Kornimate/medical-research-clean huggingface dataset:
lipoic acid supplementation in ivf

Conditions: Women Infertility

Summary: alpha-lipoic acid (ala) is a natural molecule that can make a significant contribution to the success of embryo implantation phase, because it exerts, directly or indirectly, an immunomodulatory activity. ala has the ability to regenerate antioxidants molecules that facilitate embryo implantation, and to stimulate the production of local mediators useful for implantation. this study is a prospective clinical trial and aims to evaluate the reproductive outcomes of italian couples following oocyte donation fresh cycles when receiving per os tablets of lipoic acid. indeed, the control group had only the standard treatment (vaginal progesterone), whereas the study group, in addition to that, received ala (300 mg, 2 times per day) by oral route, from the day of donors oocyte pick up until the pregnancy test. if the childbearing occurred, treatment continued until the 8th week of pregnancy. primary outcome of the study is the implantation rate while the positive hcg rate, the clinical pregnancy rate, the miscarriage rate and the live-birth rate are secondary outcomes .


Eligibility criteria:
inclusion criteria: donors: * proof of fertility; * ⩽32 years old * bmi \<30 kg/m2 * regular menstrual cycles of 25-33 days * two normal ovaries based on transvaginal scan findings. recipients: * women with infertility problems * ⩽50 years old, * bmi \<34 kg/m2 exclusion criteria: donors: * polycystic ovaries * endometriosis * gynaecological or medical disorders. recipients: * endocrinologic problems * medication for chronic illness * azoospermic partner that require tese * sperm donation cycles

Keywords: oocyte donation ivf lipoic acid implantation rate endometrial receptivity
clinical study on diagnostics and outcome of ruptures of the subscapularis after arthroscopic refixation

Conditions: Subscapularis Tendon Rupture

Summary: the purpose of the trial is to optimize the diagnostics of subscapularis tendon tears and as the circumstances require to found a new classification. the prime objective is a comparison of the conclusive of the clinic check-up, the sonographic and magnetic resonance tomography findings. the secondary objective is to detect the correlation of the outcome with the age , the gender, the pathogenesis and attendant injuries.


Eligibility criteria:
inclusion criteria: * patients, who have turned 18 * suspected subscapularis tendon rupture exclusion criteria: * disability to understand the trial * intraoperative intact supbscapularis tendon * pre-surgical operation of the affected shoulder * tumor * infection
a study of remote ischaemic preconditioning in patients with atherosclerosis undergoing vascular surgery

Conditions: Abdominal Aortic Aneurysm; Peripheral Artery Disease; Carotid Artery Stenosis

Summary: the purpose of this study is to evaluate the effect of preoperative remote ischaemic preconditioning (ripc) on organ damage and the functional characteristics of arteries in patients undergoing vascular surgery. in addition, we investigate the connection between ripc and changes in the functional characteristics of arteries and low molecular weight metabolites.


Eligibility criteria:
inclusion criteria: * patients who are willing to give full informed consent for participation and * who are undergoing open abdominal aortic aneurysm repair or * who are undergoing endovascular aortic aneurysm repair or * who are undergoing lower limb revascularization surgery or * who are undergoing carotid endarterectomy exclusion criteria: * patients under age of 18 * patients who are pregnant * patients with known malignancy during last 5 years * patients with permanent atrial fibrillation or flutter * patients with symptomatic upper limb atherosclerosis * patients who require home oxygen therapy * patients with egfr \< 30 ml/min/1.73 m2, measured preoperatively * patients who have had myocardial infarction during last month * patients who have had upper limb vein thrombosis * patients who have undergone vascular surgery in the axillary region * patients who are not able to follow the study regimen

Keywords: atherosclerosis
immediate effect and substantivity of the essential oils without alcohol on the oral biofilm in situ

Conditions: Biofilms; Substantivity; Oils, Essential

Summary: this study aims to evaluate the in situ antibacterial activity of a mouthwash containing essential oils with and without alcohol on undisturbed de novo plaque-like biofilm (pl-biofilm) up to 7 h after its application. an appliance was designed to hold six glass disks on the buccal sides of the lower teeth, allowing pl-biofilm growth. twenty healthy volunteers will the appliance for 48 h and then performed a mouthwash with essential oils. disks will be removed after 30 s and at 1, 3, 5, and 7 h later. after a washout period, the same procedure will be repeated with a sterile water mouthwash and a mouthwash with essential oils without alcohol. after pl-biofilm vital staining, samples will be analyzed using a confocal laser scanning microscope analysing their bacterial viability and thickness.


