Kornimate/medical-research-clean huggingface dataset:
mast trial: multi-modal analgesic strategies in trauma

Conditions: Nonspecific Pain Post Traumatic Injury

Summary: this is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. two different multi-modal, opioid minimizing analgesic strategies will be compared \[original multimodal pain regimen (mmpr) compared to multi-modal analgesic strategies for trauma (mast) mmpr\].


Eligibility criteria:
inclusion criteria: * all patients admitted to the trauma service who are 16 years and older. exclusion criteria: * pregnant * prisoner * patients placed in observation (i.e. not admitted to the hospital)
home-based pulmonary rehabilitation and health coaching in patients with fibrotic interstitial lung disease

Conditions: Lung Fibrosis; Lung Interstitial Disease

Summary: the purpose of this clinical trial is to determine the impact of a home-based pulmonary rehabilitation program with health coaching on patient-reported respiratory-related quality of life and physical activity, as compared to usual care in patients with fibrotic interstitial lung disease.

the fibrotic interstitial lung diseases (f-ild) are a group of progressive and debilitating lung diseases sharing characteristics of lung scarring on imaging and restricted breathing on pulmonary function testing (pft). symptoms include shortness of breath, cough, and fatigue, eventually leading to deconditioning and poor quality of life. while medical therapies are available for slowing or stopping the loss of lung function, only pulmonary rehabilitation (pr) has shown a positive impact on patient-reported shortness of breath and physical activity. unfortunately, pr may not be widely available to all patients, and some patients may become too ill to participate in traditional center-based programs. a primary hypothesis is that modifying the content, delivery, and setting for pr in patients with f-ild to improve access or ease of use and supporting behavior change through a health coach will have a measurable and sustained positive impact on patient well-being and quality of life as compared to no participation or non-use.

Eligibility criteria:
iinclusion criteria: * f-ild diagnosis, any disease subtype, active or prior medical treatment * \>10% fibrosis on ct imaging * mmrc dyspnea score \>1 * all racial or ethnic categories, including non-english speakers (professional translators will be engaged to support screening, enrollment, and study participation) exclusion criteria: * inability to walk (orthopedic/neurologic/cardiac limitation causing immobility) * cognitive impairment or inability to understand and follow instructions * traditional center-based pr completed within 3 months of initial study recruitment * transition to hospice or end-of-life care at the time of screening * acute exacerbation at the time of screening
the effects of topical haemoglobin spray in pressure ulcer

Conditions: Pressure Ulcer; Wound Heal

Summary: a prospective randomised controlled experimental study was planned to compare the effects of pressure sore dressing using topical haemoglobin and traditional gauze dressing using saline on the healing process and cost of pressure sores in patients with pressure sores.

pressure sores are a serious health problem because they increase mortality, decrease quality of life, prolong hospital stays, increase patient care costs, impair body image, prolong the healing process, and have many other negative effects. the european pressure ulcer advisory panel (epuap), national pressure ulcer advisory panel (npiap), and pan pacific pressure ulcer association (pppia) 2019 guidelines report that the prevalence of pressure ulcers in healthcare settings ranges from 10% to 72.5%, with large variations between different clinics and geographies. in the united states, the cost of pressure sore treatment to organisations is estimated to be $11 billion annually. pressure sores will continue to be an important public health problem today and in the future, especially due to the increasing number of elderly people in the world and in our country, chronic diseases, comorbidity, and palliative conditions. therefore, the study was planned as a prospective randomised controlled experimental trial to compare the effects of pressure sore dressing using topical haemoglobin and traditional gauze dressing using saline on the healing process and cost of pressure sores in patients with pressure sores.

Eligibility criteria:
inclusion criteria: 1. be over 18 years of age, 2. normal albumin and protein levels, 3. stage 2 pressure ulcer, 4. blood glucose level is within normal limits, 5. the consent of the patient himself or his guardian. exclusion criteria: 1. being under 18 years of age, 2. pressure ulcers in areas other than the sacrum, 3. stage 1, stage 3, stage 4, unstageable pressure ulcers, 4. albumin and protein values are lower than normal, 5. blood glucose level is not within normal limits, 6. the patient himself/herself or his/her guardian does not authorise it.

