Kornimate/medical-research-clean huggingface dataset:
words generation in compulsives gamblers and parkinson's disease patients

Conditions: Parkinson Disease

Summary: the pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in parkinson's disease associated with a hyperactivity of the motivational system. thanks to the words generation test, which reflects the cortico-subcortical loop functioning, involved in motivation, we want to evaluate and compare using tools (words generation and behavioral tests) the motivational functioning of gamblers and healthy volunteers that we can then compare to that of parkinson's patients with and without behavioral hyperdopaminergic disorders which were explored in another study.

the main objective of this study is to evaluate performance during words generation in gamblers and healthy volunteers compare to those of pd patients with and without hyper-dopaminergic behaviors collected during another study. 2 groups of subjects will be recruited for the study: 20 compulsive gamblers and 20 healthy volunteers each subject will realize twice each test during 2 sessions with one hour in between : during the session 1 : * the test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs. * the test of stroop that assesses selective attention during the session 2: * the test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs. * the task of the casino (iowa gambling test) * the task of landing * the test of stroop we supposed that the performance of compulsive gamblers in words generation test will be higher than those of healthy volunteers, themselves superior to those of pd patients with a hyper-dopaminergic behavior, themselves superior to those of pd patient without hyper-dopaminergic behavior.

Eligibility criteria:
inclusion criteria: for healthy volunteers : * subject from 30 to 75 years old (male and female) * subject with french mother tongue * subject who give their informed and signed consent. * subject affiliated to a social protection program for compulsive gamblers : * subject from 30 to 75 years old (male and female) * subject with french mother tongue * subject with at least 5 criteria of 10 dsm iv diagnostic criteria for pathological gambling * subject who give their informed and signed consent. * subject affiliated to a social protection program exclusion criteria: for healthy volunteers and compulsive gamblers : * presence of apathy defined as a score greater or equal to 14 on the scale of starkstein * presence of severe depression defined as a score greater or equal to 25 on the scale bdi (beck depression inventory) * presence of dementia defined as a score below 25 on the mmse * subject with vision problems making it impossible for the tests * pregnant women * subject under tutelage, curatelle or law protection * subject included in an other clinical study

Keywords: words generation, compulsive gamblers
insulin versus hyaluronic acid in management of periodontal defects

Conditions: Periodontal Diseases; Periodontal Pocket

Summary: in this study, insulin and hyaluronic acid will be used after open flap debridement in treatment of periodontal defects. outcome will be evaluated clinically and radiographically

n this study, insulin versus hyaluronic acid will be used after open flap debridement in treatment of periodontal defects. outcome will be evaluated clinically and radiographically after a follow up period

Eligibility criteria:
inclusion criteria: * patients diagnosed with periodontitis exclusion criteria: * patients with systemic illness that contraindicate periodontal surgery

Keywords: periodontitis insulin regeneration
early diagnosis and treatment of undiagnosed asthma or copd: the ucap 2 trial

Conditions: COPD; Asthma

Summary: our research group has found that canadians with undiagnosed asthma or chronic obstructive pulmonary disease (copd) have increased respiratory symptoms and worse health-related quality of life. the investigators recently developed and validated an on-line questionnaire to accurately identify these symptomatic, undiagnosed individuals. the investigators will advertise in the community asking individuals to complete the on-line questionnaire at home, at their leisure, to determine if they are at risk of asthma or copd. those at risk will be invited to participate in a randomized, controlled clinical trial to determine whether early diagnosis of previously undiagnosed asthma or copd and subsequent treatment by the primary care practitioner will improve their quality of life.


Eligibility criteria:
inclusion criteria: * individuals at least 18 years old * individuals must be symptomatic with respiratory symptoms * individuals must complete the ucap-q questionnaire and score a ≥ 6% probability of having either asthma or copd. * individuals who have given written informed consent to participate in this trial in accordance with local regulations; * individual must be able to perform pre and post bronchodilator spirometry to measure lung function additional inclusion criteria for the randomized controlled trial (rct): * individuals who have undiagnosed airflow obstruction on spirometry testing (i.e. asthma or copd) will be asked to participate in the rct. exclusion criteria: * individuals who report a previous diagnosis of asthma, copd, history of lung cancer, bronchiectasis, interstitial lung disease, cystic fibrosis or other significant diagnosed lung disease. * individuals currently under the care of a respirologist. * individuals currently using inhaled corticosteroids or long-acting bronchodilators. * individuals with history of myocardial infarction, stroke, aortic or cerebral aneurysm, or detached retina or eye surgery within the past 3 months (spirometry is contraindicated) * individuals who are in the third trimester of pregnancy * individuals involved in another interventional trial
impact of the type of stabilization in the two-stage knee reimplantation on reinfection - prospective, randomized study.

