Kornimate/medical-research-clean huggingface dataset:
olmesartan medoxomil in hypertension and renal impairment

Conditions: Essential Hypertension; Renal Impairment

Summary: this is a study in hypertensive patients with mild to moderate renal impairment. the antihypertensive efficacy of olmesartan medoxomil is compared to losartan.


Eligibility criteria:
inclusion criteria: * mean sitting bp prior to randomization of 140-180/90-109 mmhg; * renal impairment prior to randomization of mild (50 ≤ clcr ≥ 80 ml/min) to moderate (30 ≤ clcr ≥50 ml/min) severity exclusion criteria: * malignant hypertension or sitting bp greater than 180/109 mmhg; * severe heart failure, severe renal disease; * recent history of myocardial infarction, stroke or transient ischemic attack; * history, clinical or current evidence of any significant gastrointestinal, respiratory, hematological, metabolic, immunological or any other underlying disease which in the opinion of the investigator would interfere with the patient's participation in the trial; * hypersensitivity or contraindications to arbs or ace inhibitors or any cross allergy; * treatment with dis-allowed medication; * pregnant or breastfeeding females or females of childbearing potential without adequate contraception; * history of drug and/or alcohol abuse
pre-operative sonographic assessment of the median nerve in carpal tunnel syndrome. does it affect the operative procedure?

Conditions: CTS

Summary: sonographic assessment of the median nerve in carpal tunnel syndrome to assess the surgical importance and added value of superficial ultrasonography in assessment of the median nerve in cts.

abstract objective: to assess the surgical importance and added value of superficial ultrasonography in assessment of the median nerve in cts. methods: the study was conducted on thirty patients with cts with electrophysiological confirmation; twelve males and eighteen females with mean age 43.93±4.51 (range 35-52y), and another thirty normal subjects; fifteen males and fifteen females, with their mean age 36.7±4.86 (range 29-45y). the cross sectional area (csa) and flattening ratio (fr) at different levels were measured on both groups. data from the study and control groups were compared. the accuracy of the ultrasonographic diagnostic criteria for cts was evaluated using receiver operating characteristic (roc) analysis. all the patients had surgical carpal tunnel release and the operative details were correlated with the ultrasonographic data.

Eligibility criteria:
inclusion criteria: * carpal tunnel syndrome exclusion criteria: * bifid median nerve, carpal tunnel mass lesions, persistent median artery

Keywords: ultrasonography carpal tunnel syndrome
reducing indoor allergen exposures in northern manhattan and the south bronx

Conditions: Asthma; Allergy

Summary: controlled trial of an intervention to reduce indoor exposures to cockroach allergens among asthmatic children in nyc.


Eligibility criteria:
ages 6-18 doctor-diagnosed asthma skin-test reactivity to cockroach antigen daily cockroach sitings in home

Keywords: asthma allergen cockroach
sedpark2: post marketing surveillance to observe safety and efficacy of piribedil in parkinson's disease (pir-002/k)

Conditions: Parkinson's Disease

Summary: the objective of the post marketing surveillance study is to investigate the use of the non-ergot dopamine agonist piribedil (trade name: clarium) in mono- and combination therapy in patients with morbus parkinson. neurologists in private practices in germany should document the safety and course of the disease/change of parkinsonian symptoms during stabilisation on, or change over from other dopamine agonist treatment under routine conditions. piribedil should be prescribed according to its marketing authorisation.


Eligibility criteria:
inclusion criteria: * male and female patients 18 years and older. * indication: morbus parkinson. * treatment with piribedil for the first time. * monotherapy with piribedil. * combination therapy with l-dopa (from the beginning or secondary in combination with other antiparkinsonian drugs). exclusion criteria:

Keywords: piribedil (trade name: clarium) non-ergot dopamine agonist morbus parkinson tolerability efficacy post marketing surveillance
restart the prevention of pressure ulcers: comparing the effectiveness and cost of a reactive static air mattress and alternating air pressure mattress

