Kornimate/medical-research-clean huggingface dataset:
rule of carbone monoxyde in the ex vivo lung perfusion reconditionning

Conditions: Neurogenic Lung Edema

Summary: ex vivo lung perfusion (evlp) is not a new concept and has been widely used to study lung function in small animals. it also has been shown to be a useful technique to evaluate lungs from donation after cardiac death (dcd) (yeung, thorac surg clin, 2009). it has been recently demonstrated successful application of an acellular evlp technique in optimalizing lung function ex vivo for an extended period of time. following 12 h of normothermic evlp, patients were transplanted and demonstrated immediate life-sustaining function with promising short-term evolution (aigner, am j transplant, 2012; sanchez, j heart lung transplant, 2012; cypel, n engl j med, 2011). lung donation obtained after carbon monoxide intoxication has been recognized as excellent organs because of less general inflammation and less primary graft dysfunction after procedure. in a murine model of brain dead, carbon monoxide inhalation at a low concentration (50 to 500 parts per million (ppm)) exerts significant cytoprotection in several lung injury models via its vasodilatation, anti-inflammatory, and anti-apoptotic properties (dong, j heart lung transplant, 2010). the carbon monoxide inhalation down-regulates pro-inflammatory cytokines (tnf-alpha, il-6) along with the increase of anti-inflammatory cytokine (il-10) in recipient serum. the inhalation significantly decreases cell apoptosis in lung grafts, inhibiting mrna and protein expression of intercellular adhesion molecule-1 (icam-1) and caspase-3 in lung grafts (zhou, chin med j, 2008). apoptotis and inflammatory processes may, in part, concern alveolar tissue. research in the field of biomarkers is now opening new perspectives with the development of non-invasive tests allowing for monitoring inflammation and damage in the deep lung. blood tests (bernard, toxicol appl pharmacol, 2005) measuring lung-specific proteins (pneumoproteins) such as clara cell protein (cc16) and surfactant-associated proteins (a, b or d) are now available to evaluate the permeability and/or the cellular integrity of the pulmonary epithelium. these dosages may constitute an interesting way for monitoring the quality of the lung before implantation.


Eligibility criteria:
inclusion criteria: lung edema exclusion criteria: infection severe emphysema tumor
effects of acute pain vs context change on motor learning retention in young adults

Conditions: Pain, Acute; Motor Activity

Summary: to date, the effects of pain on motor learning have not been thoroughly investigated. when examining potential effects on retention of motor learning, it is important to dissociate any effects of pain from effects of a context change. the purpose of this research is to determine whether any altered retention of motor learning associated with acute pain is a true affect of pain or an affect of context (or both).


Eligibility criteria:
abbreviations: hr= heart rate, bpm= beats per minute; bp= blood pressure; add= attention deficit disorder; adhd= attention deficit hyperactivity disorder; moca= montreal cognitive assessment; gad-7= generalized anxiety disorder 7 scale; phq-2, phq-9= patient health questionnaire-2 and -9. inclusion criteria: * 18-35 years old * self-identifying as generally medically healthy * able to read, write and speak english * able to provide informed consent * willing to undergo the experimental pain or non-painful electrical stimulation, if selected exclusion criteria: * resting hr \ 100 bpm * resting bp \ 140/95 mmhg * any history or current mental health condition, learning/developmental disability or cognitive impairment, including add/adhd, severe anxiety, severe depression, autism spectrum disorder, insomnia, mild cognitive impairment, etc. * score on the moca \<23 * score on the gad-7 ≥ 10 * score on the phq-2 ≥ 2 and score on the phq-9 ≥ 10 * any current (within last 3 month) or chronic medical conditions, including any musculoskeletal, cardiovascular, endocrine, pulmonary, metabolic, psychiatric or neurological diagnosis * any implanted electronic medical devices (i.e., cardiac pacemakers, cardiac defibrillators, spinal cord neurostimulators) * any impaired sensation or weakness in either lower extremity or in the area targeted for the stimulus * history of serious concussion or head injury, defined as a loss of consciousness for \> 5 minutes and/or requiring medical treatment, or \> 2 concussions over the lifespan * any history of acute or chronic problems with balance, any dizziness, or \> 1 fall in the last 12 months * taking 4 or more medications * currently or regularly using any analgesic medications, over-the-counter remedies, or any other treatment for the purposes of pain relief (i.e., baby aspirin for heart health permitted, etc.) * any current or chronic pain condition during the last year, located anywhere in the body * allergy to capsaicin or hot peppers * any skin lesion, breakage or irritation in the area targeted for the painful stimulus * skin sensitivity to soaps/creams/perfumes or to heat * poor circulation in the area targeted for the painful stimulus * prior participation in a locomotor learning study in this lab within the last 2 years

