Kornimate/medical-research-clean huggingface dataset:
effects of exercise on depression symptoms, physical function, and quality of life in community-dwelling elderly

Conditions: Healthy Elderly

Summary: the purpose of this study was to investigate the effects of 8-week exercise training on depression symptoms, physical functions, and quality of life in the community-dwelling elderly.


Eligibility criteria:
inclusion criteria: * elderly subjects living in the community aged 65 years or older, sedentary lifestyle exclusion criteria: * cancer, major neuromuscular disease, respiratory or cardiovascular disease which might affect exercise * post myocardial infarction or major surgery in the previous year * psychological disease

Keywords: depression physical function quality of life
radiographic evaluation of bone height gain with dental implant placed simultaneously with closed sinus lifting using hydraulic lift technique versus summers' osteotome technique in posterior edentulous maxilla (rct)

Conditions: Evaluations, Diagnostic Self

Summary: radiographic evaluation of bone height gain with dental implant placed simultaneously with closed sinus lifting using hydraulic lift technique versus summers' osteotome technique in posterior edentulous maxilla (rct)

evaluation will be done on the amount of bone height gain radiographically (using both panorama and cbct) after placement of the dental implant simultaneously with closed sinus lifting using hydraulic lift technique versus summers' osteotome technique in patients with posterior edentulous maxilla (randomized clinical trial)

Eligibility criteria:
inclusion criteria: * edentulous patients in the maxillary posterior region . * patients in need to fixed restorations in posterior region . * patients with a healthy systemic conditions.(apparently medically free) * patients with adequate inter-arch space for placement of the prosthetic part of the implant . * patients who had approximately 5-8 mm of available bone height between crest of bone and floor of sinus * both sexes. * patients with good oral hygiene * patients more than 20 years old * cooperative and motivated patients exclusion criteria: * patients with local pathological defects related to posterior maxilla . * heavy smokers. * abnormal habits that may alter results such as alcoholism or parafuctional habits . * patients with systemic diseases that may affect normal healing. * patients with psychiatric problem * patients with history of recent radiation therapy to the head and neck area . * patients with aggressive periodontitis .
tacrolimus, sirolimus and methotrexate as graft versus host disease prophylaxis after blood stem cell transplantation

Conditions: Graft Versus Host Disease; Hematologic Malignancies

Summary: the purpose of this study is to determine if the incidence of graft vs. host disease (gvhd) after non-myeloablative transplantation can be reduced by using a combination of three immune suppressive medication; sirolimus, tacrolimus and methotrexate.

* patients will be admitted to the hospital and receive chemotherapy and stem cell transplant(sct). the total duration of hospitalization for the procedure is approximately 8 days. once admitted the patient will receive fludarabine daily for 4 days, busulfex once daily for 4 days. two days after chemotherapy has ended, the patient will receive the infusion of donor cells. * just prior to the transplant and following the transplant, patients will receive sirolimus (orally), tacrolimus (orally) and low doses of methotrexate (chemotherapy). methotrexate will be given on days 1,3 and 6 after transplant. * sirolimus will be tapered beginning week 9 after transplant if there is no evidence of gvhd and will be eliminated on week 26 if clinically feasible. * tacrolimus will be tapered beginning week 9 after transplant if there is no evidence of gvhd and will be eliminated on week 26 if clinically feasible. * patients will also receive medication to help prevent possible infection. * after stem cell infusion, patients will be examined and have blood tests weekly for 1 month. at the 1 month visit, a bone marrow biopsy will performed looking for evidence of donor cells in the bone marrow. after the one month evaluation the patient will be examined every 2 weeks and a repeat bone marrow performed 3-4 months after transplant.

