Kornimate/medical-research-clean huggingface dataset:
sufentanil versus ketamine intranasally in the management of severe acute trauma-related pain in children.

Conditions: Traumatology; Wounds and Injury; Fractures Bone; Analgesia; Pain; Pain Management; Acute Pain

Summary: this study aims to compare two treatments for managing severe pain in children who have suffered trauma and are treated in pediatric emergency departments. specifically, it evaluates intranasal sufentanil (the experimental treatment) versus intranasal ketamine (the reference treatment). the study hypothesizes that sufentanil will be non-inferior to ketamine in terms of pain relief, with a goal of reducing the pain score by at least two points on the visual analog scale (vas) which ranges from 0 to 10. the study design is a randomized controlled trial involving 100 children, with 50 in each treatment group. children will be randomized upon their arrival in the emergency department, and both groups will be followed for one hour to monitor the effects. the primary outcome is effectiveness of pain control, with secondary objectives including the comparison of the time it takes for each treatment to take effect, the frequency of excessive sedation (measured using the ramsay scale), the tolerance of each treatment, the satisfaction of the parents, and the need for additional analgesics. this study is important because pain management in pediatric trauma cases is crucial, and there is a need for safe and effective treatments that are easy to admnister. by exploring the effectiveness and safety of sufentanil compared to ketamine, this research may provide valuable insights into pain management options for children in emergency settings.


Eligibility criteria:
inclusion criteria: * children aged 6 to 17 years inclusive, under 18 years old, weighing more than 10kg, and requiring analgesia for the management of acute pain * presenting with pain assessed as severe using a validated pain scale (vas ≥ 6/10) * pain caused by trauma, excluding thoracic trauma with dyspnea and abdominal pain * obtaining written and signe informed consent from one of the two parents or legal guardians * affiliation with a social security system * hemodynamically stable exclusion criteria: * patient in a state of immediate life-threatening distress * parents who don't understand and/or don't speak french * known hypersensitivity to opiods * allergy to one of the study treatments * history of epilepsy or known psychiatric illness * history of respiratory, cardiac or renal insufficiency * use of serotonergic antidepressants * any child with an ongoing respiratory condition (asthma, laryngitis) * thoracic trauma * use of opioids within the 4 hours prior to arrival in the ermergency department * any child with an ongoing respiratory condition (asthma, laryngitis) * thoracic trauma * use of opioids within the 4 hours prior to arrival in the ermergency department * history of head, abdominal, or spinal trauma * confirmed pregnancy * history of toxic substance use * facial or nasal trauma * whithdrawal of informed consent from the parents or legal guardian
pulse oximeter accuracy during stable hypoxia plateaus

Conditions: Healthy

Summary: this project aims to test the accuracy of pulse oximeters in the range of arterial hbo2 saturations from 100% down to 70%.

this project aims to test the accuracy of pulse oximeters in the range of arterial hbo2 saturations from 100% down to 70%. this is done by comparing the pulse oximeter reading during brief, steady state hypoxia plateaus with a gold-standard measurement of blood oxyhaemoglobin saturation.

Eligibility criteria:
inclusion criteria: * male or female, aged \>= 18 and \< 50. * subject in good general health with no evidence of any medical problems. * subject is fluent in both written and spoken english. * subject has provided informed consent and is willing to comply with the study procedures. exclusion criteria: * subject is obese (bmi \> 35). * subject has a known history of heart disease, lung disease, kidney, or liver disease. * diagnosis of asthma, sleep apnea, or use of cpap. * subject has diabetes. * subject has a clotting disorder. * subject has hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation. * subject has any other serious systemic illness. * subject is a current smoker. * any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators would interfere with the sensors working correctly. * subject has a history of fainting or vasovagal response. * subject has a history of sensitivity to local anesthesia. * subject has a diagnosis of raynaud's disease. * subject has unacceptable collateral circulation based on exam by the investigator (allen's test). * subject is pregnant, lactating, or trying to get pregnant. * subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures. * subject has any other condition, which in the opinion of the investigators would make them unsuitable for the study.
non contrast ct in acute appendicitis

Conditions: Acute Appendicitis

Summary: to evaluate diagnostic accuracy of non-contrast ct in correlation with ultrasound in diagnosis of acute appendicitis in adults

acute appendicitis is a prevalent cause of abdominal pain, with an estimated lifetime risk of 7 to 9%.\[1\] diagnosing appendicitis on ct has a sensitivity and specificity of 87% and 76%, respectively. classically, diagnosis of acute appendicitis is by identifying an enlarged appendix (greater than 6 mm in diameter) . some studies suggest using a cut-off value of over 7 mm to improve the prognostic capability of ct. on the other hand, appendicitis is regularly diagnosed using radiology studies. in fact, imaging is often the deciding factor between operative and non-operative management. though the diagnosis can be clinical following a thorough history and physical, imaging is regularly employed to confirm the diagnosis in question. the most commonly used radiographic study is the ct scan, given its speed, sensitivity, and specificity. us is also relatively useful modality to diagnose acute appendicitis, it has its limitations. ultrasound is highly operator dependent and tends to work best on individuals with less fat and muscle content in their abdomen (i.e., children). currently, the negative appendectomy is less than 12% in men but can be up to 33% in women; accurate imaging studies could reduce the number of unnecessary surgeries performed on patients. it is, therefore, essential to know which study will provide the clinician with the most accurate information for their specific clinical scenario.

