Kornimate/medical-research-clean huggingface dataset:
long-term effects of arabinoxylans on intestinal barrier function

Conditions: Obesity; Overweight

Summary: the higher prevalence of overweight and obesity among the population contributes to increased incidences of chronic metabolic diseases. obesity is considered a low-grade systemic inflammatory condition through 1) production of pro-inflammatory cytokines by adipose tissue and 2) alterations in intestinal microbiota composition and associated increase in intestinal permeability. healthcare costs related to these diseases are rising; prevention or delay of onset of disorders associated with overweight is needed. administration of wheat arabinoxylans (naxus), a non-digestible carbohydrate, may change the intestinal microbiota composition and have beneficial effects on gut epithelial barrier, especially on permeability and innate immune function. objective: to assess the effects of naxus on intestinal barrier function, immune system performance and metabolic control. prebiotic properties of naxus will be studied. tolerance of the product in different doses will also be investigated.


Eligibility criteria:
inclusion criteria: * overweight men/women (bmi 28-35 kg/m2) * besides overweight, healthy human beings * fasting glucose \<7.0 mmol/l * normal hba1c (4.4 to 6.2%) * consistently stable body weight for at least 6 months (± 2 kg) exclusion criteria: * type 2 diabetes mellitus (defined as fasting plasma glucose ≥ 7.0 mmol/l); * gastroenterological diseases or abdominal surgery; * cardiovascular diseases, cancer, liver or kidney malfunction, disease with a life expectancy shorter than 5 years; * abuse of products; alcohol (\>20 alcoholic consumptions per week) and drugs * smoking * plans to lose weight or following a hypocaloric diet; * use of any medication, including vitamin supplementation, except oral contraceptives, within 14 days prior to testing; * regular use of laxation products; * use of antibiotics in the 90 days prior to the start of study. * administration of investigational drugs or participation in any scientific intervention study which may interfere with this study (to be decided by the principle investigator), in the 180 days prior to the study * known pregnancy, lactation (checked by a pregnancy test before start of study) * blood donation within 3 months before study period * prohibited use of pro-, pre- or synbiotics during study period and three months prior to start of study. a list with forbidden products will be provided (e4 preprobiotics). * self-admitted hiv-positive state * history of any side effects towards intake of pro- or prebiotic supplements of any kind

Keywords: prebiotics intestinal permeability gut barrier function immunity
optimized caloric-proteic nutrition in septic and septic shock patients

Conditions: Sepsis; Septic Shock

Summary: in this pilot randomized prospective controlled trial the investigators intend to compare the use of a nutritional therapy based on caloric intake determined by indirect calorimetry and high protein intake with nutritional regimen based on 25 kcal / kg / day and protein intake usually recommended for critically ill patients (1.4 to 1.5 grams / kg / day of protein).


Eligibility criteria:
inclusion criteria: * patients admitted to the icu with sepsis and septic shock according to 3rd international sepsis consensus conference definitions for sepsis and septic shock * mechanically ventilated * expected length of stay in icu ≥ 4 days * written informed consent obtained from authorized surrogates exclusion criteria: * pregnancy * requirement for inspired oxygen content (fio2) \> 0.60 * high output bronchopleural fistula

Keywords: loss of physical function
contrast enhancement on coronary computed tomographic angiography

Conditions: Coronary Artery Disease; Coronary Stenosis

Summary: computed tomographic angiography (cta) is an important prognostic tool with regard to the detection of coronary artery stenoses. both iodine delivery rate (idr; the amount of iodine delivered to the patient per second) and iodine concentration are decisive factors in the opacification of arterial vessels. there remains to be some debate in the literature about whether the use of high iodine concentration contrast media is beneficial compared to lower iodine concentrations. to date, there have not been any studies comparing intracoronary attenuation using concentrated contrast media lower than 300 mg i/ml at coronary cta. for a reliable comparison of cm with different iodine concentrations, adapted injection protocols insuring an identical idr (in g iodine per second) are mandatory. the investigators hypothesize that usage of lower iodine concentrations, while maintaining identical idr and total iodine load, will result in comparable diagnostical intra-vascular attenuation in cta.

to evaluate intravascular contrast enhancement and image quality in coronary cta using different iodine concentrations ranging from 240 to 370 mg iodine per ml, administered with an identical idr and total iodine load. to describe the effect of iodine concentration and flow rates on contrast bolus characteristics, eg time to peak, bolus homogeneity, injection pressure and patient comfort.

