Kornimate/medical-research-clean huggingface dataset:
diffusion-weighted imaging magnetic resonance for assessing liver fibrosis

Conditions: Fibrosis, Liver

Summary: several noninvasive radiological techniques have been investigated for the diagnosis of liver fibrosis and cirrhosis among patients with chronic infection with hepatitis b virus or hepatitis c virus. diffusion-weighted magnetic resonance imaging (dw-mri) is a particularly appealing method for the diagnosis of liver fibrosis. the aims of this study are to evaluate the accuracy of dw-mri in patients with chronic viral hepatitis for determining the stage of liver fibrosis.

among patients with chronic infection with hepatitis b virus or hepatitis c virus, evaluation of the stage of liver fibrosis is of major importance for determining prognosis and therapeutic decisions. liver biopsy is a costly and invasive technique with associated mortality and morbidity. a typical biopsy fragment represents only 1/50,000 of the organ. several noninvasive radiological techniques have been investigated for the diagnosis of liver fibrosis and cirrhosis. diffusion-weighted magnetic resonance imaging (dw-mri) is a particularly appealing method for the diagnosis of liver fibrosis. because it is easy to implement, non-operator dependent, and process without the need for contrast agents. however, preliminary studies on small numbers of patients in which various hardware and sequencing profiles were used have reported inconsistent results for staging liver fibrosis with dw-mri. the aims of this study are to evaluate correlation between stage of hepatic fibrosis and liver apparent diffusion coefficient (adc) and normalized liver adc with spleen assessed by dw-mri in patients with chronic viral hepatitis b or c. also, this study aim to evaluate factors that influence liver adc and normalized liver adc with spleen value for predicting the stage of liver fibrosis as well as to estimate the optimal cutoff values of dw-mri for determining significant liver fibrosis (fibrosis stage ≥2) and advanced fibrosis (fibrosis stage ≥3).

Eligibility criteria:
inclusion criteria: * all naive patients with chronic hepatitis b or c infection who undergo liver biopsy examination for evaluating candidates for antiviral therapy will be invited to participate into this study exclusion criteria: * other cause of chronic liver disease * contraindication for liver biopsy * contraindication for magnetic resonance imaging

Keywords: hepatitis b hepatitis c fibrosis, liver magnetic resonance imaging
dietary diversities: exploring the influence of keto diet and intermittent fasting on oral health and salivary inflammatory biomarkers

Conditions: Gingivitis

Summary: this study aims to investigate the impact of short term, two distinct dietary interventions, namely the keto diet and intermittent fasting on oral health by measuring the severity of: * periodontal diseases (gingivitis). * oral health status (plaque index). as well as measuring the impact of these different dietary pattern on the levels of c- reactive protein, il-6, tnf-a in mean of inflammatory biomarkers as well as ll- 37 peptide as well as measuring salivary flow and ph. objectives of the study 1. evaluate the impact of keto diet and intermittent fasting on oral health among the iraqi population. 2. assess changes in inflammatory biomarkers within the study groups before and after the intervention period. 3. compare the effects of keto diet and intermittent fasting on oral health and inflammatory biomarkers between the two intervention groups. 4. examine the variations in oral health and inflammatory biomarkers within each group by comparing the baseline (iraqi diet) and post-intervention stages. 5. investigate the influence of keto diet and intermittent fasting on the levels of ll37, an antimicrobial peptide.


Eligibility criteria:
inclusion criteria: * adults in good general health with a bmi in the range of 19-30 kg/m2 (overweight and obese cl i). * age 20-35 years. exclusion criteria: * low-carbohydrate nutrition already prior to the study. * impaired liver and renal function, kidney stones. * pregnancy or lactation period * diabetes mellitus and any fatty acid-metabolism disorders. * presence of systemic disease (diabetes, hypertension, cardiovascular disease) that may affect oral health. * medications that may affect periodontal health conditions. * use of anti-inflammatory and antibiotic drugs during the last month before the examination. * smoking. * use of dietary supplements. * wearing orthodontics or prosthodontics appliances.
effect of bile acid secretion and sequestration on glp-1 secretion

