Kornimate/medical-research-clean huggingface dataset:
staff absenteeism and delivery of healthcare services during the covid-19 pandemic

Conditions: COVID-19 Pandemic

Summary: work attendance of more than 700 hospital workers was evaluated. the assessment of the number of medical services that were performed was based on monthly reports prepared for the national payer of health services.

a retrospective analysis of above-mentioned data, covering the period january-april 2019 and january-april 2020, was carried out. the evaluation of the staff's absence included all workers employed under an employment contract: 713 workers in 2019 and 747 workers in 2020. the variable number of employees was a result of the employment dynamics in the subsequent 2 years, due to variable quantity of healthcare services that were contracted with the national payer and changes in the form of employment of some hospital workers.three types of analyses were carried out: global analysis, analysis taking into account division into specific professions and the analysis of absence in different hospital organizational units/areas. the absences due to medical reasons, holidays or childcare were analyzed together. the analysis of performing the contracted tasks was shown in relative values ( %). the analysis included the structure of contracted services dividing them into: orthopedics (alloplasty and others), rehabilitation (person-day), rheumatology (drug trials and others). considering the rehabilitation unit, it was subdivided into inpatient and outpatient wards due to temporary closure of the outpatient ward.

Eligibility criteria:
inclusion criteria: all workers employed under an employment contract exclusion criteria: not applicable

Keywords: staff absenteeism healthcare services
impact of adapted aesthetic onco in patients with upper aerodigestive tract cancer during their management

Conditions: Oncology; Aerodigestive Tract Cancer; Suportive Care

Summary: treatment for cancers of the pharyngolarynx is mutilating, with major consequences for patients' lives in terms of physical and functional after-effects. the psycho-social consequences are also significant, notably the metamorphosis of identity linked to the disease and its treatment, which alters the patient's self-image. initial feedback from patients who have been able to benefit from adapted oncoesthetics (oea) is overwhelmingly positive. this study will assess the feasibility of oncoesthetics and describe any obstacles.

the majority of patients treated for vads cancer come from disadvantaged socio-professional and family backgrounds. treatment for cancers of the pharyngolarynx is mutilating, with major consequences for patients' lives in terms of physical and functional after-effects. the psycho-social consequences are also significant, notably the metamorphosis of identity linked to the disease and its treatment, which alters the patient's self-image. the french association for oncological support care (sos) defines socio-aesthetics as "the professional practice of aesthetic care adapted to people who are fragile or suffering as a result of an attack on their physical or psychological integrity, or in social distress". priority patients for aesthetic care are those whose treatments have had an impact on body image (mutilating surgery, skin toxicities), and/or who are in a situation of social precariousness and suffer from a loss of self-esteem. for patients suffering from vads cancer, a population not usually in need of aesthetic care but in need of self-image restoration, an incentive program has been set up. initial feedback from patients who have been able to benefit from adapted oncoesthetics (oea) is overwhelmingly positive. this study will assess the feasibility of oas for vads cancer patients, and describe any obstacles.

Eligibility criteria:
inclusion criteria: * patient aged 18 or over * neoplastic location: oropharynx, oral cavity, hypopharynx, larynx, nasal cavity, salivary glands, cavum, sinus. * patient due to start oncological treatment (recurrence authorized) * patient fluent in french. * affiliation with a social security scheme * signature of informed consent prior to any specific procedure linked to the study * treatment with curative intent exclusion criteria: * breast-feeding or pregnant patient * any associated medical or psychological condition that could compromise the patient's ability to participate in the study * patient deprived of liberty, under guardianship, or subject to a legal protection measure or unable to express their consent. * patient unable to undergo trial follow-up for geographical, social or psychopathological reasons.

