Kornimate/medical-research-clean huggingface dataset:
evaluation of the indicaid™ covid-19 rapid antigen test

Conditions: Covid19

Summary: the indicaid™ rapid antigen test was used in real-world outbreak testing. the antigen test was used together with pcr testing. this study was designed to evaluate whether the addition of a rapid antigen test decreased time to results in a real-world setting.

description of the indicaid™ covid-19 rapid antigen test the indicaid™ rapid test by phase scientific is a lfa designed for the qualitative detection of sars-cov-2 nucleocapsid protein in nasal swab samples. sample collection and procedure to collect a sample, a nasal swab sample is collected by inserting the provided swab 1 inch into the nasal cavity. the swab is rubbed against the inside walls of both nostrils 5 times in a large circular path. the swab is then dipped into a buffer solution to elute the sample. finally, three drops of the buffer solution-specimen mix are applied to the lfa test device. after 20 minutes, the user observes the test device for the presence or absence of a test line that indicates detection of the sars-cov-2 antigen. an internal quality control line is included to indicate whether the test has been performed correctly. covid-19 outbreak screening with the lfa in this dual-track testing approach, the lfa is used to identify preliminary positives to trigger prioritization of sample processing for subsequent rt-pcr confirmatory testing. in approach a, a preliminary positive result from the lfa would expedite the corresponding patient vtm sample for laboratory-based rt-pcr. expedited testing would obtain results. in approach b, a preliminary positive result from the lfa result would trigger the testing of the corresponding patient vtm sample with an onsite rapid nucleic acid amplification test (cobas® sars-cov-2 \& influenza a/b nucleic acid test on the cobas® liat system, roche molecular diagnostics). in addition to the onsite rapid rt-pcr test, the corresponding patient vtm sample was also sent for expedited laboratory-based rt-pcr testing. all samples testing negative with the lfa were sent for rt-pcr testing.

Eligibility criteria:
inclusion criteria: * at least 5 years of age and report onset * at least two of the following covid-19 symptoms within 5 days or less: fever or chills, fatigue, sore throat, congestion or runny nose, cough, headache, diarrhea, shortness of breath or difficulty breathing, muscle or body aches, new loss of taste or smell, nausea, or vomiting. exclusion criteria: * that do not fit inclusion criteria or vulnerable populations
reducing shoulder complaints in employees with high occupational shoulder exposures

Conditions: Shoulder Pain

Summary: aim: to evaluate the effectiveness of shoulder-café (intervention) compared to shoulder-guidance (control intervention) with respect to shoulder exposures and shoulder complaints. hypothesis: the shoulder-café, which unifies education, diagnostic clarification, supervised and home-based shoulder exercises, and advice from a health and safety consultant on workplace interventions, will reduce shoulder exposures and shoulder complaints more effectively than an individual-oriented control intervention with home-based shoulder exercises and written general advice on workplace interventions.

introduction: shoulder complaints prevail in the working age population and constitute a common cause of contacts with general practitioners. in occupations with high mechanical shoulder exposures, these complaints are especially frequent. persons with high occupational mechanical shoulder exposures and shoulder complaints seem an obvious target group for secondary prevention efforts, and more research on interventions targeting shoulder complaints in occupations with high shoulder exposures is needed. the aim is to develop and evaluate a shoulder-café intervention to reduce high occupational mechanical shoulder exposures and prolonged shoulder complaints. the specific objectives are: i. to evaluate the effectiveness of the shoulder-café as compared to the control-intervention, the shoulder-guidance, measured on reductions in shoulder complaints. ii. to evaluate the effectiveness of the shoulder-café as compared to the shoulder-guidance measured on reductions in occupational mechanical shoulder exposures. iii. to identify the influence of shoulder exercises and reduced occupational mechanical shoulder exposures, respectively, on shoulder complaints. the hypothesis is that the shoulder-café will reduce shoulder exposures and shoulder complaints more effectively than the shoulder-guidance. furthermore, a hypothesis is that fear avoidance beliefs is reduced and the degree to which the participants feel informed about the nature of their complaints and their remedies is increased more effectively with the shoulder-café compared to the control intervention. method: the project consists of a two-armed, cluster-randomised controlled trial with randomisation at company level (objectives i and ii) and a prospective cohort study based on the cluster-randomised study (objective iii). follow-up: a questionnaire 3 and 9 months after end of intervention with e.g. oss.

