Kornimate/medical-research-clean huggingface dataset:
brain computer interface complete locked-in state communication

Conditions: Complete Locked-in State

Summary: electroencephalography (eeg) and/or near-infrared spectroscopy (nirs) based brain computer interface for communication in patients without any means of communication.

amyotrophic lateral sclerosis is a progressive motor disease of unknown etiology resulting eventually in a complete paralysis of the motor system but affecting sensory or cognitive functions to a minor degree. there is no treatment available; patients have to decide to accept artificial respiration and feeding after the disease destroys respiratory and bulbar functions or to die of respiratory or related problems. if they opt for life and accept artificial respiration, the disease progresses until the patient loses control of the last muscular response, usually the eye muscles. if rudimentary voluntary control of at least one muscle is present the syndrome is called locked-in state (lis); ultimately as the disease progresses most als patients lose the control of all muscles, the resulting condition is called completely locked-in state (clis). patients in clis are unable to communicate with the external world because all assistive communication aids are based on some remaining motor control; hence there is a vital need for an assistive technology to help patients in clis to communicate needs and feelings to their family members/caregivers. brain computer interface (bci) represents a promising strategy to establish communication with paralyzed als patients, as it does not need muscle control. bci research includes invasive (implantable electrodes on or in the neocortex) and noninvasive means (including electroencephalography (eeg), magnetoencephalography (meg), functional magnetic resonance imaging (fmri), and near-infrared spectroscopy (nirs)) to record brain activity for conveying the user's intent to devices such as simple word-processing programs. non-invasive methods have been utilized more frequently than invasive methods for people with disabilities (such as those with als). for these conditions (lis and clis) brain-computer-interface were developed and tested extensively since the first publication of birbaumer, 1999 of two lis patients suffering from als. patients select letters or words after learning self-regulation of the particular brain signal or by focusing their attention to the desired letter or a letter-matrix and the attention related brain potential selects the desired letter. different types of bci based on eeg and/nirs is under development to provide a means of communication to patients who have none.

Eligibility criteria:
inclusion criteria: * amyotrophic lateral sclerosis patients without any eye movement exclusion criteria: * amyotrophic lateral sclerosis patients with intact eye movement

Keywords: non-invasive brain computer interface communication amyotrophic lateral sclerosis complete locked-in state
conventional versus led phototherapy and their effect on lymphocytes subsets of full term neonates with hyperbilirubinemia

Conditions: Neonatal Hyperbilirubinemia; Phototherapy Complication

Summary: the aim of this study is to investigate the influence of the use of different types of phototherapy on different lymphocytes subsets cd4 and cd8 in the treatment of hyperbilirubinemia in neonates.


Eligibility criteria:
inclusion criteria: term neonates with a gestational week higher than 37weeks, according to the guidelines of the american academy of pediatrics (2004) which stated that gestational ages of newborns are determined according to the first day of the mother's last menstrual period (by the mother's statement) and were additionally confirmed by the ballard scoring system (ballard et al., 1991) and antenatal ultrasonographic estimation or obstetric records if present. * clinically significant indirect hyperbilirubinemia requiring phototherapy in the first week of life. * no pathologic etiological factors for hyperbilirubinemia exclusion criteria: * total bilirubin level of \>20 mg/dl. * prematurity. * sepsis. * congenital anomaly. * elevation in direct bilirubin level. * history of immune deficiency the family. * history of preeclampsia or any other diseases or drug use of the mother
comparison of tap (transversus abdominis plane) and ilioinguinal/iliohypogastric nerve block for analgesia of open inguinal herniorrhaphy

Conditions: Pain

Summary: tap was recommended by prospect for further investigation as an appropriate analgesic method after open herniorrhaphy. ilioinguinal/iliohypogastric nerve block is one of the oldest methods of analgesia. the researchers wish to investigate whether the tap block is as effective as the ilioinguinal/iliohypogastric nerve block?


Eligibility criteria:
inclusion criteria: * patients undergoing elective primary unilateral open tension-free mesh inguinal hernia repair exclusion criteria: * inability to consent to the study * bmi more than 40 * skin infection near injection site * chronic hepatic or renal failure * peripheral neuropathy * proven opioid dependency * coagulopathy * thrombocytopenia * dementia * lack of orientation * impossibility to understand vas * patients suffering from chronic pain

Keywords: analgesia, postoperative
safety and efficacy study of the treatment of humerus fractures

Conditions: Acute Humerus Fractures

Summary: the purpose of this study is to collect safety and performance data on the use of the photodynamic bone stabilization system (pbss) when used to provide stabilization and alignment for the treatment of acute humerus fractures.


