Kornimate/medical-research-clean huggingface dataset:
comparison of facility and home-based art delivery systems in uganda

Conditions: AIDS

Summary: the study is a 3-year, randomized trial to compare art delivery through two different models: a) art delivered through health facilities by clinically qualified staff and b) home-based care in which lay workers, i.e. non-medically qualified people, play a major role in the art delivery and clients are followed up at health facilities less frequently. the primary objective is to measure the effects of these strategies on hiv viral load. we will also examine the effects on treatment failure, disease progression, survival, adherence, family member hiv testing, sexual behavior, and cost-effectiveness.

the study is a randomized trial to compare art delivery through two different models: a) art delivered through health facilities by clinically qualified staff and b) home-based care in which lay workers, i.e. non-medically qualified people, play a major role in the art delivery and clients are followed up at health facilities less frequently. the primary objective is to measure the effects of these strategies on plasma hiv viral load. we will also examine the effects on treatment failure, disease progression, survival, adherence, family member hiv testing, sexual behavior, and cost-effectiveness. the trial is conducted with the aids support organization (taso) clinic in jinja, uganda. randomization is conducted through geographic clusters, defined using sub-counties in the district, and stratified by distance from fixed health facilities, and urban/rural. just over 800 participants, living in 40 clusters, will be recruited over a period of 3-6 months and followed-up over a period of 3 years.

Eligibility criteria:
inclusion criteria: hiv infection plan to remain resident in the area for at least 12 months cd4 cell count \<200 cells/mm3 or severe symptomatic hiv (who stage 3 or 4) identify a medicine companion who will assist in adherence to art treatment age 18 years or above. exclusion criteria: abnormal liver and renal function test results (ast or alt ≥ 5x upper limit of normal calculated creatinine clearance \< 25 ml/min). the tests are conducted only in individuals in whom they are clinically indicated

Keywords: hiv africa adherence hiv viral load sexual behavior voluntary counseling and testing
horse-assisted intervention, heart rate variability & stress

Conditions: Psychological Stress

Summary: in this study, the effects of an animal-assisted intervention on people with increased stress levels are investigated. the data collected will be compared with those of participants with high stress levels but without animal-assisted intervention (participants only observe nature) and with a control group consisting of people without stress exposure. the study will be performed in the following setting: questionnaire examination on chronic stress, questionnaire on current well-being and heart rate variability (hrv) measurement before the horse-assisted intervention, one hrv measurement and one questionnaire examination (poms) on current well-being after the horse-assisted intervention, one questionnaire (poms) on current well-being 5 days after the horse-assisted intervention.

the early recognition of chronic stressors, which are often neglected by those affected until physical symptoms appear, is of essential importance. in addition to psychopharmacological therapy modalities, complementary methods such as animal-assisted intervention should also be considered in order to expand the therapeutic spectrum and thus prevent stress-associated consequential harms as early as possible. stress has gained importance in recent years not only in the medical context, but also due to its economic relevance. chronic stress in particular leads to numerous medically relevant secondary diseases and to increased sick leaves and even permanent incapacity to work. one possible intervention to reduce stress could be animal-assisted intervention. primary hypothesis: the use of animal-assisted intervention in people diagnosed with chronic stressful situations will lead to measurable increases in heart rate variability. secondary hypothesis: the use of animal-assisted intervention in people diagnosed with chronic stressful situations leads to improved well-being (target parameter: poms questionnaire)

Eligibility criteria:
inclusion criteria: * male, female and diverse * age between 18-75 years exclusion criteria: * animal hair allergies (especially horse hair allergies, fear of horses) * acute severe psychiatric conditions (e.g. psychosis) * persons, unable to give signed informed consent, * all persons, who have not signed the informed consent form.

