Kornimate/medical-research-clean huggingface dataset:
research based on iolmaster700 cataract diagnosis and classification system

Conditions: Cataract; Artificial Intelligence (AI)

Summary: cataract is a major cause of blindness due to eye diseases. methods for evaluating the degree of lens opacification in cataracts are divided into subjective and objective methods. the commonly used subjective method is the lens opacification classification system (locs ⅲ), while the objective methods mainly include the dysfunctional lens index (dli) of the ray tracing aberration analysis system, the pns score of the pentacam anterior segment analysis system, etc. subjective diagnosis may lead to certain misjudgments, which have affected clinical diagnosis and treatment. there is an urgent need to add objective diagnostic measures to assist clinical work. the scanning source optical coherence tomography (ss - oct) biometer - iol master 700 forms an oct imaging of the eye based on the swept - source optical coherence tomography (oct) biometric technology. it can visually show the longitudinal section of the entire lens, and the clear display of the patient's lens tomographic oct image is obtained through image visualization measurement. the main purpose of this study is to analyze the lens images obtained by the iolmaster 700. based on the current mainstream algorithm models such as resnet - 34 and xgboost, develop a heterogeneous accelerated artificial intelligence algorithm according to our research needs to accurately calculate the degree of lens opacification. and write image analysis software by ourselves to automatically calculate the required indicators and output them. establish a heterogeneous accelerated artificial intelligence - assisted lens opacification grading and prediction system, supporting software for biometer equipment, and a cataract lens image database. the software provides online service functions, and all researchers can use the image analysis function of the software after logging in, truly realizing the sharing of large instrument supporting software operations. thereby improving the accuracy and efficiency of clinical diagnosis and treatment, the prognostic prediction level of patients after cataract surgery, guiding clinical diagnosis and treatment more accurately, and at the same time, it can be used as a tool for community screening.


Eligibility criteria:
inclusion criteria: * a. age between 18 and 90 years b. diagnosed with age-related and/or complicated cataract (diagnosed according to locs iii classification) c. the patient has signed an informed consent form exclusion criteria: * a. exclude patients with corneal diseases, uveitis, vitreoretinal diseases, or refractive media opacities caused by conditions such as retinal detachment with silicone oil tamponade b. history of previous ophthalmic disease treatment or surgery c. poor-quality or missing imaging data d. pupil diameter \< 2.5 mm or loss of fixation during examination, resulting in inability to obtain sufficient lens data
determinants of bladder cancer recurrence study (the deter study)

Conditions: Bladder Cancer

Summary: the purpose of this study is to learn how different lifestyle factors, such as cigarette smoking and body weight, change after a diagnosis of bladder cancer, and how they influence who gets a bladder cancer recurrence and who does not.


Eligibility criteria:
inclusion criteria: * patients ≥18 years old and * histologically-confirmed non-muscle invasive bladder cancer (nmibc) exclusion criteria: * patients are ineligible for the study if they have/had: * histologically-confirmed nmibc diagnosed \>36 months prior to enrollment * cystectomy prior to enrollment * any condition, which in the opinion of the primary msk clinician or investigators precludes their ability to provide informed consent or comply with study procedures * non english-speaking

Keywords: msk tobacco cessation program smoking exposure 15-047
the association between pain catastrophizing scale score and postspinal headache

Conditions: Pain; Headache

Summary: this study is aimed to elucidate the association between pain catastrophizing scale score and postspinal headache in patients underwent cesarean section with spinal anesthesia.

this study is aimed to elucidate the association between pain catastrophizing scale score and postspinal headache in patients underwent cesarean section with spinal anesthesia. patients were asked to fill the questionnaire booklet including pain catastrophizing scale, beck depression inventory and beck anxiety inventory before elective cesarean section in preoperative room in operating theater. in postoperative second and fourth day, patients will call by phone and be asked to have headache or any complaints. the intensity of headache will evaluate by using visual analog scale. age, gender, and visual analog scale scores will be recorded.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists score of i, ii, iii * without a history of cerebrovascular diseases * without any presence of psychiatric diseases exclusion criteria: * severe liver, kidney and cardiovascular diseases * peripheral arterial diseases * a history of allergy to local anesthetics * patients without cooperation * not to participate in the study * presence of neurologic or neuromuscular diseases

