Kornimate/medical-research-clean huggingface dataset:
a placebo controlled trial of dalfampridine er for ambulatory activity in people with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: a randomized placebo controlled double-blind cross-over trial of dalfampridine er for effect on ambulatory activity in people with multiple sclerosis

this is a parallel-group, double-blind, randomized controlled crossover trial with a 1:1 randomization. there are two treatment periods of 4 weeks and a two-week off treatment washout period. treatment periods are der (dalfampridine er) followed by placebo (group a) and placebo followed by der (group b), respectively. all dosages will be administered twice a week. purpose of the study is to see if using the study drug(dalfampridine er) for a short period of time will improve the way subjects with multiple sclerosis (ms) walk.

Eligibility criteria:
inclusion criteria: * diagnosis of ms made at least 3 months prior to based mcdonald or proser criteria. * age 18-75 years old inclusive. * expanded disability status scale (eds) 0-6.5 * clinical stability defined as no ms exacerbation or change in disease modifying therapy for 60 days prior to screening. * screening 6-minute walking test distance between 50m-500m, inclusive. * written informed consent. exclusion criteria: * use of 4-aminopyridine within 6 months of screening * any contraindication to der: * allergy to der * history of seizure disorder or history of eeg showing epileptiform activity * renal insufficiency (estimated gfr \< 60. * any condition that would exclude 6 minute walking testing: * cardiac surgery or myocardial infarction within the last 3 months. * severe aortic stenosis or hypertropic cardiomyopathy. * pulmonary embolus or infarction in the last 6 months. * uncontrolled hypertension by history or by screening or baseline diastolic blood pressure \> 170, or systolic blood pressure \> 105. * use of oxygen at home for 24 hours/day or severe lung disease. * history of ventricular arrhythmia or finding of significant ventricular arrhythmia. atrial arrhythmia or 2nd or 3rd degree heart block on screening ecg. * concomitant neurological disease, such as als, parkinson disease, stroke. * hospitalization in the last 6 months for psychiatric illness. * alcohol or drug abuse within the past year. * females who are breast-feeding, pregnant or have potential to become pregnant during the course of the study( fertile and unwilling/unable to use effective contraceptive measures) * cognitive deficits that would interfere with the subject's ability to give informed consent or preform study testing. * any other serious and/or unstable medical condition. * use of mitoxantrone (novantrone) within 6 months of baseline visit.

Keywords: ambulation
optimizing patient-centred outcomes using opioid minimization strategies: the opus anesthesia pilot trial

Conditions: Anesthesia; Anesthesia Complication; Surgery; Quality of Life; Pain, Postoperative; Anesthesia Morbidity; Feasibility Studies; Patient-centredness

Summary: up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence. few preventive interventions exist, but intravenous dexmedetomidine and lidocaine administered during general anesthesia represent simple strategies that may significantly impact recovery and other patient-centred outcomes after surgery. the goal of this pilot trial is to determine the feasibility of conducting a phase 3 pragmatic adaptive multicentre trial to evaluate the impact of dexmedetomidine and lidocaine administered during major non-cardiac surgery on patient-centred outcomes.


Eligibility criteria:
inclusion criteria: 1. adults \>/= 18 years. 2. having elective major non-cardiac surgery (i.e., planned duration \>/= 1.5 hours and anticipated \>/= 1 night hospital stay). 3. requiring general anesthesia. 4. able to complete baseline quality of recovery assessment. exclusion criteria: 1. individuals with known contraindications to dexmedetomidine or lidocaine (e.g., allergy to alpha-2 agonists or local anesthetics, severe renal or hepatic failure, bradycardia or hypotension), as per routine assessment. 2. regular use of alpha-2 agonists or local anesthetics prior to hospitalization. 3. pregnant women. 4. planned use of regional analgesia (i.e., epidural, peripheral nerve block, trunk nerve block) in conjunction with general anesthesia. local anesthetics such as lidocaine are administered as part of regional analgesia technique. combination with intravenous lidocaine is contraindicated to avoid exceeding therapeutic concentration. 5. planned postoperative intubation after pacu discharge. 6. no fixed address.