Conditions: Knee Infection

Summary: participants after first-stage of knee infection reimplantation will be assign to one of two groups: with stem vs. with sleeve. investigators will check participants on clinical, laboratory and reinfection signs. the main hypothesis is that better mechanical stability of endoprosthesis with sleeves will support infection treatment.

all participants will be treated because of periprosthetic joint infection of the knee, after primary arthroplasty. all participants will be treated with two-stage protocol. in first stage debridement and spacer implantation will be performed. after 6-week antibiotics, when will be absent clinical or laboratory signs of reinfection, second stage will be performed. all participants upon fulfillment all inclusion and exclusion criteria will sign informed consent. with computer software patients will be randomized to one of two groups: with stem vs. with sleeve. after operation all patients will get target antibiotics for 3 weeks. pre-operation and after on periodic controls will checked the knee society score, the western ontario and mcmaster universities osteoarthritis index(womac), visual analogue scale. after 2-year observation evaluation of reinfection rate will be performed in both groups.

Eligibility criteria:
inclusion criteria: * second-stage of knee reimplantation * primary knee replacement in primary knee osteoarthritis * fulfillment of international consensus meeting 2018 infection criteria exclusion criteria: * intraoperative bone defects anderson orthopedic research institute score \>ii * autoimmune disease * diabetes * peripheral vascular disease * congenital or acquired immunodeficiencies * lack of pathogens after first-stage * multi-bacterial infection * multidirectional instability * lack of patient consent

Keywords: knee arthroplasty infection two-stage sleeve stem
assessing diagnostic methods for invasive fungal disease in lung transplant recipients

Conditions: Invasive Fungal Disease; Lung Transplant Recipients; Invasive Pulmonary Aspergillosis; Pneumocystis Jirovecii Pneumonia

Summary: this study aims to assess the diagnostic performance of different tests, including metagenomic next-generation sequencing (mngs), real-time pcr, galactomannan assay, and lateral-flow device tests, in detecting invasive fungal disease in lung transplant recipients using bronchoalveolar lavage fluid samples. the study is retrospective and cross-sectional in design.

this retrospective, cross-sectional study evaluates the diagnostic accuracy of various tests in detecting invasive fungal disease (ifd) in lung transplant recipients. the diagnostic methods under assessment include metagenomic next-generation sequencing (mngs), real-time polymerase chain reaction (pcr), galactomannan (gm) assay, and lateral-flow device (lfd) testing, all performed on bronchoalveolar lavage fluid (balf) samples. the study analyzes the sensitivity, specificity, positive predictive value (ppv), and negative predictive value (npv) of each method for diagnosing invasive pulmonary aspergillosis (ipa) and pneumocystis jirovecii pneumonia (pjp). the sample cohort consists of 109 lung transplant recipients, with data collected from january 2015 to april 2023

Eligibility criteria:
inclusion criteria: * adult lung transplant recipients aged 18 years and older. * suspected cases of invasive fungal infection (invasive pulmonary aspergillosis or -pneumocystis jirovecii pneumonia) based on clinical symptoms, radiological findings, or microbiological evidence. * able to provide sufficient bronchoalveolar lavage fluid (balf) samples for diagnostic testing. exclusion criteria: * patients with confirmed non-fungal infections. * patients unable to provide adequate balf samples for analysis. * patients with severe comorbidities that prevent study participation or completion.

Keywords: mngs real-time pcr galactomannan assay lateral-flow device bronchoalveolar lavage fluid diagnostic methods lung transplantation fungal infection
enhancing the emergency department experience for older adults: study protocol for the implementation of a comfort menu and cart

Conditions: Emergency Department Patient; Comfort

Summary: introduction: the aging of the population is a global phenomenon, with projections indicating a significant increase in the proportion of individuals aged 65 years and older by 2050. this demographic shift requires adapting emergency department (ed) services to meet the specific demands of older patients, who often present with multiple comorbidities and face challenges such as sensory and cognitive difficulties. eds, traditionally designed for acute illness and injury management, may not be adequately equipped to meet the unique needs of this vulnerable population. this can result in suboptimal patient experiences, prolonged ed stays, increased hospitalizations, and poorer outcomes. objective: this study protocol outlines a before-and-after study to evaluate the impact of implementing a comfort menu and cart on the experience and outcomes of older patients treated in the ed. methods: the study will be conducted in the ed of hospital sírio-libanês, a tertiary private hospital in são paulo, brazil. patients aged 65 and older admitted to private ed rooms will be eligible for inclusion. participants will be recruited in two phases: pre-intervention and post-implementation of the comfort menu and cart. data will be collected through patient and staff interviews, chart reviews, and a 30-day follow-up interview. patient experience, staff experience, length of hospital stays, hospital costs, ed readmissions, falls, delirium incidence, quality of life, functional status, cognitive performance, and mortality will be assessed. expected results: a positive impact of implementing the comfort menu and cart in the ed is expected on patient-centered outcomes. improvements in the experience of older patients and medical and multidisciplinary staff are anticipated, and improvements in other exploratory outcomes, such as length of hospital stay, hospital costs, readmissions, falls, delirium incidence, quality of life, functionality, and cognitive performance, will be explored.


