Kornimate/medical-research-clean huggingface dataset:
the role of indocyanine green angiography fluorescence on intestinal resections in pediatric surgery.

Conditions: Intestinal Atresia; Necrotizing Enterocolitis; Hirschsprung Disease; Gastroschisis; Intestinal Obstruction; Incarcerated Hernia; Intussusception; Malrotation; Volvulus; Meconium Ileus; Intestinal Perforation; Trauma

Summary: background: intestinal resections are commonly performed in the pediatric population. perfusion of the bowel is one of the most important factors determining the viability of an intestinal anastomosis. up to date, no ideal method to assess intestinal perfusion has proven its superiority. objectives: primary: the aim of this study is to establish the feasibility and impact of the use of indocyanine green technology on intestinal resection margins during elective and emergency pediatric surgeries. secondary: the secondary outcomes of interest include collection of adverse events and difficulties encountered with the use of the indocyanine green (icg) technology. postoperative surgical complications will also be recorded. study design: an open observational clinical study will be performed by using a clinical drug (indocyanine green) and medical device (spy fluorescence imaging) to assess intraoperatively intestinal perfusion in a specific pediatric population.


Eligibility criteria:
inclusion criteria: * patients \< 16 years old * admitted between september 2019 and september 2020 * patients undergoing a surgery at chusj * any diagnosis requiring intra-abdominal intestinal resection (including stoma reversal) * written informed consent form from the parents or legal guardian exclusion criteria: * patients \> 16 years old * patients with known allergy or sensitivity to iodine * patients with known kidney or liver failure * patients with known severe cardiac or pulmonary diseases * informed consent unobtained or impossible due to refusal of parents, language barrier, or diminished comprehension

Keywords: spy imaging indocyanine green pediatric surgery icg intestinal resections intestinal perfusion
epidemiology of pain in the delivery room

Conditions: New Born Child Pain

Summary: the nociceptif system of the newborn child is functional from 22 to 23 weeks of pregnancy. during the delivery the baby is exposed to multiple exterior factors and he is capable to memorize the pain .recent epidemiologic studies showed that the coverage of pain was insuffcient and also an increase of analgesic means. normally the pain coverage have to be managed and group every painful gesture. in fact all these recommandations are not followed by medical team. the aim of the study is to evaluate the prevalence of this type of pain as to set up an adequate coverage.


Eligibility criteria:
inclusion criteria: * newborn child been born after 24 weeks amenorrheas undergoing a painful gesture in delivery room exclusion criteria: * newborn child been born in palliative care * non francophone parents
pilot of a trial enrollment diversity dashboard

Conditions: Leukemia; Acute Leukemia

Summary: the goal of this study is to test the feasibility of a data visualization tool called the trial enrollment diversity dashboard (tedd) to ensure participant diversity in acute leukemia trial enrollment.

this study is about testing a tool called the trial enrollment diversity dashboard (tedd) to see if it can help increase diversity in cancer clinical trials, specifically for leukemia. clinical trials are important for developing new cancer treatments, but not all groups are equally represented in these trials. this can lead to treatments that may not work as well for everyone. the tedd tool is designed to give medical professionals feedback on how diverse their patient enrollments are clinical trials. by using this tool, medical professionals can see if they are enrolling a diverse group of patients and make changes if needed. the study will involve a small group of medical professionals who treat leukemia patients. they will use the tedd tool and provide feedback on its usability and effectiveness. study procedures include completion of surveys and usage of the tedd intervention dashboard. it is expected that about 12 medical professionals will take part in this research study. participation in this research study is expected to last about 14 months. the national cancer institute is providing funding for this research study.

Eligibility criteria:
inclusion criteria medical professionals: * physician, nurse practitioner, or physician assistant -≥10% clinical effort (or one ½ day of clinic per week for those working \<1 fte) * treats adult patients with leukemia or related diseases at the study sites * ability to understand and willingness to provide informed consent * age 18 or older inclusion criteria participant population: * age ≥18 years old * diagnosis of leukemia, lymphoma, myeloma, or related diseases * seen by a physician for this diagnosis at one of the study sites exclusion criteria medical professionals: -listed member of the research team exclusion criteria participant population: -participants without the diagnoses of interest listed above, participants not seen at the study sites.

