Kornimate/medical-research-clean huggingface dataset:
study to investigate csl112 in subjects with acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: this is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of csl112 on reducing the risk of major adverse cv events \[mace - cardiovascular (cv) death, myocardial infarction (mi), and stroke\] in subjects with acute coronary syndrome (acs) diagnosed with either st-segment elevation myocardial infarction (stemi) or non-st-segment elevation myocardial infarction (nstemi), including those managed with percutaneous coronary intervention (pci) or medically managed.


Eligibility criteria:
inclusion criteria: * male or female least 18 years of age * evidence of myocardial necrosis, consistent with type i (spontaneous) mi * no suspicion of acute kidney injury * evidence of multivessel coronary artery disease * presence of established cardiovascular risk factor(s): 1. diabetes mellitus on pharmacotherapy or 2. 2 or more of the following: age ≥ 65 years, prior history of mi, peripheral arterial disease exclusion criteria: * ongoing hemodynamic instability * evidence of hepatobiliary disease * evidence of severe chronic kidney disease * plan to undergo scheduled coronary artery bypass graft surgery as treatment for the index mi * known history of allergies, hypersensitivity, or deficiencies to soy bean, peanut or albumin

Keywords: coronary artery disease heart disease cardiovascular disease acute myocardial infarction heart failure major adverse cardiovascular event multivessel disease peripheral artery disease cerebrovascular accident ischemic stroke hemorrhagic stroke atherosclerosis congestive heart failure valvular heart disease atrial fibrillation hypertension
fish oil (omega 3), immune function, and mood

Conditions: Inflammation

Summary: this study is designed to examine the effects of fish oil on immune function and mood.

the beneficial effects of fish oil (or eating fish more frequently) include reductions in triglycerides, blood pressure, and heart rate, as well as increases in hdl cholesterol, the "good" type of cholesterol. in addition, certain aspects of immune function also appear to show favorable responses to fish oil supplementation, and some studies suggest that fish oil helps to improve mood and decrease depression. this study is designed to examine how supplementation with omega-3 polyunsaturated fatty acids (key fish oil components) affects aspects of your immune response, and your mood; because some research suggests that people who eat more fish may do better during stressful times, the study will also examine how fish oil affects your immune response to stress, certain stress hormone responses, and your psychological response to stress. for detailed information about the study, please visit our website at http://www.stressandhealth.org

Eligibility criteria:
recruiting men and women ages 40-88 from the greater columbus ohio area. participation involves taking capsules for 4 months and completing 6 appointments (for a total of 19.5 hours) at ohio state. inclusion criteria: * healthy men and women * not currently taking any sort of fish oil or omega 3 supplement exclusion criteria: * use of blood pressure medicines, cholesterol-lowering drugs, steroids, or antidepressants * certain lifestyle habits such as smoking or exercising vigorously for 2 or more hours a week may also exclude applicants from participating

Keywords: affect inflammation
a pilot study of a home-based walking intervention for pancreatic cancer patients

Conditions: Cancer of Pancreas

Summary: despite evidence regarding the benefits of physical activity in various cancer patient populations, the effects of a home-based walking program for pancreatic cancer patients have been under-explored. the aims of the proposed pilot project are to: (1) assess the feasibility of implementing a 12-week, home-based walking program among pancreatic cancer patients; and (2) examine the effects of a 12-week, home-based walking program on quality of life (qol) and symptoms among pancreatic cancer patients.

among cancer patients, physical activity interventions can lead to improvements in qol and reductions in fatigue and pain. while pancreatic cancer patients may have physical restrictions that limit their participation in moderate to high-intensity exercise activities, empirical evidence suggests that even low-intensity, home-based walking programs can confer benefits for cancer patients. in this pilot study, 50 patients will be randomly assigned to receive either the walking intervention program or usual care (uc). assessments of quality of life, distress, and symptom burden will be completed at baseline (pre-intervention) and at follow-up (i.e. within 2 weeks post-intervention or approximately 12-14 weeks post-baseline). data from the proposed pilot study will inform the development of a larger randomized trial designed to improve qol and reduce morbidity in this patient population.

