Kornimate/medical-research-clean huggingface dataset:
project self in improving cervical cancer screening rates in hispanic and african american women

Conditions: Healthy Subject

Summary: this trial studies if project self can improve the rate of cervical cancer screening in hispanic and african american women living in houston, texas. project self may help to improve cervical cancer screening rates by providing human papillomavirus (hpv) self-collection kits, education, counseling, and navigation.

primary objectives: i. to examine the feasibility of conducting an education intervention trial regarding cervical cancer screening among women of hispanic and african american origin living in public housing units in houston, texas. secondary objectives: i. document cervical screening associated knowledge, attitudes and practices among hispanic and african american women living in public housing units in houston, texas at pre- and post-health education. ii. document pap smear screening rate in last 3 years among participants. iii. document hpv positive rate among participants. outline: participants complete questionnaires, take part in a health education session, and receive an hpv self-collection kit. after completion of study, participants are followed up at 1 month.

Eligibility criteria:
inclusion criteria: * self-identify as african american or hispanic women. * valid home address reflective of residence in the participating housing development(s) at least 50% of the time. * functioning telephone number. * speak and read english or spanish. exclusion criteria: * self-reported hysterectomy. * self-reported personal history of cancer/cancer diagnosis. * self-reported as pregnant. * another household member is enrolled in this protocol.
performance of pulmonary embolism risk scores out come in ctpa confirmed patients

Conditions: Pulmonary Embolism

Summary: 1. assess performance of perform score in predicting outcome in ctpa confirmed patients. 2. compare perform score with the currently validated pesi in risk stratification of patients

pulmonary embolism (pe) is a common and potentially lethal condition in the emergency department requiring early and accurate management. the short-term mortality rate of pe varies widely and ranges from less than 2% in many patients with non massive pe to more than 95% in patients who experience cardiorespiratory arrest. although several prognostic models of acute pe are currently used, all of them have practical limitations. of all clinical scores integrating pe severity and comorbidity, the pulmonary embolism severity index (pesi) and its simplified version,(spesi) have been most extensively validated to date. however, current prognostic scores for pulmonary embolism (pe) are partly based on patients without pe confirmation via computed tomographic pulmonary angiography (ctpa), involving subjective parameters and complicated scoring methods \[8\]. therefore, an objective, accurate, and simple prognostic model in ctpa-confirmed patients to predict the risk of 30-day mortality. help clinicians assess patients' risks and improve therapeutic decision-making that is called perform score (pulmonary embolism risk score for mortality)

Eligibility criteria:
inclusion criteria: - patients above 18 years old with pe confirmed by ctpa are considered for inclusion in the study. exclusion criteria: * • patients who have contraindications for ctpa eg. renal impairment * patients diagnosed and treated as pe without doing ctpa. * patients who refuse to participate in the study
antibiotic misuse during covid-19 pandemic

Conditions: Covid19

Summary: evaluating the important role of the community pharmacists in pandemics like covid-19 and to find whether there was a misuse of antibiotics during the pandemic or not and to define the reasons behind this misuse if any present.

community pharmacy in egypt is considered as the frontline health care system that is easily and freely accessible by the patients, in this pandemic and due to the current circumstances from closing most general hospitals in front of the public, and with the government applying curfew long hours, community pharmacists were the only healthcare providers available for most patients. their role will not be restricted to delivering medication but expands to monitoring patient conditions especially those with chronic diseases and patient counseling and education clarifying any misunderstanding concerning covid1-19 medication. the present study includes a questionnaire (with detailed questions including how/when/which/for how long antibiotics are prescribed) that is addressed for community pharmacists who dealt with covid-19 patients during the pandemic.

