Kornimate/medical-research-clean huggingface dataset:
foot neuromodulation for nocturnal enuresis

Conditions: Bedwetting

Summary: to determine the effects of electrical stimulation of the nerves in the foot on the incidence of nocturnal enuresis (bedwetting) in children

nocturnal enuresis is a very common and difficult to treat problem in the pediatric population which can have significant negative impact on a child's quality of life. apart from medications which can have significant side effects limiting their use, there is a lack of effective and safe treatment options for children with frequent nocturnal enuresis. if foot stimulation prior to bed does indeed improve the frequency of nocturnal enuresis, it may provide a safe and non-invasive therapeutic option.

Eligibility criteria:
inclusion criteria: 1. children ages 5 to 16 years old without any specific neurological disorder or urinary tract infection, clinically diagnosed as having nocturnal enuresis at least 4 episodes per month by history 2. currently having no daytime overactive bladder symptoms, i.e. urinary frequency, urgency, or daytime incontinence 3. having been assessed for and treated if applicable for behavioral etiologies of nocturnal enuresis - consuming excess fluids or specific bladder irritants 4. having been assessed for and treated if applicable for constipation exclusion criteria: 1. children with known neurological disorders which may be contributing to nocturnal enuresis episodes 2. children found through history to have significant behavioral causes of nocturnal enuresis including consumption of excessive fluids or known bladder irritants 3. children with chronic constipation who are non-compliant with previous pharmacologic efforts to treat. 4. children who are not adequately potty trained 5. children with significant daytime symptoms of overactive bladder including frequency, urgency, and daytime incontinence 5. children who do not tolerate initial stimulation training session in the urology clinic upon enrollment 6. children with any implantable medical devices such as a pacemaker will be excluded from the study note: any patient currently taking medication such as an anti-muscarinic or a tricyclic antidepressant for overactive bladder at time of enrollment will be eligible to participate and will be continued on their usual medication and dosage throughout the study.

Keywords: bedwetting
treatment with local ppargamma ligand in distal ulcerative colitis

Conditions: Ulcerative Colitis

Summary: treatment with ppargamma ligands have been shown to reduces intestinal inflammation in murine models of colitis. the aim of this study was to evaluate the effect of treatment with local ppargamma ligand (rosiglitazone) in distal ulcerative colitis.the patients are treated with rosiglitazone enema, once a day, for fourteen days. disease activity was assessed before and after treatment by endoscopical and clinical activity score.


Eligibility criteria:
inclusion criteria: * distal ulcerative colitis (mayo clinical score \> 7) * age \> 18 years * written consent exclusion criteria: * age \< 18 years * severe ulcerative colitis * systemic treatment with steroids or azathioprin within the last 3 month * known liver or kidney disease * severe heart failure * pregnancy or breast feeding

Keywords: ppargamma ligand rosiglitazone enema
obstructive sleep apnea (osa) anesthesia and positive airway pressure

Conditions: Obstructive Sleep Apnea

Summary: to determine if autotitrating positive airway pressure (apap) naïve patients with osa can successfully use apap following general anesthesia.


Eligibility criteria:
inclusion criteria: * patients with obstructive sleep apna exclusion criteria: * non conformers

Keywords: sleep apnea
allogenic umbilical cord blood and erythropoietin combination therapy for cerebral palsy

Conditions: Cerebral Palsy

Summary: this randomized control study is aimed to determine efficacy of umbilical cord blood and erythropoietin combination therapy for children with cerebral palsy.

cerebral palsy is a disorder of movement and posture that result from a nonprogressive lesion or injury of the immature brain. it is a leading cause of childhood onset disability through one's life. umbilical cord blood(ucb) is suggested as therapeutic method for cerebral palsy which resulted from animal studies. stem cells included in ucb is expected to exert therapeutic efficacy for functional recovery. it is also suggested that erythropoietin is useful to repair neurological injury in brain. the main mechanism of erythropoietin is supposed to be neuroprotection and neurogenesis which would reinforce the effect of stem cell as well. although autologous umbilical cord would be safe, the children who have problems at birth seldom have autologous umbilical cord blood. allogenic umbilical cord blood might be useful for these children if its effect is approved.

