Kornimate/medical-research-clean huggingface dataset:
in vitro maturation of human eggs

Conditions: Healthy; PCOS; PCOS (Polycystic Ovary Syndrome); Ovarian Reserve; Infertility; Infertility Female; Infertility of Tubal Origin; Infertility Poly Cystic Ovary; AMH; In Vitro Maturation; IVM; IVF

Summary: ccrm fertility, a global pioneer in fertility treatment, research and science, is seeking participants for a new study on in vitro maturation (ivm). ivm requires less hormones to stimulate the ovaries than ivf, making it more affordable than ivf with fewer side effects. participants that qualify for the study will receive a free cycle of ivm treatment at ccrm fertility and including a new patient consultation, fertility testing, preimplantation genetic testing for aneuploidies (pgt-a), anesthesia and some medication

patients will undergo a complete ivf workup to qualify for study. once passing their baseline appointment patients will undergo a three day low dose stimulation followed by egg retrieval 18-22 hours post last medication dosage. immature oocytes will be retrieved from the ovaries via ultrasound guided tv aspiration and matured overnight in the laboratory. mature oocytes will be fertilized via icsi the following day and cultured to the blastocyst stage. biopsy of the first 14 blastocysts are included with this package, patients have the option biopsy additional embryos if available. biopsies will be sent for pgta testing. this study also includes preparation for and the first frozen embryo transfer. some fet medication is included as well as testing through the first pregnancy test.

Eligibility criteria:
inclusion criteria: * infertile women diagnosed with pcos or polycystic ovaries, or infertile women with good ovarian reserve * antral follicle count (afc) greater than 24 * amh greater than 3.5 ng/ml * body mass index less than 35 * accept to have embryos biopsied for pgt * intend to perform embryo transfer within 4 months after completing the ivm cycle * paternal (or donor) age \&lt;45, ejaculated sperm collection only (partner frozen and donor sperm acceptable), sperm morphology (strict criteria) \&gt;1%, motility \&gt; 20% and sperm count \&gt; 10 million per ml (so samples can be prepared through standard procedure) exclusion criteria: * more than 2 failed ivf cycles

Keywords: ivm infertility pcos ivf
lidocaine spray compared with submucosal injection during leep: a randomized controlled trial

Conditions: Uterine Cervical Dysplasia

Summary: loop electrosurgical excision procedure (leep) is a widely used minor surgical procedure for diagnosis and treatment of cervical intraepithelial neoplasia. during the procedure, several methods have been proposed to reducing pain including submucosal block, paracervical block, and oral analgesics. submucosal (underneath the lining of the cervix) injection of lidocaine appeared to be the most common methods used. however, from the investigators experience, there is significant pain associated with the injection itself. lidocaine spray is an effective measure for pain control during minor gastrointestinal and otolaryngological procedures. it is simple without pain related to application. an objective of this study is to examine effectiveness of lidocaine spray versus lidocaine submucosal injection by comparing pain scores at various stages of the leep procedure.


Eligibility criteria:
inclusion criteria: * any degrees of cervical dysplasia detected from cervical cytology or histology * need to have loop electrosurgical excision procedure (leep) for diagnosis and/or treatment exclusion criteria: * allergy to lidocaine * pregnancy * previous history of cervical operation including conization, leep, laser therapy and cryotherapy * cardiac arrhythmia * neural disease with impaired sensation * lower urinary tract cancer * coagulation defect * drug dependence * lower genital tract infection * obvious invasive disease of the cervix
the benefit of adding fish oil to the nutrition of critically ill patients

Conditions: Sepsis Syndrome

Summary: we study whether an increased proportion of omega-3-fatty acids (contained in fish oil) in the nutrition of critically ill patients reduces systemic inflammation.


Eligibility criteria:
inclusion criteria: * indication for parenteral nutrition exclusion criteria: * hypertriglyceridemia * coagulation disorder * decompensated liver cirrhosis or acute liver failure
screening muscle strength in arthroscopic surgery of the hip

Conditions: Femoroacetabular Impingement

Summary: hypothesis we hypothesise that hip muscle strength can predict the outcome of hip arthroscopy. a relationship between strength and outcome can improve the success of the procedure and avoid unnecessary and potentially harmful surgery. objectives the primary objective is to evaluate the relationship between hip muscle strength and outcomes of hip arthroscopy. the secondary objective is to determine a 'threshold strength' above which the operation becomes successful. if this relationship is established, it would launching a randomised control trial with targeted physiotherapy as the intervention. background hip arthroscopy is key-hole surgery to the hip joint which is performed for femoroacetabular impingement; a condition which describes a shape mismatch between the ball-and-socket hip joint. the number of procedures is increasing, however, studies have shown success in only half of patients undergoing the procedure. several factors have been linked with outcomes; however, the influence of muscle strength has never been investigated. we performed a systematic review of this topic, revealing that muscles around affected hips are significantly weaker. we also developed a standardised protocol for the measurement of muscle strength. plan patients awaiting hip arthroscopy will undergo muscle strength testing pre- and post-operatively. there will be no deviation of treatment from their nhs care. validated outcome measure questionnaires will be completed at five months post-operatively. magnetic resonance imaging and electromyography tests will be performed on a subset of patients post-operatively.