Eligibility criteria:
inclusion criteria: * patients with hematologic malignancies who are at a high risk of complications after conventional transplantation. * donors (both related and unrelated) who are identical at 6 hla loci. * age greater than 18 * ecog performance status 0-2 * life expectancy of greater than 100 days. exclusion criteria: * pregnancy * evidence of hiv infection * heart failure uncontrolled by medications * total bilirubin \> 2.0mg/dl due to hepatocellular dysfunction * ast \> 90 * serum creatinine \> 2.0 * cholesterol \> 300 mg/dl

Keywords: graft versus host disease gvhd stem cell transplantation tacrolimus sirolimus methotrexate allogeneic stem cell transplantation
pilot study for peripheral neuromuscular electrical stimulation of the quadriceps muscle

Conditions: Spinal Cord Injuries; Brain Injuries; Muscle Atrophy

Summary: feasibility study of a new medical device that will evaluate the usability and effectiveness of a cycle ergometer device associated with neuromuscular electrical stimulation (fes cycling). the study's objective is to evaluate the effect of the application of functional electrical stimulation of the new device on participants' quadriceps muscle strength in comparison to a medical device with similar characteristics and to a control group. secondarily, the study will compare the usability of the two medical devices as evaluated by the participants and the therapists who apply the treatment, as well as the participants' satisfaction with the treatment, identifying possible adverse effects.


Eligibility criteria:
inclusion criteria: * spinal cord injury, brain injury or acquired muscle weakness * managed chronic diseases * no contraindications to the practice of physical exercise * ability to communicate in oral and written portuguese exclusion criteria: * amputation of lower limbs at any level * unstable or acute fractures of lower limbs * contraindication for the practice of physical activity * open wounds in the lower limbs * consent withdraw
the effect of direct referral for fast ct scan in early lung cancer detection in general practice

Conditions: Lung Cancer

Summary: background: the primary investigation of lung cancer (lc) is for 85% of the cases conducted through general practice, sadly it tends to take a relatively long time from first time the patient is seen by their general practitioner and until they are diagnosed. lc symptoms are common, but usual because of benign diseases. only 33% of lc patients presenting with alarm symptoms. on average a general practitioner in denmark sees only one patient with newly diagnosed lung cancer a year and the doctor will therefore get the clinical experience that when they refer a patient, test often come out negative and they therefore fail to refer and delay will increase - with a poorer prognosis as a result. centrally in the diagnosis is conventional chest x-ray, which unfortunately is inefficient in many cases, while ct scanning has proven effective even for small tumors. hypothesis and aims: the project has three main hypotheses to be tested 1) the gp's use of cancer fast-track and detection of suspected lung cancer can be optimized in relation to interpretation of symptoms and subsequent referral practices and radiological investigation. 2) general practitioners with special training can change the referral routines and 3) direct access to fast ct scanning leads to earlier diagnosis of lung cancer. methods: the first part of the study is a register-based study of lung cancer patients' road to diagnosis, based on a database of newly diagnosed cancer patients in a year. second part of the study is a clinical, randomized study of the effect of referral directly to fast chest ct scan. primary endpoint is delay, secondary endpoints are referral pattern (use of fast-track packet), primary use of ct and 1-year mortality. furthermore side effects, including patient groups with increased delay. the study will contribute new knowledge to the way gp's interpret symptoms, the way they refer their patients when they suspect cancer, their use of diagnostic imaging and cancer fast-track pathways. it will then provide a unique opportunity to create the necessary knowledge about the effects of direct referral to fast ct scan and it might be a decision aid whether to open for direct ct scan in general practice for a group of patients.


Eligibility criteria:
inclusion criteria: * all practices referring to the department of pulmonary medicine, aarhus university hospital. exclusion criteria: * former lung cancer patients.

Keywords: lung cancer early detection ct scan general practice effect of computed tomography scans clinical medical education
effect of frontal transcranial direct current stimulation on bdnf in stroke patients with cognitive impairment

Conditions: Stroke

Summary: the purpose of the clinical trial is to find a treatment for stroke patients with cognitive impairment, and the main questions it aims to answer are: * \[search for effective treatments of cognitive impairment after stroke\] * \[explore the relationship between bdnf level and cognitive function\] participants will receive conventional treatment, tdcs treatment, .and then compare cognitive function and bdnf level

1. to study the therapeutic effect of transcranial direct current stimulation (tdcs) on post-stroke cognitive impairment (psci) by evaluating cognitive function and detecting plasma brain-derived neurotrophic factor (bdnf). 2. to explore the correlation between plasma bdnf level and cognitive function in patients with psci.

