Kornimate/medical-research-clean huggingface dataset:
evaluation of antimicrobial, post operative pain of cinnamon extract versus sodium hypochlorite irrigant following pulpectomy of primary teeth

Conditions: Irreversible Pulpitis; Caries,Dental

Summary: the aim of the study is to evaluate effectiveness of cinnamon extract versus sodium hypochlorite as root canal irrigant for in pulpectomy of primary teeth in reduction of bacterial count .

preservation of primary teeth with non-vital pulp is a major problem in pediatric dentistry, as it is a poly-microbial and dominated by obligatory anaerobic bacteria. regarding these case preferable treatment modality is pulpectomy . the objective of pulpectomy is complete removal of necrotic and irreversibly infected pulp of an affected tooth but due to limited ability of mechanical preparation to eliminate entrapped micro-organisms in the canal space owing to the tortuous and complex nature of the root canal system .thus, the use of antimicrobial agents has been recommended as an adjunct to mechanical instrumentation in deciduous teeth . due to potential side effects, safety concerns of synthetic drugs and cytotoxic reactions of commercial intra canal irrigants and their limited ability to eliminate bacteria from dentinal tubules . finding the best irrigating solution for endodontic therapy in primary and permanent teeth is still a working progress .there is a growing interest in using sustainable products of natural origin as an alternative to commercially available industrial ones .cinnamon , which has gained popularity in recent time due its antibacterial , antifungal , anti-inflammatory \& antiseptic activity . it has shown effectiveness against s. mutans and e. fecalis organisms . it is also known to show a wide spectrum of action on gram positive and gram negative bacteria .

Eligibility criteria:
inclusion criteria: * children: 1. aged 4 to 8, in good general health, and medically free. 2. cooperative patients who will comply to dental treatment . 3. parents provided with written informed consent. 4. no previous history of antibiotics administration or last dose was taken from at least 2 weeks. * teeth: 1. carious primary molars with irreversible pulpitis. 2. presence of localized swelling ,sinus and pain on percussion which indicate non vital pulp . 3. presence of periapical and furcation radiolucency . 4. in periapical radiograph teeth have no more than 1/3 of root resorption. exclusion criteria: * children: 1. children with medical, physical, or mental conditions. 2. severly uncooperative children . * teeth: 1. primary molars with any congenital anomalies. 2. teeth with un-restorable crowns . 3. root resorbtion more than half of the root. -

Keywords: antimicrobial and post operative pain evaluation
aphasia therapy: factors of efficacy

Conditions: Aphasia

Summary: constraint-induced aphasia therapy (ciat) has proven effective in stroke patients. it has remained unclear, however, whether intensity of therapy or constraint is the relevant factor. this study will give an answer to this question to improve speech and language therapy.

although there is clear evidence that aphasia therapy is effective, questions remain as to the intensity of administered therapy, the preferred therapeutic approach and its initiation with regard to stroke onset. ciat is a a high intense group therapy administered over 2 weeks. additionally, patients have to communicate solely in spoken words or sentences (constraint). this study compares ciat with an approach of the same intensity without constraints and a less intense house-typical therapeutic approach.

Eligibility criteria:
inclusion criteria: * first ever stroke * suffering from aphasia exclusion criteria: * severe cognitive or attentional impairments * severe depression * left-handedness * severe dysarthria * apraxia of speech * severe deafness * additional neurological diseases affecting speech (e.g. parkinson's disease)

Keywords: communication disorders language and speech disorder rehabilitation stroke
aerobic exercise for the improvement of cognition and enhancement of recovery in post-acute schizophrenia

Conditions: Schizophrenia

Summary: the study investigates the efficacy of aerobic exercise on cognitive performance and brain plasticity in schizophrenia.

this multi-center, two-arm, parallel-group, randomized placebo-controlled add-on clinical trial investigates the efficacy of aerobic exercise on cognitive performance and brain plasticity in schizophrenia. the aim is the enhancement of recovery with the use of 26 weeks of continuos endurance training (aerobic exercise) with stationary bicycles or a balance and tone program consisting of exercises for flexibility, core strength, balance and relaxation. followed by a follow-up period of 26 weeks.

