Kornimate/medical-research-clean huggingface dataset:
virtual reality in burn pain management

Conditions: Burns; Pain

Summary: to examine the safety and efficacy of virtual reality (vr) distraction therapy in burn patients experiencing severe procedural pain during wound care.

this is a prospective, randomized cross-over study of the safety and effectiveness of the use of a virtual reality distraction intervention to management procedural pain during burn wound care. up to 20 subjects will be enrolled until 12 complete the study.

Eligibility criteria:
inclusion criteria: * 18 years or oler with thermal injury * understands english * patient perception of previous wound care procedural pain is greater than 6 on a numeric pain scal of 0-10 where 0= no pain and 10=worst pain ever experienced * ability to use a computer mouse or hit the space bar on a computer keyboard exclusion criteria: * unhealed burned wounds on face, neck or head * history of severe susceptibility to motion sickness * presence of open woun ds to the hands that cannot be covered with a dressing while operating the control button * patients who report a feeling of anxiety or discomfort while viewing the snow world software on a computer without the helmet

Keywords: wound care
effect of vitamin d supplementation on mental health: an exploratory study on a university students suffering from vitamin d deficiency

Conditions: Psychiatric Disorder

Summary: university students are susceptible to psychological burdens such as depressive symptoms, anxiety, and stress which might have been linked to vitamin d deficiency. low serum vitamin d level is well recognized around the world. vitamin d has been reported to modulate several neurological pathways in the brain that control psychological function. as a result, the purpose of this study is to evaluate the effect of vitamin d supplementation on the presence of depressive symptoms, anxiety, and stress in university students. the study will include two phases. the first phase is a cross-sectional phase assessing the prevalence vitamin d deficiency in addition to psychological symptoms. the second phase is a randomized controlled clinical trial that aims to assess the effect of vitamin d supplementation on the prevalent psychological symptoms and its impact on the academic performance among university students. the study will look at the relationship between mental health and vitamin d deficiency, as well as how it will affect academic performance of university students.


Eligibility criteria:
inclusion criteria: * for phase 1: sample will be selected using convenient sampling method where all students with an age range 18-22 years old fulfilling the eligibility criteria will be educated about the study protocol and will be asked to participate in the study. for phase 2: students who diagnosed with deficient vitamin d level will be asked to participate in the study. exclusion criteria: * hypersensitivity to oral vitamin d supplements such as diviton or vidrop. * students taking medications affecting vitamin d metabolism such as anti-seizure medications: phenytoin, phenobarbital and carbamazepine, isotretinoin, steroids: dexamethasone, antibiotics: isoniazid and rifampin and antifungals: clotrimazole. * students taking antidepressants, drug for bipolar disorder treatment like lithium and antipsychotic agents like olanzapine. * students with insufficient vitamin d level (20-30 ng/ml). * students with confirmed diagnosis with psychiatric illness. * students with a history of liver disease or dysfunction. * students with a history of kidney disease or dysfunction.
determining developmental and clinical markers affecting urinary function of children with spinal dysraphism

Conditions: Spinal Dysraphism

Summary: to identify developmental and clinical biomarkers that affect urinary incontinence at the ages of 5, 7, and 10 according to different neuro-urological clinical factors.

this retrospective observational cohort study aims to identify developmental and clinical biomarkers that affect urinary incontinence at the ages of 5, 7, and 10 according to the types of spinal dysraphism, conus medullaris location, and urodynamics test results.

Eligibility criteria:
inclusion criteria: - those who received spinal dysraphism diagnosis (icd code: q05.1-05.9) and have been following up and receiving treatments due to neurogenic bladder. exclusion criteria: - as the study is a retrospective study, there is no exclusion criteria.

Keywords: spina bifida neurogenic bladder neurogenic detrusor overactivity detrusor overactivity incontinence
study evaluating antibiotic use in reducing vancomycin-resistant enterococci and esbl producing escherichia coli and klebsiella pneumoniae in intensive care

Conditions: Escherichia Coli Infections; Klebsiella Infections

Summary: to determine whether the restriction of 3rd generation cephalosporins and carbapenems contribute to the reduction of intestinal colonization or infection with vancomycin-resistant enterococci (vre) in a medical intensive care unit (micu).