Eligibility criteria:
inclusion criteria: * all community pharmacists worked during the pandemic and dealt with covid-19 patients inside their pharmacies are welcomed to participate exclusion criteria: * clinical and hospital pharmacists- other medical staff- pharmacist assistant

Keywords: coronavirus observational survey antibiotics egypt
eus share-wave in patients with liver cirrhosis

Conditions: Liver Cirrhosis

Summary: patients with chronic liver disease may develop progressive hepatic fibrosis. liver cirrhosis should be detected at the early stages in order to avoid the complications related to these two conditions. the diagnostic work-up of patients with chronic liver disease includes less-invasive diagnostic methods such as abdominal ultrasonography, transient elastography, upper endoscopy; and more invasive procedures, mainly liver biopsy and portal pressure gradient measurement, both with associated risks. endoscopic ultrasound offers a benefit of including all diagnostic work-up in a single procedure. the investigators previously demonstrated that eus-elastography of the liver and spleen is reliable marker for predicting liver cirrhosis. recently, a quantitative evaluation of fibrosis using share wave elastography was introduced, mainly for the pancreatic tumor fibrosis measurement (2). elastography measures the elasticity of tissues (hardness); whereas share wave measures the tissue elasticity as the elastic modulus by measuring the share wave velocity. share wave measurement will be performed with the arietta 850 endoscopic ultrasound console using a linear ultrasound video gastroscope eus-j10 (pentax medical, hoya corp, japan). the investigators proposed the eus-share wave of the liver as a reliable diagnostic marker in patients with liver cirrhosis.

a non-blinded, prospective trial. primary disease condition: liver cirrhosis keywords: liver cirrhosis; fibrosis; endoscopic ultrasonography; elasticity imaging, tissue. study design: observational study model: a non-blinded, non-randomized, prospective trial time perspective: prospective enrollment type: actual number of subjects: 16 participants number of groups/cohorts: 2 cohorts target follow-up duration: 6 months based on the proportion of patients with the liver strain histogram (lsh) \>87.40 among cirrhosis (87.5%) and control cases (31.0%) described by robles-medranda et al. (1), the investigators calculated eight patients per study group with a 5% and 20% of alpha and beta error respectively, with an 80% of power statistic.

Eligibility criteria:
inclusion criteria: * provided informed written consent * age greater than 18 years of age * confirmed diagnosis of chronic liver disease based on transient elastography * patients with eus-guided liver biopsy exclusion criteria: * history of uncontrolled coagulopathy * contraindications to eus-guided liver biopsy * pregnancy or nursing * history of hepatocellular carcinoma * patients with equivocal transient elastography results

Keywords: liver cirrhosis; fibrosis endoscopic ultrasonography elasticity imaging, tissue
far infrared irradiation for stroke rehabilitation

Conditions: Stroke

Summary: a stroke is a sudden loss of brain function. it is caused by the interruption of flow of blood to the brain (ischemic stroke) or the rupture of blood vessels in the brain (hemorrhagic stroke). this study will investigate the use of far infrared radiation for stroke rehabilitation.

a stroke is a sudden loss of brain function. the interruption of blood flow or the rupture of blood vessels causes brain cells (neurons) in the affected area to die. the effects of a stroke depend on where the brain was injured, as well as how much damage occurred. a stroke can impact any number of areas including your ability to move, see, remember, speak, reason and read and write. it is hereby postulated that irradiation using far infrared, with wavelength between 5 to 20 microns, of the central nervous system, the endocrine system and the whole body could prevent, control, manage or possibly lead to complete rehabilitation of people with stroke.

Eligibility criteria:
inclusion criteria: * people with stroke exclusion criteria: * none

Keywords: apoplexy cerebral stroke cerebrovascular accident cerebrovascular accident, acute cerebrovascular apoplexy cerebrovascular stroke
blood products in cardiac surgery

