Kornimate/medical-research-clean huggingface dataset:
effect of cognitive behavioral therapy on depression and quality of life in patients with post covid-19

Conditions: Post-COVID-19 Syndrome

Summary: the goal of this clinical trial is to test the effect of rehacom on depression and quality of life in post covid -19 patients. the main question it aims to answer is: • is a cognitive rehabilitation therapy will improve depression and quality of life in patients with post covid-19? researchers will compare rehacom with exercise therapy to see if rehacom can improve depression and quality of life in patients with post covid-19 neuropsychological problems.

purpose of the study: * to investigate the effect of cognitive rehabilitation therapy on depression in post covid-19 patients. * to investigate the effect of cognitive rehabilitation therapy on quality of life in post covid-19 patients. significance of the study: •there is growing evidence that individuals with covid-19 disease can develop a range of neurological complications including cognitive and neuropsychiatric symptoms . cognitive rehabilitation essential in improving quality of life with introduction of new neuropsychological rehabilitation tools based on the latest developments in computer sciences. this study aims to investigate the rehacom as a cognitive rehabilitation program on depression and quality of life in patients suffer from post covid-19 neuropsychological problems.

Eligibility criteria:
inclusion criteria: * all patients will be selected according to following criteria: 1. patients from both genders (male and female). 2. the age of participants ranged from 30 to 45 years . 3. the patients had score more than 24 according to mini mental state examination (mmse). 4. patient muscle power not less than grade 3 . 5. patients are ambulant. 6. patients with confirmation of previous covid19 infection pcr test. 7. participants were required to live in egypt during the pre-covid and covid-19 pandemic. 8. patients meeting the guide line of world health organization (who) of long/post-covid 19 syndromes. 9. patients are "long-haulers" those who history of probable or confirmed sars-cov-2 infection; usually within three months from the onset of covid-19, and last more than two months exclusion criteria: * the patients will be excluded if they have any of the following: 1. patient previously diagnosed with depression and currently taking medication. 2. patient had prior cognitive impairment. 3. illiterate patients. 4. patient had experienced another major stressful event (e.g., divorce, bereavement) in the past year. 5. checking comorbidities (sum of hypertension, diabetes, arrhythmia, myocardial infarction, chronic obstructive pulmonary disease/asthma. 6. mild cognitive impairment, dementia, other neurodegenerative diseases, stroke, depression, 7. osteoarthritis , low back pain and prevalence of polypharmacy (5 or more drugs) at admission.

Keywords: rehacom post covid-19 cognitive rehabilitation depression quality of life
genotypic influences on network progression in parkinson's disease

Conditions: Parkinson's Disease

Summary: in this longitudinal study, the investigators will follow parkinson's disease (pd) patients with and without glucocerebrosidase (gba) mutations. the investigators hypothesize that the rate of increase in brain network activity over time (network progression rate) is faster in patients with gba gene mutations.

parkinson's disease (pd) patients with mutations in the glucocerebrosidase gene (gba) tend to have a more aggressive disease course. gba may therefore provide a target for disease modifying therapies in mutation carriers. using positron emission tomography (pet) and magnetic resonance imaging (mri) brain imaging to measure network progression rates in mutation carriers will allow for the assessment of the potential disease modifying effects of new anti-gba therapies. the investigators will also determine whether magnetic resonance imaging (mri) network methods, which are less invasive and more broadly available than positron emission tomography (pet), produce comparable network progression measurements in individual patients. these determinations will be critical for the design of clinical trials of new disease-modifying drugs.

Eligibility criteria:
inclusion criteria: * diagnosis of pd made according to united kingdom (uk) parkinson's disease society brain bank criteria * ability to provide written informed consent * age 40-75 * stable dose of antiparkinsonian medication for \>1 month prior to study entry exclusion criteria: * subjects with pathogenic mutations in lrrk2 related pd mutations (subjects with variants of uncertain significance (vus) are eligible * history of known causative factors such as encephalitis or neuroleptic treatment * patients with dementia (defined as mini-mental status exam score \<24 or a telephone interview for cognitive status score \<26) * atypical parkinsonian features including oculomotor abnormalities, incontinence, ataxia, sensory loss, or pyramidal signs * known structural brain lesions * patients with history of stroke, head injury, high intracranial pressure or severe headaches * psychiatric disorder, including a history of major depression in the past 36 months * pregnant or breastfeeding women (female subjects of child-bearing potential will be screened for pregnancy before imaging).