Eligibility criteria:
inclusion criteria: * all patients admitted to or transferred to the micu. * patients 18 years of age or older. * provide written informed consent. exclusion criteria: * patients known to be infected or colonized by vre or esbl-producing e.coli, k.pneumoniae. * patients who have hypersensitivity to penicillin. * any underlying conditions or diseases that will be ultimately fatal within 48 hours. * any concurrent condition or medication which would interfere with absorption or metabolism of study drugs.

Keywords: bacterial infections
optimizing recovery in trauma patients by integrating enhanced nutrition delivery

Conditions: Trauma; Critical Illness

Summary: this is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients. subjects will be randomized 1:1 to either enhanced nutrition or control arm. subjects randomized to the enhanced nutrition arm will receive oral nutrition supplements (ons) up to 3 times per day while in the hospital and for 4 weeks after discharge. subjects in the standard of care arm will receive normal nutrition recommendations from their clinical providers. participants in both groups will undergo non-invasive tests that measure how much energy (calories) they are using, body composition, and muscle mass.

this is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients. enhanced protein supplementation supports patients from icu admission to 4-weeks post-hospital discharge, providing a comprehensive and personalized plan of care carried to completion. subjects will be randomized 1:1 to enhanced nutrition or control arm. subjects randomized enhanced nutrition oral nutrition supplements (fresenius kcal shakes) up to 3 times per day while in the hospital and for 4 weeks after discharge. subjects in the standard of care arm will receive normal nutrition recommendations from their clinical providers. participants in both groups will undergo non-invasive tests that measure how much energy (calories) they are using, body composition, and muscle mass. they will also be asked to complete walking and strength tests, and surveys about quality of life.these will be done at hospital admission, day 14 or hospital discharge, and at a one month post-discharge follow-up visit.

Eligibility criteria:
inclusion criteria: * patients who are at least 45 years old and presented to the emergency department as a leveled trauma * patients who have the ability to tolerate oral nutrition * patients who have had a standard of care ct scan this admission exclusion criteria: * expected withdrawal of life-sustaining treatment within 48 hours * traumatic brain injury * presence of lower extremity fracture(s) * mechanical ventilation * subjects for who the investigator would recommend a different supplement based on their medical condition. * prisoner * pregnancy for women of child-bearing potential
evaluation of different interfaces for noninvasive positive pressure ventilation (nppv)

Conditions: Respiratory Failure; Healthy

Summary: in this study the investigators aimed to study the ventilatory performance of different interfaces during nppv delivering.

we will test the ventilatory performance in term of ventilatory pattern, muscle effort and gas exchange of different interfaces for nppv.

Eligibility criteria:
inclusion criteria: * adult healthy subjects exclusion criteria: * barotrauma
predictors of diabetic foot outcome in chronic kidney disease patients

Conditions: Diabetic Foot Disease; Chronic Kidney Disease Due to Type 2 Diabetes Mellitus

Summary: individuals with diabetic neuropathy and chronic kidney disease (ckd) are 15 times more likely to have a non-traumatic lower extremity amputation compared to those with dm alone . the incidence of df and its evolution appear to be proportionally related to the stage of ckd . one of the most important causes is vascular calcification, which is common in patients with atherosclerosis, dm, ckd, and elderly . various factors, including age, gender, infection severity, local ischemia, diabetes duration, neuropathy, and blood sugar control, are considered potential predictors for df outcome. however, there remains a lack of complete this study aim to assessment of predictors of diabetic foot development and outcome in chronic kidney disease patients.

