Kornimate/medical-research-clean huggingface dataset:
physiologic comparison between niv-nava and ps in preterm infants

Conditions: Noninvasive Neurally Adjusted Ventilatory Assist and Pressure Support in Preterm Infants

Summary: neurally adjusted ventilatory assist (nava) has been shown to improve patient- ventilator interaction and reduce asynchronies. this is a short-term physiologic comparison between psv (pressure support ventilation) and nava in delivering noninvasive ventilation through a nasal cannula, in premature infants postextubation. patients will undergo a 30-min crossover trial of noninvasive psv and nava, 15 minutes each. diaphragm electrical activity (eadi)and airway pressure (paw) are recorded to derive neural and mechanical respiratory rate and timing, inspiratory trigger delays time of synchrony between diaphragm contraction and ventilator assistance, and the asynchrony index (ai).


Eligibility criteria:
inclusion criteria: * preterm infants less than 32 weeks of gestational age * intubated more than 48 hours after birth * subjected to extubation with minimal ventilator setting (mean airway pressure \< 7cmh2o + peak inspiratory pressure \< 13 cmh2o + fio2 \< 0.4 + respiratory rate \< 35/min) * with informed consent from parents exclusion criteria: * with major congenital anomalies * use of sedative or anesthetic drugs * hemodynamic instability * grade 3 or higher intraventricular hemorrhage * phrenic nerve palsy

Keywords: preterm infant less than 32 weeks of gestation age intubated more than 48 hours after birth postextubation
evaluation of the effectiveness of narrative nursing

Conditions: Alzheimer Disease; Narrative; Depression, Anxiety

Summary: to explore the effects of narrative nursing on mental state, life ability and emotion of patients with alzheimer's disease (ad).

there is no effective clinical treatment, mainly through taking western drugs to control the alzheimer's disease, but the treatment cycle is long, the cost of drugs is high, and the patient's family nee care, resulds long-termting in a huge economic and psychological burden on the patient and family recipients. narrative nursing is an intervention mode of psychological nursing.in practice, narrative nursing can guide patients to actively organize experiences into various events with certain practical significance, attach importance to personal feelings and experiences, promote the psychological growth of patients and promote the generation of upward motivation.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of alzheimer's disease. 2. forgetting is the main cognitive impairment;. 3. the patient has basic language communication ability. 4. patients were treated with the same regimen. exclusion criteria: 1. patients with other common neurological and mental disorders (depression, psychosis, vascular cognitive impairment). 2. patients with heart, liver and other vital organ dysfunction. 3. patients with severe cardiovascular disease. 4. patients with severe physical disorders.
effect of lipikar urea 30% before actinic keratoses treatment

Conditions: Actinic Keratoses

Summary: this study is conducted in one center in germany, in adult subjects having actinic keratoses (grade i or ii) lesions on the scalp and meeting specific inclusion/exclusion criteria. the purpose of the study is to evaluate a holistic management (efficacy, tolerability and lesion cosmetic outcomes) of tolak® treatment.

actinic keratoses (ak) are chronic skin changes usually induced by uv radiation. there are numerous options to treat ak. some of the most used field-directed therapies include topical therapy with 5-fluorouracil (5-fu) cream and photodynamic therapy. however, the treatment with 5-fu is not without side effects (erythema, pruritus, itching/burning, etc.). therefore, in daily clinical practice, cosmetic pre- and concomitant applications of cosmetics are often recommended to increase the efficacy as well as the tolerability of tolak®. the aim of this randomized, evaluator blinded, controlled parallel group study conducted in compliance with the 2013 version of the declaration of helsinki is to determine whether and how the application of cosmetics leads to an influence on the microbiome of ak. statistical method: the variables will be analyzed by using the cochran-mantel-haenszel (cmh) statistic, after ridit transformation with the row mean difference statistics, testing the hypothesis of equality. each test will be two-sided, at the 0.050 significance level.