Keywords: pilot trial anesthesia quality of recovery postoperative pain opioid minimization strategies dexmedetomidine lidocaine patient-centred outcomes
qtc and perceived sleep follow up among chronic pain patients with opiate medication

Conditions: Chronic Pain

Summary: qtc: since the reports of three deaths attributed to torsade de point (tdp) related to treatment with the long-acting methadone derivative levomethadyl acetate hcl (laam), methadone has been scrutinized for any possible association with tdp. since then, several studies among methadone maintenance treatment (mmt) patients and chronic pain patients were done, reporting diverse results about possible association between methadone dose and qtc prolongation. most studies however were cross-sectional and generally found insignificant clinical prolongation of qtc. a follow up studies are of importance, and although few studies have started evaluating qtc among mmt patients, none was done among chronic pain patients with no history of drug usage. one study of 8 chronic pain patients experiencing insufficient pain control or intolerable side effects during treatment with oral morphine switched to oral methadone showed insignificant modest increase qtc following 9 month. perceived sleep: chronic pain patients as well as drug addicts are known to suffer from poor sleep. some studies found possible relation to methadone dose, however, no causal association was found and importantly some also found association with duration of opiate usage before starting methadone when entry to mmt clinic. thus, patients with no history of opiate addiction are an important interesting group that may help understand relation between methadone usage and sleep quality. however, sleep must be evaluate before opiate administration and a follow up study is needed


Eligibility criteria:
inclusion criteria: * adults (18+ years) patients with chronic pain, who intend to be medicated with any opiates exclusion criteria: * patient with no opiate usage through last year

Keywords: chronic pain methadone perceived sleep qtc
cognitive multisensory on upper extremity in stroke

Conditions: Stroke

Summary: purpose: to investigate the effect of cognitive multisensory rehabilitation program on upper extremity function in stroke patients. background: cognitive multisensory rehabilitation (cmr) is a promising therapy for upper limb recovery in stroke, as the cmr considered an effective therapy for motor recovery for adults with stroke

thirty patients with stroke the patients will randomly be divided into two equal groups; the control group which received the selected exercise program and the study group received the same exercise training program in addition to cognitive multisensory rehabilitation program, three times per week for 2 months. the evaluation methods action research arm test (arat), fugl-myer assessment upper extremity (fma-ue), manual function test and motor evaluation scale for upper extremity

Eligibility criteria:
inclusion criteria: 1. thirty hemiplegic patients, with the onset of stroke six months or longer. 2. both sexes, with ages ranging from 45: 60. 3. body mass index will range from 18.5-to 29.9 kg/m2. exclusion criteria: 1. other brain injuries/illnesses, cognitive impairment, severe sensory or proprioceptive loss. 2. other causes of hemiplegia. 3. other causes of upper extremity dysfunction.
role of dopamine receptors in primary focal dystonias

Conditions: Healthy; Focal Dystonias

Summary: dystonia is a disabling movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures that may afflict 250,000 people in the u.s. while the pathophysiology of dystonia remains uncertain the treatment is rather rudimentary. a better understanding of neural mechanisms of dystonias is not only an invaluable prerequisite for developing better treatment options but also a step toward better understanding of the complex network of basal ganglia. in this study i will investigate if there is any difference between the dopamine receptors and dopamine in people with dystonia and healthy subjects.


