Kornimate/medical-research-clean huggingface dataset:
ketone supplementation, glycogen replenishment and time trial performance following glycogen lowering exercise

Conditions: Ketonemia; Exercise Performance; Ketosis

Summary: 20 healthy trained males will volunteer to participate in this study. there will be 2 treatments: carbohydrate- ketone supplementation and carbohydrate alone. the purpose of this study is to evaluate the effect of glucose-ketone supplementation on a 20 km cycling time trial with a 2-hour feeding during a 4-hour recovery period following glycogen depleting exercise.

carbohydrates (starches \& sugars) are important muscle fuel for exercise at moderate to high intensities. low glycogen content (stored form of carbohydrates in the body) is associated with fatigue. thus, greater initial glycogen content has been associated with better performance not only in high intensity intermittent sports, but also in prolonged endurance sports. dose-response studies have determined that ingestion of 1.2 g·kg-1·h-1 of cho is the appropriate acute recovery dose to optimize glycogen repletion, with no apparent benefit at higher doses. protein in combination with cho has also been proposed to enhance glycogen resynthesis when 1 part protein is provided with \~4 parts cho. both strategies, optimal cho intake and cho in combination with protein for glycogen resynthesis, have resulted in better exercise performance a few hours after a depleting exercise bout. a recent study provided athletes with ketone esters in a drink after glycogen depleting exercise and found that in the presence of high glucose availability, ketone esters increased glycogen stores by 50% compared to a no ketone, high carbohydrate treatment. however, the authors of this study provided a large quantity of carbohydrates intravenously to maintain blood glucose at 10mm/l. consequently, it is unknown whether or not ingesting glucose at the optimal dosage would have the same effect. furthermore, it is unclear whether or not this difference would translate into improved performance in efforts of more moderate duration. therefore, the purpose of this study is to assess the effect of glucose-ketone supplementation on a 20 km cycling time trial with a 2-hour feeding during a 4-hour recovery period following glycogen depleting exercise.

Eligibility criteria:
inclusion criteria: * in order to be eligible to participate in this study you must be a healthy male or female exercise trained individual (at least 1y training experience - at least 3x week), aged 18-40 years. exclusion criteria: * have not involved been involved in regular exercise (at least 3x week for at least the past year) * have symptoms or take medication for respiratory, cardiovascular, metabolic, neuromuscular disease * use any medications with side effects of dizziness, lack of motor control, or slowed reaction time * are taking part in another research study * for women, if you are pregnant or become pregnant during the study. * have a history of concussion/head injuries. * have an excessive alcohol intake (\>2 drinks/day) * are a smoker

Keywords: ketones glycogen replenishment exercise performance
cutaneous microbiota evolution in icu patients with cvc (icmc)

Conditions: Dysbiosis; Catheter-Related Infections

Summary: intensive care unit (icu) patients are exposed to catheter-related infections with an important morbidity. catheter colonization is constant but infection is not. cutaneous dysbiosis could be the missing link. our study aims to evaluate the evolution of cutaneous microbiota in icu patients with a central venous catheter in place, through metagenomics. our main objective is to evaluate the evolution of alpha-diversity, quantified by intra-patient variation of shannon diversity index (a diversity index used in bacterial metagenomics).

