Kornimate/medical-research-clean huggingface dataset:
mri perfusion curves typology and orbital tumors (perform)

Conditions: Orbital Tumor

Summary: orbital masses develop at the expense of the orbital structures lacrimal glands, oculomotor muscles, optic nerve, meningeal spaces, peripheral nerves, bone wall, orbital fat, lymphoid structures or vascular structures. these masses can be tumors, benign or malignant, or pseudotumor, mainly represented by specific or non-specific orbital inflammation. pathology is of considerable importance for the diagnosis and the treatment of those masses. however, biopsy or surgical resection of the orbital masses is sometimes difficult and dangerous outside expert centers. the identification of a non-invasive technique for distinguishing tumors from pseudotumors, thus avoid in some cases a biopsy, would be a major contribution for the patients. for salivary glands, mri allows to identify 4 different types of mri characteristics, one (type c) being related to malignant tumors. in this study, the investigators will try to see if extrapolation of those data to orbiltal tumors is feasible.


Eligibility criteria:
inclusion criteria: * patient aged 18 years or more * with orbital mass for which a biopsy and/or a surgical removal is planned * undergoing an mri * before surgery exclusion criteria: * contra-indication to mri * intolerance to constrast agent * pregnancy * breast feeding * patient under a legal protection procedure * patient denying to participate to the study * lack of affiliation to a social security system

Keywords: mri orbital neoplasm
best incision site for obese patients - low versus high transverse

Conditions: Cesarean Section

Summary: retrospective chart review using both out patient and inpatient records of obese patients (bmi of 30 or greater) who have had a cesarean section since the year 2009. we will evaluate the patient's bmi, their skin incision type at time of c-section, their co-morbidities, number of previous c-sections and post partum follow up for wound infection, wound separation and wound breakdown. we will also review operative notes to evaluate blood loss, length of surgery and complications during surgery. we will obtain maternal characteristics and information about the pregnancy.

past studies have looked primarily at vertical vs low transverse skin incision. there is data that performing a high transverse skin incision on obese patients leads to better visualization and less wound infection but there are few studies comparing it directly to low transverse skin incision. retrospective chart review of obese patient's who have had a cesarean section at st mary's hospital by either a low or high transverse skin incision between january 1, 2009 - july 31, 2014. we will review charts up to 6 week postpartum. pregnancies will be identified through identifing those who have cesarean sections. they will be narrowed down by those who have bmi of \> 30. maternal prenatal records, postnatal records and delivery records will be reviewed.

Eligibility criteria:
inclusion criteria: * obese patients (bmi of 30 or greater) who have had a cesarean section exclusion criteria: * vaginal delivery
preoperative ondansetron lozenge for prevention of postoperative nausea and vomiting in pediatrics undergoing squint surgeries

Conditions: Ondansetron Lozenge; Postoperative Nausea and Vomiting; Pediatrics; Squint

Summary: the aim of this study is to evaluate the role of ondansetron lozenge on prevention of postoperative nausea and vomiting (ponv) in pediatrics undergoing squint surgeries.

post-operative nausea and vomiting (ponv) are two of the most common and distressing complications related to surgery and anesthesia. in several studies ponv occurred in 13% to 42% of pediatric surgical patients, while severe cases are less common, occurring in 1-3% of patients. volatile anesthetics are the main cause in the early post-operative period (0-2 h), with dose-response relationship. in the delayed post-operative period (2-24 h) the main predictors are childhood, ponv in the early period, and the use of postoperative opioids. ondansetron is generally considered to be the first-line antiemetic for patients because of its favorable side effect profile. ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone, ondansetron is an effective drug in the prevention and treatment of ponv by having low side effects.

