Kornimate/medical-research-clean huggingface dataset:
evaluation of the bone mineral density and muscle mass in patients post coronary artery bypass graft surgery with chronic kidney disease

Conditions: Coronary Artery Bypass Graft; Chronic Kidney Disease

Summary: the purposes of this study are: (1) to compare the body composition, physical activity, physical function, and quality of life between patients with and without ckd after cabg; and (2) to analyze the relationships among body composition, physical activity, and physical function in this population. it is expected that patients after cabg with ckd have the worse body composition, physical function, and quality of life than patients after cabg without ckd; and patients with higher physical activity levels have the better body composition, physical function, and quality of life.

it has been reported that cardiac disease and renal disease frequently coexisted. recently, the term cardiorenal syndrome was used to describe the interaction between heart and kidney. chronic kidney disease (ckd) has become increasingly recognized as an independent risk factor of cardiovascular disease, and the cardiovascular disease is one of most severe complication in patients with ckd. previous studies have showed the changes in body composition, physical inactivity, decreased physical function, and poor quality of life existed in patients with either cardiovascular disease or ckd. patients concomitant with cardiovascular disease and kidney insufficiency were expected to significantly increase physical dysfunction. however, few studies addressed on these alterations in patients after coronary artery bypass grafting (cabg) with ckd were reported.

Eligibility criteria:
inclusion criteria: * patients undergoing cabg without valve surgery * chronic kidney disease(matched group: without ckd) exclusion criteria: 1. heart transplantation or redo cabg 2. amputation, 3. cerebrovascular disease or any others disease with limbs dysfunction, 4. lung deficit, 5. cancer, 6. cognitive disorders.

Keywords: coronary artery bypass grafting chronic kidney disease body composition physical activity physical function
3d analysis of cemento-osseous lesions

Conditions: Bone Diseases; Cone-beam Computed Tomography; Florid Cemento-osseous Dysplasia

Summary: cod lesions effect a wide range of different anatomical areas, show different volume and morphometric characteristics.

fibro-osseous lesions of the jaws are one of the important lesion groups for which identification and diagnosis create clinical difficulties. in previous studies, the features of the lesions and the effects of cod on anatomical structures were analysed via cbct images by measuring the lesion's dimensions linearly for the first time in the brazilian population. however, 3d measurements of the volume need to be taken to assess the actual spread over adjacent anatomical structures. the purpose of this retrospective study is to measure the volume of the lesions that have been diagnosed as cod in the turkish population by using 3d images. this will contribute to an advanced study conducted on the global population to observe a change in these morphologies with respect to different geographical and ethnic origins.

Eligibility criteria:
inclusion criteria: * they were diagnosed with fibro-osseous lesions with the help of cone beam computed tomography between 2017 and 2020 were included in the study. * the lesions diagnosed radiologically and followed up for at least one year were included in this study. exclusion criteria: -radiographs with insufficient diagnostic images were not included.

Keywords: bone diseases cone-beam computed tomography florid cemento-osseous dysplasia
validation of combined pet-mr quantitative parameters for cardiac applications

Conditions: Cardiac Disease

Summary: the purpose of this study is to understand how simultaneous pet/mr acquisition can provide novel qualitative and quantitative biomarkers to guide clinical intervention and predict prognosis of patients with cardiovascular disease.

* to compare regional myocardial uptake of fdg on images obtained on a standard pet camera with the new pet/mr camera, in patients with coronary artery disease. * to compare viability maps obtained with cardiac mr images and fdg-pet for delineation of myocardial infarct core and border zone, in patients with coronary artery disease. * to correlate mri myocardial strain with relative myocardial fdg uptake in patients with a previous myocardial infarction. * to interrogate if simultaneous acquisition of cardiac pet and viability cardiac mr differ from acquisitions obtained independently, with special focus on attenuation correction methods * to combined mri scar map with fdg-pet uptake in patients with cardiac sarcoidosis and myocarditis. * to correlate morphologic characteristics of atherosclerotic disease in the thoracic and abdominal aorta with fdg uptake and ferumoxytol enhancement, as a marker of inflammation. * to evaluate cardiac strain and myocardial scar burden in obese patients with and without diabetes.