Eligibility criteria:
inclusion criteria: * adult patient (male or female) with clinical suspicion of acute appendicitis . exclusion criteria: * pregnant ladies and patients with history of appendectomy
effect of chan-chuang qigong with breathing meditation on quality of life in patients with breast cancer

Conditions: Breast Cancer; Quality of Life; Intraoperative Awareness

Summary: the aim of this study was to evaluate the effect of the 15 weeks chan-chuang qigong program with breathing meditation on quality of life and interoceptive awareness in patients with breast cancer during chemotherapy.

cancer is the leading cause of death globally, and breast cancer is the number one threat to women's health worldwide. chemotherapy is the main adjunctive treatment for breast cancer. however, chemotherapy increasingly being employed in the management of breast cancer patients will cause physical and psychological discomfort as reported. the aim of this study was to evaluate the effect of chan-chuang qigong therapy with breathing meditation on quality of life and interoceptive awareness in breast cancer patients. this was a randomized controlled trial. participants were randomly assigned to the qigong group who received chan-chuang qigong therapy with breathing meditation for 15 weeks, and the control group who received routine care. the outcomes were measured by using the european organization for research and treatment of cancer quality of life questionnaire (eortc qlq-c30) and multidimensional assessment of interoceptive awareness (maia).

Eligibility criteria:
inclusion criteria: 1. aged ≥20 2. diagnosed with breast cancer (stages i and ii) 3. before receiving chemotherapy 4. conscious clear to communicate. exclusion criteria: 1. severe cardiopulmonary, liver or kidney dysfunction 2. the original law of qigong cases.
a randomized trial of interventions for teenage drivers with attention deficit hyperactivity disorder (adhd)

Conditions: Attention Deficit Hyperactivity Disorder

Summary: there is clear, converging evidence from multiple prospective studies with well-diagnosed adolescents with adhd and comparison, non-adhd adolescents, that teen drivers with adhd have more accidents and other adverse driving outcomes. available research indicates parental monitoring and limit-setting for adolescent drivers is one of the most effective interventions for preventing negative driving outcomes. for children with adhd, interventions to promote parenting capacity to effectively oversee and intervene in teen driving will likely need to be intensive and require multiple treatment components. the present proposal aims to compare the standard care for teen drivers (driver's education classes and driving practice) to the supporting a teen's effective entry to the roadway (steer) program, that includes a parent-teen intervention, adolescent skill building, parent training on effective adolescent management strategies, joint parent-teen negotiations sessions, practice on a driving simulator, parental monitoring of objective driving behaviors, and the targeting of safe teen driving via contingency management strategies (i.e., parent-teen contracts). to facilitate teen and parent engagement the intervention will be preceded by a motivational interview. the specific aims of the proposal are to investigate the efficacy of the steer program relative to a standard care group in a randomized clinical trial (n=172) on measures of objective driving outcome and parenting capacity. it is hypothesized that the steer program will result in improved outcomes relative to the standard care group at the end of intervention and 6 and 12 month follow-up assessments.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of adhd, combined type * at least 16 years old * has a driving permit exclusion criteria: * no parent willing to be involved * seizure disorder, eating disorder, psychotic disorder, current diagnosis of substance/alcohol dependence * prior driver's education class

Keywords: adhd driving behavior modification
comparing previously placed nephrostomy tract (nt) versus single stage percutaneous nephrolithotomy (pcnl)

Conditions: Urolithiasis

Summary: the investigators are trying to determine whether placement of a nephrostomy tube prior to definitive stone surgery and under ultrasonic or fluoroscopic guidance will reduce complications related to bleeding and infection compare to obtaining renal access at the time of surgery.

we seek to identify whether the placement of a nephrostomy tract prior to surgery versus at the time of pcnl will: 1. decrease blood loss and related complications, and 2. decrease infection-related complications by providing the ability to an accurate collection of urine for culture and initiating appropriate antibiotic treatment prior to definitive stone management. in addition, we seek to determine whether renal puncture under fluoroscopic vs ultrasonic guidance is associated with less blood loss. although retrospective studies have shown some benefit to placing the nephrostomy tube prior to surgery in terms of decreased blood loss, there are no well-designed, prospective studies comparing the two treatment approaches. we seek to determine which treatment approach is safer, more efficacious, and more cost-effective through a prospective, randomized trial.

