Kornimate/medical-research-clean huggingface dataset:
serum vasohibin, cardiotrophin, endocan & perinatal outcomes

Conditions: Preeclampsia; Gestational Hypertension; Gestational Diabetes; Preterm Birth; Fetal Growth Retardation

Summary: investigation of the relationship between maternal serum vasohibin-1, vasohibin-2, cardiotrophin -1 and endocan concentrations at the 11th and 14th weeks of gestation and adverse perinatal outcomes.

previous animal model studies in the literature have shown that vasohibin-1 released in endothelial cells inhibits angiogenesis, while vasohibin-2 stimulates angiogenesis. additionally, immunohistochemical studies have shown that vasohibin-2 plays a role in the cellular fusion of trophoblasts in the placenta to form syncytiotrophoblasts. studies in the literature have shown that cardiotrophin-1 is expressed in cardiac myocytes and vascular endothelial cells and stimulates the synthesis and secretion of endothelin-1 in endothelial cells through the gp130 signaling pathway. since endothelin 1 plays an important role in the regulation of vascular tone, cardiotrophin-1 can be considered to act as an endothelium-derived biological factor, possibly involved in the regulation of vascular tone under normal physiological conditions or secondary to pathological processes. studies in the literature have shown that maternal serum endocan levels are higher in pregnant women whose pregnancies were complicated by preeclampsia than in normotensive pregnant women, and that the endocan molecule may be effective in the etiopathogenesis of preeclampsia, especially if it develops early. in the light of this above-mentioned information, we aim to investigate whether serum vasohibin-1, vasohibin-2, cardiotrophin-1 and endocan concentrations measured during the 11th to 14th weeks of pregnancy can be used to predict preeclampsia, gestational hypertension, fetal growth restriction, preterm birth and gestational diabetes mellitus.

Eligibility criteria:
inclusion criteria: * those who had the first-trimester screening test between 11 and 14 weeks of pregnancy and are in the low-risk group * those with singleton pregnancy * those who did not conceive pregnancy with assisted reproductive treatment methods * those who do not have any pregestational diseases * those who do not have any uterine anomalies exclusion criteria: * smokers * those who are in the high-risk group with the first trimester screening test * those with multiple pregnancies * those who conceive with assisted reproductive treatment methods * those who had any disease before pregnancy * those who have any uterine anomalies
effect of the natural sweeteners erythritol and xylitol on gut microbiota and glucose metabolism in obese volunteers

Conditions: Obesity

Summary: sugar alcohols such as xylitol and erythritol are increasingly popular as sugar substitutes in the food industry and are also recommended to diabetic patients. both substances are already in use in the food industry and are freely available. since the 1970s, beneficial effects on oral health could be demonstrated as oral bacteria were influenced positively. animal studies showed an increase in gut clostridium perfringens after xylitol intake; certainly a non-desirable effect. however, studies on effects of erythritol and xylitol on the human gut microbiota are lacking so far. in this trial, investigators aim to examine whether gut microbiota and glucose tolerance can be influenced by polyol intake in a non-diabetic but obese cohort.


Eligibility criteria:
inclusion criteria: * obese volunteers (bmi \> 30kg/m2) * aged 18- max. 55 years * otherwise healthy. exclusion criteria: * known cardiovascular disease * diabetes mellitus * arterial hypertension with medication * dyslipidaemia with medication * known chronic hepatic disease (nash, hepatitis). * known renal disease: kidney failure * pregnancy * intake of proton pump inhibitors (ppis) on a regular basis * intake of antibiotics within the last 3 months before inclusion * intake of pro or prebiotics * chronical diseases of the gastrointestinal tract, history of gastrointestinal surgery with major changes to the gastrointestinal tract * substance abuse, alcohol abuse. * inability to follow procedures due to psychological disorders, dementia or insufficient knowledge of project language (german).
efficacy and safety of 308-nm excimer lamp combined with tacrolimus vs tacrolimus as monotherapy in treating vitiligo on children

Conditions: Vitiligo; Pediatric ALL; Dermatologic Disease; Autoimmune Diseases

Summary: vitiligo is a auto immune that impact 2% of the global population, regardless from the phototype. even though it affects patients in a physical way through loss of pigmentation, it is also impacting them on a mental/emotional way.11-12 current treatments offer a symptomatic solution to patients, however the response rate can be low and results can be slow. pediatric patients in vitiligo deserves special care as frequently (50%), the disease onset is before 20 years of age and, in 25% of the cases, it starts before the age of 10 years.13 also, the current treatments for children are limited since it can involve pain and claustrophobia. the combination therapy of the study could offer a painless and easy treatment to follow. if the combination of those two therapies can fasten and improve the response rate, this could be a good option to treat this condition not only in children, but also for adults patients.