Eligibility criteria:
inclusion criteria: * patients aged 18-45 years with evidence of fai on mri scan (the standard method of imaging of the condition in the nhs) * competent to consent to study participation exclusion criteria: * established osteoarthritis with evidence of osteophytes (tonnis grade \>2) * patient with hip dysplasia (centre-edge-angle \<20 degrees) * patients with full thickness cartilage (chondral) lesions * previous diagnosis of mental health disorder * failure to comply with addenbrooke's hospital post-operative rehabilitation exercises tailored to hip arthroscopy
aim to improve asthma: airflow improvements during meal-prep

Conditions: Asthma in Children; Pollution; Exposure

Summary: the investigators propose a pilot trial of kitchen ventilation in the homes of children using a youth engaged research strategy.

in this trial of children ages 6-12, children and their households will receive an intensive home kitchen ventilation intervention after one week of baseline data collection. the intervention includes education regarding improving ventilation in their homes during cooking and replacement of their range hood if it has inadequate flow or an intolerable noise level. during baseline data collection periods the households will be encouraged to continue their regular cooking patterns. the investigators will measure home particulate matter \<2.5 microns (pm2.5) and nitrogen dioxide (no2) levels for one week at baseline, and a final week after all remaining families receive the cooking ventilation intervention, to assess for changes within each household. the investigators will also examine changes in airways inflammation (as measured by the exhaled fraction of nitric oxide, feno), lung function (as measured by spirometry), and reported symptoms after the baseline and intervention period. members of the research team have successfully conducted youth participatory action research in the low-income, high asthma prevalence community of richmond, california (ca) as well as extensive youth participatory action research on other environmental health concerns in the low income city of salinas, ca; using a similar model, the investigators aim to teach research methods to a new group of richmond youth.

Eligibility criteria:
inclusion criteria: * household has a gas stove * household has a range hood that vents to the outdoors * household in richmond or san pablo exclusion criteria: * child has other significant medical illnesses (e.g. prematurity, diabetes) * living with a smoker who smokes indoors * family knows they will not have stable housing for the period of the study * parent is not fluent in english.

Keywords: asthma pediatric indoor air pollution particulate matter nitrogen dioxide cooking ventilation
influence of antiviral therapy on bone mineral density and metabolism in patients with chronic hepatitis c

Conditions: Hepatitis C, Chronic; Liver Diseases; Virus Diseases

Summary: one single study has suggested that bone mineral density (bmd) is reduced in patients with non-cirrhotic chronic viral hepatitis c. antiviral combination therapy with standard interferon and ribavirin may further decrease bmd. the aim of this study is to systematically investigate the effect of chronic hepatitis c genotype 1 infection alone and current standard therapy with peginterferon alfa-2a/ribavirin on bmd and bone metabolism.


Eligibility criteria:
inclusion criteria: * proven chronic hepatitis c * aged between 18 and 65 * male patients exclusion criteria: * high grade liver fibrosis (grade 3 - 4) * renal disease * hyperparathyroidism * hypogonadism * malignant disease * use of any other drug known to effect bone mineral metabolism * use of alcohol * organ transplant * any form of thyroid disease * any medical condition known to be associated with bone loss

Keywords: hcv hepatitis c virus chc chronic hepatitis c interferon ribavirin dexa bmd bone mineral density osteoporosis osteopenia osteodystrophy osteodensitometry bone density hepatitis, viral, human anti-infective agents peginterferon alfa-2a
correlation between angle closure glaucoma data and lens zonule status

Conditions: Primary Angle Closure Glaucoma

Summary: the goal of this observational study is to discuss the correlation between primary angle-closure glaucoma and the state of the suspended ligament of the lens and the pathogenesis of pacg by measuring the biological data of primary angle-closure glaucoma and observing its anatomical changes.

patients clinically diagnosed with primary angle-closure glaucoma (pacg) and normal control patients from december 2020 to january 2022 were enrolled in this study.

