Kornimate/medical-research-clean huggingface dataset:
serum maresin-1 predicts the severity of severe acute pancreatitis

Conditions: Pancreatitis, Acute

Summary: this is a retrospective study about serum maresin-1 level in different severe acute pancreatitis patients. the investigators want to study the correlation between the level of serum maresin-1 and the severity of sap, of course the clinical outcomes. the investigators want to find some biomarkers and strategy target drugs of severe acute pancreatitis.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of severe acute pancreatitis * biliary pancreatitis * 7 days of the onset exclusion criteria: * surgical patients * serious diseases and infection * alcoholic pancreatitis * hypertriglyceridemia pancreatitis * disorder of glucolipide metabolism：diabetes mellitus, hypertriglyceridemia, bmi\>30

Keywords: maresin-1 sap ipn mods mortality
shake it up: lipidomics of lipoproteins and diet

Conditions: Overweight

Summary: the purpose of this research is to understand how dietary fat is related to cardiovascular disease (cvd). this study tests the effect of different dietary fats on the level of fat in the blood and the particles that transport fat in the blood. the researchers want to know if these particles change after eating meals made with different fats.

the overall objective of this work is to discover how the lipidomic composition of postprandial lipoproteins responds to dietary fats of differing fatty acid composition by comparing meals rich in saturated fatty acid (sfa) (from dairy cream) versus polyunsaturated fatty acids (pufa) (from soybean oil). the information derived from these studies will provide mechanistic insight into postprandial lipid metabolism and will support efforts to identify optimal dietary oil intakes for people.

Eligibility criteria:
inclusion criteria: * normal to overweight (bmi 18.0-29.9 kg/m\^2 * willing to comply with the demands of the experimental protocol exclusion criteria: * inability to provide consent * have fasting blood glucose \ 126 mg/dl * have fasting blood cholesterol \>300 mg/dl * have fasting blood triglyceride \ 300 mg/dl * have uncontrolled hypertension (blood pressure \>140/90 mm hg) * take prescription medications for blood sugar or lipid management or anti-inflammatory steroids (e.g. cortisone) * over the counter use of supplements (fish oil, flax, plant sterol or sterol esters) and unwilling to discontinue use for 6 weeks prior to study initiation * have a history of an eating disorder, unusual dietary pattern (extreme nutrient or food group restriction; erratic meals due to shift work, etc.) * have established cardiovascular, pulmonary, and/or a metabolic disease such as diabetes * have cancer * use tobacco products or nicotine in any form including snuff, pills, and patches, or e-cigarettes/vaping in the past 6 weeks * have alcohol, anabolic steroids, or other substance abuse issues * consume more than 3 alcoholic drinks/week * are lactose intolerant or have an allergy to dairy foods

Keywords: normal weight
the spinus ii study: spinal fusion for multilevel spect/ct positive lumbar degeneration

Conditions: Degenerative Disc Disease; Back Pain Lower Back Chronic; Facet Joint Arthropathy; Facet Syndrome of Lumbar Spine

Summary: the aim of the present study is to find out whether fusion of multilevel spect/ct positive lumbar degeneration leads to a significant improvement of pain and disability.

chronic back pain (cbp) is a very common clinical problem. it is dominantly caused by degenerative changes, while specific causes such as tumor, trauma or inflammatory conditions are relatively rare. back pain may be a concomitant symptom of lumbar disc herniation or spinal canal stenosis and is a typical symptom of spondylolisthesis. magnetic resonance imaging (mri) plays a key role in the diagnosis, showing in detail the soft structures, vertebral bodies (modic changes, mc) or signs of facet arthropathy. on the other hand, it also proves a number of clinically silent findings. degenerative disc disease (ddd) or facet osteoarthritis are most often considered to be a pain generator. the problem, however, is that both entities are very common in the general population without a painful correlate, and there is still controversy in the literature about their role in the genesis of cbp. radionuclide bone scintigraphy with single photon emission computed tomography (spect) provides functional imaging and is used to detect microcalcification due to increased osteoblastic activity. in the absence of other pathology the foci of increased osteoblastic activity reflex areas of mechanical stress and degenerative change in the skeleton. there is growing evidence about the relationship between ddd, facet arthropathy, and spect positivity. although these findings have been recently confirmed by surgical studies, the evidence about the effect of surgical treatment of spect positive lumbar degeneration is still weak due to the small number of operated patients. the aim of the present study is to define a possible correlation between degenerative changes of the lumbar spine and positivity on spect/ct imaging. patients with multilevel spect+ ddd or facet arthropathy will undergo spinal fusion of the involved segments. postoperative improvement will be measured by odi (oswestry disability index) and pain vas (visual analogue scale) in 6 and 24 months follow-up period.

