Kornimate/medical-research-clean huggingface dataset:
study of the preservation of the left colic artery on rectum cancer surgery

Conditions: Rectum Cancer

Summary: to evaluate the influence to the blood supply of the anastomosis and the harvest of the no. 253 lymph nodes in different surgical methods--- preserving the left colic artery (lca) and resect the no. 253 lymph node specifically in the radical resection of rectal carcinoma or dividing at the root of the inferior mesenteric artery (ima) in the radical resection of rectal carcinoma.

methods: the patients who got rectal carcinoma are divided into two groups. both groups will receive the radical resection of rectal carcinoma. we preserve the left colic artery and resect the no. 253 lymph node specifically in group a and divide at the root of the inferior mesenteric artery in group b, we insert a trocar into the arterial arcade at the proximal site of the anastomosis and measure the blood pressure of the arterial arcade in the operation, which can reflect the blood supply of the anastomosis. besides, we will measure the length of the colon from the anastomosis to the level of the root of the ima. expecting results：the blood pressure of the arterial arcade in group a will be higher than that in group b. and the patients in group a will have less chance to get anastomotic fistula. expecting conclusions: preserving the lca and resecting the no. 253 lymph node specifically in the radical resection of rectal carcinoma can improve the blood supply of the anastomosis and decrease the incidence of anastomotic fistula, and won't affect the harvest of the no. 253 lymph node.

Eligibility criteria:
inclusion criteria: * patients coming to firstjilinu diagnosed rectum cancer by endoscopy and pathology. * the rectum cancer is the first malignant neoplasm the patient has got. * the cancer is solitary, and is 3cm to 20cm to the anus. * the surgical method is limited to dixon. exclusion criteria: * being in the acute phase of inflammation before operation and emergency surgery. * patients receiving steroid medication or preoperative radiotherapy。 * discovering macrometastasis before or in the operation. * the rectum cancer that can't be radical resected.
usg guided esp block in spinal surgery

Conditions: Postoperative Pain

Summary: american society of anaesthesiologist physical status i-ii, aged between 18-65, 40 patients which underwent lumbar spinal surgery will recruited to this study. these subjects will ultrasound (usg) guided erector spinae block will perform at t10 level (bilaterally) to the all patient under general anaesthesia. 15 ml bupivacaine %0.5 and 5 ml lidocaine %2 will use for usg guided esp block. 0.1 microgram/kg morphine will apply intravenously and diclofenac na 75 mg intramuscularly will apply at last 30 minutes of surgery postoperative analgesia to all patients. postoperative pain assessment will perform with visual analog scale (vas)

american society of anaesthesiologist physical status i-ii, aged between 18-65, 40 patients which underwent lumbar spinal surgery will recruited to this study. the patients were randomly allocated into two groups (1:1), via a computer-generated randomization list. ultrasound (usg) guided erector spinae block will perform at t10 level (bilaterally) to the 20 patients under general anaesthesia in group e and same volume saline will apply to the esp block region at t10 level for control group (group c). total intravenous anaesthesia (propofol+remifentanil) will perform to the all patients. 15 ml bupivacaine %0.5 and 5 ml lidocaine %2 will use for usg guided esp block. 0.1 microgram/kg morphine intravenously and diclofenac na 75 mg intramuscularly will apply for postoperative analgesia to the all patients at last 30 minutes of surgery. postoperative pain assessment will perform with visual analog scale (vas). vas, morphine consumption and complications will record. the rescue analgesic 0.4 mg/kg mepheridine will administer intravenously whenever the patient requested to the analgesic. diclofenac sodium 75 mg will repeat to the all patients at the 12th of postoperative period, intramuscularly.

Eligibility criteria:
inclusion criteria: * accepting to participate the study * asa i-ii patients * the patients underwent spinal surgery exclusion criteria: * non volunteers * asa iii and over * renal and hepatic failure * emergency surgical procedures

Keywords: erector spinae plane block postoperative analgesia spinal surgery
incentives and glucose adherence in diabetes

Conditions: Diabetes in Pregnancy

Summary: diabetes in pregnancy carries significant pregnancy specific risks and requires frequent glucose monitoring to reduce these risks. this project compares the effect of two incentive schemes on adherence rates of glucose testing in pregnancy.