Eligibility criteria:
inclusion criteria: systemically healthy adults. * minimum of 24 permanent teeth. * no gingivitis (community periodontal index score = 0). * no periodontitis (community periodontal index score = 0). * absence of untreated caries. exclusion criteria: * smoker or former smoker. * presence of dental prostheses. * presence of orthodontic devices. * antibiotic treatment or routine use of oral antiseptics in the previous 3 months. * presence of any systemic disease that could alter the production or composition of saliva.

Keywords: essential oils microscope, colfocal dental plaque
the study on bacterial load following open-to-air management in burn patients.

Conditions: Burns; Infection Wound; Bacterial Infections

Summary: burns are one of the common forms of trauma and are a cause of unintentional death and injury. management of burns becomes complex due to multiple associated complications, for instance, secondary infection of burn wounds is the most common complication associated with burn injuries. treatment of bacterial infections with antibiotics is becoming more challenging due to the development of multidrug-resistance. hence, there is a critical need to investigate and establish non-antibiotic approaches to prevent colonization, control growth, and eliminate bacteria from burn wounds. recent studies have explored the beneficial effects of open-to-air strategies on wound healing. based on the evidence, the investigators hypothesize that bacterial load in burn wounds will be lowered when treated with an open-to-air strategy compared to the traditional closed wound approach.

burns are one of the common forms of trauma and are a cause of unintentional death and injury in the world as well as in the united states (us). management of burns becomes complex due to multiple associated complications, which result in short-term and long-term disability. secondary infection of burn wounds is the most common complication associated with burn injuries. approximately 10,000 people die in the us due to burn-related infections. for instance, gram-negative pseudomonas aeruginosa is an opportunistic organism commonly found in burn wounds. bacterial infections cause prolonged hospital stay, increase morbidity, and mortality of burn patients. treatment of bacterial infections with antibiotics is becoming more challenging due to the development of multidrug-resistance. hence, current antibiotic regimens and wound care are not always successful in eliminating bacterial infections. as such, there is a critical need to investigate and establish non-antibiotic approaches to prevent colonization, control growth, and eliminate bacteria from burn wounds. recent studies have explored the beneficial effects of open-to-air strategies on wound healing, especially in the presence of necrotizing infections. in an open-to air strategy, the wound is left open to the external environment with a heat lamp placed at 6 feet to promote drying. however, the spritz of a topical solution will be applied to avoid excessive drying. based on current evidence, the investigators hypothesize that bacterial load in burn wounds will be lowered when treated with an open-to-air strategy compared to the traditional closed wound approach.

Eligibility criteria:
inclusion criteria: 1. age 18 to 89 2. burn patients with tbsa≥ 20% 3. any suspicion of skin colonization or infection based on a positive result of microbiologic testing. testing would only be performed if the attending surgeon treating the patient had a clinical suspicion of wound infection. exclusion criteria: 1. children
ultrasound and phonophoresis in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: in this placebo-controlled, randomized, prospective study, the efficacy of ultrasonography (us) and steroid phonophoresis (ph) treatments was evaluated in patients with idiopathic carpal tunnel syndrome.

twenty-seven patients (46 hands) were admitted in this study. patients were randomly divided three groups. the first group was ultrasound group, the second group was ph group and the third group was placebo us group. continuous ultrasound with a frequency of 1 mhz, an intensity of 1.0 w/cm2 was used in the us and the ph groups. ph group received 0,1% dexamethasone. placebo group received a frequency of 0 mhz, an intensity of 0 w/cm² ultrasound. treatments were administered for 5 days a week, a total of 10 sessions. all patients also wore night splints during treatment. visual analogue scale (vas), boston symptom severity scale, functional capacity scale, grip strength and electroneurophysiological evaluations were compared before the treatment, after the treatment and three months later.

