Kornimate/medical-research-clean huggingface dataset:
the effect of escitalopram in pcos

Conditions: Polycystic Ovary Syndrome

Summary: in a randomized study the investigators aim to characterize the effect of antidepressive medicine on quality of life, body composition, adrenal activity and glucose metabolism in pcos. pcos is a common endocrine disorder characterized by adrenal and ovarian hyperandrogenaemia, anovulation and insulin resistance. the pathogenesis of pcos may be described by a vicious cycle involving insulin resistance which stimulates ovarian and adrenal hyper androgenaemia and leads to abdominal obesity, causing increased risk for diabetes and cardiovascular disease. adrenal hyperactivity is associated with depression. antidepressive medicine may normalize pituitary-adrenal activity and in animal studies antidepressive medicine improved adrenal hyperactivity and normalized insulin sensitivity.

clinical study effects of antidepressive treatment on quality of life, insulin sensitivity and cortisone metabolism in pcos. hypothesis participants with pcos have increased hypothalamic-pituitary-adrenal activity compared to healthy women. antidepressive treatment improves quality of life, cortisone and glucose turnover. design a randomized controlled study in 40 pcos patients who are treated with cipralex or placebo for 12 weeks. before and after the treatment period the patients have a physical examination, a whole body dexa scan and fasting blood samples. hypothalamic-pituitary-adrenal is measured by 24 hour samples of cortisone metabolites, 60 minutes acth test with basal and stimulated measurement of cortisone and 17-hydroxyprogesterone. glucose metabolism is examined by oral glucose tolerance test. biopsies of muscle and fat are also performed.

Eligibility criteria:
inclusion criteria: * bmi \> 25 and \<5 * age 18-45 years * two of the following 1: an/oligomenorhea, 2: hirsutism or hyper androgenaemia, 3: pco in trans vaginal ultrasound * other diagnoses excluded exclusion criteria: * post menopausal * diabetes * eating disorder * psychiatric disorder * usage of oral anticonceptives or metformin * pregnancy or planned pregnancy in the treatment period * non-caucasian * epilepsy * allergy to the medicine
assessment of music experiences in navigating depression

Conditions: Depression

Summary: the study team sought to scientifically investigate strategic subsets of depressed individuals or people prone to or at-risk of depression through music experiences of individual, group, and blended supported contexts. meetings with the study multi-disciplinary team, included member of the carnegie hall weill music institute and university affiliates, where the study team gathered quantitative and qualitative data in individual and group forums, measuring disease process and levels of participation. through tabulation of participatory options with standardized depression and resilience measurements, the study team studied how live music could alter depressive symptoms over time and/or change negative influencers of mood, shift quality of life, and lead toward possibly enhanced disease trajectory outcomes.


Eligibility criteria:
inclusion criteria: * participants between the ages of 8-70 years with a clinical diagnosis of major depressive disorder (mod) who met the dsm-5 (2013) criteria for a major depressive episode, and/or who identify themselves, or are identified by family, or referring clinicians as depressed, or are prone to depression * depressive episodes and/or showing symptoms of mild to moderate depression intensity * self-reported satisfactory bilateral hearing * english or spanish language fluency sufficient to complete the interviews and questionnaires exclusion criteria: * axis i diagnosis, aside from mod, considered the primary diagnosis * bipolar disorder type i or ii, * axis ii diagnosis such as antisocial or borderline. * arrhythmia, * pacemaker * prolapsed vertebral disc, and * recent back or neck injuries.

Keywords: depression music assessment music therapy anxiety
a biological study of resveratrol's effects on notch-1 signaling in subjects with low grade gastrointestinal tumors

Conditions: Neuroendocrine Tumor

Summary: resveratrol has been shown to activate a protein called notch-1. signaling of notch-1 has been shown to prevent tumor cell growth. resveratrol has also been shown to prevent growth of tumors in mice. the purpose of this study is to examine the effects of resveratrol and notch-1 on neuroendocrine tumor tissue and to examine how people with neuroendocrine tumors who take resveratrol for up to three months tolerate the product.

