Kornimate/medical-research-clean huggingface dataset:
absorbable vs non-absorbable sutures for hip capsular closure

Conditions: Labrum Injury of the Hip Joint; Hip Arthroscopy; Femoroacetabular Impingement Syndrome

Summary: the study is to prospectively compare absorbable sutures with non-absorbable sutures used for capsular repair during hip arthroscopic procedures. major outcomes will be measured using three questionnaires ((1) international hip outcome tool-12 (ihot-12), (2) modified harris hip score, (3) hip outcome score) in addition to the standard of care set of 9 questionnaires. the other major outcome will be any radiographic heterotrophic ossification at the 6-month follow-up time point.

1. international hip outcome tool-12 is a 33-item patient-reported measure of health-related quality of life. it was designed to measure the impact of hip disease in young, active patients and to measure the effect of treatment of this disease. 2. modified harris hip score is composed of 8 survey questions to determine gait, functionality and pain. 3. the hip outcome score is 26 survey questions designed to asses the outcome of arthroscopic hip surgery for individuals with acetabular labral tears, including sports related questions and activities of daily living. standard of care questionnaires will be given at follow up clinic visits. they are the: 1. patient reported outcomes measurement information system (promis) physical function 2. promis pain interference 3. promis global health 4. pain visual analog scale 5. hip single assessment numeric evaluation (sane) 6. modified harris hip score 7. marx activity scale 8. tegner activity scale 9. surgical satisfaction these questionnaires will be given at preoperative, 6-week, 3-month, 6-month, 1 year, 2 years and any other follow-up visits in association with surgery. any radiographic images taken as standard of care (soc) (post-operative radiographs are soc) will be used in the study to determine radiographic heterotroph ossification (ho) at 6 months.

Eligibility criteria:
inclusion criteria: * subjects 18 years of age and older. * subject requiring surgical hip arthroscopic intervention for their hip pathology exclusion criteria: * subjects less than 18 years of age. * subjects with any other medical problem precluding anesthesia or surgery. * unable to provide informed consent.
impact on cognitive function and quality of life of adjuvant chemotherapy in patients aged over 65 years: application to breast cancer or colon

Conditions: Breast Cancer

Summary: the aim of the study is to investigate the impact of adjuvant chemotherapy on cognitive function in patients aged over 65 and suffering from breast cancer or colon.


Eligibility criteria:
inclusion criteria for patients with chemotherapy : * patient(e) aged over 65 years * non metastatic breast cancer * adjuvant chemotherapy breast cancer: fec, including docetaxel protocols * no major cognitive impairment * lack of personality disorders and psychiatric disorders evolutionary * having signed the informed consent of study participation inclusion criteria for patients without chemotherapy (control group): * patient(e) aged over 65 years * breast cancer * patients receiving no adjuvant chemotherapy * no major cognitive impairment * lack of personality disorders and psychiatric disorders evolutionary * having signed the informed consent of study participation * matching on age, sex, cultural level and tumor location exclusion criteria for patients with chemotherapy : * metastatic * cancer primitive other than breast * patients under 65 years * patients with adjuvant chemotherapy is associated with targeted therapy * patients who have received other cancer treatments (chemotherapy or radiotherapy brain) * disorders of higher functions existing in the administration of chemotherapy * pathology psychiatric evolutionary * refusal of participation * patients unable to meet the cognitive tests * drug use * heavy drinking

Keywords: cognitive functions quality of life breast cancer chemotherapy ages patients
effects of different inspiratory muscle training protocols in patients with chronic kidney disease

Conditions: Chronic Kidney Diseases; Inspiratory Muscle Training; Exercise Capacity

Summary: the goal of this study is to investigate the effects of different imt protocols on respiratory muscle strength, functional exercise capacity, quadriceps femoris muscle strength (qms), handgrip muscle strength (hgs), qol, respiratory function, dyspnoea, fatigue, balance, and pa levels in patients with ckd that were not on dialysis.

peripheral and respiratory muscle weakness has been reported in patients with chronic kidney disease (ckd). management of respiratory muscle weakness is crucial, as reduced functional performance is related to respiratory muscle weakness. different imt function protocols with 30-70% of the maximal inspiratory pressure (mip) have been found to improve these in patients with ckd. the most efficient imt intensity for patients with ckd is unknown. therefore, this study aims to investigate the effects of different imt protocols on respiratory muscle strength, functional exercise capacity, quadriceps femoris muscle strength (qms), handgrip muscle strength (hgs), qol, respiratory function, dyspnoea, fatigue, balance, and pa levels in patients with ckd that were not on dialysis.

