Kornimate/medical-research-clean huggingface dataset:
a study to evaluate pregabalin in the treatment of moderate to severe chronic bone pain related to metastatic cancer

Conditions: Bone Neoplasms; Pain, Intractable; Cancer

Summary: the purpose of this study is to assess the analgesic efficacy of flexibly-dosed pregabalin in the adjunctive treatment of subjects with cancer-induced bone pain.

pfizer decided to discontinue additional enrollment into the study effective sept 5 2010 after assessing the feasibility of completing this study in a realistic timeframe.the study was not stopped for any safety concerns.

Eligibility criteria:
inclusion criteria: * patient must have a malignant, solid tumor that has been diagnosed as having metastasized to bone, and must have moderate to severe pain secondary to the bone metastasis at an identifiable reference site. exclusion criteria: * the patient who has undergone diagnostic or therapeutic invasive interventions (angiography, biopsy, surgery) less than 15 days prior to study start that would impact their assessment of pain at the reference pain site or area, in the opinion of the investigator.
osteogenic potential of cissus quadrangularis alveolar ridge distraction

Conditions: Distraction of Bone; Dental Implant

Summary: deficient alveolar mandibular ridge corrected distraction osteogenesis to facilitate dental implant placement. patients grouped into 2 groups: one group received cissus quadrangularis during the consolidation period, and the other group received placebo.

opgs were taken immediately after distractor placement, at end of activation period, at 1st,2nd month of consolidation period, and at end of consolidation period. change in bone height was evaluated immediately after distractor placement, at end of activation and end of consolidation periods. cbct were taken immediately after implant installation, and 6 months later to evaluate change bone density and marginal bone level about the dental implant. histological evaluation was done by biopsy obtained, by trephine bur, from implant site during its preparation. the bone biopsy fixed in 4% formalin solution for 7 days, rinsed in water, and dehydrated in sequent phases of ethanol (70, 80, 90, and 100%) and then specimens were stained by hematoxylin- eosin for microscopic evaluation. radiographic evaluation

Eligibility criteria:
inclusion criteria: * patients were included if they were free from any disease that may affect healing. also, presented with 2-3 missing teeth at least in posterior area and cbct showed bone height above inferior alveolar canal (iac) ranged 8-10mm. exclusion criteria: * patients were excluded if they suffered from any disease affect tissue healing, bad oral hygiene or heavy smoking patients

Keywords: alveolar bone distraction
study comparing the effects of esomeprazole adminstered orally and intravenously on basal and pentrigastrin-stimulated acid output in subjects with symptoms of gastroesophageal reflux disease (gerd)

Conditions: Gastroesophageal Reflux Disease

Summary: the purpose of this study is to examine the effects of nexium at a dose of 40mg administered orally compared to intravenously on the maximum acid output in subjects with symptoms of gastroesophageal reflux disease (gerd).


Eligibility criteria:
inclusion criteria: * heartburn on 2 out of the last 7 days prior to screening or a diagnosis of gerd (with or without a diagnosis of erosive eosphagitis). * body mass index within the limits specified in the protocol exclusion criteria: * history of esophageal, duodenal or gastric surgery * history of severe liver disease. * any other significant disease or pathology judged to be clinically significant by the investigator

Keywords: gastroesophageal reflux disease nexium esomeprazole administration methods.
effect of enhanced external counterpulsation (eecp) on subclinical atherosclerosis

Conditions: Atherosclerosis

Summary: shear stress maybe the most crucial local factor affecting atherogenesis. the present study investigated the effect of exposure to increased shear stress promoted by enhanced external counterpulsation (eecp) on the progression of subclinical atherosclerosis and the underlying inflammation- related molecular mechanisms

hypercholesterolemic subjects with subclinical atherosclerosis will be randomized into two groups: standard treatment group and standard treatment plus eecp intervention group. the results of ultrasound examination and markers of inflammations will be compared.