Keywords: pressure ulcer nursing care topical haemoglobin spray wound dressing
svt-40776 in patients suffering from overactive bladder syndrome

Conditions: Overactive Bladder (OAB)

Summary: the study will examine which dose of svt-40776 is best in terms of efficacy, safety and tolerability compared to placebo and tolterodine


Eligibility criteria:
inclusion criteria: * patients suffering from oab for at least 6 months prior to inclusion exclusion criteria: * pregnant and breastfeeding women * any medical condition or need for co-medication which interferes with the drug under investigation (svt-40776) or the comparator (tolterodine)
efficacy and safety of mk0928 for insomnia in adults (0928-003)(completed)

Conditions: Insomnia

Summary: the purpose of this trial is to study the safety and effectiveness of mk0928 for adults with insomnia.


Eligibility criteria:
inclusion criteria: * diagnosis of insomnia
study on effectiveness of 2-dose live attenuated varicella vaccine

Conditions: Varicella

Summary: the objective of the study is as follows: 1. to know the antibody level during different interval after received 1 dose varicella vaccine. 2. to know safety and effectiveness of received 2 doses varicella vaccine with different interval. 3. to know safety and effectiveness of received varicella vaccine and mmr at the same time. to achieve that, this study selects children with specific varicella vaccine history, gives 1 or 2 doses varicella vaccine, collects blood specimens and makes a follow-up visit after vaccination. all blood specimens will be tested by a third-party detection institution.


Eligibility criteria:
inclusion criteria: * aged 1 to 7 * without a previous history of varicella * with an axillary temperature ≤37.5℃ at the time of vaccination * appropriate varicella vaccination history * with guardian signing the informed consent and available for clinical observation exclusion criteria: * hypersensitive to any active substance of the vaccine including excipients and antibiotics * with acute illness, severe or acute attack of chronic illness or fever * with immunodeficiency or weakened immune system or being treated with immunosuppressant drugs * suffering a brain disease, uncontrolled epilepsy or progressive nerve system disease * with a family or personal history of seizure, chronic illness, epilepsy or allergy * with unknown immunization history or unable to follow the immunization schedule of epi * received any vaccine within 4 weeks or willing to receive any vaccine in 1 month * with hemorrhagic tendency or prolonged period of bleeding * received whole blood, plasma or immunoglobulin within 5 months * received systemic antibiotics or antiviral treatment for acute illness within 7 days * with an axillary temperature ≥38℃ within 3 days * participating in another clinical trial * any situation that might influence the consequence of the clinical trial

Keywords: varicella vaccination
effectiveness of two treatments on posture and balance in elderly women with osteoporosis

Conditions: Osteoporosis

Summary: the purpose of this study was compare the efficacy of two exercise programs - the first consisting of balance training and muscle strength and the second consisting of balance training and muscle stretching exercises - to improve postural control in elderly women with osteoporosis.

the decrease in postural control and muscle strength in lower limbs have been identified as major risk factors for falls in older people. exercises have proven effective in decreasing risk factors in healthy elderly, but little is known about the effects of interventions with exercise in the elderly with osteoporosis. objective: to compare the efficacy of two exercise programs - the first consisting of balance training and muscle strength and the second consisting of balance training and muscle stretching exercises - to improve postural control in elderly women with osteoporosis. methods: fifty elderly aged 65 or older, with a diagnosis of osteoporosis, were randomized into 3 groups: strength group (n = 17) performed balance training with muscle strengthening; stretching group (n = 17) performed balance training with stretching; and control group (n =16) did not do activity. the groups trained for 8 weeks, with sessions of about 60 minutes, twice a week. postural control was evaluated by modified clinical test of sensory interaction for balance (ctsibm) and limits of stability test (los) in balance master force plate, the functional balance by berg balance scale (bbs), muscle strength by dynamometry, the shortening of the hamstrings by goniometry and posture by pas/sapo (postural assessment software).

