Kornimate/medical-research-clean huggingface dataset:
catholic medical center percutaneous coronary intervention registry (coact)

Conditions: Drug Eluting Stent; Coronary Artery Disease; Polymorphism; Cholesterol; Biomarker

Summary: coact registry is a multicenter registry of consecutive patients undergoing coronary stent implantation at 8 centers in the catholic university of korea to evaluate the real world management of patients with coronary artery disease and to assess their in-hospital, medium and long-term outcomes.


Eligibility criteria:
inclusion criteria: * all consecutive patients who underwent percutaneous coronary intervention * written informed consent for the dna and serum databank exclusion criteria: * patients who did not agreed to participate

Keywords: drug eluting stent coronary artery disease korean registry
child pneumococcal serotype epidemiology in greece

Conditions: Pneumococcal Disease

Summary: streptococcus pneumoniae is a major cause of pneumonia, sepsis, bacteremia, and pneumococcal meningitis among infants and children worldwide. the 7-valent conjugate pneumococcal vaccine (prevenar) has been introduced in the greek market in 2004. additionally, as of 2006 prevenar has been included in the greek national immunization program. the effect of the mass vaccination on the incidence of pneumococcal serotypes involved in the occurring invasive pneumococcal disease, is an important factor to consider for the introduction of the 13-valent pneumococcal conjugate vaccine.

open label, one group purposive sampling of hospitalized children ≤14 years of age with confirmed ipd

Eligibility criteria:
inclusion criteria: * children aged 14 years old or less. * hospitalized in a participating healthcare facility with an ipd. * ipd will be confirmed by isolation of s. pneumoniae from a sterile body site. exclusion criteria: * children \> 14 years of age * unconfirmed ipd

Keywords: invasive pneumococcal disease (ipd) pneumococcal serotypes
health economic research on oral nutritional supplements for hospitalized patients with nutritional risk

Conditions: Malnutrition; Nutritional Risk

Summary: the goal of this observational study is to evaluate the treatment effect and health economic impact of oral nutritional supplements(ons) in hospitalized patients with nutritional risk. the main questions it aims to answer are: * to evaluate the effect of ons on clinical outcomes in hospitalized patients with high nutritional risk * to evaluate the health economic impact of ons in hospitalized patients with high nutritional risk data was collected from patients admitted to peking union medical college hospital between january 1, 2018 and december 31, 2020. the inclusion criteria were as follows: (1) age≥18 years old; (2)length of hospital stay≥3days; (3) only ons was used as enteral nutrition or no enteral nutrition was received. exclusion criteria were: (1) age\<18; (2) length of hospital stay\<3 days; (3) the patients who received enteral nutrition other than ons (such as tube feeding); (4) emergency admissions; (5) the patients who transferred from other hospitals; (6) pregnancy or lactation we collected the following data through the hospital big data query and analysis system: 1. basic information: gender, age, height, weight, medical insurance, etc. 2. clinical information: admission paths, admission time, admission departments, discharge time, discharge unit, length of stay, mode of payment； 3. disease information: admission diagnosis, disease coding at admission, the first discharge diagnosis, the coding of first discharge diagnosis, the second discharge diagnosis, the third discharge diagnosis, outcome (recovery, improvement, not cured, death, transfer to another hospital) 4. operation information: surgical name, surgery code, 5. oral nutritional supplement: drug names, unit price 6. laboratory examination: hemoglobin, albumin, prealbumin 7. hospitalization costs: total cost, self-pay cost, other cost, the type of medical insurance； researchers will compare ons group to see the clinical outcomes and health economic impact.


