Kornimate/medical-research-clean huggingface dataset:
strategies to improve asthma and treatment of asthma in canadians

Conditions: Asthma

Summary: our study will enroll 644 randomly-selected canadians who have been diagnosed with asthma by a physician within the previous five years. it will be determined what diagnostic tests were initially performed to make this diagnosis. participants will undergo lung function testing over 6-8 weeks to determine their respiratory status and to confirm they have asthma. participants may be followed up to one year depending on their test results.


Eligibility criteria:
inclusion criteria: 1. patient must have a recent diagnosis of asthma by a physician. diagnosis of asthma must have occurred within 5 years prior to entry into the study. 2. patient must be at least 18 years old. exclusion criteria: 1. patients in whom methacholine challenge is contraindicated * patients using chronic oral prednisone. * patients with heart attack or stroke within three previous months, and those with known aortic or cerebral aneurysms. * pregnant patients (unknown effect of methacholine on the fetus) and breastfeeding patients (unknown whether methacholine is excreted in breast milk). 2. patients unable to provide informed consent. 3. patients not able to perform spirometry and/or methacholine challenge testing. 4. patients who have a greater than 10 pack-year smoking history (this will exclude patients with possible copd). 5. patients who currently have active pulmonary tuberculosis 6. patients who have had eye surgery in the past 3 months or who have a detached retina 7. patients involved in another interventional asthma study
immediate effect of dry needling on trigger points

Conditions: Shoulder Pain

Summary: the immediate effects (0-30 minutes) of a dry needling intervention on a trigger point on their viscoelastic properties (tone, elasticity and stiffness)

objectives: to investigate the immediate effects of a dry needling puncture on the viscoelastic properties (tone, stiffness and elasticity) of a trigger point (tp) located in the infraspinatus muscle in participants with non-traumatic chronic shoulder pain. methods: forty-eight individuals who presented non-traumatic chronic shoulder pain were recruited. the presence of a tp in the infraspinatus muscle of the painful side was confirmed by an experienced physiotherapist with a palpatory exam according to travell and simons criteria. the tp was marked and the viscoelastic properties including tone, stiffness and elasticity were measured with the myotonpro device by an evaluator. after the first set of measurements (t1), an experienced physiotherapist applied a dry needling puncture to the tp with a pistoning technique to obtain a local twitch response (ltr) with an optimed 40 x 0.30 mm single use acupuncture needle. the same set of measurements was repeated immediately after the dry needling (t2) and 30 minutes later (t3). repeated measures anova and post-hoc tests were used to assess changes in viscoelastic properties over time with a significant level set at 0.05.

Eligibility criteria:
inclusion criteria: 1. present with chronic shoulder pain of non-traumatic origin (rated at least 2/10 on a numeric rating scale (nrs) for more than 3 months. the pain had to be located in the shoulder area or referred in the area of the infraspinatus as described by travell and simons (1999); 2. have a hyperirritable spot within a palpable tight band that reproduced the participant's pain when compressed by palpation; and 3. have a body mass index (bmi) lower than 28 exclusion criteria: 1. diagnosis of capsulitis, cancer, or metastasis; 2. previous shoulder or thorax surgery or a mastectomy; 3. shoulder girdle bone fracture; 4. c4-c5 or c6 radiculopathy; 5. known osteoporotic profile (positive bone densitometry); 6. apparent atrophy of the infraspinatus fossa (visual interpretation) and 7. contraindications to receive a dn intervention

Keywords: myofascial trigger points, dry needling, stiffness
retrospective patient satisfaction survey in subjects with tecnis intra ocular lenses and cataracts surgery

Conditions: Cataract

Summary: define what factors correlate with higher degrees of patient satisfaction and dissatisfaction among patients who have recently undergone cataract surgery.


Eligibility criteria:
inclusion criteria: * patients with uncomplicated bilateral cataract surgery with a tecnis multifocal or monofocal implant completed at least 60 days before the survey date. * patient with and without astigmatic keratotomy will be included. exclusion criteria: * patients with visually significant co-morbidities (corneal, retina, optic nerve disease) that could affect their satisfaction with surgery * patients with surgical complications either during or after surgery (capsule tears, iris trauma, decentered iol, cystoid macular edema, etc.) * patients with ≥ grade 1 posterior capsule opacity at their last visit
phone coaching and internet-delivered weight loss

Conditions: Obesity

Summary: the purpose of this study is to examine whether adding phone coaching to an internet-based weight loss program can improve weight loss outcomes at 4 months and 1 year. all individuals will receive a 4-month, internet-delivered weight loss program followed by an 8-month internet-delivered weight loss maintenance program. some individuals will also be selected to receive either 3 weeks or 12 weeks of phone coaching. assessments of weight, diet, physical activity, and psychosocial factors will occur at baseline, 4 months, and 1 year.

