Kornimate/medical-research-clean huggingface dataset:
safe use of new oral anticoagulants in ablation for atrial fibrillation

Conditions: Atrial Fibrillation

Summary: use of new oral anticoagulants (noac) in patients before and after catheter based pulmonary vein isolation (pvi) is still controversial. experience is reported from consecutive patients ablated with pvi for atrial fibrillation and treated with dabigatran, rivaroxaban, or apixaban from nov 2011 until dec 2014. patients are followed for 3 month after ablation. all complications possible being related to the use of noac are registered.

use of new oral anticoagulants (noac) in patients before and after radiofrequency ablation with pulmonary vein isolation (pvi) is still controversial. experience is reported from consecutive patients ablated with pvi for atrial fibrillation and treated with dabigatran, rivaroxaban, or apixaban from nov 2011 until dec 2014. patients paused their noac treatment for 24 hours before ablation. patients were routinely followed up after 3 months with a standard formular focused on possible adverse events (major bleeding complications or thromboembolic events) to noac treatment. adverse events related to the use of noac were registered during treatment or during 3 months of follow-up.

Eligibility criteria:
inclusion criteria: * symptomatic atrial fibrillation despite pharmacological treatment. exclusion criteria: * none
diagnostic value of compression ultrasound to detect acute compartment syndrome after lower limb revascularisation

Conditions: Compartment Syndrome of Leg

Summary: acute compartment syndrome (acs) after revascularization for acute limb ischemia is a potentially limb-threatening condition and requires urgent fasciotomy. compression ultrasound (cu) is an established method for measuring intravenous pressure in superficial veins and, for example, can determine central venous pressure in critically ill patients. in cadaver studies, compression ultrasound has been proven to correlate with invasive intra compartmental pressure (icp) measurements. this study aims to determine cu's added diagnostic value compared to icp in detecting acs after revascularisation.

acute compartment syndrome (acs) after revascularization for acute limb ischemia is a potentially limb-threatening condition and requires urgent fasciotomy. it occurs when the tissue pressure within a closed muscle compartment exceeds the perfusion pressure and results in muscle and nerve ischemia. if clinically suspected, intra- compartmental pressure (icp) is measured by inserting a needle into the area of acs, usually the anterior tibial muscle compartment, while an attached pressure monitor records the pressure. this invasive diagnostic method is widely used as a standard with a sensitivity of 94% and specificity of 98%. compression ultrasound (cu) is an established method for measuring intravenous pressure in superficial veins and, for example, can determine central venous pressure in critically ill patients. an ultrasound translucent probe measures the pressure applied on the skin surface with the ultrasound transducer. in cadaver studies, compression ultrasound has been proven to correlate with invasive icp measurements. the elasticity ratio (er, compartment diameter with and without external pressure) validated in a recently published animal model has a sensitivity of 94.4% and a specificity of 88.9% to diagnose a compartment syndrome properly. the first results in six trauma patients showed that the er less than 10,5% of the anterior tibial compartment had a sensitivity of 95,8% and a specificity of 87,5% to an appropriate diagnosis of acs. thus, this non-invasive, low-cost, and secure diagnostic technique has not been validated in patients with acs after revascularisation for acute lower limb ischemia yet has the potential to discriminate clinically suspected acs sensitively. this study aims to determine cu's added diagnostic value compared to icp in detecting acs after revascularisation.

Eligibility criteria:
inclusion criteria: * clinical suspicion of acute compartment syndrome after revascularisation of lower limb exclusion criteria: * not fulfilling any of the inclusion criteria * patients refusing to participate

Keywords: compartment syndrome acute limb ischemia intra compartmental pressure compression ultrasound vascular surgery limb revascularisation
efficacy and safety to extend treatment 24 weeks in co-infected hiv-hcv genotype 1 and/or 4

