Kornimate/medical-research-clean huggingface dataset:
the effects of oculomotor exercises and hands-on protocol in non-specific neck pain

Conditions: Neck Pain Musculoskeletal

Summary: this study aimed to evaluate the effectiveness of adding oculomotor techniques and hands-on treatments to routine exercise protocols for individuals with non-specific chronic neck pain (nscnp).

a randomized controlled trial was performed at the orthopedic rehabilitation clinic. ethical standards in the 1946 declaration of helsinki, as revised in 2013, were followed, and the university ethics board approved the study (approval number 147). this research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. the study was conducted with individuals aged 18-65 who applied to a private clinic, received a doctor's diagnosis, met the inclusion criteria, and voluntarily agreed to participate in the study. participants a total of 38 subjects were calculated as the minimum required sample size determined by power analysis, and 38 subjects aged 18 to 65 years with a diagnosis of nonspecific neck pain who met the inclusion criteria and voluntarily agreed to participate were included in the study. signed consent forms were obtained from the volunteers who agreed to participate in the study by face-to-face interview.

Eligibility criteria:
inclusion criteria: * the inclusion criteria included being between ages 18 and 65 old, having been diagnosed with nonspecific neck pain, being able to comply with exercise instructions and understand evaluation questions, and volunteering to participate in the research. exclusion criteria: history of acute or chronic musculoskeletal pain other than nonspecific neck pain, history of a rheumatological disease, sequestered or extruded disc herniation, having received physical therapy in the last three months, recent history of surgery, infectious and vascular diseases, and cooperation and communication problems presence were excluded.

Keywords: neck, non-specific neck pain, exercise, oculomotor exercises, myofascial release
targeted prostate biopsy using a novel mri-ultrasound fusion device

Conditions: Prostate Cancer

Summary: the purpose of this study is to evaluate the effectiveness of focal-fusion bx at detecting clinically significant prostate cancer in a standard clinical environment.

the objective of this study is to determine the effectiveness of the focal-fusion bx device at finding clinically relevant prostate cancer. a multiparametric mri examination will be carried out prior to study enrollment. probable cancerous regions (regions of interest, roi) will be identified, and these rois will be used as targets during the biopsy. three prostate sampling methods will be conducted in the same session on all patients. these include: i) focal-fusion bx targeted biopsy ii) cognitive fusion targeted biopsy and iii) systematic (untargeted) biopsy. trans-rectal ultrasound (trus) imaging will be conducted with bk flex focus ultrasound system (analogic corporation, peabody, ma). primary hypothesis: the technique used to acquire the biopsy samples will impact the proportion of clinically relevant cancers by improving the specificity of detecting clinically significant cancers. it is hypothesized that focal-fusion bx biopsies will diagnose more high risk cancers and fewer low-risk cancers than non-targeted systematic biopsies.

Eligibility criteria:
inclusion criteria: * adult male subjects up to 80 years of age * candidates for fusion biopsy * elevated psa levels * mp-mri with lesions having a prostate imaging reporting and data system (pi-rads) score greater than or equal to 3 (determined by a trained radiologist) * subject is willing and able to read, understand and sign the informed consent form document exclusion criteria: * previous treatment for prostate cancer * any contraindication to a standard trus prostate biopsy procedure * refusal to sign the informed consent document

Keywords: prostate cancer biopsy focal healthcare fusion targeted biopsy high risk cancer imaging diagnostic ultrasound multiparametric magnetic resonance imaging (mp-mri) mri-ultrasound fusion focal-fusion bx
congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis: predictive factors for transient vs permanent hypothyroidism.

Conditions: Congenital Hypothyroidism

Summary: in france, the incidence of congenital hypothyroidism has increased significantly since the newborn screening program was introduced in 1978. the largest increase is seen in children with eutopic thyroid gland. more than one-third of children with eutopic gland have transient hypothyroidism. clinical practice guidelines recommend to re-evaluate thyroid function in children with eutopic gland around the age of 3 years to determine whether hypothyroidism is transient or permanent. up until today it is still difficult to determine early on whether hypothyroidism is transient or permanent in children with eutopic gland. our aim is to identify one or more predictive factors for transient congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis.


Eligibility criteria:
inclusion criteria: * children with congenital hypothyroidism * eutopic thyroid gland or thyroid hemiagenesis * born between 1996 and 2017 * treated at the nancy regional and university hospital * follow-up of at least 3,5 years. exclusion criteria: * polymalformative syndrome * thyroid dysgenesis except for thyroid hemiagenesis

Keywords: eutopic thyroid gland transient hypothyroidism
metabolic effects of whey compounds in patients with diabetes mellitus type 2.

