Kornimate/medical-research-clean huggingface dataset:
assessment of early vascular damage with advanced neuroimaging in patient with patent foramen ovale

Conditions: Patent Foramen Ovale

Summary: patent foramen ovale arises from the incomplete postnatal fusion of the septum primum and secundum and can cause paradoxical embolism in adults. in case of cerebral ischemic stroke, the correlation with the patent foramen ovale is based on probabilistic approach. for this reason, continuous research is indispensable, especially according to new approaches, to offer tools capable of guiding in case of adverse event with greater certainty and even better to prevent it. thus, this study aims to: 1) evaluate the microstructural brain damage through advanced mri analysis in patients with patent foramen ovale; 2) evaluate how much the degree of the shunt can affect brain damage. in order to do this, this study aims to evaluate advanced brain imaging in a cohort of patients with patent foramen ovale to identify the development of early vascular damage.


Eligibility criteria:
inclusion criteria: * age ≥ 18 and ≤ 65 years * patients with patent foramen ovale * written informed consent exclusion criteria: * previous ima, stroke or tia * arrhythmia or severe cardiac disease * hypertension, diabetes or renal disease * psychiatric disease * neurological or neurodegenerative disease * dementia * assumption of drugs known to interfere with cognitive function * inability to be subjected mri analysis * participation to other clinical trial, ongoing or terminated less than one month before enrolment in this study.

Keywords: magnetic resonance imaging vascular cognitive impairment
study of effectiveness of mental health interventions among torture survivors in southern iraq

Conditions: Depression; Anxiety; Post-Traumatic Stress Disorder

Summary: 1. that the psychotherapeutic intervention - components-base interventions (cbi) - is effective in reducing the severity of mental health symptoms experienced by torture survivors in southern iraq. 2. that the psychotherapeutic intervention - cognitive processing therapy (cpt) - is effective in reducing the severity of mental health symptoms experienced by torture survivors in southern iraq.

for each intervention, participants will undergo 12 sessions (cbi or cpt) that are standardized by training and manual for community mental health workers (chmws). cmhws will be trained in only one intervention. prior to the starting sessions, a baseline assessment of depression, anxiety and trauma symptoms and function will be carried out. a follow up assessment will be carried out after the 12 sessions have been completed. expected time between sessions is one week. the total time per client is expected to last about 4-5 months to complete the 12 therapy sessions. participants will be randomized (within cmhw) to either immediate intervention or wait-list control. participants that are wait-list control will be contacted monthly for assessment of condition. any participant (intervention or control) with suicidal thoughts or distress that does not abate will be referred for psychiatric care.

Eligibility criteria:
inclusion criteria: * exposure to torture * ptsd exclusion criteria: * children * mentally incompetent to understand therapy

Keywords: ptsd
the impact of the covid-19 outbreak on emergency room attendances of surgical patients

Conditions: Emergency Service, Hospital; General Surgery

Summary: since december 2019, when the novel coronavirus disease (covid-19) spread throughout the world, data have been needed on the effects of the pandemic on various aspects of healthcare systems. recommendations for social distancing and quarantine decrees made by local governments, alongside the general public fear from the spread of the virus, are presumed to have markedly affected the trends in hospitals visits. understanding the exact nature of the effect is critical for better anticipating and preparing health systems in the event of future outbreaks and in the post outbreak period. therefore we intend to to identify retrospectively all patients who presented to the emergency department at our medical institute between january 1 - march 31 in the following years: 2017, 2018, 2019, 2020. we will examine the impact of covid-19 on the rates of surgical emergency visits, ratio of surgical visits to non-surgical visits, the ratio of severe presentations to non-severe presentations, and the impact of age on ed attendance.

since december 2019, when the novel coronavirus disease (covid-19) spread throughout the world, data have been needed on the effects of the pandemic on various aspects of healthcare systems. recommendations for social distancing and quarantine decrees made by local governments, alongside the general public fear from the spread of the virus, are presumed to have markedly affected the trends in hospitals visits. understanding the exact nature of the effect is critical for better anticipating and preparing health systems in the event of future outbreaks and in the post outbreak period. additionally, deferring hospitals visits can potentially put patients at increased risk for morbidity and mortality, especially in postsurgical patients. evaluating the impact of the pandemic on patient volume can guide decision-making in future scenarios. previous infectious disease outbreaks have been shown to impact ed volumes: the us hantavirus outbreak in 1993 led to a 2-fold increase in ed visits; escherichia coli 0157:h7 outbreak in washington state in 1993 increased ed visits by 17%; however, the 2003 sars outbreaks in hong kong, taiwan, and toronto reduced tertiary care ed visits by up to 47 percent.

