Kornimate/medical-research-clean huggingface dataset:
waveform analysis of the doppler curve of ophthalmic arteries in glaucoma patients

Conditions: Open-angle Glaucoma; Low Tension Glaucoma

Summary: color doppler imaging (cdi) has been providing information about ocular blood flow over the past decades. this non-invasive procedure based on ultrasound technique has identified increased resistance and decreased systolic blood velocities to exist in the ophthalmic arteries of glaucoma patients. however, existing data has provided very little information regarding the analysis of the doppler waveform in itself and to whether variables such as early systolic acceleration or systolic/diastolic velocity ratios are of any significance in glaucoma disease. in other medical specialties using cdi technology, such as nephrology or cardiology for instance, this analysis has been part of the normal routine. this information has been used in screening patients for disturbed circulation such as arterial stenosis or providing information regarding prognosis of renal and hepatic transplants have been used for decades now. what is the normal characteristics of the waveform doppler analysis? to answer this, the investigators will create a normative database using healthy controls. are there signs of altered stiffness or compliance in the ophthalmic arteries of glaucoma patients? to answer this, the analysis of early acceleration acceleration and detection of an early peak systolic will be done on the doppler curves of glaucoma patients and compared to the healthy normative database. are there any difference between the two types of glaucoma \[primary open-angle glaucoma (poag) and normal-tension glaucoma (ntg)\]? the investigators will compare the variables of the ophthalmic artery waveform in these two groups. do any of these doppler waveform variables have any clinical significance? to answer this, the investigators will search for the existence of any correlation between the waveform data and both functional (visual field testing) and structural (confocal scanning laser ophthalmoscopy - cslo) variables of the glaucoma groups.

1. color doppler imaging of the ophthalmic artery will be performed 2. visual field testing will be done 2. cslo will be done

Eligibility criteria:
inclusion criteria: * • individuals over 18 years old * willing to sign an informed consent and able to comply with the requirements of the study * having no other ocular diseases besides glaucoma exclusion criteria: * • history of ocular trauma * intraocular surgery (except for cataract surgery) * eye disease (except glaucoma) * systemic diseases with ocular involvement like diabetes

Keywords: open-angle glaucoma low tension glaucoma color doppler imaging
optimal time for staple/dressing removal

Conditions: Surgical Wound Healing; Surgical Wound Infection; Patient Satisfaction

Summary: the medical literature does not provide sufficient information or recommendation regarding the optimal time to remove the staples and the bandage after a cesarean section. the goal of this study is to compare 5 groups of patients: 1. staple removal on pod 4 and dressing removal on post operative day (pod)1 2. staple removal on pod 4 and dressing removal on post operative day (pod)4 3. staple removal on pod 7 and dressing removal on post operative day (pod)1 4. staple removal on pod 7 and dressing removal on post operative day (pod)7 5. staple removal on pod 4 and dressing removal on post operative day (pod)7 since there is no definite protocol for staple and dressing removal, we will adapt the above protocol each for a 3-4 month period of time. patients will be contacted to either return for a follow up visit or to answer a telephone survey.


Eligibility criteria:
inclusion criteria: * patients undergoing a cesarean section at our facility exclusion criteria: * patients lost to follow up

Keywords: caesarian section surgical wound
ultrasound-guided supraclavicular brachial plexus blockade

Conditions: Pain

Summary: pain clinic patients undergoing physiotherapy for rehabilitation often have arm freezing performed. the quality of physiotherapy is felt to be superior with good pain control. the quality of the freezing is felt to be better when it is done with ultrasound guidance. we are able to use less drug to achieve the same result. for this reason, we are doing a study to look at the level of freezing drug that accumulates in the body. we feel that the drug levels will be significantly different. we also feel that the time-to-peak drug level will be different than with traditional arm freezing procedures.