Eligibility criteria:
inclusion criteria: * 20- 70 years old subjects whose ldl higher than 160mg/dl and carotid intima-media thickness higher than 75 percent of his age. exclusion criteria: * presence of history of coronary heart disease, stroke or atherosclerotic peripheral disease. presence of impaired renal function, connective disease, or infectious disease.

Keywords: atherosclerosis vascular endothelium counterpulsation, external
fluoroscopic vs ultrasound guided sacroiliac (si) joint injection

Conditions: Pain, Chronic

Summary: the investigators aimed to evaluate the effectiveness of intra-articular sacroiliac joint injection under fluoroscopy versus ultrasound guidance


Eligibility criteria:
inclusion criteria: * low back and/or gluteal pain without radicular extension for more than 3 months * tenderness over the si joint * pain score \> 3 by visual analogue scale exclusion criteria: * malignancy * generalized or local infection * coagulopathy * allergy to drugs to be injected
a cross-sectional study of msdx complex 1 as a marker for active disease in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this is a cross-sectional study of msdx complex 1 as a marker for active disease in multiple sclerosis.


Eligibility criteria:
inclusion criteria: 1. age 45 years or older of either gender and of any racial/ethnic group. 2. subjects must be in generally good health. 3. subjects must be able and willing to comply with the requirements of the protocol. 4. must be diagnosed with rrms 5. meets the criteria to enter group 1 or group 2 exclusion criteria: 1. subject is currently in middle of an active episode of an autoimmune condition (e.g. rheumatoid arthritis, system lupus erythematosis) 2. subject currently has a condition such as active influenza that would stimulate the immune system

Keywords: relapsing remitting ms
clinical characteristics and analysis of pituitary complex and rare diseases

Conditions: Pituitary Diseases

Summary: the goal of this observational study is to systematically describe the clinical characteristics and outcomes of patients with pituitary complex and rare diseases at peking union medical college hospital. the main questions it aims to answer are: * what are the influencing factors and rates of remission? * what are the comorbidities associated with these diseases? * what are the perioperative events, radiological findings, and pathological features? researchers will compare different patient groups to see if there are significant differences in these outcomes. participants will: * undergo detailed clinical evaluations. * provide medical history and data for analysis. * participate in follow-up assessments to monitor disease progression and treatment outcomes.

the study aims to provide a comprehensive analysis of pituitary complex and rare diseases at peking union medical college hospital. by leveraging a large cohort, the research will explore various clinical characteristics and outcomes. specifically, the study will examine influencing factors and rates of remission, the presence of comorbidities, and perioperative events. additionally, it will evaluate radiological findings and pathological features to better understand these conditions. through this detailed investigation, the study seeks to enhance knowledge and inform clinical practice regarding the management and prognosis of pituitary complex and rare diseases.

Eligibility criteria:
inclusion criteria: * diagnosed with rare sellar diseases including but not limited to pituitary adenomas (such as thyrotropin-secreting pituitary adenomas, gh-secreting adenomas), craniopharyngiomas, rathke's cleft cysts, sellar region germ cell tumors, cavernous sinus syndrome, and other diseases * detailed medical history, including clinical symptoms, treatment plans and follow-up outcomes exclusion criteria: * incomplete medical records, especially missing key imaging diagnostic results * patients with coexisting primary central nervous system diseases unrelated to sellar region diseases (such as severe traumatic brain injury) * patients whose sellar region pathological diagnosis was changed or overturned during the follow-up period
public health consequences of covid-19

Conditions: COVID-19

Summary: aim of this observational study is to improve our understanding of the impact of covid-19 on health. by an online questionnaire at least 60.000 people are invited by email to participate. invited are those people who tested for covid-19 at the public health service south limburg since june 2020. participants are followed over time (open cohort), to study impact on health, that is physical health, mental health, and social health (longcovid and other conseauences). also, the socioeconomic impact is studied, as on work and education. and the consequences for health-care consumption; it also includes aspects as coping, stigma and lifestyle. all focused to understand the impact of covid-19, in relation to health, and to gain information for promoting positive health and improving prevention and care.