Eligibility criteria:
inclusion criteria: * known cerebral palsy * willing to comply with all study procedure exclusion criteria: * high risk of pneumonia or renal function deterioration after using of immunosuppressant * presence of known genetic disease * possibility of drug hypersensitivity which is related to this study remedy * history of previous cell therapy * poor cooperation of guardian,including inactive attitude for rehabilitation * intractable seizure disorder * autism

Keywords: umbilical cord blood stem cell cerebral palsy
manual therapy versus manual therapy and exercise and education in chronic neck pain

Conditions: Neck Pains; Posterior Cervical Pains; Posterior Neck Pain; Cervicalgia

Summary: the purpose of this study is to know which combination of treatments are the most effective in patients with non-specific neck pain. study design: this is a single-blind randomized controlled trial. (outcomes assessor). study population: men and women aged 18 to 60 years old with neck pain for at least 12 weeks. interventions: 3 groups will be treated for a period of 4 weeks (8 sessions total; 2 per week).

nonspecific chronic neck pain has a high prevalence and is very common in clinical practice. manual therapy (mt) studies of techniques like mobilization, manipulation, and therapeutic exercise, has been demonstrated effectiveness for the treatment of pain and disability in the neck. these investigations have thought of this treatments as individual interventions. thus, multimodal ways of treatment to improve patients with nonspecific chronic neck pain are necessary. the aim of this study is to evaluate the effectiveness of a multimodal treatment protocol compared to a unimodal treatment protocol in the medium-term, on patients with chronic non-specific neck pain. subjects are randomly allocated into three groups: mt group; mt+educational therapy (et) group; and mt+et+exercise group. each subject receive a 4 weeks period treatment (8 sessions). outcome measures include physical, somatosensory, and psychosocial characteristics; which are measure at 0, 4, 8, 16 weeks by a blinded assessor.

Eligibility criteria:
inclusion criteria: * the subjects for the study were selected if they fulfilled the following inclusion criteria: aged between 18 to 60 years old, head and/or neck pain for at least 12 weeks and having the willing to undergo the treatment. exclusion criteria: * if they had appearance of "red flags", rheumatologic diseases or any type of cancer, cervical surgery in the past, whiplash trauma and undergoing any type of treatment like physical therapy, manual therapy, osteopathy, chiropraxis, acupuncture during the last three months. all patients recruited for the study complained of pain localized in the neck and/or head region. initial screening was accomplished by telephone and eligible persons attended a evaluation appointment.

Keywords: manual therapy exercise education
pilot trial to test a nutrition application for making smart and healthy choices

Conditions: Diet Modification; Obesity

Summary: an innovative nutritional application (app) entitled "mynutricart" was developed to create a list of foods and beverages to help individuals make smart and healthy choices when purchasing foods at grocery stores based on the dietary guidelines for americans. this app was tested in a pilot trial to evaluate its feasibility, usability, and acceptability for making smart and healthy choices when purchasing food in grocery stores and test its effectiveness in improving food selection, dietary patterns, and weight status compared with the traditional nutritional counseling.

an innovative nutritional application (app) entitled "mynutricart" was developed to create a list of foods and beverages to help individuals make smart and healthy choices when purchasing foods at grocery stores based on the dietary guidelines for americans. a pilot randomized clinical trial was done to test the effectiveness of this app on food selection and purchase, dietary patterns, and weight loss during two months of intervention. we also assessed feasibility, usability, satisfaction and acceptability of the app. a total of 138 overweight and obese adults aged 21-45 years old who own a smartphone were invited to participate in this study. participants were randomized into two groups; (1) the intervention group used the app, which generated a healthy grocery list to use when purchasing foods in in the supermarket; (2) the control group had a traditional intervention with a nutritionist. to assess the impact of the intervention on dietary patterns, participants completed three 24-hour dietary recalls, a short food frequency questionnaire (ffq) and provided grocery receipts at baseline and at the end of the study (8 weeks later). weight and height were also performed before and after the intervention. feasibility, usability, satisfaction, and acceptability of the nutrition app were assessed at the end of the study using a questionnaire.

