Kornimate/medical-research-clean huggingface dataset:
observational study to evaluate efficacy and remission status for schizophrenia patients under atypical treatment

Conditions: Schizophrenia

Summary: the objective of this study is to evaluate under routine clinical setting the efficacy and remission status from treatment of 2nd-generation antipsychotic in patients who is upon acute episode or not achieving remission under regular treatment from schizophrenia/schizoaffective disorder. this study will collect in real-life practice the severity of schizophrenia by clinical global impression (cgi), also evaluate the criteria of schizophrenia remission applying 8 items of positive and negative syndrome scale (panss) from andresen working group, the montgomery and asberg depression rating scale (madrs), and the global assessment of functioning scale (gaf). side effect of movement disorder will be evaluated by drug induced extrapyramidal symptoms scale (diepss). tolerability for treatment will be monitored by documenting spontaneous reports on adverse events as well as change in body weight.


Eligibility criteria:
inclusion criteria: * patients with acute episode (first or relapse), or upon revisit and identified not achieving remission of schizophrenia or schizoaffective disorder (according to remission criteria of schizophrenia) * male or female aged between 18 and 65 years * patients recruited from both in-patient and out-patient clinics * patients who are cooperative, by judgment from investigators, and the use of oral antipsychotic considered adequate exclusion criteria: * pregnancy or lactation * patients who, in the opinion of the investigator, pose an imminent risk of suicide or a danger to self or others * known intolerance, lack of response, or contraindication to prescribed atypical antipsychotic, as judged by the investigator * administration of a depot antipsychotic injection within one dosing interval (for the depot) before enrolment and patients prescribed with clozapine within 3 months prior to enrolment

Keywords: schizophrenia remission status by 8-item panss
study of a series of patients treated for retrograde cricopharyngeal muscle dysfunction syndrome

Conditions: Deglutition Disorders

Summary: r-cpd syndrome (retrograde cricopharyngeal dysfunction syndrome) is an inability to burp. it is a syndrome whose diagnosis is clinical, and for which there is effective treatment. recently treated in the united states (first publication in 2019), this syndrome affects many patients in france and is currently unknown. this study concerns a series of patients treated at the university hospitals of strasbourg for a syndrome of retrograde dysfunction of the cricopharyngeus muscle having been treated by injection of botulinum toxin into the cricopharyngeus muscle.


Eligibility criteria:
inclusion criteria: * major subject (≥18 years old) * subject treated by injection of botulinum toxin into the cricopharyngeal muscle after having had a diagnosis of r-cpd in consultation between january 1, 2022 and december 31, 2022 * subject not opposing the reuse of their data for the purposes of this research. exclusion criteria: * subject having expressed opposition to participating in the study, * subject under judicial protection * subject under guardianship or curatorship

Keywords: deglutition disorders dysphagia cricopharyngeus muscle circular sphincter esophagus botulinum toxin
correlation between quality of life and aerobic physical fitness of patients with a systemic right ventricle

Conditions: Congenital Heart Disease

Summary: congenital heart disease (chd) is the most common congenital malformations. the right ventricle in the sub-aortic position, or "systemic right ventricle" is one of these complex cardiac diseases. several studies show that adults with chd and especially systemic right ventricle have reduced exercise capacity. in addition, studies have shown that there is a correlation between alteration of aerobic physical capacity and alteration of right ventricular systolic function. understanding and assessing the determinants of the physical capacity of patients with systemic right ventricles and evaluating their quality of life could allows us to improve their therapeutic management and also to expand patient indications to a program cardiac rehabilitation. this can benefit them on their exercise capacity, their tolerance to exercise and their quality of life. the aim is to study the correlation between the quality of life and the aerobic physical fitness of patients with a systemic right ventricle and to determine the clinical and paraclinical parameters that have an impact on the aerobic physical fitness of these patients. the quality of life of patients with a systemic right ventricle will be compared to that of the general population.

100 patients will be enrolled in this study. 25 sites will participate to the enrollment, belonging to the french national network for complex congenital heart diseases (m3c) . patient is included during his annual medical check-up. quality of life questionnaire and other examinations are performed during this site visit. its is a part of his usual care. no supplementary visit, directly related to the research, are necessary.

