Kornimate/medical-research-clean huggingface dataset:
evaluation of postoperative pain after single visit retreatment of symptomatic and asymptomatic teeth

Conditions: Post-operative Pain; Retreatment; Symptomatic Periapical Periodontitis; Endodontic Disease; Asymptomatic Periapical Periodontitis

Summary: introduction: the aim of this study comparing the post operative pain after the retreatment of asymptomatic and symptomatic teeth that during single visit treatment with rotary and reciprocal nickel titanium files. methods: one hundred and forty one patients scheduled for non-surgical endodontic retreatment were included for evaluation. eighty five patients who needed endodontic retreatment were assingned to 2 groups according to semptomatic or asemptomatic teeth and 4 subgroups with rotary and resiprocal files. endodontic filling material was removed with one flare and micromega remover files in the retreatment kit. patients then recorded their postoperative pain on a vas scale at 24h, 48h, 72h, 7 days and 14 days post-treatment. results were analyzed using the shapiro-wilk, mann-whitney u, kruskal-wallis, dunn-bonferroni and pearson chi-square tests.

retreatment is the procedure performed to regain healthy periapical tissues that the teeth have undergone root canal treatment are re-infected due to apical or coronal leakage, or after an inadequate root canal treatment. when primary root canal treatment fails, the first treatment option is non-surgical retreatment to eliminate the infection. in general, the reported success rate of retreatment ranges from 62% to 91%. this randomized clinical study's primary goal is to evaluate the postoperative pain following a single visit of root canal retreatment for asymptomatic and symptomatic mandibular premolars using reciprocal and rotary file systems. therefore, this study aims to compare the effect of one curve mini (rotary file system) and one reci (resiprocal file system) nickel-titanium file systems on postoperative pain after non surgical endodontic retreatment within symptomatic and asymptomatic teeth.

Eligibility criteria:
inclusion criteria: * symptomatic apical periodontitis * asymptomatic apical periodontitis * adult patients between 18-67 years aged exclusion criteria: * patient under 18 years old * complicating systemic disease * allergies to local anesthetic agents * acute apical abscesses * periodontal pockets deeper than 5 mm or more mobilty than level 1 * bruxist and teeth-grinding patient * pregnant women * presence of external root resorption * root fracture * root perforation * calcified root canals

Keywords: post-operative pain minimal invasive files single visit retreatment remover files
effect of probiotics in reducing infections and allergies in young children starting daycare

Conditions: Days Absent From Daycare; Respiratory Tract Infections; Gastrointestinal Infections; Allergy

Summary: the aim of the intervention is to examine the effect of a combination of the two bacterial strains bb-12 and lgg, provided for 6 month, on the prevalence of infections and allergic manifestations in small children, and how a combination of bb-12 and lgg affects the immune system, gastrointestinal tract and the microbiota. children are enrolled during 2 winter seasons.


Eligibility criteria:
inclusion criteria: * expected to start daycare between the age of 8-14 month * intervention start 0 days to 12 weeks before starting daycare * expected to start daycare from september to february (both month included) * single born exclusion criteria: * exclusion criteria: * children born before 37th gestational week * children with a birth weight \< 2500 g * children suffering from severe chronic illness * children receiving regular medication * children who have received antibiotics within a month before intervention start * children whose parents do not speak danish

Keywords: infections allergy immune function microbiota infant
mobile stress management program for african american women

Conditions: Psychological Stress

Summary: the unjust social, economic, and environmental conditions that african americans face throughout their lives lead to pervasive health disparities. these disparities are driven by healthcare differences. they are driven by economic differences. those with less financial wealth have poorer health as compared to those with higher socioeconomic status. and yet, even when controlling for these two important social determinants of health, race still predicts morbidity and mortality. what can account for this? stress. african americans experience more stress than their white peers. the story is even more dire for african american women who simultaneously face both racial discrimination and sexism. indeed, gendered racial discrimination is nearly ubiquitous for black women at all socioeconomic levels. it is also a distinct form of stress, with unique outcomes compared to other non-race-or-gender-related stressors. finally, stress has clear downstream negative effects on health. at present, there is no mobile cognitive-behavioral stress management intervention (m-cbsmi) designed to help african american women manage racial and nonracial daily stress. the investigators intend to fill this void. using proven cbsmi techniques, participants will learn how to manage their stress through text messages and integrated mobile web content. supportive texts will inspire, motivate, and affirm the life experiences of participants. educational texts will increase knowledge, develop skills, and reduce barriers to adaptive coping. a library of individually tailored videos will be delivered to each participant. all mobile web content will be accessible only through touch-based links embedded within text messages, making it easy and effortless to view this material. during phase ii the investigators will complete development of the m-cbsmi. then, the investigators will examine the effectiveness of the m-cbsmi to reduce stress among african american female participants. participants will be randomly assigned to either the intervention condition or to a matched control condition. secondary measures will assess coping, well-being, subjective health, gendered racial identity, and knowledge.


