Kornimate/medical-research-clean huggingface dataset:
patient comfort using green vs. yellow pan retinal photocoagulation

Conditions: Proliferative Diabetic Retinopathy - High Risk

Summary: our aim is to compare patient comfort when using the 532 nanometer (green) wavelength laser to the 577 nanometer (yellow) wavelength laser during pan retinal photocoagulation to treat patients with diabetic retinopathy. secondary outcome measures will be power (mw) required to achieve gray-white retinal burns and duration of treatment.

as demonstrated in the diabetic retinopathy study (drs), panretinal photocoagulation (prp) reduces the risk of severe vision loss in patients with proliferative diabetic retinopathy. the drs recommended that prp treatment consist of 1,200 - 1,600 laser burns 500 µm in size, one half to one burn width apart, applied to the peripheral retina in a scatter fashion. most patients who undergo prp experience discomfort/pain during the procedure. once present, pain can affect the number and quality of burns delivered and can indirectly increase the number of sessions required to complete the therapy.this may in turn adversely affect patient compliance. although retrobulbar and peribulbar blocks can provide adequate anesthesia for prp, these anesthetic methods carry rare but serious risks such as retrobulbar hemorrhage. previous studies have explored other ways to reduce discomfort related to prp, including optimization of laser settings, oral and topical analgesics, subconjunctival anesthesia, and even acupuncture. currently, green lasers (521 - 532 nm wavelength) are most commonly utilized for performing prp in clinical practice. yellow lasers (577 nm wavelength) have been of recent interest in treating diabetic macular edema with micropulse subthreshold grid photocoagulation, but have not been extensively studied in prp for diabetic retinopathy. compared to shorter wavelength laser, yellow laser comports high transmission through dense ocular media and less light scattering than shorter wavelengths which minimizes spot size and reduces thermal spread. the limited literature comparing green and yellow laser for prp in diabetic retinopathy has shown that yellow laser requires less power to achieve a retinal burn. in theory this should translate into a reduction in perceived pain experienced during prp, however a comparison of green and yellow lasers in this regard has not yet been directly examined and quantified.

Eligibility criteria:
inclusion criteria: * patient of wills eye hospital retina service and/or mid atlantic retina * volunteer patients age 18 years and older. * healthy enough to participate in the study. * willing and able to consent to participation in the study. * diagnosis of pdr with hrc based on clinical criteria outlined by the drs. exclusion criteria: * patient less than 18 years of age * institutionalized patient * prisoner * significant media opacity obscuring a view of the superior retina * history of intra-ocular surgery except cataract surgery * history of prp laser within the last 30 days
ds-9231 in intermediate-risk (sub-massive) acute pulmonary embolism (pe)

Conditions: Pulmonary Embolism

Summary: the primary objective of this study is to evaluate safety and initial effectiveness of ds-9231 when taken together with current standard of care. evaluation will be done with low, medium and then high doses of ds-9231 versus placebo, in participants with medium-risk acute pulmonary embolism.


Eligibility criteria:
inclusion criteria: * had protocol-defined pulmonary embolism (pe) * has stable systolic blood pressure (sbp) \>90 mm hg * has evidence of right ventricular (rv) dysfunction * has executed informed consent exclusion criteria: * has history or plans for thrombotic therapy outside protocol allowance * has other contraindications for participation * has laboratory results outside protocol-specified limits * is pregnant, nursing, and/or not willing or able to use protocol-defined contraceptives * has history or condition, or participated in another investigational study that (per protocol or in the opinion of the investigator) might compromise: 1. the safety or well-being of the participant or the participant's offspring 2. the safety of study staff 3. the analysis of results

Keywords: sub-massive acute pulmonary embolism
food-based solutions for optimal vitamin d nutrition and health

Conditions: Vitamin D Deficiency

Summary: this project aims at proving the efficacy and safety of food based solutions to prevent vitamin d deficiency in high risk populations of caucasian and south asian origin living in denmark.

the study is a 12 week double-blinded, randomised, placebo-controlled food-based intervention trial in a real-life setting. 140 (18-50 y) women in risk of vitamin d deficiency and with caucasian or south asian origin. the two ethnic groups of women will each be randomised into two groups. one receiving vitamin d fortified foods and the other receiving the same kind of foods non-fortified. foods given in the study period are free of charge for the participants and will be handed out every second week. the foods are eggs, yoghurt, cheese and crisp bread. the study includes a baseline visit and a final visit, at both visits blood samples will be drawn, anthropometrics, muscle strengths, dietary and background questionnaires.