Eligibility criteria:
inclusion criteria: * all patients visiting the er of sheba medical center between january 1 - march 31 in the following years: 2017, 2018, 2019, 2020 exclusion criteria: * patients less than 18 years of age

Keywords: emergency surgery covid-19
a clinical trail of integrative medicine approaches for post-stroke cognitive impairment

Conditions: Post-stroke Cognitive Impairment

Summary: the traditional chinese medicine rehabilitation for the post-stroke cognitive impairment will be intervened, which can promote the recovery of post-stroke cognitive function patients, reduce the disability rate and improve the quality of life.

this study will collect inpatients from april 2019 to december 2024 who from the third affiliated hospital of zhejiang university of traditional chinese medicine, jiaxing hospital of traditional chinese medicine, hangzhou hospital of traditional chinese medicine.this study sets strict time window (stroke recovery, 30-180 days), use multi-center, large sample, randomized controlled study method and the objective recognition rehabilitation evaluation criteria and efficacy evaluation system to evaluate the clinical effect and analysis of health economics.

Eligibility criteria:
inclusion criteria: 1. stroke as per the tcm definition, presenting symptoms include unilateral paresis or paralysis, sensory deficits, speech impairment, and hemianopsia. psci diagnosis involves clinically significant deficits in at least one cognitive domain and severe disruption of instrumental activity of daily livings. 2. age above 18 years; 3. disease duration of 30-180 days; 4. written informed consent by the patient's legal guardian; 5. moca (montreal cognitive assessment) score of 17-26. if patient was educated for ≤ 12 years, one score will be deducted; 6. hamd(hamilton depression scale) score \< 20; 7. indications for acupuncture and moxibustion techniques. exclusion criteria: 1. cognitive impairment caused by subarachnoid hemorrhage, transient ischemic attack, or other intracranial lesions., such as tumors, aneurysms, vascular malformations, cysticercosis, schistosomiasis, encephalitis, meningitis, hydrocephalus, or head trauma; 2. non-atherosclerotic thrombotic cerebral infarction (such as cardiac embolism, procoagulant state, endovascular shedding, or arteritis); 3. pregnant or lactating women; 4. severe chronic diseases of the heart, liver, kidneys, other viscera, or endocrine system or hematopoietic system; 5. severe dementia, serious language understanding disorders, or mental illness; 6. bleeding tendency; 7. lack of inclusion criteria or not suitable for clinical observation.

Keywords: post-stroke cognitive impairment rehabilitation traditional chinese medicine
radioimmunoimaging of al amyloidosis

Conditions: Primary Amyloidosis

Summary: the purpose of the study is to determine the capability of a radiolabeled amyloid-reactive monoclonal antibody to document the presence and distribution of amyloid deposits by pet/ct imaging in patients with al amyloidosis.

to be eligible for this study, patients must have a confirmed diagnosis of al amyloidosis without significant cardiac (new york heart association class iv) disease and not be on kidney dialysis. additionally, after testing, their blood must not contain antibodies to mouse proteins. the study requires an intravenous infusion, given over 10 minutes, of the radiolabeled antibody, followed 48 hours later by a pet/ct scan. a repeat scan is done 5 to 7 days after infusion of the antibody. a 5 ml blood specimen needs to be furnished 4 and 8 weeks after the antibody infusion.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of al amyloidosis exclusion criteria: * new york heart association class iv * patient on renal dialysis * serum antibodies to mouse protein

Keywords: radioimmunoimaging al amyloidosis pet/ct
combination chemotherapy in treating patients with recurrent or refractory small cell lung cancer

Conditions: Lung Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining more than one drug may kill more tumor cells. purpose: phase ii trial to study the effectiveness of combination chemotherapy in treating patients who have recurrent or refractory small cell lung cancer.

objectives: i. determine the overall, complete, and partial response rates of patients with recurrent or refractory small cell lung cancer when treated with gemcitabine plus irinotecan. ii. determine the overall and failure free survival of these patients when treated with this regimen. iii. determine the duration of response of these patients after this treatment. iv. evaluate the toxicity associated with the administration of this treatment in this patient population. outline: patients are stratified according to prior response duration (progression 90 days or more after initial therapy vs progression less than 90 days after initial therapy or no response to initial therapy). patients receive gemcitabine iv over 30 minutes and irinotecan iv over 90 minutes on days 1 and 8. treatment continues every 21 days in the absence of disease progression or unacceptable toxicity. patients are followed every 3 months for 1 year, then every 6 months for 2 years, and then annually for 3 years. projected accrual: a total of 78 patients will be accrued for this study over 12-18 months.

