Kornimate/medical-research-clean huggingface dataset:
ventral abdominal hernia repair with self adhering, atraumatic mesh

Conditions: Abdominal Hernia

Summary: patients who underwent ventral abdominal hernia repair with self adhering, atraumatic mesh in sublay position are examined for their recurrence rate

the study includes all patients operated from 11.03.2014 to 31.12.2020. patients will undergo a sonography at least one year after surgery. the patients operated form 11.03.2014 to date are therefore a retrospective cohort, the patients from to date until 31.12.2020 a prospective cohort. this method is used to achieve the highest possible number of patients in a define period of time with no alteration of surgical technique. all patients in the retrospective cohort are contacted at least 1 year after surgery and/or 3 years after surg ery via phone call or letter, informed about the study and asked to participate. in case of informed consent, they are invited to the study site. they are asked to complete the questionnaires and they undergo a sonography of the ventral abdomen. all patients in the prospective cohort are informed about the study and asked to participate in the outpatient clinic before surgery. in case of informed consent, they are invited to the study site at least one year and three years, respectively, after surgery. they are asked to complete the questionnaires and they undergo an ultrasound of the ventral abdomen. the latest follow up should be completed by 31.03.2022. for both, the retro- and prospective arm, the time needed for the follow-up appointment is approximately 1 hour. the completion of the ultrasound is estimated to take 20 minutes, the questionnaires is estimated to take 20-30 minutes.

Eligibility criteria:
inclusion criteria: * age older than 18 years * initially suffering from ventral abdominal hernia * performance of open ventral abdominal hernia repair with self-adhering, atraumatic mesh (adhesix ®) * informed consent as documented by signature (appendix: informed consent form) exclusion criteria: * inability to comply with the study protocol

Keywords: abdominal hernia ventral hernia atraumatic mesh
correlation between a novel subset of neutrophil and corneal neovascularization.

Conditions: Corneal Neovascularization; Neutrophils

Summary: the purpose of this study is to determine whether a novel subset of neutrophils is correlated with corneal neovascularization in the patients suffered from ocular chemical injury.

cornea is an avascular transparent tissue providing refractive power for suitable optical performance. but under the condition of injury or infection, the stable microenvironment of ocular surface has been destroyed. vessels sprout from the limbus to form corneal neovascularization, becoming an important pathological feature and leading cause of blindness. however, the underlying mechanism particular the inflammation-mediated mechanism remains unclear. with the advancement of single-cell rna sequencing (scrna-seq), the investigation of immune cell transcriptomes has obtained great process . using this advanced method, we identified different immune cell types in the ocular surface microenvironment in corneal neovascularization mouse model. particularly, we found a specific subset of neutrophils played important role during the corneal angiogenesis. using the loss-of-function and gain-of-function experiment, we clarified that this novel subset of neutrophils is the major factor that promoting corneal angiogenesis in mouse model. to further explore the relationship between this subset of neutrophils and angiogenesis in human, we plan to detect whether the neutrophil subset is increased in the circulation of chemical burned corneal neovascularization patients. the main purpose of this study is to assess whether the novel subset of neutrophils has correlation with chemical burned corneal neovascularization. approximately 33 patients and 33 age matched healthy controls will be recruited. the clinical characteristics, 4ml peripheral blood and the images of slit lamp photography will be obtained.

Eligibility criteria:
inclusion criteria: diagnosed ocular chemical injury with or without corneal neovascularization. exclusion criteria: 1. those who are diagnosed ocular diseases except for chemical ocular injury, such as uveitis, retinopathy. 2. those who are diagnosed allergic disease, autoimmune diseases or hematological diseases, infectious disease, such as eczema, systemic lupus erythematosus (sle), agranulocytosis and viral hepatitis. 3. those who took immunosuppressive treatments in the past 3 months. 4. pregnant or nursing women. 5. those who have serious heart, lung, liver or kidney diseases. 6. those who have serious systemic diseases. 7. those who performed ocular surgery (including cataract surgery) in recent three months. 8. those who have been enrolled in other interventional clinical studies at the same time. 9. those who are unable to complete the study according to the investigators' requirements.
efprezimod alfa (cd24fc, mk-7110) as a non-antiviral immunomodulator in covid-19 treatment (mk-7110-007)

Conditions: Coronavirus Disease 2019 (COVID-19)

Summary: this study evaluates the efficacy and safety of efprezimod alfa in hospitalized adult participants who are diagnosed with coronavirus disease 2019 (covid-19) and receiving oxygen support. the primary hypothesis of the study is clinical improvement in the experimental group versus the control group.