Eligibility criteria:
inclusion criteria: * patients aged 18 years or older * have histologically confirmed adenocarcinoma of the pancreas (including adenocarcinoma subtypes such as signet ring carcinoma, adenosquamous carcinoma, undifferentiated/poorly differentiated carcinoma, and mucinous carcinoma) * have an estimated life expectancy of greater than 3 months * have an eastern cooperative oncology group (ecog) performance status of 0, 1, or 2 * are undergoing treatment for pancreatic cancer at fox chase cancer center * have borderline resectable or unresectable locally advanced disease or metastatic disease exclusion criteria: * patients with islet cell/neuroendocrine or papillary cystic neoplasm * patients scheduled to undergo surgical resection for curative intent during study participation * patients receiving 3rd-line palliative chemotherapy * inability to communicate in english.
time-trend analysis of clinical characteristic and outcomes in patients with unprotected left main coronary artery disease treated with pci over a 10-year period

Conditions: Cardiovascular Diseases

Summary: surgical coronary bypass surgery (cabg) has been demonstrated to confer significant survival benefit over medical therapies patients with lmca in earlier clinical trials1,2,3 and therefore was the revascularization modality of choice for a long time. recently, several randomized controlled trials and meta-analyses have shown percutaneous coronary intervention (pci) to be non-inferior to cabg in the treatment of lmca disease4,5,6,7,8. pci is now considered to be an appropriate alternative to cabg for lmca disease in patients with suitable anatomy9,10. over recent decades, lmca pci has been performed in patients with increasing anatomical complexity and higher risk profiles (e.g. elderly, heart failure, renal failure etc). 11,12. in recent years, remarkable advancement in interventional techniques and technologies such as 2nd/3rd generation des and potent antiplatelet therapy have contributed to the improvement of pci success rates and reduction in complications and adverse events. knowledge related to long term temporal variation of clinical and procedural characteristics and outcomes in patients with lmca disease treated with pci will therefore be important to inform and define future treatment strategies. this proposal aims to evaluate time-trends and regional differences in clinical characteristics and outcomes of patients with lmca disease treated with pci in the asia-pacific region


Eligibility criteria:
inclusion criteria: * lp(a) ≥ 70 mg/dl at the screening visit * optimal ldl-cholesterol lowering treatment * optimal treatment of other cv risk factors * myocardial infarction: ≥ 3 months to ≤ 10 years prior to the screening visit, and/or * ischemic stroke: ≥ 3 months to ≤ 10 years prior to the screening visit, and/or * clinically significant symptomatic peripheral artery disease exclusion criteria: * uncontrolled hypertension * heart failure new york heart association (nyha) class iv * history of malignancy of any organ system * history of hemorrhagic stroke or other major bleeding * platelet count \<140,000 per μl * active liver disease or hepatic dysfunction
effects of esketamine combined with dexmedetomidine on postoperative sleep quality

Conditions: Hip Fractures

Summary: 1. eligible patients are randomly divided into experimental and control groups； 2. the experimental group is given esketamine combined with dexmedetomidine，while the control group is given normal saline； 3. the patients' sleep, pain, and cognition are followed up after surgery.

one day before surgery, the investigators collect baseline data from patients at the bedside. preoperative sleep quality is assessed using pittsburgh sleep quality index(psqi); three-minute confusion assessment method(3d-cam)is used to assess the incidence of delirium; cognitive function is assessed using montreal cognitive assessment(moca); the hospital anxiety and depression scale (hads) is used to assess patients' mood; wong-baker faces pain scale revision(fps-r) and numeric rating scale(nrs) are used to assess the patient's pain score at rest and during activity, and laboratory tests (hb, alb, k, na, cr, alb, e-gfr) are recorded. on the day of surgery, after successful neuraxial anesthesia, in the experimental group ，0.125mg/kg esketamine and 0.3ug/kg dexmedetomidine are diluted into 30ml of normal saline and continuously pumped for 20 minutes, followed by a micropump: 15ug/kg/h esketamine 0.02ug/kg/h dexmedetomidine to 96ml saline, continuous amount: 2ml/h, continuous pumping for 48h. morphine 1 mg is given epidural at the beginning of surgery；while in the control group, same amount of normal saline is given. the patients are followed up for sleep quality, pain and delirium incidence after surgery. long-term telephone follow-up of patients are focused on their cognitive function and recovery quality.

