Kornimate/medical-research-clean huggingface dataset:
high flow therapy vs hypertonic saline in bronchiolitis

Conditions: Acute Viral Bronchiolitis

Summary: the purpose of this study is to demonstrate that heated, humidified, high-flow nasal cannula (hhhfnc) is superior to hypertonic saline solution (hss) in the treatment of moderate acute viral bronchiolitis in infants in improving respiratory distress and comfort and reducing length of hospital stay (los) and admission to pediatric intensive care unit (picu).


Eligibility criteria:
inclusion criteria: * children aged 6 months or less * moderate (respiratory distress assessment instrument score of 4 or greater) viral bronchiolitis (as defined by mcconnockie) * meeting admission criteria exclusion criteria: * history of prematurity * chronic lung disease * cystic fibrosis * congenital heart disease * neuromuscular disease * airway anomalies * immunodeficiency * those requiring immediate intubation and ventilation.

Keywords: bronchiolitis hypertonic saline solution high-flow oxygen therapy respiratory distress comfort
prognosis and risk factors for acute kidney injury

Conditions: Acute Kidney Injury

Summary: the aim of our study is to analyze the accurate diagnosis and prognosis of acute kidney injury (aki) based on its severity and to define long-term clinical and socioeconomic outcomes. investigators defined the aki group among adults aged 20 years or older who visited enrolled center and underwent at least two blood tests, including serum creatinine, within an interval of 7 days or less and a control group was matched 1:1 to the aki group based on age, sex, year of visit, and baseline kidney function, forming the study population. investigators then collected and analyzed various clinical, laboratory, and hospitalization records including demographic data, anthropometric data, laboratory data, and medical history.


Eligibility criteria:
inclusion criteria: * adults over 20 years old who visited parcitipating medical center (seoul national university hospital, bundang seoul national university hospital, smg-snu boramae medical center, keimyung university dongsan medical center) between 2006 and 2021 * the aki group is defined as individuals meeting the aki diagnostic criteria of the kdigo guideline (an increase in serum creatinine of ≥0.3 mg/dl or ≥1.5 times the baseline level) is enrolled. * the control group is defined as individuals from the study population who do not meet the aki criteria and are matched 1:1 based on age, sex, year of visit, and baseline renal function. exclusion criteria: * individuals under 20 years old * individuals who did not undergo serum creatinine tests meeting the criteria * individuals with pre-existing end-stage kidney disease (eskd) who have undergone dialysis or kidney transplantation
efficacy of a combined linguistic/communication therapy in acute aphasia after stroke

Conditions: Aphasia, Acquired

Summary: linguistic training is traditionally the gold standard for rehabilitation of aphasia after stroke and efficacy criteria count early stage, intensity as well as personalized treatment. to date, no clear evidence showed a specific effect of any therapy in the acute phase of aphasia after stroke. this study aims to compare the effect of a combined therapy (linguistic/communication) versus a linguistic therapy on communication performance in patients in the acute phase of aphasia after a first stroke.

twenty to 25% of strokes cause aphasia. speech and language therapy is the well-known standard treatment of aphasia after stroke although it is based on weak scientific evidence. to date, the efficacy criteria of aphasia rehabilitation are early stage, intensity as well as personalized treatment. usually these patients receive in acute phase a linguistic training focused on the linguistic impairment. this approach is based on the cerebral plasticity postulate. however the superiority of this practice compared to other methods has never been shown. moreover the benefit of the combination gathering linguistic treatment with communication treatment has to our knowledge never been studied. in the present study investigators propose to compare the effect of a combined linguistic/communication rehabilitation versus a linguistic treatment. to do so, investigators will recruit patients with aphasia after a first stroke, in the acute phase. after a allocation to the " combined " and " linguistic " groups, all the patients will have a comprehensive language and neuropsychological assessment before and after 3 months of rehabilitation, and finally 6 months after the onset. the "linguistic" group will have a rehabilitation only focused on linguistic processes whereas the "combined" group will have a linguistic training as well as communication training. the therapy will be personalized and the therapists will exclusively use standardized linguistic and/or communication toolboxes of rehabilitation containing dedicated activities.

Eligibility criteria:
inclusion criteria: * first stroke * inclusion at the acute phase (\< 7 days) * patient registered at the social security system * french as usual language * aphasia severity score measured by the boston diagnostic aphasia examination (bdae) scale ≥ 1 and ≤ 4 * consent signed by the patient or if not, by the caregiver exclusion criteria: * cognitive impairment before the onset (iqcode \> 3.4) * alcohol or drug addiction * untreated psychiatric disease, * uncorrected sensory impairment * evolutive pathology * adults protected by law * participation to another research

Keywords: aphasia rehabilitation communication linguistics
a study of stress heart imaging in patients with diabetes at risk for coronary disease.