Eligibility criteria:
inclusion criteria: 1. age≥18 years old; 2. length of hospital stay ≥3days; 3. only ons was used as enteral nutrition or no enteral nutrition was received. exclusion criteria: 1. age\<18; 2. length of hospital stay\<3 days; 3. the patients who received enteral nutrition other than ons (such as tube feeding); (4) emergency admissions; (5) the patients who transferred from other hospitals; (6) pregnancy or lactation
lung function and inflammatory markers in cement dust exposed workers: a cross-shifts study

Conditions: Airway Obstruction

Summary: the aim of the study is to examine possible changes in lung function, nitric oxide levels and systemic inflammatory markers in cement dust exposed workers, during one shift (6-8 hours).

objective: cement dust is suspected to be one of the main factors causing increased mortality among workers not only in the cement production industry, but also in the construction industry worldwide. our aim is to examine possible changes in lung function, nitric oxide levels and systemic inflammatory markers in cement dust exposed workers, during one shift (6-8 hours). methods: all employees from norwegian cement plants, are invited to participate. the workers will perform spirometry, single-breath determination of carbon monoxide uptake, blood samples before and after a working shift of 6-8 hours, and again after 24 hours. information on respiratory symptoms, allergy and former respiratory disease as well as exposure information will be given on a self-reported questionnaire. changes in lung function indices, nitric oxide levels and serum inflammatory markers will be calculated. nitric oxide will only be measured in non-smokers. we will compare cement dust exposed workers with low-level or non-exposed workers (controls).

Eligibility criteria:
inclusion criteria: * employees from a norwegian cement production plant exclusion criteria: * exhaled nitric oxide measurements: smokers * substantial previous work in quarry or as a miner

Keywords: cement dust exposure cross-shift study lung function indices exhaled nitric oxide serum inflammatory markers
association between the use of pulmonary artery catheter and clinical outcomes after liver transplantation

Conditions: End Stage Liver DIsease; Liver Transplant; Complications; Liver Cirrhosis; Liver Diseases

Summary: the investigators attempted to evaluate whether the use of pac is associated with better clinical outcomes after liver transplantation compared with the case without pac.

pulmonary artery catheter (pac) has been used for advanced hemodynamic monitoring during liver transplantation. however, recent advances in less invasive monitoring could provide continuous cardiac output monitoring by arterial waveform analysis. using this technology, stroke volume variation (svv) is monitored as a preload index. calculated systemic vascular resistance (svr) can be monitored if central venous pressure (cvp) is provided. therefore, this less invasive form of hemodynamic monitoring may replace the pac. the investigators attempted to evaluate whether the use of pac is associated with better clinical outcomes after liver transplantation compared with the case without pac.

Eligibility criteria:
inclusion criteria: * adult patients who underwent living or deceased donor liver transplantation at our tertiary care university hospital between 2006 and 2022 exclusion criteria: * patients with baseline renal dysfunction * missing baseline or outcome variables * retransplantation * patients who received intraoperative transesophageal echocardiography (tee) monitoring
indomethacin prophylaxis for heterotopic ossification after surgical treatment of elbow trauma

Conditions: Elbow Trauma Requiring Operative Management

Summary: patients who present to our institution with a traumatic injury to their elbow who need operative management will be randomized to one of two groups; a treatment arm and a control arm. the treatment arm will receive a three-week postoperative course of indomethacin while the control group will not. we will follow both groups to assess whether or not indomethacin prophylaxis affects the rate of heterotopic ossification.


Eligibility criteria:
inclusion criteria: * terrible triad * radial head fracture surgical treatment * monteggia and trans-olecranon fracture dislocations * distal biceps tendon injuries * distal humerus fractures * coronoid fractures * capitellar-trochlear fractures * olecranon fractures exclusion criteria: * associated traumatic brain injury * burn injuries associated with elbow trauma * history of gastric ulcers * documented allergies to any non-steroidal anti-inflammatory drugs (nsaids) * severe asthma * previous operative fixation to affected elbow * participation in other research study * inability to speak / understand english

Keywords: elbow trauma,heterotopic ossification,indomethacin, prophylaxis
comparative effects of instrumental assisted soft tissue mobilization and sustained stretching among hockey players

Conditions: Sports Physical Therapy

Summary: effect of instrumental assisted soft tissue mobilization over sustained stretching in hockey players on improving quadratus lumborum flexibility.

to find the effect of instrumental assisted soft tissue mobilization over sustained stretching in hockey players on improving quadratus lumborum flexibility.