Eligibility criteria:
inclusion criteria: * diagnosis of at least 4 non-hypertrophic, non-hyperkeratotic actinic keratosis of the the scalp * planned treatment of actinic keratoses of the scalp with tolak® * olsen grade i or ii exclusion criteria: * known or documented intolerance to any of the ingredients of tolak® or lipikar urea 30% * treatment of actinic keratoses in the treatment area within the past 3 months (e.g. photodynamic therapy, topical 5-fu, diclofenac, imiquimod, cryotherapy etc.) * suspected invasive squamous cell cancer in the treatment area * chronic wounds, erosions, pre-existing inflamed or infected skin with disruption of the epidermal barrier in the treatment area current or within the last 8 weeks given systemic cancer medication or systemic treatment with 5-fluorouracil

Keywords: actinic keratoses lipikar urea 30% olsen grade
seek, test, treat strategies for vietnamese drug users: a randomized controlled trial

Conditions: HIV; Addiction

Summary: this research examines the effectiveness of an intervention that employs seek, test, and treat strategies for vietnamese injection drug users (idu) and their network members, by ensuring that high risk individuals are sought for hiv testing and promptly referred to and maintained on antiretroviral therapy (art). hiv prevention interventions are provided to idus who test hiv-negative, as well as those who test hiv-positive. hiv-positive idus will be referred to hiv care through a two-arm randomized controlled trial to compare the effects of different levels of engagement in care on art uptake, art adherence, and treatment outcome.

opioid injection and hiv infection are major public health problems in vietnam. injection drug users (idus) have a high burden of hiv infection (20% hiv prevalence, nationally; 6% mortality per year) and the high rate of hiv transmission continues (hiv incidence, 5% per year). the investigators propose an intervention that employs the seek, test, and treat strategies for the idu population and their network members, by ensuring that high risk individuals are sought for hiv testing, promptly referred to and maintained on art, while hiv prevention interventions provided to the many who test hiv-negative, as well as those who test hiv-positive. the intervention will seek and test idus and their network members in the community, particularly those who are recently released from drug treatment centers. hiv-positive idus will be referred to hiv care through a two arm randomized controlled trial to compare the effects of different levels of engagement in care on art uptake, antiretroviral adherence, and treatment outcome.

Eligibility criteria:
inclusion criteria: 1. age 18 years or older; 2. recently released from drug treatment centers; 3. positive hiv serology; 4. male; 5. meet criteria for art initiation according to vietnam's national guidelines; 6. provide informed consent for the study; and 7. reside in study area and do not plan to move away in the next 18 months. exclusion criteria: 1. currently on art; 2. co-enrollment in other hiv interventional research study; 3. unwilling to provide locator information.
effective training in overweight and obese people

Conditions: Obesity; Overweight

Summary: the aim is to come to a consensus about how to prescribe exercise training that actually helps overweight and obese people. thus, the present study determines the effects of several types of exercise training to define the one with the largest effect with the least effort.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) over 30 exclusion criteria: * not able to walk on a treadmill * participating in an other study * serious cardiovascular diseases

Keywords: aerobic capacity endothelial function exercise
expression of mirna-138 and cyclin d1 in oral mucosa of patients with oral lichen planus

Conditions: Oral Lichen Planus

Summary: 60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. expression of mirna-138 and cyclin d1 were evaluated in oral mucosa utilizing quantitative real-time polymerase chain reaction and immunohistochemistry.

60 individuals were subdivided into 3 groups, into 2 groups, 30 patients with oral lichen planus, 30 control individuals having age, gender and periodontal status matched with both patients groups acting as a control group. relative gene expression of mirna-138 was estimated using quantitative real-time polymerase chain reaction technique in oral mucosa of both oral lichen planus patients and control subjects. sub grouping of oral lichen planus patients were performed into reticular, atrophic and erosive groups (n=10 each). cyclin d1 gene expression was estimated using quantitative real-time polymerase chain reaction technique and cyclin d1 protein level was estimated using immunohistochemistry.

