Kornimate/medical-research-clean huggingface dataset:
the impact of the covid-19 (sars-cov-2 disease) on psychopathology

Conditions: Psychosis;Schizophrenic; Personality Disorders; Mood Disorders; Anxiety Disorders; Post Traumatic Stress Disorder

Summary: the outbreak of the sars-cov-2 pandemic may be considered a traumatic phenomenon. in a sample of subjects suffering from different psychiatric disorders, psychopathological status and post-traumatic stress disorder (ptsd) symptoms over time are assessed using specific psychometric scales. in a sample of healthy controls ptsd symptoms are evaluated by impact of event scale revised (ies-r) and compared to patients' scores. we hypothesize that a significant number of psychiatric outpatients have experienced a clinical psychopathological worsening and a greater prevalence of ptsd symptoms compared to the general population. the study of the potential psychopathological changes could represent a useful contribution to deepen the understanding of psychological consequences of the pandemic.

sars-cov-2 epidemic is a worldwide phenomenon which generated fear, anxiety, depression and ptsd symptoms, as a consequence of the high number of deaths and the restricted measures adopted by the italian government to stem the spread of the virus. the aims of the study are: (1) to investigate potential psychopathological changes over time in a sample of patients affected by different psychiatric disorders (schizophrenia, bipolar disorder, major depression, anxiety/obsessive-compulsive disorder (ocd), personality disorders); (2) to compare patients and healthy controls in terms of post-traumatic symptoms. outpatients affected by different psychiatric disorders are recruited during their routine visits and demographic/clinical variables are collected from their medical records. psychopathological status and ptsd symptoms are retrospectively assessed using specific psychometric scales, such as brief psychiatry rating scale (bprs), clinical global impression (cgi), disability scale (diss), hamilton anxiety rating scale (ham-a), hamilton depression rating scale (ham-d), montgomery and asberg depression rating scale (madrs), young mania rating scale (ymrs), yale-brown obsessive-compulsive scale (y-bocs), ies-r. the assessment is performed over time at three time points: t0 corresponding to the outbreak of the pandemic (january-february 2020), t1 which was the lockdown period (march-april 2020) and t2 corresponding to the reopening and restarting (may-june 2020). descriptive analyses of the whole sample will be performed. then, mixed linear regression models will be run to investigate the change over time in patients' psychometric scores and whether it differs among different diagnostic groups. moreover, same analyses will be performed to compare patients and healthy subjects in terms of change of ies-r scores over time.

Eligibility criteria:
inclusion criteria: * understanding of the italian language * ability to understand and sign written informed consent exclusion criteria: * severe mental retardation * pregnancy or post-partum period * severe or chronic medical condition * health workers
newly diagnosed mature b-all, burkitt's lymphoma and other high-grade lymphoma in adults

Conditions: Burkitt's Lymphoma; Burkitt's Leukemia; Mediastinal Neoplasms; Lymphoblastic Lymphoma; Large Cell Anaplastic Lymphoma

Summary: the study evaluates the efficacy and tolerability of alternating short cycles of high-dose and conventional chemotherapy in combination with rituximab in cd20 positive patients, followed by local radiation therapy in the case of initial mediastinal or central nervous system (cns) involvement or a residual tumor after chemotherapy. a dose-reduced regimen is offered for patients estimated to be over 55 years, biologically.


Eligibility criteria:
inclusion criteria: * burkitt's leukemia or burkitt's lymphoma or primary mediastinal large b-cell lymphoma or b-precursor lymphoblastic lymphoma or large cell anaplastic lymphoma * age \> 15 years * written informed consent exclusion criteria: * serious secondary diseases, including psychiatric conditions, under which the required therapy compliance is not to be expected * hiv infection * secondary lymphoma following prior chemotherapy/radiotherapy or active second malignancy * known severe allergy to foreign proteins * pre-treatment other than 1 cycle chop or similar; \< 1 week of another chemotherapy. * pregnancy or nursing * participation in other studies that interfere with study therapy

