Kornimate/medical-research-clean huggingface dataset:
stereotactic intracerebral injection of ipsc-daps in patients with parkinson's disease

Conditions: Parkinson Disease

Summary: parkinson's disease is a progressive neurodegenerative disorder characterized by high morbidity due to the limited regenerative capacity of dopaminergic neurons in the brain. current drug treatments primarily manage symptoms but do not halt or reverse neuronal loss. cellular replacement therapy has emerged as a potential strategy to restore dopaminergic function and address the underlying neuronal deficits. this study aims to evaluate the safety, feasibility, and efficacy of transplanting dopaminergic neurons into the brain to improve motor function and quality of life in patients with advanced parkinson's disease.

patients with parkinson's disease will be treated with autologous induced pluripotent stem cell-derived dopamine progenitor cells (ipsc-daps). these cells will be transplanted directly into the striatum to restore dopamine-producing capacity. patients will be evaluated at 1, 3, 6, 9 and 12 months after transplantation for safety, feasibility, and efficacy.

Eligibility criteria:
inclusion criteria: * able to sign informed consent and comply with the study protocol * 39-75 years of age, at the time of signing informed consent * diagnosed to be parkinson's disease patients over 5 years * taking levodopa, but with complications of therapy such as wearing off and/or dyskinesia * at least 3 hours accumulative "off" time per day * hoehn and yahr stage 2.5 - 4 in the off state at screening * dopamine drug responsiveness demonstrated by a positive "on/off" test with at least a 30% improvement on updrs iii (motor) scale exclusion criteria: * patients with the following concomitant conditions or disorders: epilepsy；multiple sclerosis；unable to give consent due to dementia；atypical parkinsonism；genetic parkinson's disease；suicidal ideation associated with intent or plan in the past 12 months；history of psychosis；history of subarachnoid hemorrhage；history of stroke or transient ischemic attack * patient with unstable vital sign at screening and/or prior to the surgery: * estimated glomerular filtration rate (egfr) \< 60 ml/min/1.73m2 * liver dysfunction, as evidenced by enzymes (ast and alt) greater than three times the uln. * hematologic abnormality: hemoglobin \<10 mg/dl or platelet count \< 100,000/ml * international normalized ratio (inr) ≥ 1.3 not due to a reversible cause * patients with autoimmune disorders * patients with hiv and/or active hbv or hcv * patients who are unable to undergo mri and pet/ct * patients with an expected life expectancy of \<1 year * patients who have had active malignancies * patients currently receive levodopa-carbidopa intestinal gel or apomorphine treatment * patients who have history of pallidotomy or thalamotomy or deep brain stimulation (dbs) surgery * received cell or gene therapy (autologous or allogeneic) within the previous 12 months * participation in an investigational therapeutic or device trial within 30 days of consent * women who are pregnant or breast-feeding * other conditions that researchers consider not suitable to participate in this study
pr-conceptional progesterone for unexplained recurrent miscarriage

Conditions: Abortion, Habitual

Summary: in women with unexplained recurrent miscarriages, progesterone (400 mg pessaries, twice daily), started soon as possible at luteal phase and after a positive pregnancy test and continued to 28 weeks of gestation, compared to placebo, ).

progesterone improves secondary outcomes such as gestation at delivery, on-going pregnancy at 12 weeks, survival at 28 days of neonatal life. . progesterone, compared to placebo, does not incur substantial adverse effects to the mother or the neonate. explore differential or subgroup effects of progesterone in prognostic subgroups. . perform an economic evaluation for cost-effectiveness.

Eligibility criteria:
inclusion criteria: 1. women with unexplained recurrent miscarriages (2 or more consecutive first trimester miscarriages). 2. age 18-39 years at randomisation (likelihood of miscarriages due to chromosomal aberrations is higher in older women; such miscarriages are unlikely to be prevented by progesterone therapy). 3. spontaneous conception (as confirmed by urinary pregnancy tests). 4. willing and able to give informed consent. exclusion criteria: 1. age less than twenty or above forty years old. 2. antiphospholipid syndrome (lupus anticoagulant and/or anticardiolipin antibodies \[igg or igm\]); other recognised thrombophilic conditions (testing according to usual clinic practice) 3. intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy). 4. fibroids distorting uterine cavity. 5. abnormal parental karyotype. 6. other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (sle).

Keywords: recurrent miscarriages progesterone
immediate and flapless full-arch rehabilitation of edentulous jaws

Conditions: Edentulous Patients

Summary: the study involved 28 edentulous patients (20 female/8 males; average age of 67.75± 8.627 years) rehabilitated with 33 prostheses (17 all-on-4/16 all-on-6) supported by 164 implants.

clinical and radiographic outcomes were implants survival, prostheses success/survival, implant marginal bone loss, incidence of biological and prosthetic complications.