Eligibility criteria:
inclusion criteria: * (1)stroke patients with ct or mri imaging evidence, among which ischemic stroke met the diagnostic criteria of chinese guidelines for the diagnosis and treatment of acute ischemic stroke 2018, and cerebral hemorrhage diseases met the diagnostic criteria of chinese guidelines for the diagnosis and treatment of cerebral hemorrhage 2019; (2) there are symptoms related to cognitive dysfunction; cognitive dysfunction was assessed by rehabilitation physicians. according to the moca evaluation standard,moca score ≤26 points; according to the mmse evaluation standard, illiteracy score ≤17 points; primary school education level ≤20 points; secondary school education (including secondary school) level ≤22 points; college education (including junior college) level ≤23 points; (3)age range 40-80 years old; (4) no obvious aphasia, speech expression and attention can cooperate with the completion of evaluation and treatment; (5)the patient or the patient's family members read and agree to sign the informed consent. exclusion criteria: * (1) patients with severe diseases, such as malignant arrhythmia, acute myocardial infarction and acute heart failure, who cannot tolerate rehabilitation treatment; (2) patients with untreated intracranial aneurysms, severe epilepsy, and intracranial metals who cannot receive tdcs treatment; (3) non-psci patients with cognitive impairment, including patients with cognitive impairment left over from previous stroke and other organ disorders.
interest of a short early psychological care in women with miscarriage

Conditions: Miscarriage

Summary: miscarriage is a very common complication of pregnancy, accounting for 15.3% (95% ci 12.5-18.7%) of diagnosed pregnancies. miscarriage would affect one in ten women during her lifetime. worldwide, 23 million miscarriages occur annually. because of its frequency, miscarriage isoften considered as trivial event by caregivers. still, miscarriage can be a traumatic event. literature is consistent on the psychological morbidity associated with miscarriage. anxiety, depression, post-traumatic stress have been studied in women after miscarriage. cohort studies and clinical trials suggest that psychological and supportive interventions performed in women after miscarriage may improve women's psychological well-being and reduce miscarriage complications in subsequent pregnancies. however, to date, the literature is considered insufficient on the psychological care of women after a miscarriage.

the aim of the study will be to evaluate the interest of a short early psychological care in women with miscarriage.

Eligibility criteria:
inclusion criteria: * women with an early miscarriage (defined by a spontaneous termination of pregnancy before the 14th week of amenorrhea) * women aged more than 18 * women agreeing to participate in the study (signing the informed consent form). exclusion criteria: * ectopic pregnancy * molar pregnancy * women with recurrent miscarriages * women less than 18

Keywords: miscarriage psychological care anxiety depression post traumatic stress disorder
beta agonist nebulization in non invasively ventilated copd patients: safety, and therapeutic efficacy range.

Conditions: Chronic Respiratory Failure

Summary: randomized double-blind controlled study in parallel groups salbutamol is a β2 mimetic short-acting to be administered by nebulization in this study. during this administration, non invasive ventilation for the patient will be continued.

randomization will focus on the treatment administered (placebo or salbutamol ). after the first phase , a switch will be set up for each patient , retaining the blind it will be administered salbutamol (for those who received placebo in the first phase ) or placebo (for those receiving salbutamol ) .

Eligibility criteria:
inclusion criteria: * patient over 18 years old * patient with bpco, defined: * by an irreversible obstructive syndrome * and\\or by different arguments (histories, symptoms, physical examination, thoracic radiography, gas of the blood) * decompensation of this bpco in the form of acute respiratory failure * no argument for a dominant acute left cardiac insufficiency * consent signed by the patient * patient with national health assurance exclusion criteria: * contraindications in the not invasive ventilation * patient not volunteer for the realization of the spirometry * precautions for use of ß2 mimetic (engrave hyperthyroidism) * under guardianship patient or protection of justice * pregnant patient
russian kogenate pediatric study

Conditions: Hemophilia A

Summary: a prospective study to evaluate the effect of rfviii-fs in different prophylactic regimens on bleeding events frequency and development of arthropathy in previously treated and minimally treated hemophilia a pediatric population.


