Kornimate/medical-research-clean huggingface dataset:
anterior screw fixation versus halo immobilization of type ii odontoid fractures in geriatric patients with increased anesthesia risk

Conditions: Spinal Fractures

Summary: the management of type ii odontoid fractures in geriatric trauma victims remains a source of substantial controversy. the purpose of this study was to compare anterior screw fixation with halo-vest-immobilization in patients with type ii odontoid fractures.


Eligibility criteria:
inclusion criteria: * patients aged 65 years or older with an asa (= american society of anesthesiologists) score of 2 or higher * complete sets of collected data and a follow-up monitoring of at least five years exclusion criteria: * type iii odontoid fractures * patients with incomplete data sets * patients with penetrating mechanism of injury or congenital cervical spine anomalies
the role of laparoscopy in upper abdominal surgical emergencies in adults: a retrospective observational study.

Conditions: Acute Abdomen

Summary: introduction laparoscopy can be used to diagnose and treat the etiologies of acute abdominal pain. this study aimed to assess laparoscopy's effectiveness in upper gastrointestinal (g.i.t) emergencies regarding intra-and postoperative outcomes. method: a retrospective observational study was conducted in the emergency departments of zagazig university on 215 patients who had upper abdominal emergency surgeries between june 2017 and june 2020.

when surgical procedures are standardized, laparoscopy's benefits in a range of emergency scenarios are without question acknowledged. when only a basic strategy is set for the surgery, and the surgical approach entirely depends on intra-abdominal findings, the benefits are diminished or unknown. the evidence unequivocally supports the superiority of a laparoscopic approach in numerous emergency cases, such as acute cholecystitis, gastroduodenal perforated ulcers, infected pancreatic necrosis, and splenic injuries laparoscopy gives the primary advantages of a shorter hospital stay, a quicker procedure, and faster recovery without complications. rapid recovery is connected with early enteral feeding. adequate nutritional support aids in maintaining homeostasis and, as a result, enhances immunity, thereby decreasing the incidence of wound infection. laparoscopy should be considered with caution whenever abdominal access is considered difficult, as in cases of organ enlargement, adhesion, and bowel distension. in actuality, creating the pneumoperitoneum is an essential step in the procedure. increased intraperitoneal pressure produces cardio-respiratory and neurological effects. in this study, the investigators designed a retrospective observational study to present our experience in assessing the outcomes of a laparoscopic approach in emergent upper abdominal surgery in terms of intraoperative and postoperative complications.

Eligibility criteria:
inclusion criteria: * clinical diagnoses of upper g.i.t. emergencies, namely acute cholecystitis, perforated p.u., acute necrotizing pancreatitis, and splenic trauma. exclusion criteria: * \< 18 years of age and * open surgeries for upper g.i.t.

Keywords: emergency surgery; laparoscopy; upper abdominal surgery
types of upper limb and hand in patients with cerebral palsy

Conditions: Cerebral Palsy

Summary: cerebral palsy (cp) has been defined as "a group of permanent disorders of the development of movement and posture causing activity limitation(s) that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain". investigators previously developed two classification systems, one for the upper limb and one for the hand, based on 100 films of patients with cerebral palsy. separate classifications were developed following an initial study in which investigators found no correlations between upper limb and hand patterns, meaning that specific upper limb patterns are not always associated with specific hand patterns. thumb patterns were not included in these classifications since robust classifications already exist, moreover thumb patterns are independent from hand patterns. the aim is to evaluate the inter- and intra-rater reliability of two previously developed classifications of upper limb and hand patterns.


Eligibility criteria:
inclusion criteria: * cerebral palsy exclusion criteria: * none

Keywords: cerebral palsy reliability upper limb and hand patterns classification
a phase ii study to evaluate the efficacy, safety and tolerability of azd5069 in patients with uncontrolled persistent asthma.

Conditions: Asthma

Summary: the purpose is to evaluate the efficacy, safety, and tolerability of 3 different doses of azd5069 twice daily as add-on treatment to medium to high dose inhaled corticosteroids (ics) and long-acting β2 agonists (laba), in patients with uncontrolled persistent asthma

a 6-month, randomised, double-blind, placebo-controlled, multi-centre, parallel-group, phase ii study with an optional safety extension treatment period up to 6 months, to evaluate the efficacy, safety, and tolerability of 3 different doses of azd5069 twice daily as add-on treatment to medium to high dose inhaled corticosteroids (ics) and long-acting β2 agonists (laba), in patients with uncontrolled persistent asthma

