Kornimate/medical-research-clean huggingface dataset:
epileptogenic zone's cartography by quantification of eeg's signal and intracerebral stimulation.

Conditions: Epilepsy

Summary: epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population. although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long term (≥ 5 years) varies from 27% to 66% according to the kind of epilepsy. it is in this context that epistim is interesting, and its aims isb a better electrophysiology delimiting of cortical networks that imply the genesis of seizures with the aim to improove surgery results. this study will rely on the intracerebral records and on corticales electrical stimulation as they are currently routinely used by epileptic patients candidates for surgery.


Eligibility criteria:
inclusion criteria : * patient from 5 to 65 years (l1121-7 l1122 2 csp), including legally protected or unable to give his consent (l1121-8 csp). * written approval of inclusion in the study from the patient or his legal representative. * patients with partial epilepsy drug resistant , justifying a seeg exploration. exclusion criteria : * patient under 5 years. * patient over 65 years. * pregnant or breastfeeeding women (l1121-5 csp). * patient deprived of liberty as a result of a judicial or administrative decision (l1121-6 csp). * patients over 18 years unable to give their free consent and not subject to a legal protection order.

Keywords: epilepsy surgery candidate eeg's signal
feasibility of an immersive virtual reality based biofeedback intervention for outpatients in rheumatology

Conditions: Rheumatoid Arthritis; Systemic Lupus Erythematosus; Spondyloarthropathy; Vasculitis

Summary: the purpose is to study the use of virtual reality (vr) and biofeedback in rheumatology clinics to help manage chronic pain in patients with rheumatologic diseases. the objective is to know the usefulness of vr/biofeedback-based therapy in the clinic.


Eligibility criteria:
inclusion criteria: * adult patients with rheumatoid arthritis, systemic lupus erythematosus, seronegative spondyloarthropathy, myositis, psoriatic arthritis, vasculitis or other autoimmune conditions. * patients must be on a stable regimen of medications. * patients should have pain, measured at the time of entry using a visual analog scale, of \>5/10 at least 4 days in the last 30 days exclusion criteria: * patients who are deemed by the study team to be unable to use the vr headset and follow instructions for any reason. * patients who have a history of vertigo and/or dizziness * patients with a history of seizure disorder
kinesiotape and dysphagia

Conditions: Dysphagia; Cerebral Palsy

Summary: dysphagia is common problem in almost all children with cerebral palsy (cp) and there is no consensus about to dysphagia therapy modalities.we aimed to investigate the short- and long-term effects of kinesio taping (kt) on dysphagia in children with cp.

there is a few studies for the effectiveness of kt application in the treatment of dysphagia and its effectiveness is controversial. these small-scale studies conducted to improve control of drooling in the oral phase of swallowing in cp. however, there are no studies that have evaluated swallowing as a whole. moreover, there is a need to carry out studies evaluating the efficacy of kt in dysphagia treatment with a high level of evidence and duration of effectivenes for a period longer than 3 months. this study is designed to answer the following research questions: "is kt application effective in the treatment of dysphagia in cp?" ''if it is effective, whether the effect of kt therapy persists more than 3 months''.

Eligibility criteria:
inclusion criteria: * children between the ages of 2 and 6 years who had oropharyngeal dysphagia (od) symptom and/or finding and were subsequently hospitalized and rehabilitated were included in this study. exclusion criteria: * patients with history of maxillary, head or neck surgery or botulinum toxin injection, structural oropharyngeal abnormality, known esophageal dysphagia and/or gastroesophageal reflux disease, who were received medical and/or physical therapy for dysphagia in the last 6 months, using drugs for seizures or spasticity as well as no oral intake and tube dependent completely for feeding were not included.

Keywords: kinesiotape swallowing cerebral palsy dysphagia
esmolol or nitroglycerin infusion for blood pressure control prior to cardiopulmonary bypass (cpb) in cardiac surgery

Conditions: Hypertension

Summary: this is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery. patients will be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary bypass (cpb).


