Kornimate/medical-research-clean huggingface dataset:
effect of exercise on endothelial function and vascular compliance in chronic kidney disease

Conditions: Kidney Failure, Chronic

Summary: the study hypothesis is that 6 weeks of repetitive handgrip exercise will improve endothelial function and venous compliance in pre-dialysis patients with an estimated glomerular filtration rate of less than or equal to 20 ml/min. if proven correct then arm exercise might be useful to improve the success rate for a surgically created arteriovenous fistula in the forearm to become usable as a vascular access for hemodialysis.

an arteriovenous fistula (avf) is the optimal vascular access for chronic hemodialysis. however, avfs frequently fail to mature. better strategies are needed to promote avf maturation. successful avf maturation involves arterial and venous dilation. arterial dilation depends on endothelial release of nitric oxide which can be measured by brachial artery flow-mediated dilation (fmd) and has been reported to predict successful avf maturation. venous dilation depends on venous compliance which can be measured by venous plethysmography and is also predictive of successful avf maturation. endothelial function is impaired in patients with chronic kidney disease (ckd). aerobic exercise has been reported to improve endothelial function and venous compliance but it has not been studied in the pre-dialysis patient. to address this question we will determine whether 6 weeks of repetitive handgrip exercise with upper arm venous compression can improve brachial artery endothelial function or venous compliance in pre-dialysis patients with an estimated glomerular filtration rate of less than or equal to 20 ml/min.

Eligibility criteria:
inclusion criteria: * age exceeding the age of majority (18 years of age). * chronic renal failure with a calculated gfr (mdrd equation) less than or equal to 20 ml/min * eligible for creation of an arteriovenous fistula for the purpose of hemodialysis. * the subject is expected to stay within driving distance of study site for at least 4 months. * the subject's physician(s) will allow the patient to participate. * ability to give informed consent. exclusion criteria: * unstable angina. * uncontrolled hypertension (resting blood pressure \>170 systolic or \>100 diastolic). * musculoskeletal or neurologic problem that prevents arm exercise. * currently functioning arteriovenous access in the same arm as the planned new fistula. * subjects who are eligible to participate in the ongoing dac fistula trial. * planned new access surgery in less than 6 weeks * anticipated non-compliance with medical care based on physician judgment. * patient refusal.

Keywords: endothelium vasodilatation vein compliance arteriovenous shunt, surgical
a study to evaluate the safety, tolerability, drug levels, and drug effects of bms-986326 in participants with atopic dermatitis

Conditions: Dermatitis, Atopic

Summary: the purpose of this study is to assess the safety, tolerability, drug levels, drug effects, and impact on disease severity of bms-986326 in participants with moderate-to-severe atopic dermatitis (ad).


Eligibility criteria:
inclusion criteria: * must have diagnosis of atopic dermatitis (ad) at least 12 months prior to screening * documented history of inadequate response to treatment with topical medication for at least 4 weeks, unless topical treatments are otherwise medically inadvisable, or has required systemic therapy for control of disease * all the following must be present to confirm moderate-to-severe ad * eczema area and severity index score ≥ 12 (at screening and day 1) * body surface area ≥ 10% (at screening and day 1) * validated investigator global assessment for atopic dermatitis ≥ 3 (at screening and day 1) * peak pruritus numerical rating scale ≥ 4 (at screening) exclusion criteria: * evidence of an active and/or concurrent inflammatory skin condition that would interfere with the investigator or subject-driven evaluations of ad * any major surgery within the last 30 days before the first dose of study intervention, or any surgery planned during the course of the study * any other sound medical, psychiatric, and/or social reason as determined by the investigator other protocol-defined inclusion/exclusion criteria apply

Keywords: skin disease dermatitis eczema
testing the effect of exercise intervention using a smart design.

Conditions: Fat Burn

Summary: exercise is the most effective way on reducing visceral adipose tissue (vat), which is strongly linked with obesity to hypertension, cardiovascular disease, and insulin resistance. however, the current exercise dosage for reducing vat cannot be accurately quantified. the aims of this study are to develop and test the optimal exercise dosage and sequence for reducing vat in overweight and obese community residents. purposive sampling will be used to enroll at least 206 participants aged 40-65 years and body fat more than 30% without diet control from 2 community centers in southern taiwan. the project will use the sequential multiple assignment randomized trial (smart) design to conduct a 16-week 2-stage (each for 8-weeks) adaptive exercise intervention for community residents. in the first stage, participants will be randomized into groups performing 8 weeks either moderate intensity of aerobic exercise or interval training 3 times per week. participants whose vat does not decrease by over 3%, measured using a body composition analyzer, compared with the baseline will be 1:1 rerandomized into groups with aerobic exercise combined with resistance exercise or received the exchange of first stage treatment (interval training or aerobic exercise) in the second stage. those with substantial response to the first-stage intervention (vat reduction of more than 3%) will continue to receive the same exercise treatment until 16 weeks. linear mixed model, weighted and replicated regression will be used to identify the optimal sequence of exercises for the greatest reduction in vat. the findings can assist clinical health workers to develop exercise prescriptions for effectively reducing vat, and help community residents reduce vat through exercise to achieve the health promotion.