Conditions: Diabetes Mellitus, Type 2

Summary: the main objective of our study is to investigate the metabolic effects of a i) ordinary whey protein (whe) and ii) a specific whey protein fraction (spewhe) when the interventions are ingested by patients with type 2 diabetes 30 minutes prior to an oral glucose tolerance test (ogtt). we will also investigate the glucose response when the patients ingest the interventions at home in their own environment 30 minutes before breakfast and dinner (2days) and also monitor glucose levels without interventions (2 days).


Eligibility criteria:
inclusion criteria: * age \> 18 years * type 2 diabetes (t2d) diagnosis * no medical treatment or metformin/sulfonylureas(su) alone in the treatment of t2d * no daily use of protein drinks * hba1c between 40 mmol/mol and 69 mmol/mol * 20 kg/m2 \< bmi \< 35 kg/m2 * screening blood test: 1200 pmol/l \> c-peptid \> 370 pmol/l exclusion criteria: * other diabetes medication than metformin/su (e.g. insulin, glp-1 analog, dpp-4 inhibitor, sglt2-inhibitor) * affected screening blood test assessed by the primary investigator(pi)/sponsor * does not understand or speak danish * milk allergy * pi finds the patient not fit (e.g. mental illness, too nervous or other)
lateral occlusion of uterine artery in total laparoscopic hysterectomy

Conditions: Postoperative Hemorrhage

Summary: laparoscopic hysterectomy is associated with complications in form of infections and subsequently dehiscence of the vault. this is a serious complication. the infection may be related to the frequently observed postoperative hematoma following traditional laparoscopic hysterectomy where the uterine artery is coagulated and divided at the cervical entry into the uterus. by coagulation of the uterine artery laterally close to the internal iliac artery this problem may be eliminated due to the much less bleeding observed during this procedure.

laparoscopic hysterectomy (removal of the uterus) is today a well-described method for the removal of the uterus. the operation is offered in case of bleeding disorders where other treatments have been unsuccessful, uterine fibroids or other conditions requiring surgery with removal of the uterus. the operation is done today in most cases by dividing the uterine artery at the entrance to the cervix, where the artery divides into one ascending and descending branch. the most common complication of hysterectomy is bleeding perioperative well as postoperatively, which may result in a hematoma above the vaginal vault. through the years different methods have been tried to reduce this complication, including tranexamic acid without great success. the hematoma may result in infection postoperative and subsequent poor healing, with the possibility of dehiscence of the vault. in the worst case, the gut is displaced through the vagina postoperatively. this condition can lead to diffuse peritonitis, which can be fatal in rare cases. since the hemostasis related to the dividing of the artery uterine can be problematic, especially in case of fibroids it may be a technical advantage to coagulate the uterine artery at the exit of the internal iliac artery. this operation also ensures identification of the ureter, which can be spared. lesions to the ureter are detected in up to 1% of all surgical procedures at hysterectomy. dividing of the uterine artery at the internal iliac artery also ensures that the artery can be divided with minimal bleeding at the cervix.

Eligibility criteria:
inclusion criteria: * women submitted to total laparoscopic hysterectomy exclusion criteria: * women \<18 years * women no able to understand the study or not native in danish * women with uterine malignancy * women with suspicion of pelvic mass * women with abnormal coagulation * women receiving glucocorticoid treatment * women receiving anticoagulant treatment or have not followed prescription in relation to surgery

Keywords: hematoma complication hysterectomy
probiotics to improve women's health

Conditions: Healthy

Summary: the purpose of the study is explore the effect of probiotics on plasma lipopolysaccharides (lps) concentrations, as well as insulin and glucose levels, in obese women prior to and after dietary challenges (high carbohydrate meal, high fat meal).


Eligibility criteria:
inclusion criteria: * bmi=30-40 kg/m2 * healthy, age 18 or older * not consuming yogurt or cultured milk regularly (\</= 1x/wk) or any probiotic supplement exclusion criteria: * medical conditions or medications that may affect metabolism as determined by the pi.

Keywords: healthy obese women
predicting rupture of aaa by anatomic and hemodynamic markers

Conditions: Aortic Aneurysm, Abdominal

Summary: the purpose of the study is to investigate imaging findings, which can help us to predict factors contributing to abdominal aortic aneurysm growth and rupture.


