Kornimate/medical-research-clean huggingface dataset:
characterization of the serotonin 2a receptor selective pet tracer [18f]mh.mz in patients with neurodegenerative diseases

Conditions: Neurodegenerative Diseases; Parkinson Disease; Parkinson Disease Psychosis

Summary: it is hypothesize that patients with clinically diagnosed neurodegenerative diseases will have significantly different receptor occupancy of 5ht2a receptors compared to a healthy age/sex-matched control group. this will be tested by measuring 5ht2a receptor density using the pet radioligand (r)-\[18f\]mh.mz in both populations.

it is hypothesized that improvement in psychosis symptoms in patients taking pimavanserin will be associated with increased baseline receptor density (hypothesis 1a), and increased receptor occupancy of 5ht2a receptors following pimavanserin administration (hypothesis 1b). this will be done by measuring 5ht2a receptor density using the pet radioligand (r)-\[18f\]mh.mz within predefined symptom networks for hallucinations, delusions, and sleep. a pet scan will be obtained in pd patients with psychosis at enrollment to measure baseline 5ht2a receptor density and then again after 6 weeks of pimavanserin. the change in binding between baseline and post-drug treatment window will be used to measure 5ht2a receptor occupancy. it is hypothesize that improvement in psychosis symptoms in patients taking pimavanserin will be associated with increased functional connectivity and cerebral blood flow within predefined symptom networks for hallucinations, delusions, and sleep. this will be tested by obtaining mri scans assessing resting state functional connectivity and arterial spin labeling in pd patients with psychosis at enrollment (baseline) and then again after 6 weeks of pimavanserin. it is hypothesized that functional neuroimaging changes in response to pimavanserin will be associated with baseline 5ht2a receptor density and 5ht2a receptor occupancy after pimavanserin administration. to test this hypothesis, the differences in functional neuroimaging measures and pet 5ht2a receptor will be measured in pd psychosis patients off (at baseline) and on pimavanserin (post-treatment window).

Eligibility criteria:
inclusion criteria: * patient arm - clinical diagnosis of parkinson disease, diffuse lewy body disease, multiple systems atrophy, huntington's disease, frontotemporal dementia, and other variants * healthy arm - age and gender matched to patient arm * psychosis (presence of hallucinations or delusions) starting after the diagnosis of parkinson's disease, occurring at least weekly for 4 weeks, severe enough to warrant treatment. * study partner available for study visits exclusion criteria: * prior stroke or other uncontrolled serious neurological or medical illness * contra-indication or inability to tolerate mri scan * use of serotonergic medications in the last 6 weeks * incapable of providing independent consent. * pregnant or breastfeeding women * psychosis due to a metabolic, toxic, or primary psychiatric disease * deemed unable to complete neurocognitive testing * for pd participants: current or prior use of pimavanserin * use of antipsychotics in the last 2 weeks
efficacy of online hemodiafiltrationlysis in cytokine removal

Conditions: Sepsis; Acute Kidney Injury

Summary: following the concept of "peak concentration hypothesis", which suggest the cutting peak of pro- and anti-inflammatory mediators would result in restoring a situation of immunohomeostasis. the investigators conducted the prospective randomized controlled trial aimed to compare the clearance efficacy between on-line hemodiafiltration and high-flux hemodialysis in sepsis-related acute kidney injury patients. the lowering cytokines level during sepsis is postulated to improved outcomes in sepsis.

1. blood samples were taken from patients before and at the end of 4-hour in the first dialysis session. the percentage of reductions were calculated from the before and ending samples. the values of postfilter samples were corrected for changes in plasma volume, based on hemoglobin (hb) of prefilter. 2. vegf and other cytokines (il-6, il-8, il-10, and tnf-α) were determined in the plasma separated from edta blood. after collection, plasma separation was achieved by centrifugation for 10 min at 1,500 g. immediately after separation, the samples were stored at -70 ºc until further analysis. 3. all determinations were carried out in duplicate. the panels of cytokines (vegf, il-6, il-8, il-10, and tnf-α) were measured using the luminex xmap-based multiplex technology. assays were performed using the milliplex map (multi-analyte panels) 5-plex cytokine kit (millipore, billerica, ma) on the luminex® instrument according to the manufacturer's procedure.

