Kornimate/medical-research-clean huggingface dataset:
knee related subchondral bone lesions treated with iobp

Conditions: Subchondral Cyst

Summary: the study will be a prospective, multicenter clinical study evaluating clinical and patient reported outcome measures of subjects receiving iobp® surgical technique using angel cprp and bma processing system to treat subchondral bone pathology (sbp).

the study will be a prospective, multicenter, clinical study, enrolling both male and female patients. subjects will be identified among the investigators' patient population scheduled for the iobp® procedure and as being diagnosed with symptomatic sbp that have failed conservative management. irb approval will be obtained by each participating institution. the primary outcome measure is adverse event evaluation to determine whether iobp® can prevent further surgical intervention (i.e., knee replacement surgery, hto, or calcium phosphate stabilization of sbp) when used to treat symptomatic sbp of the knee.

Eligibility criteria:
inclusion criteria: 1. able to read, understand, sign and complete informed consent 2. male or female subject between the ages of 18-60 years 3. subject has had pain for greater than three months 4. subjects with single sbp in tibia or femur confirmed by minimum 1.5t mri (including coronal, axial, sagittal, lateral femur, and lateral tibia views) and are candidates for an iobp® procedure 5. subject has stable ligaments 6. subject has neutral alignment (max 5° varus or valgus) 7. subject has a vas score greater than or equal to five 8. subject is scheduled to undergo surgical intervention using iobp® exclusion criteria: 1. subject has diabetes type i, type ii uncontrolled, or type ii insulin dependent 2. subject has had lower extremity surgery within six months 3. subject has had more than two prior surgical procedures in the operative leg 4. subject has a neuromuscular condition 5. subject has a current infection 6. subject has a bmi \>35 7. subject has subchondral bone collapse or kellgren lawrence grade iv osteoarthritis 8. subject has joint surface collapse in late stage avascular necrosis 9. subject has majority of pain associated with alternate conditions 10. subject has had subchondral bone pathology caused by acute trauma 11. subject is not neurologically intact. 12. subject has history of invasive malignancy (except non-melanoma skin cancer) 13. subject that has a planned or scheduled additional surgery within the course of the study (lower extremity) 14. subject has an active substance abuse problem 15. subject is currently taking narcotic pain medication 16. subject is pregnant or planning to become pregnant 17. subject is on worker's compensation 18. subject has a concomitant procedure not including meniscectomy, synovectomy, chondroplasty, or removal of loose body 19. inability to complete study requirements and follow-up visits 20. subject that has a bone marrow aspiration that does not meet 60cc
outcome after surgical reconstruction of the achilles tendon insertion.

Conditions: Achilles Tendinopathy; Insertional Achilles Tendinopathy

Summary: the purpose of this study is to evaluate the functional outcomes and sports ability after surgical treatment of insertional achilles tendon tendinopathy using tendon detachment, debridement, and double-row anchor refixation.

the lifetime risk of achilles tendon pain is approximately 6%, one-third of whom complain of pain at the bony attachment of the achilles tendon to the calcaneus. primary treatment of these insertional tendinopathies is always nonsurgical with physical therapy, orthotics, shock wave therapy, or various forms of injections. if there is no response to therapy, surgery is warranted after three to six months. in this procedure, the tendon is detached from the bone, the damaged portions of the tendon are removed, bony prominences are rounded, and finally the tendon attachment is reconstructed and fixed with anchors. various anchor systems are available for this purpose. the double-row anchor system used by the investigators in recent years allows stable, knotless, two-dimensional refixation of the achilles tendon to the calcaneus and thus permits rapid rehabilitation. recent studies show good functional results 33 months after reconstruction of the achilles tendon attachment with the "speed bridge" system. to the best of our knowledge, however, there are no studies to date on sports ability after this operation. the investigators are therefore conducting a retrospective collection of clinical patient data combined with a planned (prospective) questionnaire survey of patients with insertional achilles tendon tendinopathy who received surgical treatment with tendon refixation.