patients will be treated with a dose of 5 gm/day of resveratrol orally, in two divided doses of 2.5 gm each without a break in therapy for a total of three cycles. all patients who receive at least one dose of resveratrol will be evaluated for toxicity and tolerability. toxicities will be assessed every 28 days while the study drug is being taken by the patient. pill bottles will be reviewed at this visit as well to ensure compliance with the study medication. toxicities will be graded according to the nci common toxicity criteria. blood will be drawn for a complete blood count and comprehensive metabolic panel. in addition, one vial of serum will be stored at the time of each toxicity assessment for later analysis of resveratrol levels. this level must be drawn one hour after the morning dose and the participants will be instructed to alter the time of the morning dose so as to allow proper timing with the scheduled blood draw. during the third cycle of treatment, a post-treatment biopsy will be obtained for study related purposes and will be processed only for research related purposes.

Eligibility criteria:
inclusion criteria: 1. ecog performance status of 0-2 2. age \>18 years old 3. women who are not postmenopausal must have a negative enrollment blood test and agree to use an effective mode of contraception while taking the study medication 4. greater than four weeks must have elapsed since any previous therapy was administered for the neuroendocrine tumor, including surgery, radiation, chemotherapy or local liver therapy. 5. octreotide use is allowed but must be initiated at least four weeks prior to enrollment and to the pre-treatment biopsy 6. able to give informed consent and willing to undergo the post-treatment research biopsy 7. must be able to take oral medications and be without gi tract obstructive symptoms 8. subjects with another malignancy for which they are either undergoing treatment with chemotherapy or radiation, or with a malignancy for which such treatments have been recommended, would be excluded or withdrawn from the study. 9. must agree to abstain from excessive alcohol, as defined by greater than the equivalent of three glasses of wine per day or one six pack of beer per day exclusion criteria: 1. the principal investigator will review each subject's current medications prior to enrollment of the study to ensure that the administration of resveratrol will not affect their current medications.

Keywords: gastrointestinal neuroendocrine tumor
neuroprotective effects of remote ischemic preconditioning (ripc) during infant cardiac surgery

Conditions: Heart Defects, Congenital

Summary: the purpose of this study is to look at whether the use of a simple technique before surgery, which involves inflating a blood pressure cuff on the infant's leg, can improve development of language, motor and thinking skills at 12 months of age. some research has found that a brief shortage of blood supply to an organ (such as a leg) at level that does not cause harm may help the body to tolerate a longer and more severe shortage of blood (for example, during surgery).

the purpose of this study is to look at whether the use of a simple technique before surgery, which involves inflating a blood pressure cuff on the infant's leg, can improve development of language, motor and thinking skills at 12 months of age. some research has found that a brief shortage of blood supply to an organ (such as a leg) at level that does not cause harm may help the body to tolerate a longer and more severe shortage of blood (for example, during surgery). neurodevelopmental assessment: the bayley scales of infant and toddler development, third edition (bayley-iii)9 assesses the developmental functioning of infants and young children between the ages of 1 month and 42 months. cognitive, language, and motor development are assessed through structured play activities. social-emotional and adaptive functioning are assessed through parent questionnaires. administration time is 45 - 60 minutes, depending on the child's performance and behavior. psychometric properties are well defined and acceptable. composite scores for cognitive, language, motor, social-emotional, and adaptive behavior are standardized with a mean of 100 and a standard deviation of 15. the infant development inventory (idi)10 will also be used to assess neurodevelopmental functioning, based on parent report. parents are asked to rate their child's developmental skills in five domains: social, self help, gross motor, fine motor and language. administration time is approximately 10 minutes. infants are categorized as delayed or not delayed for each of the five domains.

