Kornimate/medical-research-clean huggingface dataset:
the effects of soy isoflavones to improve the metabolism of glucose and lipids

Conditions: Type 2 Diabetes Mellitus

Summary: many studies showed that soy foods or soy isoflavones can lower the risk of cardiovascular disease (cvd), osteoporosis and some cancers, but few human studies assessed effects of purified isoflavone components (genistein and daidzein) on glucose metabolism. this double-blinded, randomized, placebo-controlled trial will examine the effects of purified genistein and daidzein on glucose metabolism in prediabetic or diabetic women. one hundred and eighty eligible women age 30-70 years(without any treatment of diabetic drugs) will be recruited and randomly allocated into the following three arms: placebo (10g isolated soy protein, isp); genistein (10g isp + 50mg genistein); daidzein (10g isp + 50mg daidzein) per day for 6 mo. fasting glucose, lipids, insulin, inflammation marks and post-load for glucose and insulin will be determined at 0, 3th, and 6th month. changes in these indices will be compared among the three groups.

subjects were chinese adult women, age 30-70 year, with an fg concentration ranging from 5.6 to 7.0 mmol/l or 2-h pg concentration ranging from 7.8-11.0 mmol/l or with newly diagnosed diabetes not requiring medication treatment according to a doctor's suggestion or participants did not willing to take medication themselves, and managed their diabetes just with a stable diet and exercise. women were excluded if they had a history of coronary heart disease, stoke, thyroid disease, severe liver, lung, or gastrointestinal tract diseases; were currently or in the past 8 weeks used hypoglycemic or lipid-lowering or weight-reduction agents; were occurrence of diabetic complications; use of hormone replacement therapy; allergy to soy;were long-term antibiotics users.

Eligibility criteria:
inclusion criteria: * chinese women aged 30-70 y * fasting glucose \>=5.6 mmol/l; post-load glucose \>=7.8 mmol/l exclusion criteria: * diabetes renal diseases * confirmed cvd, chronic liver,kidney diseases,thyroid disease * medications affecting glucose or lipid metabolism

Keywords: genistein daidzein impaired glucose regulation glucose metabolism lipids metabolism inflammation women
the impact of an instructional web-based healthcare app for relieving back pain from spinal compression fractures

Conditions: Back Pain Lower Back Chronic

Summary: with the expected rise of patients with osteoporosis-induced fractures, it has become increasingly urgent to design and use specialized health education materials aimed at easing pain and improving bodily functions

this study designed web-based dynamic pain relief instructions for women with spinal compression fractures. we collected patients' pain rating data the day before, one month after, and three months after providing the instructions.

Eligibility criteria:
inclusion criteria: * postmenopausal women exclusion criteria: * postmenopausal women
a study of gdc-0084 in patients with progressive or recurrent high-grade glioma

Conditions: Glioblastoma, Glioma

Summary: this open-label, multicenter, phase i, dose-escalating study will evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics and efficacy of gdc-0084 in patients with progressive or recurrent high-grade glioma. stage 1 is the dose escalation part of the study. stage 2, patients will receive gdc-0084 at a recommended dose for future studies.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * interval of at least 12 weeks from completion of adjuvant radiotherapy for gliomas to study entry * karnofsky performance status of \>/= 70 at screening * confirmed measurable disease per rano * adequate hematologic and organ function patients enrolled in stage 1: * histologically documented recurrent or progressive high-grade gliomas (who grade iii-iv) * prior treatment with at least one regimen for gliomas (radiotherapy with or without chemotherapy for grade iii gliomas and radiotherapy with chemotherapy for grade iv gliomas) and/or not considered to be a candidate for regimens known to provide clinical benefit patients enrolled in stage 2: * histologically documented recurrent or progressive glioblastoma (who grade iv gliomas) * prior treatment with one or two regimens for glioblastoma (with the initial regimen consisting of radiotherapy with chemotherapy) exclusion criteria: * treatment with anti-tumor therapy (approved or experimental) within 4 weeks prior to initiation of study drug * requirement for anticoagulants such as warfarin or any other warfarin-derivative anticoagulants; low-molecular-weight heparin is permitted * any contraindication to mri examination * evidence of grade \>/= 1 intracranial hemorrhage * active congestive heart failure or ventricular arrhythmia requiring medication * clinically significant history of liver disease, including viral or other hepatitis, current alcohol abuse or cirrhosis * unresolved toxicity from prior therapy with the exception of lymphopenia (for patients with prior temozolomide) and alopecia * pregnant or lactating women
erector spinae block in first rib resection: a monocentric before-after study