Eligibility criteria:
inclusion criteria: * atypical or typical chest pain exclusion criteria: * unstable angina * hemodynamic instability * history of cad * pregnancy * renal insufficiency (defined as glomerular filtration rate (gfr) \<45ml/min or \<60ml +diabetes * hr \> 90 bpm and the inability to receive beta-blockers and iodine allergy

Keywords: computed tomography coronary cta contrast media
study of ketorolac versus opioid for pain after endoscopy

Conditions: Kidney Calculi; Ureteral Calculi

Summary: a double blind randomized controlled trial designed to compare pain control and safety with ketorolac and oxycodone in the post-operative setting for patients undergoing ureteroscopy for treatment of urinary stones. patients are followed for five days after their surgery as they record their pain scores, medication utilization, and stent related symptoms.

pain is the leading cause for unplanned emergency department visits and readmissions after ureteroscopy (urs), making post-operative analgesic stewardship a priority given the current opioid epidemic. the investigators conducted a double-blinded, randomized controlled trial (rct), with non-inferiority design, comparing nonsteroidal anti-inflammatory drugs (nsaids) to opiates for postoperative pain control in patients undergoing urs for urolithiasis. patients were randomized and blinded to either oxycodone (5mg) or ketorolac (10mg), taken as needed, with 3 non-blinded oxycodone rescue pills for breakthrough pain. primary study outcome was visual analog scale pain score on post-operative days 1-5. secondary outcomes included medication utilization, side effects, and ureteral stent symptoms questionnaire (ussq) scores.

Eligibility criteria:
inclusion criteria: * patients with kidney or ureteral stones confirmed on imaging (ct of the abdomen pelvis) and who elect for definitive treatment via unilateral ureteroscopy at one of two hospital sites within a tertiary care institution * patients who post-operatively receive a unilateral ureteral stent * capable of giving informed consent * capable and willing to fulfill requirements of the study exclusion criteria: * active or history of peptic ulcer disease, gastrointestinal bleeding or perforation * history of coronary artery bypass graft surgery * history of a bleeding disorder * gfr less than 60 ml/min/1.73m2 (mdrd equation) * chronic use of opioid or other pain medication including nsaids (greater than 12 weeks) * known allergy to either ketorolac or oxycodone * known or suspected pregnancy * solitary kidney * patients taking anticoagulant medication or antiplatelet medication (e.g. warfarin, clopidogrel, pradaxa, rivaroxaban, apixaban etc). * inability to give informed consent or unable to meet requirements of the study for any reason
long-term extension of gtx-102 in angelman syndrome

Conditions: Angelman Syndrome

Summary: the primary objective of the study is to evaluate the long-term safety profile of gtx-102 in participants with angelman syndrome (as)

this study is a phase 3, long term extension (lte) which is open to participants rolling over from a prior gtx-102 clinical study. the lte study will evaluate the long-term safety and efficacy of gtx-102 in participants with as.

Eligibility criteria:
inclusion criteria: * signed informed consent from parent(s) or legal guardian(s). * prior participation in a clinical trial with gtx-102; the timing for the roll-over into this study from a prior gtx-102 study is based on the investigator and ultragenyx medical monitor's approval. * from the time of informed consent through the end of the study and for at least 6 months after the final dose of gtx-102, females of childbearing potential who are sexually active must use highly effective contraception or abstinence. males are able to participate if they agree to remain abstinent (refrain from heterosexual intercourse) or use acceptable contraceptive methods during the study and for at least 3 months after the final dose of gtx-102. exclusion criteria: * known hypersensitivity to gtx-102 or its excipients that, in the judgment of the investigator, places the subject at increased risk for adverse effects. * pregnant or breastfeeding or planning to become pregnant (self or partner) at any time during the study
use of immersive virtual reality to train the multisensory processing capacities of children aged 8 to 16 years-old with an autism spectrum disorder: single-center randomized pilot study in parallel groups - sevire. (sensory virtual reality)

Conditions: Autism Spectrum Disorder

Summary: autism spectrum disorder (asd) is defined as a neurodevelopmental disorder that affects the functioning and development of social communication (dsm5 - 2013). asd causes particularities in sensory treatments (auditory, visual), qualified as uni-modal. added to this, there is difficulties to deal with prevailing stimuli of the environment (pluri-modal) ; parents report the discomfort of their child in this situation with "noisy" behavioral manifestations. therapeutic social skills programs most often address the subject's lack of adjustment to their environment through understanding social rules and codes and cognitive treatment of situations. thus, in order to relieve the sensory modulation disorders which can be the cause of social adjustment difficulties, it's propose to exercise the sensory habituation of children with asd thanks to virtual reality scenarios restored in 3d immersion booth (the cave). the child will be exposed to multimodal stimulation during immersion sessions reproducing the conditions of an ecological environment. a therapist will accompany the child in the cave throughout the session. the investigators hypothesize that regular and repeated exposure to a simulated environment in the cave can improve multisensory treatment capacities and have a beneficial effect on the autonomy of children and adolescents with asd in everyday situations.