Conditions: HIV Infections; Hepatitis C

Summary: a study concerning viral kinetic with 10 co-infected hiv-hcv patients on treatment with peginterferon alfa-2a + ribavirin o ifn + ribavirin was reported in conference on retroviruses and opportunistic infections 2002 by dr. torriani shown half-life of hcv virions and the viral clearance was larger than mono-infected patients. the doubt is if this difference in viral kinetic of hiv-hcv co-infected patients versus mono-infected is related with the loss of profited on treatment. in the apricot trial patients genotype 2/3 were treated for 48 weeks and the relapse rates was only 2%. the present study want to evaluate is the treatment extent for 24 weeks more in patients genotype 1 and/or 4 will be improve the percentage of patients with viral clearance at the end of the follow-up period, to prevent relapsed in patients with response at the end of treatment. patients will be randomized to received 180 µg/week of peginterferon alfa-2a + 1000-1200 mg/day of ribavirin during 24 weeks more or control.

to evaluate efficacy of extend treatment during 24 weeks more in co-infected hiv-hcv patients with genotype 1 and/or 4 who at 44 week of treatment with peginterferón alfa-2a in combination with ribavirin have rna-hcv undetectable.

Eligibility criteria:
inclusion criteria: * patients on treatment with peginterferon alfa-2a (180 µg/week) in combination with ribavirin (1000-1200 mg/day) who are rna-hcv undetectable at 44 week * rna-hcv positive at 48 week before study and genotype 1 or 4. * hiv-1 positive: elisa y western-blot. * stable status of hiv-1 infection in the opinion of the investigator, (patients who are not expected to progress during the study). * negative urine or blood pregnancy test (for women of childbearing potential) documented within the 24-hour period prior to the first dose of study drug. additionally, all fertile males and females must be using two forms of effective contraception during treatment and during the 6 months after treatment end. this may include, but is not limited to, using birth control pills, iuds, condoms, diaphragms, or implants, being surgically sterilized, or being in a post-menopausal state. * willingness to give written informed consent and willingness to participate to and comply with the study. exclusion criteria: * patients with rna-hcv detectable after 44 weeks of treatment with peginterferon alfa-2a (180 µg/week) in combination with ribavirin (1000-1200 mg/day). * patients with other treatment for chronic hepatitis, different which of inclusion criteria is described. * more of tree weeks from the end of treatment with peginterferon alfa-2a (180 µg/week) in combination with ribavirin (1000-1200 mg/day) to the inclusion in "extrados" trial.

Keywords: chronic hepatitis c co-infection extend treatment co-infected hiv-hcv
electroacupuncture anesthesia for nasal sinus surgery and mammaplasty

Conditions: Therapeutic (Nonsurgical) and Rehabilitative Anesthesiology Devices Associated With Adverse Incidents

Summary: the purpose of this study is to verify the intraoperative analgesia of electroacupuncture in patients undergoing selective nasal sinus surgery and mammaplasty.

acupuncture therapy has been proved helpful in the patients suffering from various pain problems. and it is reported to be able to reduce the intraoperative anesthetic requirement. however, so far there is few evidence from randomized controlled studies to confirm the assistant anesthetic effect of acupuncture. electroacupuncture (ea) is a modern non-invasive technique of traditional acupuncture. compared to traditional acupuncture, ea is more practicable, more easily to be accepted by patients and operated by physicians. nasal sinus surgery and mammaplasty, especially breast augmentation, mostly belong to the scope of day surgeries, which demand a rapid, smooth recovery from anesthesia with minimum adverse side effects (e.g.: pain, ponv, etc).

Eligibility criteria:
inclusion criteria: * selective nasal sinus surgery * selective mammaplasty * patients who accept the follow-up and sign the informed consent * asa 1\~2 exclusion criteria: * emergent surgery * pregnant or breast-feeding women * coagulopathy * history of gastrointestinal ulcer * liver or renal dysfunction * enrollment in other clinical trials at the same time not reaching the primary endpoint and probably interference the present trial

Keywords: electroacupuncture analgesia anesthesia nasal septoplasty mammaplasty
1064-nm q-switched nd:yag laser and intradermal tranexamic acid for melasma

