Kornimate/medical-research-clean huggingface dataset:
study of red blood cell transfusion triggers in patients undergoing hematopoietic stem cell transplantation

Conditions: Hematologic Malignancies

Summary: transfusion of red blood cells (rbcs) is important for the care of patients undergoing stem cell transplantation. stem cell transplants are used to treat blood cancers and bone marrow disorders. this involves the use of high doses of chemotherapy and/or radiation to kill cancer cells; but this damages the marrow and blood system. blood stem cells are transplanted by infusing into the recipient and blood counts recover over 2-3 weeks. before bone marrow recovery, rbcs are needed to support the patient. higher hemoglobin in these high risk patients may have benefits such as better energy and organ function. however, research in other areas of medicine suggests that a higher red cell count may be dangerous. taken together, it is unclear whether having a lower or higher red cell count is better for patients having a blood stem cell transplant. the investigators plan to study this by randomly assigning patients having a transplant to be transfused with rbcs either at a higher or lower hemoglobin level. in this way, the investigators will be able to accurately find out if there are any benefits or harms in having a lower or higher red cell count during the recovery period after blood stem cell transplantation.

1. males or females aged 18 years or older who are undergoing either an autologous or allogeneic hsct. 2. the indications for hsct may include, but not limited to the following diseases : 1. acute leukemia, myeloid, lymphoid or biphenotypic in 1st, 2nd remission or in relapse 2. chronic myeloid leukemia in chronic, accelerated or blast phase 3. chronic lymphocytic leukemia 4. myelodysplastic syndrome 5. myeloproliferative disorder 6. lymphoma 7. myeloma 3. all study patients must provide consent at least 1 day prior to scheduled hsct and provide written informed consent.

Eligibility criteria:
inclusion criteria: * patients are aged 16-70 undergoing either an autologous or allogeneic hsct for any hematologic malignancy exclusion criteria: * pregnant or lactating at the time of enrollment * already received red cell transfusion after hsct but prior to enrollment * unable/unwilling to provide informed consent. * patients receiving hsct for non-malignancy

Keywords: red cells transfusion trigger threshold hematopoietic stem cell transplantation
effect of thera band exercises on adhesive capsulitis post mastectomy

Conditions: Adhesive Capsulitis of Shoulder

Summary: breast cancer surgeries particularly mastectomy results in limited shoulder movement which can lead to arm, shoulder pain and stiffness. females who underwent mastectomy have reported a significantly higher incidence of shoulder morbidity

exercise therapy might help in reduction of pain and restoration of the range, coordination and control of movement in patients with adhesive capsulitis. graded resistance exercises are effective in decreasing fatigue levels, enhancing functional capacity and muscle strength. rehabilitation exercises which strengthen the scapular stability can be extremely beneficial in rehabilitation treatment of patients with shoulder pain and problems

Eligibility criteria:
inclusion criteria: * age ranged from 40-60 years. * 2nd stage of adhesive capsulitis, * shoulder pain and stiffness for at least 3 months. * restriction in shoulder flexion, abduction, internal and external rotation rom less than 50% when compared to the other shoulder. exclusion criteria: * shoulder or acromioclavicular joint osteoarthritis. * bone diseases. * infection. * severe osteoporosis. * tumors or metastasis. * history of previous shoulder trauma or accidental injuries. * previous history of dislocation. * previous history of surgery on the specific shoulder. * any other shoulder problems.
vestibular disorder and visuo-spatial functions

Conditions: Vestibular Diseases; Vertigo

Summary: the purpose of these studies is to determine whether vestibular disorders could affect visuo-spatial cognition. visuo-spatial cognition will be evaluated using a new questionnaire and a new computerized test using a digital tablet in different studies.