Eligibility criteria:
inclusion criteria: * overweight/obese adults * aged 21-45 years * main household shopper (responsible for \>50% of the household grocery shopping) * shopping at a grocery store at least once a week * owner of a smartphone (iphone or android) with internet access * willingness to be randomized into one of the two groups. exclusion criteria: * use of other apps * participating in weight loss programs * pregnant women * individuals with chronic health conditions * individuals with reported food allergies
effect of beraprost sodium (berasil) on hemodialysis

Conditions: Arteriovenous Fistula Patency

Summary: there is no randomized control study to determine if the beneficial effects of beraprost sodium could improve the patency of arteriovenous fistula in hemodialysis patients. therefore, this study is aimed to demonstrate the use of beraprost sodium can improve the patency of arteriovenous fistula in patients undergoing hemodialysis. this study is prospectively randomize controlled open-label trials in patients who newly made artificial arteriovenous fistula for hemodialysis. this study is a pilot study, and the target number of subjects is 60 in total, 30 in the treatment group and 30 in the control group. after randomization, the treatment group takes a beraprost sodium for 6 months and the control group does not take placebo. treatment lasts for 6 months after dosing but continues until the patient changes the renal-replacement therapy method or falls under the exclusion criteria. the patient should visit at 1, 3, and 6 months after arteriovenous graft surgery to check the access site after graft surgery. the doppler ultrasound test is performed to measure the access blood flow rate and patency of arteriovenous fistula.

this study is a prospective randomized controlled open-labeled trial of patients undergoing hemodialysis under the diagnosis of end stage renal disease. the subjects were divided into the treatment group and the control group through random assignment under the condition of receiving hemodialysis steadily and followed up for 6 months. after randomization, the treatment group received beraprost sodium (berasil) for 6 months (24 weeks) and beraprost sodium will be provided by astellas pharma korea, inc. patients were randomly assigned within 2 days after successful arteriovenous graft surgery, and the treatment group started taking 120 mcg of berasil, while the control group did not take placebo to replace beraprost sodium.

Eligibility criteria:
inclusion criteria: * patients who meet all of the following criteria 1. patient who newly made artificial arteriovenous fistula for hemodialysis 2. patients who agree to participate in the test and sign a consent form 3. patients who had diabetes exclusion criteria: * patients under 18 years old, 80 years old or older * patients with a high risk of bleeding (hemophilia, capillary weakness, upper gastrointestinal bleeding, urinary tract bleeding, hemoptysis, vitreous hemorrhage, etc.) * women who are pregnant or have a possibility of pregnancy * platelet count ≤ 75000 * patients taking anticoagulants or antithrombotics * patients with galactose intolerance, lactase deficiency or glucose-galactose malabsorption
the impact of artificial sunlight on human sleep and circadian rhythms

Conditions: Sleep; Circadian Dysregulation; Mood

Summary: the purpose of this study is to examine, in healthy controls, whether led lighting that has a color spectrum similar to that of sunlight is able to differentially impact mood, circadian rhythms, sleep, and behavior, as compared to standard fluorescent lighting.


Eligibility criteria:
inclusion criteria: * good self-reported health * normal color vision exclusion criteria: * no sleep disorders * no extreme chronotype * regular smoker * significant hearing loss * depression * alcohol use disorder * use of illegal drugs * pregnant
celecoxib versus naproxen for prevention of recurrent ulcer bleeding in arthritis patients

Conditions: Arthritis; Cardiovascular Diseases; Cerebrovascular Disorders

Summary: the aim of this study is to compare celecoxib plus a ppi (esomeprazole) versus naproxen plus a ppi (esomeprazole) in preventing recurrent ulcer bleeding in arthritis patients with a history of ulcer bleeding who require concomitant asa. we hypothesized that among patients with a history of ulcer bleeding who require concomitant asa, celecoxib plus esomprazole would be superior to naproxen plus esomeprazole for the prevention of recurrent ulcer bleeding.

