Kornimate/medical-research-clean huggingface dataset:
improve mental health and emotional labor among nurses who care the end-of-life patients

Conditions: End-of-life; Depression, Anxiety

Summary: cbt: cognitive behavioural therapy mbt: mindfulness-based therapy

nurses caring for terminally ill patients suffer from negative emotions and emotional labor, which may lead to a decline in the quality of end-of-life care. cbt and mbt are currently two commonly used psychological methods. they can be effective in improving bad mood. however, to the best of our knowledge, no investigators have used cbt and mbt among nurses caring for terminally ill patients. could cbt and mbt be effective in alleviating the psychological distress of these nurses? which psychological method is more effective?

Eligibility criteria:
inclusion criteria: * (1) eligible participants were the nurses who nursing patients with stage iv cancer or other incurable diseases; * (2) agree to participate in this research; * (3) no history of mental illness. exclusion criteria: * none
effect of systemic cooling in vasospasms

Conditions: Vasospastic Syndrome

Summary: this study tests whether women with vasospastic syndrome (vs) react more intensive than controls with distal vasomotions and choroidal blood flow changes to internal cooling/warming and external cooling/warming.

distal vasomotions and choroidal blood flow changes to internal cooling/warming and external cooling/warming was studied in vs and controls.core cooling was induced by drinking of 250g ice/water mixture (4°c). core warming was induced by drinking of 250g warm water (55°c). the study was controlled with respect to posture and room temperature.

Eligibility criteria:
inclusion criteria: * women * luteal phase or contraceptives * 19-35 years exclusion criteria: * somatic diseases * psychiatric diseases * bmi \> 25 * bmi \< 18

Keywords: vasospastic women controls core cooling core warming external cooling external warming ldf choroidal blood flow temperature vasospastic subjects normal subjects
effectiveness of multimedia exposure in patients transferred to hospital suffering from acute myocardial infarction

Conditions: Myocardial Infarction, Acute; Anxiety State; Emergencies

Summary: randomised clinical trial, single-center, blinded assessment, controlled with standard practice with two-group parallel design. eligible patients are those assisted and transferred suffering from st-elevation myocardial infarction in an advanced life support ambulance from an public emergency medical service in the cadiz area (spain). experimental group will watch an ad hoc design multimedia content in a tablet (video with sound and subtitles) during the transfer and control group will be assisted as standard procedures. main outcome variables will be conformed by patient reported outcomes (anxiety state, pain and comfort) and patient experience (transfer experience).

due to intrinsic characteristics of ambulance transport raises stress or anxiety in patients. moreover, other outcomes such as pain and some specific vital signs are affected. in the last years, empowerment patient strategies have been launched in several clinical settings but none in the er field. main objective comparative assessment of the effectiveness of multimedia exposure vs standard clinical procedures to improve the experience and patient reported outcomes in patients suffering from st-elevation myocardial infarction transferred to hospital in an advanced life support ambulance for a percutaneous coronary intervention (pci). methods randomised clinical trial, single-center, blinded assessment, controlled with usual practice with two-group parallel design. eligible patients are those assisted and transferred suffering from stemi in an advance life support (als) ambulance from public emergency medical system in the cadiz region. experimental group will watch multimedia content on a tablet (movie or image with sound) ad hoc designed, control group will be assisted as usual procedures. main outcomes will be conformed by informed patient results (anxiety state, pain and comfort) and patient experience (transfer experience).

Eligibility criteria:
inclusion criteria: * all genders patients. * assisted by als ambulance. * diagnosed with stemi, "killip i". * transferred by an ambulance to the hospital to receive a percutaneous coronary intervention. * informed consent must be signed. * conscious and oriented patients. exclusion criteria: * sedation and/or assisted ventilation. * blinded or visual defects. * deafness. * severe mental disorders or behavior disorders.

Keywords: ambulances video
technology supported education program based on human care theory

Conditions: Stem Cell Transplantation; Nursing Caries

Summary: hematopoietic stem cell transplantation is applied in the childhood age group for many reasons such as hematological malignancies, immune deficiencies, hemoglobinopathies, bone marrow failures and congenital metabolic diseases. the transplantation process, which requires a long hospitalization process, is an experience that causes anxiety for the child and the caregiver.