Conditions: Anemia; Renal Impairment; Thrombocytopenia

Summary: blood transfusion is a common procedure essential for the treatment of patients undergoing cardiac surgery. inappropriate transfusions, however, not only incur needless healthcare costs, but increase unnecessary risks due to transfusion reactions and infectious and immunomodulative causes. safe and appropriate patient care requires evaluated blood component prescription practices. practically all patients undergoing cardiac surgery in finland have a blood product booking from the finnish red cross blood service. this registry contains large volumes of transfusion-related information on all finnish patients undergoing cardiac surgery in finnish centers. participating hospitals were scattered to all geographical areas in finland and concentrated to the most populated regions. data on the blood product use, laboratory findings one month pre-operatively and 12 months post-operatively were available. finnish hospitals have been required to provide information on hospital visits for the finnish national research and development centre for welfare and health for healthcare planning purposes. we used in part the original data sent by hospitals to the finnish hospital discharge register (fhdr).

registry includes * \>21 000 patients who underwent coronary bypass, * \>4500 patients with aortic valve replacement, * \>4000 mitral valve operation.

Eligibility criteria:
inclusion criteria: * cardiac surgery performed in finnish university and central hospitals * blood product booking for surgery exclusion criteria: -

Keywords: anemia renal impairment thrombocytopenia anticoagulation coronary bypass aortic valve surgery mitral valve surgery red blood cell platelet fresh frozen plasma octaplas
a trial to assess the antipsychotic efficacy of iti-007 over 6 weeks of treatment

Conditions: Schizophrenia

Summary: the study will evaluate the antipsychotic efficacy of iti-007 in a randomized, double-blind, parallel-group, placebo- and active-controlled, multi-center study in patients diagnosed with schizophrenia having an acute exacerbation of psychosis.


Eligibility criteria:
inclusion criteria: * male or female subjects of any race, ages 18-60 inclusive, with a clinical diagnosis of schizophrenia * experiencing an acute exacerbation of psychosis exclusion criteria: * any subject unable to provide informed consent * any female subject who is pregnant or breast-feeding * any subject judged to be medically inappropriate for study participation
non elective vulnerable elderly radiotherapy

Conditions: Squamous Cell Carcinoma of Head and Neck

Summary: to evaluate whether patients defined "non-fit for curative non-surgical radio-chemotherapy" and therefore treated with rt alone addressed only to non-elective sites of disease, could obtain a non-inferior loco-regional control compared to similar historical cohorts.

the current standard approach for head and neck malignancies cannot be considered the gold standard for elderly patients, except in carefully selected cases. given the relevance of this population, scientific societies also suggest to propose prospective studies for this subset of frail patients (european organization for research and treatment of cancer (eortc), european society for medical oncology (esmo)). in addition, it is necessary to collect data on specific categories, which are as homogeneous as possible. therefore, the purpose of this study is to evaluate efficacy and safety of a tailored rt approach administered with a curative intent in a subset of frails elderly patients not candidates neither to standard concurrent rt-ct / rt-cetuximab nor to palliative treatment/best supportive care.

Eligibility criteria:
inclusion criteria: * locally advanced non-metastatic hnscc patients older than 70 years * primary tumor clinically and radiologically detectable and measurable (staging according to ed. tnm vii and also viii. * patients defined by the tumor board (ent, oncologist, radiotherapist, nutritionist) as 1) not eligibles for rtct / rt-cetuximab treatment 2) not amenable to radical surgery and 3) not candidates for treatments with palliative intent/best supportive care * availability of staging with ct/pet for distant metastasis and ct/mri for primary tumor * karnofsky performance status (kps) ≥60/100 * oropharynx , hypopharynx and larynx, oral cavity: stage iii and iv and unknown primitive p16-positive exclusion criteria: * age less than 70 years * staging exams done 45 days before the date of the beginning of the treatment * subsites: nasopharynx, salivary glands, paranasal sinuses. metastatic disease * gross total excision * all subsites concerned if n3. * squamous cell neoplasms of the glottic larynx t1-t2 n0. * unknown primary hpv negative or ebv positive. * presence of distant metastases or sub-clavicular lymphadenopathies. * previous surgery on t and/or n except diagnostic tonsillectomy. * 3d-conformational radiotherapy technique

Keywords: elderly vulnerable radiotherapy non-elective radiotherapy
the effect of the hydroxyethyl starch on kidney injury in pediatric cardiac surgery