Eligibility criteria:
inclusion criteria: * women from 65 to 80 yrs of age * diagnosis of osteoporosis classified according to the criteria of the world health organization, with bone mineral densitometry reduced by at least 2.5 sd when compared with young adults (region of lumbar spine) exclusion criteria: * severe visual deficiency * physically incapable of participating in the tests * neurological disorders, amputations, or prostheses * individuals with regular physical activity (twice or more per week) or who had recently participated in exercise programs for muscular strength or balance

Keywords: elderly postural balance musculoskeletal equilibrium posture muscle strength muscle stretching exercises
study of clostridioides difficile in infants

Conditions: Clostridioides Difficile Infection

Summary: clostridioides difficile infection (cdi) poses an increasing threat to infant and young child health, with detection rates rising annually. this retrospective study aims to explore the epidemiological characteristics, clinical manifestations, and potential biomarkers of cdi in children aged 0-2 years by examining three cohorts: (1) infants diagnosed with cdi, (2) asymptomatic carriers of c. difficile, and (3) healthy controls. fecal samples from each group will undergo metagenomic sequencing and metabolomic profiling, coupled with questionnaire-based surveys for risk factor assessment. the findings are anticipated to identify key high-risk factors, elucidate the pathogenic mechanisms underlying infant cdi, and support the development of early diagnostic tools and preventive strategies.


Eligibility criteria:
inclusion criteria: 1. age range: infants aged 0 to 2 years (inclusive) at the time of sample collection or medical record documentation. 2. data availability: complete medical records or available stool samples within the study's retrospective time frame. 3. group-specific criteria: cdi patients: documented diarrhea or related gastrointestinal symptoms, with laboratory-confirmed c. difficile by pcr or culture. asymptomatic carriers: positive c. difficile test (pcr or culture) in the absence of diarrhea or other clinical cdi symptoms. healthy controls: negative c. difficile test and no gastrointestinal symptoms indicative of cdi. 4. consent/authorization:retrospective data (e.g., existing medical records or stored biosamples) may be included under a waiver of consent if approved by the institutional review board (irb). however, any new information obtained directly from participants or their guardians (e.g., via questionnaires) requires explicit informed consent. exclusion criteria: 1. incomplete data: infants whose medical records lack sufficient information to confirm their cdi status or those without adequate stool sample results. 2. ambiguous diagnosis: patients presenting with other infectious diseases or conditions that could not rule out alternative diagnoses for diarrhea (e.g., confirmed concurrent viral or parasitic infections) without conclusive c. difficile testing. 3. severe comorbidities: infants with life-threatening congenital conditions (e.g., severe immunodeficiency syndromes) if these conditions significantly alter the gut microbiota or confound cdi diagnosis.

Keywords: clostridioides difficile infants
molecular profile of thyroid nodules

Conditions: Thyroid Cancer; Thyroid Nodule

Summary: profiling and comparative analysis of genomic alterations and mirna expression in benign and malignant thyroid tumors using histological and cytological specimens will be performed. obtained information is necessary to create a molecular test to refine the cancer risk of cytologically indeterminate thyroid nodules.

this is an non-randomised retrospective study consisting of 2 parts. part a. histological specimens (formalin fixed paraffin embedded) of patients who were operated on for benign and malignant thyroid disorders will undergo molecular testing to create a molecular profile of thyroid nodules characteristic of belarusian population. part b. fixed cytological smears of indeterminate thyroid nodules (categories iii, iv and v according to bethesda scoring system) of operated patients will undergo molecular testing to evaluate the possibility and reliability of molecular testing of fixed cytological smears using available assays.

