Kornimate/medical-research-clean huggingface dataset:
chatbot-based positive psychology intervention in caregivers of children with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: this project aims to evaluate the feasibility and preliminary effectiveness of chatbot-based positive psychology intervention.

according to a world health organization report, one in 100 children is diagnosed with autism spectrum disorder (asd), which is characterized by varying degrees of disability and deviation in social communication and interaction. half of the parents of children with asd have reported showing depression and high levels of anxiety. lower well-being and poor quality-of-life have also been reported. thus, there is an urgent need to find applicable interventions to reduce depressive symptoms and promote mental health in caregivers of children with asd. positive psychology intervention uses positive psychological skills, such as savoring, gratitude, forgiveness, optimism, personal strength, and attainable goals, to identify meaning and value in life events and to promote positive emotions, cognitions and behaviors. considering the convenience, low cost and popularity of chatbot, chatbot-based positive psychology intervention will be applied in this study. a pilot feasibility study will be proposed to evaluate the feasibility of chatbot-based positive psychology intervention. the primary objective is to evaluate the feasibility and preliminary effectiveness of chatbot-based positive psychology intervention in promoting well-being in caregivers of children with asd (primary). the secondary objectives are: to test if the intervention reduces perceived stress in caregivers of children with asd; to test if the intervention reduces depressive symptoms of caregivers of children with asd; to test if the intervention improves quality of life in caregivers of children with asd.

Eligibility criteria:
inclusion criteria: primary caregivers * (i) providing long-term care for the primary-school-age child (6-11 years old) diagnosed with asd; * (ii) who are over 18 years old; * (iii) who have the ability to communicate and read in chinese; * (iv) who have at least one mobile phone with an internet connection. exclusion criteria: primary caregivers * (i) who participate in a similar psychological intervention within one year; * (ii) currently on regular psychotropic medications.
trauma informed prevention for substance use and risky sex

Conditions: Substance Use; HIV/AIDS

Summary: the purpose of this research study is to determine the usefulness of the tips ipad app in the treatment of adolescent patients who qualify for trauma focused-cognitive behavioral therapy (tf-cbt).

the primary goal of this study is to conduct a feasibility test of the delivery of the tips app during implementation of tf-cbt in comparison to tf-cbt as it is usually administered, as well as feasibility of methods that would be utilized in a larger scale evaluation of the toolkit. clients will be randomly assigned to one of the two conditions, tf-cbt plus the tips app or tf-cbt as usual. study duration is six months and includes four total assessments, which will be completed by hand. these assessments will occur over the 12-16 weeks of tf-cbt that clients would receive whether they choose to participate in the study or not. participation in this study may broaden your child's treatment to target prevention of risk behaviors, but that cannot be guaranteed.

Eligibility criteria:
inclusion criteria: * have experienced at least one traumatic event exclusion criteria: * adolescents exhibiting psychotic symptoms * significant cognitive disability * pdd * active suicidal or homicidal ideations * meets criteria for a dsm-5 moderate or severe substance use disorder

Keywords: traumatic stress substance use prevention hiv prevention adolescents
safety and effectiveness evaluation of cobra pzf coronary stent system: a post marketing observational registry

Conditions: Stable Angina; Unstable Angina; ACS - Acute Coronary Syndrome; STEMI; NSTEMI - Non-ST Segment Elevation MI; Myocardial Infarction

Summary: a multi-center, prospective, consecutive enrolled, observational registry. the population being studied includes all patients undergoing treatment of "de novo" lesions in native coronary vessels, saphenous vein graft and/or arterial bypass conduits with the cobra pzf coronary stent system. the registry will primarily assess the rate of mace (cardiac death, myocardial infarction and clinically driven target lesion revascularization.


