Kornimate/medical-research-clean huggingface dataset:
intravesical bcg: is the urinary bladder ready to receive it

Conditions: Non-Invasive Bladder Urothelial Carcinoma

Summary: prospective cohort and prospective observational study which aims to define the healing time-frame of the resected area of the bladder after turbt. and also to validate a grading system of healing of the bladder mucosa after turbt. to assess the factors influencing bladder healing is also one of the secondary objectives.

this study will be offered to patients who are coming to tata memorial hospital (tmh) for management of non muscular invasive bladder cancer. 10 patients who undergo transurethral resection of bladder tumour will be enrolled. any patient who undergoes turbt in tmh, found to have nmibc and gives consent is eligible for the study. patient who has visible tumor on first or any subsequent cystoscopy are not eligible. 100 patients (40 private category \& 60 general category patients) will be recruited, and they will be planned for cystoscopy in the minor operation theater under antibiotic cover and local anaesthesia at 2nd week, 3rd week, 4th week after the date of turbt. apprehensive or uncooperative patient will undergo procedure under general anaesthesia. patients having non healed bladder mucosa at 4 weeks will be reassessed after a further 1week by additional cystoscopy.each time of cystoscopy a photo of the healing resected area will be captured and will be used to compare with the next photo in the same patient to see the progress of healing. these photos will be assess by two experienced uro-oncologist to characterize the healing status of bladder.this comparison will be used to establish a grading system of bladder healing. the remaining cystoscopies will be performed as per guidelines. urine routine microscopy and culture/sensitivity will be done before every cystoscopy to rule out urinary tract infection and to quantify the numbers of white blood cells the wbc count will be correlated with the degree of inflammation and phases of healing as additional marker. patients who have healed or near healed resection area on any cystoscopy as per study protocol will be given ivb in the same setting if the patient is stratified as high risk nmibc. patients who will be stratified as low-risk nmibc and has healed resection area will not have further cystoscopy as per study protocol but will undergo cystoscopy later as per guideline's schedule. any patient having unhealed resection on cystoscopy will be planned for next cystoscopy as per protocol and ivb will not be given at this cystoscopy.

Eligibility criteria:
inclusion criteria: patients undergoing complete turbt for evaluation of a newly diagnosed bladder lesion in tmh and found to have nmibc (either low risk or high risk) patient gives consent will be included (after explaining about the study). exclusion criteria: 1. patient who has visible tumor on first or any subsequent cystoscopy. 2. on histopathology found to have muscle invasive bladder cancer. 3. patient having urinary tract infection before cystoscopy
efficacy and safety of human urinary kallidinogenase combined with endovascular therapy in acute ischemic stroke with large vessel occlusion

Conditions: Acute Ischemic Stroke

Summary: the purpose of this study is to evaluate the safety and efficacy of human urinary kallidinogenase combined with endovascular therapy in acute ischemic stroke (ais) patients with large vessel occlusion.

a prospective, randomized, double-blind, placebo-controlled, multi-center study of human urinary kallidinogenase or placebo, combined with endovascular therapy for ais patients with large vessel occlusion. approximately 120 eligible subjects will be randomized (1:1) to receive one of the following treatments for 10 days: * human urinary kallidinogenase combined with endovascular therapy (non-bridged) * placebo combined with endovascular therapy (non-bridged) primary efficacy of human urinary kallidinogenase will be evaluated at 90±7 days. the safety of human urinary kallidinogenase will be evaluated through 90±7 days. end of study evaluation will occur at day 90±7 or premature discontinuation.

