Kornimate/medical-research-clean huggingface dataset:
prospective investigation of the effects of different treatment techniques on myofascial trigger points in patients with temporomandibular dysfunction (tmd)

Conditions: Low Level Laser and Occlusal Splint

Summary: in the literature, there are no studies comparing the use of occlusal splint and low level laser (lll) in the treatment of temporomandibular disfunction (tmd) and including ultrasonography (usg) in these parameters. in this study, it is aimed to contribute to the literature in terms of determining which treatment method is more effective by evaluating the changes in the needles muscles with the use of occlusal splints and lll with usg and other parameters in certain periods, as well as evaluating which parameters are more effective.


Eligibility criteria:
inclusion criteria: * patients over the age of 18 who apply with temporomandibular joint (tmj) problems * patients with pain in the joint and chewing muscle area exclusion criteria: * syndromic patients * patients under the age of 18 * patients with a history of orthognathic surgery * pregnants * antidepressant users * patients using removable dentures * patients who have had joint treatment in the past six months

Keywords: low level laser occlusal splint temporomandibular disfunction
efficacy of bone marrow mesenchymal stem cell in pulmonary hemosiderosis

Conditions: Idiopathic Pulmonary Hemosiderosis

Summary: pulmonary hemosiderosis (ph) is a pulmonary hemosiderin deposition which caused by alveolar capillary hemorrhage. ph is easy to recurrent and can lead to pulmonary fibrosis and insufficiency if the disease was poor controlled. steroid is the most common drug that was administered in acute phase of the disease. however, considered the side-effects, steroid is not suitable for long-time maintenance. therefore, it is necessary to explore a new therapy. bone marrow mesenchymal stem cells (bmsc) are a kind of adult stem cells with high self-renewal and multi-directional differentiation potential in bone marrow. it has become a hot topic in immunosuppressive and tissue repair therapy in recent years. to date, homing, colonization and differentiation of bmscs in the lung have been observed in animal models of pulmonary hypertension, radiation pneumonitis and pulmonary fibrosis. it had been reported that bmsc transplantation in acute lung injury in mice, inflammation of lung injury can significantly improve. the aim of this study is to explore the effect of bmsc on ph and its mechanism, and to explore a new way to promote the repair of iph. it is expected to improve the status of iph therapy in children, especially improve the prognosis of refractory ph.


Eligibility criteria:
inclusion criteria: * patients diagnosed with pulmonary hemosiderosis at an age less than 18 years. exclusion criteria: * patients who cannot finish the established causes or die during the causes.

Keywords: idiopathic pulmonary hemosiderosis bone marrow mesenchymal stem cells
efficacy and safety of adjunctive minocycline in the treatment of autoimmune encephalitis

Conditions: Autoimmune Encephalitis

Summary: autoimmune encephalitis (ae) is an immune-mediated brain disorder characterized by varied clinical manifestations that correlate with specific types of antibodies.typical symptoms include acute behavioral changes, psychosis, seizures, memory deficits, dyskinesias, speech impairments, and autonomic and respiratory dysregulation.while the majority of patients respond well to immunotherapeutic agents, a significant proportion remains resistant to initial and secondary-line immunotherapies.minocycline, a semisynthetic tetracycline, is notably used for the central nervous system due to its lipophilic characteristics and its capacity to penetrate the blood-brain barrier. while the primary neuroprotective focus of minocycline in the central nervous system remains unknown, the primary effects of minocycline include the inhibition of microglial activation, mitigation of apoptosis, and reduction in reactive oxygen species generation.protective effect has been observed in hypoxic injury, ischemic stroke, amyotrophic lateral sclerosis, traumatic spinal cord injury, multiple sclerosis, parkinson's disease, and huntington's disease.can minocycline offer a protective role in ae? consequently, we proposed a randomized, controlled trial to investigate the efficacy of minocycline in ae.


Eligibility criteria:
inclusion criteria: 1. diagnosis of definite autoimmune encephalitis(graus et al 2016.) 2. age ≥ 18 years 3. acute or subacute onset (rapid progression of less than 3 months) 4. reasonable exclusion of alternative causes 5. written informed consent exclusion criteria: 1. known allergy to tetracycline antibiotics. 2. pregnant women. 3. uncontrolled serious concomitant illness. 4. known chronic kidney disease stages 3b-5. 5. moderate liver disease (see child-pugh for classification of severity of liver disease). 6. history of cognitive impairment

Keywords: autoimmune encephalitis minocycline
effectiveness of graded motor imagery to improve hand function in patients with distal radius fracture

Conditions: Distal Radius Fracture; Pain

Summary: the purpose of this study was to investigate of the effectiveness of graded motor imagery (gmi) on hand functionality in patients with distal radius fracture (drfx). this study was carried out on 36 patients. these patients were randomly assigned to two groups: classic treatment group (n=19) and gmi group (n=17). both groups received a 8-week (2 days a week) physical therapy and rehabilitation intervention. outcome measurements were based on upper extremity functional status (disability of the arm shoulder hand and michigan hand questionnaire scores), pain (on the rest and during the activity with visual analog scale), range of motion (wrist flexion, extension, ulnar/radial deviation, supination and pronation with goniometer), grip strength (standard grip strength with jamar hydraulic hand dynamometer; lateral, palmar and pinch strength with pinch meter).