design: prospective observational cohort study mode of study: online questionnaires timing: baseline starting nov. 2021; with regular follow-up measurements measures: a great range of health-associated factors, all self-reported including a range of physical, mental and social health aspects. a range of structural and functional social netwok aspects various measures on covid-19 testing and vaccination various measures on lifestyle behavior. and other measures that are interlinked with health-factors (such as coping, stress, and sociostructural factors) analyses: quantitative data are collected prospectively, and assessed using the appropriate data-analyses methods. thee include for example epidemiological statistical methods, and social network methodology.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * having recieved an online invitation to participate by an email with the study information and questionnaire link, which is send based on the email that was provided to the public health service upon testing for covid-19 at the public health service south limburg exclusion criteria: * none

Keywords: covid-19 longcovid mental health loneliness depression fatigue social health care consumption public health
functional imaging of heterogeneity in head and neck tumors - validation from surgical specimens

Conditions: Squamous Cell Carcinoma of the Head and Neck

Summary: the purpose of this study is to investigate if heterogeneity in head and neck squamous cell carcinoma as seen in functional imaging with pet/mr can be correlated to biologic heterogeneity in surgical specimens.

the following is a presentation of a prospective protocol, named fighht, including patients with squamous cell carcinoma of the head and neck (hnscc) who are referred for surgery. this is a prospective imaging/biomarker expression study where patients referred for surgery for hnscc will be included. the purpose of the study is to investigate if heterogeneity in hnscc as seen in functional imaging with pet/mr can be correlated to biologic heterogeneity in surgical specimens. multiparametric imaging(mpi) is performed before surgery using a pet/mr system (siemens biograph mmr) with a 3 t magnet using a head and neck coil. the scan protocol includes diffusion weighted mri, dynamic contrast enhanced perfusion mri and fdg-pet (4 mbq/kg). morphometric imaging is performed with a 3d t2 weighted sequence (space, voxel size 1.0 mm isotropic in vivo and 0.5 mm isotropic for specimens). the scans are evaluated by a radiologist and a specialist in nuclear medicine and regions of interest and reference areas (anatomical landmarks) are marked. the tumor and if indicated lymp nodes are removed en bloc and per-operatively the reference areas and other anatomical landmarks are marked in the specimen with intravenous tubes. the specimen is fixed to a corkboard and scanned morphometric (as described) using a knee coil before and after formalin fixation within 1 hour after surgery. the whole surgical specimen is sectioned for histological processing. tissue blocks will undergo microscopic pathological evaluation and ihc staining. the specific selection of cancer related ihc biomarkers is based on their relationship with tumor cell metabolism, radiotherapy resistance (proliferation and hypoxia), association with fdg accumulation and institutional experience from a previous study. the quantified measurements from the fdg pet, dwi and dce scan will be correlated to the expression of ihc biomarkers.

Eligibility criteria:
inclusion criteria: * informed consent * age above 18 * primary or recurrent squamous cell carcinoma in the head and neck area * referred to surgery * primary tumor \> 1.5 cm and or neck metastasis of more than 1 cm. exclusion criteria: * patient refusal * contraindications for fdg-pet/mr scan * pacemaker * severe claustrophobia * magnetic metal in the body that is not mr compatible

Keywords: pet/mr squamous cell carcinoma heterogeneity
screen free time with friends: a cluster-randomized controlled trial

Conditions: Time Face to Face With Friends; Screen Media Use

Summary: the screen free time with friends study is a cluster-randomized controlled trial aiming to promote more time face-to-face with friends and reduce recreational screen media use after school and during weekends among children aged 9-11 years. the primary aim is to investigate the between group difference in change in children's time spend face-to-face with peers. secondary aims are to investigate the between group difference in change in children's screen media use, physical activity, wellbeing, social relations, smartphone addiction, sleep and parents smartphone use and risk of smartphone addiction.