Eligibility criteria:
inclusion criteria: * age from 4 to 15 years. * american society of anesthesiology (asa) physical status i, ii. * pediatric patients undergoing squint surgeries. exclusion criteria: * patients who had received any medication with antiemetic properties within 24 h before surgery. * post-operative period (for reasons other than rescue antiemetic therapy). * patients with known liver or renal disease. * patients with a history of vomiting or retching within 24 h before surgery.
tcm tongue diagnosis and syndrome differentiation in myasthenia gravis compared to healthy controls

Conditions: Myasthenia Gravis

Summary: myasthenia gravis primarily results from neuromuscular junction dysfunction and damage, leading to chronic muscle weakness. while combined traditional and western medicine treatments are now common, tcm tongue diagnosis remains a simple and practical clinical method. however, results can vary among different practitioners. therefore, you are interested in using scientific methods to compare tcm tongue diagnosis images between patients with myasthenia gravis and healthy individuals to aid in diagnosis.

in taiwan, the prevalence of severe myasthenia gravis is approximately 14 per 100,000 people, with an incidence rate of about 2 per 100,000 people. currently, combined traditional and western medicine treatments are very popular. in traditional chinese medicine (tcm), tongue diagnosis is a simple and practical clinical method, focusing on aspects such as the tongue body, coating, color, and sublingual veins. clinical evaluation often relies on the experience and knowledge of tcm practitioners, which can be influenced by subjective factors like diagnostic skills. as a result, findings may vary depending on the observer. to improve diagnostic accuracy, using scientific methods to support tcm tongue diagnosis can provide more precise information for practitioners and enhance the clinical application value of tongue diagnosis in tcm.

Eligibility criteria:
inclusion criteria: 1. diagnosed with myasthenia gravis by a physician. 2. able to understand and communicate in mandarin and taiwanese. 3. cognitively alert and without a diagnosis of psychiatric disorders. 4. willing to undergo tongue imaging and instrument measurements. exclusion criteria: 1. patients with severe organ diseases. 2. hearing loss patients who are unable to complete the questionnaire. 3. patients with aphasia who are unable to complete the questionnaire. 4. have eaten food or drinks that can easily contaminate tongue coating within 2 hours.

Keywords: myasthenia gravis traditional chinese medicine
carotid arteries stenting complications: transradial approach versus transfemoral

Conditions: Carotid Atherosclerosis; Carotid Stenosis; Ischemic Attack; Stroke; Bleeding

Summary: the aim is to compare the safety of using transfemoral and transradial approach in patient undergoing carotid arteries stenting.

the use of transradial approach in carotid arteries stenting can significantly decrease the amount of adverse events associated with transfemoral approach such as bleeding or hematoma. otherwise providing transradial approach is fraught with technical difficulties of common carotid artery canulation that can result in embolic complications. taking into account the absence of studies in this area of medicine, providing investigation evaluating parameters of safety for both methodics is very actual.

Eligibility criteria:
inclusion criteria: * symptomatic patients with internal carotid artery stenosis(\>50%) * asymptomatic patients with internal carotid artery stenosis(\>60%) * anatomy of internal carotid artery applicable for stent implantation and use of embolic protection device exclusion criteria: * stroke, myocardial infarction or underwent operative treatment within 1 month * prior carotid artery stenting * cerebral vessels aneurisms/ malformations * subclavian artery/ brachiocephalic trunk stenosis * contraindications for antiplatelet or/and anticoagulation therapy

Keywords: carotid atherosclerosis carotid stenosis ischemic attack stroke carotid stenting transradial approach transfemoral approach bleeding thromboembolism embolism neurocognitive disorders
rhodiola rosea in adults with attention deficit/hyperactivity disorder

Conditions: Attention Deficit/Hyperactivity Disorder

Summary: this study evaluates the use of rhodiola rosea in the treatment of attention deficit/hyperactivity disorder (adhd) in adults. half of participants will receive rhodiola rosea, while the other half will receive placebo.

rhodiola rosea is an herbal medicine used for centuries in various medical conditions. many randomized controlled trials have evaluated its usefulness in stress and fatigue. there were benefits in attention in some of these studies. mild side effects and beneficial antioxidant properties make reasonable an assessment of its potential benefits in adults with adhd. to our knowledge, rhodiola rosea was never studied in adhd.

