Kornimate/medical-research-clean huggingface dataset:
effects of pnf patterns training on trunk balance, and gait in chronic stroke patients

Conditions: Stroke, Ischemic

Summary: to determine the effects of pnf patterns training on trunk balance and gait in chronic stroke patients.

this study will be conducted to investigate the effects of pnf patterns training on the trunk control, balance, and gait ability of chronic stroke patients. data will be collected from stroke patients from government mian munshi hospital (dhq) and riphah rehabilitation center. a consecutive sampling technique will be use which is based on 6 months' time period. tis (trunk impairment scale), bbs (berg balance scale), 10 mwt (meter walk test) will be used as a tool to collect the data. spss 21 version will be used for data entry and analysis. this study will provide the effects of pnf patterns training on the trunk control, balance, and gait ability in chronic stroke patients. all possible patients will be taken using random sampling. single plane training and diagonal pattern training will use. the subjects will randomly assign to the experiment group (diagonal pattern training) and the control group (single plane training). diagonal pattern training will modified with proprioceptive neuromuscular facilitation technique's chopping and lifting pattern to create 10 movements. informed consent will be taken from all patients.

Eligibility criteria:
inclusion criteria: * chronic stroke patients whose onset of stroke was at least 6 months to two years * ability to maintain an independent standing posture for 30s, ability to walk 30m alone indoor. * patient with the ability to communicate enough and to understand oral instructions given by the therapist. * patients who were not using assistive devices * patients receiving drug therapy of internal medicine for the alleviation of spasticity. exclusion criteria: * unconscious patients. * patients undergone spine surgery. * patients with hemi neglect. * sensory ataxia or cerebellar ataxia. * coronary heart disease (chd) or peripheral arterial disease (pad). * cardio respiratory problems.

Keywords: stroke gait disorder balance; disorder,
long term results in hypoplastic aortic arch repair in neonates using a glutaraldehyde treated autologous pericardial patch

Conditions: Congenital Hypoplasia of Aortic Arch

Summary: hypoplastic aortic arch is a congenital heart defect that is prejudicial for the growth of newborns. it is often associated to other heart defects. different surgical techniques exist to address this defect, but the literature is very poor with regards to the use of an autologous pericardial patch. most use extensive dissection techniques or synthetic patches. here investigators report institution's original approach using the newborns own pericardium for what investigators believe to be an optimal correction of the hypoplasia., with preserved growth potential.

retrospective analysis of an already well codified surgical intervention carried out in huderf under extra-corporeal circulation

Eligibility criteria:
inclusion criteria: * newborns with a hypoplastic aortic arch undergoing a first intervention exclusion criteria: * none

Keywords: aortic arch hypoplasia glutaraldehyde treated autologous pericardium single stage repair congenital heart defects newborns
community implementation of keep: fidelity and generalization of parenting

Conditions: Behavior Problems

Summary: the primary goal of this study is to examine the fidelity and generalization of parenting effects of the keep foster parent training intervention as it is being delivered within a child welfare system of care by a community mental health provider.

the primary goal of this study is to utilize this opportunity as a real-world platform for addressing three key questions that need to be answered prior to wide-scale implementation of the keep intervention. first, do the effects of the keep parent training generalize (concurrently) to other children currently in foster and kin intervention homes and lead to reductions in overall levels of behavior problems? second, does the keep intervention continue to have effects after the completion of the intervention and generalize (temporally) to new children who enter the homes of these families at a later point in time? finally, as the keep intervention is being implemented by a community agency in a real-world system of care, can the intervention be delivered and maintained in a manner that preserves the goals and quality of the intervention? children in foster care, between the ages of 5 and 12, will be randomly assigned to one of two conditions - the keep intervention or a "services as usual" condition. in the keep intervention condition, foster and kin caregivers will participate in 16 weekly group meetings. outcomes to be assessed include child problem behavior (of the focal child and other children in the household), child functioning, parental stress, family functioning, use of mental health services, child placement changes (e.g., reunification with biological parents, move to another foster home), and foster parent retention rates. in addition, for a year following the completion of the intervention, new children entering the home of foster/kin caregiver will be included in the assessments, along with the impact of these additional children on parental stress and family functioning. finally, several dimensions of intervention fidelity (e.g., facilitator adherence and group engagement) will be assessed and examined in relation to child, family, and system outcomes.

