Kornimate/medical-research-clean huggingface dataset:
endometrial compaction in assissted reproduction

Conditions: Infertility, Female

Summary: to record the dynamic change of endometrial thickness (day of embryo transfer versus. day of ovulation trigger administration in case of fresh cycles or end of estrogen phase in frozen cycles), and to investigate the impact of endometrial thickness change on pregnancy outcomes

clinical pregnancy rate in ivf cycles depends on embryo quality and endometrial receptivity . it is challenging to assess endometrial receptivity. measuring endometrial thickness by ultrasonography is a simple , noninvasive and accurate method to do so. many studies have implicated endometrial thickness and pattern as prognostic parameters for successful outcomes in ivf-et. some studies have suggested a minimal thickness for a successful pregnancy to occur, while others have reported adverse effects of increased endometrial thickness above which pregnancy is unlikely to occur. now there is a novel hypothesis that not only the initial endometrial thickness can affect implantation rate and clinical pregnancy rate ,but also the decrease in endometrial thickness in the time interval between the ovulation triggering and the embryo transfer or what is called endometrial compaction increases the implantation and clinical pregnancy rate

Eligibility criteria:
inclusion criteria: * • infertile women aged 18 years to 40 years undergoing ivf/ icsi for any indication. exclusion criteria: * • history of recurrent pregnancy loss (≥ 2 spontaneous abortions) and/or history of recurrent (≥ 2) icsi failure after embryo transfer. * uterine malformations. * uncorrected hydrosalpinx. * intrauterine conditions affecting pregnancy outcomes such as ( intrauterine adhesions, fibroids, polyps). * any previous hysteroscopic surgery eg. metroplasty or hysteroscopic myomectomy or uterine surgeries involving the endometrium eg. myomectomy during which uterine cavity was opened. * history suggesting endometritis. * use of hcg for endometrial preparation or luteal phase support. * poor quality embryos( according to istanbul consensus workshop on embryo assessment )

Keywords: infertility ivf , icsi endometrium compaction
evaluating the safety of myfortic (mycophenolate sodium) in patients with lupus nephritis

Conditions: Lupus Nephritis

Summary: this is an open-label, prospective, single-arm, observational study in patients with lupus nephritis (ln) who newly (i.e.,for the first time) received treatment of enteric-coated mycophenolate sodium (ec-mps).

this is an observational study. patients will be treated and followed according to routine medical practice in terms of visit frequency and type of assessment performed. only endpoint related data will be collected as part of the study. patient demographic information, disease characteristics, treatments and laboratory data will be collected retrospectively.

Eligibility criteria:
inclusion criteria: 1. aged ≥ 20 years and ≤ 75 years at screening. 2. patients with written informed consent form. 3. male or female diagnosed with sle. 4. confirmed diagnosis of ln by physician. diagnosis of ln is defined as: a. kidney biopsy within 1 year, with histological diagnosis of ln (class iii/iv/v) 5. laboratory evidence of active nephritis: spot upcr\>0.5, and/or proteinuria \> 0.5 g/24 hours, and/or greater than 3+ by dipstick, and/or cellular casts. 6. patients with ln who received ec-mps for the first time. the patients who switched from other treatment and treatment naive patients (did not received any treatment before) can be included in this study. 7. women of childbearing potential must use effective contraception before beginning ec mps therapy, during therapy, and for six weeks after their last dose of ec mps. exclusion criteria: 1. previous or planned kidney transplant. 2. currently receiving continuous dialysis or gfr \< 30 ml/min/1.73 m2 within 3 months prior to the start of study. 3. patients with active serious digestive system disease, including infrequent cases of gastrointestinal tract ulceration with hemorrhage or perforation. 4. patients currently with life threatening conditions including malignancies, or severe infection in recent 6 months prior to start of study

Keywords: lupus nephritis ln myfortic mycophenolate sodium
use of donepezil for treatment of cocaine dependence

Conditions: Cocaine Abuse and Dependence

Summary: the purpose of this study is to determine the safety of intravenous cocaine in subjects receiving oral donepezil.

this is a randomized, double-blind, double-dummy, placebo controlled, inpatient, single-center, parallel group evaluation of the potential for oral donepezil to attenuate cocaine-induced craving. non-treatment-seeking cocaine-experienced volunteers will receive baseline treatment with intravenous cocaine (30mg). forty-two subjects that tolerate baseline cocaine infusions will then receive two subsequent intravenous doses of cocaine during double-blind treatment with oral placebo or 5 mg daily of donepezil. each dose of cocaine will be preceded or followed by administration of intravenous placebo (saline) in a random order.