it is known that during the home care process after discharge, parents experience anxiety because they are away from health professionals, and they need information and support in their care needs. this research has two purposes. 1; developing a technology-supported home care education program (ibk-ebp) (supported by face-to-face education and mobile application) based on human theory of care (ibk) for home care of children with hematopoietic stem cell transplantation. 2; it is to determine the effect of ibk-ebp education program on parents' knowledge, self-efficacy, anxiety level and quality of life. the study was planned in a single-center, follow-up, double-blind, randomized controlled design. the research sample was planned to be composed of 40 parents, 20 of which were interventions and 20 of which were controls. the home care training program, which will be prepared with up-to-date information in line with the literature; it includes face-to-face training sessions and ensuring the continuity of education at home with the mobile application to be developed. the content of the home care training program to be prepared in this context; regulation of the home environment, compliance with treatment, food safety, personal hygiene and care, social environment, planning of school life and progressive relaxation exercises. as part of the training program, parents will be shown a cd of progressive relaxation exercises before the training. research data will be collected by a nurse other than the researchers, who was not involved in the study. research data will be collected using the "parent and child identification form", "parent's knowledge level of care assessment form", "general self-efficacy scale", "quality of life scale for caregivers of cancer patients" and "spielberger state and trait anxiety inventory". with a technology-supported home care education program to be developed based on the human care theory it is predicted that the knowledge, self-efficacy, quality of life of the parents will increase and the level of anxiety will decrease, by ensuring the ease and continuity of access to information.

Eligibility criteria:
inclusion criteria: * primary care parent of the child (0-18 years old) after hsct * having mobile internet access * discharge planned exclusion criteria: * parent's failure to attend at least 3 sessions of the training program

Keywords: caregiver parent stem cell transplantation self-efficacy quality of life theory of human caring
home-based gait rehabilitation service using the insole-type gait analysis device for children with cerebral palsy

Conditions: Gait Disorders, Neurologic; Cerebral Palsy

Summary: walking is a crucial daily activity that requires complex coordination of muscular systems. it is essential for bone and muscle health, cardiovascular fitness, and activities of daily living, making it an important indicator of prognosis and patient function. insole gait analysis devices are affordable and easy to use, and they align well with standardized 3d gait analysis. however, their use outside of hospital settings is limited. this study aims to assess the usability and satisfaction of utilizing insole gait analysis devices for monitoring and providing feedback on the walking status of children with cerebral palsy exhibiting walking impairments in a home environment. additionally, adherence to a home-based exercise program developed in this study will be evaluated.

the screening test is conducted after obtaining consent, and it involves assessing whether the subject can independently walk more than 10 meters, regardless of the use of assistive devices, following an evaluation of their baseline symptoms and signs. subjects who pass the screening test are provided with information about their current walking status and what constitutes normal walking. following the initial evaluation, they are instructed to participate in the 6-week home exercise program and how to record an exercise log. additionally, researchers provide participants with an insole gait analysis device and instruct them on its operation, encouraging prolonged usage to ensure that usage time and walking patterns are recorded. based on the collected measurement data, feedback is provided over the phone at weeks 3 to 4. after completing the 6-week home exercise program, a final evaluation is conducted in the same manner as the initial evaluation. satisfaction with the insole gait analysis device is assessed only at the time of the final evaluation. usage and satisfaction with the insole gait analysis device will be analyzed, and evaluation indicators will be compared before and after the home exercise program. additionally, adherence to the home exercise program will be evaluated through exercise logs.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with cerebral palsy aged 7 to 18 years old 2. patients classified as gross motor function classification system level 1 or 2 3. individuals who visited severance hospital, comprehended the study, agreed to participate, and submitted the informed consent form exclusion criteria: 1. individuals with complications such as severe foot deformities where the sensors of the insole gait analysis device cannot be recognized 2. in addition to above, individuals with clinically significant findings deemed inappropriate for this study by the study director or person in charge based on medical judgment

Keywords: gait parameters smart insole home-based exercise monitoring system rehabilitation
role of positive affect in adjustment to hiv

Conditions: HIV Infections

Summary: the purpose of this study is to examine the role of emotion and mood in the context of hiv.

a growing body of literature indicates that positive affect may have a unique adaptive role in the process of adjustment to chronic stress, independent of the effects of negative affects like depression. the overarching goal of this research is to provide evidence and direction for the development of interventions for people with hiv that include a focus on positive affect. to this end, this study will document the occurrence, predictors, and consequences of positive affect during the 18 months post-notification of hiv+ serostatus.

Eligibility criteria:
inclusion criteria: * have been informed they were hiv positive within the past two months * speak english * be 18 years or older * have the ability to provide informed consent to be a research participant exclusion criteria: * severe cognitive impairment * active psychosis

Keywords: hiv coping emotion affect hiv infection complimentary therapies
comparative pain control between 0.2 or 0.3 spinal morphine and 0.25 or 0.5 % bupivacaine for fnb after tka

Conditions: Post Operative Pain; Total Knee Replacement

Summary: comparative efficacy of 24 and 48 hours post operative pain control in single total knee replacement between intrathecal bupivacaine with 0.2 or 0.3 mg morphine together with 0.25 or 0.5 % bupivacaine for single femoral nerve block


Eligibility criteria:
inclusion criteria: * single elective total knee replacement in asa 1-3 without significant cardiovascular limitation exclusion criteria: * patient at risk in usage cox-2 for post operative pain control
the significance of sodium balance and the value of salt-blood test in identifying salt sensitive patients

Conditions: Hypertension,Essential

Summary: this is a randomized controlled trial with 72 patients with hypertension examining the effects on blood pressure of sodium restriction and whether the blood analysis salt-blood test is associated to a decrease in blood pressure. patients will be randomized 2:1 to either sodium restriction or usual diet for 4 weeks. baseline measures will be done before intervention and outcome measures after the 4 weeks.


