Kornimate/medical-research-clean huggingface dataset:
prevalence of chronic oral graft versus host disease risk factors in pediatric patients

Conditions: Oral Disease; Graft-versus-host-disease; Stem Cell Transplant Complications; Pediatric Disorder

Summary: our aim is estimating the prevalence and predicting risk factors for developing chronic oral graft versus host disease in pediatric patients subjected to hematopoietic stem cells transplantation

the study will be held in children's cancer hospital egypt for pediatric patients who underwent bone marrow transplantation. this study describes oral conditions, detect possible oral pathological manifestations and evaluate their prevalence as well as correlating it to assumed risk factor as age, sex, type of the transplant , previous acute attack of graft versus host disease and other organ involvement . a standardized transplant database questionnaire will be completed clinical examination will be performed then findings will be recorded for oral mucosal lesions , salivary flow rate in milliliter , mouth opening in milliimeter. sample size estimation : the aim of this study is to screen pediatric patients at least three months after they undergo allogeneic hematopoietic stem cells transplantation to detect any risk factors for developing oral manifestations of chronic graft versus host disease during this period. every patient fulfilling inclusion criteria in the hospital will be recruited consecutively in a period of six months starting from april 2019.

Eligibility criteria:
inclusion criteria: 1. pediatric patients aged between 3 and 13 who underwent bone marrow transplantation at least 3 months ago. 2. neoplastic or non- neoplastic diseases. 3. patient receiving any protocol of gvhd prophylactic treatment. exclusion criteria: 1. patients who do not approve to join the study. 2. patient receiving chemo or radiotherapy .

Keywords: oral gvhd pediatric
prophylaxis of neuropathic pain by mémantine

Conditions: Neuropathic Pain

Summary: the aim of this study is to evaluate if memantine administered during 4 weeks beginning 2 weeks before surgery induces a decrease of painful intensity 3 months after surgery, compared to placebo group.

the aim of this study is to evaluate if memantine administered during 4 weeks beginning 2 weeks before surgery induces a decrease of painful intensity 3 months after surgery, compared to placebo group.

Eligibility criteria:
inclusion criteria: * 18 years old * patient suffering breast cancer with mastectomy/tumorectomy with or within cleaning 2 weeks after inclusion with or within pre-emptive chemotherapy exclusion criteria: * against-indication at memantine administration : hypersensitivity at active substance or excipients, hypertension, antecedent cerebrovascular accident, severe cardiac insufficiency * diabetic patient (type i and ii) * patient with medical or surgical antecedents * patient receiving treatment with amantadine, ketamine, dextrometorphan, l-dopa, dopaminergic, anticholinergic agonists, barbiturate, neuroleptic, imao, antispastic agents, dantrolen or baclofen, phenitoin, cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine, hydrochlorothiazide, warfarine * patient with alcohol addiction * woman in childbearing age not using effective contraceptive method, pregnant or lactating woman * patient who participated in another clinical trial, located in exclusion period or received benefits \> 4500 euros during 12 months before the beginning of trial

Keywords: pre-emptive administration post-operative administration prophylaxis memantine post-mastectomy/tumorectomy neuropathic pain
a study to assess the efficacy of rituximab (mabthera) in first line treatment of chronic lymphocytic leukemia (cll)

Conditions: Leukemia, Lymphocytic, Chronic, B-Cell

Summary: this single arm study will assess the efficacy and safety of rituximab in combination with fludarabine and cyclophosphamide, followed by rituximab maintenance therapy, as first line treatment of participants with cll.


Eligibility criteria:
inclusion criteria: * cll according to world health organization diagnostic criteria * active disease * no previous treatment * eastern cooperative oncology group (ecog) performance status of 0, 1, or 2 exclusion criteria: * transformation to aggressive b-cell malignancy (prolymphocytic leukemia, large-cell lymphoma, hodgkin's lymphoma) * other malignancies except for localized skin cancer * continuous systemic corticosteroid treatment * known infection with hepatitis b or c
extracorporeal shock wave therapy for dysmenorrhea

Conditions: Primary Dysmenorrhea

Summary: purpose of this study to investigate the effect of extracorporeal shock wave therapy on pain and prostaglandin level in patient with primary dysmenorrhea

this randomized controlled trial is to determine the effect of shock wave therapy in the treatment of primary dysmenorrhea. females are randomly assigned into 2 groups: group a swt treatment plus dietary modification during pd (n=25） group b:dietary modification only (n=25）; participants in group b will receive dietary modification for three successive months the numerical rating scale (nrs) and prostaglandin blood level will be recorded and evaluated before and after treatment.