Eligibility criteria:
inclusion criteria: * men and women aged 18 years and above. females of childbearing potential must use a highly effective contraceptive method plus a condom by their male partner. * diagnosis of asthma for at least 12 months (gina 2011) * uncontrolled persistent asthma, despite treatment with medium to high dose ics and laba, and with a history of exacerbations during the last year * morning prebronchodilator fev1 of ≥30% and ≤85% predicted normal at enrolment * daily use of medium or high dose ics (≥fluticasone 500 µg or the equivalent daily) exclusion criteria: * any clinically significant disease or disorder (including any chronic lower respiratory disease other than asthma) that may put the patient at risk or influence study results * patients with recurrent, latent, or chronic infections * active tuberculosis or latent tuberculosis without completion of an appropriate course of treatment or prophylactic treatment * significant lower respiratory tract infection not resolved within 30 days prior to enrolment * current smoker or smoking history of more than 20 pack years

Keywords: uncontrolled asthma, exacerbation, safety
super-selective intraarterial infusion of cetuximab (erbitux) with or without radiation therapy for the treatment of unresectable recurrent squamous cell carcinoma of the head and neck

Conditions: Carcinoma, Squamous Cell; Carcinoma, Squamous Cell of Head and Neck

Summary: this is an open-label, non-randomized, two arm, phase i research study of superselective intraarterial cetuximab (erbitux) with or without radiation therapy for treatment of recurrent unresectable squamous cell carcinoma of the head and neck (hnscc).


Eligibility criteria:
inclusion criteria: 1. male or female patients of ≥18 years of age. 2. patients with a documented diagnosis of recurrent head and neck squamous cell cancer (squamous cell carcinoma, including nasopharyngeal cancer, or adenoid cystic carcinoma). patients must have at least one confirmed and evaluable tumor site.\* the recurrence must have bidimensional measurements by clinical examination or ct/mri/pet scan. a confirmed recurrence site may also be biopsy-proven 3. tumor recurrence which is surgically unresectable 4. patients must have a karnofsky performance status ≥70% (or the equivalent ecog level of 0-2) (see appendix performance status evaluation) and an expected survival of ≥ three months. 5. patients must have adequate hematologic reserve with wbc≥3000/mm3, absolute neutrophils ≥1500/mm3 and platelets ≥100,000/ mm3. patients who are on coumadin must have a platelet count of ≥150,000/ mm3 6. pre-enrollment chemistry parameters must show: bilirubin\<1.5x the institutional upper limit of normal (iunl); ast or alt\<2.5x iunl and creatinine\<1.5x iunl. 7. pre-enrollment coagulation parameters (pt and ptt) must be ≤1.5x the iunl. 8. patients must agree to use a medically effective method of contraception during and for a period of three months after the treatment period. a pregnancy test will be performed on each premenopausal female of childbearing potential immediately prior to entry into the research study. 9. patients must be able to understand and give written informed consent. informed consent must be obtained at the time of patient screening. 10. patients who refuse surgery. exclusion criteria: 1. women who are pregnant or lactating. 2. women of childbearing potential and fertile men will be informed as to the potential risk of procreation while participating in this research trial and will be advised that they must use effective contraception during and for a period of three months after the treatment period. 3. patients with significant intercurrent medical or psychiatric conditions that would place them at increased risk or affect their ability to receive or comply with treatment or post-treatment clinical monitoring. 4. pre-existing cardiac or respiratory disorders 5. unrelated malignancy within 3 years 6. history of hypersensitivity reactions to other egfr inhibitors 7. metastatic disease 8. less than 6 months from prior radiation therapy (arm 1) 9. previous exposure to cetuximab
artificial intelligence for improved echocardiography

Conditions: Heart Diseases

Summary: the purpose of this study is to assess the effect of artificial intelligence algorithms on image quality in echocardiography.

the study population will be recruited from appointed patients at the clinic of cardiology, st. olavs hospital. after being informed about the study, all patients giving informed consent and meeting the eligibility requirements will undergo their standard clinical echocardiographic exam performed by a sonographer at the clinic. two additional examinations will then be performed by a different sonographer and an expert cardiologist, respectively. in one of the study arms the sonographer randomized to perform the second exam will use the ai algorithm (intervention).

