Kornimate/medical-research-clean huggingface dataset:
strength for health

Conditions: Colon Cancer

Summary: despite a robust literature on the benefits of exercise for cancer survivors, most of the research to date falls in two primary areas - aerobic exercise and breast cancer survivors. the focus on aerobic training alone is a concern as resistance training is critical for building the muscle mass necessary to maintain physical function. however, concerns have been raised about the potential for higher than tolerated adverse event rates during resistance training, particularly that which is unsupervised, despite a history of safe use of resistance training in other chronically diseased patient populations. the aim of this pilot study is to demonstrate the feasibility, safety and quality of life benefit of a home-based resistance-training program among colorectal cancer survivors. the investigators will recruit n=30 men and women with stage i-iii colon cancer. participants will be randomized to a home-based exercise intervention that combines aerobic and resistance exercise. control arm participants will receive a home-based meditation program.

the investigators will recruit n=30 patients with stage i-iii colorectal cancer and randomize them to a 12-week resistance training intervention with theraband and existing evidence- based materials or attention control using a meditation intervention. using an electronic survey tool, patients will complete a baseline questionnaire on key outcomes (quality of life, fatigue, side effects) and potential confounders and will consent to a medical record review. these will also be assessed via at 4 weeks post randomization and 12 weeks post randomization. participants in the intervention group will receive one-time in person instruction in the exercises derived from the existing evidence base of home-based resistance training programs for older adults and cancer survivors. they will be sent home with a book demonstrating the exercises, a log and a set of appropriate resistance bands. weekly follow-up calls will occur for the duration of the intervention and updates on the call results will be provided to the colon cancer clinic nurse so that care is integrated. participants in the attention control group will be mailed a meditation cd. follow-up in the control group will parallel that of the intervention group, with weekly calls.

Eligibility criteria:
inclusion criteria: * stage i-iii colorectal cancer * completed surgical treatment * at least 12 weeks post-surgery. * at least 4 weeks post adjuvant therapy. * age 18 and older. exclusion criteria: * patients who had surgery more than 24 months ago. * patients with related pre-existing conditions (i.e., crohn's disease, ulcerative colitis, familial polyposis syndromes).
the long term effect of adjustable spaatz 3 intragastric balloon on weight loss

Conditions: Obesity; Diabetes; Hypertension

Summary: this is an open-label trial investigating the effect of spatz 3 intragastric balloon on weight loss on obesity and associated co- morbidities. the study aim is to evaluate the effect of the intra gastric balloon on weight reduction and on related co- morbidities during 1 year of balloon implantation and a year following explantation.


Eligibility criteria:
inclusion criteria: - 1. subjects willing to comply with study requirements and have signed an informed consent form. 2. age 18-70 3. bmi ≥ 35 kg/m² or bmi ≥ 30 kg/m² and hypertension or diabetes mellitus 4. documented negative pregnancy test in women of childbearing potential. 5. women of childbearing potential agree to remain on contraceptives for the duration of their trial participation. exclusion criteria: * 1. subjects receiving any prescription or over the counter weight loss medication within 30 days prior to randomization (including glp-1 analogs). 2. previous gi surgery that could preclude the ability to place the device. 3. subjects with a history of abnormal gi anatomical findings documented on imaging study, which in the opinion of the investigator, may impair implantation of the igb device 4. subjects with severe gerd that are not responding to proton pump inhibitor (ppi) 5. known abnormal pathologies or conditions of the upper gastrointestinal tract. 6. subjects with symptomatic gallstones within 6 months prior to randomization 7. coagulopathy defined as hgb \<10g/dl and platelet \< 100,000/ml or diagnosis of hemophilia, factor x deficiencies or fibrinogen abnormalities 8. subjects requiring prescription antithrombotic therapy (i.e. anticoagulant or antiplatelet agent) 9. subjects unable to discontinue nsaids (non-steroidal anti-inflammatory drugs) or any other drugs with bleeding as a potential side effect during the study duration. 10. subject is or has been enrolled in another investigational study within 3 months of participation into the current study 11. subjects not residing within a 3 hour driving distance of the study center.
hippocampal sparing whole brain radiation versus stereotactic radiation in patients with 5-20 brain metastases: a phase iii, randomized trial

Conditions: Brain Metastases

Summary: this research study is studying two different types of radiation as treatment for brain metastases (tumors in the brain that spread from a cancer that originated elsewhere in the body)

this research study is a phase iii clinical trial. phase iii clinical trials examine the safety and effectiveness of a treatment, often comparing it to another known treatment. in this case, the investigators are specifically looking at differences between two forms of radiation treatment in terms of subsequent quality of life. in this research study, the investigators are comparing stereotactic (focused, pinpoint) radiation (in which each tumor is narrowly targeted) against whole brain radiation (radiation targeting the entire brain) in the treatment of brain metastases. currently whole brain radiation is the standard option for patients with 5-20 brain metastases. stereotactic radiation is the standard option for patients with 1-4 brain metastases. among patients with 1-4 brain metastases, recently published studies suggest that stereotactic radiation results in fewer neurologic side effects than whole brain radiation. it also yields better quality of life in this population. it remains unknown whether stereotactic radiation improves quality of life in patients with 5-20 brain metastases relative to whole brain radiation. in this study, the investigators seek to determine which of the two methods of study treatment results in a better subsequent quality of life for patients with 5-20 brain metastases.