Eligibility criteria:
inclusion criteria: 1. participant with acute anterior circulation ischemic stroke receiving endovascular treatment within 24 hours (non-bridged). 2. age ≥18 years old. 3. the mrs score was 0-1 before onset. 4. aspect score of infarction on emergency ct ≥7. 5. emergency cta indicating ais with large vessel occlusion (internal carotid artery, m1 or m2 segment of middle cerebral artery). 6. emergency ctp or dwi suggesting infarct core body ≥10 ml and \ 1.2. 7. participant is willing and able to comply with the study protocol, and sign the informed consent form (patient or surrogate). exclusion criteria: 1. participant with severe heart, liver and kidney dysfunction, coagulation dysfunction, intolerance to surgery, human urinary kallidinogenase allergy, contrast agent allergy or other angiographic contraindications. 2. ct or mri showed intracranial hemorrhagic diseases (such as hemorrhagic stroke, epidural hematoma, intracranial hematoma, intraventricular hemorrhage, subarachnoid hemorrhage, etc.). 3. participant with previous cerebral hemorrhage, brain tumor, brain trauma or other brain diseases. 4. taking acei antihypertensive drugs regularly and could not stop. 5. participant with major surgery or severe trauma in the past 2 weeks. 6. poor compliance and cannot fully follow the study protocol. 7. pregnancy or lactation.
comparison of cold and hot snare resection for colorectal polyps sized 10-19mm.

Conditions: Colonic Polyps/Colonoscopy/Colorectal Neoplasms

Summary: patients who met the criteria for removal of 10-19mm colorectal polyps using cold snare or hot snare were included in the study, signed by endoscopic treatment written informed consent for surgery, patients with detailed tracking and record the basic information and information related to the operation, postoperative lack of region and edge endoscopic observation carefully no residue, additional excision may be took if necessary，after resection specimen inspection, and in 6 months review colonoscopy, assess whether there is residual or recurrence of polyps.main outcome: technical success rate (no other auxiliary resection), complete resection rate, secondary outcome: intraoperative and postoperative complications, polypectomy time and related costs, influential factors of incomplete resection.research significance: the effectiveness, safety and cost-effectiveness of cold and hot snare resection of 10-19mm colorectal polyps were compared, and the influencing factors of incomplete polyps resection were analyzed, so as to provide evidence for the decision on the best method of medium-size polyps resection.


Eligibility criteria:
inclusion criteria: 1. colorectal polyps sized 10≤ diameter ≤19 mm; 2. boston bowel prepare score: 5-9; 3. the patients all signed the informed consent of endoscopic treatment. exclusion criteria: 1. complicated with inflammatory bowel disease, p-j syndrome or familial polyposis; 2. complicated with malignant tumors; 3. polyp size is uncertain; 4. currently taking aspirin, warfarin or other anticoagulants.
electrical stimulation effect on ankle instability during walking in virtual reality setup

Conditions: Ankle Sprains; Ankle Instability

Summary: the purpose of the study is to investigate whether electrical stimulation to leg muscles and joints can help with balance in people with ankle instability. participants will be asked to walk on a treadmill in a virtual reality cave. they will receive light electrical stimulation at the legs to improve your balance. the virtual reality image will sometimes shift in unexpected ways to challenge your balance. during the session, we will conduct a series of clinical assessments, including tests of functional performance and balance. additionally, participants will be asked to fill out some questionnaires.


Eligibility criteria:
inclusion criteria: * age 18 - 39 years. * having at least one significant ankle sprain in the past year, which causes a minimum of one interrupted day of physical activity. * having a history of at least two ankle sprains or "giving way" sensations at the injured ankle and/or a history of general feeling of ankle joint instability associated with the fear of getting another acute ankle sprain. * score \ 11 in the identification of functional ankle instability (idfai), and/or answer ''yes'' to at least 5 yes/no questions in the ankle instability instrument (aii). exclusion criteria: * any head, neck, or face injury in the six months prior to the study (e.g., concussion, eye injury). * history of vestibular or ocular dysfunction. * currently taking any medications affecting balance (i.e. antibiotics). * history of injuries to lower extremities including fractures, knee injuries, and hip injuries. * sustaining an ankle sprain injury in the last 6 weeks. * pregnancy * any neurological disorders (e.g., seizure disorders, closed head injuries with loss of consciousness greater than 15 minutes, cns neoplasm, history of stroke) * unstable cardiac or pulmonary disease. * clinically obese (bmi 30 or above). * any metal implant in the feet or legs that is close to the stimulating electrodes. * a known allergy to medical-grade adhesives. * any other comorbidity affecting the ability to safely walk without assistance for at least 2 minutes

Keywords: chronic ankle instability electrical stimulation virtual reality balance locomotor control
exer-gaming on upper extremity function and activities of daily living in sub-acute stroke patient.

