Kornimate/medical-research-clean huggingface dataset:
microwave coagulation in partial nephrectomy protocol

Conditions: Cancer of Kidney

Summary: partial nephrectomy (kidney removal) is a standard therapy for clinical t1 renal (kidney) tumors. the goals of surgery are to accurately remove the tumor with no cancer cells at the edge of the remaining tissue, to limit blood loss, and preserve kidney function. the most common technique is to clamp the blood supply to the entire kidney during removal and to surgically repair the tumor bed with suture and agents to stop bleeding. this stops the blood supply to the entire kidney including the healthy tissue, which can cause damage to the remaining tissue due to a shortage of oxygen if left clamped too long. this study uses a microwave pre-coagulation technique using the certus 140™ to facilitate a bloodless area near the tumor for accurate tumor removal and repair, while avoiding clamping the blood supply, but its effect on the function of kidney adjacent to tumor is unknown. if adequate stoppage of bleeding is achieved using the certus 140™ with minimal heat spreading to the remaining tissue, clamping and a shortage of oxygen can be avoided. the hypothesis is that microwave pre-coagulation is a safe method for providing the stoppage of bleeding during partial kidney removal.


Eligibility criteria:
inclusion criteria: 1. patient must have a solitary, polar, clinical t1 renal mass 2. patient must have adequate kidney function as measured by egfr (estimated glomerular filtration rate) greater than or equal to 50 calculated from a standard care serum creatinine performed within 30 days prior to the partial nephrectomy operation. 3. women of child-bearing potential must have negative serum or urine pregnancy test 4. patient must be able to give written informed consent 5. patient must be 18 years or older 6. no blood-thinning medications, including anti-inflammatory medications, herbs and supplements for at least 1 week prior to surgery exclusion criteria: 1. t stage greater than clinical t1 2. tumor extends beyond kidney into major veins, perinephric tissues, or adrenal gland 3. prior surgery or radiation therapy to the region of interest 4. patient has a single functioning kidney 5. patient has an uncorrectable coagulopathy 6. patient is not a surgical candidate due to underlying cardiac or other serious comorbid condition

Keywords: cancer of the kidney renal cancer renal neoplasms neoplasms, kidney
the efficacy of exercise therapy in patients with inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases; Sarcopenia

Summary: this study aims to determine the effect of 8 weeks of exercise on the quality of life and muscle strength of patients with ibd. patients will be randomized into 1) intervention group: doing aerobic and resistance exercise according to physiotherapist prescription and 2) control group: usual medical care. both groups will continue their medications prescribed by the gastroenterologist. after 8 weeks patients come back to the hospital for reevaluation of measured indices. the primary outcome of this study is the patient quality of life assessed by the ibdq questionnaire. other outcomes that will be evaluated before and after 8 weeks are muscle strength measured by a dynamometer and laboratory markers such as esr and crp and tool calprotectin. also, disease activity using partial mayo score and harvey bradshaw score will be calculated and compared before and after treatment.

inflammatory bowel disease has a huge burden both on patients and on the health system due to its chronic nature. studies have shown a higher prevalence of sarcopenia, a condition in which muscle mass and strength decreases, in patients with ibd compared to age and sex-matched healthy individuals. patients with ibd are physically less active than the normal population according to a couple of researches. there has been a growing interest to evaluate the effect of exercise on the quality of life and disease severity of ibd patients in recent years. this study aims to determine the effectiveness of combined aerobic and resistance exercise on quality of life, physical function, muscle strength, disease activity, and laboratory markers in patients with established ibd. the researchers will invite 56 patients to the imam khomeini hospital complex, tehran, iran. all patients will be enrolled after taking informed consent. interventions will be conducted with the coordination of the patient's physician. patients will be randomized to the intervention or control group. outcome measurements will be evaluated immediately before and after the interventions (8 weeks period)

Eligibility criteria:
inclusion criteria: 1. patients with ibd (uc or chron's) confirmed by colonoscopy and pathology 2. be able to read and write in farsi 3. be able to participate to exercise therapy program. exclusion criteria: 1. patients with psc 2. patients with cirrhosis 3. patients with colon cancer 4. patients on corticosteroid treatment 5. patients' dissatisfaction to continue the study for any reason 6. patients who exercise on a daily routine (more than 30 minutes per day) 7. patients having any contraindication for exercise training.