Conditions: Acute Kidney Injury

Summary: the investigator will evaluate the influence of colloid administration on postoperative acute kidney injury in pediatric patients undergoing cardiac surgery under cardiopulmonary bypass.

the investigator will randomly divide pediatric patients aged less than 7 years old into crystalloid and colloid groups. crystalloid group receive only crystalloid, and colloid group receive hydroxyethyl starch (hes, 130/0.4). the maximum volume of hes is limited less than 30 ml/kg. the same transfusion protocol will be applied in both groups. from the day of operation to postoperative 7 days, glomerular filtration rate (gfr), serum creatinin level (cr) will be checked. acute kidney injury (aki) is defined when there is more than 50% increase in cr when compared to baseline level. the investigator will compare the clinical outcomes including aki between two groups.

Eligibility criteria:
inclusion criteria: * children aged less than 7 years old * american society of anesthesiology (asa) physical status 1-3 exclusion criteria: * preoperative creatinine \> 1.5mg/dl * history of dialysis * liver function abnormality * diabetes mellitus * history of allergic reaction * coagulation abnormality

Keywords: crystalloid colloid children infant cardiac surgery
mimicking slipping responses using a novel mechanical perturbation algorithm

Conditions: Gait, Stumbling; Gait, Perturbation

Summary: healthy subjects will be invited to fill out a questionnaire regarding falls and balance skills followed by normal walking trials on a treadmill at 9 different speeds (0.28-1.4 m/s). key gait parameters for the normative database will be collected. during the perturbation trials, the subjects will walk at a constant speed (1.2 m/s). the treadmill belts are ac, - or decelerated during the perturbations according to three different perturbation algorithms with varying perturbation onset. movements will be analyzed by 3d motion capture, force plates, surface electromyography and imu sensors. all methods are non-invasive and commonly used in the field of biomechanics.


Eligibility criteria:
inclusion criteria: * healthy subjects aged 18-40 years and 60-80 years * ability to walk at minimum 30 minutes at a regular pace without assistance or breaks * written informed consent as documented by signature (see informed consent form) exclusion criteria: * women who are pregnant or breast feeding * current neurological problems affecting walking function and balance * current orthopedic problems affecting upper and lower extremity movements * history of alcohol abuse or the intake of psychotropic drugs * history of major cardiac condition (e.g., infarction, insufficiency (nyha ii-iv)) * history of major pulmonary condition (e.g., chronic obstructive pulmonary disease (gold ii-iv)) * current major depression or psychosis * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia * fever of unknown origin
immunogenicity, safety of gsks tdap vaccine boostrix when coadministered with gsks influenza vaccine fluarix in adults

Conditions: Acellular Pertussis; Diphtheria; Tetanus

Summary: the current study will provide information for the use of boostrix concomitantly with influenza vaccine in adults aged 19-64 years. this study will also provide safety and immunogenicity data in a cohort of adults aged greater than or equal to 65 years.


Eligibility criteria:
inclusion criteria: * healthy male or female adults aged between 19 to 64 years, inclusive for the primary cohort), or aged 65 years or older (for the exploratory cohort), at the time of vaccination. exclusion criteria: * administration of an influenza vaccine within six months prior to study entry * administration of a diphtheria-tetanus (td) booster within the previous 5 years. * administration of a tdap vaccine at any time prior to study entry. * administration of any investigational or non-registered drug or vaccine other than the study vaccines within 30 days preceding vaccination, or planned use during the entire study period. * history of diphtheria and/or tetanus and/or pertussis disease. * history of serious allergic reaction (e.g. anaphylaxis) following any other tetanus toxoid, diphtheria toxoid or pertussis-containing vaccine or influenza vaccine or any component of the study vaccines.

