Kornimate/medical-research-clean huggingface dataset:
neonatal outcomes in twin pregnancies

Conditions: Twin Pregnancy; Neonate

Summary: multiple pregnancies are associated with increased maternal and fetal risks compared to singleton pregnancies. additionally, the cesarean section rate is quite high in multiple pregnancies. this study aimed to evaluate maternal and fetal characteristics and factors affecting fetal outcomes in twin pregnancies delivered by cesarean section.

while the frequency of multiple pregnancies varies significantly among societies and individuals, especially in middle and high-income countries, the rate of multiple pregnancies has shown a significant rise worldwide in recent years, with the frequent use of assisted reproductive techniques, which has increased due to an increase in maternal age and a decrease in fertility. as a result, multiple pregnancies constitute approximately 2-4% of all births. multiple pregnancies are known to be associated with increased maternal and fetal risks compared to singleton pregnancies. while maternal mortality associated with a twin pregnancy is 2.5 times higher than in singleton pregnancy, adverse neonatal outcomes such as perinatal mortality, fetal growth restriction, and low birth weight are two to three times higher in twins than in singleton newborns. moreover, neonatal near-miss, which refers to cases that almost resulted in death, is associated with multiple pregnancies. for all these reasons, the planned cesarean section has been advocated over planned vaginal delivery to reduce the risk of adverse neonatal outcomes (especially for the second-born twin). however, cesarean delivery is known to be associated with a higher risk of maternal morbidity and poor neonatal outcomes. the vast majority of these risks are related to maternal hypotension, prolonged uterine-incision-to-delivery time, and general anesthesia. from this perspective, we aimed to evaluate maternal and fetal characteristics and factors affecting fetal outcomes in twin pregnancies delivered by cesarean section.

Eligibility criteria:
inclusion criteria: * twin pregnancies * parturients delivered by cesarean section exclusion criteria: * the triplets or more multiple pregnancies * twins delivered through the vaginal route were excluded from the study.

Keywords: general anesthesia neonate obstetric anesthesia pregnancy outcomes spinal anesthesia twins twin pregnancy
comparing various treatments for achieving and maintaining remission of depression

Conditions: Depression

Summary: this study will evaluate the effectiveness of five combinations of drug therapy and psychotherapy in maintaining remission of depression symptoms in people with recurrent major depression.

depression is a serious illness that can interfere with a person's ability to work, study, sleep, eat, and enjoy activities that once were pleasurable. it is characterized by several symptoms, such as the following: persistent sad, anxious, or "empty" mood; feelings of hopelessness or pessimism; and feelings of guilt, worthlessness, or helplessness. if left untreated, depression symptoms can last for years, and may worsen as time goes on. even with treatment, however, it is possible for depression to recur. remission is a main goal in the treatment of depression and it may be accomplished through various strategies. this study will evaluate the effectiveness of five combinations of treatments, including medication therapy and psychotherapy, in maintaining remission of depression symptoms. all participants in this study will first be treated with imipramine for 7 to 11 months. once remission of depression symptoms has been achieved and maintained for 20 weeks, participants will be randomly assigned to one of the following five maintenance treatments for 36 months: psychotherapy plus imipramine; psychotherapy plus placebo; psychotherapy alone; medication clinic treatment plus imipramine; or medication clinic treatment plus placebo. assessments will be made at weeks 12 and 20 and months 7, 11, and 36, and will include the time it takes for depression symptoms to recur, as well as scores on depression and mania severity scales.

Eligibility criteria:
inclusion criteria: * diagnosis of recurrent major depression exclusion criteria: * unstable medical illness * any other simultaneous psychiatric or medical illness of greater concern than depression (index episode of depression is not primary)

Keywords: major depression
study to evaluate performance of the organ recovery systems lifeport® liver transporter system, a machine perfusion system, for liver transplant

Conditions: Liver Transplantation

Summary: comparison of hypothermic machine perfusion of livers to standard of care (static cold storage).

prospective, randomized, multi-center study to show safe and effective use of whole liver preservation via hypothermic machine perfusion (hmp) as compared to livers preserved by static cold storage.

Eligibility criteria:
inclusion criteria: * ≥18 years of age * active on the united network for organ sharing (unos) waiting list for liver transplantation * de novo liver transplant recipient * written informed consent required exclusion criteria: * subject is a multi-organ transplant recipient * subject is antibodies blood group (abo) liver incompatible * subject has severe systemic infection * subject is human immunodeficiency virus (hiv) positive * subject has acute/fulminant liver failure * subject is pregnant
a study to learn about lorlatinib in patients with non-small cell lung cancer (nsclc) which has spread out.