Eligibility criteria:
inclusion criteria: patient has given oral consent to participate in the registry patient is implanted with a cobra pzf stent target lesion(s) is/are "de novo" exclusion criteria: pregnancy age \<18 years refusal or inability to give oral consent
testicular adrenal rest tumor in congenital adrenal hyperplasia patients attending assuit university children hospital

Conditions: Testicular Adrenal Rest Tumor; Congenital Adrenal Hyperplasia

Summary: assessment of the risk factors contributing for tart development in a male child with congenital adrenal hyperplasia.

congenital adrenal hyperplasia (cah) is one of the most frequent endocrine disorders. it is characterized by deficient activity of one of the enzymes necessary for adrenal cortisol synthesis. autosomal recessive inheritance of deficient 21-hydroxylase (21 oh) activity accounts for more than 90% of cases. \[1\] one of the most important and frequently detected complications in males with congenital adrenal hyperplasia (cah) is the development of testicular adrenal rest tumours (tarts). . \[2\],\[3\] testicular adrenal rest tumor is a benign tumor originating from adrenal cells within the testicles; the adrenal cells migrate at 8 weeks of gestation from the urogenital ridge along with the gonadal cells to the testicle. the exact mechanism underlying tumor growth and development is still not well understood . \[4\],\[5\] the correct diagnosis of tart is important for differential diagnosis with malignant testis tumors, which need orchiectomy, as opposed to tart, usually treated exclusively with exogenous steroids. \[6\]. although tarts are always benign, their location in the rete testis could obstructs the seminiferous tubules and causes gonadal dysfunction and infertility. therefore, it is important to detect and treat tarts at an early stage, especially in adolescents or young adults. \[5\],\[7\] testicular ultrasound should be done in order to evaluate the presence of these lesions, its size, location, and characteristics. \[9\] tarts in children have mostly been presented as case reports in the literature, and only a limited number of studies have described the prevalence of tarts in large populations of children . \[2\],\[8\] as not all male cah patients are affected by this complication, attempts have been made to identify the risk factors for the development of tarts . \[7\]

Eligibility criteria:
inclusion criteria: * all male patients diagnosed as congenital adrenal hyperplasia based on clinical manifestations and laboratory investigations from age of 4 years to age of 18 years. exclusion criteria: * patients with other adrenal insufficiency cause and congenital adrenal hyperplasia that progressed to true precocious puberty
ghnnam excision technique for pilonidal sinus

Conditions: Pilonidal Sinus; Surgical Wound; Dressing by Cyanoacrylate

Summary: pilonidal disease is a common disorder of the sacrococcygeal region. it comprises a variety of problems, including infection/abscess and the development of a chronic sinus cavity.here we try a minimmally invasive method for managing such condition

pilonidal disease is a common disorder of the sacrococcygeal region. it comprises a variety of problems, including infection/abscess and the development of a chronic sinus cavity. incidence varies across countries and races .the cause remains controversial. both congenital and acquired causes have been postulated excision with a simple lay-open or performing marsupialization both result in a midline wound that takes several weeks to heal and there is a significant recurrence rate because of the open portal for hair insertion.so here we apply a new minimally invasive excision with cyanoacrylate dressing

Eligibility criteria:
inclusion criteria: * any patient with pilonidal sinus exclusion criteria: * pilonidal abscess or sever acute inflammation

Keywords: pilonidal disease excision cyanoacrylate
prevalence of malnutrition and/or sarcopenia at hospital admission

Conditions: Malnutrition; Sarcopenia

Summary: the purpose of this study is to determine the prevalence of malnutrition and/or sarcopenia at admission to the hospital in older adults.

the primary outcome of this study is to determine the prevalence of malnutrition and/or sarcopenia at admission to the hospital in older adults. the secondary outcome is to assess the relationship between malnutrition/sarcopenia status and length of stay, comorbidity load, polypharmacy, and 30-day readmission.

