Kornimate/medical-research-clean huggingface dataset:
digital health literacy intervention for disadvantaged women during corona

Conditions: Health Literacy

Summary: the aim is to deliver a digital health literacy intervention to disadvantaged women to improve their health behaviors with regard to (i) hygiene and sanitation, and (ii) coronavirus awareness and prevention in four provinces of pakistan through women community health workers.

there is a need to continue primary healthcare services through digital communication for disadvantaged women living in underdeveloped areas of pakistan, especially in the age of coronavirus pandemic, social distancing, and lockdown of communities. this project will be the first of its kind in aiming to provide women with a smartphone and digital access for a digital health literacy intervention through community healthcare workers. the majority of poor women in pakistan who are dependent on primary health services: 1. suffer from health challenges more than men due to multiple social and structural disadvantages, 2. are the dominant care-providers and nurturers in the home, and 3. need support in understanding public health messages during health crises due to low health literacy and awareness. the digital health literacy intervention will be delivered in target two areas: (i) hygiene and sanitation, and (ii) coronavirus awareness and prevention. women will be sampled from disadvantaged areas across the four provinces of pakistan- baluchistan, kpk, punjab, and sindh. a target of 1,000 women will comprise the sample with 500 women each assigned to the control and experiment group.

Eligibility criteria:
inclusion criteria: * disadvantaged women dependent on primary healthcare services * women of the reproductive age group, 15 years to 49 years exclusion criteria: * women above 49 years

Keywords: digital health literacy community healthcare workers coronavirus primary healthcare maternal and child health
effect of islet autotransplantation compared to oral antidiabetic drug.

Conditions: Partial Pancreatectomy Due to Benign Pancreatic Neoplasm

Summary: * effects of autologous islet transplantation were compared to those of oral anti-diabetic drugs after distal pancreatectomy. * the primary interest is a insulin-secretory function after the surgery in two intervention groups.


Eligibility criteria:
inclusion criteria: * patients who underwent distal pancreatectomy for pathologic diagnosis of pancreatic mass exclusion criteria: * prior history of diabetes mellitus * patients whose fasting, post-load (75g ogtt) glucose or hba1c level meet ada diagnostic criteria * patients who refused to participate the study

Keywords: autologous islet transplantation partial pancreatectomy pancreatogenic diabetes
study of febuxostat effect on blood pressure in patients with high normal blood pressure

Conditions: Prehypertension; Gout; Pulse Wave Velocity; Hypertension; 24 Hour Blood Pressure

Summary: high normal blood pressure, also called prehypertension, is a significant problem. high uric acid in the blood, the same thing that causes gout, may cause higher blood pressures. the investigators plan to monitor the effects of the drug febuxostat(trade name uloric) on blood pressure and stiffness of the main blood vessels and see if lowering uric acid has any effect.


Eligibility criteria:
inclusion criteria: * prehypertensive male and female subjects with sbp =120-140 mmhg or dbp =80-90 mmhg (as determined by seated office bp). * plasma uric acid level ≥5 mg/dl * ages 18-50 * non-smokers * subjects will need to remain in the san diego area for the duration of the study and be accessible by telephone or email. exclusion criteria: * no current smoking in the prior 6 months. * any history of any serious medical conditions requiring close monitoring from physicians- such as liver impairment, chronic kidney disease, or diabetes mellitus. participants not currently under the care of a physician for these conditions will be eligible for the study. * any history of gout, hypertension, hypercholesterolemia, morbid obesity. * any history of use xanthine oxidase inhibitors, antihypertensives, antiglycemic, and cholesterol lowering medications * any history of illicit drug use within the last 6 months

Keywords: prehypertension gout puls wave velocity hypertension 24 hour blood pressure
study of enteric-coated mycophenolate sodium (ec-mps) with steroid withdrawal vs ec-mps with standard steroid regimen in de novo renal transplant recipients.