Eligibility criteria:
inclusion criteria: * participants must have a biopsy proven solid malignancy with untreated (by radiation) intracranial lesions radiographically consistent with or pathologically proven to be brain metastases. patients who have undergone prior systemic therapy are eligible * five-twenty intracranial lesions must be present on mri of the brain * age 18-80 years at diagnosis of brain metastases * karnofsky performance status of at least 70 exclusion criteria: * participants who have undergone prior radiation for brain metastases. * patients who have undergone resection of one or more brain metastases but who have not yet started adjuvant radiotherapy are eligible for the study * participants who cannot undergo a brain mri * participants who cannot receive gadolinium (mri contrast) * participants with stage iv-v chronic kidney disease or end stage renal disease * participants with widespread, definitive leptomeningeal disease * participants with small cell lung cancer, lymphoma, or myeloma * participants with a maximum tumor diameter exceeding 5 cm (if not resected)

Keywords: brain metastases brain metastasis lung cancer melanoma breast cancer kidney cancer renal cell carcinoma stereotactic radiation stereotactic radiosurgery srs stereotactic whole brain radiation wbrt hippocampal avoidance hippocampal sparing hippocampal hippocampus radiation quality of life neurocognitive neurocognition survival salvage mdasi chemotherapy recurrence
effectiveness of music practical examinations

Conditions: Test Anxiety; Stress

Summary: college student anxiety is rising alarmingly and directly affects academics, occupations, and well-being. occupational therapy (ot) students encounter a rigorous workload and pressure to become entry-level practitioners. higher education faculty strive for evidence-based teaching strategies and effective classroom management and are often challenged to promote a positive classroom culture. this quasi-experimental study explored the effect of listening to music during a lab practical examination on the performance of ot graduate students.

through convenience sampling, 68 graduate students in an occupational therapy program were recruited to participate. the quasi-experimental study was conducted at russell sage college, in troy, new york, with approval from the international review board inclusion criteria were male and female first and second-year students, ages 19-34, enrolled in functional anatomy and kinesiology or physical agent modalities. the data was collected during lab practicals in december 2021 and june 2023. forty-three students signed consent forms to participate. students sign up for 20-minute time slots in pairs for the practical exam. each student randomly selects confidential assessment cards and takes turns independently completing their assignment. each practical contains a grading rubric, and a score of 80 is required to pass. students either had one private room when an examiner during the practical, and either it was quiet or low 60 bpm music played in the background. pre and post-outcome measures evaluated each student's state, trait, test anxiety, blood pressure, and heart rate outside the assessment room. state and trait anxiety was measured using the state-trait anxiety inventory for adults™ by charles d. spielberger and the test anxiety inventory by charles d. spielberger \& associates. state-trait anxiety is cited in over 20,000 articles and is the primary assessment used most often for individuals susceptible to anxiety. the reliability of the state-trait anxiety is .86 - .95, and substantial evidence confirms its validity. mean s-anxiety .59, t- t-anxiety .57 college students of both sexes. the test anxiety inventory measures individual situational anxiety of symptom frequency throughout an exam, like apprehension and nervousness. remote online survey licenses were purchased to administer the state-trait anxiety adult and test anxiety inventory on each student's laptop. mind garden's transform system collected raw scaled scores. the research team recorded blood pressure and heart rate with the digital blood pressure monitor with an upper arm cuff.

Eligibility criteria:
inclusion criteria: * graduate occupational therapy students enrolled in functional anatomy and kinesiology or physical agent modalities exclusion criteria: * students not registered for functional anatomy and kinesiology or physical agent modalities
retinal laser by multi-spot photocoagulator and driving eligibility

Conditions: Proliferative Diabetic Retinopathy

Summary: the purpose of this study is to determine the risk of failing the visual field criteria to hold a driving license following retinal laser treatment delivered with a multi-spot photocoagulator.