Eligibility criteria:
inclusion criteria: 1. ages ranged between18 - 25 years old. 2. body mass index (bmi) will not exceed 30kg/m2. 3. females will be diagnosed by the physician as primary dysmenorrhea. exclusion criteria: 1. secondary dysmenorrhea . 2. mental health problem such as depression and anxiety. 3. irregular periods
robotic bariatric database (rbd) collaborative

Conditions: Weight Loss; Obesity

Summary: with increased prevalence of obesity in the general population over the past 30 years, researchers have been focused on the development of new treatment options to achieve long-lasting weight loss. in 1991, the national institutes of health conference statement on gastrointestinal surgery for severe obesity developed a consensus stating that bariatric surgery was the most effective treatment for obesity since it is associated with good long-term results in terms of weight loss, glycemic control and decreased mortality. to collect and store clinical data related to the treatment outcomes of robotic bariatric surgery in order to develop an evidence base such that physicians can provide the best possible care to patients undergoing surgical weight loss interventions.

with increased prevalence of obesity in the general population over the past 30 years, researchers have been focused on the development of new treatment options to achieve long-lasting weight loss.

Eligibility criteria:
inclusion criteria: * \> 18 years of age * eligible for or have undergone robotic bariatric surgery per the treating physician * undergone robotic bariatric surgery between january 2018 and december 2019 exclusion criteria: * do not meet the study inclusion criteria l
bifidobacterium infantis m-63 improves mental health in irritable bowel syndrome developed after a major flood disaster

Conditions: Irritable Bowel Syndrome; Abdominal Pain; Small Intestinal Bacterial Overgrowth

Summary: a 3-month study was conducted in flood victims from affected villages in the tumpat district, kelantan. participants were given either probiotic, bifidobacterium infantis m63 (m-63 group) or no probiotics (control group) for three months. at baseline and 3-month, participants were assessed for thewater, sanitation and hygiene (wash) practices, abdominal symptoms, breath testing for hydrogen and methane to detect the presence of sibo and also fecal samples for gut microbiota profiling.

there is an observed rise in cases of acute gastroenteritis and post-infectious irritable bowel syndrome (pi-ibs) during the peak flood period. one major reason is poor sanitation, water and hygiene practice by flood victims during the flood because of poor access to clean water. the mechanism how poor hygiene causes non-specific abdominal complaints is unknown. the investigators speculated that small intestinal overgrowth (sibo) is the fundamental basis for the increase in reported cases of acute gastroenteritis and abdominal complaints among flood victims. the investigators further speculated that administration of antibiotics or probiotics could reduce the abdominal symptoms after three months. therefore, the intervention study was conducted for three months. compliance of participants was checked by a diary given to participants in the m-63 group to document their daily intake of probiotics. this study will for the first time demonstrate the fundamental mechanism behind the poor wash practices and gastrointestinal disturbances after flood. also this study would support a role for probiotic intervention to reduce abdominal complications when the next flood occurs.

Eligibility criteria:
inclusion criteria: * adults aged ≥18 years; flood victims who fulfilled the rome iii criteria for ibs developed after flood, able to perform breath-testing, able to provide stool specimens, and able to complete three months of prospective intervention. exclusion criteria: * adults who took antibiotics or probiotics three months prior to and after flood had taken place; previous abdominal surgery and presence of significant medical and psychiatric co-morbidities.

Keywords: gut microbiota probiotics abdominal pain small intestinal bacterial overgrowth mental
prophylactic npwt to reduce ssi in colorectal surgery

Conditions: Surgical Wound Infection

Summary: the purpose of this study is to see if the negative pressure wound therapy (npwt) system is effective and safe for the prevention of superficial and deep incisional surgical site infections (ssi) in high risk patients within 30 days after elective colorectal surgery. it has been shown that patients with an ibd, patients undergoing a reoperation or patients with certain comorbidities are at a higher risk of developing an ssi. the npwt device is a wound dressing with a vacuum system that can be placed over abdominal wounds. the study will include up to 400 patients at this single site, where these high risk patients will be randomized to receive either one of two arms. the first arm involves the placement of the npwt device in the immediate postoperative period over abdominal wounds after clean/contaminated colorectal surgical procedures. the device would then be left on for 5 days. the second arm would be standard of care and would entail routine postoperative protocols. subjects will then be seen once at a 30 day (± 7 days) follow-up visit to assess for the development of ssis.