Conditions: Kidney de Novo Transplant

Summary: all patients of the core study who are interested of being treated with ec-mps will be included in an open-label extension study to collect further information on the long-term safety, tolerability and efficacy of this drug. the purpose of this study is to evaluate the feasibility of steroid withdrawal in the setting of immunosuppression with a combination of ec-mps, cyclosporine and steroids in de novo kidney allograft recipients.


Eligibility criteria:
inclusion criteria * male or female patients undergoing first kidney transplant. * patients aged 18 -70 years. * patients receiving an abo identical or compatible graft. exclusion criteria * multi-organ recipients (e.g. kidney and pancreas) or previous transplant with any organ other than kidney. * positive hbsag test * pre-transplant pra \>50% or historical pra \>75% other protocol-defined inclusion/exclusion criteria may apply.

Keywords: kidney, de novo transplant, steroid withdrawal, adults, ec-mps and cyclosporine
darbepoetin alfa and anemia of cancer

Conditions: Anemia; Anemia of Cancer; Cancer; Carcinoma; Neoplasms; Non-Myeloid Malignancies

Summary: this phase 2, multicenter, randomized, open-label, comparative study was designed to determine the effect of darbepoetin alfa on hospital days, economic outcomes, and health related quality of life (hrqol) in anemic patients with nonmyeloid malignancies who were not receiving chemotherapy. participants were randomly assigned in a 4:1 allocation ratio to receive either 21 weeks of darbepoetin alfa treatment (treatment group) or 12 weeks of observation followed by up to 9 weeks of darbepoetin alfa treatment (observation group).


Eligibility criteria:
inclusion criteria: * nonmyeloid malignancies (including lymphocytic leukemias) * anemia (hemoglobin concentration less than or equal to 11.0 g/dl) due to cancer and/or previous chemotherapy or radiotherapy * eastern cooperative oncology group performance status of 0 to 2 * adequate liver and renal functions * 18 years or older exclusion criteria: * history of recombinant human erythropoietin therapy, cytotoxic chemotherapy, or more than 30 gy radiotherapy to the whole pelvis within 4 weeks before screening * acute myelogenous leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome * known hematologic disorders that could cause anemia * inflammatory or cardiac disorders * previous positive antibody response to any erythropoietic agent * history of pure red cell aplasia

Keywords: anemia of cancer darbepoetin alfa aranesp
effects of high intensity inspiratory muscle training on exercise capacity in patients with bronchiectasis

Conditions: Bronchiectasis

Summary: reduced exercise tolerance is commonly reported in patients with bronchiectasis. the purpose of this study is to evaluate the effects of high-intensity inspiratory muscle training (high-imt) and sham high-imt (control) on exercise capacity, respiratory muscle function (strength and endurance) and health related quality of life in patients with bronchiectasis.

bronchiectasis often demonstrates decreased exercise tolerance, marked dyspnea and fatigue. the causes are multifactorial and include altered pulmonary mechanics, inefficient gas exchange, decreased muscle mass, and psychological status, which all lead to a progressive detraining effect. essentially both the pathology and the functional manifestations of bronchiectasis increase the demand for inspiratory muscle work and that contribute to dyspnea and exercise limitation. in recent studies reduced strength of respiratory muscles are investigated in bronchiectasis and can be contribute the exercise limitation. additionally imt has shown to improve respiratory muscle function, exercise tolerance and dyspnea in patients with bronchiectasis. despite this, the number of studies are inadequate and so the optimal training protocol remains still to be defined. in this study the researchers want to investigate the effects of high-intensity inspiratory muscle training in functional results in patients with bronchiectasis.

Eligibility criteria:
inclusion criteria: * diagnosis of bronchiectasis with high resolution computed tomography * being 18-65 years of age * being able to walk and co-operate exclusion criteria: * acute exacerbation or change in drugs or usage of antibiotics in last 3 weeks * neurological disease, severe orthopaedic problem or advanced heart failure

Keywords: bronchiectasis high-intensity inspiratory muscle training
a trauma-informed intervention for positive youth development and teacher wellness in rural montana