Eligibility criteria:
inclusion criteria: * patients age 18 years to 90 years old, * patients with stone disease * patients who hoose to have pcnl for treatment * patients who understand the informed consent exclusion criteria: * minors * unable to understand the informed consent * unwilling to fill out the sf 36 questionnaire

Keywords: renal stones
hodgkin lymphoma molecular profiling and clinical outcomes in u.s. community oncology practices

Conditions: Hodgkin's Disease

Summary: the purpose of this study is to gather data on patients diagnosed with and treated for classical hodgkin lymphoma (chl). it aims to closely observe how treatment for chl is rendered, as well as assess the outcome of those treatment options and their impact on quality of life. additional analyses will also attempt to identify prognostic or predictive biomarkers


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * histologically confirmed diagnosis of classical hodgkin lymphoma (chl) * patients who are treatment-naïve, or are within ± 2 weeks beginning any line of therapy at time of enrollment * patients must be within ± 2 weeks of day 1 of the first cycle of any line of therapy to enroll; a cycle is practice-defined for chemotherapy, targeted therapy, or immunotherapy-based regimens. * any eastern cooperative oncology group (ecog) or karnofsky performance status (ps) * patients must have available medical records for the date of diagnosis of chl and available medical records documenting any prior treatment and treatment dates for the hodgkin lymphoma, including chemotherapy, radiation, surgery and other anti-cancer therapy received. * patients must consent for use of their ffpe tissue blocks for exploratory analyses exclusion criteria: * patients on supportive care only and not receiving anti-cancer therapy are not eligible to enroll * patients with unknown date of diagnosis of chl * patients whose prior chl therapy, and dates of therapy (eg, surgery, radiation, or drug therapy) are unknown * any other non-hl (non-hodgkin lymphoma) active malignancy for which the patient is receiving treatment * patients participating in a clinical study that does not allow enrollment into a non-interventional study * patients enrolled who go on to receive only supportive, palliative, hospice, or end-of-life care remain on study and should not be discontinued from follow-up. other protocol defined inclusion/exclusion criteria could apply
safety and feasibility study of autologous bone marrow cell transplantation in patients with peripheral arterial occlusive disease (paod)

Conditions: Arterial Occlusive Diseases

Summary: patients with peripheral artery disease, stage iii or iv who are not candidates for interventional or operative therapy should be treated with intraarterial progenitor cell therapy (autologous bone marrow cells) in a randomized, placebo controlled trial.

main goal: improvement of limb perfusion (ankle brachial index). secondary aims: reduction of pain reduction of ulcer size walking distance improvement in tissue oxygenation (tco2) minor or major amputation

Eligibility criteria:
inclusion criteria: * patients with paod (stage iii or iv) * distal arterial occlusions * patients with buergers disease * signed informed consent exclusion criteria: * successful bypass operation or intervention within the last 3 months * active infection, feber, chronic inflammatory disease * hiv, hepatitis * tumor within the last 5 years, complete remission required * stroke or myocardial infarction within last 3 months * renal insufficiency (creatinine \> 2 mg/dl) * liver disease (got \> 2x upper limit oder spontaneous inr \> 1,5). * anemia (hemoglobin \< \<10 mg/dl) * thrombocytopenia \< 100.000/µl * allergies to aspirin, clopidogrel, heparin * bleeding disorder * gastrointestinal bleeding within last 3 months * surgery or trauma within the last 2 months * pregnancy * mental retardation * inclusion in other clinical study within last 30 days

Keywords: critical limb ischemia peripheral arterial occlusive disease [c14.907.137]
early precut in difficult biliary cannulation

Conditions: Common Bile Duct Diseases

Summary: this study evaluates whether an early precut strategy in cases of difficult biliary cannulation could reduce the incidence of pep compared with that after prolonged cannulation attempts. secondary aims are to compare the success of biliary cannulation and complications rates of the two techniques.

in this prospective multicenter randomized clinical trial the investigators assign patients referred for therapeutic biliary ercp and difficult biliary cannulation (unsuccessful cannulation after 5 minutes) to early precut (group a) or repeated papillary cannulation attempts followed, in case of failure, by late precut (group b). group a patients undergo precut immediately after randomization ("early precut"), while for group b cannulation attempts are continued for another 10 minutes, after which a precut is done if these fail or there are three unintended additional passages of the guide-wire into the mpd ("delayed precut").

