Kornimate/medical-research-clean huggingface dataset:
the relationship between umbilical cord ph and feto-maternal doppler studies in scheduled nonlaboring term singleton caesarean deliveries

Conditions: Fetal Hypoxia; Fetal Conditions

Summary: perinatal asphyxia is a crucial reason for neonatal and childhood morbidity and death. fetal and neonatal acidemia can be utilised as predictors for establishing such risk. several researches have reported a marked relation between low values of fetal ph with short- and long-term adverse neonatal outcomes. umbilical cord blood gas studies (ucgs) are considered critical data that gives an objective and certified evaluation of the oxygenation and metabolic status of the fetus. before birth, the physician can evaluate fetal wellness through cardiotocography and prenatal ultrasound. other studies had examined the role of fetal doppler indices before birth and proposed that fetuses with lower impedance in the middle cerebral artery (mca) or low cerebroplacental ratio (cpr) are at increased risk of adverse pregnancy outcome. however, no research has ever evaluated the possibility of a correlation between ultrasonographic fetal evaluation and fetal umbilical cord ph as a predictor of pre-delivery fetal ph. the goal of our study was to discovered a potential association between the venous umbilical ph cord blood at delivery and the ultrasonographic feto-maternal doppler indices in patients with a scheduled nonlaboring term singleton caesarean deliveries (scd), this research is a novel finding.

the investigators included in our study only singleton term (37 0/7 - 41 6/7 weeks of gestation) pregnancies delivered by a scheduled nonlaboring term singleton caesarean deliveries. this was an observational study carried out at a single university tertiary care center for every patient, an ultrasound examination was performed within one day of delivery and the fetal doppler indices were recorded. the umbilical venous ph were obtained immediately after delivery and before placental detachment with heparinized syringes the primary endpoints were cpr, umbilical (ua) and fetal mca arteries indices. the second endpoints analysed when measurable were ductus venosus (dv) and uterine artery (ut) pulsatility indices, all indices were examined using colour doppler ultrasound according to a standard procedure and cpr was evaluated as the ratio between the mca and ua pulsatility indices. the venous umbilical cord ph at birth was correlated with ultrasound doppler parameters, calculating the correlation coefficient r2 and p-value. statistical significance was fixed at p\<0.05. the investigators performed a linear regression analysis to find the association between the different ultrasound indices and the venous ph.

Eligibility criteria:
inclusion criteria: * singleton term (37 0/7 - 41 6/7 weeks of gestation) pregnancies delivered by a scheduled nonlaboring term singleton caesarean deliveries exclusion criteria: * pregnancies complicated by fetal malformations, stillbirth, preterm deliveries.

Keywords: fetal doppler ultrasound exam cesarean delivery umbilical cord ph scheduled cesarean delivery cerebroplacental ratio
comparison of the effects of indacaterol and tiotropium on inspiratory capacity

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study compared the effects of a single dose of indacaterol with that of a single dose of tiotropium on inspiratory capacity.


Eligibility criteria:
inclusion criteria: * diagnosis of moderate (as classified by the global initiative for chronic obstructive lung disease \[gold\] guidelines, 2007) chronic obstructive pulmonary disease (copd) and: 1. smoking history of at least 10 pack-years. 2. forced expiratory volume in 1 second (fev1) \< 80% and ≥ 50% of the predicted normal value. 3. post-bronchodilator fev1/force vital capacity (fvc) \< 0.7. exclusion criteria: * patients who have had a copd exacerbation requiring systemic glucocorticosteroid treatment or antibiotics and/or hospitalization in the 6 weeks prior to screening. * patients who have had a respiratory tract infection within 6 weeks prior to screening. * patients with concomitant pulmonary disease. * patients with alpha-1-antitrypsin deficiency. * patients with contraindications for tiotropium treatment. * patients with a history of hypersensitivity to any of the study drugs or to drugs from similar drug classes. other protocol-defined inclusion/exclusion criteria applied to the study.