Eligibility criteria:
inclusion criteria: * lower back pain (in extension +/- pain in buttocks, groin, thigh) without radicular pain * symptoms \> 6 months after the failure of conservative management in the primary care setting * mri signs of degenerative disc disease or facet arthropathy * two- or more levels of positivity on lumbar spect/ct exclusion criteria: * other spinal pathology (tumors, congenital defects, spondylolysis, or spondylolisthesis) * intolerance of spect examination * pregnancy
plasma exchange and continuous hemodiafiltration in treatment of wilson's disease-related liver failure

Conditions: Wilson Disease; Liver Failure

Summary: this study is to investigate the clinical efficacy of artificial liver support system using combination of plasma exchange and continuous hemodiafiltration in treatment of wilson's disease - related liver failure. 30 patients will receive treatment of plasma exchange and continuous hemodiafiltration and internal medicine. 30 patients will receive treatment of internal medicine.

wilson's disease (wd) is an inherited disorder in which defective biliary excretion of copper leads to its accumulation, particularly in liver and brain. presenting symptoms of liver disease can be highly variable, ranging from asymptomatic, with only biochemical abnormalities, to overt cirrhosis with all its complications. acute liver failure (alf) presentation is the most dramatic and may arise with catastrophic suddenness. it is considered rare, constituting only 3% of alf cases in the pediatric alf series in usa and associated with a high mortality reaching 95%. patients with acute liver failure due to wd require liver transplantation, which is lifesaving. kido j et al reported clinical outcomes of patients with liver failure were improved by artificial liver support system using combination of plasma exchange and continuous hemodiafiltration. so the investigators design this protocol: 30 patients will receive treatment of plasma exchange and continuous hemodiafiltration and internal medicine, 30 patients will receive treatment of internal medicine.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of wilson disease: serum ceruloplasmin \ 40μg, kayser-fleischer ring present; 2. do not receive drugs to promote the excretion of copper ever before; 3. serum total bilirubin \> 10 times upper limit of normal, prothrombin time activity \ 1.5. exclusion criteria: 1. other active liver diseases; 2. hepatocellular carcinoma or other malignancy; 3. pregnancy or lactation; 4. human immunodeficiency virus infection or congenital immune deficiency diseases; 5. severe diabetes, autoimmune diseases; 6. other important organ dysfunctions.

Keywords: wilson disease liver failure plasma exchange continuous hemodiafiltration
antibiotic prescription for children with acute upper respiratory tract infections in assiut district

Conditions: Antibiotic Side Effect

Summary: antibiotics are one of the most commonly prescribed drugs in pediatric care all over the world. over prescription of antibiotics is a major public health problem and the most important factor in the emergence of antibiotic resistance. it is important to study physicians' antibiotic prescribing behavior to understand its determinant and for further planning of appropriate interventions to optimize antibiotic prescription.