Eligibility criteria:
inclusion criteria: * non-treatment seeking, experienced cocaine users, who have used cocaine by smoking or intravenous injection within the four weeks prior to screening, and must supply a cocaine-positive urine obtained within four weeks of entry into the study. exclusion criteria: * shows signs of psychostimulant toxicity, or has a history of a medical adverse reaction to cocaine or other psychostimulants, including loss of consciousness, chest pain, cardiac ischemia, or seizure. * has a current psychiatric disorder other than drug abuse or dependence or dementia. * meets the diagnostic and statistical manual of mental disorders-iv criteria for dependence to opiates, benzodiazepines, alcohol, or other sedative-hypnotics. * has received opiate-substitution therapy (methadone or buprenorphine) within two months prior to enrollment. * has current or past history of seizure disorder, including alcohol- or psychostimulant- related seizures, or family history of seizure disorder. * has a diagnosis of adult asthma, or chronic obstructive pulmonary disease, including a history of acute asthma within the past two years, and those with current or recent (with the past two years) treatment with an inhaled or oral beta-adrenergic agonist. * has had head trauma that resulted in neurological sequelae. * has an unstable medical condition, which, in the judgement of investigators, would make participation hazardous.

Keywords: acetylcholine acetylcholinesterase butyrylcholinesterase cholinesterase inhibitor
factors and consequences associated with diabetic foot problems among diabetic patients in jordan

Conditions: Diabetic Foot

Summary: purpose: to assess diabetic foot ulcers (dfu)-related risk factors and complications among diabetes mellitus (dm) patients in northern jordan. also, to analyze the impact of educational intervention on their behavior. methods: the study consisted of two phases. phase one was a prospective cross-sectional study of 200 dm patients, including 94 with a history of dfu, where demographic and clinical data were collected to assess diabetic foot-associated risk factors and complications. phase two was a randomized clinical trial with 105 dm patients: 52 in the control group received standard care, while 53 in the intervention group received standard care supplemented with formal educational session and ongoing foot care education via mobile health by a clinical pharmacist. foot care practices and medication adherence were evaluated at baseline and after 8 weeks of follow-up.

background: diabetes mellitus (dm) is a common chronic metabolic condition with numerous consequences, including diabetic foot ulcers. diabetic foot ulcer (dfu) is the major cause of non-traumatic lower extremity amputations. dfu is linked to several risk factors, including a lack of information and inadequate foot care practices. in jordan, statistics on diabetic foot are few, with no evidence of the impact of patient education on disease outcomes. aims: to assess dfu-related risk factors and complications among dm patients in northern jordan. also, analyze the impact of educational intervention on their behavior. methods: a prospective cross-sectional sample of 200 dm patients, including 94 with a history of dfu was initially selected. subsequently, a smaller cohort of 105 patients was randomized into either a control group or an intervention group after providing written informed consent. the control group received standard care, while the intervention group received standard care supplemented with formal educational session followed by ongoing education on foot care using mobile health by a clinical pharmacist. diabetic foot-associated risk factors and complications were assessed. foot care practices and medication adherence were evaluated for both the control and intervention groups at baseline and again after 8 weeks of follow-up. binary logistic regression was employed to assess factors associated with dfu. the chi-square test and independent sample t-test were used to compare the behavior between the two groups before and after the intervention.

Eligibility criteria:
inclusion criteria: * adults dm (1 year) have a mobile phone exclusion criteria: * cognitive impairment
culturally adapted manual-assisted problem solving training based mobile intervention

Conditions: Suicidal Ideation

Summary: determine the feasibility, acceptability and efficacy of an adapted digitally delivered cmap (cmap-si) intervention (cami) compared to treatment as usual (tau) for patients presenting with suicidal ideation.

the reported suicide rates in south asia are high compared to the global average. these figures are likely to be an underestimate since suicide data from many lmics such as pakistan is lacking and what is available is not reliable (jordans et al., 2014). according to an estimate, 5,000 to 7,000 suicides take place each year in pakistan (hafeez, 2016) and at least 10 to 20 suicide attempts happen for every suicide. mobile health is a novel and emerging field in psychiatric and psychological care and treatment of mental health difficulties, it involves the use of telecommunications to provide health care, support and intervention from a distance. the proposed study will be carried out in two phases; stage 1) adaptation of an already existing culturally adapted manual assisted problem solving intervention (cmap) for patients with suicidal ideation presenting to primary care in pakistan and further adaptation into a digital intervention. stage 2) feasibility randomised control trial.

Eligibility criteria:
inclusion criteria: individuals (aged 18-64) screened and identified as having suicidal ideation * able to give written informed consent * living within the catchment areas of participating hospitals * have a smart phone and able to operate it * able to read and speak urdu * not requiring in-patient psychiatric treatment. exclusion criteria: * presence of a diagnosed physical or intellectual disability as it can prevent individuals from engaging with the intervention. this will be assessed by the research team at screening stage. any disabilities will be identified by a relevant clinician (e.g. psychiatrist). * temporary resident unlikely to be available for follow-up (b) participants with a diagnosis of dsm-iv mental disorder due to general medical condition or substance misuse, dementia, delirium, alcohol and drug dependence, schizophrenia, or bipolar disorder.