Eligibility criteria:
inclusion criteria * mandibles or maxillae edentulous or with hopeless teeth; * patient's request of fixed implant restorations * patients in general good health (asa-1/asa-2) exclusion criteria * compromised systemic conditions; * head/neck irradiation or chemotherapy within 2 years; * bisphosphonate therapy; * metabolic bone diseases; * insufficient bone volume; * mouth opening less than 50 mm inadequate to place surgical instrumentations. * history of periodontitis or smoking habit were not considered exclusion criteria.

Keywords: full- arch implant prosthesis flapless implant surgery immediate dental implant loading surgery computer-assisted dental implants template-guided surgery all on four all on six ; tilted implants
surgical emergency flows and delays in admission to the operating room

Conditions: Surgery; Emergencies; Postoperative Complications

Summary: french hospitals treat non-elective surgery according to three organizational models: in a dedicated multi-specialty emergency operative room (or), in a dedicated or within a specialized surgical platform or in any available or from a list of non-dedicated or. some triage algorithms for the classification of non-elective surgery have been described but are not routinely applied. the rate of delay in the management of non-elective surgery in france is not known. reducing this delay decreased mortality and morbidity in urgent surgery (mcisaac d, et al., cmaj 2017). optimizing the flow of non-elective surgery represents a major challenge. the main objective of this study is to determine the rate of delay in admission to the or in emergency surgery through a multicenter prospective observational study in france. all patients requiring urgent surgical management (\ 1.


Eligibility criteria:
inclusion criteria: any patient meeting the following two criteria * at least 18 ys old * decision for unplanned surgery (which should be performed within 72 hours according to the protocol) * in one of the following hospitals: lille university hospital, grenoble university hospital, strasbourg university hospital, paris university hospitals (européen georges pompidou, beaujon, h. mondor), lyon university hospital (hôpital e. herriot, lyon sud), angers university hospital, anthony private hospital). exclusion criteria: * obstetrics * interventional radiology * endoscopies

Keywords: delay organization
cognition and magnetic resonance imaging of brain inflammation in obesity

Conditions: Obesity

Summary: the rate of obesity in the united states is high and is a risk factor for concurrent cognitive impairment and, in late life, dementias such as alzheimer's disease. in order to prevent or reduce cognitive impairment, the mechanism underlying the link between obesity and cognitive impairment must be understood. the current study aims to provide preliminary data on whether brain inflammation occurs in obesity and relates to cognitive deficits using magnetic resonance neuroimaging and cognitive testing. it is hypothesized that obese individuals will have greater brain inflammation and lower cognitive function compared to normal-weight individuals. further, it is predicted that brain inflammation will relate to cognitive function and plasma indicators of inflammation in obese individuals.

initially, normal-weight or obese potential participants are screened by a phone interview that assesses medical history. obtainment of informed consent and further screening occurs on the day of the study visit. participants then undergo a 2 hour oral glucose tolerance test (ogtt) including blood draws for metabolic and inflammatory marker levels in plasma. lunch is then provided. participants are then administered 30 minute computer-based cognitive testing from the nih toolbox cognition battery. after cognitive testing, participants undergo 1.5 hour magnetic resonance imaging (mri) that includes structural, diffusion tensor, and functional mr imaging.

Eligibility criteria:
inclusion criteria: * non-obese (body mass index = 18 - 25 kg/m\^2) or obese (body mass index ≥ 30 kg/m\^2 * any race or ethnicity * native english speaker exclusion criteria: * past or current diabetes * current psychotropic medication use * past or current neurological illness * past or current substance or alcohol misuse * past or current mental illness * current binge eating disorder * magnetic resonance imaging contraindications * pregnancy * currently lactating * tobacco use within past month * over 350 lb

Keywords: obesity inflammation cognitive impairment neuroimaging magnetic resonance imaging
teamcare for diabetes in mental health centers

Conditions: Diabetes

Summary: this proposal aims to demonstrate the feasibility and acceptability of adapting teamcare for patients with schizophrenia. the aim of this innovative mental health center-based team intervention is to improve diabetes, cardiovascular and psychiatric outcomes among patients with poorly controlled type 2 diabetes. the study will be conducted in two phases over the 2-year grant period. phase 1. development of the adapted teamcare intervention and training of team members. phase 2. during year 2, we will implement the intervention on the caseload of 40 outpatients at harborview mental health services with schizophrenia and poorly controlled type 2 diabetes. the intervention involves the management of subjects' diabetes, hypertension, and hyperlipidemia by a cmhc diabetes team for 6 months (advanced nurse specialist on-site at supervised in weekly meetings by a psychiatrist and a uw diabetes center endocrinologist). the primary aim of this pilot research grant is to evaluate the feasibility of implementing this complex intervention, in order to guide the design of a larger scale efficacy study (r01). both process and outcome measures will be evaluated at baseline, and at 3- and 6-month follow-up visits for the 40 subjects enrolled in this feasibility trial.


