Kornimate/medical-research-clean huggingface dataset:
a study of ptr-01 in recessive dystrophic epidermolysis bullosa

Conditions: Recessive Dystrophic Epidermolysis Bullosa

Summary: protocol ptr-01-002 is a 3-part phase 2, open-label study of ptr-01. while new patients will be enrolled, priority will be given to patients that satisfactorily completed study ptr-01-001.

protocol ptr-01-002 is a 3-part phase 2, open-label study of ptr-01. while new patients will be enrolled, priority will be given to patients that satisfactorily completed study ptr-01-001. in part 1, patients will receive a dose of 3.0 mg/kg every week for a total of 4 doses. this will be followed by part 2 in which patients will receive a dose of 3.0 mg/kg every other week for a total of 7 doses. in part 3, patients will be followed for 12 weeks. no investigational therapy will be administered during this time. at the end of each dosing period, an efficacy assessment will be performed. safety will be assessed continuously throughout the study. following the end of part 3, patients may be eligible for a potential long-term extension to further refine the dosing regimen, depending upon study drug availability.

Eligibility criteria:
inclusion criteria: patients must meet all of the following criteria to be eligible for study participation in the three month run in period of the study: 1. willing to provide informed consent form, or if 12 to \<18 years of age, legal guardian has provided informed consent form and the minor has signed an assent form acknowledging that they understand and agree to study procedures. 2. has a diagnosis of rdeb based on genetic analysis and consistent with a recessive inheritance pattern. 3. has deficient c7 staining at the dermal-epidermal junction (dej) by if. 4. agrees to use contraception as follows: for women of childbearing potential (wocbp) agrees to use highly effective contraceptive (including abstinence) methods from screening, through the study, and for at least 10 weeks after the last dose of study drug. non-childbearing potential is defined as a female who meets either of the following criteria: age ≥50 years and no menses for at least 1 year or documented hysterectomy, bilateral tubal ligation, or bilateral oophorectomy. for males, agrees to use a condom with any wocbp sexual partner from day 1 of study treatment, through the study, and at least 10 weeks after the last dose of study drug. 5. be willing and able to comply with this protocol. exclusion criteria: patients with any of the following will be excluded from participation in the study: 1. has known systemic hypersensitivity to any of the inactive ingredients in ptr-01. 2. has previously had an anaphylactic reaction to ptr-01. 3. is pregnant or nursing. 4. has received in the last six months any investigational gene therapy product or in the last three months any non-gene therapy investigational products. 5. is anticipated to receive new regimens of antibiotics or other anti-infectives during the trial. 6. has any other medical or personal condition that, in the opinion of the investigator, may potentially compromise the safety or compliance of the patient, or may preclude the patient's

Keywords: rdeb
neurological impacts of artificial sweeteners in the context of diet sodas

Conditions: Obesity

Summary: this study seeks to determine whether artificial sweeteners in the context of diet soda may alter the brain's response to food cues and thus impact appetite.


Eligibility criteria:
inclusion criteria: * men and women who are 18-65 years old, with a bmi \>30kg/m2. exclusion criteria: * unable or unwilling to participate in the study for any reason * metal in the body or other safety concerns which makes patient unable to have an mri * pregnant women will be excluded to protect the fetus against potential effects of a non-medically required mri on fetal development and difficulty of measuring accurate bmi.

Keywords: artificial sweeteners diet soda
efficacy of neuromuscular bandage technique against jones technique after the supraespinatus muscle tendon suture

Conditions: Pain

Summary: the suture of the supraspinatus tendon is a common surgery that requires physical therapy for back pain and functional impairment to such surgery. kinesiotaping technique (kt) is being used to treat myofascial trigger points that appear after surgery and for the treatment of physiotherapy in the supraspinatus muscle and deltoid. to evaluate the effectiveness of kt technique over the technique of jones (straincounterstrain or scs) in patients undergoing suture the tendon of the supraspinatus muscle.