Keywords: copd indacaterol tiotropium
autologous adipose derived mesenchymal stem cells (amsc) in reducing hemodialysis arteriovenous fistula failure

Conditions: End Stage Renal Disease (ESRD); Vascular Access Complication

Summary: the aim of this phase 1 study is to determine the role of autologous adipose derived mesenchymal stem cells in the reduction of hemodialysis arteriovenous fistula failure when applied during the time of surgical creation.


Eligibility criteria:
inclusion criteria * patient between 18 and 85 years old * patient currently on hemodialysis or pre-dialysis and planned creation of an upper extremity av fistula with suitable anatomy * ability to communicate meaningfully with investigative staff, competence to give written informed consent, and ability to comply with entire study procedures * life expectancy of at least 24 months exclusion criteria * malignancy or treatment for malignancy within the previous 6 months * immunodeficiency including aids / hiv or active autoimmune disease * documented hypercoagulable state or history of 2 or more dvts or other spontaneous intravascular thrombotic events * pregnancy or breast feeding * treatment with any investigational drug/ device within 60 days prior to study entry or any other condition which in the judgment of the investigator would preclude adequate evaluation of the safety and efficacy of amscs and the avf * employees of the sponsor or patients who are employees or relatives of the investigator * history of failed organ transplant on immunosuppression
functional connectivity & stimulation-enhanced therapy post stroke

Conditions: Stroke

Summary: after stroke, it is common for individuals to experience hand impairment. this deficit can severely restrict functional ability and independence. recovery of hand function following stroke is highly variable. in this study, the investigators will use brain imaging to predict individual response to treatment. survivors of stroke will receive upper extremity therapy while they concurrently receive imperceptible vibration to the wrist aimed to enhance therapy outcomes.

the ability to predict individuals' responses to treatment can enable effective allocation of a treatment to likely responders. the long-term goal is to determine whether acute changes in brain functional connectivity immediately after one treatment session can predict ultimate gains in motor function after completing multiple treatment sessions. the objective of this study is to determine feasibility and to examine association between change in brain functional connectivity after one session and motor gains after completion of all treatment sessions. this study is a prospective single-cohort longitudinal study. the treatment is task-practice therapy (3d/wk, 18-session) accompanied with concurrent imperceptible wrist vibration that is intended to prime the cortical sensorimotor network and enhance hand functional recovery in chronic stroke survivors. hand function will be assessed before/after therapy and at 1-month follow-up. connectivity will be assessed using fmri and eeg before and after a treatment session.

Eligibility criteria:
inclusion criteria: * age = 18 or older * at least 6 months post-stroke * moderate upper limb impairment with the ability to participate in hand task practices * fingertip touch sensory deficits (e.g., monofilament\>2.83, 2-point discrimination\>5mm, sense of numbness, tingling) exclusion criteria: * complete upper limb deafferentation * rigidity (modified ashworth scale=5) * botulinum toxin injection within 3 months prior to enrollment or during enrollment * brainstem stroke * comorbidity (peripheral neuropathy, orthopaedic conditions in the hand that limit ranges of motion, premorbid neurologic conditions, compromised skin integrity of the hand/wrist due to long-term use of blood thinners) * concurrent upper extremity rehabilitation therapy * language barrier or cognitive impairment that precludes following instructions or providing consent * mri incompatible.

Keywords: hand function occupational therapy physical stimulation
cavity evaluation before intracytoplasmic sperm injection

Conditions: Infertility

Summary: uterine cavity evaluation is an integral part of assessment of women for icsi

transvaginal us is the main role in this aspect

Eligibility criteria:
inclusion criteria: * women with infertility more than one year exclusion criteria: * 2omen with medical disorders
seroprevalence of sars-cov-2 antibodies in children

Conditions: COVID; Corona Virus Infection; Multisystem Inflammatory Syndrome in Children

Summary: it is unknown what proportion of healthy children have been exposed to sars-cov-2 and how many have antibodies. the aim of this study is to follow a cohort of healthy children over six months and measure their antibodies to sars-cov-2.