Conditions: Diabetes Mellitus, Type 2

Summary: accumulating evidence suggests that bile acids in our intestines may constitute essential components in the complex mechanisms regulating gut hormone secretion and glucose homeostasis. thus, it is likely that modification of the enterohepatic circulation of bile acids can lead to changes in gut hormone secretion and consequently affect glucose homeostasis. the current study is a human interventional randomized controlled cross-over study including four study days for each participant. as a tool to sequester bile acids we will use sevelamer, a phosphate binding resin used in the treatment of hyperphosphataemia in adult patients with chronic kidney disease. surprisingly, sevelamer has been shown to improve glycaemic control in patients with chronic kidney disease and type 2 diabetes. intravenous infusion of cholecystokinin will be used to elicit gallbladder contraction and emptying. the aim is to examine how (and if) bile acid sequestration can influence postprandial glucagon-like peptide-1 (glp-1) secretion and glucose homeostasis in patients with type 2 diabetes. the investigators hypothesize that higher luminal concentrations of bile acids in the distal gut will elicit changes in gut hormone secretion. the current study will help to clarify this hypothesis and improve our general understanding of the association between bile acid circulation and signalling, gut hormone secretion and glucose metabolism.


Eligibility criteria:
inclusion criteria: * type 2 diabetes for at least 3 months (diagnosed according to the criteria of the world health organization (who)) * men and postmenopausal women * metformin applied as the only anti-diabetic drug * caucasian ethnicity * normal haemoglobin * age above 40 years and below 70 years * bmi \>23 kg/m2 and \<35 kg/m2 * informed and written consent exclusion criteria: * liver disease (alanine aminotransferase (alat) and/or serum aspartate aminotransferase (asat) \>2 times normal values) or history of hepatobiliary disorder * gastrointestinal disease, previous intestinal resection, cholecystectomy or any major intra-abdominal surgery * nephropathy (serum creatinine \>150 µm and/or albuminuria) * hypo- and hyperthyroidism * hypo- and hypercalcaemia * hypo- and hyperphosphataemia * active or recent malignant disease * treatment with medicine that cannot be paused for 12 hours * treatment with oral anticoagulants * any treatment or condition requiring acute or sub-acute medical or surgical intervention * any condition considered incompatible with participation by the investigators
functional imaging of the therapeutic effect of pregabalin in treatment for neuropathic pain

Conditions: Diabetic Neuropathies; Pain

Summary: functional imaging of the therapeutic effect of pregabalin in treatment for neuropathic pain in patients with diabetic polyneuropathy using proton magnetic resonance spectroscopy (mrs): the aim of our study is to investigate the effect of pregabalin as a treatment for neuropathic pain in a homogeneous study population, using proton mrs (1h mrs) focusing on four regions of interest (bilateral thalami, rostral anterior cingulated cortex (racc) and dominant dorsolateral prefrontal cortex (dlpc).

spectrum measurements at: thalamus left thalamus right rostral anterior cingulated cortex dominant dorsolateral prefrontal cortex measurements: gamma-aminobutyric acid (gaba) glutamate (glu) glutamine (gln) n-acetylaspartate (naa) choline-containing compounds (cho) creatine plus phophocreatine (total creatine: cr) myo-inositiol (ins) choline (cho) glucose (glc) lactate (lac)

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patients with painful dpn * patient willing to provide informed consent * type 1 or type 2 diabetes with hba1c ≤ 11% * stable antidiabetic medication for 30 days prior to randomization * duration of painful dpn ≥ 3 months * visual analogue scale (vas) score ≥ 4 exclusion criteria: * creatinine clearance ≤ 60ml/min * presence of other clinically significant or disabling chronic pain condition * active malignancy * evidence of an active disruptive psychiatric disorder or other known condition that might influence the perception of pain, compliance to intervention and/or ability to evaluate treatment outcome as determined by the investigator * life expectancy less than 1 year * existing or planned pregnancy * extreme fear for entering mri * general contraindication for mri (pacemaker, etc...) * patients participating in other clinical trials * age \<18 years * prior use of potential retinotoxins * prohibited medications without proper wash-out period (\>7days, depending on the type of medication): * medications and supplements commonly used for relief of neuropathic pain * antiepileptics * antidepressants (except for stable regiments of ssris for treatment of anxiety or depression) * nsaid

