Kornimate/medical-research-clean huggingface dataset:
screening of children in household contact with adult tb patients in mbarara hospital, uganda

Conditions: Tuberculosis

Summary: the proposed study aims to establish a pilot program through a prospective cohort study offering routine contact tracing, investigation and prophylaxis for ltbi, and treatment of tb disease to children \<5 years living in the same household as adults diagnosed with smear/culture-positive pulmonary tb in mbarara regional referral hospital

because children with tuberculosis (tb) are usually smear-negative and therefore less infectious, they are generally not considered a public health risk. up to 70% of children living in the same household with an adult with infectious tb will become infected, and more than 20% of them will develop active tb disease, usually within 12 months. the individual risk of developing disease once infected is highest in children \ 50% of the total population being children) suggests that the number of childhood tb cases is probably higher than current hospital records indicate. the proposed study aims to establish a pilot program through a prospective cohort study offering routine contact tracing, investigation and prophylaxis for ltbi, and treatment of tb disease to children \<5 years living in the same household as adults diagnosed with smear/culture-positive pulmonary tb in mbarara regional referral hospital. the study will also generate much needed data on the utility of simple symptom-based screening of child contacts for tb disease in areas where access to radiological examination and tuberculin skin test are limited and on the efficacy and safety of ipt, in a region with a significant problem of hiv co-infection. children aged 1 month to 5 years living in the same household (a house or cluster of houses on the same plot) with a newly diagnosed adult case of smear and/or culture-positive tb will be eligible for the study. children will undergo a physical examination, chest xray, tuberculin skin test and specimen collection in case of symptoms. children will then be classified as active tb, tb infected and non infected cases. tb infected and non infected children will receive 6 months isoniazid prophylaxis with monthly monitoring of acceptability and tolerability. a final clinical assessment will be performed at 9 months. a total of 577 children contacts will be enrolled.

Eligibility criteria:
inclusion criteria: * any child who has lived in the same household with the index case continuously for at least 2 weeks within the 3-month period immediately preceding the diagnosis of smear- positive or culture-positive tb in the index case. * informed consent signed by the parent or legal guardian * living within a 2-hour radius of mbarara town exclusion criteria: * child currently receiving anti-tuberculosis treatment * child has received a full course of anti-tb treatment within the last 6 months

Keywords: contact
improving secretion of insulin in new onset diabetes after renal transplantation

Conditions: New Onset Diabetes Mellitus After Renal Transplantation

Summary: new onset diabetes after transplantation (nodat) is a frequent and feared complication after kidney transplantation and leads to an increase in cardiovascular complications as well as in the rate of graft loss. very little data exist on how patients in which nodat has been diagnosed should be treated. it is suspected that cylosporine a (sandimmun, tm) is less diabetogenic than tacrolimus (prograf, tm). furthermore, it has been described that early initiation of insulin treatment in diabetes mellitus type 2 can preserve and improve the function of the insulin secreting cells in the pancreas. therefore, the investigators test the effects of conversion from tacrolimus to cyclosporine a in patients with newly diagnosed nodat who have just started early treatment with insulin. the hypothesis is that patients who are treated with insulin and who are switched to cyclosporine a have improved glucose metabolism compared to patients who are treated with insulin and who remain on tacrolimus therapy.


Eligibility criteria:
inclusion criteria: * newly diagnosed nodat defined by pathologic ogtt (2h, 75mg glucose): glucose ≥ 200mg/dl * defect in insulin secretion as judged by ogtt and homa b * renal transplantation (deceased or living donor) and treatment with the standard immunosuppression at our center, consisting of tacrolimus, mycophenolate mofetil, prednisone triple therapy without any induction * stable graft function for more than 3 months post transplant * informed consent of the patient exclusion criteria: * patients with prior history of type 1 or type 2 diabetes * time since transplantation more than 20 years * allergy against long-acting insulin or cyclosporine a * body mass index (bmi) \> 35 * pregnancy

Keywords: nodat kidney transplantation beta cell function insulin tacrolimus cyclosporine a
post marketing surveillance study to observe safety and efficacy of inlyta in south korea