Eligibility criteria:
inclusion criteria: * patients undergoing brachial plexus anesthesia as part of disease management who have consented to participate in the study exclusion criteria: * contraindication to brachial plexus anesthesia * informed consent not obtained

Keywords: pain brachial plexus anesthesia plasma lidocaine levels ultrasound
kinesia 360 parkinson's monitoring study

Conditions: Parkinson's Disease

Summary: kinesia 360 is an ambulatory symptom monitoring device for parkinson's disease (pd). the aim of this study is to investigate the impact, validation, and usability of the kinesia 360 system.

this is a five-month study of 45 subjects (approximately 15 subjects per site), consisting of adult volunteers that have been clinically diagnosed with parkinson's disease. subjects will have a confirmed history of motor fluctuation with a variety of parkinson's disease symptom severities. all subjects will user the kinesia 360 system and complete motor diaries several times per month during the study period. symptom reports will be provided to the treating clinical team. motor function, quality of life, engagement, and satisfaction with care will be tracked throughout the study.

Eligibility criteria:
inclusion criteria: * idiopathic parkinson's disease, * history of motor fluctuations (2 hrs/day of off time and/or 1 hr/day of troublesome dyskinesia) * fluent in english exclusion criteria: * inability to carry out study activities * subjects with cognitive deficits that would prevent following instructions and serious medical conditions that would compromise a subject's safety * subjects who have dementia, exhibited by montreal cognitive assessment (moca) score of 22 or less. * subjects who have had deep brain stimulation (dbs) surgery less than 6 months prior to study enrollment, or who are deemed by the study investigator to be highly likely to undergo dbs surgery during the 6 month study period.

Keywords: parkinson's disease dyskinesia tremor symptom management technology wearable sensors continuous monitoring mobility
a phase 2 trial to evaluate if corifollitropin alfa (org 36286), followed by a low daily dose of hcg or recombinant fsh can induce monofollicular growth in women with who group ii anovulatory infertility (p05693)

Conditions: Ovulation Induction

Summary: the primary objective of this trial is to evaluate whether a corifollitropin alfa (org 36286) regimen applying a single or repeated dose of corifollitropin alfa followed by a low daily dose of human chorion gonadotropin (hcg) or recombinant follicular stimulating hormone (recfsh) can induce monofollicular growth (one follicle ≥18 mm and no other follicle ≥15 mm at day of bolus injection of hcg) in women with who group ii anovulatory infertility.

this trial will include two separate stages (ia+ib and ii). stage ia will be open-label and uncontrolled in a small cohort of women (n=5) to explore whether the intended dosing regimen of corifollitropin alfa followed by daily low dose recfsh provide an appropriate response in eligible participants meeting all inclusion and none of the exclusion criteria. stage ib will be open-label and uncontrolled in a small cohort of women (n=5) to explore whether the intended dosing regimen of corifollitropin alfa followed by daily low dose hcg provide an appropriate response in eligible participants meeting all inclusion and none of the exclusion criteria. stage ii is open-label and randomized (n=40) to evaluate whether the intended dosing regimen of corifollitropin alfa followed by low dose fsh (n=20) or hcg (n=20) provide an appropriate response in eligible participants meeting all inclusion and none of the exclusion criteria.

Eligibility criteria:
inclusion criteria: * oligomenorrhea (average cycle length ≥35 days and \<6 months) * amenorrhea (average cycle length ≥6 months) * body mass index ≥18 and ≤30 kg/m\^2 * normal serum fsh levels and normal estradiol levels at screening * progestagen induced withdrawal bleeding * age ≥18 years and ≤39 years at the time of signing informed consent * willing and able to sign informed consent exclusion criteria: * history of or current ovarian cysts or enlarged ovaries not related to polycystic ovarian syndrome (pcos) * history of or current tumors of the ovary, breast, uterus, pituitary or hypothalamus * less than 2 ovaries * undiagnosed vaginal bleeding * any ovarian and/or abdominal abnormality interfering with ultrasound examination * malformations of the sexual organs incompatible with pregnancy * pregnancy or lactation * abnormal serum endocrinology levels based on screening sample * any clinically relevant abnormal laboratory value based on screening sample * alcohol or drug abuse within the 12 months preceding signing of informed consent * hypersensitivity to any of the substances in corifollitropin alfa * hypersensitivity to hcg/ puregon® or any of its components * previous use of corifollitropin alfa * use of any investigational drug during 90 days before screening