Keywords: gba genetic progression pd glucocerebrosidase
as an early indicator biomarker of prognosis and mortality in children with sepsis and septic shock: supar

Conditions: Septic Shock; Sepsis, Severe

Summary: the sepsis and septic shock remain major causes of child morbidity and mortality, despite the use of modern antibiotics and resuscitation therapies. recent interest has focused on biomarkers for early diagnosis, and evaluation the outcomes of sepsis; but there is a still lack of early diagnosis and timely intervention for sepsis in the emergency department (ed). the primary aim was to investigate the role of c-reactive protein(crp), procalcitonin(pct), soluble-urokinase plasminogen activator receptor(supar) and presepsin in the early stratification of patients with sepsis. the usefulness of pediatric sequential organ failure assessment (psofa) for predicting of the mortality and the rate of picu admission in children with septik shock were also investigated. this prospective pilot study was conducted at academic pediatric ed between september 2017-june 2018. all children who met sepsis criteria admitted to ed were involved to study. they kept following up after ed management and their blood samples were taken upon admission on day 0, 1, 2, 4 and 7. the definition made as sepsis, severe sepsis and septic shock. at the same period, 100 healthy children chosen as the control group. the patient characteristics, clinical features, diagnosis, co-morbidities, source of infection, laboratory results (crp, pct, lactate, supar and presepsin) and treatments were recorded. the psofa score was calculated during first hour of admission. length of stay in ed and hospital was noted. the main outcome measure was in 7 and 30-day mortality.


Eligibility criteria:
inclusion criteria: * \<18 years * admitted to emergency department with sepsis exclusion criteria: * \>18 years * diagnosed non-sepsis

Keywords: sepsis supar septic shock children mortality
copeptin as a diagnostic marker in the management of neurosurgical patients with disturbance of water homeostasis

Conditions: Pituitary Adenoma

Summary: water imbalance and consecutive electrolyte disturbances are common in the postoperative course of neurosurgical patients after pituitary surgery. diabetes insipidus (di) may complicate the postoperative course in as many as 30% of patients. early and accurate diagnosis of water and electrolyte disturbances postoperatively is important for an adequate fluid and drug administration. however, identifying the causes is challenging/ ambiguous in clinical practice. levels of antidiuretic hormone (adh) might contribute to a straightforward diagnosis, though, its measurement is cumbersome. adh is derived from a larger precursor peptide along with copeptin, which is a more stable peptide directly mirroring the production of adh. copeptin can be assayed readily in plasma. aim: to investigate whether copeptin can accurately diagnose postoperative disturbances of water homeostasis (i.e. diabetes insipidus and siadh) in a cohort of patients undergoing intracranial tumor surgery.


Eligibility criteria:
inclusion criteria: * all consecutive patients who undergo surgery for an intra- or suprasellar lesion, either by craniotomy or by transphenoidal resection.

Keywords: copeptin siadh diabetes insipidus transphenoidal pituitary adenoma resection pituitary adenoma tumors close to pituitary gland tumors close to hypothalamus
comparison of pre-hospital and in-hospital iv-tpa stroke treatment

Conditions: Ischemic Stroke

Summary: this is a comparison of clinical outcomes between a pre-hospital and an in-hospital thrombolysis patient registry.


Eligibility criteria:
inclusion criteria: * acute ischemic stroke diagnosis with thrombolytic treatment * admission via ems * known premorbid status of need of assistance * nihss before treatment available * time of onset (or last well seen) between 4:00am and 10:30pm exclusion criteria: * unknown time of onset * in-hospital thrombolysis despite decision against treatment because of contraindications in stemo

Keywords: stroke thrombolysis stemo
compliance to ophthalmic follow-up examinations and surgical outcome for proliferative diabetic retinopathy

Conditions: Proliferative Diabetic Retinopathy

Summary: the relationship between the surgical outcome of vitreous surgery for proliferative diabetic retinopathy and the compliance to ophthalmic follow-up examinations was evaluated.

the medical records of 94 patients that had undergone vitreous surgery for proliferative diabetic retinopathy (pdr) and were followed for at least 6 months were reviewed. the subjects were divided into three groups; the never-treated group consisting of patients who had no previous ophthalmic examination until the first visit when vitreous surgery was prescribed; the non-compliant group consisting of patients with a history of missing ophthalmic examination over a one year period, and the compliant group consisting of patients who had ophthalmic examinations at least once a year. the evaluations included age, gender, plasma level of glycosylated hemoglobin (hba1c) at the preoperative examination, presence of preoperative panretinal photocoagulation, preoperative best-corrected visual acuity (bcva), postoperative bcva at the final examination, status of the pdr, the numbers of vitreous surgeries, and presence of pre- and postoperative neovascular glaucoma.

Eligibility criteria:
inclusion criteria: * one hundred and twenty-eight eyes of 94 patients that had undergone vitreous surgery for proliferative diabetic retinopathy. * type 2 diabetes. exclusion criteria: * the patients were not followed more than 6 months.