Eligibility criteria:
inclusion criteria: * patients with ckd stages 1-5 based on the ckd staging proposed by the kidney disease outcomes quality initiative who are not on dialysis * aged\>18 years * no change in medications over one month exclusion criteria: * uncontrolled hypertension * non-stable cardiac disease * recent viral infections * respiratory, neurological, and orthopedic diseases * pregnant and lactating patients

Keywords: chronic kidney disease inspiratory muscle training
short-course out-patient pulmonary rehabilitation and copd exacerbations

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study assessed whether a short course pulmonary rehabilitation programme with periodic reinforcement exercise training and phone call reminders would help to increase physical activity in copd patients and also decrease readmissions for aecopd.

objectives: chronic obstructive pulmonary disease (copd) is a disease with significant morbidity and incurs heavy utilization of healthcare resources. the direct cost of hospital admissions related to copd is the single largest source of expenditure in the public hospital system. this study assessed whether a short course pulmonary rehabilitation programme with periodic reinforcement exercise training and phone call reminders would help to increase physical activity in copd patients and also decrease readmissions for aecopd. hypothesis: the above programme can reduce readmissions for aecopd design: randomised control trial. patients will be randomised to the intervention or usual care group subjects: patients discharged from hospital after an episode of acute exacerbation of copd study instruments: activity monitor, quality of life questionnaire interventions: the intervention group will receive a short course pulmonary rehabilitation training as out-patient in the physiotherapy department for 4-8 sessions, 2 hours each time, 1-2 times weekly. the training is scheduled in the way that each subject would have at least 4-8 weeks supervised training by trained physiotherapist. home exercise will be taught and the case manager will give phone calls to the subject every 2 weeks to provide support and reinforcement for having continuous exercise at home for one year. patients will be invited to attend reinforcement out-patient physiotherapy training once very month or every 2 months if they are willing to attend.

Eligibility criteria:
inclusion criteria: * patients with copd exacerbations exclusion criteria: 1. history of asthma, lung resection or other significant pulmonary disease like pulmonary fibrosis. 2. active infection like pulmonary tuberculosis 3. unable to complete assessment due to physical and/or cognitive impairment 4. completed a pulmonary rehabilitation program in the previous 24 months. 5. having short life expectancy like subjects with terminal malignancy or intractable heart failure
evaluation of the boks before-school physical activity program

Conditions: Overweight and Obesity; Affect; Physical Activity; Fitness

Summary: boks, build our kids' success, is a before-school physical activity program that has been implemented in over 2,000 elementary and middle schools. students participate in the program for 12 weeks, two or three mornings per week for about 1 hour per session. this study if a non-randomized control trial seeking to 1) examine the extent to which participation in the before-school boks program improves, health, well-being, and performance, and 2) compare the results of a two-day-per-week versus a three-day-per-week program.


Eligibility criteria:
inclusion criteria: * participating school * child age 5-14 years exclusion criteria: * no valid parental consent * missing group assignment

Keywords: overweight obesity school physical activity
diabetes outcomes in covid-19 pandemic

Conditions: Diabetes; Covid19; Isolation, Social

Summary: diabetes management and follow-up has become a challenge during the covid-19 pandemic. nation-wide lockdowns and social distancing measures adopted in an attempt to break the chain of covid-19 transmission have significantly disrupted routine care and follow-up of diabetes. in the health sector, especially in low-income countries such as pakistan, there has been a shift of resources and staff reassignment from stable chronic illnesses to support covid-19 pandemic. disruption of routine outpatient health services and travel restrictions increase the risk of worsening diabetes control and diabetes-related health outcomes. additionally, social isolation amidst an atmosphere of fear and uncertainty contributes to stress further affecting glycaemic control.

an observational cross-sectional study was conducted using telephone interview method in diabetes management centre (dmc), services hospital, lahore. the study participants were 1282 diabetic patients selected randomly from electronic medical record (emr) database of the centre. a structured questionnaire was used to evaluate parameters which included patients' demographic information; diabetes self-care and general health profile; covid-related questions and its impact on quality of life (qol); financial and social support issues.

