Kornimate/medical-research-clean huggingface dataset:
comparison of efficacy of single oral dose fluconazole and itraconazole in patients with pityriasis versicolor

Conditions: Tinea Versicolor

Summary: pityriasis versicolor (pv) also called tinea versicolor is a common superficial chronic fungal infection of the skin caused by species of lipophilic yeast known as malassezia species. itraconazole is an oral synthetic triazole while fluconazole is an oral synthetic bis-triazole compound. only a few studies are available to find a direct comparison of the efficacy of single dose of oral fluconazole (400 mg) and oral itraconazole (1000 mg) in the treatment of pv. the objective of the study was to compare the efficacy of single dose fluconazole (400 mg stat) to single dose itraconazole (1000 mg stat) in the treatment of pityriasis versicolor in the local population of pakistan.

pityriasis versicolor (pv) also called tinea versicolor is a common superficial chronic fungal infection of the skin caused by species of lipophilic yeast known as malassezia species. itraconazole is an oral synthetic triazole while fluconazole is an oral synthetic bis-triazole compound. these both acts by inhibiting the cytochrome-p450 dependent 14-alpha-demethylation step in the formation of ergosterol thereby impairing the functions of certain membrane bound enzyme systems, and ultimately inhibiting the growth of fungi. both the drugs have been studied in different dose regimen, however, there are variable results in studies on this subject. there is still no standard drug and its dosage that can ensure complete cure. fluconazole (300mg) in 2 doses with an interval of one week has been used effectively, however, fluconazole (400 mg) as a single dose has also been used, and found to cure the pv. itraconazole 200 mg/day can be given in a dose of for 7 days however, higher concentrations of itraconazole in the stratum corneum are achieved that persist for 3-4 weeks so the drug is presumed to be effective even in a single dose. therefore, only a few studies are available to find a direct comparison of the efficacy of single dose of oral fluconazole (400 mg) and oral itraconazole (1000 mg) in the treatment of pv. the objective of the study was to compare the efficacy of single dose fluconazole (400 mg stat) to single dose itraconazole (1000 mg stat) in the treatment of pityriasis versicolor in the local population of pakistan.

Eligibility criteria:
inclusion criteria: * all the patients above 18 years of age * diagnosed with pityriasis versicolor exclusion criteria: * those patients who had received any antifungal treatment during last 1 month * pregnancy * lactation * history of renal disease hepatic disease or malignancy * history of hepatic disease * history of malignancy
magnetically navigated vs. manually guided radiofrequency in atrioventricular-node-reentry-tachycardia

Conditions: Atrioventricular Nodal Reentry Tachycardia; Radiofrequency Ablation

Summary: the magma-avnrt study compares two different methods of handling the ablation catheters for av-node-reentry-tachycardia with regard to x-ray dose, safety and success: manually guided vs magnetically navigated rf-catheter.

av-node reentry tachycardia can be treated by radiofrequency ablation or modulation of the slow pathway of the av node. the success rate is 90 to 95%. there are different options to navigate the ablation catheter: manually guided vs magnetically guided. for magnetic guidance two magnets are positioned beneath the patient. a mangetic field is induced and a catheter with a ferromagnetic tip can be navigated from outside with a joystick by modifying the vectors of the magnetic field. we hypothesized that a magnetic guidance of the rf-ablation catheter results in lower x-ray time and dose for the patient and the physician with comparable safety und success rates.

Eligibility criteria:
inclusion criteria: * 18 to 70 years old * suspected av-node-reentry-tachycardia * written informed consent exclusion criteria: * pregnancy * contraindication against electrophysiological study or ablation * congenital heart disease or other anatomical abnormalities * previous surgical procedure involving atrium except aorto-coronary bypass grafts * psychiatric disease that makes a completion of study improbable * severe comorbidities with a life expectancy less than 6 months

Keywords: av-node reentry tachycardia radiofrequency ablation magnetic navigation system
effect of hemodialysis on toe pressure- and finger pressure and skin autofluorescence in hemodialysis patients

Conditions: End Stage Renal Disease

Summary: the aim of this study is to determine the vascular condition of hemodialysis patients with toe pressure measurement, finger pressure measurement and measuring glycated and oxidated proteins by skin autofluorescence. hypothesis: lowering of finger pressure/toe pressure during hemodialysis, especially in whom with a arteriovenous fistula, may contribute to critical limb ischemia in the extremities.

