Kornimate/medical-research-clean huggingface dataset:
family engagement strategy for coordinated specialty care

Conditions: Family Members; Implementation

Summary: family members/support persons' engagement in mental health services has been linked to reduced burden and stress and improves engagement and outcomes in individuals in the early stages of psychosis. the goal of fames is to address low family member/support person engagement in services. fames will also address disparities in coordinated specialty care (csc) by using a culturally responsive family engagement strategy to be delivered by family peers.

the overall goal of this mixed-methods, clustered stepped-wedged designed study is to examine the effectiveness of a family peer implemented in coordinated specialty care programs at engaging family members in services. the use of a family peer is anticipated to increase family member participant's feelings of connectedness, self-efficacy, and motivation which will in turn improve family member participants engagement in scheduled coordinated specialty care services such as family psychoeducation. recruitment will consist of dyads compromised of a family member support person and a corresponding individual receiving coordinated specialty care services. recruitment will occur over two waves, the attention control condition (acc) and the fames condition. the acc will last for 18 months and will recruit 225 participant dyads during which time family member participants will be contacted weekly for 12 weeks where they will be provided with positively framed messaging, educational materials around psychosis, tips for addressing relevant concerns in areas such as communication and de-escalation, and a list of community-based and online resources and events. the fames condition will last for 30 months and will recruit 225 participant dyads during which time family member participants will receive a modified cultural formulation interview, brief check-ins, psychoeducation, and will have access to an online community. recruitment will take place at nine coordinated specialty care programs across four states (washington, oregon, tennessee, and new mexico) which have been randomized to a clustered stepped wedge program design.

Eligibility criteria:
inclusion criteria: * family member/support person of an individual enrolled in coordinated specialty care services for equal to or less than 6 months. * 18 years of age or older. * during the active implementation period (fames) did not participate in the attention control condition. exclusion criteria: * if they do not understand the consent process. * if they do not speak and/or understand english or spanish.

Keywords: early psychosis family peer engagement
vein vs arterial grafts for coronary artery bypass grafting surgery

Conditions: Angina Pectoris

Summary: the investigators have developed a novel technique for saphenous vein graft harvesting for coronary artery bypass grafting (cabg) where the graft is harvested with a pedicle of surrounding tissue. a randomized trial has shown a significantly higher patency rate for vein grafts harvested with this new methode compared to conventional harvesting technique 8.5 years after surgery (90 vs 76 %). in 2004 the investigators started a prospective randomized trial comparing patency between vein grafts harvested with surrounding tissue and radial artery grafts. the result showed that vein grafts harvested with surrounding tissue had a significantly higher patency rate compared to radial artery grafts 3 years after surgery (98 vs 84 %). the present study is a long-term follow-up (8 years) of the patients included in the second randomized trial. the hypothesis is that vein grafts harvested with surrounding tissue have a significantly higher patency rate compared to radial artery grafts 8 years after surgery.


Eligibility criteria:
inclusion criteria: * three vessel coronary artery disease exclusion criteria: * 65 years or older * elevated creatinine * raynauds disease * vein stripping

Keywords: cabg saphenous vein radial artery
comparative effects of aerobic exercises and progressive muscle relaxation exercises on pain and quality of life

Conditions: Pain Syndrome; Anxiety

Summary: premenstrual syndrome is the clinical condition in which reproductive age females suffer from emotional and physical symptoms not related to any disease, starting usually 5 days before the menstrual cycle for 3 consecutive cycles.

premenstrual syndrome is the clinical condition in which reproductive age females suffer from emotional and physical symptoms not related to any disease, starting usually five days before the menstrual cycle for three consecutive cycles. as menstrual cycle starts in females these symptoms vanish on 4th day of menstruation. around 10% to 53% of female adults suffer from this condition. this condition limits activities of daily life and adversely effects the quality of life therefore, the administration of proper medical intervention is very important. aerobic exercises and progressive muscle relaxation exercises have been effective in the treatment of premenstrual syndrome previously in a few studies. however, these two interventions have never been compared to test their effects on pain, and functional performance.