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: the purpose of this study is to learn about lorlatinib for the possible treatment of lung cancer which could not be controlled. this study is seeking participants who: * have lung cancer that could not be controlled. * have a type of gene called a ros proto-oncogene 1. a gene is a part of your dna that has instructions for making things your body needs to work. * have received at least 1 treatment before. all participants in this study had received lorlatinib. lorlatinib is a tablet that is taken by mouth at home. they continued to take lorlatinib until their cancer was no longer responding. the study will look at the experiences of people receiving the study medicine. this will help to see if the study medicine is safe and effective.


Eligibility criteria:
inclusion criteria: 1. patients are aged 18 years or older on index date 2. patients have confirmed diagnosis of ros1-positive nsclc 3. patients have received at least one dose of lorlatinib between 1st april, 2018, and 30th september, 2023 exclusion criteria: 1. patients participated in any clinical trials using lorlatinib during the observation period.
investigation in integrated perspective of radiculomyelopathy patients

Conditions: Cervical Myelopathy; Cervical Radiculopathy

Summary: cervical radiculopathy and myelopathy are common degenerative disorders, which can create a large amount of social and medical burden. the aims of this study are(1) to investigate the functional outcomes progression before and after surgery, (2) to evaluate the biomechanical change and compensatory patterns of patients with or without decompression surgery, and (3) to design innovation intervention for the patients with cervical myelopathy and radiculopathy.

neck pain, which is common in population recently, is causing the huge burden in the global medical service system. cervical myelopathy, that is induced by disc degeneration, is turning to be an alarming public health issue. the clinical manifestations of cervical myelopathy include neck/shoulder pain, numbness/weakness of four limbs, sensorimotor impairment, and sociopsychological dysfunction. however, most of the previous studies tend to justify patients, prognosis in a single dimension. the investigators realized that no standard protocol for management in patients with the variety of manifestation and severity of signs and symptoms.this study is purposed to integrate and analyze the finding in surgery selection, clinical manifestation, psychological consultation, compensatory patterns in the neuromusculoskeletal system, postural control, home exercise and biomechanical features. then, the investigators will develop a complementary model in assessment and prediction of prognosis, and also an applicable standard guideline in the clinical setting. to achieve the expected target, the principal investigator will play the role as the main coordinator in the team. the 3-year plan is listed as below: 1. in the first year, the patients will be recruited for projects from different co-investigators. the recruited participants will be allocated to different study group after assessment to ensure the most suitable intervention are offered to the participants. 2. in the second year, the participants' recruitment will be continuing. the effectiveness previous treatment will be assessed. the study procedure will be adjusted based on pilot results. 2. in the third year, the study finding of all co-investigators and results of the biomechanical analysis will be integrated to establish the model of prognosis prediction and clinical management guideline. this study will provide a complete clinical management guideline in cervical myelopathy, which is expected to be globally leading reference in the management of cervical myelopathy.

Eligibility criteria:
inclusion criteria: * diagnosed as cervical myelopathy or radiculopathy based on imaging results exclusion criteria: * with spondylolisthesis, rheumatoid arthritis, multiple sclerosis * with cancer/tumor * with neurological or psychological disorder * not suitable for cervical decompression surgery or physical therapy

Keywords: decompression surgery functional outcome biomechanic rehabilitation
predictive factors of a successful implant of the capsurefix mri model 5086

Conditions: Bradyarrhythmia

Summary: pacing leads are key elements of a pacing system as their proper functioning is one of the major factors affecting the long term performance of the whole system. success of a pacing lead implant can be defined considering 3 items: ease of lead implant, lead stability and lead electrical performances. these factors may be related to the physician experience (global implant experience, experience with a given lead), to the implant procedure (lead access, lead position, implant time, scopy time) to the lead (handling and mechanical characteristics) and to the patient (ischemic history). even though implant success rate is quite high with currently available leads, the weight of the different factors influencing success has never been studied systematically. the objective of the current study is then to define the predictive factors of an implant success with the capsurefix mri model 5086. this lead has been selected because it has been available for a short period, so the investigators have a limited experience of it and it has a unique design which makes it conditionally safe in an mri environment and which may be associated with specific handling characteristics.