Eligibility criteria:
inclusion criteria: * sepsis * acute kidney injury (rifle classification f) * age more than 18 exclusion criteria: * hemodynamic instability * whom written informed consent could not be obtained
lymphovascular abnormalities under tattoos

Conditions: Tattoo

Summary: the number of tattooed people is increasing and some complications secondary to tattoos suggest that the lymphatic vascular system might be implicated in their pathogenesis. abnormalities have been described at the level of the lymph nodes draining the tattooed areas but nothing was reported about the lymphatic vessels under tattoos. this is the aim of the present work.

19 subjects with 20 tattooed skin surfaces were enrolled after written informed consent and the lymphvascular drainage under the tattooed surface was studied using one near infrared camera device after one intradermal injection of indocyanine green.

Eligibility criteria:
inclusion criteria: * presence of one tattoo at the level of one limb * written informed consent exclusion criteria: 1. history of iodine allergy or anaphylactic reactions to insect bites or medication; 2. hyperthyroidism; 3. severe cardiac or pulmonary disease; 4. significant renal failure (creatinine \> 400 μmol/l); 5. pregnancy; 6. any known disease of the skin (such as psoriasis); 7. any disease known to affect the cutaneous tissues (such as diabetes); 8. any previous operation and/or trauma at the level of tattooed limb; 9. familial history of lower limb edemas: 10. skin infection after the tattoo

Keywords: lymphatic vessels indocyanin green near infra red fluorescence lymphatic imaging tattoo
the eus shearwave elastography liver fibrosis study

Conditions: Liver Fibroses

Summary: the study objective is to demonstrate the clinical performance of shearwave elastography (swe) in endoscopic ultrasound (eus) when compared to fibroscan for evaluation of liver fibrosis.

this study has been designed as prospective, single center, single arm, consecutive, blinded, pilot study conducted in a post-market setting using commercially available devices to evaluate the effectiveness of endoscopic ultrasound with shearwave elastography to estimate hepatic fibrosis in patients with chronic liver disease. it is anticipated that the data from this study will support the need for additional clinical trials. all consenting, eligible patients reporting for an ultrasound and/or liver biopsy for evaluation of fibrosis meeting the inclusion criteria will be consecutively enrolled into the study and assigned a unique study identification number. a total of 52 subjects will be enrolled and treated at a single study site in the us. enrollment is expected to be completed within 6 months. each subject will undergo both procedures (fibroscan and eus with sw elastography), end of study will be reached after pathology results have been obtained (within a week of the initial procedure).

Eligibility criteria:
inclusion criteria: 1. ≥ 18 years of age 2. willing and able to provide informed consent 3. undergoing diagnostic eus procedure with liver biopsy 4. baseline cbc, cmp, inr within 3 months exclusion criteria: 1. contraindication to eus-guided liver biopsy 2. baseline platelet count \<50,000 3. baseline inr \>1.5 4. patient is a prisoner
rct comparing lightweight vs. heavyweight meshes in incisional hernia repair

Conditions: Incisional Hernia

Summary: in this randomized, controlled, prospective multicentre clinical trial with a parallel group design a large-pore, lightweight polypropylene mesh (ultrapro®) is compared to a small-pore, heavyweight polypropylene mesh (premilene®), within a standardized, retromuscular mesh augmentation to identify the superiority of the lightweight mesh. included patients are examined at five scheduled follow-up visits (5 and 21 days, 4, 12 and 24 months after surgery). the primary outcome criterion is foreign body sensation 12 month after surgery. further secondary endpoint criteria are the occurrence of haematoma or haematoma requiring surgery at the 5-day visit, seroma, wound infection, and chronic pain within 24 months postoperatively. quality of life was investigated by the sf-36®.