Conditions: Advanced Renal Cell Carcinoma

Summary: the objective of this study is to monitor the usage of inlyta® in real practice, including the adverse events associated with inlyta®.

investigators can choose any patient who is within the scope of i/e criteria

Eligibility criteria:
inclusion criteria: * patients diagnosed as advanced rcc after failure of one prior systemic therapy. exclusion criteria: * any patient who does not agree that pfizer or companies working on behalf of pfizer can use his/her information. * patients with hypersensitivity to axitinib or to any other component of inlyta® . * patients under 18. * pregnant women.

Keywords: korean pms of axitinib metastatic rcc ; 2nd line only
pepsin as a biomarker for aspiration

Conditions: Aspiration; Gastroesophageal Reflux

Summary: evaluation of tracheal pepsin as a biomarker for aspiration

aspiration is well recognized in children who have chronic lung disease or who are intubated. there is a known association between gastroesophageal reflux (ger) and aspiration. the distinction between aspiration of swallowed material, such as food and the aspiration of refluxed gastric contents is important. determining whether an aspiration syndrome in an individual is due to ger may be difficult. the most widely used test to determine whether ger is the cause of aspiration involves staining bronchoalveolar lavage (bal) fluid for lipid laden macrophages (llm) based on the hypothesis that refluxed and aspirated fluid is phagocytosed by tracheal macrophages. pepsinogen is a protein unique to gastric chief cells and also requires acidic conditions for activation. therefore the presence of pepsin in bal fluid should only be found when gastric fluid is aspirated. in previous studies, pepsin has been detected in the tracheal fluid of children with chronic lung disease. thus far, studies of this material have been small, not all have control groups, and llm were not looked for in all studies. based on previous studies and the need to improve diagnostic methods, the following aims are proposed: 1. to determine the frequency of pepsin contamination of children without chronic respiratory disease undergoing elective surgery with intubation 2. to determine frequency of tracheal pepsin and lipid laden macrophages (llm) in children with chronic respiratory disease or symptoms and in children with tracheostomies 3. to compare the presence or absence and concentration of pepsin to the presence of llm 4. to relate the presence or absence and concentration of pepsin to clinical status to achieve these aims, bal fluid will be obtained from subject patients and controls. these fluids will be transported to the research lab and stored on ice until analysis. determination of llm will be done in children undergoing diagnostic bronchoscopy in the clinical lab of chw per routine. bal analysis will consist of western blot staining for the presence of pepsin. demographic data will also be collected from the medical record.

Eligibility criteria:
inclusion criteria: * meet criteria of study population exclusion criteria: * lack of informed consent/assent * pulmonary disease in normal controls

Keywords: pepsin aspiration ge reflux
comparison of different feature engineering methods for automated icd coding

Conditions: Cardiovascular Diseases

Summary: using traditional machine learning classifiers, this study targets on comparing bag-of-words, word2cec and roberta on automated icd coding related to cardiovascular diseases in chinese corpus.

icd coding is quite important as it serves as basis for a wide range of economic and academic applications. currently, manual coding is mainly adopted, which faces several limits like being time-consuming and prone to error, and this makes automated icd coding via machine learning a hot research topic. as an inevitable phase during machine learning, feature engineering plays a crucially important role in leading to promising coding performance. although have reached enlightening conclusions, existing studies lacked comparison of different feature engineering methods. finding out what methods under what circumstances perform better can be quite helpful in promoting practical applications of automated coding. the investigators will implement this study based on inpatient' data collected from electronic medical records from fuwai hospital, the world's largest medical center for cardiovascular disease. bag-of-words, word2cec and roberta will be respectively used to extracted features from training data. then code-wise logistic regression classifiers and support vector machine classifiers will be trained to auto-assign codes. afterwards, performances of the models on test data will be evaluated.

Eligibility criteria:
inclusion criteria: * admissions in fuwai hospital, from january 1, 2019, to february 28, 2019 exclusion criteria: -
effects of walking apnea at low lung volume on hypoalgesia, cardiovascular function and respiratory function

Conditions: Pain; Hypoxia; Hypercapnia; Apnea

Summary: the aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.