Eligibility criteria:
inclusion criteria: * patient over 18 years of age * patient with a right ventricle in the systemic position * patient having undergone an annual assessment in accordance with the esc (european society of cardiology) 2010 recommendations: clinical examination, ecg, echocardiography, cardiopulmonary exercise test (with vo2) exclusion criteria: * objection of the patient * impossibility of performing an exercise test * inability to understand and / or complete the questionnaire

Keywords: systemic right ventricle quality of life vo2 oxygen uptake exercise test congenital heart disease
evaluation of the accuracy, safety and robustness of a single-input-single-output (siso) model-based predictive closed-loop system to guide patient-individualized icu sedation

Conditions: Coronary Artery Disease

Summary: the aim of this study is to investigate the accuracy, safety and robustness of a single-input-single output (siso) model-based predictive closed-loop system to guide patient-individualized icu sedation.


Eligibility criteria:
inclusion criteria: * patients in the immediate post-operative phase after an coronary artery reconstruction surgery. * age \>= 18 years * informed consent obtained before the surgery exclusion criteria: * severe renal failure defined by the rifle classification levels risk, failure and end-stage kidney failure * severe hepatic failure defined by a bilirubin level of \>= 3 mg/dl and/or a prothrombin level of \< 50% before the surgery * low ejection fraction defined as \< 40% * age \< 18 years * postoperative bleeding so that a new surgery is necessary * history of cardiovascular accident (cva) * history of copd * age \> 75 years * postoperative cardiac index \< 2.2 for more than 2 hours * svo2 \< 60% for more than 2 hours * hypotension with a map \< 60 mmhg for more than 2 hours * sedation agents other than remifentanyl and propofol including also catapressan, risperdal, etumine * remifentanyl dose exceeding 0.5 µg/kg/min. * absence of informed consent

Keywords: patients entering the post-operative cardiac intensive care unit following coronary artery reconstruction surgery.
an augmented reality based system for neglect detection, assessment, and rehabilitation

Conditions: Stroke

Summary: the aim of this phase is to examine the feasibility and acceptability of the augmented reality (ar)-based and electroencephalography (eeg)-based neglect detection and rehabilitation tool.


Eligibility criteria:
inclusion criteria: * ages18 and older * acute stroke * admitted to inpatient rehabilitation * presence of neglect (behavioral inattention test total score \<129, or scoring below pre-defined cutoff score in at least one of the six subtests) * more than 10/% missed targets on the augmented reality screening test * intact vibration (positive test on vibration sensation test) * intact auditory function (positive test on auditory sensation test) * english speaking exclusion criteria: * inability to follow one-step directions at least 80% of the time * current diagnosis of dementia, parkinson's disease, multiple sclerosis, or space-occupying tumor * metal in the head that causes interference with the eeg system * self-report of previous positive photic stimulation test
realizing effectiveness across continents with hydroxyurea (reach)

Conditions: Sickle Cell Disease

Summary: reach is a prospective, phase i/ii open-label dose escalation trial of hydroxyurea for for pediatric patients with sickle cell anemia (sca). the short-term goal is to obtain critical pilot data regarding the feasibility, safety, and benefit of hydroxyurea for children with sca in multiple distinct research settings in africa. based on that information, the longer-term goal is to make hydroxyurea more widely available for children with sca in africa, particularly those identified with sca through expanded newborn screening programs.

study objectives 1. to assess the feasibility of conducting a prospective research study using hydroxyurea therapy for sca in sub-saharan africa (including adherence to monthly clinic visits and laboratory assessments, and medication compliance) 2. to monitor the safety of hydroxyurea therapy, specifically documenting hematological toxicities (cytopenias) and serious infections (bacterial and malarial) 3. to evaluate the benefits of hydroxyurea therapy, using both laboratory (e.g., fetal hemoglobin, hemoglobin, white blood cell count) and clinical parameters (e.g., pain, hospitalization, growth) 4. to explore the pharmacokinetic and genetic basis for any observed inter-patient variability in the clinical or laboratory response to hydroxyurea. 5. to evaluate the economic cost of providing hydroxyurea therapy in the reach study sites. 6. to investigate the effects of hydroxyurea dose escalation on laboratory and clinical parameters