Eligibility criteria:
inclusion criteria: * informed consent given by the subject; dsm-iv-tr diagnosis of schizophrenic psychosis (295.10-30, 295.90); age 18 to 65 years, male or female; panss at baseline: total score ≤ 75, proper contraception in female patients of childbearing potential; treatment with one or two antipsychotics in a stable dose of at least two weeks, body mass index between 18 and 40. exclusion criteria: * lack of accountability; positive urine drug-screening for illicit drugs at screening (except benzodiazepines); serious suicidal risk at screening visit; other relevant interferences of axis 1 according to diagnostic evaluation (mini); other relevant neurological or other medical disorders; pregnancy or lactation.

Keywords: exercise
myocardial infarction size reduction with atorvastatin

Conditions: Myocardial Infarction; Reperfusion Injury

Summary: the purpose of this study is to determine if oral atorvastatin administered just before percutaneous coronary angioplasty for acute myocardial infarction improves early and late heart function as compared to placebo.

left ventricular remodelling after a myocardial infarction refers to changes in shape and function of the infarcted and uninfarcted myocardium. remodelling begins minutes after acute myocardial infarction and may continue for months or years, leading to dilation of the left ventricle (lv) and an increased lv volume. as studies show, lv volume strongly correlates with long-term mortality. reperfusion after a period of ischaemia (through medication or ptca) leads to so-called 'reperfusion injury'. this results in myocardial dysfunction and damage, which can lead to lv remodelling. in a study where atorvastatin was administered at the onset of reperfusion infarct size was reduced. atorvastatin led to protection of the reperfused myocardium, independently of its effects on cholesterol. the objective is to measure the effect of atorvastatin, administered orally before reperfusion therapy by ptca, on infarct size and microvascular reperfusion.

Eligibility criteria:
inclusion criteria: * consecutive patients (aged \> 18 years) who are to undergo a primary pci for a first acute st elevation myocardial infarction will be asked to participate in this study. exclusion criteria: * previous myocardial infarction * previous coronary artery bypass grafting (cabg) * cardiac rhythm is other than normal sinus rhythm. * electrical instability. * the patient is in killip class 3 or 4 of heart failure. * need for intra aortic balloon counterpulsation therapy * the patient is unable to hold his/her breath for up to 20 seconds due to age or concomitant illness. * implanted electronic devices are present: pacemakers, internal defibrillators, ecg-registration devices, neurostimulators, implanted drug infusion devices, cochlear implants etc. * previous vascular surgery: aneurysm clip, carotid artery vascular clamp, aortic clips, or venous umbrella * prosthesis (orbital/penile, etc.) * spinal/intra-ventricular shunts. * swan-ganz catheter; transdermal delivery systems. * metal fragments: eye, head, ear, skin. * implants held by magnets. * known allergy to mr contrast media * prior use of statins * no pci performed * no recanalisation achieved

Keywords: acute myocardial infarction primary angioplasty reperfusion damage atorvastatin placebo early left ventricular remodelling late left ventricular remodelling cardiac mri statin transluminal, percutaneous coronary angioplasty
a study to evaluate efficacy of ivacaftor in subjects with cystic fibrosis who have a 3849 + 10kb c→t or d1152h cftr mutation