Eligibility criteria:
inclusion criteria: * individuals between 18 and 80 years old receiving medical care at university of minnesota medical center who have a normal aorta cta within the previous year * or patients with known aaa with growth rate of 0-0.2 cm/year * or patients with known aaa with growth rate of greater than 0.5 cm/year. exclusion criteria: * subjects with ferromagnetic implants * penile implant * hip replacement * history of shrapnel or shot gun injury * body mass index ≥ 30 * cardiac pacemakers * severe claustrophobia * large tattoos on the torso
a pilot study to evaluate the feasibility and potential effectiveness of the flexitouch system head and neck treatment

Conditions: Head and Neck Neoplasms; Head and Neck Cancer; Head and Neck Lymphedema

Summary: the study will evaluate the feasibility and potential effectiveness of the flexitouch head and neck treatment plus standard home care compared to standard home care regimen alone.

this study is an open-label, multi-site, stratified randomized, wait list control, pilot study. the study will be conducted at up to 2 sites in the united states and enroll 40 subjects with a diagnosis of head and neck lymphedema following treatment for head and neck cancer. subjects randomized to receive daily treatment with the flexitouch pneumatic compression device and home care regimen (soc) will be seen at baseline and weeks 1, 4, and 8. subjects randomized to the wait list arm will be seen at baseline and weeks 1, 4, and 8 while receiving soc treatment. assessments will include fidelity, satisfaction, symptoms, swelling/inflammation, function, and qol.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * a previous diagnosis of histologically defined head and neck cancer. * a diagnosis of head and neck lymphedema. * must be able and willing to participate in all aspects of the study and provide informed consent prior to study participation. * completed cancer treatment with no evidence of active cancer; all post-surgical swelling must be resolved. * the head and neck garments must fit appropriately. for patients with a tracheostomy, the fit will be assessed to ensure that the garments do not interfere with their tracheostomy. * the subject must have experienced at least one of the following: * completion of phase 1 lymphedema care in the past 8 weeks; * the inability to participate/complete phase 1 care due to: * lack of available therapist/clinic, * lack of insurance coverage or funding to support cost of care. exclusion criteria: * uncontrolled hyperthyroidism or parathyroidism (for which endocrinologist recommends against neck compression). * carotid sinus hypersensitivity syndrome. * symptomatic carotid artery disease, as manifested by a recent transient ischemic attack (within 30 days), ischemic stroke, or amaurosis fugax (monocular visual ischemic symptoms or blindness). * symptomatic bradycardia in the absence of a pacemaker. * internal jugular venous thrombosis, acute or within 3 months. * increased intracranial pressure or other contraindications to internal or external jugular venous compression. * acute radiation dermatitis, unhealed surgical scar, unhealed or open wound(s), surgical flap less than 6-8 weeks post-operative. * facial or head and neck dermal metastasis. * acute facial infection (e.g., facial or parotid gland abscess). * any condition in which increased venous and lymphatic return is undesirable. * history of pulmonary edema or decompensated congestive heart failure with in six (6) week of enrollment. * subject is pregnant or trying to become pregnant.

Keywords: lymphedema cancer head cancer neck cancer head and neck cancer
comparing intrathecal morphine with modified thoracoabdominal nerve block through perichondral approach in major abdominal surgery

Conditions: Opioid Use; Postoperative Pain

Summary: abdominal surgery causes severe postoperative pain due to retraction of the abdominal wall and direct manipulation of visceral organs. it leads to delayed postoperative recovery, increased postoperative morbidity and mortality. intrathecal morphine, epidural analgesia and patient-controlled intravenous analgesia are used in postoperative pain management of abdominal surgeries. intrathecal morphine is frequently used in many centers because it provides effective pain control. however; morphine has undesirable effects such as urinary retention, postoperative nausea and vomiting, and respiratory depression. modified thoracoabdominal nerves block through perichondrial approach is a technique defined by the modification of the thoracoabdominal nerves block through perichondrial approach, in which local anesthetics are delivered only to the underside of the perichondral surface. the primary implication of this study is to compare postoperative pain scores and opioid consumption in patients undergoing major abdominal surgery with intrathecal morphine or modified thoracoabdominal nerves block through perichondrial approach.


Eligibility criteria:
inclusion criteria: * patients over 18 years old * patients undergoing major abdominal surgery exclusion criteria: * patients with solid organ dysfunction * patients who receive opioid or corticosteroid medication prior to surgery * patients with bleeding diathesis * patients with psychiatric disorders * patients who can not be contacted after surgery

Keywords: intrathecal morphine modified thoracoabdominal nerve block through perichondral approach
dual antiplatelet therapies for prevention of periinterventional embolic events in tavi

Conditions: Aortic Valve Stenosis; Transcatheter Aortic Valve Replacement; Intracranial Embolism

Summary: tavi is increasingly adopted as standard treatment for many subgroups of patients with aortic stenosis. however, due to a lack of data there is yet no tavi-specific guidance regarding the optimum periinterventional drug regimen. the study evaluates the effect of dual antiplatelet pretreatment on periinterventional embolic cerebral lesions and bleeding complications in patients undergoing transfemoral aortic valve implantation (tf-tavi).