Eligibility criteria:
inclusion criteria: * age \>20 * male or female * any race or ethnicity * primary focal dystonia (arm or cranial) * ability to give informed consent exclusion criteria: * family history of dystonia * pregnancy (confirmed with negative urine pregnancy test in women of child bearing potential), breastfeeding * exposure to radiation therapy * any mri contraindications such as foreign metallic implants, pacemaker, and aneurysm clip etc. * history of cardiac disease, uncontrolled hypertension, abnormal ekg during screening phase * history of exposure to any drugs affecting dopaminergic systems within the last 6 months (e.g. dopamine receptor blocking agents, cocaine, amphetamine, tetrabenazine, reserpine, l-dopa, dopamine agonists, as they might affect the dopamine receptor binding or endogenous dopamine). * active depression (beck depression inventory_ii \>14) * cognitive impairment (mini-mental state score \<27) * cns active medications such as gabapentin or narcotics, muscle relaxants which might be given for pain in the 3 days prior to study * history of stroke, seizure, cerebral palsy, generalized dystonia, parkinsonism, inability to hold head still during the scanning time.

Keywords: focal dystonia dopamine receptor
safety and immunogenicity of 2 different vaccination schedules of rabies and japanese encephalitis vaccines in healthy adult subjects

Conditions: Rabies; Japanese Encephalitis

Summary: establish non-inferiority of the immune response and evaluate the safety and tolerability of rabies and japanese encephalitis (je) vaccines given concomitantly or alone and according to either of 2 schedules for preexposure prophylaxis.


Eligibility criteria:
inclusion criteria: 1. males and females between 18 and 65 years of age (inclusive). 2. subjects who have given written consent. 3. individuals in good health as per investigator judgement. exclusion criteria: 1. if female, pregnancy or unwillingness to practice acceptable contraception. 2. if female, pregnant or breast-feeding or any positive/indeterminate pregnancy test. 3. contraindication or precaution against rabies and japanese encephalitis vaccination. 4. unable to comprehend and to follow all required study procedures for the whole period of the study. 5. participating in any other clinical trial 30 days prior to first study visit. 6. history of previous rabies/rabies immunoglobulin and/or japanese encephalitis immunization. 7. receiving or planning to receive anti-malarial medications (e.g. mefloquine) 14 days prior to day 1 vaccination through day 43. 8. received any other vaccines within 2 weeks prior to enrollment in this study or plan to receive any vaccine within 4 weeks from the study vaccines. 9. ever received blood, blood products and/or plasma derivatives or any parenteral immunoglobulin preparation in the past 12 weeks. 10. individuals who are part of study personnel or close family members conducting this study. 11. body temperature ≥38 degrees celsius (≥ 100.4° f) within 3 days of intended study vaccination. 12. plans to travel within the next year to areas where rabies and/or japanese encephalitis vaccine may be considered or offered. this includes but is not limited to india, asia, pacific-rim, african countries.

Keywords: rabies je accelerated schedule
the effect of lateral wedge insole for knee osteoarthritis patient in plantar pressure, quadriceps thickness, gait and walking speed

Conditions: Osteoarthritis, Knee

Summary: investigators would let knee osteoarthritis patient dressing lateral wedge insole and evaluate the effect for foot pressure modification, quadriceps thickness detected with ultrasound and gait. investigators would made the patient in control group dressing ordinary insole.

knee osteoarthritis is one of the most popular disease affected elderly people and made them discomfort. there was no study using foot pressure as a parameter about lateral wedge insole intervention for the knee osteoarthritis patient. the purpose of this study was to investigate the effect of lateral wedge insole for the patient of knee osteoarthritis. during total period of 12 weeks for the study, investigators randomized the patient into experimental and control group. then investigators evaluated the patient's foot pressure, quadriceps thickness, stride length, stride width, walking speed, pain scale and daily function before intervention, 4th weeks, 8th weeks and 12th weeks. investigators would use pressure insole designed in the industrial technology research institute in taiwan. the portable device used in this study maybe suitable for evaluation of other lower limb disease. there were studies evaluating elderly people dysfunction, critical illness muscle atrophy or knee joint disease with ultrasound detected quadriceps thickness. but there was no study about the correlation between foot pressure and quadriceps thickness for evaluating the effect of lateral wedge insole. investigators hoped to make a new model for evaluating lower limbs disorder in the future.

