Kornimate/medical-research-clean huggingface dataset:
transcutaneous electrical nerve stimulation for pain relief during the active phase of labor

Conditions: Pain

Summary: the objective of this research is to evaluate the effectiveness of transcutaneous electrical nerve stimulation (tens) for pain relief in the early active phase of labor. the research will be of type randomized controlled trial, consisting of low-risk nulliparous pregnant women admitted to the reference center for women's health in ribeirão preto. mothers will be divided into two groups (the use of lumbosacral tens) and control (routine maternity) and will be evaluated before and after therapy, which corresponds to 30 minutes between 4-5 cm of cervical dilation. the evaluation will be performed by numerical category scale, location and pain diagram mcgll pain questionnaire (short form). after the delivery will be a questionnaire of customer satisfaction.

pain in the work appears as a subjective experience of interaction, involving a wide individual influences physiological, psychosocial and environmental factors, representing a major clinical signs of this phase. despite presenting an important biological function, is now well established the need for their relief, since its persistence is associated with detrimental effects for both mother and fetus. among non-pharmacological resources available, the investigators highlight the massage therapy that has shown positive effects in relieving pain and promote comfort of the mother. the objective of this research is to evaluate the efficacy of transcutaneous electrical nerve stimulation (tens) for pain relief in the early active phase of labor. the research will be of type randomized controlled trial, consisting of low-risk nulliparous pregnant women admitted to the reference center for women's health in ribeirão preto. mothers will be divided into two groups (lumbosacral massage) and control (routine maternity) and will be evaluated before and after therapy, which corresponds to 30 minutes between 4-5 cm of cervical dilation. the evaluation will be performed by numerical category scale, location and pain diagram mcgll pain questionnaire (short form). after the delivery will be a questionnaire of customer satisfaction. after collecting the data, the groups are statistically analyzed using the linear regression model with mixed effects (fixed and random), taking into account a value of p \<0.05 for statistical significance of 5%.

Eligibility criteria:
inclusion criteria: * primigravida * literate * a single fetus in vertex position * low-risk pregnancy * from 37 weeks of gestation * cervical dilatation between 4 and 5 cm with uterine dynamics normal for this stage * labor in early spontaneous * no use of medications during the study period * absence of cognitive or psychiatric problems * intact membranes * no risk factors associated * who wish to participate and signed the informed consent exclusion criteria: * tens procedure intolerance * use of any medication or procedure that promotes pain relief * use of pacemaker

Keywords: pain electric stimulation nervous transcutaneous humanized childbirth
human bronchial microdialysis in open aortic aneurysm repair

Conditions: Acute Lung Injury

Summary: elective open aortic aneurysm repair has an overall reported 30 day mortality of 2-6 percent, but in patients more than 65-70 years the mortality is reported to be more than 10 percent. the phenomenon of acute lung injury (ali)/adult respiratory distress syndrome (ards) after infra renal abdominal aneurysm repair caused by ischemia-reperfusion is well established. the degree of disability varies from a light degree of acute respiratory failure to mortality for patients with the same profile of risk. primary aim is to develop a model that monitors inflammatory marker molecules collected from the bronchial epithelial lining fluid by microdialysis. the method with examination of the bronchial epithelial lining fluid by microdialysis and analysis of multiple inflammation markers as previously done by the investigators group.


Eligibility criteria:
inclusion criteria: * patients assigned for elective open aortic surgery exclusion criteria: * moderate to severe copd
immunogenicity and safety of covid-19 vaccine in cancer patients

Conditions: Cancer; Covid19

Summary: serum antibody titre against covid-19 spike protein will be measured before, after the first dose, and after the second dose (when applicable) in cancer patients who are receiving or received anti-cancer drugs. side effects of vaccination and actual incidence of covid-19 will be monitored.


Eligibility criteria:
inclusion criteria: * 20 years of age or older * patients who are receiving or received anti-cancer drugs * those who are not vaccinated against covid-19 at the time of enrollment * written informed consent exclusion criteria: * any contraindications to covid-19 vaccines * those who were already vaccinated * those who are on immunosuppressants or infected with hiv * those who underwent organ transplantation * active infections (for example, pneumonia)
remote information counseling for elders

Conditions: Obesity

Summary: the purpose of this study is to provide testing methods of delivering nutrition and physical activity services for weight loss.