all individuals enrolled in this study will receive a 4-month internet-based weight loss program followed by an 8-month internet-based weight loss maintenance program. during the first 4 months, each week individuals will be asked to view a 10-15-minute multi-media lesson (one per week). these lessons focus on behavioral principles for changing diet and physical activity behaviors. participants are also given weight loss, calorie intake, and physical activity goals. they are taught how to self-monitor this information and are instructed to submit it weekly on the study website. automated, weekly individualized feedback is provided. following the 4-month weight loss program participants will receive an 8-month weight loss maintenance program. during this time, they will be asked to view monthly video lessons which focus on strategies for successful wl maintenance and instructed to continue to self-monitor weight, calorie intake, and physical activity minutes on the study website for one week per month. automated, monthly feedback is provided. in addition to the internet program described above, some individuals enrolled in this study will be selected to receive phone coaching. those selected for 'brief' phone coaching will be asked to complete 3 phone calls with a coach between weeks 5-8 of the study and those selected to receive 'extended' phone coaching will be asked to complete 12 phone calls with a coach between weeks 5-16. the first coaching call will be approximately 45 minutes in duration and all subsequent calls will be approximately 15 minutes in duration. the coach will assist participants in developing a meal plan, problem solving around current barriers, and goal setting. upon completion of all coaching calls participants will have no additional interaction with the coach, but will remain enrolled in the internet program. assessments will occur at baseline, 4, and 12 months.

Eligibility criteria:
inclusion criteria: * age 18-70 * bmi: 25-45 kg/m2 * regular internet access exclusion criteria: * currently pregnant, \<6 months post-partum, nursing, or planning to become pregnant within the next 12 months. * current enrollment in a commercial weight loss program or other weight loss research study * currently taking weight loss medications * previously had bariatric surgery * inability to walk 2 blocks without stopping * any medical condition for which weight loss, dietary restriction, or physical activity is contraindicated

Keywords: obesity weight loss exercise diet phone coaching
foot mechanical stimulation for treatment of gait and gait related disorders in parkinson's disease and progressive supranuclear palsy.

Conditions: Idiopathic Parkinson's Disease; Progressive Supranuclear Palsy

Summary: the purpose of this research study is to evaluate safety and effectiveness of foot mechanical stimulation to improving gait and gait related disorders in parkinson disease and progressive supranuclear palsy both stable and with motor fluctuation.


Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic pd or psp by uk brain bank criteria, * able to walk 25 feet unassisted or with minimal assistance; * on stable doses of parkinson's medications for at least 2 weeks prior to study onset; * endurance sufficient to stand at least 20 minutes unassisted per patient report. exclusion criteria: * other significant neurological or orthopedic problems.
use of hextend in trauma

Conditions: Trauma

Summary: this is a chart review of all trauma patients during the specified time period. the purpose of this study is to examine the effects of resuscitation with hextend after trauma, in the adult population. the authors hypothesize that when compared to patients resuscitated with standard of care, resuscitation with hextend will result in a mortality difference.


Eligibility criteria:
inclusion criteria: * admission to the trauma center exclusion criteria: * pregnant women, children, psychiatric patients and prisoners.

Keywords: combat casualty care hextend colloid
covid-19 serology in people living with hiv in hong kong

Conditions: HIV Infections; SARS-CoV-2 Infection; Vaccination; Infection

Summary: immunodeficiency associated with human immunodeficiency virus (hiv) infection could predispose people living with hiv/aids (plha) to defective serological responses following infection or vaccination. to evaluate the health outcomes of coronovirus disease-2019 (covid-19) and hiv co-infection, plha and hiv-uninfected persons in hong kong are invited to join a study for understanding their clinical characteristics and for tracking their levels of antibodies against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) over a one-year observation period after infection or vaccination. the results could inform the development of prevention and control strategy for plha in response to the emerging coronavirus threats.

the aim of the study is to evaluate the health outcomes of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) co-infection in people living with hiv/aids (plha) in hong kong, with the specific objectives of (a) describing the clinical and immunological characteristics of coronavirus diseases-2019 (covid-19) in plha; (b) tracking the cd (cluster of differentiation) 4/cd8 lymphocytes changes following sars-cov-2 infection; (c) assessing the temporal changes of sars-cov-2 serology profile of plha following sars-cov-2 transmission and vaccination. this is a descriptive study involving the analyses of data derived from the testing of plha and non-infected controls at different time-points, following sars-cov-2 infection / covid-19 or vaccination, in conjunction with routinely collected clinical data in the setting of hong kong. the total number of subjects to be recruited is 800, of which 50 would be hiv/sars-cov-2 co-infected persons. in order that their serological responses to sars-cov-2 could be interpreted in perspective, 400 hiv uninfected adults would be recruited for comparison. separately, 400 plha and 50 healthy adults who have received sars-cov-2 vaccination would be recruited to form another control group. blood sampling would be performed upon diagnosis of covid-19 disease when a sars-cov-2 infected person is hospitalized for treatment, or after vaccination. this would be repeated after discharge for hospitalized patients and on follow-up at the following time-points: 3, 6, 12, 18 and 24 months. plasma would be separated from the collected blood samples and stored at -20°c before testing. the levels of antibody to sars-cov-2 nucleocapsid and spike protein would be measured using enzyme linked immunosorbent assay (elisa) method, while surrogate virus neutralization test (svnt) would be performed to track the changes of sero-protection. .