Eligibility criteria:
inclusion criteria: * adults * employed in occupations with expected high mechanical shoulder exposures (industry, construction and service) * shoulder complaints * able to read and understand danish exclusion criteria: * previous shoulder surgery * breast cancer operation * pregnancy * sickness absence expected to continue into the intervention period

Keywords: shoulder pain occupational exposure clinical trial
the effect of virtual reality glasses on anxiety during surgery under spinal anesthesia

Conditions: VIRTUAL REALITY

Summary: the aim of the study is to evaluate the efficacy of virtual reality glasses on anxiety of the patients who underwent operations under spinal anesthesia during peroperative period. both control group and vr group will be carry out stai- traıt anxiety test before operation and trait test after operation. patients will be perform spinal anesthesia after standard sedation administration. after block reach adequate level for operation patients in vr group will wear the glasses and started to watch a documentary about birds and a sedative music by the headset. patients in control group will take standard anesthesia care. hemodynamic changes (systemic blood pressure, heart rate, respiration rate and pspo2) will be record in both groups.

the asa score i-iii patients undergoing operation in or under spinal anesthesia will be included in the study. patients randomly assigned to vr group or control group. patients will be carry out stai-trait anxiety test preoperatively and second stai test postoperatively. spinal anesthesia will be performed after standard iv midazolam administration in both groups. after block reach adequate level for operation patient will wear the glasses and started to watch a documentary about birds and a sedative music by the headset in vr group and patient will take standard anesthesia care in control group. the hemodynamic variables will be recorded during operation.

Eligibility criteria:
inclusion criteria: * age \>18 * patients who undergo surgery under spinal anesthesia * american society of anesthesiologists (asa) physical status classification i-iii exclusion criteria: * patients undergo urgent operations * patients have psychiatric disorders

Keywords: virtual reality anxiety spinal anesthesia
ai driven national platform for ct coronary angiography for clinical and industrial applications registry

Conditions: CAD; Coronary Artery Disease; Coronary Stenosis; Plaques; Epicardial

Summary: the overall aim is to build an ai driven national platform for ct coronary angiography for clinical and industrial applications (apollo) for automated anonymization, reporting, agatston scoring and plaque quantification in cad. it is a "one-stop" platform spanning diagnosis to clinical management and prognosis, and aid in predicting pharmacotherapy response.

coronary artery disease (cad), a blockage of the blood vessels, affects 6% of the general population and up to 20% of those over 65 years of age. cad is a leading cause of cardiac mortality in singapore and worldwide, with 19% of deaths in singapore due to cad (moh website). numbers of cad cases are increasing due to ageing and the higher prevalence of contributary diseases such as diabetes. computed tomography coronary angiography (ctca) is the first-line investigation for cad as indicated by the national institute for clinical excellence (nice) guidelines. recent prospective multicenter imaging study for evaluation of chest pain (promise) and scottish computed tomography of the heart (scot-heart) trials support ctca as the dominant means for evaluating coronary anatomy and physiology as it increases diagnostic certainty, improves efficiency of triage to invasive catheterization and reduces radiation exposure when compared to functional stress testing. currently, cad report generation requires 3-6 hours of a ct specialist's time to annotate scans, with inter-observer variability of 20%. in addition, there is no effective singular toolkit to analyse agatston scores (a measure of calcified cad), severity of stenosis, and plaque characterisation. these problems have severely constrained the effectiveness of ctca as a diagnostic and research tool. the investigators plan to build upon singapore's competitive advantages in artificial intelligence (ai) to provide a solution to these gaps.