Eligibility criteria:
inclusion criteria: * the depth of the anterior chamber is normal, and the whole corner of the chamber is open; * the cup-to-plate ratio is less than 0.5; * no family history of glaucoma. exclusion criteria: * previous history of trauma or internal eye surgery in both eyes or one eye; * used "pilocarpine", "atropine" and other drugs to change the size of the pupil and the shape of the chamber angle within 1 week; * combined with other eye diseases affecting the angle and suspension ligament, such as uveitis, ciliary cyst, high myopia, retinal diseases, etc.; * can not cooperate with ubm and angle scopy; * refuse to participate in this researcher.

Keywords: primary angle closure glaucoma ubm lens zonule
vigab-biostat: neuronal injury panel substudy

Conditions: Status Epilepticus; Cardiac Arrest With Successful Resuscitation

Summary: the purpose of this substudy is to collect and analyze control data to characterize the degree of neuronal injury in pase patients who have not received vigabatrin to later compare with patients who received this therapy and expand data on the utility of the neuronal injury panel for neuroprognostication. data from this cohort will be compared with the data generated by the treatment cohort in the main vigab-stat study.

post anoxic status epilepticus (pase) is the development of intractable seizures in the post-cardiac arrest period once return of spontaneous circulation (rosc) has been achieved. historically, this condition has resulted in nearly 100% mortality, and the subset of patients diagnosed with pase has been excluded from previous therapeutic trials in status epilepticus. the administration of vigabatrin, a gaba-ergic medication that blocks gaba catabolism, is being investigated as an adjunctive therapy to improve neurologic outcomes in this patient population through the vigab-stat program at the university of florida. neuroprognostication in cardiac arrest patients remains imprecise. outcomes following cardiac arrest depend on a multitude of factors, from details of cardiac arrest (e.g., downtime and rhythm on arrest) to other factors that influence secondary brain injury-all of which are hard to ascertain from objective clinical and laboratory data. neuronal and astroglial protein assays have been investigated in this patient population as a novel method of quantifying the degree of neuronal injury and may serve as an objective informant of ongoing secondary brain injury, thus being a helpful neuroprognostic tool. this assay can also demonstrate objectively if a neuroprotectant therapy mitigates secondary brain injury and decreases the overall hypoxic-brain injury burden. however, normative data on these assays on post-cardiac arrest patients suffering pase are lacking.

Eligibility criteria:
inclusion criteria: * to be included in the study, subjects must be 18 - 80 years of age * non-traumatic cardiac arrest (regardless of non-perfusing rhythm, etiology, or location of arrest) in whom the decision to treat unequivocal electrographic se (as defined by the american clinical neurophysiology society: having generalized spike/sharp-wave discharges ≥ 3hz or any evolving pattern reaching \> 4hz, lasting ≥ 10 minutes, or comprising \> 50% of any hour of recording) has been made, * requiring anesthetic infusion for any reason, * have reliable arterial access for frequent blood sampling * be enrolled and have the first specimen drawn within 48 hours of pase onset. exclusion criteria: * subjects must not have a prior history of generalized epilepsy * be pregnant or * have pase onset preceding initiation of eeg monitoring.
study of the health information needs of brain cancer patients

Conditions: Brain Tumor

Summary: the purpose of this research is to explore the factors involved in brain cancer health care literacy needs.

a mere subset of the reasons behind unmet health care literacy needs include the health care systems' increasing complexity, increased time constraints, profound treatment decision making requirements, decreased financial resources, fracturing social networks and diversifying educational and cultural needs. this project will use focus groups to explore the factors involved in brain cancer health care literacy from the perspectives of patients and those involved in their care. hypothesis generated from this project will be directly applied toward future projects. the overarching goals are improved access and adequacy of health care literacy information through the eventual development of validated, useful, reliable health care literacy information tools for brain cancer patients and those involved in their care.

Eligibility criteria:
inclusion criteria: brain tumor patients: * 18 to 89 years of age * have or have had any type of brain tumor * ability to communicate in english * willingness to participate in a 30-60 minute focus group health care providers: * 18 to 89 years of age * be a health care provider who cares for any type of brain tumor * ability to communicate in english * willingness to participate in a 30-60 minute focus group exclusion criteria: * none

Keywords: brain tumor brain neoplasm
a study to compare the pharmacokinetics and the safety between a fixed-dose combination administration of "br3005" and co-administration of "br3005-1" and "br3005-2" under fasting conditions in healthy adult volunteers

Conditions: Type 2 Diabetes Mellitus

Summary: the objective of this clinical study is to compare the pharmacokinetics and the safety between a fixed-dose combination administration of "br3005" and co-administration of "br3005-1" and "br3005-2" under fasting conditions in healthy adult volunteers