Conditions: Thoracic Surgery

Summary: first rib resection surgery for thoracic outlet syndrome is associated with an intense postoperative pain. it leads to significant consumption of nonsteroidal anti-inflammatory drugs and opioids, and hospitalization for several days. in our center, first rib resection surgery was usually performed under general anesthesia combined with diffuse local infiltration of the axillary fossa. erector spinae block is an interfascial block where a local anesthetic is injected between the erector spinae muscle and the transverse process, in order to obtain a multimetameric analgesia. it has now shown its efficacy and its safety in thoracic and abdominal surgeries by decreasing the morphine consumption and pain scores. since november 2018, this erector spinae block is systematically performed preoperatively for first rib resection in our center, in association with a general anesthesia. patient satisfaction seems important but remains to be assessed objectively. in a before-after study, our goal is to assess the impact of the use of erector spinae block on postoperative pain in the first rib resection surgery.


Eligibility criteria:
inclusion criteria: * first rib resection for thoracic outlet syndrome
postprandial gut hormone responses in patients with type 1 diabetes mellitus

Conditions: type1diabetes; Hunger; Obesity

Summary: the study will compare the postprandial responses to a test meal between subjects with type 1 diabetes and healthy control subjects, in terms of gut hormone levels, meal induced thermogenesis, hunger and satiety perception, as well as futher metabolic parameters.

aim of the study to compare the acute effect of the consumption of a test meal on satiety, gastrointestinal hormones' response, post-meal thermogenesis, and further metabolic parameters in lean patients with type 1 diabetes mellitus (t1dm), obese patients with t1dm, and healthy lean and obese controls. study subjects: four groups of participants will be recruited, consisting of 15 lean healthy subjects (bmi \<25 kg/m2), 15 obese healthy subjects, 15 lean patients with t1dm (bmi \<25 kg/m2), and 15 obese patients with t1dm (bmi ≥ 30kg/m2). groups will be matched for age and sex. healthy volunteers will be recruited from the community, and diabetic individuals from our diabetes clinic. eligibility criteria will include 18-65 years of age, no use of medications affecting appetite and stable weight (no fluctuations exceeding 5 kg the last 3 months. methods: demographic data and anthropometric measurements will be collected on the day of visit. fasting blood samples will be collected for measurement of plasma glucose, insulin, triglycerides, gip, glp-1, pyy (total), ghrelin (total). vas for hunger and satiety will be completed in the fasting state. participants will then consume a test meal of \~700 kcal consisting of protein and fat (no carbohydrates) within 10 minutes. blood samples will be drawn and vas scales completed postprandially at 30, 60, 90, 120, 150, 180 min. rmr measurements using indirect calorimetry will be performed in the fasting state, 1 hour and 3 hours postprandially to assess meal induced thermogenesis. postprandial responses for these parameters will be assessed as area under the curve (auc). patients with t1dm treated with basal- bolus insulin therapy will receive their regular basal insulin dose and patients on an insulin pump will be kept on their basal rate of insulin infusion. in case of fasting hyperglycemia, the session will be canceled. postrpandial glucose excursion will be treated with fast acting insulin.