Keywords: acute pain young adults pain motor learning motor consolidation gait locomotion walking generalization
anterior cruciate ligament study

Conditions: ACL Injury; ACL; Anterior Cruciate Ligament Rupture

Summary: this retrospective, prospective observational study aims to evaluate the epidemiology and rate of anterior cruciate ligament re- rupture after surgery in patients treated from january 2020 to december 2030 by recording both clinically and radiographically ligament reconstruction. the primary outcome is the rate of rupture of the anterior cruciate ligament as measured by the lachmann test in which a positive value for re-rupture is an anterior translation of the tibia greater than 10mm relative to the femur secondary objectives: verify predisposing factors to anterior cruciate ligament injuries (so anatomical factors such as tibial slope, trochlear groove), demographic factors (age, sex, weight, sports played), and the rate of return to sports, quality of life via questionnaires, and arthrosis at the operated knee


Eligibility criteria:
inclusion criteria: * - males and females- attained skeletal maturity * 18-65 inclusive * patients operated on anterior cruciate ligament reconstruction surgery at the hospital's casco unit from 2010 to 2030 * signature informed consent for patients who will be operated on in the prospective phase (from ce approval date to 2030) exclusion criteria: * failure to reach skeletal maturity * concomitant ligamentous injuries (pcl, mcl, lcl) * neuropsychiatric illness, developmental disorders * pregnant women through self-declaration or breastfeeding * minors
comparison of single versus repeat doses of am-101 in the treatment of acute inner ear tinnitus

Conditions: Tinnitus

Summary: the purpose of the study is to evaluate the therapeutic benefit and safety of intratympanic am-101 injections in comparison to placebo in the treatment of persistent acute inner ear tinnitus.


Eligibility criteria:
inclusion criteria: * tinnitus following acute acoustic trauma, acute otitis media, middle ear surgery or inner ear barotrauma; with onset less than three months ago. exclusion criteria: * tinnitus that is not completely maskable * fluctuating tinnitus * intermittent tinnitus * meniere's disease * ongoing acute or chronic otitis media or otitis externa.
combination of lymphatico-venular anastomosis and liposuction to treat cancer-related lymphedema

Conditions: Description of an Effective Surgical Strategy to Treat Cancer-related Lymphedema; Combination of LVA and Liposuction Guarantees Long Lasting Results

Summary: * cooperation of an international team with many years of experience in surgical management of lymphedema * description of an effective surgical strategy to treat cancer-related lymphedema, a high incidence pathology * the combination of lva and liposuction guarantees long lasting results

cancer-related lymphedema represents one of the major complications of cancer treatment, especially for breast and gynecologic cancers. moreover, it has high impact on cancer survivors and healthcare systems. lymphedema management still remains challenging. the better understanding of lymphedema physiopathology as well as the development of sophisticated surgical and diagnostic techniques have led to effective strategies to address lymphedema patients but, despite the considerable interest in international literature, no consensus exist. the combination of lva and liposuction may represent an effective strategy in treating patients with cancer-related lymphedema, in order to reach a significant decrease in volume and reduction of lymphangitis rate as well as stable results in time. in addition, it has the aim of being minimally invasive and well tolerated by patients

Eligibility criteria:
inclusion criteria: patients affected by secondary lymphedema * free from cancer disease exclusion criteria: - persistence of the neoplastic pathology - patients affected by primary lymphedema
tobacco cessation for veterans with post traumatic stress disorder (ptsd)

Conditions: Tobacco Use Cessation; Post Traumatic Stress Disorders

Summary: the goal of this study is to improve the effectiveness of tobacco cessation treatment for veterans with post traumatic stress disorder (ptsd) through ongoing, integrated care management approach using telehealth and motivational interviewing counseling. both tobacco dependence and ptsd represent enormous challenges to the veterans affairs (va) healthcare system.

background: veterans smoke at a higher rate (30%) than the u.s. adult population (21%), and veterans with ptsd have even higher rates of smoking (53-66%). evidence has shown that any tobacco dependence treatment strategy must be integrated in the health care system because consistent and effective delivery of tobacco cessation requires coordinated interventions. persistent tobacco users typically cycle through multiple periods of relapse and remission. veterans with ptsd (279,256 in 2005) who are treated for smoking cessation may need more comprehensive aid to be successful. failure to appreciate the chronic nature of tobacco dependence may impede comprehensive and consistent treatment. care management using telehealth has been shown to improve access to care while reducing costs for veterans with chronic diseases and has the potential to coordinate smoking cessation with care for other chronic diseases. nurses have successfully managed chronic diseases using telehealth by focusing on increasing self-management, positive behaviors and knowledge. nurses are vital to increasing the level of support in the community through education and motivation and by responding to medical events in order to improve veterans' health. objectives: the study is designed to determine if adding motivational counseling and care management using the ptsd health buddy to usual care improves smoking quit rates of veterans with ptsd. specific aims are to compare: 1) self-reported quit attempts, progression through the stages of change, and quit rates, 2) patient perception of care coordination, and 3) changes in ptsd symptoms in veteran smokers with ptsd who receive a nurse-driven telephonic motivational counseling intervention triggered by responses to stage-based smoking cessation questions in addition to usual care to those who receive usual care only.