Eligibility criteria:
inclusion criteria: * patients with oral lichen planus. exclusion criteria: * any systemic disease other than oral lichen planus. * smokers. * pregnant females. * periodontal diseases.
the effect of the use of bathe interview technique on treatment compliance in hypertension patients in primary care

Conditions: Essential Hypertension

Summary: the research is planned to evaluate the treatment compliance after the bathe interview technique in hypertension patients.

in order to be evaluated for suitability for the study, patients aged 18-80 who have been diagnosed with hypertension for at least 6 months (n= 220) were interviewed and 86 hypertension patients who met the inclusion criteria and volunteered for the study were included in the study. participants whose eligibility was determined as a result of the evaluation in terms of inclusion and exclusion criteria were asked about their volunteerism in the intervention study, their written consent was obtained from those who volunteered, and those who volunteered were randomized.

Eligibility criteria:
inclusion criteria: * being a patient of hypertension * be over 18 years old * be less than 80 years old * to have been diagnosed for at least 6 months * volunteering * to be able to use any of the online video calling channels exclusion criteria: * communication problem * presence of psychiatric illness and/or use of psychiatric medication * pregnancy
efficacy and safety study of total glucosides of paeony combined with acitretin to treat psoriasis

Conditions: Psoriasis

Summary: this is a randomized, double blind, placebo parallel-controlled, multi-center clinical trial. patients with psoriasis vulgaris were randomly divided into the experiment group （treated with tgp combined with acitretin capsules) and control group （treated with placebo combined with acitretin capsules）.the treatment lasted 12 weeks. the efficacy and safety were evaluated at the baseline, as well as 2, 4, 8 and 12 weeks after the beginning of treatment.the investigator's hypothesis tgp combined with acitretin capsulesin is more safe and effective than acitretin capsulesin to treat psoriasis vulgaris.


Eligibility criteria:
inclusion criteria:meet the following conditions 1. diagnosed according to classification criteria for psoriasis vulgaris; 2. patients aged 18 to 65 years (to the date of screening); 3. pasi grade\>7point\<20 point; 4. not treatment in the topical corticosteroids、immunosuppresso、biologicals agents or tretinoin cream、phototherapy nearly one months before enrolled. 5. understanding the whole process of the study, voluntary participation and signed the informed consent; 6. patient compliance is good, can guarantee in course of observation. exclusion criteria:one of the following is not included in this study: 1. pregnant women, ready to pregnant or lactating women; 2. known to root of herbaceous peony total glycosides (tgp) drug allergy; 3. have a serious heart, lung, kidney and other vital organs and endocrine system lesions and the history 4. patients is liver function abnormal persons (alt above the center laboratory normal limit) or hepatitis b patient grain carriers; 5. need insulin control of diabetes; high blood pressure did not get good controller ; 6. patients with white blood cells \<4.0 × 109 / l, or a definite anemia (hemoglobin less than 100g / l), or platelets \<100 × 109 / l, or other blood disease; 7. patients with chronic diarrhea, or peptic ulcer nearly 1 year; 8. patients suffering from malignant tumor; 9. patients suffering from acute and chronic infectious diseases; 10. mental disorders, history of alcohol abuse, drug or other substance abuse; 11. other cases which researchers believe that can not enroll.

Keywords: total glucosides of paeony(tgp) acitretin capsules psoriasis vulgaris
effect of photodynamic therapy with low-level laser on infected dentin in primary teeth: a controlled clinical trial

Conditions: Dental Caries

Summary: the aim of the proposed study is to assess the clinical effect of photodynamic therapy (pdt) on dentin with carious lesions in primary teeth. patients with primary molars exhibiting deep carious lesions on the occlusal surface indicated for restorative treatment will be randomly allocated to three groups: group 1 - traditional caries removal with a low-speed drill; group 2 - pdt + papamblue (carious tissue removal agent) modified with methylene blue; and group 3 - pdt with methylene blue 0.05%. pdt will be performed with low-level laser for the treatment of the carious tissue. dentin samples will be removed before and after pdt for microbiological analysis. the microbiological samples will be cultured in brucella blood agar, mitis salibarius-bacitracin agar and rogosa sl agar. the teeth will then be restored using high-viscosity glass ionomer cement, with clinical and radiographic follow up at six, 12 and 24 months. the data will be submitted to descriptive statistics.

the groups of study (group 1)- conventional caries removal with low-speed drill (group 2)- pdt combined with papamblue (group 3)- pdt combined with methylene blue the data in descriptive statistics will be used the chi-squared test and fisher's exact test will be used for the comparison of categorical variables (age and gender). the student's t-test and analysis of variance will be used for the comparison of signs and symptoms of reversible pulpitis. pearson's correlation coefficients will be calculated to determine the strength of correlations among the continuous variables.

