis c virus (hcv) or human immunodeficiency virus (hiv) carrier or positive for hepatitis b surface antigen (hbsag) or antibodies to hcv * surgery or serious injury within the last month * patients who did not express their informed consent to participate in the study

Keywords: hypertension exercise intolerance troponin body mass compartments
survey of brigatinib used to treat people with non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer (NSCLC)

Summary: this study is a survey in japan of brigatinib tablets used to treat japanese people with non-small cell lung cancer. the study sponsor will not be involved in how the participants are treated but will provide instructions on how the clinics will record what happens during the study. the main aim of the study is to check for side effects related to lung disease from brigatinib. during the study, participants with non-small cell lung cancer will take brigatinib tablets according to their clinic's standard practice. the study doctors will check for side effects from brigatinib for 1 year.


Eligibility criteria:
inclusion criteria participants with unresectable advanced/recurrent alk fusion gene-positive non-small cell lung cancer. exclusion criteria participants who has a history of hypersensitivity to any component of birigatinib.
building physician resiliency through creation health: a research study

Conditions: Burnout; Stress; Well-being

Summary: the purpose of this study is to determine whether a standardized application of a physician-oriented creation health curriculum is associated with reductions in burnout and perceived stress and improvements in well-being and empathy

this is a prospective, non-randomized study of a convenience sample of centura health physicians.this study will not include any drugs or devices. the physician-oriented intervention will consist of a two-day weekend retreat that focuses on the application of creation health principles in order to reduce burnout and perceived stress and improve well-being and empathy. there will be one four-hour session about each of the following creation health principles: choice, trust, interpersonal relationships, and outlook.

Eligibility criteria:
inclusion criteria: * physician employed by centura health or credentialed physician with privileges at centura health * adult ≥ 18 years old * english language proficiency * able to provide informed consent * resides in the denver, colorado area * willing to commit to the timeline of the study exclusion criteria: * plans to reside outside of the denver, colorado area within the 8 months
afferent neurocardiac signals, cue reactivity, and cognitive control

Conditions: Binge Drinking

Summary: conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors. the current study will examine whether a brief behavioral intervention of slow breathing paced at a resonance frequency of the cardiovascular system can interrupt automatic alcohol cue reactivity and enhance cognitive control in binge drinkers. results from the proposed study may provide new prevention and intervention targets to interrupt unhealthy drinking behaviors.


Eligibility criteria:
inclusion criteria: * must report at least 2 binge drinking episodes in the past month * have normal or corrected-to-normal vision exclusion criteria: * history or presence of serious psychiatric disorders, neurological disorders, or head injury resulting in a loss of consciousness * presence of any serious medical condition * report of more than a few occasions (3-4) of illicit drug use, except for cannabis, in the preceding year

Keywords: alcohol consumption baroreflex arousal breathing cardiovascular system cognition electrophysiology event-related potentials heavy drinking attention individual differences alcohol cue brief intervention cognitive control cue reactivity drinking behavior young adult heart rate variability
nmda-enhancing agent for treatment of mild cognitive impairment and mild alzheimer's disease

Conditions: Alzheimer's Disease; Mild Cognitive Impairment

Summary: nmda activation plays an important role in learning and memory. nmda receptors were found to decrease in the frontal lobe and hippocampus of alzheimer's disease and mild cognitive function impairment. this study is a randomized, double-blind, placebo-controlled drug trial. all patients will be allocated randomly to 2 groups: (1) nmda enhancer: daoi-b group (starting dose: 250-500 mg/d); (2) placebo group. the study period is 24 weeks. the investigators hypothesize that daoi-b may yield better efficacy than placebo for cognitive function in patients with mild cognitive impairment or mild alzheimer's disease.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild cognitive impairment or mild alzheimer's * mmse between 17-26 * cdr 0.5 or 1 exclusion criteria: * hachinski ischemic score \> 4 * substance abuse/dependence * parkinson disease * epilepsy * major depressive disorder * dementia with psychotic features * major physical illnesses * severe visual or hearing impairment

Keywords: alzheimer's disease mild cognitive impairment nmda
the effect of emotion regulation training on anxiety, in college students in egypt

Conditions: Anxiety; Emotion Regulation

Summary: the important role of emotion regulation (er) in managing stress and anxiety is well recognized. aims: 1) assessing the level of anxiety, and the level of difficulties in emotion regulation (der) among university students during covid-19, 2) investigating the effect of the emotional regulation training program on the anxiety of university students during the covid-19. methods: part i, students will be assessed for their anxiety, der, and the general impact of covid-19 on their lives. the students will complete beck anxiety inventory (bai) and difficulties in emotion regulation scale (ders). part ii will be a randomized control trial (rct) using a pre-assessment and a post-assessment. a voluntary sample of students will randomly assigned to either a group that will receive emotion regulation training or a control group. the training program is an adapted version of dbt skills training. the training program will include mindfulness, emotion regulation, and problem-solving skills through eight 90- min group sessions.


