Kornimate/medical-research-clean huggingface dataset:
tart cherry juice for sleep in older adults with insomnia: a pilot study of feasibility and comprehensive mechanisms

Conditions: Sleep Problems; Insomnia

Summary: the purpose of this research study is test if a study that asks older adults with sleep problems to consume tart cherry products is feasible and determine if it can change sleep patterns. this study is a total of 12 weeks. participants will be asked to consume tart cherry juice for 4 weeks and the placebo juice for 4 weeks, while wearing a digital monitor that measures sleep. blood (about 3 teaspoons) and urine (about 2 tablespoons) samples will be taken before and after consuming both juices to measure certain biological markers related to sleep.

the overall goal of this study is to determine feasibility of a tart cherry juice intervention in older adults, and generate preliminary data of outcomes and mechanisms related to sleep. we propose a 2-arm randomized, double-blind, cross-over study in 20 older adults with self-reported insomnia. participants will consume 240 ml of tart cherry juice or placebo (calorically matched to the tart cherry juice beverage, but theoretically devoid of melatonin, tryptophan, magnesium and flavonoids), twice/evening for 4 weeks in a randomly assigned order.

Eligibility criteria:
inclusion criteria: * men and women aged ≥65 years * self-reporting insomnia (e.g., trouble sleeping approximately 3 nights a week for at least 6 months and/or an insomnia severity index score ≥ 10 points) * usual bed-time between 8:00 pm and 1:00 am exclusion criteria: * unwilling to follow the study protocol * inability to properly use the wearable device, complete smartphone-based surveys, or follow the intervention protocol * self-report of medically diagnosed sleep disorders except insomnia (e.g., sleep apnea) * current and consistent use of sleep aids or hypnotic prescriptions (e.g., trazadone) * self-report of cognitive impairment, dementia, or other neurological disorder * are on unstable medications (i.e., change within the last 3 months) for other conditions * have an allergy to the intervention products * self-report history of diabetes * current alcohol (alcohol use disorders identification test ≥4 points33,34) or drug use disorder (drug abuse screening test,35,36 dast-10\>2 points) * are excessive caffeine drinkers (\>5 cups of caffeinated beverages a day) * any other reason/condition the pi and investigative team believe this intervention would be unsafe

Keywords: montmorency cherry flavonoids sleep quality
antibiotic prophylaxis in prelabor rupture of membranes at term

Conditions: Chorioamnionitis; Puerperal Endometritis; Neonatal Early Onset Sepsis; Neonatal Meningitis; Neonatal Pneumonia

Summary: the aims of this study are to determine whether antibiotics administered routinely in women presenting with premature rupture of membranes later than the 37+0 weeks of gestation can alter the rate of maternal and neonatal infection and to compare these rates between prompt (\< 12 hour) and delayed (≥ 12 hour) induction in the group of patients not submitted to antibiotic prophylaxis.


Eligibility criteria:
inclusion criteria: * term (≥ 37+0 weeks) singleton pregnancy * a vertex presentation * ruptured membranes for less than 12 hours * negative group b streptococcus (gbs) culture performed between 35 and 37 weeks exclusion criteria: * active labor * absence of gbs culture or indication for gbs antibiotic prophylaxis (such as maternal gbs colonization between 35 and 37 weeks, gbs bacteriuria, prior infant with gbs sepsis) * contraindication to expectant management (such as fetal distress, meconium staining of the amniotic fluid or chorioamnionitis) or to vaginal delivery

Keywords: premature rupture of membranes term pregnancy chorioamnionitis endometritis neonatal sepsis antibiotic prophylaxis
does cefoxitin or piperacillin-tazobactam prevent postoperative surgical site infections after pancreatoduodenectomy?

Conditions: Pancreatic Cancer; Pancreas Cancer; Pancreatic Diseases

Summary: the purpose of this study is to figure out which commonly used antibiotic, cefoxitin or piperacillin-tazobactam, is better at decreasing the rate of surgical site infections after pancreatoduodenectomy.