patients undergoing tavi bear a high risk of ischaemic stroke, which is an independent predictor of mortality1. dual antiplatelet therapy (dapt) is recommended by current guidelines without clear specifications on the time of initiation of treatment due to a lack of data. while some centers initiate dapt with aspirin and clopidogrel prior to tavi to reduce the rate of periinterventional embolic events, others start these medications after the procedure.data on antithrombotic therapy during tavi are scarce and no randomized evaluation has been performed to demonstrate what the best strategy is during the procedure. therefore, the objective of this clinical trial is to assess the efficacy of pre- versus postoperative dual antiplatelet loading with aspirin and clopidogrel on volume of periinterventional cerebral ischemic lesions as quantified by diffusion weight mri (dw-mri) and neurocognitive function in patients undergoing transfemoral aortic valve replacement. the statistical trial design assumes superiority of preloading with dapt regarding the primary endpoint.

Eligibility criteria:
inclusion criteria: * patients \>18 years and \<90 years * patients undergoing tf-tavi for severe aortic stenosis (combined with aortic regurgitation) * informed consent exclusion criteria: * tia/stroke within last 90 days * aortic valve-in-valve procedures * tavi for treatment of isolated aortic regurgitation * known significant carotid stenosis (\>70%) * prior myocardial infarction or revascularization with pci or cabg within past 3 months * clopidogrel and/ or aspirin within past 7 days * any other indication for (dual) antiplatelet therapy * contraindication to mri (mri conditional pacemakers accepted!) * participation in another interventional trial * cardiogenic shock (positive shock index or need for catecholamine support or systolic bloodpressure \< 90 mmhg) or need for pre-hospital intubation * cardiac arrest \<90 days prior to randomization * pregnant or lactating females
comparing gabapentin and amitriptyline for the treatment of neuropathic pain in children and adolescents

Conditions: Pain

Summary: the objective of the study is to compare the efficacy of gabapentin and amitriptyline for treating neuropathic pain in children in a randomized controlled trial.

clinical experience and case reports suggest that both amitriptyline and gabapentin are effective treatments for neuropathic pain in children; however we do not know which drug is more effective for specific pain conditions or for specific children. this study will be the first prospective, randomized double-blind controlled trial directly comparing gabapentin and amitriptyline for the treatment of neuropathic pain in a paediatric population. we will also study the time course for pain reduction and evaluate changes in children's physical function, mood, and sleep. this information is needed to determine which drug is better for which children and which pain conditions.

Eligibility criteria:
inclusion criteria: * 8 - 17 years of age * diagnosis of neuropathic pain exclusion criteria: * additional health problems * lactose intolerant * unable to swallow size 0 gelatin capsules * pregnant * unable to speak english

Keywords: pain analgesia gabapentin amitriptyline pediatrics
comparison of the non-invasive biobeat device with an invasive arterial line

Conditions: Blood Pressure; Heart Diseases

Summary: in this clinical study the investigators will compare blood pressure measurements obtained using the non-invasive, continuous and wireless biobeat monitoring device (a wrist watch or a patch configuration) to an invasive arterial line (radial or femoral) in 30 patients immediately after cardiac surgery, at the intensive care unit.

the biobeat non-invasive, continuous and wireless monitoring device is based on photoplethysmograph technology. it measures several vital signs, including blood pressure, stroke volume, pulse rate, pulse pressure, heart rate variability, respiratory rate, saturation, cardiac output, cardiac index, and more. the data is transmitted to biobeat's application (in both apple and google play), and is available on the individual's cellular phone, tablet, or as a full monitoring system in a hospital department. the aim of this study is to compare the biobeat monitor with the invasive method of blood pressure measurement, an arterial line. the study population includes 30 patients undergoing cardiac surgery. as per local protocol, each one of the participants will come out from the operating room with an arterial line. once in the intensive care unit, the investigators will attach the biobeat non-invasive monitor (either wrist watch or a patch, these two configurations are identical in terms of the monitoring system), and monitor the participants for 4 hours. though both methods are continuous, the investigators will record the vital signs every 15 minutes during the 4 hours of the study.

Eligibility criteria:
inclusion criteria: * patients arriving immediately after cardiac surgery to the intensive care unit with an arterial line. exclusion criteria: * refusal to participate * patients with no arterial line * pregnant women * individuals under the age of 18 years * patients with lack of judgment/mental illness * patients working in the baruch padeh medical center

Keywords: vital signs blood pressure cardiac surgery non-invasive monitoring