Eligibility criteria:
inclusion criteria: * type 1 diabetes * bmi \>30 kg/m2 for the obese groups exclusion criteria: * diabetic neuropathy * malignancy
low-level laser acupuncture reduces postoperative pain and morphine-related side effects in patients with total knee arthroplasty:

Conditions: Low-level Laser Acupuncture in Patients With Total Knee Arthroplasty

Summary: total knee arthroplasty is a common and effective surgical procedure for patients with end-stage knee osteoarthritis, and wound pain is still a problem for many of the patients.

therefore, the purpose of this study was to apply low level laser therapy measured variables included postoperative pain intensity, patient-controlled analgesia requirements, side effects caused by morphine, knee stiffness and wound pain in the daily activities of patients undergoing total knee arthroplasty. data were collected between april 2018 and january 2019. eighty-two knee osteoarthritis patients receiving total knee arthroplasty were recruited from one hospital and randomly, equally assigned to the laser acupuncture or control group. the la group received the low-level laser therapy with 3 joules at each acupuncture point at hour 2, hour 6, hour 10, hour 24, hour 48, and hour 72 after surgery; whereas the control group received the same manner except for joule.

Eligibility criteria:
inclusion criteria: * age 60 years or older * american sociological association (asa) class i-iii * spinal anesthesia, consent to patient-controlled analgesia (pca) and peripheral nerve block (pnb) * return to the ward directly from the anesthesia recovery room. exclusion criteria: * cutaneous lesions at the application sites * use of taking immunosuppressive agents * received intra-articular steroid treatment * opiate dependence * sensitive to light * epilepsy * clinically significant cardiovascular diseases * cancer * systemic lupus erythematosus.

Keywords: acupuncture points, low-level laser, postoperative pain, total knee arthroplasty
the expression of the ionotropic glutamate receptors in colon of ibs

Conditions: Irritable Bowel Syndrome

Summary: the study aims to determine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (ibs) patients and evaluate the relationship between the ionotropic glutamate receptors and ibs symptoms.

ionotropic glutamate receptors participate in pain in nervous system. in this study,participants will examine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (ibs) patients and evaluate the relationship between the ionotropic glutamate receptors and ibs symptoms. participants may futher study the mechanism using cell experiment.

Eligibility criteria:
inclusion criteria: patients meeting ibs rome iii criteria. asymptomatic individuals for health surveillance or patients for follow up after polypectomy. exclusion criteria: patients with known cancers or abdominal surgery. alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass. patients who are unwilling to sign or give the informed consent form. patients with impaired cardiac, liver or renal function. patients with coagulopathy. patients with pregnancy or breastfeeding.

Keywords: ibs ionotropic glutamate receptors
amulet™ advance laa

Conditions: Atrial Fibrillation; Stroke; Bleeding

Summary: this is a prospective, multicenter, observational study intended to characterize real-world outcomes on the commercially available amulet device in the united states. over 600 subjects have been enrolled at 16 us clinical sites. subjects will be followed through 24 months in accordance with each site's standard care practices.

the advance laa study is intended to characterize real-world outcomes of patients receiving the commercially available amulet device in the united states. the amulet device is intended to reduce the risk of thrombus embolization from the left atrial appendage (laa) in patients who have nonvalvular atrial fibrillation (nvaf) and who are at increased risk for stroke and systemic embolism based on chads2 or cha2ds2-vasc scores, are suitable for short-term anticoagulation therapy, and have appropriate rationale to seek a non-pharmacologic alternative to oral anticoagulation, taking into consideration the safety and effectiveness of the device.

Eligibility criteria:
inclusion criteria: * intended for laao with the amulet device * at least 18 years of age * willing and capable of providing informed consent and participating in all testing associated with this clinical study exclusion criteria: * presence of other conditions that, in the investigator's opinion, could limit the subject's ability to participate in follow-up
the impact of physical activity on the postoperative symptoms, complications, and quality of life among lung cancer

Conditions: Lung Neoplasms

Summary: the purpose of this study is to examine the impact of physical activity on the postoperative symptoms, complication, and quality of life.

non-small cell lung cancer (nsclc) survivor is increasing as developing early diagnosis and perioperative management. despite multidisciplinary treatment, surgery is the primary treatment option for cure in nsclc. the patients with lung cancer who underwent surgery have limitation of pulmonary function and high risk of co-morbidities. perioperative physical activity has been shown to reduce symptoms and prevent complications, improve long term quality of life after surgery. but validated exercise regimen has not been established for lung cancer patients. therefore, evidence-based guideline focusing on lung cancer after surgery is needed.