Keywords: high-grade nhl de novo mature b-all burkitt's nhl chemotherapy rituximab primary mediastinal diffuse large cell lymphoma b-precursor lymphoblastic lymphoma
annexin imaging in dissection of the descending aorta

Conditions: Chronic Dissection of Thoracic Aorta (Disorder)

Summary: the relationship between the presence of a partial thrombus and aortic dilation after type b dissection has recently been reported. the originality lies in the idea of imaging thrombus activity to predict dilation after type b dissection. the innovative character is based on the use of annexin scintigraphy.

to establish the proof of concept in humans of the link between the intensity of 99mtc-annexin v-128 binding in the descending thoracic aorta and the progression of aortic diameter in patients with type b aortic dissection.

Eligibility criteria:
inclusion criteria: * patient whose age is ≥ 18 years old * any patient seen more than 6 months and less than 5 years after a dissection involving the descending aorta at bichat hospital, whether it is a dissection of the descending aorta alone or a dissection of the ascending aorta extended to the descending aorta * dissection of the uncomplicated descending thoracic aorta: not requiring surgery or stent implantation within the first 6 months after acute dissection * effective contraception for women of childbearing age exclusion criteria: * scheduled procedure for dissection of the descending aorta * contraindication to aortic ct with injection of contrast media: renal failure with creatinine clearance \ 200 µmol/l; allergy to contrast media * history of surgery or stent implantation in the descending thoracic aorta * pregnant or breastfeeding women * patient under guardianship or trusteeship * non affiliation to social security or cmu (beneficiary or assignee) * patient refusal to participate in the study

Keywords: aorta type b dissection descending aorta dissection annexin
body movements analysis during sleep in very premature infants

Conditions: Sleep

Summary: sleep is a key factor for normal brain development of the newborn. however, it is poorly studied and little is known about its characterization, especially in premature infants. body movements during sleep are easy to evaluate but studies on their relationship to normal sleep states are scarce and limited. this project aims to characterize body movements during sleep, assessed by electroencephalography, in very premature infants. then, a correlation between body movements, sleep organization and neurodevelopmental outcome will be evaluated at 3 years of age.


Eligibility criteria:
inclusion criteria: * infants born between 26 and 32 weeks gestation exclusion criteria: * genetic abnormality * neurological pathology such as intraventricular hemorrhage \> grade 2 * any medication know for altering electroencephalography recording

Keywords: premature infant sleep state body movement neurodevelopmental outcome
gait retraining in patients with joint hypermobility syndrome/hypermobile ehlers danlos syndrome

Conditions: Joint Hypermobility; Ehlers-Danlos Syndrome; Hyperextension Knees

Summary: this study evaluates the efficacy of gait retraining with biofeedback in the treatment of neuromusculoskeletal symptoms in patients with joint hypermobility syndrome/hypermobile ehlers danlos syndrome. half of participants will participate in a gait retraining program, while the other half will continue standard care.


Eligibility criteria:
inclusion criteria: * ehlers-danlos syndrome hypermobile type as defined in the 2017 international ehlers-danlos syndrome classification exclusion criteria: * other heritable and acquired connective tissue disorders, autoimmune rheumatologic conditions, pregnancy, history of lower limb surgery, cardiovascular limitations, visual limitations.
comparison of lateralized rtsa with and without subscapularis repair

Conditions: Arthritis Shoulder

Summary: the purpose of this double-blind randomized controlled trial is to compare patient-reported, clinical, and functional outcomes in patients undergoing rtsa with and without subscapularis repair after placement of a modern "lateralized" implant over the course of 24-months postoperative.