1. to determine the macrovascular status of hemodialysis patients by measuring toe pressure, finger pressure and skin autofluorescence. 2. measuring toe- and finger pressure before and during hemodialysis to determine the chance of developing critical limb ischemia in the extremities. 3. to assess the differences in finger pressure in hemodialysis patients before and during hemodialysis in patients with either arteriovenous fistula in the upper extremity or not. 4. to predict mortality and cardiovascular disease by determine the fastness of accumulation of advanced-glycation-endproducts (this concerns follow-up measurements of skin autofluorescence; another study has collected data of skin autofluorescence in hemodialysis patients in our centre in 2003)

Eligibility criteria:
inclusion criteria: * patients with end stage renal disease with hemodialysis therapy exclusion criteria: * hemodialysis during the night * dark coloured skin towards unreliable skin autofluorescence measurements

Keywords: end stage renal disease hemodialysis critical limb ischemia autofluorescence
short versus conventional plaster cast fixation time in reduced distal radius fractures

Conditions: Colles' Fracture

Summary: the purpose of this study is to compare the radiographic and clinical outcomes after short versus conventional plaster cast fixation time in reduced distal radius fractures.

displaced distal radius fractures treated with closed reduction and plaster cast fixation are radiographed 10 days (range 8-13 days) after reduction and randomized to one of two study arms; immediate removal of plaster cast or continued fixation in plaster cast for another 3 weeks. radiographic and clinical outcome measurements at 1, 4 and 12 months

Eligibility criteria:
inclusion criteria: * distal radius fracture with intact ulna (except for processus styloideus ulnae) * dorsal angulation 5-40 degrees * axial compression \< 4 mm * intra articular step-off \< 1 mm * low energy trauma * closed fracture * suitable for treatment with closed reduction and plaster cast fixation exclusion criteria: * fracture older than 3 days * previously fractured ipsi- or contralateral wrist * dementia * inflammatory joint disorder
psychosocial wellbeing following stroke

Conditions: Psychosocial; Narrative; Coping; Quality of Life

Summary: the purpose of this feasibility study is to develop and initially test a dialogue-based psychosocial intervention aimed at promoting coping and psychosocial wellbeing following an acute stroke. the intervention is carried out by primary care registered nurses or other appropriate health professionals. the intervention included persons with and without aphasia.


Eligibility criteria:
inclusion criteria: * 18 years old or above * acute stroke * 4-8 weeks poststroke exclusion criteria * other serious disease

Keywords: stroke psychosocial intervention quality of life
effect of an education programme for patients with osteoarthritis in primary care - a randomized controlled trial

Conditions: Osteoarthritis in the Hip, Knee and Hand

Summary: osteoarthritis is a common disease. the core treatment is often patient education. the aim of this study is therefore to study the effect of a patient education programme for patients with osteoarthritis in primary health care.

osteoarthritis (oa) is a degenerative disease, considered to be one of the major national diseases that cause suffering for affected patients and costs for society.the predominant symptoms are pain, stiffness and impaired quality of life, often together with psychological distress. treatment often consists of medication. later in the disease, when the joint is destroyed, joint replacement surgery commonly occurs. physical exercises aimed to increase muscle strength, endurance, proprioception and stability have proved to influence cartilage as well as function, symptoms and quality of life positively. physical exercise may also reduce the need for hospital care after knee joint replacement. research suggests that patient education is feasible and valuable in terms of improvements in quality of life, in function, in well-being and improved coping . accordingly, guidelines recommend education as a core treatment for osteoarthritis. patient education programmes are often defined as a planned learning experience to influence a patient's knowledge and health behaviour \[13\]. there are various types of patient education. it can be given by a physician as part of consultation, in small groups or delivered by a multi-disciplinary team \[13, 14\] since 1994, primary health care in malmö has used a patient education programme directed towards oa. the programme has been developed by physiotherapists and occupational therapists in primary health care and has been implemented in the ordinary work.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of osteoarthritis exclusion criteria: * must be able to speak and understand swedish

