Kornimate/medical-research-clean huggingface dataset:
single anastomosis sleeve iejenal bypass in obese patient with hiatus hernia

Conditions: Obesity, Morbid

Summary: single anastomosis sleeve jejunal bypass with hiatal repair for morbid obesity with reflux manifestations

preoperative endoscopy was done and if hiatus hernia was present the patient is undergo single anastomosis sleeve jejunal bypass with hiatal repair for morbid obesity with reflux manifestations

Eligibility criteria:
inclusion criteria: * obese patients with bmi more than 40 with or without co-morbidity or more than 35 with co-morbidity * patients fit for laparoscopic surgery * give approval to share in the study exclusion criteria: * patients refused to share in the study * patients unfit for surgery * patients aged less than 18 and older than 60 * patient with previous upper abdominal surgery either for obesity or other diseases * revisional bariatric procedures
study on wood-plastic composite for circumferential casting

Conditions: Bone Fracture; Radius Fracture; Ankle Fracture

Summary: the purpose of study is to verify that woodcast circular system performs safely and effectively in its intended use.

an ecologically friendly and biodegradable wood-plastic composite-cast is studied. the purpose of the study is to verify that woodcast circular system performs safely and effectively in its intended use. patients, who need immobilization of extremity (including for example scaphoid fracture of the wrist or ankle fracture) will be participating in the study. various casting techniques with novel woodcast material will be studied.

Eligibility criteria:
inclusion criteria: * patient treatment involves circular casting; * age 0-90 years; * mother tongue finnish or swedish exclusion criteria: * open fracture; * other fractures or a previous fracture; * a previous or simultaneous tendon-, nerve-, or vascular injury to the extremity yo be treated; * a multiple injured extremity; * decreased co-operation of the patient; * malignancy; * an illness affecting the general health.

Keywords: cast splint circumferential casting casting techniques fracture in extremity
the circadian rhythm of icu patients with acute myocardial infraction and the effect of light therapy

Conditions: Circadian Dysrhythmia; Delirium

Summary: by using subjective and objective measurements, the investigators monitor the change of circadian rhythm in intensive care unit (icu) patients with acute myocardial infarction and the effect of light therapy.

the investigators include 70 patients who are admitted to coronary care unit due to coronary artery disease, with severity between killip i-iii and age between 35-85. participants are randomly assigned to 2 groups, the experimental group (blue light) and the placebo group (white light). both groups receive light therapy or white light daily between 8am to 12pm. the investigators use actigraphy and heart rate variation analysis, and check melatonin level as objective measurements. the investigators use delirium scales to evaluate delirium and its severity. the light therapy is stopped once a participant is diagnosed of delirium or transferred, and the investigators keep following participants until discharge to evaluate the prognosis.

Eligibility criteria:
inclusion criteria: * diagnosis for admission is acute myocardial infarction with severity between killip i-iii. * age is between 35-85. * participants who are willing to participate in the study and sign the informed consent. exclusion criteria: * using sedative hypnotic drugs. * blindness or severe cataract. * neurological diseases such as epilepsy, brain injury, or stroke. * severe mental disorder such as major depressive disorder, bipolar disorder, schizophrenia, intellectual disability or substance use disorders. * unable to communicate. * participants who are unwilling to participate in the study or refuse to sign the informed consent. * participants who are not suitable to include in this study, evaluate by pi or co-pi.

Keywords: circadian rhythm icu acute myocardial infarction delirium light therapy
comparison of single and multiple-dose methotrexate therapy for ectopic pregnancy

Conditions: Pregnancy, Ectopic

Summary: the aim of this study was to compare single dose methotrexate (mtx) to multiple dose mtx.


Eligibility criteria:
inclusion criteria: * unruptured tubal ep * gestational mass of less than or equal to 3.5 cm in ultrasonography report exclusion criteria: * hemodynamic instability * contraindications related to the use of mtx * hepatic * renal and active pulmonary diseases * peptic ulcer * immune deficiency status * alcohol abuse * blood dyscreasia
a retrospective chart review to investigate clinical remission in patients with severe asthma treated with biologics in the united kingdom national health service

Conditions: Asthma

Summary: asthma is a common lung condition that causes occasional breathing difficulties and affects around 5.4 million people in the uk of all ages. common symptoms can include wheezing when breathing, breathlessness, a tight chest and coughing. however, these symptoms can get worse and lead to an asthma attack which can be fatal. there is currently no cure for asthma but there are treatments that can help keep the symptoms under control. the main types of treatment include reliever inhalers used when needed quickly to reverse asthma symptoms for a short time, and preventer inhalers that are used everyday to prevent symptoms for starting. unfortunately, not all patients are able to control their asthma on these treatments alone. biologic treatments, also known as monoclonal antibodies, have been introduced to treat certain types of severe asthma over recent years. these specialist treatments use antibodies produced from cells in a laboratory to help reduce inflammation and might offer the possibility of higher levels of disease control including the reduction or absence of symptoms and normal lung function. this higher level of disease control is called remission. this study aims to understand whether or not remission is possible in patients with severe asthmas treated with biologics in the nhs. this study will take place a 4 specialist asthma centres in the uk and seeks to include retrospective data from approximately 450 adult patients that were treated with biologics as part of routine care between 01 october 2021 and 30 september 2022. data will be collected directly from medical records and entered into the study database in a pseudonymised format by members of the direct care team ready for analysis.