Keywords: self-harm suicidal ideation mobile intervention cultural adaptation pakistan lmic problem-solving cbt
enhancing transdiagnostic mechanisms of cognitive dyscontrol

Conditions: Anxiety Disorders; Depression; Posttraumatic Stress Disorder

Summary: the proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. participants will be randomly assigned to a high dose, low dose, or assessment only condition. participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

mood, anxiety, and traumatic stress disorders are common psychiatric conditions - affecting over 40 million u.s. adults - and are leading causes of disability worldwide. people with these conditions are commonly plagued by difficulty controlling distressing personal thoughts and memories, collectively referred to as repetitive negative thinking symptoms. models suggest that repetitive negative thinking is driven by executive functioning deficits, such that cognitive resources are insufficient to downregulate unwanted thoughts. executive functioning deficits could be a promising treatment target but are not typically addressed with existing interventions. the long-term goal advanced by this project is to develop effective, mechanistic cognitive training programs that can improve cognition and reduce symptoms associated with mood, anxiety, and traumatic stress disorders. the objectives of this proposal are first to determine the optimal dose of a cognitive training program designed to improve executive functioning in this population using behavioral and neural outcomes. the central hypothesis is that repeated training exercises will enhance executive functioning and will lead to a reduction of repetitive negative thinking in mood, anxiety, and traumatic stress disorders. the project will randomize participants with depression, anxiety, and/or traumatic stress disorders to one of two doses of cognitive training or a no-treatment control condition. the investigators will examine executive functioning change with cognitive task performance and functional neuroimaging assessments.

Eligibility criteria:
inclusion criteria: * age 21-55 * fluent in english * diagnosis of mood, anxiety, or traumatic stress disorder * clinically elevated repetitive negative thinking * outpatient status * 6-week stability if taking selective serotonin reuptake inhibitor (ssri) medications exclusion criteria: * past year diagnosis of severe alcohol or moderate or greater substance use disorder * lifetime history of psychotic or bipolar i disorder * acute suicidality necessitating immediate clinical intervention * neurodegenerative or neurodevelopmental disorders * history of moderate or severe traumatic brain injury or other known neurological condition * sensory deficits that would preclude completing tasks * conditions unsafe for completing mri scanning (e.g., metal in body) * currently receiving psychosocial treatment * currently receiving psychiatric pharmacotherapy, except ssris
effectiveness of fissure sealants bonded with different universal adhesives

Conditions: Dental Caries on Pit and Fissure Surface

Summary: the purpose of this study is to evaluate and compare the clinical retention of a resin-based fissure sealant placed with prior application of etch-and-rinse and self-etch modes of universal adhesives.

sealants will placed on previously unsealed, caries-free permanent first molars, employing a split-mouth design. 100 patients will be included the study. the teeth will be randomized into eight groups according to the adhesive systems and modes placed under the tested resin-based sealant. group1: acid-etch + fissure sealant (clinpro 3m espe, u.s.) (control arm) group2: all bond universal (bisco inc., schaumburg,il, u.s.) - with self etch technique + fissure sealant ; group3: all bond universal - total etch technique + fissure sealant group4: scotchbond (single bond) universal (3m espe, u.s.) - self etch technique + fissure sealant group5: scotchbond (single bond) universal - total etch technique + fissure sealant group6: clearfil universal bond (kuraray, tokyo, japan) - self etch technique + fissure sealant group7: clearfil universal bond- total etch technique + fissure sealant group8: single bond plus (3m espe)- total etch technique + fissure sealant clinical assessments will be performed according to modified usphs criteria at 3, 6, 12, 18 and 24 months. retention, seconder caries, marginal adaptation and marginal discoloration of the sealants will be evaluated. the data will be analyzed statistically using fisher's exact test and kaplan-meier analysis.

Eligibility criteria:
inclusion criteria: * teeth having clinical indication of sealing with pit and fissure sealant. * patients with four fully-erupted permanent molars, with unstained, caries-free and unsealed pit and fissures. exclusion criteria: * patients having incipient carious lesions, fewer erupted molars or teeth without pits on buccal/palatal surfaces. * patients with systemic diseases.

Keywords: universal adhesive fissure sealants retention
aripiprazole used as dual therapy in the treatement of patients with chronic stable schizophrenia or schizoaffective disorder.

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: a multicenter, double-blind 16 week study on the augmentation of atypical antipsychotic with aripiprazole in patients with schizophrenia with inadequate response to antipsychotic treatment.