Keywords: osteoarthritis patient education function physio therapy
westeinde brachialgia study

Conditions: Radiculopathy, Cervical

Summary: the westeinde brachialgia study (web) is a randomized controlled trial to establish the effect of cervical collar or physiotherapy compared to a wait-and-see policy in patients with acute cervical radiculopathy.

cervical radiculopathy caused by spondylosis or disc protrusion is a common disorder with a usually benign natural course. often, physiotherapy (exercise programs) and/or cervical collar are prescribed. however, there are no reliable data on the effects of these conservative therapies. in this study, patients with acute cervical radiculopathy, defined by clinical criteria, are randomized for cervical collar, physiotherapy or a wait-and-see policy.

Eligibility criteria:
inclusion criteria: * cervical radiculopathy defined by neck pain irradiating to one arm with at least one of the following: provocation by neck movements or sensory changes in one or more adjacent dermatomes or diminished deep tendon reflexes in the affected arm; or muscle weakness in one or more adjacent myotomes. exclusion criteria: * arm pain existing longer than one month * clinical signs of spinal cord compression * previously treated with physiotherapy or a cervical collar

Keywords: cervical radiculopathy conservative treatment
use of botox in the management of thyroid related upper eyelid retraction

Conditions: Graves Ophthalmopathy

Summary: currently there are few therapeutic options for the treatment of lid retraction secondary to thyroid orbitopathy (to) during the active stages of the disease. botox injection is capable of creating a ptosis, that in the setting of to can return the upper lid to a more physiologic position, thus improving cosmesis, corneal lubrication and potentially quiescent stage lid position. this investigation aims to examine the properties of this relationship.


Eligibility criteria:
inclusion criteria: * active stage thyroid orbitopathy, as determined by symptom onset of under 6 months. * upper eyelid retraction of 1mm or greater. * complaining of either significant ocular symptoms (despite appropriate use of ocular lubricants), or bothered by the cosmetic deformity associated with the eyelid retraction. exclusion criteria: * less than 18 years of age * age over 65 years * pregnant or nursing * known peripheral neuropathy or neuromuscular junction disorder * demonstrated allergy to botox * current infection over the injection site * are currently taking any of the following medications: aminoglycosides, penicillamine, quinine, and calcium channel blockers. * previous or concurrent prednisone therapy * undergone previous upper eyelid surgery * severe vision threatening to

Keywords: eyelid retraction botulinum toxins
vaginal misoprostol in management of first trimester missed abortion.

Conditions: Abortion, Missed

Summary: the world health organization defined abortion or miscarriage as : the expulsion or extraction from its mother of a fetus or an embryo weighting 500 grams or less ,or any other wise product of gestation of any weight irrespective of gestational age and weather or not there is evidence of life and weather or not the abortion was spontaneous or induced miscarriage is the most common complication of pregnancy occurring in 10-20% of clinically recognized pregnancies (bag. it is estimated that around 40% of early pregnancies result in miscarriage. a large majority of those are lost before the menstrual period is missed. more than 80%of abortions occur in first 12 weeks of pregnancy, and the rate decrease there after for clinical purposes: abortion is subdivided into: threatened abortion, inevitable abortion, incomplete abortion ,missed abortion ,septic abortion ,and recurrent abortion


Eligibility criteria:
inclusion criteria: * single dead fetus up-to 12 weeks. * no low lying placenta * no scarred uterus * no or mild bleeding * no evidence of infection * accepting to participate in the study. exclusion criteria: * advanced hepatic diseases . * suspected molar pregnancy * ectopic pregnancy or pregnancy of unknown location * haemodynamically unstable with significant anaemia ie hb\<10 * uncontrolled severe asthma * chronic adrenal failure * known or suspected heart disease * glaucoma * haemoglobinopathies * haemorrhagic disorders and anti-coagulation therapy (aspirin accepted) * adrenal suppression and long term glucocorticoid therapy (may require corticosteroid) * patient living in remote areas with difficulty in accessing hospital
safety and efficacy study of cubicin (daptomycin) under conditions of actual use