Eligibility criteria:
inclusion criteria: patients operated on for malignant and benign thyroid tumors. age is greater than or equal to 18 years old. exclusion criteria: no

Keywords: thyroid cancer thyroid nodule mirna molecular testing
effects of peritendinous corticosteroid injections, eccentric training and heavy slow resistance training in patellar tendinopathy

Conditions: Patellar Tendinopathy / Jumpers Knee

Summary: we will investigate the effect of peritendinous corticosteroid injections, eccentric training and heavy resistance training in male patellar tendinopathy patients. the purpose is to compare the clinical effect of these three treatments in a randomised controlled trial. also we wish to investigate the treatment mechanisms responsible for the effectiveness of the three treatments.

3 interventions groups as described above (n=13 in each group) 12 weeks intervention period. clinical assessments before and after intervention: vas, visa, tendon thickness, doppler us activity. before and after intervention tendon biopsies will be taken and analyzed for crosslinks and fibril diameter. also tendon mechanical properties will be measured. tendon and muscle structural properties will be measured with mri. treatment satisfaction will be stated after intervention period.

Eligibility criteria:
inclusion criteria: * clinical patellar tendinopathy pain. * tendon swelling * hypoechoic * doppler activity in tendon exclusion criteria: * previous knee surgery * diabetes * arthritis * previous steroid injections
phase 2 study of adx-038 in participants with geographic atrophy

Conditions: Geographic Atrophy Secondary to Age-related Macular Degeneration

Summary: phase 2 study is designed to assess the efficacy of adx-038 compared with placebo in participants with ga secondary to amd. safety, pharmacokinetics (pk), and pharmacodynamics (pd) will also be assessed.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ga of the macula secondary to amd * ga lesions between 2.5 and 12.5 mm2 at screening * sufficiently clear ocular media, adequate pupillary dilation and fixation to permit quality fundus imaging in the study eye as described in the protocol * willing and able to comply with clinic visits and study-related procedures, including completion of the full series of meningococcal vaccinations and pneumococcal vaccination required per protocol exclusion criteria: * has ga secondary to causes other than amd * has active ocular disease that compromises or confounds visual function * history of surgery for retinal detachment * has ocular condition other than ga secondary to amd * use of intravitreal complement inhibitors in study eye * hereditary or acquired complement deficiency * active viral, bacterial or fungal infection * liver injury as evidenced by abnormal liver function tests * donating blood * history of choroidal neovascularization in the study eye
clinical outcomes in patients with infection by resistant microorganism

Conditions: Pneumonia; Bloodstream Infection; Urinary Tract Infections; Skin Infection; Surgical Site Infection; Staphylococcus Aureus; Klebsiella Pneumonia; Escherichia Coli; Enterococcus Faecium Infection; Acinetobacter Infections; Pseudomonas Aeruginosa

Summary: the goal of this individual patient data meta-analysis is to estimate the attributed and the associated health burden related to bloodstream infections, pneumonia, skin and soft tissue infections, surgical site infections and urinary tract infections, caused by target drug-resistant pathogens, in high income countries. the main question\[s\] it aims to answer are: * are common infections caused by drug-resistant pathogens associated with an increased health burden, when compared with individuals with the same infection caused by a susceptible strain (attributed burden)? * are common infections caused by drug-resistant pathogens associated with an increase health burden, when compared with individuals without the infection under study (associated burden)?


Eligibility criteria:
inclusion criteria: * individuals of all ages * individuals with hospital acquired, community acquired, or healthcare associated infections * individuals treated at hospital level, community, or long-term care facilities * individuals with the targeted pathogen, resistance phenotype, and infection site combinations under study exclusion criteria: * individuals with infections in the following systems: central nervous system, genital system, pelvic infections and head and neck infections * individuals with the following specific primary infections: endocarditis, upper respiratory tract infections, lung abscess * individuals with bacterial infections not included in the table of pathogens of interest, polymicrobial infections except for intraabdominal infections, fungal infections, parasitic infections, viral infections, mycobacterial infections, sexually transmitted diseases, and zoonotic infections
azithromycin dose and pprom treatment: a pilot randomized controlled trial

