Kornimate/medical-research-clean huggingface dataset:
assessment of strategies for the management of flu-like symptoms in ms patients commencing treatment with betaferon (influence)

Conditions: Multiple Sclerosis

Summary: this will be prospective, multicentre, observational study. patients who will initiate treatment with ifnβ-1b (betaferon) will be followed up to 6 months. baseline visit (visit 0) i.e. treatment initiation plus four follow-up visits (visits 1-4). for each patient demographics, medical history data, safety parameters, presence of flu-like symptoms and measures to prevent or treat these symptoms will be collected.


Eligibility criteria:
inclusion criteria: * diagnosis of relapsing-remitting multiple sclerosis (rrms) according to mcdonald (2005) criteria * age \>/= 18 years old * treatment ms patients in whom the attending physician has decided to initiate therapy with interferon beta-1b; betaferon * minimum 6 months wash-out period from previous ifnβ * written informed consent signed exclusion criteria: * patients previously treated with any of the disease modifying drugs (dmds), with the exception of ifnβ therapy which ended at least 6 months earlier * patients receiving treatment with ifn beta other than betaferon (bayer)

Keywords: multiple sclerosis (ms) interferon
validation of the neurotec loft

Conditions: Neurodegenerative Diseases; Activities of Daily Living; Aging

Summary: the progression of neurodegenerative disorders and the increasing number of elderly people intensifies the need of institutional care, which contrasts with the desire of most elderly and patients to live independently at home. the rapid evolution of assistive technology offers new possibilities in providing medical professionals preventive services in real-time. therefore, the main focus of this study is on the individual sensors and how they can be combined to one unobtrusive system to assess the human behaviour and daily activities during day and night in an instrumented apartment in healthy participants.

the higher prevalence of age-associated neurodegenerative disorders (e.g. parkinson, alzheimer), is in line with a steady increase of the average life expectancy in switzerland. with the progression of neurodegenerative disorders and the increasing number of elderly people, the need for institutional care intensifies, which contrasts with the desire of most elderly and patients to live independently. the rapid evolution of assistive technology offers new possibilities in providing medical professionals preventive services in real-time. an extended stay in the hospital could influence independent ageing negatively and thus, monitoring has great potential to prevent critical events. in this study, the main focus is on the individual sensors and how they can be combined to one unobtrusive system. in addition, to get an understanding which parameters of the sensors are important and how the data can be extracted and processed (algorithms). therefore, the aim of this study is to validate the accuracy to assess human behaviour and daily activities during day and night by unobtrusive sensors in an instrumented apartment in healthy participants.

Eligibility criteria:
inclusion criteria: * written informed consent * aged ≥18 years * german speaking exclusion criteria: * infected by multidrug-resistant bacteria according to current medical history * incontinence
pilot study of ketamine in adults with obsessive-compulsive disorder (ocd)

Conditions: Obsessive-Compulsive Disorder

Summary: in this study investigators are studying the effects of a drug called ketamine on the symptoms of obsessive-compulsive disorder (ocd).

obsessive-compulsive disorder (ocd) is a common psychiatric illness that affects up to 2-3% of the population. people with ocd experience anxiety-provoking, intrusive thoughts, known as obsessions, and feel compelled to perform repetitive behaviors, or compulsions. the only medications proven effective for ocd are serotonin reuptake inhibitors (sris), but even with sri treatment, most patients continue to experience significant ocd symptoms, impaired functioning, and diminished quality of life. recent evidence suggest that a different neurotransmitter, glutamate, may contribute to the symptoms in ocd. medications that target glutamate hold promise for ameliorating symptoms for those patients continuing to suffer from ocd. in this study the investigators are recruiting patients to receive the drug ketamine, which is thought to modulate the neurotransmitter glutamate through the n-methyl-d-aspartate (nmda), in a 2-week placebo controlled study.