nonsteroidal anti-inflammatory drugs (nsaids) are the most commonly consumed drugs worldwide for the relief of pain and arthritis. however, the use of nsaids increases the risk of ulcer bleeding by 4-fold. current evidence indicates that combination of conventional nsaids and a proton pump inhibitor (ppi) reduces the risk of ulcer complications. the alternative strategy is to replace conventional, non-selective nsaids with nsaids selective for cyclooxygenase-2 (cox-2 inhibitors). recently, there are concerns about the cardiovascular safety of cox-2 inhibitors and conventional nsaids. because of such concern, patients requiring anti-inflammatory analgesics who have cardiovascular risk factors (e.g. smoking, hypertension, hyperlipidemia, diabetes) should receive prophylactic low-dose aspirin. however, concomitant low-dose aspirin negates the gastric sparing effect of cox-2 inhibitors and augments the gastric toxicity of nonselective nsaids. thus, gastroprotective agents such as ppis should be co-prescribed to patients with high ulcer risk who are taking aspirin plus a cox-2 inhibitor or a nonselective nsaid.

Eligibility criteria:
inclusion criteria: 1. age \>18, 2. a history of endoscopically proven gastroduodenal ulcer bleeding, 3. h. pylori negative 4. a history of cardiothrombotic disease requiring asa, and 5. anticipated regular use of nsaids for the duration of trial exclusion criteria: 1. concomitant use of anticoagulants; 2. a history of gastric or duodenal surgery other than a patch repair; 3. the presence of erosive esophagitis, 4. gastric outlet obstruction, 5. renal failure (defined by a serum creatinine level of more than 200 umol/l), 6. pregnancy, 7. terminal illness, or 8. cancer
the effect of high dose vitamin c on the liver function in chronic hepatitis patients

Conditions: Chronic Hepatitis; Chronic Hepatitis C; Chronic Alcoholic Hepatitis

Summary: the investigators will evaluate the efficacy of high dose vitamin c in chronic hepatitis patients whose serum liver enzymes are elevated more than upper limit.

the changes of laboratory findings including serum transaminase levels, serum albumin levels, child-pugh score, meld score, and apri score will be evaluated.

Eligibility criteria:
inclusion criteria: 1. chronic hepatitis c patients * positive anti-hcv antibody more than 6 months * serum alanine aminotransferase 40 - 80 iu/l for more than 6 months * not indicated for antiviral therapy with interferon and ribavirin 2. chronic alcoholic hepatitis * significant alcohol drinking history and no other cause of chronic hepatitis * serum alanine aminotransferase 40 - 80 iu/l for more than 6 months exclusion criteria: * chronic hepatitis b, autoimmune hepatitis, primary biliary cirrhosis, wilson's disease, hemochromatosis, other chronic hepatitis except chronic hepatitis c or alcoholic hepatitis * decompensated liver cirrhosis * platelet \< 50,000/ul or white blood cell \< 1,500/ul * need and willing for antiviral therapy * significant renal dysfunction (gfr \< 30 ml/min/kg) or history of renal stone * hepatotonic drug (i.e. silymarin, garlic oil, aronamin gold) usage within 2 weeks * pregnancy, lactating woman
effect of electrical stimulation on forward head posture

Conditions: Forward Head Posture; Rounded Shoulder Posture

Summary: the study aims are: 1. to investigate the effect of electrical stimulation (interferential current) on forward head posture and protracted shoulder in adolescents. 2. to investigate the effect of electrical stimulation on cervical pain, cervical rom, neck muscle strength, and quality of life in adolescents with forward head posture and protracted shoulder.

forward head posture (fhp) is commonly defined as the protrusion of the head in the sagittal plane so that the head is placed anterior to the trunk. it can occur because of anterior translation of the head, and it is claimed to be associated with an increase in upper cervical extension, lower cervical flexion, or both. patients with fhp often experience neck pain and disability, it is associated with shortening of the upper trapezius, the posterior cervical extensor muscles, the sternocleidomastoid muscle, and levator scapulae muscle. thus, fhp may contribute to neck and shoulder pain. the prolonged uses of mobile phones and computers have led to a variety of musculoskeletal disorders, especially related to the neck as: forward head posture (fhp), rounded shoulders (rs), upper cross syndrome, mechanical neck pain etc. fhp is one in which the upper cervical convexity is increased and the lower cervical convexity is decreased causing anterior weight bearing of the cervical spine. it is also known as scholar's neck or reading neck. electrical muscle stimulation (ems) has been used as a complementary training method, applied either locally or to the whole body. it activates muscles artificially through various electrical current forms, which are delivered through electrodes on the target muscles. interferential current (ifc) is an established therapy which is used to treat pain and also effective for providing relaxation of muscles. the application of ifc at the medium frequency which suggests higher penetration of the electrical stimulation in the tissue by reducing tissue impedance