diabetes in pregnancy is associated with increased risks of maternal and fetal complications and can be challenging to manage due to increasing insulin requirements with advancing gestational age. based on standard of care guidelines, patients with diabetes check their blood glucose at least 4 times per day. optimal management requires frequent glucose self-monitoring and active management of abnormal blood sugars and medications by clinicians. poorly controlled diabetes has both significant maternal and neonatal consequences: improving test adherence could benefit both the pregnant woman and her fetus. in this study, we propose to test the effect of two incentive schemes on rates of glucose monitoring on pregnant women with diabetes requiring medication. pregnant women with diabetes requiring medication are invited to participate if they meet specific inclusion criteria (\<28 weeks) and followed in our outpatient clinic. participants are randomized into one of three groups: 1. control group - receive compensation at time of enrollment, 2. positive incentive group - receive compensation per test completed 3. loss aversion group - receive between a range of compensation depending on their overall level of adherence. primary outcome of the study is frequency of prescribed glucose testing in pregnancy

Eligibility criteria:
inclusion criteria: * pregnant women with insulin dependent diabetes prior to 28 weeks gestation. exclusion criteria: * incarcerated, not english speaking
distal hypospadias repair outcome

Conditions: Distal Penile Hypospadias (Disorder)

Summary: aim is : to define the preoperative parameters that may influence the results of distal hypospadias repair

hypospadias is a congenital deformity where the opening of the urethra (the meatus) is sited on the underside (ventral) part of the penis, anywhere from the glans to the perineum. it occurs in 1 in 250 live male births. it is often associated with "hooded" foreskin and chordee (ventral curvature of the penis shaft). hypospadias can be classified according to the anatomical location of meatus: distal-anterior hypospadias (located on the glans or distal shaft of the penis and the most common type of hypospadias) intermediate-middle (penile). proximal-posterior (penoscrotal, scrotal, perineal). diagnosis includes a description of the local findings: position, shape and width of the orifice presence of atretic urethra and division of corpus spongiosum appearance of the preputial hood and scrotum size of the penis curvature of the penis on erection. aim of hypospadias surgery :(2) is to correct penile curvature,to form neo-urethera of an adequate size, to bring the neomeatus to the tip of glans, and offer satisfactory cosmetic results. the ideal age at surgery for primary hypospadias repair is usually 6-18 months. the complication rate is about 10% in distal hypospadias repair. complications include: 1. uretherocutaneous fistula. 2. meatal stenosis. 3. urethral stricture. 4. urethral diverticulum. after hypospadias repairs, long-term follow-up is necessary, up to adolescence, to detect urethral stricture, voiding dysfunction and recurrent penile curvature.

Eligibility criteria:
inclusion criteria: * child with distal hypospadias, uncircumcised , without meatal stenosis and no previous surgery for hypospadias exclusion criteria: * any surgical manipulation includes circumcision or meatotomy. patient refusal to be enrolled in the research. patient lost follow up in the first six months

Keywords: penile hypospadias
evaluation of the endovascular repair for aortic aneurysm (evar) program at lhsc

Conditions: Abdominal Aortic Aneurysm

Summary: the purpose of this study is to compare the cost effectiveness, quality of life and outcomes of the endovascular stent graft repair with the open surgical repair of abdominal aortic aneurysms.

abdominal aortic aneurysms have been traditionally repaired using the standard open surgical technique. the use of endovascular stent grafts(evar) to treat aortic aneurysms has been ongoing for approximately 8-10 years. use of evar to treat aortic aneurysms in high risk has been reported to be beneficial. however, the costs of this therapy are quite significant and therefore in order to best understand the cost effectiveness of this type of aneurysm treatment, an extensive prospective comparative evaluation is required. this study will compare outcomes and cost-effectiveness for patients receiving evar, with high surgical risk, and osr, with low surgical risk, and osr, where there is high surgical risk and not suitable for evar based on anatomical complexity. demographic, medical, health care resource utilization, cost, and quality of life information is collected from participating patients over a period of a year following repair.

Eligibility criteria:
inclusion criteria: * infrarenal abdominal aortic aneurysm, * \> 5.5 cm diameter * scheduled for elective surgical repair exclusion criteria: * previous repair of aaa
unmasking the dynamic component in functional mitral regurgitation in chronic heart failure