Eligibility criteria:
inclusion criteria: * ages between 18-65 years * diagnosed with drfx which is extra-articular * managed with pins, internal fixation and/or cast exclusion criteria: * unwilling or unable to participate * intra-articular and instable fractures containing other part of the fractures * fractures related with the malignancy and other neurologic diseases * existing inflammatory joint condition, * lack of cognitive function.
long-term open-label safety study to evaluate en3409

Conditions: Low Back Pain; Osteoarthritis; Neuropathic Pain

Summary: the purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of en3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended period of time.


Eligibility criteria:
inclusion criteria: * female subjects who are practicing abstinence or using a medically acceptable form of contraception or have been postmenopausal, biologically sterile, or surgically sterile for more than 1 year * male subjects who are practicing abstinence, surgically sterile, or are using a medically acceptable form of contraception * de novo subject with a clinical diagnosis of moderate to severe noncancer-related cp (eg, clbp, oa, neuropathic pain) for ≥ 3 months * de novo subject that is treating their cp with a stable daily maintenance dose of atc opioid analgesic medication equivalent to ≥ 60 mg and ≤ 160 mg morphine sulfate equivalent (mse) per day for ≥ 4 weeks * stable health, as determined by the principal investigator * subject is willing and able to comply with all protocol required visits and assessments * rollover subject who has completed the 12-week double-blind treatment phase in the en3409-307/308 clinical study exclusion criteria: * a history or current evidence of any clinically significant disorder or any other condition, which in the opinion of the investigator, would jeopardize the safety of the subject or impact the validity of the study results * females who are pregnant, breastfeeding, or plan to become pregnant during the study * current cancer-related pain or received chemotherapy within 6 months of screening * subjects receiving opioid analgesic medication \< 60 mg mse per day within 28 days of screening * de novo subjects receiving opioid analgesic medication at doses of \> 160 mg mse per day within 28 days of screening * subjects with a history of other chronic painful conditions, other than the index cp condition, which require frequent analgesic medication * reflex sympathetic dystrophy or causalgia (complex regional pain syndrome), acute spinal cord compression, cauda equina compression, acute nerve root compression, meningitis, or discitis * history of allergy or contraindications to any opioid or acetaminophen * surgical procedure for relief of pain within 6 months, or nerve/plexus block within 28 days of screening * hypokalemia or clinically unstable cardiac disease * moderate to severe hepatic impairment * moderate to severe renal impairment * current or past history of alcohol or substance * positive urine toxicology screen for drugs of abuse * history of abnormalities on physical exam, vital signs, ecg, or lab values

Keywords: chronic pain clbp chronic low back pain back pain osteoarthritis oa neuropathic pain nerve pain painful neuropathy
comparison of laparoscopic and open inguinal hernia repair in elderly patients

Conditions: Urinary Retention; Postoperative Complications; Pain; Relapse

Summary: inguinal hernia is one of the most frequently performed surgeries in general surgery. this surgery can be performed with both open and laparoscopic techniques. there is no clear consensus on whether inguinal hernia repair, which is one of the most frequently performed surgeries in elderly patients, should be performed open or laparoscopic. the application of the open technique with regional anesthesia methods such as spinal anesthesia and local anesthesia makes these methods attractive. the fact that laparoscopic techniques cause patients to recover faster also makes these techniques attractive. however, the fact that it is usually performed under general anesthesia is a significant disadvantage. increasing comorbidities and increased drug use, especially in elderly patients, make surgeons think about which technique to prefer. the aim of this study is to compare open and laparoscopic inguinal hernia repair, which should be preferred in patients over 65 years of age.