Eligibility criteria:
inclusion criteria: * subjects with ischemic and non-ischemic cardiac disease referred for cardiac pet for viability imaging. exclusion criteria: * contraindications for mri, including cardiac pacemaker, claustrophobia, retained metallic foreign body, cochlear implant, aneurysm clip in the brain, pregnancy and egfr less than 45%.

Keywords: positron emission tomography-magnetic resonance imaging cardiac disease
nutrition and pharmacological algorithm for oncology patients study

Conditions: Oncologic Complications; Quality of Life; Nutrition Poor; Head and Neck Cancer; Lung Cancer; Pancreatic Cancer

Summary: loss of appetite is a common symptom of patients with cancer and can cause distress which impacts patients and caregivers. patients diagnosed with head/neck, lung or pancreatic cancer will be recruited for this study to decrease the suffering and distress associated with eating during cancer treatment and improve the quality of life of patients by implementing an algorithm utilizing nutrition intervention and appetite stimulants.


Eligibility criteria:
inclusion criteria: 1. patients with a diagnosis of head/neck, lung, pancreatic cancer, or metastatic cancer from any solid tumor 2. planned, ongoing, or recently treated patient (within the past 30 days) with chemotherapy, immunotherapy, and/or intravenous targeted biologic therapy 3. no previous use of appetite stimulants 4. all patients must sign study specific informed consent prior to being included in the study 5. no contraindication to appetite stimulants exclusion criteria: 1. patient \<18 years old 2. contraindication to appetite stimulants
evaluation of the effect of rtms on attention in adults diagnosed with attention-deficit hyperactivity disorder (adhd)

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the aim of the study is to evaluate the immediate effect of rtms on attention in adults diagnosed with adhd. the design is a double blind sham controlled crossover study.

the subjects were randomly assigned to two groups. group 1 starts with the real rtms session followed within one week with a sham session. group 2 starts with a sham session and within one week recieve a real session. the subjects go through a neurocognitive evaluation before and after rtms sessions and a clinical evaluation questionnaire modified for attention.

Eligibility criteria:
inclusion criteria: * age 18-65 * diagnosis of adhd according to dsm iv criteria exclusion criteria: * other axis i diagnosis * risk factors for seizure

Keywords: adhd
the clinical study of the effect of highland barley diet on blood glucose in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the clinical study of the effect of highland barley diet on blood glucose in patients with type 2 diabetes mellitus

the clinical study of the effect of highland barley diet on blood glucose in patients with type 2 diabetes mellitus. approximately 40 patients will be enrolled in the study from china and randomized in a 1:1 ratio to one of the 2 treatment arms: highland barley diet + metformin; or +common diet metformin. study treatment will continue for 12 weeks. the primary efficacy measure is the change in hba1c at 12 weeks. the study consists of 3 periods: a 1-week screening (period a), a 4-week run-in period (period b) and a 12-week treatment period (period c).