Conditions: Depression, Anxiety; Stress

Summary: "a trauma-informed intervention for positive youth development and teacher wellness in rural montana" is intended to help mitigate stressors that may contribute to poor behavioral and mental health in rural montana teachers. the immediate goals of this study is to promote student health by supporting teacher wellbeing through a remotely-delivered trauma-informed yoga intervention.

project summary: "a trauma-informed intervention for positive youth development and teacher wellness in rural montana" is intended to help mitigate stressors that may contribute to poor behavioral and mental health in rural montana teachers. the immediate goal of this study is to promote student health by supporting teacher wellbeing through a remotely-delivered trauma-informed yoga intervention. specific aim: expansion of previous pilot study to teachers in the southwestern montana school district. methods: to explore scalability to rural communities without access to yoga instructors, we will implement a limited feasibility study of online yoga delivery to classroom teachers. this study will enroll a minimum 30 livingston teachers (taught trauma-informed yoga via zoom), twice weekly for 45-minute trauma-informed yoga sessions during the 6-week intervention period. no participants were assigned to the "no intervention" arm. to measure physical health outcomes, pre, mid-, and post-intervention cortisol testing will be utilized to evaluate any changes in teacher stress levels before and after the program. heart rate variability will also be assessed for teachers pre, mid-, and post-intervention using the heartmath inner balance ppg sensor and em wave pro plus software. to assess behavioral health, pre- and post-survey instruments will collect targeted wellness/mental health data from teachers. an adverse childhood experience self-reporting screener will also be given to participants to establish a baseline of exposure to childhood trauma, which is closely correlated with health outcomes. teachers will also complete the teachers' sense of self efficacy survey and the professional quality of life index, which are linked to teacher mental health, retention, and career satisfaction.

Eligibility criteria:
inclusion criteria: * any teacher currently employed by the livingston school district who wishes to participate in the intervention (up to 35 participants) exclusion criteria: * only teachers will be considered for this study (i.e., no school staff, administrators, etc.)
dementia care training with virtual reality and support for home care staff

Conditions: Dementia

Summary: this study aims to evaluate a dementia care training with virtual reality and peer support program on dementia care knowledge, attitude, care competence, work stress, and empathy of home care staff.

home care staff often have insufficient knowledge and skills of caring people with dementia at home. many lack empathy for those with dementia. training courses for home care staff often are not developed according to their educational background and workplace needs. this two-group cluster randomised controlled trial aims to evaluate a dementia care training with virtual reality and peer support program on dementia care knowledge, attitude, care competence, work stress, and empathy of home care staff. the dementia care training consists of dementia care e-books, dementia virtual reality activity and peer support program. the interventional group will receive a dementia care training using dementia care e-books, dementia virtual reality activity and peer support program. the control group will only receive dementia care e-books and peer support with no dementia virtual reality activity. both groups will be assessed for their dementia care knowledge, attitudes, care competence, work stress and empathy at baseline, month 3, and 6.

Eligibility criteria:
inclusion criteria: * age 20 to 65 years * taiwanese nationality * had worked as a home care staff for at least three months * had experience in providing home care for patients with dementia * had a mobile phone or tablet and regular access to the internet exclusion criteria: * home care staff who do not meet the inclusion criteria * can not provide informed consent.

Keywords: home care staff dementia care virtual reality
a study of macitentan in children below 2 years of age

Conditions: Arterial Hypertension, Pulmonary

Summary: the purpose of this study is to learn what happens to macitentan and its active metabolite (aprocitentan) in the body of children aged between 1 month and 2 years.


