Kornimate/medical-research-clean huggingface dataset:
epidemiology of impaired coagulant balance in diabetes

Conditions: Cardiovascular Diseases; Heart Diseases; Diabetes Mellitus; Blood Coagulation Disorders

Summary: to determine the nature, extent and molecular mechanisms responsible for impaired fibrinolysis in white, black, hispanic and american indian populations with respect to the presence or absence of diabetes. the overall objective is to determine whether impairments of fibrinolysis underlie subclinical and clinical vascular disease in diabetes in specific populations with and without accelerated microvascular disease.

background: the results of this project should clarify the extent to which results obtained in experimental animals pertain directly to diabetes in human subjects. the study will also assist in the interpretation of results from clinical studies and from platelet activation experiments. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
risperidone-induced hyperprolactinemia treated with bromocriptine

Conditions: Schizophrenia; Hyperprolactinemia

Summary: antipsychotic drugs can cause a clinically relevant hyperprolactinemia due to blocking the dopamine receptors in the pituitary.schizophrenic patients suffering from a neuroleptic-induced hyperprolactinemia will be examined endocrinologically. adverse drug effects and diagnoses will be confirmed by measuring hormones.

antipsychotic drugs can cause a clinically relevant hyperprolactinemia due to blocking the dopamine receptors in the pituitary.depending on its concentration hyperprolactinemia causes a median hypogonadism with estrogen insufficiency in women and testosterone insufficiency in men by inhibiting the pulsatile gnrh-secretion.the hyperprolactinemia-induced symptoms have been successfully medicated for years with dopamine agonists like bromocriptine. in patients with psychiatric diseases hyperprolactinemia is usually not treated with dopamine agonist fearing a reexacerbation of the underline psychiatric disease. in a few studies and casuistically the treatment of neuroleptic-induced hyperprolactinemia with bromocriptine has been shown to be effective without causing reexacerbation of psychotic symptoms. schizophrenic patients suffering from a neuroleptic-induced hyperprolactinemia (in extremis galactorrhoea and amenorrhoea. in women, loss of libido and erectile dysfunction in men) will be examined endocrinologically. adverse drug effects and diagnoses will be confirmed by measuring hormones (prolactin, lh, fsh, testosterone, estradiol). in case of a clear symptomatic, neuroleptic-induced hyperprolactinemia patients will be medicated with bromocriptin. therapeutical success will be determined endocrinologically in week 0, 1, 2, 3, 4, 8, 12, 16, 20 and 24 together with a psychiatric examination (panss, ham-d, simpson-angus scale (sas)). safety of therapy will be ensured by the close meshed psychiatric examinations.

Eligibility criteria:
inclusion criteria: * female and male schizophrenic patients. * antipsychotic treatment with risperidone. * diagnosis of a clinically relevant hyperprolactinemia. * no indication of disturbance of the somato-, cortico or thyreotropic hypophysis-axis (igf-1, cortisol, acth, tsh, ft3, ft4) exclusion criteria: * severe somatic disease, especially coronary disease. * acute psychotic exacerbation. * pregnancy

Keywords: schizophrenia hyperprolactinemia risperidone bromocriptin
safety and efficacy study of pirfenidone to treat grade 2 or above radiation-induced lung injury

Conditions: Radiation Pneumonitis

Summary: the purpose of this study is to assess the safety and efficacy of pirfenidone capsules to treat grade 2 or above radiation-induced lung injury patients.


Eligibility criteria:
inclusion criteria: 1. 18-70 years old (include 18 and 70 years), male or female 2. the pathological diagnosis of lung cancer, with non-small cell lung cancer (nsclc) staging iiia or iiib, and small cell lung cancer (sclc) in council deadline 3. general condition assessment, ecog score of 0-1 4. enough heart, liver and kidney function, such as ast, alt, ldh≤2 times uln such as plasma total bilirubin, creatinine ≤1.5 times uln; hematopoietic function enough, such as neutrophils ≥4.0 x109 / l, platelets ≥100 x109 / l 5. the expected survival at 6 months or more 6. subject is able to eat solid food 7. the initial radical thoracic radiotherapy treatment 8. the clinical diagnosis of radiation-induced lung injury in grade 2 or above 9. the duration of radiation-induced lung injury in less than 1 month 10. signed informed consent exclusion criteria: 1. radiation-induced lung injury has entered the chronic phase 2. a history of chronic bronchitis, emphysema, or a history of cor pulmonale 3. lung resection surgery 4. cancer progression 5. pulmonary infection 6. associated with other serious diseases: such as occurred within 6 months of myocardial infarction, uncontrolled diabetes etc. 7. with active peptic ulcer 8. pregnant women and patients with mental disease 9. those who participate in clinical trials of other drugs within 3 months 10. investigator judge does not apply to participate in the trial
efficacy of ultrasound-guided prp versus corticosteroid injection in patients with ulnar neuropathy at elbow