Eligibility criteria:
inclusion criteria: * age \>/= 18 years * patients undergoing elective pancreatoduodenectomy (pd) for any diagnosis/indication exclusion criteria: * patients undergoing a minimally invasive pd, such as laparoscopic or robotic pd * patients with known and documented allergies to any of the penicillins, cephalosporins, or β-lactamase inhibitors * patients who are otherwise ineligible to receive the antibiotics in this study * patients highly unlikely to undergo pd according to the surgeon's judgment, such as conditions amenable to pancreas enucleation, ampullectomy, etc. * patients with long-term glucocorticosteroid use. the following uses of corticosteroids are permitted: single doses, topical applications (e.g., for rash), inhaled sprays (e.g., for obstructive airways diseases), eye drops or local injections (e.g., intra-articular) * patients unable to provide informed consent * creatinine clearance (crcl) \</= 40 ml/min * patients receiving hemodialysis or peritoneal dialysis * pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hcg laboratory test * patients with a known bacterial infection present at the time of surgery or who received antimicrobial therapy within 7 days prior to surgery

Keywords: pancreatoduodenectomy 17-418 cefoxitin piperacillin-tazobactam
midodrine is effective in management of intradialytic hypotension among critically-ill patients with acute kidney injury

Conditions: Acute Kidney Injury

Summary: the aim of this randomized trial was to assess the efficacy of oral midodrine tablets for the management of intradialytic hypotension among critically ill patients with acute kidney injury.

in this open -label study, patients in icu with acute kidney injury are randomized to either midodrine tablets or placebo. the number of intradialytic episodes and both systolic and diastolic blood pressure between both groups are compared. mortality and adverse effects are monitored and compared as well.

Eligibility criteria:
inclusion criteria: * icu patients * acute kidney injury * age above 18 years * documented hypotension during dialysis exclusion criteria: * packed red blood cells transfusion * intravenous inotropes * alteration of blood pressure medications

Keywords: acute kidney injury midodrine intensive care unit
effects of exercise on markers of inflammation in skeletal muscle in elderly hip fracture patients

Conditions: Hip Fractures; Muscular Atrophy

Summary: decreased skeletal muscle mass is a prevalent condition among the elderly, and an important cause of disability and functional decline. the declines in muscle mass associated with aging may be related to alterations in specific kinds of growth factors in the muscle. elderly hip fracture patients often have significant decreases in muscle mass. the purpose of this study is to investigate whether an exercise program can induce changes in muscle growth factors that are associated with increases in muscle mass and strength in elderly hip fracture patients.


Eligibility criteria:
inclusion criteria: * enrollment in hsc protocol #97-0695 "rehabilitation intensification post hip fracture" * community-dwelling * hip fracture within 16 weeks of the screening assessment for protocol 97-0695 * persistent mobility and/or adl impairments, but independent in ambulation * modified physical performance test (ppt) score between 12 and 28

Keywords: sarcopenia
the clinical and pharmacoeconomic impact of rapid diagnostic test (multiplex pcr filmarray) on antimicrobial decision making compared to conventional decision making among critically ill patients

Conditions: Sepsis

Summary: we will show in this study the impact of use the rapid diagnostic method (multiplex pcr filmarray) on clinical and pharmacoeconomic aspects among critically ill patients.

prospective and retrospective study on 100 patients complaining from sepsis in intensive care unit in international medical center. two phase study 50 patients before and 50 patients after use rapid diagnostic test (multiplex pcr filmarray)

Eligibility criteria:
inclusion criteria: * age between 18 and 85 years * critically ill patients admitted to icu, diagnosed as sepsis. exclusion criteria: * surviving time less than 48 hours.
prolonged hypercoagulability following major liver resection for malignancy

Conditions: Hepatic Disease; Surgery-Complications; Hypercoagulability; Thrombosis