Eligibility criteria:
inclusion criteria: * any child between ages 5 and 12 in relative or non-relative foster care exclusion criteria: * only medically fragile children

Keywords: behavior problems parent training foster care
evaluate the efficacy and safety of vvz-149 injections for the treatment of postoperative pain following bunionectomy

Conditions: Pain, Postoperative

Summary: the purpose of this phase 2 study is to evaluate the efficacy and safety of an analgesic drug candidate, vvz-149 injections for treating post-operative pain following bunionectomy.


Eligibility criteria:
inclusion criteria: * men and women must be between the ages of 18 to 70 years, inclusive. female subjects must meet additional criteria in relation to childbearing potential. * subjects must be undergoing a planned bunionectomy without collateral procedures. * subjects must have the ability to provide written informed consent. * subjects must have the ability to understand study procedures and communicate clearly with the investigator and staff. * subjects must be classified as american society of anesthesiologists risk class i to ii. exclusion criteria: * subjects undergoing emergency or unplanned surgery. * subjects undergoing a repeat operation. * subjects with pre-existing conditions (other than bunion) causing preoperative pain at the site of surgery. * female subjects who are pregnant or breastfeeding. * diagnosis of chronic pain and ongoing or frequent use of pain medications.
self-gated breath-hold technique for helical tomotherapy in patients with non-small cell lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: non-small cell lung cancer (nsclc) is a disease that often cannot be surgically operated on. as a result, treating the tumor with radiation has become the main standard of treatment. radiation therapy though, is limited by various factors, including the difficulty in properly imaging the lung tumor since the lung can move up to 4 cm between breathing in and out. consequently, a radiation oncologist must consider a larger area of the lung to treat with radiation - increasing the amount of normal tissue exposed to harmful rays and therefore leading to increased side-effects. two techniques being explored into improving tumor management while minimizing the side effects in nsclc are breath-held gating and tomotherapy. breath-held gating is a technique for consistently imaging the tumor at the right moment in a patient's breathing cycle - decreasing the normal tissue exposed to harmful radiation. tomotherapy, a new technique in delivering radiation, will further allow the investigators to focus treatment on the tumor and exclude more normal tissues. therefore, they hope that these methods will prove to be a better way in treating people with nsclc.

non-small cell lung cancer (nsclc) is a disease that often presents as an unresectable tumor. as a result, radiotherapy is the main standard of treatment. unfortunately, radiotherapy is limited by several factors, including that the lung can move up to 4 cm between inspiration and expiration. as a result, a radiation oncologist often has to widen his treatment field to include for this motion. this leads to greater side effects for the patient. two techniques that are being explored to improve the tumor control of radiotherapy and to minimize side effects to normal tissues in nsclc treatment include breath-held gating and tomotherapy. breath-held gating will allow the investigators to treat patients at the right moment in their breathing cycle consistently - minimizing the normal tissue exposed to radiation. in addition, both gated breathing and tomotherapy will allow the investigators to create a more refined tumor volume treated and exclude more of the normal tissues. consequently, they hope these methods will prove to be a better way to treat patients with non-resectable nsclc.

