Kornimate/medical-research-clean huggingface dataset:
wellness and weight family group project

Conditions: Pediatric Obesity

Summary: the purpose of the current study is examine the feasibility and efficacy of providing a behavioral family intervention in 30 youth 10 to 17 years of age who are obese and attending a multidisciplinary pediatric obesity clinic and their parents. participating families will complete assessments consisting of weight status, dietary intake, physical activity, health-related quality of life, psychological functioning, home-food environment, parenting skills, and self-efficacy at pre-treatment (baseline), post-treatment (month 3), and 2 month post-treatment follow-up (month 5). family attendance data will be collected during the behavioral family intervention and children and parents will complete a treatment satisfaction questionnaire at the post-treatment assessment. health outcomes (e.g., a1c, glucose) routinely assessed through standard medical care in the multidisciplinary pediatric obesity clinic will be obtained from child medical charts.


Eligibility criteria:
inclusion criteria: 1. child 10 to 17 years of age attending an outpatient pediatric obesity clinic visit 2. child or adolescent is obese (equal to or above the 95th percentile for bmi based on centers for disease control and prevention (cdc) norms for age and gender) 3. child or adolescent is accompanied by a parent or legal guardian 4. participating child and parent speak and read english 5. family agrees to attend group meetings at a medical clinic over a 3 month period exclusion criteria: 1. participating child or parent, according to parent report, has dietary restriction or medical condition contraindicating mild energy restriction or moderate physical activity (e.g., musculoskeletal, heart, or respiratory condition, uncontrolled blood pressure or exercise induced asthma) 2. child diagnosed according to parent report with pervasive developmental delay (e.g., autistic disorder) 3. child or parent, according to parent report, in commercial weight loss program 4. child or parent currently prescribed medications to impact appetite or weight loss/gain, according to parent report 5. parent and child do not speak and read english
insulin dependent gestational diabetes mellitus: randomized trial of induction of labour at 38 and 40 weeks of gestation

Conditions: Gestational Diabetes Mellitus

Summary: to evaluate the impact of induction of labour at 38 weeks with the induction of labour at 40 weeks in women with insulin dependent gestational diabetes mellitus on maternal and fetal outcome.


Eligibility criteria:
inclusion criteria: * pregnant women with insulin dependent gestational diabetes mellitus exclusion criteria: * chronic inflammatory disease, * autoimmune disease, * pre-existing diabetes mellitus, * previous cesarean section, * multiple pregnancies
multiple ascending-dose study of xmab®27564 in patients with psoriasis or atopic dermatitis

Conditions: Psoriasis; Atopic Dermatitis

Summary: the purpose of this study is to evaluate the safety and tolerability of xmab27564 following multiple doses among participants with plaque psoriasis and atopic dermatitis.

this is a phase 1b, randomized, double-blind, placebo-controlled, multiple ascending dose (mad) study of xmab27564. it is planned to enroll approximately 48 adult patients with mild-to-severe plaque psoriasis and 80 adult patients with moderate-to-severe atopic dermatitis. all patients will receive a total of 4 doses of study drug or placebo, administered subcutaneously every 2 weeks. a one year, open-label extension is available to qualifying patients.

Eligibility criteria:
inclusion criteria: the main inclusion and exclusion criteria include, but are not limited to, the following: * have active mild-to-severe plaque psoriasis or moderate-to-severe atopic dermatitis according to study-specific criteria * weight between 40 to 150 kg, inclusive * no topical treatments for psoriasis or atopic dermatitis for 2 weeks before randomization * no phototherapy for psoriasis for 4 weeks before randomization * washout of oral treatments for psoriasis or atopic dermatitis for 4 weeks before randomization * washout of biologic treatments for psoriasis or atopic dermatitis for 12 weeks before randomization * stated willingness to comply with all study procedures (including skin biopsies) and availability for the duration of the study exclusion criteria: * patients with a history of active asthma within 5 years of screening, except those that have well controlled asthma symptoms at screening visit. * patients who have had any prior investigational treatment with il-2 therapies

Keywords: psoriasis plaque psoriasis atopic dermatitis eczema
centrifugation vs. multiple-pass hemofiltration of the residual cardiopulmonary bypass volume