Eligibility criteria:
disease characteristics: histologically or cytologically confirmed recurrent or refractory small cell lung cancer measurable disease at least 20 mm with conventional techniques or at least 10 mm with spiral ct scan the following are not considered measurable: bone lesions leptomeningeal disease ascites pleural/pericardial effusion abdominal masses not confirmed and followed by imaging techniques cystic lesions tumor lesions situated in a previously irradiated area known cns metastases allowed patient characteristics: age: 18 and over performance status: ctc 0-2 life expectancy: not specified hematopoietic: granulocyte count at least 1,500/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than 1.5 mg/dl renal: creatinine no greater than 2.0 mg/dl other: not pregnant or nursing fertile patients must use effective contraception no prior or concurrent malignancy in past 5 years except curatively treated carcinoma in situ of the cervix, breast, or basal cell or squamous cell carcinoma of the skin prior concurrent therapy: biologic therapy: not specified chemotherapy: no more than 1 prior chemotherapy or chemoradiotherapy regimen no prior gemcitabine or irinotecan endocrine therapy: not specified radiotherapy: no more than 1 prior chemoradiotherapy regimen at least 2 weeks since prior cranial radiotherapy for cns metastases no concurrent cranial radiotherapy surgery: not specified

Keywords: recurrent small cell lung cancer
the effects of mindfulness based stress reduction on patients with traumatic brain injury

Conditions: Traumatic Brain Injury; Brain Injury; Stress

Summary: this study is studying the effects of mindfulness based stress reduction (mbsr), a standard protocol of gentle yoga and breath meditation, on patients with traumatic brain injury (tbi). the investigators are testing whether this intervention can help improve the stress response and increase resiliency and mindfulness for patients with tbi, which may lead to improved symptoms and neurocognitive function.


Eligibility criteria:
inclusion criteria: * tbi \> 1 year prior to enrollment * ages 30-50 * right handed participants * history of acute inpatient rehabilitation stay of ≥ 1 night exclusion criteria: * non-english speaking (because this is a group intervention, it requires a common language) * dependent with activities of daily living (adls) * phone screen (tics-1) \> 30 * rivermead post-concussion questionnaire score \< 21 * actively practicing meditation and/or yoga or have taken a meditation/yoga class in the last 12 months * signs or symptoms of upper motor neuron syndrome * any major major systemic illness or unstable condition which could interfere with protocol compliance, including the diagnosis of major depression * active psychiatric disease that would interfere with participation in the trial * psychotic features, agitation, or behavioral problems within the last 3 months * history of alcohol/substance abuse or dependence within the past 2 years * neurosurgical intervention affecting brain parenchyma * reported sequelae from brain lesions or head trauma prior to most recent brain injury * seizure activity or treatment for seizures * use of investigational agents * participating in other clinical studies involving neuropsychological measures collected more than one time per year * any involvement in legal matters (workers' compensation, litigation, et al), past, present, or anticipated in the future, related to the tbi * unable to undergo mri for any reason such as claustrophobia, presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body
effectiveness of warm acupuncture in patients with postherpetic neuralgia

Conditions: Postherpetic Neuralgia ( PHN )

Summary: postherpetic neuralgia (phn) is the most common clinical complication of herpes zoster. phn can persist for months to years, and in some cases, the pain may last for more than five years. patients suffering from severe, prolonged pain endure significant distress, which seriously affects their quality of life and daily activities. moreover, phn can lead to insomnia, anxiety, depression, or even suicide. currently, the treatment of phn primarily focuses on pain management. first-line treatment options include gabapentin, pregabalin, tricyclic antidepressants, and 5% lidocaine patches. acupuncture is a widely used non-pharmacological therapy. a large number of clinical trials have demonstrated its effectiveness in treating various neuropathic pain conditions, including phn. acupuncture not only reduces pain perception but also alleviates anxiety and improves the quality of life for phn patients. among different acupuncture techniques, warm acupuncture (wa) is considered the most effective for treating peripheral neuropathic pain. clinical case reports have also shown its pain-relieving effects in phn patients. however, there has been no study in vietnam on the effectiveness of wa in pain reduction for patients with phn. therefore, this study is conducted to evaluate whether wa is effective in reducing pain and ensuring safety for treating phn patients with qi stagnation and blood stasis syndrome. the findings will serve as a basis for the broader application of wa in the treatment of phn.

patients with postherpetic neuralgia in the trunk area, belonging to the blood stasis syndrome. they will be treated with a combination of warm acupuncture and gabapentin. the intervention period is four weeks. warm acupuncture will be performed five times a week and gabapentin is administered daily for 4 weeks. data on the visual analog scale (vas), and side effects of warm acupuncture and gabapentin will be recorded before the study and weekly for 4 weeks.