Eligibility criteria:
inclusion criteria: * patients who are diagnosed with lung cancer * patients who are able to walk with ecog (eastern cooperative oncology group) performance status \< 1 * patients who understand the purpose of this study and provide the written informed consent exclusion criteria: * patients who have difficulty for walking * patients with history of other cancer in the last 3 years * patients with neoadjuvant chemotherapy and/or radiation therapy * patients who are diagnosed with recurrent lung cancer or multiple cancer * foreigner of patients from overseas who are not able regularly participate in this study
prediction of adhesion by sliding sign

Conditions: Adhesions Abdominal

Summary: sliding sign will be checked by ultrasonography by transabdominal and transvaginal route before operation of patients that had cesarean section three or more. during cesarean section adhesions will be evaluated and noted. the correlation and predictive values of adhesion and sliding sign will be defined in our study.

three or more cesarean section patients will be included in our study. in addition, inflammatory markers in complete blood count as neutrophil, lymphocyte, neutrophil/ lymphocyte ratio, pan immune inflammation value (piv) will be recorded.

Eligibility criteria:
inclusion criteria: * all three and above number of cesarean section patients exclusion criteria: placenta adhesion spectrum -

Keywords: adhesion cesarean section sliding sign
icancope with pain: usability and feasibility testing of a smartphone application to manage pain in youth with arthritis

Conditions: Juvenile Idiopathic Arthritis

Summary: this study will look at the use and impact of smartphone application (app) for adolescents with ongoing pain caused by their juvenile idiopathic arthritis (jia).the current project will include three studies. first, the investigators conducted usability sessions with adolescents with jia to refine the app so that it is usable, acceptable and understandable. the aim of this study is to look at (a) how regularly the "icancope with pain" app is used and (b) any effect the app has on young people's health. this study will compare two groups of young people: one that is using the new app, and one that receives usual medical care.


Eligibility criteria:
inclusion criteria 1. aged 12-18 years 2. diagnosed with jia (36) as per their rheumatologist 3. able to speak and read english 4. have self-reported average arthritis-related pain in the past week of \>3 on 10cm visual analogue scale (vas) 5. willing to complete online study outcome measures exclusion criteria: 1. moderate to severe cognitive impairments as per their healthcare provider 2. major co-morbid psychiatric \[conversion disorder, depression, anxiety disorder\] illnesses that may impact their ability to understand and use the "icancope with pain" intervention as per their rheumatologist 3. received more than 4 cbt sessions for pain management in the past 6 months, as per their healthcare provider and self-report 4. patients from the department of haematology/oncology

Keywords: arthritis self-management pain
soy isoflavone tablets: effects on sleep, quality of life, symptoms and cognitive function in menopausal women

Conditions: Hot Flashes

Summary: the study was done to elucidate relationships between midlife women's self-reported hot flashes, neuropsychological symptoms, cognitive performance or sleep.


Eligibility criteria:
inclusion criteria: * at least 5 hot flash episodes and/or night sweats per 24 hours exclusion criteria: * body mass index (bmi) more than 34 kg/m2 * hypertension * shift work * psychiatric or medical conditions that would affect outcome measures * more than 4 caffeine drinks per day * more than 10 cigarettes per day * more than than 7 alcohol drinks per week
evaluation of muscle activation efficiency in challenging subjects

Conditions: Obesity; COPD

Summary: the purpose of this study is to determine whether muscle activation can be accomplished more effectively and comfortably in challenging subjects using novel configurations of an activation device. a novel device will be compared side by side with a market leading device.