Conditions: Coronary Artery Disease; Heart Valve Diseases

Summary: traditional cardiac surgery requires patient connection to the cardiopulmonary bypass (cpb) apparatus which takes over the function of the heart and lungs while the surgeon performs the necessary surgery. the residual blood left in the cpb equipment (1.5-2.0 l) is centrifuged and washed leaving only red blood cells (rbcs) suspended in a saline solution. the rbcs are reinfused into the patient as needed by the anesthesiologist. the main problem with this technique is that many of the important components of the blood such as plasma proteins and clotting factors are discarded through cell washing. this study will explore a novel method (multiple-pass hemofiltration) of processing the residual pump blood which will allow the patient to receive their own whole blood with minimum waste of important components. the newer method of processing the residual pump volume has also been termed off-line modified ultrafiltration (off-line muf) and is similar to the process that the kidneys use to filter the blood. it is hypothesized that multiple-pass hemofiltration of the residual cpb volume will reduce the occurrence of inflammatory responses, preserve plasma proteins, and decrease allogenic blood exposure and improve clinical outcomes as compared to centrifugation.

this study is being performed because the traditional method of recovery of the residual volume of blood from the cardiopulmonary bypass circuit involves centrifugation and washing of whole blood with a saline solution. this process is sufficient for the recovery of red blood cells however; it results in the discarding of other important components of the blood. the removal of white blood cells, plasma proteins and clotting factors may result in an increased risk of a adverse outcomes during the post-operative period. the new technique our team wants to investigate returns a greater proportion of the patients' whole blood for reinfusion. our study objectives are to compare the two techniques and determine which technique produces the safest most reliable method of blood processing to help the patient have a smooth, short, transfusion free post-operative period in the intensive care unit (icu).

Eligibility criteria:
inclusion criteria: * all males and females that will be receiving open heart surgery (coronary artery bypass grafts and / or valve repair/replacement) during the study period. exclusion criteria: * history of bleeding disorders * history inflammatory diseases rheumatoid arthritis
study of tcm syndrome of hepatocellular carcinoma and colorectal cancer based on system science

Conditions: Malignant Tumor of Small Intestine Metastatic to Liver

Summary: traditional chinese medicine (tcm) syndrome is a core foundation of disease knowledge, clinical diagnosis and treatment and curative effect evaluation in tcm. "same tcm syndrome for different diseases" and "same treatment for different diseases" is one of the characteristics of tcm syndrome differentiation and treatment. this study is the "tcm disease syndrome combination" research baced on principles and methods of system biology, which is through acquisition of primary hepatocellular carcinoma (hcc) and colorectal cancer patients with tcm syndrome information, detection of clinical indicators and genomic, proteomic, and metabolites changes, analyzing the correlation between tcm syndromes and biological information, and revealing its biological material characteristics and the molecular mechanisms of "same tcm syndrome for different diseases";developing and implementing the program of tcm syndrome differentiation and treatment for hcc and colorectal cancer to evaluate the efficacy of tcm syndrome based-treatment of hcc and colorectal cancer with tcm syndrom scores, clinical and systems biological indicators, quality of life and survival rate, and to revealing the mechanism of the "same treatment for different diseases".

traditional chinese medicine (tcm) syndrome is a core foundation of disease knowledge, clinical diagnosis and treatment and curative effect evaluation in tcm. "same tcm syndrome for different diseases" and "same treatment for different diseases" is one of the characteristics of tcm syndrome differentiation and treatment. in this study, the investigators adopted the transcriptome analysis, proteome analysis and metabolic diversity analysis of the patients with different syndromes of liver cancer and colorectal cancer, and integrate omics information, combining macro and micro methods to screen biomarkers of syndromes

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of primary liver cancer (hcc) and colorectal cancer after surgery. 2. liver cancer and colorectal cancer liver and kidney yin deficiency and spleen qi deficiency syndrome diagnosis standard : yin deficiency of liver and kidney and spleen qi deficiency syndrome see hypochondriac pain, waist and knee limp, fever, night sweats, dry mouth and throat, fatigue, anorexia, abdominal distension after eating more, red or pale tongue, less moss or light peel, pulse fine. exclusion criteria: (1) there is a serious heart, kidney, and other diseases of the hematopoietic system effect of drug evaluation factors; (2)mental disorders (3)digestive tract obstruction; (4) poor compliance.
tia scores' mortality predictions and recurrent tia and stroke prediction