Eligibility criteria:
inclusion criteria: * adult (18-70 years); * enrolled to receive mental health treatment at harborview mental health services or downtown emergency services mental health center * a diagnosis of type 2 diabetes mellitus or cardiovascular disease * hemoglobin a1c \>8 or bp \> 140/90 exclusion criteria: * cognitive, hearing, or language impairment that would preclude a subject from providing informed consent; * current suicidality, homicidality, or grave disability that requires psychiatric hospitalization; * current substance abuse or dependence, as defined by scid.
covid-19 serological status of hospital staff working or not in the covid-19 sector

Conditions: Infection Viral

Summary: hospital staff, on the front line in the covid-19 crisis, have many questions about the risk that they have been infected with this potentially fatal virus. these questions of course primarily concern caregivers working in sectors dedicated to covid-19 patients, whether they are resuscitating or not, but also those in non-covid-19 sectors, or even staff without direct contact with patients. in addition, depending on the suddenness and intensity of this "covid-19 wave", these personnel have been more or less trained and sometimes exposed due to the dire lack of protective equipment. in some countries such as great britain, this has resulted in significant absenteeism, a source of deepening the shortage of caregivers. this proportion of contaminated caregivers has not been evaluated on the whole of french territory. studies from other countries suggest figures ranging from 1.5% in china to 20% in italy. it is therefore impossible to rely on such variable data to have a reliable estimate. since june 2020, all staff in french health establishments could benefit a serological test. thus, in this epidemiological study, we propose to rely on this institutional serological screening to describe the link between seroconversion of hospital staff, regional intensity of the epidemic, and sectors of activity (covid-19 sectors, non-covid-19 caregivers , non-covid-19 non-caregivers.


Eligibility criteria:
inclusion criteria: * hospital staff from argenteuil, belfort, dijon and limoges hospitals. * age ≥ 18 years old * participation agreement exclusion criteria: * protected persons * refusal of participation
study of nms-1286937 in adult patients with advanced/metastatic solid tumors

Conditions: Advanced or Metastatic Solid Tumors

Summary: the purpose of this study is to evaluate the safety and tolerability of nms-1286937, a polo-like-kinase 1 inhibitor, in patients with advanced metastatic solid tumor.


Eligibility criteria:
inclusion criteria: * advanced/metastatic solid tumors, for which no effective standard therapy exist * adult patients (age \>/= 18) * ecog performance status (ps) 0 or 1 * life expectancy of at least 3 months * adequate renal, liver function and bone marrow reserve * prior cancer therapy allowed, with max 4 regimens of chemotherapy. washout: at least 4 wks (6 wks for nitrosoureas, mitomycin c and liposomal doxorubicin) and all toxicities recovered to ctc grade \</=1 * prior radiotherapy allowed if no more than 25% of bm reserve irradiated * women and men of child producing potential should agree to use effective contraception * capability to swallow capsules intact exclusion criteria: * known uncontrolled/symptomatic brain metastases * currently active second malignancy * major surgery in the last 4 wks * any of the following in the past 6 months: myocardial infarction, unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein thrombosis * pregnancy or breast-feeding women * known active infections * history of drug allergic reactions * gastrointestinal disease or other malabsorption syndromes that would impact on drug absorption. * documented gastrointestinal ulcer * other severe concurrent acute or chronic medical or psychiatric condition that could compromise protocol objectives

Keywords: phase i dose escalation study advanced or metastatic solid tumors plk 1 inhibitor adult patients
clinical research on the efficacy of acupuncture treatment in chronic low back pain

Conditions: Chronic Low Back Pain; Acupuncture

Summary: this research is planned to build a basis about effect of acupuncture for chronic low back pain with economical efficacy. it is consisted with two sub research. first,clinical research to know the effect of acupuncture for chronic low back pain will be processed with acclate, randomized, patient, outcome-assessor masking. 130 subjects would be collected and devided into two groups(experimental and placebo). experimental group will undergo with real acupunture treatment twice a week, for 6 weeks and acupuncture spots would be selected for each person by clinical specialist. placebo group will undergo with park-sham needle and same 8 acupuncture spots would be used for all subjects also twice a week, for 6 weeks. the effect will be accessed by vas, x-ray, odi, sf-36, eq-5d, bdi before and the last treatments. second is qualitative research to make a basis through the economic evaluation and satisfaction of acupuncture treatment for chronic low back pain. 15 persons who have been treated at oriental medical hospital for chronic low back pain and 15 in experimental group and 15 in placebo group who participate the clinical research will be collected and through the personal interview, satisfaction about the treatment and economic efficacy will be evaluated.