about 537 million adults are living with diabetes mellitus (dm). this number is predicted to rise to 643 million by 2030 . diabetic foot (df), being one of the most prevalent, severe, and costly complications of dm. it is primarily characterized by skin infections, ulcers, or destruction of deep tissues below the ankle joint. it is commonly associated with neuropathy or vascular disorders in the lower extremities, and in severe cases, it may involve muscles and bones . ultimately, 19% to 34% of patients with diabetes will suffer from df during their lifetimes . around 20% of df patients may require lower limb amputations, which can be either minor (below the ankle joint) or major (above the ankle joint), and sometimes both . individuals with diabetic neuropathy and chronic kidney disease (ckd) are 15 times more likely to have a non-traumatic lower extremity amputation compared to those with dm alone . the incidence of df and its evolution appear to be proportionally related to the stage of ckd . one of the most important causes is vascular calcification, which is common in patients with atherosclerosis, dm, ckd, and elderly . various factors, including age, gender, infection severity, local ischemia, diabetes duration, neuropathy, and blood sugar control, are considered potential predictors for df outcome. however, there remains a lack of complete understanding regarding the most significant factors and their respective impact on the outcome .

Eligibility criteria:
inclusion criteria: * - age ≥18 years old. * type 2 dm with or without df . * patients are at different stages of ckd as defined according to kdigo (9). exclusion criteria: * - patients on dialysis or ckd stage 5 (gfr \< 15 ml/min) * patients with kidney transplant * pregnant patients * type 1 dm

Keywords: chronic kidney disease
parental anxiety and postoperative pain and complications in children undergoing tonsillectomy ± adenoidectomy

Conditions: Parents; Anxiety; Complication of Surgical Procedure; Pain

Summary: it is aimed to understand whether high parental anxiety leads to increased pain in children undergoing tonsillectomy ± adenoidectomy surgery and whether it increases the development of complications.


Eligibility criteria:
inclusion criteria: * 4-15 years old child patient * willingness to participate in the study by the patient and/or parent * no history of psychiatric-mental illness or drug use in the patient and/or parents * the patient has no craniofacial anomaly, genetic disorder, cleft palate-lip anomaly * no bleeding disorder or disease exclusion criteria: * \ 15 years old paediatric patients * not wanting to participate in the study at any stage of the study * history of psychiatric-mental illness or drug use in the patient and parents * the patient has craniofacial anomaly, genetic disorder, cleft palate-lip anomaly * having a bleeding disorder or disease

Keywords: parental anxiety tonsillectomy postoperative pain complication of tonsillectomy
coronary heart disease risk in type 2 diabetes

Conditions: Coronary Heart Disease; Type 2 Diabetes

Summary: the primary objective of the cordia study is to use an effective evidence-based self-management intervention (smi) for type 2 diabetes, with and without a novel test to give a personalised genetic and lifestyle risk of coronary heart disease, to examine their capacity to reduce the risk of coronary heart disease (chd) and improve diabetes management in primary care patients with type 2 diabetes. the effect of these interventions on clinical, behavioural and psychological outcomes will be investigated.


Eligibility criteria:
inclusion criteria: * males and females aged 25-70 years diagnosed with type 2 diabetes * white, afro-caribbean or asian-indian ethnicity * most previous or baseline hba1c ≥6.5% or 48 mmol/mol * fluency in written and spoken english exclusion criteria: * diagnosis of ischemic heart disease, stroke, transient ischaemic attack (tia) or peripheral vascular disease * serious or enduring mental health problems that would prevent the patient from completing the study * currently receiving treatment for a life-threatening condition (e.g., cancer) or in the terminal stages of a condition * adults who cannot consent for themselves
evaluation of lung doppler signals in pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: the purpose of this study is to evaluate the lung doppler signals in patients with pulmonary hypertension that undergo (prospective arm) or underwent (retrospective arm) right heart catheterization (rhc) in order to assess whether this non-invasive tool could be used in pulmonary hypertension diagnosis and monitoring.