Eligibility criteria:
inclusion criteria 1. pediatric patients with documented sickle cell anemia (typically hbss supported by hemoglobin electrophoresis, complete blood count, and peripheral blood smear) 2. age range of 1.00-9.99 years, inclusive, at the time of enrollment 3. weight at least 10.0 kg at the time of enrollment 4. parent or guardian willing and able to provide written informed consent, with child's verbal assent as per local irb/ethics board requirements 5. willingness to comply with all study-related treatments, evaluations, and follow-up exclusion criteria 1. known medical condition making participation ill-advised, (e.g., acute or chronic infectious disease, hiv, or malignancy) 2. acute or chronic severe malnutrition determined by impaired growth parameters as defined by who (weight for length/height or height for age \>3 z-scores below the median who growth standards, as defined in appendix i) 3. pre-existing severe hematological toxicity (temporary exclusions) 1. anemia: hb \<4.0 gm/dl 2. anemia: hb \<6.0 gm/dl with arc \<100 x 109/l 3. reticulocytopenia: arc \<80 x 109/l with hb \<7.0 gm/dl 4. thrombocytopenia: platelets \<80 x 109/l 5. neutropenia: anc \<1.0 x 109/l 4. blood transfusion within 60 days before enrollment (temporary exclusion) 5. hydroxyurea use within 6 months before enrollment (temporary exclusion)

Keywords: africa
diaphragmatic speckle tracking during spontaneous breathing trial

Conditions: Weaning; Spontaneous Breathing Trial; Mechanical Ventilation; Speckle Tracking; Strains; Diaphragm

Summary: currently, measurement of transdiaphragmatic pressure (pdi) using oesophageal and gastric balloons is the gold standard for the assessment of diaphragmatic effort. this technique is relatively invasive and its interpretation may be complex. the diaphragmatic longitudinal strain (lsdi) and strain rate (lsrdi) might provide additional information in the assessment of diaphragmatic effort and movement during sbt, allowing early detection of diaphragmatic dysfunction. patients will be monitored during a 30-120 minutes sbt consisting of no assistance on the ventilator using cpap with a pressure level of 0 cmh2o. parameters to evaluate diaphragm function will include diaphragmatic strain (lsdi and lsrdi), diaphragmatic thickening fraction (tfdi), and airway occlusion pressure (δp0.1 and δpocc). these parameters will be measured immediately before ('baseline') the sbt, as well as 2 minutes ('early' assessment), 15 ('intermediate' assessment) and 30 minutes ('late' assessment) after the beginning of the sbt.


Eligibility criteria:
inclusion criteria: * consecutive adult patients (≥18 years old) undergoing mechanical ventilation for at least 24h (regardless of the reason of intubation) * patients fulfilling criteria for an sbt * patients will have to be able to trigger ventilator breaths with a reasonable level of assistance, * patients with lack of severe impairment in gas exchange, * patients that not require significant hemodynamic support. * patients will be recruited by the study coordinator following completion of informed consent from the patient or legally authorized substitute decision maker. exclusion criteria: * use of pressure support during the sbt. * severe hemodynamic instability (\>30% increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min). * severe or very severe chronic obstructive pulmonary disease (copd) according to the gold criteria (stage iii: fev1 30-50% predicted; stage iv: fev1 \< 30% predicted). * known or suspected severe or progressive neuromuscular disorder likely to result in prolonged or chronic ventilator dependence * clinical judgement of the attending physician.