Eligibility criteria:
inclusion criteria: * knee osteoarthritis patients * medial knee pain exclusion criteria: * unable to walk independently * ambulation with device * any neurologic disease * rheumatoid arthritis, gouty arthritis * history of lower limbs fracture * history of operation for lower limbs * any infectious disease
eval earlysense bet lowenstein sleeplab

Conditions: Obese; Sleep Apnea, Obstructive; Central Apnea; Sleep Disorders; Poor Quality Sleep

Summary: the study objective is to collect heart rate, respiration rate and motion data of patients admitted to sleep lab and to determine the accuracy level of the earlysense system vs. the monitors used in sleep lab (e.g., polysomnography, respiratory belts, ecg, etc..) . data regarding sleep condition, scoring and quality of sleep and in and out of bed status, patient turns will also be collected and compared to data collected by earlysense contactless monitor. different patient population will be monitored including obese, morbidly obese, patients with or without obstructive/central apnea, patients with or without arrhythmia as well as healthy population who arrive to sleep lab for general evaluation will be monitored

earlysense sensors will be placed under the mattress of subjects who have been included in the study. the sensors will not be in any contact with the patient. two sensors will be utilized and placed under the subject's chest and pelvis area. accuracy of the sensors will be compared to each other and to the reference device.

Eligibility criteria:
inclusion criteria: 1. age 18 years or above 2. is willing to sign the consent form exclusion criteria: 1. age \< 18 years 2. is not willing to sign the consent form
the turkish version of the musculoskeletal pain intensity and interference questionnaire for musicians (mpiiqm-t)

Conditions: Musculoskeletal Pain; Questionnaire

Summary: the aim of this study, original named "the musculoskeletal pain intensity and interference questionnaire (mpiiqm)" is the turkish validation, reliability and cross-cultural validation of the questionnaire.


Eligibility criteria:
inclusion criteria: * permanent musician in an orchestra * understand and reading turkish exclusion criteria: * freelance musician

Keywords: musician orchestra musicians musculoskeletal pain questionnaire
falls prevention through physical and cognitive training in mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: this randomised controlled trial aims to determine the effectiveness of combined physical and cognitive training in preventing falls and decreasing risks of falls among community-dwelling older persons with mild cognitive impairment (mci).

this is a single-blind, multicentre, randomised controlled trial. community-dwelling older adults with mci aged 60 or above will be recruited. they will be randomly allocated into four groups: physical training alone (pt), cognitive training alone (ct), combined physical and cognitive training (pact) and wait-list group (wg). assessors blinded to participant allocation will conduct pre-test, posttest, and 6-month follow-up assessments.

Eligibility criteria:
inclusion criteria: * 60 years or above * community-dwelling in manila, philippines * diagnosed with mci exclusion criteria: * diagnosis of dementia or alzheimer's disease * history of major medical conditions such as cerebrovascular disease, cardiopulmonary condition, serious musculoskeletal disease, cancer, major psychiatric condition * have severe visual and/or hearing impairment * taking medications such sedatives, antidepressants, diuretics, anti-epilepsy.

Keywords: falls prevention, older adults, mild cognitive impairment
a mobile application developed for children with urinary incontinence

Conditions: Urinary Incontinence

Summary: the study included 2 stages: in the first, a mobile application with content including urotherapy training and patient follow-up was developed. in the second, a pilot study with the developed mobile application was carried out with 10 children.

the study include two stages. in the first, a mobile application was developed that can be used by children with urinary incontinence and their parents. the mobile application includes the training on urinary incontinence and urotherapy in children as well as all the test results of the child and ensures the follow-up of the children's compliance with the treatment. the developed mobile application is operatable on smartphones and tablets with android and ios operating systems. this was followed by the second phase, during which the mobile application developed was pilot tested with 10 children. based on the feedback received from the users, the mobile application was finalized. mobile application development process 1. content creation for goals 2. interface design development on ms word and photoshop 3. evaluation by specialists for content and design 4. converting to mobile application on android and ios platforms 5. a pilot study with 10 children to evaluate the usability and suitability of the application 6. get feedback on the mobile app 7. based on this feedback, the mobile application was revised. 8. its final version was created