Keywords: psychological stress animal-assisted intervention
inflammatory markers in hysterectomies

Conditions: Gynecologic Disease; Inflammation

Summary: this retrospective study was conducted in the obstetrics and gynecology clinic at derince training and research hospital. the study group was identified as patients who underwent hysterectomy between 2018 and 2019. our hospital is a 50-bed tertiary reference center where approximately 3,500 births per year occur, and about 500 gynecological-oncological surgeries are performed annually. the records of patients who underwent lh and ah were reviewed retrospectively. preoperative and postoperative blood values in the first 24 hours after surgery were compared: hematocrit (hct), hemoglobin (hb), wbc, plr, and nlr values were compared as well as the demographic characteristics of the patients who underwent these procedures. in addition, to evaluate the effect of ovaries on the inflammatory markers, the patients were divided into two groups: oophorectomy and non-oophorectomy. in our clinic, the decision to perform a hysterectomy is made by the weekly gynecology council. the type of surgery is determined according to the clinical condition of the patient, the gynecological examination, and the patient's request. in general, open surgery is preferred in patients with giant fibroids, many previous surgeries, and immobile uteri. conditions such as dysfunctional uterine bleeding, cervical intraepithelial neoplasms, and uterine descensus indicate the need for lh. in cases where there is no clinical suspicion, oophorectomy is performed according to the patients' wishes. in benign cases, the preferred type of hysterectomy is type 1 extra facial hysterectomy. in lh, the procedure is performed as follows: the uterine manipulator is inserted vaginally. first, a veress needle and then a trocar are entered through the umbilicus. the abdomen is insufflated with carbon dioxide, and the appropriate number of ports is placed. uterine ligaments and vessels are cut by using bipolar energy. the uterus is removed through the vagina, and the vaginal cuff is sutured laparoscopically. patients with chronic diseases (e.g., hypertension, diabetes mellitus, and rheumatologic, nephrological, and hematological diseases), the presence of active infection, corticosteroid use, acetylsalicylic acid, and anticoagulant use were not included in the study. bladder and bowel injuries, blood transfusion requirements, wound infection and hematoma, postoperative respiratory system complications (e.g., atelectasis) were evaluated as surgical complications.


Eligibility criteria:
inclusion criteria: * total or abdominal hysterectomy exclusion criteria: * hypertension, diabetes mellitus, rheumatologic, nephrological, and hematological diseases), the presence of active infection, corticosteroid use, acetylsalicylic acid, and anticoagulant use were not included in the study.

Keywords: hysterectomies inflammation mediators lymphocyte
children affected by rare disease and their families network

Conditions: Rare Diseases

Summary: families of children with rare diseases (i.e., not more than 5 out of 10.000 people are affected) are often highly burdened with fears, insecurities and concerns regarding the affected child and his/her siblings. the project at hand will test two innovative forms of care (care-fam and wep-care) at 17 sites in 12 federal states of germany. the goal is to improve the mental health and quality of life of children affected by rare diseases and their relatives in a sustainable manner. if successful, these interventions will be introduced into regular care.

the central objective of the study at hand is to close the supply gap for families with children and adolescents affected by rare diseases. two innovative forms of care (care-fam and wep-care) will be implemented and evaluated at the 18 participating study sites. both interventions include psychological diagnostics, early detection and treatment of concomitant mental diseases. the study is a prospective, randomized controlled multicenter study (rct) with a factorial design with four groups: carefam (face to face), wep-care (online), both interventions, control group (tau = treatment as usual). central psychosocial outcomes will be assessed at four time points (i.e., baseline and after six, 12 and 18 months) from the perspectives of the parents, the affected child and the siblings (0 - 9 years only external assessment; from 10 years of age additional self-assessment) and the professionals.

Eligibility criteria:
inclusion criteria: 1. family with at least one child between 0 and 21 years with a rare disease or a suspected rare disease. 2. consent to participate in the study. 3. sufficient knowledge of the german language of parents and children. 4. insured at the participating insurance companies. exclusion criteria: severe psychiatric disorders and impairments with acute symptoms such as suicidal tendencies, severe depression, addictions, acute psychotic symptoms etc., which will not be sufficiently supplied by this new low-frequency intervention. children and parents with acute treatment demand in the control group will be placed at psychotherapists. nevertheless, they stay in the control group.