Keywords: neuropathic pain diabetic polyneuropathy
hypertension and diabetes initiative - improving hypertension control in individuals with diabetes

Conditions: Hypertension

Summary: twelve health organizations from around the us were selected to participate in a chart review hypertension and diabetes initiative with the goal of improving blood pressure control in persons with diabetes. hypothesis: a three-phase quality improvement initiative facilitated and monitored through the international diabetes center (idc) will result in improved population-mean systolic blood pressure in the aggregate data pool of patients from all 12 participating sites at geographically distinct health systems.

phase 1 - preparation: each participating site begins to organize itself for the project. baseline data will be collected and will be used to benchmark where each site is relative to blood pressure control/management of persons with diabetes prior to the implementation of the training programs. phase 2 - implementation: sites begin to address the gaps they have identified that affect blood pressure outcomes of patients with diabetes. idc provides two on-site training programs for providers and support staff. phase 3 - follow-up: idc provides on-going support to each site via individual and collaborative conference calls and resources on the project web site. patient and visit data (audit form) will be collected six and 12 months after training. this data will be compared to the site's pre-training data.

Eligibility criteria:
inclusion criteria: * icd-9 code 250 (indicates type 1 or type 2 diabetes) * icd- code 648.0 (indicates pregnancy with type 1 or type 2 diabetes) * icd-9 code 357.2 or 362.0, indicating complications of diabetes. * a prescription for insulin or oral hypoglycemic agents * include those 18-75 years exclusion criteria: * attend a dialysis unit (if the nephrologist is primary care manager) * have gestational diabetes (icd-9 code 648.8) * have a terminal illness (e.g., hospice patient) * do not have a documented blood pressure within the past year (this is asked on the audit form)

Keywords: hypertension diabetes quality improvement blood pressure
effectiveness of symbiotic therapy in jaundiced patients

Conditions: Postoperative Infections; Jaundice

Summary: the aim of the present study was therefore to evaluate if the perioperative administration of symbiotics reduces postoperative infectious morbidity in jaundiced patients scheduled for hepato-biliary and pancreatic surgery.

despite advances in preoperative patient's selection and anesthetic and surgical techniques, surgery in jaundiced patients is associated with significant morbidity and mortality as a consequence of septic complications. the evidence that nosocomial infections are frequently a consequence of gut-derived organism such as enterobacteriaceae, supports the hypothesis of the "gut derived sepsis". indeed, several studies have reported that jaundiced patients present an increased intestinal permeability and consequently a higher rate of bacterial migration from gastrointestinal tract across the lamina propria to local mesenteric lymph nodes and from there to extra-intestinal site. this phenomenon increases after surgical decompression of bile duct. the higher prevalence of bacterial translocation in jaundiced patients is related to different mechanisms such as mucosal atrophy secondary to protracted absence of intraluminal bile that open para-cellular route for bacterial translocation and the decreased clearance capacity of kuppfer secondary to cholestasis. the mechanisms of action of symbiotics are largely unknown. the probiotic bacteria can improve the mucosal barrier function reducing the bacterial translocation of organism to mesenteric lymph nodes. indeed symbiotic can affect the intestinal ecosystem by stimulating mucosal immune and non-immune mechanisms through antagonism/competition with potential pathogens.

Eligibility criteria:
inclusion criteria: * jaundiced patients scheduled for elective extrahepatic bile duct resections * age between 18 and 80 year-old exclusion criteria: exclusion criteria * cirrhosis * american society of anesthesiologists (asa) score 4 * intestinal malabsorption * emergency surgery * intolerance to symbiotic * diagnosis of primary or secondary immunodeficiency * unresectability

Keywords: sepsis jaundice symbiotic translocation abdominal collection morbidity
iron deficiency in pediatric heart surgery

Conditions: Iron Deficiencies; Iron Deficiency Anemia; Cardiac Surgical Procedures; Congenital Heart Disease in Children

Summary: the prevalence of iron deficiency in pediatric cardiac surgery patients is not very well known. iron deficiency can lead to anemia, higher transfusion rates and possibly higher complication rates. in this retrospective study, the iron status of all patients undergoing pediatric cardiac surgery at our institution between january 2019 and december 2023 will be analyzed. together with iron status, transfusion requirements as well as complications will be recorded. iron status will be reported with descriptive statistics, patients with or without iron deficiency will be compared using non-parametric tests.