Conditions: Stroke, Ischemic; Transient Ischemic Attack

Summary: our study adopts a prospective design. our research aims to determine the significance of abcd2, abcd3-i, canadian tia score, and nihss score in predicting the likelihood of ischemic stroke within 30 days in patients presenting to the emergency department with transient ischemic attack (tia)

our study is planned as follows: patients diagnosed with transient ischemic attack (tia) presenting to the emergency department will undergo scoring by researchers, although they will not intervene the treatment process of the patients. patients will be contacted by researchers or their families to ascertain whether they experience a recurrent stroke or tia within 30 days, and their current health status will be assessed. the collected information will be recorded. the study will include patients diagnosed with transient ischemic attack (tia) based on tests and imaging conducted at ankara etlik city hospital's emergency department. the planned duration for data collection and analysis is one year. parameters to be examined: age gender physical examination findings comorbidities (hypertension, coronary artery disease, valvular heart disease, copd, asthma, diabetes, others) neurological examination findings time of symptom onset admission status (intensive care unit / ward) findings from ultrasound, computed tomography, and mri imaging length of hospital stay mortality (yes/no) we aim to collect data from approximately 300 patients within the course of one year for our study

Eligibility criteria:
inclusion criteria: patients presenting to the emergency department and diagnosed with tia patients diagnosed with ischemic stroke who did not receive thrombolytic therapy based on nihss score patients aged 18 and above patients who consented by signing the informed consent form exclusion criteria: patients diagnosed with hemorrhagic stroke patients unwilling to participate in the study patients with a history of trauma patients unable to receive thrombolytic therapy for any reason (trauma, malignancy, etc.) patients under the age of 18 patients transferred from another hospital patients who experienced cardiac arrest patients who died for any reason other than ischemic stroke within 30 days patients wishing to withdraw from the study at any time during the study period

Keywords: transient ischemic attack ischemic stroke tia scores
prevention of nosocomial bacteremia among zambian neonates

Conditions: Neonatal Sepsis; Neonatal Mortality

Summary: the purpose of this study is to estimate the burden of disease, identify risk factors associated with nosocomial bacteremia among neonates and assess the efficacy of low-cost measures targeted to known and suspected nosocomial bsi (bloodstream) risk factors, the investigators propose to study the impact of a novel package of infection control interventions on nosocomial bacteremia and mortality among neonates at a tertiary care center in sub-saharan africa.

the study is an18 month prospective quasi-experimental evaluation of nosocomial bacteremia and mortality among hospitalized neonates and will consist of a 6-month baseline period to capture the incidence and all-cause mortality of nosocomial bsis, a 1-month implementation period of low-cost infection control strategies (including alcohol-based hand rub \[ahr\], 2% chlorhexidine gluconate \[chg\], hospital staff education and text message-based reminders of infection control recommendation) and an 11-month intervention period. all neonates admitted to the neonatal intensive care unit (nicu) of the university teaching hospital (uth) in lusaka, zambia during the study period will be eligible for study enrollment. this study will determine the capacity of an innovative bundle of low cost, simple and locally available interventions that leverage new technologies and expand application of highly effective interventions in order to reduce the incidence of nosocomial bacteremia among nicu patients in a developing country setting.

Eligibility criteria:
inclusion criteria: * neonates admitted to the study site nicu during the study period (including both "inborn" and "outborn" neonates) exclusion criteria: * neonates without documented birth date * parent or guardian unavailable or unwilling to provide consent
safety study for adolescents with concussion

Conditions: Brain Injury; Concussion

Summary: the purpose of the study was to determine if administration of an exercise stress test within the first ten days after a sports related concussion would delay or otherwise interfere with recovery.

the purpose of the study was to determine if administration of an exercise stress test within the first ten days after a sports related concussion would delay or otherwise interfere with recovery. all participants were adolescents injured while playing sports. all concussions were confirmed by an experienced sports medicine physician before random assignment of the participant to receive the treadmill test to determine exercise intolerance or not. recovery was defined as (a) return to asymptomatic state; (b) ability to exercise to exhaustion without exacerbation of symptoms and (c) confirmation of recovery by a physician who is blinded to the assignment and to results of exercise testing. symptoms were self reported on a daily basis using an online data record. regardless of recovery rate all participants were assessed at two weeks following their first clinic visit. at the second visit all subjects, regardless of group assignment were assessed on impact, and the treadmill based exercise stress test. individuals who were not recovered by the second visit were followed until recovered no matter how long that took. analysis of data examined recovery rates of the two groups of adolescents to determine whether use of a exercise stress test early after concussion caused any adverse events or interfered in any way with recovery.