protocol summary title: evaluation of lung doppler signals (lds) in pulmonary hypertension (phtn) device: sonara/tek transcranial doppler (tcd) system study objectives: to evaluate the lds in patients with phtn that undergo (prospective arm) or underwent (retrospective arm) right heart catheterization (rhc) in order to assess whether these signals can be used in pulmonary hypertension diagnosis and monitoring. study design: two study arms: 1. prospective arm to measure lds during right heart catheterization in patients undergoing the procedure for evaluation of phtn. 2. retrospective arm to measure lds in patients in whom previous rhc confirmed the presence of phtn. recruitment target: prospective arm: 50 patients during 18 months. retrospective arm: 50 patients during 18 months. study population: 1. patients suspected of phtn by echocardiogram, who are scheduled to undergo rhc (prospective arm) 2. patients who underwent rhc in the past and were diagnosed with phtn (retrospective arm) study endpoint: 1. comparison of pulmonary blood pressures at rest, following vasodilator medication and following upper extremities exercise as measured by rhc and by the lds during the valsalva maneuver. 2. determining lds characteristics of phtn patients

Eligibility criteria:
inclusion criteria: 1. prospective arm: * man or woman aged over 18. * with suspicion or diagnosis of pulmonary hypertension. * scheduled to undergo right heart catheterization * able and willing to give informed consent. 2. retrospective arm: * man or woman aged over 18. * with diagnosis of pulmonary hypertension confirmed by right heart catheterization in the past. * able and willing to give informed consent. exclusion criteria: 1. both arms: * minor (aged \< 18). * people unable or unwilling to give informed consent. * hemodynamically unstable patients. * pregnant women. 2. prospective arm only: * patients with contra-indication to right heart catheterization. * patients incapable of performing a valsalva maneuver. * patients with recent myocardial infarction, high degree av block, severe aortic stenosis or glaucoma

Keywords: pulmonary hypertension doppler valsalva
long-term study of nateglinide+valsartan to prevent or delay type ii diabetes mellitus and cardiovascular complications

Conditions: Diabetes Mellitus, Type 2

Summary: this study is a test of the safety and effectiveness of two drugs, one for diabetes and one for hypertension, in keeping patients with high lab values of glucose from progressing to frank diabetes and developing cardiovascular complications. people in this study cannot have frank diabetes but are considered "borderline" based on blood tests. people in the study take none, one or both of the drugs and do not know which one(s) they are taking.


Eligibility criteria:
inclusion criteria: * adults * impaired glucose tolerance * age dependent risk factors exclusion criteria: * frank diabetes for detailed information, call contact person.

Keywords: prevention diabetes type 2 valsartan nateglinide
effects of gardemont s.a food supplement on upper respiratory illness

Conditions: Respiratory Infections

Summary: general:prospective, randomized, double blind controlled trial of the food supplement goldtrain plus, to assess its safety and efficacy in comparison to placebo in subjects with upper respiratory infection. hypothesis: the food supplement goldtrain plus will be superior to placebo in shortening the time to recovery from the disease symptoms. study design and outcome measures:study population of 182 generally healthy subjects with acute respiratory infection randomized in 1:1 ratio to active supplement versus placebo treatment, with randomization stratified by site. the study supplement administration will be continued for 7 days, and patient global assessment (pga) will be the main primary measurement tool, based on a self-reporting questionnaire filled and monitored every 12 hours for 7 consecutive days. throat and nasal swabs determining type of viral infection, will be taken at inclusion of patient and a number of blood tests at the end of treatment to look for any adverse effects of the medication. analysis and conclusion: all data-from the filled questionnaires, clinical follow up and laboratory studies will be analyzed by multivariate analysis to determine the efficacy of the supplement and its correlation to the clinical and laboratory parameters.


Eligibility criteria:
inclusion criteria: 1. signed informed consent 2. age eligible (18 ≤ age ≤ 90) 3. respiratory infection with or without fever- exclusion criteria: 1. evidence of the bacterial infection 2. symptoms suggestive of other than respiratory system illness (i.e. diarrhea, abdominal pain, skin rash, urinary symptoms). 3. hospitalisation is planned 4. surgery within previous 2 months 5. pregnancy (women at childbirth age should have a urine beta-hcg test performed) 6. subject with known renal dysfunction (creatinine ≥ 2 mg/dl) 7. subject has history of debilitating liver dysfunction with elevation of liver enzymes and bilirubin levels to ≥ uln 8. participation in the active follow-up phase of another clinical study of an investigational drug or device 9. known hypercalcemia -