Keywords: pain catastrophizing scale
meditation and education that is nurse delivered for symptom management in paroxysmal atrial fibrillation (paf)

Conditions: Paroxysmal Atrial Fibrillation

Summary: the aim of this project is to determine whether the entire intervention (mindfulness meditation, af education, and weekly phone visits) that is nurse delivered to individuals with paroxysmal atrial fibrillation is more effective than a combination, single or no intervention in the reduction of overall af symptoms, anxiety, and negative illness perception; or the improvement of quality of life (qol) and functional status.


Eligibility criteria:
inclusion criteria: 1. individuals with symptomatic paroxysmal atrial fibrillation 2. a symptomatic episode of paf within last 6 months 3. 18 years old or greater 4. able to read and understand english 5. able to participate in weekly phone calls 6. able to attend two video visit/phone sessions that are 6 weeks apart exclusion criteria: 1. diagnosed with low cardiac function (nyha class iv) 2. life expectancy of less than 6 months 3. hospitalized in prior 3 months for illness other than paf 4. previously practiced mindfulness 5. cognitive impairment

Keywords: symptom management quality of life anxiety
the effect of fascia iliaca compartment block (ficb) on qor-15 score in partial hip arthroplasty surgery

Conditions: Post Operative Pain; Anesthesia, Local; Fracture of Hip; QoR-15

Summary: it reduces pain scores in patients with block and improves the quality of recovery in the postoperative period. in patients who will undergo spinal anesthesia, it will be questioned whether the application of the block before or after surgery makes a difference in the quality of recovery.

american society of anesthesiologists (asa) physical status i-iii patients who are planned for partial hip arthroplasty will be studied in patients over 65 years of age. the patients will be equally randomized into two groups using a computer-generated random number table. in the preoperative period, according to whether fibp was before or after spinal anesthesia, it will be named as a separate group as group pres (pre-spinal) and group posts (post-spinal). the patient will be placed in the lateral decubitus position with the fractured side up. after the spinal anesthesia method was provided with aseptic conditions, 10 mg 0.5% isobaric bupivacaine + 20 mcg fentanyl injection will be applied using a 26 gauge pencil point needle through the l3-l4 or l4-l5 intervertebral space. after the patients are in the supine position and aseptic conditions are provided, the fascia on the iliacus muscle will be determined with the help of an 8-12 mhz linear probe, and the block will be applied with the in-plane technique. during the block, patients will routinely administer 0.2% bupivacaine concentration of 0.5 ml/kg. demographic data, operation time, perioperative analgesic and sedation need, postoperative pain scores, additional analgesic need, hospitalization and 24th-hour recovery scores will be evaluated.

Eligibility criteria:
inclusion criteria: * partial hip arthroplasty * american society of anesthesiologists (asa) physical status i-iii, * patients aged ≥ 65 years exclusion criteria: * contraindication for central or peripheral blocks, * cognitive dysfunction, * history of chronic opioid use, * previous hip surgery, * serious organ dysfunction, * allergy to any drug used in the study, * body mass index (bmi) ≥30, * infection in the area to be treated, * refusal to participate in the study

Keywords: fascia iliaca compartment block ficb partial hip arthroplasty surgery quality of recovery-15
observational study on changing the quality of life in daily life activities after clinical approach positioning the wheelchair

Conditions: Mobility Limitation; Wheelchairs

Summary: stemming from the common practice of attribution of the technical helps in the posture in canada, the multidisciplinary approach of positioning develops in france for more than 10 years old. to date, no observatory study was led to estimate the impact of such consultation in daily activities, an essential objective conditioning the observance and the acceptance of assistive devices. this study wants to estimate the impact through modification of whom scale.


