Kornimate/medical-research-clean huggingface dataset:
study on hemodialysis: illumination effects

Conditions: Sleep Problems

Summary: previous research has shown that sleep quality in hemodialysis patients is disturbed. one of the possible explanations is an insufficient or disturbed melatonin rhythm. melatonin rhythm is regulated by exposure to light. in this feasibility study, the investigators examine the effects of light therapy during dialysis on sleep, melatonin rhythm and mood.


Eligibility criteria:
inclusion criteria: * informed consent * men/women aged 18-85 years * knowledge of the dutch language * hemodialysis patient * subjective sleep problems (epworth sleepiness score \>9) exclusion criteria: * known major illness, which interferes with patient's participation * use of melatonin/hypnotics * use of photosensitizing medication * jet lag or travel \> 1 time zone

Keywords: sleep problems melatonin mood hemodialysis
role of fibrocytes in the bronchial remodelling of chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: airway remodelling is an abnormal tissue repair following bronchial inflammation, which contributes to none reversible pathological features, such as bronchial and peri-bronchial fibrosis. it also influences the prognosis of chronic obstructive pulmonary disease (copd) and its mechanisms remain largely unknown. the role of fibrocytes has been demonstrated in the pathophysiology of asthma, lung fibrosis or pulmonary hypertension. however, the recruitment of blood fibrocytes and their involvement in copd airway remodelling remain unknown. the main objective of the study is to analyse the distribution and quantify the number of the peri-bronchial and blood circulating fibrocytes in patients with different stages of copd compared to control subjects.


Eligibility criteria:
inclusion criteria: * male or female aged more than 40 yr * patient needed a thoracic surgery such as lobectomy for cancer or lung transplantation or lung reduction volume surgery. * copd group: diagnostic of copd and differentiation of the stage from 1 to 4 according to the gold guidelines. * control group: subjects with normal lung function testing and no chronic symptoms (cough or expectoration). subjects will be separated in 2 groups according to smoking history (never smokers, smokers (former or current) and paired to patients according to age and sex. * with a written informed consent exclusion criteria: * subject without any social security or health insurance * asthma, lung fibrosis or idiopathic pulmonary hypertension * chronic viral infections (hepatitis, hiv) * pregnant woman or breastfeeding * subject included for cancer surgery with a pn0 diagnosis not confirmed after the intervention.

Keywords: chronic obstructive pulmonary disease fibrosis fibroblast lung attenuation pletysmography
self-care program in the prevention of admissions of patients

Conditions: Pulmonary Disease, Chronic Obstructive; Heart Failure

Summary: one of the most cost effective intervention is to avoid unnecessary hospitalizations in the national health system. these unnecessary admissions are increasing for several years, reaching rates of over 30% in patients with chronic obstructive pulmonary disease (copd) or heart failure at two months of hospital discharge. there is scientific evidence suggesting that a multidisciplinary intervention consisting in controling disease and stress associated with disease, and modifying eating habits could reduce the number of hospitalizations due to disease decompensation. the main objective of the study is to assess the rate of readmissions at year of multidisciplinary intervention in patients with copd and / or heart failure. we will select 144 patients who will be randomized to two groups (control and intervention group) and they will be followed for 12 months through 4 visits (1 month, 3 months, 6 months and 12 months of hospital discharge). patients assigned to the intervention group will be receive three educational sessions (one of them will be imparted by nursing, another by the nutritionist and the last one by the psychologist). in addition, patients with a bmi \ 30 will receive a closer monitoring by the nutritionist). patients assigned to the control group will receive usual care in clinical practice.