Keywords: periodic examinations, compliance
intensive outpatient treatment for suicidal veterans

Conditions: Suicidality

Summary: this investigation is a feasibility study conducted in a va outpatient treatment setting. the study is designed to test the feasibility of implementing a novel way of working with suicidal patients, the collaborative assessment and management of suicidality (cams). the primary purpose of the proposed project is to determine if it is possible to train clinicians working in the mental health clinic at the denver va medical center (vamc) to utilize this therapeutic framework. this project is extremely timely in relation to expectations of future increased clinical demands among potentially high-risk operation enduring freedom/operation iraqi freedom (oef/oif) veterans who may become suicidal in the years to come.


Eligibility criteria:
inclusion criteria: 1. suicidality endorsed during the regular mental health intake interview or at the time of admission. 2. over the age of 18 years. 3. new or returning patients to the va mhc. 4. living within the larger denver metropolitan region during the duration of the treatment. 5. willing to travel to the echcs denver vamc at times other than scheduled therapy appointments to complete follow-up assessment measures. exclusion criteria: 1. psychosis that would interfere with an individual's ability to provide informed consent. 2. imminent suicidality with the need for immediate psychiatric hospitalization, as defined above in the background section, at the time of mh intake. 3. current involuntary status for psychiatric hospitalization. 4. inability to adequately respond to questions regarding the informed consent procedure. see special consent issues section below.

Keywords: suicide veterans assessment cams
development of the leeds food preference questionnaire in spanish

Conditions: Fasting; Fed

Summary: the leeds food preference questionnaire (lfpq) is a computer-based task used to measure reward responses and preferences for images of food. the present study aims to develop a spanish version of the lfpq (es-lfpq) by examining its validity and repeatability under fasted and fed states.

the leeds food preference questionnaire (lfpq) is a computer-based task for measuring reward responses (liking/wanting) and preferences for images of food. there are no cultural adaptation studies for the spanish population to date in order to address its validity and repeatability in a test-retest design. the present study aim to develop a spanish version of the lfpq (es-lfpq), examine its outcomes under fasted and fed states; and test its reproducibility after one week. an online survey containing foods that were either low-fat sweet, high-fat sweet, low-fat savoury or high-fat savoury was first conducted among a sample of 96 spanish adults (60.4 % women) to develop and validate a culturally appropriate food image database. 50 participants (25 men and 25 women) will participate in two identical trials where they will completed the es-lfpq under fasted and fed states (immediately after a standardised meal), at least one week apart.

Eligibility criteria:
inclusion criteria: * being able to understand instructions, programs and questionnaires. * being able to recognize the foods presented in at least 4 of the 5 photographs available for each category that make up the es-lfpq. * living in spain for at least 2 years exclusion criteria: * being intolerant, allergic and/or having an aversion to the foods contained in the standardized meal. * never eat the foods presented in at least 4 of the 5 photographs available for each category that make up the es-lfpq
epidemiological study of intestinal colonization with staphylococcus aureus

Conditions: Staphylococcus Aureus

Summary: nasal colonization with s. aureus is a risk factor for infection with this bacterium. a methodologically well conducted study of s. aureus bacteremia showed that 80% of s. aureus bacteremia with are due to the strain isolated in the nasal level. however, as part of a study coordinated by the chu of saint-etienne, less than 50% of infections in prosthetic orthopedic devices have been linked to nasal carriage . outside of exogenous infections, intestinal colonization with s. aureus could be an alternative source of endogenous infections with the waning of orthopedic surgery. in the general population, considering that about one third of the subjects were colonized with s. aureus nasal level and 1 in 5 in the intestine however the proportion of exclusive intestinal porting is not well known . this study will analyze, among icu patients, porting s. aureus nasal and rectal level. it will better clarify the relationship between nasal and rectal ports and the risk of developing an infection.

the adult patients hospitalized in intensive care at the university hospital of saint-etienne have a multiresistant bacteria porting screening at the nose and rectum at admission and then once a week. these samples will be carried unchanged way for the study but will also be a research s aureus

Eligibility criteria:
inclusion criteria: * patients hospitalized in intensive care and benefiting from a screening multiresistant bacteria in nasal and rectal level under routine care exclusion criteria: * refusal of the patient's family

Keywords: intensive care s aureus
nsaid use in postpartum hypertensive women

Conditions: Hypertension

Summary: women who have the diagnosis of hypertension (pre-pregnancy and pregnancy induced) and deliver an infant via vaginal delivery will be placed into two groups in the postpartum period. one group will receive ibuprofen for pain control and the other group will be given tylenol. blood pressures during the postpartum period will then be collected and compared in order to see if nsaids use increases blood pressure.

the patients who have a vaginal delivery and have the diagnosis of hypertension in pregnancy will be randomized to either ibuprofen use or acetaminophen use during the postpartum period. standard blood pressure monitoring in the postpartum period will be followed to help determine if there is a significant rise in the women who use nsaids in the postpartum period versus those that use acetaminophen. groups will be divided into women with chronic hypertension, women with chronic hypertension with superimposed preeclampsia, women with preeclampsia without severe features, women with preeclampsia with severe features, women with gestational hypertension without severe range blood pressures, and women with gestational hypertension with severe range blood pressures. recruitment will last 36 months. patients will be monitored during their postpartum stay (typical 2 days) with blood pressure measurements. an additional 12 months will be needed for data analysis and publication.