Keywords: leukemia acute leukemia clinical trial diversity
respiratory muscle training in l-onset pompe disease (lopd)

Conditions: Glycogen Storage Disease Type II

Summary: this study is being done to test the effects of respiratory muscle training (rmt) in patients with late-onset pompe disease (lopd) who have weakness of their breathing muscles. the results of this study will help design future research studies about rmt in lopd. the goals of this study are to decide if sham-rmt is a useful control condition for rmt and to choose the best ways to measure the health benefits of rmt in lopd.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * diagnosis of lopd * on enzyme replacement therapy for ≥ 26 weeks at pretest * able to follow directions for study participation * able to complete a home-based rmt regimen exclusion criteria: * neurodegenerative conditions (e.g. stroke, dementia) or other serious neurologic condition that would prevent meaningful study participation as determined at the discretion of the principle investigator * inability to give legally effective consent * inability to read and understand english
phase ii study of neoadjuvant dostarlimab in patients with untreated t3-4n0-2 or stage iii pmmr/mss resectable colon cancer

Conditions: Colon Cancer Stage III

Summary: dostarlimab belongs to a class of drugs called pd-1 inhibitors that use your own immune system to treat cancer (immunotherapy). it is designed to stop cancer from growing by helping your immune system recognize and fight the cancer. this investigational medicinal product (imp) has been approved by the belgian authorities, but not for the treatment of colon cancer. it is known that a small number of patients with pmmr/mss colon cancer may have significant response to medication of this type (immunotherapy) depending on each person's biology. trial intervention for all patients will be neo-adjuvant dostarlimab 500 mg iv, given alone by intravenous infusion. two administrations of dostarlimab are foreseen, at three weeks interval, before surgery for your colon cancer. it has not yet been proven that this treatment can cure, improve or stabilise your disease or condition. the study aims to investigate specific molecular changes in tumour and blood after dostarlimab monotherapy administered and before surgery which could be associated with improved response to conventional treatment in some patients. if you decide to participate, as the duration of treatment with dostarlimab is 6 weeks, surgery may be slightly delayed compared to patients that are not treated with dostarlimab and go directly for surgery. it remains uncertain if this is beneficial in your personal situation but some patients might experience significant response. the risks have been carefully assessed and the potential benefits for some patients are considered important and justify undertaking the treatment. subsequent therapy after surgery remains at the discretion of the treating physician. the duration of a patient on trial will last up to 4 months from the first dose of dostarlimab and afterwards 2 years of follow up is applicable.


Eligibility criteria:
inclusion criteria: * at least 18 years of age and capable of giving informed consent * primary adenocarcinoma colon cancer than can be removed surgically, staged ct3-4, cn0-2, cm0 or stage iii * tumour expresses an mmr proficient/microsatellite stable called mss * tissue samples from tumour and colon mucosa available for molecular analyses * capable of receiving immunotherapy * adequate general health status and organ function (blood tests) exclusion criteria: * no prior cancer treatment * not pregnant and using effective contraception if applicable

Keywords: colon cancer neoadjuvant pmmr/mss resectable
pericapsular nerve group (peng) block for congenital hip dislocation surgery

Conditions: Congenital Hip Dysplasia

Summary: developmental dysplasia of the hip (ddh) is one of the major disorder of the pediatric population with an incidence of 3 to 5 per 1000 children. open surgical reduction of congenital hip dislocation (chd) is typically performed after an ineffective closed reduction or older than 18 months. multiple femoral or pelvic osteotomies and tenotomies are performed during this surgical treatment and cause severe postoperative pain. pericapsular nerve group (peng) block has been recently recommended for use as postoperative analgesia in hip surgeries. it is a new regional anesthesia method based on blocking the articular branches of femoral nerve (fn) and accessory obturator nerve (aon) in the region between the anterior inferior iliac spine (aiis) and iliopubic eminence (ipe).the aim of this study was to evaluate the analgesic effect of ultrasound guided pediatric pericapsular nerve group (peng) block in pediatric patients undergoing chd surgery.


Eligibility criteria:
inclusion criteria: -american society of anesthesiologist's physiologic state i-ii patients undergoing hip dislocation surgery exclusion criteria: * chronic pain * bleeding disorders * renal or hepatic insufficiency * patients on chronic non-steroidal anti-inflammatory medications * emergency cases * incomplete patient forms * infection of the skin at the site of needle puncture area * patients with known allergies to any of the study drugs * american society of anesthesiologist's iii-iv
effects of deep regional hyperthermia in patients with anal carcinoma treated by standard radiochemotherapy

Conditions: Anal Carcinoma

Summary: randomized study to investigate the efficacy of deep regional hyperthermia in patients with anal carcinoma treated by standard radiochemotherapy with mmc and 5-fu.

pat. with anal carcinoma and treated with standard radiochemotherapy with mitomycin c and 5-fu will in the experimental arm receive deep regional hyperthermia (6x).