Eligibility criteria:
inclusion criteria: * diagnosed with coronavirus disease 2019 (covid-19) and confirmed severe acute respiratory syndrome coronavirus 2 (sars-cov-2) viral infection * severe or critical covid-19, or national institute of allergy and infectious diseases (niaid) 8-point ordinal score 2, 3 or 4 (scale 2: requiring invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo); scale 3: non-invasive ventilation or high flow oxygen devices; scale 4: supplemental oxygen support; a peripheral capillary oxygen saturation (spo2) \ /= 24 breaths/min). intubation should be within 7 days exclusion criteria: * participants who are pregnant, breastfeeding, or have a positive pregnancy test result before enrollment * participants previously enrolled in the efprezimod alfa study * intubation for invasive mechanical ventilation is over 7 days * documented acute renal or hepatic failure * the investigator believes that participating in the trial is not in the best interests of the participant, or the investigator considers unsuitable for enrollment (such as unpredictable risks or subject compliance issues)
assessment of mandibular bone invasion with mri using swift

Conditions: Oral Cancer

Summary: the primary objective of this study is to improve the diagnostic accuracy and specificity of mri in detecting the degree of bone involvement and invasion in oral cancer. the presence and degree of bone invasion determines the extent of surgery and has great effect on the morbidity of patients with oral cancer and bone/soft tissue tumors. mri scanning in 3 tesla (3t) and 4tesla (4t) mr magnet will be performed on up to 10 patients with possible maxillofacial and/or mandibular bone invasion. we will then compare the conventional imaging results of the patients with 3t and 4t mri results and post operative pathology results.

unfortunately, detecting bone invasion and extension of bone involvement prior to surgery is often difficult with the currently available imaging techniques. mri with high contrast resolution and the ability to perform multiplanar imaging plays an integral role in the delineation of tumoral involvement of the bone. although mri is an excellent tool in the assessment of bone invasion in carcinoma, its overestimation of cortical invasion and tumor extent to the bone marrow have been a diagnostic challenge, leading to false positive results. like many of the musculoskeletal system tissues, cortical bone produces no signal with conventional mri techniques, limiting the characterization of image contrast and differentiation of adjacent soft tissues. a novel mri technique called sweep imaging with fourier transformation (swift) appears to be a suitable tool to overcome this challenge. the main advantage of swift is to obtain signal from the cortical bone. we believe that the swift technique will overcome the false positive results. patients enrolled in this study will be asked to come to the center for magnetic resonance research (cmrr) at the university of minnesota, minneapolis, minnesota for a scheduled mri. brief scans will be obtained (less than 1 minute) to localize the area of interest. longer mri scans (around 5-15 minutes each) will then be obtained. the total time required for scanning will be about 1 hour. to determine how well our mr images will predict the presence of mandibular invasion, we will compare our results with clinical, operative, radiological and pathological findings. thus, patients will be asked to give permission to the investigators to access the relevant medical records.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of oral cancer with clinical or imaging findings suggestive of maxillofacial or mandibular bone invasion. * patients who will be undergoing surgery as treatment for their oral cancer. exclusion criteria: * pregnancy * ferromagnetic implant * history of shotgun wounds and shrapnel * obesity (\>250 pounds) * cardiac pacemaker * mr incompatible medical device * severe claustrophobia * surgeries with potential ferromagnetic implants * metallic ink tattoo in close proximity to area of interest.

Keywords: oral cancer mandibular invasion swift mri
adherence to palivizumab prophylaxis

Conditions: Congenital Heart Disease in Children; RSV

Summary: the goal of this clinical trial is to analyze implications of two alternative nudge-interventions to increase adherence to palivizumab prophylaxis in children with congenital heart disease. the main questions investigators aim to answer are: * are well-established cognitive biases effective in increasing patient families' adherence to the palivizumab prophylaxis program? * what are the factors that affect families' adherence to the prophylaxis program and whether and how the effects of interventions depend on these factors? to study these questions investigators planned to utilize four well-established cognitive biases in designing two alternative nudge-interventions and investigators measured the effectiveness of each nudge-intervention against a control group. patients were randomly allocated to one control and two treatment groups. in the control group, investigators informed participants about the prophylaxis program and provided a schedule. patients in the first treatment group were additionally called two days before appointments (status quo bias), and were asked to plan the appointment day (implementation intention). patients in the second treatment group received biweekly messages informing them about the benefits of the program as well as the current adherence rate (availability bias and social norm).