Eligibility criteria:
inclusion criteria: * being an active student at the university exclusion criteria: 1. receiving treatment at the hospital during the time that the study was in progress 2. having been diagnosed with psychotic disorders 3. having mental retardation

Keywords: university's students covid-19
fentanyl and crushed ticagrelor in percutaneous coronary intervention

Conditions: Percutaneous Coronary Intervention

Summary: during a percutaneous coronary intervention (pci), fentanyl is commonly used for sedation. ticagrelor is also routinely used as anti-platelet agent during pci. however, a recent study has demonstrated the decrease in effectiveness of ticagrelor when administered along with fentanyl. hence this study was designed to further assess the interaction between crushed vs non crushed ticagrelor and fentanyl given during pci procedures.


Eligibility criteria:
inclusion criteria: * undergoing clinically indicated elective or non-elective pci * able to swallow oral medications exclusion criteria: * contraindications to ticagrelor or fentanyl (or other opiates) * pregnancy * any use of p2y12 inhibitors within 14 days * known coagulation disorders * pre-procedural treatment with an anticoagulant (oral anticoagulant or low molecular weight heparin) * platelet count \< 100,000/mm3 * impaired renal function (estimated glomerular filtration \< 45 ml/min/1.73 m2) * impaired hepatic function (based on medical history) * prior or planned transcatheter aortic valve replacement
prucalopride in postoperative ileus

Conditions: Postoperative Ileus; Colorectal Surgery; Postoperative Complications

Summary: postoperative ileus (poi) refers to the period of gut dysmotility that occurs after abdominal surgery. patients with poi are unable to eat, suffer ongoing nausea and vomiting, are unable to open their bowels and have a prolonged hospital stay. research at adhb shows that 25% of patients will have a prolonged poi after elective bowel resection, which makes it the most common major complication after colorectal surgery. clinicians currently lack a definitive medication to prevent or treat poi, which means poi causes patients ongoing morbidity and places a significant drain on healthcare resources. serotonin plays an important role in gut motility. evidence suggests that serotonin agonists, such as prucalopride, increase gut transit and may have anti-inflammatory properties. the hypothesis of this study is that prucalopride given pre-operatively and continued post-operatively in patients having an elective bowel resection will improve gut function recovery after surgery and reduce poi. the investigators' proposed study is a double-blinded randomised controlled trial of prucalopride compared to an identical placebo tablet, in patients having an elective bowel resection at auckland city hospital. patients will receive a single tablet of prucalopride or placebo 2-3 hours preoperatively and then daily after operation for a maximum of 6 days. the primary endpoint will be return to bowel function defined by the time to tolerate a solid diet and pass stool. in addition, the investigators plan to assess postoperative gastric emptying rates using the safe and non-invasive carbon breath test method. this will allow the investigators to determine the effects of prucalopride on the stomach, and support its role as a gastric prokinetic.


Eligibility criteria:
inclusion criteria: * adult patients from auckland district health board catchment * age 18 or older * elective and subacute surgery * right hemicolectomy, left hemicolectomy, sigmoid colectomy, anterior resection, hartmann's procedure, subtotal colectomy * operation with or without the formation of a colostomy * indication for operation: colon cancer, diverticular disease, gynaecological * able to understand risks and benefits of the study * able to give informed consent exclusion criteria: * asa 4 or greater * allergy to any serotonin medication * active inflammatory bowel disease * planned formation of an ileostomy during surgery * moderate to severe renal impairment (creatinine clearance\<50ml/min/1.73m2) * severe hepatic impairment (child-pugh c) * pregnancy * pre-existing gut dysmotility disorder including endocrine, metabolic or neurological cause * pre-operative malnutrition requiring parenteral nutrition * inability to give consent or participate in post-operative assessments due to dementia, cognitive impairment, language difficulties, delirium
factors of control hypertension or type 2 diabetes on the severity of stroke and survival rates within 1 year in trat

Conditions: Stroke; Hypertension; Type2diabetes

Summary: the purpose of this study was to study factors for controlling hypertension or type 2 diabetes before stroke diagnosis on the severity level when a stroke occurs, nihss, and survival rate after having a stroke in 1 year in trat province the research hypothesis was patients with hypertension or type 2 diabetes who are well-controlled will have a lower nihss score than the group whose disease is not well-controlled. and patients with hypertension or type 2 diabetes that is well controlled there will be a higher survival rate for patients diagnosed with cerebrovascular disease within 1 year than those whose disease cannot be controlled.

background: situation of non-communicable disease groups. it was the number one health problem in the world. the situation in thailand from 2017-2022 found an increase in the number of new diagnoses and death cases from stroke patients. for the situation in trat province, it was found that the situation of sickness rates tend to be stable. as for the death rate per 100,000 people from stroke, there was a continuous upward trend. therefore, a research project was organized to study the factors of control disease (hypertension or non-insulin-dependent diabetes mellitus type 2) on the severity of stroke and survival rates within 1 year to be used as information for further patient care. objectives: to study factors that influence the severity of stroke and correlate with survival rates within 1 year in trat province. methods: this is a retrospective analytic cohort study. data was collected using a case record form (crf) to record information on a total of 291 cases of hypertension and non-insulin-dependent diabetes mellitus type 2 patients who entered the stroke treatment system at trat hospital in the year 2022. data were analyzed by chi-square statistics to test the relationship of ncd control with the severity of stroke and using kaplan-meier curve test hypotheses for comparing survival rates using log-rank test statistics.