Eligibility criteria:
inclusion criteria: - asymptomatic subjects aged between 18 and 64 years. exclusion criteria: * cardiovascular, respiratory, metabolic, neurological or osteomuscular signs or pathologies. * history of epilepsy. * pregnant * pharmacological treatment. * participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 4 weeks.
the application of lens dysfunction index (dli) in the timing of age-related cataract surgery

Conditions: Age-Related Cataract

Summary: before cataract surgery, subjects in the observation group used itrace ocular aberration analyzer（itracey technologies）and iol-master 700 biometer to measure the preoperative dli(dysfunctional lens index) and ss-oct image of the lens, and the researchers used the anterior segment slit lamp to take photos of the anterior segment of the subject's lens in a state of dilated pupils .and self-scoring of the preoperative visual quality assessment scale. healthy subjects in the control group also need to complete the above inspections. after that, three experienced cataract specialist surgeons combined the preoperative optometry data of each subject, the photos of the locs iii anterior segment and the catquest-9sf questionnaire score to determine whether each subjects should undergo cataract surgery. the subjects were divided into cataract surgery group and non-surgical group. finally, statistically study the correlation between the dli index and the degree of lens opacity that has been collected, and use the roc curve to calculate the dli as the best cut-off point of dli to distinguish whether to perform cataract surgery.


Eligibility criteria:
inclusion criteria: * over 40 years old * healthy volunteers with no history of systemic or ocular diseases * patients with simple age-related cataracts without other ocular diseases * those who can communicate with the tester at a normal level * those who can express their own ideas independently exclusion criteria: * irregular corneal astigmatism * corneal opacity * corneal scars * corneal dystrophy * shallow of anterior chamber * retinal abnormalities * history of eye surgery or laser treatment * pupil diameter less than 4.00mm in a dark environment * subjects who did not cooperate well during the examination

Keywords: age-related cataract dli
randomized study of polyethylene-glycol-conjugated interleukin 2 in patients with common variable immunodeficiency

Conditions: Common Variable Immunodeficiency

Summary: objectives: i. determine whether polyethylene-glycol-conjugated interleukin 2 (peg-il-2) can reduce the number of infections in patients with common variable immunodeficiency. ii. determine whether this therapy can improve lung functions in these patients with pulmonary impairment.

protocol outline: this is a randomized, open-label study. patients are randomized to receive polyethylene-glycol-conjugated interleukin 2 (peg-il-2) or placebo. patients receive peg-il-2 or placebo by subcutaneous injection weekly for 18 months. patients maintain a daily diary for 24 months. patients are followed every 4 months for 2 years. completion date provided represents the completion date of the grant per oopd records

Eligibility criteria:
protocol entry criteria: --disease characteristics-- documented common variable immunodeficiency defined as a reduction of serum igg by at least 2 standard deviations in vitro lymphocyte proliferative response to peg-il-2 of at least 10 times more than unstimulated cultures --prior/concurrent therapy-- no biologic response modifier therapy (i.e., interferon, cyclosporin a) except prednisone (maximum 10 mg/day) concurrent treatment with same dosage intravenous gamma-globulin for at least 6 months is required --patient characteristics-- life expectancy: at least 24 months other: not pregnant or nursing hiv negative

Keywords: common variable immunodeficiency immunologic disorders and infectious disorders primary immunodeficiency disease rare disease
efficacy and safety of refeeding in preterm infants with enterostomy

Conditions: Enterostomy

Summary: refeeding is an extracorporeal stool transport from the proximal stoma end to the distal end of stoma. refeeding may be beneficial in preventing malabsorption, electrolyte imbalance, cholestasis and atrophy of the distal intestine. investigators are focused on evaluating the efficacy and safety of the practice of refeeding in preterm infants with enterostomy. clinical data including weight gain, total parenteral nutrition (tpn) usage, and other laboratory findings will be collected. serial citrulline levels during refeeding procedure and pathologic specimens of bowel (at the time of stoma closure) will be collected for evaluating bowel adaptation.