Eligibility criteria:
inclusion criteria: * diagnosis of congenital heart disease which are hemodynamically unstable, congestive heart failure, diagnosis of congenital heart disease with hemodynamically significant residual defects after corrective heart surgery, cardiomyopathy, pulmonary hypertension * being between 0-2 years of age exclusion criteria: * diagnosis of congenital heart disease in which palivizumab prophylaxis is not needed (the diagnosis of congenital heart diseases which are hemodinamically stable.) * becoming exitus during prophylaxis program * not being between 0-2 years of age
a post-marketing surveillance to assess safety and efficacy of besivo

Conditions: Chronic Hepatitis b

Summary: this study is a post-marketing surveillance of besivo in participants with chronic hepatitis b.

this post-marketing surveillance required by korea mfds regulation. the objectives of this study are to monitor adverse events and effectiveness of besivo.

Eligibility criteria:
inclusion criteria: * the patient diagnosed with chronic hepatitis b. * the patient who is first prescribed and administered besivo. exclusion criteria: * the patients who are overreacting to this drug or its components * medium to severe renal function disorder * the patient under 19 * the patient who are taboo with l-carnitine
the active intervention to improve hospice care

Conditions: Pain

Summary: the active intervention to improve hospice caregiver pain management the major goal of this project is to implement and test this promising intervention in three hospice programs. the mixed methods evaluation of this randomized controlled trial (rct) will provide evidence-based data for a tested intervention manual that hospice staff members can use to integrate the intervention into their practices.

the active intervention to improve hospice caregiver pain management the major goal of this project is to implement and test this promising intervention in three hospice programs. the mixed methods evaluation of this rct will provide evidence-based data for a tested intervention manual that hospice staff members can use to integrate the intervention into their practices. we will rigorously test the effectiveness of the active intervention. we will investigate whether the assessment of the informal caregivers perception of pain management will identify those who will benefit most and whether changes in the perceptions of informal caregivers will result in improvement of patient pain. we will explore barriers and challenges in the implementation of this into every day practice within hospice

Eligibility criteria:
inclusion criteria: informal caregiver inclusion criteria 1. informal caregiver of an enrolled hospice patient 2. age 18 or over and legally able to provide informed consent 3. involved in decisions related to pain medications 4. access to at least one of the below: 1. a standard land line telephone 2. a high-speed internet connection with operational computer 5. without functional hearing loss or with a hearing aid that allows the participant to conduct phone or internet conversations as assessed by the research staff (by questioning and observation - exclusion criteria:informal caregivers of hospice patients with a life expectancy less than 14 days as assessed by the hospice nurse with the palliative performance scale (pps) (99) -

Keywords: hospice caregivers interdisciplinary team pain management
advancing identification of circadian delay in adhd youth: associations with clinical heterogeneity and cognition

Conditions: ADHD - Attention Deficit Disorder With Hyperactivity; ADHD

Summary: the purpose of this study is to better understand sleep and circadian functioning in children with adhd using home-based measures, parent report, and a lab based melatonin assessment. investigators will also examine how sleep relates to psychiatric health and cognition among children with adhd. the investigator for this study is dr. jessica lunsford-avery from the department of psychiatry.

participants will be asked to review and sign a consent form to enroll. as part of the study, participants will: * attend three study visits where they will be asked to complete questionnaires and assessments related to their child's attention and behavior, psychiatric health, and sleep habits. one of these visits is a lab-based melatonin assessment at night. * be asked to have their child wear a device (similar to a wrist watch) for a 7-day period. parents will also be asked to complete an electronic daily diary about their child's sleep. * be asked to have their child wear a skin temperature sensor each evening after dinner until they wake up the next morning. * be asked to use a mattress sensor which measures movement, sleep state, and heart rate. participants will be compensated for their time.

Eligibility criteria:
inclusion criteria: * ages 6-9 * meets dsm-5 criteria for adhd, any presentation * iq \> 80 * healthy * if applicable, willing to suspend melatonin usage during the study period exclusion criteria: * meet dsm-5 criteria for psychosis, bipolar, or autism spectrum disorders * diagnosis of occult sleep disorders, including sleep apnea or restless leg syndrome * medication for sleep other than melatonin * plans to initiate stimulant medication during the study period.