Keywords: rare disease children and adolescents e-mental health early detection and early treatment of mental disorders
liposomal bupivacaine in total knee arthroplasty

Conditions: Knee Osteoarthritis; Anesthesia, Local

Summary: pain management after total knee arthroplasty is essential for optimized clinical outcomes and higher satisfaction. exparel (pacira pharmaceuticals, parsippany, new jersey, usa) is a long-acting bupivacaine extended release liposome compound that is injected peri-articularly or as regional block. the purpose of this study was to compare the analgesic efficacy of single administration of exparel for local peri-articular infiltration versus adductor canal regional block.

multimodal pain approach is now an accepted standard of care to improve pain, enable earlier mobilization and faster recovery, decreased length of stay, and reduce opioid consumption and related side effects. the multimodal approach includes peri-operative oral and iv analgesics, local periarticular injections (pai), and/or regional blocks such as femoral nerve blocks nerve or subsartorial saphenous nerve (adductor canal) blocks. extended release bupivacaine (exparel - pacira pharmaceuticals, parsippany, nj, usa) in liposomal form was developed for longer lasting post-operative analgesia. there are limited studies analyzing its efficacy of single injection liposomal bupivacaine in adductor canal block in total knee arthroplasty. the investigators hypothesized that a single adductor canal regional block injection would provide similar pain relief as peri-articular infiltration of exparel.

Eligibility criteria:
inclusion criteria: * primary knee osteoarthritis undergoing unilateral knee replacement exclusion criteria: * hypersensitivity and/or allergies to local anesthetics or previous knee surgery

Keywords: liposomal bupivacaine total knee arthroplasty
early-onset rectal cancer

Conditions: Rectal Cancer

Summary: the present study aimed to review the characteristics and outcome of early-onset rectal cancer in a subset of egyptian patients aged 40 years or less. since the previous studies assessed this point of research in crc overall, the investigators opted to focus upon rectal cancer alone since it may represent a separate category, distinct from colon cancer, in this age group with regards to presentation, tumor behavior, and outcome.


Eligibility criteria:
inclusion criteria: * patients of either gender aged 40 years or less who presented with rectal cancer of any stage were included to the study exclusion criteria: * patients with colon cancer or other gastrointestinal cancer and patients who were lost to follow-up.
bone healing at implants installed in sites prepared either with a sonic device or drills

Conditions: Alveolar Bone Loss

Summary: the purpose was to evaluate histomorphometrically the early healing at implants installed in sites prepared with either a sonic device or conventional drills.

sixteen volunteer patients will be recruited. two titanium mini-implants will be installed in the distal segments of the maxilla in recipient sites prepared with either a sonic device or conventional drills. biopsies containing the mini-implants will be retrieved after 2 weeks in eight patients, and after 6 weeks in the other eight patients. histomorphometric analyses will be performed

Eligibility criteria:
inclusion criteria: * presence of an edentulous atrophic zone in the posterior segment of the maxilla * height of the sinus floor ≥10 mm * ≥ 25 years of age; * smoking ≤10 cigarettes per day * good general health * no contraindication for oral surgical procedures * not being pregnant. exclusion criteria: * presence of systemic disorders * chemotherapy or radiotherapy * smokers \>10 cigarettes per day * previous bone augmentation procedures in the same region.
a study of ono-1110 in patients with social anxiety disorder

Conditions: Social Anxiety Disorder (SAD)

Summary: to evaluate the efficacy and safety of ono-1110 in patients with social anxiety disorder