Eligibility criteria:
inclusion criteria: * 18-50 year old women * low consumption of fish and fish products * low intake of vitamin d containing supplements * no use of sunning facilities * no planned sun-holiday between october 2015 and may 2016 exclusion criteria: * pregnancy and breastfeeding * menopause * serious diseases (cancer, server liver or kidney insufficiencies, sarcoidosis and other granulomatous diseases) and medicines affecting the vitamin d metabolism (steroids, antiepileptic, thyroid hormones, bisphosphonates, oestrogen).

Keywords: vitamin d fortification
adaptation to ozone in individuals with asthma/exercise-induced bronchoconstriction

Conditions: Asthma; Asthma, Exercise-Induced; Exercise Induced Asthma; Exercise Induced Bronchospasm

Summary: researchers found that impairments in the cardiopulmonary system caused by acute exposure to ozone were outweighed by repeated exposures to ozone. the goal of this study is to confirm there will be an adaptation similar to what was previously proved but in individuals with asthma and exercise-induced bronchoconstriction (eib). the purpose is to examine adaptive responses in a randomized cross-over trial in which physically active individuals will perform submaximal exercise on five days in ozone and filtered air exposures separated by a washout period.


Eligibility criteria:
inclusion criteria: * recreationally active individuals * diagnosed asthma and/or mild exercise-induced bronchoconstriction: defined by an fev1 fall equal to or greater than 10% but lower than 25% in the eucapnic hyperventilatory test. * able to securely perform a maximal exercise test (responded 'no' to all questions on the par-q+ questionnaire) * able to communicate in english exclusion criteria: * diagnosed with any cardiorespiratory or vascular diseases * pregnant or potentially pregnant * non-smoking * lower limb musculoskeletal injury or lower limb limitation to cycle on a bicycle ergometer * recent respiratory symptoms or upper tract infection within 4 weeks * on vitamin (e.g., c or e) supplementation

Keywords: ozone air pollution asthma exercise-induced bronchoconstriction
mild hypofractionation with proton therapy or intensity modulated radiation therapy (imrt) for intermediate-risk prostate cancer

Conditions: Prostate Adenocarcinoma

Summary: this is a study to first establish feasibility of the study and then to register the treatment data of adult patients with a diagnosis of intermediate risk of prostate cancer presenting for definitive radiation treatment with either proton radiotherapy or intensity modulated radiation therapy (imrt). the investigators propose to employ a hypofractionated strategy with our image guided treatment to further improve cancer control and decrease toxicity.

this study will be done in two phases, first, a feasibility study and then a registration study. in the first, feasibility will be established using the primary objectives set below. the second phase will begin no earlier than 30 days after the last patient in the initial phase has completed treatment and once safety and feasibility has been verified. the secondary objectives will serve as the objectives for the second phase of the study.

Eligibility criteria:
inclusion criteria * histologically confirmed prostate adenocarcinoma within 365 days of registration. * clinical stages t1a-t2c n0 m0 (ajcc criteria 6th ed). for any suspicious pelvic lymph node \> 1.5cm (as exhibited on pelvic imaging), biopsy of the lymph node is suggested. * histological evaluation of prostate biopsy with assignment of a gleason score to the biopsy material; gleason score must be in the range 2-7. biopsy with \> 6 cores is strongly recommended. (the highest gleason score in any core reported on the pathology report will be used for determining inclusion.) * psa values \<20 ng/ml within 90 days prior to registration, and done either prior to prostate biopsy, or at least 21 days after prostate biopsy. * zubrod (ecog) status 0-1 documented within 90 days of registration. * androgen deprivation is at the discretion of the treating radiation oncologist. * subjects must give irb-approved study-specific informed consent. subjects must complete all required tests within the specified time frames. * subjects must be at least 18 years old. * members of all races and ethnic groups are eligible for this trial. exclusion criteria * clinical stages t3 or greater (ajcc criteria 6th ed). * psa of 20 ng/ml or greater. * gleason score 8 or higher. * evidence of distant metastasis. (determined by ct scan, mri, and/or bone scan prior to the simulation appointment; imaging results from uphs will supercede results from similar scans from an outside facility.) * evidence of lymph node involvement. * previous prostate cancer surgery to include: prostatectomy, hyperthermia, and cryosurgery. * previous pelvic radiation for prostate cancer. * active rectal diverticulitis, crohn's disease, or ulcerative colitis. * prior systemic chemotherapy for prostate cancer. * history of proximal urethral stricture requiring dilatation.

