Kornimate/medical-research-clean huggingface dataset:
a study comparison of clinical outcome after different rate of infusion in caudal epidural steroid injection

Conditions: Spinal Stenosis; Lumbosacral Spondylosis; Radiculopathy

Summary: the purpose of this study is to determine the effects of different rates of caudal epidural steroid injection (cesi) on clinical outcomes of the patients.


Eligibility criteria:
inclusion criteria: * lumbosacral spinal stenosis with radiculopathy * no improvement after conservative treatment for 6 weeks exclusion criteria: * previous cesi or spinal surgery * skin infection at injection site * uncontrolled diabetes mellitus * abnormal coagulogram * vertebral fracture * previous history of allergy to steroid or anesthetic agent
evaluation of marital and sexual satisfaction of wives to erectile dysfunction males

Conditions: Erectile Dysfunction

Summary: erectile dysfunction (ed), previously known as sexual impotence, is defined as the persistent inability to obtain and/or maintain a penile erection that is hard enough for satisfactory sexual intercourse. the number of reported patients with ed is increasing and it is becoming a real medical problem.

marital satisfaction is a global evaluation of the state of one's marriage or current long-term romantic relationship. this global evaluation can be a reflection of a how happy people are in their marriage in general or a composite of satisfaction with several specific facets of the marital relationship. sexual health can be described as enjoying and fulfilling sexual desires without harming, physical or psychological, oneself or others. sexual functioning is an important part of a patient's health and well-being. patients often seek for treatment late due to embarrassment and commonly with an alternative problem. sexual and erectile functions are considered important components of men's overall health. the psychosocial impact of ed can lead to depression, loss of self-esteem, and relationship and marital difficulties. personality is defined as the "distinctive and characteristic patterns of thought, emotion and behavior that define an individual's personal style and influence his or her interaction with the environment".

Eligibility criteria:
inclusion criteria: * married couples exclusion criteria: * unmarried couples.
a multi-site study to evaluate the safety and effect of study drug on participants with rheumatoid arthritis

Conditions: Arthritis, Rheumatoid

Summary: this study is a multicenter, double-blind, study to evaluate the safety and effectiveness of treatment with ly2127399 (in addition to the standard of care treatment, methotrexate) for participants with rheumatoid arthritis. participants will receive three intravenous doses of ly2127399 or placebo. participants will participate in 10 or more visits to the study site, over 6 months. evaluation of safety and efficacy will be conducted throughout the study.


Eligibility criteria:
inclusion criteria: * male or female between the ages of 18 and 75 years * have given written informed consent approval * women must not be at risk to become pregnant during study participation * diagnosis of rheumatoid arthritis according to the 1987 revised american rheumatism association (ara) criteria for the classification of ra * serum c-reactive protein (crp) measurement greater than the upper limit of normal (uln, 0.574 mg/dl), or erythrocyte sedimentation rate (esr) ≥28 mm/hr * current, regular use of methotrexate, at a stable dose * biologic dmard naïve, and have had an insufficient response (in the opinion of the investigator) to an adequate therapeutic dose of at least 1 oral dmard exclusion criteria: * use of excluded medications (reviewed by study doctor) * surgical treatment of a joint with 2 months of study enrollment that is to be assessed in the study * are unable to ambulate; that is, confined to bed or wheelchair bound * have medical findings which, in the opinion of the study doctor, put participant at an unacceptable risk for participation in the study * have had recent or ongoing infection which, in the opinion of the study doctor put participant at an unacceptable risk for participation.
a mindful self-compassion based intervention for specialist rehabilitation providers

Conditions: Burnout, Professional; Compassion Fatigue; Secondary Traumatic Stress

Summary: the goal of this clinical trial is to explore the impact of an online compassion-based intervention on burnout among specialist rehabilitation providers. post-intervention interviews aim to gather information on: burnout and compassion, experiences with the intervention, barriers and facilitators to taking part, and suggestions for improving online course delivery.

burnout threatens the sustainability of compassionate care in rehabilitation. this project explores the impact of an online compassion-based intervention on burnout among specialist inpatient rehabilitation healthcare providers. thirty specialist rehabilitation healthcare providers will be recruited to take part. the online intervention will include six weekly live one-hour sessions. healthcare provider socio-demographic, practice, and wellness measures will be collected at baseline, post-course, and three months later. qualitative interviews will be used to explore participant views on burnout and compassion, experiences with the intervention, barriers and facilitators to taking part, and suggestions for improving online course delivery. up to two instructors and support persons will be invited to participate in qualitative interviews to explore their views for improving online course delivery.