Eligibility criteria:
inclusion criteria: * pulmonary arterial hypertension (pah): 1) including participants with down syndrome. diagnosis must have been confirmed by (historical, any time before screening) right heart catheterization mean pulmonary arterial pressure (mpap) greater than or equal to (\>=) 25 millimeter of mercury (mmhg), pulmonary arterial wedge pressure (pawp) less than or equal to (=\ ) 3 wood units \* meter square (m\^2) where in the absence of pulmonary vein obstruction and/or significant lung disease pawp can be replaced left atrium pressure or left ventricular end diastolic pressure (in the absence of mitral stenosis) assessed by heart catheterization. a) idiopathic pah, or b) heritable pah, or c) pah associated with congenital heart disease: i) eisenmenger syndrome (qp/qs less than (\ 8 wu and qp/qs \<2), or iii) co-incidental shunt (that is, not explaining hemodynamically the presence of pah), or iv) post-operative pah (persisting/recurring/developing ≥ 6 months after repair of shunt), or d) drug or toxin induced pah, or e) pah associated with human immunodeficiency viruses (hiv) * world health organization functional class (who fc) i, ii, or iii * pah-specific treatment-naive participants or participants on pah specific monotherapy or combination of 2 therapies. use of macitentan before or during screening is allowed * body weight of greater than or equal to (\>=) 3.5 kilogram (kg) * parent(s) (preferably both if available or as per local requirements) or participant's legally designated representative must sign an informed consent form (icf) indicating that they understand the purpose of, and procedures required for, the study and is/are willing to allow the child to participate in the study exclusion criteria: * pah due to portal hypertension, schistosomiasis, pulmonary veno-occlusive disease and/or pulmonary capillary hemangiomatosis * persistent pulmonary hypertension of the newborn * the following congenital cardiac abnormalities: a) cyanotic congenital cardiac lesions such as transposition of the great arteries, truncus arteriosus, pulmonary atresia with ventricular septal defect, unless operatively repaired and with no residual shunt. b) univentricular heart and/or participants with fontan-palliation * pulmonary hypertension due to lung disease * known diagnosis of bronchopulmonary dysplasia
fractional photothermolysis for the treatment of burn scars

Conditions: Scar

Summary: the aim of our study is to determine the effect of fractional photothermolysis laser in the treatment of burn scars.

one of the main problems in the management of burned patients is the treatment of post-burn scarring. frequently this scars cover large areas, tend to retract, present pigmentary changes and are disfiguring, producing significant life quality impairment. unfortunately, there are very few therapeutic options for treating these scars, which can be secondary to reconstructive surgery or after spontaneous healing. in the last decades most reports in scar treatment have included, pressure garments, chemical peeling, dermabrasion, ablative and non-ablative laser therapy and surgery with varying degrees of success. there is only one report treating burn scars with fractional laser, with good results. the aim of our study is to determine the effect of of a second-generation erbium-doped 1,550-nm fractional photothermolysis laser (fraxel sr laser, reliant technologies inc.) in the treatment of burn scars.

Eligibility criteria:
inclusion criteria: * burn scars should be located on the anterior thorax or abdomen with at least 4 months of evolution. * the scar should be slightly elevated, with erythema and with no signs of keloid formation. * maximum scar dimension: 0.2 - 1% body surface area. * acceptance of informed consent for laser treatment. exclusion criteria: * previous non-surgical treatment (i.e. dermabrasion, laser, peelings, bleaching agent. etc). * previous surgical treatment (i.e. graft)

Keywords: scars secondary to injuries to tissues caused by contact with physical (heat, electricity) o chemical agent.
efficacy evaluation of dai dai flower on body weight

Conditions: Gastroenterology

Summary: to assess the dai dai flower extract on body weight control


Eligibility criteria:
inclusion criteria: * healthy male or female aged between 20 and 60 years old * body mass index (bmi) ≥ 24 (kg/m\^2) or body fat mass ≥ 25% exclusion criteria: * pregnant or breastfeeding woman * implementation in weight loss programs, consumption drugs or supplements for weight control before 3 months of this study * participate weight control or fat loss human studies before 3 months of this study * history of cardiovascular disease, liver disease, kidney disease, endocrine disease, or other major organic diseases (according to subjects reporting). * person who has received major surgery or bariatric surgery (according to medical history). * person who has received constant drug use. * people with mental illness

Keywords: obesity weight control dai dai flower
sglt2 inhibitors in treating patients with pcos