Eligibility criteria:
inclusion criteria: age group of 16-26 years. male and female deficit of thoracolumbar range of motion with ql tightness participates with moderate pain as per the odi (20%-40%) exclusion criteria: not fit in the age group who have muscles injury from last 6 months who have odi score less than 20% who do not involve ql tightness

Keywords: quadratus lumborum muscle low back pain iastm instrument-assisted soft tissue mobilization range of motion sustained stretching
quality of recovery after hip fracture surgery: us-guided peng block versus ficb

Conditions: Enhanced Recovery After Surgery

Summary: patients were randomly divided into two groups to receive either ultrasound-guided pericapsular nerve group block (peng group) or fascia iliaca compartment block (ficb group), using 20 ml of 0.2% ropivacaine

participants were randomly divided into two groups : group peng and group ficb, to receive either ultrasound-guided pericapsular nerve group block or fascia iliaca compartment block, using 50 ml of 0.2% ropivacaine. for the ficb, a linear ultrasound probe was placed in the transverse plane and start scanning at the level of the inguinal crease to identify the femoral artery medially and the femoral nerve lateral to the femoral artery. the iliopsoas muscle should be seen overlying fascia iliaca. the block should be performed proximal to the arterial bifurcation. a 50 mm needle was introduced using an in-plane approach to penetrate the fascia iliaca. the hydro dissection separate the fascia iliaca from the iliac muscle, and a total volume of 20 ml of 0.2% ropivacaine was injected in this created space. the peng bloc is performed with a low frequency curvilinear ultrasound probe, which was initially placed in a transverse plane over the antero inferior iliac spine and the aligned with the pubic ramus by rotating the probe counterclockwise approximately 45 degrees. in this view, it is possible to observe the iliopubic eminence, the iliopsoas muscle tendon, the femoral artery and the pectineus muscle. a 100 mm needle was inserted from lateral to medial in an in-plane approach to place the tip in the musculofascial plane between the psoas tendon anteriorly and the pubic ramus posteriorly. negative aspiration should be observed before injection of local anaesthetic and a total volume of 20 ml of 0.2% ropivacaine was injected. spinal anesthesia was performed after 20 minutes. qor-15 score was assessed before the intervention and 24 hours postoperatively.

Eligibility criteria:
inclusion criteria: * patients aged above 65 years * patients with an american society of anesthesiologists physical status i to iii * patients undergoing hip fracture surgical repair exclusion criteria: * patients with an american society of anesthesiologists physical status iv or more * inability or refusal to sign informed consent * contraindications for regional nerve block or spinal anesthesia * impaired cognition or dementia

Keywords: hip fracture surgery peng block fascia iliaca compartment block quality of recovery
medication adherence in patients with inflammatory bowel disease (ibd)

Conditions: Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis

Summary: the purpose of this is to formally assess health literacy and medication adherence in participants with inflammatory bowel disease (ibd). the study also aims to improve medication adherence, health-related quality of life, and disease activity through a 24-week intervention.

the purpose of this study is to formally assess health literacy and medication adherence in participants with inflammatory bowel disease (ibd). the study also aims to improve medication adherence, health-related quality of life, and disease activity through a 24-week intervention that will include telephone reminders, educational materials, visits to the physician, and financial counseling.