Eligibility criteria:
inclusion criteria: * diagnostic and statistical manual of mental disorders iv criteria (dsm-iv) for diagnosis code 309.81 ptsd * willingness to participate * currently smoking 1 or more cigarettes per day exclusion criteria: * use smokeless tobacco, pipes or cigars instead of cigarettes * have imminent risk of suicide or violence * have severe psychiatric symptoms or psychosocial instability likely to prevent participation in protocol (provider will assess appropriateness) * have clinically apparent gross cognitive impairment * unable to connect health buddy in home

Keywords: nursing care veterans
clinical performance of resin-modified glass ionomer and composite restorations in permanent teeth

Conditions: Dental Caries in Children

Summary: the aim of this randomised controlled double-blinded, split mouth, single-center clinical trial was to evaluate the 18-month clinical performance of nano-filled resin-modified glass ionomer and sub-micron hybrid resin composite restorations in lower first permanent teeth of pediatric patients.

occlusal carious lesions on the left and right mandibular first molar teeth of 96 pediatric patients (54 female, 42 male) were restored in a split-mouth study design. nano-filled resin-modified glass ionomer (nano-rmgic) (ketac n 100, 3m/espe, usa) was used to restore the carious lesions for patients in the treatment group while a sub-micron hybrid resin composite (spectrumtph3, dentsply, usa) was used for patients in the control group. clinical evaluation of restorations were performed at the 1st week, 6th, 12th and 18th month recalls by two calibrated examiners according to the modified-usphs criteria.

Eligibility criteria:
inclusion criteria: 1. patients with two comparable occlusal carious lesions on both mandibular first permanent molars. 2. neutral occlusion with a natural antagonist tooth 3. patients that are able to come to recalls 4. patients with a good oral hygiene exclusion criteria: 1. patients suffering systemic diseases or allergies 2. patients with gastrointestinal problems 3. mandibular first molar teeth with restorations 4. patients with oral habits 5. patients receiving orthodontic treatment 6. hypomineralized or hypoplastic first molars

Keywords: nano-filled resin-modified glass ionomer sub-micron hybrid resin composite permanent molar teeth
clotrimazole enemas for pouchitis in children and adults

Conditions: Ulcerative Colitis; Pouchitis; Ileitis; Inflammatory Bowel Disease

Summary: colectomy with creation of an ileal pouch (ipaa) is now the treatment of choice for patients with ulcerative colitis that is resistant to existing medical therapies. the development of inflammation in these ileal reservoirs, a clinical entity referred to as pouchitis, is the most common long-term complication of this procedure and can affect 50-60% of adults and children. we have previously demonstrated that clotrimazole (delivered as a rectal suppository) is generally safe, effective, and displays poor systemic absorption when used in pediatric and adults with active pouchitis. we saw clinical benefit in patients with pouch disease that had previously failed to respond to standard antibiotic, steroid, or immunosuppressive therapies. the clinical trial outlined here will define the effectiveness and safety of topical clotrimazole therapy (delivered as a rectal enema) in pediatric (aged greater than two years) and adult patients with pouchitis. subjects in this study will be randomly assigned to receive either placebo (no active drug, 4 subjects) or one of two clotrimazole therapy groups: 2500 mg/day (8 subjects) or 4000mg/day (8 subjects). no washout period is required, and subjects will be allowed to continue their existing anti-inflammatory medications during their participation in the study. clotrimazole will be delivered nightly in the form of an enema. subjects will undergo flexible sigmoidoscopy (pouchoscopy) prior to and again after completing one month of study therapy, and pouch disease activity will be graded at after each procedure using the pouchitis disease activity index (pdai). clinical improvement will be defined as a drop in pdai score. if the drop in pdai scores between placebo and either active clotrimazole treatment group is not significant, and no subject experiences what are determined to be study-related adverse effects, a second cohort of subjects will be recruited and studied after receiving one month of either placebo (4 subjects), 6000 mg/day clotrimazole (8 subjects), or 7500mg/day clotrimazole (8 subjects). subjects will be assessed for adverse effects at the midpoint of the study. clotrimazole blood levels will be measured during the first and last day of study participation. in addition, adults will complete a health related quality of life assessment at baseline and after completing study drug therapy. all subjects will be eligible for one month of open-label study drug therapy after completing one month of study drug therapy.