during the past fifteen years, children's leisure time spent interacting with friends in person has decreased, while the time they spend engaging with digital screens has increased. these changes in behavior can potentially have adverse effects on both their physical and mental wellbeing. this cluster-randomized controlled trial aims to evaluate an intervention aiming to increase face-to-face interaction with peers and reduce screen media use in 3rd - 4th grade-children. the study is built upon experiences gained from a recently conducted non-randomized single group feasibility trial. the feasibility trial aimed to 1) examine the feasibility of the intervention 2) examine participant recruitment and retention rates, 3) examine the feasibility of the data collection plan and completeness of the compliance and outcome assessment, and 4) obtain baseline and follow-up data on the planned full trial primary outcome. to recruit schools and afterschool clubs for the rct, schools will be contacted directly by a member of the research team or via the municipality. schools and their belonging afterschool clubs are eligible if they meet the following criteria: 1. the school must have an afterschool or youth club (or similar) within walking distance, 2. the afterschool club's leader and staff must be willing to develop the club by participating in a training course. after the baseline measurements the schools and afterschool clubs will be randomized into an intervention and control group. the screen free time with friends intervention is targeted children in 3rd to 4th grade and their families, school- and afterschool club staff, as well as stakeholders in the local community. it comprises an initial gathering for all stakeholders, family workshops held at the school, an exercise during a parent-school meeting, lectures conducted during school hours, a training program for afterschool club staff, and workshops involving local stakeholders. a process evaluation will be conducted to monitor the implementation of the intervention.

Eligibility criteria:
inclusion criteria: * the school must have an afterschool or youth club (or similar) within walking distance * the afterschool club's leader and staff must be willing to develop the club by participating in a training course. exclusion criteria: * no exclusion criteria
cardiogoniometry (cgm) for early diagnosis of acute coronary syndromes (acs)

Conditions: Chest Pain

Summary: aims of the study: patients in a chest pain unit (cpu) are examined to clarify if the cause of pain is cardiac or not. to identify patients with st-elevation and other electrocardiogram (ecg) modifications a normal 12-lead ecg is used. the diagnosis non-st-elevation myocardial infarction is determined with the help of the ischemic marker troponin. however, troponin levels are elevated earliest 3 to 4 hours after the ischemic event, so that a negative troponin result at the time of hospital admission is insufficient. thus the guidelines of the german society of cardiology demand a second measurement after 6 to 12 hours. in rare cases false positive troponin levels have been reported (e.g. in patients with renal insufficiency). the aim of this study is to determine if in the early phase of diagnostic assessment cardiogoniometry can improve differentiation between patients with cardiac (ischemic) emergency and patients with non-cardiac (non-ischemic) cause of pain. furthermore it will be evaluated if cardiogoniometry is capable to diagnose patients with non-st-elevation myocardial infarction (nstemi) to the same extent as troponin. this could avoid time loss until a possibly necessary catheter intervention ("fast track"). to clarify these questions the result of the cardiogoniometry will be compared with the leading diagnosis of the chest pain unit, the diagnosis at hospital discharge as well as with the angiographic findings (as a gold standard). therefore the performance of cardiac catheterization within 72 hours after start of symptoms is a mandatory inclusion criterion.

the cardiogoniometry vectorcardiography is a procedure that allows a stress-free and non-invasive diagnosis of myocardial ischemia: five thoracic electrodes as well as the heart flow in orthogonal summation vectors are recorded by a computer-assisted method in three dimensions.

Eligibility criteria:
inclusion criteria: * age \> 18 years * thoracic pain, or pain radiating to neck or arm, or acute dyspnoea * coronary angiography within 72 hours after start of symptoms exclusion criteria: * st elevation myocardial infarction * hemodynamically unstable patients, provided that the application of cgm may lead to an unacceptable delay in diagnosis and therapy * lack of blood samples for troponin determination at admission * patients with cardiac pacemaker * cardiogenic shock * tachycardia (hr \> 100) * \> 50% extra systoles * branch block * atrial fibrillation * no informed consent

Keywords: cardiogoniometry chest pain unit st-elevation troponin catheter intervention fast track
diagnostic tests in the context of threatened preterm labour