Eligibility criteria:
inclusion criteria: * admitted to the utmb ace unit * aged 65 years or older * able to consent to participate in study (alert and oriented x3) exclusion criteria: * because this study aims to determine prevalence of malnutrition and/or sarcopenia at admission to the hospital, patients will be excluded if study measures are not able to be taken within 72 hours of admission.
outcome, recuperation and hemodynamics in aortic stenosis

Conditions: Aortic Valve Stenosis

Summary: indication for aortic valve replacement (avr) in aortic stenosis (as) is currently based on the classical triad of clinical as symptoms, estimation of as severity, and cardiac repercussion at rest. however, presence of symptoms in elderly is often subjective and underreported, and cardiac function analysis at rest underestimates the true impact of the chronic afterload increase. this complicates the diagnosis and hampers timely aortic valve replacement therapy with an impact on prognosis and cardiac function recovery. exercise imaging in as may reveal underlying cardiac repercussion and symptoms at an earlier stage and therefore impact prognosis and cardiac function recovery after avr. therefore the principal objective of this study is to reveal the factors that determine clinical outcome and hemodynamic function recovery after avr in as.


Eligibility criteria:
inclusion criteria: * every patient above 18 years of age with an echocardiographic established moderate to severe as * a guideline indication for aortic valve replacement therapy exclusion criteria: * unable to perform exercise testing * previous aortic valve intervention * more than moderate other valvular disease * patients refusing participation or unwilling to sign the informed consent
enteric oxalate absorption study in unclassified hyperoxaluria

Conditions: Enteric Hyperoxaluria; Hyperoxaluria

Summary: the purpose of this study is to learn more about a condition called 'unclassified hyperoxaluria'. people with this condition have large amounts of oxalate in their urine, which can cause kidney stones and kidney failure. we do not know what causes the high level of oxalate in the urine. in this study, we will evaluate absorption of a test dose of oxalate taken orally by measuring the amount of the test dose that is eliminated in the urine. we will compare the results of affected patients to healthy volunteers.

participants' oxalate intake and output will be monitored and assessed over a 24 hour period. participants will ingest a prescribed oxalate dose and urine oxalate will be monitored for the 24 hour study period.

Eligibility criteria:
inclusion criteria: * age equal to or greater than 4 years (patient must be able to void on request). * have good health. exclusion criteria: * any prior history of renal disease, or hypertension * all subjects (controls and affected patients) will be asked to discontinue any diuretics, calcium supplements, h2 blockers, proton pump inhibitors or gastrointestinal motility agents for approximately one week prior to initiation of the study. * subjects with gfr \< 50 cc/min will be excluded.

Keywords: hyperoxaluria unknown hyperoxaluria enteric hyperoxaluria oxaluric high oxalate oxalate c13 oxalate diet
assessment of the neurovascular microcirculatory response in diabetes type 1 patients

Conditions: Diabetes Mellitus Type 1

Summary: this study aims to see whether or not the diabetes 1 patients have a neurovascular microcirculatory dysfunction using various microvascular tests which have been previously validated. microvascular responses will be assessed by laser speckle contrast imaging and expressed in laser speckle perfusion units (lspu).

the investigators will compare microvascular responses between diabetes type 1 patients with matched control-subjects.

Eligibility criteria:
inclusion criteria: * diabetes type 1 patients * matched control-subjects exclusion criteria: * patients or subjects with anti-inflammatory drugs
eecentric exercise on cardiopulmonary fitness and quality of life with chronic obstructive pulmonary disease

Conditions: COPD (Chronic Obstructive Pulmonary Disease)

Summary: this study aims to investigate the effects of elliptical exercise on the six-minute walk test and quality of life in patients with chronic obstructive pulmonary disease (copd) to identify the most efficient exercise training method.