central venous catheters (cvcs) are necessary in up to 60% of icu patients, representing a risk of catheter-related infections with high morbidity and mortality. catheter colonization originating mostly from the skin is constant, but infection is not. dysbiosis is known to be associated with pathological states and infection, for example post-antibiotic c. difficile diarrheas, or atopic dermatitis, in which flares are associated with dysbiosis and s. aureus predominance. cutanous dysbiosis could be the missing link between catheter colonization and infection. our hypothesis is that under the influence of multiple icu factors (stress, antibiotic administration, local dysinfection procedures), cutaneous dybiosis appears in icu patients with a central venous catheter. all adult icu patients with an indication for cvc placement will be included over a 6 months period. skin swabbing will be performed on cvc insertion site before cvc placement (baseline), and then every 3 days (or when dressing is changed) while cvc is in place, then at icu discharge. bacterial metagenomics using bacterial dna extraction, 16s pcr amplification and nanopore sequencing will allow for description of cutaneous microbiota and diversity evaluation through shannon index. evolution of alpha-diversity will be evaluated through time-series data analysis: comparison of shannon index at various time points with baseline shanonn index (before cvc placement). standard microbiologic culture of skin swabbing will be performed. general patient characteristics and informations relative to cvc infection and treatment will be collected. this study will have no impact on patient management. category 3 non-interventional human person research (riph 3)

Eligibility criteria:
inclusion criteria: - adult hospitalized in icu at the cayenne hospital center in whom the installation of a cvc is indicated exclusion criteria: * patient under 18 years of age * patient or trusted person or family or relative objecting to participation in the study (refusal) * patient under judicial safeguard or under any other protective regime (guardianship or curatorship) * patient with cutaneous lesions (infection, burn) near the cutaneous insertion site of the cvc

Keywords: microbiota cutaneous microbiota healthcare associated infection catheter-related infections
preoperative inflammatory status and postoperative acute kidney injury

Conditions: Postoperative Acute Kidney Injury

Summary: acute kidney injury (aki) is a common complication during the early postoperative period after noncardiac surgery. patients with aki are at an increased risk of developing chronic kidney disease, prolonging hospitalization, and experiencing higher rates of morbidity and mortality. identifying preoperative risk factors for postoperative aki can significantly contribute to the development of preventive strategies and improved perioperative care in this vulnerable patient population. the goal of this retrospective study is to investigate the predictive value of preoperative inflammatory status, as measured by complete blood count-derived inflammatory markers, such as the neutrophil-to-lymphocyte ratio (nlr), platelet-to-lymphocyte ratio (plr), monocyte-to-lymphocyte ratio (mlr), derived neutrophil-to-lymphocyte ratio (dnlr), neutrophil-to-lymphocyte\*platelet ratio (nlpr), systemic immune-inflammatory index (sii), systemic inflammatory response index (siri), and aggregate index of systemic inflammation (aisi), on postoperative aki in elderly patients undergoing non-cardiac surgery.


Eligibility criteria:
inclusion criteria: 1. aged ≥ 65 years. 2. general, gynaecological, neurosurgery, orthopaedic, or thoracic surgery. 3. surgery duration lasting longer than one hour. exclusion criteria: 1. patients with an american society of anesthesiologists (asa) physical status v. 2. those with concurrent cardiac, vascular, transplant or urological surgeries. 3. those with end-stage renal disease (i.e. a glomerular filtration rate of 15 ml/min/1.73 m2 or receiving haemodialysis) or a history of kidney transplantation.. 4. those did not have sufficient data required for calculation for inflammatory markers or aki evaluation.
detecting early onset pre-eclampsia and use of placental growth factor (plgf) for marker of trisomy 21

Conditions: Pregnancy

Summary: this is a study for the evaluation of the benefits of 1 st trimester risk markers in detecting early onset pre-eclampsia and the use of the placental growth factor(pigf) as a potential marker for trisomy 21 and other aneuploidies. aim of this prospective nonprofit study is to analyze the benefits of early onset pre eclampsia risk assessment in the 1st trimester (measuring biochemical markers \[pigf\], blood pressure and doppler ultrasound), and how the results can permit to modify or influence the course of the preeclampsia during the pregnancy. the investigators will also evaluate the potential use of the pigf as a marker to improve the prenatal screening with the currently used nuchal translucency, serum pregnancy-associated plasma protein a (papp-a) and free beta subunit of human chorionic gonadotropin (fbhcg) parameters.