Eligibility criteria:
inclusion criteria: * individuals with a history of herpes zoster in the trunk area. * individuals diagnosed with postherpetic neuralgia (phn) by a dermatologist, based on phn diagnostic criteria, with pain persisting for 3 months or more after the skin lesions have healed. * individuals with a pain intensity score of ≥ 3, assessed using the visual analog scale (vas). * individuals diagnosed with qi stagnation and blood stasis syndrome by a traditional medicine doctor. * individuals aged 18 years or older. * individuals who volunteer to participate in the study and sign a consent form. exclusion criteria: * active herpes zoster lesions, confirmed by the dermatologist treating the patient. * pregnant or breastfeeding women. * patients with severe cognitive impairment who cannot understand the study protocol. * patients with a history of allergy to gabapentin. * currently participating in another interventional study.

Keywords: warm acupuncture postherpetic neuralgia
effect of saphenous nerve and nerve to vastus medialis block within subsartorial femoral triangle on quadriceps strength

Conditions: Saphenous Nerve Block; Regional Anesthesia Morbidity; Postoperative Pain

Summary: this research objective is to compare quadriceps strength by measuring maximal voluntary isometric contraction (mvic) and risk of fall before and after subsartorial femoral triangle block (ssftb)


Eligibility criteria:
inclusion criteria: * eligible patients are all asa class i-iii, age 18-80 years, and have plan to perform ssftb at thammasat university hospital consecutively exclusion criteria: * exclusion criteria are patients who refuse to participate the study, morbid obesity (bmi ≥ 35 kg.m2), lower extremity neurological dysfunction, performing other peripheral nerve blocks, patients who cannot cooperate or measure mvic, difference of quadriceps strength between two side of knees more than 10 percent, and ssftb is not finally performed or failed block.
blood, urine, and tissue collection for cutaneous lymphoma, eczema, and atopic dermatitis research

Conditions: Cutaneous T-cell Lymphoma; Sezary Syndrome; Mycosis Fungoides; Eczema; Atopic Dermatitis

Summary: this is a tissue, urine, and blood banking protocol for cutaneous t-cell lymphoma (ctcl), eczema, and atopic dermatitis patients for current and future research.

the purpose of this study is to provide a central mechanism for monitoring access to peripheral blood, urine, and skin specimens obtained from ctcl, eczema, and atopic dermatitis patients to monitor: * immunologic assays/flow cytometry * tumor progression/regression * genomic studies * proteomic studies * others germane to the advancement of ctcl treatment

Eligibility criteria:
inclusion criteria: * 18 or older * able and willing to provide informed consent * diagnosed with ctcl * diagnosed with either atopic dermatitis or eczema exclusion criteria: * lack of ctcl, atopic dermatitis, or eczema diagnosis in medical record

Keywords: cutaneous t-cell lymphoma sezary syndrome mycosis fungoides blood/tissue banking eczema atopic dermatitis
acute post-radiation hyperbaric oxygen (hbo2) for breast cancer patients who have recently completed radiation therapy

Conditions: Breast Cancer

Summary: this study aims to compare patients that receive hyperbaric oxygen or trental and vitamin e immediately after completion of radiation therapy to evaluate which treatment best reduces radiation fibrosis.


Eligibility criteria:
inclusion criteria: * \> 18 years of age * patient is currently undergoing treatment for breast cancer and is on one of two pathways: * pathway 1 involves lumpectomy with radiation therapy, recurrence years later, mastectomy and tissue expander with further radiation therapy * pathway 2 involves mastectomy and tissue expander, 6 weeks of radiation therapy, and an implant in 6 months * undergone mastectomy with expander or implant reconstruction \> 2 weeks before starting radiation therapy * completed chest wall irradiation in the past 3 days * willing to stop herbal medications as directed by provider * willing to stop daily use of supplemental vitamin e (multivitamin with vitamin e component is acceptable, vitamin e cream is also acceptable) * willing to have photographs of chest area taken for research purposes only * therapeutic pt-inr for participants taking coumadin * if tissue expanders remain intact during radiation, plan for conversion to the final implants must occur \> 4 months after completing radiation * willing to travel to a legacy health facility for study related visits * agree to attend study visits outside of standard of care visits, if needed * willing to engage in pre/post testing and survey/phone calls * willing to attend all 6 weeks of hbot if randomized to that group exclusion criteria: * \< 18 years of age * pregnant or lactating * have final implant placed \< 2 weeks before start of radiation therapy * plan to place final impacts \< 4 months from the completion of radiation therapy, if tissue expanders are intact during radiation therapy * have evidence of ongoing infection or implant exposure before start of radiation therapy * radiation completed more than 3 days prior to study start * unable to comply with protocol * unable to provide written informed consent * unwilling or unable to stop oral supplemental vitamin e * pt-inr outside of acceptable range for participants taking coumadin * any delay in radiation treatment greater than 14 days * investigator does not believe study participation is in the best interest of the patient * history of a seizure within the last 5 years