Eligibility criteria:
inclusion criteria: * self-identify as black; own a smartphone; have at least limited english literacy skills; report perceived discrimination; and be moderately stressed. the discrimination must be due to race or gender and the frequency must be at least "a few times in the past year" or more. in addition, they must report a score of 6 or higher on the 4-item perceived stress scale (pss). exclusion criteria: -
effect of s. aureus skin decolonization on disease severity in atopic dermatitis patients

Conditions: Atopic Dermatitis

Summary: our hypothesis is that s. aureus skin decolonization in atopic dermatitis reduces disease severity and favorably alters the function and gene expression of epidermal and immune skin cells that contribute to disease severity.

patients will sign an informed consent and assent to participate. skin and both nares will be cultured for s aureus. a blood sample and two 2 mm skin biopsies will be obtained one from non-lesional skin and another one from lesional skin). the patients will be instructed in the use of the three-week s. aureus decolonization regimen and provided with the medications (sulfamethoxazole/trimethoprim and mupirocin ointment) and chlorhexidine. the second visit will take place immediately at the end of the three-week s. aureus skin decolonization regimen. disease severity will be assessed, the skin and nares will be re-cultured, and skin biopsies and blood will be obtained.

Eligibility criteria:
inclusion criteria: 1. male or female participants ≥6 yrs of age 2. meet atopic dermatitis standard diagnostic criteria 3. scorad \> 40. exclusion criteria: 1. . enrollment in another clinical trial 2. hypersensitivity to an agent used for the skin decolonization protocol 3. use within 4 weeks of systemic treatment with immunosuppressive/immunomodulating drugs (corticosteroids, cyclosporine, mycophenolate, azathioprine, methotrexate) 4. phototherapy for ad within 4 weeks 5. treatment with biologics (dupilumab, omalizumab, benralizumab, etc) within sixteen weeks 6. use of topical steroids, topical calcineurin inhibitors within 7 days 7. bleach baths within 7 days of the first visit 8. use of oral or topical antibiotics within 21 days of the beginning of the study 9. asthmatics receiving more than 500 μg per day of inhaled corticosteroids 10. history of (hiv, hepatitis b, hepatitis c, tuberculosis malignancy 11. skin comorbidities that may interfere with assessments: psoriasis, cutaneous t cell lymphoma,, 12. severe ongoing medical illnesses e.g. cardiovascular, renal disease, autoimmune disease. 13. febrile illness at time of visits 14. suspected immune deficiency or family history of primary immunodeficiency 15. pregnancy
effect of music therapy on families of burn patients

Conditions: Burns

Summary: the purpose of this study is to investigate the efficacy of music therapy in assisting with the coping and adjustment of children of adults with major burns. the investigators hypothesized that there will be a significant decrease in anxiety levels between those children who participated in music therapy compared to non-participants.

the sound of family together (s.o.f.t.) music program was introduced on a 14-bed burn intensive care unit to provide an avenue for communication between adults with major burns and their children. in adherence with unit policies, children under the age of 16 are only allowed onto the unit under very special circumstances, e.g. patient is under dnr status. this restriction may translate into a prolong absence between the patients and their young children; which may result in emotional and psychological stress factors such as separation anxiety, feelings of abandonment, and rejection of the parent when the patient is being discharged to home. children who participate in the s.o.f.t. music program will record and produce an audio cd for their hospitalized parent/grandparent. the contents of the cd might include original songs, poems, and special messages created by the children. pre and post tests results will determine the efficacy of the program to decrease anxiety levels in the children.

Eligibility criteria:
inclusion criteria: * child's age between 6 - 14 years * child or grandchild of patient * child with limited visitation * adequate hearing, with correction * consenting non-hospitalized adult family member (nhafm) speak/read english * child speak/read english * major physical or mental illness or disability does not interfere with ability to communicate for both consenting nhafm and child exclusion criteria: * child's age below 6 years and above 14 years * not the child or grandchild of patient * child with unlimited visitation * hearing loss that interferes with ability to communicate * nhafm does not speak/read english * child does not speak/read english * major physical or mental illness or disability interferes with ability to communicate for both consenting nhafm and child * patient on observation status, i.e. only one overnight stay