Keywords: oncology (organ: upper aero digestive tract) supportive oncology organization of care
peer-led implementation of tb-hiv education and adherence counseling in uganda

Conditions: Tuberculosis; HIV

Summary: this cluster-randomized trial in uganda will evaluate the effectiveness and implementation of a novel, peer-led tb education and counseling strategy to improve outcomes among persons with tuberculosis (tb) with and without hiv/aids and assess the social-behavioral mechanisms underlying the observed treatment effects.

study design aim 1. the investigators will conduct a parallel cluster-randomized hybrid type 2 effectiveness-implementation trial at 16 sites. aim 2. within the aim 1 study, the investigators will nest a longitudinal observational study in both arms of the cluster-randomized trial to determine the feasibility, acceptability, and appropriateness of a peer-navigation strategy for tb-ec. the investigators will concurrently assess biological adherence using urine biomarkers) and will also perform a mediation analysis of social and behavioral factors (i.e., tb knowledge, perceived social support, general self-efficacy, hiv/tb stigma) to identify causal mechanisms of impact. finally, the investigators will pilot and culturally adapt study instruments in a pilot study prior to the trial. aim 3. the investigators will also conduct a qualitative and mixed methods studies to assess the implementation fidelity and context of the peer-navigation strategy for tb-ec: 1. process evaluation of intervention fidelity to quantify the adoption, reach, implementation, and maintenance of the peer navigation strategy, 2. in-depth interviews with people with tuberculosis (pwtb) with and without hiv, 3. in-depth interviews with and direct observation of peer navigators, and 4. focus-group discussions (fgds) with healthcare workers. the focus of this registration is aim 1 and 2.

Eligibility criteria:
inclusion criteria: tb outcomes: * sites will enroll consecutive adults and older adolescents (age ≥18) recorded as new tb cases in the on-site national tb program tb treatment register. art outcomes: * participants must be documented as a people living with hiv (plh) in the tb register. exclusion criteria: tb outcomes: individuals who are * transferring in from off-site * diagnosed with possible or confirmed drug-resistant tb * residing \>40 km from the clinic * lacking mental capacity to participate in peer counseling will be excluded from this study. art outcomes: * the investigators will exclude those with tb meningitis or tb pericarditis for which immediate art is contraindicated; and those with central nervous system tb or tb osteomyelitis because these forms of tb have a different treatment duration.
safety and efficacy of multihance in pediatric patients

Conditions: Central Nervous System Diseases

Summary: the purpose of this study was to assess the safety and enhancing properties of the magnetic resonance imaging (mri) contrast agent multihance in children aged 2 to 17 years having central nervous system (cns) disorders.


Eligibility criteria:
inclusion criteria: * between 2 and 17 years of age * informed consent from parents * assent from patient where required * known or highly suspected disease of the cns and referred for either cranial or spinal mri examination exclusion criteria: * contraindication to mri * undergoing mri in an emergency situation * known allergy to one or more of the ingredients in multihance * sickle cell anemia moderate to severe renal impairment * received another investigational compound within 30 days * pregnancy * lactating females * likely to undergo an invasive procedure within 72 hours of receiving multihance

Keywords: disease of the central nervous system (brain or spine)
a 12-week efficacy study of paracetamol 1000mg sustained-release tablets in patients with osteoarthritis

Conditions: Pain

Summary: the purpose of the study is to determine whether paracetamol 1000 mg sustained-release (sr) tablets administered orally, twice daily are effective and safe in the treatment of patients with osteoarthritis of the knee or hip.