Eligibility criteria:
inclusion criteria: * age 18-55 * physically healthy and not currently pregnant * primary diagnosis of ocd * sufficient severity of symptoms * able to provide consent exclusion criteria: * psychiatric conditions that make participation unsafe * currently on psychotropic medication * medical conditions that make participation unsafe * allergy to ketamine * any metal in the body

Keywords: ocd
futibatinib in patients previously enrolled in an antecedent futibatinib as monotherapy or combination therapy.

Conditions: Advanced/Metastatic Cancer

Summary: this is a nonrandomized, open-label, multicenter rollover study for patients who received futibatinib as monotherapy or as combination therapy in a taiho-sponsored futibatinib study.

tas-120-404 is a nonrandomized, open-label, multicenter rollover study for patients who received futibatinib as monotherapy or as combination therapy in a taiho-sponsored futibatinib study. patients who are still receiving futibatinib as monotherapy or as combination therapy, are deriving clinical benefit with no undue risk as assessed by the investigator, and have not met any of the antecedent protocol-specific discontinuation criteria are eligible to participate.

Eligibility criteria:
inclusion criteria: * provide written informed consent. * receiving futibatinib as monotherapy or as combination therapy in an antecedent futibatinib study and deriving clinical benefit with no undue risk as assessed by the investigator. * women of childbearing potential (wocbp) must have a negative pregnancy test (urine or serum) within 7 days prior to receiving treatment. both males and females of reproductive potential must agree to use effective birth control during study treatment and for a specified time after the last dose of study treatment. * ability to take medications orally (po) (feeding tube is not permitted). exclusion criteria: • has met any discontinuation criteria within the antecedent futibatinib study.

Keywords: futibatinib tas-120 fgfr cholangiocarcinoma breast cance urothelial carcinom
intra-op detection of occult ovarian carcinoma using a folate-alpha receptor specific fluorescent ligand

Conditions: Ovarian Cancer

Summary: prognosis for many carcinomas, including ovarian carcinoma, is dependent on a complete surgical resection, also known as a r0 resection. at present, the ability to perform a complete resection with negative margins is limited by the surgeon's ability to palpate and visualize the tumor and its margins. therefore, in order to reduce operative morbidity and costs while maintaining or improving surgical and oncologic outcomes, the investigators must develop technologies that improve visualization of the primary tumor and occult metastases, real time, during surgery. recent research has demonstrated that the use of fluorescent probes that recognize cancer specific antigens can be used for this purpose when visualized using a prototype near-infrared multispectral imaging system. this investigation will determine if folate-fitc, a fluorescent probe that recognizes the folate receptor (present in \> 90% of ovarian cancers) can facilitate surgical resection and detect tumor nodules not visible to the naked eye.


Eligibility criteria:
inclusion criteria: women who are: * diagnosed with or at high clinical suspicion of primary ovarian cancer by either radiologic imaging or physical examination or biopsy or serum tumor markers * scheduled to undergo surgical cytoreduction via laparotomy * at least 18 years of age * capable and willing to provide informed consent exclusion criteria: women with: * known sarcomatous histologies * recurrent ovarian cancer * planned surgical approach via laparoscopy or robotic surgery * a history of anaphylactic reactions to folate-fitc or insects * inability or unwillingness to provide informed consent

Keywords: ovarian cancer
a 10-minute cardiovascular magnetic resonance protocol for cardiac disease

Conditions: Coronary Artery Disease; Myocarditis; Infiltrative Cardiomyopathy; Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy; Aortic Valve Stenosis; Aortic Valve Regurgitation; Pericardial Effusion; Congenital Heart Disease; Vascular Anomaly

Summary: this study aims to identify and assess new cmr techniques that can improve current cmr protocols.

the aim of this study is to develop a comprehensive 10-minute protocol based on function and myocardial tissue characterization without the need for contrast injection, which can be standardized for 70% of cardiac patients. to test this 10-minute cmr protocol for its ability to significantly improve diagnostic decision-making and to reduce cost. to test its clinical feasibility, performance and cost-effectiveness in different populations including: non-ischemic cardiomyopathies (-)os-cmr and ischemic heart disease and cad (+)os-cmr