Eligibility criteria:
inclusion criteria: * the person who have been undergo chronic low back pain for chief complain over 3 months. * the person whose age is from 18 to 65. * the person who are normal in neurology examination. * the person whose bothersomeness for the last week before the participation of the treatment is over vas 5. * the person who are diagnosed as nonspecific loe back pain. exclusion criteria: * the person who have radicular pain. * the person who are diagnosed as specific disease which cause low back pain such as metastatic cancer, vertebral fracture, spinal infection, inflammatory spondylitis. * the person who are diagnosed as other chronic disease which could affect the result such as caediovascular disease, diabetic neurophaty, active hepatitis, fibromyalagia, rheumatic arthritis, dementia, hemorrhagic disease, epilepsy. * the person who have had or would have spinal surgery. * the person who have other skeletomuscular pain as chief complain. * the person who have been treated acupuncture treatment for low back pain last 1 month. * the person who is taking corticosteroids, narcotics, muscle relaxant,anticoagulant drug, herb-med for low back pain, or other non-propal drugs.

Keywords: acupuncture chronic low back pain qualitative study
checklists and upright positioning in endotracheal intubation of critically ill patients (check-up) trial

Conditions: Respiratory Failure

Summary: the use of a written, pre-procedure checklist and positioning the patient with the head of the bed elevated have been proposed as interventions capable of preventing complications during non-elective intubation and are used intermittently in routine care -- however neither have been examined in a prospective trial.

endotracheal intubation is common in the care of critically ill patients. procedural complications including hypoxia and hypotension are frequent in urgent and emergent intubation and associated with an increased risk of death. the use of a written, pre-procedure checklist and positioning the patient with the head of the bed elevated have been proposed as interventions capable of preventing complications during non-elective intubation and are used intermittently in routine care -- however neither have been examined in a prospective trial. the investigators propose a randomized trial comparing use of a written checklist versus no written checklist and ramped versus sniffing position for endotracheal intubation of critically ill adults.

Eligibility criteria:
inclusion criteria: airway management events will be included in which: 1. patient is admitted to the medical intensive care unit (micu) 2. planned procedure is endotracheal intubation 3. planned operator is a pulmonary and critical care medicine (pccm) fellow 4. administration of sedation and/or neuromuscular blockade is planned 5. age ≥ 18 years old exclusion criteria: airway management events will be excluded in which: 1. operator feels specific patient positioning during intubation is required 2. urgency of intubation precludes safe performance of study procedures 3. operator feels an alternative pre-procedure checklist or no checklist is required

Keywords: endotracheal intubation checklist positioning
exercise training and metabolic flexibility in prediabetes

Conditions: PreDiabetes; Sedentary Lifestyle

Summary: the purpose of the study is to determine if a 6-week exercise training program promotes exercise-induced metabolic flexibility, that is, the ability to switch fuel sources for energy, in older prediabetic adults.

this is an investigator initiated single group intervention trial. all participants will receive a 6-week exercise training program with testing occurring before and following the training program. participants will be provided with 3 days of a high fat diet prior to each of the three testing sessions at the clinical research unit. all who agree to participate will undergo the same intervention. the goal of this proposal is to study the impact of a 6-week moderate intensity walking training program on exercise induced lipid metabolic flexibility in older adults with prediabetes. study investigators will seek to determine if exercise induced lipid oxidation following a high fat diet is increased in trained individuals relative to their baseline.

Eligibility criteria:
inclusion criteria: * ≥60 years of age * sedentary prior to the start of the training program (self-reported: less than 30 minutes of exercise for no more than 1 day a week) * prediabetes (measured at first screening: hba1c = 5.7-6.5%) * must be able to pick-up and consume study provided foods * willingness to provide informed consent and participate in the intervention * must obtain transportation to visits and intervention training sessions * no contraindications for involvement in a moderate exercise training program or exercise testing procedures by self-report exclusion criteria: * self-reported diagnosis of a metabolic or chronic disease such as cardiovascular disease, diabetes, chronic obstructive pulmonary disease, or movement disorders such as parkinson's disease, ataxia, huntington's disease * current or recent (\<12 months) treatment for cancer * body mass index \ /30.0 kg/m2 * tobacco users * febrile or chronic infection within study period * aversion to testing procedures * hypertension, hyperthyroidism, hypothyroidism * unwilling to abstain from ingesting caffeine during study testing periods * unwilling to withhold medications that affect metabolic rate during testing periods * physically active (\>30 minutes per day on more than 1 day per week) * ecgs that indicate cardiac injury or contraindications to treadmill testing * allergic or intolerant to any study-provided foods

Keywords: metabolic flexibility exercise induced metabolic flexibility