coronaviruses are non-segmented positive-stranded rna viruses with a roughly 30 kb genome. the majority of coronaviruses cause disease in a specific host species but some have infected humans by cross-species transmission. this process has led to a number of severe outbreaks of human disease including severe acute respiratory syndrome (sars) in 2003 and middle east respiratory syndrome (mers) in 2012. from december 2019 a novel infection "severe acute respiratory syndrome coronavirus 2" (sars-cov-2) was identified in the wuhan region of china. the infection was identified as the causal factor in a growing number of severe cases of pneumonia. this disease was subsequently named coronavirus disease 2019 (covid-19) by world health organisation (who). sars-cov-2 has been shown to cause severe disease similar to the previous sars coronavirus from 2003. severe disease is associated with pneumonia and damage to vital organs including lung, heart, liver, and kidney. fortunately sars-cov-2 appears to cause only mild, or no, symptoms in children. the social distancing measures in the united kingdom include the closure of schools and the cancelling of routine paediatric clinics. these drastic, but necessary, steps are likely to have a profound effect on the well-being of children. this study is required to determine what proportion of children have been exposed to sars-cov-2 and how many, if any, have neutralizing antibodies. the findings from this study could be used to inform public health decisions regarding the re-opening of schools and other services vital to the well-being of children. in addition the study will recruit children with paediatric multi-system inflammatory syndrome admitted to the royal belfast hospital for sick children along with matched controls with other infections.

Eligibility criteria:
healthy children of healthcare professionals. exclusion criteria: not currently receiving antibiotics, not admitted to hospital within the last seven days, not receiving immunosuppressive drugs and never diagnosed with a malignancy. admitted children with paediatric multisystem inflammatory syndrome and admitted children with other serious infections.

Keywords: antibodies
a comparison of iv versus po acetaminophen postoperatively for opioid consumption after cesarean section

Conditions: Postoperative Pain; Cesarean Section; Acetaminophen

Summary: this randomized controlled study will compare narcotic consumption between two groups: patients that receive a perioperative dose of iv acetaminophen versus patients that receive a perioperative dose of oral liquid acetaminophen for scheduled cesarean section.

"enhanced recovery" is an alternate management protocol described by a multi-modal, evidence based approach to peri-operative care, with the goal of accelerating recovery and return to normal activity after surgery. results have shown stable pain control with a decrease in narcotic consumption, a quicker return of bowel function, and decreased length of hospital stay and cost with no change in level of patient satisfaction, morbidity, or readmission rate. an aspect of some alternate management protocols is the administration of acetaminophen. the concentration of acetaminophen in cerebrospinal fluid (csf) is directly proportional to the analgesic activity of acetaminophen. acetaminophen relies on a high concentration gradient from the plasma to the csf in order to passively diffuse into the central nervous system (cns), its principal site of action. a 2012 study, comparing plasma and csf pharmacokinetics of intravenous (iv), oral (po), or rectal (pr) acetaminophen, concluded that iv administration of acetaminophen results in higher plasma and csf concentration values. therefore, iv acetaminophen produces better cns penetration compared to po or pr methods.

Eligibility criteria:
inclusion criteria: * women age 18 or older * scheduled to undergo a cesarean section exclusion criteria: * existing diagnosis of chronic pain * need to undergo a vertical skin incision * aspartate aminotransferase (ast) \> 50, alanine aminotransferase (alt) \> 70 * platelets below 80,000 on admission * need to undergo general anesthesia * tubal ligation at time of cesarean section * prior or known allergy to any of the medications being utilized in this study

Keywords: humans female pregnancy acetaminophen narcotics patient satisfaction cesarean section pain postoperative period
rfa for superficial lipomas

Conditions: Lipoma

Summary: lipomas are non-cancerous growths of fatty tissue that develop under the skin in approximately 1 in 1000 people, though this number may be higher. while rarely symptomatic, they often cause emotional distress due to the unappealing appearance of the mass. treatment of unsightly lipomas is excision with local anesthetic in the office or with sedation in the operating room. the recovery period is short and the procedure is low risk; however, the result of the operation is a visible scar over the site of the lipoma. many patients defer surgical excision because excision of a lipoma is a cosmetic procedure, but the aesthetic outcome is undesirable. radiofrequency ablation (rfa) is a technique that applies heat generated by a high frequency, alternating current to soft tissue. the hyperthermia produced by the current causes tissue necrosis that ablates the tissue into which the energy is directed. rfa has been successfully applied to thyroid nodules, pancreatic lesions, esophageal dysplasia and liver tumors. however, the manufacturers of the rfa technology have been focused on its application in pre-malignant and malignant lesions and have not yet considered its application to benign tumors. this study will test the success of rfa for superficial lipomas as a non-surgical option for treatment.