Conditions: Preterm Labor; Immunochromatographic Assay; Predictive Value of Tests; Preterm Delivery; Biomarkers

Summary: the primary purpose of the protocol is to compare the diagnostic accuracy in terms of positive and negative predictive values of premaquick © (combined detection of il-6 / igfbp-1 total / igfbp-1 native) and quikcheck ffn ™ (fibronectin detection) tests for prediction of spontaneous delivery within 7 days in women with threatened preterm labor. the study hypothesis is that combined detection of il-6 / igfbp-1 total / igfbp-1 native dice the admission will improve the prediction of delivery compared to the detection of fetal fibronectin alone in women with threatened preterm labor.

the threat of premature labour is the main cause of hospitalization during pregnancy (38% of hospitalizations). to date, the assessment of severity relies mainly on ultrasound measurement of the cervix. the length of the cervix is significantly correlated with the risk of spontaneous premature delivery. a threshold of 25mm is relevant to rule out a delivery within 7 days but the identification of new markers including biological would be interesting to guide the clinician in assessing the risk of preterm birth. among the biomarkers measured in vaginal secretions, the detection of fetal fibronectin seems to be the most relevant because of a high negative predictive value (npv) up to 100% to rule out a delivery within 7 days. however, the use of this test is discussed because of its low positive predictive value (ppv) to predict delivery within 7 days (from 11% to 48%). the use of premaquick © test (biosynex, strasbourg, france), which allow the simultaneous quantification of il-6, total igfbp-1 and native igfbp-1 could be more efficient compared to the detection of fibronectin by improving the vpp. the results already obtained on a cohort of 97 patients (eleje et al., 2016) show a similar npv and a higher ppv of the premaquick© test compared to the quikcheck ffn ™ test (ppv up to 95% when the 3 markers are positive). investigator wish to conduct a comparative study between these two tests on a larger cohort of patients (n = 220). results of the tests will be masked for the clinician and the patient in order to assess and compare their ability to predict delivery within 7 days without modify the current medical management.

Eligibility criteria:
inclusion criteria: * major pregnant women admitted to clermont-ferrand chu maternity for threatened preterm delivery with intact membranes between 24 and 34 (+6 days) week of amenorrhea, with length of cervix \< 30mm (ultrasound measurement). * ability to give informed consent. * french social security scheme. exclusion criteria: * - dilation of the cervix ≥ 4 cm * triple pregnancy or more * fetal membranes rupture * known uterine malformation * hydramnios * fetal malformation * placenta previa * abundant metrorrhagia * patient who had already participated in the study during the same pregnancy * patient under guardianship or curatorship

Keywords: preterm labor biomarkers preterm delivery threat
robot assisted radical prostatecomy and positional injury

Conditions: Peripheral Nerve Injuries

Summary: although a condition for surgery, robotic interventions applied with steep trendelenburg-lithotomy (st-l) position may cause positional injury and peripheral neuropathy if good position is not achieved on the operating table. this study will be a 7-year retrospective examination of postoperative positional injury (ppi) in patients undergoing robot-assisted radical prostatectomy (rarp) for prostate diagnosis.

patients who underwent rarp between 2008-2014 will be evaluate. patients with known peripheral neuropathy, lumbar-cervical discopathy, or history of orthopaedic surgery or trauma will exclude. the demographic data of patients, asa, charlson comorbidity index (cmi), body mass index (bmi), operating time (ot) and trendelenburg time (tt) will obtain from patient records. patients will be questioned as to whether or not ppi had developed, if so, in which extremity, in what form (sensory-motor), duration, whether or not a doctor had been consulted, if so, what treatment had been given and whether or not the ppi had continued.

Eligibility criteria:
inclusion criteria: * patients undergoing robot-assisted radical prostatectomy (rarp) for prostate diagnosis. exclusion criteria: * patients with known peripheral neuropathy, * lumbar-cervical discopathy, * history of orthopaedic surgery or * trauma were excluded

Keywords: robotic surgical procedures trendelenburg position