Eligibility criteria:
inclusion criteria: * adult patients scheduled for cardiac surgery at llumc university hospital will be eligible for participation in this study. exclusion criteria: 1. severe lv (left ventricle)dysfunction (ef \< 35%). 2. emergency procedures. 3. procedures with combined carotid artery surgery. 4. patients at high risk for stroke. 5. hemodynamically significant dysrhythmias. 6. pre-existing atrial fibrillation or high degree av (atrioventricular block). 7. pacemaker dependency. 8. known sensitivity to beta blockers. 9. patient refusal.
caption ai to minimize risk of covid exposure

Conditions: COVID-19

Summary: participants scheduled for for an echocardiogram (echo) and being evaluated for, or is positive for covid-19 will be asked if they would be willing to have their echo done using a new software program on one of the hand-held ultrasound scanners. the new software program guides the investigator, or any other non-sonographer, to take the best possible pictures of the participants heart. the prior version of this software is already being used clinically and is fda approved. the main reason for using the updated version is that it's faster and better in terms of guiding the user.

to enable healthcare professionals that are not proficient in transthoracic echo (tte) to acquire images in patients being evaluated for or positive for covid-19. by leveraging the capabilities of the caption ai which is designed to train novice users on how to acquire tte, this would minimize the risk of sonographers to be exposed to covid-19. additionally, minimizing sonographer interaction with patients being evaluated for or positive for covid 19 minimizes the risk of sonographers as vectors for transmission to other patients. lastly, since the caption ai device will be dedicated to the covid wards and covid icu and not transported to other locations, use of the caption ai device will help to limit viral transmission via the surfaces of the ultrasound machine. these images will be assessed by qualified medical professionals for diagnosis.

Eligibility criteria:
inclusion criteria: * duke patients within the micu and covid overflow areas * transthoracic echocardiogram ordered by their provider * suspected or positive for covid-19. * patients who consent to participating in the study or physician discretion that information to be gained is important to the patient * patients ≥18 years old exclusion criteria: * unable to lie flat for study * patients unwilling to give consent

Keywords: echocardiogram
comparison of physical fitness and activities of the children with epilepsy and their healthy peers

Conditions: Epilepsy; Physical Activity

Summary: to investigate physical fitness and activity levels in children with epilepsy and compare the results with healthy peers.

many individuals with epilepsy are physically inactive due to the fear of seizures triggered by physical activity/ exercise, and the advices given by the family members and the health care professionals to avoid intense activity . in two studies performed about this subject, this is the probable reason why adult patients with epilepsy have a weaker physical fitness than healthy individuals in the control group. however; in a study of drawskowski et al., the avoidance of activity and exercise in individuals with epilepsy was investigated, and it was reported that the injuries and seizure problems were rare even during very intense physical activity.

Eligibility criteria:
inclusion criteria: * children who were diagnosed with epilepsy * children who can independently continue formal education, * children who do not need special education * children who have no additional neurological and neuromuscular disease (epilepsy only) * children who have a normal or higher cognitive level according to the wisc-r intelligence test * children who were volunteers to participate in the study * children whose parents volunteers to participate in the study exclusion criteria: * the disappearance of volunteerism

Keywords: childhood epilepsy physical fitness physical activity use of pedometer
comparison between pyloric preserving and non-pyloric preserving bariatric surgery with glucose challenge

Conditions: Hypoglycemia; Obesity

Summary: this study will compare glucose and simple carbohydrate sensitivity. the hypothesis is that rapid emptying of high-glycemic index foods after roux-en-y gastric bypass (rygb) causes reactive hypoglycemia. it is believed that the controlled release offered by an intact pylorus will be advantageous for long term results in bariatric surgery. this study can provide a scientific rationale, in a short duration of time, for why pylorus sparing surgery, such as the sleeve gastrectomy or duodenal switch, may offer therapeutic advantages, as compared to non-pyloric sparing surgery, namely the gastric bypass.

clinical trial objective: the objective of this clinical trial is to determine whether an intact pylorus prevents reactive hypoglycemia following challenge with liquid glucose preparation and/or solid load made of refined flour product that is a simple carbohydrate. clinical trial design: this is a prospective, non-randomized, clinical trial.