Eligibility criteria:
for participants of the questionnaire study : participants with vertigo complaints versus participants without vertigo complaints. for patients of the behavioural study : inclusion criteria: * vestibular disorder (with or without vertigo) * deafness / hard of hearing exclusion criteria: * neurological or psychiatric conditions * cochlear implant (for functional magnetic resonance imaging study)
pseudophakic accommodation

Conditions: Cataract

Summary: purpose: the aim of this study was to compare the effect of ciliary body training as proposed by manufacturers of accommodating iols and patient motivation on the pseudoaccommodative ability with a standard intraocular lens (sa60at). setting: department of ophthalmology, medical university of vienna. methods: this randomized, controlled, examiner-masked study comprised 80 eyes of 40 patients that underwent standard cataract surgery. patients were randomly assigned to a "motivated" or "non-motivated" (control) group. in the motivated group, subjects were told to take part in a special protocol to improve their near-reading ability after cataract surgery and were instructed not to use near adds for at least 3 months. follow-up examinations included best-corrected distance visual acuity (va), distance-corrected near va, best-corrected near va, defocus curve and reading speed, as well as pilocarpine-, cyclopentolate- and nearpoint-induced iol shift assessed with partial coherence interferometry.


Eligibility criteria:
inclusion criteria: * patients suffering from age-related cataract who are enrolled for cataract surgery. * age 50 to 75 years * \< 1 d of corneal astigmatism, estimated postoperative va of 20/30 or better and iol power between 16 and 27 dpt exclusion criteria: * patients with complications during cataract surgery or during the postoperative period, significant other ophthalmic diseases such as glaucoma, diabetic retinopathy, etc., or ophthalmic surgery other than cataract surgery

Keywords: pseudophakic accommodation
diet therapy in hemodialysis patients

Conditions: Hemolysis; Diet; Symptoms and Signs; Healthy

Summary: this study determined the effect of dietary education given to hemodialysis patients on dietary treatment and symptoms.

diet therapy is a part of the treatment of hemodialysis patients. in order for the treatment to be effective, it is necessary to comply with the diet. non-compliance with diet treatment affects the symptoms experienced by the patient, resulting in morbidity, low quality of life and mortality. knowing patients' compliance with diet therapy is important in ensuring symptom control. the aim of this study is to determine the effect of diet therapy on symptom management in hemodialysis patients.

Eligibility criteria:
inclusion criteria: being ≥18 years old, * agreeing to participate in the research, * being literate, * being able to communicate verbally, * receiving outpatient hd treatment three sessions a week at the same institution, * no impairment in mental and cognitive functions, * has been receiving hd treatment for at least three months (to be defined as a chronic hd program) exclusion criteria: * refusal to participate in the research, * being on peritoneal dialysis, * being diagnosed with a psychiatric disorder diagnosed by a psychiatrist, * the general condition (hemodynamically) is unstable (heart rate \< 100 mm/hg or diastolic bp\< 60 mm/hg),

Keywords: hemolysis diet healthy symptoms and signs
intensive versus standard follow up to improve continuous positive airway pressure (cpap) compliance

Conditions: Sleep Apnea

Summary: the purpose of this study was to compare the effects on sleepiness, quality of life, depression, hospitalization and deaths rate, of intensive vs standard interventions, on cpap adherence, 2 years after cpap initiation.

there is limited data concerning long-term randomized clinical trials proving the long-term efficacy of intensive use, follow programs on improving cpap use. therefore the investigators aimed to compare the effects on sleepiness, quality of life, depression, hospitalization and deaths rate, of intensive vs standard interventions, on cpap adherence, 2 years after cpap initiation.

Eligibility criteria:
inclusion criteria: * newly diagnosed obstructive sleep apnea syndrome by polysomnography according to standard criteria, * with moderate to severe sleep apnea, * no history of previously cpap therapy and * with an above-elementary school education. exclusion criteria: * refusal to participate, * refusal to cpap therapy, * previous cpap treatment, * central sleep apnoea syndrome, * cheyne-stokes breathing pattern, * obesity hypoventilation syndrome, * restrictive ventilator syndromes, * congestive heart failure, * history of life-threatening arrhythmias, * cardiomyopathy, * long term oxygen therapy, * family or personal history of mental illness, * with drug or alcohol abuse, * severe cognitive impairment, * concurrent oncologic diseases and * history of narcolepsy.
exacerbation risk in asthma

Conditions: Asthma

Summary: the purpose of this study is to conduct a comparative analysis of patients using tiotropium in combination with inhaled corticosteroids (ics) versus those that use long-acting β2-agonists (laba) medication in combination with ics.