Conditions: Polycystic Ovary Syndrome

Summary: chronic inflammation is the core of polycystic ovary syndrome (pcos), and obesity and overweight further exacerbate the level of inflammation in the peripheral circulation and ovarian tissue in pcos patients. metformin is a classic endocrine drug for the treatment of pcos, but its clinical response rate is only about 40%. our previous published study (diabetes obes metab, 2022) observed that the new hypoglycemic drug sglt-2 inhibitor can significantly improve the clinical symptoms of patients with insulin resistance pcos, and the clinical efficacy is not inferior to metformin, but its specific mechanism of action is not clear. recent studies have shown that sglt-2 significantly attenuates the activation of the nod-like receptor protein 3 (nlrp3) inflammasomes and the secretion of il-1β in patients with type 2 diabetes mellitus at high risk of cardiovascular disease. based on the above research background, this project will combine clinical research and mechanism exploration to solve the following two problems: 1. whether sglt2 inhibitor can further improve the clinical efficacy of pcos patients compared to metformin; 2. mechanistic studies further clarify whether sglt2 inhibitors improve inflammatory symptoms by modulating nlrp3 inflammosomes in the treatment of polycystic ovary syndrome;

this clinical study is a prospective, single-center, randomized (1:1) controlled clinical study. the enrollment population is overweight or obese pcos patients. after signing the informed consent form, patients who meet the inclusion/exclusion criteria will be randomly assigned to the experimental and control groups for treatment in a 1:1 ratio, for a total of 108 patients enrolled. subjects randomized to the trial group will receive sglt-2 inhibitors for 24 weeks. participants randomised to control will receive metformin for 24 weeks.

Eligibility criteria:
inclusion criteria: * female aged 18-45 * meet rotterdam criteria * bmi≥20kg/m2 exclusion criteria: * treatment with any additional medications that might impede the trial, including glp-1 ras, metformin, pioglitazone, contraceptives, or traditional chinese medicine within the past 3 months * pregnancy or lactation * mental illness * malignant tumors * chronic kidney disease or severe liver dysfunction * inflammatory bowel disease * involvement in other research programs within the past 3 months
risedronate sodium in post menopausal osteoporosis

Conditions: Osteoporosis, Postmenopausal

Summary: the primary objective is to compare subject satisfaction of once a week dosing of 35 mg actonel to once daily dosing of 5 mg actonel in postmenopausal osteoporotic women. the secondary objectives are to measure compliance (50 % drug taken), and persistence, \[and urinary ntx (n-telopeptides) (optional)\].


Eligibility criteria:
inclusion criteria: * five years or greater postmenopausal who present with a diagnosis of postmenopausal osteoporosis based on standard clinical practice criteria. * subjects must discontinue bisphosphonates, calcitonin, fluoride, glucocorticoids (≥ 5 mg prednisone or equivalent per day) and hormone replacement therapy including estrogen-related compounds at least 6 months prior to randomization. during the study, these drugs are not permitted other than the study medication, actonel. * other concomitant medications should be kept to a minimum, but if the drugs are considered necessary for the subject's welfare and are unlikely to interfere with study medication, they may be given at the discretion of the investigator. exclusion criteria : * had a history of cancer within the past 5 years. relatively benign skin malignancies, such as basal cell carcinoma or squamous cell carcinoma, are not an exclusion criteria if the subject has been in remission for at least 6 months prior to enrollment. * diagnosis of hypocalcemia, hyperparathyroidism, and hyperthyroidism. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
prognosis of failure treatment of amebic liver abscess

Conditions: Amebic Liver Abscess

Summary: amebic liver abscess is the most frequent extra-intestinal form of the amoebiasis; actually the factors for predicting failure in the medical treatment are not clear. we conducted trial for determining the clinical value of paraclinical factor in this issue.


Eligibility criteria:
inclusion criteria: 1. clinical, ultrasonographic and serologic diagnosis (elisa) of amebic liver abscess. 2. both genders 3. older 15 years exclusion criteria: 1. clinically suspected piogenous liver abscess 2. positive hemoculture 3. negative elisa for amoebic antigens 4. immunosupresion (hiv) 5. abdominal or biliary surgery antecedents 6. abdominal neoplasia antecedents

Keywords: amebic liver abscess failure prognosis