Eligibility criteria:
* age greater than 2 years * availability of parent or legal guardian (for those less than 2 years of age). * history of ulcerative colitis treated with colectomy and ileal pouch * diagnosis of acute or chronic pouchitis

Keywords: pouchitis colitis ileitis
a study of efficacy and safety of qutenza in patients with post-operative peripheral neuropathic pain

Conditions: Post-operative Peripheral Neuropathic Pain

Summary: the aim of this study is to monitor the effectiveness and used dosage of the 8% capsaicin patch in real-life clinical practice in the treatment of post-operative neuropathic pain.


Eligibility criteria:
inclusion criteria: * diagnosed peripheral post-operative neuropathic pain exclusion criteria: * hypersensitivity to capsaicin * pregnancy * diabetes mellitus * treatment of face

Keywords: qutenza 8% capsaicin patch non-interventional post-operative peripheral neuropathic pain observational czech republic
representations of transplantation in patients and in health care professionals

Conditions: Cystic Fibrosis

Summary: main objective : this project aims to have a better understanding of the influence of representations of patients with mucoviscidosis, their assistants and their medical persons in the choice of patients to accept or not lung transplantation. specific objectives : 1. identify the knowledge, representations, or feelings of patients which could constitute bridles or factors of motivation to use for transplantation. 2. identify the knowledge, representations, or feelings of medical persons which could constitute bridles or factors of motivation to the "encouraging" proposal to patients of lung transplant. 3. identify the knowledge, representations, or feelings of assistants which could constitute bridles or factors of motivation to the "encouragement" of lung transplantation at its close. 4. identify the needs of patients, assistants and medical persons to successfully reduce these bridles to transplantation and increase the factors of motivation. 5. compare the representations of patients, assistants and medical persons 6. search representations associated with patients who refuse the transplantation and those who accept the transplantation


Eligibility criteria:
inclusion criteria: * for patients : * adult patient (those concerned by the suggestion of lung transplant). * at the time of transplant indication : after the first suggestion of the medical person, before or after the preoperative graft check-up but before registration on waiting list. * for medical persons : * medical persons involved in the suggestion of lung transplantation to the patients. * for assistants : * adult close to the patient and that the patient sees as a resource person and advisor in his choices for the transplant : reference person having a major influence for the patient (spouse, parent, sibling, friend ...) exclusion criteria: * for patients : * patient with a psychiatric disorder * patient in intensive care unit * palliative care patient * patient aged under 18 years old * patient refusal * for medical persons : * medical person refusal * for assistants : * assistant or patient refusal

Keywords: lung transplantations representations mucoviscidosis
comparison of postoperative analgesic consumption of the erector spina plane block and serratus anterior plane block

Conditions: Thoracic Diseases

Summary: to evaluate the ability of erector spina plane block and serratus anterior plane block to decrease postoperative pain and analgesia requirements in patients undergoing thoracotomy.

thoracic wall nerve blocks such as erector spina plane block and serratus anterior plane block have become popular for preoperative pain control in patients undergoing thoracotomy.

Eligibility criteria:
inclusion criteria: asa i- asa ii patients exclusion criteria: * history of allergy to the study medication * refusal to participate

Keywords: dispne, pain
impact of moderate exercise training on vitals and peak vo2 in different age categories of adult in covid-19.

Conditions: Covid19

Summary: * to determine the impact of moderate exercise training on vitals (bp, hr) in different age categories of adult in covid-19. * to determine the impact of moderate exercise training on peak vo2 in different age categories of adult in covid-19 * to determine muscle discomfort due to physical training.

as of 30th january 2020, the outbreak of the novel coronavirus disease, later called covid-19, was declared a public health emergency. governments' immediate protective measurements aim to slow down the ongoing spread of the covid-19 disease. coronavirus had infected people exponentially. it has a typical symptom of influenza which includes fever, cough, fatigue sore throat and additional symptoms like breathlessness and diarrhea. there was no specific treatment to cure it and no vaccination to prevent it from further progression. the solitary solution for prevent of this virus was isolation and no gathering, which has caused people to sit in their houses and wash hands. literature shows that a significant larger reduction in blood pressure was observed in participant performing aerobic exercise. a study shows comparison between african and asian population with hypertension indicates that asian participant reduced more bp as compared to african .

Eligibility criteria:
inclusion criteria: * cognitively intact * age categories (young adult 17 -30, middle age adults 31 to 45, old age above 45) * sbp\>120 mm hg or dbp\>80 mm hg, and who had no physical limitations that precluded exercise participation were recruited from the general population from pakistan in covid era. * no regular exercise since march 2020 (start of covid era) 3 months at least. exclusion criteria: * participant failing to fall in this category would be excluded of the study. * uncontrolled hypertension * major joint impairment * bone fracture in the last 6 months * asthmatic patients