Eligibility criteria:
inclusion criteria: * male or female participants between 40 and 80 years of age * diagnosis of moderate to moderately-severe osteoarthritis (oa) of either the knee or hip with respect to the following: * pain in one knee/hip over 3 months immediately before screening visit * use of non steroidal anti-inflammatory drugs (nsaids), acetaminophen (paracetamol) or any other analgesic for 3 or more days per week for at least 3 months prior to screening visit * clinical diagnosis of osteoarthritis of knee/hip for minimum 6 month duration prior to screening visit * therapeutic benefit with acetaminophen use with a score of ≥ 1 on 5-point categorical scale * radiological evidence of ≥ grade 2 osteoarthritis according to kellgren-lawrence radiographic criteria * increased womac pain subscale score of at least 20 % following untreated run-in period * moderate to moderately-severe self-reported pain on a 5-point categorical scale following untreated run-in period * historical self-reported positive therapeutic benefit with paracetamol use for osteoarthritis pain relief exclusion criteria: * history of surgery or major trauma to the study joint * clinically significant signs or symptoms of inflammation upon completion of run-in period * required ongoing use of analgesic therapy for other indications, anticoagulants, psychotherapeutic agents, aspirin at daily doses greater than 325 mg, statin-class hypolipidemic agents at doses that have not been stabilized, or other treatments know to interfere with pain perception * history of hepatic or renal or liver or biliary disease or gastrointestinal surgery * participants with alanine aminotransferase (alt) \>2 times upper limit normal (2xuln) and bilirubin \> 1.5 times upper limit normal (1.5xuln) (however, if direct bilirubin is \ 1.5xuln is acceptable) * other arthritis type, fibromyalgia or collagen vascular disease or secondary oa of study joint or chronic pain condition
introduction of arpraziquantel treatment for schistosomiasis control in preschool-aged children in endemic areas: a small-scale public health intervention study

Conditions: Schistosomiasis

Summary: the proposed small-scale pilot studies are public health intervention studies implemented through established routine programs and services in the frame of the mass drug administration (mda) campaigns in côte d'ivoire, kenya and uganda. in each country two most promising health intervention platforms were selected for pilot distribution of arpraziquantel 150mg (arpzq). the aim of the small-scale pilot study is to assess the performance of different platforms for distributing arpzq, a child-friendly formulation of praziquantel, to the target population (i.e., preschool-aged children (psac)) currently missed out in schistosomiasis treatment campaigns. the specific objectives of the pilot study are: * to assess the performance of different platforms for delivery of arpzq to psac aged 24 to 59 months in terms of coverage, feasibility and acceptability * to determine social mobilization and training needs for effective delivery of arpzq through different platforms preventive chemotherapy with arpzq will be offered systematically to eligible psac aged 2 to below 5 years of consenting caregivers resident in the study area and reached through the selected platforms. adverse events during mda with arpzq will be documented and reported by using existing tools and established reporting pathways aligned with standard pharmacovigilance and safety guidelines of the national drug authorities. based on routine program processes and forms, variables pertaining to drug logistics, training, drug distribution, passive pharmacovigilance and supervision will be collected in order to measure and generate real-world data related to feasibility, coverage and acceptability of selected platforms and strategies to inform future scale-up to district levels. assessments will take place before (to capture social mobilization and training activities) during and after the drug distribution to document the implementation process and evaluate experiences made by the different stakeholders (e.g. children, parents, community members, health workers, programme staff).


Eligibility criteria:
* living in the designated implementation area since at least 6 months * aged between 24 - 59 months * informed consent available * no acute or chronic illness and/or inability to take oral medication * no reported history of seizures * no known allergic response to praziquantel

Keywords: schistosomiasis preschool-aged children praziquantel arpraziquantel deworming pediatric treatment child health
lumbar thrust-mobilization effects on hip strength and anterior knee pain

Conditions: Anterior Knee Pain Syndrome

Summary: the purpose of this study is to investigate changes in lateral hip muscle strength as well as self-reported pain during the performance of three functional tests in patients with anterior knee pain following a lumbopelvic thrust-mobilization. hypothesis(es): lumbar thrust-mobilization will lead to increased lateral hip strength and decreased anterior knee pain during 3 functional activities (single leg step down, functional squat, drop jump).