Conditions: Ulnar Neuropathy at Elbow

Summary: this study was be performed on 60 patients with ulnar neuropathy at elbow diagnosed clinically and by electrophysiology and/or ultrasonography selected from physical medicine, rheumatology \& rehabilitation department, faculty of medicine, tanta university. patients were be randomly divided into 2 groups: group i: will undergo a single ultrasound-guided deep perineural injection with 3ml prp at the thickest part of the ulnar nerve. prp will be prepared by prp method. group ii: will undergo a single ultrasound-guided deep perineural injection with 1ml corticosteroid (triamcinolone acetonide, 40mg/ml) mixed with 1ml lidocaine hydrochloride.


Eligibility criteria:
inclusion criteria: * patients with ulnar neuropathy at elbow diagnosed clinically and by electrophysiology and/or ultrasonography. exclusion criteria: 1. patients with severe ulnar neuropathy at elbow according to gu's classification. 15 2. brachial plexopathy, peripheral neuropathy, and cervical radiculopathy. 3. history of recent elbow trauma or operation. 4. malignant neoplasm. 5. pregnancy. 6. bleeding disorders. 7. factors affecting nerve healing process e.g., tobacco use and systemic corticosteroid administration. 8. contraindications for prp injection: 1. significant renal or hepatic dysfunction. 2. critical thrombocytopenia. 3. hemodynamic instability. 4. septicemia. 5. local infection at the site of the procedure. 6. consistent use of nonsteroidal anti-inflammatory drugs within the last two weeks. 7. local injection at the suspected treatment site within the last month. 8. recent fever or illness. 9. hemoglobin level \<10 g/dl. 10. platelet dysfunction disorders.
a pilot study to assess the accuracy of blood pressure assessment by the omron heartguide smartwatch

Conditions: Hypertension; Cardiac Disease; Surgery

Summary: the accuracy of devices like the recent fda-clearance of the omron heartguide™ blood pressure sensor in robust clinical settings remain in question and thus form the underpinning of this research study. the objective of this pilot prospective study is to assess the accuracy of the omron blood pressure sensor as compared to arterial line blood pressure monitoring.

the purpose of this study is to assess the accuracy of the omron heartguide™ smartwatch in measuring blood pressure and heart rate as compared to standard post-operative blood pressure and heart rate monitoring with an arterial line and heart monitor. hypertension affects about 75 million americans and is the leading cause of cardiovascular disease (heart attacks and strokes), resulting in about 1,000 deaths per day. only 50% of patients have their blood pressure adequately managed thus necessitating a better solution. current limitations to hypertension management in non-icu or non-surgical settings include: 1) infrequent measurements, 2) inherent data variability, 3) white coat hypertension, 4) non-compliance, or 5) poor patient-provider follow-up. a majority of patients have their blood pressure measured only during clinic visits. a wearable blood pressure sensor that takes multiple measurements per day will allow for a new level of granularity among measurements. with more continuous measurements, patients and physicians can work together to identify the onset and progression of hypertension before it causes irreversible damage to the heart, kidneys, and brain. during testing, each subject will wear the omron heartguide™ smartwatch. both right and left wrist circumferences will be measured prior to placing the device. all patients will be on continuous telemetry according to standard clinical practice on the icu. each patient will be outfitted with the omron heartguide™ smartwatch (opposite extremity of the arterial line). an omron bp reading will be obtained at the same time as the arterial line reading. four readings in total will be obtained for each patient. all four readings may occur on the same day or may be occur over several days.