Eligibility criteria:
inclusion criteria: * male * severe hemophilia a or moderate hemophilia a * 1-12 years of age * requiring treatment with fviii exclusion criteria: * current or prior inhibitor or familial antecedents of inhibitor * surgery required during the study (9 months) * positive for hiv

Keywords: kogenate, children, factor viii, hemophilia a, prophylactic
a pilot study of a neural mobilization intervention applied to older adults with chronic musculoskeletal pain

Conditions: Chronic Musculoskeletal Pain; Chronic Pain; Chronic Musculoskeletal Disease; Older Adults

Summary: the goal of this pilot study is to evaluate the feasibility of integrating neural mobilization techniques into a multimodal physical exercise program for older adults with chronic musculoskeletal pain. the main questions it aims to answer are: * what is the average time to assess secondary outcomes for each participant? * what proportion of participants adhered and/or withdrew from the study at the end of the intervention protocol? * are there adverse events/effects associated with the intervention protocol? * what is the level of approval/satisfaction of the participants in relation to the assessment and intervention protocols? * what is the impact of the intervention protocol on participants´ pain, function, physical performance, somatosensory function, and nerve excursion (secondary outcomes)? participants will be assessed at 3 different moments: initial assessment (t0), at the end of the intervention protocol (8 weeks) (t1) and 3 months after the end of the intervention protocol (t2). the intervention protocol will consist of a multimodal exercise program (with or without integration of neural mobilization techniques) to be carried out over a period of 8 weeks at a frequency of twice a week.


Eligibility criteria:
inclusion criteria: * community-dwelling older adults aged 60 years or older, with primary or secondary chronic musculoskeletal pain in any body site and able to walk independently exclusion criteria: * individuals with post-surgical pain as a result of surgery performed in the last 6 months; * patients with a self-reported diagnoses of infection diseases, dementia, tumor/cancer, neurodegenerative diseases, stroke, uncontrolled diabetes, or at high risk of developing cardiovascular events; * those with physical limitations that make it impossible for them to carry out the intervention protocols independently (e.g., wheelchair user); * patients who are receiving another physical therapy intervention to treat their pain.

Keywords: elderly physical therapy neural mobilization
muscle analyze in patient with disc herniation

Conditions: Disk Herniated Lumbar

Summary: this study which was planned to investigate the factors affecting m. erector spinae (es), m. multifidus (mf), m. psoas major (pm) and m. quadratus lumborum (ql), which stabilize the lumbar region in the case of disc herniation. in this study, the effects of disc herniation, herniation severity, age, and spinal biomechanics were investigated.

this study was carried out on 330 individuals with and without lumbar disc herniation. all individuals were divided into 3 groups according to their age. the inclusion criteria: having only disc degeneration and not having any other neurological or orthopedic disease. patients who had previous spinal surgery, patients with lumbar scoliosis, spondylolisthesis or structural defect in the sacrum were excluded from the study.

Eligibility criteria:
inclusion criteria: * having only disc degeneration and not having any other neurological or orthopedic disease. patients who had previous spinal surgery, patients with lumbar scoliosis, spondylolisthesis or structural defect in the sacrum were excluded from the study. exclusion criteria: * patients who had previous spinal surgery, patients with lumbar scoliosis, spondylolisthesis or structural defect in the sacrum were excluded from the study.
pregnancy and neonatal follow-up of ongoing pregnancies established in clinical trial p05787 (p05712)

Conditions: Pregnancy; Neonates

Summary: the objective of this trial was to evaluate whether corifollitropin alfa treatment for the induction of multifollicular growth in women undergoing controlled ovarian stimulation (cos) prior to in vitro fertilization (ivf) or intracytoplasmic sperm injection (icsi) was safe for pregnant participants and their offspring. the primary endpoint was the take-home baby rate calculated as the number of participants with an ongoing pregnancy in base trial p05787 (nct00696800) with at least one live born infant relative to the number of participants in the base trial, and to the number of participants in the base trial with embryo transfer (et).

this is a follow-up protocol to prospectively monitor pregnancy, delivery, and neonatal outcome of all women who were treated with corifollitropin alfa or recfsh and became pregnant during base trial p05787 (nct00696800). for this trial, no study specific assessments are required, but information as obtained in standard practice will be used.