Eligibility criteria:
inclusion criteria: * adults of age 18 or above, with * known hiv status * infection with sars-cov-2 or completion of vaccination against sars-cov-2 exclusion criteria: * unable to communicate in written/spoken chinese or english * concurrent mental illnesses * prisoners * absence of consent

Keywords: hiv covid-19 sars-cov-2 vaccination co-infection antibody responses
predicting response and toxicity in patients receiving lonafarnib for breast cancer

Conditions: Breast Cancer

Summary: this is a tumor and serum collection study for patients with advanced breast cancer receiving treatment with lonafarnib.

outline: this is a multi-center study. sample collection: * tumor sample * serum sample treatment regimen: * all registered patients must be planning treatment with lonafarnib

Eligibility criteria:
inclusion criteria: * written informed consent and hipaa authorization for release of personal health information. note: hipaa authorization may be included in the informed consent or obtained separately. * age \> 18 years. * planned treatment with lonafarnib for metastatic breast cancer. * must consent to have a biopsy performed to obtain fresh tissue or be able to identify a formalin fixed paraffin embedded (ffpe) tissue block in which tumor samples can be obtained to complete the testing for this study. exclusion criteria: * planned treatment with any other treatment regimen
glucose-insulin-potassium therapy improves lactic acidosis in liver transplantation

Conditions: Liver Transplantation

Summary: lactic acidosis is a common phenomenon occurring during orthotopic liver transplantation (olt), especially during the anhepatic and early postreperfusion phases. however, little drugs effectively decrease the degree of lactic acidosis when it happens. the aim of this study is to explore whether glucose-insulin-potassium(gik) infusion can relieve metabolic acidosis and improve perioperative outcome in patients undergoing olt.

intraoperative metabolic acidosis begins soon after graft reperfusion and persists for several days. the current standard treatment for severe acidosis during olt is nahco3, although it may compromise myocardial performance, exacerbate lactic acid accumulation and cause central nervous system demyelination. surgical procedure is a primary source of endogenous lactic acid production, especially visceral ischemia originating from anhepatic stage. the present study thus hypothesized that gik solution may improve metabolic acidosis in olt patients through its unique effects of metabolic alleviation. patients for orthotopic liver transplantation was enrolled and received either gik or placebo. gik or placebo infusion started after anesthesia induction. intraoperative measures were mean arterial pressure, hr, arterial blood gases, lactate, glucose, na, liver and renal function indexes. outcome measures were time to tracheal extubation, intensive care unit, length of stay, complications, hospital length of stay, requirement for postoperative plasma transfusion, retransplantation, and perioperative mortality.

Eligibility criteria:
inclusion criteria: * patients who were to undergo olt exclusion criteria: * diabetes mellitus, hyperkalemia on arrival (k+ \> 5.5 meq/l) and the inability to give informed consent
vitamin k and glucose metabolism in adults at risk for diabetes (vita-k 'n' adults study)

Conditions: Obesity; Insulin Resistance; Insulin Sensitivity; Beta-Cell Dysfunction; Prediabetes

Summary: given that glutamate carboxylation or decarboxylation is key to the metabolic role of osteocalcin (at least in mouse models) and that carboxylation is vitamin k dependent, it is critical to isolate the effect of vitamin k manipulation on carboxylation of osteocalcin and its subsequent effect on glucose metabolism in clinical trials. the purpose of this randomized, double-blind, placebo-controlled clinical trial in adults is to determine whether eight weeks of daily supplementation with vitamin k2 (menaquinone-7) can improve markers in blood associated with diabetes risk.