Eligibility criteria:
inclusion criteria: * vitiligo and surface area involved of less than10% who are being followed in the outpatient dermatology clinics of king abdullah university hospital (kauh) * 6 weeks wash out period from previous treatments will be employed to eliminate any effect from such treatments exclusion criteria: * skin dermatoses with kobner phenomenon * lupus erythematous * pacemakers * hyper-photosensitivity * melanoma and non-melanoma skin cancers * drugs with photosensitizer side effect * radiotherapy * pregnancy (by principle, nno study available) * diseases that are contagious by contact

Keywords: vitiligo excimer 308nm
restoring the anatomic tension relationship of the long head of the biceps during tenodesis

Conditions: Biceps Tendon Disorder; Tendinosis; Rotator Cuff Injuries

Summary: the goal of this clinical trial is to determine the clinical impact of restoring the anatomic-tension relationship of the long head of the biceps (lhb) when performing a biceps tenotomy and tenodesis. the main question it aims to answer is whether anatomic tensioning will improve functional outcome scores and decrease postoperative complications. the investigators hypothesize that through a standardized method of anatomically tensioning the lhb tendon during tenodesis, patient outcomes will improve. researchers will compare these outcomes to a control group receiving the traditional tensioning technique. participants will be randomized to either the anatomic tensioning treatment group or the traditional tensioning control group.

the long head of the biceps can be a source of anterior shoulder pain that is primarily due to inflammation or instability of the long head of the biceps (lhb) tendon . patients that fail non-operative management become candidates for biceps tenotomy and tenodesis. currently, there is no universal protocol or gold standard for how the lhb tendon is tensioned. at the investigators' institution, the lhb is tensioned based on individual surgeon feel for the correct tensioning. the purpose of this study is to conduct a randomized, single-blinded prospective study comparing patients with the current regimen of bicep tensioning vs. utilizing a standardized method of anatomically tensioning the lhb tendon. the primary aim of assessing change in the american shoulder and elbow surgeon (ases) scores from baseline to post-surgery between the control and intervention groups will be assessed using a student's t-test. in addition, longitudinal mixed effects models will be used to estimate changes in ases scores, over all time-points using a random effect for surgeon. other relevant patient characteristics such as age, sex, and charlson score will be included to explore the adjusted relationship of the intervention and outcomes over time. a secondary aim of this study is to collect specific measurements of the myotendinous junction of the lhb tendon to potentially establish if any characteristics predispose patients to developing pathology of the lhb tendon.

Eligibility criteria:
inclusion criteria: * patients at least 18 years of age undergoing arthroscopic shoulder surgery * operations that occur at loyola university medical center (maywood, il), loyola ambulatory surgery center (maywood, il), or gottlieb memorial hospital exclusion criteria: * previous shoulder surgery involving the long head of the biceps tendon * younger than 18 years old * current pregnancy. as per standard protocol with all surgeries, a urine pregnancy test is performed prior to surgery. if positive, the surgery will be cancelled and the patient will be excluded from the research study.
multicenter prospective evaluation of the incidence and serotyes of invasive pneumoccocal disease (ipd) among children below 5 years

Conditions: Pneumococcal Disease

Summary: the purpose of this study is to identify the s. pneumoniae serotypes strains and to determine antibiotic susceptibility.