antibiotics are one of the most commonly prescribed drugs in pediatric care all over the world. over prescription of antibiotics is a major public health problem and the most important factor in the emergence of antibiotic resistance. in egypt, a recent study conducted in el-minya governorate to investigate antibiotic use in phc centres and in governmental hospitals, revealed that physician prescriptions of antibiotics for aris were extremely high as 82% of pediatric visits for aris resulted in an antibiotic prescription. most of these infections are caused by viruses and do not require antibiotic treatment. numerous interventions to improve antibiotic prescribing practices have been reported from various countries with varying results. no single intervention appears to have superior efficacy, but combinations of interventions are typically more effective, and strategies that target health care professionals and/or patients (or parents of young children) have achieved success at reducing antibiotic prescriptions for aris. despite the emergence of antibiotic resistance and international efforts to reduce antibiotic use, prescription still high and inappropriate. children are a vulnerable group and inappropriate antibiotic prescription may affect their health and may contribute to development of many diseases as allergies beside emergence of antibiotic resistance. also, most of acute respiratory infections in children are viral infections and they receive antibiotic for it. so,, it is important to study physicians' antibiotic prescribing behavior to understand its determinant and for further planning of appropriate interventions to optimize antibiotic prescription.

Eligibility criteria:
inclusion criteria: 1. physicians dealing with pediatric cases. 2. gps, pediatrics, or otolaryngology (ent) residents. exclusion criteria: 1. physician who didn't work at outpatient clinics. 2. physicians who are specialized and hold a degree.
stimulating postural control to augment rehabilitation after cerebral stroke (sparc): a pilot trial

Conditions: Stroke

Summary: people living with stroke have a high risk of falling and this risk increases as mobility improves over the first year post-stroke. despite the high number of falls, there is a lack of interventions to prevent falls after stroke. one possible solution is to alter nerve activity through delivery of a stimulus, such as electrical stimulation. the purpose of this study is to test the study plan and to find out whether enough participants will join a larger study and accept the study procedures of combining electrical stimulation with balance training.


Eligibility criteria:
inclusion criteria: * aged 18 years or greater * diagnosed with a middle cerebral artery stroke \>1 year ago * community-dwelling (i.e. not living in long-term care or other inpatient setting) * able to stand independently for 60 seconds * able to understand spoken english exclusion criteria: * any condition other than stroke that significantly affects their postural control (e.g. vestibular disorder, vision loss) * a prior lower extremity fragility fracture * a planned injection of botulinum toxin to the legs during the intervention period * peripheral nerve damage in the legs * contraindications for fes (i.e. implanted electronic device, active cancer or radiation in past six months, uncontrolled epilepsy, skin rash/wound at an electrode site, pregnancy, active deep vein thrombosis) * contraindications for tms (i.e. seizures, metal in the head) * previous participation in fes or tscs within the past 2 years (may affect blinding integrity. likely uncommon; fes is rarely used in canada post-stroke.)

Keywords: functional electrical stimulation transcutaneous spinal cord stimulation postural control
norepinephrine weaning guided by the hypotension prediction index in vasoplegic shock after cardiac surgery

Conditions: Vasoplegia; Shock; Norepinephrine; Surgery

Summary: in postoperative cardiac surgery under extracorporeal circulation, the patient may develop a vasoplegic syndrome, characterized by arterial hypotension (mean arterial pressure (map) \< 65 mmhg); a decrease in vascular resistance and a cardiac output that may be normal or increased, and increased postoperative mortality/ international recommendations recommend the prescription of noradrenaline as a first-line treatment to reduce morbidity and mortality. however, excess norepinephrine or duration of exposure is also deleterious. the acumen iq device (edwards lifesciences) allows the calculation of a predictive index of arterial hypotension episodes (predictive hypotension index, hpi). hpi could improve norepinephrine weaning by preventing episodes of arterial hypotension or detecting preload dependence, thus avoiding the transient increase in norepinephrine during hypotension. this is a single-center, prospective, open-label, randomized, controlled, 2-group, parallel, intention-to-treat study. the aim was to evaluate the superiority of a new decision algorithm, based on the hpi delivered by the acumen iq device, to reduce the duration of norepinephrine administration in post-cardiac surgery vasoplegic shock. the duration of the interventional protocol is 72 hours. to evaluate the clinical impact of the protocol, the time of the study will be 30 days. several follow-up visits will be performed (end-of-protocol day, discharge day, and at d30 of inclusion) to collect clinical, biological, and hpi monitoring data.