Eligibility criteria:
inclusion criteria: * adolescents with sports related concussion that appear for their first clinic visit within 10 days of injury exclusion criteria: * evidence of focal neurologic deficit; * inability to exercise due to orthopaedic injury; * diabetes or known heart disease; increased cardiac risk; adhd; depression; anxiety; history of moderate or severe brain injury; more than 3 prior concussions; * inability to understand spoken english.
breath, stress and health: a biocultural study of hatha yoga practice

Conditions: Stress, Physiological; Stress, Psychological

Summary: this study aims to contribute uniquely to stress, longevity, and mental health research in two ways: by identifying clear protocols of breath-based yoga-meditative practice based on original materials; that are subsequently assessed with established scientific stress, biochemical immunity and longevity markers, and validated psychological measures that relate to mental health.

this study aims to contribute uniquely to stress, longevity, and mental health research in two ways: by identifying clear protocols of breath-based yoga-meditative practice based on original materials; that are subsequently assessed with established scientific stress markers across the sympathetic-adreno-medullar (sam) axis, biochemical immunity and longevity markers, and validated psychological measures as related to mental health. the study couples emic perspectives from the traditional yoga knowledge base, both textual and practice, with empirical measures from science as an opportunity to bridge these worlds as a first known study of hatha yoga to be tackled by the means and methods of biocultural anthropology. it therefore highlights the importance of context and detail in terms of assessing human behavioral practices, where accuracy in terms of definitions, technique detail, and original purported intentions and outcomes are addressed as relevant when measuring and explaining empirical outcomes under modern research mixed methods.

Eligibility criteria:
inclusion criteria: * novice to breath-based yoga practice * multicultural international participant base * fluent in english comprehension and reading * in general good health * have a smartphone or similar device in order to receive surveys on a dedicated app exclusion criteria: * none

Keywords: yoga breath-based yoga stress management meditation hatha yoga anxiety mitigation mental health longevity
effects of aerobic exercises on dual-task performance and motor skills in children with mild cognitive impairment

Conditions: Cognitive Impairment

Summary: cognition refers to the mental processes involved in gaining knowledge and understanding, encompassing aspects such as thinking, knowing, remembering, judging, and problem-solving. these processes include attention, memory, executive functions, perception, language, and visuospatial skills. in children, cognitive development is critical for academic success, social interactions, and daily living activities. in the context of mild cognitive impairment (mci) in children, cognitive processes may be less efficient or slower than in typically developing peers.this can affect their ability to perform tasks that require simultaneous cognitive and motor functions, known as dual tasks. aerobic exercises are known to provide numerous cognitive and physical benefits, but their specific impact on children with mci has not been thoroughly investigated. the aim of study is to analyze the effects of aerobic exercises on dual-task performance and motor skills in children with mild cognitive impairment.the current study will be randomized control trial; data will be collected from government special education center johar town. the study will include patients equally divided into two groups and randomly allocated. inclusion criteria for the study will be both genders, having age between7 to 12, children with iq ranging from 50-70, who are cooperative. children with hearing or vision impairment, any neurological/musculoskeletal disorder or already involved in an intervention program will also be excluded from the study. experimental group will perform a structured aerobic exercise program and control group will do its daily routine activities. the intervention group will receive 3 sessions per week for 12weeks. each session lasted 45 min on average. outcomes to be analyzed will be dual-task performance and motor skills. tools used for data collection will be timed up and go, single leg stance, tandem stance, and 30-second sit-to-stand tests and tgmd-2. data will be analyzed through spss version 26.00.


Eligibility criteria:
inclusion criteria: * iq from 50 to 70 * who can easily understand instructions * both genders are included exclusion criteria: * hearing or vision impairment * any neurological/musculoskeletal disorder * already involved in an intervention program

Keywords: mild cognitive impairment dual-task performance aerobic exercises
urdu version of foot and ankle disability index: a reliability and validity study

Conditions: Plantar Fascitis

Summary: the purpose of this research is to translate foot and ankle disability index in urdu and determine the validity and reliability in patients with plantar fasciitis and correlate it with quality of life short form-36 and the visual analog scale.

as per recommendation of the english version of foot and ankle disability index will be translated and culturally adapted. foot and ankle disability index along with its correlation scales will be distributed in the seventy plantar fasciitis population that will be selected according to inclusion exclusion criteria and through convenience sampling technique. to check the inter and intra observer reliability of foot and ankle disability index, short form-36 to measure the quality of life and visual analog scale to measure pain will be filled by participants.

Eligibility criteria:
inclusion criteria: * inability to achieve 20 degrees of active dorsiflexion * heel pain * mid foot pain * heal swelling * mid foot swelling * achilles' tendon tightness diagnosed on the base of windlass test exclusion criteria: * recent foot injury * fracture * infections * surgical procedures * tendon injury * hypermobility * neuromuscular disorders * impaired sensation * open sores * skin disease * active deep vein thrombosis or thrombophlebitis * bruises * varicose veins * burn scars

Keywords: foot and ankle disability index plantar fascitis cultural adaptation validity urdu version reliability