Eligibility criteria:
inclusion criteria: * type 1 and type 2 diabetic patients registered with diabetes management centre, services hospital, lahore, pakistan. exclusion criteria: * patients lacking telephonic contact or with invalid contact numbers.

Keywords: covid-19 diabetes mellitus telesurvey
evaluation of the abbott i-stat tbi biomarker test

Conditions: Traumatic Brain Injury

Summary: according to the centers for disease control and prevention, approximately 200,000 hospitalizations occurred in 2020 related to traumatic brain injury (tbi), which does not include many tbis treated only in emergency departments, urgent care, primary care, or that are not evaluated by a clinician. head ct is a critical component of care for severe tbi, however in mild tbi there is practice variation with a wider risk to benefit estimation for obtaining head ct imaging. potential disadvantages of head ct include longer emergency department (ed) length of stay (los), higher costs, and diagnostic radiation exposure. the i-stat tbi test is a panel of in vitro diagnostic immunoassays for the quantitative measurements of glial fibrillary acidic protein (gfap) and ubiquitin carboxyl-terminal hydrolase l1 (uch-l1) in whole blood and a semi-quantitative interpretation of test results derived from these measurements, using the i-stat alinity instrument. this biomarker test is cleared for use in adults with mild tbi (glasgow coma scale 13-15) within 24 hours of injury, to aid in determining the need for head ct imaging. currently, ct head imaging for adults with suspected mild tbi is obtained based on clinicians' usual practice patterns and beliefs about patient expectations. prior research has demonstrated the blood tbi test may reduce unnecessary ct scans by up to 40%, however the impact on head ct ordering has not yet been studied prospectively. it is important to understand the extent to which a negative tbi biomarker result empowers a clinician to cancel a previously ordered head ct. given that adult patients with mild tbi often present to eds, which have access to ct scanners, this is a key setting to assess real-world impact of the i-stat tbi test on ct head utilization.


Eligibility criteria:
inclusion criteria: * age ≥18 years * head injury within 24 hours of research blood collection * ct head ordered as part of routine care, not yet completed. * glasgow coma scale (gcs) 13 - 15 exclusion criteria: * unknown whether head injury occurred, and signs of head injury are absent * previously enrolled in this study in the past 30 days * prisoner or in police custody or known pregnancy * suspected current ischemic or hemorrhagic stroke * suspected open or depressed skull fracture, or signs of skull base fracture * history of multiple sclerosis * venipuncture not feasible

Keywords: point of care testing emergency care clinical decision making head injury
open-label single-arm pilot study in adult allogeneic hematopoietic stem cell transplant recipients with transfusional iron overload

Conditions: Iron Overload

Summary: this study has been designed to establish the efficacy and safety of deferasirox in patients with iron overload from 6 to 18 months after allogeneic hematopoietic stem cell transplant (hsct). the purpose of this study is to assess the mean change in serum ferritin after 52 weeks of treatment with deferasirox, in patients with iron overload (defined with serum ferritin levels ≥ 1000 ng/ml and receiving \> 20 rbc concentrates) after allogeneic hsct.


Eligibility criteria:
inclusion criteria: * male or female patients 18 years of age and older * patients to undergo allogeneic hsct between 6 and 18 months prior to inclusion. * patients with screening anc \> 1000/mm3 and ferritin values ≥ 1000 ng/ml (ferritin values must be measured in two measurements at one-week intervals). * patients receiving at least 20 rbc concentrate units or 100ml/kg rbc during their lives. * patients giving their informed consent (prior to performing any study procedure) exclusion criteria: * haemosiderosis not related to transfusion. * patients with concomitant active malignancy. * active known viral hepatitis or known hiv-positive. * mean levels of alanine aminotransferase (alt) \> 5x uln * treatment with any iron chelating agent after allogeneic hsct. * uncontrolled hypertension. other protocol-defined inclusion/exclusion criteria may app