Eligibility criteria:
inclusion criteria: * age \> 18 years * the patient was hospitalized in the cardiothoracic-vascular and respiratory intensive care unit of amiens-picardy university hospital. * patient scheduled for on-pomp cardiac surgery \[coronary artery bypass grafting, valve replacement, ascending aorta replacement, or combined surgery (valve and bypass grafting)\]. * introduction of norepinephrine post-surgery for the treatment of vasoplegic syndrome. * on-pomp cardiac surgery in less than 48 hours. * hemodynamically stable patient with map \> 65 mmhg for more than 4 hours on noradrenaline * monitoring of map with a radial or femoral arterial catheter * social security beneficiary * signature of the consent to participate in the study by the patient, preoperatively exclusion criteria: * permanent arrhythmia (atrial fibrillation, flutter, or frequent atrial extrasystoles). * treatment with dobutamine, epinephrine, or vasopressin analog * patients with preoperative chronic end-stage renal failure require postoperative extra-renal purification. * pregnant woman * the patient is dependent on an internal or external pacemaker. * hypothermia \< 36°. * patient under mechanical circulatory assistance after cardiac surgery. * hemorrhagic shock * patient under guardianship or curators

Keywords: vasoplegia shock hypotension prediction index acumen cabg norepinephrine surgery
kinematics of obese patients perambulation

Conditions: Morbid Obesity; Surgical Management by Laparoscopic Sleeve Gastrectomy

Summary: the aim of this study is to evaluate the consequences of sleeve gastrectomy on functional parameters of patients perambulation.

laparoscopic sleeve gastrectomy is the standard surgical procedure for the treatment of obese patients. even the surgery is well described, there is no available study about its influence on the functional parameters of patients perambulation.

Eligibility criteria:
inclusion criteria: * bmi between 40 and 60 kg/m2 or bmi \> 35 kg/m2 with at least one comorbidity * no weight loss * between 18 and 65 years old * history of obesity \> 5 ans exclusion criteria: * history of bariatric surgery * major cardiac insufficiency * pregnancy or breastfeeding * no social welfare

Keywords: obesity surgery
dexmedetomidine and ketamine as an adjuvant in external oblique intercostal plane block for post thoracotomy pain

Conditions: Dexmedetomidine; Ketamine; External Oblique Intercostal Plane Block; Post Thoracotomy Pain

Summary: the aim of this study is to compare the role of dexmedetomidine and ketamine as an adjuvant in external oblique intercostal plane block for post thoracotomy pain.

postsurgical pain in patients who have undergone open thoracotomy for lung cancer or other lung surgeries is known to be very severe. as a result, this pain alters spontaneous breathing, delays postoperative recovery, and persists as chronic post-thoracotomy pain syndrome . post-thoracotomy pain syndrome is relatively common and is seen in approximately 50% of patients after thoracotomy. it is a chronic condition, and about 30% of patients might still experience pain 4 to 5 years after surgery.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * both sexes. * american society of anesthesiology (asa) physical status i-iii. * scheduled for open thoracotomy. exclusion criteria: * patients with neurological or intellectual disability. * infection at the injection site. * opioid addiction. * allergic reaction to local anesthetics. * coagulation abnormalities. * drug abuse. * pregnancy. * severe liver and/or renal failure. * uncontrolled hypertension. * severe cardiovascular problems. * diabetes mellitus.
zika and microcephaly: case-control study

Conditions: Microcephaly

Summary: it is suspected that zika virus infection during pregnancy is associated with microcephaly. the objective of this study is to investigate the occurrence of rash accompanied by three or more dengue-like signs and symptoms during pregnancy is related to the microcephaly using the case-control design.

the investigators will carry out a case-control study among mothers who delivered their babies at nossa senhora de lourdes maternity hospital located in aracaju, state of sergipe, brazil from september 1, 2015 through january 5, 2016. data sources for the phase i of the study will consist of medical records review and a standard questionnaire applied by telephone to collect information about demographic features, clinical signs and symptoms, and the duration and severity of the illness. phase ii will include dengue, chikungunya and dengue serologic test results as secondary outcome, if available. the objective of this study is to investigate the occurrence of rash accompanied by three or more dengue-like signs and symptoms during pregnancy is related to the microcephaly using the case-control design

Eligibility criteria:
inclusion criteria: * delivered a baby at nossa senhora de lourdes maternity from september 1, 2015 through january 5, 2016. exclusion criteria: * syphilis during pregnancy, toxoplasmosis during pregnancy, consanguinity, other genetics disorder, alcohol or abuse drug consumption during pregnancy.