Conditions: Stroke; Cardiovascular Stroke; Cerebrovascular Accident

Summary: stroke is one of the leading cause of death, in adult stroke causes permanent disability. stoke impact the life of a person significantly including the quality of life of an individual and especially performing the task of daily activities independently. about 50% survival of stroke have daily life activity limitation which is affecting their quality of life. among stroke patients, 69% experience functional motor disturbance in their upper extremity. the aim of this study is to evaluate the effect of exer-gaming by using the xbox kinect game system on upper extremity motor functions and the ability to perform adls in sub-acute stroke. various treatment methods are used for the rehabilitation of stroke. this study will be a randomized controlled trial, used to compare the effectiveness of exer gaming on upper extremity function and activities of daily living in sub-acute stroke patient. subjects with sub-acute stroke meeting the predetermined inclusion \& exclusion criteria will be divided into two groups using simple random sampling technique. pre assessment will be done using fma \& sis measurements. subjects in one group will be treated with conventional therapy and exer gaming and the other will be treated with conventional therapy and activities training session. each subject will be received a total 18 treatment sessions, with 3 treatment sessions per week for 6 weeks. post treatment reading for fma and sis will be recorded after the end of treatment session. recorded values will be analyzed for any change using spss.


Eligibility criteria:
inclusion criteria: * 1) first stroke 2) patient of sub-acute stroke 3) both gender 4) between 45 to 65 years of age 6) total score of 19 or greater on the mini-mental state examination 7) no problems with auditory or visual functioning. exclusion criteria: * 1) patient with global aphasia, and blindness, 2) taking any prescribed drugs that could potentially affect physical function and balance (such as corticosteroids, antipsychotics or antidepressants) 3) uncontrolled blood pressure (htn) 4) cardiac conditions 5) history of seizure 6) any intervention other than conventional therapy 7) refusal to use a video game.
levobupivacaine and postoperative pain relief

Conditions: Postoperative Pain; Inguinal Hernia Unilateral

Summary: the study analysed direct levobupivacaine instillation in surgical wound and its effectiveness in postoperative pain control. half participants received 0,5 % levobupivacaine and the other half received 0,9% saline solution

inguinal hernia is one of the most common conditions that requires elective surgical repair in children. the issue of post-operative pain in children is important, particularly because the surgical intervention per se is a stressful experience, after which the level of stressors in the recovery period should be minimized. stress, including the pain in the postoperative period, could contribute to a delayed postoperative wound healing and recovery. also, untreated acute pain could interfere with cognitive function, immune response as well as lead to the development of chronic postsurgical pain. for this reason, it is vital to reduce the painful sensations over the postoperative period as much as possible. levobupivacaine is a long-acting local anesthetic. evidence from animal models and human volunteer participants showed that levobupivacaine has favourable effects on cardiovascular and central nervous systems. clinical studies have also showed that levobupivacaine has a very low risk of systemic toxicity. a combination of levobupivacaine with non-opioid analgesics could have a beneficial role in the postoperative recovery from inguinal hernia surgery in terms of pain relief. the purpose of this study was to examine the effectiveness of levobupivacaine instillation combined with the routine postoperative non-opioid analgesia in children who underwent inguinal hernia repair. it is very important for children to leave the hospital without additional support. instilled levobupivacaine applied directly to the wound, currently interrupting transmission of the painful stimuli from the site of major trauma. the dose of applied levobupivacaine in this study is 2 times lower than that administered for caudal block and 4 times lower than the maximum dose. analgesic effectiveness of this procedure is measured by the frequency of administration of a mixture of ibuprofen and acetaminophen over 24 hours after surgery, and duration of time between the administration of two doses.