Conditions: Complicated Skin and Skin Structure Infections and Bacteremia Including Right-sided Endocarditis

Summary: the purpose of this study is to monitor the safety and efficacy of cubicin under conditions of actual use in patients who are diagnosed with complicated skin and skin structure infection (cssi) or staphylococcus aureus bacteria including right-sided endocarditis and are prescribed cubicin by their physician.


Eligibility criteria:
inclusion criteria: * diagnosis of csssi known or suspected to be due to gram-positive bacteria * diagnosis of right-sided endocarditis with one or more positive culture for s. aureus within two days prior to initiation of medication * prescribed daptomycin by patient's attending physician exclusion criteria: * known allergic or serious adverse reaction to daptomycin * patients with pneumonia * patients with baseline cpk values \>1000 u/l or 5x uln

Keywords: daptomycin endocarditis complicated skin and skin structure infection
a trial investigating the effect of nn1250 in japanese subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in europe. the aim of this clinical trial is to investigate the pharmacodynamic (the effect of the investigated drug on the body) properties of nn1250 (insulin degludec) in japanese subjects with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * male or female japanese subject aged 20-70 years (both inclusive) * japanese passport holder * japanese-born parents * type 2 diabetes mellitus (as diagnosed clinically) for at least 12 months * treated with insulin for at least 3 months * body mass index (bmi) maximum 33.0 kg/m\^2 * glycosylated haemoglobin a1c (hba1c) maximum 10.0% * fasting c-peptide below 1.0 nmol/l exclusion criteria: * use of oral antidiabetic drugs (oads) and/or glucagon like peptide-1 (glp-1) receptor agonists (exenatide, liraglutide) within 3 months prior to screening * subject who has donated any blood or plasma in the past month or more than 500 ml within 3 months prior to screening * not able or willing to refrain from smoking and use of nicotine gum or transdermal nicotine patches during the inpatient period * supine blood pressure at screening (after resting for 5 min) minimum 180 mmhg for systolic and/or minimum 100 mmhg for diastolic
reliability and validity study of urdu version of modified barthel index in stroke patients

Conditions: Stroke

Summary: aim of the study is to translate and culturally adapt the modified barthel index into urdu language and to investigate the reliability and validity of this scale in urdu speaking stroke population for performance evaluation. also check its correlation with functional independence measure and katz index of activities of daily living.

the english version of the barthel index will be translated and traditionally adapted as prior endorsement. in activities of daily livings disabled stroke population, urdu version of modified barthel index will distributed among sixty participants choose by convenience sampling technique based on pre-distinct inclusion and exclusion standards. to test inter and intra-observer reliability of the final urdu version of modified barthel index will be completed on the same day, by two observers, and for the inter-observers evaluation, with an interval of 30 minute between the first and the second submission. third evaluation will be carried out after 7 days by observer-1, for intra-observer assessment. data will be entered and analyzed using statistical package of social sciences version 24. core steadiness will be analyzed with cronbach alpha value. test-retest reliability will be evaluated using an intra-class correlation coefficient.the urdu version of modified barthel index will be evaluated for content validity, construct validity, criterion validity and responsiveness.

Eligibility criteria:
inclusion criteria: * male and female both genders * adults between the ages of 18 and above * patient suffering from stroke * ability to provide informed consent exclusion criteria: * suffering from any cardiovascular pathologies * any disorder of contagious infections * any history of neurological disorders * having any spinal deformity

Keywords: modified barthel index urdu version reliability validity cerebrovascular disease stroke activities of daily living
echocardiographic assessment of ventricular strain during a healthy pregnancy in the first, second, and third trimester.