Eligibility criteria:
inclusion criteria: * histologically proven anal squamous cell carcinoma (scc) (who 2004), including anal canal carcinoma (uicc 2002) and anal margin carcinoma (uicc 2002) * all stages except t1 n0 m0 after local excision (uicc 2002) * age ≥ 18 years * ecog status 0-1 * patients that have understand protocol and signed informed consent form * sufficient bone marrow function: wbc ≥ 3,0 x 10\^9/l, platelets ≥ 100 x 10\^9/l, hemoglobin ≥ 10 g/dl * sufficient liver function: bilirubin \< 1,5 mg/dl, sgot, sgpt, alkaline phosphatase, ggt less than 3 times upper limit of normal exclusion criteria: * stage t1 n0 m0 after local excision (uicc 2002) * uncontrolled, severe cardiac dysfunction (nyha iii/iv) * pre-existing uncontrolled cardiac disease, signs of cardiac failure, or rhythm disturbances requiring therapy * myocardial infarction within the past 12 months * congestive heart failure * complete bundle branch block * new york heart association (nyha) class iii or iv heart disease * chronic inflammatory disease of the intestine * active intractable or uncontrolled infection * chronic diarrhea ( \> nci ctc-grad 1) * acute thrombosis * collagen vascular disease * cardiac pacemaker * hiv-infection; patients with hepatitis a or b virus infection, with hpv infection or patients receiving immune suppressive treatment can be included * devices that preclude deep regional hyperthermia (endoprosthesis, stent in vascular system, acute thrombosis) * any metal implants (with exception of non-clustered marker clips) * conditions that preclude the application of fractionated pelvic radiotherapy * conditions that preclude regular follow-up * pregnant or breast feeding women * prior pelvic radiotherapy * prior chemotherapy * drug addiction * on-treatment participation on other trials * prior or concurrent malignancy or leucemia (≤ 5 years prior to enrolment in study) except anal cancer or non-melanoma skin cancer or cervical carcinoma figo stage 0-1 if the patient is continuously disease-free * the presence of increased radiation sensitivity, for example ataxia teleangiectatica, or similar * psychological, familial, sociological, or geographical condition that would preclude study compliance

Keywords: anal carcinoma hyperthermia radiotherapy chemotherapy radiochemotherapy
an investigation of different type single limb exercise training effects in copd

Conditions: Exercise

Summary: copd presents not only respiratory symtoms but also vascular or muscle dysfunction. exercise limitation is observed in copd. especially, decreased exercise performance related to vascular and fatique in quadriceps muscle. exercise training is important for aerobic performance increasing. generally results show exercise training with both lower limb. increaed arterial stiffness and fatigue are observed in copd. one leg exercise training result is not enough to highlight these parameters. three types single leg exercise intervantion will be applied. exercise capacity, muscle strength, lung function, electromyography, lactate and quality of life will be measured.

three types single leg exercise intervantion will applied to copd patients that devided three groups. one leg continuous exercise training will be aplied to one group. one leg hiit exercise training will be aplied to other group. one leg resistance exercise training will be aplied to the last group. exercise capacity and muscle strength are assesed. lung function is measured. electormyography is recorded. lactate and quality of life are measured.

Eligibility criteria:
inclusion criteria: * copd patients that applied to physiotherapy * cooperation for tests * without severe ortopedical and neurological disease * without severe cardiovascular disease * to volunteer for the study. exclusion criteria: * have an acute exacerbation or having exacerbation at last month * hypoxemia (pao2\<55mmhg) * no cooperated to test without volunteer to study having ortophedical and neurological diesase that affecting of tests severe cardiovascular disease

Keywords: chronic obstructive pulmonary disease single limb exercise resistance training continous exercise training high intensity exercise training
rox index in acute respiratory failure

Conditions: Rox Index

Summary: evaluation of rox index among icu patients to evaluate the success of non invasive ventilation or the need for intubation


Eligibility criteria:
inclusion criteria: * participants admitted to ricu with type i and type ii respiratory failure requiring niv support with one or more of the following : 1. pao2/fio2 less than or equal to 300 mmhg despite supplying oxygen at a flow rate ≥ to 10 l/min for ≥ 15 min 2. patients requiring ventilatory support due to increased respiratory rate ≥ 25 breaths/min or using accessory muscles of respiration exclusion criteria: * 1. absolute indication for intubation like coma, hemodynamic instability, or life-threatening arrhythmia. 2. contraindication to niv like untreated pneumothorax, pneumothorax with air leak, widespread facial burn or trauma, tracheotomy,or active upper gastrointestinal bleeding. 3. resusal to participate in the study
cast immobilization for non-displaced scaphoid fractures

Conditions: Non-displaced Scaphoid Fractures

Summary: this trial is trying to understand if immobilization of the thumb after a non-displaced scaphoid fracture affects recovery. the standard of care overseas is a cast that allows for free movement of the thumb, and in the united states it is a cast that immobilizes the thumb. this study is attempting to understand if there is a difference.


