Kornimate/medical-research-clean huggingface dataset:
contagious misinformation trial

Conditions: Misinformation

Summary: in the contagious misinformation trial the investigators aim to debunk prevalent misinformation about an infectious disease using two evidence-based methods of debunking. the two debunking methods are packaged in two audio dramas of 4 episodes each, which will be sent to the whatsapp of participants who are randomised to intervention group 1 or 2. the control group will receive audio messages about a different topic. the primary outcome is the reduction in belief in two misinformation statements about the infectious diseases.


Eligibility criteria:
inclusion criteria: * adults * living in freetown * in possession of a mobile phone that has whatsapp * fluent in krio exclusion criteria: * deafness

Keywords: misinformation communication infectious diseases
study comparing abx-cbl (monoclonal antibody) versus atgam in patients with steroid resistant acute graft versus host disease

Conditions: Graft Vs Host Disease

Summary: trial evaluating the improvement in survival at 180 days of two therapies (atgam versus abx-cbl, a monoclonal antibody) in patients with acute graft versus host disease that does not respond to steroid therapy.


Eligibility criteria:
inclusion criteria: * recipient of single allogeneic stem cell transplant from any donor type * time post transplant less than 100 days * received no treatment for gvhd other than steroids exclusion criteria: * recipient of second allogeneic stem cell transplant or subsequent lymphocyte product from the donor post transplant * ibmtr index less than a * received any murine product in the past * diagnosed with chronic gvhd * received atgam later than day 10 post transplant * change to prophylactic regimen for acute gvhd within 72 hours of randomization

Keywords: acute graft versus host disease stem cell transplantation
use of valproid acid to treat tropical spastic paraparesis/htlv-1-associated myelopathy (tsp/ham)

Conditions: Paraparesis Spastic Tropical

Summary: is the valproic acid efficacy to treat tsp/ham


Eligibility criteria:
inclusion criteria: * htlv-1; tsp/ham fulfill criteria exclusion criteria: * age \<18 years

Keywords: tsp/ham, htlv-1, treatment
intimacy of women with cystic fibrosis

Conditions: Mucoviscidosis

Summary: the intimate life of patients with cystic fibrosis has not been the subject of specific research, it is even left behind in favor of respiratory, digestive or endocrinological dysfunctions endangering these patients. after 16 years of practice, it is significant that this subject is problematic, painful but difficult to tackle; no doubt just as much on the side of caregivers: this question has never found its way into team exchanges, it seems to be evaded doubtless difficult or too intimate to welcome. these disorders arise from the effects of the disease on the health of the mucous epithelial tissues also located in the genital area. these difficulties are more closely approached by the difficulties of procreation; pma allows them to get around them, nevertheless making it possible to be a parent, with the residual frustration of a satisfactory sex life: a deaf "addition", adding to many care constraints. it is therefore in terms of sexual health and quality of sexual life that it is desirable to shed light on this aspect of cystic fibrosis in women. bibliographic research confirms this approach: this subject is not explored, the rare publications concern the vulnerability of the cervix or the difficulty on both sides of tackling this subject.


Eligibility criteria:
inclusion criteria: * major women with cystic fibrosis * tracked in the various crcms in france, * having or having had sexual intercourse, * having previously been informed of the aims and confidentiality of this research and not having opposed their participation. exclusion criteria: * major women with cystic fibrosis whose state of health (acute episode of their disease or worsening phase) does not lend itself to such a collection * adult women with cystic fibrosis who are unable to receive the information and make a non-objection

Keywords: cystic fibrosis women private life sexual disorders quality of sex life
wheeze detection in adults during dynamic bronchial situations measured by pulmotrack® 2010 with wim-pc™ technologies recording

Conditions: Asthma, Bronchial

Summary: the pulmotrack® 2010 with wim-pc™ technologies device, indicated for acoustic pulmonary function measurement that quantifies the presence of wheezing. this study was designed in order to evaluate the efficacy and safety of using the wim-pc™ device for wheeze detection during dynamic bronchial situations in asthmatic adult.

asthma is defined by the national asthma education and prevention program (naepp) guideline as a 'chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. the asthma guideline states that inflammation causes recurrent episodes of wheezing, breathlessness and chest tightness that are associated with widespread but variable airflow obstruction. wheeze quantification by lung sounds analysis methods is objective, non invasive and has been shown to correlate with clinical status in asthma and bronchiolitis. the recording procedure is simple, requiring only the attachment of 4 ecg-size sensors to the chest wall. a 30-second recording is often adequate to obtain good quality data, where wheezes are detected and counted with high degree of accuracy. karmel sonix ltd has developed the pulmotrack® 2010 with wim-pc™ technologies device, indicated for acoustic pulmonary function measurement that quantifies the presence of wheezing. this study was designed in order to evaluate the efficacy and safety of using the pulmotrack® 2010 with wim-pc™ technologies device for wheeze detection during dynamic bronchial situations in asthmatic adults.