Eligibility criteria:
fracture-specific inclusion criteria 1. radiograph-confirmed diagnosis of acute, single isolated fracture of the humerus. ao classification 11a2, 11a3 and 11b1, 11b2 and 12a1, 12a2, 12a3 and 12b1, 12b2. 2. fracture is closed, gustilo type i or ii. general inclusion criteria 3. skeletally mature men and women, 50 years of age or older at time of index injury. 4. a) female patients of child bearing potential agree to use double barrier method of contraception b) female patients of non-child bearing potential must meet one of the following criteria: * postmenopausal for at least 1 year, or * documented oophorectomy or hysterectomy, or * surgically sterile 5. willing and able to understand and sign the informed consent. fracture-specific exclusion criteria 1. index treatment is greater than 28 days post fracture 2. open fractures with severe contamination. 3. extremely comminuted fractures where insufficient holding power of the balloon on the intramedullary canal is probable. 4. marked bone loss or bone resorption patients, who due to a prior delayed union or non-union of the bones or other illnesses, may not be able to have their fracture adequately reduced prior to placement of the illuminoss-device. this could leave bone void spaces that would preclude the device from maintaining alignment of the fractured bone. 5. previous fracture of affected limb. general exclusion criteria 6. pregnant or lactating. 7. active or incompletely treated infections that could involve the site where the device will be implanted. 8. distant foci of infections that may spread to the implant site 9. uncooperative patients or patients, who are incapable of following directions (for example as a consequence of a neurological or psychiatric disorder). 10. concomitant metabolic disorders that may impair bone formation. 11. osteomalacia. 12. allergic to implant materials or dental glue. 13. vascular insufficiency, muscular atrophy, or neuro-muscular disease. 14. polytrauma patients (multiple injuries resulting from a high-impact event, eg- a motor vehicle accident). 15. life expectancy less than one year due to concurrent illness.
supporting parents & kids through lockdown experiences (sparkle).

Conditions: Child Behavior Problem; Mental Health Issue

Summary: throughout the covid-19 pandemic, reduced access to childcare, money- and health-related worries and extended confinement and social isolation have placed great pressure on many families. there is evidence that many parents in the uk have struggled to manage their children's behaviour. for instance, co-space, an ongoing uk-wide study led by the university of oxford, found a significant increase in parents reporting behavioural problems in children and an increase in family-related stress in response to various local and national lockdowns. co-space has also found up to 70% of parents reported wanting additional support. the sparkle (supporting parents and kids through lockdown experiences) study aims to address this pressing need. sparkle is a rapid-deployment randomised controlled trial evaluating whether a digital public health parenting intervention can help parents to manage their children's behaviour problems, as impacted by the covid-19 uk pandemic and lockdowns. we aim to evaluate whether the negative effects of the pandemic can by reversed by providing parenting advice digitally, using a specially-designed app, parent positive. the parent positive app will provide advice to parents through animations, delivering messages carefully selected by parents and experts in the field. the messages will be supplemented with practical parenting resources and an opportunity to network with other parents for peer support. the animations are light-hearted, humorous and non-judgmental and are delivered by eight high-profile celebrities who are also parents. the sparkle study will involve 616 co-space parents, half of whom will receive access to the parent positive app and half who won't.


Eligibility criteria:
inclusion criteria: * the co-space inclusion criteria will apply: participant is willing and able to give informed consent, must be at least 18 years old and lives in the uk. * sparkle-specific criteria will be: participant (parent/caregiver) has a child aged 4-10 years and has access to a smartphone or tablet with operating system os 8-9 or higher (android devices) or ios 12-13 or higher (apple devices). exclusion criteria: * there will be no exclusion criteria. participants will not be selected on the basis of pre-existing child conduct problems.

Keywords: child behaviour problems parenting smartphone application covid-19 pandemic
attention deficit/hyperactivity disorder internet survey study in a college student population

Conditions: Attention Deficit Hyperactivity Disorder

Summary: attention deficit/hyperactivity disorder (adhd) is a common condition in young adults. there are many safe oral therapies that require daily use to be effective. because frequent follow-up visits have been shown to increase adherence to medication, we will determine if adherence to oral therapy for adhd will improve with an intervention involving weekly internet-based contact without an office visit. the primary aim is to determine the effectiveness of an internet-based survey in improving adherence to therapy for adhd. subjects in this study will be either receive a weekly internet-based survey assessing the prescribed medication and their adhd, or to receive standard-of-care therapy in which they will take their medication. the following hypothesis is to be tested: a weekly internet survey will promote improved adherence to oral adhd medications.

this is an investigator-blinded, prospective study of subjects diagnosed with adhd.forty-four subjects ages 18 years and older will be enrolled. an internet-based survey will be piloted to evaluate its effect on adherence to oral adhd medication. subjects randomized in a 1:1 ratio to the internet-survey group will log their impression of the state of their disease on a weekly basis. subjects in both the intervention and control groups will receive standard-of-care medication, stimulants. adherence to the medication will be assessed using medication event monitoring system (mems®) caps, electronic monitors affixed to the medication containers. investigators and subjects will be blinded to the adherence data until the final (month 2) treatment visit.