Eligibility criteria:
inclusion criteria: * bmi ≤ 35 kg/m2 * essential hypertension * egfr \> 15 ml/min/1,73m2 * albumine-to-creatinine-ratio \< 500 mg/g * safe anticonception if women in childbearing age. * able to adhere to dietary regimen exclusion criteria: * secondary hypertension * clinically significant heart failure (nyha 3-4) * clinically significant liver disease * diabetes mellitus (type 1 and 2) * active cancer (except skin cancer) * renal transplant * recent stroke, transcient ischemic attack or myocardial infarction (within 6 months) * proliferative glomerulonephritis or anca-related disease * continuous immunosuppressant treatment * pregnancy or lactation * alcohol abuse * if the investigator finds the participant unfit to complete the project

Keywords: salt sensitivity sodium sensitivity salt restriction salt-blood test dietary intervention hypertension
effect of forced-air warming and circulating-water mattress in preventing heat loss during vascular surgery

Conditions: Hypothermia; Vascular Surgery; Forced-air Warming Mattress; Circulating-water Mattress

Summary: the purpose of this study is to determine whether a custom-made forced-air warming mattress can prevent heat loss in patients undergoing vascular surgery better than a circulating-water mattress

a reusable, custom-made forced-air warming mattress was made of a light to medium weight water resistant canvas, sewn like mattress with 2 arms placed underneath the patient. an open hole at proximal part of one arm was designed to attach with a hose of warm air delivery device. small holes (2-3 mm2), 5 inches apart were punched on the upper surface of this mattress around the patient except for the area underneath the patient that the holes were 9 inches apart. the weight of the patient will obstruct the air flow and prevent direct blowing of warm air onto the underside of patients. there is a special appendage connected to the upper part of mattress which can connect warm air to cover the patient's chest. there is a special appendage connected to the upper part of mattress which can convect warm air to cover the patient's chest. the mattress is 97 inches x 97 inches, with 2 arms of 25 inches x 16 inches and a special appendage of 45 inches x 12 inches for covering the chest with warm air delivery. this size is proper for patient of 170 cm. height. in order to reuse it, the mattress can be washed, dried and sterilized by gas or autoclaved for more than 50 times. a sterile sheet well enhance the sterile environment of the operating field.

Eligibility criteria:
inclusion criteria: patients undergoing vascular surgery exclusion criteria: preoperative fever

Keywords: hypothermia vascular surgery forced-air warming mattress circulating-water mattress
prediction of ssri treatment in major depression.

Conditions: Major Depression

Summary: this project will combine the data collected from eeg, eye tracking, structural and functional mri scans and neuropsychological performance from patients with major depression receiving ssri treatment. the purpose of this research is to predict the success of the ssri treatment and to categorize patients into sub-groups according to similar patterns of brain activation to personalize treatment.

major depression is a mood disorder affecting 350 million people worldwide. the disorder is characterized by depressed mood, anhedonia, decreased quality of life, deficits in cognitive functions and even suicide thoughts. treatment of depression is often a long process and includes taking different types and quantities of medications. therefore, there is a need to predict the success of the ssri treatment. our research will examine the outcomes of the combined technologies: bna (eeg), eye-tracker, structural and functional mri scans and neuropsychology tasks in patients with depression while receiving ssri treatment. the purpose of the research is to track biomarkers and other measures, which will allow predicting the ssri treatment's success within 4 weeks instead of 8 weeks. in addition, the investigators will attempt to categorize patients into different subgroups according to their brain activation and eye movements. this division into subgroups may contribute to the understanding of the mechanisms that account for the responsiveness to ssri treatment and to the possibility of targeting patients with depression towards a particular treatment. from this research, the investigators aim to personalize the treatment of depression, make it more efficient and reduce the amount of time for the patient to reach an optimal responsiveness.