Eligibility criteria:
inclusion criteria: * child / adolescent aged 8 to 16 years, diagnosed with asd (dsm-5, ados, adi-r criteria). * without intellectual delay (qnv\> 70, wisc-iv or v, wais-iii or iv). * benefiting from a treatment program at the university center for child psychiatry (chru bretonneau-tours). * schooled in the ordinary school context (primary school, middle school, high school, ulis). * having expressed their agreement to participate in the study. * whose parents or legal representatives have signed written consent. * whose parents or legal representatives are affiliated or beneficiaries of a social security scheme. exclusion criteria: * neuromotor disorders. * uncorrected visual disorders. * hearing impairment. * known epilepsy. * anxiety syndromes identified. * hyper add / h type activity. * treatment with methylphenidate. - rare genetic syndrome.
role of genetic polymorphism in neuroplasticity involved in dysphagia recovery

Conditions: Stroke; Dysphagia

Summary: the purpose of this study is to assess the association of genetic polymorphism such as the brain-derived neurotrophic factor (bdnf), in neurogenic dysphagia in those with brain lesion.

neurogenic dysphagia attributable to acquired brain lesions, such as after stroke and after traumatic brain injury, are one of leading causes of chronic disability world widely and it is expected to substantially increase over the next two decades. among various sequalae, dysphagia can be observed in about 40% -60% of post-stroke patients and 20% -30% of them might suffer from recurrent aspiration pneumonia and may inhibit recovery and can even lead to death. recovery after brain lesions can be explained by specific molecular events. it is proven that genetic polymorphisms associated with impaired neural repair or plasticity might reduce recovery from stroke. not only for the motor recovery, but genetic polymorphism is also crucial for the recovery of swallowing after stroke, however, only limited amount of studies are available. therefore, it is urgent to determine whether the recovery of swallowing disorders after stroke is affected by the inherent polymorphism of the patient, whether the degree of recovery and brain plasticity associated with swallowing depend on the gene characteristics and polymorphism of the patient and whether recovery in swallowing parallel to the recovery observed in other functional areas (ie. hand recovery, truncal control recovery, adl recovery). based on the results of this study, results will be expected to help provide genetically tailored diagnosis and prognostication according to the gene polymorphism of the patient. optimized treatment of the patient is expected to contribute to prevention of respiratory complications and improve functional outcome related to swallowing after stroke.

Eligibility criteria:
inclusion criteria 1. patients who had been diagnosed with first ever brain lesions ( stroke and traumatic brain lessons) and referred to department of rehabilitation( in bucheon st. mary's hospital and national traffic injury rehabilitation hospital) 2. patients who were hospitalized for 30 days and were followed up at 3 months after the onset of brain lesions 3. patients who agree to participate in the study or if the guardian or legal representative agrees only if the patient has difficulties in consenting or consenting to participate directly in the language disability. 4. in the case of a suspected feeding swallowing disorder in the patient, the patient should be confirmed by vfss(videofluoroscopic swallwing study) or fees(fiberoptic endoscopic evaluation of swallowing) exclusion criteria 1. patients who do not meet the above criteria 2. patients with difficulty in collecting blood for genetic testing 3. patients who were not able to followed-up for 6 months(follow up loss patients) 4. patients with long-term parkinson's disease, alzheimer's disease, guillain-barre syndrome, myasthenia gravis syndrome, etc.

Keywords: gene polymorphism stroke dysphagia poststroke recovery
the effect of web-based training given to mothers of babies with congenital heart disease

Conditions: Mothers; Quality of Life; Self Efficacy; Training

Summary: this study was assessed the impact of a web-based education program provided to mothers of infants with congenital heart diseases on their quality of life and self-efficacy levels. the study is a mixed-method approach with a qualitative and pre-test post-test design, utilizing randomized controlled quasiexperimental type. the research was conducted with mothers of infants diagnosed with congenital heart disease who sought care at the pediatric cardiology outpatient clinic of a university hospital and were followed up. there are two groups in the study. web-based education was provided to mothers in the intervention group (n=30). no intervention was applied to the mothers in the control group (n=30) other than the outpatient clinic routine of the hospital.

materials and methods: study is a mixed-method approach with a qualitative and pre-test post-test design, utilizing randomized controlled quasiexperimental type. the research was conducted with mothers of infants diagnosed with congenital heart disease who sought care at the pediatric cardiology outpatient clinic of a university hospital and were followed up. there are two groups in the study. web-based education was provided to mothers in the intervention group (n=30). no intervention was applied to the mothers in the control group (n=30) other than the outpatient clinic routine of the hospital. "qualitative interview form, parent-infant introductory information form, quality of life scale and generalized perceived self-efficacy scale" were used. the research process had two stages; in the first stage, qualitative data was collected and after qualitative interviews with mothers, the content of the web-based training was created in line with the needs of the mothers. in the second stage, quantitative data were collected, and a web-based training program was applied to the intervention group and an outpatient clinic routine to the control group.