Eligibility criteria:
inclusion criteria: * the patient is greater than 18 years old; * the patient has a bmi \> 35; * patient meets standards for bariatric surgery; exclusion criteria: * the patient has an incurable malignant or debilitating disease; * the patient has been diagnosed with a severe eating disorder; * the patient is currently pregnant (pregnancy test required for confirmation for those of child bearing years); * the patient is unable to comply with the study requirements, follow-up schedule, or to give valid informed consent
comparison between natural progesterone and vaginal pessary for the prevention of spontaneous preterm birth

Conditions: Preterm Labor; Premature Birth

Summary: the aim of this study is to compare the effectiveness between the cervical pessary and the natural progesterone in reduction of preterm birth rates in pregnant women with a uterine cervical length of 25 mm or less evaluated by transvaginal ultrasonography.

preterm birth is the leading cause of perinatal morbidity and mortality. the rates of spontaneous premature labor have not changed much during the past 10 years. a significant decrease in mortality and morbidity of premature babies will only be possible if women at risk of spontaneous preterm birth are accurately identified and administered preventive therapies. ultrasonographic measurement of the cervix between 20 and 24 weeks of gestation can improve the identification of both women with single pregnancies and those with twin pregnancies at risk. asymptomatic women with a short uterine cervix (25 mm or less) are at increased risk of spontaneous premature labor. the prophylactic use of progesterone during the early phase of pregnancy in women with a history of preterm birth and those with a short cervix can prevent preterm birth. the cervical pessary is a device used also for the prevention of preterm birth. vaginal infections are also important causes of preterm birth. there are not many studies about the vaginal microbiome in pregnant women. measurement of cervical length is used as a screening test because it is inexpensive, has a short learning curve, and is well tolerated by patients. in addition, placement and removal of the pessary is an easy, accessible, and noninvasive procedure. the results on the concentration of omega 3 and preterm birth are still conflicting. the aim of this study is to compare the effectiveness of the cervical pessary and the natural progesterone in reduction of preterm birth rates in pregnant women with a uterine cervix measuring 25 mm or less in length as evaluated by transvaginal ultrasonography, assess whether there is a relationship between maternal plasma concentration of omega 3 and preterm birth, and compare the microbiome in these women. methods: a prospective randomized controlled trial including pregnant women at the time of morphological ultrasound between 20 and 23 weeks and 6 days of pregnancy. pregnant women in this gestational age with cervical length of 25 mm or less will be randomized between the conduct and the inclusion of progesterone vaginal pessary. in patients of both groups vaginal discharge sample will be collected at the time of randomization.

Eligibility criteria:
inclusion criteria: * gestational age between 20 weeks and 23 weeks and 6 days * singleton pregnancies exclusion criteria: * fetal death at randomization * major structural or chromosomal abnormality * cervical cerclage in the current pregnancy * preterm rupture of membranes diagnosed before randomization

Keywords: progesterone uterine cervix cervical pessary
atherosclerosis-progression in coronary arteries compared to periphery vessels