Eligibility criteria:
inclusion criteria: 1. japanese participants (sex not specified) 2. participants who, in the opinion of the principal (or sub-investigator), are capable of understanding the content of the clinical trial and complying with its requirements 3. participants diagnosed with social anxiety disorder based on dsm-5-tr (diagnostic and statistical manual of mental disorders, fifth edition, text revision) criteria, as determined through an interview using the m.i.n.i. (mini-international neuropsychiatric interview) 4. outpatients 5. participants with a lsas-j (liebowitz social anxiety scale japanese version) total score of 70 or higher and a cgi-s (clinical global impression-severity) score of 4 or higher exclusion criteria: 1. participants with a current or past history of psychiatric or neurological disorders that meet any of the following criteria: * participants with a comorbid psychiatric disorder other than social anxiety disorder as defined by dsm-5-tr (diagnostic and statistical manual of mental disorders, fifth edition, text revision) (assessed using the m.i.n.i. (mini-international neuropsychiatric interview)) * participants with a comorbid or past history of schizophrenia or other psychotic disorders as defined by dsm-5-tr (diagnostic and statistical manual of mental disorders, fifth edition, text revision) * participants with neurodevelopmental disorders, neurocognitive disorders, or personality disorders (excluding avoidant personality disorder) as defined by dsm-5-tr 2. participants who have been primarily diagnosed with a disorder other than social anxiety disorder according to dsm-5-tr (diagnostic and statistical manual of mental disorders, fifth edition, text revision) criteria within 24 weeks prior to screening 3. participants with a madrs (montgomery åsberg depression rating scale) total score of 15 or higher 4. participants who, in the opinion of the principal (or sub-investigator), have not responded to at least two different ssris (selective serotonin reuptake inhibitor), each administered at an adequate dose for at least 10 weeks, in treating social anxiety disorder
noninvasive physiologic sensors to assess depression

Conditions: Depression; Major Depressive Disorder

Summary: this project aims to use sensors to monitor physiological signals, sleep patterns, vocal characteristics, activity, location and phone usage in study patients with depression who are receiving standard treatment (compared with healthy controls).


Eligibility criteria:
inclusion criteria: patients with depression (n=40): 1. adults (ages 18-75), 2. able to read, understand, and provide written informed consent in english, 3. meet criteria for a primary psychiatric diagnosis of major depressive disorder for ≥ 4 weeks, according to the m.i.n.i (mini international neuropsychiatric interview), 4. hamilton depression rating scale (hdrs) total score ≥ 18, 5. engaged in or willing to be referred for clinical care for depression treatment as usual (antidepressants and/or psychotherapy), 6. must have measurable skin conductance/electrodermal activity (as assessed at the screening visit), 7. must own a working android smartphone (android 2.3+) and use it regularly, 8. must own a windows pc (or tablet) or a mac computer (or laptop), 9. must have access to internet service every day. healthy controls (n=10): 1. adults (ages 18-75), 2. able to read, understand, and provide written informed consent in english, 3. not meet criteria for past or current psychiatric illness, excluding specific phobias, as measured by the m.i.n.i., 4. not have a first-degree relative with known major psychiatric illness including major depressive disorder, bipolar disorder, psychotic disorder or substance use disorder, 5. must have measurable skin conductance/electrodermal activity (as assessed at the screening visit), 6. must own a working android smartphone (android 2.3+) and use it regularly, 7. must own a windows pc (or tablet) or a mac computer (or laptop), 8. must have access to internet service every day. exclusion criteria (for all subjects): 1. active drug or alcohol use disorder in the past 3 months, 2. history of psychosis, 3. history of mania or hypomania, 4. epilepsy or history of seizures, 5. untreated hypothyroidism, 6. unstable medical disease, 7. cognitive impairment that would impede adherence to study procedures, 8. acute suicide or homicide risk, 9. current treatment with electroconvulsive therapy, vagal nerve stimulation therapy, deep brain stimulation, transcranial magnetic stimulation therapy, or phototherapy, 10. concurrent participation in other research studies, 11. cannot comprehend or communicate in english, 12. lack of working smartphone or lack of daily access to internet service, 13. inability to measure skin conductance/electrodermal activity (as assessed at the screening visit), and 14. inability or unwilling to, at minimum, wear the physiological sensor (e4) bands, fill out the surveys, and record a weekly diary.
children's health research institute(chri), stanford lucile packard children hospital (lpch) protocol on myotonic dystrophy

Conditions: Myotonic Dystrophy Type 1

Summary: study to focus on the defining and managing the neuropsychological abnormalities of myotonic dystrophy and to find out if the neuropsychological abnormalities have any correlation with changes seen on magnetic resonance imaging.