Eligibility criteria:
inclusion criteria: * age≥ 65 years old; * hip fracture surgery under neuraxial anesthesia; * signed informed consent. exclusion criteria: * asa classification≥ class v; * presence of neuraxial anesthesia contraindications: coagulation dysfunction, thrombocytopenia, neuraxial mass, puncture site infection, etc.; * patients with contraindications to esketamine (such as allergies, intracranial aneurysms, hyperthyroidism and glaucoma); * patients with contraindications to dexmedetomidine (allergies); * patients with severe cardiovascular diseases such as sick sinus syndrome, severe sinus bradycardia (heart rate \< 50 beats/min), atrioventricular block grade ii or above without pacemaker, unstable angina, severe valvular heart disease, severe arrhythmia, severe macrovascular disease with new york heart association class iii patients, etc.; * obstructive sleep apnea syndrome (stop-bang score \> 3 points); * patients with severe hepatic and renal insufficiency (such as child-pugh score iii, creatinine clearance \< 35 ml/min, preoperative dialysis); * those who have delirium, dementia, moderate to severe cognitive dysfunction and psychiatric disorders before the start of the trial and are unable to communicate and cooperate with the investigator.
response of immune system to flu vaccination in phts

Conditions: PTEN Hamartoma Tumor Syndrome

Summary: this study evaluates the cellular and humoral immune response to seasonal influenze vaccination in pten hamartoma tumor syndrome. all subjects will be administered flu vaccination, half of the subjects will be control subjects.


Eligibility criteria:
inclusion criteria: * must be diagnosed with phts based on genetic testing * must be a radboudumc patient * must be 18 years or older * must be mentally competent * must have provided written informed consent to participate in the study * must be able to adhere to visit schedule and available to complete the study exclusion criteria: * • known history of significant medical disorder, which in the investigator's judgment might confound the results of the study or pose additional risk to the subject by participation in the study * known hypersensitivity to previous influenza vaccinations (anaphylaxis) * must not be allergic to chicken eggwhite * pregnancy at start of study * immunocompromised patients and those receiving concomitant immunosuppressive therapy or other immune modulating drugs including chronic steroid treatment. * bleeding disorders including haemophilia and thrombocytopenia or treatment with anticoagulants(due to risk of intramuscular hematoma after injection) * must not have received vaccination with attenuated pathogens in the 4 weeks leading up to study. (measles, mumps, rubella, yellow fever, rotavirus, bcg, typhoid)

Keywords: phts pten vaccination
effect of robotic therapy on upper extremity with stroke

Conditions: the Effect of Virtual Reality on Stroke Rehabilitation

Summary: the purpose of this study is to determine how adding virtual reality assisted robotic treatment to traditional rehabilitation affects stroke patients' pain levels, functional status, and daily living activities.after conventional and robotic therapy each patient was evaluated the barthel index (bi), the fugl meyer assessment upper extremity (fma-ue), and the visual analogue scale (vas) were used to assess the patients' pain, daily living activities, and upper extremity motor function.

the purpose of this study is to determine how adding virtual reality assisted robotic treatment to traditional rehabilitation affects stroke patients' pain levels, functional status, and daily living activities. materials and methods: the study included 40 stroke patients. two groups of patients were created. group i also underwent 20 sessions of upper extremity robot-assisted therapy for 4 weeks, 5 days a week, for 30 minutes per session, in addition to receiving conventional therapy (5 days a week for 4 weeks, 1 hour each day). group ii only got traditional therapy. each patient was assessed both before and after the procedure. the barthel index (bi), the fugl meyer assessment upper extremity (fma-ue), and the visual analogue scale (vas) were used to assess the patients' pain, daily living activities, and upper extremity motor function.