Eligibility criteria:
inclusion criteria: * employed substantively as a regulated health professional (e.g., physiatrist, nurse, allied health professional) by a specialist rehabilitation institute (e.g., sunnybrook/st. john's rehab, university hospital network, providence healthcare, westpark healthcare) * over 18 years of age * able to speak, read, and write in english * willing to take part in the msc course for up to the full 6-week duration * willing to complete all study related questionnaires exclusion criteria: * those already having completed a msc (mindfulness-based stress reduction) course or mindfulness-based cognitive therapy within the past 12 months * those employed as agency staff

Keywords: mindful self-compassion compassion-based intervention meditation online intervention rehabilitation providers physiatrists
the resting insomnia study: randomized controlled study on effectiveness of stepped-care sleep therapy

Conditions: Insomnia

Summary: this project aims to compare the effectiveness and implementation potential of two primary care friendly approaches to delivering an effective non-pharmacological intervention - cognitive behavioral therapy - for insomnia to middle aged and older adults.

all participants will receive cognitive behavioral therapy for insomnia, either through an online program or through visit with a therapist specializing in behavioral sleep medicine, and is some cases both. participants will be randomized with equal probability to an online only treatment arm or to a stepped care arm, whereby they will be assigned to on line or therapist-led treatment, based on their clinical presentation; but those assigned to this arm who start treatment with an online program and do not have sufficient response after 2 months will be switched over to a therapist-led treatment.

Eligibility criteria:
inclusion criteria: * insomnia disorder exclusion criteria: * unable to be consented in english without an interpreter * in poor physical or mental that limits capacity to participate in study treatment (e.g., mini-mental state examination score \< 25) * unable to use the internet * study physician determines participation is not medically advised for any reason
use of repris needle in bladder injection

Conditions: Overactive Bladder Syndrome

Summary: treatment of overactive bladder (oab) has been treated successfully by the injection of botox. the repris injection needle has a deflection that may assist in injection difficult to reach with standard straight needles. this study will assess the success, safety and patient tolerance of this new injection needle.

this is a prospective, multicenter, single arm study of the repris injection needle to administer botox to the bladder wall in patients with an overactive bladder. following advancement of a cystoscope to the patient's bladder, the repris needle will be advanced to the area of interest and into the bladder wall in order to administer the recommended volume of botox. after injection, the needle will be removed and the procedure will be concluded. the patient will be asked to rank her tolerance of the procedure and level of discomfort using a standardized pain scale before being released. five days after the procedure the patient will be contacted by telephone to determine whether any adverse events had occurred since release.

Eligibility criteria:
inclusion criteria: * adult (18 years of age or older) * able to undergo routine cystoscopy * willing to provide verbal assessment of her condition within 5 days after the procedure exclusion criteria: * history of urethral strictures * presence of a suprapubic catheter or tube due to urethral trauma * history of interstitial cystitis * currently being treated for a urinary tract infection (uti) * gross hematuria present * known allergy or sensitivity to any component of the medication or solution to be injected during the study * is pregnant, lactating, or with child-bearing potential unable or unwilling to use a reliable form of contraception while participating in the study * cannot empty her bladder on her own and is routinely catheterizing the urethra * unable to read, understand, and/or provide a ranking of pain level during the procedure, * unable or unwilling to provide consent
behavioural activation-based treatment administered through smartphone

Conditions: Depression

Summary: the objective is to test the effects of a smartphone-delivered behavioural activation treatment. also, a moderator analysis of low and high severity of depressive symptoms will be made. we expect the behavioural activation intervention to be superior to the mindfulness intervention for the participants suffering from high severity of depressive symptoms - and the mindfulness intervention to be better or at least as good as the behavioural activation intervention for the participants suffering from low severity of depressive symptoms.

major depression is expected to be the disorder with the highest disease burden in high-income countries by the year 2030. the efficacy of behavioural activation in the treatment of major depressive disorders has been established in a number of studies over the last four decades. furthermore, behavioural activation is an intervention that can largely benefit from the use of new mobile technologies (e.g. smartphones). one important feature of mobile technology is the possibility for the therapist to reach the patient between sessions and thus create direct incentives for behavioural activation in everyday life. therefore, developing smartphone-based behavioural activation interventions might be a way to develop a cost-effective treatment for people suffering from major depressive disorders.

Eligibility criteria:
inclusion criteria: * depressive symptoms according to dsm-iv * have access to the internet and a smartphone * have good knowledge of the swedish language exclusion criteria: * recent (during last 6 weeks) change in psychiatric medication * presently in any other psychological treatment * severe depression * suicidal ideation

Keywords: depression smartphone behavioural activation mindfulness
supplemental perioperative oxygen to reduce the incidence of post-cesarean endometritis and wound infection

Conditions: Wound Infection or Endometritis Post Cesarean Section

Summary: the purpose of this study is to determine whether supplemental perioperative oxygen significantly decreases the incidence of post-cesarean endometritis and wound infection among women who undergo cesarean section after the onset of labor.

women undergoing cesarean section after rupture of membranes or onset of labor are randomized in a one to one ratio to either normal or supplemental perioperative oxygen during cesarean section and for two hours afterwards.