the participant will complete a medical history form and undergo a brief physical exam of the lumbar spine and knees to include: lumbar range of motion and mobility testing, knee range of motion, palpation, and knee mobility testing. the participant will complete a hip strength test utilizing the biodex system 4 pro®. the participant will then perform three activities (single leg step down, squat, and drop jump from a 2 foot platform) and provide a self-reported knee pain measure with each activity. a sealed envelope indicating the intervention to be received will be given to the participant. an investigator blinded to the pre and post-measures will open the envelope indicating the intervention to be performed. the participant will be blinded to which intervention group they are categorized to. th e participant will be positioned on a high-low treatment table to receive the assigned intervention. the participant will be positioned to receive either intervention 1 (thrust mobilization) or 2 (sham mobilization). the participant will either receive the thrust-mobilization or sham mobilization up to 2 times on the left and right side. an immediate re-test of hip strength will be conducted followed by performing the same three functional activities (single leg step down, squat, and drop jump from a 2 foot platform) while providing a self-reported pain measure after each activity. follow-up measures at 15 minutes post-intervention and the final measure at 30 minutes post-intervention will be performed.

Eligibility criteria:
inclusion criteria: * healthy males and females between the ages of 18 and 25 with non-traumatic anterior knee pain * able read and write in english * clearly understand the informed consent form exclusion criteria: * low back pain * pregnant or may be pregnant * previously diagnosed with spondylolisthesis, * previously diagnosed with a herniated disc, * signs and symptoms of nerve root compression * history of spine surgery * history of knee surgery * history of cancer * history of compression fracture * history of osteoporosis * history of osteopenia * history of a systemic disease * history of a connective tissue disease * history of a neurological disease * pain with pre-manipulative hold * positive findings on medical history form, or physical exam * presence of anxiety during the procedure
heart math resilience program on jail staff

Conditions: Stress

Summary: the study is a multiple cohort, staggered-entry, waitlist randomized controlled trial evaluating the effectiveness of a comprehensive resiliency-based program in reducing stress for correctional officers employed by the leon county sheriff's office in tallahassee, fl.

the primary objective of the study is to implement and evaluate the effectiveness of a comprehensive resiliency-based intervention, heartmath, designed to reduce stress for correctional officers (cos) currently employed with the leon county sherriff's office in tallahassee, florida. the study will also examine whether the intervention 1) improves perceptions of job satisfaction, workplace safety, and occupational stress; 2) improves co retention and decreases absenteeism; 3) results in less punitive attitudes and greater apprehension to employ use of force.

Eligibility criteria:
inclusion criteria: * leon county sheriff's office jail correctional officers. * attending a defensive tactics training by leon county sheriff's office * age 18 years or older * conversational english * being willing and cognitively able to provide consent. exclusion criteria: * not meeting inclusion criteria

Keywords: chronic stress perceptions of job satisfaction workplace safety occupational stress retention and absenteeism punitive attitudes apprehension to employ use of force heartmath resiliency-based intervention correctional officers
clinical confirmation of a pharmacodynamic interaction between tropisetron and paracetamol

Conditions: Pain

Summary: a previous study has shown that tropisetron inhibits the analgesic effect of paracetamol in healthy volunteers. this study aims at confirming this pharmacodynamic interaction in patients with post-surgery pain.

the study is a comparison of the analgesic action of paracetamol versus tropisetron + paracetamol in 30 patients who had surgery of the ear. the evaluation criteria will be the score on the visual analogue scale for pain evaluation.

Eligibility criteria:
inclusion criteria: * more than 18 years * men or women * ear surgery * written consent given exclusion criteria: * paracetamol hypersensibility * tropisetron hypersensibility

Keywords: pain serotonin interaction patients with postsurgical pain, after ear surgery
bile acid-induced glp-secretion. a study in cholecystectomized subjects

Conditions: Diabetes

Summary: purpose the goal of the present project is to unravel the importance of bile acid-induced glp-1 secretion (via the g protein-coupled receptor tgr5) in human physiology. in the present study the investigators examine the glp-1 secretion in healthy subjects and cholecystectomised patients. thereby the investigators aim to show, that cholecystectomised patients have reduced bileflow after a meal, and as a consequence exhibit a diminished glp-1 response as compared to healthy subjects.


