Kornimate/medical-research-clean huggingface dataset:
objective and subjective outcomes of an electronic chest drainage system

Conditions: Lung Cancer

Summary: this study is designed to compare the thopaz chest tube drainage system to the traditional collection chamber system. the thopaz system is already in clinical use in the united states and throughout the world. as such, this study is not evaluating safety or efficacy of this system both of which have already been demonstrated. this study's primary aim is to determine whether the use of a digital chest drainage system compared with a traditional system affects duration of chest drainage and length of hospital stay. furthermore, we aim to determine whether the use of a digital chest drainage system compared with a traditional system increases the total distance of ambulation in the first 48 hours after thoracic surgery and affects overall patient satisfaction in the peri-operative period. finally, we want to determine whether the aforementioned outcomes relative to the chest tube drainage systems differ in different parts of the world.


Eligibility criteria:
inclusion criteria: 1. able and willing to read, understand, and provide written informed consent 2. age range of 18-90 years 3. patients undergoing a segmentectomy, lobectomy, or bilobectomy. both open and minimally invasive (thoracoscopic or robotic) resections are acceptable. exclusion criteria: 1. patients unstable enough to require icu care upon completion of the resection 2. redo thoracotomies

Keywords: chest tube lung resection patient satisfaction mobility
real-time reminders to decrease late or missed meal boluses

Conditions: Type1 Diabetes Mellitus

Summary: this study is examining whether the klue app is effective in detecting missed or late meal boluses in patients with type 1 diabetes. the app is programmed onto an apple watch and will detect potential missed boluses from hand motion. it will send text alerts to the user asking if they have bolused. this is a pilot study and will assess whether there is a change in the number of missed meal boluses in the two weeks prior to each visit. if the findings are significant, this software can be integrated in future closed-loop algorithms for automatic insulin delivery.

this will be a randomized, cross-over, unblinded study with subjects randomized upon entry into the study to either begin using the klue software for 6 weeks or to continue with their usual care for 6 weeks. subjects are eligible for enrollment if they are using a continuous glucose monitor (cgm) and insulin pumps or an insulin pen with memory and cgm, are missing or late in giving at least 4 food boluses in the previous two weeks, and they have an iphone. missing or late meal boluses will be assessed through their pump/pen and sensor downloads. this is a pilot study. the investigators do not have preliminary data to do a true power calculation. the primary outcome will be the change in the number of missed meal boluses in the two weeks prior to each visit. secondary outcome measures will be the number of missed meal boluses in each month of the study, change in hba1c levels (measured every 6 weeks), accuracy of the klue software in detecting meals (true positive and false positive rates), and a user satisfaction survey.

Eligibility criteria:
inclusion criteria: 1. age 13 and over 2. on an insulin pump for at least 3 months and using cgm or using an insulin pen with memory and a cgm 3. willing to wear a cgm at least 70% of the time while in the study 4. using an iphone 5. willing to wear an apple watch on their dominant hand while awake 6. missing or late in giving at least four food boluses in the previous two weeks 7. understanding and willingness to follow the protocol and sign informed consent 8. ability to speak, read and write in the language of the investigators exclusion criteria: 1. pregnant or lactating 2. a known medical condition that in the judgment of the investigator might interfere with the completion of the protocol 3. current treatment for a seizure disorder 4. inpatient psychiatric treatment in the past 6 months note: adequately treated thyroid disease and celiac disease do not exclude subjects from enrollment. they may be participating in another trial, if this study is approved by the investigators of the other trial.
systematic ultrasound in the initial assessment of ankle sprain