Conditions: Melasma

Summary: background: melasma is a chronic, often relapsing skin disorder, with poor long-term results from all current therapies.q switched 1064nm nd:yag laser and intradermal tranexamic acid both showed efficacy on the treatment of melasma. however, no combination therapy of both be reported. objectives: to compare the efficacy of low influence q switched 1064nm nd:yag laser and low influence q switched 1064nm nd:yag laser combined with intradermal tranexamic acid injection for melasma.

methods: twenty patients with melasma were included in a randomized controlled observer-blinded study with split-face design. each side of the face was randomly allocated to either six session at two-week interval of low influence 1064 nd:yag laser (6 mm spot size, energy fluence 1.2 - 1.4 j/cm 2 at 10 hz) or low influence 1064nm nd:yag laser combined with intradermal tranexamic acid injection.complication improvement of melasma was assessed by melasma area severity index (masi),physician's global assessment (phga), melasqol scale, patient's global assessment (pga), and patient's satisfaction at baseline,6th week,10th week after first treatment and 3 months, and 6 months after last treatment.

Eligibility criteria:
inclusion criteria: * patients \> 20 years old with refractory melasma to topical treatment exclusion criteria: * history of keloid, active eczema, active acne in the face, history of facial eczema, photosensitivity, use of isotretinoin in the past 6 months, pregnancy, and high exposure to sunlight or uv light (uva or uvb)
endobronchial diagnosis of lymphoma

Conditions: Lymphoma

Summary: the present study aimed to assess the diagnostic performance of ultrasound-guided endobronchial intra-nodal miniforceps biopsy (ebus-mfb) in the diagnosis of "de novo" mediastinal lymphoma.

every patients will be sampled using both ebus-mfb and the standard of care ebus-tbna (transbronchial needle aspiration). it is a monocentric investigation. pathologist will not know the way of sampling while analysing the samples

Eligibility criteria:
inclusion criteria: * pathological mediastinal nodes within reach of ebus sampling on ct-scan. * lymphoma suspicion by a senior clinical hematologist * affiliated to the french public health care insurance exclusion criteria: * peripherical pathological lymph nodes reachable without general anesthesia * antithrombotic medication that cannot be stopped le time of the procedure. * unstable respiratory status * history of lymphoma * latex or xylocaine allergia

Keywords: ebus endobronchial ultrasound-guided ebus-mfb intra-nodal miniforceps biopsy ebus-transbronchial forceps biopsy
effects of constraints induced movement therapy versus mirror therapy in children with hemiplegic cerebral palsy

Conditions: Cerebral Palsy; Hemiplegic Cerebral Palsy

Summary: the aim of this study is to find effects of constraints induced movement therapy (cimt) versus mirror therapy (mt) on hand dexterity and grip strength in children with hemiplegic cerebral palsy.

although quite number of research has been done on effects of cimt and mirror therapy but most of the studies included stroke population. there was no literature on comparative effect of both cimt and mirror therapy in children with hemiplegic cerebral palsy. this study will be covering specifically cerebral palsy children to have better treatment techniques to be introduced in therapeutic programs of hemiplegic cerebral palsy children.

Eligibility criteria:
inclusion criteria: * children of age range 9-14 year * children with diagnosed hemiplegic cerebral palsy * children who can perform active extension of affected wrist and more than * two fingers at an angle of more than 10 degrees * active abduction of affected thumb at an angle of 10 degrees * children who can respond to simple communication- exclusion criteria: * children with uncontrolled seizures * botulinum toxin injections or orthopedic surgery in the upper or lower * extremities within the previous 12 months or planned within the study period * children with depression who were unable to cooperate in treatment * children who are unable to perform active task training

Keywords: cerebral palsy constraints induced movement therapy mirror therapy
inflammatory biomarkers and brain metabolites, a study based on magnetic resonance spectroscopy