Eligibility criteria:
inclusion criteria: * women who underwent a clinically indicated cesarean delivery after the onset of labor or rupture of membranes exclusion criteria: * cesarean delivery prior to the onset of labor or rupture of membranes * emergent cesarean delivery * general endotracheal anesthesia * clinical chorioamnionitis * hiv infection * less than 16 years of age

Keywords: women undergoing cesarean section after the onset of labor
the impact of inflammation on skeletal muscle maintenance in hospitalized patients

Conditions: Disease Related Malnutrition; High Systemic Inflammation; Geriatric Assessment

Summary: the main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. we will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. we will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. the hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .


Eligibility criteria:
inclusion criteria: * hospitalised at the geriatric department at bispebjerg hospital with an expected admission time of minimum 7 days * have disease related malnutrition (drm) * able to carry out strength training * able to understand the study information, as assessed by the research team exclusion criteria: * current use of anti-inflammatory medication * liver failure * short bowel syndrome * chrohn's or colitis * terminally ill
dexamethasone dose for postoperative nausea and vomiting prophylaxis in obese patients

Conditions: Postoperative Nausea and Vomiting

Summary: compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients and in normal weight patients.

compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients. compare the effectiveness of dexamethasone given in 4 mg and 8 mg doses in obese patients with 4 mg doses of dexamethasone in normal weight patients. 4 mg iv dexamethasone will be administered to normal weight patients at induction of anesthesia. this group will be classified as the control group. in obese patients (bmi\>30 kg/m2), one group will receive 4 mg dexamethasone and other group will receive 8 mg dexamethasone at induction. patients will receive general anesthesia with volatile anesthetics and tramadol will be administered iv at the end of surgery. postoperative nausea and vomiting, postoperative pain, blood glucose, wound infection, time to oral intake, hospital stay will be compared.

Eligibility criteria:
inclusion criteria: high risk patients for postoperative nausea and vomiting: * female * no smoking * bmi =18.5-24.9 for control group * bmi \>30 for other groups * undergo laparoscopic cholecystectomy exclusion criteria: * diabetes mellitus
mapping the genotype, phenotype, and natural history of phelan-mcdermid syndrome

Conditions: Phelan-McDermid Syndrome; Autism Spectrum Disorder; Intellectual Disability

Summary: the purpose of this study is to comprehensively characterize pms using standardized medical, cognitive, and behavioral measures and to track the natural history of the syndrome using repeated longitudinal assessments. in addition, this study will be aiming to identify biomarkers using neuroimaging, including diffusion tensor imaging and identify genetic factors which contribute to diverse phenotypes in patients with pms.

phelan-mcdermid syndrome (pms) or 22q13 deletion syndrome, caused by a loss of one copy of the shank3 gene, is characterized by global developmental delay/intellectual disability, motor skills deficits, delayed or absent speech, and autism spectrum disorder. the goal of this study is to understand more about the pms phenotype and the biological pathways associated with id and asd in the disorder, and to establish the foundation for future clinical trials in pms and in other id/asd-associated disorders that share signaling pathways with pms. individuals with pms will be asked to participate in this study if they are 18 months or older with pathogenic deletions or mutations of the shank3 gene at time of enrollment, as well as healthy controls. both males and females will be asked to participate. additionally, to be eligible for study participation, individuals' primary communicative language must be english. parents and unaffected siblings may also be asked to consent to have blood drawn for analysis. the study involves 3 on site visits over 2 years. study visits involve a physical exam, medical history questions, blood work and neuropsychological assessments. a subset of participants between the ages of 2 and 11 years old will take part in the eeg portion of the study. individuals who have a clinically indicated mri will have an option to provide routine clinical scans for analysis.

