Kornimate/medical-research-clean huggingface dataset:
a self-management based survivorship intervention for chinese cancer survivors

Conditions: Physical Symptom Distress; Weight Management; Neoplasms

Summary: this study, using a sequential multiple assessment randomized controlled trial (smart) approach, will evaluate a cancer survivorship care intervention on physical symptom distress, weight management, self-efficacy in managing cancer and health-related quality of life among chinese patients recently completed curative cancer treatment.

this study, using this smart approach, will assess the effect of a cancer survivorship care intervention on physical symptom distress, self-efficacy in managing cancer, weight management and health-related quality of life among chinese patients recently completing curative cancer treatment. first, the investigators will test the effect of a one-off, multidisciplinary team face-to-face assessment (namely, the cancer survivorship clinic) with personalized advice on symptom management, lifestyle modification and anxiety management in reducing the case prevalence of symptom distress, increasing the proportion meeting the weight management criteria, and improving self-efficacy and health-related quality of life among cancer survivors in post-treatment survivorship, in comparison to those receiving skills-based pamphlets for symptom management and lifestyle recommendations. secondly, this study aims to explore if a step-up targeted personalized intervention is more effective for patients who continue to have symptom distress and/or not to meet the weight management criteria if patients have attended cancer survivorship clinic (i.e. the embedded adaptive intervention) in comparison to those receiving skills-based pamphlets.

Eligibility criteria:
inclusion criteria: * cantonese- or mandarin-speaking chinese patients diagnosed curable cancer * have completed primary and adjuvant treatment within the past six months exclusion criteria: * patients diagnosed with metastatic cancer

Keywords: physical symptom distress weight management self-efficacy in managing cancer health-related quality of life survivorship intervention sequential multiple assessment randomized controlled trial psychooncology
a study to evaluate once-daily oral vt-464 in patients with castration-resistant prostate cancer

Conditions: Castration-resistant Prostate Cancer; CRPC

Summary: the goal of this clinical study is to determine the safety, tolerability, pharmacokinetics and activity of once-daily (qd) oral dosing of vt-464, a lyase-selective inhibitor of cyp17, in patients with castration-resistant prostate cancer (crpc).

this is a phase 1/2 study of vt-464 in chemotherapy-naïve crpc patients who are treatment-naive or who have failed prior therapy with abiraterone and/or enzalutamide. the study will examine several parallel qd dosing regimens of vt-464 using a traditional modified "3+3" fibonacci study design. approximately 3 dose-levels of vt-464 will be examined in each dosing regimen that is fully enrolled.

Eligibility criteria:
key inclusion criteria: * patients must have documented histological or cytological evidence of adenocarcinoma of the prostate. * patients must have a minimum serum psa level of \>2 ng/ml that is rising based on the prostate cancer working group 2 criteria. * patients must have castrate levels of testosterone (\<50 ng/dl \[1.74 nmol/l\]). * patients must have undergone orchiectomy, or have been on lhrh agonists or antagonists, for at least 3 months prior to study entry. patients on lhrh agonists/antagonists must remain on these agents for the duration of the study. * patients must have an ecog performance score of 0 or 1. key exclusion criteria: * patients who have received prior cytotoxic chemotherapy for castration-resistant prostate cancer unless enrolled in a previous chemotherapy cohort. * patients who have received second-line antihormonal therapy, including ketoconazole, aminoglutethimide, or high-dose estrogen within 30 days of study entry. * patients who have completed sipuleucel-t (provenge ®) treatment within 30 days of study entry. * patients who have received tok-001 (galeterone®) or any other investigational product directed towards the androgen receptor or androgen biosynthesis. * patients who have received antiandrogens such as flutamide (eulexin®), bicalutamide (casodex®), or nilutamide (nilandron®) for \> 3 months must be off treatment for 6 weeks and demonstrate a continued rise in psa after withdrawal. patients on antiandrogens for \< 3 months must be off medication for 2 weeks. patients on 5 alpha reductase inhibitors such as finasteride (proscar®, propecia®), or dutasteride (avodart®) must stop medication at least 3 months from study entry. * patients who require pharmacological or replacement doses of systemic corticosteroids or who have received systemic corticosteroids within 30 days of study entry; use of topical, inhaled or ophthalmic steroids is permitted. * patients who have received palliative radiotherapy within 4 weeks of study entry. * patients with a history within the last 3 years of another invasive malignancy.