Eligibility criteria:
inclusion criteria: * ages 18-80 * patients who will undergo an open or laparoscopic-assisted clean/contaminated colorectal surgical procedure. * patients must either have an inflammatory bowel disease, undergoing reoperation within 30 days, or have two or more of the following risk factors: presence of an ostomy, type ii diabetes, bmi greater than 30, immunosuppression, malnutrition, current smoker, chronic kidney disease (creatinine \> 1.2), and disseminated cancer. exclusion criteria: * patients currently enrolled in another interventional clinical trial, * patients with a bmi less than 20, patients with a current abdominal abscess or infection (including a known urinary tract infection), * patients allergic to or hypersensitive to silver, patients planning to undergo a second colorectal surgical procedure (e.g., colostomy or ileostomy takedown) or any other general surgery in less than 30 days of index-surgery, * any patient in which the planned surgery would include: i) placement of a stoma in the principal incision; ii) placement of a drain into the supra-peritoneal fascia space that emerges through the principal incision; iv) placement of a drain into the intraperitoneal space that emerges through the principal incision; and v) supplementation of any of the irrigation fluid with antibiotic or antiseptic drugs, * patients with healing disorders, * pregnant women, * prisoners, or * any patient that is deemed unsuitable for the study by the principal investigator or the operating surgeon/co-investigator.

Keywords: negative pressure wound therapy colorectal surgery prevena surgical site infection
learn to quit-hiv pilot study

Conditions: HIV/AIDS; Smoking Cessation; Tobacco Use Disorder

Summary: the study team will conduct a feasibility, acceptability, and preliminary efficacy trial comparing learn to quit-hiv (n=30) to an app based on u.s. clinical practice guidelines only (nci quitguide; n=30) among hiv-positive smokers. both apps will be integrated with nrt and ongoing hiv clinical care.


Eligibility criteria:
inclusion criteria: * hiv-positive * currently engaged with an hiv care provider * self-report smoking 5 cigarettes or more per day during the past 30 days * age 18 years or older * current interest in quitting smoking * currently own a functioning android or apple smartphone exclusion criteria: * no desire to quit smoking * inability to attend study sessions * inability to provide informed consent * any medical condition or concomitant medication that could compromise subject safety or treatment, as determined by the principal investigators and/or study physician * presence of contraindications for nicotine patch * previous allergic reaction or hypersensitivity to nicotine patch (lifetime) * current use of nicotine replacement therapy or other smoking cessation treatment (e.g., bupropion, varenicline) * pregnant, planning to become pregnant, nursing, or becoming pregnant during the study * current untreated and unstable diagnosis of alcohol/substance abuse or dependence (eligible if past abuse/dependence and if receiving treatment and stable for \>30 days)
flutamide in the prevention of prostate cancer in patients with neoplasia of the prostate

Conditions: Prostate Cancer

Summary: rationale: chemoprevention therapy is the use of certain drugs such as flutamide to try to prevent the development of cancer. flutamide may be effective in the prevention of prostate cancer. purpose: randomized clinical trial to study the effectiveness of flutamide in preventing prostate cancer in patients who have neoplasia of the prostate.

objectives: i. determine the ability of flutamide to reduce the incidence of prostate cancer in patients with high grade prostatic intraepithelial neoplasia. ii. determine the effect of this regimen on a series of endpoint biomarkers in these patients. iii. assess the quality of life of these patients. outline: this is a randomized, double blind, placebo controlled, multicenter study. patients are stratified according to age (under 65 versus 65 and over), psa (0-2.5 versus 2.6-4.0 versus 4.1-10 versus greater than 10 ng/ml), pin (on one biopsy versus on two biopsies), and family history (prostate cancer in brother, father, or uncle versus no prostate cancer in these relatives). patients are randomized to one of two treatment arms.

Eligibility criteria:
disease characteristics: histologically confirmed high grade prostatic intraepithelial neoplasia confirmed by second prostate biopsy within 180 days of first biopsy no prior or concurrent prostatic carcinoma no prior hormonal replacement or antiandrogen therapy patient characteristics: age: 18 and over performance status: ecog 0-1 life expectancy: greater than 5 years hematopoietic: not specified hepatic: sgot and alkaline phosphatase no greater than 2 times upper limit of normal no hepatitis b or c or liver cirrhosis renal: not specified other: fertile patients must use effective contraception no other prior malignancy in past 5 years except carcinoma in situ or nonmelanoma skin cancer prior concurrent therapy: biologic therapy: not specified chemotherapy: not specified endocrine therapy: see disease characteristics radiotherapy: no prior radiotherapy surgery: not specified

Keywords: prostate cancer
tick-borne illness and clothing study

Conditions: Tick Bites; Tick-borne Illness

Summary: the high risk of acquiring tick-borne diseases by outdoor workers is well documented. workers most at risk include, foresters, park rangers, land surveyors and other outdoor workers have frequent exposure to tick-infested habitats. many north carolina state employees with outdoor occupations report multiple tick bites each year, which indicates that existing tick preventive strategies may be ineffective. the principal goal of this study is to assess whether the use of long-lasting permethrin impregnated uniforms can reduce the number of tick bites sustained by north carolina outdoor workers.