Keywords: iron metabolism, allogenetic hematopoietic stem cell transplant, haematological diseases
multi-center observational study to evaluate epidemiology and resistance patterns of common icu-infections (moser)

Conditions: Nosocomial Infections

Summary: most literature on icu infections and the resistant patterns comes from the western literature. this data may not truly reflect the incidence, epidemiology and resistance patterns in developing countries such as india. however, empiric antibiotic therapy is generally initiated using western guidelines. this can potentially lead to inadequate, inappropriate and ineffective empiric antibiotic therapy for icu infections in the indian setting. hence in this multi-center observational study, we seek to: 1. to determine the incidence of icu-related infections (vap, cauti and crbsi) in india 2. to explore the microbiology, resistance and treatment patterns of these infections


Eligibility criteria:
inclusion criteria: 1. icu stay \>48 hours 2. one of the following infections (vap, cauti or crbsi) exclusion criteria: 1. index icu stay \< 48 hours 2. re-admissions to the icu within the same hospitalization 3. age \>18 years or \<70 years 4. known hiv serology positivity 5. burns 6. solid organ or bone-marrow transplant 7. no icu-acquired infections (specifically vap, cauti and crbsi)

Keywords: ventilator associated pneumonia catheter related blood stream infection catheter associated urinary tract infection icu-related infections (vap, cauti and crbsi) india
efficacy and safety of sox regimen combined with camrelizumab as neoadjuvant treatment in locally advanced gastric cancer: a phase ii, single-arm study

Conditions: Stomach Neoplasms; Digestive System Neoplasms; Neoplasms; Digestive System Diseases; Stomach Diseases; Neoplasms by Site

Summary: this is a single-arm, phase ii study of camrelizumab combined with sox regimen in subjects with resectable locally advanced gastric cancer. the patients will receive camrelizumab ,s-1 and oxaliplatin given every 3 weeks for 3 cycles as neoadjuvant therapy. after the surgery, adjuvant therapy which includes camrelizumab and sox regimen will begin.


Eligibility criteria:
inclusion criteria: 1. age older than 18 years of age; 2. histologically or cytological confirmed gastric or gastroesophageal junction adenocarcinoma; 3. without prior systematic therapy; 4. the eastern cooperative oncology group performance status (ecog ps) 0-1; 5. with measurable lesions according to response evaluation criteria in solid tumors (recist) 1.1; 6. clinically diagnosed stage ct3-4bn1-3m0 evaluated by ct/mri/eus; 7. life expectancy longer than 12 months; 8. adequate function of blood, heart, liver, kidney and thyroid. exclusion criteria: 1. history of immunodeficiency, including hiv positive, or other acquired or congenital immunodeficiency disease, or history of organ transplantation or allogeneic bone marrow transplantation; 2. unresectable tumor evaluated by investigator; 3. present of poorly controlled cardiac symptoms or disease, including but not limited to: (1) heart failure with nyha class ii or above (2) unstable angina, （3）myocardial infarction occurred within 1 year (4) clinical significance supraventricular or ventricular arrhythmias without clinical intervention or poorly controlled after clinical intervention; 4. with tumors in other sites; 5. history of any active autoimmune disease, including but not limited to: interstitial pneumonia, enteritis, hepatitis, hypohysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism (may be considered after hormone replacement therapy);patients with psoriasis or childhood asthma/allergy who have been in complete remission and do not need any intervention as adults may be considered for inclusion, but patients requiring medical intervention with bronchodilators may not be included; 6. has a history of allergy to monoclonal antibody, any component of pd-1 inhibitor, s-1 and oxaliplatin; 7. with any mental illness; 8. pregnant or lactating women.