Keywords: pharmacological effects of drugs hormones hormone substitutes and hormone antagonists pharmacological actions monofollicular growth randomized open-label active-controlled
children's mri experience

Conditions: Behavior; Psychological Distress; Anxiety

Summary: the study aims to investigate the effect of philips ambient experience with specially designed paediatric content on the experience of pediatric patients undergoing an mri examination, their caregiver, and clinical staff, on workflow and on clinical outcome. the designed paediatric content exists of personal selection of a character, video projection on the wall and/or a screen visible when in the bore, audio, and room ambience lighting. the study will be conducted in collaboration with six partner hospitals within the eu. at each hospital, 50 pediatric patients between 6 and 12 years old will be included in the study.


Eligibility criteria:
inclusion criteria: * patients between 6 and 12 years old * scheduled for a head-first mri scan * parent/guardian and child speak and read the local language. * positive judgement by on-site pi/(co-) investigator for awake scanning exclusion criteria: * general anesthesia * clinically diagnosed cognitive, or developmental disorder (e.g. adhd, asd) or neurological problems that prevent the ability to lie/hold still for an mri scan while awake * previous mri examination with philips ambient experience
attitudes and stigma towards suicidal behavior in intensive care and emergency service nurses

Conditions: Suicide; Stigma, Social

Summary: the aim of this study is to determine the attitudes and stigmatization levels of nurses working in the intensive care and emergency departments towards suicidal behavior.

suicide is an important and priority public health problem. in the last 45 years, the suicide rate in the world has increased by 60%. about 800,000 people die each year due to suicide. suicide can be prevented with timely, evidence-based, and often low-cost interventions. the first places that individuals who attempt suicide apply are often the emergency departments of hospitals. these individuals are then referred to intensive care units for close follow-up of physical findings and treatment according to the results of the suicide attempt. nurses working in the emergency room and general intensive care unit should consider the need for psychosocial support while taking precautions against the physiological consequences of suicide in order for the individual to survive. in the care of an individual who has attempted suicide, the nurse has responsibilities such as providing education to the patient, creating a safety plan, counseling for the restriction of deadly vehicles, quick referral to the necessary places, and providing contact with post-discharge care. it is a priority in the care of the individual that the nurse reduces the sense of hopelessness of the individual who comes with a suicide attempt, re-establishes the sense of commitment to other people, increases compliance with the treatment, motivates for change, and establishes therapeutic communication. in this regard, the knowledge level of healthcare professionals and nurses who provide primary care to patients, and their attitudes towards suicide are important. when the literature is examined, studies on the attitudes of health professionals working in the emergency room toward suicide attempts have been observed, but no research has been found that determines both the attitudes and stigmatization levels of intensive care and emergency room nurses toward suicidal behavior. for this reason, this study was planned to determine the attitudes and stigmatization levels of nurses working in the general intensive care and emergency departments towards suicidal behavior.

Eligibility criteria:
inclusion criteria: * having no barriers in oral and written communication in turkish * volunteering to participate in research * working in the general intensive care or emergency department of the hospital exclusion criteria: * giving incomplete or incorrect information to forms

Keywords: suicide stigma
initial assessment of an internet-based symptom management intervention in early stage breast cancer

Conditions: Breast Cancer; Fatigue; Insomnia; Pain

Summary: in order to determine the acceptability of a breast cancer-specific cognitive behavioral therapy intervention, as well as to obtain preliminary data to assess efficacy in managing symptoms, the investigators will ask 45 breast cancer survivors with moderate insomnia, fatigue, and/or pain to use the investigators' internet-based intervention for 8 weeks and to complete patient-reported outcomes assessments before and after the 8 week intervention.


