Kornimate/medical-research-clean huggingface dataset:
power spectral analysis of eeg during equi-mac inhalation anesthesia

Conditions: Anesthesia

Summary: the purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

volatile anesthetics vary in their relative hypnotic potency. recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. however, there were no studies that demonstrate the difference of hypnotic potency using power spectral analysis of electroencephalographic signals (e.g., spectral edge frequency 95%, total power, % value of each bandage). the purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Eligibility criteria:
inclusion criteria: * patients undergoing arthroscopic knee surgery under general anesthesia using volatile anesthetics * patients with american society of anesthesiologist physical status i, ii * patients aged 19-65 years * patients obtaining written informed consent exclusion criteria: * patients with a history of any psychiatric or neurological disease * patients who had received any medication affecting the central nervous system * patients who had received medication affecting the sympathetic or parasympathetic nervous systems * patients undergoing tracheal intubation for airway management * pregnant women
implementation and effectiveness of a community-based exercise on prescription program for adults with chronic diseases

Conditions: Prescription; Physical Activity; Chronic Disease

Summary: the objectives were (1) to evaluate the characteristics of the patients referred, and (2) the effect of a community-based exercise on prescription program on their physical capacities and their quality of life. the program consisted in 30 supervised physical activity (pa) group sessions (75 min) over a 4-month period and participant were prescribed the program by their doctors. the participants had chronic diseases among type 2 diabetes, mental disorders, musculoskeletal disorders, childhood and adult obesity and stabilized cardiovascular diseases. tests and questionnaires were completed before and after the program. physical tests were the 6-minute walk test, the timed up \& go, the 30-s stand up chair, the single leg support test and the back scratch and toe-touch tests. questionnaires were the self-administered ricci and gagnon questionnaire about pa level and the 12-item short form survey for measuring quality of life. personal goal from the participants and medical objective from their doctors were collected before the program.


Eligibility criteria:
inclusion criteria: * all participant referred to the exercise on prescription program (caen) exclusion criteria: * french language not sufficiently read and/or spoken * lack of clear information on the study * alteration of higher functions or sensory disturbance making understanding and adherence to the research protocol impossible.
bioequivalency study of anastrozole 1 mg under fed conditions

Conditions: Breast Cancer

Summary: the objective of this study was to prove the bioequivalence of anastrozole tablet under fed conditions


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * history of allergic or adverse response to anastrozole or any comparable or similar product.
the results of oxford unicompartmental knee arthroplasty in patients with and without preoperative genu recurvatum

Conditions: Primary Gonarthrosis; Genu Recurvatum

Summary: the purpose of this study is to explore the effects of the oxford unicompartmental knee arthroplasty on two groups of patients, namely one with genu recurvatum before the procedure and one without. specifically, this study compare the number of occurrences of postoperative genu recurvatum and the postoperative hyperextension angles among the patients. additionally, the knee scores, the pain scores, and the functional scores for the two groups of patients are compared. materials and methods: this study prospectively followed 104 patients (114 knees) who had been treated with cemented minimally invasive surgery unicompartmental knee arthroplasty and had had a minimum of 24 months of follow-up. the patients were divided into two groups: those without preoperative genu recurvatum (85 patients; 94 knees) and those with preoperative genu recurvatum (19 patients; 20 knees). the incidence of the postoperative genu recurvatum, the postoperative hyperextension angles, the knee scores, the pain scores, and the functional scores were recorded and compared between two groups..

the patients in both groups were applied with cemented oxford unicompartmental knee arthroplasty with the same surgeon. the all patients were performed surgery with minimally invasive surgery technique. the gender, site, range of motion, alignment of prosthesis, operative time, blood loss, and posterior slope of tibial component also were recorded and compared between two groups. the incidence of postoperative genu recurvatum, gender, and site were computed using fisher's exact test. the hyperextension angle, knee score, pain score, functional score,range of motion, alignment of prosthesis, posterior slope of tibial component, operative time, and blood loss were compared with student t-test.