despite improvements in the management of diabetes, the incidence of severe diabetes -related eye disease remains high. laser treatment (panretinal photocoagulation (prp)) is the gold standard treatment for reducing the risk of visual loss. however, evidence suggests that prp can be damaging on visual field function and thus jeopardize patients' eligibility to drive. in the uk, it is the patient's responsibility to inform the dvla that they are receiving retinal laser. with the use of a multi-spot photocoagulator for application of prp at moorfields the investigators are in a unique position to assess the effects of laser applied with this new delivery system on visual fields in a detailed fashion. thus providing more accurate advice on visual prognosis and visual field function and addressing the risk of losing the ability to drive. all treatment-naive patients with severe diabetic retinopathy requiring bilateral retinal laser treatment will be identified. following informed consent these patients will undergo baseline visual field testing which will be of a duration of approximately 30 minutes and complete a quality of life questionnaire. all patients will receive their laser treatment as part of standard clinical care via the multi-spot photocoagulator which will require approximately four 20 minute sessions. at 6 months following the completion of treatment the patients will undergo repeat visual field testing as conducted at baseline and complete a quality of life questionnaire. the investigators hope to recruit 100 patients. analysis of visual fields will principally involve assessment of whether patients have met the uk driving standards on estermann vf testing. a quantitative assessment of change in retinal sensitivity will be undertaken by comparing retinal sensitivity pre and post-prp.

Eligibility criteria:
inclusion criteria: * patients of either sex aged 18 years or over. * diabetes mellitus (type 1 or type 2). * best corrected visual acuity (bcva) \> or equal 6/60 in both eyes. * requiring full bilateral prp. * no previous laser treatment. * subject cooperation sufficient for adequate visual field testing. * ability to return for regular study visits. exclusion criteria: * co-existent ocular/systemic condition that may affect visual field. * visual acuity less than 6/60 that may affect accuracy of visual field test. * presence of vitreous haemorrhage. * intraocular surgery/other intervention anticipated in either eye during the duration of treatment and vf assessment. * previous prp. * age below 18.

Keywords: proliferative diabetic retinopathy pan retinal photocoagulation multi-spot photocoagulator visual field tests
desiccated thyroid extract and levothyroxine for hypothyroidism treatment

Conditions: Primary Hypothyroidism.

Summary: our hypothesis is that hypothyroid patients on dte may have a decrease in symptoms, an improvement of cognitive function, and an increase in sense of well-being/ quality of life equivalently compared with l-t4.


Eligibility criteria:
inclusion criteria: * patients will be between the ages of 18 to 65 and will have been on levothyroxine for primary hypothyroidism for at least 6 months. exclusion criteria: * patients will be excluded if they have the following problems: pregnancy, plan for pregnancy in the next 12 months, cardiac disease, especially coronary artery disease, chronic obstructive lung disease, malabsorption disorder, gastrointestinal surgeries, significant renal or liver dysfunction, seizure disorders, thyroid and non-thyroid active cancers, uncontrolled psychosis, psychotropic medication use, steroid use, amiodarone, chemotherapy for cancer, iron supplement more than 325mg per day, carafate/ proton pump inhibitor use, cholestyramine use, and those with recent pcs orders who are expected to move out of the geographic area, age less than 18 years old or older than 65 years old. * patients scheduled for deployment will be excluded.

Keywords: desiccated thyroid extract and levothyroxine
local or systemic effects: mechanisms related to arm crank exercise - comparison between individuals with and without pad

Conditions: Peripheral Arterial Disease

Summary: introduction: exercise with an arm ergometer (eb) overcomes the main barrier to physical exercise in patients with peripheral artery disease (pad), leg pain during walking. due to its aerobic nature, this type of exercise can cause systemic changes in the regulatory mechanisms of vasodilation. in other words, it provides vascular benefits in the most affected arterial beds in the pad population. objective: to analyze local and systemic vascular responses, as well as cell signaling pathways after an eb exercise session in patients with pad and their peers without pad. methods: 24 patients with pad and 24 individuals without pad will be recruited, matched by sex and age. participants will undergo two experimental sessions in approved order (eb and control). the eb session will consist of 15 cycles of 2 min of exercise with an intensity equivalent to 13-15 on the borg scale of perceived exertion. before and after the experimental sessions, the vascular function of the brachial and femoral arteries, blood indicators of vasodilation and calf muscle oxygenation will be evaluated. to analyze the acute effect between groups on cardiovascular parameters, a three-way analysis of variance will be performed, taking as factors disease (presence vs. absence), session (eb vs. control) and time (pre vs. post). in all analyses, when a significant effect is selected, the bonferroni or newman-keuls post-hoc test will be used. for all analyses, a value of p\<0.05 will be considered significant.