Eligibility criteria:
inclusion criteria: * capacity to consent exclusion criteria: * indication for echocardiographic contrast agents
education session to improve program adherence

Conditions: Weight Management

Summary: to examine is user knowledge of a dietary self-monitoring (dsm) calorie tracking app and improving patient adherence to daily caloric food intake to help with weight loss.

the research question guiding this project is: in adults with a bmi greater than 25 kg/m2, does a 1-hour education session on using a calorie-tracking application improve adherence to a calorie-restricted weight management program over eight weeks? this project aimed to increase patient knowledge with the dsm tool. to increase adherence to the calorie-restricted diet program and, finally, to increase weight loss in the program participants of the 8-week program

Eligibility criteria:
inclusion criteria: * 18 years of age and older with a body mass index (bmi) greater than 25 kg/m2 exclusion criteria: * younger than18 years of age with a body mass index (bmi) less than 25 kg/m2

Keywords: calorie tracking weight loss weight management program food intake
insomnia, physical activity level and stress level

Conditions: Sleep Initiation and Maintenance Disorders

Summary: insomnia is a common, acute, intermittent, or chronic complaint of unwanted sleep difficulties characterized by sleep disturbance. important risk factors leading to insomnia: advanced age, poor health, work stress, shift work, loss of a loved one, divorce, domestic violence, excessive anxiety, repressed personality, perfectionism, neuroticism, alcohol and substance abuse, excessive caffeine intake, excessive smoking, low socio-economic status and low physical activity level. research shows that college students face more sleep problems than the general public. factors that disrupt the sleep hygiene of university students; students' excessive use of computers during lecture and exam periods, exposure to lights and screens for long periods of time, and environmental changes. the aim of this study is to determine the prevalence of insomnia in healthy individuals after the start of face-to-face education in university students after the pandemic period and to determine the physical activity associated with insomnia in this population group. examining levels and other behavioral factors. the research was conducted on students studying at istanbul rumeli university, haliç university and yalova university between march 2022 and august 2022. it will be held online via google forms with students between the ages of 18-25. study data will be collected with the international physical activity survey, demographic data form, sleep hygiene index, distress tolerance scale, and pittsburgh sleep quality index. an application will be made to obtain approval from the haliç university non-interventional clinical research ethics committee. informed consent will be obtained from people participating in the research. statistical analysis of the data will be done with ibm spss 23.0 software.


Eligibility criteria:
inclusion criteria: * between the ages of 18-25, * associate and undergraduate students studying in the field of health sciences * agreeing to participate in the study, * native speaker of turkish, * male and female individuals exclusion criteria: * refusing to participate in the study, * having a diagnosed psychiatric illness, * using any medical medication that affects sleep * having a health condition that prevents physical activity, * be missing data

Keywords: insomnia physical activity stress level
the degree of knowledge and attitude of egyptian nurses regarding emergency management of traumatic dental injuries.

Conditions: Traumatic Dental Injuries

Summary: this study intends to evaluate medical and dental nurses' fundamental knowledge and attitude regarding the management of traumatic dental injuries in egypt.

a master's degree student in the department of pediatric dentistry ,cairo university, will assess the degree of knowledge and attitudes of egyptian nurses regarding emergency management of traumatic dental injuries for all the nurses who will be included in the study sample using soft and hard copies of questionnaire. data will be stored on the investigator's personal computer, secured with a password with backup for the data on google drive and hard copy. the study results will be monitored regularly by the supervisors who will have full access to these interim results to make the final decision to terminate the study. auditing of the study design will be done by the evidence-based committee - faculty of dentistry - cairo university. recruitment strategy will be through giving all medical and dental nurses at each hospital questionnaire forms to solve and return after explaining the items of the questionnaire to them. the study size was calculated using statcalc version 1.4.3 (epi infotm, cdc, atlanta, georgia, usa) and it was a total of 371nurses. statistical analysis will be performed using medcalc software, version 22 for windows (medcalc software ltd, ostend, belgium).

Eligibility criteria:
inclusion criteria: * egyptian nurses who accepted to participate. exclusion criteria: * egyptian nurses who refused to participate.
effect of stellate ganglion block on drooling in parkinson's syndrome

Conditions: Parkinson's Syndrome

Summary: this is a randomized controlled study, including dysphagic patients with parkinson's syndrome who were received in the department of rehabilitation medicine. all patients are randomly allocated to the observation group or the control group. both groups are provided with comprehensive rehabilitation. besides, the observation group additionally undergoes the stellate ganglion block. at admission and after 10-day treatment, functional oral intake scale, drooling amount, depression are assessed.

palliation of dysphagia in patients with parkinson's syndrome continues to be a challenge. this is a randomized controlled study, including dysphagic patients with parkinson's syndrome who were received in the department of rehabilitation medicine. all patients are randomly allocated to the observation group or the control group. both groups are provided with comprehensive rehabilitation. besides, the observation group additionally undergoes the stellate ganglion block. at admission and after 10-day treatment, functional oral intake scale, drooling amount, depression are assessed.