Eligibility criteria:
inclusion criteria: 1. healthy adults between 18 and 65 years old 2. subject understands the study protocol and agrees to comply with it 3. informed consent form signed by the subject exclusion criteria: 1. subjects using vitamin supplements containing vitamin k 2. subjects with (a history of) metabolic or gastrointestinal diseases including hepatic disorders 3. subjects presenting chronic degenerative and/or inflammatory diseases 4. subjects receiving systemic treatment or topical treatment likely to interfere with evaluation of the study parameters (salicylates, antibiotics) 5. subjects receiving corticosteroid treatment 6. subjects using oral anticoagulants 7. subjects with a history of soy allergy 8. subjects who have participated in a clinical study more recently than one month before the current study

Keywords: vitamin k vitamin k2 menaquinone-7 osteocalcin adults obesity insulin resistance insulin sensitivity beta-cell function prediabetes
combined resistance and aerobic exercise is better than resistance training alone to improve functional performance of hemodialysis patients - results of a randomized trial

Conditions: End Stage Renal Disease

Summary: this is a randomized trial with participants recruited from one dialysis unit of a brazilian university hospital. hemodialysis patients were assigned to receive the resistance exercise combined with an aerobic training or the resistance training alone for a period of 10 weeks. the functional performance of patients was assessed before and after the intervention through the six-minute walk test (6mwt). the difference over time of the 6mwt was compared between the groups through multivariate linear regression. thirteen patients were allocated for each group of intervention. the difference in distance walked before and after intervention in the combined training group was of +39.7 (61.4) meters, and this difference in the resistance training group was of -19.2 (53.9) meters, p=0.01. in multivariate analysis with adjustment for age, skin color, gender, hematocrit, time since starting dialysis, kt/v and baseline values of 6mwt, the type of training remained significantly associated with the amount of increase in walked distance. although the best protocol of exercise for patients on dialysis is not yet clear, in the investigators sample of hemodialysis patients the combination of aerobic and resistance training was more effective to improve functional performance.


Eligibility criteria:
inclusion criteria: * to be on hemodialysis therapy for longer than 3 months * to be already included in the resistance training protocol during dialysis * to receive erythropoietin for the treatment of anemia * hemoglobin level greater than 9.0 g/dl * to be able to maintain sitting and standing balance and ambulatory without assistance. exclusion criteria: * symptomatic ischemic heart disease * recent myocardial infarction of less than 6 months * uncontrolled hypertension * pericardial or pleural friction rub * aortic stenosis * active musculoskeletal lower-extremity problem, or history of vertebral fracture caused by osteoporosis * patients were also excluded if they participated in formal organized exercise programs outside the dialysis unit.
psychological group treatment in adults with attention deficit hyperactivity disorder: development of a short cognitive -behavioral program

Conditions: ADHD

Summary: attention-deficit/hyperactivity disorder (adhd) is a neurodevelopmental disorder that begins in childhood and can persist throughout adolescence and adulthood. adhd affects persistently about 5% of children and adolescents and about 2.5% of adults worldwide. the cognitive behavioral therapy (cbt) has proven to be effective in significantly reducing adhd-symptoms, maintaining the effects during follow-up. the aim of this study is to develop and validate a psychological treatment program for adult adhd-patients consisting of six sessions based on cognitive behavioural therapy (cbt) and to study the effectiveness of the developed program in short and long term. a total of 90 patients will be randomized to two treatment groups (1:1). one group will receive 12 sessions of cbt and the other group six sessions of brief cbt. it is expected that the short-term effectiveness of a cbt psychological treatment program of six group sessions will be the same as the response to the cbt psychological treatment program of twelve group sessions in adult adhd-patients with stable drug treatment.


Eligibility criteria:
inclusion criteria: * patient with adhd * adhd rating scale\>=24 * cgi\> 3 * stable pharmacological treatment exclusion criteria: * iq\<85 * bipolar dissorder, schizophrenia, psicotic disorders, substance abuse disorder, personality disorders * suicidity ideation * serious organic desease * participate in other psychological treatment during the study
the effect of aspirin desensitization on patients with aspirin-exacerbated respiratory diseases

Conditions: Asthma, Aspirin-Induced

Summary: the purpose of this study is to determine the effect of aspirin desensitization on symptoms and immunologic profile of patients with aspirin-exacerbated respiratory diseases (aerd).


Eligibility criteria:
inclusion criteria: * patients with clinical diagnose of aspirin-exacerbated respiratory disease * history of physician diagnosed asthma. * history of physiacian diagnosed chronic rhinosinositis with nasal polyps. * positive reaction to aspirin challenge test. * stable asthma (post-bronchodilator fev1 of 70% or better, no increase in baseline dose of oral glucocorticoids for at least 3 months, and no history of hospitalization or emergency room visits for asthma for at least the prior 6 months). exclusion criteria: * being smoker * pregnancy * current breastfeeding * history of bleeding diathesis * history of transient ischemic attack or stroke, or diabetes. * history of abnormal hepatic function * uncontrolled hypertension or use of beta blocker medication. * history of gastrointestinal ulcers or gastrointestinal bleeding.

Keywords: aspirin asthma aspirin desensitization aspirin induced asthma immune system diseases respiratory hypersensitivity