Conditions: Ankle Sprain

Summary: ankle sprains are the most frequently encountered trauma in emergency and general medicine. lateral ankle sprain injuries have the highest relapse rate of all musculoskeletal injuries of the lower limbs. optimal initial management is essential for a successful return to previous condition, with the aim of preventing chronic ankle instability, chronic pain, stiffness or recurrence. one of the 13 physicians at our facility routinely performs an ultrasound routinely scan during the second consultation to assess the severity of the sprain. we would therefore like to evaluate whether the performance of this examination at the time of clinical reassessment is associated with a better prognosis at 3 months post-trauma.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ankle sprain made during a preliminary prior consultation * patients undergoing re-evaluation of sprain severity, between d3 and d6 of trauma exclusion criteria: * medial sprain * sprain recurrence \<6 months * age \< 15 years * radiographic fracture confirmed on an x-ray performed between initial diagnosis and re-evaluation visit * history of hyperlaxity syndrome

Keywords: ultrasound scan
squatting on the toilet and capsule endoscopy

Conditions: Intestinal Diseases

Summary: this study evaluates the effect of squatting on the toilet on gastric transit time and complete examination rate of capsule endoscopy.in the observation group, the patients could go to squatting on the toilet at any time as they want to after taking the capsule.

the subjects were divided into a control group and an observation group according to whether the patient squatted in the toilet, in the control group, the patients took discontinuous right lateral position, walked on a flat road and climbed the stairs alternately. in the observation group, in addition to the above ways, the patients could go to squatting on the toilet at any time in the first hour after taking the capsule. the operator observed the position of capsule every one hour. the examination was over when capsule endoscopy entered the colon. if the capsule remained in the small intestine, the examination continued until the capsule ran out of power.

Eligibility criteria:
inclusion criteria: * unexplained gastrointestinal bleeding, unexplained chronic abdominal pain and diarrhea, suspected crohn's disease, suspected small intestinal tumor, and patients needing to exclude small intestinal diseases. exclusion criteria: * suspected intestinal obstruction and intestinal stenosis, esophageal stenosis or dysphagia, history of abdominal operation, or diabetes mellitus.

Keywords: squatting on the toilet capsule endoscopy
the impact of perioperative transfusion on postoperative cognitive dysfunction

Conditions: POCD; Anemia; Transfusion

Summary: although blood transfusion is a representative treatment for acute anemia due to blood loss during surgery, it is also a powerful risk factor for postoperative cognitive dysfunction. 'restrictive transfusion', which transfusions minimal red blood cells, is not only useful for conserving limited blood resources, but also does not worsen prognosis or mortality after surgery. research has also been reported that severe restrictive transfusion has improved prognosis and mortality. however, anemia is also one of the risk factors for postoperative complications, including neurocognitive impairment, it is still controversial how much anemia should be allowed in elderly people who are sensitive to ischemia or heart disease. the purpose of this study is to determine whether the restrictive transfusion policy reduces the frequency of postoperative cognitive dysfunction than the liberal transfusion policy in patients aged 65 years or older who undergo lumbar interbody fusion. restrictive transfusion strategy (which initiates transfusion when hemoglobin level is less than 8 g / dl during perioperative period) // liberal transfusion strategy (which initiates transfusion when hemoglobin level is less than 10 g / dl during perioperative period)

the aim of this study was to compare the frequency of postoperative cognitive dysfunction diagnosed 7 days after surgery between two groups. k-moca (korean-montreal cognitive assessment) is used to evaluate cognitive dysfunction. in addition, plasma inflammatory markers (crp, il-6) and gfap reflecting brain damage were measured before and after surgery to determine whether brain injury caused by systemic inflammatory response is associated with cognitive dysfunction

Eligibility criteria:
inclusion criteria: * patients 65 years of age or older who receive more than two levels of lumbar interbody fusion exclusion criteria: * if patients have anemia (hb is less than 13 g / dl for men and less than 12 g / dl for women) * those who cannot read the agreement (illiteracy, foreigner, etc.) * have a history of taking medication for mental illness * communication disorders due to neurological diseases (dementia, stroke, seizures, etc.) * less than 23 points on k-moca test * when fluid loading and volulyte are difficult due to kidney disease * limited blood transfusion due to heart disease * refusal of blood transfusions (religious reasons, etc.) * patients who have received a blood transfusion within 6 weeks prior to surgery * if continuous observation is impossible after surgery * emergency surgery
prospr/pcips project 3: communication of personalized breast cancer risk