Eligibility criteria:
inclusion criteria: * new or existing diagnosis of inflammatory bowel disease (ibd) proven via endoscopy, pathology, and radiology findings * maintained or started on a medication for inflammatory bowel disease at the time of enrollment * ability to speak english * good hearing * phone availability exclusion criteria: * pregnancy or plans to be pregnant * inability to make own health care decisions * inability to participate in the study phone calls * uncontrolled psychiatric illness * enrollment in another clinical trial outside of the standard clinic ibd registry

Keywords: digestive disease and disorders inflammation
prospective study determining the pain response, functional interference and quality of life in patients undergoing radiofrequency ablation assisted vertebroplasty/ cementoplasty

Conditions: Neoplasms; Cementoplasty; Quality of Life

Summary: bone metastases are a cause of significant morbidity in cancer patients. in patients who die from breast, prostate, and lung cancer, autopsy studies have shown that up to 85% have evidence of bone metastases at the time of death (1). these metastases frequently give rise to complications that reduce patients' quality of life. these include: pain, fractures, and decreased mobility, ultimately reducing performance status. radiofrequency ablation therapy with cementoplasty/vertebroplasty for painful bone metastases has been shown to be feasible, efficacious, and safe. however, patient reported outcomes have yet to be determined.


Eligibility criteria:
inclusion criteria: 1. histologically or cytologically proven malignancy. 2. patients aged 18 and above. 3. advanced cancer with bone metastasis(es) to the spine and/or pelvis 4. symptomatic with axial pain from spinal lesions and at risk for pathological fracture, or, pathological fracture without spinal cord compromise 5. karnofsky performance status (kps) greater than or equal to 40 at the time of baseline evaluation. 6. is planned to receive rfa and/or cementoplasty with treatment to all sites being followed for study. 7. is able to provide worst pain score at bony metastatic site(s). 8. patient is able and willing to fill out daily diary. 9. patients must be able to provide informed consent prior to being enrolled to the study. exclusion criteria: 1. progressive neurological compromise 2. pathological fracture of vertebrae with significant cortical involvement or spinal canal compromise 3. central nervous system metastases 4. inability to record pain score, complete diary and communicate this to study personnel.

Keywords: radiofrequency ablation bone metastases
positron emission tomography in rheumatoid arthritis with adalimumab (petra)

Conditions: Rheumatoid Arthritis

Summary: biologics are routinely used for the treatment of rheumatoid arthritis (ra). adalimumab is a human monoclonal antibody that inhibit the tumor necrosis factor alpha (tnf-alpha). identification of ra patients who respond to biologics is a challenging goal to avoid unnecessarily, costly and potentially harmful treatment. the aim of the study is to address if 18 f fdg is a valuable biomarker for the assessment of the clinical response in ra with tnf-alpha blocking agent. eight patients fulfilling the acr (american college of rheumatology) criteria will by enrolled. patient will receive adalimumab according to the current guidelines i.e. 40mg /14 days sub cutaneously. the decision will stand on a high activity of the disease defined by the das 28 (disease activity score) above 5.1. positron emission tomography will be performed before, 2 and 12 weeks after the begin of the treatment. the response to adalimumab will by assessed by the suv (standard unit value) measured on the inflammatory joints of hands, wrist, ankle, feet and knees and compared to measurement of clinical (total swollen and tender joints count) echographic (synovium thickness and power doppler) and chemical biomarkers (erythrocyte sedimentation rate, c reactive protein).


Eligibility criteria:
inclusion criteria: - patients with active rheumatoid arthritis pr définie selon les critères acr (1987) (annexe 7) \[18\], activité importante de la maladie (das 28 \> 5,1) (annexe 5) \[7\], indication d'un traitement par adalimumab (en accord avec l'a.m.m.), homme ou femme dont l'âge est supérieur ou égal à 18 ans, acceptant de participer à l'étude et ayant donné son consentement éclairé, affiliés ou bénéficiaire d'un régime de sécurité sociale.