Eligibility criteria:
inclusion criteria: 1. aged 40 to 64 years. 2. one or more chc visits in the past 12 months. 3. body-mass index of ≥30 and \<50. 4. english speaking. 5. access to telephone. 6. a permanent address. 7. willingness to be randomized. 8. willingness to have computer installed in home. exclusion criteria: 1. any serious medical condition likely to hinder accurate weight measurement, or for which weight loss is contraindicated or could cause weight loss (e.g., cancer). 2. current diagnosis of psychosis or bipolar disorder. 3. unstable or recent onset of cardiovascular disease within 6 months or presence of congestive heart failure 4. illness that might be associated with weight change, such as asthma (because of treatment with corticosteroids), psychosis 5. use of medications that might cause weight gain such as hypoglycemic oral medicines or insulin, anti-depressants, and weight loss medications. 6. unwilling or unable to provide informed consent. 7. receiving disability insurance. 8. pregnant or nursing in past 6 months, or plans to become pregnant within 12 months. 9. enrolled in a weight loss program or study or member of household enrolled in study. 10. residence outside of marion county, indiana. 11. residence relocation plans within 12 months. 12. planned or prior bariatric surgery. 13. substance abuse. 14. history of treatment for eating disorder. 15. unstable weight with loss or gain of ≥ 5% in last 3 months. -
the clinical validity and safety of iop injection mri contrast agent in hepatocellular carcinoma

Conditions: Magnetic Resonance Imaging

Summary: this study is an exploratory study aiming to collect data on sensitivity and positive predictive value of iop-enhanced (mpb-1523) mri compared to dynamic multiphase mdct for the detection of hcc.

the planned duration of the clinical study for individual subjects is up to 12 weeks.

Eligibility criteria:
inclusion criteria: 1. subjects ≥18 years of age 2. patients with suspected hcc scheduled for partial hepatic resection. 3. presenting with 1 to a maximum of 5 hepatic nodule(s) of equal or more than 1 cm (long axis) previously identified and characterized through multi-phase contrast enhanced ct. 4. subjects or their partners must use a highly effective method of contraception starting from at least one menstrual cycle prior to starting study drug and till 30 days after the last dose of study drug. exclusion criteria: 1. subjects who received any previous treatment for hcc. 2. subjects with a serious allergic history or known allergy of other contrast agent. 3. subjects with a positive hiv test. 4. subjects with severe renal insufficiency 5. subjects with severe liver disease\[hcv\]. 6. subjects with active systemic infections, active and clinically significant cardiac diseases, active gastrointestinal ulcers, or medical conditions that may significantly affect action, adequate absorption, and elimination of investigational contrast agent. 7. subject with mechanically, electrically or magnetically-activated implanted device or any metal in their body which cannot be removed. 8. subjects who have participated in other investigational trials within 30 days prior to study enrollment. 9. female subjects who are pregnant or breastfeeding. 10. subjects who are clinically unstable and whose clinical course during the screening period is unpredictable.

Keywords: hepatocellular carcinoma magnetic resonance imaging
comparison of safety and efficacy of tocosol(r) paclitaxel versus taxol(r) for treatment of metastatic breast cancer

Conditions: Breast Neoplasm

Summary: the purpose of this study is to compare the objective response rates of patients randomized to receive either tocosol(r) paclitaxel or taxol(r) (paclitaxel injection) administered every week to patients with metastatic breast cancer. the study hypothesis is that the objective response rate with tocosol paclitaxel given every week is non-inferior to that observed with taxol given every week.

female patients with first or second line metastatic breast cancer will be randomized to receive either weekly tocosol paclitaxel or weekly taxol (paclitaxel injection). patients will undergo radiographic imaging of their disease to assess response to therapy. the primary endpoint of this study is a comparison of the objective response rates observed in patients receiving tocosol paclitaxel, to those receiving taxol. time-to-disease progression and overall survival will also be compared. the toxicities of the two treatment regimens will be compared.

Eligibility criteria:
inclusion criteria: * patients with histologic diagnosis of breast carcinoma * stage iv (m1) disease * adult (18 years of age or older) patients exclusion criteria: * patients treated with a taxane within the past year * patients whose tumor tissue is known to show over expression of her2/neu

Keywords: metastatic breast cancer
minimal access repair of contralateral hernias (march trial)

Conditions: Unilateral Inguinal Hernia

Summary: repair of unilateral inguinal hernia in infants. laparoscopic repair, with closure of contralateral patent processus vaginalis if present, versus open repair


Eligibility criteria:
inclusion criteria: * unilateral inguinal hernia exclusion criteria: -
postoperative neurocognitive dysfunction: is there any place for emergency agitation: a prospective cohort trial

Conditions: Emergence Delirium; Emergence Agitation; Postoperative Delirium

Summary: perioperative neurocognitive disorders (pnd) have been studying by clinicians, particularly by anesthesiologists, pretty long, however the most inspiring advancements were achieved during the last few decades. the most recent classification of pnd which includes cognitive decline diagnosed before operation (described as neurocognitive disorder); any form of acute event (postoperative delirium) and cognitive decline diagnosed up to 30 days after the procedure (delayed neurocognitive recovery) and up to 12 months (postoperative neurocognitive disorder) was proposed in 2017. however at will one can notice at least one uncertainty that pertinent to the definition of delirium, emergency delirium and not mentioned in the classification discussed agitation. the objective of the study is to determine if there is a difference between emergence agitation and emergence delirium.