Eligibility criteria:
inclusion criteria: 1. age ≥21 years old 2. signed informed consent 3. clinically indicated for evaluation by ctca exclusion criteria: 1. individuals unable to provide informed consent 2. known complex congenital heart disease 3. planned invasive angiography for reasons other than cad 4. non-cardiac illness with life expectancy \< 2 years 5. pregnancy 6. concomitant participation in another clinical trial in which subject is subject to investigational drug or device 7. cardiac event and/or coronary revascularization (percutaneous coronary intervention (pci) and/or coronary artery bypass grafting (cabg) and/or valvular repair/replacement prior to ctca 8. glomerular filtration rate ≤ 30ml/min 9. known allergy to iodinated contrast agent 10. contraindications to beta blockers or nitroglycerin or adenosine

Keywords: ctca ct coronary angiography
a study to investigate the antidepressant effect of lamotrigine in patients with bipolar disorder using lithium

Conditions: Bipolar Disorder; Bipolar Depression

Summary: this is a study that, in the first 16 weeks, investigates whether lamotrigine versus placebo offers effect on depressive episodes for patients with bipolar disorder (also known as manic depressive disorder) who use lithium. in the following 50 weeks it is investigated whether these patients experience effect on their depressive and/ or (hypo)manic episodes.

a multicentre, double-blind, randomised, fixed-dose evaluation of the safety and efficacy of lamotrigine (lamictal®) compared to placebo as add-on therapy to lithium in the treatment of bipolar depression followed by long-term prevention of relapse and recurrence of depression and/or mania in subjects with bipolar disorder

Eligibility criteria:
inclusion criteria: * patients with bipolar disorder (type i or type ii) currently suffering from depression that is at least moderate in severity according to a psychiatrist. * currently using lithium. * female subjects can't be pregnant or become pregnant during the study. exclusion criteria: * actively suicidal. * rapid cyclers. * suffering from significant personality disorders. * alcohol or substance dependent or abusive. * suffering from significant physical conditions.

Keywords: bipolar disorder bipolar depression lamotrigine
comparison of ovarian mild stimulation and controlled ovarian stimulation in poor ovarian responders

Conditions: Infertility

Summary: this is a prospective, randomized clinical trial to compare the efficiency and safety of mild stimulation and controlled ovarian stimulation protocol on the treatment of por. the randomization is achieved on the basis of a computer-generated randomization list in a 1:1 ratio.

500 poor ovarian responders will be equally randomized to two different ovarian stimulation protocol arms,i.e, mild ovarian stimulation(experimental arm) or controlled ovarian stimulation(control arm). in experimental arm, patients will received letrozole 5mg per day from cycle day 3 to 7 and recombinant follicle-stimulating hormone (fsh) 150 international unit (iu) on day 4 and 6. the dose of recombinant fsh is adjusted according to the ovarian response and the gonadotropin-releasing hormone(gnrh)antagonist(cetrotide) 0.25mg per day is administrated when the estradiol level reaches 200 pg/ml and the serum luteinizing hormone （lh）level rises above 2 times of basal lh level. in control arm,patients will be stimulated with short-acting gnrh agonist long protocol. after complete downregulation is achieved through gnrh-agonist, recombinant fsh 300 iu/d is given for 5 days, then the dose of recombinant fsh is adjusted according to ovarian response. the clinical and ongoing pregnancy rate and other secondary outcome parameters are compared between these two groups.

Eligibility criteria:
inclusion criteria: * a. poor ovarian responders b. normal bmi (18-25 kg/m2) c. regular menstruation (with cycle 23-35 days) exclusion criteria: * a. history of repeated ivf failure (previous ivf cycle \>2) b. serious adenomyosis c. polycystic ovary syndrome(pcos) patients d. history of allergic to ovulation induction medicines e. abnormal uterine cavity, i.e, intrauterine adhesion f. attending other clinical trials in the same period. g. history of systemic disease contradictory to coh or pregnancy.