Eligibility criteria:
inclusion criteria: * persons which are in wheelchair since more than 6 months, * no recent medical decompensation (\<1 mois) exclusion criteria: * recent medical decompensation
a test of the investigational sem scanner

Conditions: Pressure Ulcers

Summary: the objective of this study is to establish required data for sem scanner analysis of the readings given by the sem scanner in the target patient population.. in order to better understand the data this non-invasive scanner provides a collection of data/readings is required to be collected in a certain population. this will help with clinical interpretation of the numbers and readings this device will provide.


Eligibility criteria:
inclusion criteria: * subjects are 18 years of age or older. * subject or health care proxy is willing and able to provide informed consent for enrollment. * subject is agreeable to having skin assessments, blanchability tests, and sem scanner readings performed daily at all anatomical sites for a duration of five (5) days, with photography as needed. * subject is admitted to an intensive care unit (icu) and has an anticipated icu course of 48 hours or greater. * subject is not comfort measures only (cmo). * subject is anticipated to be bedridden for ore than 6 hours per day. * all four (4) of the subject's anatomical sites in question (sternum, sacrum, left heel and right heel) are accessible for scanning (e.g., no cast or medical device present such that heels are not accessible). exclusion criteria: * subject has broken skin or scar tissue at the sternum, sacrum, left heel or right heel. * subjects for whom the physical act of performing the inspections and measurements required in this study are contra-indicated, as determined by the principal investigator or attending physician. * subjects or legal representatives who are unable to understand the aims and objectives of the trial. * presence of any condition(s) which seriously compromise(s) the subject's ability to complete this study, or has a known history of poor adherence with medical treatment. * subject is pregnant. * subject is incarcerated.

Keywords: sub-epidermal moisture pressure ulcers
impact of cancer treatment on the pelvic floor function in survivors of cervical cancer

Conditions: Cervical Cancer; Pelvic Floor Disorders; Surgery; Radiotherapy; Complications; Chemotherapy Effect

Summary: introduction: pelvic floor muscle dysfunctions (pfmd) represent an important public health problem that manifests itself through lower urinary tract symptoms (luts), anorectal and sexual dysfunction. pfmd is a common problem in cervical cancer survivors (cc) with a negative impact on quality of life (qol). objective: this study aims to evaluate the effect of oncological treatment on the function of pelvic floor muscles (pfm) of survivors of cc. methods: patients diagnosed with cc, of any stage, histology and degree, accompanied by the oncology gynecology service of the hospital das clínicas of the medical school of ribeirão preto at the university of são paulo, will be studied in the period between 2004 and 2014. four study groups will be formed: (1) patients with cc with pfmd; (2) patients with cc without pfmd; : (3) patients without cc with pfmd; (2) patients without cc without pfmd. non-cancer patients will be recruited into the community. for the analysis of the prevalence of pfmd will be applied to the discomfort questionnaire on pelvic floor (idpe-20) for evaluation of pelvic organ prolapse (pop) complaints, anorectal symptoms and urinary incontinence, and the sexual questionnaire for urinary incontinence and pelvic organ prolapse (pisq -12) for evaluation of sexual function. both questionnaires have already been validated for the portuguese language and are specific for women with pfmd. the pelvic floor impact questionnaire (pfiq-7) will also be applied to assess the impact of pfmd on quality of life, daily living activities and emotional health. for the evaluation of general qol, the eortc questionnaire qlq-c30 and its specific module for patients with cc, qlq-cx24 will be used. the evaluation of pfm function will include vaginal palpation (modified oxford scale) and perineometry (peritron).


Eligibility criteria:
inclusion criteria: * women diagnosed with cc; no distinction as to age, race, scholarity and religion; women in follow-up at clinical hospital of medical school of ribeirão preto of university são paulo. exclusion criteria: * women who did not complete the proposed cancer treatment; women who presented cc as the second malignant neoplasm; pregnant women; failure to respond to the proposed questionnaires.

Keywords: cervical cancer pelvic floor muscles physiotherapy quality of life
javlor® online non-interventional trial

Conditions: Transitional Cell Carcinoma

Summary: documentation of data concerning tolerability and efficacy of the intravenous treatment with vinflunine performed under daily routine conditions in germany. the trial focusses on tolerability including the assessment of the usage of anti-emetic and anti-obstipative concomitant treatment as well as on the efficacy of the treatment.