Eligibility criteria:
inclusion criteria: * fulfillment of diagnostic and statistical manual of mental disorders, fifth edition, (dsm-5) diagnostic criteria for adhd in adults * intelligence quotient (iq) above 70 * eligibility to rhodiola rosea exclusion criteria: * clinical contraindication fro rhodiola rosea - * any unstable chronic illness without proper treatment (hypertension, heart, kidney or liver disease) * any significant neurological disease (delirium, dementia, epilepsy, aids, head trauma, multiple sclerosis, stroke, etc) * unstable psychiatric comorbidities requiring immediate treatment (risk of suicide, current substance use disorder, etc.) * pregnant, nursing or absence of reliable contraception * current use of nicotine (\<30 days) * use of anticoagulants * current use of any psychoactive drug (\<30 days) * prior use of stimulants * current or lifetime psychosis- current or lifetime bipolar disorder

Keywords: adhd adults treatment rhodiola rosea
search elevated serum alkaline phosphatase as a marker of prenatal intervillositis chronic histiocytic

Conditions: Chronic Histiocytosis

Summary: background : chronic histiocytic intervillositis is a rare placental disease linked with poor perinatal outcome. in a recent study, a major antenatal increased alkaline phosphatase was suspected in patients affected by chronic histiocytic intervillositis. this increase may correspond to the release of alkaline phosphatase by the syncytiotrophoblaste prejudiced in this pathology. aim : to confirm the association between high levels of alkaline phosphatase and the occurrence of chronic histiocytic intervillositis.

single-center study of case-control comparing three groups of patients matched for gestational age at the time of sampling. the case group will be composed of patients who experienced chronic histiocytic intervillositis which an alkaline phosphatase assay is available during pregnancy (retrospective recruitment). two control groups will be prospectively: the first will include patients whose pregnancy is low risk. the second will consist of pathological pregnancies (iugr, preeclampsia and death in utero). all patients will have a blood sample with determination of serum alkaline phosphatase activity and examination of the placenta at delivery.

Eligibility criteria:
inclusion criteria: * patient aged 18 years or more * having signed a free and informed consent * enjoying a social security scheme inclusion criteria for cases: * patient who gave birth at the lille university hospital between 2000 and 2009. * lesion of intervillositis chronic histiocytic (ihc) diagnosed during histological examination of the placenta. * an alkaline phosphatase assay during pregnancy is available and has been achieved at university hospital of lille. * prior information and not opposition of the patient to the secondary use of data collected in medical file. inclusion criteria for low-risk pregnancy : * no pathological obstetric history, no current pregnancy complications * followed antenatal clinics at the lille university hospital * a gestational age corresponding to one of the cases (pairing ± 1 week) * no chronic intervillositis after pathological examination of the placenta inclusion criteria for high-risk pregnancy: * patient hospitalized in the maternal-fetal pathology of the lille university hospital service * presence of iugr, death in utero or severe preeclampsia with fetal repercussion * a gestational age corresponding to one of the cases (pairing ± 1 week) * no chronic intervillositis after pathological examination of the placenta exclusion criteria: * twin pregnancy * liver disease in the interrogation * lack of consent of the patient * patient not covered by a social security scheme * patient minor * patient under guardianship

Keywords: chronic histiocytic intervillositis serum alkaline phosphatase placenta case-control study
lyt-100 in patients with idiopathic pulmonary fibrosis (ipf)

Conditions: Idiopathic Pulmonary Fibrosis

Summary: this study a randomized, double-blind, four arm study to evaluate the safety and efficacy of lyt-100 compared to pirfenidone or placebo in adults with idiopathic pulmonary fibrosis.

this study is a randomized, double-blind, being conducted at centers globally to evaluate the safety and efficacy of lyt-100 compared to pirfenidone or placebo in 240 treatment naïve adult patients with ipf ≥ 40 years in age. patients will be randomized in a ratio of 1:1:1:1 to receive treatment of lyt-100, pirfenidone, or placebo to be taken daily for up to 183 days (26 week treatment period) with the primary outcome of rate of decline in forced vital capacity (fvc; in ml) over 26 weeks. secondary endpoints, including spirometry, inflammatory biomarkers, and patient-reported outcomes will also be evaluated. after completion of the double-blind period of the study, patients may participate in a long-term extension to evaluate tolerability and long-term safety. patients receiving lyt-100 in the double-blind period will continue the dose throughout the long-term extension. patients receiving pirfenidone or placebo in the double-blind period will be re-randomized in a 1:1 ratio to receive lyt-100 550mg or 825mg tid dose throughout the long-term extension.