Eligibility criteria:
healthy volunteers inclusion criteria: * age: \> 18y, informed consent no known current or pre-existing significant medical conditions that would affect the cardiovascular or respiratory system exclusion criteria: * general mri contraindications: mr- incompatible devices such as pacemakers, defibrillators, or implanted material or foreign bodies. consumption of caffeinated drinks or foods (including cocoa and chocolate) during the 12 hours prior to the exam.regular nicotine consumption during the last 6 months patients inclusion criteria: * age: \>18 y, informed consent, clinically indicated cmr exam exclusion criteria: * general mri contraindications: mr- incompatible devices such as pacemakers, defibrillators, or implanted material or foreign bodies vasoactive medication (e.g. nitro) during the 12 hours prior to the exam. consumption of caffeinated drinks or foods (including cocoa and chocolate) during the 12 hours prior to the exam. regular nicotine consumption during the last 6 months
the effects of continuous passive motion on hypertonia of soleus in individuals with cerebral palsy

Conditions: Cerebral Palsy (CP)

Summary: cerebral palsy (cp) is a group of disorders of the development of movement and posture but often changing motor impairment syndromes. the spastic subtypes are the most common manifestations of cerebral palsy who perform movement difficultly due to hypertonia. decease of spinal cord pathway, hyperactivity of alpha and gamma motoneuron and reduction of presynaptic inhibition may cause tendon reflex increase and hypertonia in individuals with cp. there are many ways to improve the hypertonia. in the past studies, the fast repeated range of motion could reduce muscle's activation effectively. the polyarticular movement training might increase joint range of motion and reduce the muscle activation. but the polyarticular movement training is difficulty for some individuals with cp. the single joint movement training may achieve the same effect as the polyarticular movement training. the purpose of this study was to investigate the effects of continuation passive range of motion (cpm) training whether could get the improvement of soleus hypertonia in individuals with cp.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of spastic cp * modified ashworth scale of soleus \> 1 * ankle range of motion \> 10 degrees exclusion criteria: * fracture on lower lower extremities * botox on ankle \< 5 mouths

Keywords: cerebral palsy continuous passive motion hypertonia
platelet count and function after usage of two different cell saver devices during liver transplant surgery

Conditions: Liver Transplant; Hemorrhage, Surgical

Summary: intraoperative cell salvage is commonly used in surgeries that carry a major hemorrhagic risk to reduce the administration of allogeneic red blood cells and thus improve the outcome for the patient. when processing the salvaged blood, however, a large part of the patient's plasma is washed out. this is a disadvantage with regard to an optimal coagulation status after these types of surgeries, especially liver transplantation. there are currently various cell saver systems on the market. according to the manufacturers, the plasma is returned to the patient in different quantities as part of the processing procedure. thus, it can be assumed that in addition to red blood cells, platelets (part of plasma) are re-transfused and contribute to an optimized coagulation. unfortunately, there is a lack of studies in this regard in the liver transplant surgery population. the investigators aim to study the performance of two different cell saver devices regarding preservation of platelet number and function.

- study design: randomized controlled bi-center trial * primary objective: to compare platelet number and function after processing and re-transfusion of the salvaged blood to the patient by using different cell saver devices. * secondary (main) objectives: to compare a) the coagulation profile and b) the usage of blood products (frequency of administration of labile and stable blood products).

Eligibility criteria:
inclusion criteria: * all adult patients undergoing liver transplantation surgery exclusion criteria: * age \< 18 years old * active liver malignancy * preoperative use of oral or intravenous anti-coagulants or antiplatelet agents (except aspirin) * inability to understand and sign the informed consent form
pharmacogenetics of gastrointestinal bleeding

Conditions: Gastrointestinal Hemorrhage; Stomach Ulcer; Non-steroidal Anti-inflammatory Drug Sensitivity

Summary: gastrointestinal bleeding is a severe adverse effect occurring in subjects secondary to the use of nonsteroidal anti-inflammatory drugs (nsaids). the enzyme cyp2c9 is responsible for the elimination of several nsaids. this protein is inactive in 12% of the subjects because of genetic mutations. we hypothesized that individuals carrying such mutations should be at higher risk of gastrointestinal bleeding since they display decreased nsaids elimination.