Eligibility criteria:
inclusion criteria: * being over 18 years of age * employee of nc division of forest resources, the nc division of parks and recreation, nc wildlife resources commission, or nc county and local parks and recreation who work in central and eastern north carolina * an average of 10 or more hours of outdoor work per week during tick season * self-reported prior work-related tick bites exclusion criteria: * pregnancy * non-english speaking * known allergy to insecticides
prevalence of trismus in patients with maxillary cancer with and without radiation therapy in the egyptian population.

Conditions: Maxillary Neoplasms

Summary: this study aims at evaluating the prevalence of trismus among maxillary cancer patients in the egyptian population and the effect of radiotherapy on the occurrence of trismus.

the enrolled participants who meet the eligibility criteria and signed the informed consent of participation in the study will undergo clinical examination to determine the maximum mouth opening after performing surgery only and /or after radiotherapy in case of adjuvant therapy the maximum mouth opening will be measured in (mm) by using a digital caliper device and will be recorded in the patient sheet, reading of less than 35mm will be considered trismus while above 35mm or more will be considered normal (no trismus)

Eligibility criteria:
inclusion criteria: * patients with maxillary cancer exclusion criteria: * patients under 18 yrs . * patients with tmj disorders before surgery * patients on chemotherapy * - tumors in other sites( tongue , buccal mucosa , salivary glands, mandible)

Keywords: surgery , trismus, oral
effect of acupuncture and laser acupuncture in the treatment of people with chronic nonspecific low back pain.

Conditions: Low Back Pain

Summary: the aim of this randomized clinical trial will be to compare the efficacy between acupuncture and laser acupuncture on pain and disability in people with chronic nonspecific low back pain .

forty-four patients with chronic cnlbp of more than three months duration will be randomly allocated to two groups: acupuncture group (acp) (n = 22) and laser acupuncture group (lacp) (n = 22).interventions will last one hour, and will happen twice a week for 5 weeks. the primary clinical outcomes will be pain intensity (11-point numeric pain rating scale) as measured and functional disability (oswestry disability index).the secondary outcomes will be the pain catastrophizing scale, patient-specific functional scale and fingertip-to-floor test. evaluations will be performed before and after the first session, after 5 weeks of treatment, and three months after randomization (follow-up). the findings will be analyzed statistically considering a 5% significance level (p ≤ 0.05).

Eligibility criteria:
inclusion criteria: * age 18-65 years; * non-specific lbp for at least three months * pain intensity of at least 2 points measured using the numeric pain rating scale exclusion criteria: * pregnancy; * any contraindication to acp or having undergone treatment in the previous six months * having undergone spinal surgery in the previous six months; * serious spinal pathology (e.g. metastasis, spinal fracture, inflammatory, and infective diseases, caudal equine syndrome, canal stenosis, osteoporosis, rheumatoid arthritis and lumbar radiculopathy); * currently in an acute inflammatory phase of known gastrointestinal or urinary diseases (such as cholecysticis, renal calculi, peritonitis, appendicitis);

Keywords: acupuncture laser therapy low back pain acupuncture points
evidence-based assessment of medication sensitivity in acute hepatic porphyria

Conditions: Porphyrias

Summary: this is an observational study collecting patient/caregiver reports on suspected medication/drug-induced acute porphyria attacks, as well as safe use of drugs previously labeled "unsafe" or with unknown risk. participants will be recruited through the rdcrn contact registry for the porphyrias consortium. the study will be advertised on the consortium website and through the american porphyria foundation's social media network.

contact registrants will be sent an email invitation describing the study. a unique link will be generated for each registrant and included in the email invitation. after 2 weeks, a second email invitation will be sent to the registrants who have not yet participated. after 1 month, a third email invitation will be sent to the registrants who have not yet participated. we may send additional emails periodically (e.g. every 6-12 months) to subjects enrolled to remind them to complete new surveys if they have taken any other medications of interest or have experienced any new reactions/attacks. if the registrant wants to participate in the study, he/she will follow the survey link in the email invitation, which directs him/her to an irb-approved online consent form. if the participant consents to participate, he/she will be directed to online forms to report general information (ex. age, sex, test results, family history), suspected medication-related acute attacks, and "uneventful use of possibly risky medication". if a patient has multiple medication-related acute attacks, the patient/caregiver will be able to submit multiple report forms that will be linked. in addition to the report forms, patients will be asked to review a list of "medications of interest" and report current or past use.

Eligibility criteria:
inclusion criteria: * able to read and write in english * enrolled in the rdcrn pc contact registry * self-reported patient or caregiver of patient with acute porphyria there are no restrictions on age, sex or ethnicity. however, the following criteria will be applied to those reports that are considered evaluable (analyzed and scored): 1. medication name must be specified 2. the data elements required in the scoring system must be complete exclusion criteria: * unable to provide informed consent and complete forms

Keywords: porphyrias variegate porphyria hereditary coproporphyria acute intermittent porphyria