Keywords: poor ovarian response in vitro fertilization mild ovarian stimulation controlled ovarian stimulation
uti prophylaxis with cranberry extract after female incontinence surgery

Conditions: Urinary Tract Infections; Incontinence

Summary: the risk of urinary tract infection (uti) following female incontinence surgery ranges between 6-48%. the literature has shown mixed results of the therapeutic efficacy of cranberry extract to prevent uti in females, with some promising preliminary work in the prevention of uti's following gynecologic surgery. the researchers will conduct a study of the effect of cranberry extracts on preventing urinary tract infections following mid urethral slings, which are the most common urinary incontinence procedures.

the researchers are going to perform a randomized, double-blind, placebo controlled trial of cranberry extract capsules for the prevention of uti following incontinence surgery. they will recruit patients from a single hospital in a 24 month duration. eligible participants are women undergoing elective incontinence procedures that does not involve fistula repair or vaginal mesh excision. the therapeutic regimen will be theracran one cranberry capsules containing 36mg of proanthocyanidins and placebo cranberry capsules and placebo capsules. both will be supplied by theralogix nutritional sciences. following randomization into treatment or placebo therapy, the participants will be asked to start prophylaxis on day of surgery for a duration of six weeks. the researchers will collect urine specimen via catheter upon insertion in the operating room. at time of discharge, the researchers will provide all participants with capsules for six weeks of the assigned regimen until they are seen for their post-operative visit. participants will be told to contact research staff immediately and collect a urine specimen should they experience urinary symptoms consistent with uti. the researchers will administer a brief structured interview regarding type and duration of symptoms and refer for treatment when necessary. urine will be cultured using standard microbiologic techniques for the presence of uropathogens at one clinical laboratory. participants will be asked to complete a self-administered questionnaire at the two week post-operative clinic visit and again at six weeks. at study exit, the researchers will collect capsule bottles to ensure and assess compliance.

Eligibility criteria:
inclusion criteria: * women undergoing elective incontinence procedures that does not involve fistula repair or vaginal mesh excision exclusion criteria: * women undergoing incontinence procedures involving fistula repair or vaginal mesh excision
amp as a better delivery system of adenosine

Conditions: Ischemia

Summary: adenosine and amp are substances normally present in the body. adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks. the problem in using adenosine is that it is taken up by cells and, therefore, very little of the adenosine we give by vein or in the artery actually reaches the tissue. we propose to use amp as a way to improve delivery of adenosine. amp is inactive by itself, but is converted to adenosine in tissue. we hope that by giving amp we will increase levels of adenosine in tissue. to see if this is true, we will give either adenosine or amp into the forearm artery while we measure how much adenosine reaches the forearm tissue.


Eligibility criteria:
inclusion criteria: * healthy volunteers * age 18-65 * non smokers exclusion criteria: * smokers * any chronic disease

Keywords: adenosine amp microdialysis blood flow
income volatility and mental health, full experiment

Conditions: Depression; Anxiety; Blood Pressure

Summary: income instability is a defining aspect of the lives of the poor, who also disproportionately suffer from poor mental and physical health. this research is the first to assess the causal effects of predictable and unpredictable income instability on the psychological and physical health of the poor. it will advance the scientific knowledge on the effects of economic instability as well as understanding of health gaps across populations.