Eligibility criteria:
inclusion criteria: * asthmatic or healthy subjects; * age 18 and up; * not smoking for at the last two years; * subject or subject's parents/guardian is able to comprehend and give informed consent for participation in the study. exclusion criteria: * chest burns; * copd; * pregnant or lactating; * mechanically ventilatory; * homodynamic instability; * unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months prior to screening; * acute infection requiring intravenous antibiotics at the time of screening; * uncontrolled bleeding and coagulation disorders; * uncontrolled diabetes mellitus: iddm or niddm; * hiv positive or any other immunosuppressive disorder; * subject objects to the study protocol; * concurrent participation in any other clinical study; * physician objection.

Keywords: wheeze detection
the national early warning score: preceding dynamics in the score for those who suffer an in-hospital cardiac arrest

Conditions: Rapid Response System; Vital Signs

Summary: to this date no clinical evaluation reports of the dynamics in the national early warning score (news) for those patients who suffer an in-hospital cardiac arrest, ihca, exists. this process needs to be investigated in order to optimize the future care of these patients. research questions h1: patients that suffer an ihca has had higher news in the preceding 24 hours from the event compared to those who did not suffer an ihca. h2: the dynamics in the news, differs between the patients that suffer an ihca and those who do not in the preceding 24 hours from the event.

power: a sample size of 300 patients in the control group and 150 patients in the group that suffered from an ihca would generate a power estimate of 80 percent if the difference in the median is one point on the news with a standard deviate of three points. analysis of the research data: categorical and nonparametric data will be presented in median (25-75 percentiles). a hypothesis testing will be performed where the documented news will be categorized into low-, medium- and high-risk and divided into different timespans. the timespans will be 0-6 h, 6-12 h, 12-18 and 18-24 h preceding the ihca. in case of multiple news measurements within each timespan, the worst news measurement will be chosen. each timespan during the 24 hours will not be treated as repeated measures and will be tested by the chi square test. this test is chosen because the data is categorical. another hypothesis test where all the news measurements will be included and each documented news on the same patient will be treated as repeated measures. a binary logistic regression analysis will be performed using generalized estimating equations (gee) and modelled to fit. in order to select the covariates that is to be included in the regression analysis a non-parametric test including all the parameters in the news will be executed. the level of significance for this test will be set to p=0.2 2. collinearity within the news parameters that is to be included in the regression analysis will be tested. the level of collinearity that is accepted will be \ -0,6. a binomial logistic regression analysis will be executed with the selected parameters in the news the outcome of the regression analysis will be presented as odds ratio (or).

Eligibility criteria:
inclusion criteria: all patients ≥18 years of age admitted to the hospitals during a period of 12 months will be reviewed for eligibility exclusion criteria: -

Keywords: national early warning score rapid response system
carpal tunnel syndrome treated with 830nm diode laser

Conditions: Carpal Tunnel Syndrome

Summary: the purpose of this study is to determine that 830nm diode laser directly above the transverse carpal ligament (between the pisiform and navicular bone) on subjects' wrists, and test this therapeutic effect.

the low level laser instrument (painless light pl-830, advanced chips \& products crop., usa) emitted two light beams with a distance of 2.5cm between them by two laser diodes.

Eligibility criteria:
inclusion criteria: * no operation of the wrist * first onset of cts more than 1 year ago with repeated episodes * never having laser treatment before. exclusion criteria: * patients with any rheumatoid arthritis * history of metabolic disease or paralyzed limbs caused by stroke * taking any anti-inflammatory drug * with other treatments, such as acupuncture, physical therapy and wearing orthosis
association of plasma transfusions and invasive fungal infection

Conditions: Plasma Administration; Invasive Fungal Infection; Neonatal Infection

Summary: although lacking strong evidences, plasma transfusions are commonly used in critically ill neonates. to date, the relationships between plasma transfusions and nosocomial infection remain controversial and no study has reported the relationships between plasma transfusion and invasive fungal infection (ifi)

our aim is to explore the association between plasma transfusions and ifi in critically ill neonates

Eligibility criteria:
inclusion criteria: * all critically ill neonates admitted in hospital exclusion criteria: * severe congenital abnormality; * died within 24 hours or left neonatal intensive care unit within 24 hours according to their parents' decisions; * parents' decision not to participate.
m3vas validation in polish population

Conditions: Depressive Disorder

Summary: low mood and anhedonia represent the fundamental symptoms of major depressive disorder (mdd). nevertheless, there is currently no standardized visual analogue scale available to assess the extent of both symptoms concurrently. the maudsley 3-item visual analogue scale (m3vas) is a newly developed tool for participants to self-assess core symptoms of depression: mood quality, pleasure experience (anhedonia), and suicidality. despite suicidality not being a primary symptom, it is included due to its critical relevance to safety. participants will be instructed to rate the intensity and frequency of their experiences over the preceding two weeks by marking a 100 mm ungraded line. a researcher will then assign a numerical value based on the mark's position, utilizing the left edge as 0 and the right as 100. the total score range, combining the three symptoms, ranged from 0 (minimum) to 300 (maximum). the m3vas exhibited good psychometric properties in british population. in this study, the objective is to assess the psychometric properties of the scale within the polish population diagnosed with major depressive episode within major depressive disorder or bipolar disorder.