Conditions: Preterm Premature Rupture of Membrane

Summary: this is a pilot randomized controlled trial to assess the pharmacokinetics and pharmacodynamics of azithromycin in pregnant singletons admitted with preterm premature rupture of membranes (pprom) at 24 0/7- 33 0/7. participants will be randomized 1:1 to either 1000mg azithromycin orally once or 500mg azithromycin orally daily for seven days in addition to standard care.

this is a pilot randomized controlled trial to assess the pharmacokinetics and pharmacodynamics of azithromycin in pregnant singletons admitted with preterm premature rupture of membranes (pprom) at 24 0/7- 33 0/7. participants will be randomized 1:1 to either 1000mg azithromycin orally once or 500mg azithromycin orally daily for seven days in addition to standard care. during the course of eight days participants will have serial collection of amniotic fluid, maternal serum; and at delivery, of placenta, membrane, and cord blood. after delivery, neonatal respiratory samples will be collected as well.

Eligibility criteria:
inclusion criteria: * singleton gestation 24 0/7 -33 0/7 weeks' * diagnosed with preterm premature rupture of membranes: * history consistent with ruptured membranes (ie leaking, gush of fluid) * sterile speculum exam with pooling * fluid positive for ferning and/or nitrazine * with or without confirmatory test such as amnisure exclusion criteria: * • contraindication to azithromycin * active labor, abruption, chorioamnionitis at enrollment * other contraindication to expectant management of pprom at enrollment
efficacy of rehabilitation using action observation and muscle stimulation in post-stroke patients.

Conditions: Stroke; Stroke Sequelae

Summary: stroke is the third most common cause of disability worldwide and leads to upper limb motor disease in more than half of people affected. recent data demonstrate that upper limb rehabilitation can be pursued using techniques such as the observation of action (action observation therapy - aot) or the stimulation of limb musculature using surface electrodes (neuromuscular electrical stimulation - nmes). to date, no rehabilitation studies used both the treatments (aot-nmes) for the rehabilitation of upper limb after stroke. the goal of this clinical trial is to study the efficacy of this combined approach (aot-nmes) in people who developed upper limb motor impairment after stroke. the main question this study aims to answer is if the rehabilitation performed using both action observation and neuromuscular stimulation has an higher efficacy than the use of aot alone and higher than the observation of non-motor stimuli. participants will be people with upper limb impairment after stroke and will perform 15 rehabilitation sessions (5/week, 3 weeks, 60 minutes each). each participant will be casually included in one of following three rehabilitation groups: * action observation associated with neuromuscular stimulation (aot-nmes, experimental condition): they will observe upper limb movements while their arm muscles will be stimulated. after the observation phase they will try to perform the same movements with the impaired arm. * action observation alone (aot): subjects will observe upper limb movements and after the observation phase then they will try to execute them with the impaired arm. * motor-neutral observation (mno): subjects will observe non-movement videos and after the observation phase they will try to execute upper limb movements with the impaired arm. each participant will be evaluated for motor function before and after rehabilitation treatment and researchers will compare the motion improvement between the groups to assess the efficacy of aot-nmes over other treatments.


Eligibility criteria:
inclusion criteria: * age over 18 years; * upper arm motor impairment after unilateral stroke as verified by mri or ct; * two weeks up to 6 months after stroke; * grading of upper arm motor impairment\>2 at medical research council scale (mrc). exclusion criteria: * neurological/orthopedic issues that would interfere with upper limb exercises; * presence of any medical condition that represents a contraindication to magnetic resonance imaging (mri) examination or to transcranial magnetic stimulation (tms); * presence of dermatologic issues that will interfere with neuromuscular stimulator; * presence of electronic subcutaneous implants; * presence of peripheral neuropathy; * epilepsy; * pregnancy; * presence of severe cognitive impairment, including language comprehension detected during the neurological evaluation.