objective: to evaluate the effectiveness of the kt technique against jones (strain-counterstrain or scs) technique in patients with the suture of the tendon of the supraspinatus muscle. design: test clinically controlled, randomized, masking of intervention by double placebo and blind to the subject of the essay and the studio analyst. method: patients with supraspinatus tendon suture are randomly divided into two groups: a group treated with kt (n = 18) and other treated with scs (n = 18). the treatment was applied the 1st, 4th and 8th day of physical therapy session. all patients were evaluated the 1st and the 12th day of the session with the visual analog scale of pain (vas), with the scale of disabilities of the arm, shoulder and hand (dash) to assess the functionality and active direction-finding (rom) to assess travel articulate.

Eligibility criteria:
inclusion criteria: * among patients attending the 1st and 5th week after intervention. * patients with age above 18 years. * patients of both sexes. * patients with a detectable with algometer trigger point in the supraspinatus and / or deltoid . exclusion criteria: * patient with impaired communication . * patients with signs of infection . * patients with previous surgery on the shoulder or shoulder capsulitis submit . * patient scammers cervical herniated discs or brachial neuropathy . * patients with tumor pathology. * patients with fibromyalgia, * pregnant patients. * patients with central pain . * patients conducted simultaneously treatments .

Keywords: trigger points, movement
effect of extracorporeal shock wave therapy (eswt) and phonophoresis treatment in patients with lateral epicondylitis

Conditions: Lateral Epicondylitis; Extracorporeal Shock Wave Therapy; Phonophoresis

Summary: this study aimed to investigate the effects of extracorporeal shock wave therapy and phonophoresis treatment on pain, function, hand grip strength and tendon thickness in ultrasonography in patients with lateral epicondylitis.

lateral epicondylitis (le) is tendinopathy of the forearm extensor muscles, often caused by overuse or repetitive use, forced wrist extension, or direct trauma to the epicondyle. it is the most common cause of lateral elbow pain. although also known as tennis elbow, lateral epicondylitis often develops as a work-related condition and is therefore a significant public health problem. eswt; it involves transmitting high-intensity acoustic pressure waves produced by electrohydraulic, electromagnetic or piezoelectric devices to the target area of the body in a short time through the gel. it has been reported that eswt increases collagen synthesis in tendons, bones and other soft tissues, accelerates vascularization and reduces pain. ultrasound; it has been used for many years in the treatment of musculoskeletal disorders such as tendinitis, epicondylitis, tenosynovitis, bursitis and osteoarthritis. it produces acoustic waves through the conversion of electrical energy. these waves turn into heat as they pass through tissues at different resistance levels. ultrasound is also used to enhance percutaneous absorption of drugs in phonophoresis applications.

Eligibility criteria:
inclusion criteria: * individuals aged 18-65 * those who signed the informed consent form * painful palpation of the lateral epicondyle * positive mill\&#39;s, maudsley\&#39;s and cozen\&#39;s tests * patients who have had complaints for at least 3 months exclusion criteria: * those who have had corticosteroid, prp, prolotherapy, hyaluronic acid etc. injections into the elbow area within 3 months or those who have received physical therapy * those with cervical radiculopathy * those who have had surgery on the elbow * those with an open wound on the elbow * those with a history of malignancy * those with rheumatological diseases * those with neurological diseases * pregnancy * infection
pilates mat versus cervical stabilization exercises on myoelectric activity of cervical muscles in forward head posture

Conditions: Musculoskeletal Diseases

Summary: see if there is no statistical significant difference between the effects of pilates mat versus cervical stabilization exercises on myoelectric activity of cervical muscles in young adults with forward head posture.

forward head posture (fhp) increases extension of the atlanto-occipital joint and the upper cervical vertebrae as well as flexion of the lower cervical and upper thoracic vertebrae. furthermore, this posture causes persistent and abnormal contraction of the suboccipital, neck, and shoulder muscles. additionally, the muscles around the head and shoulders, including the trapezius, sternocleidomastoid, suboccipital, and temporal, are affected by fhp, which further worsens postural deformity. fhp is the most common deviation from ideal head posture and is characterized by the head projecting forward into the sagittal plane such that it is anterior to the trunk. head in forward posture can add up to thirty pounds of abnormal leverage on the cervical spine, which pull the entire spine out of alignment, in addition, loss of the physiological lordosis could be a possible cause of pain due to muscular imbalance.