Eligibility criteria:
inclusion criteria: * all patients who underwent reconstruction and double-row anchor refixation of the achilles tendon insertion due to an insertional tendinopathy of the achilles tendon. exclusion criteria: * lack of informed consent * revision surgery * patients who had another operation on the same leg during the same procedure or 6 months later

Keywords: insertional achilles tendinopathy surgery sport
remote monitoring and detecting of tardive dyskinesia for improving patient outcomes

Conditions: Tardive Dyskinesia

Summary: the study is being conducted to validate the feasibility of remote assessment of tardive dyskinesia.

the study is being conducted to validate the feasibility of remote assessment of tardive dyskinesia. participants will all be taking an antipsychotic medication and half will have a diagnosis of tardive dyskinesia and half will not. participant responses to interview questions and elements of the abnormal involuntary movement scale will be collected on video. the videos will be rated by trained observers. machine learning methods will be used to develop an algorithm to detect abnormal movements in individuals with a known tardive dyskinesia diagnosis. the trained rater results will be compared to the algorithm to determine the accuracy of the algorithm.

Eligibility criteria:
inclusion criteria: for the non-td group: 1. prescribed and taking an antipsychotic medication for 90-days or longer. 2. tardive dyskinesia symptoms if present are not from parkinsons, tourette's syndrome, huntington disease. 3. signed an informed consent. 4. speaks english fluently. exclusion criteria: 1. suffered a moderate or severe head injury in the last year; 2. history of a learning disorder or developmental disability that would inhibit a patient from completing the td protocol. 3. severe visual impairment that is cannot be corrected by glasses or contacts.
anterior cruciate ligament (acl) revision surgery: french national study

Conditions: Anterior Cruciate Ligament Rupture

Summary: this is a national multicentric study led by the french arthroscopy society (sfa) evaluating clinical practice in anterior cruciate ligament (acl) revision surgery (epidemiological data, morphological data, operative data, clinical and functional outcomes, and surgical complication rates).


Eligibility criteria:
inclusion criteria: * patient with an anterior cruciate ligament (acl) revision, defined as "all surgical procedures involving replacement of the anterior cruciate ligament (acl) graft with a new graft". exclusion criteria: * multil-igament injuries * any procedure where the acl was not revised and where any additional graft was inserted * patients who had already undergone their first revision anterior cruciate ligament (acl) procedure

Keywords: knee acl revision surgery
a randomized control trial of narrative exposure therapy versus treatment as usual in the therapy of borderline personality disorder

Conditions: Posttraumatic Stress Disorders; Borderline Personality Disorders

Summary: definition of the efficacy of net compared with "treatment as usual" in the treatment of patients with complex traumatic disease (borderline personality disorder (bpd) and posttraumatic stress disorder (ptsd)) as assessed by structured clinical interviews. furthermore, to evaluate the sleep, cortisol level and epigenetic differences in the process of the specific therapy compared to treatment as usual.

experimental intervention: narrative exposure therapy (net), an evidence-based trauma-focussed treatment, suitable for survivors of prolonged and repeated exposure to traumatic stress and childhood adversity. control intervention: treatment as usual. follow-up per patient: 3 follow-up assessments- 4 weeks, 6 months,12 months and 24 months after end of experimental/ control intervention duration of intervention per patient: both treatment types will be conducted for 10-14 sessions of 60-90 min in length. additionally 5 sleep laboratory investigations (1 pre- and 4 post- intervention (4 weeks, 6 months, 12 months, 24 months after treatment)) will be carried out. additionally the cortisol level in the hair and epigenetic markers will be recorded. the estimated observation time is 2 years.