Keywords: inflammatory bowel disease aerobic exercise resistance exercise sarcopenia quality of life
measuring quality in colorectal cancer surgery in low- and middle-income countries

Conditions: Colorectal Cancer; Postoperative Complications; Surgical Complication; Non-communicable Disease

Summary: to test the applicability of the clavien-dindo classification (cdc) in an lmic setting and to compare the prevalence and severity of complications in patients \<60 and ≥60 years of age a retrospective medical records review is used.

background: colorectal cancer (crc) is increasing in low- and middle-income countries (lmic) as part of the ongoing epidemiological transition. surgery is the main treatment and the global health agenda is increasingly putting focus on improving the safety and quality of surgical care in low-resource settings. the current systems for measuring surgical quality are mainly customized for high-income countries. aim: to test the applicability of the clavien-dindo classification (cdc) in an lmic setting. additionally, to compare the prevalence and severity of complications in patients \<60 and ≥60 years of age. material and methods: retrospective medical records review for postoperative complications and severity grading using the cdc.

Eligibility criteria:
inclusion criteria: * patients who has gone through colorectal cancer resection. * surgery performed at colombo south teaching hospital in colombo, sri lanka. exclusion criteria: * reason for resection other than colorectal cancer.

Keywords: colorectal cancer sri lanka clavien-dindo classification postoperative complications surgical quality
effect of a commercial cosmetic mouth rinse on plaque re-growth

Conditions: Healthy Subjects

Summary: a clinical study to evaluate the effect of a commercial mouth rinse on plaque re-growth


Eligibility criteria:
inclusion criteria: * good general and oral health * at least 20 natural gradable teeth * mean plaque score (turesky modification of the quigley hein index) of greater than or equal to 2.00 at the first baseline visit

Keywords: tooth plaque
prospective clinical observational cohort study to evaluate the use of a tissue separating mesh (proceed®) in laparoscopic ventral hernia repair

Conditions: Ventral Hernia

Summary: 1. general: antibiotic prophylaxis: cefazoline (cefacidal™) 2 gram iv administered 30 minutes before surgery 2. laparoscopic surgery * at least 5 cm overlap (mesh diameter should exceed hernia size by at least 10 cm) * with or without anchoring transparietal sutures or double crown technique


Eligibility criteria:
inclusion criteria: * written informed consent from the patient or his/her legal representative * ventral hernia requiring elective surgical repair exclusion criteria: * no written informed consent * 'hostile' abdomen; open abdomen treatment * contraindication to pneumoperitoneum * emergency surgery (incarcerated hernia) * parastomal hernia
usefulness of chromoendoscopy for the early detection of colorectal cancer associated with inflammatory bowel disease

Conditions: Inflammatory Bowel Disease; Colorectal Cancer

Summary: to assess the feasibility and effectiveness of a program in l-ibd patients using ce targeted biopsies

we aim to know the prevalence and incidence of dysplasia and colitis-associated colorectal cancer in patients with longstanding colonic inflammatory bowel disease (n-ibd), in spain and the usefulness of advanced endoscopy (chromoendoscopy) for the diagnosis and endoscopic differential diagnosis of n-ibd.

Eligibility criteria:
inclusion criteria: * diagnosis of uc or colitis ec corroborated by clinical and histology * involvement of at least one third of the colon in patients with cd * involvement proximal to the rectum in patients with uc * duration of disease \> 10 years * no clinical activity: * may score \<6 * cdeis \<3.5 exclusion criteria: * personal history of crc * colectomy * coagulopathy * refusal to participate in the study * known allergy to indigo carmine * colonoscopy in the last 6 months

Keywords: chromoendoscopy ulcerative colitis crohn disease colorectal neoplasia
exposure and response prevention with behavioral- versus cognitive therapy rationale in obsessive compulsive disorder

Conditions: Obsessive-Compulsive Disorder

Summary: the aim of the study is to determine whether exposure and response prevention (erp) is more effective when patients are presented with a behavioral therapy versus cognitive therapy rationale in the treatment of obsessive-compulsive disorder (ocd).

the aim of the study is to determine whether exposure and response prevention (erp) is more effective when patients are presented with a behavioral therapy versus cognitive therapy rationale in the treatment of obsessive-compulsive disorder ocd. a randomized controlled trial including patients with ocd. 50 patients will receive 15 erp sessions in 3 months.

Eligibility criteria:
inclusion criteria: * obsessive-compulsive disorder exclusion criteria: * active thought disorder, uncontrolled bipolar disorder, mental retardation, organic mental disorder, initiation or change in medication three months prior to inclusion in the study
acupuncture for female with non-cyclic chronic pelvic pain

Conditions: Chronic Pelvic Pain

Summary: chronic pelvic pain (cpp) is one of the common symptoms of women at childbearing age. the aim of this study is to assess the efficacy of acupuncture for female with non-cyclic chronic pelvic pain. a three-arm randomized controlled trial (rct) using acupuncture, sham acupuncture and waiting list with a total sample of 150 will be conducted.