Eligibility criteria:
inclusion criteria: diagnosis as provided by dsm-5 criteria: major depressive disorder (mdd) bipolar disorder (bd) exclusion criteria: diagnosis as provided by dsm-5 criteria: psychotic disorders current mania or hypomania within bipolar disorder (bd)

Keywords: anhedonia; low mood; suicidality; depression; m3vas
feasibility of mid-frequency ventilation in newborns with rds: randomized crossover pilot trial

Conditions: Respiratory Distress Syndrome, Newborn

Summary: respiratory distress syndrome (rds) is the most common respiratory disorder in preterm infants. despite improved survival of extremely premature infants with rds, complications related to mechanical ventilation still occur. this trial will attempt to maintain adequate gas exchange at a rapid rate, short inspiratory time, low tidal volume, and low peak inspiratory pressure in infants with respiratory distress requiring mechanical ventilation. a cross over design will be used to test the hypothesis whether mid-frequency ventilation in preterm infants with rds requiring mechanical ventilation will reduce the peak inspiratory pressure requirement when compared to conventional mechanical ventilation.


Eligibility criteria:
inclusion criteria: * inborn newborn infants with birthweight greater than or equal to 500gms, with gestational age greater than or equal to 24 weeks but less than or equal to 36 weeks. * postnatal age less than or equal to 7 days. * infant with respiratory distress syndrome (rds) on mechanical ventilation with less than or equal to 60 breaths/minute, initially requiring greater than or equal to 30% fio2. * written informed consent. exclusion criteria: * blood culture positive sepsis, life threatening congenital anomalies, cyanotic congenital heart diseases, hydrops fetalis, outborn infants, non viability as determined by the attending physician, and newborns who are considered too unstable for study enrollment as per neonatology attending/fellow.

Keywords: conventional mechanical ventilation mid-frequency ventilation respiratory distress syndrome preterm newborn infant mean airway pressure mean arterial pressure mean peak inspiratory pressure
a comparison of emtricitabine and abacavir used in a three-drug combination in hiv-infected patients who have never taken anti-hiv drugs

Conditions: HIV Infections

Summary: this study will look at whether emtricitabine is as safe and effective as abacavir (abc) when taken with stavudine (d4t) and efavirenz (efv) in patients who have never taken anti-hiv drugs.

patients are randomized to receive open-label emtricitabine or abc in combination with stavudine and efavirenz. viral load and cd4+ cell counts are compared at weeks 24 and 48. patients are followed for 48 weeks.

Eligibility criteria:
inclusion criteria you may be eligible if you: * are hiv-positive and generally healthy. * have a viral load of 5,000 copies/ml or more. * have cd4 cell counts of 200 cells/mm3 or more. * are age 18 or older. * agree to practice sexual abstinence or use effective barrier methods of birth control (such as condoms). exclusion criteria you will not be eligible if you: * have ever taken anti-hiv drugs for 3 days or more. * have had certain aids-related infections. * have had severe diarrhea within the past 30 days. * are unable to eat at least 1 meal a day due to nausea, vomiting, or stomach pain. * are being treated for active tuberculosis (tb). * are pregnant or breast-feeding. * use illegal drugs or alcohol that make it difficult for you to take study drugs or keep clinic appointments. * are taking certain medications, or have certain other conditions or diseases (see the technical summary for more detail).

Keywords: dideoxynucleosides drug therapy, combination stavudine reverse transcriptase inhibitors abacavir efavirenz
comparison of nasal steroids after fess in crswnp

Conditions: Sinusitis; Nasal Polyps

Summary: the purpose of this study is to compare intranasal fluticasone spray with budesonide nasal saline rinses in both the upright and head forward positions in patients who have had functional endoscopic sinus surgery (fess) for chronic rhinosinusitis with nasal polyposis (crswnp) and measure differences in sinonasal outcome test-22 (snot-22) scores and lund- kennedy scores on rigid nasal endoscopy at time points 1 week, 3 weeks, 6 weeks, 2 months, 4 months, and 6 months post-op.