Eligibility criteria:
inclusion criteria: * age from 45 to 74 years * undergoing elective orthopedic surgery * provide written informed consent to participate in the pod trial exclusion criteria: * undergoing emergent/urgent surgery * montreal cognitive assessment \< 18 points * history of mental disorders according icd-11 * treated with at least one psychotropic drug * patients with neuromuscular disease * inability to undergo preoperative assessment for any reason * previously enrolled in pod trial

Keywords: emergence agitation postoperative agitation postoperative delirium postoperative cognitive dysfunction emergence delirium
a pilot study of minocycline in intracerebral hemorrhage patients

Conditions: Intracerebral Hemorrhage

Summary: the mach trial is a pilot study of 400mg minocycline over five days in acute intracerebral hemorrhage patients. the study will evaluation the safety and efficacy of minocycline in intracerebral hemorrhage patients.

mach is a randomized trial of minocycline in intracerebral hemorrhage. 24 total subjects will be randomly assigned to minocycline or control (1:1). the first dose will be given intravenously. subsequent doses will be given orally every 24 hours for a total of five doses. the study will test to see if the medication is safe in intracerebral hemorrhage. the pharmacokinetics of minocycline in intracerebral hemorrhage will be determined and the impact of minocycline on blood biomarkers.

Eligibility criteria:
inclusion criteria: * 18 years of age or older. * intracerebral hemorrhage documented by ct scan * the first dose of the drug can be administered within 12 hours of time last known to be at baseline exclusion criteria: * allergy to tetracycline antibiotics * pregnancy or suspected pregnancy (pregnancy test will be done on women of child-bearing potential) * hepatic and/or renal insufficiency (lft's \>3x upper limit of normal; creatinine \>2mg/dl) * history of intolerance to minocycline * national institutes of health stroke scale score of 4 or less * glasgow coma scale score of 5 or less * surgical evacuation of hematoma planned within 24 hours * secondary intracerebral hemorrhage resulting from trauma, arteriovenous malformation, aneurysm, tumor or other causes * thrombocytopenia (platelet count \ 1.4) * previously not independent (prestroke modified rankin scale score \>2) * suspected of not being able to comply with the study protocol * unlikely to be available for 90 day follow-up * pre-existing do not resuscitate (dnr) order or indication that a new dnr order will be implemented within the first 48 hours of hospitalization

Keywords: stroke acute intracerebral hemorrhage intracerebral hemorrhage hemorrhagic stroke hemorrhage minocycline
a survey on low blod sugar among insulin-treated patients with diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: this study is conducted globally. the aim of this study is to describe the proportion of patients with hypoglycaemic episodes and estimate the incidence of various types of hypoglycaemia in the retrospective and prospective periods.


Eligibility criteria:
inclusion criteria: * informed consent obtained before any trial-related activities * patient with t1dm or t2dm treated with insulin for more than 12 months * male or female patient at least 18 years of age at the time of inclusion in the study exclusion criteria: * previous participation in this study * mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation * illiterate patients and patients otherwise unable to sign the informed consent or complete a written survey * non-ambulatory patients * simultaneous participation in any other clinical study with an investigational product
methylphenidate effect on humphrey visual fields

Conditions: Visual Field Tests

Summary: study will include adults with abnormal visual fields. half of them will be given either methylphenidate 10mg 2 hours before repeating the visual field test. the rest will serve as controls. all subjects will also have a complete eye examination, a short questionnaire and a questionnaire to screen for attention deficit disorder. the investigators will compare the visual field results between the 2 tests.

healthy adults with abnormal visual fields will be offered to participate subjects will have a complete ophthalmic examination including dilated fundus examination. subjects with clear explanation for a visual field defect (e.g. optic neuropathy or retinal disorder) will be excluded from the study the subjects will be randomly assigned to the study group and control group using a 1:1 allocation. subjects in the study group will be provided with a single tablet of methylphenidate 10 mg to be taken orally 2 hours before repeating their visual field test. the control group will not receive any placebo both groups will repeat their visual fields. both groups will fill out a short questionnaire to evaluate their experience in the second visual field test. the study group will also fill out a screening questionnaire to rule out previously undiagnosed attention deficit disorder. two experienced ophthalmologists will separately interpret the visual fields results and compare the first and second visual fields of each subject, while being blinded to which group he was in. subjects will be provided with their test results and the ophthalmologist interpretation.