Conditions: Heart Failure

Summary: background: chronic heart failure (hf) is frequently accompanied by functional mitral regurgitation (fmr) caused by left ventricular (lv) remodeling and subsequent papillary muscle displacement resulting in mitral valve (mv) leaflet tethering, dilatation and flattening of the mitral annulus and reduced closing forces. up to moderate fmr affects the majority of patients with systolic heart failure - roughly 80% - still independently increasing mortality. every fifth patient with chronic heart failure experiences a progression of fmr during the first three years of follow up despite guideline directed heart failure therapy, which is independently associated with a poor prognosis. furthermore, mr is well known to have a strong dynamic component not only during the cardiac cycle at rest and with exercise. aims of the study: the investigators therefore aim to assess whether stress tests in patients with functional mitral regurgitation unmasks significant dynamic mitral regurgitation or might aid to identify patients at risk of fmr progression in patients with functional mitral regurgitation in heart failure with reduced ejection fraction (hfref) under guideline directed medical therapy. study design: the investigators will prospectively perform stress tests in all patients with non-severe fmr that are routinely seen in the heart failure outpatient clinic. study patients: patients with stable chronic heart failure on optimal medical therapy, who undergo routine ambulatory clinical control visits in the heart failure outpatient ward of the medical university of vienna, will be included in the present study. a written informed consent will be obtained before inclusion. inclusion criteria will be a non-severe fmr, an age of at least 18 years and stable heart failure related medical therapy in the last 3 months. methods: all patients that are willing to participate will undergo stress testing (i.e. volume challenge and low dose dobutamine stress) to determine whether patients display severe dynamic fmr under stress conditions. within the registry patients will be followed-up during routine ambulatory visits for three years. patients with severe dynamic functional mitral regurgitation will be compared to patients without severe dynamic fmr. record of clinical events during the fup will be performed. routine laboratory parameters, have been measured at inclusion. additionally, neurohormone patterns will be measured at baseline and at peak stress. sample size: expecting a prevalence of severe dynamic fmr of 20%, the investigators would include a total of 150 chronic heart failure patients taking also into account a study-dropouts of 20% ( loss of follow-up and mortality).


Eligibility criteria:
inclusion criteria: * non-severe fmr, * age of at least 18 years, * stable heart failure related medical therapy in the last 3 months. exclusion criteria * non-willing to participate * myocardial infarction, * cardiac decompensation within the last 3 months, * pregnancy, * life expectancy of less than 1 year for non cardiac reasons.
aerobic exercise in children with moderate and severe asthma

Conditions: Asthma

Summary: regular aerobic physical activity in short-term moderate asthma and severe: * reduce the levels of inflammatory mediators * improves functional capacity * improves quality of life * improved lung function * reduces the sensation of dyspnea * improves symptoms scores and medication use

methods: is designed a randomized clinical trial, efficacy, outpatient physical therapy developed in the institute of integrative medicine teacher fernando figueira (imip). a pilot study with 20 participants will be made initially to obtain a sample calculation. subjectively estimated it will take about 50 participants, with possible losses. will include children older than eight years, diagnosis of moderate and severe persistent asthma according to criteria of global initiative national asthma (gina) and forced expiratory volume in one minute (fev1) below 80% predicted. will be excluded from the study associated with disease that limits physical activity, such as neuromuscular diseases, congenital or acquired heart disease, chronic lung disease associated exacerbation of the crisis and significant cognitive deficit, which makes the participant to respond adequately to the questionnaire and / or inability to meet the commands. eligible patients will be randomized into two groups: control group, which is not subjected to any kind of exercise and the intervention group, which will be submitted to aerobic exercise for 30 minutes three times a week for six weeks. the two groups will be evaluated before and at the end of six weeks by testing for 6-minute walk, analysis of dyspnea, questionnaire of quality of life, pulmonary function test (fev1, fvc), inflammatory markers (cytokine ).

Eligibility criteria:
inclusion criteria: * age greater than eight and less than nineteen years * diagnosis of moderate to severe persistent asthma according to criteria of gina * forced expiratory volume in one minute (fev1) below 80% of predicts * initiation of treatment with inhaled corticosteroids for at least eight weeks before the start of collection. exclusion criteria: * associated disease that limits physical activity, such as neuromuscular disease, congenital or acquired, severe cor pulmonate, severe congenital malformation * associated with chronic lung disease (cystic fibrosis, bronchiectasis, bronchopulmonary dysplasia, interstitial lung diseases * significant cognitive deficit, which makes the participant to respond adequately to the questionnaire and / or failure to meet the commands * exacerbation of crisis (this will be a temporary exclusion criterion, as having taken action as directed by medical routine, the participant can return to training) * mental deficit.

Keywords: asthma, aerobic exercise, child, cytokines
relationship of facial pattern with bruxism

Conditions: Bruxism

Summary: the purpose of this study is to determine if the facial pattern is related to the degree of bruxism because the muscles of mastication are the factors of force to the wear of the teeth.