Keywords: rheumatoid arthritis positron emission tomodensitometry tumor necrosis factor alpha inhibitor
safety and feasibility of prima-temp thermometer patch

Conditions: Erythema; Edema; Papules White; Eruption

Summary: the purpose of this study is to test the safety and feasibility of the prima-temp thermometer patch in determining baseline temperatures of research subjects in a hospital intensive care unit (icu). primary objective: assess safety of the prima-temp temperature patch with nursing staff skin site assessments. secondary objective: establish individual subject baseline temperature using intermittent temperature measurements (every 5 minutes) with the prima-temp thermometer patch and wireless transmission of the data to a receiver box and hipaa compliant, centrally located personal computer (pc) and compare research subject's baseline temperature with temperatures taken in the icu in the normal course of care.

the manifestation of fever and its characteristics is essential to the care of intensive care unit patients. as a marker for infection or other disease process, the presence of a fever and its temperature peak must be reliably obtained in icu patients and must be monitored closely to optimize effective therapy. inherent variability of different temperature measurement methods can lead to a difficulty in determining the optimal timing of medical interventions. ideally, nurses and medical staff in acute care hospital facilities could have a temperature monitoring system that aids recognition of fever and systemic infection that is not labor intensive and provides consistent and reliable temperatures. automatic transmission to a data recorder lessens the chances of manual entry error into the medical record. frequent measurements allow establishment of a patient's individual baseline temperature to provide individualized guidelines for medical interventions with an increase of 2°f above baseline as documentation of a fever. finally, the frequent temperature monitoring should be minimally invasive and comfortable to the patient.

Eligibility criteria:
inclusion criteria 1. men and women of any race. 2. men of age \> 18 years 3. women with no childbearing potential (age \> 50, age ≥ 18 s/p hysterectomy) 4. arm circumference \>23 cm and \< 38 cm exclusion criteria 1. patient with known or documented adhesive, tegaderm allergies. 2. abnormal axillary integument such as rashes, burns, laceration. 3. hidradenitis suppurativa and/or dermatologic diseases that might interfere with the evaluation of the test site reactions. 4. non-english speakers 5. pregnant women 6. patient requiring hypothermic therapy, with the exception of non-steroidal anti-inflammatory treatment (acetaminophen, ibuprofen, aspirin, etc).
intense airway eosinophilia in asthma

Conditions: Asthma; Eosinophilic Asthma

Summary: in asthma, the type and importance of the inflammatory response in the airways has allows identification of different phenotypes. of these, one of the most common is eosinophilic asthma, based on induced sputum differential cell count. patients with severe asthma and an eosinophilic asthma phenotype have different pathophysiological characteristics than those seen in patients with with mild asthma. however, few studies have compared patients with eosinophilic phenotype according to the severity of asthma. in addition, the stability of the phenotype based on the sputum results has been criticized. this study aims to describe the characteristics of patients with eosinophilic asthma phenotype according to the severity of asthma and determine the stability of the phenotype.

characteristics of asthmatic subjects with sputum eosinophilia will be compared according to asthma severity.

Eligibility criteria:
inclusion criteria: * aged 18 years and over * with a proven diagnosis of asthma as defined by one of the above criteria of current guidelines (36): 1. forced expiratory volume in one second (fev1) increase by at least 12% (and ≥200 ml) after administration of a bronchodilator 2. current asthma symptoms and a methacholine provocative concentration inducing a 20% fall in fev1 (pc20) \<16 mg/ml 3. a respirologist's current diagnosis of asthma found in the patient's medical report 3. non-smokers or smokers/ex-smokers defined as someone with a smoking history \<10 pack-years 4. with sputum differential cell count result 5. considered to receive optimal treatment for their disease (as per current guidelines except for patients included in exploratory objective 1. 6. stable asthma and asthma medication for at least 4 weeks before data analysis 7. written informed consent obtained for inclusion in the database exclusion criteria: 1. any respiratory disease apart from asthma 2. current or ex-smokers should not have a smoking history ≥10 pack-year before data analysis. patients who administer nicotine in other forms (patches, chew tobacco, e-cigarette, etc.) will be excluded 3. unstable asthma medication \<4 weeks before data analysis 4. asthma exacerbation (see definition below) \<4 weeks before data analysis 5. respiratory tract infection \<4 weeks before data analysis

Keywords: eosinophil phenotype cluster asthma severity