Eligibility criteria:
inclusion criteria: * the medial oa knee with older than 40 years of age, rom greater than 90°, varus deformity less than 25°, and flexion contractures less than 20° exclusion criteria: * patients who were diagnosed spontaneous osteonecrosis of knee (sponk), patients with intraoperative acl insufficiency, post traumatic arthritis, gouty arthritis, inflammatory joints.
a retrospective medical record review of first-line sunitinib administration schedules and outcomes among patients with mrcc in latin america (la)

Conditions: Metastatic Renal Cell Carcinoma ( mRCC)

Summary: to describe real-world demographic and clinical characteristics, treatment characteristics, and clinical outcomes among patients in latin america who were treated with first-line sunitinib for metastatic renal cell carcinoma and switched from the 4/2 to 2/1 administration schedule

understanding characteristics of patients who switched from a 4/2 to a 2/1 sunitinib schedule or initiated the 2/1 schedule in brazil, and the resulting clinical outcomes in the real-world setting • describing the occurrence of aes on the 4/2 and 2/1 schedules

Eligibility criteria:
inclusion criteria: 1. diagnosed with metastatic rcc with clear cell histology a. the patient may have been initially diagnosed with stage iv or initially diagnosed at an earlier stage and progressed to having disease at distant sites (i.e., metastatic disease) 2. initiated first-line treatment for metastatic rcc with sunitinib on the 4/2 schedule (all countries) or initiated first-line treatment for metastatic rcc with sunitinib on the 2/1 schedule (brazil only) 3. switched to the 2/1 schedule (all countries) or initiated the 2/1 schedule (brazil only) during the first treatment line between january 1, 2014, and june 30, 2018 a. the final dates defining this selection period will be dependent on country-specific ethics and reporting requirements exclusion criteria: 1. evidence of other malignant neoplasms (except nonmelanoma skin cancer or carcinoma in situ) within 5 years before switching to the sunitinib 2/1 schedule (all countries) or initiation of the 2/1 schedule (brazil only)

Keywords: sunitinib -
htd1801 in adults with nonalcoholic steatohepatitis and liver fibrosis who have type 2 diabetes or pre-diabetes

Conditions: Nonalcoholic Steatohepatitis (NASH); Type 2 Diabetes

Summary: a phase 2b, multicenter, randomized, double-blind, placebo-controlled study of htd1801 in adult subjects with non-alcoholic steatohepatitis and liver fibrosis who have type 2 diabetes mellitus or pre-diabetes.

this phase 2b, double-blind, randomized, placebo-controlled, multicenter study will evaluate the effect of htd1801, 1250 mg twice daily (bid) compared to placebo bid on histologic improvements in adult subjects with non-alcoholic steatohepatitis and liver fibrosis who have type 2 diabetes mellitus or pre-diabetes. the study will enroll approximately 210 subjects with biopsy-confirmed non-alcoholic steatohepatitis and evidence of stage 2 or stage 3 liver fibrosis. subjects will receive investigational product for up to 60 weeks.

Eligibility criteria:
key inclusion criteria: * clinical diagnosis of non-alcoholic steatohepatitis (nash) upon central read of a liver biopsy obtained no more than 6 months before day 0. * histologic evidence of fibrosis stage 2 or stage 3 as defined by the non-alcoholic steatohepatitis (nash) clinical research network (crn) scoring of fibrosis. * clinically documented diagnosis of type 2 diabetes mellitus for at least 6 months prior to screening or prediabetes at screening. * bmi \>25 kilograms/meters squared (\>23 kilograms/meters squared if asian). key exclusion criteria: * fibrosis stage 4. * history of alcohol or substance abuse or dependence. * liver disease unrelated to non-alcoholic steatohepatitis. * history of significant cardiovascular disease. * history of type 1 diabetes. * inability or unwillingness to undergo 2 planned liver biopsies or 1 planned biopsy if historical liver biopsy was used to confirm eligibility at entry.
guiding multi-modal therapies against minimal residual disease by liquid biopsies

Conditions: Pancreatic Adenocarcinoma

Summary: the overall objective of this study is to confirm that ctdna detected after curative intended treatment for pdac is a marker of residual disease and for risk-of-recurrence, and applicable in clinical practice. primary objective to confirm that ctdna analyses performed after pdac treatment can identify patients with a high risk-of-recurrence. specifically, we want to determine the association between disease-free survival (dfs) and ctdna detection status after (1) curative-intended surgery and (2) adjuvant chemotherapy.

the study will prospectively enroll patients who undergo potentially curative surgery for pdac. the intervention is repeated blood sampling at pre-defined time points. patient identification patients with pdac are screened for eligibility by the involved physicians based on the protocol of the multidisciplinary tumor board (mdt). the screening will be done based on the electronic health record in the electronic journal (at present, for example, take care). the national health record may be accessed for some patients to complete the record. patient recruitment and informed consent the involved physicians screen patients meeting the inclusion criteria specified below. eligible patients are approached in person or initially by phone, after they have been informed about the diagnosis and the planned surgery. patients are given written and oral information about the project by a trained research nurse or by an involved physician. informed consent will be obtained before the beginning of any study-related procedures. the signed and dated consent forms are scanned into the project's electronic database and stored physically in a locked space.