Keywords: adult histologically confirmed
breast cancer and chemo-amennorhea

Conditions: Breast Cancer

Summary: relation between chemotherapy and amennorhea


Eligibility criteria:
inclusion criteria: pre-menauposal breast cancer needed to be treat with chemotherapy - exclusion criteria: metastases menopausal -

Keywords: pre-menauposal neo-adjuvant or adjuvant chemotherapy no metastases
physical activity and cerebral metabolism in the elderly: a randomised controlled trial

Conditions: Dementia; Cognitive Impairment

Summary: physical activity exerts a variety of long-term health benefits in older adults.this randomised controlled trial investigates the effect of a 12-week physical exercise program on the change in cerebral metabolism as assessed with magnetic resonance spectroscopic imaging. follow-up lasts for 6 months.


Eligibility criteria:
inclusion criteria: 1. be above 65 years of age, 2. voluntariness 3. capacity to consent, 4. having passed medical entry exam by the department of sports medicine, 4) regular mental capacity, 5) written informed consent exclusion criteria: 1. untreated clotting disorders, 2. musculoskeletal diseases significantly reducing mobility, 3. severe bacterial or viral infections, 4. severe respiratory diseases (gold iv), 5. acute pulmonary embolism, 6. instable angina pectoris or severe heart failure (nyha iii or iv), 7. severe vascular disease of the extremities or the brain, 8. severe pulmonary-cardiac dysfunction, 9. acute myocardial infarction or early phase of rehabilitation, 10. critical aortal stenosis, 11. severe hypertrophic and obstructive cardiomyopathy, 12. untreated malignant arrhythmias, 13. untreated severe hypertonia, 14. severe pulmonary hypertonia, 15. symptomatic cardiac malformations, 16. cardiac-block grade ii or iii, 17. left bundle branch block, 18. complex ventricular arrhythmias, 19. cognitive impairment

Keywords: aerobic exercise training prevention magnetic resonance spectroscopic imaging psychometric tests cognition dementia cognitive impairment
treatment of nasal staphylococcus aureus colonization in patients with hht

Conditions: Hereditary Hemorrhagic Telangiectasia; Epistaxis

Summary: compare the frequency of epistaxis and quality of life related to nasal bleeding in patients with hht colonized with sataphylococo before and after being treated with mupirocin ointment.

hereditary hemorrhagic telangiectasia is a vascular dysplasia characterized by the development of mucocutaneous telangiectasia and arteriovenous malformations in organs such as brain, lung, liver and tube digestivo. is considered a rare disease, although it means that there is a substantial underdiagnosis. the overall prevalence is 1/5000. approximately 60% of the general population hosts strains of staphylococcus aureus (s. aureus) intermittently and are called intermittent carriers, 20% represent persistent carriers harboring the same strain of s. aureus and 20% of the population are never carriers. on this concept, one might think that hht patients in whom there is an active and pathological vascular remodeling that causes bleeding, and inflammation is a known activator of abnormal angiogenesis; reducing an inflammatory factor as microbial through the eradication of nasal s. aureus could be useful to reduce bleeding in this population, directly impacting on quality of life.

Eligibility criteria:
inclusion criteria: * patients over 18 years with possible or confirmed hht as diagnostic criteria curaçao. * patients with nasal s. aureus colonization culture positive exclusion criteria: * refusal to participate in the study or the informed consent process. * hypersensitivity or contraindication for topical mupirocin.

Keywords: hereditary hemorrhagic telangiectasia epistaxis
stitch closure of pfo and septal repair

Conditions: Foramen Ovale, Patent; Septal Defect, Atrial; Septal Defect, Heart

Summary: the purpose of the stitch study is to evaluate closure rates of clinically relevant septal defects, including patent foramen ovale (pfo), atrial septal defects (asd - less than 1 cm with redundant septal tissue), trans septal puncture sites, repair of atrial septal aneurysm (asa) and rate of recurrent neurologic embolic events in patients with cryptogenic stroke and pfo.