Eligibility criteria:
inclusion criteria: * age between 18 to 40 years * females in their last week of the luteal phase (1 week before menstruation) * females with regular menstrual with equal intervals between 21 and 35 days * females with a score of 133 and above after being screened with premenstrual syndrome scale * females suffering from pms for at least the past six months exclusion criteria: * females with the irregular menstrual cycle * pregnant females * menstruating females or females in the follicular or ovulatory phase * history of physical exercise in the past three months before the beginning of the study * females suffering from other gynecological issues such as endometriosis, pcos, uterine or cervical cancer
partners hf: program to access and review trending information and evaluate correlation to symptoms in patients with heart failure

Conditions: Heart Failure, Congestive

Summary: the purpose of this study is to determine the value of diagnostic data obtained from medtronic implantable cardioverter defibrillators (icds) with cardiac resynchronization therapy (crt) to evaluate cardiovascular and heart failure related adverse events and health care utilization.


Eligibility criteria:
inclusion criteria: * patients who meet the icd indications * patients with class iii or iv heart failure. * patients receiving or who received a medtronic crt icd within the previous 3 months. * patient must sign and date informed consent, and be 18 years of age or greater. * patient must be available for follow up visits, and be willing and able to comply with study protocol. exclusion criteria: * patient with acute myocardial infarction (mi), coronary artery bypass graft surgery (cabg) or percutaneous coronary angioplasty (ptca)/stent within the last month. * patient with a mechanical right heart valve. * patient with chronic (permanent) atrial arrhythmias. * patient with life expectancy of less than 12 months. * patient with status post heart transplant * patient undergoing kidney dialysis * patients enrolled in a concurrent study that may confound the results of the study.

Keywords: heart failure, congestive implantable cardioverter-defibrillators
noninvasive real-time intracardiac pressure measurements using subharmonic ultrasound

Conditions: Cardiac Catheterization; Blood Pressure; Heart Ventricles; Echocardiography; Heart Failure

Summary: this study will use contrast echocardiography to assess the accuracy of a new non-invasive imaging method for subharmonic aided pressure estimation (shape) compared to simultaneously acquired intra-cardiac pressures measured invasively during cardiac catheterization. this study is designed to verify that contrast echocardiography using the shape method, already proven in a canine model and tested in a human pilot study can be used as a surrogate for cardiac catheterization with sufficient accuracy to allow clinical applicability in humans.


Eligibility criteria:
inclusion criteria: * be scheduled for cardiac catheterization procedure. * be at least 18 years of age. * be medically stable. * if a female of child-bearing potential, must have a negative pregnancy test. * be conscious and able to comply with study procedures. * have signed informed consent to participate in the study. exclusion criteria: * clinically unstable patients, e.g., those who are clinically in decompensated heart failure or having active chest pain or presenting for admission with an unstable anginal syndrome * patients in whom introduction of a catheter into the left ventricle is contraindicated or would potentially be dangerous, e.g., patients with active ventricular arrhythmias or with significant aortic valve stenosis where crossing the aortic valve may be difficult and not clinically necessary * females who are pregnant or nursing. * patients not scheduled for cardiac catheterization procedure. * patients who have received an investigational drug in the 30 days before, or will receive one within 72 h after, study drug administration. * patients currently on chemotherapy or with other primary cancers requiring treatment. * patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable. * patients with a history of anaphylactic allergy to eggs or egg products, manifested by one or more of the following symptoms: generalised urticaria, difficulty in breathing, swelling of the mouth and throat, hypotension, or shock. (subjects with nonanaphylactic allergies to eggs or egg products may be enrolled in the study, but must be watched carefully for 1 h following the administration of sonazoid). * patients with congenital heart defects. * patients with severe emphysema, pulmonary vasculitis, or a history of pulmonary emboli. * patients with respiratory distress syndrome or a contraindication to pharmacological vasodilator stress agents. * patients with thrombosis within the hepatic, portal, or mesenteric veins.

