Kornimate/medical-research-clean huggingface dataset:
association of scnn1a single nucleotide polymorphisms with neonatal respiratory distress syndrome

Conditions: Neonatal Respiratory Distress Syndrome

Summary: lung fluid absorption disorders are largely mediated by transepithelial na+ reabsorption through alpha epithelial sodium channels (α-enacs) in alveolar epithelial cells. increasing evidence has demonstrated that these lung disorders might be an important cause of neonatal respiratory distress syndrome (nrds) by influencing gas exchange or surfactant function, particularly in near-term and term infants. the scnn1a gene, which encodes the α-enac, might predispose infants to nrds. to explore whether the single-nucleotide polymorphisms (snps) of scnn1a are associated with nrds, we conducted a case-control study to investigate the nrds-associated loci in han chinese infants. seven target snps were selected from the scnn1a gene and were genotyped using the improved multiplex ligase detection reaction (imldr).


Eligibility criteria:
inclusion criteria: * newborns with rds exclusion criteria: * the infants were excluded if they had any congenital malformation, inherited metabolic abnormalities, intrauterine infection, rh/rh incompatibility, pneumonia, pulmonary hypertension, meconium aspiration syndrome, or asphyxia

Keywords: lung fluid absorption disorders neonatal respiratory distress syndrome single nucleotide polymorphism scnn1a
retrospective analysis of results of surgery for deep bowel endometriosis

Conditions: Endometriosis; Deep Endometriosis; Bowel Endometriosis; Reproductive Issues; Complication

Summary: identification of patients operated becaus of bowel endometriosis at the endometriosis center, university hospital muenster, germany, starting 2009, analysis of patient history, surgical procedurie, intraoperative complications, postoperative complications, phone call assessing further complications, complaints after surgery, pregnancy, live birth, additional surgery, spontaneous conception, conception by iui, art


Eligibility criteria:
inclusion criteria: * deep infiltrating endometriosis, surgery with complete or partial resection of bowel endometriosis or conservative management, treatment at endometriosis center university hospital muenster, germany, wants to participate exclusion criteria: * declines participation

Keywords: endometriosis deep endometriosis bowel endometriosis conception art spontaneous conception pregnancy rate
a multi-center study evaluating the safety of ac-170 0.24%

Conditions: Atopic Disease (Including Allergic Conjunctivitis)

Summary: the purpose of this study is to evaluate the safety of ac-170 0.24% used twice daily in healthy adult subjects and in pediatric subjects with a history or family history of atopic disease (including allergic conjunctivitis).


Eligibility criteria:
inclusion criteria: * at least 2 years of age * be able to self-administer eye drops or have a parent/legal guardian available for this purpose * if less than 18 years old have a history or family history of atopic disease (including allergic conjunctivitis) * have ocular health within normal limits exclusion criteria: * known contraindications or sensitivities to the study medication or its components * any ocular condition that, in the opinion of the investigator, could affect the subjects safety trial parameters * use of disallowed medication during the period indicated prior to the enrollment or during the study
drug interaction study of an ocp (norethindrone (nd) acetate and ethinyl estradiol (ee))with a combination of daclatasvir (dcv) asunaprevir (asv) and bms-791325

Conditions: Hepatitis C

Summary: the purpose of this study is to assess the effect of dcv/asv/bms-791325 fixed dose combination (fdc) + 75mg bms-791325 on the pharmacokinetics (pk) of the oral contraceptive agent.

ind number: 79,599 and 101,943 other: phase 1 clinical pharmacology drug interaction study in healthy female subjects

Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * healthy females within age of 18-40 years * must be a women of childbearing potential * must be on a stable regimen of oral contraceptive therapy for at least 3 consecutive months prior to study start exclusion criteria: * subjects must not have any significant acute or chronic medical illnesses or conditions precluding safe use of oral contraceptives * prior exposure to dcv, asv or bms-791325 within 30 days of dosing on study day 1 * smoking within 6 months of study start
combined ribavirin with sofosbuvir/velpatasvir/voxilaprevir in retreatment of chronic hepatitis c non-responders

Conditions: Chronic Hepatitis C

Summary: this study aims to assess the role of ribavirin as an adjuvant to sofosbuvir/velpatasvir/voxilaprevir combination in retreatment of chronic hepatitis c with previous treatment failure.


Eligibility criteria:
inclusion criteria: * adult (≥ 18 years) patients with chronic hepatitis c and detectable hcv rna by polymerase chain reaction (pcr) after completion of previous direct-acting antiviral regimen, and eligible for antiviral treatment. exclusion criteria: * patients with decompensated cirrhosis (child-pugh score b and c). * patients with platelet count less than 50000/ mm³. * patients with hcc or extrahepatic malignancy. * pregnancy or inability to use an effective contraceptive method.