Eligibility criteria:
inclusion criteria: * age less than 5 years exclusion criteria: * none

Keywords: laboratory based study antibiotic susceptibilty invasive strains
the effect of mobile lymphedema self-care support program on self-care in women with breast cancer-related lymphedema

Conditions: Breast Cancer Related Lymphedema

Summary: the aim of this randomized controlled study is to evaluate the effect of the mobile lymphedema self-care support program on self-care, quality of life and symptoms related to lymphedema in women with breast cancer-related lymphedema. h1: there is a difference between the lymphedema self-care scale mean score in women who develop lymphedema due to breast cancer, according to the use of the mobile lymphedema self-care support program. h2: there is a difference between the lymphedema quality of life scale average score in women who develop lymphedema due to breast cancer according to the status of using the mobile lymphedema self-care support program. h4: there is a difference between lymphedema arm circumference measurements according to the use of the mobile lymphedema self-care support program in women who develop lymphedema due to breast cancer. h5: in women who develop lymphedema due to breast cancer, there is a difference in the situation of experiencing symptoms related to lymphedema according to the use of the mobile lymphedema self-care support program.

the content of the mobile program was developed by the researchers. the mobile lymphedema self-care support program content was reviewed by an expert group consisting of doctors, physiotherapists and nurses working with patients with lymphedema. patients will be contacted via telephone and will be informed about the study, and the experimental and control groups will be selected through the randomization program among the patients who agree to participate in the study and meet the sampling inclusion criteria. patients were blinded, and blindness will be achieved in the data analysing stage. all measurements will be made to the experimental and control groups at the same time. the standard lymphedema self-care training will be given to the experimental and the control group. and the experimental group will be educated on how to use the mobile program. when the study is completed, the control group will also be allowed to use the mobile program.

Eligibility criteria:
inclusion criteria: * diagnosed as breast cancer-related lymphedema * literate, * having a smart phone, * completed breast cancer treatment at least six months ago * volunteering to participate in the study exclusion criteria: * having morbid obesity * having metastazis * having dementia * having other psychiatric conditions * another health problem that could prevent to exercise * not using smart phone

Keywords: self-care mobile application quality of life patient education symptoms breast cancer related lymphedema
serum opiorphin level after intraoperative intravenous lidocaine infusion

Conditions: Cancer, Breast

Summary: a prospective, double blinded and randomized study included women with breast cancer and underwent mastectomy, and randomly allocated into two groups of equal size. lidocaine group and control group.

women aged between 18 and 60 years old with breast cancer and underwent mastectomy, asa i or ii were included in the study. * group i (lidocaine): patients were received intravenous 1 mg/kg of 2 % lidocaine as a loading dose (just before induction of anesthesia) then received 2mg/kg /h lidocaine as maintenance dose (with maximum of 200 mg/h) till the end of the operation (skin closure). * group ii (control):- a standardized equal volume of intravenous bolus dose of normal saline was given as loading dose then normal saline was administered on an equal rate of infusion.

Eligibility criteria:
inclusion criteria: * women aged between 18 and 60 years old with breast cancer and underwent mastectomy, american society of anesthesiologist i or ii exclusion criteria: * patients with contralateral breast cancer, metastatic tumor, morbid obesity (bmi\> 40), allergy to an amide local anesthetic, or morphine sulphate, heart block, renal, or liver dysfunction, or substance abuse disorder, or chronic opioid use
etiological study of persistent velopharyngeal insufficiency in children with operated velopalatine cleft by analysis of velopharyngeal motor skills in static and dynamic mri

Conditions: Velopharyngeal Insufficiency; Real Time MRI; Cleft Palate

Summary: velopharyngeal insufficiency is defined as the inability of the soft palate to isolate the nasopharynx from the oropharynx. it is a frequent sequela in patients with a velopalatine cleft despite anatomical restoration of the soft palate by intravelar veloplasty at 6 months. if rehabilitation by a speech therapist is not successful, a pharyngoplasty can be discussed. in the last ten years, mri was used in dynamic and static way, to analyzed velopharyngeal muscles, in particular levator veli palatini. mri could be used to identify the etiology of vpi in those patients, and thus allow personalized rehabilitation and surgical management. the aim of this study is to examine the differences in velopharyngeal motricity as well as velar muscles morphology, positioning, and symmetry of children with repaired cleft palate with different degrees of severity of velopharyngeal insufficiency (vpi), and children with labial cleft (noncleft palate anatomy).