Eligibility criteria:
inclusion criteria: * elective surgery * not having incarcerated hernia * not having previous surgeries requiring general anaesthesia american society of anesthesia scores i and ii * not having allergy to topical anesthetics, paracetamol, ibuprofen and/or general anesthetics, opioids or muscle relaxants exclusion criteria: * worsening of health status prior to surgery * parental withdrawal to study

Keywords: postoperative pain hernia children levobupivacaine instillation
efficacy of ons supplementation in hnc outpatient under treatment

Conditions: Head and Neck Cancer

Summary: a rct study to compare the efficacy of ons supplementation with standard dietary advice on nutritional outcome inhnc outpatients undergoing treatment in radiotherapy clinic. ithe study population are all adult hnc outpatients receiving radiotherapy with or without chemotherapy treatments at radiotherapy clinic,nci. selected patient will be randomized into control group and intervention group until each group have 20 subjects, where the total of sample will be 40 patients (in consideration of 50% dropouts) and data will be collected at baseline (prior to treatment), week 2, 4, and the final data will be at week 6 or final day of cancer treatment. study objectives are to determine the efficacy of ons supplementation in outpatient hnc undergoing treatment in radiotherapy clinic, nci, to determine nutritional outcome (weight loss and bmi, body composition, dietary intake, albumin and hemoglobin level), functional outcome (handgrip strength) and side effect outcome (nutrition impact symptoms) in hnc outpatients given intensive nutrition intervention with outpatients given routine care. this study also want to find association of intensive nutrition intervention versus routine care in nutrition outcome, functional and side effect outcome in both group. subjects in intervention group will received standardize ons supplementation every day during treatments once daily with frequent dietary advice accordingly to the patients condition while control group will received standard routine care which includes frequent dietary advice without supplementation of ons. study hypothesis is there is no significant difference in nutritional outcome, functional outcome and side effect outcome between hnc outpatients receiving ini when compared to hnc outpatient receiving routine care undergoing radiotherapy treatment. there is also no association between these two groups in nutritional outcome, functional outcome and side effect outcome.


Eligibility criteria:
inclusion criteria: 1. those who diagnosed with head and neck cancer (hnc) and receiving radiotherapy with or without chemotherapy treatments. 2. able to communicate. 3. patient admitted to ward less than 5 days. exclusion criteria: 1. patient on tube feeding. 2. patient was already on ons before study period. 3. patient already started treatments (referring to chemotherapy, radiotherapy and ccrt) before study period.
immunohistochemical evaluation of dna methylation and histone modification in h. pylori associated gastric carcinoma

Conditions: Gastric Carcinoma

Summary: the goal of this cross-sectional study is to evaluate epigenetic modifications in gastric carcinogenesis, mainly in h. pylori gastritis vs gastric carcinoma. the main question\[s\] it aims to answer are: * how does h. pylori infection cause gastric cancer? * can dna methylation and other epigenetic changes predict and affect the development of gastric cancer? formalin-fixed-paraffin-embedded tissue specimens will be obtained and reviewed for comparison between epigenetic changes in h. pylori gastritis and gastric adenocarcinoma.


Eligibility criteria:
inclusion criteria: * resected specimens and endoscopic guided biopsies of intestinal type gastric carcinoma, h. pylori associated gastritis, and non-h. pylori gastritis with: * available full clinical data: (age, sex, complaint, findings in clinical examination). * full data of previous endoscopy and radiology. exclusion criteria: * cases of diffuse type gastric carcinoma. * any case of gastric cancer, h. pylori associated gastritis, non-h. pylori gastritis, benign gastric lesions with missing clinical, endoscopic, radiologic or follow-up data. * cases with no available h\&e stained slides or formalin fixed paraffin embedded block.
lichtenstein versus tapp and tep in groin hernioplasty

Conditions: Inguinal Hernia

Summary: the aim of the study is to evaluate the effectiveness of various methods of inguinal hernia repair and to evaluate techniques of synthetic mesh fixation during laparoscopic and open hernia repair.