chronic pelvic pain (cpp) is a persistent pain in pelvis, anterior abdominal wall, lower back, or buttocks lasting at least six months. according to a who epidemiological study, the worldwide prevalence rate of cpp in childbearing age women was 2.1%-24%. at present, nearly 55% of the patients had unclear etiology, and there is no universally accepted diagnosis, evaluation and treatment. cpp is often associated with gynecological and non gynecological diseases, including endometriosis, abdominal visceral adhesion, myofascial pain and dysfunction, irritable bowel syndrome and interstitial cystitis/bladder pain syndrome. cpp are also accompanied by psychological and physiological dysfunction, the most common is depression and anxiety, which seriously affects the quality of life of patients. acupuncture may have effect on non-cyclic cpp in female, however, there is a lack of evidence of effectiveness of acupuncture. a multi-center randomized three-armed controlled trial will be conducted. the aim of this study is assess the efficacy and safety of acupuncture for female patients with non-cyclic cpp.

Eligibility criteria:
inclusion criteria: * meet the diagnostic criteria of non-cyclic cpp. * age 18 to 50 years. * have moderate to severe pain in pelvis, anterior abdominal wall, lower back, or buttocks lasting at least six months. * the mean degree of pelvic pain in the past week rated by visual analogue scale is ≥40 scores. * sign informed consent and participate in the study voluntarily. exclusion criteria: * have endometriosis (including adenomyosis), ovarian cyst (larger than 3cm), hysteromyoma (larger than 3cm), severe pelvic adhesion, pelvic malignant tumor (relevant examination must be within the last 6 months). * have acute pelvic/urinary tract infection. * have pain after pelvic surgery. * have recurrent gastrointestinal or bladder diseases such as irritable bowel syndrome, interstitial cystitis / bladder pain syndrome, etc. * during pregnancy or in lactation or have a pregnancy plan within 8 months. * have heart, lung, liver, kidney, mental disorders or cognitive dysfunction. * have acupuncture treatment in recent 3 months.

Keywords: acupuncture sham acupuncture randomized controlled trial non-cyclic chronic pelvic pain
efficacy of photobiomodulation on wound healing and il-6 in neuropathic foot ulcer

Conditions: Neuropathic Foot Ulcer

Summary: the aim of this study is to detect the effect of laser photobiomodualation on the wound healing and il-6 in neuropathic foot ulcer.

wound healing is a complex, interactive, and integrative event, involving cellular and chemotactic activity with release of chemical mediators associated with vascular responses and cell proliferation. it consists in a sequence of events leading to the closure of dermal injuries. the repair follows steps of inflammation, re-epithelization, wound contraction, and matrix remodeling. the healing process can be influenced by various local and systemic factors. the ulcer treatment in the diabetic foot requires a multidisciplinary approach, including revascularization and surgical procedures, as well as the infection treatment, physiotherapeutic rehabilitation with electric phototherapeutic resources to control edema, pain, metabolic disorders, tissue malnutrition, co morbidities, precise treatment of the wound and biomechanics' decompression that will help in amputation prevention. biophotomodulation in the form of low level laser (lll) irradiation can promote cell migration and cell proliferation by stimulating mitochondrial activity and maintaining viability without causing damage to the wounded cells. the usage of lllt presents itself as being a new therapeutic proposal, seeking the cure of these injuries, the improvement on the quality of life of the affected individuals, as well as the reduction of the costs of the treatment in the health system, this study aims to identify the effects of low-level laser therapy on neuropathic foot ulcer healing and the effect of lll on the hyperglycemic-induced inflammatory response in il-6 and sought to identify which pathway it might achieve this effect.

Eligibility criteria:
inclusion criteria: * all patient will be diagnosed with neuropathic foot ulcer. * all patient diagnosed as type ii diabetes mellitus. * wound size a 6-12 cm2. * diabetic ulcers will be in grade 2 and 3 (partial thickness skin loss involving epidermis and or dermis (superficial, abrasion, blister, and / or full thickness skin loss damage ore necrosis of subcutaneous tissue may extend down to but not through underlying fascia. exclusion criteria: * presence of osteomyelitis. * patients associated with critical illness who needs intensive care. * patients who suffer from cellulitis. * patients who suffer from nerve injury. * pregnancy. * smokers * malignant diseases * use of immunosuppressive drugs * phenytoin, cyclosporine, calcium channel blockers, etc. * patients who not have burn or ulcer or trauma in this area
potential benefits of black seed oil supplementation on asthma inflammation and outcomes