Conditions: Breast Cancer

Summary: in order to better communicate personal risk of breast cancer to women who have not yet initiated breast cancer screening (mammography), the annenberg school of communication at the university of pennsylvania has created a personal breast cancer screening decision aid tool. this tool will be pilot tested, and then implemented and tested in nine primary care and ob/gyn practices within the university of pennsylvania health system.

in order to better communicate personal risk of breast cancer to women who have not yet initiated breast cancer screening (mammography), the annenberg school of communication at the university of pennsylvania has created a personal breast cancer screening decision aid tool. this tool incorporates questions about a women's personal history of breast cancer and compares her to the average women her age in terms of breast cancer risk. the tool helps the women to understand the benefits and risks of breast cancer screening. this tool will be pilot tested using ssi to help develop the final version of the decision aid tool. the decision aid tool will then be implemented and tested in nine general internal medicine, family medicine, and ob/gyn practices within the university of pennsylvania health system.

Eligibility criteria:
inclusion criteria: * women ages 39-48 * patient of one of the nine primary care or ob/gyn practices that are participating in the study * must have had an appointment at one of these locations in the past 24 months * must have an appointment during the study period * woman has not yet initiated breast cancer screening (no prior mammogram) * no history of breast cancer exclusion criteria: * prior diagnosis of breast cancer * major comorbidity that substantially affects their 10 year mortality * non-english speaker
pirfenidone in progressive interstitial lung disease associated with clinically amyopathic dermatomyositis

Conditions: Dermatopolymyositis; Interstitial Lung Disease

Summary: interstitial lung disease (ild) is a common complication of dermatomyositis (dm) with prevalence up to 65%, and is considered to be one of the determining factors of prognosis. clinical amyopathic dermatomyositis (cadm), which is a special phenotype of dm, with characteristic cutaneous manifestations but no or only subclinical myopathy. many studies, mainly from asia, including ours, have demonstrated that these patients with cadm tend to develop a rapidly progressive ild (rpild) and have a poor response to conventional therapy, such as high-dose corticosteroids and immunosuppressants, leading to lethal outcome with a 6-month survival rate of less than 50%. pirfenidone, a new oral antifibrotic agent, has been approved for the treatment of idiopathic pulmonary fibrosis (ipf). randomized controlled trials of pirfenidone in patients with ipf suggested that it could ameliorate pulmonary function decline and improve the progression-free survival. its utility in connective tissue disease (ctd) related ild has been implicated, but no evidence has yet demonstrated its efficacy. therefore, the investigators conduct this study to evaluate the possible therapeutic effects of pirfenidone on rpild associated with cadm.


Eligibility criteria:
inclusion criteria: * willingness of the subject to participate in the study, proven by signing the informed consent; * all participants fulfilled the provisional diagnosis of cadm according to the modified sontheimer's criteria. * the course of ild is longer than 3 months, but shorter than 6 months, presenting as increase in level of dyspnea, and worsening of fibrosis on pulmonary hrct with \>10% increase of hrct score, and/or decrease in %fvc by \>10% absolute value. exclusion criteria: * participants who are unwilling to sign the inform consent; * the course of participants ever treated with biologics including basiliximab, or malignancy-associated cadm or overlapped with other ctd, or with alanine transaminase more than 2 times the upper normal limits; * pregnancy or lactation.

Keywords: dermatopolymyositis interstitial lung disease pirfenidone
herbal patch for overactive bladder

Conditions: Overactive Bladder Syndrome

Summary: overactive bladder is a clinical syndrome characterized by frequency, with or without urge incontinence, urgency, and nocturia, which affect patients' sleeping quality and rehabilitation program progressing. current treatments include behavioral therapy (eg, life style adjustment, bladder training, pelvic floor muscle therapy) and medication. antimuscarinic agents is the most common medications prescribed for oab, but patients often have side effects like dry mouth and constipation. and there were plenty of herbal medicine which are beneficial to urine frequency and voiding dysfunction in ancient chinese medicine books and records. in human trial, 62 subjects diagnosed as overactive bladder will be enrolled and treated with cinnamon patch. after treatment we will estimate the efficacy and record adverse events to conduct statistically analysis.