Eligibility criteria:
inclusion criteria: * fascial defect after vertical midline laparotomy with a minimum of 4 cm in diameter exclusion criteria: * hernia of other location * recurrent hernia * incarcerated hernia * emergency surgery * patients with a malignancy or chemotherapy within the last 3 months * pregnancy * participation in other studies * patients with a wound infection * missing informed consent
sns for treatment of pd gait disorder

Conditions: Parkinson Disease; Gait Disorders, Neurologic

Summary: parkinson's disease (pd) is a progressive disease, characterized by dopaminergic neurons degeneration in the substantia nigra. postural and gait disorders usually occur in advanced pd patients. however, existing drugs and deep brain stimulation (dbs) therapy are not effective enough for these axial symptoms or cannot maintain long-term efficacy, which seriously reduce patients' quality of life. sacral nerve stimulation(sns) is a treatment for urinary symptoms in pd. it has been reported that sns can also improve pd gait disturbance, but the level of evidence currently is low. we assume that sns may have a similar mechanism to spinal cord stimulation and may be an effective treatment for pd gait disorder. however, there are few studies on the mechanism of sns treatment. therefore, we will conduct a large sample, prospective case-control study to provide a higher level of clinical evidence for sacral nerve stimulation in the treatment of gait disturbance in pd. our primary objective is to evaluate the efficacy of sns for gait disorder in pd. pd patients who have received dbs surgery but still have severe gait problems will be included. this study will contribute to evaluate the efficacy of sns for gait disorder in pd, provide level ii evidence for expanding the indications of sns, varicocelectomy., and improve patients' quality of life.


Eligibility criteria:
inclusion criteria: * idiopathic parkinson's disease, hoehn \& yahr stage (medication off condition) at 2\~4; * gait and balance disorder, unstable posture, frequently falls (gaze and fall questionnaire (gfq) score \> 32) and severe dysuria, extremely affects quality of life (overactive bladder score (oabss) ≥12); * scs eligibility has been confirmed by neurologist and neurosurgeon; * patients willingly seek surgical treatment for pd gait disturbance； * ability to perform a gait/walking task (under close supervision); * informed consent and have good compliance. exclusion criteria: * lesion in spinal nerve or other surgical contraindications; * severe depression (beck depression inventory scores \> 25) or dementia (mini mental state examination \< 24); * medical history of stroke, amyotrophic lateral sclerosis or myasthenia gravis; * other neuropsychiatric disorders or relevant medical history; * taking prohibited medications (such as lithium, valproate, steroids, adrenergic agonists, etc.); * cardiac, renal or other important organs hypofunction or dysfunction, or unstable vital signs; * women reporting that they are pregnant; * any situation (medical, psychological, social, geographical, etc.) that may endanger patient's life or result in patients withdrawing from the study at present or in the future.
team elements associated with mortality in intensive care

Conditions: Intensive Care Unit Stay; Death

Summary: the individual characteristics and interactions of health care workers in intensive care units may influence patient safety. this study aims to quantify the influence of team familiarity among the members of medical and nursing staffs on risk of patient death.


Eligibility criteria:
inclusion criteria: * all patients who were admitted to 9 french intensive care units from january 1st 2011 to december 31st 2016 exclusion criteria: * patients admitted in pediatrics intensive care units and in specialized burns units
effects of thai dance with twenty-five squares in elderly with mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: the objective of this study was to determine the effects of thai dance with twenty-five squares on cerebrovascular and cognitive function in elderly with mild cognitive impairment

twenty elderly with mild cognitive impairment aged 60 years and over were randomized into 2 groups: control group (con; n=20) and thai dance with twenty-five squares training group (tdt; n=20). participants in con group do their daily routine without receiving any training program, while those in tdt group completed receiving thai dance with twenty-five squares training program three time a week for twelve week-long (60 minutes/time). the physiological data, cerebrovascular function, cognitive, respiratory function, health-related physical fitness, and blood biochemistry variables were analyzed during the pre-test and post-tests. the dependent variables between pre-test and post-tests were analyzed by paired t-test. the variables between pre-test and post-test were analyzed by paired t-test. in addition, an independent t-test was used to compare the variables between groups. statistical significance was defined as p \< .05.