Eligibility criteria:
inclusion criteria: * infants \<7 months of age * undergoing open heart surgery * written informed consent exclusion criteria: * presence of known gross neurologic abnormality preoperatively * history of birth asphyxia * non-english speaking family

Keywords: remote ischemic preconditioning heart defects, congenital cardiac surgery neurodevelopmental outcomes
effects of hemofiltration and mannitol treatment on cardiopulmonary-bypass induced immunosuppression

Conditions: Inflammation

Summary: after cardiac surgery with cardiopulmonar bypass, the lps-stimulated cytokine response has been previously shown to be depressed. therefore, in this trial the hypothesis was tested, whether simple immunomodulting interventions like the i.v. adminstration of mannitol of hemofiltration during cardipulmonary bypass can attenuate this immunosuppressing effect.

background cardiac surgery using cardiopulmonary bypass (cpb) causes a systemic inflammatory response. in addition to this immune response to cpb, a significant impairment of the responsiveness of peripheral blood mononuclear cells (pbmc) to further immunological stimuli has been observed. the aim of our present study was to evaluate the ability of antioxidant therapy with mannitol or hemofiltration during cpb to modulate the observed immunosuppression after cpb. methods with ethics committee approval, 52 patients undergoing elective cabg-surgery were prospectively enrolled and randomized into 3 groups (control, 50 g mannitol iv, hemofiltration during cpb). blood samples were taken after induction of anesthesia (t1), 20 min after separation from cpb (t2) and 24 h postoperatively (t3). expression density of the monocytic surface receptor cd14, hla-dr expression and cytokine release (tnf- and il10) after lps-stimulation were evaluated. results at t2, the cd14dim cell population was maintained in both intervention groups while in the control group there was a significant decrease of this proinflammatory monocytic phenotype. at t3, all groups developed a significant shift towards the antiinflammatory cd14bright population. no significant differences regarding hla-dr expression or cytokine release could be demonstrated. conclusion this study shows that the suppression of the stimulated immune response after cpb can be alleviated by iv administration of mannitol or hemofiltration. in the light of data showing that this depression of the immune response might affect the postoperative course of patients, these results could lead to an improvement of the management of patients undergoing cardiac surgery with cpb.

Eligibility criteria:
inclusion criteria: * male patients * aged 35-80 * elective cabg surgery exclusion criteria: * previous cardiac surgery * ejection fraction \< 40% * valvular heart disease * myocardial infarction during the last 3 months * evidence of concomitant malignant or immunologic diseases * antecedent medication with corticosteroids or methylxanthines * hemoglobin \< 12 g/dl * body mass index \> 30

Keywords: immunedefense suppression cardiopulmonary bypass mannitol hemofiltration cytokines receptors, surface cd14
dexamethasone phonophoresis versus laser acupuncture on chronic rhinosinusitis

Conditions: Chronic Rhinosinusitis (CRS)

Summary: this study is designed to provide a comprehensive overview of evidence concerning the efficacy and safety of dexamethasone phonophoresis and laser acupuncture for treatment of chronic rhinosinusitis.


Eligibility criteria:
inclusion criteria: * age range between 30 to 50 years. * male and female patients will participate in the study. * all patients have chronic rhinosinusitis, who are experiencing 12 weeks or longer of 2 or more of the following signs and symptoms: mucopurulent drainage (anterior, posterior, or both) nasal obstruction (congestion) facial pain-pressure-fullness, or decreased sense of smell • all patients enrolled in the study will have their informed consent. exclusion criteria: * patients with metal implants (pacemakers, dental implants, or any other implants). * patients with cancer, pregnancy or impaired vascular circulation. * patients who suffer from mental or psychological disorders. * patients with any systemic diseases that may interfere with the objectives of the study. * patients with long-term use of corticosteroids or immunosuppressive agents. * congenital defects on face and nose. * fracture of nose or face. * patients who are contraindicated for corticosteroids use in patient who will receive dexamethasone phonophoresis. * allergic patients. * pervious nasal surgery. * patients with nasal septum deviation. * patients who had used antihistamines within 1 week, topical corticosteroids within2 weeks, systemic corticosteroids within 4 weeks, anti-cholinergic drugs within 3 days, antileukotriene drugs within 1 week, decongestants within 3 days, tricyclic antidepressants or phenothiazines within 2 weeks, non-steroidal analgesics within 2 weeks or any medication that may interfere with the objectives of the study.

Keywords: dexamethasone phonophoresis, laser acupuncture, chronic rhinosinusitis
study of the glycocalyx in abdominal aortic aneurysm

Conditions: Abdominal Aortic Aneurism; Surgery; Ischemic Reperfusion Injury

Summary: the investigators want to measure the degradation of the endothelial glycocalyx before and after clamping the aorta, in patients operated for a abdominal aortic aneurism.