Eligibility criteria:
inclusion criteria: * ed attendance at hospital sírio-libanês (hsl), são paulo, brazil. * age ≥ 65 years. * accommodation in a private ed bed, regardless of the indication for hospitalization. * capacity to consent and respond to the interview or the presence of a companion capable of doing so. exclusion criteria: * refusal to participate in the study or use the comfort menu and cart. * absence of a companion able to consent to study participation and provide necessary information for patients with altered mental status or cognitive impairment. * decreased level of consciousness. * hemodynamic instability. * acute respiratory failure. * inability to be contacted by phone for the follow-up interview.

Keywords: comfort cart patient experience older adult emergency department
the change of nk cell activity after head and neck cancer surgery

Conditions: The Patients Undergoing Head and Neck Surgery Including Tumor Removal and Reconstruction With Flap

Summary: cellular immunity can be changed after surgery and anesthesia. tissue injury by surgical procedures significantly reduces the immune function in proportion to the degree of tissue injury. in addition, the use of opioids as analgesics during the perioperative period depress cellular immunity, in particular the activity of the natural killer (nk) cells. this perioperative immunosuppression may cause deleterious consequences on postoperative outcome in cancer patients. the aim of this study is to confirm the presence or extent of the change of nk cell activity between before and after head and neck surgery. additionally, investigators will identify the clinical or genetic factors related to the change of nk cell activity.


Eligibility criteria:
inclusion criteria: 1) the patients undergoing head and neck surgery including tumor removal and reconstruction with flap exclusion criteria: 1. patients refusal 2. patients not able to read, or understand the consent form 3. history of active viral or bacterial infection 4. history of use of immunosuppressive drugs within the last six months 5. history of chemotherapy 6. history of autoimmune disorders 7. known hiv, hepatitis b, or hepatitis c infection 8. female who is pregnant, nursing 9. ethnicity, other than asian

Keywords: natural killer cell head and neck cancer opioid
oral tolerance in cow's milk allergy in the infant

Conditions: Cow's Milk Allergy

Summary: this study aims to determine if there is a link between cow's milk allergy in infants and regulatory t cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others. cow's milk allergy is evaluated by basophils activation test, t cells activation test, specific humoral response (iga, ige, igg) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge. number and function of regulatory t cells and microflora composition are measured at the same time. allergic infants are compared to age matched control group.


Eligibility criteria:
inclusion criteria: male or female, age before 6 month, cow's milk allergy with positive prick or patch test for cow's milk control group: male or female, age before 6 month or within 12 and 18 month, eating cow's milk every day exclusion criteria: immunodeficiency syndrome, lactose intolerance control group: other food allergy, atopic dermatitis.

Keywords: cow's milk allergy, food allergy oral tolerance, infant, regulatory t cells, intestinal microflora
perioperative holistic risk factor screening in the prevention of persistent pain

Conditions: Pain, Chronic Post-Surgical

Summary: assessment and management for improved wellbeing after elective surgery (periscop³e-care) diagnostic assessment tool evaluation and cut-off determination for participation in a transmural perioperative care program

adult patients (≥ 18y) who are planned to undergo an elective surgery at the university hospital antwerp, will be invited to participate. after signing the informed consent, they will be asked to complete questionnaires (periscop3e-care; kalkman \& modified-althaus, dn4, hads, stait-trait, nrs, mpin eq-5d-5l) that involve screening of the risk to develop persistend postoperative pain (ppsp). the questionnaires will be completed via a survey link to the redcap platform. invites will be send out via the patient's e-mail. demograpic data and relevant medical history, surgery history, concomitant medication will be registered. one month and three months post surgery the patients will be contacted to identicate if they developed ppsp. they will also be asked to complete quesionnaires (mpi, hads, stai-trait, nrs, mpi, dn4). based on this info, the cut-off value will be defined for the preoperative questionnaire. analysis will be done for the sensitivity and specificity of the questionnaires.