in modern literature there is no conclusive evidence for the superiority of endoscopic over open inguinal hernia repair techniques, due to the lack of prospective, multicenter, randomized studies involving a sufficient number of patients. both lichtenstein and tapp/tep techniques are widely used and accepted methods of treatment. the clinical significance of this study is to show the differences in the incidence of perioperative complications, the evaluation of postoperative pain, full recovery time and improving the quality of life. the diagnosis of inguinal hernia will be based on a physical examination performed by an experienced surgeon based on the medical history of the patient and, if necessary, on ultrasound examination of the abdominal wall. random assignment of patients to one of three treatment arms will take place the day before the surgery using computer-generated randomization list. the operating surgeon will be determined prior to randomization. each patient before the study will receive complete information about the study which will be explained in detail regarding all planned procedures, the patient will obtain answers to any questions. after explaining any doubts the patient will sign the informed consent to participate in the study, in the presence of the investigator. patients will be divided into three groups - tapp, tep and lichtenstein method. patients treated by tapp and lichtenstein will be further divided into subgroups - fixation glue or stitching - lichtenstein method; fixation glue, tackers or implantation without fixation - tapp method. patients will receive preoperative antibiotic prophylaxis with a single dose of cephalosporin. patients undergoing surgery will be hospitalized in the department of surgery until the first postop day. in justified cases, hospitalization will be extended.

Eligibility criteria:
inclusion criteria: * male * age: 18 - 65 * planned inguinal hernia repair using synthetic implant * bmi range: 20-35 kg / m2 * written informed consent exclusion criteria: * prior midline laparotomy * contraindications for general anaesthesia * asa \> iv * cirrhosis (child b or c) or ascites * active treatment with use of chemiotherapy * incarcerated hernia

Keywords: tapp tep lichtenstein syntethic mesh hernioplasty
clinical study to evaluate the long term efficacy, safety and tolerability of miglustat in patients with stable type 1 gaucher disease

Conditions: Gaucher Disease Type 1

Summary: although miglustat has been approved as a treatment for mild to moderate type 1 gaucher disease in patients who are unsuitable for enzyme replacement therapy (ert), more data are required to establish the long term efficacy, safety and tolerability of miglustat in maintaining diseases stability after a switch from ert.


Eligibility criteria:
inclusion criteria: 1. males or females aged 18 years or older 2. type 1 gaucher disease, diagnosed by glucocerebrosidase assay or molecular analysis of the glucocerebrosidase gene. 3. treatment with ert for at least 3 years, with a stable dose regimen for at least the last 6 months. 4. clinically and biologically stable disease for the previous 2 years, with at least 2 time points assessments (including baseline as one potential time point), defined as: * stable organomegaly (assessed by magnetic resonance imaging (mri) or computed tomography (ct)): * liver volume within 10% of the mean. * spleen volume within 10% of the mean. * free of progressive symptomatic documented bone disease. * hemoglobin levels \> 11g/dl * mean platelet count \> 100x10\^9 /l. * chitotriosidase activity within 20% of the mean. * if chitotriosidase is not available (in the case of chitotriosidase deficiency, or if it was not determined), other relevant biomarkers (e.g., angiotensin converting enzyme (ace), tartrate resistant acid phosphatase (trap) and ferritin) could be considered. 5. written informed consent. exclusion criteria: 1. history or evidence of oculomotor gaze palsy, ataxia or other clinical manifestations typically associated with neuronopathic type 3 gaucher disease. 2. not ambulant patients, or with progressive symptomatic documented bone disease. 3. splenectomy before 18 years of age for splenomegaly and/or thrombocytopenia. 4. peripheral polyneuropathy (not mononeuropathy) documented with both clinical signs and symptoms, and electrodiagnostic (edx). 5. patients (males and females) who do not agree to use reliable contraception throughout the study and for 3 months after cessation of miglustat treatment. 6. female patients who are pregnant or breast feeding, or without pregnancy test prior to day 1. 7. history of significant lactose intolerance. 8. clinically significant diarrhea (\>3 liquid stools per day for \>7 days) without definable cause within 6 months prior to day 1, or a history of clinically relevant gastrointestinal disorders. 9. history of cataracts or known increased risk of cataract formation. 10. severe renal impairment i.e., with a creatinine clearance \<30 ml/min/1.73m\^2 11. concomitant active medical condition such as human immunodeficiency virus (hiv) or hepatitis b/c that would render patients unsuitable for study. 12. previous treatment with miglustat.

Keywords: enzyme replacement therapy type 1 gaucher disease miglustat