Keywords: castration-resistant prostate cancer cyp17 p450c17a lyase
transcranial ultrasonography using linear 2d imaging of the brain

Conditions: Autism; Extra-axial Fluid

Summary: this study will use linear 2d ultrasound imaging to look at the brain of individuals diagnosed with autism and their siblings. this is called transcranial ultrasound (tus). it is hypothesized that tus will allow real-time imaging of the fluid spaces outside the brain and will further allow the imagining of brain areas important to language and social function.

tus will be evaluated as a simple and low cost screening technique to evaluate the presence of increased extra-axial fluid (eaf)or(subarachnoid cerebral spinal fluid). a recent study (shen et al. 2013) demonstrated increased eaf was predictive of risk of autism. we believe tus is capable or rapid, safe, low cost, non-invasive measurement of eaf spaces. where prior imaging, ie., mri or ct exist they will be used as comparisons. both individuals with autism and their siblings will be screened to create a database and standard for tus measurements. it is further believed that tus may be able to detect areas of cortical abnormalities called dysplasias. the procedure requires no sedation and only takes a few minutes to perform. if validated, this would make tus an ideal screening test for autism risk and allow for early referral and more definitive imaging with mri where necessary.

Eligibility criteria:
inclusion criteria: confirmed diagnosis of autism or the sibling thereof and willingness of a parent to consent and where applicable for the individual to assent or consent depending on age. - exclusion criteria: siblings must have no obvious health issues or developmental abnormalities. -

Keywords: transcranial ultrasound autism cortical dysplasia extra-axial fluid
online mindfulness training versus health education for fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of this study is to compare an online 12-module intervention designed to improve emotion regulation and social relations via mindfulness training with a 12-module program that provides information about health behaviors to individuals with fibromyalgia. the mindfulness training program is expected to produce greater day-to-day improvements than the education condition in individuals' efficacy for coping with pain and stress, positive and negative affect, and positive engagement in social relations assessed via online diaries completed each evening during the intervention period.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * self-report of physician diagnosis of fibromyalgia * able to read and understand english * daily access to the internet exclusion criteria: * self-report of more than 5 past episodes of depression

Keywords: fibromyalgia mindfulness on-line intervention chronic pain
continuous glucose monitoring (poc) in the icu

Conditions: Burns; Trauma

Summary: the purpose of this study is to prospectively evaluate whether the addition of continuous glucose monitoring to point-of-care (poc) glucometer monitoring improves glucose control.

severe burns and traumatic injury can be associated with protracted illness and prolonged icu course. the beneficial effects of strict serum glucose control in critically ill surgical patients have been demonstrated. continuous glucose monitors may improve glucose control by providing close to real-time glucose measurements, giving the critical care team the ability to react to trends before hypo- or hyperglycemia is reached. these improvements may decrease the morbidity and mortality associated with severe thermal injury, thereby minimizing hospital stay and recovery. burned and injured soldiers, airmen, sailors, and marines may return to duty in a more expeditious fashion, or at minimum, enjoy a better quality of life after discharge from the intensive care unit.

Eligibility criteria:
inclusion criteria: * remain 1 week in an icu * 18-72 years old * severe trauma or thermal injury greater than 20% tbsa burn exclusion criteria: * cerebral arterial injury * myocardial infarction * pre-existing renal failure or liver failure * history of hypoglycemia * history or high risk of seizures * pregnancy

Keywords: severe burns severe trauma closed loop insulin continuous glucose monitoring