Kornimate/medical-research-clean huggingface dataset:
hyperbaric oxygen for covid-19 patients

Conditions: COVID-19

Summary: hyperbaric oxygen therapy (hbot) treatment will be provided to patients as an adjunct to standard therapy for a cohort of 40 covid19-positive patients with respiratory distress at nyu winthrop hospital. all patients prior to the clinical application of hbot will be evaluated by the primary care team and hyperbaric physician. after the intervention portion of this study, a chart review will be performed to compare the outcomes of intervention patients versus patients who received standard of care.

this is a single center prospective pilot cohort study to evaluate the safety and efficacy of hyperbaric oxygen therapy (hbot) as an emergency investigational device for treating patients with a novel coronavirus, disease, covid-19. patients that meet inclusion criteria will be consented by the hyperbaric physician. they will then be transported from the ed or other unit to the hyperbaric unit maintaining airborne precautions based on the most current hospital protocol. all study personnel will have proper ppe at all times. the patient will then be placed into the monoplace chamber and when the chamber door is closed the patient will remove any respiratory filter/mask that was placed. the patient will receive 90 minutes of hyperbaric oxygen at 2.0 ata with or without airbreaks per the hyperbaric physician. upon completion of the treatment the patient will then return to the medical unit and continue all standard of care. additional treatments (up to 5) can be given if warranted and agreed upon by the patient and all members of the team caring for the patient. after the intervention portion of this study, a chart review will be performed to compare the outcomes of intervention patients versus patients who received standard of care.

Eligibility criteria:
inclusion criteria: in order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. male or female, age \> 18 years 2. positive covid 19 test 3. respiratory compromise defined by spo2 \<93% 4. ability to sign informed consent exclusion criteria: an individual who meets any of the following criteria will be excluded from participation in this study: 1. pregnancy 2. untreated pneumothorax
safety trial of patient specific guides for lumbar fusion

Conditions: Orthopedic Disorder of Spine

Summary: this is a single centre, non-blinded safety trial. patients undergoing lumbar fusion will be treated using patient specific guides (psg) or navigation. patients requiring lumbar fusion will be treated using conventional surgical methods except when inserting pedicle screws, where half of the patients will be having screws inserted using psgs. the conventional method of navigation and intraoperative imaging will be used in conjunction with psgs, to confirm the safety of the guide trajectory. the primary outcome will be screw accuracy measured in degrees from planned trajectory and mm from the planned entry point.


Eligibility criteria:
inclusion criteria: * age 18 years or over * indication for lumbar spine surgery requiring pedicle screw instrumentation through a posterior approach with fusion. * recently has or requires a ct-scan of the spine * no previous spine surgery on the level being used for patient specific guides * sufficient understanding of the english language or interpretation assistance available. exclusion criteria: * history of alcohol or drug abuse * history of psychiatric disorders * previous spine surgery adjacent or at the level of the surgery * unable to read or comprehend the consent form/letter of information

Keywords: patient specific guides lumbar fusion spine
the effects of sandalwood aromatherapy on anxiety levels of pediatric

Conditions: Anxiety, Dental

Summary: aim of the study: evaluate the anxiety in the child before treatment. detection of the sandalwood and lavender oil effect on dental anxiety.

anxiety is a kind of emotional disorder associated with unexpected or considered dangerous situations. physiological signs that can be observed are sweating, increased blood pressure, tachycardia, dry mouth, diarrhea, muscle tension, and hyperventilation. the prevalence of anxiety for worldwide dental patients is considered high, reaching 6-15% of the population and usually starting from childhood (51%) and adolescents (22%). a study showed that 25% of primary-school-age children undergoing dental treatment experienced severe anxiety, 50% moderate anxiety, and 20% mild anxiety. aromatherapy is a relaxation therapy media that uses aromatic essence extracts from plant parts. aromatherapy is used to treat and improve physical and psychological health. aromatherapy essential oil stimulates receptors in the nose, then the information is transmitted further to areas in the brain that control emotions and provide information to the hypothalamus, which is a regulator of the internal system of the body so that it reacts to stress. sandalwood is one of 22 species of the genus santalum in the world and is a commercial species through santalol oil that is widely used as a feedstock for aromatherapy. sandalwood has a distinctive aroma. this aroma comes from the main content of sandalwood, santa lol. the quality of sandalwood oil is determined by the content of a-santalol and p-santalol. a-santalol and p-santalol are sesquiterpene organic compounds. through aromatherapy, sandalwood oil is widely used to relieve anxiety, stress, and depression. this oil has neuroleptic, calming, and bronchial dilatation effects. this study aims to analyze sandalwood aromatherapy's effect on the anxiety level of pediatric patients undergoing dental treatment. the analysis was seen through three indicators of anxiety, namely systolic blood pressure, diastolic blood pressure, and heart rate per minute.