Eligibility criteria:
inclusion criteria: * stage i-iii nsclc * karnofsky performance status (kps) equal to or greater than 70 * forced expiratory volume in 1 second (fev1) equal to or greater than 1.0l exclusion criteria: * myocardial infarction (mi) disease * recurrent disease * complete tumour resection

Keywords: radiation therapy carcinoma non-small cell lung
predictability of the ability to perform an emergency stop after surgery for inguinal hernia

Conditions: Inguinal Hernia

Summary: several studies exist on patient performance in drive simulators especially around and after surgery. recommendations concerning the ability to drive after inguinal hernia are scarce and so far do not offer conclusive results. aim of the study is to analyse reaction time and foot transfer time (together brake response time) and brake force in a brake simulator before and after scheduled inguinal hernia surgery (liechtenstein procedure).


Eligibility criteria:
inclusion criteria: * scheduled surgery for inguinal hernia of the right groin with lichtenstein procedure * valid driving license * male and female exclusion criteria: * lacking driving license * pregnancy * neuromuscular disorder (e.g. myopathy, muscular dystrophy) * central neurological disorders/diseases (e.g. apoplexia, psychiatric diseases)
tübinger diabetes mellitus database (tuedid)

Conditions: Diabetes Mellitus

Summary: diabetes mellitus is a widespread disease with increasing prevalence worldwide. patients with diabetes can develop multiple late complications such as neuropathy, retinopathy, nephropathy and cardiovascular comorbidities. so far, there are no reliable predictive tools or markers to estimate if, when and to what extent a patient with diabetes develops late complications. for the patients quality of life and for health economic reasons an improved risk assessment would be desirable. the prospective tuedid study will characterize diabetic patients to look out for parameters the predict progression of diabetes and its complications.


Eligibility criteria:
inclusion criteria: * \>18 years exclusion criteria: * no written informed consent
effect of exercise and/or liraglutide on vascular dysfunction and insulin sensitivity in type 2 diabetes ( zql007)

Conditions: Type2 Diabetes

Summary: the primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular function in the larger conduit vessels, and enhances insulin's metabolic action in humans with type 2 diabetes. subjects will be randomized to one of the three groups: exercise training, liraglutide treatment, and exercise + liraglutide. they will be studied at the baseline and then after 16 weeks of intervention.

our hypothesis is that sustained activation of the glp-1 receptor with liraglutide or exercise training will enhance microvascular perfusion, promote angiogenesis, and improve microvascular response to insulin in muscle, leading to increased muscle delivery of oxygen and nutrients and increased exercise tolerance in subjects with type 2 diabetes.

Eligibility criteria:
inclusion criteria: * age 21-60 * a1c ≤ 8.5% * never on glp-1ra (eg: exenatide, liraglutide) or dpp4i ( eg: sitaglipton) * on stable dose of oral hypoglycemic agents \>4 months * on stable dose of other medications for \>4 months exclusion criteria: * taking insulin * smoking presently or in the past 6 months * bp \>160/90 * bmi \>35 * family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome * history of congestive heart failure, ischemic heart disease, severe pulmonary disease, liver or kidney disease. * any vascular disease such as myocardial infarction, stroke, peripheral vascular disease * presence of an intracardiac or intrapulmonary shunt (we will screen for this by auscultation during the physical exam by pi). * pregnant or breastfeeding. * known hypersensitivity to perflutren (contained in definity)
clinical performance of all-ceramic posterior crowns. a randomized, prospective clinical.

Conditions: Dental Prosthesis Failure

Summary: this is a randomized, prospective clinical trial. the aim of the project is to assess the clinical performance of three types of tooth-supported crowns; monolithic high translucent colored zirconia, crowns of high-translucent colored zirconia with a mini-veneer buccally and crowns of lithium-disilicate glass-ceramic. crowns will be placed on posterior teeth and evaluated from an esthetic and functional point of view, to identify if there are any differences between the materials.