chronic rhinosinusitis (crs) is an inflammatory condition of the lining of the nose and sinuses that lasts 12 weeks or longer with objective evidence of mucosal inflammation (1). crswnp is characterized by the presence of bilateral nasal polyps in the middle meatus. patients with crswnp for whom medical therapy has failed, often have functional endoscopic sinus surgery. nasal steroids are important post-operatively to prevent polyps from recurring. many studies have shown that nasal steroids are superior to placebo in maintaining improvement in symptom scores, such as snot-22, post-operatively by preventing polyps from returning (2). nasal steroids can reduce inflammation locally and can prevent disease relapse without the systemic effects of oral steroids. however, there is no consensus as to which nasal steroid and which delivery method is most effective in treating these patients. traditional nasal sprays, such as fluticasone spray, may not deliver the medication widely in the nasal cavity. budesonide is available in a respule form that can be used to instill the medication in the nose. in an attempt to more effectively deliver the medication, changes in patient's head position has been prescribed to achieve better delivery (3). the safety of intranasal budesonide, a more potent steroid than fluticasone, has been established (4, 5). however, any improved efficacy over fluticasone nasal spray remains anecdotal as head to head comparisons have not previously been performed. practice patterns among rhinologists in the post-operative prescription of nasal steroids vary widely. determining which medication/delivery method is more effective will help rhinologists better treat their patients and prevent symptoms, for which the surgery was performed, from returning.

Eligibility criteria:
inclusion criteria: * adult patients who have had fess for crswnp within the study period exclusion criteria: 1. patients who are under the age of 18 2. concurrent oral corticosteroid use of the equivalent of greater than 10 mg of prednisone use per day 3. the use of medications that accelerate the clearance of systemic cortisol (dilantin, rifampin, amphetamines, and lithium) 4. the use of medications that inhibit the clearance of systemic cortisol (ketoconazole, amphotericin b, bupropion, fluoroquinolones) 5. known hypersensitivity to corticosteroids 6. a personal history of wegener's granulomatosis or other autoimmune disease with nasal manifestations

Keywords: chronic rhinosinusitis with polyps nasal steroids functional endoscopic sinus surgery snot-22 lund-kennedy
effect of chrysanthemum flower oil and its dose-dependency on hyperuricemia

Conditions: Hyperuricemia

Summary: the aim of this study is to investigate the efficacy and dose-dependency of chrysanthemum flower oil in suppressing serum uric acid.


Eligibility criteria:
inclusion criteria: * serum uric acid 6.8-8.9 mg/dl exclusion criteria: * taking anti-hyperuricemic drugs * history of gouty attack * taking drugs or functional food that may affect serum uric acid level * hypertention, hyperlipidemia, or diabetes millitus * participation in any clinical trial within 90 days of the commencement of the trial * renal or hepatic dysfunction * heart disease * history of severe disease and/or major surgery
effect of the intervention "food, fun and family" on sleep bruxism in children

Conditions: Sleep Bruxism, Childhood

Summary: excess consumption of refined sugar and increased use of recreational screen time are risk factors for alterations in the quality of life that have been associated with sleep bruxism in children and that compromise the same mechanisms of alteration of the reward system in the brain. therefore, the question of this research is: what is the effect of the intervention "food, fun and family (fff)" on the frequency of sleep bruxism in children? the general objective of the research is to evaluate the effect of the intervention "food, fun and family (fff)" on the frequency of sleep bruxism in 84 children who attend the pediatric dentistry postgraduate clinic of the ces university and the private consultation dr. claudia restrepo and dr. adriana santamaría. the frequency of sleep bruxism will be evaluated with the translated and validated spanish version of the children's sleep habits questionnaire (cshq), which will be answered by the parents. the consumption of added sugar will be evaluated with the version translated into spanish of the health behavior in school-aged children - food-frequency questionnaire (hbsc-ffq). the time on screens will be recorded through the parents' report, of the time in hours that the child spends using electronic media in a recreational way each weekday for a week and each weekend day for a week. a decrease in the frequency of sleep bruxism is expected to be found by reducing sugar consumption and screen time in the children evaluated. the results of this study will be presented at the iadr, acfo, acop and ces university research meetings and will be published in a peer-reviewed scientific journal in category q1.


Eligibility criteria:
inclusion criteria: * children who eat breakfast, lunch and dinner at home. * children whose feeding and habits management (upbringing) is in charge of the same group of representative adults. * children who live with their parents. * children attending the consultation for the first time. exclusion criteria: * symptoms of respiratory disorders reported by parents in the cshq. * food allergies. * special diet restrictions. * developmental disorder influencing diet or weight. * basic endocrinological diseases. * being under endocrinological treatment. * previously diagnosed sleep disorders. * children who miss more than two assigned appointments. * parents of children who withdraw informed consent. * children who are diagnosed during the study with respiratory disorders. * children who are diagnosed during the study with food allergies. * children who for personal reasons cannot continue in the study.

Keywords: children sleep bruxism added sugar screen time