Keywords: adhd attention deficit disorder with hyperactivity circadian rhythm dim light melatonin onset
proteomic study of chuanhong zhongfeng capsule in the treatment of aci

Conditions: Acute Ischemic Stroke

Summary: acute cerebral infarction is characterized by high disability rate and high recurrence rate, which poses a great threat to the life and health of the nation. proteomics technology is a holistic and comprehensive understanding of disease mechanism, cell metabolism and other processes at the protein level. the correlation between acute cerebral infarction and proteomics has become a hot spot of clinical and basic research in recent years. chuanhong zhongfeng capsule was developed by ren jixue, a master of national medicine, and clinical studies have confirmed that it not only promotes the recovery of neurological function in patients with cerebral infarction, reduces the disability rate, but also improves the long-term prognosis, but its mechanism of action and its target are still unclear. in the present study, we applied 4d label-free proteomics technology and prm technology to study for the first time the mechanism of action and potential targets of chuanhong zhongfeng capsule in the treatment of acute cerebral infarction, which will provide a direction for the study of traditional chinese medicine compounding for the prevention and treatment of cerebral infarction.


Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria for ischemic stroke in the chinese guidelines for diagnosis and treatment of ischemic stroke in the acute phase 2018. 2. meet the diagnostic criteria for ischemic stroke in chinese medicine. 3. within 2 weeks of acute onset of ischemic stroke. 4. 4 ≤ nihss score \<15. 5. age 40-80 years old. - exclusion criteria: 1. diagnosis of hemorrhage or other pathological brain disorders based on head ct or mri; 2. allergic individuals, those who are allergic to the test medication or the associated medicinal flavors or components thereof; 3. age \ 80 years; 4. those with severe liver or kidney function impairment. -
cognitive behavioral therapy to help hiv infected adults with depression to adhere to antiretroviral therapy

Conditions: Depression; HIV Infection

Summary: this study will compare the effectiveness of a cognitive behavioral intervention versus usual clinic care in helping hiv infected adults with depression to take their hiv medications on schedule.

antiretroviral therapy (art) is a type of medication treatment for hiv that impairs the virus's ability to multiply. when used properly, it has been shown to be successful in reducing hiv-related deaths. a high adherence rate to art is required to adequately suppress the virus, limit drug resistance, and reduce transmission. hiv infected people who are depressed often experience increased difficulty with adhering to their art regimen. this study will compare the effectiveness of a cognitive behavioral intervention that targets both depression and adherence versus usual care practices which may or may not include mental health intervention with the goal of improving art adherence among hiv infected adults with depression who are experiencing difficulty with adhering to their medication regimen. this study will last 24 weeks. participants will be randomly assigned to receive the cognitive behavioral intervention or usual care. study visits for all participants will occur at baseline and weeks 4, 8, 16, and 24. those receiving the intervention will also have visits at weeks 1 and 2. participants receiving the intervention will attend five individual treatment sessions followed by one to three booster treatment sessions; these sessions will coincide with the study visits.

Eligibility criteria:
inclusion criteria: * reports significant depressive symptoms as indicated by score of 10 or greater on phq-9 * currently taking art for hiv infection * less than 90% adherence rate to art regimen * capable of walking and in stable health * speaks fluent english exclusion criteria: * depression therapy is needed immediately * meets criteria for current drug dependency * current diagnosis of psychotic disorder or bipolar depression

Keywords: antiretroviral adherence poor antiretroviral adherence
a post-market clinical follow up of the genio™ system for the treatment of obstructive sleep apnea in adults

Conditions: Obstructive Sleep Apnea

Summary: the primary objective of this study is to confirm the safety and clinical effectiveness of the genio™ system, used according to its instructions for use, in moderate to severe obstructive sleep apnea (osa) adult patients over a period of 3 years post-surgery.

this study is a multicenter, prospective single arm pmcf. following activation of the genio™ system between 6 to 10 weeks post-surgery, patients will be followed at 3 months, 6 months, 9 months, 12 months and then every year for a total period of 5 years after surgery. phone calls follow-up will be performed at month 18, month 30, month 42 and month 54.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) \< 35 kg/m2 * ahi between 15 to 65 events/hour documented by a psg during the screening phase. * has either not tolerated, has failed or refused positive airway pressure (pap) or mandibular advancement device (mad) treatments. exclusion criteria: * night shift worker * significant comorbidities that contraindicates surgery * life expectancy \< 12 months * participation in another clinical study (excluding registries) during the study period (3 years).