Eligibility criteria:
inclusion criteria: * elderly males and females aged 60-79 years who can lead normal daily lives. individuals with mild cognitive impairment identified through the montreal cognitive assessment (moca) with a score in the range of 17 - 25. * must be able to listen, speak, read, write, and understand the thai language. * should not have diseases or abnormalities such as heart disease, eye complications caused by diabetes, uncontrolled high blood pressure, kidney complications caused by diabetes, and stroke. * must not have other respiratory diseases such as tuberculosis (tuberculosis), asthma (asthma), lung cancer (lung cancer), emphysema (emphysema), chronic obstructive pulmonary disease (copd), etc. * must be a person not at risk of falling, determined through a test of the ability to walk and turn 3 meters within a time period of 7 - 15 seconds. * must not have received medication to treat dementia. * should not have received exercise training for more than 20 minutes at a time, 3 days/week, or more in the past 6 months before participating in the research. * should not have symptoms of mental disorders such as schizophrenia, bipolar disorder, or depression. * should have passed the pre-exercise readiness assessment (par-q). * must be willing to participate in the research and sign the consent form to take part in the study. exclusion criteria: * a force majeure event, such as illness, that prevents participation in the research. * participation in less than 80% of the research sessions (must participate 29 times out of 36 times). * unwillingness to continue participating in the research.

Keywords: aerobic exercise elderly mild cognitive impairment cerebrovascular respiratory function
treatment of chronic pain using real time fmri

Conditions: Chronic Pain

Summary: the purpose of this study is to test a new investigational method for treatment of chronic pain using cognitive training guided by functional magnetic resonance imaging (fmri).

chronic pain is a substantial medical and economic problem, and is often unresponsive to conventional treatment. in this study, scientists will seek to decrease pain by increasing control over pain using newly-developed brain imaging methods to train people to control their own brain activation. this is the first clinical application of a recently-developed technology allowing a person to watch their own brain activation second-by-second and to learn to control it. it may provide a means to train people to control chronic pain by controlling their own brain states. the purpose of the study is to evaluate real-time functional magnetic resonance imaging (fmri) feedback for treating chronic pain diagnoses, including fibromyalgia, neuralgia, neuropathy, migraine, and complex regional pain syndrome (crps)/reflex sympathetic dystrophy (rsd). the study will also measure the impact of cognitive training for pain control on activations from the areas of the brain involved in pain. all participants in this study will receive a new form of cognitive training for controlling pain. participants will be scanned using fmri while they employ the cognitive training strategies-allowing them to view their brain activity. some participants will see their own brain activation during this process while other participants will see very similar but simulated data that does not come from their own brains. participation in the study will last about 6 months with 12 visits that includes 6 sessions in an mri scanner. recruitment for this trial is limited to persons in the san francisco bay area. participants must be able to attend sessions in menlo park, ca. participants will be reimbursed for travel time within the bay area. information gained from this study may help in developing potential future treatments for chronic pain.

Eligibility criteria:
inclusion criteria: * clinically diagnosed chronic pain. some example diagnoses include: crps, rsd, neuropathy, neuralgia, fibromyalgia, or migraine. * no implanted medical devices that are not compatible with mri (spinal cord stimulator/pump, pacemaker, surgical aneurysm clip, etc) * no recent history of severe psychiatric illness * weight less than 220 lbs. * able to be scanned in mri without claustrophobia * no facial tattoos, non-removable metal implants, piercings, or extensive dental work. * not pregnant or having fertility treatments

Keywords: chronic pain functional magnetic resonance imaging fmri cognitive training
transcranial magnetic stimulation in depression

Conditions: Depression

Summary: the study examines efficacy of repetitive transcranial magnetic stimulation in treating severely depressed patients who are medicated.

medicated, treatment resistant, depressed patients are randomized to active or sham repetitive transcranial magnetic stimulation (rtms). responding patients go into a six months follow-up period.

