Kornimate/medical-research-clean huggingface dataset:
the study of apelin-apj system on pulmonary hypertension patients and healthy subjects

Conditions: Idiopathic Pulmonary Arterial Hypertension

Summary: the purpose of this study is to * determine blood peptide levels and investigate any tissue gradients of apelin in patients with idiopathic pulmonary arterial hypertension and healthy volunteers. * evaluate the effect of exogenous apelin infusion on exercise performance in healthy volunteers and patients with idiopathic pulmonary arterial hypertension.

idiopathic pulmonary arterial hypertension remains an enigma for physician in both diagnosis and treatment. existing biomarkers, tissue characteristics and definite treatment are restricted. there are many evidences suggested that apelin-apj system associated with idiopathic pulmonary arterial hypertension (ipah). a comprehensive characterise circulating peptide levels and investigate any tissue gradients of apelin in patients with idiopathic pulmonary arterial hypertension and healthy volunteers might provide important information about pathophysiologic process and diagnostic marker. in addition, first time human study to assessment the effect of exogenous apelin infusion on exercise performance in healthy volunteers and patients with idiopathic pulmonary arterial hypertension is essential to confirm whether the relevance between animal models and clinical subjects.

Eligibility criteria:
inclusion criteria for control group: * structurally normal heart by 2d echocardiography * pulmonary artery pressure \< 25mmhg * tricuspid velocity \< 2.5ms-1 inclusion criteria for treatment group: * clinical diagnosis of pulmonary arterial hypertension that is idiopathic, associated with anorexigens associated with connective tissue disease or familial * able to give informed consent * mean pulmonary artery pressure \> 25mmhg, pulmonary capillary wedge pressure \< 15mmhg, with normal or reduced cardiac output. exclusion criteria for all group: * bleeding diathesis (pt \> 14 sec to aptt \> 40 sec) * pregnancy, or women of child bearing potential not on adequate contraception * renal or hepatic failure * severe valvular heart disease * left ventricular dysfunction (lvef \< 40) * chronic lung disease * malignant arrhythmias * chronic thromboembolic disease

Keywords: idiopathic pulmonary arterial hypertension ipah apelin apj receptor
evaluating the impact of omega-3 fatty acid supplementation (soloways™) on lipid profiles in adults with pparg polymorphisms

Conditions: LDL Hyperlipoproteinemia; Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia; Triglyceride Storage Type I or II Disease

Summary: in this study, 102 patients will be evenly randomized into two groups: one set to receive omega-3 fatty acids and the other a placebo. the process will be blinded, ensuring that neither the researchers nor the participants will know which group they are in. each participant will take two capsules daily for a duration of 90 days, with the active group receiving capsules containing 1000 mg of fish oil each. all participants will be instructed to maintain their usual diet, lifestyle, and medication regimen. at the beginning and end of the study, various health assessments, including lipid panels and c-reactive protein measurements, will be conducted. additionally, dna samples will be collected for genotyping to identify patients with specific pparg gene polymorphisms, leading to the creation of four distinct subgroups: those receiving omega-3 with and without polymorphisms, and those receiving placebo with and without polymorphisms.


Eligibility criteria:
inclusion criteria: * age between 40 and 75; * ( ldl-c level between 70 and 190 mg/dl, confirmed in at least two sequential checks conducted within the last six months prior to signing the consent form. exclusion criteria: * personal history of cardiovascular disease or hight risk (≥ 20%); * triglycerides (tg) ≥ 400 mg/dl; * obesity (body mass index \> 32 kg/m2); * assumption of lipid-lowering drugs or supplements affecting lipid metabolism within the last three months; * diabetes mellitus; * known severe or uncontrolled thyroid, liver, renal, or muscle diseases.

Keywords: pparg polymorphisms omega-3 fatty acids ldl-c triglycerides cardiovascular health personalized medicine
a 2 week study of topical kd7040 in the treatment of postherpetic neuralgia (phn)

Conditions: Postherpetic Neuralgia; Shingles; Herpes Zoster; Neuropathic Pain

Summary: this study will evaluate the safety and efficacy of 2 weeks of topical kd7040 versus placebo in the treatment of postherpetic neuralgia.