Eligibility criteria:
inclusion criteria: * individuals older than 18 months of age with pathogenic deletions or mutations of the shank3 gene * english speaking individuals exclusion criteria: * has taken an investigational drug as part of another research study, within 30 days prior to study enrollment * for subjects involved in imaging biomarker assessment: contraindications to 3t mri scanning, such as metal implants/non-compatible medical devices or medical conditions, including vagus nerve stimulator * for subjects involved in eeg/ erp biomarker assessment: contraindications to eeg/erp, such as uncooperative or destructive behaviors preventing lead placement or capture by erp/vep equipment. under age 2 or over age 11 at the time of enrollment. * unwilling or unable to comply with study procedures and assessments

Keywords: phelan-mcdermid syndrome pms genotype phenotype natural history mapping 22q13 deletion syndrome shank3 autism spectrum disorder asd intellectual disability id eeg
cingularbio® heart valve clincial study

Conditions: Diseases of Mitral and Aortic Valves

Summary: this study aimed to evaluate the safety and effectiveness of cingularbio® heart valve in aortic valve replacement and mitral valve replacement in chinese population

single arm, 12 month follow up, mutile center, to assess the safety and effectiveness of cingularbio® heart valve in aortic valve replacement and mitral valve replacement patients

Eligibility criteria:
the inclusion criteria were as follows: 1) patient who had heart valve disease requiring a surgical replacement as indicated in the preoperative evaluation; 2) patient aged between 60-85 years; 3) patient whose preoperative heart function less than nyha functional class iv; 4) patient who signed the informed consent before surgery; 5) patient who agrees to finish the follow-up. the exclusion criteria were as follows: 1) patient with prior valve replacement; 2) patient who requires concomitant tricuspid or pulmonary valve replacement; 3) patient who requires concomitant coronary artery bypass graft surgery; 4) patient with active infective endocarditis or drug abuse; 5) patient whose life time expectancy less than 12 months; 6) patient who was unable to follow anticoagulation treatment.
live stream of prehospital point-of care ultrasound by air rescue physicians

Conditions: Echocardiography; Telemedicine

Summary: background: point-of-care ultrasound (pocus) has been suggested as a useful tool in emergency medicine for diagnosis and treatment of reversible causes. however, in prehospital setting performing ultrasound and the translation of the findings can be challenging. as new prehospital ultrasound devices offer the possibility for remote supervision, the impact of tele-supervision on time to diagnosis of critically ill patients is unclear. aims: the aim of this study is to evaluate the impact of tele-supervision on the time of pocus in prehospital critically ill patients by air rescue physicians. methods: in total 100 critically ill patients suffering from acute dyspnoea, circulatory failure or trauma, which are treated by air rescue physicians will be included in this study. duration of ultrasound performance as well as altered treatment strategies will be analyzed.


Eligibility criteria:
inclusion criteria: critically ill patients suffering from acute dyspnoea, circulatory failure or trauma will be included. patients with acute dyspnoea will be included, if they show at least one of the two following signs of respiratory failure: * respiratory rate \> 20 breaths per minute * peripheral oxygen saturation without oxygen supplementation \< 90% patients with acute circulatory failure will be included, if they show at least one of the following signs: * hypotension (systolic blood pressure \<90mmhg) * altered tissue perfusion (cold, clammy, mottling skin or altered mental status) trauma patients will be included, if at least one cause is suspected: * intraabdominal fluid * intrathoracic free fluid * pneumothorax exclusion criteria: * age under 18 * if pocus will lead to a delay of live-saving treatment or transportation

Keywords: ultrasound diagnostics prehospital emergency medicine
deep rectus sheath block for laparoscopic cholecystectomy

Conditions: Cholecystectomy, Laparoscopic; Anesthesia; Postoperative Pain

Summary: postoperative pain after laparoscopic cholecystectomy can be considerable. regional techniques such as erector spinae plane (esp) block or transversus abdominis plane (tap) block may be suitable for patients at increased risk of postoperative pain. the deep rectus shaeth block is a novel block which is a modified version of the conventional rectus sheath block. it was reported in a few case reports that, it may be used for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. the aim of this study is to investigate the postoperative analgesic efficacy of deep rectus sheath block in patients undergoing laparoscopic cholecystectomy.

patients scheduled for elective laparoscopic gastrectomy will be separated into 2 groups: control group and deep rectus sheath block group. patients in control group will be received patient controlled analgesia with morphine for postoperative analgesia. patients in deep rectus sheath block group will be performed deep rectus sheath block at the end of the surgery, along with patient controlled analgesia with morphine for postoperative analgesia. morphine consumption for first postoperative 24 hours, numaerical rating scale scores, amount of rescue analgesic drug, incidence of postoperative nausea and vomiting will be recorded.

Eligibility criteria:
inclusion criteria: * age between 18 and 80 years * patients with american society of anesthesiology (asa) physical status i-ii * patients scheduled for a laparoscopic cholecystectomy exclusion criteria: * allergy to local anesthetics * coagulopathy * skin infection at the deep rectus sheath block area * advanced hepatic or renal failure * chronic pain syndromes * alcohol or drug abuse * severe pulmonary and/or cardiovascular disease * psychiatric disorders