Eligibility criteria:
inclusion criteria: * if female, must be postmenopausal without hormone replacement therapy; * non-smokers; * with a body mass index (bmi) not exceeding 30 kg/m²; * with calf skinfold thickness below 20 mm, due to the interference of adiposity in the penetration of light from the nirs probe, and oxygen saturation in the finger \>95% to ensure that impaired pulmonary gas exchange does not affect oxygen saturation measurements in the calf; * not using classic antioxidants or vitamin supplements; and * physically capable of performing an exercise session. * for the group of participants with pad, in addition to the criteria mentioned above, they must have a confirmed diagnosis of the disease, characterized by an ankle-brachial index (abi) lower than 0.90 in one or both legs, exhibit symptoms of claudication during walking, and be physically capable of performing an exercise session to participate in the project. exclusion criteria: * only participants who discontinue their participation in the study protocol will be excluded from the sample

Keywords: intermittent claudication exercise vascular function
laparoscopic ventral mesh rectopexy versus trans-vaginal repair for anterior rectocele.

Conditions: Rectocele; Anterior Rectocele

Summary: this study aims to compare the effect of laparoscopic ventral mesh rectopexy versus trans vaginal repair in management of anterior rectocele in females regarding functional outcomes.

rectocele is the protrusion of the anterior wall of the rectum into the vaginal lumen through the rectovaginal fascia and posterior vaginal wall. symptomatic rectocele affects postmenopausal women and causes obstructed defecation significant rectal emptying difficulties, straining at defecation, manually assisted defecation, the need for perineal or vaginal digitation, and local symptoms such as vaginal bulging and pelvic heaviness in 30-70% of cases have been described as symptoms of rectocele . constipation can be managed with dietary measures, laxatives, and biofeedback training , which can be beneficial for patients with modest symptoms. surgical treatment is recommended if conservative treatment fails to alleviate symptoms . however, some patients may be left with constipation, fecal incontinence, incomplete bowel evacuation, or sexual dysfunction despite the correction of the anatomical defect. the selection of patients for surgical intervention for symptomatic rectocele remains a matter of debate. there is still a controversy between abdominal approaches and the transanal, transperineal, and transvaginal approaches as the optimal surgical approach to treat complex rectocele. while the latter is preferred by gynecologists, the former has increased in popularity among colorectal surgeons, aided in part by the growing interest in minimally invasive surgery. this study aimed to evaluate the outcome of lvmr in comparison with tvr of anterior rectocele regarding the improvement in constipation score and sexual-related quality of life, surgical outcomes and postoperative complications.

Eligibility criteria:
inclusion criteria: * female patients aged between 30 and 60 years, presented with symptomatic rectocele with failed conservative treatments. * anterior rectocele larger than 3 cm in size with retention of the contrast in the rectocele on defecography. * excessive straining, sense of incomplete evacuation, the need for digital manipulation during defecation, or dyspareunia. exclusion criteria: * significant urinary manifestations due to anterior vaginal wall prolapse. * patients with recurrent rectocele * complete external rectal prolapse * isolated anismus * connective tissue disease * patients with slow-transit constipation * fecal incontinence (fi), or abnormal thyroid function.

Keywords: transvaginal repair ventral mesh rectopexy laparoscopic
study evaluating 111in-panitumumab for nodal staging in head and neck cancer

Conditions: Head and Neck Cancer

Summary: the primary purpose of the study is to assess the safety of 111in-panitumumab as a molecular imaging agent in patients with head and neck squamous cell carcinoma. the secondary objective is to compare sensitivity and specificity of identifying sentinel lymph nodes by systemic injection of 111in-panitumumab prior to day of surgery versus conventional local injection with an optical dye at the time of surgery.


Eligibility criteria:
inclusion criteria: * biopsy confirmed diagnosis of squamous cell carcinoma of the head and neck. * subjects diagnosed with any t stage, any subsite within the head and neck that are scheduled to undergo surgical resection. subjects with recurrent disease or a new primary will be allowed. * planned standard of care elective neck dissection for a cn0 or cn1 disease. clinical n1 disease will be defined as metastasis in a single, ipsilateral lymph node, 3 cm or less in greatest dimension by clinical exam, cross sectional imaging or metabolic imaging. * have acceptable hematologic status, coagulation status, kidney function, and liver function including the following clinical results: * hemoglobin ≥ 9 gm/dl * white blood cell count \> 3000/mm3 * platelet count ≥ 100,000/mm3 * serum creatinine ≤ 1.5 times upper reference range exclusion criteria: * myocardial infarction (mi); cerebrovascular accident (cva); uncontrolled congestive heart failure (chf); significant liver disease; or unstable angina within 6 months prior to enrollment. * history of infusion reactions to monoclonal antibody therapies. * pregnant or breastfeeding. * magnesium or potassium lower than the normal institutional values. * subjects receiving class ia (quinidine, procainamide) or class iii (dofetilide, amiodarone, sotalol) antiarrhythmic agents. * subjects with a history or evidence of interstitial pneumonitis or pulmonary fibrosis. * severe renal disease or anuria.