Kornimate/medical-research-clean huggingface dataset:
chemotherapy combined with adebrelimab and apatinib as the perioperative treatment in patients with biliary tract cancer

Conditions: Resectable Intrahepatic Cholangiocarcinoma With High Risk of Recurrence

Summary: this is a prospective, single-arm exploratory study to evaluate the efficacy and safety of chemotherapy combined with adebrelimab and apatinib as the perioperative treatment in patients with biliary tract cancer.


Eligibility criteria:
inclusion criteria: * confirmed intrahepatic cholangiocarcinoma * with resectable tumor lesion * no contraindications to surgery * with high risk of tumour recurrence * no prior systemic therapy for intrahepatic cholangiocarcinoma. * ecog performance status of 0 or 1 * child-pugh class: grade a exclusion criteria: * history of gastrointestinal hemorrhage within 6 months prior to the start of study treatment or clear tendency of gastrointestinal hemorrhage * abdominal fistula, gastrointestinal perforation or intraperitoneal abscess within 6 months prior to the start of study treatment * known genetic or acquired hemorrhage or thrombotic tendency * thrombosis or thromboembolic event within 6 months prior to the start of study treatment * cardiac clinical symptom or disease that is not well controlled * hypertension that can not be well controlled through antihypertensive drugs
comparison of the effect of spinal manipulation by gender

Conditions: Mechanical Low Back Pain; Chronic Pain; Gender; Neuromuscular Subluxation of Joint

Summary: the purpose of the study was to compare and evaluate the effects of spinal manipulation in patients with chronic mechanical low back pain by gender.

sixty-two participants with a diagnosis of mechanical low back pain participated in the research. 62 individuals were split into two groups based on gender. these were divided into male (n=31) and female (n=31) groups. for four weeks, spinal manipulation was applied twice a week to both groups. the world health organization quality of life assessment short form (whoqol-bref) was used to evaluate quality of life; the pittsburg sleep quality index (psqi) and mcgill pain questionnaire were used to evaluate sleep quality; visual analog scale (vas) was used to evaluate pain; oswetry disability index (odi) was used to evaluate pain-related disability; and a scale was used to evaluate the treatment quality. range of motion in the hips and lumbar region was measured with a goniometer.

Eligibility criteria:
inclusion criteria: * diagnosed with chronic mechanical low back pain * between the ages of 18 and 50 * read and speak turkish well enough to give informed consent and follow study instruction * being able to come for outpatient manipulation treatment * body mass index below 28 exclusion criteria: * currently involved in a legal proceeding related to back pain for which a workers' compensation claim is pending and have or have applied for permanent disability related to these problems * pregnancy * having any kind of malignancy * having any kind of osteoplastic disorders * having osteomyelitis, septic intervertebral discs and tb * history of a spinal fracture and stenosis * inflammatory low back pain * history of severe osteoporosis * history of any kind of bleeding disorders * taking steroids, anticoagulants, paracetamol, antidepressant drugs or drug-like substances * having any orthopedic and/or rheumatologic disease affecting the pelvic region * conservative or physical therapy for the lumbar region for the past 6 months

Keywords: mechanical low back pain spinal manipulation gender
amblyopia and strabismus detection using retinal birefringence imaging

Conditions: Amblyopia; Strabismus

Summary: the purpose of this project is to compare the accuracy of two products at detecting amblyopia and strabismus in children. the devices will be rebiscan's "blinq" (pediatric vision scanner; pvs) and rebiscan's rbi (retinal birefringence imager).

rebiscan is proposing a two-cohort study. the first cohort will include a population enriched for pathology in amblyopia to best assess device sensitivity, while a second cohort will be based in a primary care setting to best assess device specificity. the study will be conducted in busy, ethnically and economically diverse cites affiliated with the retina foundation of the southwest (rfsw) in greater dallas, tx area. each child will be screened with rebiscan's rbi device and it's pvs device in sequence, with results compared to the pvs as well as a comprehensive ophthalmic examination performed by a certified pediatric ophthalmologist in a statistically appropriate subset of screened subjects. testing times will be assessed to compare the efficiency of the pvs and the rbi screening experiences. the percentage of children successfully completing the screening process will also be measured. the rbi is expected to identify children with amblyopia and strabismus, without referring children who will not benefit from early treatment

Eligibility criteria:
inclusion criteria: * children who present to the participating clinics * provide assent * guardian provides informed consent exclusion criteria: - developmental delay or cognitive deficit
a proof-of-concept trial to study the safety and activity of linvoseltamab in participants with smoldering multiple myeloma at high risk of developing multiple myeloma

Conditions: Smoldering Multiple Myeloma (SMM)