Eligibility criteria:
inclusion criteria: 1. provision of informed consent 2. type 2 diabetic patients （new diagnose ） 3. hba1c ≥7.0 % and \ 7.0 % and ≤ 8.0% at randomization) 4. men and women (non-pregnant and using a medically approved birth-control method) aged ≥ 18 and ≤ 70 years 5. bmi ≥ 23 and ≤ 35 kg/m2 exclusion criteria: 1. type 1 diabetes or other specific types of diabetes 2. pregnancy, preparation for pregnancy, lactation and women of child-bearing age incapable of effective contraception methods 3. uncooperative subject because of various reasons 4. abnormal liver function, glutamic-pyruvic transaminase (alt) and glutamic-oxaloacetic transaminase (ast) \> twice the upper limits of normal 5. impairment of renal function, serum creatinine: ≥ 133mmol/l for female，≥ 135mmol/l for male 6. serious chronic gastrointestinal diseases 7. edema 8. serious heart diseases, such as cardiac insufficiency (level iii or more according to nyha), acute coronary syndrome and old myocardial infraction 9. blood pressure: systolic blood pressure (sbp) ≥ 180mmhg and/or diastolic blood pressure (dbp) ≥ 110mmhg 10. white blood count (wbc) \< 4.0×109/l or platelet count (plt) \< 90×109/l，or definite anemia (hb：\< 120g/l for male, \< 110g/l for female), or other hematological diseases 11. endocrine system diseases, such as hyperthyroidism and hypercortisolism 12. experimental drug allergy or frequent hypoglycemia 13. psychiatric disorders, drug or other substance abuse 14. diabetic ketoacidosis and hyperosmolar nonketotic coma requiring insulin therapy 15. stressful situations such as surgery, serious trauma and so on 16. chronic hypoxic diseases such as pulmonary emphysema and pulmonary heart disease 17. combined use of drugs effecting glucose metabolism such as glucocorticoid tumor, especially bladder tumor and/or family history of bladder tumor and/or long-term hematuria

Keywords: highland barley diet
establishing tcm daycare model and teaching mechanism of depression patients

Conditions: Traditional Chinese Medicine; Major Depressive Disorder

Summary: the teaching platform of the tcm daycare clinics for depression patients will provide a good clinical training environment for the trainees. they can learn how to take care of depression patients by the lectures and the clinical practice experiences in the daycare clinics. they can also learn a holistic approach, a patient-centered healthcare service. this teaching model will strengthen the clinical training of tcm and enhance the international competitiveness of tcm doctors.

major depressive disorder (mdd) is a serious psychiatric illness with a high lifetime prevalence rate and causes major clinical, social and economic burden to patients and their family. despite that more than 40 antidepressants with various mechanisms are available on the market, half of patients fail to achieve remission with optimized medication treatment because of unsatisfactory efficacy, frequent intolerability and poor compliance of pharmacotherapies. however, traditional chinese medicine (tcm) is a safe and effective therapy which has many previous evidences to improve the treatment of depression. the aim of this project is to build up a tcm clinical daycare model for depression patients, and to establish a teaching platform for tcm trainees. the tcm daycare model will be provided by a team organized by doctors, nurses, pharmacists, psychologist, nutritionist and case managers. this model will provide a comprehensive tcm care system to improve the clinical symptoms and quality of life of depression patients.

Eligibility criteria:
inclusion criteria: 1. diagnosis of depression according to dsm-iv (diagnosis code: 296.21-296.30, 300.4) 2. age 18-65 years, male or female 3. evaluation of the 21-item hamilton rating scale for depression (hamd) 8 points or more 4. fully understand the entire research plan and sign the informed consent form (aged 18-20 years old must be jointly signed by a legal agent) exclusion criteria: 1. have a diagnosis of mental illness other than depression in the last or past 6 months, including unipolar major depression, including dyslexia, organic mental disorder, impulse control disorder, substance use disorder, bipolar mental disorder or substance abuse. 2. medical history of patients diagnosed with borderline, antisocial personality disorder 3. take anti-psychotic disorders and anti-epileptic drugs in the past six months. 4. have or may become pregnant 5. a person with serious suicidal ideation or suicide attempt who must be hospitalized for close monitoring
vitamin d serum concentrations & supplementation in children with cerebral palsy

Conditions: Vitamin D Deficiency

Summary: the purpose of this study is to try to correlate vitamin d dosing and dosing adjustment with vitamin d levels, measure affects of seizure medications on levels as well as pathologic fractures and bone density in severely cognitively impaired, non-mobile children and adolescents with cp.