Eligibility criteria:
inclusion criteria: * patients with least two asthma diagnosis * patients will be required to be concurrently on inhaled corticosteroids (ics)+tiotropium (tio) (specifically tiotropium respimat® 1.25 mcg) or ics/laba * patients will be required to have enrollment for at least 6 months prior to ics+tio or ics/laba use exclusion criteria: * patients with least two diagnosis of chronic obstructive pulmonary disease (copd) at any time during the study period * patients less than 12 years of age * patients on biologics within 6 months prior to ics+tio or ics/laba use * patients with prior tio or ics/laba use during the 6-month baseline period * patients with urinary bladder obstruction, urinary retention, and glaucoma * after the propensity score matching (psm) process, unmatched patients
comparative effectiveness multicenter trial for adhesion characteristics of ventral hernia repair mesh

Conditions: Ventral Hernia; Adhesions

Summary: the proposed study will compare the benefits, harms, and comparative effectiveness of intraperitoneal barrier-coated and non-barrier coated ventral hernia repair (vhr) mesh in reducing adhesions, adhesion-related complications, and adhesiolysis sequelae in actual patient subpopulations and clinical circumstances. a subset of the data will be analyzed to compare the benefits, harms, and comparative effectiveness of the laparoscopic and open approaches to adhesiolysis. a comprehensive array of health-related risk factors and patient-centered outcomes will be assessed in the investigators diverse patient population for proper multivariate data analysis. specific aim i: to evaluate and compare the adhesion characteristics of intraperitoneal barrier-coated versus non-barrier-coated mesh during abdominal re-exploration after prior ventral hernia repair. specific aim ii: to evaluate and compare the adhesion-related complications and adhesiolysis-related complications of intraperitoneal barrier-coated versus non-barrier-coated mesh during abdominal re-exploration after prior ventral hernia repair. specific aim iii: to determine the comparative effectiveness of intraperitoneal barrier-coated versus non-barrier-coated ventral hernia repair mesh in reducing adhesions, adhesion-related complications, and adhesiolysis sequelae in actual patient subpopulations and clinical circumstances. specific aim iv: to evaluate and compare the adhesiolysis-related complications of the laparoscopic and open approaches to adhesiolysis during abdominal re-exploration after prior ventral hernia repair. specific aim v: to determine the comparative effectiveness of the laparoscopic and open approaches to adhesiolysis during abdominal re-exploration after prior ventral hernia repair.


Eligibility criteria:
inclusion criteria: * greater than or equal to 18 years of age * prior ventral hernia repair with intraperitoneal placement of mesh (open or laparoscopic approach; absorbable barrier-coated mesh, permanent barrier-coated composite mesh, permanent barrier-coated noncomposite mesh, non-barrier-coated polypropylene mesh, or biologic mesh) * subsequent abdominal procedure requiring exposure of entire surface area of intraperitoneal mesh exclusion criteria: * less than 18 years of age * inability to verify intraperitoneal mesh type or location * active abdominal wound infection or open abdominal wound

Keywords: hernia adhesiolysis adhesions intraperitoneal mesh abdominal re-exploration mesh barrier-coated mesh non-barrier-coated mesh laparoscopic approach open approach abdominal re-exploration surgery
heparin-induced thrombocytopenia: development and validation of a predictive clinical

Conditions: Heparin-induced Thrombocytopenia

Summary: although heparin-induced thrombocytopenia (hit) is a rare complication of heparin treatment, it results in a high rate of morbidity and mortality, the cumulative rate of thrombosis recurrence, amputation and death approaching 52 % at one month if no specific treatment is initiated. it is therefore vital to diagnose hit as early and as reliably as possible to permit appropriate management of this rare condition. during the acute phase of hit, clinicians and biologists can only suspect this complication with a greater or lesser degree of confidence. clinical data are not sufficiently sensitive or specific to confirm or refute thr diagnosis of hit.