90 monolithic tooth-supported crowns are planned to be included in the study; 30 crowns of high translucent zirconia (bruxzir, glidewell), 30 crowns of high translucent zirconia (bruxzir, glidewell) with a mini-veneer of porcelain and 30 crowns of lithium-disilicate glass-ceramic (ips e.max cad, ivoclar vivadent ag, schaan, liechtenstein). patients with indications for single crowns will be recruited from three general dental clinics. inclusion criteria for participating in this study are patients in need of crowns in the posterior dentition, premolars and molars. exclusion criteria are patients with high caries activity/risk for caries and/or advanced periodontal disease. patients who meet the criteria will be offered the opportunity to participate in the study. they will receive written information about the study design, clinical procedures and the materials and methods to be used. patients who are interested will confirm their participation by a written consent. the patients will be offered an extended warranty for the crowns in case of failure. the study has been approved by the regional ethical board in lund, sweden

Eligibility criteria:
inclusion criteria: * need of one or more dental crowns in the posterior dentition, premolars and molars exclusion criteria: * high caries activity/risk for caries and/or advanced periodontal disease

Keywords: all ceramic zirconia crown clinal trial
application of unilateral epidural anesthesia in older patients with hip fracture

Conditions: Spinal Anesthesia

Summary: because of population ageing, fragility fractures have become a huge burden on healthcare systems and wider society. fractures result in a sharp drop in both short-term and long-term quality of life, they have a strong influence on activities of daily living and mobility, and they are associated with a significant increase in 1-year mortality (18%-36%). surgery can benefit elderly patients with hip fractures to an extent, but it entails inevitable risks, particularly with respect to general anesthesia. in recent years unilateral spinal anesthesia has attracted attention due to the advantages of hemodynamic stability, reduced anesthetic dosage, and sufficient sensory block. on the basis of a previous study, in the current study anesthetics were directly implanted into the unilateral epidural space in elderly patients with hip fractures prior to the completion of surgery. data from 106 patients with old hip fractures who had undergone surgical treatment incorporating unilateral epidural anesthesia (uea) or combined lumbar and epidural anesthesia were retrospectively analyzed in an attempt to provide a feasible solution for this kind of patients' anesthesia.

surgery can benefit elderly patients with hip fractures to an extent, but it entails inevitable risks, particularly with respect to general anesthesia. in recent years unilateral spinal anesthesia has attracted attention due to the advantages of hemodynamic stability, reduced anesthetic dosage, and sufficient sensory block. on the basis of a previous study, in the current study anesthetics were directly implanted into the unilateral epidural space in elderly patients with hip fractures prior to the completion of surgery.

Eligibility criteria:
inclusion criteria: had a fracture of a proximal femur were aged \> 65 years the fracture occurred within 2 weeks of receiving treatment with comorbidities including pulmonary disease, arrhythmia, senile valve disease or lacunar infarction underwent intraspinal anesthesia during surgery exclusion criteria: had a secondary fracture after endoprosthetic reconstruction or intramedullary nail had a pathological fracture caused by tumor or tuberculosis condition was accompanied by lower limb nerve dysfunction had a cognitive or psychiatric disorder coagulation disorders hospitalization data were incomplete.

Keywords: unilateral epidural anesthesia combined lumbar and epidural anesthesia
a phase 1/2, open-label, safety and dosing study of autologous cart cells (desmoglein 3 chimeric autoantibody receptor t cells [dsg3-caart] or cd19-specific chimeric antigen receptor t cells [caba-201]) in subjects with active, pemphigus vulgaris (reset-pv)

Conditions: Pemphigus Vulgaris

Summary: a phase 1/2, open-label, safety and dosing study of autologous cart cells (desmoglein 3 chimeric autoantibody receptor t cells \[dsg3-caart\] or cd19-specific chimeric antigen receptor t cells \[caba-201\]) in subjects with active, pemphigus vulgaris