Eligibility criteria:
inclusion criteria: 1. egyptian children from 6 to 12 years old undergo primary tooth extraction. 2. absence of any systemic problems, physical and mental disabilities. 3. children intellectually sufficient to complete the anxiety scale and those whose parents were willing to participate in the study. 4. frankel rating 3 in cooperation. exclusion criteria: 1. presence of dental or medical emergency and systemic disorders. 2. special needs children. 3. children with any respiratory tract illnesses, common cold, or allergy.
helix research network

Conditions: Genetic Predisposition to Disease; Genetics Disease

Summary: the helix research network ("hrn") is a network of academic, public, and/or private healthcare organizations that are committed to advancing medical research and improving human health through large-scale genomics research and acceleration of the integration of genomic and other omics data into clinical care.

the network will create a large-scale clinicogenomics dataset, which will support research to discover molecular and genetic determinants of disease risk, disease progression, treatment response, health economic outcomes, social or behavioral determinants of health, targets for therapeutic intervention, risk stratification, clinical implementation, and other clinical indicators of interest. this clinicogenomics dataset will be used to reveal molecular and/or genetic factors that could improve the diagnosis or medical treatment of individual participants and includes a process to share individual results with participants. participants will also receive annual reports on study outcomes and the impact of hrn, as such information becomes available. institutional membership in hrn will consist of helix and member healthcare systems (herein referred to as "hrn member site(s)"). the helix research network is a multi-center research program that will enroll an unlimited number of participants. participants will be recruited concurrently from hrn member sites. in some cases, hrn member sites may recruit participants from multiple clinical sites. participants who meet the enrollment criteria established in this protocol will be enrolled if they or their legally authorized representative(s) provide informed consent in accordance with all applicable regulations and sirb requirements. participants will be enrolled until withdrawal from the study or end of the study. participants may be recruited at any point during the study period, until the recruitment goals established by the protocol are met.

Eligibility criteria:
inclusion criteria: * 18 years and older * willing and able to comply with all aspects of the protocol exclusion criteria: * history of allogenic bone marrow transplant * history of allogenic stem cell transplant * anything that would place the individual at increased risk or preclude an individual's: 1) full compliance with study requirements; or 2) completion of the study based on the assessment from local consenting and enrolling investigators.
weight management skills in african american outpatients

Conditions: Obesity

Summary: our long-term goal is to identify new insights about effective approaches to obesity management and related lifestyle changes in african americans and about factors that enhance or limit the response to specific treatment approaches. our primary interest is in "natural social support" from family members or friends. however, since not all individuals seeking obesity treatment desire or are able to name family members or friends to participate with them, we will also study the benefits of social support by creating a "team" condition among individuals recruited alone. specific aims are to: 1. recruit overweight or obese "index" participants together with 1 or 2 family members or friend co-participants who are also overweight or obese, for enrollment in a 2 year weight loss program; 2. conduct a randomized comparison of the effects, on weight loss and related behavioral and clinical outcomes of the index participants, of involving both index and co-participants (group a) in the counseling program with those obtained when co-participants are not directly involved (group b); 3. enroll otherwise eligible index participants who do not name co-participants in a parallel 2 year weight loss study; conduct a randomized comparison of the effects, on weight loss and related behavioral and clinical outcomes of individual participants, of creating social support teams of unrelated individuals (group c) with those obtained when no such teams are created (group d). primary hypotheses are that: 1. weight loss from 0 to 12 months and from 0 to 24 months will be significantly greater in group a vs. group b; 2. weight maintenance from 12 to 24 months will be significantly greater in group a vs. group b; 3. weight loss from 0 to 12 months and from 0 to 24 months will be significantly greater in group c vs. group d; 4. weight maintenance from 12 to 24 months will be significantly greater in group c vs. group d. secondary analyses will compare the respective treatment and control groups on changes in diet, physical activity, and clinical cvd risk factor changes over time and will assess predictors of outcomes and cost-effectiveness.