Eligibility criteria:
inclusion criteria: 1. patients 18-65 years old 2. male and female 3. ability to comprehend and sign informed consent 4. dsm-5 diagnosis with mini 7.0.2 (healthy subjects need to be ruled out) inclusion criteria for patients with depression: 1. dsm-5 diagnosis 2. 0-2 failed treatments 3. patients which will start ssri treatment exclusion criteria: 1. unconsciousness 2. pregnancy or nursing 3. cardiovascular instability 4. metabolic instability (water, electrolytes, sugar) 5. fever or evidence of microbiological pollutant 6. deafness or blindness 7. schizophrenia 8. addiction disorders 9. eating disorders 10. bi-polar disorder 11. cognitive deficits 12. start a new psychotherapy during the research 13. unable to enter the mri scanner

Keywords: major depression eeg eye tracker fmri mri resting state connectivity cognition
study of elobixibat (a3309) in patients with chronic idiopathic constipation

Conditions: Constipation; Chronic Constipation

Summary: the purpose of this trial is to determine the efficacy and safety of a3309 administered to patients with chronic idiopathic constipation.


Eligibility criteria:
inclusion criteria: * patient meets protocol specified criteria for constipation * patient has successfully completed study requirements with no clinically relevant findings for physical exam, ecg, laboratory tests and colonoscopy as applicable exclusion criteria: * medical history or medical condition that would not make the patient a good candidate for the study or limit the patient´s ability to complete the study * patient reports loose stools * patient has ibs with pain/discomfort as predominant symptom * patient needs medications prohibited as specified in the protocol

Keywords: chronic idiopathic constipation a3309
comparison of purse-string closure versus conventional primary closure following stoma reversal to reduce surgical site infection rate"

Conditions: Surgical Site Infection; Difference in Surgical Site Infection According to Gender and Age Groups

Summary: the study will be carried out in surgical unit-iii, lahore general hospital, lahore for one year . . patients undergoing surgery for ileostomy will be randomly divided into two groups, group-a (purse-string closure) and group-b (conventional primary closure). all the patients will be called for follow up checkup on 14th days after operation and after one month. both of the groups will be checked and recorded for ssi after operation and hospital stay.

the study will be carried out in surgical unit-iii, lahore general hospital. it will be a randomized control trial. patients undergoing surgery for ileostomy were randomly divided into two groups, group-a (purse-string closure) and group-b (conventional primary closure). all the patients will be called for follow-up checkup on 14th days after operation and after one month. both of the groups will be checked and recorded for ssi after operation and hospital stay. the data will be statistically analyzed by using spss v23.0.t test (independent sample) used for the comparison of hospital stay mean. chi-square will also used for the comparison of the frequencies of ssi. data were stratified for gender and age. a p-value ≤0.05 will be considered as significant.

Eligibility criteria:
inclusion criteria: * included in the study 1. patients of both gender 2. patients ages between 25-70 3. patients undergoing surgery for having ileostomy for benign disease of intestine (as per operational definitions). exclusion criteria: * following patients were excluded 1. patients with pre-existing stomal site wound infection 2. reversal of stoma through laparatomy 3. post-operative anastomotic leak 4. ureamic patients 5. patients on chemotherapy and radiations
a longitudinal evaluation of oculometric measures and clinical assessment over time in pd patients

Conditions: Parkinson Disease

Summary: this is a prospective study in a cohort of about 30 patients with idiopathic parkinson's disease, who will be evaluated with a clinical assessment and an oculometric examination during a time period with specific intervals. this study aims to evaluate the correlation between oculometric measures and clinical assessment over time.

this is an observational prospective cohort study, in a cohort of up to 30 patients with idiopathic pd. the aim of this study is to demonstrate that oculometric measures are able to detect patient deterioration faster than can be detected using the currently available clinical assessment tools. in addition, to evaluate the correlation between oculometric measures and movement disorder society-sponsored revision of the unified parkinson's disease rating scale (mds-updrs) score over time ,in subjects who meet the inclusion and exclusion criteria, and who provide a signed informed consent. all patients will be assessed using mds-updrs over a period of 9 months (4 assessments, at 0, 3, 6, 9 months). during this time period, every subject who consents will undergo a neuralight session including oculometric measurements and eye-tracking recordings using a novel software-based platform and an eye- tracking system (tobii, ce-marked class b approved device) (approx. 30 minutes). the oculometric evaluation will occur during the first 3 months for every patient every 2 weeks (+3 days), and then after 6 months and 9 months from enrollment (+3 days), (9 tests in total). all assessments will be performed during a clinic visit unless authorized to be conducted remotely. during the study, the sponsor will be blinded to the private details of the subjects.

Eligibility criteria:
inclusion criteria: * men and women with idiopathic pd (hoehn \& yahr scale 1-3) * age between 18 and 85 years old * normal or corrected vision * ability to follow instructions * willing and able to sign an informed consent form exclusion criteria: * inability to sit for 30 minutes on a chair in a calm manner * personal or 1st degree relative history of epilepsy * additional neurological diseases * drug or alcohol abuse (except for using medical cannabis during 24 hours prior nl examination date) * pregnancy or a potential pregnancy (self-declaration)