Eligibility criteria:
inclusion criteria: * patient older than 18 * patient implanted with a fully automatic icd and remotely followed-up, * patient geographically stable and able to attend fu at investigative site * patient who signed a data release authorization form, exclusion criteria: * patient whose mental or physical capacity impedes to give an informed data release authorization, * patient already enrolled in a clinical study whose procedures may interfere with the results of the present study, * patients in new york heart association (nyha) class iv

Keywords: pacing lead implant pacemaker
study on the usage, dosing, tolerability, and effectiveness of kaletra tablet

Conditions: Human Immunodeficiency Virus

Summary: the objective of this study is to observe and collect data on the usage, dosing, tolerability, and effectiveness of kaletra (lopinavir/ritonavir) tablets in human immunodeficiency virus (hiv)-infected patients. in some patients, the study is to show the impact on tolerability of changing therapy to kaletra tablets from other regimens.

this study was designed as a non-interventional observational study. kaletra was prescribed in the usual manner in accordance with the terms of the local market authorization with regards to dose, population and indication as well as local guidelines.

Eligibility criteria:
inclusion criteria: * patients with hiv infection * patients that will be treated with kaletra tablets independent from their participation in this study exclusion criteria: * hypersensitivity against kaletra or other ingredients * severe liver insufficiency * no concommitant astemizole, terfenadine, oral midazolam, triazolam, cisapride, pimozide, amiodarone, ergotamine, dihydroergotamine, ergometrine, methylergometrine, vardenafil and st. john's wort * patients who received more than 1 protease inhibitor during their therapy history

Keywords: tablets infection non nucleoside reverse transcriptase inhibitor tolerability viral load human immunodeficiency virus effectiveness treatment-naïve
language during inhalational induction

Conditions: Emergence Delirium; Anesthesia; Adverse Effect

Summary: the aim of this study is to compare the impact of common (standard of care) language vs positive language used by clinicians during inhalational induction of anesthesia on anxiety and negative behaviors in children. this is a prospective randomized parallel group trial. patients will be randomized 1:1 to the common/standard language group or the positive language group.


Eligibility criteria:
inclusion criteria: * asa 1 and 2 (healthy patients) * non-emergent cases * 5-10 year olds * patients receiving inhalational induction exclusion criteria: * non-english speaking * history of prior inhalational inductions * hearing difficulty * behavioral difficulty (autism, oppositional defiant disorder) * patients receiving premedication other than midazolam

Keywords: anesthesia induction
the effect of self-acupressure application on functional composite and quality of life in multiple sclerosis patients

Conditions: Multiple Sclerosis

Summary: it is important to consider the functional composite and quality of life of patients with multiple sclerosis (ms) and to plan interventions for these problems.

the application of self-acupressure helps in improving the functional composite and quality of life in multiple sclerosis patients.

Eligibility criteria:
inclusion criteria: * to be able to communicate adequately * not having psychiatric problems * volunteering to participate in research exclusion criteria: * none

Keywords: self-acupressure functional composite quality of life
national plaque registry and database

Conditions: Atherosclerosis; Coronary Artery Disease; Cardiovascular Disease

Summary: the ultimate goal of this project is to develop a risk score to identify patients with vulnerable coronary atherosclerotic plaques, who are prone to suffer acute coronary syndrome. early identification of vulnerable plaques may have an enormous impact on public health through primary and secondary prevention of acute myocardial infarction. investigators hypothesize that a risk score that incorporates non-invasive coronary ct imaging (calcium score and/or coronary cta) in combination with clinical characteristics (classical risk prediction models) will improve the identification of patients who are at highest risk to suffer myocardial infarction or sudden cardiac death. the overall goal of the opera project is to develop, implement and validate a novel risk assessment tool based on image markers and clinical characteristics to identify patients who are at increased risk to suffer myocardial infarction or sudden cardiac death.

the primary goals of opera consortium: to develop a national coronary cta registry with the collaboration of all major cardiac ct centers of hungary (országos plaque regiszter és adatbázis - national plaque registry and database, opera). 1. to develop a novel risk assessment tool (opera score) based on image markers and clinical characteristics. 2. to identify and validate novel vulnerable coronary plaque image markers and assess their prognostic value. secondary goals: 1. to develop a standardized and structured, national coronary cta reporting system. 2. to establish a national quality control system that monitors the quantity of iodinated contrast agent and the patients' radiation dose.

Eligibility criteria:
inclusion criteria: * age \> 18 years * subject providing written informed consent * scheduled to undergo a clinically indicated coronary cta exclusion criteria: * age \<18 years * suspicion of acute coronary syndrome (acute myocardial infarction and unstable angina) * recent prior myocardial infarction within 30 days prior to coronary cta or between coronary cta and ica * pregnancy or unknown pregnancy status in subject of childbearing potential * subject requires an emergent procedure * evidence of ongoing or active clinical instability, including acute chest pain (sudden onset), cardiogenic shock, unstable blood pressure with systolic blood pressure \<90 mmhg, and severe congestive heart failure (nyha iii or iv) or acute pulmonary edema * inability to comply with study procedures