Eligibility criteria:
inclusion criteria: * age \> 18 years * post-operative cardiac surgery patients on the icu floors at the cleveland clinic main campus * wrist size range ranging from 16 cm to 19 cm exclusion criteria: * wrist size range smaller than 16 cm or larger than 19 cm * use of a radial artery graft for coronary artery bypass grafting

Keywords: wearable devices blood pressure arterial line hypertension post operative cardiac surgery
restoration of life role participation through cognitive and motor training for tbi

Conditions: Traumatic Brain Injury

Summary: the purpose of this study is to restore life role participation for those with tbi by customizing, applying, and testing integrated cognitive and motor training protocols that were successful in populations with impairments similar to tbi. the treatment protocols are based on principles of brain plasticity and re-learning, required to restore cognitive and motor function. the intervention targets an array of impairments that are obstacles to life role participation. these include cognitive attention and executive control; motor control for upper limb function; balance and gait; and cognitive executive control of simultaneous cognitive and motor tasks required by everyday tasks. the intervention utilizes training specificity, framing the intervention within functional task and life role activity component practice.

the investigators will use an assessment and treatment decision schema that has been successful in restoration of life role participation for stroke survivors and a comparable schema used for cognitive training for tbi patients. the subject assessment and decision schema will be used to identify for each subject, the optimal array of impairment interventions. the proposed treatment will optimize outcome by customizing the intervention and use of technologies, while ensuring the application of the array of impairment interventions required to produce restoration of function and life role participation. the investigators will target an array of impairments preventing participation in life role activities, which will include dyscoordination and weakness of upper limb, impaired balance, gait deficits, and impaired attention and executive function. in treatment, the investigators will use a dual-task paradigm combining motor and cognitive training, with treatment extending to the every day environment. treatment will be up to 5 times/wk, 5hrs/day for 12 weeks.

Eligibility criteria:
inclusion criteria: * medically stable * age \> 18 years * ability to walk at least with the minimum assistance of one person or an assistive device * at least 6 months post injury * ability to follow 2 stage commands exclusion criteria: * pacemaker * acute medical conditions * potential subjects will undergo a screening evaluation to determine eligibility for study entry

Keywords: tbi motor learning robotics functional electrical stimulation
anastrazole plus gnrh-agonist in the treatment of endometriosis recurrence

Conditions: Endometriosis

Summary: the aromatase inhibitor (anastrazole) plus long acting gnrh agonist leuprolide acetate will be tested for the treatment of women with endometriosis recurrence compared with classical gnrh analog treatment. pain symptom disappearance and disease free time during follow-up will be the outcomes for establishing which medical treatment is the best in endometriosis recurrence treatment.

endometriosis is a chronic disease affecting 5-10% of women in reproductive age, showing recurrence after surgery at least in 20-50% after 5 years of follow-up. aromatase inhibitor plus gnrh analog may be more effective than gnrh agonist alone in the treatment of endometriosis recurrence.

Eligibility criteria:
inclusion criteria: * women affected by endometriosis showing recurrence of pain symptoms, previous surgery for endometriosis exclusion criteria: * presence of other systemic diseases

Keywords: endometriosis recurrence pelvic pain aromatase inhibitor
treatment of neurogenic incontinence by surgery to cut the filum terminale

Conditions: Neurogenic Incontinence; Dysfunctional Voiding

Summary: the target population of this study is children with primary or secondary daytime urinary incontinence, who have failed to improve adequately despite compliance with at least 6 months of standard medical therapy. the study hypothesis is that patients who under go cutting the filum terminale - the string-like lower end of the spinal cord - will have improved bladder function at 6-month follow up. bladder function and its effects on quality of life will be measured before surgery and at 6-month follow up.


Eligibility criteria:
inclusion criteria: * primary or secondary daytime urinary incontinence, persistent over at least 6 months of medical treatment. * abnormal urodynamic testing * normal conus on magnetic resonance imaging of the spine * dysfunctional voiding symptom scale score greater than 6 for girls or greater than 9 for boys exclusion criteria: * bladder outlet obstruction * bladder atony * congenital anorectal malformation * additional diagnoses independently associated with neurogenic bladder dysfunction * encephalopathy precluding reasonable expectation of attainment of continence * inability to comply with medical management * unwillingness to comply with initial or follow up urodynamic testing

Keywords: incontinence dysfunctional voiding neurogenic bladder disturbance filum terminale spinal cord tethering conus
muscle typology and strength training adaptations

Conditions: Muscle Fiber Type; Exercise; Training Frequency

Summary: the overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. in a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. for the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers. male and female adult participants (18-45y) will be recruited. the subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using h-mrs. in total 21 subjects (11 slow and 10 fast subjects) will participate. subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm a and leg a will train 3 times per week and arm b and leg b will train 2 times per week. before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).