purpose : to create and validate a score predicting the diagnosis of hit

Eligibility criteria:
inclusion criteria: * all patients presenting, either during or immediately after treatment: * thrombocytopenia and/or venous or arterial thrombosis * for whom a request for biological assessment to check for hit (anti-h-pf4 elisa test) is to be addressed to the specialized haemostasis laboratory participating in the study exclusion criteria: * do not possess sufficient clinical data prior to performance of the biological test * cannot assure follow-up of the patient until normalization of the platelet count

Keywords: hit heparin-induced thrombocytopenia heparin treatment venous thrombosis arterial thrombosis predictive clinical score biological test anti-h-pf4 antibodies
acceptance-based self-help for individuals with visible difference and social anxiety

Conditions: Visible Difference; Acceptance and Commitment Therapy; ACT; Skin Condition; Hair Condition; Craniofacial; Burns

Summary: the acceptance and commitment therapy (act) model theoretically fits with treating appearance-related anxiety in individuals with a visible difference. this study examines the effectiveness of an acceptance-based self-help manual for this population.

individuals with visible difference commonly experience social anxiety due to appearance-related concerns. there are limited resources to help people with appearance-related distress, so internet-provided self-help interventions may be beneficial. a pilot randomised controlled trial will compare the effectiveness of an acceptance-based self-help intervention to a waitlist control group. we hypothesise (1) the acceptance-based self-help intervention will significantly increase participants' "psychological flexibility", (2) significantly decrease fear of negative evaluation from others and (3) significantly increase their quality of life, compared to the waitlist control group. data will be collected at two time points only. general distress (core-10) will be collected pre-intervention only to ensure randomisation has been successful. should the two groups significantly differ in distress, this will be accounted for in subsequent analyses.

Eligibility criteria:
inclusion criteria: * individuals who self-identify as having a visible difference to their appearance (such as, but not restricted to: hair and skin conditions, burns, craniofacial conditions, birthmarks, surgical scarring) * must self-define as experiencing concerns about social interaction or a loss of social confidence in relation to their visible difference. * must be aged 18 years or over * must be fluent in english language * must have access to a computer and the internet exclusion criteria: * currently receiving any form of psychotherapy
oral glutamine and mucositis of head and neck cancer patients undergoing radiation

Conditions: Head and Neck Cancer; Mucositis

Summary: this study will enroll 60 consecutive patients who are scheduled to receive radiotherapy with/without chemotherapy due to head and neck cancers. basic data will be recorded along with tumor related variables. then they will be divided randomly into study group and control group. the study group will receive oral glutamine during radiotherapy while the control group will receive placebo during radiotherapy. the severity of oral mucositis (who grading system), pain status (visual analogue scale), quality of life questionnaires will also be documented. the differences between the two groups will be analyzed.

chemotherapy and radiotherapy are important therapeutic modalities for head and neck cancer patients. oral mucositis is a common comorbidity during chemotherapy and radiotherapy. it was reported that 30-60% of patients underwent chemotherapy and over 90% of patients receiving radiotherapy had oral mucositis. oral mucositis not only reduces the quality of life of cancer patients during therapy but also causes dysphagia and poor nutritional status. severe oral mucositis may necessitate unplanned gaps between treatment which can undermine the chance of local control. in terms of management of oral mucositis, maintaining of oral hygiene and avoid infection are essential manner. topical agents such as sucralfate, benzydamine, antifungal drugs, vitamin e and treatment using laser were studied in the management of oral mucositis. previous studies indicated the glutamine significantly reduced the incidence and severity of oral mucositis in patients underwent chemotherapy and bone marrow transplantation. however, few studies discussed the effect of glutamine on the impact of oral mucositis in head and neck cancer patients receiving radiotherapy with/without chemotherapy. this study will enroll 60 consecutive patients who are scheduled to receive radiotherapy with/without chemotherapy due to head and neck cancers. basic data will be recorded along with tumor related variables. then they will be divided randomly into study group and control group. the study group will receive oral glutamine while the control group will receive placebo during radiotherapy. the severity of oral mucositis (who grading system, every week), pain status (visual analogue scale, every week), quality of life questionnaires (before, during and after radiotherapy) will also be documented. the differences between the two groups will be analyzed.