Summary: this clinical trial will investigate the ability of thromboelastrogrpahy (teg®) to detect hypercoagulability after liver surgery and will examine the effect of extended thromboprophylaxis (medical treatment to prevent the development of blood clots inside blood vessels) in patients undergoing liver surgery for cancer treatment. the liver plays a key role in regulating the process of blood clotting. as a result, blood clots are a major cause of complications and death following liver surgery. this is especially true in cancer patients who are at a higher risk of developing blood clots. current methods for preventing clotting complications after liver surgery include conventional coagulation blood tests (ccts) and anticoagulant drugs, such as low molecular weight heparins (lmwhs). current lmwh treatment is prescribed for one month after surgery, but studies show that the risk of developing blood clots can last up to 3 months. studies also show that ccts may not be as effective in detecting clotting issues as more comprehensive testing systems, such as teg. this study will randomize 50 participants to receive 90 days of thromboprophylaxis (using the lmwh redesca) or the standard of care 30 days (using the lmwh fragmin) after liver surgery. the medication will be given by injection, similar to a regular vaccine or an insulin injection. participants will inject the medication every day, for 30 or 90 days, after surgery. participants will also have their blood tested for clotting issues via teg testing before surgery and on post-operative days 1,3,5,30 and 90. after surgery, participants will be monitored by their surgeon for clotting complications and 3 year disease-free survival.


Eligibility criteria:
inclusion criteria: 1. adults aged 18 years or older at the time of enrollment. 2. requiring major liver resection (\>2 liver sections) for any oncologic indication. 3. requiring postoperative thromboprophylaxis will be included. 4. willing and able to perform subcutaneous injections according to the study protocol, or receive injections form a caregiver delegated by the participant. exclusion criteria: 1. anyone below 18 years of age. 2. patients on current anticoagulant and/or antiplatelet therapy 3. patients with a history of thrombotic events 4. patients with a coagulation disorder. 5. patients with recognized thrombophilia. 6. patients who cannot understand/speak or read in english.
biomarkers in post-menopausal women receiving flaxseed

Conditions: No Evidence of Disease

Summary: this randomized clinical trial studies biomarkers in post-menopausal women receiving flaxseed. studying samples of blood, urine, and feces in the laboratory from participants receiving flaxseed may help doctors understand the effects of flaxseed on biomarkers.

primary objectives: i. to determine associations between the composition of the gut bacterial communities and baseline levels of the mammalian lignans and steroid hormones. ii. to determine how variation in gut microbial community composition and in steroid hormone and xenobiotic metabolizing genes affects the metabolism of mammalian lignans and steroid hormones after exposure to a lignan-rich food (flaxseed). iii. to determine how these associations differ by race (i.e., african american and european american women). outline: participants are randomized to 1 of 2 treatment groups. group i: participants receive flaxseed orally (po) daily for 6 weeks. after a usual diet "washout" period of 8 weeks, patients crossover to group ii. group ii: participants maintain a usual diet for 6 weeks. after a usual diet "washout" period of 8 weeks, patients crossover to group i. after completion of study treatment, participants are followed up for 30 days.

Eligibility criteria:
inclusion criteria: * participant must understand the investigational nature of this study and sign an independent ethics committee/institutional review board approved written informed consent form prior to receiving any study related procedure * participant must be a non-hispanic white or non-hispanic black (self-reported race) woman 45 to 80 years of age and postmenopausal; postmenopausal will be defined as no menstrual cycle in the past 12 months; women with a hysterectomy but with intact ovaries will be included if aged \>= 55 years * willingness to comply with the requirements of the study exclusion criteria: * unwilling or unable to follow protocol requirements * self-reported race other than non-hispanic white or non-hispanic black * use, in the 2 months prior to week 1 visit, of antibiotics, hormone replacement therapy, nonprescription hormones or herbal supplements for menopausal symptoms, or flaxseed supplements * nut or seed allergy * self-reported inflammatory bowel disease * gastric bypass * use of thyroid replacement medication (synthroid or similar) for \< 1 year * any condition which in the investigator's opinion deems the participant an unsuitable candidate to receive flaxseed * chemotherapy/radiation within the past year * body weight greater than 400 pounds (limit of tanita scale)

Keywords: gut microbiome hormones women race phytoestrogens
postoperative cyclic oral contraceptive use for the prevention of endometrioma recurrence