Eligibility criteria:
inclusion criteria: * recorded vitamin d supplementation dose (i.e. prescribed diet and any additional sources of vitamin d) with at least two serum vitamin d concentrations recorded in the medical chart from january 1, 2008 to june 30, 2013. * resident of hlccd since 2008 exclusion criteria: * no vitamin d levels recorded. * history of hyperthyroidism or parathyroid pathology. * short gut syndrome that requires tpn. * poor medical documentation. * heritable disorders that affect vitamin d levels such as pseudovitamin d deficiency rickets, vitamin d resistant rickets, autosomal dominant hypophosphatemic rickets and x-linked hypophosphatemic rickets
compassion and metacognition in schizotypal personality

Conditions: Schizotypal Personality Disorder

Summary: the purpose of this study is to assess the safety and efficacy of a newly developed psychotherapy for schizotypal personality disorder. this new form of psychotherapy integrates compassion focused therapy and metacognitively oriented psychotherapy.

after being informed about the study and potential risks, all patients giving written informed consent will undergo a psychological assessment so as to determine eligibility for study entry. patients who meet the eligibility requirements will be randomized in a double-blind manner in a 1:1 ratio to new integrative psychotherapy or treatment as usual (cognitive behavioral therapy plus standard psychopharmacological treatment). one month after the conclusion of the two forms of treatment (both lasting 6 months), patients will have access to the final follow-up assessment.

Eligibility criteria:
inclusion criteria: - being diagnosed with schizotypal personality disorder at scid-5-ampd exclusion criteria: * being under psychotherapy or psychopahrnacological treatment * being diagnosed with schizophrenia and other psychotic disorders * being diagnosed with bipolar disorder * being diagnosed with intelletual disability * being diagnosed with any neurological disases

Keywords: schizotypy psychotherapy compassion-focused therapy metacognitively oriented psychotherapy metacognition compassion
acupuncture and breast cancer rehabilitation

Conditions: Pain

Summary: the patients were divided into two randomized groups with 24 patients per group, which were given weekly treatment for 10 weeks, one group treated with kinesiotherapy lasting 30 minutes and the other group followed kinesiotherapy the same protocol for another 30 minutes acupuncture using predefined points. the patients were assessed at baseline, after five weeks and at the end of 10 weeks. responded to an evaluation form about their registration and social data. the physical examination included the assessment of shoulder range of motion, shoulder muscle strength, circumference of the upper limbs and the presence of pain. questionnaires of quality of life, upper limb function and depression.

they were included in this study patients undergoing surgical treatment for breast cancer, radical or conservative, and to produce pain in the region of the shoulder girdle and upper limb, including thoracic and cervical spine after three months of surgery. patients over the age of 18 years and level of pain ≥ 3 on the visual analogue scale (vas). patients with bilateral breast surgery were excluded, metastatic disease, vascular disorders and tactile sensitivity, with diabetes mellitus type i and ii uncompensated and with lower level of education than four years. the patients were divided into two randomized groups with 24 patients per group, which were given weekly treatment for 10 weeks, one group treated with kinesiotherapy lasting 30 minutes and the other group followed kinesiotherapy the same protocol for another 30 minutes acupuncture using predefined points. the patients were assessed at baseline, after five weeks and at the end of 10 weeks. responded to an evaluation form about their registration and social data. the physical examination included the assessment of shoulder range of motion, shoulder muscle strength, circumference of the upper limbs and the presence of pain. questionnaires application eorc qlq c30 beck and dash.

Eligibility criteria:
inclusion criteria: * underwent surgical treatment of breast cancer, radical or conservative, * pain in scapular girdle, in the thoracic or cervical spine, after three months surgery. * level of pain ≥ 3 in the visual analogue scale exclusion criteria: * bilateral breast surgery, * metastatic disease, * vascular and tactile sensitivity disorders, * uncompensated diabetes mellitus type i and ii * lower education level than four years.