Eligibility criteria:
inclusion criteria: * any male or female 18 years or older of age with a diagnosis of mild to severe adhd by a psychiatrist at wake forest university student health clinic * use of the wake forest university student health clinic pharmacy to fill medication for adhd * subject is a good candidate to receive a stimulant for the treatment of their adhd * subject is capable of understanding and willing to provide a signed and dated written voluntary informed consent before any protocol specific procedures are performed * the subject is able to complete the study and comply with study instructions, including attending all study visits * will be filling a prescription for adhd exclusion criteria: * subject is less than 18 years of age * inability to complete all study-related visits or inability to complete the internet survey due to inadequate internet access * patients who are homicidal, suicidal, or psychotic * female patients whose medications may be harmful during pregnancy must be on an acceptable form of birth control, otherwise they will not be eligible for participation

Keywords: adherence internet-based
comparison of flexor retinaculum stretch and carpal mobilizations in patients with carpal tunnel syndrome.

Conditions: Carpal Tunnel Syndrome

Summary: comparison of flexor retinaculum stretch and carpal mobilizations in carpal tunnel syndrome patients.

* carpal bones mobilization tends to improve the symptoms of carpal tunnel syndrome. * manual stretching of the flexor retinaculum effective in cts patients. * as there are no studies available to compare the effectiveness of flexor retinaculum stretch and carpal bone mobilization for the treatment of cts, hence the purpose of this study is to find the effectiveness of carpal bone mobilization and flexor retinaculum stretch in improving pain, rom and functional status in patient with cts.

Eligibility criteria:
inclusion criteria: * females * age between 18-40 years * unilateral cts * already diagnosed patients of cts. exclusion criteria: * fracture of wrist * dislocation * congenital abnormalities * rheumatoid arthritis * osteoarthritis * liver failure * pregnancy * bilateral cts * systemic neurological condition e.g.: gb syndrome, multiple sclerosis.

Keywords: median neuropathy thenar muscle atrophy compression neuropathy flexor retinaculum
warrior care: cannabis behavioral health

Conditions: Post Traumatic Stress Disorder; Cannabis Use; Suicide; Veterans; Marijuana

Summary: this study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with ptsd and suicidal ideation.

in this clinical trial, we will recruit veterans with ptsd who report using cannabis or have interest in trying cannabis for symptom relief. veterans will be randomized into one of four different groups: thc (∆9-tetrahydrocannabinol), cbd (cannabidiol), thc+cbd, and placebo, and undergo a 12-week treatment phase where they will be asked to vaporize their assigned cannabis dose every day for 12 weeks. participants will complete weekly questionnaires regarding their mood, behavior and drug consumption. furthermore, there is a laboratory component that will assess cognition, fear conditioning, and other ptsd-related measures.

Eligibility criteria:
inclusion criteria: * able to provide informed consent, iq score \>80, * served in branch of the us armed forces, report using cannabis, * report using cannabis (no more than 2x in last month and no more than 100 lifetime use episodes) * meet dsm-5 criteria for ptsd w/ sx of at least 6 months duration exclusion criteria: * urine drug screen positive for any other drugs * systolic/diastolic bp \>140/90 mmhg? * any clinically significant medical problems, * any current or past serious psychotic or bipolar disorder diagnosis as determined by scid-5 * at immediate high risk for suicide based on the c-ssrs * current sud other than nicotine use disorder and alcohol use disorder (mild or moderate) * pregnancy, lactating * unable to provide informed consent
psoriasis and climate therapy- effect of motivational follow- up calls on clinical and health economic parameters

Conditions: Psoriasis

Summary: the aim of this study is to evaluate clinical and health economic parameters in relation to individual motivational counseling by phone.

a chronic condition such as psoriasis requires a high level of self- management and requires for many patients behaviour change to improve health outcome. changing behaviour is a challenge that requires a commitment by the patient to implement successfully. motivational interviewing is a patient centered directive counseling technique that focuses on assisting patients to identify their problems and involves exploring ambivalence in an empathic manner. it is a well-known method of counseling, and is considered to be a useful intervention strategy in the treatment of lifestyle problems. this study is a randomized controlled trial using telephone motivational interviewing. the counseling intervention comprises 6 telephone calls during a 12 week period, after attending 3 weeks of supervised climate therapy on the canary islands

Eligibility criteria:
inclusion criteria: * conducted 3 weeks of supervised climate therapy in the canary islands * able to write and communicate in norwegian * pasi more than 7 on application exclusion criteria: * more than 5 climate therapy treatments during the last 10 years

Keywords: motivational interviewing psoriasis self management
quality of life intervention for patients receiving radiation therapy for advanced cancer treatment and their caregivers

Conditions: Quality of Life; Advanced Cancer

Summary: this study will use video technology in conjunction with in-person participation. this is a pilot project, where all enrolled participants will receive the multidisciplinary intervention. participants (patients and caregivers) from mayo clinic rochester will attend an in-person group session, and participants (patients and caregivers) from mayo clinic florida or northfield mayo clinic radiation oncology center will participate through the use of video conferencing. the goals are to examine feasibility (percent of eligible patients and caregivers who enroll), attrition, and adherence (attend at least four of the six sessions), to determine any differences between the two formats, and to examine potential qol differences as a result of the intervention.