Eligibility criteria:
inclusion criteria: * adult patiënts (≥ 18 year) * planned elective surgery @ university hospital antwerp exclusion criteria: * incapacitated * cognitive dificit that makes it impossible to complete the questionnaires * language barrier

Keywords: persistent postoperative pain
pulse corticosteroid therapy and effect on brain water diffusivity

Conditions: Systemic Lupus Erythematosus

Summary: in daily clinical use, pulse high dosis corticosteroids are used to treat cerebral edema in different pathological situations ( surgery, trauma, tumors...). dehydration can theorically concern extra-cellular or intracellular water, or both. the relative proportion of those two components are not known, as well their kinetics. diffusion weighted imaging ( dwi) is a none invasive and none toxic technique to study those phenomena.we can also study the diffusivity anisotropy not using a gaussian distribution but rather a non- gaussian one, more close to the reality ( q space imaging ). finally, we can study the compartment redistribution between slow and rapid water molecules diffusion by bi-exponential decomposition of the diffusion signal, corresponding, theorically, respectively to the intra- and extra-cellular component. hypothesis : the high dosis steroid pulse therapy modifies or not the water free diffusion in dwi and qsi ? is there a modification in the diffusivity of both rapid and slow component ?


Eligibility criteria:
inclusion criteria: * systemic lupus erythematosus * normal neurological exam * informed consent * 18 yo or more exclusion criteria: * abnormal neurological exam * younger than 18 years old

Keywords: systemic lupus erythematosus corticosteroid pulse therapy diffusion weighted imaging q space imaging
effect of a unique web-based behaviour change program on weight loss and cardiovascular risk factors

Conditions: Obesity

Summary: web- or internet-based programs have the potential to induce and, possibly, help to sustain, significant lifestyle modification. this study will evaluate the effect of a unique interactive web-based behaviour change program on weight loss and cardiovascular risk factors in people who are overweight or obese and at high risk of cardiovascular disease.


Eligibility criteria:
inclusion criteria: * over 18 years old * have regular access to the internet, telephone and have an e-mail address. * body mass index (bmi) greater than 27 and less than 40 * sedentary * have one or more of the following risk factors associated with cardiovascular disease: elevated blood pressure ≥ 140 mm hg systolic or ≥ 90 mm hg diastolic; elevated total cholesterol ≥ 5.0; type 2 diabetes * be willing to refrain from participating in another behaviour change program for the duration of the study exclusion criteria: * major health problems including type 1 diabetes, established cvd, renal and hepatic disease * psychiatric problems * pregnancy * excessive alcohol consumption

Keywords: behaviour change weight loss cardiovascular risk diet physical activity overweight obesity internet
effectiveness of adalimumab in moderate to severe hidradenitis suppurativa patients - a multi country study in real life setting

Conditions: Hidradenitis Suppurativa

Summary: this study will assess the effects of adalimumab treatment in moderate to severe hidradenitis suppurativa (hs) patients in the real world setting. the objectives of this study are to estimate the effectiveness of adalimumab treatment on disease severity, to estimate the impact of adalimumab treatment on patients' quality of life, psychological effect, work productivity and healthcare resource utilization and to describe treatment practices over the study period.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of moderate to severe hidradenitis suppurativa * the decision to treat with adalimumab (humira) is made by the physician in accordance with the local label (summary of product characteristics; product label) prior to any decision to approach the participant to participate in this study * participants willing to be involved in the study and to sign patient authorization form to use and disclose personal health information (or informed consent, where applicable) exclusion criteria: * participants in a clinical interventional study * participants treated with adalimumab prior to baseline visit

Keywords: moderate to severe hidradenitis suppurativa adalimumab
decision+, a training program to improve optimal drug prescription

Conditions: Acute Respiratory Infections

Summary: decisions about the use of antibiotics for acute respiratory infections are the most frequently reported reason for consulting a family physician. although it varies according to the specific type of acute respiratory infections, the use of antibiotics is estimated to be 63% to 67%, well above the expected prevalence of bacterial infections thus suggesting overuse of antibiotics. consequently, there is an urgent need for helping family physicians and their patients to improve the clinical decision making process regarding the use of antibiotics for acute respiratory infections. we will evaluate the impact of decision +, a multifaceted intervention program that includes training in shared decision making, reminders and feedback targeting physicians, and decision support tools targeting patients on the decision to use antibiotics for acute respiratory infections. results from this study will lay the ground for a national strategy targeting the improvement of the clinical decision making process regarding antibiotic use for acute respiratory infections in primary care. in turn, this will increase quality of care and patient safety.


Eligibility criteria:
family physicians: inclusion criteria: * all fp (teachers and residents) providing care in the walk-in clinic in each family practice teaching unit (fptu) will be eligible to participate in the trial. exclusion criteria: * he/she was involved or participated in the decision + pilot rct * he/she is not expected to be practicing at the fptu for the whole duration of the study (e.g. residents ending their residency program or doing rotations outside of the fptu, planned pregnancy/delivery, planned retirement). patients: inclusion criteria: * if 17 years old and under, must be accompanied by a parents or a guardians) * they are consulting a participating physician for an ari, for which treatment with an antibiotic is considered * they are able (patients or the accompanying parent or guardians) to read, understand and write french (expected level: 8th grade) * they give informed consent exclusion criteria: * patients with a condition requiring emergency care will be excluded.