Keywords: hcv relapse treatment failure
study of notes-tme versus l-lar in rectal cancer

Conditions: Rectal Cancer

Summary: introduction: transanal tme (t-tme) combined with laparoscopy, called hybrid-notes, is a less invasive procedure that responds to some of the limitations of the rectal laparoscopic approach. main objective: to analyze that the t-tme gets a faster recovery due to a lower conversion rate to open surgery than laparoscopic low anterior resection (l-lar) in rectal cancer with the same pathological, functional and oncologic results. methodology: a prospective multicenter randomized controlled study of patients with rectal cancer that, were randomized in the t-tme- and l-lar group. the main variables are: general morbidity, anastomotic dehiscence, conversion rate to open surgery and hospital stay. the sample calculation is 58 patients per group.

introduction: the laparoscopic total mesorectal excision (tme) has provided better patient recovery with less morbidity and shorter hospital stay compared with open surgery. however in laparoscopic low rectal surgery, overall conversion to open surgery is around 20%. transanal tme (t-tme) combined with laparoscopy, called hybrid-notes, is a less invasive procedure that responds to some of the limitations of the rectal laparoscopic approach. main objective: to analyze that the t-tme gets a faster recovery due to a lower conversion rate to open surgery than laparoscopic low anterior resection (l-lar) in rectal cancer with the same pathological, functional and oncologic results. methodology: a prospective multicenter randomized controlled study of patients diagnosed with adenocarcinoma of the rectum that after inclusion and exclusion criteria, were randomized in the t-tme- and l-lar group. the main variables are: general morbidity, anastomotic dehiscence, conversion rate to open surgery and hospital stay. the other variables studied were: demographic, surgical, pathological, 30-day morbidity and mortality, quality of life and oncologic results. the sample calculation is 53 patients per group. with an estimated loss of 10%, the final number will be 116 patients.

Eligibility criteria:
inclusion criteria: * age over 18 years * patients with rectal cancer stage: ct1-2-3, cn0-1, cm0. * tumor equal or below 10 cm from the anal verge, candidates to (etm) low anterior resection and anastomosis, with or without preoperative chemo-radiotherapy. * adenocarcinoma of low or moderate differentiation * asa i, ii, iii. exclusion criteria: * do not sign informed consent * pregnant patients * liver cirrhosis * undifferentiated adenocarcinoma. * ct4 * metastatic disease (m1) * chronic renal failure on dialysis * asa iv * bmi \ 35 kg / m2

Keywords: transanal notes transanal tme laparoscopic low anterior resection surgery
intramedullary devices for the treatment of unstable pertrochanteric fractures

Conditions: Fractures

Summary: the purpose of this study is to assess the differences between two different types of devices for the treatment of unstable pertrochanteric hip fractures. the hypothesis of this study is, that patients who are treated with the proximal femoral nail antirotation (pfna) have a better outcome and lower complication rates than patients treated with the gamma nail (gn3).

this trial is a prospective randomized controlled study including the treatment of ao/ota 31-a2 fractures in 200 patients with 2 different surgical devices. 100 patients are treated with a gamma nail 3 (gn3) (stryker) the other 100 patients with a proximal femoral nail antirotation (pfna) (synthes). all surgeries are performed by trauma surgeons at a level 1 university hospital. one hundred patients are randomized to the gamma nail and 100 are randomized to the proximal femoral nail for treatment fixation. a 1:1 randomization is performed using sealed envelopes (200 in total), which are opened by the surgeon immediately before the operation. patients missing an informed consent form, incomplete chart, or showing a pathologic fracture are getting excluded from final comparisons. patients anthropometric data as well as pre-injury mobility assessments, and asa will be documented. furthermore the time from admission to going to surgery, surgery length, length of stay and mobility assessment at dischargement are recorded. after surgery the stay in the hospital is documented precisely and patients are scheduled for next appointments 2 weeks, 6 weeks, 3 months, 6 months and 1 year after surgery. postoperative x-rays are measured precisely to determine the tip-apex distance (tad), the parkers-ratio, the singh-score and the neck-shaft-angle of the injured and contralateral side. rates of complications as cut-out and reoperation-rates are evaluated. all intra-operative complications are noted and included in the chart.