Eligibility criteria:
inclusion criteria: * 18 to 85 years of age who were scheduled to undergo therapeutic biliary ercp. exclusion criteria: * active cholangitis or pancreatitis * chronic pancreatitis, * previous sphincterotomy, * prior gastric surgery, * coagulopathy, * severe comorbidity (need for tracheal intubation) * patients who refused or were unable to give informed consent. * patients with successful cbd cannulation within 5 minutes of standard attempts and fewer than three passages of the guidewire into the main pancreatic duct (mpd) (arbitrarily defined as "easy cbd cannulation"), * detection of ampulloma or peri-papillary diverticula during ercp.
detection of intravascular injection between blunt and sharp needles during cervical transforaminal epidural block.

Conditions: Pain; Radicular; Neuropathic, Cervical

Summary: this study evaluates the incidence of intravascular injection during cervical transforaminal epidural block using blunt needle, compared to the sharp needle. the investigators will performed cervical transforaminal epidural block using blunt-type block needle in half of participants or sharp-type block needle in the other half.

cervical transforaminal epidural block is an effective treatment option of radiating pain. there are potential risks associated with transforaminal epidural block such as infection, dural puncture, bleeding, and intravascular injection. although the risk is low, intravascular injection should be carefully monitored because intravascular injection of particulate steroids can cause fatal neurologic deficits such as spinal infarction and cerebral infarction. the incidence of intravascular injection during transforaminal epidural block with real time fluoroscopy guidance depends on spinal level. the previous studies using real time fluoroscopy demonstrated that the incidence of intravascular injection of cervical transforaminal epidural block is higher than that of lumbosacral transforaminal epidural block. in this study, therefore, the investigators investigate the incidence of intravascular injection during cervical transforaminal epidural block using blunt needle, compared to the sharp needle.

Eligibility criteria:
inclusion criteria: * patients with radiating pain from cervical spinal stenosis and herniated nucleus pulposus. exclusion criteria: * pregnancy, allergic to contrast media, patient refusal, and patients with persistent contraindication to nerve block such as coagulopathy and infection of the injection site.
positron emission tomography imaging of brain amyloid in normal pressure hydrocephalus

Conditions: Normal Pressure Hydrocephalus

Summary: to determine the level of association between the quantitative estimates of brain uptake of \[18f\]flutemetamol and the quantitative immunohistochemical and histochemistry estimates of amyloid levels in frontal lobe biopsy samples obtained from subjects during shunt placement for nph.


Eligibility criteria:
inclusion criteria: * the subject is at least 50 years of age. * the subjects' general health is adequate to comply with study procedures. * the subject has been scheduled for a shunt placement procedure for the treatment of nph. exclusion criteria: * the subject has a contraindication for mri or pet. * the subject is pregnant or lactating. * the subject has a known or suspected hypersensitivity/allergy to \[18f\]flutemetamol or to any of the excipients. * the subject has participated in any clinical study using an investigational agent within 30 days of dosing.

Keywords: amyloid normal pressure hydrocephalus (nph) positron emission tomography (pet) standard uptake value ratios (suvr)
the effect of doctor-nurse-patient cooperative analgesic linkage program on movement evoked pain

Conditions: Pain, Postoperative; Anaplasia

Summary: 1. to establish doctor-nurse-patient cooperative analgesic linkage program. 2. evaluate the effect of doctor-nurse-patient cooperative analgesic linkage program on movement evoked pain after laparotomy for patients with hepatobiliary and pancreatic disease through quasi-experimental study.

part i the establishment of doctor-nurse-patient cooperative analgesic linkage program 1. based on literature review and clinical investigation results, initially make a doctor-nurse-patient cooperative analgesic linkage program through discussion in experts consensus meeting. 2. using delphi method, determine the doctor-nurse-patient cooperative analgesic linkage program after two rounds consultation. part ii clinical application study of doctor-nurse-patient cooperative analgesic linkage program. conduct non-randomized control study in corresponding period. 80 patients from two wards which managed by the same medical and nursing team were divided into experimental and control group. patients in the control group were received routine post-operative analgesia pump and analgesics, and functional rehabilitation, while ones in the experimental group were received doctor-nurse-patient cooperative analgesic linkage program. evaluate the effect of pain control during rehabilitation, adverse events during rehabilitation, patients' satisfaction of pain control.

Eligibility criteria:
inclusion criteria: * consent to the study. * normal cognitive ability and speak chinese * patients received selective laparotomy under general anesthesia. * length of stay is longer than three days. * patients who are allowed to do rehabilitation. exclusion criteria: * patients with severe organic disease, chronic pain, history of brain injury, history of drug or alcohol addiction. * psychiatric patients * consciousness disorder * patients contradict to opioid medications

Keywords: movement evoked pain analgesia general surgery hepatobiliary and pancreatic disease