Eligibility criteria:
inclusion criteria: * age \>18 years. * meeting the diagnostic criteria for parkinson's disease developed by the neurology branch of the chinese medical association in 2006. * diagnosed with dysphagia confirmed by the video fluoroscopic swallowing study. * stable vital signs, conscious, able to cooperate with assessment and treatment. exclusion criteria: * dysphagia possibly caused by other reasons, such as cerebrovascular disease, trauma, neuromuscular diseases, malignant diseases of the pharynx and larynx, and digestive tract diseases. * history of mental diseases or use of antipsychotics. * complicated with cognitive impairment or consciousness dysfunction. * simultaneously suffering from severe liver, kidney failure, tumors, or hematological diseases.
a study to evaluate the efficacy and safety of ak111 in subjects with active ankylosing spondylitis

Conditions: Ankylosing Spondylitis

Summary: this is a phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of ak111 in subjects with active ankylosing spondylitis.

the purpose of this study is to evaluate the efficacy and safety of ak111 in the treatment of subjects with active ankylosing spondylitis. subjects will be randomized to receive ak111 or placebo following subcutaneous injection. the study period for each subject will be 25 weeks, including a screening period of up to 35 days, followed by a treatment period of 12 weeks and a follow up period of 8 weeks.

Eligibility criteria:
inclusion criteria: * male or female subjects aged 18-75 years old. * ankylosing spondylitis has been diagnosed for at least 6 months before screening, with radiological evidence that meets the modified new york criteria for ankylosing spondylitis. * bath ankylosing spondylitis disease activity index (basdai) score ≥ 4 and spinal pain score≥ 4 (based on basdai question 2). * subjects received at least 1 kind of non-steroidal anti-inflammatory drugs (nsaids), prior to randomization with an inadequate response or failure to respond. * subjects who are regularly taking nsaids, weak opioids or oral glucocorticoids as part of their as therapy are required to be on a stable dose for at least 14 days before randomization. * subjects taking methotrexate (mtx) (≤25mg/week) or sulfasalazine (≤3g/day) are allowed to continue their medication if started at least 12 weeks prior to baseline, with a stable dose for at least 4 weeks before randomization. exclusion criteria: * subjects with total ankylosis of the spine. * subjects with progressive or uncontrolled diseases of respiratory, circulatory, digestive, urogenital, endocrine, nervous or mental systems, or with other chronic diseases that are not suitable to participate to the study. * subjects with other inflammatory diseases or autoimmune diseases except ankylosing spondylitis (as). * subjects with any severe systemic or local infection within 2 months before screening. * subjects who are using strong opioid analgesics. * combined use of disease modifying anti-rheumatic drugs (dmards) other than methotrexate and sulfasalazine, including but not limited to thalidomide, iguratimod, etc. within 4 weeks before randomization. * received any live vaccine within 2 months before screening or planned to receive any live vaccine during the study period. * previous exposure to secukinumab, ixekizumab or any other biologic drug directly targeting il-17 or il-17 receptor. * received natalizumab or other drugs that regulate b cells or t cells within 6 months before screening. * received more than 2 kinds of tumor necrosis factor alpha(tnf-α) inhibitors before screening.

Keywords: ak111 ankylosing spondylitis
3d -printed single implant overdentures

Conditions: Edentulous Mouth

Summary: a randomized clinical trial (rct) was designed. the participants were randomly allocated into either of the two groups intervention or control group each of 14 participants. participants in control group (group-a) received conventional manufactured implant overdenture while participants in intervention group (group-b) received cad-cam manufactured implant overdenture.

introduction: mandibular single implant overdenture is a well-established treatment modality that address limited financial resources of patients and simultaneously enabled the management of conventional complete denture problems. cad/cam technology helped to mitigate the problems encountered with conventional fabrication techniques, which results in improved dentures fit and retention. therefore, the aim of the current trial study was to evaluate whether overdentures fabricated using cad/cam printed technology exhibited improved patient satisfaction, denture retention, implant survival rate and decreased post-insertion maintenance or not compared to overdentures manufactured using conventional techniques. methods: a randomized clinical trial (rct) was designed. the participants were randomly allocated into either of the two groups intervention or control group each of seven participants. participants in control group (group-a) received conventional manufactured implant overdenture while participants in intervention group (group-b) received cad-cam manufactured implant overdenture.

Eligibility criteria:
inclusion criteria * the participant should be completely edentulous ranging in age from 35 to 75 years * angle's class i skeletal relationship * normal facial symmetry * adequate inter-arch space not less than 12mm * should be a cooperative patient - exclusion criteria: * temporomandibular disorders * uncontrolled diabetes * bleeding disorders or anticoagulant therapy * flabby tissues or sharp mandibular residual ridge * neuromuscular disorders * angle's class ii and iii skeletal relationship. * patients who were heavy smokers * chemotherapy or radiotherapy or with severe psychiatric disorders