Conditions: Atherosclerosis

Summary: the study is a prospective-observational, explorative single-centre cohort study aimed to examine the atherosclerosis progression in coronary arteries compared to peripheral vessels (carotids, femoral arteries). atherosclerotic alterations in peripheral vessels (imt, plaque volume, plaque morphology) will be measured with ultrasound (imt measurements and 3d quantitative plaque volumetry), whereas atherosclerotic alterations in coronary arteries will be tested with cardiac computertomography (ct) (coronary artery calcium score, calcium volume score, plaque morphology). a total of 55 patients without prior known established vascular diseases will be tested. cardiac ct and ultrasonography will be performed initially. after 2 years follow-up ct and ultrasound examination will be performed to assess the changes in atherosclerotic burden. initially and after two years plasma samples will be collected and tested for traditional and novel cardiovascular risk factors. the primary endpoint of the planned study will be the correlation of the atherosclerotic progression between coronary arteries and peripheral arteries (carotids, femoral arteries). secondary endpoints will include the correlation of atherosclerotic progression with established (hypertension, smoking, diabetes, dyslipidemia) and novel risk factors (hscrp, p-selectin, cholesteryl ester transfer protein (cetp), intercellular adhesion molecule-1 (icam-1), cetp taqib polymorphism), with cardiovascular event rate, and the additional predictive value of atherosclerotic progression compared to an established risk score (score card, frs). also plaque morphology will be compared between coronary arteries and peripheral vessels.


Eligibility criteria:
inclusion criteria: * age 30-85 years, no prior established vascular diseases (cad, pad, cerebrovascular disease) no diabetes exclusion criteria: * prior myocardial revascularisation therapy (aortocoronary bypass, pci with stent implantation), coronary artery disease (cad), peripheral artery disease (pad), cerebrovascular disease (e.g.stroke), diabetes, pregnancy, lactation period, chronic renal insufficiency iiib or lower (gfr \<45ml/min), manifest hyperthyreosis
effect of antimicrobial treatment of acute otitis media on the intestinal microbiome in children

Conditions: Acute Otitis Media

Summary: this is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children. the participating children with acute otitis media are treated wither with amoxicillin, amoxicillin-clavulanate or without antibiotics. the children with allergy to amoxicillin receive a course of macrolide and they will be monitored as a separate group. the main outcomes of this trial are the changes in the intestinal microbiome after the treatment.

antimicrobial treatment of acute otitis media has been proven efficacious in children. it has been suggested that antimicrobial treatment makes a lot of harm to intestinal microbiome and may thus have effects on the child's health and wellbeing. however, data on these changes and their magnitude is scanty. this is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children. the participating children with acute otitis media are treated wither with amoxicillin, amoxicillin-clavulanate or without antibiotics. the children with allergy to amoxicillin receive a course of macrolide and they will be monitored as a separate group. the main outcomes of this trial are the changes in the intestinal microbiome after the treatment.

Eligibility criteria:
inclusion criteria: * acute symptoms of respiratory infection and * signs of inflammation on the tympanic membrane in otoscopy and * middle ear effusion found in pneumatic otoscopy exclusion criteria: * suspected or proven complication of acute otitis media (for example acute mastoiditis or perforated tympanic membrane) * severe acute otitis media: severe pain and fever \> 39 degrees c * bilateral acute otitis media in a child younger than 2 years * primary or secondary immunodeficiency or downs syndrome * impaired general condition or suspected severe bacterial infection * allergy to both amoxicillin and macrolide * acute otorrhea through tympanostomy tube * antimicrobial treatment ongoing or during previous 7 days

Keywords: children intestinal microbiome microbiota antimicrobial course amoxicillin amoxicillin-clavulanate macrolide
a study to assess the effect of tocilizumab + dmard therapy on signs and symptoms in patients with moderate to severe active rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this 2 arm study will compare the safety and efficacy, with regard to reduction of signs and symptoms, of tocilizumab versus placebo in combination with traditional disease-modifying anti-rheumatic drug (dmard) therapy in patients with moderate to severe active rheumatoid arthritis (ra) who have had an inadequate response to current dmard therapy. patients will be randomized to receive tocilizumab 8mg/kg iv or placebo iv every 4 weeks, in conjunction with stable dmard therapy. the anticipated time on study treatment is 3-12 months, and the target sample size is 500+ individuals.