Conditions: Pressure Injury; Pressure Ulcer; Decubitus Ulcer

Summary: pressure ulcers are a global issue and substantial concern for healthcare systems. a review of the literature between january 2000 and december 2012 has revealed that prevalence rate of pressure ulcers in aged care facilities were between 4.1% and 32.2%, and the incidence rates ranged from 1.9% to 59%. similarly, a systematic review reported that the prevalence of pressure ulcer varied between 0.3% and 46%, and the incidence of pressure ulcer ranged from 0.8% to 34%. most epidemiological data were obtained from hospitals (38.7%) and institutional long-term care facilities (29.7%). the costs associated with pressure ulcers are considerable. according to the agency for healthcare research \& quality (2011), the us healthcare system has allocated approximately $ 9.1 - $ 11.6 billion annually for the health care cost of pressure ulcer. in addition to direct treatment-related costs, the development of pressure ulcer also results in litigation and government penalties, and affects hospital performance metrics. a systematic review has reported that the cost for treatment of pressure ulcer was higher than its prevention. that is, the cost per patient per day ranged from € 1.71 to € 470.49 (for treatment) and from € 2.65 to € 87.57 (for prevention) across all settings. this randomized controlled trial will be performed in a general hospital in a random sample of 308 patients (nursing wards geriatric n=3 and orthopedic (n=3)) who are at high risk of developing pressure ulcers. patients will be included in the study for a period \> 2 hospitalisation days. skin assessment and risk factor registration will be done on a daily base by the ward nurses. reliability checks and time measurements will be completed by the researcher.


Eligibility criteria:
inclusion criteria: * norton score \< 14 * bed and/or chairfast * no pressure ulcers or at least pressure ulcer category i exclusion criteria: * norton score \>/=14 * pressure ulcers category ii, iii, iv, deep tissue injury (dti) or unstageable pressure ulcer * expected length of hospital stay \< 2 days * medical contraindication for use of reactive static air support surfaces * end of life care (or do not reanimate (dnr) code iv) * age \< 18 years
survey on epidemiology of hypoparathyroidism in france

Conditions: Hypoparathyroidism

Summary: very few data has been published on the epidemiology of hypoparathyroidism worldwide: none exists specifically for france. hypoparathyroidism could led to complications. here, the investigators plan to collect data about both epidemiology, medication and complication of hypoparathyroidism in france.

very few data has been published on the epidemiology of hypoparathyroidism worldwide. none exists specifically in france. hypoparathyroidism could led to complications: e.g. symptomatic hypocalcemia, calcifications (brain, eye and other soft tissues), nephrolithiasis/nephrocalcinosis, renal insufficiency. here,the investigators plan to collect data about both epidemiology, medication and complication of hypoparathyroidism in france.

Eligibility criteria:
inclusion criteria: * patient fro whom chronic hypoparathyroidism is diagnosed * patient living in france exclusion criteria: * patient who does not want his data to be collected in this registry * pseudo-hypoparathyroidism * acute hypoparathyroidism

Keywords: hypoparathyroidism epidemiology medication therapy management
efficacy and safety of photodynamic therapy for cin3

Conditions: Precancerous Cervical Lesion

Summary: to investigate the efficacy and safety of photodynamic therapy (20% 5-amino-ketovalerate 630nm red light) in the treatment of cervical intraepithelial neoplasia 3(cin 3)in women in the real world


Eligibility criteria:
inclusion criteria: * cin3, photodynamic therapy was required, * type 1 2 transformation area, colposcopy was sufficient * the lesion boundary was completely visible * the ecc did not indicate high-grade lesions exclusion criteria: * coexistence or suspicion of cancer; * tct hsil * involving glands * porphyria patients, or suspected allergic to red and blue light. * severe medical comorbidities；

Keywords: pdt hpv cin 3
liver transplantation and metastatic colo-rectal cancer.

Conditions: Colo-rectal Cancer

Summary: survival of colo-rectal cancer patients after liver transplantation.

survival, time to progression, other malignancy, side-effects, quality of life.