Eligibility criteria:
inclusion criteria: * male or female subjects ages 18-85 years * previous diagnosis of shingles (herpes zoster) with pain persisting for at least 3 months, but not longer than 5 years, after healing of rash * subject with intact skin in the targeted treatment area * female subjects of childbearing potential must have a negative serum pregnancy test at screening, a negative urine human chorionic gonadotropin (hcg) test prior to randomization, and must use medically acceptable methods of birth control. all subjects must agree to take every precaution to ensure that pregnancy will not occur during the study. * subject must be willing and able to complete screening and study procedures as described int he protocol. * subject must voluntarily provide written informed consent prior to participation. exclusion criteria: * subjects with known hypersensitivity to kd7040 or methylparaben, or previous exposure to kd7040. * subjects pregnant, nursing or planning to become pregnant. * subjects who are immunocompromised or have clinically significant hematological abnormalities. * subjects with system dermatological conditions (e.g., psoriasis, atopic dermatitis) or impaired wound healing. * subjects who have had local anesthetic nerve blocks within 48 hours of study entry. * subjects having other sever pain which may confound assessment of phn. * subjects who have serious, unstable, or clinically significant medical or psychological conditions, which, in the opinion of the investigator(s) would compromise the subjects' participation in the study.
care navigator support for younger latinx adults with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the study proposes to rigorously evaluate a proactive, culturally responsive care navigator intervention targeting younger-onset latinx individuals with a new t2d diagnosis (aurora \[active outreach to younger latinx\]) within kaiser permanente northern california (kpnc).

the study has three primary objectives: 1) learn what is required to create and sustain a care navigator workforce and document our experience hiring a care navigator for the study, 2) implement and evaluate the aurora strategy within kpnc, and 3) refine and adapt the aurora strategy for future kaiser permanente (kp) wide dissemination. the aurora strategy centers on a care navigator who will proactively conduct three telemedicine visits tailored to latinx adults with early onset type 2 diabetes (t2d, defined as age \<45 years). the aurora strategy will conducted with the following five goals: 1) assessment of familiarity and use of t2d care within kp, 2) assessment of individual's self-management support needs, 3) motivational interviewing to support behavior change, 4) pragmatic skills training, including use of crucial technologies to support self-management, and 5) matching member's needs with existing kpnc t2d resources.

Eligibility criteria:
inclusion criteria: * kpnc member, age \>20 and age \<45 with * new clinical diagnosis of t2d within the prior 1-8 months * hba1c≥8%. if the study team are having trouble recruiting an adequate sample, the study team may lower the hba1c threshold to ≥7.5% * proficient (written and spoken) in english or spanish exclusion criteria: * pregnant women * type 1 diabetes

Keywords: care navigator, latinx
french survey about student's sleep perturbations before simulation session.

Conditions: Sleep; Anxiety

Summary: high fidelity simulation provide educational skills but the simulation of critical events could eventually provide anxiety among participants. the anxiety could raise before the simulation session and affect the perceived quality of sleep the night prior to the simulation session. the lack of sleep would eventually affect both participation and memorization during the simulation session. the investigators would like to investigate with a survey how much participants had their sleep affected before the simulation session.

high fidelity simulation provide educational skills but the simulation of critical events could eventually provide anxiety among participants. the anxiety could raise before the simulation session and affect the perceived quality of sleep the night prior to the simulation session. the lack of sleep would eventually affect both participation and memorization during the simulation session. the investigators would like to investigate with a survey how much participants had their quantity and quality of sleep affected before the simulation session.

Eligibility criteria:
inclusion criteria: * french talking residents coming to high fidelity simulation exclusion criteria: * refusal to participate

Keywords: education, medical
sclerotherapy of internal spermatic veins in patients with varicocele and localized prostate cancer

Conditions: Prostate Cancer

Summary: patients with varicocele in whon early prostate cancer will be found will undergo venographic embolization of both spermatic veins. the study hypothesis is that this procedure will induce a gradual regression of the prostate volume that may decrease prostate cancer cells. close follow-up will ensure that necessary therapy will be provided if needed according to clinical criteria. results in terms of prostate size psa level and tumor size will be recorded.


Eligibility criteria:
inclusion criteria: * males age 45-75 * prostate cancer * presence of varicocele * no contraindication for venography exclusion criteria: * diseases or medications which prevent interventional vascular procedures

Keywords: prostate cancer venography male patients localized microscopic prostate cancer up to gleason 6 (3+3) psa level <14 presence of varicocele
a study of the safety and effectiveness of doripenem in filipino patients with nosocomial pneumonia, complicated intra-abdominal infections and complicated urinary tract infections

Conditions: Pneumonia, Bacterial; Nosocomial Infection; Intraabdominal Infections; Urinary Tract Infection

Summary: the purpose of this study is to assess the safety and effectiveness of doripenem treatment among filipino patients with nosocomial pneumonia, complicated intra-abdominal infections, and complicated urinary tract infection.

this is an open-label study (all people know the identity of the treatment assigned), multi-center (conducted at multiple sites), and observational (study in which the investigators/physicians observe the patients and measure their outcomes) study to evaluate the safety and effectiveness of doripenem for the treatment of nosocomial pneumonia, complicated intra-abdominal infections and complicated urinary tract infection among filipino patients. safety evaluations for adverse events, clinical laboratory tests, physical examination, and concomitant medications will be monitored throughout the study. the total duration of study for each patient will be approximately for 3 years.