Eligibility criteria:
inclusion criteria: * patients at least 18 years of age with moderate to severe active ra for at least 6 months; * inadequate response to current anti-rheumatic therapies, including 1 or more traditional dmards; * stable dmard therapy for at least 8 weeks before entering study; * patients of reproductive potential must be using reliable methods of contraception. exclusion criteria: * major surgery (including joint surgery) within 8 weeks before entering study, or planned surgery within 6 months after entering study; * patients who have previously failed treatment with an anti-tumor necrosis factor agent; * women who are pregnant or breast-feeding.
impact of stigma on compliance to medication in functional dyspepsia

Conditions: Functional Gastrointestinal Disorders; Adherence, Patient

Summary: to date, no study exists that evaluates whether functional dyspepsia patients experience stigma and how stigma may influence adherence. thus, the investigators aim to evaluate the relationship between functional dyspepsia and stigma, and explore possible ways to improve treatment adherence.

due to the functional but refractory nature of functional gastrointestinal diseases (fgids), large number of patients who suffer from fgids may not be able to fully understand their diagnosis, especially when they were told that they had no organic disease and their symptoms had a psychosomatic origin rather than a gastrointestinal one. moreover, subjects with fgids have concerns and negative perceptions about medications, particularly in the presence of psychiatric comorbidity. fearing of being labeled as insane or incapability, many patients with psychosomatic symptoms choose to conceal their illness to family, colleagues and doctors. these factors may affect willingness to initiate neuromodulator regimens and treatment adherence.

Eligibility criteria:
inclusion criteria: * 18-70 years old; * met the rome iv criteria for fd; * absence of abnormalities in physical examination, laboratory tests (including a routine blood test, blood glucose, and liver function examination), abdominal ultrasonography and upper gi endoscopy within 6 months; * absence of h. pylori infection; * generalized anxiety disorder scale (gad-7) ≥ 1 or patient health questionnaire depression scale (phq-9) ≥ 5 exclusion criteria: * any evidence of organic digestive diseases; * other fgids such as ibs; * severe psychological symptoms with gad-7 ≥ 11 or phq-9 ≥15; * pregnancy or breastfeeding; recent myocardial infarction or cardiac arrhythmias; * previous gastric surgery; * use of ppis, psychoactive drugs or other drugs that might affect gastric function within 6 months
microparticles and bronchiolitis obliterans syndrome

Conditions: Bronchiolitis Obliterans

Summary: the main long-term complication of lung transplantation is chronic lung allograft dysfunction (clad). bronchiolitis obliterans syndrome (bos) is the most frequent presentation of clad. bos leads to a progressive loss of lung allograft function, with recurrence of dyspnea and airflow limitation. in some advanced cases, patients need a lung re transplantation. the mechanisms of bos are not completely elucidated, and there are no early markers or specific treatment available for this condition. microparticles (mps) are submicron plasma membrane fragments released into the vascular compartment or the pericellular space in response to cell activation, injury or apoptosis. broncho alveolar and circulating mps may reflect cellular insults of the lung allografts. therefore, mps could be viewed either as biomarkers or as effectors of the chronic inflammatory or procoagulant processes leading to bronchiolitis obliterans syndrome. the investigators plan to include 60 patients before lung transplantation at our centre in strasbourg (france). follow-up will be requested at the base of usual care (spirometry, blood sampling, bronchoscopy with broncho-alveolar lavage \[bal\]). the investigators will measure at one month, one, two and three year post transplantation, the total concentration of mps in plasma and bal and characterize their phenotype. the investigators objective is to demonstrate correlation between total mps concentration in broncho-alveolar lavage fluid (balf) and the occurrence of bronchiolitis obliterans syndrome at three years post lung transplantation.


Eligibility criteria:
inclusion criteria: * every adult (\>18 years) patient on lung transplant waiting list * patients who give a written informed consent * patients affiliated to a social security regimen exclusion criteria: * patients on lung transplant waiting list for bos * patients who cannot sign an informed consent form (emergency situation, patient with understanding difficulties...)