Keywords: respiratory infection viral infection food supplement goldtrain plus (gt+)
a video intervention to decrease patient fear of colonoscopy after a positive fecal immunochemical test

Conditions: Colorectal Carcinoma

Summary: this clinical trial compares an educational video intervention versus usual care of no video intervention in decreasing patient fear of a colonoscopy procedure after receiving a positive fecal immunochemical test (fit). the lack of a follow-up colonoscopy after an abnormal fit result is associated with an increased risk of colorectal cancer mortality, advanced-stage colorectal cancer, among other complications, compared to the completion of a follow-up colonoscopy. an educational video may reduce patient fear and increase knowledge, self-efficacy, and intent to complete a colonoscopy compared to the usual care of no video intervention.

outline: patients are randomized to 1 of 2 arms. arm 1: patients watch an educational video about the importance of abnormal fit results, the implications if follow-up colonoscopy is not completed, and demonstrate the steps to complete a colonoscopy. arm 2: patients receive usual care and do not watch the educational video. after completion of study, patients are followed for 12 months after their abnormal fit result.

Eligibility criteria:
inclusion criteria: * age 45-75 * have an assigned primary care provider in our partnering safety-net health system * have a billable primary care encounter between 2019-2022 * have an abnormal fit result for colorectal cancer (crc) screening without a colonoscopy within 1 year * ability to communicate in english due to initial videos being available in english exclusion criteria: * adults \ age 75 * patients who receive care at other university of washington (uw) medicine sites (non-safety-net patients) * individuals without a primary care encounter between 2019-2022 * individuals whose primary language is not english
fractional resurfacing device for treatment of acne scarring

Conditions: Acne; Scar

Summary: the purpose of this research study is to evaluate the safety and effectiveness of a new investigational laser device for treatment of acne scarring, for improvement in the appearance of surface texture and topography (recessed or uneven surfaces).

thirty subjects between two research locations with an acne scar severity score greater than 4 will receive up to 3 treatments with an fda ide and institutional review board approved 10,600nm fractional carbon dioxide laser system. improvement of acne scarring is evaluated at 1 month and 3 months post-treatment. post-treatment responses evaluated are immediate erythema, immediate edema, and any other immediate responses. evaluations are conducted immediate post treatment and one week post-treatment. key safety data include the severity scoring of post-treatment responses, as well as by photodocumentation. the incidence of side effects such as scarring, pigmentary changes, etc. are evaluated at follow-up visits one and three months post-treatment. key safety data include the incidence rates and severity scoring of side effects, as well as by photodocumentation

Eligibility criteria:
inclusion criteria: * have fitzpatrick skin type i-v. (type i is blonde/red hair with freckles and type v are hispanics and lighter african americans.) * are male or female. * are between 18 and 75 years of age. * have moderate to severe acne scarring. acne scarring will be assessed with the acne scar severity scale. subjects will be eligible for treatment if the area to be treated is scored as having an acne scar severity score \> 4 according to the acne scar severity scale (0-9). * are able to read, understand, and sign the informed consent. * are willing and able to comply with all follow-up requirements for a minimum of 8 months. exclusion criteria: * have had active localized or systemic infections within 6 months of enrollment * have compromised ability for wound healing, such as: malnutrition, oral steroid use, history of collagen vascular disease (e.g. lupus, scleroderma, history of keloid formation (raised and thickened scars), atrophic dermatitis (extreme skin irritation or itchiness) or immunologic abnormalities such as vitiligo (white patches of skin due to loss of pigment) * have immunocompromised status (inability to resist infection, etc.) * have been treated with lasers, chemical procedures, or other cosmetic procedures on the area to be treated within 6 months of enrollment * have taken accutane within 12 months of enrollment * are allergic to lidocaine (skin numbing agent) * are allergic to valtrex (an anti-viral medication)

Keywords: acne vulgaris scarring laser