Eligibility criteria:
inclusion criteria: * preterm infants who are less than 35 weeks gestational age at birth and get stomas after laparotomy exclusion criteria: * congenital gastrointestinal malformation * blind pouch (after laparotomy) * refeeding procedure related infection * hemodynamic instability requiring inotropic or vasopressor agents (if the condition improves, the refeeding procedure can be restarted again)
efficacy of prophylactic negative pressure wound therapy (npwt)

Conditions: Wound of Skin

Summary: the role of prophylactic negative pressure wound therapy (npwt) is promising in reducing wound-related complications. however, the prophylactic use of npwt in reducing wound complications in patients who underwent conventional open harvesting of the great saphenous vein has been under-investigated compering with other surgical approaches. therefore, this study aims to assess the effect size of the prophylactic npwt in preventing wound dehiscence in high-risk patients who underwent conventional open harvesting of the great saphenous vein as a conduit for coronary artery bypass.

the study design is a prospective, randomized, controlled, and monocentric trial. the primary endpoint is given by the reduction of wound dehiscence as a dichotomic outcome (yes versus no). more precisely, in the experimental group, we will use the proposed device pico7 (npwt); this device is certificate ce. pico consists of a single-use (i.e., completely disposable) npwt unit, canister, and dressing that are designed for application over clean, closed, sutured, or stapled incisions in a simple peel-and-place process. instead, in the control group, patients will receive standard care. finally, patients eligible to be enrolled in this study will be blindly randomized using for the arm allocation (allocation 1:1). randomization should take place as soon as possible after consent. patients will be randomized on a 1:1 basis to receive either dressing.

Eligibility criteria:
inclusion criteria: * adult patients (aged ≥ 50 years) * diagnosis of diabetes (both type 1 and 2) as comorbidity with anamnesis during the last year of poor glycemic control (hba1c \>7.5%) * bmi ≥ 25 kg/m2 exclusion criteria: * cognitive impairment * anamnesis of non-heling wounds * wagner grade 2-5 foot wound * osteomyelitis * pregnancy * contraindication to use pico7 described previously.

Keywords: negative pressure wound therapy
photodynamic therapy of acne vulgaris - a randomized blinded controlled study

Conditions: Acne Vulgaris

Summary: the purpose of the study is to evaluated the efficacy and tolerability of methyl aminolevulinate and 5-aminolevulinic acid photodynamic therapy in patients with moderate to severe facial acne vulgaris in a randomized controlled and investigator blinded trial.


Eligibility criteria:
inclusion criteria:18 years or older, good health, more than 12 inflammatory facial acne lesions - exclusion criteria:skin type vi, pregnant or lactating woman. oral retinoid use within one year, systemic antibiotics within 1 month, topical acne treatment within 2 weeks. -
effectiveness of titanium niobium nitride coating in total knee arthroplasty

Conditions: Knee Arthritis

Summary: modern knee implants combine several types of metal and therefore potentially expose patients to different metal ions. titanium niobium nitride coating (tinbn) acts like a physical barrier against the corrosion process and the metallic ions release towards the surrounding biologic environment, thus, making tinbn-coated prostheses possible to be safety implanted in metal sensitized patients. the aim of the study is to verify that the postoperative plasma metal concentrations at 1 year are not different than preoperative values.


Eligibility criteria:
inclusion criteria: * patients candidate for unilateral primary total knee arthroplasty exclusion criteria: * existing orthopaedic metal implants * a history of hypersensitivity to metals * preoperative patch-test positivity to co, cr, ni and ti * malignancies * renal insufficiency * severe illnesses that would impair participation in this study
omega-3 fatty acids and chemotherapy-induced neuropathy and inflammation in breast cancer

Conditions: Breast Cancer

Summary: the aim of this study is to assess the effects of n-3 fatty acids on taxane-induced neuropathy and neurotoxic inflammatory agents in patients suffering from invasive breast cancer.