Eligibility criteria:
inclusion criteria: * dsm-iv -tr diagnosis axis ii: borderline personality disorder; axis i: posttraumatic stress disorder * stable medication * age 18-45 years, gender female * legal competence * sufficient cognitive function * sufficient knowledge of the german or english language exclusion criteria: known severe internal, neurological, musculoskeletal, endocrinological or sleep disorders with organic origin (clinical examination during the screening visit, judged by the investigator) * gravidity (positive ß-hcg test) * continuing and not interruptible exposure to sexual or physical abuse * acute suicidal tendency * positive drug-screening in urine toxicology test

Keywords: psychotherapy ptsd borderline personality disorders
mins, aki and pulmonary pathology in patients undergoing acute abdominal surgery

Conditions: Abdomen, Acute; Myocardial Injury; Acute Kidney Injury; Pulmonary Disease

Summary: explorative study to investigate potential predictors of myocardial injury, acute kidney injury and pulmonary disorder after acute high-risk abdominal surgery.

the main issues are: * to investigate if coronary calcification predisposes the development of myocardial injury and causes an increased mortality rate. * to evaluate the predictive value of nt-pro-bnp in relation to the development of mins and the mortality rate. * to evaluate the predictive value of different biomarkers of aki in relation to which patients develop aki. * to examine the proteins, exosomes and single cell rna during acute kidney injury in order to describe the molecular processes in the kidney during aki. * to examine whether a chest ct scan without contrast enhancement will change treatment decisions in the acute gastrointestinal patient compared with a chest x-ray.

Eligibility criteria:
inclusion criteria: * adults (≥18 years). * patients included in the aha regimen undergoing ct on suspicion acute high-risk abdominal disorder e.g.g bowel obstruction gi perforation or ischemia, and need of emergency abdominal surgery, either laparoscopic surgery or laparotomy. * able to speak danish. in case danish was not spoken an interpreter was used to obtain the informed consent. * able to give informed consent. exclusion criteria: * patients who cannot give informed consent to participate in the study 15 minutes after receiving verbal information regarding the study. * known chronic kidney disease requiring dialysis at the time of admission (only exclusion criteria for the part of the study relating to aki). * patients included in the aha regimen, but conservative treatment is chosen (only exclusion criteria for the part of the study relating to mins and aki). * patients not resident in denmark. * patients not able to give informed consent. * patient not able to speak danish and not enough time to obtain an interpreter.
eccentric exercise in treatment of achilles tendinopathy

Conditions: Achillodynia

Summary: the purpose of the present study is to examine the long-term effect of eccentric exercises compared with stretching exercises on patients with achillodynia.

patients with achillodynia for at least 3 months are randomly allocated to one of two exercise regimens. exercise is performed daily for a 3-month period. symptom severity is evaluated by tendon tenderness, ultrasonography, a questionnaire on pain and other symptoms, and a global assessment of improvement. follow-up is performed at time points 3, 6, 9, 12 weeks and 1 year.

Eligibility criteria:
inclusion criteria: 1. pain in the achilles tendon area with one of the two following findings. a) distinct tenderness of achilles tendon with no pain in the neighboring structures. b) ultrasonographic changes defined as local thickening of the symptomatic tendon or a globally more than 2mm thicker tendon on the sick side. 2. diffuse pain in the posterior region of the ankle with local tenderness of the achilles tendon and ultrasonographic changes (as described above). exclusion criteria: 1. treatment of achillodynia with stretching or eccentric training for more than 2 weeks within the last 2 years. 2. other injuries in the lower extremity or the knee, which by the examining doctor was evaluated to influence the evaluation of symptoms or the ability to perform the training program. 3. acute symptoms with ultrasonographic changes consistent with a partial rupture of the tendon. 4. age less than 18 years or over 70 years. 5. previous operation on the tendon or steroid injections.
evaluation of postoperative cognitive function, anxiety, depression and quality of life in patients with unruptured intracranial aneurysms

Conditions: Intracranial Aneurysm

Summary: this prospective single-center cohort study aims to identify the incidence of cognitive dysfunction after unruptured aneurysm operation and explore the influencing factors. the primary end point is the cognitive dysfunction at 6 months after operation.the features of cognitive function, mental status, neurological function recovery, and quality of life of patients with unruptured intracranial aneurysms at different time points would be analyzed.