Conditions: Cystic Fibrosis

Summary: this study will evaluate the efficacy of ivacaftor treatment in subjects with cf 6 years of age and older who have a 3849 + 10kb c→t or d1152h cftr mutation.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cf based on protocol-specified clinical features and at least one of the following: increased sweat chloride level, identification of 2 cf causing mutations, or demonstration of abnormal nasal epithelial ion transport. * a 3849 + 10kb c→t or d1152h mutation on at least 1 cftr allele. * fev1 ≥40% of predicted and ≤105% of predicted at screening. exclusion criteria: * a g551d, g1244e, g1349d, g178r, g551s, s1251n, s1255p, s549n, s549r, or r117h mutation. * history of any illness or any clinical condition that, in the opinion of the investigator, might confound the results of the study or pose an additional risk in administering study drug to the subject. * ongoing or prior participation in an investigational drug study within 30 days before the screening visit. * protocol-specified abnormal laboratory values at the screening visit * for subjects \<18 years of age at the screening visit, evidence of cataract/lens opacity determined to be clinically significant by the ophthalmologist or optometrist during the ophthalmologic examination (oe) at the screening visit. * use of any moderate or strong inducers or inhibitors of cytochrome p450 (cyp) 3a, including consumption of certain herbal medications and certain fruit and fruit juices, within 14 days before day 1. * pregnant, breastfeeding, or planning to become pregnant during the study. * sexually active subjects of reproductive potential must be willing to use appropriate contraception.
lymphocyte - monocyte ratio as an independent predictor for progression of illness in patients with covid-19

Conditions: Covid19

Summary: corona virus disease 2019 (covid 19), first identified in december 2019 in a cluster of population in a chinese province, soon emerged as a pandemic, causing a huge strain on healthcare system and mortality all over the world. an ideal marker for predicting course of this illness should be easily available and reproducible; as the disease burden has spread to third world countries whose healthcare system is resource limited. our study is aimed to study the utility of lymphocyte- monocyte ratio in the early stages to predict the progression of covid 19 pneumonia.


Eligibility criteria:
inclusion criteria: * all adults of age 18-80 years tested positive for sars-cov-2 reverse-transcriptase - polymerase chain reaction (rt-pcr) and presented within 7 days of symptom(s) onset exclusion criteria: * pregnancy * sepsis * malignancy * patients on immunosuppressant therapy * chronic inflammatory conditions * cases lost to follow up

Keywords: lymphocyte monocyte ratio covid-19 disease progression
effect of positive end expiratory pressure (peep) on cerebral oxymetry during laparoscopy

Conditions: Cerebral Ischemia

Summary: the investigators hypothesized that positive end expiratory pressure (peep) would increase the regional oxygen saturation (rso2).

the investigators hypothesized that peep would increase the rso2 during laparoscopic surgery by improving oxygenation.

Eligibility criteria:
inclusion criteria: * asa ps i or ii adult patient undergoing laparoscopic low anterior resection with trendelenburg position exclusion criteria: * patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index \> 30) were excluded from this study.

Keywords: cerebral oxymetry laparoscopy peep
the effect of laughter therapy in women

Conditions: Migraine; Laughter

Summary: migraine: an episodic disorder consisting of severe headache, usually with photophobia (sensitivity to light), phonophobia (sensitivity to sound), and/or nausea (occasionally vomiting). migraine is predominantly a female disease. the incidence of migraine was found to in women (18.2/1000 person-years) and between the ages of 15-19 in men (6.2/1000 person-years). the incidence of migraine was found to peak between the ages of 20-24 in women (18.2/1000 person-years) and between the ages of 15-19 in men (6.2/1000 person-years). migraine treatments are generally classified as pharmacological (treatment with medication) and non-pharmacological (treatment with no medication). laughter therapy has recently come to the fore as a non-pharmacological and alternative treatment in chronic pain management. in a randomized controlled study, 30 minutes of laughter therapy was applied to women on the 2nd and 6th days after mastectomy surgery and it was determined that women who received laughter therapy had a significant decrease in pain and anxiety levels. this study was planned to determine the effect of laughter therapy on women with migraine.

the research will be carried out with young girls who are studying at the faculty of health sciences of sinop university in the 2022-2023 academic spring semester. inclusion criteria for the research: faculty of health sciences, to study in the 2022-2023 academic spring semester, to have been diagnosed with migraine, to be young girls and to volunteer to participate in the research. exclusion criteria from the study; not studying at the faculty of health sciences and not volunteering to participate in the research. the application and control group will be determined on random.org among the group that constitutes the sample of the study. laughter therapy sessions will be applied online for 25-30 minutes once a week for 2 months by the researcher who has the laughter therapy certificate to the application group. at the end of two months, the personal information form and psychological well-being scale will be administered again to both the application group and the control group.