gastrointestinal bleeding is a severe adverse effect occurring in subjects secondary to the use of nonsteroidal anti-inflammatory drugs (nsaids). the enzyme cyp2c9 is responsible for the elimination of most nsaids. several polymorphisms have been observed in cyp2c9. of these, the cyp2c9\*3 allele, found in 12% of caucasian subjects, leads to reduced function of the enzyme. we hypothesized that individuals carrying this mutation should be at higher risk of gastrointestinal bleeding since they display decreased elimination of some nsaids. the purpose of this study is to determine whether the frequency for cyp2c9\*3 variant allele is increased in subjects using nsaids metabolized by cyp2c9 in comparison with subjects under nsaids not metabolized by this enzyme. the study groups consist of 200 patients suffering from gastrointestinal bleeding after nsaids use, divided in 100 patients using nsaids metabolized by cyp2c9 and 100 patients using other nsaids.

Eligibility criteria:
inclusion criteria: * upper gastrointestinal bleeding revealed by hematemesis, melena or lowering of at least 2g/dl of haemoglobin * endoscopic report of gastrointestinal ulcer or haemorrhagic lesion * immediate antecedents of nsaid therapy exclusion criteria: * cirrhosis (child b or c) * coma * concomitant therapy with substrates or inhibitors of cyp2c9 : ketoconazole, itraconazole, ritonavir, phenobarbital, rifampicin, depakine, phenytoin, st john's worts * patients treated by a nsaid metabolized by cyp2c9 and a nsaid not metabolized by cyp2c9

Keywords: gastrointestinal haemorrhage stomach ulcer anti-inflammatory agents, non-steroidal cyp2c9 protein, human genotype pharmacogenetics
glucosamine sulphate, ginger, ginger-avocado-soya and ginger-ibuprofen for chronic back pain

Conditions: Back Pain

Summary: the main purpose of this study is to investigate the ability of some dietary supplement products to affect general joint health and life quality in a selected population with back pain. the study is randomized and double - blind, with parallel groups receiving treatment for a duration of 12 weeks.


Eligibility criteria:
inclusion criteria: * chronic back pain daily or almost daily for at least 3 months prior to inclusion * patient classified as i or ii according to quebec task force * no intake of glucosamine sulphate, ginger, or avocado-soya extract during last 3 months * fertile women should, at start, have a negative pregnancy test and during test use acceptable prevention methods (p-pills, intrauterine device \[iud\], depot gestagen, subdermal implant, hormonal vaginal ring or transdermal depot plaster). * anxiolytics, muscle relaxants, physiotherapy, chiropractic treatment, or training should not have been used during last 3 months. exclusion criteria: * serious disease (eg. heart disease, cancer (within past 5 years), kidney disease, blood diseases, inflammatory diseases (eg. chronic rheumatoid arthritis, fibromyalgia) * suspicion that back pain is caused by osteoporosis, other arthritic condition than osteoarthritis, cancer, infection, pain from organ disease or psychosomatic cancer disease. * uncontrolled elevated blood pressure, defined as systolic ≥ 160 mm hg or diastolic ≥ 90 mm hg. * vas measurement at inclusion less than ved 30 mm or over 90 mm. * prehistory of ulcer, stomach surgery, or inflammatory bowel disease * pain relief medication besides must not be taken during study. * patients in need of non-steroidal anti-inflammatory drugs (nsaids), morphine, or similar medication are not eligible. same is also valid for patients in need of injections or acupuncture. * back surgery within 6 months before inclusion or earlier surgery without effect * "heart" aspirin (low dose), ulcer medication, or blood thinning medication * alcohol abuse * depression * pregnancy or breastfeeding * allergy to crustaceans or known intolerance for glucosamine sulphate, ginger, avocado, soy, or ibuprofen * allergy or asthma released by salicylic acid or other arthritis medication (nsaids) * patient who is seeking pension due to back pain or has other economical interests connected to his/her back pain

Keywords: back pain
safety of patanase nasal spray in patients with perennial allergic rhinitis

Conditions: Perennial Allergic Rhinitis

Summary: the purpose of this study was to assess local nasal adverse effects, as well as systemic effects, of patanase nasal spray when compared with patanase vehicle, ph 3.7 and patanase vehicle, ph 7.0 in patients with perennial allergic rhinitis (par).