Keywords: microcephaly zika virus case-control study
effects of slump stretching vs lumbar mobilization with exercises in relieving non-radiculating low back pain

Conditions: Low Back Pain

Summary: this study will be conducted to determine the effects of slump stretching vs lumbar mobilization with exercises in relieving non-radiculating low back pain. there will be two groups; group i will receive slump stretching along with standardized exercises and group ii will receive lumbar mobilizations along with standardized exercises.

physical therapist commonly examines and treats patients with low back pain. for this purpose, they utilize a wide range of interventions for the management of low back pain. the rhythmical movement is thought to modulate pain and muscle spasm by stimulating receptors within the mobilized structures while, in recent years, neurodynamic test procedures, have also been used as interventions to potentially resolve abnormal physiology within the nervous system. so for this purpose not only the present study can provide an additional evidence to the literature but also can can also demonstrates a structured physiotherapy plan for treating the non-radiculating low back pain

Eligibility criteria:
inclusion criteria: individuals with non-radiculating low back pain test: i. slump test=positive ii. straight leg raise=negative exclusion criteria: individuals with radiculating low back pain,history of spinal surgery, disc herniation,pregnant women, major diseases (e.g. stroke)

Keywords: effects slump stretching lumbar mobilization non radiculating low back pain exercises quality of life modified oswestry low back pain disability numeric pain rating scale fear avoidance beliefs
repetitive transcranial magnetic stimulation as an analgesic treatment in endometriosis chronic pain : feasibility

Conditions: Deep Endometriosis; Chronic Pelvic Pain

Summary: endometriosis is associated with different types of pain (acute, chronic, excess nociception, neuropathic) generated by different mechanisms in the nervous system. the rtms could provide significant analgesia for refractory endometriosis pain. the aim of the study is to evaluate the feasibility of transcranial magnetic stimulation (rtms) for analgesia on chronic refractory endometriosis pain.

the first step consists of the inclusion of 12 patients followed by the filling by each patient of the redcap software of five simple numerical scales for 4 weeks . realization of a brain and medullary mri to allow neuronavigation. realization of 5 sessions of rtms in 5 days during the first week then evaluation (physical examination, questionnaires) in consultation on post-stimulation. then followed for 28 days in total through self-assessment of pain that will be filled daily on redcap and last consultation on d28 for further evaluation

Eligibility criteria:
inclusion criteria: * premenopausal (presence of at least one of the two ovaries and absence of clinical signs of menopause), * not pregnant or breastfeeding; * at least one painful symptoms related to the existence of endometriosis (dyspareunia, dysmenorrhea, pain with defecation or urination, neuropathic pain); * average vas\> 4/10, at least 4 days out of 7 for at least 3 months; * hormonal treatment failure continued in association or not for pain control; * a level of understanding and satisfying expression in french; * monitoring possible during the duration of the study (4 weeks). * these patients should be affiliated to the french social security and should have signed a written consent after receiving clear information. exclusion criteria: * prior treatment with rtms, * industrial accident or notion of litigation * cons-indication for rtms (cortical lesion within 2cm of the motor cortex, ect treatment during previous month, epilepsy and / or a history of epilepsy, history of head trauma, intracranial hypertension; * metal clip; pacemaker, * pregnant or breastfeeding women; * pain lasting less than 3 months; * another pain more severe than that associated with endometriosis; * lack of filling of the computerized questionnaires on redcap; * incapable of understanding about informed consent, * patient under guardianship.

Keywords: endometriosis magnetic transcranial stimulation chronic pain analgesic