Eligibility criteria:
inclusion criteria: * patients \>18 years old * patients with a lipoma \<5 cm, above the fascia on the trunk, abdomen or extremities exclusion criteria: * lipomas of the face or neck * angiolipomas (identified on exam as a firm, mobile, occasionally discolored mass) * patients with history of hereditary retinoblastoma, li-fraumeni syndrome, familial adenomatous polyposis, neurofibromatosis, tuberous sclerosis and werner syndrome * a history of exposure to herbicides, arsenic and dioxin * a history of radiation treatment for other cancers

Keywords: lipoma ablation fatty tissue fatty tumor scarring minimally invasive
sensitivity of forced oscillation technique in children with asthma and normal spirometry

Conditions: Asthma in Children

Summary: exhibiting variable airway obstruction is a key factor in the diagnosis of asthma but too often it is undetected by spirometry. study hypothesis: the forced oscillation technique (fot) will show airway obstruction in asthmatic children with normal spirometry pointing out its advantage in measuring aw obstruction in this population. we will conduct a prospective observational study in 6-18 years old children with the diagnosis of asthma and a normal spirometry results. each subject will undergo evaluation including: asthma control questionnaire, spirometry, fot and fractional exhaled nitric oxide (feno) to assess the sensitivity of fot in diagnosing airway obstruction in this circumstances.

background: asthma diagnosis and control are based on history of recurrent typical symptoms and variable airflow obstruction by by measuring maximal expiratory flows with spirometry. however, in many children with asthma spirometry can be normal. the forced oscillation technique (fot) is a simple, noninvasive technique performed during tidal breathing that is relatively easy to apply. the objective of this study is to assess the sensitivity of fot in children with asthma and normal spirometry. study design: this will be a prospective observational study. population: 6-18 years old children visiting the pediatric pulmonary clinic at the investigators institution with the diagnosis of asthma and normal spirometry results (fev1 \& fev1/fvc \>80% and fef25-75\>65%) either on treatment or before treatment. study protocol: after obtaining written informed consent, participants will fill asthma control questionnaires. family history and risk factors for asthma will be reviewed. data on blood eosinophils and skin prick test for allergy will be collected from the medical files. medication (controller and reliever) will be also documented. fot will be measured using the tremoflo c-100 airwave oscillometry system (thorasys , montreal, quebec, canada). r5, r20, r5-20 (resistances at the reported frequency), x5 (reactance at 5hz), ax5 (reactance area at 5hz), fres (resonance frequency) will be reported. fractional exhaled nitric oxide (feno) will be measured using the single breath exhalation technique.

Eligibility criteria:
inclusion criteria: * diagnosis of asthma * must be able to perform spirometry and fot tests * normal spirometry results (fev1 \& fev1/fvc \>80% and fef25-75\>65%) exclusion criteria: * chronic lung disease other than asthma * severe chronic medical condition such as heart failure, neuromuscular disease etc.

Keywords: forced oscillation technique airway obstruction asthma
photo biomodulation therapy for alveolar osteitis recovery in oral contraceptive users

Conditions: Alveolar Osteitis

Summary: does laser effect on alveolar osteitis recovery in oral contraceptive users ?

photo biomodulation therapy for alveolar osteitis recovery in oral contraceptive users

Eligibility criteria:
* inclusion criteria: female patients aged 25-40 years. currently using oral contraceptives for at least 3 months prior to participation. diagnosed with dry socket (alveolar osteitis) based on clinical criteria. * exclusion criteria: presence of systemic diseases (e.g., diabetes, immunodeficiency disorders). smoking or tobacco use. allergies to zinc oxide or other study materials. use of antibiotics or anti-inflammatory medications within the last 2 weeks. pregnancy or breastfeeding.