Keywords: gastric cancer neoadjuvant chemoimmunotherapy neoadjuvant immunotherapy
endometrial biopsy in infertile patients

Conditions: Infertility

Summary: when a woman becomes pregnant, the fertilized egg attaches itself to the lining of the uterus (endometrium). the endometrium is constantly changing throughout a woman's menstrual cycle in response to the female hormones estrogen and progesterone. the endometrium must have certain characteristics (be at a specific phase in its cycle) in order for the fertilized egg to successfully attach. infertility may be caused by an "out of phase" endometrium (i.e., the endometrium doesn't have the right characteristics when the fertilized egg reaches it). the purpose of this study is to evaluate whether the endometrial biopsy is useful in predicting the potential for becoming pregnant and bearing a child.

this study will evaluate the utility of the endometrial biopsy as a tool for the routine evaluation of the luteal phase of women presenting for infertility evaluation. the study will establish whether the mid-luteal or late-luteal phase is the most appropriate time to perform an endometrial biopsy. the study will be conducted through the multi-center reproductive medicine network. women with a history of infertility will be age matched to fertile women (controls). women will be randomized either to the mid-luteal phase (7 to 8 days post-ovulation) endometrial biopsy group or to the late-luteal phase (12 to 13 days post-ovulation) endometrial biopsy group. endometrial specimens will be evaluated histologically by a "blinded" pathologist.

Eligibility criteria:
inclusion criteria for fertile patients (controls) * no history of involuntary primary or secondary infertility * willingness to discontinue hormonal contraceptives for 1 month prior to and through the duration of the study * at least 1 child delivered within 24 months prior to study entry * most recent pregnancy resulting in a live birth (no interim spontaneous abortions) * tubal ligation within 24 months of study entry is acceptable if all other criteria are met inclusion criteria for infertile patients * history of primary or secondary infertility for a period of at least 12 months * no hormonal treatments in the month preceding study entry * no history of tubal ligation

Keywords: endometrium luteal phase endometrial biopsy
a long-term safety follow-up study of scm-agh in patients who completed scm-apt2001 study

Conditions: Pancreatitis, Acute

Summary: this is a long-term safety follow-up study of the phase i/iia multicenter study of scm-agh in subjects with moderate to severe acute pancreatitis. subjects will be followed up for a maximum period of 240 weeks after the first dose of investigational product. only subjects previously enrolled in protocol scm-apt2001 (clinicaltrials.gov id: nct04189419) will be eligible for this long-term follow-up protocol.

subjects who meet all eligibility criteria for long term follow-up(ltfu) study participation at the scm-apt2001 end of treatment(eot) visit may continue ltfu for a maximum period of up to 240 weeks post first dose of investigational product. no additional dosing will be administered on this ltfu protocol.

Eligibility criteria:
inclusion criteria: * subjects who provide written informed consent * subjects who have received at least 1 dose of scm-agh in the scm-apt2001 study exclusion criteria: * n/a

Keywords: stem cell therapy scm-agh pancreatitis
visual quality change of eyes implanted with diffractive multifocal intraocular lens after cataract surgery

Conditions: Dry Eye; Vision Disorders; Quality of Life

Summary: in this study, the investigators examined the subjective visual quality including logmar uncorrected distance visual acuity (ucdva), best corrected distance visual acuity (bcdva),uncorrected intermediate visual acuity (uciva), distance corrected intermediate visual acuity (dciva), uncorrected near visual acuity (ucnva) ,distance corrected near visual acuity (dcnva),using logmar visual acuity chart,and the objective visual quality including modulation transfer function (mtf), strehl ratio(sr), objective scatter index (osi), oqas value (ov),and the tear-film quality dynamics including the tear break-up time and the tear-film osi between the eyes with multifocal lens and monofocal lenses by optical quality analysis system (oqas).

50 eyes of 50 cataract patients scheduled for phacoemulsification surgery were recruited, the multifocal group (25 eyes) ，were implantation with tecnis® zmb00；and the monofocal group (25 eyes) were implantation with tecnis® zcb00. methods: all eyes were examined by logmar visual acuity chart and optical quality analysis system (oqas) at 1 week, 1 month, 3 month, 6 month,12 month after surgery for the subjective and objective visual quality change during the first year. measures:subjective and objective visual quality were evaluated.tear-film quality dynamicswere evaluated.

Eligibility criteria:
inclusion criteria: * eyes with an axial length of 22.00 to 25.00 mm with age-related cataract. exclusion criteria: * preoperative exclusion criteria included diabetes, history of ocular surgery or inflammation. * patients who could not be available for follow-up.

Keywords: visual acuity objective visual quality multifocal intraocular lens tear-film quality dynamics