the main objective of this study is to compare patient-reported outcome measures (proms), and clinical and functional outcomes between rtsa with and without subscapularis repair. the specific aims for this study are: specific aim 1: to determine if there is a difference in prom scores between rtsa with and without subscapularis repair during the 24-month postoperative period. specific aim 2: to determine if there is a difference between the two surgical approaches with respect to shoulder function, specifically range of motion and strength, during the 24-month postoperative period. specific aim 3: to determine if there is a difference in shoulder dislocation rates between rtsa with and without subscapularis repair during the 24-month postoperative period. specific aim 4: to determine if there is a difference in surgical complications, re-operation or revision rates between rtsa with and without subscapularis repair during the 24-month postoperative period. specific aim 5: to quantify the operative times for rtsa with and without subscapularis repair, and determine if there is a difference between the two approaches.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of glenohumeral arthritis, rotator cuff arthropathy, or massive irreparable rotator cuff tear with surgeon-patient decision to undergo rtsa * first rtsa implantation * absence of neoplastic diseases at the treated site * fatty infiltration of the subscapularis is low-grade (i.e. goutallier \< grade 3) based on pre-operative ct performed as standard of care in the patient group exclusion criteria: * previous shoulder arthroplasty (hemi-, total shoulder, or rtsa) * avascular necrosis * post-infectious arthritis * proximal humerus fracture * inflammatory arthritis * inability to communicate in english * unable to return for study visits to 24-months post-operative (e.g. unable to arrange transportation to study appointments, plans to relocate, etc.) intra-operative exclusions: * subscapularis with fatty infiltration (goutallier ≥ 3) * subscapularis that is deemed to be irreparable. an irreparable tendon is defined as one that is not of sufficient quality or does not allow adequate excursion to reach the repair site * any anatomical or patient characteristic that warrants a non-lateralized implant

Keywords: reverse total shoulder arthroplasty subscapularis repair
minimally invasive detection of lymphatic micrometastases in pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the major goal of this project is to reduce unnecessary pancreatic resections, namely resection in those patients with non-regional lymph node metastatses that cannot be cured with surgical resection. by combined minimally invasive methods for non-surgical biopsy and highly sensitive molecular assays for cancer cells, we believe we can increase the ability to detect distant lymph node metastases prior to surgical resection, and direct those patients for more appropriate therapy (including possible neo-adjuvant chemotherapy with or without surgery). we hypothesize that the combination of eus-fna and polymerase chain reaction (pcr) of a multimarker panel will increase the sensitivity for malignant lymph nodes compared with eus-fna cytology in patients with pancreatic ductal adenocarcinoma.


Eligibility criteria:
inclusion criteria: * patients with a mass in the pancreas suspicious for adenocarcinoma without biopsy proven distant metastases. * patients who are scheduled for clinically indicated eus exclusion criteria: * patients who are medically unfit for endoscopic sedation or surgery due to severe comorbid disease such as uncontrolled coronary disease, or oxygen dependant pulmonary disease. * patients who have any other malignancy other than basal cell carcinoma within the past 5 years.
comparison of external event recorders for atrial fibrillation monitoring

Conditions: Atrial Fibrillation

Summary: ablation of atrial fibrillation is a well established treatment method to restore normal sinus rhythm and eliminate the need for continued antiarrhythmic therapy and anticoagulation. absence of symptomatic and asymptomatic atrial fibrillation should be considered necessary for discontinuation of anticoagulation therapy. presently, recurrence of atrial fibrillation is usually determined with the use of a non looping event monitor which is typically used by the subject at the time of symptomatic arrhythmia. this method does not detect asymptomatic atrial fibrillation. random asymptomatic recording can be added, but the chance for detecting recurrence of arrhythmia is not great. too frequently, the success rates of af ablation procedures are inflated by insufficient follow up and patient's limited compliance in reporting and recording episodes of recurrent arrhythmias. often times, it is very inconvenient for patients to wear external event recorders. allergies to the sticky pads that are needed for most of the external monitoring devices continues to be a problem. implantable loop recorders have the advantage of detecting symptomatic and asymptomatic atrial fibrillation continuously. they also offer the convenience of monitoring for up to 18 to 24 months without significant patient discomfort. however, implantation and explantation of these devices involves a limited surgical procedure as well as considerable experience. in this study we attempt to assess the differences in these two types of monitoring systems in assessing the long term efficacy of af ablation.