Keywords: weaning spontaneous breathing trial mechanical ventilation speckle tracking strains diaphragm
new protein bar for physically active people

Conditions: Muscle Mass; Inflammation; Regeneration Muscle

Summary: post-exercise nutrition is an important factor in a nutrition plan for physically active subjects. focusing on that, the serbian group is developing protein bars enriched with sports supplements. slovenian partner group will investigate the effect of new protein bar consumption on body composition, biochemical parameters, and muscle regeneration after training. the new bar will be compared with a commercially available bar.

the clinical study will be performed on 10 elite handball players from slovenia handball club. it will be designed as a crossover study. half of the participants will consume the new bar for five days and the other half will consume the control bar. after the five-day washout period, the groups will consume the bar which was not consumed in the first period. at baseline, at the end of every intervention and washout period, the blood samples will be withdrawn, and the body composition will be analyzed. the analyzed biochemical parameters will be basic serum parameters, such as fasting glucose, total cholesterol, ldl, hdl, triglycerides, aspartate aminotransferase (ast), alanine aminotransferase (alt), c-reactive protein (crp), and parameters related to the muscle regeneration and inflammation, such as creatine kinase, lactate dehydrogenase, insulin-like growth factor (igf), tumor necrosis factor alpha (tnf-alpha), interleukin 6 (il-6), monocyte chemoattractant protein 1 (mcp-1). in the second part of the study, the acute effect of consuming each bar after training will be tested. each participant will consume both bars on separate days. the mentioned parameters will be assessed after training and immediately and 3h after bar consumption.

Eligibility criteria:
inclusion criteria: * daily high-intensity physical activity exclusion criteria: * smoking, cardiovascular, neurological, skeletal muscle disease, allergies

Keywords: protein bar physical activity muscle
hormonal replacement therapy and small artery function

Conditions: Menopause

Summary: endothelial dysfunction in resistance arteries in women after the menopause is important for the development of high blood pressure and cardiovascular disease

we aim to study the effects of different hormone replacement therapies (hrt) on the function and morphology of resistance arteries, and to look for their mechanistic basis. we expect that hrt with estrogens or in combination with mpa may benefit the function of resistance arteries and may preserve the morphological integrity of endothelial cells by regulatory actions on the cytoskeleton.

Eligibility criteria:
inclusion criteria: * all women had been amenorrheic for at least 1.5 year. * menopausal status was confirmed by a serum concentration of follicular- stimulating hormone (fsh \> 34 iu/ml) and estradiol (e2 \<50 pmol/l). exclusion criteria: * cigarette smokers and women with: * hypertension * diabetes mellitus * clinical manifestations of arteriosclerosis (coronary heart disease, peripheral artery disease, or cerebrovascular disease) * venous thromboembolic disease * liver disorders * unexplained vaginal bleeding; and * personal or family history of breast cancer were excluded.

Keywords: hormone replacement therapy; endothelial function;
dietary nitrate on blood pressure and cardiovascular disease risk factors

Conditions: Hypertension; Blood Pressure, High

Summary: the project aims to determine the effect of a high-nitrate dietary intervention on blood pressure and markers of vascular function compared to a low-nitrate intervention in people with elevated blood pressure. half of the participants will receive the high-nitrate dehydrated vegetable intervention, while the other half will receive the low-nitrate dehydrated vegetable intervention.this project will advance the current hypothesis on the therapeutic link between dietary nitrate and high blood pressure, and potentially derive impactful recommendations for individuals at risk of hypertension.

diets rich in fruits and in particular, vegetables, reduce blood pressure (bp) and the risk of cardiovascular events. increasingly, attention is being given to high-nitrate containing vegetables, with emerging evidence that it might represent a source of vasoactive nitric oxide. clinical data to date uniformly suggest an acute vasoprotective role of dietary nitrate administration and a bp-lowering effect. whether the vascular effects extend to long-term intake and in individuals with elevated blood pressure is not well known. the investigators hypothesize that consumption of a dietary intervention high in nitrate from vegetable sources will have a greater effect on bp and related vascular parameters than a similar intervention that is low in dietary nitrates.