Eligibility criteria:
inclusion criteria: * pfo * asd (less than 1 cm with redundant septal tissue) * trans septal puncture sites * asa (when an appropriate pfo or small asd defect is present) * stroke * trans ischemic attack (tia) * platypnea orthodeoxia syndrome * decompression illness exclusion criteria: * patients under 18 and over 65 * patients who are not fluent in english
mesenchymal stem cells therapy in patients with recent intracerebral hemorrhage

Conditions: Hemorrhagic Stroke; Intracerebral Hemorrhage

Summary: the overall goal of this study is to develop mesenchymal stem cell therapy for treatment of acute spontaneous hemorrhagic stroke.

the overall clinical development strategy of this project is to conduct this phase i dose escalation study entitled "a pilot study to evaluate the safety and feasibility of mesenchymal stem cells therapy in patients with recent intracerebral hemorrhage". this study will be performed under this current ind application and will be limited to the proposed 12 subjects (3 iv and 1 it dose groups). in this application the investigators are proposing to evaluate safety and feasibility of allogeneic, bone marrow (bm) derived mesenchymal stem cells (msc) to induce neuroregeneration, improve neurological function and alleviate inflammation.

Eligibility criteria:
* age range: 18 years or older * gender: male or female * acute spontaneous supratentorial ich documented by head ct with ich score between 2 - 4 inclusive * stable ich hematoma volume 60ml or less as measured by abc2 method by 24-72hrs * ability to be enrolled within 72 hours of onset of stroke symptoms * ability to provide written personal or surrogate consent. only subjects who have signed the icf will be enrolled into the study. the icf will include elements required by mayo irb and fda in us 21cfr50. * subject must have adequate renal function; creatinine \<1.5g/dl. * subject must be available for all specified assessments at the study site through the completion of the study. * subject must provide written icf and authorization for use of and disclosure of phi.

Keywords: mesenchymal stem cell stroke intracerebral hemorrhage cell therapy
health, integration, concentration: mindfulness in schools

Conditions: Mindfulness; Child Development; Burnout Syndrome

Summary: mindfulness training for teacher and children of primary schools. blinded and controlled study design. burnout as primary outcome for teacher and classroom behavior for children.


Eligibility criteria:
inclusion criteria: * reading ability * positive declaration of consent exclusion criteria: -

Keywords: mbsr children teacher school burnout classroom behavior
lymph node mapping in finding metastatic disease in patients with sebaceous gland cancer of the eyelid

Conditions: Eyelid Sebaceous Gland Carcinoma

Summary: this phase ii trial studies how well lymph node mapping works in finding disease that has spread from the place where it started to other places in the body in patients with sebaceous gland cancer of the eyelid. lymph node mapping may help in planning surgery to remove cancer and affected lymph nodes.

primary objectives: i. identify the rate of sln (sentinel lymph node) positivity for eyelid sebaceous gland carcinomas. ii. identify the false negative events associated with sln biopsy for sebaceous gland carcinomas. secondary objective: i. record any side effects associated with sln biopsy for sebaceous gland carcinoma of the eyelid. outline: patients receive technetium tc 99m sulfur colloid intradermally (id) and then undergo lymph node mapping and sln biopsy. after completion of study treatment, patients are followed up every 3 months for 1 year and then every 6 months for 4 years.

Eligibility criteria:
inclusion criteria: * possible or suspicious sebaceous gland carcinoma of the eyelid * a cxr (chest x-ray), liver enzymes, and a head and neck computed tomography (ct), a single photon emission computed tomography (spect/ct) or magnetic resonance imaging (mri) and an ultrasound negative for clinical evidence of metastasis * patient provided written informed consent; in the event that non-english speaking participants are eligible for this study, a short form (if applicable) or an informed consent document (icd) in their language, will be utilized and completed in accordance with the m.d. anderson cancer center (mdacc) policy for consenting non-english speaking participants exclusion criteria: * pregnant or nursing females
efficacy of injectable vitamin c on accelerating canine movement: a clinical study

Conditions: Palatally Impacted Canines

Summary: efficacy of the injectable vitamin c to reduce the time of canine traction

objective. the purpose of this study is to investigate the role and efficiency of the locally injected vitamin c in the enhancement of the palatally impacted canine movement. design. twelve adult patients with unilateral palatally impacted canines were included in this study. the enrolled patients were randomly allocated into the study groups; control group; orthodontic traction and he test group: orthodontic traction enhanced by intraepidermic vitamin c injection. the study duration was 12 months.