Eligibility criteria:
inclusion criteria: * at least 18 years old * legally competent male and female patients * advanced or metastatic transitional cell carcinoma of the urothelium * failure of a prior cisplatinum-containing treatment * performance status 0 or 1 * signed patient informed consent exclusion criteria: * missing signed patient informed consent * performance status 2 or higher * life expectancy \< 2 months * brain metastases * creatinine-clearance \< 20 ml/min * child-pugh-stadium c * prothrombin time \< 50% * bilirubin \> 5 x uln * transaminases \> 6 x uln * gamma-glutamyl-transferase \> 15 x uln * pregnant or breast-feeding women * known/suspected hypersensitivity against vinflunine or other vinca-alkaloids * recent (within the last 2 weeks) or current severe infections * baseline anc \< 1,500/mm3 or platelets \< 100,000/mm3 * patients being institutionalised due to court/regulatory order

Keywords: tccu advanced tccu metastatic tccu transitional cell carcinoma of the urothelium advanced transitional cell carcinoma of the urothelium metastatic transitional cell carcinoma of the urothelium cisplatinum failure vinflunine javlor daily routine concomitant antiemetic treatment concomitant antiobstipative treatment concomitant antiobstipative diet patient compliance quality of life non-interventional study germany advanced / metastatic tccu after cisplatinum-failure
serum biomarker he4 during ivf treatment

Conditions: IVF Treatment; Human Epididymal Secretory Protein E4

Summary: human epididymal secretory protein 4 (he4) is a new biomarker for ovarian cancer. the effect of ivf stimulation will be evaluated in order to see whether severe hormonal changes in the gonadotrophin and steroid status affect the serum levels of this marker. findings will be compared to serum concentrations of ca-125, which is currently the most often used marker for ovarian cancer. the intention is to determine the serum concentration of he4 and ca-125 in serial samples in 20 women undergoing ivf stimulation. samples will be taken following gnrh agonist suppression, 2-3 times during fsh stimulation, at ovum pick up and two weeks following embryo transfer at the time of the hcg-test. the ovarian follicle count and the serum estradiol concentrations are recorded throughout the treatment. the serum biomarker he4 is expected to ba a stable marker, which does not respond significantly to hormonal stimulation.


Eligibility criteria:
inclusion criteria: * infertility treated by ivf exclusion criteria: * pelvic tumor * overweight (bmi over 35)

Keywords: he4 ivf biomarker ovarian cancer infertility
hydroxyurea for children and young adults with sickle cell disease and pulmonary hypertension

Conditions: Sickle Cell Disease; Pulmonary Hypertension

Summary: the goal of this study is to test the hypothesis that hydroxyurea is effective for the specific treatment of secondary pulmonary hypertension found on screening in children and young adults with sickle cell disease.

increasing evidence suggests that pulmonary hypertension, defined by an elevated tricuspid regurgitant jet velocity (trjv) on echocardiogram, is a major cause of morbidity and mortality in adults with sickle cell disease (scd). however, both the prevalence and optimal treatment of pulmonary hypertension in children and young adults with scd are unknown. we hypothesize that short term therapy with hydroxyurea will decrease trjv in children and young adults with pulmonary hypertension found on screening. patients eligible for treatment will have had evidence of pulmonary hypertension on at least 2 screening echocardiograms. baseline laboratory tests will be obtained and other causes of secondary pulmonary hypertension will be excluded prior to initiation of treatment. patients will be treated with hydroxyurea according to a standard dose escalation schedule for a total of 12 months. a clinic visit will be required every 2 months and standard screening for toxicity will be performed monthly. there will be an interim analysis of the primary outcome at 6 months following therapy.