Keywords: acupuncture breast cancer rehabilitation pain
benefit of allogeneic haematopoietic stem cells in cutaneous t-cell lymphomas epidermotropic with advanced stage and poor prognosis

Conditions: Epidermotropic T-cell Lymphomas

Summary: epidermotropic t-cell lymphomas (etcl), i.e. mycosis fungoides (mf) and its leukemic variant, sézary syndrome, are the most frequent subtypes of cutaneous t-cell lymphomas. mf typically runs an indolent course in its early stages. by contrast, advanced-stage etcls share a very bad prognosis: patients usually show early relapses after chemotherapy, prolonged complete remissions exceptionally occur and quality of life is severely affected. several publications have reported durable responses following allogeneic hematopoietic stem cell transplantation (hsct) in advanced-stage etcls. this study aims to investigate the role of allogeneic hsct in treating advanced-stage etcls. an observational, prospective, multicenter, controlled study will compare the outcomes of patients who receive reduced-intensity conditioned allogeneic hsct from a sibling or 10/10 hla-matched unrelated donor to those of patients who receive standard of care in patients with advanced-stage etcl with poor prognostic features, will be performed. patients are included at the time of donor search irrespective of the results, and compared on a donor versus no donor basis. it is an observational study since no intervention is made except the comparison of outcomes of groups that receive usual care (hsct if donor available, or not).


Eligibility criteria:
inclusion criteria: * age ≥ 18 and ≤ 65 years * histopathologically confirmed diagnosis of international society for cutaneous lymphomas (iscl) / european organisation for research and treatment of cancer (eortc) stage iib, iii, iva or ivb etcl * complete or partial response of the lymphoma (as defined by the international iscl-eortc criteria at the time of inclusion * written informed consent given by the patient * contraception in women of childbearing age * hematopoietic stem cell donor search underway and at least one of the three following criteria: * refractoriness or early relapse (i.e. within one year) after at least one line of systemic chemotherapy (not including skin-directed therapies, methotrexate, interferon-alpha, and oral retinoids) * early histological large-cell transformation, i.e. within two years following etcl diagnosis * histologically proven nodal (iscl / eortc n3) or extra-cutaneous visceral involvement by the lymphoma exclusion criteria: * prior allogeneic hsct * other progressive neoplastic disease * progressive psychotic disease * left ventricular ejection fraction \< 50% (as determined by trans-thoracic echocardiography) * pulmonary disease with fev1, fvc or dlco \<30% of expected corrected for hemoglobin. * creatinine clearance \<50 ml/min or requiring dialysis * transaminases or bilirubin \>two-fold the normal value in the absence of liver involvement by the lymphoma * pregnant or breastfeeding woman * patient with no health coverage * patient under guardianship or curatorship * htlv-1 lymphoma
ovice nurse transition shock and readiness

Conditions: Nurses

Summary: this study aims to investigate the impact of a transition shock program on career entrenchment and readiness for interprofessional learning among newly graduated nurses.

this study aims to investigate the impact of a transition shock program on career entrenchment and readiness for interprofessional learning among newly graduated nurses. hypotheses: h1: after the intervention, the study group will report significantly lower transition shock scores compared to the control group. h2: after the intervention, the study group will report significantly lower career entrenchment scores compared to the control group. h3: after the intervention, the study group will report significantly higher readiness for interprofessional learning scores compared to the control group. h4: there will be a significant interaction effect between time (pre-test vs. post-test) and group (study vs. control), where the study group will show greater improvement in readiness for interprofessional learning and greater reduction in transition shock and career entrenchment compared to the control group.

Eligibility criteria:
inclusion criteria: * 1. newly employed nurses who have worked for less than six months in the profession. 2. nurses who have not received prior transition-related training before participation in the study. 3. nurses willing to participate voluntarily and provide informed consent. exclusion criteria: 1. nurses with previous work experience before their current job. 2. those who decline participation or withdraw from the study. 3. nurses enrolled in ongoing professional development programs related to transition or interprofessional education.

Keywords: novice nurses newly graduated nurses transition to practice transition shock clinical practice readiness