Eligibility criteria:
inclusion criteria: * those who have body mass index (bmi) within the range of 18.0 to 30.0kg/m² at screening visit * in case of a male subject, those who weigh 50 kg or more * in case of a female subject, those who weigh 45 kg or more * those who sign written consent spontaneously after listening to and understanding sufficient explanation of the purpose and contents of this clinical trial, characteristics of the investigational products, expected adverse events, etc. exclusion criteria: * those who have taken drugs that induce and inhibit metabolizing enzymes such as barbiturate within 30 days prior to the first day of administration or have taken drugs concerned about affecting this clinical trial within 10 days prior to the first day of administration. (however, participation is possible considering pharmacokinetics and pharmacodynamics such as interaction of investigational products, half-life of concomitant drugs, etc.) * those who have participated in other clinical trials(including bioequivalence tests) and administered their investigational products within 6 months prior to the first administration date.(however, the termination for participation in other clinical trials are based on the last administration date of their investigational products) * those who have a medical history of gastrointestinal surgery or gastrointestinal diseases that may affect the absorption of drugs. (except for simple appendectomy, hernia surgery) * in the case of a female subject, those suspected pregnancy, pregnant woman, lactating woman.
blood flow restriction training following glenoid labral repair

Conditions: Glenoid Labrum Tear

Summary: the objective of this study is to evaluate the effects of bfr training on patient reported outcome measures and shoulder muscle girth in patients following glenoid labral repair. the investigators hypothesize that participants receiving bfr with rehabilitation will have greater improvements in patient reported outcome measures and shoulder muscle girth than participants who are treated without bfr.

patients between the ages of 18 and 55 who had a superior labrum anterior to posterior (slap) repair, anterior labral repair, anterior capsulorrhaphy, or posterior labral repair will be screened for participation in this study. participants will be randomized in a 1:1 ratio to receive standard physical therapy with blood flow restriction training or without blood flow restriction. participants will receive standard of care rehabilitation for labral repair regardless of group assignment. the length of each physical therapy session will be approximately one hour. the bfr and control group will perform leg press and leg extension exercises prior to shoulder strengthening. the resistance for both groups will be set as 30% of one repetition maximum (1-rm). the goal will be for the participants to perform 4 sets of repetitions sequenced 30, 15, 15, 15 of each exercise, if this is not obtainable then the number of set/repetitions will be decreased. the lower extremity strengthening exercises for this study will be performed by all participants beginning at the first physical therapy visit post-surgery. these exercises will be performed at each physical therapy session for 6 consecutive weeks (approximately 2-3 sessions/week). standard rehabilitation will continue at the conclusion of the 6-week intervention for all participants.

Eligibility criteria:
inclusion criteria: * superior labrum anterior to posterior (slap) repair, anterior labral repair, anterior capsulorrhaphy, or posterior labral repair * willing to complete their post-operative rehabilitation at andrews institute physical therapy exclusion criteria: * patients with prior procedures or significant injuries to the same shoulder will be excluded * patients with arthroscopic debridement of labral tears alone * patients with concomitant rotator cuff repair surgery * patients with workers' compensation or automobile insurance claim will be excluded. * patients who have a medical history involving any of the following medical conditions will be excluded - uncontrolled hypertension, diabetes, autoimmune disorders, rheumatoid or psoriatic arthritis, multiple sclerosis, peripheral vascular disease, peripheral neuropathy, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, blood disorders, disorders requiring immunosuppression, cancer, an ongoing infectious disease, use of steroids, or significant cardiovascular, renal, hepatic or pulmonary disease
neurological changes with a memory self-efficacy training protocol

Conditions: Mild Cognitive Impairment

Summary: confidence in one's ability to accomplish a task, more formally known as self-efficacy, is an important psychological variable that can influence how the investigators perform on various tasks. previous studies have shown that self-efficacy is a modifiable trait that can be improved and bolstered with training and practice. more importantly for this study, memory self-efficacy has been shown to be modifiable for older adults, consequently improving their performance on memory tasks. while there is evidence to support the importance of memory self-efficacy for successful memory performance in older adults, the underlying neurological changes that accompany these performance changes have not been explored. the goal of this study is to examine the changes in brain activity before and after a memory self-efficacy training program to better understand the mechanisms of both memory and self-efficacy.


Eligibility criteria:
inclusion criteria: 1. subjective memory complaints within past 5 years 2. objective memory impairment below age norms on standardized cognitive testing 3. score below 25 on montreal cognitive assessment 4. scores 1.5 standard deviations below age norms on memory testing 5. unimpaired performance in activities of daily living 6. intact general cognition 7. fluently read, write and speak english 8. right handed exclusion criteria: 1. co-morbidity that would impact cognition (depression, anxiety, stroke) 2. prior diagnosis of dementia of any type 3. use of prescription or recreational drug use that would impact cognition (excluding hormone replacement therapy) 4. uncorrected visual or auditory deficits/impairments 5. current participation in alternate study

Keywords: memory older adults randomized control trial mri memory education