Eligibility criteria:
inclusion criteria: * bmi 18.5-35 kg/m2 * seated systolic blood pressure ≥130 and \<160 mmhg exclusion criteria: * current use of antihypertensive agents * history of major cardiovascular events in the last 1 year (stroke or myocardial infarction) * stage ii hypertension as per jnc7 criteria (systolic bp/ diastolic bp ≥160/100 mmhg) - angina pectoris * gastrointestinal (i.e. inflammatory bowel disease, celiac), liver or kidney disease * cardiac condition that compromises normal function (e.g. mitral valve disease, heart failure) * serum triglyceride \>4.5mmol/l * major disability or disorder requiring continuous medical attention * planned initiation in antihypertensive therapy * herb or supplement use that may affect primary outcome * consuming \>3 servings of vegetables/day (based on semi-quantitative food frequency questionnaire) * alcohol use \>2 drinks/day * chronic or prescribed use of medications including prescription nsaids, antacids, warfarin, medications affecting no synthesis (ie. sildenafil, organic nitrates, etc) * use of antibiotics within 3-months of the study start * participants should also be willing to refrain from using mouthwash (ie chlorhexidine) for the duration of their participation in the study

Keywords: nitrate vegetables
mutation of the lepr gene at reunion island: involvement in pediatric obesity

Conditions: Obesity, Childhood

Summary: the objective of this study is to estimate the proportion of the recurrent deletion δ6-8 of the lepr gene in the homozygous and heterozygous state in pediatric cases with severe and early ( before the age of 6) obesity (bmi ≥ iotf-30) on reunion island.

the study of the deletion δ6-8 of the lepr gene starts with a saliva sample using a swab in children aged between 3 to 18 years old. the dna from this sample will then be analyzed by the pcr technique. if the deletion of the lepr gene is confirmed in the patient, his adult family members will also be screened using the same procedure.

Eligibility criteria:
inclusion criteria: * patient with early severe and non syndromic obesity (bmi\> iotc-30) (before 6 years old) * adult family members with deletion of lepr gene * informed consent form signed by participants or parents * affiliation to social security scheme exclusion criteria: * patient with syndromic obesity * patient under guardianship or under judicial protection
heparin-based wet suction method in eus fine needle biopsy of solid pancreatic mass

Conditions: Endoscopic Ultrasonography; EUS-FNA; Pancreatic Neoplasms

Summary: the objective of this randomized cross-over trial is to evaluate whether heparin based wet suction technique, compared with dry suction technique, shall present a higher quality tissue core by using quantitative macroscopic and microscopic scale.

background \& aim endoscopic ultrasound guided fine needle biopsy (eus-fnb) is the main tool for tissue acquisition and pathological diagnosis of pancreatic solid mass because of its superior accuracy and lower complication rate compared to ct-guided biopsy. however, the tissue adequacy and diagnostic yield remained unsatisfactory for 2 reasons. first, the conventional dry suction technique (dst) often get small tissue and 3 or more needle passes (i.e. biopsies) are required to obtain enough specimen. second, blood contamination of the acquired tissue interfered with microscopic examination. investigator aim to develop a novel technique to improve tissue acquisition within a fewer needle passes and avoid blood contamination by using heparin-based modified wet suction (h-mwst). methods this study will be a randomized crossover clinical trial. patients with pancreatic solid mass indicated for eus fnb will be enrolled. eus fnb will be done by one experienced endoscopists in national cheng kung university hospital. patients will be randomized in a 1:1 ratio to receive eus fnb with either dry suction technique (dst) or h-mwst first for the initial 2 needle passes, and then crossover to another suction technique for a total of 4 needle passes. the obtained tissue of each needle pass will be sent separately and examined by a pathologist who is unaware of the procedure order. procedure related complications will be recorded. the primary outcome will be the acquired tissue quality quantified comparison. the secondary outcome will be the overall diagnostic yield, the specimen adequacy, and complication rate by each suction technique.

Eligibility criteria:
inclusion criteria: * patients had pancreatic solid mass on ct scan or abdominal echo image exclusion criteria: * anti-platelet and anticoagulant user who cannot stop the medication * recent acute pancreatitis episode (within 2 weeks) * patient with severe cardio-pulmonary dysfunction * pregnant women and adolescent \< 20 years old
analgesia after cesarean section

Conditions: Preeclampsia; Pregnancy

Summary: magnesium sulphate is the first line therapy for the management of preeclampsia and eclampsia in obstetrics. perioperative administration of magnesium sulphate has been proved to be an effective as an analgesic adjuvant. the investigators evaluated the analgesic effect of magnesium in parturients undergoing cesarean section.


Eligibility criteria:
inclusion criteria: * parturients undergoing cesarean section