Eligibility criteria:
inclusion criteria: adequate health, with no systemic conditions; cooperative behavior; presence of at least one primary molar with acute, active carious lesion not surpassing 2/3 of the dentin and only involving the occlusal face, with direct view and access and no clinical or radiographic signs of pulp involvement exclusion criteria: systemic condition; uncooperative behavior; class ii, iii, iv or v carious lesion (black's classification); clinical evidence of carious lesion involving enamel, deficient restorations, insufficient size of carious lesion on dentin for access to dental instrument, hidden carious lesions, sign or symptom of pulp involvement, clinical impossibility of restoration; radiographic evidence of pulp involvement; carious lesion surpassing 2/3 of dentin.

Keywords: dental caries pdt lllt pediatric dentistry
evaluation of a video-ludic re-education of the paretic upper limb in chronic hemipartic patients post cerebral vascular accident

Conditions: Stroke; Motor Activity

Summary: the aim of this randomized controlled study with stroke patients is to demonstrate that a re-education with interactive table with instrumented objects delivering sensory feedback and serious game improve certain motor functions of the paretic upper limb than rehabilitation based on a standardized self-rehabilitation program.


Eligibility criteria:
inclusion criteria: * stroke patients * subject with gripping ability: capable of peeling off the connected object from the table, presented in its grip area. exclusion criteria: * severe cognitive disorders preventing the completion of the task * bilateral brain lesions

Keywords: serious game stroke rehabilitation connected objects
evaluation of diabetes self-management consultant care

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to find out if self-management consultant (smc) intervention will be more effective than usual care in improving blood glucose control and diabetes-related quality of life for adults with type 2 diabetes.

this study is designed to compare the effectiveness of a diabetes self-management consultant (smc) intervention for adults with type 2 diabetes with unsatisfactory glucose control (i.e., hba1c ≥ 8%--the value chosen as "high risk" by the diabetes quality improvement project which is an initiative of the health care financing administration, the american diabetes association, and the foundation for accountability) to a control group selected using the same criteria. the smc intervention will be implemented and evaluated in two different health care systems serving two distinct populations of patients with diabetes. after signing the informed consent document, subjects will be randomized to the smc intervention or a control group. all subjects in the study will complete a baseline assessment of their diabetes care and health status. subjects randomized to the smc intervention will have an individual meeting with the smc to review and refine a self-management plan based on the subject's priorities and goals. these subjects will receive individual follow-up and support during the year, through monthly phone calls and an annual meeting with the smc and their primary care physician. subjects randomized to the control group will receive usual care following their baseline and their 12-, 24-, and 36-month assessments. unlike most nurse-manager studies, the smc's interactions with patient care will use a theory-based behavioral approach with which we have extensive experience. the study is designed to evaluate the effectiveness of the smc intervention compared to usual care. all records will be handled confidentially. lab results and personal data will be linked by a research specific identifier code.

Eligibility criteria:
inclusion criteria: * adults over age 21 diagnosed with type 2 diabetes for at least one year. exclusion criteria: * patients under psychiatric care * currently pregnant * those who have not been diagnosed with type 2 diabetes

Keywords: diabetes self management type 2 diabetes
paclitaxel in treating patients with refractory or recurrent endometrial cancer

Conditions: Endometrial Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. purpose: phase ii trial to study the effectiveness of paclitaxel in treating patients who have refractory or recurrent endometrial cancer.