Eligibility criteria:
inclusion criteria:colo-rectal cancer - exclusion criteria: -

Keywords: liver transplantation
effect of sinc feeding protocol on weight gain, transition to oral feeding and the length of hospitalization

Conditions: Feeding; Difficult, Newborn

Summary: feeding is one of the most common problems encountered by preterm infants. besides, effective and safe feeding is one of the important discharge criteria. feeding problems of premature infants lead to prolonged hospitalization and increased healthcare cost. sinc feeding protocol was developed based on evidence-based feeding protocol (such as cue-based, infant-driven feeding) and individualized developmental care. the aim of the study is to determine the effect of the sinc feeding protocol on weight gain, transition to oral feeding and the length of hospitalization in premature infants according to traditional feeding method. randomized controlled study, including 30 infants of 28-33+6 weeks gestation receiving either standard feeding or sinc feeding protocol.


Eligibility criteria:
inclusion criteria: having been born between 24-33+6 weeks of gestational age 28-33+6 postmenstrual weeks monitoring with the diagnosis of healthy preterm infants exclusion criteria: * receiving mechanical ventilation * congenital anomalies * having a surgical operation * having serious health problems

Keywords: premature infants sinc feeding protocol
efficacy of combination therapy with minocycline for treatment of stenotrophomonas maltophilia infections

Conditions: Hospital Infections

Summary: the objective of the study is to evaluate the efficacy of minocycline for treatment stenotrophomonas maltophilia infection. the hypothesis of study is the combination therapy with minocycline would be better than the monotherapy for treatment stenotrophomonas maltophilia infection.

* investigator inform patient or their relatives about all topics in project, eligible criteria, method, material and monitoring treatment. * after patient or their relatives are appreciated to join this project, patients will be randomly allocated to either levofloxacin or cotrimoxazole plus placebo (monotherapy plus placebo) or levofloxacin or cotrimoxazole plus minocycline (combination therapy). * duration of treatment is determined by site and severity of infection, approximately 7-28 days. * sample size calculation, by two independent proportions formula, the investigators estimate the mortality rate about 54 % in monotherapy group and mortality rate about 27 % in combination therapy with minocycline group, with 2-sided 95% confidence interval; therefore,51 persons are needed each group. * the investigators estimate gather data about 112 persons. (56 participants with monotherapy and 56 participants with combination therapy (minocycline plus another antibiotic drug from intervention trial)) * the categorical variables are reported as frequencies and percentages, while continuous variables are reported as means ± standard deviations for normally distributed data and median ± range for non-normally distributed data. the data collected from patients are compared using chi-square tests or fisher's exact tests for categorical variables and using t-tests or mann-whitney u-tests for continuous variables. * during the study is performing, all unexpected adverse event definitely report to siriraj institutional review board immediately, in addition to subjects or their relatives.

Eligibility criteria:
inclusion criteria: * the infection caused by stenotrophomonas maltophilia * the duration of treatment approximately between 7-28 days * the patients can take minocycline capsule via oral or nasogastric tube feeding. * the patients are anticipated to live more than 48 hrs after participation. * in case of an antibiotic drug administration for treatment stenotrophomonas maltophilia beforehand, it should not exceed 48 hrs. * all of participants should be willing to join this project. exclusion criteria: * pregnancy and lactation * the patients with active hepatitis * the patients with history of minocycline allergy

Keywords: minocycline stenotrophomonas maltophilia
prevalence and risk factors nocturnal polyuria in female oab

Conditions: Nocturia

Summary: nocturnal polyuria may decrease the treatment efficacy of overactive bladder syndrome (oab); and adjuvant medication, such as desmopressin, may be needed for the treatment of nocturnal polyuria. the knowledge of prevalence and risk factors of nocturnal polyuria might be important for the treatment of oab. thus, our aim is to describe the prevalence and risk factors of nocturnal polyuria in women with oab.

between july 2009 and january 2018, all women with oab visiting a medical center for evaluation were reviewed. the classification of oab-wet or oab-dry is based on the record of the three-day bladder diary of each patient. the diagnosis of oab in each patient was based on the presence of at least one episode of urgency in her three-day bladder diary and with the absence of stress urinary incontinence. the presence of at least one episode of urgency associated incontinence was defined to be oab-wet, otherwise, oab-dry. nocturnal polyuria was defined when the proportion of nighttime voided volume over 24-hour voided volume was greater than 33% for ≥65-year-old women, and when the proportion of nighttime voided volume over 24-hour voided volume was greater than 20% for \<65-year-old women.