Conditions: Asthma

Summary: traditionally, black seed (nigella sativa) is a well-known food supplement and herbal product that has a wide range of medical claims (including asthma) that originate from different historical backgrounds. today in the era of evidence-based medicine, it is hard to accept those traditional medical claims of medicinal plants without valid scientific experiments. thus, randomized clinical trials is important to rational the uses of herbal products. asthma is a common chronic disorder of the airways, characterized by variable reversible and recurring symptoms related to airflow obstruction, bronchial hyper-responsiveness, and underlying inflammation. in saudi arabia, asthma is considered one of the leading chronic diseases affecting more than 2 million saudi citizens. the global asthma report 2014 considered asthma as an epidemic disease probably affecting about 334 million people worldwide and becoming a global health priority. this project investigates the use of herbal products to enhance asthma control in saudi arabia. in this context, black seed is one of the common herbal products used traditionally for asthma in the saudi region. black seed is a common unconventional therapy used among 10% of asthmatic patients in king abdulaziz medical city, riyadh. in fact, there are some pre-clinical evidence and preliminary clinical studies support the usefulness of black seed in asthma and its underlying causes


Eligibility criteria:
inclusion criteria: * adult male/female (age 18-65 years), * asthmatic patient with asthma control test (act) score \<25 * no severe asthma exacerbation in the last 4 weeks * able to obtain consent exclusion criteria: * patients with serious co-morbid conditions such as; cancer, renal, hepatic, cardio-vascular, gastrointestinal diseases, mental health conditions and respiratory disorder such as tb and copd. * smoking history * pregnant women * currently taking any form of black seed. * known history of hypersensitivity to black seed. * taking medications that may interact with black seed supplement: anticoagulant/antiplatelet, cns depressants, and immunosuppressant drugs

Keywords: asthma black seed nigella sativa supplementation
enhancement of brown adipose tissue function via chronic pharmacological treatment

Conditions: Type 2 Diabetes; Obesity; Cardiovascular Disease

Summary: obesity is epidemic in australia, and current preventative strategies have had limited success in alleviating this health crisis. while numerous options are available for treatment of obesity, most do not result in sustained weight reduction. obesity results from an imbalance between energy intake and expenditure, therefore new methods that correct this imbalance are essential for effective long-term treatment. rodent studies show that brown adipose tissue (bat) can burn more energy than any other tissue in the body, therefore targeting bat to increase its activity (energy burning rate) and quantity in humans is potentially a powerful tool for the treatment of obesity and related diseases. bat has only recently been irrefutably identified in adult humans therefore little is known about how it functions in humans.


Eligibility criteria:
inclusion criteria: * males aged 19 - 35 years * free of overt coronary disease (on history, medical examination and ecg) * unmedicated * no major illness * bmi \<27 kg/m2 exclusion criteria: * unable to give informed consent * smokers * participant in research projects involving ionising radiation within the past 5 years. * claustrophobia * fasting plasma glucose \> 6.0 mmol/l
screening for pulmonary vascular changes in patients with chronic myeloproliferative diseases

Conditions: Myeloproliferative Disorders; Pulmonary Hypertension

Summary: goal of the study is to assess the frequency of pulmonary hypertension in patients with chronic myeloproliferative diseases. in each patient an echocardiography at rest will be performed. in patients without musculoskeletal disease an exercise test (spiroergometry) will be performed. patients with elevated spap at rest or with reduced exercise capacity (peak vo2 \< 65%) a right heart catheterization (rhc) will be recommended. also patients with advanced nyha functional class (iii or iv) or with typical ph findings in electrocardiogram will be advised to undergo a rhc. additionally for the evaluation of exercise capacity a 6 mwd will be performed. this work- up of patients allows clinical and hemodynamic evaluation.

previous small studies and clinical cases have suggested a possible association between pulmonary hypertension (ph) and chronic myeloproliferative disorders (cmpd). mpd may cause ph through different mechanisms as: high cardiac output, asplenia, direct obstruction of pulmonary arteries by megakaryocytes, chronic thromboembolic endothelial pulmonary hypertension (cteph), porto-pulmonary hypertension (poph). however, the exact prevalence of ph in this group of disorders is not known. this study is designed to identify the pulmonary vascular changes and describe the prevalence of pulmonary hypertension (defined in this study as mean pulmonary arterial hypertension (mpap) ≥25mmhg as assessed by right-heart catheterization (rhc) or systolic pulmonary arterial pressure (spap) ≥37mmhg (2.9 m/s) assessed by echocardiography.

Eligibility criteria:
inclusion criteria: * patients with myeloproliferative disorders * written informed consent exclusion criteria: * manifest pulmonary hypertension * significant pulmonary disease * left-sided heart failure or diastolic compliance dysfunction * hemodynamic relevant valvular disease * systemic arterial hypertension (at rest systolic \>150 mmhg, diastolic \> 90 mmhg, during exercise \> 220 mmhg) * severe anemia * uncontrolled supraventricular and ventricular arrhythmias * myocardial infarction (within the last 12 months) * pulmonary embolism (within the last 12 months) * recent therapy changes (within the last 12 months) * recent major surgeries (within the last 12 months) * for exercise tests: musculoskeletal diseases which may unable the exercise tests

Keywords: myeloproliferative disorders pulmonary hypertension pulmonary vascular diseases