breast cancer is the most common malignancy in women. chemotherapy with taxanes in patients with breast cancer causes some complications and neuropathy is one of the most frequent that is dose limiting and even may cause to stop the therapy. n-3 fatty acids have very significant role in improvement the function of the neurons.n-3 fatty acids decrease the demyelination and toxicities resulting from taxanes. they also lower the level of of the neurotoxic inflammatory agents. so,n-3 fatty acids improve the quality of life in this patients. 52 patients with invasive breast cancer will be randomized in a double-blind placebo-controlled manner to receive either 640 mg oil fish pearls( 54% dha, 10% epa) 3 times a day or placebo( corn oil pearls) for 3 months(during the chemotherapy with taxanes). neuropathy (using emg-ncv test)and the level of il-1,il-6, tnf-alpha, hs-crp and serum level of epa and dha fatty acids will be measured before chemotherapy with taxanes and at the end of the therapy (after 3 months).

Eligibility criteria:
inclusion criteria: * suffering from invasive breast cancer,not receiving any form of supplementations and oil fish exclusion criteria: * suffering from the diseases leading to neuropathy, e.g.diabetes, hyperthyroidism, aids and primary neural diseases * suffering from any other kind of malignancies * receiving any chemotherapeutical agents in the past

Keywords: taxanes breast cancer n3 fatty acids inflammation
the effect of high-intensity laser therapy in patients with carpal tunnel syndrome.

Conditions: Carpal Tunnel Syndrome

Summary: the aim of this study is to evaluate the effects of high intensity laser therapy (hilt) on pain, functional status, hand grip strength and median nerve cross-sectional area in ultrasonography in patients with carpal tunnel syndrome.

patients who are admitted and diagnosed with carpal tunnel syndrome based on anamnesis, physical examination and electromyography are included in the study.

Eligibility criteria:
inclusion criteria: 1. electrophysiologically mild or moderate cts 2. patients who are literate and able to understand verbal instructions in our exclusion criteria: 1. diabetes 2. systemic disorders that may affect treatment such as hypothyroidism, sle, gout 3. history of polyneuropathy, cervical radiculopathy, brachial plexopathy 4. injection for the carpal tunnel in the last 1 month 5. history of severe trauma, fracture, operation to both upper extremities at any time 6. malignancy or history of malignancy 7. renal failure 8. peripheral or central nervous system diseases 9. pregnancy 10. history of physical therapy program for the same hand wrist in the last months.

Keywords: pain high-intensity laser therapy ultrasonography
efficacy of footbaths with ginger powder on subjectively perceived quality of sleep

Conditions: Nonorganic Insomnia

Summary: a randomized, controlled trial to explore whether warm footbaths with added ginger powder can improve the sleep quality of adults with self-perceived insomnia symptoms. participants receive daily footbaths either with warm water alone or with added ginger powder over a period of 2 weeks.

this is a randomized controlled trial with parallel group design to explore the effects of warm water footbaths with added ginger powder (experimental) compared to footbaths with warm water alone (active comparator) on sleep quality in adults with self-perceived insomnia symptoms. participants receive daily footbaths 1-3 hours before bedtime over a period of two weeks. the footbaths are prepared by the participants themselves and carried out at their homes. outcome measures are assessed at baseline (pre intervention) and two weeks after baseline (post intervention). the main focus is on change in subjective quality of sleep as assessed by the pittsburgh sleep quality index (psqi). the statistical analysis comprises analyses of variance based on linear mixed effects models.

Eligibility criteria:
inclusion criteria: * written informed consent * age between 18 and 70 years * self-reported insomnia symptoms exclusion criteria: * known organic insomnia (e.g. periodic leg movements during sleep, restless legs syndrome, sleep apnea syndrome, narcolepsy) * current intake of allopathic hypnotics * shift work * skin lesions at the lower legs or feet * known intolerance or hypersensitivity to ginger preparations * acute mental disorder * varicose vein (degree 3 or 4, classification according to marshall), chronic venous insufficiency * pregnancy * participation in other studies * insufficient knowledge of the german language