overactive bladder is a clinical syndrome characterized by frequency, with or without urge incontinence, urgency, and nocturia, which affect patients' sleeping quality and rehabilitation program progressing. current treatments include behavioral therapy (eg, life style adjustment, bladder training, pelvic floor muscle therapy) and medication. antimuscarinic agents is the most common medications prescribed for oab, but patients often have side effects like dry mouth and constipation. and there were plenty of herbal medicine which are beneficial to urine frequency and voiding dysfunction in ancient chinese medicine books and records. in human trial, 62 subjects diagnosed as overactive bladder will be enrolled and treated with cinnamon patch. after treatment we will estimate the efficacy and record adverse events to conduct statistically analysis. the 1st year project: (1) expect to enroll 62 clinical subjects of oab. (2) evaluate subjects 'symptom and proceed patch treatment. (3) record treatment responses including adverse effect. (4) conduct statistically analysis. the 2nd year project: (1) completing enrollment of 62 clinical subjects of oab. (2) finish evaluation and treatment of all subjects. (3) statistically analysis all collecting data (4) discuss and analyze the outcome.

Eligibility criteria:
inclusion criteria: * urgency score of oabss ≥ 2 or total score of oabss ≥ 3 exclusion criteria: * suffering from acute urinary tract infection * recurrent urinary tract infection ≥ 5 times in the last year * hematuria or bladder stone disease * using foley catheter * pregnant or breastfeeding women * spinal cord injury patients * mental illness or substance abuse * taking medicine for the treatment of overactive bladder within one month
rituximab, lenalidomide combined with methotrexate and temozolomide for primary central nervous system lymphoma

Conditions: Primary Central Nervous System Lymphoma

Summary: this is a prospective single arm, multi-center, phase ii clinical trial to observe the efficacy and safety of rituximab, lenalidomide combined with high-dose methotrexate and temozolomide (rl-mt) in the first-line treatment for patients with primary central nervous system lymphoma.


Eligibility criteria:
inclusion criteria: 1. age between 18 to 70 years old (including 18 and 70) 2. diagnosed as primary central nervous system lymphoma (limited to the brain, spinal cord, meninges and eyeballs, without involvement of other parts) 3. having not received anti-tumor therapy before enrollment (except for tumor resection and biopsy and the use of glucocorticoids to reduce central nervous system symptoms) 4. having at least one measurable lesions 5. world health organization-eastern cooperative oncology group performance status (ecog) 0-2 ( ecog 3 due to tumors can be included after being fully assessed by the investigator) 6. life expectancy no less than 1 month 7. enough main organ function 8. pregnancy test within 7 days must be negative for women of childbearing period, and appropriate measures should be taken for contraception for women in childbearing period during the study and six months after this study 9. agreeing to sign the written informed consents exclusion criteria: 1. diagnosed as secondary central nervous system lymphoma 2. diagnosed as cd20 negative large b cell primary central nervous system lymphoma 3. active malignant tumor need be treated at the same time 4. other malignant tumor history 5. serious surgery and trauma less than two weeks 6. patients with active tuberculosis 7. systemic therapy for serious acute/chronic infection 8. congestive heart failure, uncontrolled coronary heart disease, arrhythmia and heart infarction less than 6 months 9. hiv-positive, aids patients and untreated active hepatitis 10. patients with a history of deep vein thrombosis or pulmonary embolism less than 12 months 11. patients with a history of mental illness or drug abuse 12. poor compliance during the trial and/or follow-up phase 13. allergies or people who are known to be allergic to any active ingredients, excipients, mouse-derived products or heterologous protein contained in this trial 14. researchers determine unsuited to participate in this trial

Keywords: primary central nervous system lymphoma rl-mt
radioactive seed-guided resection of cholangiocellular carcinoma in cirrhotic patients