Conditions: Depression

Summary: suicidal behaviors (sb) are a major health problem in france : 10 000 suicides and 220 000 suicide attempts every year. sb management is therefore a major public health issue. evidence associated dysregulation of the serotonergic system and the hypothalamic-pituitary-adrenal axis to vulnerability to sb. recent data point to linke these abnormalities with neuroinflammatory clues, glutamatergic function and neuronal plasticity. there is a need to better understand the physiopathology and develop diagnostic and therapeutic tools in sb. the investigators hypothesize that increased peripheral biomarkers of inflammation would correlate to a disturbance of the cerebral metabolites, such as glutamate and naa, especially in suicidal patients. our aim is to compare rates of cerebral metabolites, in particular the complex glutamine/glutamate, in cerebral areas involved in suicidal vulnerability (the anterior cingulate cortex and the orbito-frontal cortex) between person with unipolar disorder with and without suicidal attempt.

69 patients : 23 with suicidal thoughts and attempt, 23 with suicidal thoughts without attempt and 23 healthy volunteers. 2 visits : * inclusion visit (v0) : (day 1) o clinical interview : self and hetero assessment questionnaire * visit v1 (as soon as possible, day 1 if available) : * mri (spectroscopy)

Eligibility criteria:
non-specific inclusion criteria: * having signed informed consent * able to understand nature, aims and methodology of the study specific inclusion criteria : * suicidal patient with suicide attempt : * persistent depressive disorder according to the diagnostic and statistical manual of mental disorders - v (dsm-v) criteria, and evaluated by the mini international neuropsychiatric interview (mini) * hamilton depression scale \> 7 * suicide attempt \< 1 week * suicidal patient without suicide attempt : * persistent depressive disorder according to the diagnostic and statistical manual of mental disorders - v (dsm-v) criteria, and evaluated by the mini international neuropsychiatric interview (mini) * hamilton depression scale \> 7 * no history of suicide attempt * healthy volunteers : * no psychiatric history * no history of suicide attempt exclusion criteria: * actual somatic, neurological or inflammatory pathology (c-reactive protein \> 10mg/l) * traumatic brain injury with loss of consciousness * antibiotic treatment or anti-inflammatory treatment * actual toxic abuse according to dsm-v (except tobacco and alcohol) * actual or passed history of psychotic disorder * patient on protective measures (guardianship or trusteeship) * deprived of liberty subject (judicial or administrative decision) * pregnant women or breastfeeding * contraindications to mri scan

Keywords: psychiatry suicidal behaviour cerebral metabolites mri inflammatory markers
teeth and jaw misalignment in patients suffering from congenital fourth cranial nerve palsy

Conditions: Fourth Cranial Nerve Palsy

Summary: patients suffering from congenital fourth cranial nerve palsy may have misalignment of jaws as well as teeth due to head tilt in childhood.

measurement of teeth and jaw parameters in patients suffering from congenital fourth cranial nerve palsy compared to patients without fourth cranial nerve palsy.

Eligibility criteria:
inclusion criteria: * unilateral congenital fourth nerve palsy * natural teeth occlusion * age \> 18 years exclusion criteria: * bilateral fourth nerve palsy * no natural teeth occlusion

Keywords: teeth position jaw alignment
cardiovascular risk assessment study in lupus erythemathodes (castle)

Conditions: Systemic Lupus Erythematosus

Summary: the key of this prospective study is to identify a potentially increased cardiovascular risk in patients with systemic lupus erythematodes, with and without renal affection. three groups of patients will be compared.

key of this prospective study is to identify a potentially increased cardiovascular risk in patients with systemic lupus erythematodes, with and without renal affection. three group of patients will be compared as followed. first group are patients with known systemic lupus erythematodes without renal affection, second group are patients with known systemic lupus erythematodes with renal affection and the third group are patients with a non-autoimmun chronic kidney disease

Eligibility criteria:
inclusion criteria: * patients with systemic lupus erythematosus exclusion criteria: * patients without systemic lupus erythematosus

Keywords: lupus erythematosus cardiovascular risk
parkinson's disease: enhancing physical therapy with brain stimulation for treating postural instability.