Conditions: Endometriosis

Summary: ovarian endometriotic cyst (endometrioma) is one of the most common endometriotic lesions, and conservative laparoscopic surgery is the treatment of choice. however, the recurrence after surgery is common. as repetitive surgery leads to morbidities and ovarian function decrease, recurrence after surgery frustrates both patients and clinicians. in this aspect, medical treatments have been offered after surgery to prevent or delay the recurrence. gonadotropin-releasing hormone agonist (gnrha) is frequently used in women with advanced endometriosis, but the efficacy is rather controversial. on the other hand, it has been demonstrated that oral contraceptives (ocs) could reduce or delay endometrioma recurrence, but data are still limited. consequently, no one type of postoperative medical therapy has been shown to be superior in reducing the recurrence of endometrioma. the rationale of postoperative medical therapy is that it could eradicate microscopic lesions which were not found and not treated sufficiently during surgery. therefore, the maintenance of strongly suppressed condition induced by postoperative gnrha treatment by addition of ocs could be a promising treatment to prevent the recurrence, but it has not been widely investigated. we performed this retrospective cohort study to evaluate the efficacy of cyclic monophasic low-dose ocs as a maintenance therapy after gnrha treatment for the suppression of endometrioma recurrence.


Eligibility criteria:
inclusion criteria: 1. reproductive aged women who underwent conservative laparoscopic ovarian surgery for endometrioma (asrm stage iii/iv) which was confirmed by pathologic inspection 2. women who were given postoperative gnrha injections every 28 days for 3 or 6 months 3. women with no residual lesion confirmed by ultrasonography after surgery 4. women who were followed up for over 12 months after surgery. exclusion criteria:if they had 1. undergone hysterectomy during an operation 2. been given gnrha injections more than 6 times 3. been given other types of postoperative treatment (progestin or intrauterine device) 4. a history of previous pelvic surgery for endometriosis 5. a history of hormonal treatment before surgery 6. been diagnosed as menopause after surgery 7. contraindications to ocs 8. been identified ovarian endometriomas within 6 months of postoperative evaluation

Keywords: endometrioma recurrence oral contraceptives gonadotropin-releasing hormone agonist
applying breast mask containing cabbage leaves extract to relieve breast discomfort in breastfeeding women

Conditions: Breast Engorgement

Summary: in this article, women were randomly assigned to the breast mask containing cabbage leaves extract group and breast mask without cabbage leaves extract group, and the breast engorgement, pain, hardness, before and after each treatment were measured. at the end of the study breast mask user experience and continued breastfeeding were measured.

breast engorgement as the swelling and distention of breast, which is one of the most common problems often occurs 2-4 days after delivery, resulting in pain and fever, which reduces the intention of mothers to continue breastfeeding and causes to stop breastfeeding in the early postpartum period. there are many conservative treatments for relieving breast engorgement. at present, there have been published studies on the application of medications, cold compresses, warm compresses, massages, gua sha and cabbage leaves compression to breast problems during lactation. previous studies have shown that cabbage leaves compression can relieve the breast engorgement, pain, and hardness of postpartum women. however, safety concerns related to freshness, preservation, and residual pesticides must be considered when using cabbage leaves in a clinical setting. the purpose of this study was to examine whether breast mask containing cabbage leaves extract can improve breast engorgement, pain, and hardness.

Eligibility criteria:
inclusion criteria: * over 18 years old. * breastfeeding. * physiological breast swelling, breast heaviness, lumps, milk plugging, breast pain after childbirth. * able to read and understand chinese. exclusion criteria: * stillbirth * allergy to cabbage or sulfa. * lactation inhibitors agents used. * fever symptoms (\> 38 degrees celsius), including: wound infection, upper respiratory tract infection, urinary tract infection. * breast symptoms, including: nipple cracks, skin damage, breast abscesses, mastitis, malignant tumors. * postpartum complications, including: postpartum hemorrhage, amniotic fluid embolism or other diseases requiring close care.