Eligibility criteria:
inclusion criteria: * patients who are diagnosed with nosocomial pneumonia including ventilator-associated pneumonia, complicated intra-abdominal infections or complicated urinary tract infection * patients who are eligible for doripenem treatment exclusion criteria: * pregnant or lactating females * patients with hypersensitivity to doripenem and/or its derivatives * known at study entry to have an infection caused by pathogen(s) resistant to doripenem * patients taking probenecid * history of severe allergies to certain antibiotics such as penicillins, cephalosporins, and carbapenems * severe impairment of renal function including a calculated creatinine clearance of less than 10 ml per minute, requirement for peritoneal dialysis, hemodialysis or hemofiltration, or oliguria (less than 20 ml urine output per hour over 24 hours)

Keywords: pneumonia, bacterial nosocomial infection intraabdominal infections urinary tract infection ventilator-associated pneumonia doripenem doribax filipino
hospital-based management of patients with chronic hepatitis b virus infection

Conditions: Chronic Hepatitis B

Summary: starting in 2022, the third affiliated hospital of sun yat-sen university implemented the "hot wave project," an integrated hbv infection prevention and control system encompassing patient education, screening, referral, treatment, and follow-up. this system is now being expanded to the sixth affiliated hospital and fifth affiliated hospital of sun yat-sen university. additionally, a multicenter, in-hospital cohort study on hbv management has been initiated.the primary aim of this study is to increase the referral rate from to 50% for hbsag-positive patients from non-hepatology/non-infectious disease departments. the secondary objective is to improve the treatment rates of hbv-infected individuals in non-hepatology/non-infectious disease departments, especially the population diagnosed but untreated (dbu). additionally, the study seeks to analyze the cost-effectiveness and clinical benefits of the in-hospital hbv screening and management strategy.

the "hot wave project" aims to establish a multicenter management cohort for hbsag-positive patients within hospitals. led by infectious disease specialists, the program conducts regular hepatitis b training sessions for hospital staff to enhance their understanding of hbv prevention and control. this initiative seeks to increase hbsag screening rates overall and encourage patients from non-infectious disease departments to seek referrals to specialized care. for all paper reports containing hbsag test results, a remark is added stating: "hbsag (+) - recommended to visit the hepatitis b health clinic in the infectious disease department." positive hbsag results are automatically extracted by the information system and sent to a dedicated computer in the hepatitis b health clinic, enabling centralized digital patient management. additionally, the infectious disease department appoints a "hepatitis b specialist assistant" responsible for reviewing hbsag screening results, notifying hbsag-positive patients or their attending physicians, and establishing follow-up records for all patients. a "hepatitis b health clinic" is also set up within the department, managed by a specialized medical team that handles the diagnosis, treatment, and education for referred chronic hepatitis b patients.

Eligibility criteria:
inclusion criteria: * hbsag-positive patients attending non-infectious disease/hepatology departments at three study centers between january 2025 and december 2025. exclusion criteria: * hbsag-positive patients already under regular follow-up in infectious disease/hepatology clinics. * chronic hbv patients on regular antiviral treatment.

Keywords: chronic hepatitis b linkage to care management
feasibility study of speedi

Conditions: Premature

Summary: the proposed feasibility study will evaluate the investigators ability to conduct a clinical trial of a novel intervention (speedi) which addresses a striking gap in the literature. supporting play, exploration, and early development intervention (speedi) differs from current early intervention practices in 2 important ways. first it bridges the traditional gap in services from the neonatal intensive care unit (nicu) to home providing ongoing and intensive support for developmental activities when parents are establishing care giving routines. second, in contrast to wide-ranging intervention provided by current early intervention models, speedi uses an action perception model to target specific behaviors which lead to improved early motor abilities and provide a foundation for learning.\[6\] the purpose of this feasibility study is to extend the investigators preliminary data and evaluate the feasibility of conducting a randomized control trial to evaluate the efficacy of speedi.