Eligibility criteria:
inclusion criteria: * subjects of both genders aged 18-25 years old with forward head posture will be included in this study * subjects have forward head posture if craniovertebral angle ≤ 50. * subjects complain non- specific neck pain for at least 3 months or at least two episodes of non-specific neck pain during the last three months. * normal body mass index exclusion criteria: * subjects with any spinal problems * subjects with experience in pilates exercises through the last 3 months of the start of intervention will be excluded from the study * previous surgery in the neck and shoulder regions * current participation in a structured exercises program * neurological symptoms of the upper extremities during screening tests (e.g., spurling test and upper limb tension tests) * red flags suggesting of cancer, infection, vascular insufficiency * cervical radiculopathy or myelopathy

Keywords: forward head posture craniovertebral angle pilates mat exercises
loma: long-term management of asthma

Conditions: Asthma

Summary: the purpose of this study was to determine whether the use of induced sputum cell counts could guide treatment of asthma more effectively than the use of symptoms and breathing tests. the main outcomes where the time to the first exacerbation and the number of exacerbations.

airway inflammation is an important component of asthma. it influences other components which include symptoms and airway functional (physiological) measurements. it is the primary target of treatment. however, it does not correlate closely with symptoms, need for symptomatic bronchodilator relief, or the physiological abnormalities. furthermore, it can be of different types. as a result, physicians are poor at recognizing its presence or type. this is important because eosinophilic inflammation is responsive to corticosteroid while non-eosinophilic is not responsive. the most comprehensive non-invasive or relatively non-invasive measurement of airway inflammation is by spontaneous or induced sputum cell counts. these are reliable, valid and responsive, the qualities of good measurements. they might therefore be clinically useful to guide individual treatment. in the present study we investigated this issue. we compared their use, in comparison with the use only of symptoms and spirometry, in preventing exacerbations of asthma. we chose prevention of exacerbations as the most important clinical outcome because these have the greatest impact on patient's quality of life, morbidity and healthcare utilization. the study comprised two phases. in phase 1, the minimum treatment to control sputum eosinophilia (as well as clinical criteria) in the sputum strategy, and clinical criteria in the clinical strategy, were established. in phase 2, this minimum treatment was maintained and patients were seen every 3 momths and at exacerbations. the primary outcomes were the relative risk reduction for the occurrence of the first exacerbation and the length of time without exacerbation over 18-20 months in phase 2 of the study.

Eligibility criteria:
inclusion criteria: 1. history of asthma for at least one year,confirmed objectively. 2. new or previously reviewed patients where the minimal treatment requirements have not been established within the last six months. exclusion criteria: 1. smokers or ex-smokers for less than 6 months with a smoking history of more than 10 pack years. 2. other pulmonary co-morbidity (other than mild or moderate chronic airflow limitation). 3. subjects having a co-existing illness that precludes them from the study. 4. inability to give informed consent due to mental or legal reasons. 5. pregnancy or lactation. 6. known non-compliance with medications.

Keywords: asthma treatment induced sputum cell counts asthma exacerbations eosinophilic bronchitis non-eosinophilic bronchitis
evaluation of the role of intravitreal tissue plasminogen activator in treatment of refractory diabetic macular edema

Conditions: Diabetic Macular Edema

Summary: purpose: to evaluate the effect of intravitreal injection of tissue plasminogen activator(tpa) in treatment of refractory diabetic macular edema(dme).