background： chronic respiratory diseases, including copd, are leading causes of chronic illness and mortality worldwide. however, limitations in ventilation and muscle function restrict copd patients from engaging in higher-power exercise therapies. compared to concentric exercise, eccentric exercise can effectively improve health-related fitness and quality of life at lower cardiopulmonary and metabolic loads. pulmonary rehabilitation programs have been shown to effectively improve symptoms of chronic respiratory diseases, increase exercise capacity, enhance quality of life, delay disease progression, prevent and treat acute exacerbations, and reduce mortality. therefore, it is hoped that a "safe and effective" eccentric exercise strategy can be designed for copd patients to comprehensively improve their cardiopulmonary/muscle fitness and quality of life, thereby improving the course of their disease. study design： this is a one-year, single-center, prospective randomized controlled trial. methods： this study plans to enroll 60 participants who will be randomly assigned to control and experimental groups. the intervention will take place in the pulmonary rehabilitation room on the sixth floor of fu jen hospital. each group will undergo a functional fitness test and complete a quality of life questionnaire before and after 24 sessions (over 12 weeks) of exercise training. effect： it is anticipated that after 24 sessions of elliptical exercise training, there will be an improvement in the functional fitness and in quality of life related to physical activity function. key words： pulmonary rehabilitation; eccentric exercise; chronic obstructive pulmonary disease; cardiopulmonary fitness; functional fitness

Eligibility criteria:
inclusion criteria: * having undergone pulmonary rehabilitation for more than 3 months * sign the written informed consent form * fev1/fvc \< 0.70 * approval for exercise training granted by a specialist physician's assessment * specialist physician's approval for exercise training exclusion criteria: * existing of tracheostomy * those who use oxygen therapy or ventilator at home * severe heart failure (nyha iii-iv) * neuromuscular disease * acute exacerbation within the past three months * those who are unable to cooperate with the cardiopulmonary exercise test

Keywords: pulmonary rehabilitation eccentric exercise chronic obstructive pulmonary disease cardiopulmonary fitness functional fitness
comparative study of ologen collagen matrix versus mitomycin-c in trabeculectomy: a study in germany

Conditions: Open-angle Glaucoma

Summary: the aim of this prospective randomized study is to investigate the efficacy and safety of trabeculectomy with ologen collagen matrix versus trabeculectomy using mitomycin c (mmc) in patients with medically uncontrolled open angle glaucoma.

ologen® collagen matrix (cm) is an artificial extracellular matrix (ecm) specifically configured to support repair in connective and epithelial ocular tissue. the device is constructed so as to minimize random growth of fibroblasts and instead to allow them to grow through the pores in the matrix. ologen® cm is a biodegradable scaffold matrix, inducing a regenerative non-scarring wound healing process without using anti-fibrotic agents. for application in glaucoma filtration surgery, ologen® cm is designed to prevent scar formation (subconjunctival and scleral flap scarring is the major risk factor for failure of trabeculectomy). after implanting the ologen® cm on top of the scleral flap in the subconjunctival space, a functional bleb can be created. the aim of the present study is to determine the effectiveness of the ologen® cm and reduce wound scarring, thereby increasing success of trabeculectomy without side effects of mmc. a means of producing better success rate and reduced complications is the purpose of ologen® collagen matrix for the aid of glaucoma surgery.

Eligibility criteria:
inclusion criteria: * age 18 years or over * uncontrolled open-angle glaucoma * subject is willing to sign informed consent * subject is able and willing to complete post-operative follow-up requirements exclusion criteria: * inflammatory eye diseases * angle-closure glaucoma * secondary glaucoma with anatomical malformations of the eye * subjects having single functional eye * previous conjunctival surgery * known allergic reactions to ingredients of ologen collagen matrix * excessive myopia (axial length (al)\> 27 mm or more than -10 diopters) * previous vitrectomy eye surgery * subjects do not consent to participate

Keywords: ologen mitomycin-c collagen matrix trabeculectomy glaucoma filtering surgery
a study to evaluate the safety and effectiveness of a nasal spray to treat perennial allergies

Conditions: Perennial Allergic Rhinitis

Summary: the purpose of this study is to determine if two allergy medications are more effective than placebo.