Eligibility criteria:
inclusion criteria: * pancreatic ductal adenocarcinoma, according to the assessment of the mdt. * age 18 years or older. * patient able to understand and sign written informed consent in swedish. * scheduled for curative intent surgical resection. exclusion criteria: * hereditary pancreatic cancer. * verified distant metastases. * patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits and/or otherwise considered by the investigator to be unlikely to complete the study. * other cancers (excluding prior pancreatic cancer or skin cancer other than melanoma) within 3 years from eligibility screening.

Keywords: liquid biopsy
second primary lung cancer cohort study (sport)

Conditions: Lung Cancer

Summary: patients who have had curative treatment for lung cancer are at an increased risk of developing second primary lung cancers (and other cancers) over the next 10 years. doctors need to develop better ways of monitoring patients during follow up so we can intervene as quickly as possible with further treatments. measuring dna in the blood which has come from the tumour, so called circulating tumour dna (ctdna), may be one way to do this.

this is a multi-centre, observational basic science study to follow patient who have undergone radical treatment, surgery or radiotherapy for non-small cell lung cancer (nsclc) between two and five years previously. following consent, participants will be asked to provide blood samples every six months for up to the next five years. information from their routine clinical care, including information from any imaging, diagnostic tissue samples and blood tests will be collected. we will also request access to any original surplus diagnostic material, as well as future, excess tissue from diagnostic samples. blood samples will be analysed using various new scientific techniques looking to correlate emergence of new primary cancer (or recurrence of original nsclc) with blood based markers.

Eligibility criteria:
inclusion criteria: * previous treatment with curative intent (surgery or radical (chemo)radiotherapy) for stage i-iiia primary nsclc * at least two years post first treatment date of first primary nsclc * able to provide informed consent exclusion criteria: * primary lung tumour was a carcinoid tumour * in the opinion of the managing clinician, thought unlikely to survive 12 months from time of potential recruitment.

Keywords: lung cancer non-small cell lung cancer
compassion for psychiatric disorders and self-stigma

Conditions: Bipolar Disorder; Schizophrenia; Depression; Borderline Personality Disorder; Autism Spectrum Disorder

Summary: people with mental disorders face frequent stigmatizing attitudes and behaviors from others . in response to this, they tend to isolate themselves, with the risk of impeding care and the process of recovery and integration into society . stigmatization can also be assimilated by patients themselves - i.e. self-stigma. self-stigma is involved in diminished coping skills that lead to social avoidance and difficulties in adhering to care . reducing self-stigma and its emotional corollary, shame, is thus crucial to attenuate the disability associated with mental illness. shame is inherent to self-stigma and leads to difficulties in adhering to care as well as greater severity of clinical presentations . compassion focused therapy (cft) is a third wave cognitive behavioral therapy that targets shame reduction and hostile self-to-self relationship and allows for symptom improvement while increasing self-compassion, a major resilience factor . although shame is a prominent part of the concept of self-stigma, the efficacy of cft has never been evaluated in individuals with high levels of self-stigma. in this study, the investigators will evaluate the efficacy and acceptability of a group based cft program on decreasing self-stigma, compared to treatment as usual (tau) and a psychoeducation program whose efficacy has been assessed in a previous trial.


Eligibility criteria:
inclusion criteria: 1. patient ≥18 years of age 2. patient informed of the results of the preliminary medical examination 3. patient affiliated to a social health insurance plan (beneficiary or beneficiary's family) 4. patient with one or several diagnoses of chronic psychiatric disorder (schizophrenia, schizoaffective disorder, bipolar disorder, recurrent major depression, borderline personality disorder) or a neurodevelopmental disorder (autism spectrum disorder) treated as an outpatient or in a day hospital 5. cgi-severity score\ 2.5; lysaker et al., 2007) exclusion criteria: 6. patient in an exclusion period determined by a previous or ongoing study 7. patient participating in an interventional study involving psychotherapy or an experimental drug 8. patient in acute episode of their disorder according to the cgi severity score 9. patient in a medical emergency or immediate life-threatening situation 10. patients with an intellectual disability (iq\<70) estimated via the fnart (mackinnon \& mulligan, 2005) 12. legal issues: care under constraint or patient deprived of freedom because of a judicial measure 13. patient who does not speak and read french sufficiently
adapting treatment delivery to improve retention in evidence-based ptsd treatment