Eligibility criteria:
inclusion criteria: * mild or moderate idiopathic carpal tunnel syndrome (without thenar atrophy or spontaneous activity on electrophysiological examination of the abductor pollicis brevis (apb) muscle) exclusion criteria: * the patients with medical problems (diabetes mellitus, hypothyroidism, rheumatic diseases, acute trauma, pregnancy etc.) * cervical radiculopathy * etiologic factors which predispose to or polyneuropathy * reinnervation or fibrillation potentials in their abductor pollicis brevis muscles * physical or medical therapy within 3 months for cts and steroid injection applied * experience cts median nerve trauma and cts surgery * serious thenar atrophy and anesthesia * contraindication in steroid treatment (steroid allergies, hypertension etc.) * contraindication in ultrasonic therapy (bleeding disorders, acute inflammation of the joints, acute infections, cancer and precancerous lesions, arteriovenous circulatory disorders etc.)

Keywords: carpal tunnel syndrome steroid phonophoresis ultrasound
cardiopulmonary interactions in patients with heart failure

Conditions: Heart Failure; Pulmonary Hypertension; Heart Failure With Reduced Ejection Fraction; Heart Failure With Normal Ejection Fraction

Summary: this study aims to evaluate cardiopulmonary interactions in patients with heat failure

heart failure is one of the most common diseases, especially in ageing populations, affecting ≥10% of persons 70 years of age or older. there is a growing body of evidence that dyspnea in patients with heart failure is not only related to low cardiac output and pulmonary venous congestion, but also to functional and structural alterations of the lungs.pulmonary hypertension is a well-known complication of heart failure, but recent evidence suggests that the alveolo-capillary membrane is also affected, at least in subgroups of patients with heart failure. damage to the alveolo-capillary membrane is reflected by a low diffusion capacity of the lungs for carbon monoxide (dlco). in this study we aim to describe the alteration of lung function and obtain morphometric data of the capillary bed of patients with heart failure.

Eligibility criteria:
inclusion criteria * written informed consent prior to initiation of any study-mandated procedures * male or female ≥40 years at screening * confirmed diagnosis of hfpef (heart failure with preserved ejection fraction), hfmref (heart failure with mid range ejection fraction) or hfref (heart failure with reduced ejection fraction) in new york heart association (nyha) functional class ii, iii or iv exclusion criteria * significant lung disease according to the judgment of the investigator; as a rule, the total lung capacity (tlc) should be \>70% of the predicted value and the forced expiratory volume in 1 second (fev1) should be \>60% of the predicted value * significant co-morbidities expected to limit life expectancy to less than 2 years, according to the judgment of the investigator
effect of posture on left ventricular (lv) transvenous lead capture thresholds (expect)

Conditions: Congestive Heart Failure

Summary: the purpose of this study is to determine whether changes in a patient's position affect lv capture thresholds in a clinically significant way.

traditionally clinicians program the safety margins for the right atrial, right ventricular, and left ventricular leads two-times the capture thresholds. this safety margin is necessary for the right atrial and right ventricular outputs to prevent asystole during fluctuation of capture thresholds. this two-times safety margin may not be necessary for the left ventricular lead output and may be causing shorter device battery longevity. newly implemented lv capture threshold management algorithms may help maintain a proper balance of safety margin and battery longevity. however, recent research conducted on automatic left ventricular capture measurement (lvcm) shows as much as 3.5 v daily variability in capture thresholds. in this same study, 18% of patients had \>1.5 v lv threshold variability. a possible explanation for the variability of lv thresholds is lead stability. small movements of the lead electrodes associated with movement of patient posture may account for daily fluctuation of capture thresholds. as heart failure patient care and therapies improve, crt patients may survive longer than the projected longevities of their device. in order to minimize patient risks associated with device change-outs, care must be taken to maximize battery longevity while maintaining crt pacing. examining patient posture changes as a possible cause of threshold variability may guide clinicians to program more appropriate lv outputs with patient safety and device longevity in mind.