Eligibility criteria:
inclusion criteria: * medically free * patient with good to fair oral hygiene (gingivitis may be included) * both sexes were included * unilateral palatally positioned permenant canines * absence of previous orthodontic treatment * absence of supernumerary teeth, odontoms, cysts, traumatic injuries * the α angle within grade ii to iii exclusion criteria: * systemic diseases especially diabetes and bone diseases * pregnant and lactating mothers * local causes (smoking, mouth breathing, local trauma and periodontitis).

Keywords: vitamin c palatally impacted canines intraepidermal injection
poorly differentiated adenocarcinoma with signet ring cells of the gallbladder producing a high level of alpha-fetoprotein: a case report

Conditions: Gallbladder Cancer

Summary: alpha-fetoprotein (afp) can become elevated in hepatocellular carcinoma (hcc), yolk sac tumors and other malignant tumors of various organs. herein, the investigator present a case of afp-producing gallbladder carcinoma with signet ring cells successfully treated with laparoscopic whole-layer cholecystectomy.


Eligibility criteria:
the study eligibility criteria for patient were as follows: afp-producing gallbladder carcinoma (ct2an0m0, cstage iia, uicc 8th) or gallbladder metastasis from hcc.
pre-emptive analgesic administration in primary tooth extraction

Conditions: Local Anesthesia; Tooth Extraction

Summary: brief summary: aims: the objective of the current study will be to compare the effectiveness of ibuprofen, acetaminophen, and placebo on reducing injection pain and post-operative pain in primary tooth extraction, and to compare the parents' satisfaction. design: this will be a blinded, randomized placebo-controlled trial including sixty six cooperative children, aged 6-8 years old.

background and aims: the pain could be a problem for the patients during the first few hours after the extraction because of both soft and hard tissues trauma during the operation, despite that the local anesthesia will last for a long time in most of the cases. there are no enough studies that ensure the validity of giving any analgesic in reducing injection pain and post-operative pain in primary tooth extraction so far. design: this will be a blinded, randomized placebo-controlled trial including sixty six cooperative children, aged 6-8 years old, randomly assigned to one of three groups to receive one of the oral suspension drugs, that have the same colour and taste, via pre-calibrated medication bottles, which are identical, numbered and containing the same amount of pre-calibrated dosages, as per the following portions: 1. acetaminophen syrup: 160mg/5ml 2. placebo solution 3. ibuprofen suspension: 100mg/5ml

Eligibility criteria:
inclusion criteria: 1. teeth with an abscess or infection exceeding one-third of the interradicular area (not exceeding the oral cavity) 2. unrestorable decayed teeth. 3. teeth with periapical / interradicular lesions. - exclusion criteria: teeth with advanced root resorption (a third of the root at least)

Keywords: pre-emptive administration analgesic tooth extraction
the value of 68ga-fapi pet/ct in preoperative evaluation of thyroid cancer with lymph node metastases

Conditions: Thyroid Cancer

Summary: this study aims to investigate the value of 68ga-fapi in the preoperative evaluation of thyroid cancer of different pathologic types.

the investigators will number all participants, create a medical record file, and record their basic information (gender, age) as well as contact information and medical history information. all participants will undergo a 68ga-fapi pet/ct before surgery. the imaging response measurements will be compared with the histopathological results as gold standard.

Eligibility criteria:
inclusion criteria: 1. pathological and clinical diagnosis of thyroid cancer with lymph node metastases. 2. signed and dated informed consent form. 3. commitment to comply with research procedures and co-operation in the implementation of the full research process. 4. aged 16-80 years old. exclusion criteria: 1. patients with serious illnesses that researchers consider unsuitable for participation in this clinical study. such as severe heart and lung failure, severe bone marrow suppression, severe liver and kidney dysfunction, etc. 2. intestinal perforation, complete intestinal obstruction. 3. pregnant women and women who may be pregnant, women who are breastfeeding. 4. non-compliant person.

Keywords: thyroid cancer 68ga-fapi pet/ct