Eligibility criteria:
inclusion criteria: 1. 18 years or older 2. isolated fracture of the scaphoid 3. no displacement of the scaphoid fracture on ct scan exclusion criteria: 1. associated ipsilateral ligament injury or fracture 2. pregnant patient
detailed pain pattern after laparoscopic inguinal hernia repair

Conditions: Inguinal Hernia; Femoral Hernia

Summary: pain after laparoscopic groin hernia repair consist of different pain components (overall pain, shoulder pain, incisional pain and visceral pain). thus it is important to find out which of these pain components that is most severe, so intervention can be targeted.

details about the components of early pain after laparoscopic groin hernia repair are lacking. a description of each component (overall pain, shoulder pain,incisional pain and visceral pain) is needed, so intervention against the different pain components can be targeted. patients fill out questionnaires about pain before operation and day 0-3 after operation.

Eligibility criteria:
inclusion criteria: * men * 18-69 years * uni- or bilateral hernia * asa i-ii * danish speaking exclusion criteria: * bad compliance * acute operation * daily intake of opioids

Keywords: pain pattern overall pain incisional pain shoulder pain visceral pain
nutritional requirements for vitamin d in pregnant women

Conditions: Vitamin D Deficiency

Summary: randomised, placebo-controlled dose-response intervention study with vitamin d3 in pregnant women.

this is a three-arm, parallel, double-blind, placebo-controlled dose-response intervention study with vitamin d3. women will be recruited prior to 18 weeks of gestation and randomised to receive placebo, 10 or 20 mcg/d of vitamin d3 from baseline visit in their first trimester until delivery. blood samples will be collected at baseline, midpoint and endpoint of the trial, at 10 week intervals, and from the umbilical cord at delivery. a 25-hydroxyvitamin d concentration of 30 nmol/l will be used to denote vitamin d deficiency. information on maternal anthropometry, diet, lifestyle, sun exposure, blood pressure, ipth and serum total calcium will also be reported.

Eligibility criteria:
inclusion criteria: * adult (\>18 years) * no more than 18 weeks gestation * in good general health * low risk pregnancy * not consuming \>10 mcg/d vitamin d from supplements exclusion criteria: * current smokers * diagnosed hypertension * known high-risk pregnancy * diagnosed medical illness including diabetes mellitus (types 1 \& 2), chronic kidney disease or gastro-intestinal diseases or any illness known to interfere with calcium metabolism (e.g. sarcoidosis). * consumption of medications known to interfere with vitamin d metabolism * consumption of vitamin d (≥ 10 µg/day) or calcium (≥ 650 mg/d) supplements prior to randomization

Keywords: vitamin d cholecalciferol dose-response randomized controlled trial pregnancy cord blood serum 25-hydroxyvitamin d vitamin d deficiency nutrition dietary intervention study
hypoxia pre-conditioning and mountain sport

Conditions: Coronary Artery Disease (CAD)

Summary: mountain sport activities as for example hiking or skiing may involve the risk of adverse health events especially in older people not accustomed to the specific mountain sport at altitude or people with pre-existing health issues. increased activation of the sympathetic nervous system and abrupt changes in heart rate and blood pressure are thought to trigger these adverse effects. preventive measures include regular physical activity (i.e. training) and adequate medical treatment. hypoxia pre-adaptation (e.g., pre-adapt one night at moderate altitude) and pre-conditioning (e.g., intermittent hypoxia (ih) training), which was shown to lead to some favorable sympathetic nervous system, ventilatory and metabolic adaptations and additionally exerts anti-inflammatory action, could be hypothesized of being a further preventive measure. the aim of this research project is to investigate whether intermittent hypoxia pre-conditioning or sleeping one night at altitude (i.e., current recommendation before practicing mountain leisure sports in the elderly) is able to increase oxygen saturation during passive hypoxia exposure and during simulated hiking and skiing at altitude. additionally, it is aimed to investigate whether such procedure reduces the physiological responses (i.e., heart rate, its variability and blood pressure (including baroreflex sensitivity) responses as well as metabolic, ventilatory, inflammatory and redox responses) during these activities.


Eligibility criteria:
inclusion criteria: * participants will include normally physically active males and females (age 50-70 years; new york heart association (nyha) class i and ii) with or without prior myocardial infarction, living \<600 m. exclusion criteria: * persons with cad will be excluded if they will not be able to perform light to moderate exercise, or had recent myocardial infarction and/or revascularisation (\ 180/100 mm hg), pulmonary hypertension or any other severe systemic non-cardiac disease. exclusion criteria will additionally include regular smoking of more than five cigarettes per day, regular drug intake, habitual residence \> 600 m and one or more overnight stay at \> 1000 m during the previous 4 weeks.