Eligibility criteria:
inclusion criteria: * greater than 18 years of age and able to provide informed consent * planned placement of a medtronic lv pacing lead and a medtronic icd generator with lvcm technology * geographically stable and able to follow-up for a period of at least six months post-procedure at the heart hospital baylor plano * willingness to comply with the requirements of the protocol exclusion criteria: * life expectancy of less than six months * plans for or significant possibility of pregnancy during the required follow-up window * significant cardiovascular surgery planned within six months following icd implant

Keywords: congestive heart failure (chf) cardiac resynchronization therapy (crt) biventricular implantable cardioverter defibrillator (bivicd) fraction
a study of apatinib in combination with raltitrexed treatment in patients with advanced colorectal cancer

Conditions: Colorectal Cancer

Summary: 30 patients with advanced colorectal cancer will be enrolled to observe the efficacy and safety of raltitrexed combined with apatinib as a third-line treatment.

in this study, we plan to enroll 30 patients with advanced colorectal cancer after failure of second-line standard chemotherapy. the therapeutic regimen is raltitrexed, 3 mg/㎡, ivgtt, d1, apatinib 500 mg, qd,po, d1-21, every 3 weeks for 1 cycles, the primary end point was pfs, the secondary end point was os, dcr, orr etc. aim to observe the efficacy and safety of raltitrexed combined with apatinib as a third-line treatment of in patients with advanced colorectal cancer.

Eligibility criteria:
inclusion criteria: * 1.male or female, ≥ 18 of age; * 2.histological confirmed advanced colorectal adenocarcinoma，and at least one measurable lesion; * 3.have failed for ≥ 2 lines of standard chemotherapy(included fluorouracil, irinotecan and oxaliplatin); * 4.ecog performance status 0-2; * 5.life expectancy of more than 3 months; * 6.the main organs function is well, and randomized within 14 days before the relevant inspection indicators to meet the following requirements: 1. blood routine test hgb ﹥90g/l, anc﹥1.5×109/l, platelets ﹥ 100×109/l, 2. biochemical tests serum total bilirubin ≤ 1.5 x unl(upper normal limit), alt or ast ≤ 2 xunl, and ﹤ 5 x unl（hematogenous metastases）, creatinine clearance rate≥ 60 ml/min(cockcroft-gault formula), 3. doppler echocardiography assessment：lvef ≥ 50%; * 7.no serious heart, lung, liver, kidney dysfunction; no jaundice and gastrointestinal obstruction; no acute infection; * 8.signed informed consent; * 9.good compliance, and family members agree to receive survival follow-up. exclusion criteria: * 1.factors that could have an effect on oral medication (such as inability to swallow, chronic diarrhea and intestinal obstruction);

Keywords: third-line treatment apatinib raltitrexed
artificial intelligence in lung ultrasound for preeclampsia

Conditions: Preeclampsia; Lung Edema

Summary: a total of eight quadrants of standard lung us examination was performed to all pregnant women with preeclampsia within the scope of the study by the same anesthesiologist, dividing each hemithorax into four regions through the parasternal, anterior axillary, posterior axillary vertical lines, and the horizontal line assumed to pass under the nipple. the resulting images were stored in digital media. a lung us examination was performed once for an average of 5-10 minutes. the presence of b lines was investigated in the examination. the case was defined as interstitial edema when the b lines, which are defined as vertical linear hyperechoic reverberation artifacts representing the edematous interlobular septa/alveoli, extend posteriorly from below the pleural line and moving in sync with lung movements, are found in two or more lung areas. b-lines were determined for each case and reported in standard form in terms of number and morphology. the diagnostic accuracy of b lines was determined with the artificial intelligence supported smartalpha rievi 1300 software program. b-lines validated by artificial intelligence assisted algorithm in all stored digital images were reported blindly by another anesthesiologist experienced in lung us. the clinical features, laboratory parameters, and intraoperative hemodynamic data of the cases were recorded to be evaluated in terms of relationship with lung us data. we predict that the application of lung us with artificial intelligence software will provide an opportunity to quickly evaluate the clinic of preeclamptic pregnant women who are frequently operated on in emergency conditions.