Eligibility criteria:
inclusion criteria: * male and female patients 12 years of age and older * must be in generally good health * must meet minimum symptom requirements, as specified in protocol * must be willing and able to provide informed consent and participate in all study procedures * 2-year history of par * positive skin test to cockroach, dust mite, mold or cat/dog dander exclusion criteria: * on nasal examination, presence of any nasal mucosal erosion, nasal ulceration or nasal septal perforation at the screening or randomization visit * nasal diseases likely to affect deposition of intranasal medication, such as sinusitis, rhinitis medicamentosa, significant polyposis or nasal structural abnormalities * nasal surgery or sinus surgery within the previous year * the use of any investigational drug within 30 days * presence of any hypersensitivity to drugs similar to azelastine and to either sorbitol or sucralose * women who are pregnant or nursing * women of child-bearing potential who are not abstinent and not practicing a medically acceptable method of contraception * respiratory tract infection within 2 weeks of screening * respiratory tract infections requiring oral antibiotic treatment within 2 weeks of screening * patients with asthma with the exception of mild, intermittent * significant pulmonary disease including copd * patients with arrhythmia * patients with a known history of alcohol or drug abuse * existence of any surgical or medical condition, which in the opinion of the investigator or sponsor may significantly alter the absorption, distribution, metabolism or excretion of study drug. * clinically relevant abnormal physical findings within one week of randomization * overnight abscences from home for more than 3 nights * employees of the research center or private practice and family members are excluded * patients who received prohibited medications within specified timepoints in protocol.
the segmental distribution of hypersensitivity in patients with chronic subacromial pain syndrome

Conditions: Subacromial Pain Syndrome; Central Sensitisation

Summary: this study aimed to determine the distribution of pain sensitivity according to body segments in patients with central sensitization associated with chronic subacromial pain syndrome (sps).this cross-sectional study included patients with chronic sps and central sensitization (patient group) and the same number of healthy participants as controls. the presence of central sensitization was determined using the central sensitization inventory. to determine the segmental distribution of pain sensitivity, pressure pain threshold measurements were performed bilaterally from the shoulder, forearm, and leg.

shoulder pain is a common musculoskeletal pain condition in the general population, with a prevalence that has doubled in all age groups over the past 40 years, reaching 22%-30%. despite treatment, at least 40% of patients report incomplete improvement in pain severity and duration of symptoms, which are the two main determinants of treatment response. there is convincing evidence that the persistence of pain in these patients is due to peripheral or central sensitization mechanisms. central sensitization refers to pain hypersensitivity mainly resulting from amplifying central nervous system signals and reduced activity of central inhibitory pathways. the clinical presence of central sensitization is determined by examining specific pain characteristics or evaluating changes in pain threshold. the objective manifestation of central sensitization is a decreased pressure-pain threshold (ppt) (hypersensitivity). in previous studies using ppt measurement, pain sensitivity was detected in the shoulder and remote joints in patients with subacromial pain syndrome (sps), which was considered as evidence of central sensitization. however, these studies did not show how pain sensitivity differs according to body segment in patients with sps. hypersensitivity that develops due to chronic shoulder pain would exacerbate the perception of pain caused by other musculoskeletal diseases or trauma. therefore, it may be important for clinicians to determine how pain sensitivity varies by body segment in patients with sps

Eligibility criteria:
inclusion criteria: * to be diagnosed with chronic (≥ 3 months) unilateral sps according to clinical examination (the hawkins-kennedy test and the painful arc test) and/or imaging. * to be scored ≥ 40 on csi exclusion criteria: i) bilateral shoulder pain syndrome, ii) history ofshoulder surgery, iii) osteoarthritis of the glenohumeral joint on direct radiography, v)concomitant diseases with the potential risk of development of central/peripheral sensitization \[diseases specified in csi part b, vi) symptomatic lateral/central spinal stenosis, myelopathy, or radiculopathy, vii) history of centrally acting drug use (e.g.,pregabalin, gabapentin, amitriptyline, duloxetine, and opioid) viii) alcohol/substance abuse.

Keywords: shoulder pain hypersensitivity pressure pain threshold