Eligibility criteria:
inclusion criteria: * participants who received at least one dose of either corifollitropin alfa or puregon®/follistim® aq cartridge in base trial p05787 (nct00696800); * ongoing pregnancy confirmed by ultrasound at least 10 weeks after embryo transfer in base trial p05787 (nct00696800); * able and willing to give written informed consent. exclusion criteria: * none

Keywords: neonatal outcome congenital malformations in-vitro fertilization controlled ovarian stimulation follow-up
a study to test if sar443809 is tolerated and safe when taken as a single dose in healthy adults

Conditions: Paroxysmal Nocturnal Hemoglobinuria

Summary: primary objective * the tolerability and safety of sar443809 secondary * the pk parameters of sar443809 * the pd activity of sar443809 * the immunogenicity of sar443809

screening: up to 56 days (day -56 to day -2). treatment: 1 day (treatment on day 1, study observation period from day -1 to day 3). follow-up and end of study: 105 days after imp administration (follow up visits from day 5 to day 78; end of study visit on day 106). total study duration for each participant: approximately 23 weeks.

Eligibility criteria:
inclusion criteria: having given written informed consent prior to undertaking any study-related procedure exclusion criteria: participants are excluded from the study if any of the following criteria apply: any participant who, in the judgment of the investigator, is likely to be noncompliant during the study, or unable to cooperate because of a language problem or poor mental development. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
self- administered acupressure for diarrhea predominant irritable bowel syndrome

Conditions: Irritable Bowel Syndrome With Diarrhea

Summary: this study aims to assess the effect of active self- administered acupressure compared to sham self- administered acupressure on the health outcome for patient with diarrhea predominant irritable bowel syndrome

research suggests promising benefits of acupuncture in terms of symptom control and quality of life improvements in patients with irritable bowel syndrome. but the cost of the needle and the invasive nature of the procedure decreases patient compliance with acupuncture. in this respect, acupressure can be taught to patients to allow them to perform it themselves, instead of being administered by practitioners. self-administered acupressure is less time-intensive, low-cost, and flexible to perform. nurses involved in irritable bowel syndrome patient care play an active role in the practitioner-patient relationship by assessing the specific symptoms that are present, determining the severity of symptoms and the impact on the irritable bowel syndrome patient's life, and being knowledgeable of available treatment options, the nurse involved in irritable bowel syndrome care becomes an essential conduit of information and a valuable facilitator of a positive practitioner-patient therapeutic relationship. in this way, nurses can help to limit the negative consequences of this common disorder and improve overall treatment outcomes in this population. . thus this study will be conducted to assess the effectiveness of active self-administered acupressure on diarrhea-predominant irritable bowel syndrome

Eligibility criteria:
inclusion criteria: * diagnosed with diarrhea irritable bowel syndrome symptoms following rome iv diagnostic criteria * agreed to be on a fixed dose of the pharmacological therapy throughout the study exclusion criteria: * patients with severe lesions in major organs such as the heart, liver, and kidney, hematopoietic diseases, or tumors * eating disorders * history of major abdominal surgery * history of neurological and mental illness * usage of other treatment rather than the medical treatment regularly 2 weeks before randomization and throughout the study * previous history of drug or alcohol abuse 6 months before randomization * pregnant and lactating women. * patient reporting of adequate relief of their irritable bowel syndrome symptoms the week preceding the randomization * patient has too mild symptoms ( obtaining less than 75 on irritable bowel syndrome symptoms severity scale at the baseline assessment) * currently participating in other clinical trials