Keywords: alveolar osteitis and oral contraceptive
postprandial lipid metabolism in patients with hypertriglyceridemia and normo-lipidemic controls: medium chain fatty acids (mct) in comparison to long-chain, saturated fatty acids (sfa) and mono-unsaturated fatty acids (mufa)

Conditions: Hypertriglyceridemia

Summary: postprandial lipid metabolism will be evaluated in patients with hypertriglyceridemia and normo-lipidemic controls; different fats will be used (saturated fatty acids, mon-unsaturated fatty acids and medium chain fatty acids) for the oral fat challenge.


Eligibility criteria:
inclusion criteria: * hypertriglyceridemia (150 mg/dl-900 mg/dl) exclusion criteria: * lipid lowering drugs or indication for lipid lowering drugs * ldl-cholesterol \> 190 mg/dl * diabetes mellitus
effects of terlipressin when usual somatostatin or octreotide dose fails

Conditions: Liver Cirrhosis; Esophageal and Gastric Varices; Hemorrhage

Summary: to observe and access the effects and safety of terlipressin or high dose somatostatin/octreotide when usual dose somatostatin/octreotide fail to achieve hemostasis in patients with acute variceal bleeding.

the prognosis information of the patients with acute variceal bleeding will be collected, including hemostasis rate, early rebleeding rate, mortality, complications, severity adverse events, economic burdens and quality of life, when terlipressin or high dose somatostatin/octreotide is used as salvation to patients fail to achieve initial hemostasis.the results may help gastroenterologists to make decisions when administering vasoactive medicines to those suffered from acute variceal bleeding.

Eligibility criteria:
inclusion criteria: * cirrhosis patients admitted to emergency department because of acute variceal bleeding exclusion criteria: * no signs of variceal bleeding are found by endoscopy or portal hypertensive gastropathy is responsible for the bleeding * patients undergo endoscopy after 72h from the beginning of acute variceal bleeding * patients with hepatorenal syndrome * patients with ischemia organic cardiopathy (including myocardial infarction or unstable angina pectoris) or myocardial ischemia indicated by ecg in the past 6 months * patients allergic to/with contraindications of vasoactive drugs

Keywords: acute variceal hemorrhage terlipressin somatostatin octreotide comparative effectiveness research
constraint-induced movement therapy and self-regulation for children with cerebral palsy

Conditions: Cerebral Palsy

Summary: this study examines the effect of combining modified constraint-induced movement therapy (mcimt) and self-regulation (sr) in promoting upper limb function of children with hemiplegic cerebral palsy (cp) studying in a school-based setting.

children diagnosed with hemiplegic cp are involved. a within-subject design is used with children acting as their own controls. the study is scheduled at three-week intervals. all children undergo conventional occupational therapy (ot) and modified constraint-induced movement therapy plus self-regulation (mcimt + sr) program in a random order. both programs last for three weeks. each program is followed by a three-week no-treatment period to measure the carry-over effect. the ot program consists of training on unimanual and bimanual tasks for 1 to 2 hours a week with daily home exercise. the mcimt + sr program involves restraint of the unaffected upper limb of children using a cotton sling for 6 hours per day for 15 days. a one-hour structured task practice with the use of sr is provided during each 6-hour restraint. the bruininks-oseretsky test of motor proficiency, the jebsen-taylor test of hand function, the caregiver functional use survey, a hand dynamometer, pinch gauge, and modified ashworth scale are used for evaluation. all children are assessed for five times at 3-week interval: once before and twice after the conventional ot; and twice after the mcimt + sr at 1 week and at 3 weeks. before and after the three-week intervention, the children participate in event-related potentials (erp) sessions with a choice reaction task. event-related potentials (erp) technique is used to capture the changes in neural mechanism after intervention.

Eligibility criteria:
inclusion criteria: * children with diagnosis of hemiplegic cp, * 6-18 years of age studying at local special school for students with physical handicap (ph), * intelligence ranging from normal to mild grade mental retardation, * the ability to extend the wrist at least 20° and the metacarpophalangeal joint 10° from full flexion, and * no balance problems sufficient to compromise safety. exclusion criteria: * any health problems that were not associated with cp, and * severe muscle tone with modified ashworth scale scored greater than 3.