Eligibility criteria:
inclusion criteria: * age between 10 and 25 years old * sickle cell disease with hemoglobin ss, sc or s-b\^0 thalassemia confirmed on hemoglobin electrophoresis * tricuspid regurgitant jet velocity (trjv) equal to or greater than 2.5 m/sec on 2 baseline doppler echocardiograms at least 3 months apart exclusion criteria: * patients already being treated with hydroxyurea * patients on a chronic transfusion protocol * patients with evidence of hepatic (alanine aminotransferase \[alt\] equal to or greater than 2 sd above normal) or renal dysfunction (creatinine \[cr\] equal to or greater than 2 sd above normal) * patients who are pregnant * patients with documented causes of severe pulmonary hypertension other than from scd

Keywords: sickle cell disease pulmonary hypertension
establishment of mri model for ptrg in rectal cancer with establishment of

Conditions: Rectal Cancer

Summary: this study proposeto integrate a variety of imaging quantitative indicators to establish a new mri-based tumor response regression(mrtrg) classification method. the accuracy of the established mrtrg classification method according pathology trg(ptrg) will be tested. the ability of the established mrtrg classification method to predict prognosis will also be tested.

the study included two part: one is a retrospective single-center cohort for analyzing quantitative mri factors associated with ptrg, from which a new mri-based tumor response regression(mrtrg) classification method will be established. the other is a prospective multi-center cohort for testing the accuracy of the established mrtrg classification according to ptrg; and also for validating the established mrtrg classification associated with survival.

Eligibility criteria:
inclusion criteria: * biopsy-proved primary rectal cancer * baseline mri confirmed larc (ct3 and/or cn+) * scheduled to take neoadjuvant therapy * receive baseline and preoperative pelvic mri * receive tme surgery after nat * have routine follow-up after the operation exclusion criteria: * history of malignancy or multiple primary cancers * receive surgery directly without nat * don't receive tme surgery * don't complete nat * simultaneous distant metastasis at the baseline diagnosis * lack of baseline or preoperative pelvic mri * incomplete or unavailable pathological information * lost to follow-up within three months after surgery (lost since the first follow-up visit)

Keywords: rectal cancer neoadjuvant therapy
clinical and molecular study of charge syndrom

Conditions: Development Abnormalies; Inclusion on Clinical Criteria of the Syndrome

Summary: 1. clinical description of a french cohort of patients with charge syndrome. 2. search any phenotype-genotype correlation in typical, atypical or incomplete form of the syndrome 3. using next generation sequencing, try to identify other genes involved in this syndrome, as the chd7 gene is involved in only 40-60% of cases


Eligibility criteria:
inclusion criteria: clinical criteria major criteria: * ocular coloboma * chonamal atresia and/or cleft palate * semi-circularcanals hypoplasia minor criteria: * cranial nerves * hypothalamic-pituitary deficiency * internal or external ear malformation * cardiac, esophageal malformations * intellectual deficiency diagnosis criteria: * typical charge: 3 major criteria or 2 major + 2 minor * partial charge: 2 major + 1 minor * atypical charge: 2 major without minor or 1 major + 2 minor exclusion criteria: * absent consentment for genetic analysis
zinc supplementation for young infants with clinical severe infection in tanzania

Conditions: Neonatal Infection

Summary: bacterial infections among young infants, including sepsis, meningitis, and pneumonia, continue to cause a substantial number of deaths globally. zinc supplementation in combination with standard antibiotic therapy may represent a new intervention to reduce mortality and improve treatment outcomes for young infants with clinical severe infection. the investigators will conduct a randomized, double-blind, placebo-controlled trial of zinc supplementation among young infants 0-59 days with severe clinical infection. the trial will enroll 3,250 tanzanian infants hospitalized with clinical severe infection as defined by who integrated management of childhood illness (imci) guidelines. enrolled infants will receive standard clinical management including antibiotics and will be randomized to receive either a 14-day course of twice-daily 5 mg elemental zinc (10 mg per day) or a matching placebo regimen.


Eligibility criteria:
inclusion criteria: * young infants aged 0-59 days * diagnosis of clinical severe infection (csi) * ability to feed enterally * intend to stay in the study area for 90 days * provided informed consent exclusion criteria: * prior use of zinc supplements during the current illness * receipt of antibiotics for \>24 hours before enrollment * diarrhea at enrollment * signs suggestive of serious illness/condition that is not clinical severe infection * previously enrolled in the trial * enrolled in other research study