Eligibility criteria:
inclusion criteria: * copd * heart failure: heart failure in clinically stable with ≥ ii degree of nyha . 1 or more emergency admissions for the same diagnosis in the prior year exclusion criteria: * mental states that make difficult the self-care: class 295, 296, 297, 298, 300, 301, 304 and 316 (schizophrenic disorders, episodic mood, delusional other nonorganic psychosis, anxiety, dissociative and somatoform, personality, alcohol and drug dependencies) * congenital respiratory diseases or presence of other obstructive pulmonary diseases * patients participating in other research studies. * other diseases that can affect patients' medium-term survival * moderate to severe cognitive impairment.
neurodegeneration markers and neurological course in severe covid-19 infection

Conditions: COVID-19 Infection; Encephalitis

Summary: emergence of covid-19 virus is associated with high frequency of extremely severe clinical pictures, with minor signs of cns impairment (e.g. anosmia, headache). since neurotropism is a common feature of coronavirus infection in animals, the investigators examine if indirect signs of cns lesion are observed in association with severe covid-19 infection.

in animals, coronavirus infection is commonly associated with cns involvement: epilepsy and ataxia are observed during feline infectious peritonitis (fip) and virus is recovered in csf, cns is involved with strain-dependent severity in mice and rats infected by murine hepatitis virus, and murine infection with mhv a59 strain is a model of multiple sclerosis (ms). mice encephalitis occurs through infection of olfactory bulb and spreads along the axonal pathway. viral antigens and neuronal apoptosis are observed in brainstem and hypothalamus, without minimal or absent inflammation. most covid-19 patients with neurologic impairment displayed expected complications of severe infections (e.g. neuropathy and muscle loss, stroke) but encephalitis remained exceptional, as previously observed in sras. it is argued that central lesions may explain some of the clinical features ventilation failure, or disproportionate residual fatigue and cognition impairment in survivors of severe covid infection. according to data obtained from various coronavirus infections in animals, the investigators ask if severe covid infection in human could be associated with sub-clinical encephalitis. this clinical trial examines highly sensitive blood biomarkers of brain dysfunction in correlation with late clinical outcome. biomarkers are neurofilament light chain (nfl) and gfap. clinical outcomes are death, signs of central neurologic sequellae, and fatigue. clinical examination and blood samples will be obtained at inclusion (d0), which is mostly the entrance in intensive care unit (icu), at day 7 (between day 4 and exit from icu) and at day 60.

Eligibility criteria:
inclusion criteria: * infection with covid-19 (proven or probable) and * possible encephalitis (at least confusion, epilepsy) or * clinical severity requiring invasive ventilation. exclusion criteria: * brain stroke * minor cns dysfunction (isolated smell loss or headache), * absence of covid infection.

Keywords: covid-19 encephalitis biomarkers neurofilament protein light gfap protein
sharing our strength: a research study for bone marrow/stem cell transplant survivors

Conditions: Leukemia; Acute Leukemia; Acute Lymphocytic Leukemia; Multiple Myeloma; Hematological Cancers; Psychological Distress

Summary: the sharing our strength study is being conducted to help us understand people's experiences with hematopoietic stem cell transplantation and to test a new program designed to help people recover physically and emotionally after transplant.

this is a study for survivors of hematopoietic stem cell transplantation (also known as bone marrow transplant), which is an intensive medical treatment for cancers such as leukemia, lymphoma, and multiple myeloma as well as other diseases. because it is a physically and emotionally demanding treatment, many people report having ongoing physical and emotional difficulties after having a transplant. the sharing our strength study is being conducted to help us understand people's transplant experiences and to test a new program designed to help them recover physically and emotionally after transplant. all parts of the study are completed by mail and telephone. participants will receive compensation for their time.