Eligibility criteria:
inclusion criteria: 1. type 2 diabetes 2. non proliferative diabetic retinopathy(npdr) stage of diabetic retinopathy 3. patients with refractory dme csme (patients with the last mpc at least 3 months before and no improvement was observed in bcva, macular thickness inoct, clinical examination and fundus photographs of patients ) 4. absence of pvd in the b-scan 5. absence of pvd in oct of macular area and optic disk 6. absence of pvd in slit lamp biomicroscopy(sle) 7. the last prp session was at least 3 months ago. 8. absence of traction on macula in clinical examination and oct exclusion criteria: 1. one eye patients 2. patients who are candidates for intraocular surgery. 3. patients with the history of glaucoma or ocular hypertension 4. patients with a history of vitrectomy in the study eye 5. not being able to refer for the next visits 6. eyes with cataract that makes the assessment of the macula impossible. 7. intraretinal hemorrhage at fovea that will interfere with oct. 8. bcva ≤ 0.1

Keywords: tissue plasminogen activator, clinically significant macular edema, refractory diabetic macular edema , posterior vitreous detachment
hybrid exercise training for weight loss

Conditions: Circuit-based High Intensity Interval Training; Body Composition; Resting Metabolic Rate; Habitual Physical Activity; Performance

Summary: in this study the investigators utilized a novel hybrid hiit (high intensity interval training) exercise training approach, the hybrid interval training (doit) workout that combines interval training, resistance exercise training and functional training in order to test the hypothesis that doit will be able to: i) reduce body mass, ii) improve body composition and iii) alter energy balance, of previously inactive, overweight/obese women.

in a controlled randomized, two-group, repeated measures design, 65 healthy, sedentary, premenopausal overweight or obese women were randomly assigned to one of three groups: (a) a control group (c, n=21) that participated only in measurements, (b) a training group (tr, n=14) that participated in a supervised 40-week doit workout exercise training program and (c) a training-detraining group (trd, n=14). during the first 20 weeks, tr and trd followed exactly the same training protocol. at the end of this period, tr continued training for 20 more weeks whereas trd terminated training for 20 weeks (detraining). anthropometric, metabolic, daily nutritional intake, habitual physical activity and performance measurements were performed in all groups at baseline, at 20 weeks and 40 weeks.

Eligibility criteria:
inclusion criteria: * (a) were sedentary (\ 10% of body mass ≤6 months before the study, g) participated in ≥80% of total exercise sessions, and h) had no symptoms of depression. exclusion criteria: * a) a recent febrile illness, b) history of muscle lesion, c) lower limb trauma, d) signs, symptoms or diagnosis of serious health complications or physical disability or other medical condition compromising safe participation in exercise training.
enhancing electronic health systems to decrease the burden of colon cancer, lung cancer, obesity, vaccine-preventable illness, and liver cancer

Conditions: Colon Cancer; Lung Cancer; Tobacco Use Cessation; Obesity; Pneumonia, Bacterial; Shingles; Hepatitis C

Summary: the purpose of clover is to utilize epic healthy planet to increase adherence to united states preventive services task force (uspstf) and centers for disease control and prevention (cdc) recommendations in adults age 50 and older.


Eligibility criteria:
inclusion criteria: - any patient who has a uc davis or uc irvine primary care provider (pcp) and is deficient in any of the following: colon cancer screening, lung cancer screening, tobacco cessation counseling, obesity counseling, pneumonia vaccination, shingles vaccine, and hepatitis c screening. exclusion criteria: - patients outside of the age limits or have an established pcp.
proof-of-concept study to determine the flow changes when stimulating two neural targets for the treatment of obstructive sleep apnea

Conditions: Sleep Apnea; Sleep Apnea, Obstructive; Sleep Disorder; Sleep Apnea Syndromes

Summary: this proof-of-concept study will evaluate the impact of surgically placing and stimulating the hypoglossal nerve and/or a second neural target ansa cervicalis, with a set of off-the-shelf electrode arrays.