Eligibility criteria:
inclusion criteria: * for mothers; * having a baby with congenital heart disease * being over 18 years of age * being literate * being able to speak and understand turkish * there is no health problem that may prevent participation in training. * being able to use a computer/mobile phone * being able to use and have internet access * volunteering to participate in research for babies; * those born at or after the 37th week of gestation and those with congenital heart disease, aged 0-12 months * has not had heart surgery * babies who do not have any other chronic diseases exclusion criteria: * filling out forms incompletely * being a foreign national * having vision or hearing problems * to give up participating in the research * mothers and babies who have physical/mental problems that may affect the research results during the study period.

Keywords: congenital heart disease web-based education mothers infants care pediatric nursing
enhanced recovery after surgery for spk transplantation recipients

Conditions: Transplant Complication; Diabetic Nephropathy; Perioperative/Postoperative Complications

Summary: 108 patients underwent elective spk surgery were randomly divided into eras group (e) and routine care group (t). the eras group was consisted of evidenced-based systematic optimization approaches, while the control group received routine care.

primary results: the postoperative length of stay (los) and hospitalization costs; second results: post-operative analgesia score (nrs) , the incidence of post-operative nausea and vomiting (ponv) , urinary catheter removal time by 7 days , post-operative gastric tube indwelling time, the incidence of ambulation within 6 days . the dosage of dobutamine using , the dosage of norepinephrine using, and the total amount of fluid and urine volume . map and lactate level . peak systolic velocity (psv) and (resistance index) ri of grafts were checked between two groups.

Eligibility criteria:
inclusion criteria: 1. patients were aged 20-62 years 2. body mass index (bmi) of 18.5-32.9 kg/m2 3. voluntary participation for elective spk surgery 4. ersd and dn patients waiting for spk transplantation surgery. exclusion criteria: 1. history of allergy to narcotic drugs 2. cardiopulmonary insufficiency 3. congestive heart failure 4. myasthenia gravis 5. neurological disease 6. mental illness 7. severe liver dysfunction 8. hyperkalaemia 9. malignant hyperthermia 10. unwilling to participate in the study for any reason, or had participated in another study within the 3 months

Keywords: enhanced recovery after surgery, spk transplantation
jordan diabetes microclinic project

Conditions: Diabetes Mellitus, Type II

Summary: the purpose of the study is to provide participants in economically depressed areas of jordan essential knowledge, practical skills, and intimate support groups-called microclinics-for managing their diabetes. microclinics consist of 2-8 individuals from pre-existing social networks (friends, relatives, coworkers, neighbors, etc) that voluntarily participate in ongoing education and medical monitoring from local health care professionals, learning and practicing diabetes management strategies, sharing much-needed medical supplies, and exchanging social support in the form of regular micro-clinic meetings.

the global microclinic project seeks to empower people to prevent and manage diseases in economically depressed areas jordan. the project seeks to more broadly link health education opportunities in the form of lectures and seminars with practical experience through workshops and hands-on learning, ultimately resulting in the creation of microclinics. microclinics are intimate support groups of diabetic patients (2-8 per clinic) who meet in their homes and businesses in order to share the costs of maintaining medical monitoring equipment and supplies, come together to support one another in the management of diabetes, collectively utilize vital treatment options, and receive personalized screening, education and management tools from medical professionals. the microclinics concept is ideal for the management of chronic disorders such as diabetes, a disease which requires ongoing education about diet and exercise and regular monitoring of health indices such as blood glucose levels and weight change. indeed, the microclinics model has been established successfully in the west bank specifically to combat diabetes. the goal here is to extend the model to jordan and to establish microclinics in a collaborative effort with the royal health awareness society (rhas) and the jordanian ministry of health (moh).

Eligibility criteria:
inclusion criteria: * over 18 years old * mentally competent * have diabetes or pre-diabetes or brought a family member who was diabetic/pre-diabetic (diabetes: fasting blood glucose higher than 125 mg/dl; pre-diabetes: fasting blood glucose between 100 and 124 mg/dl.) exclusion criteria: * they do not meet the above criteria * they are pregnant * they have significant medical complications that prevent them from making changes to diet or level of physical activity.

Keywords: diabetes mellitus, type ii disease management chronic disease prevention and control education