Conditions: Parkinson Disease

Summary: this trial aims to understand the mechanism and to test whether transcranial direct current stimulation (tdcs) combined with transcranial ultrasound (tus) (tdcs+tus) combined with physical therapy (pt) will induce significant therapeutic effects in postural instability in parkinson's disease (pt) patients. the investigators designed a double-blinded, placebo controlled, randomized study to investigate the effects of 2 weeks of tdcs+tus on postural instability in pd patients receiving pt. (followed by biweekly sessions for 2 more weeks in phase ii)

current treatments for parkinson's disease (pd), including pharmacological (levodopa) and surgical (dbs) methods, have limited impact on postural instability. physical therapy (pt) for pd is becoming increasingly used as a means to induce benefits on patient balance. however, limits in efficacy and consistency still exist. in this study, the investigators will test the effects of tdcs+tus combined with pt on postural instability of pd patients.

Eligibility criteria:
inclusion criteria: 1. diagnosis of "probable" or "possible" pd, as defined by the current clinical criteria (gelb d, oliver e, gilman s. diagnostic criteria for parkinson's disease. arch neurol.1999;56:33-39) as confirmed by co-investigator neurologist, or confirmation via medical records or a letter from patient physician; 2. complaints about balance impairment or postural instability due to pd (self-report); 3. age from 40 to 90 years old; 4. taking stable medications for pd for at least 30 days. exclusion criteria: 1. features suggestive of other causes of parkinsonism/parkinson's-plus syndromes; 2. history of deep brain stimulation or brain ablation surgeries, malignant mass brain lesions; 3. history of schizophrenia, bipolar illness; history of alcohol/drug abuse within the past 6 months; 4. need for rapid clinical response due to conditions such as initiation, psychosis, or suicidality; 5. contraindications to transcranial brain stimulation or tus, i.e. metal in the head, implanted brain medical devices, etc.; 6. unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure, uncompensated pulmonary disease, or chronic obstructive pulmonary disease); 7. pregnancy. 8. epilepsy or disorders that significantly increase likelihood of seizures including: severe traumatic brain injury, congenital birth defects leading to seizures, brain tumor, metabolic disorders associated with seizures, intracranial or subarachnoid hemorrhage, and nonlacunar strokes. 9. recent (\<= 2 months) or planned enrollment in an additional physician prescribed physical therapy program during their time in the trial. 10. presence of another disorder that might have a significant impact on balance (as assessed by a co-investigator neurologist). 11. bed or wheelchair-bound
measuring adherence to topical therapy in children with atopic dermatitis and the impact of a return visit

Conditions: Atopic Dermatitis

Summary: the purpose of this research study is to better understand how the study drug works when people use it to treat atopic dermatitis.

to evaluate adherence to topical therapy using adherence data collected by the mems cap (medication electronic monitoring system) in pediatric patients with atopic dermatitis (ad) and the impact of a return visit.

Eligibility criteria:
inclusion criteria: 1. male or female subjects age 2-15. 2. stable or worsening atopic dermatitis affecting 5% or greater body surface area. face and genital areas can be included in the body surface area determination and treatment area. 3. the ability and willingness to follow all study procedures, attend all scheduled visits, and successfully complete the study. 4. the ability to understand and sign a written informed consent/assent form, which must be obtained prior to treatment. exclusion criteria: 1. known allergy to tacrolimus or to any component of the formulations. 2. the use of systemic therapy for atopic dermatitis within the past 4 weeks. 3. use of prescription topical therapy for atopic dermatitis (e.g., corticosteroids or retinoids) within the past 2 weeks. 4. use of any investigational therapy within the past 4 weeks. 5. pregnant females, females who are breast feeding, or females of childbearing potential who are not practicing an acceptable method of birth control (abstinence, birth control pill/patch, barrier with spermicidal jelly, iud, etc.), as determined by the investigator. acceptable contraception must be used during the entire study. a pregnancy test will be performed on females of childbearing potential at baseline and at week 4. 6. any other condition which, in the judgment of the investigator, would put the subject at unacceptable risk for participation in the study.

Keywords: atopic dermatitis eczema