50 patients is scheduled for enrollment. blood samples will be up taken before surgery, 10 min after reperfusion, at the end of surgery and the following morning. in addition the investigators are placing a renal venous catheter where blood samples will be up taken as mentioned above for the analysis of endothelial markers together with markers for kidney damage. the first 10 patient will act as part of a pilot study, where only measurement of the endothelial and renal failure markers will be performed.

Eligibility criteria:
inclusion criteria: * above 18 years exclusion criteria: * prior engagement in scientific study within the last 30 days.

Keywords: abdominal aortic aneurism endothelia glycocalyx reperfusion plasma
fnirs, listening effort, and motivation

Conditions: Hearing Loss

Summary: the purpose of the current study is to measure oxygenation in the pfc using fnirs in a sample of older adults with hearing loss. participants will be instructed to listen to sentences in noise at a challenging signal-to-noise-ratio, and to indicate what they heard using a closed-set response interface. participants will complete 4 sessions: a training session, and a session for each condition. during each test session, participants will be instructed to listen to at least 100 sentences. oxygenation, response times, and listening accuracy will be measured throughout.


Eligibility criteria:
inclusion criteria: * adults (18-99) years * binaural, symmetrical, sensorineural n2 (mild) to n5 (moderate-severe) hearing loss * experienced hearing aid users * fluent in english exclusion criteria: * minors (17 years or less) * hearing status that did not fall within inclusion criteria * vulnerable populations
identification of serum level of glutathione peroxidase 4

Conditions: Spondyloarthropathy

Summary: * analysis of the level of glutathione peroxidase 4 (gpx4) in ankylosing spondylitis and axial psoriatic arthritis patients. * the association of glutathione peroxidase 4 (gpx4) with disease activity and severity in ankylosing spondylitis and axial psoriatic arthritis patients.

ferroptosis, first reported by dixon et al. in 2012, is a form of non-apoptotic cell death driven by iron-dependent lipid reactive oxygen species (ros) and accelerated by the accumulation of lipid peroxides, ultimately leading to oxidative damage to phospholipid membranes and cell death . ferroptosis could be induced by iron metabolism disorder, lipid peroxidation accumulation, deficiency of glutathione (gsh) and inactivation of the antioxidant enzyme glutathione peroxidase 4 (gpx4). the morphological features of ferroptotic cells manifest as an aberrant mitochondrial ultrastructure, including a reduction in mitochondrial volume, an increase in mitochondrial membrane density, and the disappearance of mitochondrial cristae in ferroptotic cells . recent studies have increasingly reported on complex associations between ferroptosis and the immune system . the regulatory activity of ferroptosis in immune function and inflammation is multifaceted and involves innate, acquired, and autoimmunity. accumulating evidence in recent times has shown an association of ferroptosis with the pathogenesis and development of autoimmune diseases . spondyloarthropathy comprises a group of chronic inflammatory rheumatic diseases, including ankylosing spondylitis, reactive arthritis (reiter syndrome), arthritis or spondylitis associated with inflammatory bowel disease, and psoriatic arthritis, as well as undifferentiated spondyloarthritis. these afflictions predominantly affect the axial skeleton, causing pain and stiffness. currently, research on ferroptosis is still in its early stages; therefore, exploring the pathogenesis of ferroptosis and its role in various diseases, and proposing effective and targeted treatment methods have significant theoretical significance and practical value.

Eligibility criteria:
inclusion criteria: * patients diagnosed as ankylosing spondylitis according to asas criteria . \[13\] * patients diagnosed as psoriatic arthritis according to caspar criteria. \[14\] * age (\>18). exclusion criteria: * patient with other autoimmune rheumatic diseases. * patients with any of the following conditions: i) severe liver and kidney dysfunction; ii) hematopoietic diseases; iii) infectious diseases; iv) tumors; or v) other wasting diseases. \[15\] * patients received certain drugs (for example, sulfasalazine, artemisinin, statins), and experimental reagents (such as erastin) .\[16\]
prospective, randomised study: metabolic and functional effects of bariatric surgery accessed using pet and mri.