Eligibility criteria:
inclusion criteria: * all subjects who undergo radiofrequency ablation of paroxysmal af. exclusion criteria: * subjects with known allergy to sticky patches of event monitor * subjects with skin infection or other problems on the chest that interferes with monitor implantation * subjects who are scheduled for radiation therapy * subjects who are scheduled for therapeutic ultrasound (like lithotripsy) * subjects who are scheduled for mri * subjects who are scheduled for a procedure that uses diathermy. * subjects, in the opinion of the investigator, are not suitable candidates for the study * subjects that do not have analog telephone line at home. * existing cardiac rhythm management device (e.g., pacemaker or icd)

Keywords: atrial fibrillation
the benefits of telephone follow-up (tfu)

Conditions: Mental Health Issue

Summary: this study will investigate the impact of a brief telephone follow-up following a mental health assessment in the emergency department. the purpose of the telephone call will be to provide psycho-education, clarify any questions and reinforce discharge planning.

this is a randomized controlled trial. the experimental group will receive a phone call within 72 hours of discharge to provide psycho education, clarify any questions they may have and to reinforce discharge plans made in the ed. the control group will not receive this phone call. within 30 days of discharge, both groups will receive a phone call to collect data on treatment compliance including medication and follow-up adherence and if any additional visits to the emergency department were necessary.

Eligibility criteria:
inclusion criteria * discharged from the ed * age of majority * competent. exclusion criteria * incompetent, * under 18 * admitted to the hospital

Keywords: telephone follow up
evaluation of patients with unusual diagnostic or treatment considerations

Conditions: Healthy; Tooth Disease

Summary: this study offers evaluation and treatment of patients with unusual diagnostic or treatment considerations. it is not designed to test new treatments; rather, patients will receive current standard of care treatments. the purposes of the study are: 1) to allow nidcr staff an opportunity to maintain and improve their clinical skills; and 2) to evaluate referred patients for research potential. (participants in this protocol will not be required to join a research study; the decision will be voluntary.) patients in need of dental/oral diagnosis and therapy of interest to nidcr staff dentists may be eligible for this protocol. participants will have a comprehensive dental examination and may receive part or all of their treatment at the nidcr clinic. diagnostic procedures, materials and treatments used in this study are limited to those widely accepted in dentistry and are non-experimental in nature.

the proposed pilot project will allow the staff of the dental clinic oral medicine fellowship program to accept patients, for diagnosis and conventional therapy, which do not otherwise meet the criteria for any of the current nidcr research protocols. this clinical examination and therapy by dental clinic practitioners will provide an excellent forum for the observation of oral conditions and phenomena that may generate scientific inquiries and provide valuable educational experiences consistent with the goals of the oral medicine program.

Eligibility criteria:
patients in need of dental/oral diagnosis and therapy which are of interest to one or more of the staff dentists.

Keywords: general dental diagnostic therapeutic
rct comparing avatar intervention to supportive intervention to reduce cannabis use in patients with psychotic disorders

Conditions: Psychotic Disorders; Cannabis Use Disorder; Mental Health Disorder

Summary: the goal of this clinical trial is to conduct a single-blind randomized controlled trial to verify whether the avatar intervention has greater efficacy over supportive intervention to reduce cannabis use in patients with psychotic disorders.