Keywords: breast engorgement pain hardness
case managers for cvd risk reduction in hiv clinic

Conditions: Cardiovascular Disease; HIV

Summary: the purpose of the study is to assess the efficacy of a case manager/social worker administered, telephone-based educational curriculum in improving cardiovascular disease related outcomes among hiv-infected clinic patients.

fifty high cardiovascular disease risk (cvd) risk clinic patients will be randomized 1:1 to receive either a series of educational pamphlets on cvd risk reduction plus a telephone-based cvd risk reduction curriculum delivered over 24 weeks \[intervention arm\], or the educational pamphlets alone \[control arm\]. anthropomorphic data, blood pressure and lipid profiles will be obtained from patients to assess the efficacy of the intervention in reducing blood pressure and serum low-density lipoprotein levels (ldl).

Eligibility criteria:
inclusion criteria: * in care at the duke infectious diseases clinic for hiv and for at least 24 months * on antiretroviral therapy * 2013 american heart association 10-year ascvd risk score ≥ 15%, with a diagnosis of either hypertension or hyperlipidemia * english literate (able to speak and read at a 6th grade level) * subjects must have the capacity to give legally effective consent. exclusion criteria: * patients with prior diagnosis of acute coronary syndrome, stroke, peripheral vascular disease, and end stage renal disease
posterior pole asymmetry analysis (ppaa) for early glaucoma

Conditions: Glaucoma

Summary: spectrailis optical coherence tomography has come with a new posterior pole asymmetry analysis for glaucoma diagnosis. the aim of the investigators study was to assess its applicability in diagnosing early glaucoma patients.


Eligibility criteria:
inclusion criteria: * age more than 18 years * best corrected visual acuity 20/40 or better * refractive error within ±5d sphere and ±3d cylinder * willingness to participate in the study exclusion criteria: * media opacities preventing imaging * intraocular surgery within the last 6 months * any retinal or neurological disease other than glaucoma that could confound the results of visual field examination and oct.
investigation of efficacy, safety and tolerability of once and twice daily doses of azd1981 in asthmatic patients

Conditions: Asthma Patients

Summary: the study will assess the efficacy, safety and tolerability of azd1981 compared to non-active compound in asthmatic patients.


Eligibility criteria:
inclusion criteria: * men and women. women must be surgically sterilized/postmenopausal or use double barrier method contraception * 6 months history of asthma according to ats definition * prescribed daily dose of ics and laba for at least 3 months prior to visit 2 * pre-bronchodilator fev1 of 40 to 85 % of predicted normal * a total acq5 score of 1.5 or more exclusion criteria: * respiratory infection significantly affecting the asthma * any significant disease and disorder that may put the patient at risk or influence study results * any clinically relevant abnormal findings * a smoking history of more than 10 pack years * intake of oral, rectal or parenteral glucocorticosteroids

Keywords: efficacy safety tolerability dose finding asthma patients
neuroscience education in shoulder pain: clinical trial

Conditions: Shoulder Pain

Summary: objectives: the purpose of this study was to assess the efficacy of a pain neuroscience education programme applied to patients with shoulder pain.

a randomised controlled trial was performed. fifty-five patients satisfied eligibility criteria, agreed to participate, and were randomized into an experimental group (n = 27) or control group (n =28). a manual therapy and exercises program was administered for both groups. in addition, a pain neuroscience education protocol was administered for the experimental group for a whole period of 4 weeks (1 session/week, 75mins per session).

Eligibility criteria:
inclusion criteria: * being 18-70 years of age. * history of shoulder pain of more than 3 months duration. * presence of a painful arc * medical diagnosis of shoulder pain with at least 2 positive impingement tests including neer, hawkins, or jobe test exclusion criteria: * diagnosis of fibromyalgia. * pregnancy. * a history of traumatic onset of shoulder pain. * other histories of shoulder injury. * torn tendons. * ligamentous laxity based on a positive sulcus and apprehension tests. * numbness or tingling in the upper extremity. * previous shoulder or cervical spine surgery. * systemic illness. * corticosteroid injection on the shoulder within 1 year of the study. * physical therapy 6 months before the study.

Keywords: exercise manual therapy shoulder pain pain neuroscience education