Eligibility criteria:
inclusion criteria: * patients with inguinal hernias. * patients aged over 65. exclusion criteria: * younger than 65 years. * incarcerated or strangulated inguinal hernias.
neurocognitive habilitation for children with fetal alcohol syndrome (fas)/alcohol-related neurodevelopmental disorder (arnd)

Conditions: Fetal Alcohol Syndrome; Alcohol-related Neurodevelopmental Disorder

Summary: children will receive comprehensive evaluations through the children's research triangle (crt) clinical program. the assessment for the child will be in accordance with the protocol developed by astley and clarren as performed by one of the clinic pediatricians and final diagnosis will be according to institute of medicine (iom) criteria. children will be randomized into either a treatment or control group. the treatment group will receive (in addition to standard referrals) neurocognitive habilitation and psychotherapy services as well as parent psychoeducation. the control group will be referred for intervention through existing community and school-based agencies.

neurocognitive habilitation, based on the traumatic brain injury literature for teaching compensatory skills, will be the primary intervention. interventions will be individually designed and delivered through individual therapy sessions. audiotapes will augment the sessions to facilitate implementation of strategies in the home environment. didactic therapy will be used to foster appropriate interactions and relationships between parent and child. children will participate in 8-week group sessions that will include neurocognitive exercises, homework sessions, and possibly group psychotherapy. an educational specialist will provide school and legal advocacy services as well as observations of the child in the classroom that could lead to educational modifications. parent component: family education programs and parent support groups using psychoeducational approaches will be the means of intervening with parent behaviors. parents will be instructed on becoming advocates for their child. groups of 8 to 12 parents will meet for one 2-hour session per week for 8 weeks. each session will include: 1. neurocognitive exercises (relaxation); 2. specific topic discussions; and 3. general support. during the last hour of the final two weeks of the program, parent and children will be combined to practice learned techniques. children and parents will participate in monthly "booster" sessions. evaluation plan: treatment and control groups will be compared using pre- and post-test measures. post-tests will be at the conclusion of the intervention, as well as at 12, and 24-month follow-ups. process and outcome measures will be evaluated.

Eligibility criteria:
inclusion criteria: * children aged 6 to 12 years * children in the care of illinois foster care

Keywords: fetal alcohol syndrome (fas) alcohol-related neurodevelopmental disorder (arnd)
the risk factors of symptomatic gallbladder stone: age-sex matched case-control study performed in single institute

Conditions: Gallstone

Summary: the main purpose of this study is to investigate the region-specific cause of gallbladder stone incidence in jeju self-governing province, korea.

investigators performed the epidemiologic study to uncover the reason of relatively higher incidence of gallbladder cancer in small isolated island, jeju island, one of small province among 11 self governing area in south korea. tow studies, including descriptive epidemiology and analytic epidemiology using case-control study, some risk factors were obtained regarding gallbladder cancer development in this area. old age, female, and gallstone were potential risk factors and alcohol consumption was preventive factors. so authors decided to evaluate the relationship between alcohol and gallbladder stone in order to how much portion of causal relationship they have with gallbladder cancer. so this study was designed to investigate the relationship between gallbladder stone and alcohol consumption then performed clinical based case-control study with age-sex matching to each subjects.

Eligibility criteria:
case group inclusion criteria: * clinical diagnosis of gallstone disease after cholecystectomy. exclusion criteria: * ambiguous diagnosis cases for gallbladder stone. * incomplete medical record. control group inclusion criteria * healthy examinees in health promotion center in same institute * eligible cases of abdominal ultrasound(us) or computed tomography(ct) exclusion criteria * the case who was diagnosed as asymptomatic gallstone on abdominal us

Keywords: gallbladder stone risk factor case-control study obesity hypertension alcohol consumption
high versus low frequency rtms on motor dysfunction in pd

Conditions: Parkinson Disease

Summary: the aim of the study is to compare high versus low frequency rtms on motor dysfunction in pd. forty patients with pd participated in the study. the patients were randomly assigned into two groups; the first group received 1hz and the 2nd one received 20 hz rtms daily for 10 days 5 sessions every week. the doctors who assess the patients clinically is blind for the frequency of rtms, also patients don't know which type of stimulation they received. the patients were followed up before and after the 10 sessions and one month later.

the aim of the study is to compare high versus low frequency rtms on motor dysfunction in pd. forty patients with pd participated in the study. the patients were randomly assigned into two groups; the first group received 1hz and the 2nd one received 20 hz rtms daily for 10 days 5 sessions every week and 2 days off per week. the doctors who assess the patients clinically is blind for the frequency of rtms, also patients don't know which type of stimulation they received. the patients were followed up before and after the 10 sessions and one month later.