Conditions: Diabetes

Summary: the study is designed to see if stress heart imaging can be used as a screening exam in patients with diabetes and risk factors of developing of coronary artery disease and experiencing future cardiac events.


Eligibility criteria:
inclusion criteria: * history of diabetes for at least 5 years, with a least 2 risk factors (i.e. hypertension, elevated cholesterol levels, history of or current smoker, obese, family history of heart disease) \& atypical chest pain. exclusion criteria: * typical chest pain being treated with medication, unable to exercise, previous confirmed heart disease
extracorporeal shockwave therapy for the treatment of refractory chronic angina pectoris

Conditions: Refractory Angina Pectoris

Summary: low intensity shockwaves have been proven in animal studies to induce local growth of new blood vessels from existing ones. the hypothesis of this study is that shockwave therapy could improve the symptoms of patients with refractory angina not amenable to revascularization with angioplasty or bypass surgery.

low intensity shockwaves (1/10 the ones used in lithotripsy) are delivered to myocardial ischemic tissue. shockwaves are created by a special generator and are focused using a shockwave applicator device. the treatment is guided by standard echocardiography equipment. the shockwaves are delivered in synchronization with patient r-wave to avoid arrhythmias. the treatment is painless. at first, the patient undergoes stress- pet testing to identify the ischemic areas. following that, the same area is localized by the ultra-sound device and the shockwaves are focused to the ischemic area. several treatments are required for optimal results.

Eligibility criteria:
inclusion criteria: * diagnosed with chronic stable angina pectoris. * documented myocardial segments with reversible ischemia * ap ccs class of iii-iv. * stable dosage of medication used to treat angina for at least 6 weeks prior to enrollment. * exercise tolerance time \< 10 min (modified bruce) * two ett tests results (within two weeks) averaging no more than 25% of their mean * documented epicardial coronary artery disease not amenable to angioplasty or cabg. * signed an irb approved informed consent form. * life expectancy of \> 12 months. exclusion criteria: * intraventricular thrombus * malignancy in the area of treatment * severe copd * no smoking during the study procedure * mi less \< 3 months prior to treatment * severe valvular disease * child bearing potential

Keywords: extracorporeal shockwave therapy myocardial ischemia refractory angina
efficacy study of zoledronic acid and teriparatide combination therapy in women with osteoporosis

Conditions: Osteoporosis

Summary: the purpose of this study is to assess the effects of zoledronic acid administered at the same time with teriparatide compared to zoledronic acid alone and teriparatide alone on bone mineral density (bmd) gain in the lumbar spine and total hip


Eligibility criteria:
inclusion criteria: * postmenopausal (pmo) women between 45 and 89 years of age. * bone mineral density t score of -2.5 or less at femoral neck, total hip or lumbar spine or * bone mineral density t score of -2.0 or less at femoral neck, total hip or lumbar spine with at least one documented osteoporotic vertebral fracture or a previously documented history of an osteoporotic clinical non-vertebral fracture not due to excessive trauma exclusion criteria: * any prior use of strontium * any past or active kidney disease or problems with kidney function * prior treatment with any intravenous (i.v.) or oral bisphosphonate (such as but not limited to alendronate, risedronate and pamidronate) longer than 3 months consecutively. if bisphosphonate exposure is less than or equal to 3 months , a washout period of 1 year to randomization is required * calcium levels in blood within the normal range * normal liver function * non-osteoporotic forms of metabolic bone disease such as and not limited to paget's disease of bone, osteomalacia, osteogenesis imperfecta or multiple myeloma * less than 3 evaluable lumbar (l1-l4) vertebrae for dual energy x-ray absorptiometry (dxa) measurement * treatment with osteoporotic therapies such as raloxifene, calcitonin or hormone replacement therapy within 3 months of randomization * allergy or previous exposure to teriparatide other protocol-defined inclusion/exclusion criteria may apply

Keywords: bone mineral density (bmd) c-telopeptides (ctx) dual x-ray absorptiometry (dxa) pro-collagen type 1 n-propeptide (p1np) teriparatide zoledronic acid osteoporosis postmenopausal women
respiratory exercise diary in major abdominal surgery

Conditions: Pulmonary Complication

Summary: postoperative pulmonary complications are common and lead to increased morbidity and mortality in patients. these complications are observed especially after major surgical interventions. breathing exercises performed with or without the use of a device are extremely important in preventing postoperative pulmonary complications. breathing exercises that increase total lung capacity by encouraging the use of the diaphragm reverse alveolar collapse and postoperative hypoxemia. this study aim to determine the effect of postoperative respiratory exercise diary use in patients undergoing major abdominal surgery on dyspnea, fatigue, respiratory parameters (respiratory rate, spo2, cough, sputum), early pulmonary complications, spirometry use and functional capacity.the research is planned to be conducted in a single-blind, randomized controlled manner. in the study, 60 patients (30 intervention and 30 control) who underwent major abdominal surgery will be included.data will be collected using the patient introduction form, visual analogue scale, medical research board scale, 2-minute walk test, breathing exercise diary and patient follow-up chart.patients in the intervention and control groups will be visited by the researcher for 3 postoperative days, respiratory parameters, cough, and sputum status will be recorded in the patient follow-up chart, and the use of a respiratory exercise diary will be evaluated.