Eligibility criteria:
inclusion criteria: 1. sign informed consent; 2. normal nasal exam; 3. history of perennial allergic rhinitis; 4. allergy to perennial allergen documented by allergy testing; 5. age 12 years and older; 6. must follow instructions; 7. must make required study visits; 8. negative pregnancy test and adequate birth control methods for females of childbearing potential; 9. refrain from certain allergy medications during the study; 10. other protocol-defined inclusion criteria may apply. exclusion criteria: 1. nasal disorders; 2. use of substances that affect the nasal septum; 3. exposure to industrial metal plating solutions; 4. uncontrolled, severe, or unstable diseases; 5. hypersensitivity to the study drug or nasal spray components; 6. relative of site staff with access to the protocol; 7. participation in another investigational study within 30 days or at the same time as this study; 8. medical monitor decision; 9. other protocol-defined exclusion criteria may apply.

Keywords: nasal allergy nasal spray seasonal allergy perennial allergy
the effect of dexmedetomidine on decreasing emergence agitation and delirium in pediatric patients undergoing strabismus surgery

Conditions: Strabismus

Summary: postoperative agitation in children is a well-documented clinical phenomenon with incidence ranging from 10% to 67%. recently, dexmedetomidine has been investigated extensively in the pediatric population and there is now increasing evidence to support the use of this drug as sedative and anesthetic adjunct in children. the purpose of this study is to determine whether prophylactic use of intraoperative dexmedetomidine to prevent of emergence delirium.


Eligibility criteria:
inclusion criteria: * the patient undergoing the strabismus surgery in severance hospital exclusion criteria: * delayed development * mental retardation * cerebral palsy * preoperative ekg abnormality e.g. cardiovascular conduction disorder
frailty and associated factors in lumbar spinal stenosis

Conditions: Lumbar Spinal Stenosis

Summary: lumbar spinal stenosis (lss) is generally seen with advanced age, but it manifests itself with an increase in both physical and psychological health problems. frailty is an important parameter that has become increasingly important in recent years and affects both the physical and psychological health of individuals. it has been examined in various disease groups in the literature and is reported to increase in patients with low back pain. however, the level of frailty and related factors in lss are unknown. since physical and psychological health are important in maintaining daily life, it is important to examine frailty in these individuals who present with chronic pain symptoms.

lumbar spinal stenosis (lss) is a degenerative disease that occurs due to compression of neurological structures as a result of narrowing of the spinal canal, and is particularly common in elderly individuals. lss is characterized by pain, neurogenic claudication, decreased walking capacity, and functional disability. this condition can limit patients' daily living activities, leading to decreased physical activity levels, balance disorders, and increased fear of falling. at the same time, disability and decreased quality of life due to the disease can negatively affect individuals' physical and psychosocial health status, leading to increased frailty levels. frailty is an important geriatric concept that requires multidisciplinary approaches and is associated with increased dependency and risk of falling in elderly individuals. demonstrating the relationship between frailty and parameters such as pain, disability, quality of life, physical activity, balance, and fear of falling in individuals with lss can contribute to the development of more effective rehabilitation strategies for the management of the disease.

Eligibility criteria:
inclusion criteria: * patients diagnosed with lumbar spinal stenosis by mri, * patients between the ages of 45-80, * patients who can stand independently, * volunteer to participate in the study exclusion criteria: * patients who did not agree to participate in the study, * those with a chronic disease that would affect walking, * those who had undergone surgery in the lumbar region within the last year, * those with advanced joint disease in the lower extremity, * those with malignancy in the spine, * those with vision and/or vestibular system problems, * those who did not cooperate well were not included in the study.