Eligibility criteria:
inclusion criteria: * community residents (a) who are 40-65 years old without diet control, (b) body fat ≧ 30% measured by body composition analyzer, and (c) can communicate in mandarin or taiwanese will be included. exclusion criteria: * this study will exclude residents with (a) recent unstable condition involving stroke or those with heart disease, handicap, pregnancy, mental disorders, systolic bp \> 200 mmhg, or diastolic bp \>110 mmhg; and (b) those with contraindications in body composition analyzer measurement including people with pacemakers, artificial metal joints, amputated hands or feet, and those who cannot be cooperated with standing during testing.

Keywords: sequential multiple assignment randomized trial exercise visceral adipose tissue
thrombotic effects of yellowstripe scad

Conditions: Thrombosis

Summary: the study aimed to determine the thrombotic effects of yss compared with salmon among healthy overweight subjects. it hypothesized that yss may result significant, favorable thrombotic effects and the effects may be similar with salmon.

the project was a randomized, two-period, crossover trial with 8-week treatment periods and 8-week washout period. a total of 50 healthy overweight adults were recruited among staff and students in upm. all the subjects were randomized into two groups. each group was served with either cooked yss (\~265 g/ day) or salmon (\~246 g/day) thrice per week. blood and urine samples were collected for laboratory assessment.

Eligibility criteria:
inclusion criteria: * malaysian * overweight participants (bmi 23-27.4 kg/m2) exclusion criteria: * regular use of fish oil supplements during the last one month * regular consumption of fish twice or more per week * vegetarian who excluded all meat, fish, and poultry from their diet * diagnosed with cardiovascular disease, haemostasis disorder, inflammatory disease, diabetes mellitus, hypertension, or other significant medical history that may prohibits the participation * receiving warfarin or aspirin treatment, or medication to lower serum lipids, blood pressure, and inflammation * women who are menopause, pregnant or lactating

Keywords: thrombosis yellowstripe scad salmon healthy overweight subjects randomized crossover trial
efficacy and safety study of soluble beta-1,3/1,6-glucan (sbg) versus placebo in chronic diabetic foot ulcers

Conditions: Diabetes; Diabetic Ulcer

Summary: evaluation of efficacy and safety of sbg vs placebo in the treatment of chronic diabetic foot ulcers.

the objective of this study is to evaluate efficacy and safety of soluble beta-1,3/1,6-glucan (sbg) on chronic diabetic foot ulcers.

Eligibility criteria:
inclusion criteria: * patients with chronic diabetic foot ulcer exclusion criteria: * insufficient nutritional status, renal function or diabetes control

Keywords: diabetes diabetic ulcer chronic ulcer sbg
study on the mechanism of ganoderma lucidum spore powder in the treatment of depression

Conditions: Depression; Thyroid Cancer

Summary: to clarify the clinical effect of ganoderma lucidum spore powder intervention on postoperative depressive symptoms of papillary thyroid carcinoma ; to elucidate the antidepressant mechanism of ganoderma lucidum spore powder.

after being informed of the study and potential risks, all patients who gave written informed consent were enrolled. a total of 300 eligible patients were randomly assigned in a double-blind manner and divided into experimental group and control group at a ratio of 2 : 1. the subjects were given oral test drugs ( ganoderma lucidum spore powder or placebo ) 4g per day for 90 days from the first day after enrollment.

Eligibility criteria:
inclusion criteria * patients with depressive symptoms after surgery for papillary thyroid carcinoma in the outpatient department of zhejiang cancer hospital * han nationality * no previous depression and other mental diseases * 18-80 years old * women * bmi 19 \~ 24 exclusion criteria * suffering from other diseases of the intestinal system * gastrointestinal surgery was performed before intervention * including patients with other malignant tumors, who need chemotherapy, radiotherapy, biological therapy or traditional chinese medicine treatment received antibiotics or microecological modulators within 3 months before the intervention * acute intestinal obstruction * patients with severe depressive symptoms who must receive antidepressant treatment organic diseases such as heart and brain diseases, brain trauma history of mental illness, use of psychoactive drugs such as drugs * severe liver and kidney dysfunction * pregnancy, lactation