Summary: this study is researching an investigational drug called linvoseltamab ("study drug") in participants at high risk of developing multiple myeloma (mm), a group commonly labeled as high-risk smoldering multiple myeloma (hr-smm). the aim of the study is to understand the safety and tolerability (how your body reacts to linvoseltamab) as well as the effectiveness (how well linvoseltamab eliminates plasma cells and prevents the development of mm) of the study drug. there are 2 parts to the study. * in part 1, linvoseltamab will be given to a small number of participants to study the early side effects (safety) of the study drug and make sure the treatment is acceptable. * in part 2, linvoseltamab will be given to more participants to continue to assess the side effects of the study drug and to evaluate the ability of linvoseltamab to treat hr-smm and prevent progression to mm. the study is looking at several other research questions, including: * how many participants treated with linvoseltamab (study drug) have improvement of their hr-smm? * what side effects may happen from taking the study drug? * how much study drug is in your blood at different times? * whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)


Eligibility criteria:
key inclusion criteria: 1. high-risk smm diagnosis within 5 years of study enrollment 2. eastern cooperative oncology group (ecog) performance status ≤1 3. adequate hematologic and hepatic function, as described in the protocol 4. estimated glomerular filtration rate ≥30 ml/min/1.73 m\^2 key exclusion criteria: 1. evidence of myeloma defining events \*slim crab, as described in the protocol \*slim (greater than or equal to sixty percent clonal plasma cells in the bone marrow, involved/uninvolved free light chain ratio of ≥100 with the involved free light chain (flc) being ≥100 mg/l, mri with \>1 focal lesion) crab (hypercalcemia, renal insufficiency, anemia, or lytic bone lesions) 2. diagnosis of systemic light chain amyloidosis, waldenström macroglobulinemia (lymphoplasmacytic lymphoma), soft tissue plasmacytoma, or symptomatic multiple myeloma 3. clinically significant cardiac or vascular disease within 3 months of study enrollment, as described in the protocol 4. any infection requiring hospitalization or treatment with iv anti-infectives within 28 days of first dose of study drug 5. uncontrolled human immunodeficiency virus (hiv), hepatitis b virus (hbv), or hepatitis c virus (hcv) infection; or other uncontrolled infection or unexplained signs of infection 6. history of severe allergic reaction attributed to compounds with a similar chemical or biologic composition as the study drug or excipient note: other protocol defined inclusion/exclusion criteria apply

Keywords: linvoseltamab multiple myeloma (mm) b cell maturation antigen (bcma) bispecific antibody
association between fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in parkinson's disease

Conditions: Parkinson Disease; Deep Brain Stimulation; Postoperative Delirium

Summary: postoperative delirium (pod) remains one of the most common neuropsychiatric complications after deep brain stimulation (dbs) surgery. the fibrinogen-to-albumin ratio (far) has been shown to significantly correlate with prognosis of many diseases associated with inflammation, but the relationship between far and pod is unclear. the investigators aimed to investigate the association between pod and far in parkinson's disease (pd) patients receiving dbs surgery. for this aim, the present study was conducted to provide a new method for the early recognition and perioperative management of delirium after dbs surgery in pd patients.


Eligibility criteria:
inclusion criteria: * over 55 years old * american society of anesthesiologists (asa) physical status i-iii * bilateral subthalamic nucleus deep brain stimulation surgery exclusion criteria: * preoperative delirium * missing preoperative laboratory parameters on fibrinogen or albumin * persistent infectious diseases * coagulopathy and autoimmune-illness or malignancies

Keywords: postoperative delirium fibrinogen-to-albumin ratio
clinical evaluation of the scopio cell morphology technology

Conditions: Blood Cancer

Summary: digital morphology is currently expanding and developing new applications based on artificial intelligence software. we recently published a study comparing screen validation and microscopic reading of bone marrow aspirates. the aim of the current research will be the comparison between optical microscope reading and automatic pre-classification (ai based)


Eligibility criteria:
inclusion criteria: * patients suffering from hemopathies with bone marrow aspirate assessable under the optical microscope exclusion criteria: * patients not affected by blood disorders * patients suffering from hemopathies with bone marrow aspirate that cannot be assessed under the optical microscope
the effect of brimonidine on intraocular pressure when dilating routine patients

Conditions: Intraocular Pressure

Summary: this an interventional study looking at two different sequences of pre-operative eye drops, to determine which order is more effective in reducing intraocular pressure with pupil dilation.

twenty healthy participants will be separated into two groups of 10 volunteers each. in both groups, the participant's right eye will serve as a control with only tropicamide/phenylephrine given. in one group of 10 participants the left eyes will receive alphagan prior to tropicamide/phenylephrine. in the other group of 10 eyes, the left eyes will have tropicamide/phenylephrine administered prior to alphagan. the investigator will observe the intraocular benefits of the addition of alphagan over the tropicamide/phenylephrine alone and determine if pre-treating is any better than post-treating. in addition, the investigator will monitor pupil response, as it is known that alphagan may have some effect on the pupil dilation.