Eligibility criteria:
inclusion criteria: * singleton pregnancy * nulliparous pregnancy * gestation age between 6.0-13.6 weeks by last menstrual period verified by ultrasound * blood sample provided at gestational age 6.0-13.6 weeks * informed consent exclusion criteria: * multi-fetal pregnancy * primiparous or multiparous pregnancy * mental retardation or other mental disorders that impose doubts regarding the true patient's willingness to participate in the study * gestation age below 6.0 or above 13.6 weeks by last menstrual period verified by ultrasound. * lack of blood sample at the specified enrollment period * known major fetal anomaly or fetal demise * lack of demographic data
the role of cognitive function and electroencephalography on acute and chronic pain after surgery

Conditions: Acute Pain; Chronic Pain; Thoracic Surgery; Electroencephalography; Brain Mechanism

Summary: the project will apply the methods of clinical observation experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after surgery. (2) to collect the resting-state electroencephalography (eeg) preoperatively, and to assess the role of eeg index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after surgery.

patients after surgery are liable to suffer from moderate to severe acute pain and refractory chronic pain, which would lead to serious somatic and psychological suffering. its successful treatment is a great challenge for pain physicians. to date, the mechanism of pain chronification after surgery remains unclear. further, it is still lack of efficient preventive and therapeutic measures for this chronic pain. the project will apply the methods of clinical observation and animal experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after thoracic surgery. (2) to collect the resting-state electroencephalography (eeg) preoperatively, and to assess the role of eeg index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after thoracic surgery. the project will be able to determine the relationships between the degree of recovery of early postoperative cognitive function, as well as preoperative resting-state eeg indices and postoperative acute pain and chronic pain, and clarify the neural mechanism of acute pain and chronic pain after surgery. the expected outcomes of this study can contribute to early identification of the patients who are liable to develop into acute pain and chronic pain after surgery, and give them reasonable intervention in time, and provide effective solutions for the acute pain and chronic pain after surgery.

Eligibility criteria:
inclusion criteria: * surgery were planned to be performed under general anesthesia * educational attainment beyond high school * require postoperative analgesia and sign the informed consent exclusion criteria: * with mental illness or a family history of mental illness * patients with cerebrovascular diseases or cerebrovascular accidents * previous head trauma history or craniotomy * using central analgesics, opioids addiction * with a history of alcoholism * do not understand the numerical rating scale(nrs) score and can not use patient-controlled analgesia(pca）
effects of a multi-strain oral probiotic on the vaginal microbiota composition in healthy women and women with endometriosis

Conditions: Endometriosis; Bacterial Vaginosis; Healthy Volunteer

Summary: endometriosis is a chronic inflammatory disease affecting approximately 10-15% of reproductive age women, and, in recent years, an association between this pathology and dysbiosis, either involving the gut or the genital microbiota, has been hypothesized. therefore, the aim of the study is to investigate the etiopathogenetic role of cervico-vaginal microbiota, and its relationship to the gut microbiota, in women with endometriosis. furthermore, the effects of a multi-strain oral probiotic formulation will be evaluated on the composition of the genital microbiota in healthy women and patients with endometriosis.


Eligibility criteria:
inclusion criteria: * age between 20 and 40 years old; * clinical diagnosis of endometriosis via gynecological examination and transvaginal ultrasound (tvus); * genital healthy condition as confirmed via gynecological examination. exclusion criteria: * pre-menarche or menopause status; * diabetes, neoplastic diseases, urinary or genital infections in the past 6 months * bowel and/or liver disorders; * current treatment with oral contraceptive or progestins, prokinetics, antacids or proton pump in-hibitors; * sexual activity in the week before sampling; * recent or current antibiotic treatment (oral or topical); * the use of probiotics and/or prebiotics for three months before the enrolment.

Keywords: gut microbiota vaginal microbiota probiotic endometriosis bacterial vaginosis 16s metagenomic
study of the correlation between muscle oxygenation and motor function in children with neuromuscular disease.