Keywords: depression thyroid cancer the gut-brain axis ganoderma lucidum
injecting drug use community intervention trial

Conditions: HIV; Hepatitis C; Syphilis; HSV-2; HIV Infections

Summary: the purpose of this study is to reduce the hiv/hcv incidence among the clients attending community-based methadone maintenance treatment (mmt) , and to prevent the secondary sexual transmission from hiv+ clients to their spouse and sex partners, through intensified comprehensive intervention.

even though national sentinel surveillance data show that the increase rate of hiv new infections among idus in china has become stabilized and slowed down, the new hiv infection is still on the rise, especially in the yunnan, guizhou, guangxi, xinjiang and sichuan. this study attempts to further reduce the new infection among mmt clients, and particularly to prevent the transmission from hiv infected clients to their sexual partners with comprehensive intervention. the purposes of this study are: 1. to evaluate the effectiveness of comprehensive interventions to decrease the hiv/stis incidence among mmt clients. 2. to prevent the sexual transmission between those hiv+ clients and their spouse/partners with intensified intervention.

Eligibility criteria:
(1) for mmt clients: inclusion criteria: * 20 years or above and have independent capacity of civil conduct. * those have enrolled in mmt clinics more than one month, and progressed to the phase of maintenance treatment. * no mental and other physical diseases * more than 6-month stay at local places and registered at the designated clinics. * complete informed consent exclusion criteria: * fail to complete informed consent * temporarily transit in or out of the designated clinic. * those have enrolled in mmt clinics less than one month, and haven't progressed to the phase of maintenance treatment. * with serious mental or other physical diseases for the spouse or sex partners of mmt hiv+ clients' inclusion criteria: * 20 years or above and have independent capacity of civil conduct. * keep fixed sexual contact with hiv+ clients in the recent 6 month * no mental and other physical diseases * more than 6-month stay at local places and be able to participate the 1 year follow up. * complete informed consent * the recent hiv test is negative exclusion criteria: * fail to complete informed consent * temporarily transit in or out of the designated clinic. * with serious mental or other physical diseases * the recent hiv test is positive

Keywords: methadone maintenance treatment drug users heroin hiv hcv syphilis hsv-2
the beijing randomized study of prostate cancer screening

Conditions: Prostate Cancer

Summary: bropcs is a randomized trial study comparing the effectiveness of traditional systematic biopsies and bpmri followed targeted biopsies with psa \> 4ng/ml in initial screening.

the aim of bropcs study is to explore a suitable prostate cancer screening model for chinese population, which can increase the specificity in early detection of prostate cancer without decreasing the sensitivity of clinically significant prostate cancers, and can reduce prostate cancer-specific mortality.this study will use a cluster randomized controlled trial method with a total of approximately 30,000 participants. the subjects will be randomly assigned to a control group (about 20,000 people) and a screening group (about 10,000 people), and some basic information will be obtained through a questionnaire survey. the screening group will undergo initial prostate-specific antigen (psa) screening, and high-risk subjects (psa \> 4ng/ml) will be randomly assigned to two groups. the standard biopsy group will undergo traditional systematic biopsy, while the precision screening group will undergo further mri examination and targeted fusion biopsy for those with positive mri results.

Eligibility criteria:
inclusion criteria: 1. healthy men aged 60-75 with a life expectancy of more than 10 years; 2. residing continuously in the community for more than 3 years and not previously diagnosed with prostate cancer; 3. willing to participate in this project. exclusion criteria: 1. previously diagnosed with prostate cancer; 2. previously diagnosed with any malignant tumor within the past 5 years; 3. used medication within the past 3 months that can affect psa values, mainly finasteride, dutasteride, and ketoconazole; 4. recently had acute prostatitis, acute urinary retention, or underwent transurethral procedures (such as urethral dilation, urinary catheterization, cystoscopy, etc.) within the past week; 5. have other serious illnesses or cannot perform activities of daily living independently.

Keywords: prostate cancer mri biopsy
treatment of functional dyspepsia with acupuncture

Conditions: Functional Dyspepsia

Summary: functional dyspepsia (fd) is one of the most common chronic gastrointestinal disorders affecting humans. existing therapies for fd are still far from satisfactory and new therapies are constantly being sought. acupuncture has been used for the alleviation of functional gastrointestinal symptoms in several non-controlled studies. this study aims to investigate the therapeutic efficacy of acupuncture in patients with fd.