Eligibility criteria:
inclusion criteria: * being a nursing student, * being a female student, * volunteering to participate in the study. * being a woman * being diagnosed with migraine exclusion criteria: * not to study as a nursing student * being a male student * not to volunteer to participate in the study * not being a woman between the ages of 18 and 30

Keywords: migraine laughter therapy young women
functional and patient-reported outcome after peroneal tendon surgery and different immobilization protocols

Conditions: Tendon Tear; Tendon Rupture; Tendon Injuries; Surgery

Summary: patients with surgery of a peroneal tendon injury in gothenburg, sweden, will be randomized to one of two different postoperative protocols. before and after surgery the patients will perform biomechanical evaluation and also fill out questionnaires including proms. all evaluations will be performed on both limbs.

patients admitted for surgery because of peroneal tendon injury will be randomized to one of two postoperative immobilization protocols. in group a the patients will use a cast for 6 weeks after surgery. in group b, the patients will use a cast for 3 weeks followed by a air stirrup for 3 weeks. the patients in group b will start unloaded range of motion 3 weeks after surgery. both groups are allowed to weight-bear directly after surgery. the patients will be evaluated before and several times after surgery. patient-reported outcome measures (proms) will be used to evaluate changes in patient quality of life between the two interventions. a biomechanical evaluation of the ankle, knee and hip kinematics and kinetics during walking, running and walking will also be performed before and repeatedly after surgery.

Eligibility criteria:
inclusion criteria: \* surgery of peroneal tendon rupture and/or rupture of ligament and/or rupture of retinacle exclusion criteria: * extensive surgery needed, such as for example heel osteotomy * previous surgery in the affected area * previous injury in the healthy foot/leg that impairs function * neuromuscular disease * impaired language comprehension * age under 18
prenatal yoga on stress, quality of sexual life and sleep level

Conditions: Stress; Sexuality; Sleep

Summary: the study will investigate the effects of pregnancy yoga on perceived stress, quality of sexual life and sleep level. a total of 100 pregnant women are planned to be included in the study. data will be collected with the "personal information form", "perceived stress scale" and "sexual quality of life questionnaire-female". yoga will be applied to the experimental group for a total of 12 sessions, two sessions per week (90 minutes) for six weeks. the research predicts that yoga will reduce the stress perceived by pregnant women, increase the quality of sexual life and positively affect sleep patterns.

although pregnancy is a natural process, the change in physiological and psychosocial balance and the differentiation of roles in life require bio-psychosocial adaptation for the pregnant woman and her environment. in addition to strengthening the uterine and perineal muscles and supporting the spine, yoga is effective in dealing with common problems of pregnancy such as poor blood circulation, blood pressure fluctuations, excessive weight gain, fatigue, edema and urinary problems. the study will investigate the effects of pregnancy yoga on perceived stress, quality of sexual life and sleep level. a total of 100 pregnant women are planned to be included in the study. data will be collected with the "personal information form", "perceived stress scale" and "sexual quality of life questionnaire-female". yoga will be applied to the experimental group for a total of 12 sessions, two sessions per week (90 minutes) for six weeks. the research predicts that yoga will reduce the stress perceived by pregnant women, increase the quality of sexual life and positively affect sleep patterns.

Eligibility criteria:
inclusion criteria: * pregnancy week between 24 and 34, * able to read and write turkish, * no communication problems, * those who voluntarily agreed to participate in the research exclusion criteria: * those who have risky pregnancies, * those with diagnosed psychiatric problems, * participating in a different training program (meditation, relaxation, etc.)