Keywords: psychological adjustment of family family of patients children of patients intensive care unit burn music therapy music music program anxiety coping adjustment psychological stressor emotional stressor
comparison of conventional and cooled radiofrequency ablation in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the aim of this study was to examine and compare the effects of conventional and cooled radiofrequency ablation on pain and disability levels in patients with knee pain resistant to other treatments due to knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * knee pain lasting more than 6 months * age between 50 and 80 * diagnosis of radiographically proven grade iii or iv knee osteoarthritis according to the kellgren-lawrence grading scale, marked narrowing of the medial compartment of the tibiofemoral joint space * presence of pain resistant to conservative treatment * exercise * physical therapy agents * use of oral anti-inflammatory agents exclusion criteria: * history of trauma to the knee area * history of knee surgery * presence of systemic inflammatory disease affecting the knee joint * presence of peripheral neuropathy or radiculopathy * pregnancy * hemodynamic instability * presence of skin or soft tissue infection at the injection site * refusal to participate in the study * presence of acute knee pain with accompanying inflammatory findings * presence of a serious psychiatric disorder or neurological disease having received an intra-articular injection within the last 3 months
haemodialysis outcomes & patient empowerment study 02

Conditions: End Stage Renal Disease; Dialysis; Complications; Volume Overload

Summary: pilot-scale, single-arm,observational study to assess the utility and acceptability of a wearable hydration monitor in haemodialysis patients compared with bioimpedance and haemodialysis machine data.

pilot-scale, single-arm,observational study to assess the utility and acceptability of a wearable hydration monitor in haemodialysis patients compared with bioimpedance and haemodialysis machine data. the sixty device uses diffuse reflectance spectroscopy to measure fluid status. 20 patients will be assessed during the study observation period. 10 patients undergo an observation period of approximately three weeks. the patients will be asked to wear the sixty device during dialysis and at night throughout the study observation period. following the completion of this 3 week observation period, an additional 10 patients will wear the sixty device as per the protocol for 3 weeks. haemodialysis parameters will be assessed as usual during the study. bioimpedance measurements will be taken pre and post-dialysis once weekly during the mid-week dialysis session: patient-reported symptoms related to haemodialysis will be recorded, including symptoms of hypervolaemia and hypovolaemia.

Eligibility criteria:
inclusion criteria: * on haemodialysis in an ambulatory care setting. * demonstrates understanding of correct use of the sixty device. * capable and willing to measure blood pressure at home on a daily basis. * willing to give written informed consent. exclusion criteria: * conditions precluding use of bioimpedance (e.g. implantable cardioverter defibrillator, pacemakers, hearing aids, pregnancy). * significant confusion or any concomitant medical condition, which would limit the ability of the patient to record symptoms or other parameters.

Keywords: sensor volume overload dialysis bioimpedance
hybrid capture 2 human papiloma virus (hpv) high-risk anal dna test

Conditions: Anal Canal HPV Infection Diagnosis; Anal Dysplasia Diagnosis; Anal Cancer

Summary: this is a study to determine if hc2 hpv testing in the anal canal can detect high-risk hpv and whether this aids in identifying individuals are risk for anal cancer or precancerous lesions.


Eligibility criteria:
inclusion criteria: 1. male or female 18 years of age or older 2. screened for anal dysplasia, including msm and women - exclusion criteria: 1. subject has had a previous treatment for anal cancer. 2. subjects that have used enemas or other foreign substances, in the anal canal or anal sex within 24 hours of collection. 3. subjects that have bleeding disorders or use anticoagulation treatments. -

Keywords: anal hpv anal dysplasia ana cancer
trends: a prospective study of the clinical significance of atrial arrhythmias detected by implanted device diagnostics

Conditions: Atrial Fibrillation; Stroke; Heart Failure

Summary: the purpose of this study is to look at the heart rate and rhythm information collected daily in medtronic implantable pulse generators (ipg), implantable cardioverter defibrillators (icd) and cardiac resynchronization therapy (crt) devices. the study will gather this information from many patients to see if heart rate or rhythm data can predict the risk of a patient having a medical condition such as stroke.