Eligibility criteria:
inclusion criteria: * 18 years of age. * ability to attend all treatment sessions and follow-up. * ability to provide written informed consent. * ability to participate in all aspects of the study. * initial diagnosis of cancer must have been 12 months prior to study entry. * intermediate to poor prognosis, defined as an expected 5-year survival of 0%-50% in the judgment of the physicians entering the patient on the study. * eastern cooperative oncology group (ecog) performance status (ps) 0, 1, or 2. * 1 week of planned cancer treatment (radiation or chemotherapy) at mayo clinic. * has a caregiver also willing to participate. * willingness to get e-mail/text reminder to complete the follow-up survey or complete the follow-up survey with a study coordinator by phone. exclusion criteria: * expected survival of \<6 months. * active substance abuse (alcohol or drug). * participation in other psycho-social research trials. * active untreated thought disorder (bipolar illness, schizophrenia, etc.). * untreated suicidal intent or plan. * in need of psychiatric hospitalization. * recurrent disease after disease-free interval of \>6 months. * previous cancer 5 years (except non-melanoma skin cancer and/or second cancer diagnosed at approximately the same time as this cancer). * use of proton beam radiation.
observational study of the wellinks solution impact on quality of life and clinical outcomes in patients with copd

Conditions: COPD; Chronic Obstructive Pulmonary Disease; Chronic Obstructive Pulmonary Disease Severe; Chronic Obstructive Pulmonary Disease Moderate

Summary: the clinical objectives of this study are to determine whether utilization of the wellinks copd solution can improve quality of life for patients with copd, can reduce healthcare resource utilization over time, and can improve pulmonary function as measured by connected devices. the nonclinical objectives of this study are to describe the experience of patients using the wellinks solution through the assessment of patient engagement with the solution, as well as by patient-reported satisfaction with the solution and their perceived value (e.g., willingness to pay). qualitative feedback on the features and functionality of the wellinks solution will be solicited.


Eligibility criteria:
inclusion criteria: * copd diagnosis (confirmed by the patient and assumed based on participation in copd pprn) * home telephone (landline or mobile) and internet access * smartphone: iphone 6s or later model, running ios 14.0 or later; android 6 or later model * proficient in english language * living/staying in the united states throughout the study duration * willing and able to comply with study requirements * able to provide written informed consent exclusion criteria: * current participation in other interventional clinical trials * current participation in a pulmonary rehabilitation program

Keywords: copd virtual care digital health v1c
preventive and therapeutic proximal sealants

Conditions: Dental Caries

Summary: it is of clinical importance to arrest the development of approximal caries at an early stage. the potential for initial caries to develop into manifest lesions has motivated studies on the use of sealants to arrest the progression of caries on both occlusal and approximal tooth surfaces. therefore, the aim of the present study was to follow-up and examine after 3.5 years, the efficacy of sealing caries-free or non-cavitated mesial surfaces of first permanent molars abutting lesions on the distal surfaces of second primary molars. the null hypothesis tested here was that preventive and therapeutic sealants do not prevent the development or slow the progression of dental caries over a period of 3.5 years in comparison to non-sealed control surfaces.

the study population comprised 121 schoolchildren aged 8 to 10 years in a high-caries community in valparaiso, chile. they were examined clinically and radiographically, divided into 3 groups, and treated accordingly: children in group a had no carious lesions on the approximal surfaces of 05d-6m and received no sealants; those in group b had active caries on 05d and received a preventive sealant on the caries-free 6m; and those in group c had active caries on 05d with an initial active lesion on 6m and received a therapeutic sealant on 6m. after 3.5 years, standardized follow-up radiographs were obtained for the children that remained.

Eligibility criteria:
inclusion criteria: * children with high rate of caries in the primary dentition * active caries on the distal surfaces of the second primary molars at least on both sides of the mouth * children with no lesions on the adjacent tooth surfaces on the second primary and first permanent molars were included as a general control group exclusion criteria: * children using medication containing sucrose or with a negative effect on salivary flow * children using orthodontic devices * children who refuses to participate

Keywords: dental caries risk assessment approximal sealant permanent molar preventive dentistry adolescent