Keywords: atherosclerosis coronary artery disease cardiovascular disease coronary computed tomographic angiography ccta myocardial infarction mi opera
comparison of ufr with qfr in stable coronary artery disease

Conditions: Coronary Artery Disease

Summary: quantitative flow reserve (qfr), derived from coronary angiography, has shown high accuracy in detecting significant lesions. ultrasonic flow ratio (ufr), a new development from ivus, integrates physiological estimation with intravascular imaging. although both qfr and ufr are effective, there's no conclusive evidence favoring one over the other. the study aims to compare ufr and qfr's diagnostic performance against the conventional ffr standard in detecting significant coronary lesions.

coronary artery disease (cad) remains a prevalent global health concern, necessitating precise diagnostic strategies for optimal patient management. fractional flow reserve (ffr), defined as the distal-to-proximal pressure ratio across a coronary stenosis during maximal hyperemia and typically measured by a pressure guidewire during coronary angiography (cag), is considered a gold standard tool for detecting ischemia-causing stenosis and guiding revascularization decisions. however, wire-based ffr has been significantly underutilized due to practical reasons, including its invasive nature and the requirement for hyperemia. consequently, there is growing interest in developing and validating computational ffr from anatomical information derived from cag and intravascular imaging modalities, such as intravascular ultrasound (ivus). quantitative flow reserve (qfr), derived from cag, has been extensively investigated and has demonstrated high diagnostic performance for detecting hemodynamically significant lesions. beyond cag, research has indicated that ivus imaging can also be utilized for computing ffr. ivus, a widely accepted and powerful modality for evaluating vessel luminal size and characterizing plaque morphology in the context of coronary intervention, has given rise to ivus-based ffr, known as ultrasonic flow ratio (ufr). ufr has been recently developed, integrating an estimation of physiology with intravascular imaging in the same ivus pullback. despite the proven effectiveness of both ufr and qfr, there is currently no evidence supporting the superiority of one technique over the other. in the present study, investigators aim to compare the diagnostic performance of ufr and qfr for the detection of functionally significant coronary lesions, using conventional ffr as the gold standard.

Eligibility criteria:
inclusion criteria: * patients who underwent both ivus imaging and ffr measurement on the same artery exclusion criteria: * inadequate quality of cag or ivus images for qfr or ufr calculation * left main or ostial right coronary artery lesion * the use of balloon predilatation or stent placement prior to ffr measurement or ivus imaging * incomplete ivus pullback across the entire lesion segment * the presence of a severe myocardial bridge (defined as ≥30% systolic diameter stenosis) in the examined vessel * history of previous coronary artery bypass grafting, * left ventricular ejection fraction \<35%
the effect of speed dependent treadmill training on dual task performance in patient with parkinson's disease.

Conditions: Parkinson Disease

Summary: the aim of this randomized clinical trail is to identify the impact of treadmill training on walking while doing dual task in patients with parkinson's disease. by improving walking speed, bradykinesia would be reduced in parkinson's patients. so, the findings of this study can help in formulation of future guidelines for management of parkinson's that will help the clinicians to treat such patients in more efficient way.

a rct that investigated the effect of treadmill training and physiotherapy in patient with pd using dual tasking as outcome measure.105 parkinson's disease (pd) patients; these are the subject who received treadmill training and physiotherapy for 14 days. both intervention helps the patients to enhance the dual task gait velocity. a study is to identify the effects of incremental speed-dependent treadmill training on postural instability and fear of falling in parkinson's disease to observe the postural stability by incremental speed dependent treadmill training. 54 patient of parkinson's disease (pd) was randomly allocated in to experimental and control group. 8-week training program was conducted including stretching, range of motion exercises (rom), and treadmill training. walking distance of the training group was gradually increased after 16 training sessions. the training group's scores on the berg balance test, dynamic gait index, and falls efficacy scale dramatically improved after the training program. while the control group, shows no significant improvement in outcome measurements. specific exercise regimens, such as incremental speed-dependent treadmill training, may increase mobility and minimize fear of fall in-patient with parkinson's disease. gap:the study's relatively small sample size is one of its limitations. there is least work done on speed dependent treadmill training and its effect on dual task performance in-patient with parkinson's disease. more research is require, to compare various treatment options with incremental speed-dependent treadmill training for parkinson's disease patients.

Eligibility criteria:
inclusion criteria: * able to walk on treadmill for 20 min * cognitively able to perform required task * hoehn and yarn disease stage between i to iii. exclusion criteria: * gait impairment * cardiac impairment * dementia * history of fall * severe freezing episodes * camptocormia (axial deformity) * central or peripheral paresis * score less than 20 in mini mental scale.

Keywords: treadmill training dual-task performance parkinson disease physiotherapy