Eligibility criteria:
inclusion criteria: * subject provides written informed consent and privacy/protection authorization. * subjects 65 years of age or older. or * subjects with age \>18 and \< 65 years and one of the following stroke risk factors: * prior stroke or tia * diagnosis of hypertension (htn) * diagnosis of diabetes mellitus (dm) * diagnosis of congestive heart failure (chf) * subjects who meet the class i/class ii indications for a dual chamber implantable pulse generator or dual chamber implanted cardioverter defibrillator device or • subjects who meet the criteria for indication of a dual chamber resynchronization device with bi-ventricular pacing (moderate to severe chf symptoms \[nyha class iii-iv\] despite optimal medical therapy, left ventricular ejection fraction ≤ 35%, and a qrs duration ≥130 ms)13. exclusion criteria: * subjects who are to receive a replacement ipg, icd or crt device. * subjects with chronic (permanent) at/af. * subjects with a history of av nodal dependent arrhythmias. * subjects with a terminal illness who are not expected to survive more than 6 months. * subjects who are unwilling or unable to cooperate or give written informed consent and privacy/protection authorization, or subjects whose legal representatives or legal guardians refuse to give informed consent or privacy/protection authorization. * subjects currently receiving treatment in another drug and/or device study which could affect the outcome of the trial. * subjects who are or will be inaccessible for follow-up at a qualified study center.

Keywords: atrial fibrillation stroke pacemaker implantable cardiac defibrillator resynchronization systems
bupivacaine epiphora trial

Conditions: Epiphora; Ptosis

Summary: the objective of this study is to investigate quantitative improvement in excessive tearing after administration of bupivacaine, a local anesthetic, into the affected eyelids.


Eligibility criteria:
inclusion criteria: patients age 18 and above, patients with unilateral or bilateral excessive tearing. exclusion criteria: pregnant females, vulnerable populations, patients with severe hepatic disease, or patients using monoamine oxidase inhibitors or tricyclic antidepressants, which are contraindicated with bupivacaine and norepinephrine combinations.
news and rapid lactate testing for early identification of high risk patients in the emergency department

Conditions: Triage Category 3 (Urgent)

Summary: to validate the news and rapid lactate testing for early identification of high risk \[triage category 3 (urgent)\] patients in the emergency department. to compare qsofa and sirs criteria in patients in the emergency department.

background: sepsis is a potentially life-threatening complication of an infection. early identification and early intervention are two main elements in improving patient care. objectives: 1. to validate the news and rapid lactate testing for early identification of high risk \[triage category 3 (urgent)\] patients in the emergency department. 2. to compare qsofa and sirs criteria in patients in the emergency department. study design: this is a prospective, cohort study. patients aged 18 or above presenting to the ed triaged as category 3 (urgent) will be recruited. the required data for calculating news will be collected at triage and triage lactate level will be measured by point-of-care analyzer. outcomes: the primary outcome is referral for intensive care unit (icu) admission during the patient's ed stay. the secondary outcomes are length of stay in hospital (los), hospital admission, admission to icu, length of icu-free admission (defined as days alive outside the icu from admission to day 30) 30-day mortality and time to processes-of-care.

Eligibility criteria:
inclusion criteria: * aged 18 years or above who are triage category 3 in emergency department * presenting to emergency department between 9am and 4pm, monday to friday exclusion criteria: * aged below 18 years * pregnant

Keywords: national early warning score (news) lactate emergency department
distal radial access for primary pci in stemi patients to prevent rao

Conditions: ST Segment Elevation Myocardial Infarction

Summary: randomized-controlled trial to compare early radial artery occlusion via distal vs. conventional transradial access among st segment elevation myocardial infarction patients for primary percutaneous coronary intervention.

conventional transradial access (tra) is recommended as the default approach for patients undergoing percutaneous coronary intervention (pci) according to 2018 esc guidelines. however, radial artery occlusion (rao) remains the frequent complication, precluding the future use of the radial artery as an access point for repeat coronary recanalization or as a conduit for coronary artery bypass surgery. more than 50% of patients with st segment elevation myocardial infarction (stemi) present multiple vascular lesions, of which 50% require reprocessing non-culprit vessels. therefore, the patency of the radial artery is crucial for stemi patients. the distal radial access (dra), located in the anatomical snuffbox or the dorsum of the hand, was introduced as a promising alternative. three recent rcts have shown significant reductions of rao after dra compared with tra. nevertheless, all of them excluded the patients presenting with stemi. therefore, we conduct a prospective, single-center, open-label randomized clinical trial to assess the superiority of preventing rao at 24 h via dra when compared tra among stemi patients for primary pci.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * st-segment elevation myocardial infarction for primary percuteous coronary intervention * palpable pulses on both access sites of the radial artery * informed consent exclusion criteria: * thrombolysis before primary percutaneous coronary intervention * previous cabg or radio-cephalic fistula using radial artery * cardiogenic shock * severe arrhythmias * severe liver and kidney dysfunction * pregnancy * enrolment in another study within 1 month * inability to obtain written informed consent

Keywords: radial artery occlusion primary percutaneous coronary intervention distal radial access conventional transradial access