objectives: * determine the therapeutic activity of paclitaxel in patients with refractory or recurrent endometrial papillary carcinoma. * determine the objective response and duration of response in patients treated with this regimen. * determine the acute side effects of this regimen in these patients. outline: this is a multicenter study. patients receive paclitaxel iv over 3 hours on day 1. treatment repeats every 3 weeks in the absence of disease progression or unacceptable toxicity. patients are followed every 12 weeks. projected accrual: approximately 16-29 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed endometrial papillary carcinoma (uterine papillary serous carcinoma) * progressive or recurrent * bidimensionally measurable disease * platinum refractory disease, defined by one of the following: * progression during platinum-based chemotherapy * stable disease for at least 4 courses of platinum-based chemotherapy * recurrence within 4 months of platinum-based chemotherapy * no brain involvement or leptomeningeal disease patient characteristics: age: * 75 and under performance status: * who 0-2 life expectancy: * not specified hematopoietic: * neutrophil count at least 1,500/mm3 * platelet count at least 100,000/mm3 hepatic: * bilirubin no greater than 50 umol/l renal: * bun no greater than 8.0 mmol/l * creatinine no greater than 120 umol/l * creatinine clearance at least 60 ml/min other: * not pregnant * fertile patients must use effective contraception * hiv negative * no other prior or concurrent malignancy except basal cell carcinoma of the skin * no active bacterial infection (e.g., urinary tract infection) * no uncontrolled or potentially active site of infection (e.g., fistula or abscess) * no psychological, familial, sociological, or geographical condition that would preclude study prior concurrent therapy: biologic therapy: * not specified chemotherapy: * see disease characteristics * at least 4 weeks since prior chemotherapy * at least 1 prior platinum containing regimen * at least 50 mg/m2 per course for a maximum of 28 days for cisplatin * at least 5 times auc for a maximum of 4 weeks per course for carboplatin * prior non-taxane-containing chemotherapy allowed endocrine therapy: * at least 4 weeks since prior hormonal therapy radiotherapy: * at least 4 weeks since prior radiotherapy * at least 3 months since prior radiotherapy to target lesion * concurrent radiotherapy allowed for bone pain provided evaluable lesions are outside of irradiation field) surgery: * prior surgical management of lymph nodes allowed

Keywords: recurrent endometrial carcinoma endometrial papillary serous carcinoma
anticoagulation one year after ablation of atrial fibrillation in patients with atrial fibrillation (alone af study)

Conditions: Atrial Fibrillation Patients With Moderate or High Stroke Risk Who Had Undergone Catheter Ablation of Atrial Fibrillation

Summary: there has no evidence for the anticoagulation in patients who had undergone catheter ablation of atrial fibrillation, and has maintained sinus rhythm for more than 1 year. however, anticoagulation can increase the risk of bleeding, the study evaluating the role of oral anticoagulation is needed in this patients. this study will compare the efficacy and safety of non-vitamin k anticoagulants (apixaban) and no oral anticoagulation in patient with sinus rhythm one year after catheter ablation of af.

this study is a prospective randomized study which was performed in multicenter (general hospital) in korea. inclusion criteria is atrial fibrillation patients with moderate or high stroke risk (cha2ds2-vasc\>=1 male, and \>=2 female) who had undergone catheter ablation of atrial fibrillation, and has maintained sinus rhythm for more than 1 year. anticoagulation (apixaban group) will take apixaban (5 mg bid or 2.5 mg bid according to dose guideline) for 2 years, and nonanticoagulation group will not take any oral anticoagulants for the same period. if the patients have the recurrence of af, they will take anticoagulation according to standard treatment, and will be censored. we will analyze and compare the efficacy and safety of non-vitamin k anticoagulants (apixaban) and no oral anticoagulation in these patients.

Eligibility criteria:
inclusion criteria: 1. no recurrence of atrial fibrillation one year after catheter ablation of atrial fibrillation 2. cha2ds2-vasc score \>=1 (male) or \>=2 (female) 3. age: 19 to 80 years 4. non-valvular atrial fibrillation 5. those who consent the study. 6. those who can be followed after enrollment exclusion criteria: 1. severe liver or kidney dysfunction 2. thyroid dysfunction 3. pregnant or breastfeeding women 4. malignant tumors that have not been completely cured 5. severe structural heart disease 6. predicted survival is less than 12 months 7. patients who do not understand the content of the study or disagree with it

Keywords: catheter ablation anticoagulation efficacy safety