Eligibility criteria:
inclusion criteria: * african american men and women * ages 35-70 years * body mass index 27-54 exclusion criteria: * pregnant * taking weight altering medication

Keywords: african americans weight control social support
thrombus imaging and treatment analytics in neurology

Conditions: Thrombus, Brain; Thrombosis

Summary: in the present study, the investigators use high-resolution mr vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.

cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. there are few biomarkers to evaluate arterial thrombophilia until now. previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution mr vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. the study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * extracranial and/or intracranial artery occlusion confirmed by angiography * available for magnetic resonance high-resolution vessel wall imaging * written informed consent obtained exclusion criteria: * extracranial and/or intracranial artery mild to moderate stenosis * pregnant women * restenosis or occlusion after artery stenting placement

Keywords: thrombus neuroimaging high-resolution vessel wall imaging cerebral ischemia cerebral artery
pet scan in treating patients with metastatic prostate cancer

Conditions: Prostate Cancer

Summary: rationale: new imaging procedures, such as pet scan, may improve the ability to detect new or recurrent prostate cancer.

objectives: * measure the pharmacokinetics, whole body retention of isotope, and biodistribution of c11-methionine and fdg by pet imaging and serial sampling of blood in men with progressive prostate cancer. * explore metabolism of each pet scan by comparing the sensitivity of c11-methionine or fdg by pet scanning in androgen independent prostate cancer metastases with the sensitivity of c11-methionine or fdg in androgen dependent metastases on a site by site basis. * compare c11-methionine and fdg pet scanning to standard of care diagnostic studies which include the tc 99m bone scan, computed tomography, and magnetic resonance imaging. patients fast for 6 hours prior to pet imaging with the exception of liberal water intake which is encouraged. a two way catheter is placed in the urinary bladder, and continuous isotonic saline irrigation is performed throughout scan acquisition to reduce the interference in imaging lesions in the pelvic lymph nodes and adjacent pelvic bones caused by radiation excreted in urine held in the bladder. each patient receives c11-methionine intravenously. pet imaging begins immediately after injection for approximately 60 minutes total using standard imaging procedures. immediately following the completion of imaging after c11-methionine administration, each patient receives fdg intravenously. pet imaging begins approximately 45 minutes thereafter for approximately 60 minutes using standard imaging procedures.

Eligibility criteria:
disease characteristics: * histologically confirmed prostate adenocarcinoma * must have an at least 50% increase in psa which is sustained for a minimum of 3 observations obtained at least 1 week apart * must have development of new lesions on bone scintigraphy or greater than 50% increase in measurable disease on ct or mri scan * metastatic disease patient characteristics: age: * not specified performance status: * karnofsky greater than 60% hematopoietic: * anc greater than 1,000/mm\^3 * platelet count greater than 100,000/mm\^3 hepatic: * not specified renal: * not specified cardiovascular: * no clinically significant cardiac disease pulmonary: * no clinically significant pulmonary disease other: * no active infection not controlled by antibiotics prior concurrent therapy: biologic therapy * not specified chemotherapy * not specified endocrine therapy * not specified radiotherapy * not specified surgery * not specified

Keywords: adenocarcinoma of the prostate stage iv prostate cancer recurrent prostate cancer
automatization of counting procedures in children with dyscalculia

Conditions: Dyscalculia

Summary: researchers in numerical cognition usually think that the greatest and most common difficulty in children suffering from dyscalculia is retrieval of arithmetic facts from long-term memory. however, we have recently shown that retrieval might not be the optimum strategy in mental arithmetic. in fact, expert adults would rather solve simple problems such as 3 + 2 by automated and unconscious procedures. therefore, we hypothesize that children with dyscalculia might not present deficit in retrieval but, instead, in counting procedure automatization. the aim of the current project is to test this challenging position. through a longitudinal approach, we plan to precisely examine the behavior of children suffering from dyscalculia over a 3-year period. children will be aged between 8 to 11 years at the beginning of the study and we will precisely observe the evolution of their solution times when they solve simple addition problems involving one-digit numbers. if children with dyscalculia still struggle with simple additions three years, their solution times plotted on the sum of the problems should still follow an exponential function. indeed, if counting is not automated, difficulties necessarily increase with the progression on the number line or the verbal sequence, hence the exponential function. on the contrary, if counting procedures tend towards automatization, moves along a number line will progressively become as easy at the beginning of the line as at the end, hence the linear function. importantly, a retrieval model would predict exactly the inverse pattern because, according to this model, the linear function, which is unanimously considered as the hallmark of counting procedures, should progressively be replaced by a non-linear function through practice.