Eligibility criteria:
key inclusion criteria: * treatment naïve patients or those with \<6 months of exposure to nintedanib with physician diagnosed ipf based on ats/ers/jrs/alat 2018 guidelines * idiopathic pulmonary fibrosis on hrct, performed within 12 months of visit 1 as confirmed by central readers * dlco corrected for hemoglobin (hb) \[visit 1\] ≥ 30% and ≤90% of predicted of normal * fvc ≥ 45% of predicted normal key exclusion criteria: * primary obstructive airway physiology (pre-bronchodilator fev1/fvc \< 0.7 at visit 1) * known explanation for interstitial lung disease, including but not limited to radiation, sarcoidosis, hypersensitivity pneumonitis, bronchiolitis obliterans organizing pneumonia, human immunodeficiency virus (hiv), viral hepatitis, and cancer * diagnosis of any connective tissue disease, including but not limited to scleroderma/systemic sclerosis, polymyositis/dermatomyositis, systemic lupus erythematosus, and rheumatoid arthritis * major extrapulmonary physiological restriction (e.g., chest wall abnormality, large pleural effusion) * cardiovascular diseases, any of the following: * uncontrolled hypertension, within 3 months of visit 1 * myocardial infarction within 6 months of visit 1 * unstable cardiac angina within 6 months of visit 1 * prior hospitalization for confirmed covid-19, acute exacerbation of ipf or any lower respiratory tract infection within 3-months of visit 1

Keywords: ipf lung fibrosis respiratory disease
atlantic canada modified constraint induced movement therapy trial

Conditions: Stroke

Summary: the purpose of this study is to examine the effectiveness and feasibility of a modified constraint induced movement therapy (mcimt) intervention on upper limb function in two groups of patients acutely post-stroke; 1) an experimental group that will participate in a 10 week mcimt intervention designed to improve upper limb function, in addition to usual care, and 2) a control group that will participate in a program of usual care consisting of a rehabilitation intervention for the affected upper limb that is dose-matched to the experimental group.


Eligibility criteria:
inclusion criteria: 1. first symptomatic stroke (either ischemic or hemorrhagic) resulting in upper limb hemiparesis 2. the ability to perform a two-step command 3. age ≥ 18 years 4. residence within a 75 km radius of the queen elizabeth ii health sciences centre 5. with regard to the affected upper limb, subjects will meet standard criteria for modified constraint induced movement therapy (mcimt) including at least 10 degrees of active wrist extension, at least 10 degrees of thumb abduction/extension, and at least 10 degrees of extension in two additional digits, repeated three times in one minute exclusion criteria: 1. have excessive pain in the affected upper limb (defined as \> 4 on a 10 centimeter visual analog scale) 2. presence of dementia or aphasia as defined by a score of \< 26 on the montreal cognitive assessment 3. have a diagnosis of pre-stroke dementia 4. have a terminal illness, life-threatening co-morbidity or concomitant neurological or psychiatric illness 5. excessive tone in the upper limb (\> 3 on the modified ashworth scale) 6. motor activity log score \> 2.5 (amount of use sub-scale)

Keywords: stroke extremity, upper
biofreeze® vs. a placebo on chronic low back pain walking gait characteristics and pain

Conditions: Chronic Low Back Pain

Summary: the purpose of this study is to determine the effect of biofreeze® versus a placebo on walking gait characteristics and pain during walking in individuals with clbp.

a convenience sample of 20 participants, 18 years or older with clbp will be recruited for this study. participants must have clbp and be able to perform all study procedures. all interested participants will report in comfortable clothing and sneakers. after explanation of the study and consent, participants will complete the demographics questionnaire, nih clbp minimal dataset, 10-point numeric pain rating scale (nprs), and the roland-morris low back pain and disability questionnaire (rmdq). participants will then complete a 3-minute walking baseline assessment. following the assessment, participants will rate their pain and be randomly assigned receive a blinded topical of either biofreeze® or a placebo. both the participant and the investigator will be blind to assigned products. the dose of both gels will be 5 ml per side of the low back. the participant will wait 15 minutes, rate their pain, and repeat the 3-minute walking assessment and rate their pain again. next, there will be a minimum of a 24-72-hour washout period at which time the participants will return and repeat the same protocol using the other topical.