Conditions: Stress Disorders, Post-Traumatic

Summary: posttraumatic stress disorder (ptsd) is prevalent among veterans and effective evidence-based psychotherapies (ebps) for ptsd have been implemented within the veterans health administration (vha). however, retention in ptsd ebps is poor. premature dropout is associated with worse clinical outcomes and greater healthcare utilization. delivery of ptsd ebps in a massed format, typically three or more days per week delivered within a month, have shown promise for increasing retention. the present study is a pilot feasibility and acceptability study comparing massed ptsd treatment to treatment as usual (e.g., typically weekly treatment).


Eligibility criteria:
inclusion criteria: * veterans aged 18 years or older; * meets criteria for current ptsd; * willingness to be randomized to either condition (e.g., ebp-massed or ebp-tau); * decision to receive cpt or pe in a treatment planning session with a durham trauma recovery program clinic provider; * ability to provide informed consent exclusion criteria: * high acute suicide risk; * active manic symptoms that would likely interfere with treatment; * active psychotic symptoms that would likely interfere with treatment; * currently in a concurrent trauma-focused evidence-based treatment for ptsd

Keywords: stress disorders, post-traumatic psychotherapy mental health veterans
analytical validation of wrist-based assessment of nocturnal scratch in atopic dermatitis and psoriasis

Conditions: Atopic Dermatitis; Psoriasis

Summary: pruritis is a common symptom in patients with atopic dermatitis and psoriasis. patients with atopic dermatitis and psoriasis often report pruritis-associated sleep impairments and scratching behaviors during nighttime and the negative impact on their quality of life. however, nocturnal scratch behavior and sleep impairment are poorly understood due to the difficulties in quantifying these symptoms in patients' daily lives. this study deploys multiple technologies (polysomnography, video capture, wrist sensors, clinician-reported outcomes, and patient-reported outcomes) to develop and validate a wrist-based solution to quantify nocturnal scratch.


Eligibility criteria:
inclusion criteria for participants with atopic dermatitis: * at least 14 years old * less than 70 years old * clinical diagnosis of atopic dermatitis * peak pruritis nrs score \> 1 inclusion criteria for participants with psoriasis: * at least 18 years old * less than 70 years old * clinical diagnosis of plaque psoriasis * at least a peak pruritis pnrs of 4 * itch is caused by psoriasis, as determined by clinician exclusion criteria: * non-atopic dermatitis or psoriasis-related sleep disorder (e.g., diagnosed sleep apnea, restless leg syndrome etc...) * movement disorder * flare or infection on the wrist * infected atopic dermatitis or psoriasis lesions * pregnant or lactating women * shift workers or participants with jetlag * current diagnosis of depression

Keywords: nocturnal scratch itch validation sleep impairment pruritis
developing an atlas to teach nurses to clean micro-instruments used in cataract surgery: effect on patient safety

Conditions: Cataract

Summary: aims and objectives the purpose of this study was to develop an atlas to explore the effect of micro-instrument cleaning on the safety of cataract surgery. background cataract surgery safety is affected by many factors, the most influential of which is the quality of instrument cleaning. previous studies focused on the reaction in the eye after cataract surgery. none offered a solution for manually cleaning ophthalmic micro-instruments or response data for surgical instruments after cataract surgery. design the study was designed to collect quantitative data derived from postoperative ocular evaluation. methods we developed an atlas that details micro-instrument cleaning that could be used to train nurses to have this skill. a total of 120 cataract patients were divided evenly into experimental and control groups. in the experimental group, cataract surgery was undertaken using microsurgical instruments that were cleaned by the atlas-trained nurses. in the control group, micro-instruments were used that had been cleaned by non-atlas-trained nurses. all the patients underwent the same postoperative tests: anterior chamber cell counts and visual and intraocular pressures on postoperative days (pods) 1, 3, 7, and 14.

a single surgeon conducted all of the surgery and follow-up all patients

Eligibility criteria:
inclusion criteria: * cataract patients exclusion criteria: * patients with metabolic disease, immune disease, and/or retinopathy were not included in this study.

Keywords: anterior chamber flare cataract intraocular pressure micro-instrument photograph-based atlas visual training nurse