Eligibility criteria:
inclusion criteria: * all patients who underwent pediatric cardiac surgery at our institution between january 1, 2019 and december 31, 2023 exclusion criteria: * incomplete medical charts * patients who did not consent to the use of their medical data
comparison of effect of prolotherapy and paraffin waxes for hand osteoarthritis

Conditions: Hand Osteoarthritis

Summary: patients with hand osteoarthritis will be randomized into two groups, paraffin wax and prolotherapy group. patients will be evaluated before and after treatment , after 2 weeks 4 weeks and 3 months after treatment. evaluation parameters are visual analog scale, duruoz hand index scales, grip strength, lateral pinch, two point pinch and three point pinch strengths.

this study is a randomized clinical trial. 40 patients with hand osteoarthritis will be randomized into 2 groups, paraffin wax and prolotherapy group.paraffin group patients will be told to take of jewellery and dip their hands into the bath of melted wax (52 ºc) with hands open and hand wrist in neutral position for 10 times .in paraffin wax group, patients will be treated 5 days a week for 2 weeks period. paraffin wax bath will be applied for 20 minutes in every physical therapy session. prolotherapy is a nonsurgical regenerative injection technique that introduces small amounts of an irritant solution to the site of painful and degenerated tendon insertions (entheses), joints, ligaments, and in adjacent joint spaces during several treatment sessions to promote growth of normal cells and tissues.hypertonic dextrose solution is most common used agent. in prolotherapy group, %15 dextrose solution will be applied to medial and lateral aspect of proximal interphalangeal joints (pij), distal interphalangeal joints and carpometacarpal joint of thumb for 3 sessions once a week period. grip strength, lateral pinch, two point pinch, three point pinch strengths, visual analog scale (vas), duruoz hand index scales will be assessed before the intervention and after two weeks, 4 weeks and 3 months after intervention .

Eligibility criteria:
inclusion criteria: * hand osteoarthritis defined according to american college of rheumatology criteria * older than 40 years exclusion criteria: * carpal tunnel syndrome * de quervain tenosynovitis * dupuytren's contracture * secondary osteoarthritis due to rheumatoid arthritis, chondrocalcinosis, psoriatic arthritis, hemachromatosis * trigger finger

Keywords: paraffin prolotherapy hand osteoarthritis
effect of dexmedetomidine on postoperative mental disorders and long-term survival in elderly patients

Conditions: Cohort Studies

Summary: china's aging population is causing an increase in the number of senior persons undergoing surgery. more and more clinicians are paying attention to the postoperative survival and mental health of elderly surgical patients. dexmedetomidine (dex) is an alpha-2 adrenergic agonist that works by inhibiting norepinephrine releasing renaline, which reduces inflammation and thus plays a protective role in the central nervous system. dex has the potential to prevent and treat postoperative anxiety and depression in elderly patients undergoing non-cardiac surgery. further exploration of evidence for evidence-based medicine is needed. based on the above research background, this hypothesis is proposed: in elderly patients undergoing noncardiac surgery, intraoperative dex is associated with a reduction in short-term postoperative mental disorders and a reduction in long-term postoperative mortality.

studies have suggested that continuous infusion of low-dose dex during the night after surgery can significantly reduce the incidence of delirium, alleviate pain, and improve subjective sleep quality. however, it is currently unclear whether choosing dex during anesthesia has any impact on mortality and mental disorders in older patients undergoing non-cardiac surgery. therefore, we utilized prospective research data from 7 centers in china to explore the relationship between intraoperative use of dex and postoperative 12-month mortality and mental disorders. propensity score-matching (psm) and inverse probability of treatment weighting (iptw) were conducted, and subgroup analyses were also applied.