Eligibility criteria:
inclusion criteria: * infants born preterm at 34 weeks post menstrual age (pma) or less * medically stable, * off ventilator support, * demonstrate thermoregulation in an open crib by 35 weeks of pma, * live within 60 minutes of the hospital, and * have one parent who is english speaking and willing to participate in the study intervention and assessments exclusion criteria: * genetic syndrome or * musculoskeletal deformity

Keywords: premature development motor cognitive parent
whole-neck computed tomography perfusion scan in imaging patients with head and neck tumors

Conditions: Head and Neck Neoplasm; Malignant Head and Neck Neoplasm

Summary: this pilot clinical trial studies how well whole-neck computed tomography perfusion scans work in imaging patients with head and neck tumors. diagnostic imaging procedures, such as whole-neck computed tomography perfusions scans, may provide more information about the blood supply to head and neck tumors which may help doctors plan better treatment.

primary objectives: i. to assess the difference in whole-neck computed tomography perfusion (wnctp) parameters (blood volume \[bv\], blood flow \[bf\], capillary permeability \[cp\] and mean transit time \[mtt\]) between head and neck tumor masses (benign or malignant) and adjacent normal skeletal muscle within the same patient. ii. to assess whether the difference in wnctp parameters between tumor masses and adjacent normal skeletal muscle is different between patients with benign tumor versus (vs.) malignant tumor. iii. to assess the correlation in wnctp parameters between tumor masses and adjacent normal skeletal muscle. iv. determine if more suspicious cervical lymph nodes will be seen using the whole-neck coverage employed in wnctp compared to the limited coverage of traditional neck ctp. outline: patients undergo wnctp scan over 2-3 minutes during standard of care computed tomography (ct). after completion of study, patients are followed up within 2 days.

Eligibility criteria:
inclusion criteria: * confirmed or suspected head and neck tumor (benign or malignant) * scheduled for contrast ct (standard of care) * no known allergies to contrast material exclusion criteria: * known allergies to contrast material * pregnant or nursing
registry of mius for urolithiasis (remius-u)

Conditions: Urolithiasis; Stone, Kidney; Stone Ureter; Complication of Surgical Procedure

Summary: the purpose of this registry is to collect data on patients who have undergone minimally invasive treatments for urinary system stone disease, including percutaneous nephrolithotomy (pcnl), shock wave lithotripsy (swl), semi-rigid ureterorenoscopy (urs), and flexible ureterorenoscopy (f-urs).

in this project, the minimally invasive urology association urolithiasis study group aimed to collect the data of adult and pediatric urinary system stone patients treated with pcnl, swl, urs, and f-urs in a non-randomized, observational, and prospective manner. the registry was to be conducted multi-center in turkey. in this project, excel files were created and shared via google drive with the responsible physicians at the centers to be included in the study. each parameter was prepared in an explanatory manner and can be readily filled out by physicians familiar with these methods. the ability to examine and modify existing data will be restricted to the worker and the database administrator. patients' identities will not be revealed in the registry. the collected data are summarized in three sections under the major headings below; 1. demographics and preoperative information; patient, disease, and treatment method demographic data, such as age, gender, height, weight, previous diseases, medications used, location, size, and hardness of urinary tract stones, the side of the stone, and the methods used for diagnosis, will be prospectively recorded for patients whose consent was obtained. 2. data during the operation; the duration of the operation as well as the devices and methods utilized will be recorded. 3. in the postoperative period, post-treatment findings, such as stone-free status and post-treatment complications, will be documented. a separate application to the ethics committee will be submitted for each study on the subject that will be created in the future from the multi-center, prospectively recorded data pool and on the subject that will be investigated.

Eligibility criteria:
inclusion criteria: * to have a medical indication for urolithiasis * complete data of treatment and follow-up course * patients with consent * patients \> 18 years-old * patients \< 18 years-old exclusion criteria: * missing data * patients without consent * not to have a medical indication for urolithiasis treatment * to have a contraindication for urolithiasis treatment

Keywords: prospective studies registries urolithiasis
effect of iron deficiency anemia on hba1c in patients with diabetic foot ulcer grade (1and2)

Conditions: Iron Deficiency Anemia; HBA1C

Summary: diabetic foot ulcer is the commonest cause of severe limb ischemia in diabetes mellitus and development of anemia is an additional burden to the microvascular complications of diabetes

hba1c is the predominant hemoglobin found in hba1 fraction and it constitutes 5% of total hemoglobin in normal adults and up to 15%in patients with diabetes mellitus hba1c is used to diagnose diabetes and to identify individuals that are at high risk for developing diabetes iron deficiency anemia is one of the most prevalent form of malnutrition affect 1,62 billion people whish correspond to 24,8%of the world population ferritin is the storage form of iron so it is found to be test for distinguishing those with iron deficiency anemia from those who are not iron deficient

Eligibility criteria:
inclusion criteria: * all diabetic patients with diabetic foot ulcer grade one and two above 18 year exclusion criteria: 1. patients with anemia other than iron deficiency anemia 2. patients on anticoagulants 3. patients with blood disease 4-patients below 18