Eligibility criteria:
inclusion criteria: * healthy with no major medical conditions. contact lens wear is ok but must be not worn on the day of the study exclusion criteria: * diabetic, history of glaucoma * history of iris trauma * history of eye surgery except lasik or photorefractive keratectomy laser eye surgery * anisocoria * pregnancy

Keywords: mydriasis cycloplegics
effectiveness of caudal epidural block on intraoperative blood loss during hypospadias repair

Conditions: Hypospadias

Summary: from september 2014 to march 2015, 57 consecutive patients with hypospadias who are candidate for surgery will be enrolled in this randomized clinical trial. regional ethics committee of isfahan university of medical sciences approved the protocol of the study and all parents will sign a written informed consent. inclusion criteria are age between 6 months to 15 years and hypospadias with any severity. exclusion criteria are coagulopathy, history of previous failed surgery, skin infection , parents' disagreement with the protocol and any cardiac problem that made epinephrine injection contraindicated. all selected patients will randomly allocate to one of the two groups: group a will receive caudal epidural block (ceb) plus general anesthesia before surgery and group b will receive general anesthesia before surgery and ceb afterwards. the surgical procedures will be performed by a single pediatric urologist (fa). the surgical technique will be tubularized incised plate in all cases. intraoperative blood loss will be determined by weighing all surgical gauzes used during procedure with a digital scale measure to the nearest 0.01 gram, every 10 minutes to minimize the effect of water vaporization on gauzes weights. in addition to blood loss, operation time, dose of fentanyl used during procedure and length of the urethral plate defect will be recorded for each patient by trained nurses. demographics and disease characteristics as well as operation details will be compared in the two studied groups.


Eligibility criteria:
inclusion criteria: age between 6 months to 15 years and hypospadias with any severity exclusion criteria: coagulopathy, history of previous failed surgery, skin infection , parents' disagreement with the protocol and any cardiac problem that made epinephrine injection contraindicated
effect of mobile phone telemedicine on diabetes care

Conditions: Diabetes Mellitus

Summary: adult patients with diabetes on insulin are eligible for the study. they will be randomized to a group using standard of care communication and a group using an i phone intervention.

type 1 or type 2 diabetes mellitus subjects who know how to operate and own an iphone, are between the age of 19 to 75, and are on a basal/bolus insulin regimen will be included in the study. subjects will be randomized to two groups - iphone versus standard of care and seen in our clinic at an initial/baseline and three month clinical visit. the control group will e-mail, fax, or call their blood glucose log results once a month for an insulin regimen adjustment through verbal communication with a certified diabetic educator once a month as is already implemented at the diabetes center. this group will be compared to the intervention group who will submit their blood glucose log results through an iphone mobile application, called diabetes doctor, once a month for an insulin regimen adjustment by a physician with a text message response. the two groups will have their hba1c, hypoglycemic events, blood glucose dispersion compliance, quality of life, usability and satisfaction with the use of a mobile application will be assessed at each visit with surveys.

Eligibility criteria:
inclusion criteria: * type 1 or type 2 diabetes mellitus on insulin basal/bolus injection * own and are able to operate an iphone exclusion criteria: * type 2 diabetics using only oral medications * do not own or know how to operate an iphone
a safety and efficacy study of relamorelin in diabetic gastroparesis 01

Conditions: Gastroparesis; Diabetes Mellitus

Summary: this study will evaluate the safety and efficacy of relamorelin compared to placebo in participants with diabetic gastroparesis. participants will report daily severity scores of their diabetic gastroparesis symptoms.


Eligibility criteria:
inclusion criteria: * diagnosis of type 1 or type 2 diabetes mellitus * meet the per protocol criteria of diabetic gastroparesis * compliance with diary * compliance with the per protocol study treatment dosing instructions exclusion criteria: * currently receiving nutrition intravenously, by nasogastric tube, or other feeding tube * actively experiencing anorexia nervosa, binge-eating, bulimia, or other eating disorder at the time of screening (visit 1) * diagnosis of celiac disease, also a history of non-celiac gluten sensitivity * history of gastrointestinal disorders that may be similar to gastroparesis * functional dyspepsia diagnosed before the diagnosis of diabetes mellitus
sublingual misoprostol versus standard surgical care for the treatment of incomplete abortion in nigeria

Conditions: Incomplete Abortion

Summary: women diagnosed with incomplete abortion in this health facility will be randomized to receive one of the following regimens: 400 mcg sublingual misoprostol in one dose or standard surgical treatment (mva). the investigators hypothesize that treatment of incomplete abortion with misoprostol using 400 mcg administered sublingually will be as effective as surgical evacuation.