Keywords: pressure measurements blood pressure contrast echocardiography ventricular pressures catheterization
electrical impedance tomography: collapse in dependent areas as a predictor of response to prone position ventilation in covid-19 acute respiratory distress syndrome

Conditions: SARS-CoV Infection; Acute Respiratory Distress Syndrome

Summary: there are several clinical presentations of sars-cov-2 infection. among the severe forms, pulmonary involvement with respiratory failure is common. although severe lung involvement with sars-cov-2 meets the berlin criteria for acute respiratory distress syndrome (ards), it differs from classic ards in that compliance (reflecting distensibility of the lung parenchyma) is frequently preserved. if the interest of electrical impedance tomography has been demonstrated in classical ards, this is not the case in ards with covid-19. however, the use of this technique in this particular patient population would make it possible to distinguish patients with severe hypoxemia linked to derecruitment from those without derecruitment, in whom hypoxemia is more likely to be linked to the loss of hypoxic vasoconstriction.


Eligibility criteria:
inclusion criteria: * patients admitted to the intensive care unit for sars-cov-2 ards * under controlled invasive ventilation for less than 7 days exclusion criteria: * pneumothorax * deformation of the rib cage * contraindication to electrical impedance tomography * pregnant or breastfeeding woman
kabat rehabilitation versus mime therapy on facial disability and synkinesis in patients of bell's palsy

Conditions: Bell Palsy

Summary: bell's palsy, also called idiopathic facial paralysis, is a common cause of unilateral facial paralysis. it is one of the most common neurological disorders of the cranial nerves.

bell's palsy is an alarming condition of rapid onset, which paralyzes half of the facial muscles. kabat rehabilitation is a manual resistance technique that promotes a basic pattern of movement through facilitation, inhibition, and resistance of a group of muscles. it increases the functioning and power of facial muscles while mime therapy results in immediate improvement of function and integrity of facial muscles. it also mitigates synkinesis in bell's palsy. both techniques are easy to apply. they are clinically important techniques that are easily understood by patients.

Eligibility criteria:
inclusion criteria: 1. age group 25-50 years. 2. both male and female. 3. unilateral bell's paralysis. 4. not congenital in origin. 5. sub-acute and chronic cases. exclusion criteria: 1. other neurological deficits include epilepsy and alzheimer's disease. 2. traumatic onset. 3. surgical reconstruction (nerve or muscle reconstruction). 4. mental and psychological disorders i.e., schizophrenia, bipolar disorders. 5. skin diseases (eczema, urticarial) as electrical stimulation may affect the results. 6. any contraindications for massage like sunburn, bruising, or cuts.

Keywords: bell palsy kabat rehabilitation mime therapy
a multicenter, open label trial to evaluate pain relief with intravenous followed by oral therapy with parecoxib/valdecoxib 40 mg/day for treatment of post-laparoscopic surgery pain

Conditions: Pain, Post Surgical

Summary: the objectives of this study were to assess the analgesic efficacy and safety of parecoxib/valdecoxib on post-laparoscopic surgery analgesia.

this study a3471107 was terminated on february 4th, 2005 due to enrollment difficulties, problems related to need for rescue medication, and perceptions about cardiovascular risk potentially associated with all nsaids.

Eligibility criteria:
inclusion criteria: * patients who had undergone laparoscopic surgery * patients in need of post-surgical analgesia exclusion criteria: * patients with an unexpected surgical complication which, in the investigator's opinion, placed the patient at significantly higher risk for post-surgical complication(s), or for non-routine post-operative care requirements * patients who took any nonsteroidal anti-inflammatory drug or any analgesic within 48 hours prior to surgery

Keywords: laparoscopy
escap-2020-cphg: treatment strategies follow-up implemented during the first three years following primary lung cancer (plc) diagnosed in kbp-2020-cphg cohort patients

Conditions: Lung Cancer

Summary: the prognosis for primary lung cancer (plc) is very limited. in france, patients diagnosed for plc in 2010 and followed in respiratory medicine or oncology department of a general hospital centre had a 5-year survival rate of 12.7% (vs 10% in 2000). over the last ten years, substantial improvements have been made both in terms of diagnostic (immunohistochemistry and molecular biology) and therapeutic. new treatments have been marketed and are now available in clinic. new therapeutical strategies have been launched and have proved their efficacy in clinical studies or meta-analyses, generally increasing the survival rate of patients by a few months. however, little information still exists on the use and effectiveness of these molecules in clinical practice. the cphg proposes to complete the information collected during kpb-2020-cphg study by the escap-2020-cphg study that is a follow-up of therapeutical strategies over the first 3 years of treatment. this study should improve knowledge of the plc treatment management in general hospital centres.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * primary lung cancer histologically (or cytologically or presence of a mutation on liquid biopsy with compatible imaging) proven between january 1st and december 31st, 2020\* * follow-up by a lung specialist at a general hospital * oral informed consent \* date of collected sample exclusion criteria: * age \< 18 years * secondary lung cancer * recurrence of same histological type plc- left to the investigator discretion according to the clinic and the imagery * previous enrolment in the study * freedom deprived patient following a legal or administrative decision * patient unable to give his(her) consent
the impact of removal of exercise on glycemic control and vascular health in older active adults