Eligibility criteria:
inclusion criteria: * patients who have chronic hypertension or type 2 diabetes with a history of illness of at least 1 year before the stroke. * patients had a new stroke for the first time in his life, including an ischemic stroke. hemorrhagic stroke and hemorrhage in the brain * the patient was confirmed by ct scan * thai nationality. exclusion criteria: * patients diagnosed with cerebrovascular disease who have a previous history of ischemic or hemorrhagic stroke. * patients diagnosed with transient ischemic attack * patients who have a history of chronic disease that are at high risk of having a stroke, such as being a pregnant patient, still taking birth control pills. * there are certain genetic diseases, such as antiphospholipid syndrome * patients had previous history of brain aneurysm, extracranial arterial dissection, atrial fibrillation, drug addict use, etc.

Keywords: national institute of health stroke scale
geriatric communication skills training program for oncology clinicians

Conditions: GI Cancer; Lymphoma; GU Cancer; Bone Marrow Transplant

Summary: the purpose of this study is to learn more about the effects of a training program designed to help doctors communicate better with older patients and their caregivers.


Eligibility criteria:
inclusion criteria: clinician eligibility * msk medical oncology health care professionals (hcp) - specifically identified as attendings, fellows, or advance practice professional (app) - either a nurse practitioner (np) or physician assistant (pa) from gi, gu oncology, lymphoma, bone marrow transplant or geriatrics service (five services with a large number of geriatric patients) * willingness to be audio-recorded as per self-report * clinician has individual clinic consultations with patients in the target population: 65 years of age and over, english speaking, and patients who have had a new visit within the last 6 months. patient eligibility * msk patients 65 years of age and over as per emr * english speaking as per emr * being seen by one of the consented hcps as per the hcp and/or electronic medical record (emr) * willingness to be audio-recorded as per self-report * patient had their first visit with the clinician within the last 6 months caregiver eligibility * english speaking as per emr * accompanying an msk patient being seen by one of the consented hcps as per the hcp and/or emr exclusion criteria: * n/a
pergolide treatment for substance abusers - 4

Conditions: Cocaine-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is to evaluate the safety and efficacy of pergolide for cocaine dependence.


Eligibility criteria:
please contact site for information.

Keywords: cocaine dependence
exceptional experiences (ee), salience & dopaminergic neurotransmission

Conditions: Healthy; Schizotypal Personality

Summary: the dopamine hypothesis of schizophrenia implies that alterations in the dopamine system cause functional abnormalities in the brain that may converge to aberrant salience attribution and eventually lead to psychosis. indeed, widespread brain disconnectivity across the psychotic spectrum has been revealed by resting-state functional magnetic resonance imaging (rs-fmri). however, the dopaminergic involvement in intrinsic functional connectivity (ifc) and its putative relationship to the development of psychotic spectrum disorders remains partly unclear - in particular at the low-end of the psychosis continuum. therefore, the investigators examined dopamine-induced changes in striatal ifc and their modulation by psychometrically assessed schizotypy. the randomized, double-blind placebo-controlled study design included 54 healthy, right-handed male participants. each participant was assessed with the schizotypal personality questionnaire (spq) and underwent 10 min of rs-fmri scanning. participants then received either a placebo or 200 mg of l-dopa, a dopamine precursor. the investigators analyzed ifc of six striatal seeds that are known to evoke modulation of dopamine-related networks. the investigators hypothesized that, within the l-dopa treatment group, the striatal ifc would be disrupted due to increased availability of dopamine. the investigators further hypothesized that individuals with high schizotypal scores would show a disruption of striatal connectivity, as has been reported with schizophrenia. in addition, the investigators hypothesized that the l-dopa-dependent change in striatal ifc would interact with the severity of positive symptoms, as has been found in previous studies in non-clinical psychosis. the investigators anticipated this symptom-dependent change, especially in the ventral striatal regions, because these are thought to modulate cortico-striatal loops associated with cognition and emotion.


Eligibility criteria:
inclusion criteria: * healthy, * between 20 and 40 years of age, * with exceptional experiences or skeptics, * caucasian origin, * normal visual and acoustic accuracy. exclusion criteria: * persons with a personal or first-degree family history of neurological and psychiatric disease, including impaired cognitive abilities, * pregnant or breastfeeding women, * chronic or acute pain, * acute or chronic somatic disease, * women (i.e. only men included), * men over 40 years of age or below 20, * left- or mixed-handedness, * general mri exclusion criteria, * general dopamine-challenge exclusion criteria, * hormonal or herbal therapy, * smoker.

Keywords: resting-state functional mri dopamine functional connectivity