Conditions: Neuromuscular Diseases in Infants; Neuromuscular Diseases in Children

Summary: preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls. up to date, pediatric data are lacking. the study aims at demonstrating if a correlation exists between the motor deficiency and the muscular deoxygenation in children suffering from neuromuscular disorders.

preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls, as it was demonstrated in becker muscular dystrophy patients and fascioscapulo humeral muscular dystrophy. moreover, the deoxygenation kinetics was positively correlated to the functional status and the muscular deficiency severity. however, no pediatric study has been conducted on this topic up to date. the aim of the study is to determine if a correlation exists in children suffering from neuromuscular diseases: * between muscular oxygenation and the percentage of the 6 minutes walking test performed in the routine medical care * between muscular oxygenation and the total and d1 motor function measure value

Eligibility criteria:
inclusion criteria: * children from 6 to 18 years-old suffering from a neuromuscular disorder * able to walk, with or without help exclusion criteria: * hypoxia secondary to heart or lung disease * visual impairment (\<5/10) * parents refusal concerning data storage
preoperative administration of lugols solution in toxic thyroid diseases (td): a prospective study

Conditions: Toxic; Thyroid

Summary: lugol's solution and other preparations containing iodide have been used as an adjuvant treatment in patients with toxic disease planned for thyroidectomy. however, no conclusive evidence supporting the benefits of preoperative treatment with ls for patients with toxic goiters. this trial aims to provide new insights into future recommendations.


Eligibility criteria:
inclusion criteria: * patients ≥18 years of age * toxic thyroid disease, treated with antithyroid drugs, euthyroid and proposed for total thyroidectomy * written informed consent exclusion criteria: * prior thyroid or parathyroid surgery, * hyperparathyroidism that requires associated parathyroidectomy, * thyroid cancer that requires adding a lymph node dissection, * iodine allergy, * consumption of lithium or amiodarone, * medically unfit patients (asa-iv), * breastfeeding women, * preoperative vocal cord palsy and * planned endoscopic, video-assisted or remote access surgery.
observational prospective turkish inception cohort of uveitis and spondyloarthritis

Conditions: Spondylarthritis; Uveitis, Anterior

Summary: spondyloarthritis (spa) encompasses a group of inflammatory rheumatic diseases characterized by axial and/or peripheral arthritis, along with extra-articular manifestations such as enthesitis, dactylitis, uveitis, and skin lesions. axial spondyloarthritis (axspa), the hallmark of which is chronic sacroiliitis, can progress to vertebral fusion ("bamboo spine") in advanced cases. the prevalence of axspa varies globally, ranging from 0.1% to 1.4%, with a higher incidence in men and a typical onset in the second or third decades of life. diagnostic approaches include imaging techniques such as sacroiliac mri and radiographs, alongside clinical criteria like inflammatory back pain, nsaid responsiveness, peripheral arthritis, and hla-b27 positivity. disease management primarily involves nsaids, with biologics used for refractory cases, and disease activity is monitored using indices such as basdai and asdas. acute anterior uveitis (aau) is the most common extra-articular manifestation of spa, particularly associated with hla-b27 positivity. it often presents unilaterally with redness, pain, and photophobia but can lead to severe complications if inadequately treated. around 50% of patients with hla-b27-positive aau have underlying spa, and the prevalence of uveitis increases with longer disease duration. while the link between spa and aau is well-established, further research is needed to determine optimal systemic treatment and follow-up protocols. this study aims to assess the prevalence and clinical characteristics of spa in patients presenting with aau at ophthalmology clinics.


Eligibility criteria:
inclusion criteria: * patients with uveitis exclusion criteria: * patients diagnosed spondyloarthiritis before from the uveitis attack * patients with infectious uveitis

Keywords: spondylarthritis, acute anterior uveitis, inflammatory back pain, hla-b27
evaluation of early changes visible to the diffusion mri in response to two years of treatment with tysabri in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: through this phase iv study, multicenter prospective exploratory, uncontrolled, the investigators propose to identify mri predictive factors of treatment response, using diffusion mri sequences, in addition to conventional sequences. the primary objective is to study the links between changes on mri diffusion and response to treatment with tysabri to 2 years. the secondary objective is to compare the evolution of diffusion mri data with the volumetric mri data.