Eligibility criteria:
inclusion criteria: * girls aged between (15-18) years old. * normal weight with bmi ranging from (16-25). * adolescents with mild and moderate forward head posture(fhp). * adolescents with mild and moderate neck pain. * adolescents with protracted shoulder. exclusion criteria: * cervical disc. * previous shoulder trauma within last 6months. * shoulder surgery. * cervical fracture. * congenital posture deformity. * inflammatory disease, spinal tumor, spinal compression, spinal cord infection. * taking any medication for pain

Keywords: electrical stimulation interferential current adolescence
the association between variation in oxygen saturation (sco2) and incidence of postoperative cognitive dysfunction (pocd) in a population of elderly patients admitted for emergency surgery.

Conditions: Cerebral Saturation; Cognitive Impairment; Emergencies

Summary: there is no study of the association between sco2 and pocd in non-cardiac, thoracic or vascular surgery. the few studies found in cardiac, thoracic and vascular surgery show an incidence up to 50% with a variation of the sco2 threshold which varies between 15 and 25% according to the studies. age is the main risk of ocdd. the management of this pathology should be early to avoid loss of autonomy of the patient. finding a relationship, if it exists, would therefore significantly improve the mortality and morbidity of the said patient.


Eligibility criteria:
inclusion criteria: * age ≥ 65 years * non-cardiac, thoracic and vascular emergency surgery * surgery under general anesthesia * asa i, ii or iii * simple information without consent * patient affiliated to social security exclusion criteria: * inability to understand * patient under tutelage, or curatorship or deprived of public right * asa iv * history of severe dementia mmse \<20 * personal or familial history of malignant hyperthermia * history of allergy or hypersensitivity to anesthetic products used * contra-indication to cisatracurium®: myasthenia gravis * contra-indication to sevoflurane® * contra-indication to local anesthetics * indication of use of a ketamine®-type hypnotic (modification of the bis) * indication of use of nitrous oxide * history of cranial trauma * neuromuscular pathology * spinal anesthesia * cardiac, thoracic or vascular surgery * surgery not performed in emergency * neurochirugia in the context of cranial trauma * any surgery that does not allow the use of the nirs (impossibility of positioning of the electrodes by the location of the surgical field).
contrast-enhanced ultrasonography combined with blue dye as dual-tracer for sentinel lymph node biopsy

Conditions: Breast Neoplasms; Neoadjuvant Therapy; Sentinel Lymph Node Biopsy

Summary: false negative rate (fnr) in patients who has accepted neoadjuvant therapy is high. blue dye and radioisotope as dual-tracer can decrease fnr. several large clinical trials showed that using dual trace with blue dye and radioisotope can reduce the fnr to less than 10%. but radioisotope is still not approved in china and can cause radiocontamination. a novel dual-tracer which can decrease the fnr in patients after neoadjuvant therapy is urged to be explored. contrast enhanced ultrasonography (ceus) can make the lymphatic drainage path and sentinel lymph nodes visible. retrospective studies found that ceus can locate sln precisely. so this clinical trial aim to evaluate fnr, detective rate and numbers of sln by using ceus combined with blue dye as dual-tracer in sentinel lymph node biopsy in breast cancer patients after neoadjuvant therapy and the accuracy of ceus for the diagnosis of lymph node metastasis before and after neoadjuvant therapy.


Eligibility criteria:
inclusion criteria: * ≥18 years old female； * ecog：0 - 1； * biopsy confirmed invasive breast cancer； * ct1-4n0-3； * signed informed consent. exclusion criteria: * inflammatory breast cancer； * received ipsilateral axillary surgery previously； * during pregnancy.

Keywords: contrast enhanced ultrasonography