Keywords: midwifery perceived stress sexual quality of life sleep pregnancy
regularity of physical activities (regul'aps)

Conditions: Overweight; Obesity

Summary: in french primary schools, children participate in 3 compulsory hours of physical education (pe) each week unless they have a medical contra-indication. but, there is no scientific evidence (randomized trial) that a weekly physical activity splitting up of these 3 hours of pe brings or not the same effects, particularly to prevent overweight or obesity. regul'aps is a cluster randomized controlled trial which wants to evaluate whether splitting up the 3 hours into 3 or 4 sessions (vs. 1-2 sessions) of pe per week has an effect on speed of a bmi increase and on health-related quality of life (hrqol) over the school year. study hypothesis: reduction of speed of increase of bmi and an increase of hrqol


Eligibility criteria:
inclusion criteria: * all teachers under the cover of the headmasters in charge of classes from grades 2 to 5 in 2 counties in the lorraine region of france (meurthe-et-moselle and vosges \[district of golbey\]) * headmasters or teachers had to agree to modify the organisation of pe sessions exclusion criteria: * classes composed only of 2d grade * set schedule of physical educational sessions

Keywords: body mass index health-related quality of life physical education children cluster randomized controlled trial prevention child french schoolchildren
an internet-based information platform for vulvodynia patients

Conditions: Vulvodynia

Summary: vulvodynia is a very common but vastly under-diagnosed and under-treated gynaecological condition that leads to extreme suffering for both the women involved but also their partners. it has also been shown to be associated with poor quality of life, leading to depression and anxiety states. when left untreated, the condition takes a very long time to resolve, with a substantial associated disability and suffering. both psycho-education and internet-based interventions have been shown to be highly successful while they can be quite affordable. this makes them highly cost-effective. the present study aims at evaluating the effectiveness of such an intervention among a vulvodynia patient population from the clinics of uppsala, falun, orebro and gävle. the patients will be recruited by treating physicians and given access to the internet-based platform, where they will fill out questionnaires during four different time-points, after randomization to the control or the intervention group. the intervention group will also have access to multiple activities and information material uploaded in the internet-based platform. differences in pain, quality of life and mental health parameter outcomes will be assessed at the end of the study. should this intervention prove effective, it will be implemented in clinical praxis in the four regions.


Eligibility criteria:
inclusion criteria: * vulvodynia patients at their initial evaluation visit to a physician providing written informed consent for participation in the study exclusion criteria: * inability to read and understand swedish * severe mental illness * currently in treatment for vulvodynia
patient education in pregnant women with asthma

Conditions: Asthma

Summary: pregnancy may impact treatment adherence in women with asthma. this is a major risk factor for asthma exacerbation, which may have an important impact for both women and the babies. this study aims to evaluate the impact of a targeted patient education action tailored for pregnant women with asthma.


Eligibility criteria:
inclusion criteria: * adult pregnant women with asthma exclusion criteria: * women not able to speak and/or read french language * women protected by the law
evaluation of viral replication by tonate virus (tonv) and zika virus (zikv), within an ex vivo trophoblast and placental model

Conditions: Zika Virus Infection

Summary: prospective, non-interventional study carried out after culturing placental trophoblastic tissue ex vivo and infection with zika and tonate

the analysis will relate for each virus studied + control + favipiravir to 1 placenta in the 1st trimester and 1 placenta at term. 2 experiments per virus will be planned.

Eligibility criteria:
inclusion criteria: * patient over 18 years old * singleton pregnancy of normal course, at term, birth by caesarean section or * trophoblast from voluntary termination of pregnancy (ivg), after endo-uterine aspiration exclusion criteria: * need for pathological, genetic or bacteriological examination of the placenta * multiple pregnancy * hbv+ (hepatitis b positive), hcv+ (hepatitis c positive) , known cmv seroconversion during pregnancy (cytomégalovirus) * immunosuppression (drugs, corticosteroids, etc.) * diabetes * pre eclampsia * intrauterine growth retardation (iugr), * vascular or placental pathology. * refusal to participate * patient under guardianship / curatorship / security measure * patient under ame (state medical aid)

Keywords: trophoblast placenta