this main topics is to identify and screen the patients with unruptured aneurysm who likely to suffer from cognitive dysfunction. all examinations were administered by a trained neuropsychologist.the assessment of cognitive function and mental state would be performed before operation and 6 months after operation, with the use of montreal cognitive assessment scale (moca) for the cognitive function, the hamilton anxiety scale (hama) and the hamilton depression scale (hdma) tests for the mental state. the cognitive dysfunction at 6 months after operation would be the primary end point, and the underlying factors responsible for the declined cognitive function would be analyze. the assessment of neurological function and quality of life would be performed before operation,3 months after operation and 6 months after operation, with the use of the modified rankin scale(mrs) and the functional activities questionnaire(faq) for the neurological function, the richards-campbell sleep questionnaire(rcsq) and the 36-item short from health survey(sf-36) tests for the quality of life.

Eligibility criteria:
inclusion criteria: 1. at least one imaging (cta / mri / dsa) study to confirm unruptured intracranial aneurysms for the patients who would undergo surgical treatment for the first time.; 2. patients who live independent with minimal care support, mrs score ≤3 points; 3. age \> 14 years old; 4. han ethnicity, right handed, can complete the test; 5. patient or family agrees to sign informed consent. exclusion criteria: 1. other cerebrovascular diseases，such as ischemic stroke, arteriovenous malformation, etc; 2. with an unexplained subarachnoid hemorrhage; 3. history of neurological disease surgery; 4. previous psychiatric and dementia history that cannot communicate with other people; 5. patients who refused to follow up.

Keywords: cognitive function quality of life anxiety depression neurological function
benefit of cheyne-stokes respiration remote monitoring in cpap-treated patients with obstructive sleep apnea to detect early events of heart failure.

Conditions: Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) syndrome affects 40-60% of patients presenting with cardiovascular diseases. cheyne-stokes respiration is a type of central apnea characterised by the presence of at least three consecutive episodes of apnea and/or hypopnea separated by a crescendo-decrescendo variation of the breathing amplitude with a cycle length ≥ 40 seconds and a central apnea/hypopnea index ≥ 5/h, for at least two hours of recording. the association between heart failure and cheynes-stokes respiration is known and a recent study showed that cheynes-stokes respiration was associated with more severe heart failure. moreover, a medical and medical/financial benefit of the early detection of cardiac decompensation has been reported. the purpose of this feasibility study is to investigate the benefit of cheyne-stokes respiration remote monitoring in cpap-treated patients with osa for the early detection of significant cardiac events (heart failure, rhythm disorder, diastolic dysfunction). to achieve this aim, a modified approach of cpap remote monitoring is proposed based on the performance of the latest generation of positive pressure devices from resmed, airsense™ 10 autoset™, which can detect and record the presence of cheynes-stokes respiration. for a period of 12 months, in addition to the usual daily remote monitoring (cpap adherence, pressure settings, level of air leakages), the healthcare provider will systematically monitor the csr data whenever the ahi increases significantly. physicians will be alerted when a csr occurs and they will see the patients within a short time for pulmology and cardiology consultations in order to screen the onset of significant cardiac event. after the 12-month period of modified remote monitoring, the telemedicine returns to the usual procedure. patients who had at least one csr occurrence during the first 12-month period will be followed up to 24 months to assess their medical condition.


Eligibility criteria:
inclusion criteria: * patient with severe osa treated with cpap (device airsense™10 autoset™ by resmed). * patient followed up by one of the lung specialist of the polyclinique saint-laurent and tele-monitored by the healthcare provider vitalaire. exclusion criteria: * enrolled in an interventionnal clinical trial.