Eligibility criteria:
inclusion criteria: * be a transplant survivor who is 9 months to 3 years beyond transplant and not currently relapsed. and not currently relapsed * be at least 18 years old now (and at least 16 when they had their transplant) * speak english * have telephone service exclusion criteria: * none

Keywords: aplastic anemia lymphatic diseases leukemia leukemia, lymphoid immunoproliferative disorders precursor cell lymphoblastic leukemia-lymphoma anemia quality of life lymphoproliferative disorders lymphoma multiple myeloma
a study of xuebi formula for diabetic peripheral neuropathy(qi-deficiency and blood-stasis)

Conditions: Diabetic Peripheral Neuropathy; Diabetes; Chinese Herbs

Summary: a randomized, parallel-controlled, clinical study to evaluate the efficacy of xuebi prescription compared with placebo in the treatment of diabetic peripheral neuropathy(qi deficiency and blood stasis)

charged by the sponsor in line with traditional chinese medicine qi deficiency and blood stasis syndrome 60 cases have dpn，they were randomly divided into chinese herbal compound xuebi prescription group and placebo group. the treatment groups were compared 24-week composite score.

Eligibility criteria:
* according to the 1999 who criteria, in accordance with the diagnostic criteria for type 2 diabetes. * according to the diagnostic standard of diabetes peripheral nerve lesions. * age range 30-70 years. * syndrome of traditional chinese medicine is qi deficiency and blood stasis. * fbg \< 13.9mmol/l, hba1c\<10%. * signed the informed consent exclusion criteria: * did not meet the inclusion criteria, or incomplete information affect the clinical syndrome differentiation type; * repeated hypoglycemia reaction, nearly a month diabetic ketoacidosis, dkaand severe infections; * blood pressure without control or after control, sbp ≥ 160mmhg or (and)dbp ≥ 100mmhg; * tg≥ 5.6mmol / l; * diabetic lower extremity vascular disease (resting ankle brachial index in patients with abi ≤ 0.90 or lower extremity ultrasound vascular stenosis \> 50%). * pregnancy, to pregnant or lactating women; * the ingredients allergy of chinese herbal medicine and allergic constitution person; * psychiatric patients; * have serious heart, lung, liver, kidney, brain and other complications overassociated with other severe primary diseases; * other patients had participated in clinical trials or are in other clinical trials before the test in january; * in the past 5 years with alcohol and / or psychoactive substances, drug abuse and dependence; * according to the researcher's judgment, can reduce the possibility of the group or other diseases or conditions were complicated, such as work environment change frequently, the living environment is not stable, easy to cause lost * hepatic, renal impairment (alt, ast is greater than 2.5 times the upper limit of normal value; serum creatinine greater than 1.5 times the upper limit of normal value); * demyelinating lesions or from other causes of polyneuropathy patients.
prevalence of hyperuricemia in pakistan

Conditions: Hyperuricemia

Summary: the prevalence of hyperuricemia has rarely been investigated in developing countries hyperuricemia, or raised serum uric acid (sua), is the condition closely associated with gout due to the deposition of monosodium urate crystals in peripheral joints and soft tissues. hyperuricemia is associated with an increased risk for incident hypertension, independent of traditional hypertension risk factors. this risk appears more pronounced in younger individuals and women. cross-sectional studies show an association of hyperuricemia with the presence of ckd. insulin resistance plays a potentially key role in the causal relationship between metabolic syndrome, type 2 diabetes and hyperuricemia. furthermore, it is likely that hyperuricemia and insulin resistance share a bidirectional causal effect. the rationale of this study is to determine prevalence of hyperuricemia in pakistan.

informed consent will be obtained from all patients and their attendant coming to clinics. those who will agree to be part of this study were asked a questionnaire about co-morbidity and symptoms. uric acid levels will be assessed by using uasure blood uric acid monitoring system. male with uric acid levels greater than 7 mg/dl and female greater than 6 mg/dl were classified as hyperuricemia.

Eligibility criteria:
inclusion criteria: * informed consent given exclusion criteria: * no informed consent provided

Keywords: uric acid prevalence pakistan
micronutrient supplementation in children with asd

Conditions: Autism Spectrum Disorder

Summary: an open-label examination of changes in metabolites with use of micronutrients in children with autism spectrum disorder (asd). investigators will also measure behavioral measures monthly at school with teachers and parents report.

children enrolled in oak hill school will enroll in this study and take micronutrient supplement once a day for 8 weeks period. behavioral measures and metabolites taken from dried blood spots (dbs) will be collected pre and post treatment. behavioral measures will be taken again at 12 weeks, after 4 weeks of not dosing.