psychotic disorders (pd) are characterized by a loss of contact with reality. cannabis use is one of the key factors leading to psychiatric re-hospitalization in pd. in these populations, cannabis use is also associated with depressive symptoms, medication non-compliance, hostility as well as reduced quality of life. unfortunately, there is no evidence-based intervention available for the treatment of cannabis use disorder (cud) in this population. novel interventions for cud are thus critically needed. virtual reality-based therapies are a promising avenue that allow patients to try novel strategies in real time instead of having to learn abstract rules. to fill a clinical need, the investigators have created a distinctive intervention for cud in patients with pd. the avatar intervention displays strong experiential and relational components that are crucially missing in conventional interventions. hence, the primary outcomes are reductions in cannabis use, cannabis use disorder severity, and increased quality of life. the investigators will also explore whether the greater improvements attributable to the avatar intervention persist in time, and perform analyses on sex/gender, motivation to change cannabis habits, psychotic relapses, and thc metabolite levels. noteworthily, cannabis-related hospitalizations have been identified as one of the core indicators to measure the success of cannabis legalization. as a result, there is a pressing need to design innovative interventions that could have a significant impact on this costly and prime outcome. as there is no evidence-based therapeutic options for cud in patients with pd, the current trial will contribute to the validation of a novel approach and create new therapeutic possibilities.

Eligibility criteria:
inclusion criteria: * males or females over 18 years of age who meet the dsm-5 criteria for cud (≥4 criteria) ; * patients will meet the dsm-5 criteria for schizophrenia, schizoaffective disorder, or bipolar disorder with psychotic symptoms. diagnoses will be established with the structured interview for dsm-5 (scid-5). exclusion criteria: * current sud for a substance other than cannabis ; * ongoing pharmacological or psychological treatment for cud ; * ongoing detoxification for cannabis withdrawal ; * presence of neurological disorders ; * presence of a severe and unstable physical illness ; * inability to provide consent.

Keywords: cannabis virtual reality intervention psychotic disorders substance use disorders
access to a sit-stand computer workstation and back pain

Conditions: Low Back Pain; Back Pain

Summary: the purpose of the study is to evaluate the changes in back pain from access to a sit-stand workstation. other muscle and joint pain and/or discomfort will also be evaluated. we hypothesize that access to a sit-stand workstation will allow one to experience postural variation and reduce back pain.


Eligibility criteria:
inclusion criteria: * back pain lasting ≥3 months and reported at a minimum of 4 out of 10 on the pain scale. * sits \>6 hours out of an 8-hour work day for work purposes * able and willing to fill out a daily survey for the first week prior to randomization * participants must be \>18 years of age. there are no gender/race-ethnic restrictions. * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * unable to stand for at least 10 minutes. * currently using a sit-stand desk

Keywords: back pain low back pain sit-stand workstation standing desk
exploring the relationship between occlusion and degenerative tmj disorders: a comparative clinical study

Conditions: Degenerative Joint Disease; TMD

Summary: the study "exploring the relationship between occlusion and degenerative tmj disorders: a comparative clinical study" investigated the efficacy of occlusal therapy in managing degenerative temporomandibular joint (tmj) disorders. conducted over 6 months with 150 patients, it compared three groups: occlusal therapy (group 1), conventional treatment (group 2), and routine care (group 3). group 1 showed significant improvements, including a 65% pain reduction, 51% better jaw function, slower joint degeneration, 64% less muscle tension, 24% improved jaw mobility, and enhanced quality of life, outperforming the other groups. the findings support occlusal therapy's role in multidisciplinary tmj management, though long-term studies are needed.


Eligibility criteria:
inclusion criteria: adults aged 18 to 65 years clinical diagnosis of moderate to severe degenerative temporomandibular joint (tmj) disorder, confirmed by: radiographic evidence (e.g., cartilage thinning, joint space narrowing) symptoms such as jaw pain, restricted jaw movement, or muscle tension ability to provide written informed consent no recent trauma to the tmj or oral structures exclusion criteria: diagnosed rheumatoid arthritis or other autoimmune joint conditions serious cardiovascular, neurological, or systemic disorders pregnant women patients with contraindications for orthodontic procedures or occlusal splint use history of tmj surgery uncontrolled bruxism or other parafunctional habits that require alternative treatment strategies

Keywords: tmd occlusal therapy degenerative joint disease pain management biomechanical stress