Eligibility criteria:
inclusion criteria: * children aged 7 to 12 years with isolated cleft lip * isolated velopalatal cleft * without a diagnosis of syndromic cleft or pierre robin sequence * french speaking, and french is the native language * operated with a cheiloplasty (for cleft lip) or an intravelar veloplasty (according to sommerlad) at the amiens university hospital * whose follow-up is done at the amiens university hospital exclusion criteria: * refusal of the parents and/or the patient * with a contraindication to mri * whose follow-up was initiated in another center and/or whose surgery was performed in another center * whose surgical schedule has not been followed * patient with severe neurological or neuropsychiatric disorders or severe speech and language delay not related to the cleft anatomy * patients treated with fixed, non-removable orthodontic treatment.

Keywords: velopharyngeal insufficiency real time mri cleft palate
inhaled ciclesonide for outpatients with covid19

Conditions: COVID 19

Summary: the contain (ciclesonide clinical trial covid-19 treatment) is a randomized control study of ciclesonide vs placebo for mild covid-19 disease. the need for potential therapy for covid-19 patients is urgent. ciclesonide has shown encouraging in vitro results, is easy to be used and is readily available. it has a low rate of side effects and few interactions with other drugs. it is unusual to use an inhaled steroid drug for covid-19 but there has been new data suggesting steroids may have an antiviral effect in addition to an anti-inflammatory effect. investigators propose to use inhaled and nasal ciclesonide to stop viral replication in the nose and airways. investigators hope this will accelerate recovery from covid-19 illness in individuals who are not admitted to hospital at time of diagnosis of covid-19.


Eligibility criteria:
inclusion criteria: symptomatic adult patients positive by pcr for covid-19 within 5 days of enrollment with fever, cough, or shortness of breath. provision of informed consent at day 0, patients should be at home exclusion criteria: * already on inhaled corticosteroid medication * currently using systemic steroids (oral or intravenous or intramuscular such as prednisone) or use of steroids 7 days prior to enrolment * severely ill patients at enrollment (i.e., admitted to icu at admission) * unable to self-administer the inhaler * known or suspected pregnancy and breastfeeding * known allergy to study medication or its components (non-medicinal ingredients; including lactose allergy (type i)) * patients with untreated fungal, bacterial, or tubercular infections of the respiratory tract * current hospitalization * current use of oxygen at home or in the hospital
drinking effect of electrolyzed alkaline reduced water on oxidative stress and fatigue after intense exercise

Conditions: Oxidative Stress

Summary: the goal of this clinical trial is to test the drinking effect of electolyzed alkaline reduced water (arw) generated from alkaline ionizer (cgm mwpi-2101) on oxidative stress and fatigue after high-intensity exercise in healthy people. the main question\[s\] it aims to answer are: * \[question 1\] can ph 9.5 earw reduce oxidative stress compared to purified water (pw) * \[question 2\] can ph 9.5 earw decrease fatigue markers in blood participants will drink water from the experimental device after high-intensity exercise. blood sample will be collected before exercise, after highly intensive exercise, and after then 15 min. of drinking water. researchers will compare earw group and pw group to see the anti-oxidative and anti-fatigue effects.

this study was designed as a randomized, controlled, crossover, double-blind clinical trial with a single intervention of arw intake (ph 9.5, 10 ml/kg body weight) after highly intense exercise. the participants were divided into two groups, wherein they consumed either puriﬁed water (pw group) or earw (earw group). blood samples were collected before exercise, immediately after exercise, and 15 min after drinking water. for the anti-oxidative effect, ros, no, gpx, and mda levels were measured. for the anti-fatigue effect, latate, lactate dehydrogenase, phosphate and calcium were measured.