the poor suffer disproportionally from poor mental and physical health. many causes for these differences have been considered, including low income. but, poor families' incomes are not only low, but also often unstable and unpredictable. this instability creates uncertainty about whether individuals will be able to safeguard their future well-being. according to the allostatic load framework, prolonged activation of physiological stress responses will cause "wear and tear" on the body, heightening risks of cardiovascular disease and of age-related metabolic diseases, promoting cognitive decline and dementia, and accelerating cellular aging. this research will study the causal effects of income instability on the psychological and physical health of the poor. the study's specific aims are to: 1) identify the causal effect of income instability on psychological health (e.g. depression, anxiety), and physical health (e.g. blood pressure), 2) decompose the effects identified in aim 1 into the effects of predictable and unpredictable instability and compare to the impact of increasing the average level of income, and 3) investigate the channels through which effects on health occur, including both economic and behavioral channels and estimate the impact of key moderating factors (e.g. age, baseline mental health). the trial will be conducted in northern ghana. it will manipulate income instability by varying the number of work hours (and hence earnings) of participants in a cash-for-work program. participants in the first treatment arm will have a fixed work schedule, with the same hours and earning each period. the hours and earnings of a second treatment arm will vary over time, but the fluctuations will be known in advance. finally, the number of work hours and earnings of a third treatment arm will fluctuate unpredictably. each of these arms will be compared to a control group that is surveyed, but not offered additional work. importantly, the study will vary income instability while holding the average level of income constant in order to disentangle the impact of instability from the level-effect. the study will create 1,867 new jobs that would not otherwise be available during the lean season when jobs are scarce. the intervention has been designed so that the job opportunity cannot make the participants worse off than they would otherwise have been in the absence of research.

Eligibility criteria:
inclusion criteria: * between ages of 18 - 60 * female * lives in a household with 5 or fewer adults exclusion criteria: * pregnancy

Keywords: income instability uncertainty
safety study of post tonsillectomy ibuprofen use in adults

Conditions: Secondary Post Tonsillectomy Hemorrhage; Primary Post Tonsillectomy Hemorrhage

Summary: the purpose of this study is to determine if ibuprofen use after electrocautery tonsillectomy increases the post-tonsillectomy hemorrhage rate. hypothesis: use of ibuprofen does not increase the post-tonsillectomy hemorrhage rate. primary outcome: rate of tonsillar hemorrhage following adult tonsillectomy in those receiving narcotic pain medications plus ibuprofen compared to those receiving narcotics alone. secondary outcome: determine whether ibuprofen, a non-steroidal anti-inflammatory drug (nsaid), decreases post tonsillectomy pain, narcotic pain medication use, or cost of pain management.

tonsillectomy is common procedure associated with significant post-operative pain typically managed by narcotic pain medication. narcotics, however, can have inherent unwanted side effects such as respiratory depression. in fact, a recent u.s. food and drug administration (fda) warning has reported deaths from respiratory distress that were associated with use of codeine in children after tonsillectomy. finding alternative pain management regimens therefore is essential in post-tonsillectomy care. non-steroidal anti-inflammatory (nsaid) medications may provide an effective alternative to narcotics, but use of nsaids routinely after tonsillectomy has been limited due to concern for theoretical increased risk of post-operative bleeding, this is likely true for nsaids such as aspirin. nsaids such as ibuprofen, however, are believed to have no greater risk of bleeding than baseline, but this has not been proven. recent, well-designed, prospective pediatric studies have demonstrated effective analgesia improvement with the addition of non-steroidal anti-inflammatory drugs such as ibuprofen to post-operative pain management regimens, and no increased rate of post-surgery bleeding. this has not adequately been studied in adults but could provide many patients significant pain relief in the post-operative period if it is shown to not increase post tonsillectomy hemorrhage rates, as already demonstrated in the pediatric population.

Eligibility criteria:
inclusion criteria: * adults 18 years old or older * scheduled for tonsillectomy exclusion criteria: * prisoners * pregnancy * allergy to ibuprofen * history of vasculopathy to include lupus or wegener's or disseminated intravascular coagulation (dic) * any other bleeding disorder to include von willebrand disease and others * active neoplasm of any kind * tonsillectomy in combination with any sleep surgical procedure or palatal procedure

Keywords: post tonsillectomy hemorrhage post operative hemorrhage complications tonsillectomy