Eligibility criteria:
severe treatment-resistant depression
scapular flap versus obturator

Conditions: Maxillary Defect Reconstruction

Summary: the aim of this study was to evaluate and compare quality of life (qol) outcomes of scapular island flap versus maxillary obturator reconstruction after partial maxillectomy. patients indicated for maxillectomy were allocated randomly to two equal-sized groups. control group patients underwent reconstruction with a surgical obturator, while intervention group patients underwent scapular island flap reconstruction


Eligibility criteria:
inclusion criteria: * n0 lymph node * older than 18ys exclusion criteria: * patients who recived radiotherapy
safety and efficacy of antiadhesive barrier guardix-fl for women after laparoscopic cystectomy

Conditions: Genital Diseases, Female

Summary: * indication: benign tumors of ovary(mature teratoma, mucinous cystadenoma, serous cystadenoma) * intervention: device ( test group : guardix-fl, control group : interceed) * primary outcome measure : anti-adhesion rate * assessment : operative day(visit 2), post-operative day+7days(vist 3), post-operative day+4weeks(visit4), post-operative day+5weeks(visit 5)


Eligibility criteria:
inclusion criteria: 1. the patients who sign the written informed consent 2. women aged between 18 and 44 3. the patients who are able to participate in clinical trial during the period of study 4. the patients without abnormal figures at the screening laboratory examination 5. the patients expecting ovarian cystectomy for benign ovarian tumor(mature cystic teratoma, mucinous cystadenoma, serous cystadenoma) exclusion criteria: 1. the patients who took treatments with medical products which might be barrier to evaluate the effectiveness 2. the patients who took medicine like other anti-adhesion, absorbable hemostat and dose of steroid, immunosuppressants 3. the patients with severe drug allergy 4. the patients with infectious disease on abdominal or pelvic cavity 5. the patients who previously participated in another clinical trials within the past 30 days 6. the patients considered inappropriate for the study 7. the pregnant 8. the patients with severe renal disease 9. the patients with severe systemic diseases

Keywords: cystectomy
water method in patients with incomplete colonoscopy

Conditions: Failed or Difficult Intubation; Adenoma; Pain

Summary: water method with water exchange has been shown to reduce medication requirement and pain experienced during colonoscopy. it increases the success rate of cecal intubation in sedated and unsedated patients undergoing screening colonoscopy. exchange of water during scope insertion minimizes distension of the colonic lumen and decreases loop formation. exclusion of air from the colon during insertion by omission of air insufflations and suction removal of residual air prevent elongation of the colon. these maneuvers facilitate colonoscopy insertion in average patients and may enhance the success of difficult colonoscopy. colonoscopy has been considered the gold standard procedure in screening for colorectal disease. however, 5-10% of colonoscopies are incomplete due to patient discomfort, difficult anatomy and prior abdominal or pelvic surgery. the investigators postulate that these patients may benefit from using the water method for colonoscopy. in this proposal the investigators test the hypothesis that compared with conventional air insufflations the water method with water exchange significantly enhances the success rate of cecal intubation in patients with immediately failed colonoscopy. the aim of the study is to compare the outcome of colonoscopy using the water method versus the conventional air method in patients with incomplete colonoscopy. the primary outcome is cecal intubation success rate. the secondary outcomes include cecal intubation time, maximum pain score during colonoscopy, overall pain score after colonoscopy and adenoma detection rate.


Eligibility criteria:
inclusion criteria: * patients with incomplete colonoscopy exclusion criteria: * history of colorectal surgery * severe colonic stricture or obstructing tumor * patients who cannot give informed consent and those who are hemodynamically unstable

Keywords: colonoscopy water incomplete failed unsedated