Eligibility criteria:
inclusion criteria: 1. more than 20-year-old 2. female 3. diagnosed with overactive bladder exclusion criteria: 1. younger than 20-year-old 2. pregnant or planned to be pregnant

Keywords: nocturnal polyuria overactive bladder
the use of incentive spirometry in adult patients hospitalised in a rehabilitation center with long-covid syndrome

Conditions: Long COVID

Summary: the aim of this clinical trial is to investigate the efficacy of triflow in the rehabilitation of patients with long covid syndrome hospitalised in a rehabilitation center. participants will be divided into 2 groups and follow their exercise regime until the day they are discharged from the rehabilitation center. the intervention group will participate in a rehabilitation program which includes upper and lower limbs exercises, cycle ergometer, walking and the use of triflow. the control group will participate in the same program but without the triflow.

randomised controlled trial with 2 groups:triflow and exercises (intervention) and exercises (control) exercises:exercises in the bed, chair and standing with/without weights, walking, cycle ergometer, treadmill. triflow: 10 breaths in and 10 breaths out. both groups will have 1 physiotherapy session per day for 6 days per week from admission to discharge. sample size:the sample size is 70. we took into consideration the efficacy of completing the recruitment of patients in time. there few published studies with the use of triflow as their primary intervention with smaller sample sizes. population: adults with long covid hospitalised in the rehabilitation center statistical analysis: will be done through ibm spss statistics 20 and the level of statistical significance will be (p \< 0.05). from the literature and international guidelines, physiotherapy should be offered to people hospitalized with long-covid, without any serious risks and offering significant benefit.

Eligibility criteria:
inclusion criteria: * adults who were infected with covid-19 in the last 6 months and were diagnosed with long-covid syndrome * patients must be willing to give written consent for participation in the study * negative rapid test for covid-19 exclusion criteria: * history of diseases that do not allow exercise (e.g. unstable cardiac disease) * age \< 18 years of age * significant cognitive and psychiatric impairments (inability to follow simple commands or give consent) * lack of will to do the exercises or refuse to give consent

Keywords: triflow, incentive spirometry, long-covid
pilot trial of urinary nerve growth factor (ngf) as biomarker for male lower urinary tract symptoms

Conditions: Lower Urinary Tract Symptoms

Summary: a single center, pilot trial using tamsulosin and solifenacin in 10 men with symptomatic lower urinary tract symptoms (luts). subjects will be evaluated at baseline, 1, 2, and 3 months for urinary ngf, urine creatinine, ngf/cr ratio and patient reported outcomes through questionnaires.

single center, pilot trial, single arm study using once daily dosing of tamsulosin and solifenacin in 10 men with symptomatic lower urinary tract symptoms (luts). assessments occur at baseline, 1 month, 2 month and 3 month to evaluate: urinary ngf (pg/ml), urine creatinine (mg/dl), ngf/cr ratio and patient reported questionnaire outcomes (aua symptom score/ipss, patient perception of bladder condition, patient perception of urge intensity 'ppius', luts urinary symptoms and quality of life). each participant is assessed from baseline to month 3 measurements. protection of human subjects will be provided through the houston methodist research institute institutional review board (see appendix 2). all men will receive morning dosing with tamsulosin 0.4 mg (1 tab) and solifenacin 5 mg (1 tab) orally at the same time.

Eligibility criteria:
inclusion criteria: * men \> 45 years old with symptomatic luts (clinical benign prostatic hypertrophy/bph) * international prostate symptom score (ipss) \> 8 * psa \< 10 ng/ml (negative biopsies within 6 months for any age-specific psa elevation suspicious for prostate carcinoma) * post void residual urine \< 150 mls * urinary flow rate \> 15 ml/sec exclusion criteria: * neurogenic bladder * urinary tract infection, urinary stone(s), urinary tract tumor * radiation therapy for urologic malignancy or prostate surgery; radiation to pelvic, colon, rectum, prostate, bladder, uterus or ovaries * alpha blocker therapy or anticholinergic therapy within 3 months of entry or 5 alpha reductase therapy within 18 months. * history of cataracts with planned surgery
does antibiotic prophylaxis at urinary catheter removal prevent urinary tract infections