given the prevalence of dm, and assistance from the myotonic dystrophy foundation (letter), we anticipate full recruitment of 8-17 year old subjects with dm1. the genetic counselor will help recruit 20 dm1 subjects, and 20 comparably aged controls, all of whom will complete mri and neuropsychological tests. we anticipate full participation in evoked potential and blood tests, but estimate 30% will permit a lumbar puncture for csf evaluation - done at the lpch ambulatory procedure unit with sedation as necessary. in total 40 mris will be done over 2 years, or 20 annually. testing of subjects all neuropsychological evaluations will be performed in the morning in attempt to standardize wakefulness and stamina. dr. day's assessment of clinical status (\~45 min) utilizes the stanford myotonic dystrophy questionnaire, the university of rochester mdhi, and the muscular impairment rating scale (mirs)57, and records vital signs, current medications, spirometer, and disease history and progression. given the frequency of sleep disorders in dm, subjects will complete the affiliated sleep questionnaire, an online collection of extensive information in standardized format (see letter dr. mignot). after the clinical and neuropsychological assessments the subject and family members will have lunch prior to the mri(75 min). in the mid-afternoon subjects will have evoked potentials in the electrodiagnostics lab(\~90 min) followed by a lumbar puncture (if consenting) and blood draw in the lpch apu(90 min). subjects return home the same day, and ms. paulose contacts them several days later for feedback.

Eligibility criteria:
inclusion criteria: * 20 subjects with myotonic dystrophy type 1 aged 8 to 17 years and 20 controls who are healthy volunteers or siblings of affected subjects. exclusion criteria: -
the impact of perceptual impairment on social participation in stroke patients

Conditions: Cerebrovascular Accidents

Summary: the perceptual change on stroke patients during the movement recovery and its relationship with social participation still remain unclear. the purposes of this study are: 1) to observe the progression of perception deficit and 2) to understand the relationships among perception deficit and other functional indicators. a total of 90 stroke patients will be recruited. each patient will receive three times evaluation, including perception tests, motor function test, daily living ability tests and social leisure participation questionnaires.

according to motor control theory, perception plays an important role in the execution of motion. although the effect of rehabilitation for motor recovery on stroke patients has been well established, the perceptual change during the movement recovery and its relationship with social participation still remain unclear. a total of 90 stroke patients will be recruited. each patient will receive initial evaluation, first follow-up evaluation after four weeks and second follow-up evaluation after five months. the contents include basic clinical screen tests, perception tests, motor function test, daily living ability tests and social leisure participation questionnaires. the purposes of this study are: 1) to observe the change of the during the experiment and clarify the progression of perception deficit and 2) to understand the relationships among perception deficit and the other functional indicators and determine the impact of perception deficit on activities and participation in stroke patients.

Eligibility criteria:
inclusion criteria: * the age over 40 years old * the time of onset more than 3 months * no cognitive dysfunction * cerebral stroke * clinical diagnosis of a first or recurrent unilateral stroke exclusion criteria: * recurrent of the stroke or epilepsy during the intervention * patients with the neurological or psychical history, for example, alcoholism, drug poisoning or bipolar disorder * participate in the other interventional study in the same time * refuse subscribed the informed consent

Keywords: stroke rehabilitation perceptual deficits
covid-19 antigen rapid test kit

Conditions: SARS-CoV2 Infection

Summary: the sg diagnostics covid-19 antigen rapid test kit (colloidal gold-based) is a single-use test kit intended to detect the novel coronavirus sars-cov-2 that causes covid-19. this test is intended for use with self-collected nasal swab samples in individuals who are suspected of covid-19. this test utilizes a lateral flow immunoassay technology for the qualitative detection of spike and nucleocapsid protein antigens of sars-cov-2 in individuals with known or suspected covid-19.


Eligibility criteria:
inclusion criteria: * adult (aged ≥ 18 years) volunteers exclusion criteria: * children (aged \< 18years)

Keywords: sars-cov-2 covid-19 symptoms test