Eligibility criteria:
inclusion criteria: (healthy) * normal fasting plasma glucose * normal glucose tolerance * normal haemoglobin levels * informed content inclusion criteria: (cholecystectomy group) * laparoscopic cholecystectomy \<6 months. indication: gallstones. * normal fasting plasma glucose * normal glucose tolerance * normal haemoglobin levels * informed content exclusion criteria: (both groups) * diabetes * pre diabetes (impaired glucose tolerance or impaired fasting glucose) * 1st degree relatives with diabetes * obesity (bmi \> 30) * inflammatory bowels disease * nephropathy * liver disease * medication which cannot be on hold for 24h
platelet reactivity in septic shock

Conditions: Septic Shock; Thrombocytopenia; Sepsis; Platelet Aggregation; Disseminated Intravascular Coagulation

Summary: coagulation disorders and thrombocytopenia are common in patients with septic shock. despite the clinical relevance of sepsis-induced thrombocytopenia, few studies have focused on the prediction of thrombocytopenia in this setting. the aim of this study was to evaluate whether platelets aggregometry and markers of platelets activation, such as mean platelet volume or platelet volume distribution width, could predict sepsis-induced thrombocytopenia in patients with septic shock and normal platelet count on the day of diagnosis.


Eligibility criteria:
inclusion criteria: * diagnosis of septic shock * platelet count \>150\*103/mcl. exclusion criteria: * age \<18 years * history of any hematologic disorder * chronic liver failure * previous chemotherapy * transfusion of platelet during the previous 4 weeks * renal replacement therapy before icu admission * history of antiplatelet therapy during the 8 days before inclusion * history of heparin-induced thrombocytopenia (hit) or other acquired or induced thrombocytopenia * occurrence of hit (defined as hit score over 3) * active bleeding
detection of minimal change esophagitis by i-scan

Conditions: Gastro-esophageal Reflux Disease; Non-erosive Reflux Disease

Summary: study design and objective the primary outcome of this prospective cohort study was to identify the endoscopic findings that have diagnostic value for the prediction of nerd (minimal change esophagitis) by using hd endoscopy with i-scan. the secondary outcome was to evaluate the response to proton pump inhibitor (ppi) in gerd patients with or without minimal change esophagitis.

background and aims majority of patients with gastro-esophageal reflux disease (gerd) were non-erosive reflux disease (nerd). high definition (hd) endoscopy with i-scan could enhance visualization of mucosal and vascular pattern and might identify changes that were invisible at standard endoscopy. this study aimed to evaluate the endoscopic findings that may have diagnostic value for the prediction of nerd by using hd endoscopy with i-scan. methods patients with typical gerd symptoms and healthy control without gerd symptoms were included and 2 validated gerd questionnaires were completed. the endoscopist was blinded to the presence of reflux symptoms and distal esophagus was examined using standard white light endoscopy followed by i-scan. mucosal morphology at squamocolumnar junction (scj) observed by i-scan were compared between gerd patients and controls.

Eligibility criteria:
inclusion criteria: 18 to 80 years of age and had ability to provide written informed consent exclusion criteria: 1. pregnancy, 2. cirrhosis or presence of gastroesophageal varices, 3. gastrointestinal hemorrhage, 4. angina pectoris, 5. allergy to ppi, 6. high risk or contraindication for endoscopy, 7. chronic cough,laryngitis, asthma.

Keywords: with or without gerd symptoms presenting to gastrointestinal clinic of maharaj nakorn chiangmai hospital november 2009 to november 2010 gerd nerd
outcome after treatment of pulmonary aspergilloma

Conditions: Pulmonary Fungal Diseases

Summary: retrospective analysis of surgery and/or bronchial embolisation for pulmonary aspergilloma.

a retrospective chart analysis, based on the search results from a thoracic surgery database and an interventional radiology database. outcome analysis of all surgically treated patients for a confirmed invasive aspergilloma. comparisson with (preoperative) embolisation of the bronchial circulation.

Eligibility criteria:
inclusion criteria: * histological proven aspergilloma of the lung exclusion criteria: * treatment limited to the use of systemic antifungal agents

Keywords: catheterization, bronchial pneumonectomy lobectomy thoracoplasty