Conditions: Urologic Diseases; Urinary Tract Disease

Summary: at the end of most urological procedures, the doctor inserts a urethral catheter for a period of up to 5 days. according to aua's guidelines, prophylactic antibiotic is indicated during catheter removal. the aim of our study is to check the influence of the antibiotic treatment on urinary tract infections after catheter removal


Eligibility criteria:
inclusion criteria: * performing urological operation for other reason exclusion criteria: * cannot give informed consent * \<18 years
safety and efficacy study of adalimumab in the treatment of plaque psoriasis

Conditions: Plaque Psoriasis

Summary: a study to evaluate the safety and efficacy of adalimumab in chinese subjects with moderate to severe plaque psoriasis.

the purpose of this study is to evaluate the safety and efficacy of adalimumab and to determine how well it works in the treatment of adults with moderate to severe plaque psoriasis in the chinese population. psoriasis is a chronic immunologic disease characterized by marked inflammation and thickening of the epidermis that result in thick, scaly plaques involving the skin.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of psoriasis for at least 6 months. * must have stable plaque psoriasis for at least 2 months before screening and baseline visits. * participant must have a psoriasis area severity index score greater than or equal to 10 at the baseline visit. * participant must have moderate to severe plaque psoriasis, defined by body surface area involvement greater than or equal to 10% at the baseline visit. * participant must have a physicians global assessment of at least moderate disease at baseline visit. exclusion criteria: * diagnosis of other active skin diseases or skin infections. * participant has known hypersensitivity to adalimumab or it excipients. * participant has chronic recurring infections or active tuberculosis. * participant has demyelinating disease (including myelitis) or neurologic symptoms suggestive of demyelinating disease. * participant is known to have immune deficiency or is immunocompromised.

Keywords: plaque psoriasis psoriasis placebo controlled skin disease double blind
heart risk 6 scale in emergency department acute heart failure patients

Conditions: Acute Heart Failure (AHF)

Summary: detect the predictive value of the heartrisk6 scale in predicting short-term serious outcomes in emergency department acute heart failure patients in egyptian population

recently, the heartrisk6 scale was introduced to predict the short-term serious outcomes in emergency department acute heart failure patients. it was created from 3 cohorts from american and canadian population. since the egyptian population differ from the american and canadian population regarding the age at presentation with cardiovascular disease, risk factors and etiology of the acute heart failure, we sought to detect the applicability of this score on our population.

Eligibility criteria:
inclusion criteria: * patients who have appropriate symptoms (short-ness of breath or fatigue)(\<7 days duration); with clinical signs of ﬂuid retention (pulmonary or peripheral) in the presence of an underlying abnormality of cardiac structure or function. * if in doubt, a beneﬁcial response to treatment (eg, a brisk diuresis accompanied by improvement in breathlessness) will be considered. exclusion criteria: * patients who did not ﬁt the deﬁnition of ahf or who were clearly too ill to be considered for discharge after 24 hours from ed: * 1) resting oxygen saturation \<85% on room air * 2) heart rate \>120 beats/min; * 3) systolic blood pressure \<85 mm hg; * 4) confusion, disorientation, dementia; * 5) primary presentation for ischemic chest pain requiring treatment or with acute ischemic st-tchanges on initial electrocardiogram (ecg);

Keywords: heart risk 6 scale acute heart failure
jardiance® post marketing surveillance in korean patients with chronic kidney disease (ckd)

Conditions: Kidney Disease, Chronic

Summary: the primary objective is to monitor the safety profile of jardiance® in korean patient with chronic kidney disease (ckd) in routine clinical practice. the secondary objective is to monitor the efficacy of jardiance® by evaluating changes in urine albumin-creatinine ratio (uacr) after 12 and/or 24 weeks of treatment.


Eligibility criteria:
inclusion criteria: * age ≧19 years at enrolment * patients diagnosed with ckd * patients with ckd starting jardiance® for the first time in accordance with the approved label in korea * patients who have provided informed consent and signed the data release consent form exclusion criteria: * patients with previous exposure to jardiance® * patients with hypersensitivity to empagliflozin or to any of the excipients * patients with type 1 diabetes * patients with history of diabetic ketoacidosis (dka) * patients with rare hereditary conditions of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption * patients who are pregnant or are breastfeeding or who plan to become pregnant during the study period