Eligibility criteria:
inclusion criteria: * abnormal visual fields * must be able to swallow pills exclusion criteria: * psychiatric disorder * dementia * ocular disorder which is known to cause abnormal visual fields * prescription of psychoactive medications * visual acuity lower than 20/100 * cardiac arrhythmia * hypersensitivity to methylphenidate * prescription of warfarin

Keywords: humphrey visual fields methylphenidate attention deficit disorder moca questionnaire
quantitative mri for myelofibrosis

Conditions: Myelofibrosis

Summary: this study is for the development and validation of functional magnetic resonance imaging (mri) parameters as biomarkers for analyzing extent of disease and quantifying response to treatment in patients with myelofibrosis.

this study is for the development and validation of functional magnetic resonance imaging (mri) parameters as biomarkers for analyzing extent of disease and quantifying response to treatment in patients with myelofibrosis. quantitative mri parameters for diffusion of water and/or fat content in bone marrow will determine extent of disease in patients with myelofibrosis, and changes in these parameters will predict response to therapy. to investigate this hypothesis, the researchers will perform this pilot clinical study of diffusion and fat content (t1 weighted imaging) in patients before and during treatment for myelofibrosis. the researchers expect to identify mri parameters that determine the extent and severity of bone marrow disease in these patients and determine response to therapy at earlier time points than currently used clinical parameters. this research will lay the foundation for larger clinical trials using mri to assess and predict effects of existing and new therapeutic agents for patients with myelofibrosis. this study proposes that more advanced mri techniques currently used in clinical medicine can be applied to enable response to therapy to be determined earlier than currently is possible for patients with myelofibrosis. in particular, this study is designed to determine to what extent abnormalities in diffusion of water molecules (diffusion mri) and/or fat content in bone marrow (t1-weighted imaging) define extent of initial disease and serve as early predictors of response to therapy.

Eligibility criteria:
inclusion criteria: 1. male /female subjects over the age of 18 2. diagnosis of primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocythemia myelofibrosis. 3. no contraindications to mri 4. able to undergo mri without anesthesia - exclusion criteria: 1. patients with pacemakers or other implanted magnetic devices that may malfunction or move because of the strong magnetic field inside the mri room and scanner. 2. any prior adverse event associated with mri that is not related to injection of contrast agents or other medicines. -
intervention to enable stroke survivors in los angeles county hospitals to "stay within the guidelines"

Conditions: Stroke

Summary: the purpose of this study is to test a newly developed outpatient care intervention called sustain (systematic use of stroke averting interventions) for improving delivery of stroke preventive services at los angeles county hospitals and to measure the costs of running such an intervention.

patients randomized to sustain will participate in group clinics about stroke, given self-management tools about stroke, and will be called by nurse practitioners to coordinate their stroke care. patients randomized to the control arm will be mailed educational materials about stroke. subjects in either arm are eligible to receive their usual source of care.

Eligibility criteria:
inclusion criteria: * patients of lac+usc, rancho los amigos, olive view-ucla, or harbor-ucla * patients who have had an acute transient ischemic attack (tia) or ischemic stroke or carotid procedure within the last six months * english or spanish speaking * at least 40 years of age * capable of giving informed consent (no proxies will be used to obtain consent) * blood pressure not optimally controlled (\>120/80, at least 72 hours post-stroke) exclusion criteria: * age 39 years or younger * hemorrhagic stroke * patients with severe global disability which would preclude him/her from participating in group clinics * patients with advanced dementia

Keywords: group clinics self management
ultrasound for guidewire detection

Conditions: Kidney Failure, Acute; Kidney Failure, Chronic

Summary: the aim of the project is to check if there is a possibility for a nephrologist to visualise the guidewire by means of available ultrasound scanners. to evaluate that, the procedure of catheter insertion will be expanded by ultrasound examination of right atrium and inferior vena cava border using substernal view. such imaging seems to ameliorate the safety of catheter implementation and could be a good alternative for fluoroscopy, eliminating its adverse effects.


Eligibility criteria:
inclusion criteria: * renal failure requiring hemodialysis through a dialysis catheter * capable of giving informed consent * placement of internal jugular vein catheter exclusion criteria: * inability to provide informed consent * poor visualisation of inferior vena cava

Keywords: hemodialysis vascular access dialysis catheter