Eligibility criteria:
inclusion criteria: * all pd patients who were diagnosed according to uk bank criteria for pd. exclusion criteria: * history of repeated head injury. * history of repeated cerebrovascular strokes * history of defined encephalitis * oculogyric crisis, supra nuclear gaze palsy. * family history of more than one relative * severe dementia, mmse \< 23, severe depression * cerebellar signs * babiniski sign * hydrocephalus or intracranial lesion on neuroimaging * patients with intracranial on neuroimaging * patients with intracranial metallic device or pacemaker * patients who were unable to give informed consent because of severe anesthesia, or cognitive deficit
radiofrequency-assisted transection of the pancreas vs stapler

Conditions: Pancreas; Fistula

Summary: main objective: the main end-point of this study is to compare in a randomized clinical trial that radiofrequency-assisted pancreas transection (rf) reduces the incidence of postoperative pancreatic fistula (popf) compared to the classical method of transection (stapler). as secondary end-points, other clinical and demographic variables of the patients will be evaluated (sex, age, asa classification, consistency of the pancreas, as well as the type of procedure, open or laparoscopic surgery, estimated intraoperative bleeding, pancreatic duct size, duration of intervention, type of tumor and quality of lymphatic resection). methodology: phase iii prospective multicenter study in patients undergoing distal pancreatectomy for any origin. all consecutive patients who undergo a distal pancreatectomy for any cause in a multicenter setting will be included. a simple randomization of the participants to the rfa group or to the control group (stapler) will be carried out. the incidence of pancreatic fistula will be assessed as main variable; predictive multivariable models with multiple regression for quantitative variables, logistic regression for categorical variables and cox regression for survival analyzes. in addition to histological study, molecular analysis of resection specimen and clinical and radiological follow-up with volumetry of necrosis in the area of post-pancreatectomy transection will be performed.


Eligibility criteria:
inclusion criteria: * solid or cystic, benign or malign pancreas neoplasms. * patients undergoing a distal pancreatectomy, i.e pancreas transection beyond \> 2 cm from the smv (assessed by computer tomography or rm) with or without splenectomy * both open and laparoscopic approaches are valid. exclusion criteria: * patients who required a pancreatectomy with transection at the level of the neck. * non-intervention group: only stapler transection will be accepted, other pancreatic transection methods will be excluded. * patients asa≥iv * absence of informed consent * underage (\<18 years)

Keywords: pancreas fistula distal pancreatectomy radiofrequency
the investigation of public awareness of core stroke symptoms

Conditions: Stroke; Awareness; Health Knowledge, Attitudes, Practice; Core Symptoms; FAST

Summary: to investigate public awareness of core stroke symptoms in more than 40 years old population and its related factors.


Eligibility criteria:
inclusion criteria: * more than 40 years old (born before december 31st 1976) without specific requirements. * be able to finish the questionnaire. exclusion criteria: * participants with disturbance of consciousness.

Keywords: stroke core symptoms public awareness fast
the impact of a customized informative video prior to induction of labor on anxiety relieve.

Conditions: Induction of Labor Affected Fetus / Newborn

Summary: to determine whether watching a personalized video prior to medically indicated labor induction among term parturients reduces anxiety levels according to the stai questionnaire, compared to a standard counselling.

the prevalence of induction of labor (iol) has increased over the last decade, reaching between 15 to 30% of all deliveries in developed countries. iol is commonly carried out using an extra-amniotic balloon (mechanical induction) or prostaglandins (pharmacological induction). medical indications for iol include maternal and fetal indications, where inducing labor results in improved maternal and neonatal outcomes compared with conservative management. the process of labor induction can be associated with anxiety, especially in women undergoing iol for the first time. previous studies have focused on iol success, examining the vaginal delivery rate or the time to delivery. only a few studies have addressed the discomfort and anxiety that might accompany the procedures of iol. a previous study from australia found that women undergoing iol wished to be presented with choice options, and receive more information about the process and its possible risks. a swedish study found that the birth experience of women who underwent labor induction was less positive than that of women who gave birth spontaneously, with the former expressing greater concern for the baby's health. personalized video technology allows for the creation of a customized instructional videos, that may help reduce anxiety and decrease the element of uncertainty regarding iol process and the expected fetal health. a possible advantage of this technology is that it may better engage patients and explain the medial intervention in a simple and clear manner. many studies have examined the effect of presenting video clips, whether standardized or personalized, before medical procedures. these studies have shown significant effectiveness in improving adherence and strengthening the individual's commitment to the procedure, as well as creating a deeper understanding of the future events when using this technology. this technology is a simple method that does not involve pharmacological or invasive medical interventions to alleviate pain and anxiety. the aim of this study is to examine whether using a personalized video reduces patients level of anxiety during induction of labor.

Eligibility criteria:
inclusion criteria: * pregnant women, aged 18-45, undergoing medical iol at term. * unfavorable cervix (bishop score \<6). * cervical ripening with either prostaglandin e2 (pge2) tablets or extra-amniotic balloon (eab). * provided consent to participate in the study. * no language barrier preventing completion of the questionnaire. exclusion criteria: * sensitivity to pge2. * preterm labor. * premature rupture of membranes. * stillbirth. * elective pregnancy termination.