Eligibility criteria:
inclusion criteria: * undergoing elective surgery * receiving general anesthesia * having major abdominal surgery (colorectal surgery, gastrectomy, liver resection, pancreatectomy) * staying in the general surgery service for at least 3 days after the surgery * becoming literate exclusion criteria: * psychoactive drug use * having alzheimer's or dementia * having chronic respiratory diseases (copd, asthma)

Keywords: general surgery breathing exercises dyspnea fatigue
incidence of influenza infections and determination of vaccination coverage rate among healthcare workers

Conditions: Influenza; Vaccination; Attitude of Health Personnel

Summary: the main aim of research is to determine of the prevalence of influenza virus and influenza vaccination coverage rate among hospital and gps healthcare workers. course of research: participation in the study is voluntary and carried out after the consent of the examined person. the examination consists of: 1) completing the questionnaire and 2) taking the throat swab twice by the researcher. two throat swab samples will be taken at the same time. both samples will be used for virological examination to determine the presence of influenza virus material using non-invasive tests: one sample will be analyzed by a quick 'on-site' test - flu sensdx kit, while the other sample will be transported to the laboratory, where the reverse transcriptase polymerase chain reaction (rt-pcr) - reference method - will be performed to confirm the presence of influenza genetic material. swabs are planned to be collected during the 2019/2020 influenza epidemic season (january-march). in the last stage of the study, the results obtained from the survey questionnaire and the results of virological tests will be subject to statistical analysis and based on the data obtained, conclusions will be drawn from the study, indicating their practical application. the results obtained from this study will be used to develop a quality improvement program to control influenza virus infection, which will improve the safety of both patients and medical staff.


Eligibility criteria:
inclusion criteria: * healthcare worker of selected general practices or hospitals wards

Keywords: influenza vaccination coverage rate healthcare workers general practice point of care testing
impact of vitamin d level and supplement on sle patients during covid-19 pandemic

Conditions: Covid19

Summary: aim of the work impact of serum vit d level in sle patients with covid-19 disease on severity of infection, duration of covid-19 disease course, fatigue development as a complication for both sle and covid-19 and assess impact of prior chloroquine on covid-19 disease outcomes patients and methods 38 sle patients previously diagnosed and on different lines of lupus management. participants were presented to chest outpatient clinic and emergency hospital, mansoura university with manifestation suggesting covid-19 infection. serum vit d was measured in serum by elisa.

primary objective: assess the impact of serum vit d level in sle patients with covid-19 disease on severity of infection and pandemic treatment outcome. secondary objectives: * effect of serum vit d level in sle patients on duration of covid-19 disease course and fatigue development as a complication for both sle and covid-19 * impact of prior chloroquine on covid-19 disease outcomes * correlation of serum vit d level with different laboratory investigations at time of covid-19 outbreak

Eligibility criteria:
inclusion criteria: * - sle patients previously diagnosed * patients are not suffering from malignancies. * patients have no organ failure nor uncontrolled medical illness. * recent covid-19 infection exclusion criteria: * - pregnant, lactating females * concurrent malignancies * patients with other autoimmune disease
perioperative chemotherapy plus cetuximab versus chemotherapy alone for high risk resectable colorectal liver metastasis

Conditions: Colorectal Cancer Stage IV; Metastasis

Summary: this study was designed to analyze the prognosis and recurrence predictive factors of high risk patients (clinical risk score≥3) of resectable colorectal liver metastasis. the efficacy of perioperative chemotherapy plus cetuximab and chemotherapy alone was compared for these patients.

resection could prolong the survival of colorectal liver metastasis patients, however,the curative resection rate was still low and more than 2/3 of the patients would experience tumor recurrence.this study was designed to formulate a more accurate and individual evaluation system via the multivariate analysis. up to now, there was no data to demonstrate the addition of cetuximab to perioperative chemotherapy could decrease recurrence and prolong survival for ras wild-type, high risk(clinical risk score≥3) resectable colorectal liver metastasis patients. this study was also designed to elucidate this question and to observe the objective response rate(orr) and the safety data of the regime.