pemphigus vulgaris (pv) is a b-cell mediated autoimmune disorder in which painful blisters are formed on the skin or mucosal membrane, including the mouth, nose, throat, eyelids, anus, and genitals. this phase 1/2 study is being conducted to find the maximum tolerated dose and optimal fractionated infusion schedule of an investigational cell therapy, dsg3-caart, that can be given to patients with mucosal pv who are inadequately managed by standard therapies. a sub-study will be conducted to investigate if caba-201 can be safely administered while achieving clinical responses without the need for preconditioning in pv patients. dsg3-caart or caba-201 may potentially lead to complete and durable remission of disease.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of mpv by prior or screening biopsy and prior positive anti- dsg3 antibody elisa * mpv inadequately managed by at least one standard immunosuppressive therapies * active mpv at screening * anti-dsg3 antibody elisa positive at screening inclusion criteria for caba-201 sub-study * confirmed diagnosis of pv by prior or screening biopsy and prior positive dsg3 elisa, iif, and/or dif * pv inadequately managed by at least one standard immunosuppressive therapy * active pv at screening * dsg3 elisa positive at screening exclusion criteria: * active cutaneous lesions associated with pv that indicates mucocutaneous rather than mucosal-dominant disease * rituximab in last 12 months unless pv symptoms have recently worsened or anti-dsg3 antibody titers have recently increased * prednisone \> 0.25mg/kg/day * other autoimmune disorder requiring immunosuppressive therapies * investigational treatment in last 3 months exclusion criteria for caba-201 sub-study * have paraneoplastic pemphigus or active malignancy (not including non-melanoma skin cancer) * have received rituximab or other anti-cd20 or anti-cd19 therapies in last 12 months unless anti-dsg3 antibody titers have recently increased or pv symptoms have recently worsened * prednisone \> 0.25mg/kg/day * other autoimmune disorder requiring immunosuppressive therapies * investigational treatment in last 3 months

Keywords: pemphigus pemphigus vulgaris caar-t therapy car-t therapy desmoglein 3 cell therapy autoimmune disease autoimmunity skin diseases, vesiculobullous immunotherapy, adoptive immune system diseases caba-201 anti-cd19 car-t therapy
optic nerve head strain as biomarker for glaucoma

Conditions: Glaucoma, Open-Angle

Summary: the investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.

existing glaucoma patients and suitable control adults will be imaged with an fda-approved optical coherence tomography instrument. those who are imaged at 2 different eye pressures will generate biomechanical strain estimates. these will be compared to visual field and retinal nerve fiber layer measurements over time. the investigators expect that baseline strain and their changes over time will be associated with progression rate of glaucoma damage, providing a biomarker for susceptibility.

Eligibility criteria:
inclusion criteria: * existing glaucoma patients of johns hopkins exclusion criteria: * inability to perform imaging * illiterate * hearing impaired * non-english speakers
efficacy and safety of oral bg00012 in relapsing-remitting multiple sclerosis

Conditions: Relapsing-Remitting Multiple Sclerosis

Summary: to determine if treatment with bg00012 can decrease the number of ms relapses during a certain time period. to determine if, over time, bg00012 treatment can decrease the number of certain types of brain lesions commonly seen in ms patients and slow down the time it takes for the disease to get worse. the purpose of this study is also to determine the safety of bg00012 and how well it is tolerated. another goal is to see what effect bg00012 may have on tests and evaluations used to assess ms.


Eligibility criteria:
key inclusion criteria: * unless otherwise specified, to be eligible to participate in this study, candidates must meet the following eligibility criteria at the time of the randomization: * must have a confirmed diagnosis of rrms according to mcdonald criteria #1-4. * must have a baseline edss between 0.0 and 5.0, inclusive. * must have relapsing-remitting disease course. key exclusion criteria: * unless otherwise specified, candidates will be excluded from study entry if any of the following exclusion criteria exist at randomization: * other chronic disease of the immune system, malignancies, acute urologic, pulmonary, gastrointestinal disease. * pregnant or nursing women. note: other protocol-defined inclusion/exclusion criteria may apply.

Keywords: relapsing oral remitting multiple sclerosis