Eligibility criteria:
inclusion criteria: 1. age ≥65 years old, regardless of gender 2. patients undergoing general anaesthesia (combined sedation or intravenous general anaesthesia) 3. asa level 1-3 4. patients undergoing elective non-cardiac surgery, non-neurosurgery exclusion criteria: 1. more than 20% missing data for covariates; 2. postoperative admission to the intensive care unit (icu) or death during follow-up; 3. preoperative history of severe sleep disorder and taking related medication; 4. have a history of severe anxiety or depression prior to surgery and taking relevant medication; 5. severe hearing, speech and cognitive impairments that preclude access to follow-up visits

Keywords: dexmedetomidine postoperative mental disorders long-term survival elderly patients depression anxiety delirium
h - test usage in identification of sexual orientation among people.

Conditions: Sexual Behavior; Sexual Orientation Conflict Disorder; Sexual Arousal Disorder; Sexual Orientation; Sexual; Orientation, Relationship Disorder

Summary: using of h - test in identifying the sexual behavior of the human.

the test using videos and in the same time watching the vital signs of the participant to identify any changes in them align with the vides. these videos contain +18 contents that can excite them and make them sexually active. so we can determine with type of vides that more excited to the human and select his or her sexual behavior type.

Eligibility criteria:
inclusion criteria: * all the people can be included exclusion criteria: * have a psychological disorder * have a sexual disorder
a phase i/ii clinical study of sk&f-105517-d in japanese patients with chronic heart failure

Conditions: Heart Failure, Congestive

Summary: the primary objective of this study is to evaluate the safety and tolerability of sk\&f-105517-d in japanese patients with chronic heart failure.


Eligibility criteria:
inclusion criteria: * patients with symptomatically stable chronic heart failure (chf) based on ischemic heart disease or dilated cardiomyopathy * patients who are maintained on basic heart failure therapy with angiotensin converting enzyme (ace) inhibitors or angiotensin ii receptor blocker (arb) and their dosage/administration is not changed within 2 weeks * patients diagnosed with new york heart association (nyha) class i to iii * patients with a left ventricular ejection fraction (lvef) between 25% and 45% exclusion criteria: * patients contraindicated for ß-blockers * patients with occurrence of acute myocardial infarction within 2 weeks * patients with unstable angina, coronary spastic angina, or angina at rest * patients who have collected blood \>400 ml within 4 months prior to screening or \>200 ml within 1 months

Keywords: carvedilol phosphate ß-blocker sk&f-105517-d chronic heart failure(chf)
inspiratory muscle training post-liver transplant

Conditions: Liver Disease Chronic; Muscle Weakness; Respiratory Insufficiency

Summary: individuals with chronic liver disease develop significant muscle wasting that remains post-liver transplant. the transplant surgery additionally challenges respiratory mechanics. respiratory muscle strength has been measured to be impaired in individuals post liver transplant. this study proposes an 8 week intervention designed to increase respiratory muscle strength and pulmonary function that we hypothesize will correlate to improved functional performance and quality of life post-liver transplant. pre-test post-test design, that will randomize subjects into an experimental group that will receive the inspiratory muscle strengthening exercise in addition to usual post-liver transplant care and a control group that will only receive the usual post-transplant care. up to 50 subjects will be recruited from the post-liver transplant outpatient clinic at the miami transplant institute. the subjects will have repeated measurements of respiratory muscle strength, pulmonary function, functional mobility performance, and quality of life at baseline, 4 weeks, and 8 weeks.


Eligibility criteria:
inclusion criteria: 1. subjects must have undergone liver transplantation for chronic liver disease of any origin other than cancer. exclusion criteria: 1. severe cardiopulmonary disease such as recent myocardial infarction, congestive heart failure, pulmonary edema, chronic obstructive pulmonary disease, and asthma, 2. severe osteoarthritis 3. blindness 4. wheelchair bound individuals 5. individuals with neurological / neuromuscular disorders including but not limited to: cerebral vascular accident, parkinsonism, alzheimer's disease, dystonia, multiple sclerosis, and polio. 6. severe cognitive impairment where individuals cannot follow commands and are unable to sign informed consent -

Keywords: liver disease transplant muscle wasting breathing exercise