Eligibility criteria:
inclusion criteria: 1. male or female, enrolled at oak hill school (ohs), age 6-22 and with a diagnosis of asd. 2. asd diagnosis will be established by standard criteria (dsm-iv criteria and expert clinician review of medical records and child observation). 3. written informed consent obtained from the subject's legal representative and ability for subject to comply with the requirements of the study. exclusion criteria: 1. presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data. 2. taking multivitamins currently and unwilling to stop during the study period
research study for patients with metastatic renal cell carcinoma

Conditions: Carcinoma, Renal Cell

Summary: this study has been designed to study patients diagnosed with advanced renal cell cancer with the primary tumor in place.


Eligibility criteria:
inclusion criteria: * life expectancy of at least 12 weeks * clinical, radiographic, or pathologic diagnosis of metastatic renal cell carcinoma (rcc). all renal cell histologies are allowed- acceptable surgical risk in the judgment of the study investigator and consulting urological surgeon * at least one uni-dimensional measurable lesion outside the planned nephrectomy specimen * patients who have an ecog performance status of 0 or 1 exclusion criteria: * history of bleeding diathesis or unexpected surgical bleeding- patients currently receiving treatment with or having a requirement for therapeutic anticoagulation * prior therapy for rcc. palliative radiation therapy for painful or unstable bone metastases is permitted provided that there is measurable metastatic disease outside the radiation field * known history of hiv infection- symptomatic metastatic brain or meningeal tumors, unless the patient is \> 6 months from definitive therapy, has a ct or mri scan within 6 weeks of study entry negative for brain metastases and is clinically stable with respect to the tumor at the time of study entry

Keywords: cancer
the effect of developing psychological resilience on functionality in schizophrenia patients

Conditions: Schizophrenia

Summary: people with schizophrenia have low functionality and psychological resilience. psychological resilience of individuals can be improved. the funcionality of individual with improved psychological resilience can also be improved. therefore, both resilience and functionality can be increased by appliying resilience programs to patients with schizophrenia.

the aim of study is to determine the effect of the resilience development program applied to schizophrenia patients on the resilience and functionality of the patients. experimental research design with pretest posttest control group will be used in the study. 36 patients receiving service from a community mental health center will be included in the study (determined by "power analysis"). 18 people will be included in the experimental group and 18 people in the control group (random appointment will be made by drawing lots). the data of the study will bu collected with "personal information form", "adult resilience scale", "short functionality assessment scale" and "beck cognitive insight scale - for schizophrenic patients". consent will be obtained from the individuals participating in the study before the study. an "ethics commitee approval certificate" will also be obtained before starting the study. "resilience development program" based on cognitive behavioral approach developed by the researcher will be applied to the experimental group. spss 28.0 program will be used in the analysis of the data. mean, standard deviation, median, minimum and maximum values will be used in the descriptive statistics of the data. mann whitney u test, chi-square test and wilcoxon test will be used in the analysis of quantitative independent data.

Eligibility criteria:
inclusion criteria: * be at least literate * be in remision * not have mental retardation, hearing and speech problem exclusion criteria: * those in acute exacerbation * those with other psychiatric illnesses * those who are / have attended a similar training program

Keywords: schizophrenia development resilience resilience functionality cognitive behavioral
continuous positive airway pressure effect on air trapping in chronic obstructive pulmonary disease patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease is a disease characterized by small airways inflammation and obstruction. the small airways disease produces hyperinflation (air trapping), which increases with exercise. continuous positive airways pressure may reduce small airways obstruction and therefore air trapping. pulmonary function tests including lung volumes at rest and and after exercise will be measured. in addition, exercise endurance time before treatment and after treatment will be measured.

continuous positive airways pressure which prevent small air ways collapse and may also clear secretions. at first stage the optimal pressure for reducing air trapping will be determined. in addition, all patients will undergo a maximal exercise test. a baseline complete pulmonary function test is performed followed by continuous positive air way pressure at the pre-determined pressure. this will be followed by exercise at 60% of maximal obtained previously.