Eligibility criteria:
inclusion criteria: * ao/ota 31-a2 fractures * age between 18 - 100 years * signed written informed consent and agreement to attend the planned fus * able to understand and read country national language at an elementary level exclusion criteria: * missing informed consent form * pathological fracture * incomplete patient record * death within one month of intervention (surgery) * prior surgery to the hip * polytrauma * any additional fracture * any implant at the same hip * infection

Keywords: re-operation rate pertrochanteric fractures gammanail pfna tip-apex-distance parkers-ratio
gingival response and marginal adaptation of zirconia crowns with two subgingival margin designs

Conditions: Gingival Recession, Localized

Summary: the aim of the study is to evaluate the effect of feather edge finish line and deep chamfer finish line on gingival position, bleeding on probing and marginal adaptation.

the aim of the study is to evaluate the effect of feather edge finish line and deep chamfer finish line on gingival position, bleeding on probing and marginal adaptation. gingival bleeding on probing will be evaluated before treatment. preparation for all ceramic full coverage restoration will be performed according to manufacturer instructions by one operator. type of finish line (whether feather edge or deep chamfer finish line) will be selected randomly according to a computer generated randomization list. restorative margins will be placed subgingivally. zirconia crowns will be fabricated for the prepared teeth and cemented using resin luting agent. at 6 months and 12 months after the cementation, restorative margin position relative to the gingival margin will be recorded. bleeding on probing and marginal adaptation will also be recorded.

Eligibility criteria:
inclusion criteria: * patients 18 years to 50 years old * dentate patients planned for a single full coverage restoration in the posterior area. * patients with no active periodontal disease. * \>2mm of keratinized tissue exclusion criteria: * smoking (\>10 cigarettes a day) * substance abuse history * patients with poor oral hygiene and high caries index * patients suffering from abnormal occlusal habits for example clenching or bruxism * local or systemic disease (endocrine, renal, hematologic, hepatic, immunosuppressive) * current steroid/chemotherapy * head and neck irradiation * pregnancy * inability or unwillingness to return for follow up visits.
upper limb cross-education in subacute stroke

Conditions: Hemiplegia; Stroke

Summary: this study evaluates how cross-education (unilateral training) affects muscle strength of the paretic limb in acute stroke patients. half of the hemiplegic patients will receive conventional treatment and transcutaneous electrical nerve stimulation (tens) to non-paretic side, while other half will receive conventional treatment and electro muscular stimulation (ems) to non-paretic side.

cross-education, which means the performance improvement in the untrained homologous muscle after unilateral exercise training, is studied in various orthopedical and neurological conditions affecting the body unilaterally. for those with asymmetrical weakness and immobility after stroke, training the non-paretic side can be utilized to increase the strength of the paretic side and improve functional symmetry. in this study, investigators aim was to examine whether training non-paretic upper extremity wrist flexor muscles by ems in adjunct to conventional training program, has additional benefits upon the muscle powers of the homologous agonist and antagonist muscles. investigators will use low frequency antalgic tens stimulation at barely sensible level, which is considered not to cause muscle strengthening, as a control intervention.

Eligibility criteria:
inclusion criteria: * thromboembolic stroke, * \<6 months of stroke, * right hand dominancy, * left hemiplegia, * brunnstrom stage ≥ 3 of recovery for upper extremity and hand exclusion criteria: * myopathy, tendinopathy, peripheral neuropathy of the upper extremities, * auditory, cognitive or speech disorder that enables communication, * history of fracture or arthrodesis in the upper limb, * contracture or severe spasticity (ashworth scale ≥ 2) in forearm muscles, * severe cardiovascular disorders (heart failure, coronary artery disease, drug resistant hypertension)

Keywords: cross-education interlimb transfer electro muscular stimulation muscle strength
effect of tdcs on inflammatory biomarkers in chronic schizophrenia

Conditions: Chronic Schizophrenia

Summary: the study is a randomized, double-blind, parallel-arm, sham-controlled trial that aims to compare the effects of transcranial direct current stimulation (tdcs) versus sham stimulation on inflammatory markers (il-6 and tnf-alpha) and clinical outcomes (panss, ahrs, cgi-sch, gaf) in patients with chronic schizophrenia over 10 days of treatment. the primary objective is to assess changes in il-6 levels, while secondary objectives include evaluating changes in tnf-alpha, symptom scales, and adverse events. the study will be conducted at the psychiatry department of aiims bhubaneswar, with 60 patients aged 18-60 years with moderate-to-severe schizophrenia symptoms randomized to receive either active tdcs (cathode over left temporo-parietal junction, anode over left dorsolateral prefrontal cortex) or sham stimulation. the researchers hope to elucidate the potential immunomodulatory effects of tdcs and its impact on symptoms in chronic schizophrenia, which may lead to more targeted, multifaceted interventions to improve patient outcomes.