Eligibility criteria:
inclusion criteria: * female * stage 0-iii invasive carcinoma of the breast * surgical resection and axillary assessment, radiation therapy, and/or chemotherapy, as indicated, completed at least 3 months prior to enrollment. * concomitant trastuzumab and anti-endocrine therapies are permitted. if taking anti-endocrine therapy must have been taking for at least 3 months prior to enrollment. * must report at least one of the following: 1. fatigue in the week prior to enrollment at least 4 on a 10 point scale (with 0 = not tired at all and 10 = extremely tired) 2. insomnia in the week prior to enrollment 3. pain in the week prior to enrollment at least 4 on a 10 point scale (with 0 = no pain and 10 = extremely severe pain) * has access to and is able to operate a computer with internet access. * able to read and understand english. * willing and able to sign an informed consent document. exclusion criteria: - diagnosis of sleep apnea or restless leg syndrome that is currently interfering with sleep
hemoglobin trend in neonates and toddlers post cardiac surgery

Conditions: Congenital Cardiac Defects

Summary: many toddlers and children are released home with relatively low hemoglobin levels following cardiac surgery, and with no careful follow up, at an age at which anemia is common. at this age, breast milk and its substitute do not provide enough iron, and parents are not adherent enough to iron supplements. due to these facts, there is high importance, especially in children suffering from heart defects, for close follow up on their hemoglobin levels. studies following hemoglobin trend post cardiac surgery were never done with children.

for the past 6 decades, children have been going through cardiac surgery to correct congenital heart defects. over the years, there has been great improvement in morbidity and mortality post cardiac surgery due to better technical skill and post operative treatment. most of those surgeries require cardio-pulmonary bypass machine, which requires the use of blood products, and many of those children also require blood product as part of the post operative care, especially those children with cyanotic heart defects. many toddlers and children are released home with relatively low hemoglobin levels, and with no careful follow up, at an age at which anemia is a risk factor for developmental delay and decreased cognitive function. iron deficiency is common in israel among children aged 6-24 months. at this age, breast milk and its substitute do not provide enough iron, and parents are not adherent enough to iron supplements as recommended by the ministry of health. due to these facts, there is high importance, especially in children suffering from heart defects, for close follow up on their hemoglobin levels. in adults, a study following hemoglobin levels post cardiac surgery during hospitalization only, showed that most (79%) starting showing improvement during their hospitalization. another study in patients over the age of 50 post coronary artery bypass graft, showed no difference between a group receiving iron supplements and another not receiving any, after 2 months. similar studies were never done with children.

Eligibility criteria:
inclusion criteria: * all children 0-18 months going through cardiac surgery during the 3 years of the study, after obtaining written consent from the parents/legal guardians. exclusion criteria: * none
pens or tens for pain in pancreatic cancer

Conditions: Pain; Cancer Pain; Pancreatic Cancer

Summary: this study evaluates the effect of percutaneous electrical nerve stimulation (pens) and transcutaneous nerve stimulation (tens) for pain relieving in patients with pancreatic cancer. patients will randomly allocated into pens group, tens group and control group.

pens and tens have been reported with analgesic effect in patients with pain, including cancer pain, lower back pain, neck pain, stomachache and so on. effect and mechanism of pens on pain relieving has been widely researched. with additional electrical stimulation in certain frequency and intensity to conventional acupuncture, pain controlling effect has been largely enhanced. however, invasive operation limits its application and acceptability, especially on pancreatic cancer. tens is an advanced technique generated from pens, which is much more welcome for its noninvasive character. further more, its analgesic effect on cancer pain has been proved by several multi-central, randomized, clinical trials.