Eligibility criteria:
inclusion criteria: * chronic obstructive lung disease stage 2-3 gold * frc \> 120% exclusion criteria: * active ischemic heart disease * heart failure * peripheral vascular disease

Keywords: copd cpap sham fev1 ic rv/tlc
effectivity and safety of endoscopic ultrasonography-guided laser ablation for refractory neoplasms

Conditions: Refractory Neoplasms

Summary: the purpose of this study is to evaluate the safety and efficacy of endoscopic ultrasonography (eus) guided laser ablation liver, pancreas, and retroperitoneal tumors, the investigators used preoperative and postoperative us/ceus/ct/mri to assess lesions, and laboratory tests including the tumor markers to evaluate the general condition of patients. intraoperative us/ceus/ct would be applied to monitor ablation lesions.


Eligibility criteria:
inclusion criteria: * patients with refractory neoplasms including small hepatocellular carcinoma adjacent to the gastrointestinal tract, pancreatic neuroendocrine tumor, retroperitoneal tumor with less than 3 cm in diameter; * patients with child-pugh a/b; * patients with plt ≥ 50\*10e9/l and pt ≤ 20s. exclusion criteria: * patients with severe cardiopulmonary disease, intolerant endoscopy and anesthesia, upper gastrointestinal bleeding in shock, corrosive esophagitis and acute gastritis.

Keywords: endoscopic ultrasonography laser ablation
community opioid innovation network (jcoin): tcu clinical research center

Conditions: Addiction, Opioid

Summary: there are two study periods for the tcu jcoin project. the primary aims of study 1 (approved by the tcu irb) are (1) to gather information from staff on the current treatment referral process within participating communities and (2) to learn about the existing interrelationships between medical and community behavioral health (cbh) providers. tcu irb granted approval for phase 1 on 11/07/19, approval number: 1920-60-am1. study 2 (under current review by the tcu irb) includes recruitment across 18 community collaboration sites across 3 states; these communities will participate in the tcu opioid-treatment linkage model (o-tlm) protocol. the o-tlm is focused on best practices for improving screening, identifying and linking to moud providers, reducing stigma, and addressing other important factors that impact justice-involved individuals returning to their communities. along with their agency records, information collected from justice-involved individuals within the target communities will be examined to assess o-tlm impact on improving public health and public safety outcomes. furthermore, stakeholder staff across community organizations, including criminal justice and treatment agencies, will be asked to complete surveys on the o-tlm regarding its acceptability and adoption, as well as on best training strategies.


Eligibility criteria:
inclusion criteria: * client level participant eligibility includes having a history of opioid use or at risk for opioid use; being released to a participating community while under supervision * staff level participant eligibility includes being a key member of a participating community and involved in the service assessment and referral process of justice-involved individuals. exclusion criteria: * no history of opioid use or being at risk of opioid use; not being released to a participating community. * staff level participant exclusion criteria include not being a key member of a participating community and not being involved in the service assessment and referral process of justice-involved individuals.
diet, genetic variation and prostate cancer among african americans

Conditions: Prostate Cancer

Summary: this is a single center pilot study to asses the feasibility of conducting a larger population-based study. it is an investigator-initiated study funded yb the uc davis cancer center's development award program. the hypothesis is that the percent african ancestry in an individual may determine their prognosis if diagnosed with prostate cancer.


Eligibility criteria:
inclusion criteria: self-identification as a male with african ancestry between ages of 35-75 exclusion criteria: no african ancestry not between ages of 35-75 -

Keywords: prostate cancer