Eligibility criteria:
inclusion criteria: 1. both genders 2. age 18 to 60 years 3. case studies to understand orthodontic intraoral photographs of the upper and lower dental arches, and models of lateral skull radiography for orthodontic 4. cases with any facial biotype development. exclusion criteria: 1. totally toothless people 2. partially toothless the posterior (include both molars and premolars). 3. dawn syndrome,alzheimer , partial or bilateral facial palsy, autism, which manifest with bruxism 4. some other syndrome which alters the pattern of facial development as pierre robin,crouzon

Keywords: facial patterns bruxism masticatory muscles
3-week study of asenapine, olanzapine and placebo for treatment of bipolar mania (p07008)

Conditions: Bipolar Disorder

Summary: bipolar disorder is characterized by mood swings that range from high (manic) to low (depressed) states. sometimes, symptoms of both depression and mania are present (mixed episodes). asenapine is an investigational medication for the treatment of manic or mixed episodes of bipolar disorder. this is a 3-week study that will test the safety and efficacy of this medication. patients will receive either asenapine, olanzapine (a medication that is already approved for the treatment of bipolar mania), or placebo (no active medication). patients will be required to stay in the hospital for at least the first seven days of treatment. patients that complete the 3 week study may be eligible to continue in extension studies for an additional 9 (study a7501006) to 49 (study a7501007) weeks.


Eligibility criteria:
inclusion criteria: * have a dsmiv diagnosis of bipolar i disorder, current episode manic or mixed. exclusion criteria: * patients with unstable medical conditions or clinically significant laboratory abnormalities or patients who are rapid cyclers (ie. have had 4 or more (including current) mood episodes in the past 12 months); have any other psychiatric disorder other than bipolar i disorder as a primary diagnosis.
effect of targeted education for atrial fibrillation patients (application substudy)

Conditions: Atrial Fibrillation and Flutter

Summary: the aim of this study is to evaluate a new and innovative educational application based on targeted education on the adherence level for noacs (non-vitamin k antagonist oral anticoagulants) in af patients, compared with standard care, online targeted education and in-person targeted education. several other parameters (knowledge level, quality of life, symptom burden, self-care capabilities, evaluation of educational efforts) will be studied. if resources allow, cardiovascular outcomes, cost-effectiveness and cost-utility will also be investigated.

this substudy is part of the af-educare study (nct03707873): an extra study arm will be added to the main trial in which eligible af patients (= in possession of a smartphone and capable working with their smartphone) will test this new educational application. not eligible patients randomized to this group, will receive standard care. this extra study arm will additionally include an anticipated 221 patients (eligible plus not eligible patients). \[an anticipated total of 1259 af patients will be included for the af-educare study (1038 af patients) plus the af-eduapp substudy (221 af patients).\]

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years. 2. patients in whom af or atrial flutter is diagnosed with an electrocardiogram (12-lead, holter,...). 3. patients who are capable to sign the informed consent. exclusion criteria: 1. not able to speak and read dutch. 2. cognitive impaired (e.g. severe dementia). 3. life expectancy is estimated to be less than 1 year. 4. ongoing participation in another clinical trial. 5. pregnant women

Keywords: education application adherence
palbociclib in metastatic breast cancer: gene polymorphism-based study in egyptian patients.

Conditions: Hormone-receptor-positive Breast Cancer; Human Epidermal Growth Factor 2 Negative Carcinoma of Breast; Metastatic Breast Cancer

Summary: cyclin-dependent kinase (cdk) 4/6 inhibitors are a class of agents recently introduced in the clinic for the treatment of advanced hormone receptor-positive (hr+) and her2-negative (her2-) bc. palbociclib, ribociclib and abemaciclib have all been approved by the us food and drug administration (fda) and the european medicines agency among other regulatory bodies

several factors are thought to influence the variability of treatment efficacy and toxicity, including organ function, comedications, hormonal status, body weight, age, comorbidities, etc. among them, single nucleotide polymorphisms (snps) as rs1128503, rs2032583 are attracting huge interest to address the interindividual variability in drug response, whether in terms of efficacy or safety

Eligibility criteria:
inclusion criteria: * 1. adult patients (≥18 years). 2. confirmed diagnosis with mbc. 3. hr-positive/her2-negative mbc as ascertained by immunohistochemistry (ihc) or fluorescence in situ hybridization in primary or metastatic tissue samples. 4. patients with primary or secondary resistance to endocrine therapy. 5. patients with eastern cooperative oncology group (ecog) 0 or 1. 6. scheduled to receive palbociclib in first- or second-line metastatic setting. exclusion criteria: 1. prior exposure to fulvestrant or everolimus. 2. patients with uncontrolled brain metastases or symptomatic visceral spread who are at risk of life-threatening complications. 3. patients refusing to sign the written informed consent.

Keywords: metastatic breast cancer, palbociclib, pharmacogenomic