Eligibility criteria:
inclusion criteria: * good performance status * pathologic diagnosis of colorectal cancer * rat sarcoma viral oncogene homolog(ras) wild-type * radiologic confirmation the resectability of liver metastases * enough future liver remnant * clinical risk score≥3 * treatment naive * extra-hepatic metastases could be resected completely, if exist exclusion criteria: * poor performance status, could not tolerate chemotherapy or operation * other malignancy history or synchronously * extra-hepatic metastases could not be resected completely, if exist * received other treatment previously

Keywords: colorectal liver metastasis preoperative chemotherapy targeted therapy
comparison of escitalopram combination in adult patients with major depressive disorder

Conditions: Major Depressive Disorder

Summary: escitalopram is the s-enantiomer of citalopram. both escitalopram and citalopram are selective serotonin reuptake inhibitors (ssris) and are used to treat depression in adults. this study is designed to evaluate the efficacy and safety of a fixed-dose escitalopram combination relative to its component monotherapies and to placebo in patients with major depressive disorder.


Eligibility criteria:
inclusion criteria: * patients must meet diagnostic and statistical manual, fourth edition (dsm-iv) diagnostic criteria for major depressive disorder. * the patient's current depressive episode must be at least 12 weeks in duration. exclusion criteria: * women who are pregnant, women who will be breastfeeding during the study, and women of childbearing potential who are not practicing a reliable method of birth control. * patients who currently meet dsm-iv criteria for: a. bipolar disorder; b. schizophrenia or any psychotic disorder; c. obsessive-compulsive disorder; d. mental retardation or any pervasive developmental disorder or cognitive disorder. * patients who are considered a suicide risk. * patients with a history of seizure disorder, or any history of seizure, stroke, significant head injury, or any other condition that predisposes toward risk of seizure.

Keywords: depression major depressive disorder escitalopram
correlation study between mental behavioral symptoms in dementia patients and mood disorders of caregivers

Conditions: Dementia

Summary: traditionally, the more severity of dementia patients, the heavier the burden of the comparators, and in the clinical observation,the dementia patients with rich mental behavior symptoms are more burdened. therefore, exploring the impact of psychological burden and different subtypes of different dimensions with behavioral and psychological symptoms (bpsd) will more comprehensive understanding of the factors affecting the burden of caregivers. the starting point of this project is to analyze the relationship between the types of mental behavior symptoms of dementia patients and the emotional disorders of caregivers. the topic will analyze the correlation of psychological burden of caregivers and different symptom dimensions from the perspective of refinement, helping more effective identifying high-burden mental behavior symptoms in clinically , judging the risk of emotional problems in caregivers, and adopting better humanities or medical care, so that dementia patients can better adapt to care and improve the mental health of caregivers.


Eligibility criteria:
inclusion criteria: 1. age is greater than 18 years old, gender is not limited 2. comply with icd-10 diagnostic criteria, diagnosed with dementia, including alzheimer's disease, vascular dementia, frontotemporal dementia, dementia with lewy body, dementia caused by parkinson's disease exclusion criteria: 1. senile schizophrenia; 2. senile depression; 3. cognitive impairment caused by endocrine system diseases (such as decreased thyroid and adrenal function); 4. cognitive impairment or dementia caused by serious diseases such as cardiovascular, lung, liver, kidney, and hematopoietic system; 5. cognitive impairment or dementia caused by alcohol, drug use, psychotropic drugs; 6）other physical or chemical factors that cause cognitive impairment or dementia-
rhbmp-2 vs autologous bone grafting for the treatment of non-union of the docking site in tibial bone transport

Conditions: Pseudarthrosis

Summary: when there is a bone defect, bone transport is used to bridge the defect. frequently, the bone in the docking site (where the transported bone comes together) doesn't heal. the objective is to study the effectivity of rhbmp-2 (inductos) to stimulate bone healing, in order to find new techniques to treat non-union of long bones. the method of the study is a randomized controlled trial, to compare rhbmp-2 and autologous bone grafting in stimulating bone healing in the docking site.


Eligibility criteria:
inclusion criteria: * patients treated with bone transport (ilizarov technique) and have non-union of the docking site, which is characterized by absence of bridging callus after two months of compression in the docking site. exclusion criteria: * allergy for inductos * active growth, * malignancy * infection * pad * pathological fracture
drug-drug interaction of bi 201335 and microgynon

Conditions: Hepatitis C, Chronic

Summary: this study will investigate possible effect of multiple oral doses of bi 201335 on the steady state pharmacokinetics of ethinylestradiol and levonogestrel


Eligibility criteria:
inclusion criteria: 1. healthy female subjects exclusion criteria: 1. any relevant deviation from healthy conditions