Eligibility criteria:
inclusion criteria: - 1. patients clinically diagnosed with schizophrenia (f20 according to icd-11) for a period more than 2 years receiving antipsychotics. 2. moderate to severe symptoms (panss score \>75 and/or cgi-sgh score \>4) 3. patients of both sex 18-60 years 4. right-handed. 5. legally authorized representative (lar) giving voluntary written consent for participation in the study. exclusion criteria: * 1. patients with chance of pregnancy. 2. any psychiatric emergency (e.g. suicidal risk, catatonia, prolonged nutritional deprivation) or others (e.g.: aggression or excitement) 3. co-morbid neurological disease: i) history of migraine. ii) history of seizure/epilepsy. iii) history of head trauma or organic disease. 4. any contraindication to tdcs procedure: i) injury or local lesion in the scalp/head ii) metallic implants in the head iii) implanted brain medical devices 5. left-handed.
development and testing of nutritional algorithms (nacho)

Conditions: Nutrition Poor; Nutritional Deficiency; Quality of Life

Summary: the goal of this research study is to develop a nutrition algorithm to optimize nutritional status and improve quality of life during for participants who are completing or have completed cancer treatment. the name of the intervention used in this research study is: nutrition algorithm for cancer health outcomes (nacho) (a technology-based platform that houses the algorithms for the person-centered nutrition program)

this is a longitudinal, mixed-methods, pilot descriptive study to develop a nutrition algorithm for cancer patients based on the cancer nutrition consortium (cnc) study findings and refined through a dietitian panel participants and from feedback from participants and family advisory council (pfac) members. research study procedures include screening for eligibility, interviews and/or focus groups, dietitian panel meetings, and surveys. participation in this study is expected to last about 12 months. it is expected about 130 people will participate in this research study.

Eligibility criteria:
inclusion criteria for dietitians/oncology clinicians - have worked with at least 3 patients at the study site who had nutritional challenges inclusion criteria for patient and family advisory council (pfac) participants * current member of adult pfac * \> 18 years old inclusion criteria for patient participants * \> 18 years old * able to speak and read english * completed primary treatment (aim 2b) or actively undergoing treatment (aim 2b and aim 3, exploratory) * access to a device (e.g., computer, tablet, smartphone) through which they can receive and engage with a redcap link exclusion criteria for patient participants • provider does not recommend

Keywords: poor nutrition nutritional deficiency quality of life
corneal epithelial autograft with middle lamellar keratoplasty for severe ocular burns

Conditions: Ocular Burns

Summary: the purpose of this pilot study is to explore whether corneal epithelial autograft (ea) combined with allogeneic middle lamellar keratoplasty (amlk) is more effective than limbal autograft (la) with amlk for ocular surface reconstruction in patients with severe ocular burns.


Eligibility criteria:
inclusion criteria: 1. unilateral severe ocular burns with more than half limbal stem cells deficiency (lscd). the history of the disease is at least 12 months at the time of screening visit. 2. presence of superficial neo-vascularization affecting at least 2 cornea quadrants and involving central cornea. 3. informed consent signed by a patient or legal guardian, or having the ability to comply with study assessments for the full duration of the study. exclusion criteria: 1. lscd of mild degree, with less than 2 quadrants of neo-vessel invasion and without central cornea involvement. 2. lscd by ocular surface disorders other than ocular burns. 3. eyelids malposition. 4. the center corneal thickness\<450µm, the depth of corneal opacity\<150µm or the full corneal lamellar opacity. 5. high myopia with a spherical equivalent of -15.0 d or less. 6. corneal or ocular surface infection within 30 days prior to study entry. 7. ocular surface malignancy. 8. uncontrolled diabetes with most recent hga1c greater than 8.5%. 9. renal failure with creatinine clearance ≤ 25ml/min per 1.73 m2. 10. alanine aminotransferase \> 40iu/l, or aspartate aminotransferase \> 40iu/l. 11. platelet levels \ 450,000 per microliter. 12. hemoglobin \< 12.0 g/dl (male) or \< 11.0 g/dl (female); 13. prothrombin time \> 16s and activated partial thrombin time \> 35s in patients not accepting anticoagulant therapy; an international normalized ratio greater than 3 in patients accepting anticoagulant therapy. 14. pregnancy (positive test) or lactation. 15. participation in another simultaneous medical investigation or clinical trial. 16. severe cicatricial eye disease; conjunctival scarring with fornix shortening. 17. ocular comorbidities that affect the prognosis of transplantation, such as advanced glaucoma or retinal diseases. 18. severe dry eye disease as determined by schirmer's test \< 2mm at least in one eye. 19. any medical or social condition that in the judgment of the investigator would interfere with or serve as a contraindication to adherence to the study protocol or ability to give informed consent. 20. signs of current infection, including fever and treatment with antibiotics. 21. active immunological diseases. 22. history of anti-glaucoma surgeries.