Conditions: Glucose Intolerance; Exercise; Vascular Function

Summary: the purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. glycemic control is the blood glucose response following the consumption of a meal. it is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. endothelial function has been shown to be improved by chronic or acute increases in physical activity. both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. in this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.


Eligibility criteria:
inclusion criteria: 1. 55 years and older, 18-40 years old 2. healthy, physically active, performing at least 90 min/week of physical activity 3. free of physical limitations that may interfere with alterations in daily physical activity levels exclusion criteria: 1. physician diagnosed hiv, hepatitis, or tuberculosis. 2. body weight change of greater than 5% within the previous 2 months 3. smoking within the previous 2 months. 4. taking medications that alter blood glucose levels
using pharmacogenetics to identify patients with polypharmacy at risk of medication adverse effects

Conditions: Psychiatric Disorder

Summary: the researchers are trying to learn more about how individuals break down and process medications based on their genes. the researchers want to find out whether subjects will have fewer side effects if they take different medications based on their pharmacogenomics profile.

the researchers are trying to learn more about how individuals break down and process medications based on their genes. the researchers are doing this in order to assess the number of potential genotype-based drug interactions and side effects in patients with polypharmacy as well as to assess the number of potential individualized (based on the patient's genotype) drug interactions and side effects in these patients. after completing the oneome genetic testing and relaying those results to the patients care team, the researchers will then assess, at 30 days post-recommendations, whether the medication recommendations to reduce individualized drug interactions and adverse effects were followed, and (2) whether the adverse effects decrease compared to admission. patients will be recruited from the inpatient units listed in the inclusion criteria and, upon admission, each patient will complete a 24 item questionnaire measuring medication side effects, have a review of their medications for potential drug-drug and drug-genotype interactions (classified as low, medium or high risk), and then undergo the buccal swab to collect the dna cells which will then be sent to oneome for analysis. when the results are available, the study investigators will review the medications again for potential drug-drug and drug-genotype interactions and then communicate to the patients clinical team those results and whether medication changes are recommended to minimize the drug-drug and drug-genotype interactions. thirty days after the recommendations are communicated to the patient's clinical team, the patient will be contacted by phone. during this phone call, the following information will be obtained: 1. the patient's current medication list. 2. the patient's 24 item questionnaire measuring medication side effects. 3. the patient's one item self rating of improvement once this phone call is completed, the research team will determine whether the medication recommendations were followed by the patient's clinical team, whether the adverse effects decreased compared to hospital admission, and whether the patient reported improvement.

Eligibility criteria:
inclusion criteria: * ages 18 and older * hospitalized on generose 2e (acute care psychiatry), 3e (medical and geriatric psychiatry), or 3w (mood disorders unit). * a voluntary patient * having 5 or more medications (scheduled or as needed) on their medication list. * ability to give informed consent exclusion criteria: * patient with cognitive impairments such as moderate to severe dementia. * patients who do not communicate in english or cannot comprehend the rating scales used. * patients who have had pharmacogenetics testing performed within the previous 5 years.

Keywords: polypharmacy
efficacy and safety, long-term study of zinc acetate to treat wilson's disease in japan.

Conditions: Wilson's Disease

Summary: the purpose of this long-term study is to determine whether zinc acetate is effective and safe in the treatment of wilson's disease among japanese.

wilson disease is an autosomal recessive disorder with copper metabolism. in japan, the standard treatment is the use of copper chelating agents, such as d-penicillamine and trientine. in this study, we investigate efficacy on zinc acetate in japanese patients with wilson disease.

Eligibility criteria:
inclusion criteria: * wilson's disease(adult, infant, pregnant woman) exclusion criteria: * acute hepatitis * malignant tumor