Eligibility criteria:
inclusion criteria: * fast or slow muscle typology * 18 - 45 years old * no strength training experience exclusion criteria: * vegan/vegeterian diet * supplement intake * chronic diseases * hypertension, * smoking * medication use * coagulation disorder, infectious diseases

Keywords: strength training muscle typology
collection and characterization of objective measures to explore the specificity of algorithms

Conditions: Hearing Loss

Summary: the aim of this descriptive study is to collect and describe the characteristics of objective measures to explore the specificity of algorithms.


Eligibility criteria:
inclusion criteria: * candidate for cochlear implantation with the ci532 or ci512 devices * 18 years of age or older at the time of enrolment * normal cochlea anatomy, established via pre-operative computer tomography * willingness to participate in and to comply with all requirements of the protocol exclusion criteria: * prior cochlear implantation in the ear to be implanted * ossification or any other cochlear anomaly that might prevent complete insertion of the electrode array * abnormal cochlear anatomy on pre-operative computer tomography or magnetic resonance imaging * additional handicaps that would prevent participation in evaluations * pregnant and breast feeding women, prisoners, or anyone in custody * unrealistic expectations on the part of the subject, regarding the possible benefits, risks and limitations that are inherent to the procedure
effects of bladder training and pelvic floor muscle training on the symptomatology of overactive bladder syndrome

Conditions: Overactive Bladder Syndrome

Summary: the question is whether vesical training and tmap can be used in isolation without treatment of overactive bladder syndrome? also will be evaluated in urinary symptoms, a function of the map, a quality of life and a satisfaction of the women with the treatment offered.

bladder training includes as resources the educational program, lifestyle modifications, as a strategy to suppress urgency and as programmed urges to improve the control of urgency and incontinence; increase bladder capacity, and thus prolong the intervals between such as urination; giving the patient a confidence in the bladder control. already, a justification for the use of tmap is a contraction of the pelvic floor muscles (map) inhibits detrusor contraction, improving the symptoms of detrusor overactivity.

Eligibility criteria:
inclusion criteria: * women with iuu and / or ium with a predominance of urinary urgency, capable of contracting maps adequately, and who agree to participate in the study, signing the informed consent form. exclusion criteria: * women with a diagnosis of glaucoma, myasthenia gravis, urinary tract obstruction, neurological and chronic-degenerative diseases, decompensated diabetic patients and patients with complete denervation of the pelvic floor, pregnancy, abnormal genital bleeding, impairment of cognition, inability to fill in the diary voiding, genital dystopias beyond the vaginal introitus and urethral sphincter defect. patients may not be in use or have used anticholinergics, tricyclic antidepressants or local hormone therapy within the six months prior to the study.

Keywords: overactive bladder syndrome
satiety of high-protein ramen noodles

Conditions: Appetitive Behavior

Summary: the aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. in addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles.

the aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. in addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles. subjects meeting the eligibility criteria will be recruited and offered a 2-condition, randomized, crossover postprandial study. participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. at our clinic, in random order, participants will consume: 1) one portion of high-protein instant ramen noodles (71 g; chef woo, borealis foods); 2) an isocaloric, weight matched portion of standard instant ramen noodles. the participants will have to finish consuming the noodles within 15 minutes. water will be provided at the time of breakfast and for the next two hours. in the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-yy, and ghrelin), and glucose and insulin. visual analogue scales will also be administered to assess subjective hunger and satiety. at 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed. subjects will leave the clinic at this point. the process will be repeated for the second condition after at least 7 d washout period.

Eligibility criteria:
inclusion criteria: * body mass index 20-30 kg/m2 exclusion criteria: * unwilling or unable to have an iv catheter inserted * body weight \<110 pounds * diabetes (any type) * fasting capillary glucose ≥100 mg/dl * unstable systemic medical condition •\>10% change in body weight in the prior 3 months * medications that affect appetite or glucose regulation * prior bariatric surgery * uncontrolled hypertension (i.e., unmedicated blood pressure \>130/90 mmhg) * intolerance, dislike or allergy to the study food * current or recent (within 6 months) tobacco use * high alcohol consumption (\>14 drinks/week) * currently following a weight loss diet * irregular menstrual cycle * currently pregnant or lactating * principal investigator discretion (e.g., disrespectful or inappropriate interactions with study staff