Eligibility criteria:
inclusion criteria: * the child has day and/or night urinary incontinence, * the child is between 7-12 years of age, * family members and children can use mobile applications, * family members have a smartphone, * the child and family members volunteers to participate in the study. exclusion criteria: * the child has a mental or neurological disability, * the child has a developmental delay, * the child has previously received treatment for urinary incontinence, * the child has a communication problem, * the child has a history of surgery related to the urinary tract, * the child has a psychiatric diagnosis, * the child has a urinary tract infection, * the child has a radiological pathology on ultrasound, * the child has a diagnosis of neurogenic bladder.

Keywords: mobile application child quality of life
effect of forward head and rounded shoulder posture on hand grip strength in asymptomatic young adults

Conditions: Muscle Weakness

Summary: * see if there is significant difference between subjects with forward head rounded shoulder posture and subjects with normal posture in hand grip strength in asymptomatic young adults * see if there is significant difference between subjects with rounded shoulder posture and subjects with normal posture in hand grip strength in asymptomatic young adults

* in forward head posture there is flexion in lower cervical vertebrae that causes tension on lower cervical nerve roots according to harrison systemic review and these lower cervical nerve roots supply hand muscles * also in rounded shoulder posture there is weakness in scapular stabilizers and retractors which affect proximal stability of the arm * proximal stability is important for distal mobility * so from this biomechanical point of veiw we conduct this study to see if forward head and rounded shoulder posture can affect hand grip strength in asymptomatic young adults.

Eligibility criteria:
inclusion criteria: 66 subjects from both genders sedentary life. * 22 subjects with rounded shoulder posture with the distance between on the table and the posterior aspect of lateral part of acromion process ≥ 2.5 cm * 22 subjects with forward head rounded shoulder posture with craniovertebral angle ≤ 50 and the distance between on the table and the posterior aspect of lateral part of acromion process ≥ 2.5 cm * 22 subjects with normal posture * asymptomatic participants * age range from 19-24 years old * normal body mass index * right handed subjects exclusion criteria: * • neck or shoulder symptoms * shoulder fracture * shoulder dislocation * radiculopathy * recent shoulder surgery * athletes * musculoskeletal abnormalities

Keywords: rs-fhrsp-grip strength
phase ii clinical study to evaluate the efficacy and safety of vc005 in adult subjects with mild to moderate atopic dermatitis

Conditions: Atopic Dermatitis

Summary: a multicenter, randomized, double-blind, vehicle controlled phase ii clinical study


Eligibility criteria:
inclusion criteria: 1. subjects fully understand this study, are able to follow the relevant procedures of the trial, voluntarily participate in the clinical trial, and sign the informed consent form (icf); 2. the age requirement for signing the icf is 18 years old or above, with no gender restrictions; 3. during screening, the diagnosis of atopic dermatitis should be met according to the hanifin-rajka criteria; exclusion criteria: 1. skin damage or abnormalities that may affect the evaluation of the administration site of the investigational drug; 2. skin diseases that are contraindicated in research or affect the evaluation of drug administration sites, including but not limited to psoriasis, acne, and skin cancer; 3. suffering from autoimmune diseases other than ad, such as inflammatory bowel disease and rheumatoid arthritis, and the researchers believe that this disease will be detrimental to the evaluation of this study; 4. current history of or presence of lymphoproliferative disorders, or signs or symptoms suggesting possible lymphoproliferative disorders, including lymphadenopathy or splenomegaly; 5. various malignant tumors, or any history of malignant tumors within the past 5 years prior to screening (excluding completely resected cervical carcinoma in situ, non metastatic squamous cell carcinoma, basal cell carcinoma, or papillary thyroid carcinoma);