Conditions: Echocardiography; Pregnancy Related Conditions, Unspecified, First Trimester; Pregnancy Related Conditions, Unspecified, Second Trimester; Pregnancy Related Conditions, Unspecified, Third Trimester; Ventricle Remodeling

Summary: pregnancy is a physiological situation that produces transient preload and afterload changes. the heart is subjected to reversible morphological remodelings and hemodynamic and functional adaptations. the characterization and understanding of maternal cardiac function during normal pregnancy by echocardiography 2d is of clinical importance for the opportune recognition of cardiac pathology. this study aims to investigate pregnancy-induced changes in ventricular strain in healthy pregnant women by echocardiography.


Eligibility criteria:
inclusion criteria: * age ≥18 years and \< 35 * patients who coursing the first trimester of pregnancy * no history or symptoms of cardiovascular or lung disease * no ongoing or previous cardio or vasoactive treatment * normal ecg * normal physical examination * able to give informed consent exclusion criteria: * poor acoustic window * obesity in the first trimester (body mass index \[bmi\], ≥30 kg/m2) * inability to provide consent. * tricuspid regurgitation more than mild * collagen disease * professional sports activity * twin pregnancy * hyperthyroidism

Keywords: strain ventricular pregnancy ventricular function
barriers to substance use disorder recovery

Conditions: Substance Use Disorders

Summary: the study purpose is to investigate how an inpatient recovery coaching intervention can overcome or mitigate specific risk factors and barriers to initiating and maintaining substance use disorder recovery. this study will offer insight into how and why an inpatient link to recovery coaching is effective for promoting long-term substance use disorder recovery.

substance use disorder (sud) is a prevalent disease that impacts an estimated 24 million americans each year. the life-altering consequences of sud are both diverse and severe, influencing mortality, the workplace, and economics. the goal of this study is to determine how specific risk factors of relapse and barriers to recovery, including neurocognitive, health, personal, social, financial, and situational barriers, can be overcome or changed through a recovery coaching intervention. this work seeks to provide a mechanism to demonstrate exactly how and why this potential new model of care (recovery coaching) is effective, rather than simply assessing if it can work. to accomplish this aim, the change between baseline and 6-month assessments will be assessed. then, the difference in the change between individuals assigned to the current standard of care and patients assigned to inpatient recovery will be compared.

Eligibility criteria:
inclusion criteria: * age 18 - 60 * english speaking; * identified by healthcare provider as having substance use disorder * recent substance use * currently admitted to the medical teaching services, general medicine hospitalist services, or infectious disease consult service at greenville memorial hospital exclusion criteria: * are unable to provide informed consent (intubation, confusion, etc.) during hospitalization * are admitted for marijuana use only * are admitted for cocaine use only * are pregnant

Keywords: recovery coaching risk factors substance abuse eeg
the efficacy of vespa 2.0 for cognitive rehabilitation in patients with mild cognitive impairment

Conditions: Neurodegenerative Diseases; Cognitive Decline; Parkinson Disease Dementia; Alzheimer Disease; Multiple Sclerosis

Summary: vespa 2.0 is based on an integrative and ecological approach used for the treatment of cognitive dysfunction in patients with mci or other neurodegenerative disorders.

the goal of this study is to verify the effectiveness of the intensive-individual cognitive participation intervention (sci-i) on the general cognitive functioning and specific cognitive functions of patients with mild or moderate cognitive decline affected by alzheimer's dementia, parkinson's and multiple sclerosis. participants will be subjected to cognitive training (tasks on attention, memory, language, executive functions, and visual-spatial functions) through software. they will take place using virtual cameras and virtual reality (vr) viewers. all subjects will undergo follow-up evaluation.

Eligibility criteria:
inclusion criteria: * patients diagnosed with alzheimer disease, multiple sclerosis, parkinson disease * severity of mild to moderate cognitive impairment * sign informed consent exclusion criteria: * important comorbidities with psychiatric syndromes * failure to sign the informed consent * atypical parkinsonisms * clinical conditions that involve vision-related problems.