Keywords: immunogenicity, influenza co-administration, tdap,
swiss prospective autologous bone flap resorption study

Conditions: Brain Edema

Summary: the complications after reimplantation of cryoconserved autologous bone flaps are reported inhomogeniously in the literature. especially the incidence of bone flap resorption varies from 0% to about 30%. more recent retrospective studies seem to find higher resorption rates and thus suggest to implant artificial bone replacements from the start. the swiss prospective autologous bone resorption study is the first propspective observational study designed to determine the true incidence of autologous bone resorption.

patients undergoing decompressive craniectomy and delayed reimplantation of the cryoconserved autologous bone flap are included in a clinical and image-based follow-up to identify cases and severity of bone flap resorption. the explanted autologous bone flaps are cryoconserved and reimplanted at a time-point defined by the surgeon according to standards of the participating hospital. the fixation of the bone flap is also performed according to the surgeon's decision. a cranial ct is performed within one week after reimplantation to define a baseline. a second, only clinical, follow-up will take place within 2 months after reimplantation. two more follow-ups including photodocumentation of the cranial and facial symmetry (portrait and profile) and cranial ct will take place 12 and 24 months after reimplantation. the indication for surgical revision in case of bone flap resorption is independent from the study and falls under the responsibility of the treating surgeon.

Eligibility criteria:
inclusion criteria: * all patients after hemicraniectomy or bifrontal craniectomy * age 18-99 y/o * ability to understand and sign informed consent (alternatively, legal representative may sign) exclusion criteria: * bone flap not fit for reimplantation * no cryoconservation performed but other technique * pregnancy * patient's death

Keywords: autologous bone flap decompressive craniectomy malignant brain swelling patient specific implant bone resorption aseptic bone necrosis
multi-scale analysis of physiological brain networks

Conditions: Epilepsy

Summary: the seeg implantation is performed on purely clinical criteria for preoperative diagnosis. magnetoencephalography and eeg are purely passive techniques that do not involve any additional risk. this project is a continuation of an existing project in which it was demonstrated the feasibility of simultaneous seeg and meg/eeg recordings.

brain function is based on the communication between sets of neurons at different spatial and temporal scales. the dysfunction of these networks is thus at the origin of several brain pathologies, including epilepsy. the recent improvement in recording methods paves the way for better characterization of brain networks, with several spatial and temporal resolutions, depending on the techniques used. still, several key points remain outstanding. first, several mechanisms can underlie the interaction between brain regions, and it remains to determine the most relevant tools in practice to quantify them. second, there are difficulties in extracting these networks from surface recordings. the best strategies for studying these interactions in a non-invasive way therefore remain to be defined. it will be propose to answer these questions based on simultaneous surface (magneto-encephalography/ electroencephalography) and depth (intracerebral stereotactic eeg, seeg) recordings, a technique it was developed by the team of marseille, in patients undergoing preoperative epilepsy assessment. the primary objective is to find, among all the mechanisms of interaction between brain regions, which are most relevant in describing physiological and pathological brain networks. the secondary objective is to test whether the visible coupling information at depth can be found from surface data (eeg, meg) only. to do this, it will be compare the surface results with the seeg results. the seeg implantation is performed on purely clinical criteria for preoperative diagnosis. magnetoencephalography and eeg are purely passive techniques that do not involve any additional risk. this project is a continuation of an existing project in which we have demonstrated the feasibility of simultaneous seeg and meg/eeg recordings.

Eligibility criteria:
inclusion criteria: * inclusion criteria for patients * patients for whom intracerebral electrode implantation is in progress as part of the pre-surgical evaluation of their drug-resistant partial epilepsy. * patient informed, expressing his non-opposition (or legal representative (s), affiliated to a social security scheme * the medical examination is carried out as part of the medical follow-up of these patients * inclusion criteria for control subjects • informed subject, expressing his non-opposition or legal representative, affiliated to a social security scheme * exclusion criteria: minors under 12 years * pregnant or lactating women, * the adults under guardianship or under the protection of justice * non-beneficiaries of a social security scheme * persons deprived of their liberty by a judicial or administrative decision * absence of informed consent

Keywords: meg eeg seeg