Conditions: Liver Cancer; Liver Cirrhosis

Summary: detection of cholangiocellular and hepatocellular carcinomas can be challenging in both radiologic imaging and during surgical resection. therefore, radioactive seed-guided resection of these tumors, analogously to breast cancer, could be an interesting approach. the investigators present two cases of cirrhotic patients where this method of tumor labelling was used.

the investigators selected two cases of patients with liver cirrhosis where seed-guided liver resection was used. seed-guided resection is procedure that is usually commonly used in breast cancer surgery but so far not in liver surgery. this report emphasizes the difficulties, which surgeons and radiologists may face in tumor entities that are difficult to identify both macroscopically, by palpation and intraoperative imaging techniques. the first case was a patient suffering from suspected hepatocellular carcinoma with the background of alcoholic liver cirrhosis. this patient already underwent liver surgery to remove the suspected tumour but the lesion could not be removed correctly as identification was not possible neither with palpation nor with the help of intraoperative ultrasound. for this reason, the patient was selected for seed-guided resection. the second patient, who presented nine months after the first one, presented with the suspicion of cirrhosis, two lesion small in size and in a surgically difficult localization. therefore, the patient was selected for seed-guided resection.

Eligibility criteria:
inclusion criteria: * suspect cancerous liver lesion * fit for surgery exclusion criteria: * emergency surgery * age under 18
bread in overweight/obesity treatment

Conditions: Overweight; Obesity

Summary: the purpose of this study is to determine the utility of an hypocaloric diet with or without bread in patients with overweight and obesity


Eligibility criteria:
inclusion criteria: * age \> 18 years * sex female * signed informed consent * patient with overweight and obesity (imc: \> 25 \< 39.9) exclusion criteria: * family and social environment that prevents compliance with treatment diet. * having to perform any kind of diet special sickness associated: celiac disease, chronic renal failure, etc. * patients with diabetes mellitus. * patients with eating disorders. * patients with dementia, mental illness or impaired function cognitive. * consuming drugs or substances for losing weight (except in those cases in which suspension thereof 15 days of beginning the study). * present disease which may interfere with weight loss: serious psychiatric disease, hypothyroidism not controlled. * be pregnant or period of lactation. * inability to comply with the physical activity plan agreed. * want to quit smoking during the time that lasts for the study.

Keywords: overweight obesity bread hypocaloric diet
ssnb in hemiplegic shoulder pain

Conditions: Shoulder Pain; Stroke

Summary: the purpose of this study is to compare suprascapular nerve block with therapeutic ultrasound in stroke patients who have shoulder pain in weak side.

shoulder pain is a common complication after a cerebrovascular accident.hemiplegic shoulder pain has been shown to affect stroke outcome in a negative way.it interferes with recovery after stroke:it can cause distress and reduced activities and can markedly hinder rehabilitation.suprascapular nerve block has been shown to be effective as an analgesic for different indications such as shoulder capsulitis.the purpose of this study was to evaluate the effectiveness of this technique conjunction with a rehabilitation program to reduce shoulder pain in hemiplegic patients.

Eligibility criteria:
inclusion criteria: * stroke patients who develope shoulder pain at weak limb. * good conscious and able to access pain score. * no history of drug reaction with xylocaine * no history of fracture,tumor or blood tendency. * willing to enrolled to study and signs inform consent. exclusion criteria: * patients who do not meet the inclusion criteria.

Keywords: suprascapular nerve block shoulder pain hemiplegia
a multicentre, retrospective study to evaluate the outcome of hsct mismatch unrelated donors

Conditions: Leukemia, Myeloid

Summary: the primary endpoint of the study was the acute gvhd incidence, the secondary endpoints were chronic gvhd incidence, overall survival (os), transplant related mortality (trm) incidence, relapse incidence (ri) and neutrophil and platelets engraftment after gvhd prophylaxis with atg-csa-mtx or ptcy-mmf-fk506


Eligibility criteria:
inclusion criteria: * children and adults) * hsct from a one-antigen mismatch unrelated donors * treated at the centro trapianti metropolitano di torino between 2012 to 2017 exclusion criteria: none