Eligibility criteria:
inclusion criteria: * major patient * patient with relapsing remitting multiple sclerosis and eligible for treatment with tysabri * patient affiliated to a social security scheme * patient who signed informed consent * patient who have been informed of the results of the prior medical examination exclusion criteria: * patient not currently eligible for treatment with tysabri * contraindication to mri scanning * unability to provide informed consent (subject in an emergency situation, difficulties in understanding , ...) * patient under judicial protection * patient under guardianship or curatorship * pregnancy (women of childbearing age in the absence of effective contraception) * breastfeeding
preventing excessive gestational weight gain via short mobile messages in wic

Conditions: Gestational Weight Gain

Summary: the objective of this trial was to investigate the effect of educational short message service (sms), or text messages, on gestational weight gain (gwg) in a low-income population.


Eligibility criteria:
inclusion criteria: * 15-20 weeks gestational age and 18 years of age or older at time of recruitment * body mass index (bmi) of 25-45 kg/m2 in the first trimester * possession of a cellular phone with the ability to receive text messages without a charge exclusion criteria: * conditions requiring a special diet * multiparous pregnancies * unable to consent to participate * unwilling to be randomized
obesity, inflammation and oxidative stress

Conditions: C-reactive Protein; Inflammation; Obesity; Oxidative Stress

Summary: the purpose of this study is to determine whether or not vitamin c (1000 mg/day) can reduce markers of inflammation, especially c-reactive protein (crp), in obese persons with baseline crp greater than 1 mg/dl.

the long-term objective of this project is to identify nutritional factors that can reduce the inflammatory component of obesity. therapies to minimize obesity-related comorbidities are needed, and targeting inflammation may help slow the progression of obesity towards cardiovascular disease and insulin resistance. adipose tissue is a source of inflammatory cytokines, and obesity is now viewed as a chronic, low-grade inflammatory state. inflammation itself is a contributor to the chronic diseases associated with obesity. c-reactive protein (crp) is a key marker of inflammation, and as a downstream marker it provides functional integration of upstream cytokine activation associated with inflammation. we have previously shown that vitamin c, but not vitamin e, reduces crp in active and passive smokers and in nonsmokers. the reduction is seen primarily in persons with crp ≥1.0 mg/l, the cdc threshold for elevated cardiovascular disease risk. we also found that 75% of obese nonsmokers had crp ≥1.0 mg/l. the important observation of reduction in elevated crp by vitamin c now needs to be confirmed in a rigorous study with adequate sample size, to permit justifiable conclusions about the potential usefulness of this agent in reducing inflammation in the obese. we will conduct a placebo-controlled, randomized trial in 552 healthy obese individuals with moderate crp elevations (crp ≥1.0 mg/l). participants will be randomized to either 1000 mg/day vitamin c or placebo for a period of 2 months. we will also characterize the pathways through which this effect takes place by measuring cytokines and oxidative stress. this project is important because if our previous finding is confirmed in this population, it could offer a low-cost alternative to use of statins to reduce inflammation in persons without other risk factors.

Eligibility criteria:
inclusion criteria: * bmi ≥ 30 * hscrp ≥ 1 mg/l * age 18+ * member of kaiser permanente health plan of northern california exclusion criteria: * smoker * unwilling to discontinue vitamin supplements for study duration * unwilling/unable to use acetaminophen in place of otc anti-inflammatory medications * use of certain medications * history of certain medical conditions

Keywords: randomized controlled trial primary prevention vitamin c antioxidants c-reactive protein inflammation anti-inflammatory agents obesity