after ethics committee approval, standard lung ultrasound (us) examination in eight quadrants was performed to search presence of b lines in 35 asa iii-iv parturients with preeclampsia by the same anesthesiologist. interstitial edema was defined by recognition of the b lines in two or more lung regions. the digital images of b-lines verified with artificial intelligence (ai) were evaluated blindly by another anesthesiologist experienced in lung us. after assigning preeclamptic patients as mild or severe; demographic, hemodynamic and labarotary results were compared. then, lung us findings (a pattern, 3 b lines and 1 or 2 b lines) were documented. additionally, amount of protein / 24 hr, amount of fluid infusion (crystalloid or colloid) and hemodynamic parameters acording to lung us findings were compared.

Eligibility criteria:
inclusion criteria: * pregnant women who underwent cesarean section with a diagnosis of preeclampsia exclusion criteria: * preeclamptic parturients who have another lung disease * preeclamptic parturients whose optimal lung us image could not be obtained

Keywords: preeclampsia lung ultrasound artificial intelligence
study evaluating safety and efficacy of incb050465 combined with bendamustine and obinutuzumab in relapsed or refractory follicular lymphoma (citadel-102)

Conditions: Lymphoma

Summary: the purpose of this study is to evaluate the safety and efficacy of parsaclisib when combined with bendamustine and obinutuzumab in subjects with relapsed or refractory follicular lymphoma (fl).


Eligibility criteria:
inclusion criteria: * histologically confirmed fl. * documented cd20+ fl. * relapsed or refractory to any prior rituximab-containing regimen. * previously treated with a maximum of 4 cancer-directed treatment regimens. * at least 1 measurable lesion \> 1.5 cm in at least 1 dimension by computed tomography or magnetic resonance imaging. * must be willing to undergo an incisional or excisional lymph node biopsy of accessible adenopathy or provide the most recent, available archived tumor biopsy. * eastern cooperative oncology group (ecog) performance status of 0 to 2. exclusion criteria: * clinical evidence of transformation to a more aggressive subtype of lymphoma or grade 3b fl. * history of central nervous system lymphoma (either primary or metastatic). * allogeneic stem cell transplant within the last 6 months, or active graft-versus-host disease following allogeneic transplant or autologous stem cell transplant within the last 3 months before the date of the first dose of study drug administration. * use of any potent cytochrome p450 3a4 inhibitors or inducers within 14 days or 5 half-lives (whichever is longer) before the first dose of study drug. * prior treatment with a selective pi3kδ inhibitor or a pan pi3k inhibitor. * prior treatment with bendamustine (within 12 months of the start of study treatment). subjects with prior bendamustine treatment (\> 12 months before the start of study treatment) are eligible if they meet the following criteria: * did not discontinue because of tolerability concerns. * achieved either partial or cr to the bendamustine regimen of at least 12 months in duration before relapse/progression. * experienced progression following a regimen containing an alkylating agent. * received prior obinutuzumab. * received rituximab within 4 weeks of study start. * prior treatment-related toxicities that have not resolved to ≤ grade 1 before the date of study drug administration except for stable chronic toxicities (≤ grade 2) not expected to resolve (eg, stable grade 2 peripheral neurotoxicity). * received any prior monoclonal antibody (except an anti-cd20 antibody) within 90 days before the date of study start. * history of severe allergic or anaphylactic reactions to monoclonal antibody therapy (eg, subjects in whom re-administration with rituximab would be contraindicated for safety reasons).

Keywords: follicular lymphoma relapsed refractory non-hodgkin lymphoma phosphatidylinositol 3-kinase (pi3k)