Eligibility criteria:
inclusion criteria: - female and male patients with functional dyspepsia between the ages of ≥18 and ≤70 years. fd will be diagnosed according to the rome-iii criteria. onset of fd symptoms should begin at least 6 months before clinical presentation and must be fulfilled for the last 3 months and his or her fd symptoms score must be of at least moderate severity. exclusion criteria: * subjects unable to give informed consent * pregnant or breast-feeding females or women who get pregnant midway * subjects who have received acupuncture treatment before * subjects who have had a previous gastrointestinal surgery except appendectomy and laparoscopic cholecystectomy * any significant past or concurrent disease or disorder which, in the opinion of the investigator, may either put subject at risk in the study, influence the results of the study or influence subject's ability to participate in the study * maintenance treatment with ppis (proton pump inhibitors) and h2ras (h2-receptor antagonists) continuously (every day) in the last 6 months prior to entry into the study * treatment with ppis and h2ras, prokinetics, antibiotics, prostaglandins or bismuth-containing compounds during the last 2 weeks prior to entry into the study * h. pylori eradication treatment within the past 12 months before study start * h. pylori positive patients * patients with bleeding diathesis * known or suspected hypersensitivity to acupuncture.

Keywords: functional dyspepsia acupuncture traditional chinese medicine
chronic remote ischemic conditioning to modify post-mi remodeling

Conditions: Myocardial Infarction

Summary: during a heart attack, an artery carrying blood and oxygen to the heart becomes blocked, which causes damage to the heart muscle. when possible, a clot-busting drug is given or a procedure called angioplasty is performed soon after a heart attack starts, to open up the blocked artery and restore blood flow to the heart. while this can be an effective treatment to reduce permanent damage to the heart, patients can still experience heart failure afterwards. consequently many patients require medications to support their heart after a heart attack. recent research has shown a new technique called remote ischemic conditioning or ric, is effective at protecting the heart muscle in a heart attack. ric is produced simply by repeated inflation and deflation of a blood pressure cuff on an arm or leg to temporarily cut off and then restore blood flow to that limb. the investigators believe this triggers the release of molecular factors that protect heart muscle. in a recent study in humans, it reduced the amount of permanent damage to the heart muscle when applied before the angioplasty procedure. the investigators recent animal studies have shown that ric may also help the heart muscle recover after a heart attack if applied everyday during the month after a heart attack, by preventing heart failure. this is important for two reasons: first, currently the investigators can only treat heart failure with medications, and second, some people have heart attacks but are not suitable to have angioplasty and so are at greater risk of heart failure. daily ric may provide an easy and effective new treatment to prevent heart failure after a heart attack. this application proposes a preliminary study in humans to see if daily ric can help heart muscle recovery after a heart attack.


Eligibility criteria:
inclusion criteria: (i) admitted for primary pci for stemi involving the lad within 12 hours of onset of symptoms. stemi will be defined as typical ecg changes (st segment elevation ≥2mm in 2 or more precordial leads) associated with acute chest pain or an elevation of cardiac enzymes; (ii) antegrade timi 0 or 1 prior to pci; (iii) age ≥18 years; (iv) informed consent from patient or next of kin. exclusion criteria: (i) known history of diabetes; (ii) coronary anatomy warranting emergent coronary artery bypass graft surgery; (iii) mechanical complication of stemi (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation); (iv) need for hemodialysis; (v) malignancy, hiv, or central nervous system disorder; (vi) cardiopulmonary resuscitation \>15 min and compromised level of consciousness; (vii) cardiogenic shock; (viii) current participation in any research study involving investigational drugs or devices; (ix) inability to safely undergo cmri

Keywords: remote ischemic conditioning pci stemi lad
expanded access [11c] methionine pet imaging

Conditions: Central Nervous System Tumor; Head and Neck Neoplasms

Summary: the participants are being asked to get this pet scan because the participants have or may have cancer in the central nervous system (head, neck, or spine), and the investigator and the patient's physician thinks that this scan may provide useful information for the participant's treatment. primary objective to provide expanded access to l-\[11c\]methionine as a positron-emitting tracer in children and young adults for the positron emission tomography (pet) imaging of neoplasms of the central nervous system (cns) and head and neck to guide therapeutic management of disease.

participants receive an intravenous injection of a small (tracer) dose of l-\[11c\]methionine. approximately 10 minutes later, patients undergo pet scanning to evaluate localization of the tracer.

Eligibility criteria:
inclusion criteria: * all participants under the care of a sjcrh physician with known or suspected neoplastic disease of the cns or head and neck are eligible for participation. * no limit on age. * patients of all genders and all ethnic groups under the care of a sjcrh physician. * female participants of child-bearing age must not be lactating due to theoretical potential harm to the infant from exposure to radiation. * informed consent signed by participant, parent, or guardian according to the guidelines of the institutional review board. exclusion criteria: * more than six l-\[11c\]methionine pet scans within the previous 12 months. * inability or willingness of patient, parent, or guardian to consent.