Eligibility criteria:
inclusion criteria: * head and neck cancer patients scheduled to receive radiotherapy with or without chemotherapy exclusion criteria: * prior radiotherapy to the head and neck region * severe liver or renal disease * reye's syndrome * allergy to glutamine * reluctant to join the study

Keywords: head and neck cancer glutamine oral mucositis quality of life
extracorporeal blood purification as a treatment modality for covid-19

Conditions: Covid19

Summary: several studies have suggested a potential clinical benefit of controlling hyper inflammation triggered by sars-cov-2/covid-19. blood purification, the removal of excessive proinflammatory mediators may control disease progression and support clinical recovery. for this purpose, covid-19 patients might benefit from treatment with an69st hemofilter based extracorporeal blood purification.

covid-19 disease progression is associated with dysregulated immunity, commonly referred to as cytokine storm, in particular, aberrant interleukin (il) 6 levels that promote numerous pathological downstream effects. hyperinflammation is a well-established trigger of multiorgan failure, for example, acute kidney injury. moreover, recent reports point to a link between hyper inflammation and covid-19 induced coagulopathy as a result of increased production of clotting factors by the liver. despite several lines of evidence pointing to a potential clinical benefit of controlling hyperinflammation triggered by covid-19, management of covid-19 remains mostly supportive built around continuous respiratory support. to this end, considering the underlying immunological character of covid-19 disease and the high risk of sars-cov-2 hyperinflammation to trigger ards, hypercoagulability and acute kidney injury (aki) this study aims to monitor selected biochemical, immunological and coagulation parameters in combination with radiological imaging to guide clinical practice and to tailor therapy consisting of 1) early initiation of blood purification using the oxiris® (an69st) filter, 2) systemic heparinisation and 3) respiratory support

Eligibility criteria:
inclusion criteria: confirmed covid-19 disease: * rt-pcr * atypical pneumonia; x-ray and/or computed tomography * ≥ 1 oxiris® blood purification cycle exclusion criteria: * pregnancy * heart failure; severe systolic dysfunction, left ventricular ejection fraction \< 25% requiring urgent surgery * aortic aneurysms, dissection or rupture requiring urgent surgery * recent myocardial infarction; cardiovascular disease patients requiring urgent surgery

Keywords: sars-cov-2 cytokine storm interleukin 6 hypercoagulability fibrinogen d-dimer
tele-yoga program in copd and heart failure

Conditions: Yoga; COPD; Congestive Heart Failure

Summary: the combined diagnosis of chronic obstructive pulmonary disease (copd) and heart failure (hf) is common but often missed because of similarities in clinical presentation, risk factors, and patient characteristics. the concurrent presence of both diseases worsens the limitations in exercise capacity and quality of life that patients experience with either disease alone. this pilot study will test the feasibility of a yoga program conducted in patients' homes using multi-point interactive videoconferencing ("tele- yoga") for patients with combined copd/hf diagnoses. the investigators hypothesize that patients who receive a yoga program at home, compared to an educational control group, will experience fewer physical symptoms and better quality of life.


Eligibility criteria:
inclusion criteria: * patients with heart failure (hf) who also have copd according to university of california san francisco medical record documentation and would like to participate in a home yoga intervention and hospitalization within the past 24 months. * patients must: receive permission from their provider to participate in the study * english-speaking * score of 3 on the mini-cog test * be between the ages of 40 and 85 years * new york heart association class i-iii left ventricular systolic or diastolic hf * have moderate-severe copd defined as post bronchodilator forced expiratory volume (fev1) in 1 sec \< 80% predicted, fev1/forced vital capacity ratio \< 70% and history of smoking * tv, broadband internet connection, enough space to practice yoga in front of the tv, and willing to have research assistant install videoconferencing equipment. exclusion criteria: * patients with a history of medication non-compliance as described by their provider * hospitalization within the last 3 months * myocardial infarction or recurrent angina within the last 6 months * severe stenotic valvular disease * history of sudden cardiac death without subsequent automatic internal defibrillator placement * cognitive impairment * neuromuscular, orthopedic, or psychiatric illness that would interfere with yoga training * oxygen saturation \<85% on 6 liters of nasal oxygen.

Keywords: yoga copd congestive heart failure