Eligibility criteria:
inclusion criteria: * patient with diagnosis of chronic schizophrenia or schizoaffective disorder * stable symptoms and dose of quetiapine or risperidone exclusion criteria: * first diagnosis in the past year * significant risk of suicide or meet dsm-iv-tr criteria for substance abuse
the role of statins in the prevention of contrast-induced acute kidney injury in patients with cardiovascular diseases

Conditions: Contrast-induced Acute Kidney Injury; Cardiovascular Diseases

Summary: the aim of the study is to assess the role of statins and different dosage regimens in the prevention of contrast-induced acute kidney injury in patients with cardiovascular diseases requiring intravenous contrast media administration before computer tomography


Eligibility criteria:
inclusion criteria: * written informed consent * indications for computer tomography with intravenous contrast media administration * cardiovascular diseases (arterial hypertension, arrhythmia etc) exclusion criteria: * pregnancy * statin therapy before inclusion in the study * acute coronary syndromes * contraindications for statins administration * patients with chronic kidney disease stages 4-5 * contraindications for computer tomography with contrast media administration * nephrotoxic drugs use (nsaids, vancomycin etc)

Keywords: contrast-induced acute kidney injury contrast-associated acute kidney injury contrast media cardiovascular diseases computer tomography
neurologic manifestations of covid 19 in children

Conditions: COVID; Neurologic Manifestations

Summary: the purpose of this study is to perform a secondary analysis of pre-existing de-identified limited datasets obtained from sites participating in tier 1 (study20040154: neurologic manifestations of covid 19 in children) and tier 2 (study20040278: neuro covid - outcomes). the data will be used to determine the prevalence and severity of neurological symptoms among patients requiring critical care admission for confirmed or suspected novel coronavirus (covid-19) and to determine the predictors for limitation of care in the study population, as well as, the prognosis of neurologically injured patients admitted to the icu during the covid-19 crisis. this study is sponsored by the pediatric neurocritical care research group (pncrg) and sponsored and funded in part by the neurocritical care society.

early reports of covid-19 indicate that adults experience a variety of neurological symptoms and diagnoses in approximately 36% of patients, including headaches, seizures, coma, encephalitis, and cerebrovascular events including ischemic stroke, intracranial hemorrhage, and cerebral venous sinus thromboses. in children, recent evidence highlights acute and long-term neurological manifestations due to other viral illnesses including guillain barre syndrome and neonatal microcephaly with zika virus, encephalitis with h1n1 influenza, and acute flaccid paralysis with enterovirus-68. however, covid-19 reports in children published thus far lack detailed information on the frequency and outcomes of neurological findings. covid-19 cases are rapidly rising internationally, with experts forecasting subsequent global surges and continued activity. thus, it is imperative to accurately document prevalence and outcomes of the neurological aspects of covid-19 specifically in children. such data will serve to alert clinicians and families about the possibility that children may present with neurologic rather than "classic" symptoms of covid-19 who nevertheless would warrant testing, and that neurologic events can occur subsequent to the diagnosis that may impact long-term outcomes (e.g., cognitive, emotional, physical health). the investigators anticipate that improved knowledge about neurologic manifestations in children will bolster personalized treatment and rehabilitation strategies to optimize child outcomes and inform future interventional studies.

Eligibility criteria:
inclusion criteria: * infants, children, and young adults age \< 18 years * admitted to the hospital with confirmed or presumed covid-19 infection (includes admissions to emergency, ward, intensive care etc.) exclusion criteria: * none

Keywords: child neurocritical care covid-19 neurologic manifestations
mobile health application for diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: creation of a mobile health application for individuals with type ii diabetes. this application was designed to improve knowledge, self-efficacy and self-care. the application delivered educational material and provided push notifications (messages). it also allowed for the participants to key in blood glucose levels, carbohydrate consumption and daily exercise.

capability (the mobile health application) was designed to cover three main diabetes content areas which the investigators call modules: diet (module 1), exercise (module 2) and self-management (module 3) (i.e. medication adherence, glucose monitoring). the length of the study was 9 weeks in duration with three weeks of content per module. within each module new material was delivered each week through capability. essentially, every monday started a new week's worth of educational material that was intended to last until sunday. each participant was randomly assigned to either the control group (no triggers), spark trigger group or facilitator trigger group. at the beginning of each module the participants would be randomly assigned to one of the three aforementioned classification groups (this was a 2-factor cross-over design). the investigators utilized the perceived diabetes self-efficacy scale , diabetes knowledge test developed by michigan university, and the summary of diabetes self-care activities measures scale (sdsca) . all the participants completed the perceived diabetes self-efficacy scale along with the knowledge test and sdsca pre/post intervention. in addition, the participants answered one self-efficacy, knowledge, self-care and goal question at the conclusion of each week within capability.

Eligibility criteria:
inclusion criteria: * must be at least 21 years of age or older * current diagnosis of type ii diabetes * must have access to a smartphone and daily internet (wifi) exclusion criteria: * anyone with gestational diabetes