Eligibility criteria:
inclusion criteria: * pancreatic cancer with pain; * haven't underwent neurolytic celiac plexus block in the past 1 month; * with anticipatory survival of more than 3 months. exclusion criteria: * metastatic pancreatic cancer; * can not tolerate 30 min of lieing in prostrate or side position; * ps\>3; * who has been recruited in other clinical trial for pain releiving; * who underwent radiotherapy or local radiactive seeds implantation for pain releiving in the past month; * imaging diagnosed with encephalic tumor or metastasis; * who with cardiac pacemaker or metal stand;

Keywords: percutaneous electrical nerve stimulation transcutaneous electrical nerve stimulation pain pancreatic cancer
a randomised feasibility trial with internet based self-help therapy

Conditions: Anxiety

Summary: background. in denmark, about 350,000 persons suffer from anxiety. public health-care services plan to implement internet based self-help psychotherapy (ibt) to be an important alternative and supplement to ordinary face-to-face therapy. meta-analyses indicate that the effect of ibt for anxiety disorders seems better than no intervention, and in some instances equal to 'usual therapy'. but studies have been characterised by small sample sizes, high risk for bias, including high dropout. objective. the objective of this pilot trial is to assess the feasibility of conducting a larger confirmatory trial investigating the benefits and harms of an internet-based self-help therapy program, fearfighter™, compared with no intervention for persons with an anxiety disorder. design. an investigator-initiated feasibility randomised clinical trial investigating internet-based therapy with fearfighter™ compared with no intervention for persons with an anxiety disorder. we will include 64 participants. eligibility criteria. inclusion criteria: age 18 or older; specific phobia, panic disorder, agoraphobia, or social phobia is the primary diagnosis according to the dsm-iv; and informed consent. exclusion criteria: suicidal risk; ongoing episode of bipolar disorder or psychosis; concurrent psychological treatment for the anxiety disorder; unable to attend the intervention; or lack of informed consent. intervention. the intervention group will use the program fearfighter™, a nine session cognitive behavioural self-help therapy program delivered over the internet during nine weeks. the control group receive no intervention for nine weeks. outcomes. feasibility outcomes are the fraction that are eligible, the fraction that are randomised, and the compliance in the intervention group. clinical exploratory outcomes are: remission, beck anxiety inventory, symptom check list-90r, who well-being index, sheehan disability scale, serious adverse events, and behaviour log from fearfighter. time schedule. participants will be included in the trial from july 2015. results are expected in february 2016.


Eligibility criteria:
inclusion criteria: * age 18 or older. * specific phobia, panic disorder, agoraphobia or social phobia is the primary diagnosis according to the dsm-iv * written informed consent. exclusion criteria: * acute suicidal risk. * ongoing episode of bipolar disorder or psychosis. * receive concurrent psychological treatment for an anxiety disorder * considered unable to attend ibt sessions as planned (due to vacation, work/study placement, sickness or similar occurrences). * lack of informed consent.

Keywords: anxiety behaviour therapy computer assisted therapy psychotherapy
vargado - vargatef in 2nd-line therapy of non-small cell lung cancer (nsclc)

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: this observational study will investigate the efficacy and tolerability of vargatef (nintedanib) plus docetaxel in daily routine second-line treatment in patients with locally advanced, metastatic or locally recurrent nsclc. treatment with vargatef in eligible nsclc patients, for whom the treating physician has decided to initiate treatment with vargatef in second line according to the local label, will be observed for up to 24 months. survial follow-up will be done until the end of the study.


Eligibility criteria:
inclusion criteria: * age 18 or older * men and women locally advanced, metastastic and/or recurrent nsclc with adenocarcinoma histology for which vargatef treatment is indicated according to summary of product characteristics (smpc) * after first line chemotherapy. this includes also combinations of immune- and chemotherapy. * standard 21-day-cycles docetaxel treatment according to smpc possible * written informed consent exclusion criteria: * contraindications according to the smpc of vargatef or docetaxel * more than one chemotherapy for treatment of nsclc in palliative setting * current partcipation in a clinical trial * pregnancy * breastfeeding