Eligibility criteria:
inclusion criteria: * vaginal delivery * diagnosis of chronic hypertension, chronic hypertension with superimposed preeclampsia * preeclampsia without severe features * preeclampsia with severe features gestational hypertension without severe range blood pressures * gestational hypertension with severe range blood pressures * singleton pregnancies exclusion criteria: * cesarean delivery * no diagnosis of hypertensive disorder * chronic or acute renal disease * allergy to ibuprofen or acetaminophen * lupus * multiple order pregnancies (twins, triplets) * narcotic addiction/ in treatment for substance abuse/ current prescription drug user/ current use of illegal drugs
landmark guided intercostobrachial nerve block versus serratus plane block after supraclavicular plexus block for anesthesia in creation of arteriovenous fistula in the medial side of the arm

Conditions: Intercostobrachial Nerve Block; Serratus Plane Block; Supraclavicular Plexus Block; Arteriovenous Fistula

Summary: this study aims to compare the role of ultrasound-guided and landmark-guided intercostobrachial nerve block and serratus plane block after supraclavicular plexus block for anesthesia in the creation of an arteriovenous fistula in the medial side of the arm.

brachial plexus block (bpb) is usually utilized for proximal arm arteriovenous access creation. it has been suggested that supraclavicular brachial plexus block (scpb) could be an alternative and provide comparable effective anesthesia and postoperative analgesia for arm surgery, with a reduced incidence of adverse events, including hemidiaphragmatic paresis. by performing scpb, the inner part of the arm is not completely anesthetized because this part of the arm is innervated by the lateral cutaneous branch of the second intercostal nerve (intercostobrachial nerve (icbn)) and the medial branch of the brachial cutaneous nerve. serratus plane block (spb) was first defined in 2013 by blanco et al. this block provides anesthesia and analgesia in the hemi-thorax, where it is applied to block the thoracic intercostal nerves, in addition to the axillary region and shoulder posteriorly.

Eligibility criteria:
inclusion criteria: * age from 18 to 65 years. * both sexes. * american society of anesthesiology (asa) physical status i-ii. * scheduled for creation of arteriovenous fistula in the medial side of the arm. exclusion criteria: * allergy to local anesthetics. * drug addiction. * coagulation abnormalities. * body mass index (bmi)≥35 kg/m2. * upper extremity neuropathy. * vasculitis. * unstable hemodynamics. * history of seizures or mental illness. * severe heart, kidney, and liver diseases. * pregnancy.
clinical scenarios for long-term monitoring of epileptic seizures with a wearable biopotential technology

Conditions: Epilepsy

Summary: clinically validate a biopotential and motion recording wearable device (byteflies sensor dot) for detection of epileptic seizures in the epilepsy monitoring unit (emu) and at home.

subjects with refractory epilepsy who are admitted to the epilepsy monitoring unit (emu) for clinically-indicated long-term video-eeg assessment will be simultaneously monitored with sensor dots to record electroencephalographic (eeg), electrocardiographic (ecg), electromyographic (emg), and motion signals. a subset of subjects will continue using sensor dot devices at home (home phase) after completing the emu phase. the data recorded by sensor dots will be used to: 1) annotate epileptic seizures, which will be compared to the annotations made as part of routine emu monitoring and seizure diaries kept at home, and 2) to develop seizure detection algorithms. the data collected as part of this study will not be used to influence clinical decision making.

Eligibility criteria:
inclusion criteria: * subjects (4+ years old) with refractory epilepsy who are admitted to the hospital for clinically-indicated long-term video-eeg assessment or presurgical evaluation, and a high likelihood of experiencing seizures during the emu phase * for subjects continuing into the home phase: successful recording of their habitual seizures with sensor dot during the emu phase * for subjects continuing into the home phase: the ability to keep an e-diary exclusion criteria: * known allergies to any of the biopotential electrodes or adhesives used as part of the study protocol * having an implanted device, such as (but not limited to) a pacemaker, cardioverter defibrillator (icd), and/or neural stimulation device because sensor dot contains magnets that could interfere with the operation of these devices * women who are pregnant

Keywords: seizure detection wearable epilepsy seizure sensor dot