Eligibility criteria:
inclusion criteria: * age between 8 and 11 years old * having a dyscalculia as described in the dsm (diagnostic and statistical manual) v exclusion criteria: * presenting a global intellectual deficit

Keywords: dyscalculia
imaging colo-rectal cancer using a two step antibody technique in nuclear imaging

Conditions: Colonic Neoplasms

Summary: the purpose of this study is to test the safety of the peptide and antibody and at the same time evaluate the tumor imaging of a two step antibody technique in nuclear imaging.

colo-rectal cancer has an incidence of 8000 cases per year in the netherlands. eventually 50% of them will die as a consequence of this disease. treatment consists of resection of the primary tumor, followed by adjuvant chemotherapy in some patients. the chemotherapeutical agents, however, are only moderately effective with regard to increase of survival. new treatment modalities are therefore desirable. radioimmunotherapy using radioactive labelled antibodies have proven to be effective in hematologic malignancies. due to slow absorption in solid tumors however an effective radiation dose is not yet achieved. the aim of our study is to bypass this slow tumor uptake by the use of pre-targeting. we therefore use an unlabeled bispecific antibody infusion. this will be followed several days later by the infusion of a radiolabeled peptide that binds to the bispecific antibody. we hypothesise that this small peptide will be readily absorbed by the tumor which is pre-saturated by the bispecific antibody. as a consequence a higher radiation dose can be given with a lower toxicity.

Eligibility criteria:
inclusion criteria: * \> 18 years of age * histologic or cytologic diagnosis of colorectal cancer * karnofsky performance status \>70% exclusion criteria: * pregnant or lactating women * severe anorexia * active second primary malignancy * chemotherapy or radiotherapy within four weeks of study entry

Keywords: colon cancer radioimmunoscintigraphy colon-specific antigen, radioimmunotherapy, radioimmunodetection
high intensity interval training or strength training in women with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: the aim is to investigate whether strength training or high intensity interval training is effective in improving insulin sensitivity, cardiovascular outcomes, body composition and reproductive outcomes in women with polycystic ovary syndrome (pcos). few studies have examined the effect of strength training alone on insulin sensitivity, reproductive outcomes and body composition in women with pcos. most previous studies on aerobic exercise in pcos have applied moderate exercise intensity.


Eligibility criteria:
inclusion criteria: * women * age 18-45 years old * pcos exclusion criteria: * regular high intensity endurance or strength training (two or more times per week of vigorous exercise). * concurrent treatments (insulin sensitizers or drugs known to affect gonadotropin or ovulation, with a wash out period of 1 months prior to inclusion). * on-going pregnancy.

Keywords: exercise resistance training insulin resistance high intensity interval training
changes of depression after first-year of tofacitinib in ra patients

Conditions: Rheumatoid Arthritis

Summary: 12-month, single arm, prospective, non-interventional, multi-center study according to czech legal definitions (law 378/2007 sb.).the primary objective of this study is to describe and evaluate the changes of depression level within 12 months from the start of tofacitinib therapy in patients with ra and at least minimal level of depression. primary goal is to find out if treatment by tofacitinib reduces the depression by at least 10% during 12 months.


Eligibility criteria:
inclusion criteria: * patients aged ≥18 years. * moderate to severe activity of rheumatoid arthritis (das28 ≥3.2). * patient for whom the physician decision has been made to initiate a treatment with tofacitinib. * patient with at least minimal level of depression (cudos questionnaire ≥11 points). * capable of understanding and signing a written informed consent form. * evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study is a requirement for inclusion into this study. exclusion criteria: * patients unwilling/unable to fill in printed patient questionnaires.
assessment of the risk of contralateral non simultaneous neck of femur fracture in the elderly.

Conditions: Neck of Femur Fracture

Summary: neck of femur fractures are common in the elderly and are the source of significant morbidity and mortality. this study is based on a new technique developed in ben gurion university, with which investigators are able to asses the structural 3 dimensional strength of a bone by applying a unique simulation on a cat scan of the bone. the purpose of this study is to evaluate the risk of a contralateral neck of femur fracture after the first neck of femur fracture and to estimate the potential fracture characteristics.

neck of femur fractures are common in the elderly and are the source of significant morbidity and mortality. literature shows that around 10 percent of those who fracture their femoral neck for the first time will later fracture their contralateral neck of femur and in most cases with the same fracture characteristics. this study is based on a new technique developed in ben gurion university, with which investigators are able to asses the structural 3 dimensional strength of a bone by applying a unique simulation on a cat scan of the bone. the purpose of this study is to evaluate the risk of a contralateral neck of femur fracture after the first neck of femur fracture and to estimate the potential fracture characteristics.

Eligibility criteria:
inclusion criteria: * 70-90 years old patients admitted to the orthopaedic department after neck of femur fracture. * no contra lateral femur pathology. * consent for pelvis and femurs cat scan. exclusion criteria: * known pathology in other lower limbs joints in the body. * history of previous fractures or operations in lower limbs.