Eligibility criteria:
inclusion criteria: * bmi \> 30 (wing 1 of study) * non-hospitalized with confirmed diagnosis of copd (wing 2 of study) exclusion criteria: * age \< 18 years * subject has an implanted pacemaker/defibrillator * subject diagnosed with epilepsy * subject has implanted metallic femoral rods * subject is chair- or bed-bound * subject has neuromuscular disease or abnormalities * subject bmi \> 45 * evidence of disease or condition that, in the opinion of the investigator, may compromise the conduct of or results of the study
multicenter study into individualized scanning for coronary artery disease

Conditions: Coronary Artery Disease

Summary: to evaluate intravascular attenuation of the coronary arteries and image quality in an individualized scan and cm injection protocol whereas both scan and injection parameters are tailored to the individual patient in a north american, european and asian patient population. to evaluate the radiation dose and contrast media dose of this individualized approach for ccta in an american, european and chinese patient population. to evaluate the injection parameters required for an average american, european and chinese patient population.


Eligibility criteria:
inclusion criteria: * to be eligible for the study: (all answers must be "yes" for subject to be eligible.) 1. referred for a clinically indicated ccta scan. 2. patient aged older than 18. 3. subject must provide written informed consent prior to any study-related procedures being performed. 4. subject must be willing to comply with all clinical study procedures. 5. atypical or typical complaints of angina. 6. no previous cardiovascular history. 7. possibility of 'flash' mode scan; patient heart rate below 70 beats per minute and regular rhythm. exclusion criteria: * the presence of the following excludes subjects from the study: (all answers must be "no" for subject to be eligible.) 1. contraindications for ct coronary angiography, including: 1. inability to perform a breath hold for at least the expected scan time 2. unstable angina 3. hemodynamic instability 4. known history of cad 5. pregnancy 6. renal insufficiency (defined as creatinine \<1.5 mg/dl or gfr\<30 ml/min) 7. iodine allergy 2. insufficient cannula venous access (preferred 18g, minimal 20g cannula) 3. subject has an acute psychiatric disorder. 4. subject is unwilling to comply with the requirements of the protocol. 5. subject has previously entered this study.
the effect of different adhesion strategies on the clinical success

Conditions: Poor Aesthetic of Existing Restoration of Tooth; Dental Restoration Failure of Marginal Integrity; Unacceptable Morphology of Tooth Restoration; Secondary Caries

Summary: the study will involve 41 people who regularly seek treatment at clinics. participants must be in generally good health and be older than eighteen. must have at least 20 teeth in an occlusion and maintain appropriate dental hygiene. they have to be treated for a minimum of four non-cancerous cervical lesions in their mouths.four non-carious cervical lesions from patients will be separated into four groups, and adhesive material will be applied to the lesions in each group using different procedures. evaluation will be performed based on world dental federation (fdi) criteria after initial, ½, 1, 2, 3, 4, and 5 years.

the study will involve 41 people who regularly seek treatment at clinics. participants must be in generally good health and be older than eighteen. must have at least 20 teeth in an occlusion and maintain appropriate dental hygiene. they have to be treated for a minimum of four non-cancerous cervical lesions in their mouths.four non-carious cervical lesions from patients will be separated into four groups, and adhesive material will be applied to the lesions in each group using different procedures. evaluation will be performed based on world dental federation (fdi) criteria after initial, ½, 1, 2, 3, 4, and 5 years. in each evaluation period, esthetic (surface gloss, surface coloration, marginal discoloration, color match and translucency, esthetic anatomic form), functional (fracture and retention, marginal adaptation), and biologic criteria (postoperative sensitivity and vitality, caries recurrence) will be evaluated.

Eligibility criteria:
inclusion criteria: * over the age of 18 years * good oral hygiene normal occlusal relationship with natural dentition * at least 20 teeth are in occlusion the tooth with the lesion must be vital. non-mobile and non-carious * accepts healthy volunteers exclusion criteria: under the age of 18 * poor oral hygiene poor general health condition * bruxism or uncontrolled parafunction * patients with periodontal or gingival diseases