Eligibility criteria:
inclusion criteria: * healthy male participants aged 19-25 years * physically active with a normal body mass index (bmi) * had not smoked for 3 months or consumed alcohol for more than a week prior to the start of the study. exclusion criteria: * any kind of visible or known disease * hypertension, * musculoskeletal injuries in the previous three months, * breathing difﬁculties, * metabolic diseases, * autoimmune disease, * rash, * urticaria.
aliskiren versus ramipril on antiproteinuric effect in hypertensive, type 2 diabetic patients with microalbuminuria

Conditions: Hypertension; Type 2 Diabetes

Summary: the main objective of this study is to assess the extent and trend in time of antiproteinuric effect as well as that antihypertensive effect of aliskiren 300 mg / d versus ramipril 10 mg daily in hypertensive patients with type 2 diabetes and microalbuminuria. the investigators will also evaluate: 1. average of 24 hours, as determined by abpm, systolic and diastolic blood pressure checks at various visits 2. average daytime, as determined by abpm, systolic and diastolic blood pressure checks at various visits 3. average night, as determined by abpm, systolic and diastolic blood pressure checks at various visits


Eligibility criteria:
inclusion criteria: * blood pressure \> 130/80 \<180/105 mmhg at the end of the wash-out * type 2 diabetes mellitus well controlled by medication and / or compliance with diet (hba1c \<7%) * microalbuminuria in the upper range of normal (\> 200 \<300 mg/24 h) exclusion criteria: * pregnancy, lactation or women of childbearing age * sitting diastolic blood pressure e 105 mmhg or systolic pressure e 180 at the end of the period of wash-out * history of hypertensive encephalopathy or cerebrovascular accident within 6 months * secondary hypertension * heart failure * myocardial infarction within 6 months * angina pectoris, clinically significant valvular disease or arrhythmia * alteration indices of liver function or renal * known hypersensitivity to ace inhibitors * all other physiological or pathological condition in the opinion of the physician may affect the evaluation of the parameters under study

Keywords: hypertension type 2 diabetes aliskiren ramipril microalbuminuria blood pressure> 130/80 <180/105 mmhg at the end of the wash-out type 2 diabetes mellitus well controlled by medication and / or compliance with diet (hba1c <7%) microalbuminuria in the upper range of normal (> 200 <300 mg/24 h)
promising initial experience with intra-operative fluorescent cholangiography

Conditions: Gall Stone Disease

Summary: intraoperative fluorescent cholangiography (ifc) with concomitant fluorescent angiography is a recently developed method for non-invasive visualisation of the relevant anatomy during laparoscopic cholecystectomy. the objective of this study was to assess the time required by routine-use of ifc and to evaluate success-rate of the procedures. methods thirty-five patients scheduled for laparoscopic cholecystectomy and operated by the same surgeon were consecutively enrolled. a standardized protocol with ifc including concomitant angiography was performed during laparoscopic cholecystectomy. intra-operative time-registration and exposure of predefined anatomical structures were recorded.


Eligibility criteria:
inclusion criteria: * age \> 18 years * scheduled for acute- or elective laparoscopic cholecystectomy * informed consent exclusion criteria: * known iodine-hypersensitivity * liver- or renal insufficiency * known thyrotoxicosis * pregnancy or lactation

Keywords: fluorescent cholangiography laparoscopic cholecystectomy
an efficacy and safety study of sodium oligomannate (gv-971) for the treatment of alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the primary purpose of this study is to confirm the clinical efficacy and mechanism of action of gv-971, and identify incidence of known adverse reactions in long-term use and observe new adverse reactions, providing more guidance for clinical use.


Eligibility criteria:
inclusion criteria: * mild to moderate ad per nia-aa. * history of cognitive and functional decline over at least 1 year. * mmse scores between 11 and 24 (inclusive) at baseline. * hachinski ischemic score (his) scale total score ≤ 4. * hamilton rating scale for depression/17 items (hamd) total score ≤ 10. * brain mri scan show the highest possibility of ad. * have a reliable study partner/caregiver. * sign the informed consent form. exclusion criteria: * diagnosis of a dementia-related central nervous system disease other than ad. * major structural brain disease as judged by mri. * a resting heart rate of \< 50 beats per minute (bpm) after 10 minutes of rest. * major medical illness or unstable medical condition within 12 months of screening. * concomitant use of donepezil, rivastigmine, galanthamine, huperzine a, memantine, or aducanumab within 6 moinths prior to baseline. * inadequate hepatic function. * inadequate organ function. * ecg clinically significant abnormalities.