Eligibility criteria:
inclusion criteria: * must have clbp and be able to perform all study procedures. clbp will be defined as pain, muscle tension, or stiffness localized between the lower posterior margin of the rib cage and the horizontal gluteal fold lasting at least 12 weeks and has resulted in pain on at least half the days in the past 6 months exclusion criteria: * pregnancy, cancer, spinal or hip surgery, or a corticosteroid injection within the past 4 weeks
cognitive effects of omega-3 supplements in children with mild to moderate malnutrition

Conditions: Malnourishment

Summary: adequate nutrition is one of the critical biological processes to learning and cognitive development of children. and is understandable that malnourishment affect these processes. moreover, in recent decades it has been investigated the beneficial effects of omega-3 in cognitive development and academic performance. however, studies have been limited. therefore is of interest to know the effects that has supplement with omega-3 for children 8-12 years with malnutrition in a randomized, blind, placebo-controlled.

adequate nutrition is one of the most critical biological processes to learning and cognitive development of children, and malnourishment is understandable these processes are affected. moreover, in recent decades is has been investigated the beneficial effects of omega-3 in cognitive development and academic performance. however, studies have been limited. the present study will investigate the efficacy of omega-3 fatty acids supplement on cognition and academic performance in children attending elementary school. the study will follow a randomized, double-blind, placebo-controlled design in which children aged 6-12 years will followed for a period of three months to assess cognitive development, academic performance and nutritional status . intervention will take place in elementary schools, where children will receive two intervention products daily and one more in their houses. the products will contain omega-3 fatty acids, placebo, or only neuropsychological evaluation (control group with normal nutrition children). at baseline, and 3months cognitive tests will be administered and assess nutritional status. compliance will be measured weekly. we hypothesize that after 12 months of intervention, children consuming omega-3 fatty acids will have statistically significant higher improvement in scores on cognitive tests, than placebo and normal nutrition children.

Eligibility criteria:
inclusion criteria: 1. children aged 8- 12 years that attending the selected elementary schools. 2. whit no problems for swallowing pills. 3. willing to participate in the study and perform all measurements including anthropometry and cognitive evaluation 4. informed consent signed by parent or caregiver. 5. parents intend to stay in the study for three months. exclusion criteria: 1. neurological and/or hormonal illnesses. 2. children using medication which interferes with study measurements. 3. omega-3 or any other vitamin supplements consumption within the last 6 months.

Keywords: omega-3 cognition malnourishment
an observational study to evaluate azd9291 treatment in patients with t790m positive non-small cell lung cancer

Conditions: Non Small Cell Lung Cancer

Summary: azd9291 early access program (eap) was available in taiwan during october 2015 to september 2016, a time period before the approval of azd9291, to supply the unlicensed azd9291 for the nsclc patients who received at least one prior egfr tki therapy. at the end of september 2016, more than 450 patients have been under azd9291 treatment through the eap. this observational study aims to evaluate the clinical benefit of azd9291 treatment for these patients who were in the eap

azd9291 early access program (eap) was available in taiwan during october 2015 to september 2016, a time period before the approval of azd9291, to supply the unlicensed azd9291 for the nsclc patients who received at least one prior egfr tki therapy. at the end of september 2016, more than 450 patients have been under azd9291 treatment through the eap. this observational study aims to evaluate the clinical benefit of azd9291 treatment for these patients who were in the eap

Eligibility criteria:
inclusion criteria: * at least 20 years of age * patients who were in the azd9291 early access program * received at least one dose of azd9291 treatment as mono-therapy, supported by available source documents * patient who discontinued the single use of azd9291, had disease progression, or died under azd9291 treatment, whichever comes last, during the period from october 01, 2015 to december 31, 2018 * patients agree to provide the written informed consent or the informed consent is waived by irb. exclusion criteria: • patients who did not receive at least one dose of egfr tki for the treatment of egfr mutation (+) nsclc