Eligibility criteria:
inclusion criteria: * no contraindications to misoprostol * uterine size was not larger than 12 weeks * there were no signs of severe infection * haemodynamically stable * in general good health * willing to provide contact information exclusion criteria: * an iud in place * ectopic pregnancy * aged below 18 years and had no accompanying adult to provide informed consent
the safety and efficacy of addition of gentamicin on irrigation fluid in prevention of post-transurethral resection of the prostate infectious complications.

Conditions: Post-TURP Infectious Complications

Summary: the aim of this clinical study is to evaluate the safety and efficacy of addition of gentamicin on irrigation fluid during trans-urethral resection of the prostate (turp) and its role in reduction of post-turp infectious complications. the participants will be randomly divided into two groups: group a (gentamicin group) and group b (placebo).

220 patients scheduled for turp for the management of urinary retention or luts will be included and divided into two groups; "group a" includes 110 patients who will undergo turp with addition of one ampoule of gentamicin 80 mg (2ml) /3l of irrigation solution (the first 9 liters during resection and the first 6 liters during post-operative irrigation) and "group b" includes 110 patients who will undergo turp with addition of normal saline (2 ml) as a placebo on the irrigation solution. determination of gentamicin in human serum using hplc/uv after chemical derivatization will be done using the method of barends et al (barends, brouwers, \& hulshoff, 1987). both groups will be compared as regards the demographic data, post-operative pyuria and bacteruria (1 week after removal of urethral catheter), fever, and/or sepsis.

Eligibility criteria:
inclusion criteria: * adult patients with enlarged prostate presenting with luts or urine retention exclusion criteria: * unfit patients * renal impairment * active uti * urethral strictures
sex differences in neuropeptide y serum, but not in fat intake and body mass index

Conditions: Nutrient Deficiency

Summary: one's appetite has a role in controlling food intake and maintaining energy balance, but its effect on body metabolism related to obesity is still questionable. the purpose of this study was to determine the levels of neuropeptide y in healthy people and to see differences in gender and anthropometric parameters. the hypothesis of this study was that there would be differences in neuropeptide y levels in groups with gender and anthropometric parameter differences.

one's appetite has a role in controlling food intake and maintaining energy balance, but its effect on body metabolism related to obesity is still questionable. the purpose of this study was to determine the levels of neuropeptide y in healthy people and to see differences in gender and anthropometric parameters. the hypothesis of this study was that there would be differences in neuropeptide y levels in groups with gender and anthropometric parameter differences. this study was a cross-sectional study involving 62 study subjects, male and female, who did not have chronic diseases or metabolic disorders. this research was conducted from april to september 2020. the parameters examined in this study were neuropeptide y levels and anthropometric parameters. the statistical analysis performed was the mann-whitney test to see the differences between groups. the mean age of the research subjects was 40.48 ± 10.85 years, with the same ethnic distribution. the distribution of men and women was more women than men. based on anthropometric examination, it was found that obesity nutritional status was more common in the female group than in the male group; however, serum neuropeptide y levels were found to be significantly different between male and female groups (male group was higher).

Eligibility criteria:
inclusion criteria: * healthy groups for neuropeptide y serum diagnosis exclusion criteria: * non-healthy groups for neuropeptide y serum diagnosis

Keywords: obesity appetite neuropeptide orexigenic energy gender
improving outcomes in pics with home-based program of rehabilitation and health coaching

Conditions: Post-Intensive Care Syndrome

Summary: the purpose of this study is to gather information on the effectiveness of a home-based rehabilitation program that also includes health coaching in patients who may suffer from post-intensive care syndrome (pics). many patients who are admitted to a hospital icu suffer from new or worsening symptoms related to their medical condition and icu care. these new or worsening symptoms may persist for some time and are collectively called post-intensive care syndrome (pics).


Eligibility criteria:
inclusion criteria: * adults (age ≥ 18) with pics defined as admitted to the icu for more than 48 hours with any of the following conditions: respiratory failure of any cause requiring mechanical ventilation ≥ three days, any shock requiring vasopressors and/or inotropes, development of delirium during the icu stay, , and cardiac arrest during the index hospital admission. * a habc-m-sr score \> 12 points. exclusion criteria: * any mechanical ventilation in the last two months before the index icu admission * ≥ 5 days in the icu over the previous month before the index icu admission * receiving hospice or palliative care * severe uncontrolled psychological or psychiatric disorders, e.g., schizophrenia, bipolar disorder, struggling to cope as a result of their personality disorder, uncontrolled substance abuse (alcoholism, illegal drugs) homelessness would make them unsuitable for the intervention * a co-morbidity so severe it would prevent the patient from engaging fully in the intervention/ control, e.g., progressive cancer, anoxic brain injury, severe rheumatoid arthritis or osteoarthritis, multiple sclerosis, chronic widespread pain syndrome, previous cerebral vascular event that the patient would not be able to participate in pr * patients with moderate/severe cognitive impairment per medical records screening * inability to obtain informed consent.