Keywords: obstructive sleep apnea (oas) cheyne-stokes respiration (csr) continuous positive airway pressure (cpap) telemedicine heart failure
the effect of a pulmonary rehabilitation on lung function and exercise capacity in patients with burn

Conditions: Inhalation Injury; Pulmonary Disease

Summary: inhalation burn injury and lung complications caused by large surface burns occurring during a fire remains a serious problem. pulmonary rehabilitation has been used successfully to improve pulmonary function(pf) in patients with chronic obstructive pulmonary disease. but there were no studies that pulmonary rehabilitation induce improvements in pf in patient with large surface burn and inhalation injury. the investigators will performe pulmonary function and respiratory muscles strength evaluation in 40 patients with thermal injury in order to evaluate the effects of pulmonary rehabilitation in patients with thermally injury.

the investigators will performe pulmonary function and respiratory muscles strength evaluation in 40 patients with thermal injury in order to evaluate the effects of pulmonary rehabilitation in patients with thermally injury. the investigators will study 40 patients who had burn injury. burned patients will be randomized into two groups. the experimental group(eg) will participate in a 12-week pulmonary rehabilitation program daily for 60 minutes. the control group(cg) will participate in a 12-week conventional exercise program daily for 60 minutes. spirometer will be done to evaluate pulmonary function. pulmonary function tests include forced vital capacity(fvc), 1 second forced expiratory volume(fev1), forced expiratory flow rate between 25 and 75% of the fvc(fef 25-75) fev1/fvc ratio expressed as a percentage(fev1/fvc %) and peak expiratory flow(pef). maximum voluntary ventilation(mvv) and respiratory muscles strength(mep\[maximal expiratory pressure\], mip\[maximal inspiratory pressure\]) will be measured by mouth pressure-meter in sitting position. pulmonary function tests will be performed for all groups at baseline and after 12 weeks programs. a 6-minute walk test and health-related quality of life will be also evaluated.

Eligibility criteria:
inclusion criteria: * inhalation injury * the burn surface area of chest and neck are more than 50% of the anterior or posterior trunk areas. exclusion criteria: * vocal cord palsy * who were intubated * had a tracheostomy * anoxic brain injury * psychologicical disorders * quadriplegia * severe cognitive disorders * who took medications that affect pulmonary function.

Keywords: burn pulmonary function test pulmonary rehabilitation
identification of biomarkers of response after bariatric surgery in morbidly obese patients

Conditions: Morbid Obesity

Summary: the prevalence of obesity in spain is about 21.6%. the discouraging results provided by dietary treatment, together with the lack of funding for pharmacological treatment, have led to the progressive use of bariatric surgery (cb). besides weight loss, cb associates a beneficial effect on metabolic comorbidities. however, 25-30% of operated patients present a weight response considered inappropriate, they do not resolve their comorbidities and/or present a weight-regain shortly after surgery. therefore, predictive strategies are necessary to allow a correct selection of obese patients who are candidates for cb. the main hypothesis of the study is that various factors such as psychopathological profile, body composition and metabolic alterations related to morbid obesity can influence the response to bariatric surgery.

the investigators have designed a prospective study in which 200 consecutive patients from the outpatient clinic of the morbidly obesity unit of the vall d'hebron hospital will be included, meeting criteria for bariatric surgery (with bmi\> 40 kg / m2 or bmi\> 35 kg /m2 in the presence of comorbidities) and will undergo surgery in the investigator's center between september 2018 and september 2019. all patients will undergo (baseline, month, 6, 12 and 24 month): complete clinical history, analysis complete biochemistry, 2 blood samples will be extracted to study metabolomics, stool sample for microbiota study, bioimpedance for the study of body composition, determination of ages in the skin and lens, cognitive function assessment, retinal function assessment by microperimetry and they will be asked to complete several specific questionnaires for the evaluation of the psychopathological profile and the dietetic survey.

Eligibility criteria:
inclusion criteria: * patients fulfilling criteria for bariatric surgery (bs). * signed informed consent fir the bs and the study. * previous accomplishment of the preoperative protocol for the bs at our site. * undergo bs between september 2018 and december 2019 * able to read and understand the specific questionnaires. exclusion criteria: * any contraindication for the bariatric surgery. * impossibility to follow-up at our site (eg: patients from outside out community).

Keywords: morbid obesity bariatric surgery psychological profile