Conditions: Morbid Obesity

Summary: the objectives of this study are to measure effect of obesity on brain structure and molecular pathways, food-stimuli mediated brain activation response, on hormones affecting both feeding and energy balance as well as on bone metabolism and bone marrow fat. in the first phase the studies are performed at baseline before bariatric surgery and in the second phase post-operatively after 6 months. regional free fatty acid uptake are studied with pet and 14(r, s)-\[18f\]-fluoro-6-thia-heptadecanoic acid (\[18f\]ftha). changes in body fat distribution are investigated with magnetic resonance imaging (mri) brain reward system response to food stimuli is assessed using functional mri (fmri) and white and grey matter volumes using diffusion tensor imaging (dti). brain neurotransmitter system will be measured with \[11c\]raclopride and \[11c\]carfentanil and pet. in the second part of the study the same variables are studied after bariatric surgery: either laparoscopic sleeve gastrectomy or roux-en-y gastric bypass.

regional free fatty acid uptake in myocardium, skeletal muscle, subcutaneous fat, visceral fat, pancreas, liver, brain, intestine and the bone are studied with pet and 14(r, s)-\[18f\]-fluoro-6-thia-heptadecanoic acid (\[18f\]ftha). changes in body fat distribution are investigated with magnetic resonance imaging (mri) and magnetic resonance spectroscopy (mrs). brain reward system response to food stimuli is assessed using functional mri (fmri) and white and grey matter volumes using diffusion tensor imaging (dti). the study consists totally of 60 study subjects. of these 40 are morbidly obese adults, bmi

Eligibility criteria:
inclusion criteria: * 1) bmi \> 40 kg/m2 or
effectiveness of children experiencing nitrous oxide/oxygen inhalation sedation at an assessment visit before having treatment.

Conditions: Dental Anxiety

Summary: the purpose of this study is to find out the effect of experience of dental sedation at assessment on children's anxiety before the actual treatment session.

title: effectiveness of children experiencing nitrous oxide/oxygen inhalation sedation at an assessment visit before having treatment. background: dental anxiety is a common problem, affecting people of all ages, but predominantly children and adolescents. inhalation sedation (ihs) using nitrous oxide/oxygen (n2o/o2) mixture is a pharmacological behaviour management technique that is widely used to manage dental anxiety in children. it is suggested that the use of an acclimatisation would increase the acceptability and the efficacy of n2o/o2 success. even though the introductory appointment has been widely proposed, there have not been any studies conducted to measure the effectiveness of this appointment in improving the success of n2o/o2 sedation in children. aims: this study aimed to investigate the effect of experience of nitrous oxide/oxygen sedation at assessment prior to dental inhalation sedation on children's anxiety. methods: the study was a parallel randomised non blinded control clinical trial. children aged five to fifteen years who were seen at the leeds dental institute for dental treatment under inhalation sedation were recruited on the assessment appointment (1st visit). both two groups received an assessment appointment, however participants of the study group tried on the mask and the nitrous oxide/oxygen sedation while the ones of the control group tried on the mask without the nitrous oxide/oxygen sedation. following the assessment appointment, both groups received a second appointment for treatment. dental anxiety was measured through two different methods. primarily through the mcdasf questionnaire, which was completed once at the beginning of the assessment visit and twice at the beginning and end of the treatment visit. secondarily anxiety was measured though the e4 wristband which participants of both groups wore throughout both appointments and recorded their heart rate (hr) and skin temperature (st). at the end of the treatment visit, participants and their parents/legal guardians were asked to complete a feedback questionnaire related to the e4 wristband and the experience of n2o/o2 sedation at the assessment visit. - 6 -

Eligibility criteria:
inclusion criteria: patients attending the sedation unit for dental treatment under inhalation sedation. * children aged 5 to 15 years. * asa class i or ii. * first time having inhalation sedation. exclusion criteria: * participants who refuse to wear the mask. * language barriers where no interpreter was available * parents/carer who refused to sign consent or children who did not assent.