Eligibility criteria:
inclusion criteria: * age above 18 years not under guardianship, under curatorship or under judicial protection. * body mass index (bmi) \< 35 kg/m2. * subject suffers from osa (15 \< ahi \< 80) documented by a sleep study performed during the past 36 months. * subject must be eligible for a diagnostic or surgical procedure. * written informed consent obtained from the patient prior to performing any study specific procedure. * willing and capable to comply with all study requirements, including specific lifestyle considerations, evaluation procedures and questionnaires for the whole duration of the trial. exclusion criteria: * major anatomical or functional abnormalities that would impair the ability of the electrode arrays to be positioned * significant comorbidities that contraindicate surgery or general anesthesia * significant tongue weakness * any other chronic medical illness or condition that contraindicates a surgical procedure or general anesthesia in the judgment of the investigator. * prior surgery or treatments that could compromise the placement and effectiveness of the electrode array systems: * airway cancer surgery or radiation, * mandible or maxilla surgery in the previous 3 years (not counting dental treatments), * other upper airway surgery to remove obstructions related to osa in the previous 3 months (e.g., uvulopalatopharyngoplasty (uppp), tonsillectomy, nasal airway surgery), * prior hypoglossal nerve stimulation device implantation. * currently pregnant, or breastfeeding during the study period

Keywords: sleep apnea
feasibility study of the addition of a personal trainer to the post-treatment regimen of breast cancer survivors

Conditions: Breast Cancer

Summary: the purpose is to examine the feasibility and preliminary effectiveness of the role of a personal trainer for non-metastatic breast cancer survivors to improve physical activity and well-being (in terms of quality of life).

after breast cancer treatment, many women are faced with effects of treatment such as changes in appearance, fatigue, and reduced quality of life as compared to the pre-disease state. an intervention to increase physical activity may be helpful to improve well-being and outcomes for women treated for breast cancer.

Eligibility criteria:
inclusion criteria: * female * post active breast cancer therapy (e.g. surgery and/or chemotherapy and/or radiation therapy), but may still be undergoing maintenance cancer therapy. * free of macro-metastatic disease * sedentary pre-cancer diagnosis: those individuals not participating in a regular exercise program or not meeting the minimal physical activity recommendations from the general surgeon which is accumulating 30 minutes or more of moderate physical activity on most days of the week * ability to provide informed consent * ability to provide a written physician's clearance * patients must be new to the survivorship clinic (within first 12 months). exclusion criteria: * medical conditions that would preclude participation in a weight-training program. * those who plan on relocating outside the greater pittsburgh area in the next 3 months of intervention.

Keywords: survivors physical fitness
study to compare u0267 against vehicle in subjects with plaque-type psoriasis two of two phase 3 studies

Conditions: Psoriasis

Summary: the purpose of the study is to demonstrate the safety and efficacy of u0267 in subjects with plaque-type psoriasis.


Eligibility criteria:
inclusion criteria: * male or female subjects at least 12 years old and in good general health. * mild to moderate plaque-type psoriasis exclusion criteria: * known allergy or other adverse reaction to calcipotriene or other vitamin d analogs; or to any component of the investigational formulations * history of hypercalcemia or of vitamin d toxicity. * diagnosis of generalized pustular or erythrodermic exfoliative psoriasis. * other serious skin disorder or any chronic medical condition that is not well controlled. * use of non-biologic systemic anti-psoriatic therapy or biologic therapy within four weeks of enrollment. * use of topical therapies that have a known beneficial effect on psoriasis, within 2 weeks of enrollment. * systemic medications for other medical conditions that are known to affect psoriasis within the past four weeks of enrollment. * use of any investigational therapy within 4 weeks of enrollment. * pregnant women, women who are breast feeding, or sexually active women of child bearing potential who are not practicing an acceptable method of birth control.

Keywords: plaque-type psoriasis psoriasis