Eligibility criteria:
inclusion criteria: - ischemic or hemorhagic hemiplegia * brunnstrom upper extremity motor stage ≥3 * at least 3 months have passed * modified ashworth score ≤2 * 18-85 year old patients with diagnosis of stroke exclusion criteria: * aphasia * cognitive impairment * mini mental test \<24 * deformity and / or contracture in the upper extremity * patients diagnosed with kbas

Keywords: stroke upper extremity robot-assisted therapy armeo
effects of balance training exercises on mobility in open and closed environment in children with visual impairments.

Conditions: Visual Impairment

Summary: visual impairment is used to describe any kind of vision loss, whether it's someone who cannot see at all or someone who has partial vision loss. visual impairment is classified on the basis of visual acuity like mild, moderate, severe, profound, near total visual impairment, no light perception (nlp). balance is defined as the ability to maintain one's equilibrium as the center of gravity when the cog shifts called (dynamic balance), as in walking and running, and while the center of gravity remains stationary (static balance). mobility is the ability of a patient to change and control their body position. physical mobility requires sufficient muscle strength and energy, along with adequate skeletal stability, joint function, and neuromuscular synchronization. this will be a randomized controlled trial. approval will be gained from the ethical committee of the riphah international university lahore, pakistan prior to the commencement of study. written informed consent will be taken from all the patients and all information and data will be confidential. subjects will be informed that there is no risk of study and they will be free to withdraw any time during process of study. 24 patients will be divided into two groups. group a will be the control group that will be given the baseline treatment of static balance training (static exercises like standing on balance board, bounce on one foot, heel rises/toe rises, standing on one foot, jumping on trampoline) and group b will be the experimental group that will be provided with baseline treatment along with dynamic balance training (cross, side and tandem walking, step up and down, jumping and hopping on floor). exercises will be given the 40 minutes with 2 sessions per week over the period of 8 weeks. pre and post treatment values will be evaluated. the tools used will be time up and go test, gmfm-88, wee fim. data will be analyzed using spss 22.0 and mean and standard deviation will be calculated.


Eligibility criteria:
inclusion criteria: * both gender * 08-14 age * visual acuity is 20/70 with possible correction * all participants are label with legally blind by an ophthalmologist. * able to follow the commands exclusion criteria: * those who were unable to complete follow-up tests. * no other neurological or orthopedic problems that could affect balance, and who could understand the instructions during the implementation of the exercises and tests.
bioelectric field imaging near human skin wounds

Conditions: Wounds

Summary: the investigators have developed a new non-invasive medical device called the bioelectric field imager. they plan to use this device to measure the electric field near small lancet wounds in 60 volunteers. their hypothesis is that the electric field is an early stimulus for wound healing and the magnitude of this field will vary with wound healing capability. the investigators will compare the electric fields near arm and leg wounds in males and females in the age groups of 18-30 and 65-80. in addition they will measure these wound fields in diabetics and near chronic ulcers.

we will first characterize the lateral electric field near reproducible skin wounds in healthy male and female subjects 18-30 years of age. a standard superficial, dermal wound 0.5 mm long will be inflicted using the ascensia microlet vaculance by bayer health care with a 21 gauge lancet on its deepest setting. this setting will penetrate the epidermis and stop within the dermis. we will first determine variability within the same individual by measuring the electric field near two wounds close to each other on the volar forearm. we will then determine the variability between different body regions by comparing the wound field near a lancet wound in the volar forearm and one in the leg. if hair is present it will be removed by shaving the wound site prior to wounding. by collecting these data from 10 males and 10 females in both age groups we can determine if there is a gender or age dependence to the field strength. finally we will determine the lateral electric field near lancet wounds in diabetics and near chronic skin wounds. if these fields are smaller than fields found near acute wounds, it would provide a rationale for future studies imposing electric fields to enhance wound healing.

Eligibility criteria:
inclusion criteria: * aged 18-30 years or 65-80 years * chronic leg ulcer present * diabetic exclusion criteria: * hemophilia * fever

Keywords: electric field wound current wound healing bioelectric field chronic ulcer diabetic diabetes aging
pulmonary vein isolation versus botulinum toxin injection plus pulmonary vein isolation in patients with atrial fibrillation

Conditions: Paroxysmal Atrial Fibrillation; Persistent Atrial Fibrillation

Summary: the investigators have conducted a prospective, double-blind, randomized study to assess the comparative safety and efficacy of two different treatment strategies, pvi only versus pvi plus bt injection, in patients with persistent and paroxysmal af. results were assessed after follow-up of at least 1 years with the use of an implanted monitoring device (imd).


Eligibility criteria:
inclusion criteria: * persistent and paroxysmal af exclusion criteria: * congestive heart failure * lv ejection fraction \< 35% * left atrial diameter \> 60 mm
hybrid ceramic on worn dentition patients

Conditions: Dental Wear

Summary: evaluation of hybrid composite-nanoceramic on material characteristic and clinical use over tooth wear patients.

composite resin is often used to restore patient's dental defficiency, and also the material to cover and protect weak tooth structure. in tooth wear patients, multiple factors attributing to destruct their teeth. the durability and strength of the resotrative material must be reinforced. nanoceramic infiltrated in composite resin may enhance its mechanical characteristics. therefore, hybrid composite-nanoceramic material may be effective for tooth wear patients.

Eligibility criteria:
1. tooth erosion/attrition/abrasion/abfraction patients 2. age above 20 years old 3. return at certain period during the trial 4. full understanding of written and spoken language 5. agree with the questionnaire

Keywords: dentistry
assessment of validity and reliability of the turkish version of the quality of life and related events assessment scale for pacemaker patients

Conditions: Cardiac Implantable Electronic Devices; Quality of Life

Summary: cardiac implantable electronic devices are widely utilized to lower the rates of morbidity and mortality from ventricular tachycardia and ventricular fibrillation, as well as the incidence of sudden cardiac death. although implantation of these devices increases survival rates, patients may experience acute and chronic complications. these complications include device dislocation and fracture, inappropriate shocks, pocket hematoma, or infection. furthermore, functional loss in the upper extremity may result from upper extremity restrictions that are applied for an excessively long time in order to ensure proper placement of the device following implantation, or from patients who choose to extend this period on their own initiative out of worry about device failure or dislocation. patients' quality of life may be negatively impacted by these issues as well as diminished exercise capacity, weariness, and weaker respiratory and peripheral muscles. a quality of life scale called 'the assessment of quality of life and related events (aquarel)' was developed by stoffmel et al. for patients using pacemakers. in this study, the validity and reliability study of the turkish version of the aqarel scale will be conducted.


Eligibility criteria:
inclusion criteria: * having a pacemaker implant and not having any complications at the last pacemaker check-up, * being in nyha i-ii-iii-iv class, * patients with no cooperation problems, * volunteering to participate in the study. exclusion criteria: * • patients with insufficient dementia or cognitive impairment due to multiple comorbidities (e.g., recent cerebrovascular accident and/or significant hypotension), * patients with a history of psychiatric illness, * patients with speech, hearing or intellectual disabilities.

Keywords: quality of life patient reported outcomes cardiac implantable electronic devices
mild versus potent corticosteroids as treatment for phimosis in children

Conditions: Phimosis

Summary: topical steroids are used as treatment for non-retractile foreskin in children for decades, but, there are disagreement among physicians about the optimum potency of the agent used. this study is designed to determine any difference in the beneficial effects of mild versus potent topical corticosteroids in treatment of non-retractile foreskin in children.


Eligibility criteria:
inclusion criteria: * children 2-16 with non-retractile foreskin exclusion criteria: * balanitis xerotica obliterans, balanitis, \<2yrs