Eligibility criteria:
inclusion criteria: * initiated on a biologic treatment for sa between 1st october 2021 and 30th september 2022 * patients who received ≥1 dose of biologic treatment * patients aged ≥18 years at index exclusion criteria: * patients who were involved in any interventional clinical trial during the study period (+/- 12 months from index).
quality of life in patients undergoing embolization using yttrium y 90 glass microspheres for primary or metastatic liver cancer

Conditions: Liver Cancer; Metastatic Cancer

Summary: rationale: learning about quality of life in patients with cancer undergoing embolization may help doctors learn about the side effects of treatment and plan the best treatment. purpose: this clinical trial is studying quality of life in patients undergoing embolization using yttrium y 90 glass microspheres for primary or metastatic liver cancer.

objectives: primary * assess the quality of life (qol) as defined by the presence or absence of physical, social, emotional, and functional distress in patients with primary or metastatic liver cancer undergoing treatment with radioembolization or transcatheter arterial embolization. * compare the time course of qol measures between treatment groups in patients treated with these regimens. * compare the time course of qol measures between patient subgroups defined by pre-treatment quality of life or tumor burden. outline: patients complete fact-hep version 4 surveys on quality of life prior to initiation of embolization, and at 2 weeks and 1 month after completion of embolization.

Eligibility criteria:
disease characteristics: * diagnosis of primary hepatocellular cancer or metastatic liver cancer * planning radioembolization or transcatheter arterial embolization using yttrium y 90 glass microspheres * no encephalopathy patient characteristics: * ecog performance status 0-2 * bilirubin ≤ 3 mg/dl * able to comply with study procedures prior concurrent therapy: * no prior treatment with radioembolization or transcatheter arterial embolization

Keywords: adult primary hepatocellular carcinoma advanced adult primary liver cancer liver metastases recurrent adult primary liver cancer
a double-blind study to investigate efficacy, safety and tolerability of bay 1142524 in patients after acute myocardial infarction with left-ventricular dysfunction

Conditions: Myocardial Infarction

Summary: the purpose of the trial is the analysis of safety and efficacy of the chymase inhibitor bay1142524 at a dose of 25 mg bid in comparison to placebo using a 6 months treatment period in patients with left-ventricular (lv) dysfunction after myocardial infarction (mi). bay1142524 or placebo will be given on top of evidence-based standard of care for left-ventricular dysfunction after myocardial infarction. primary objective is the analysis of first signs of efficacy as determined by favourable changes in functional parameters of adverse cardiac remodelling (i.e. endsystolic and enddiastolic volume index, ejection fraction). secondary objective is the analysis of safety and tolerability as evidenced by the incidence and severity of adverse events. 30 patients have to complete treatment with verum and 30 patients have to complete treatment with placebo.


Eligibility criteria:
inclusion criteria: * patients with first st elevation myocardial infarction (stemi) treated with primary percutaneous intervention (pci) or thrombolysis within 24 hours after symptom onset * diagnosis of stemi requires the presence of the following three criteria: * typical clinical symptoms such as chest pain, shortness of breath for more than 20 minutes related to the myocardial infarction * new st elevation indicating myocardial infarction * significant elevation in troponin t or i with at least one value above the 99th percentile upper reference limit (url) and/or elevation creatine kinase (ck) and creatine kinase mb (6-10% of total ck) * at the screening period, on day 5 to 9 after mi, patients have to have a lvef ≤ 45% and an infarct size \>10% lv mass (as measured by lge-mri, central-blinded evaluation) exclusion criteria: * contraindication to perform contrast-enhanced cardiac mri * lvef \< 20% * history of heart failure or lvef \< 50% before occurrence of the first stemi * infarct size \> 45% (g/g; lv mass) between 5 and 9 days after myocardial infarction * nyha (new york heart association) class iv at randomization * any planned cardiac intervention after baseline mri or any other planned operations * non-ischemic causes for cardiomyopathy * diagnosis of atrial fibrillation * systolic blood pressure \ 180 mm hg; diastolic blood pressure \ 110 mm hg, heart rate \ 100 beat/minute; mean of triplicate values at randomization * clinically relevant hepatic dysfunction
a randomized, double-blinded study of simvastatin 20 mg/day versus vytorin 10/20 in subjects with lipid profiles not meeting current ncep guidelines, following a low-carbohydrate diet

Conditions: Hyperlipidemia

Summary: people who follow a low-carbohydrate diet typically experience a decrease in triglycerides and increase in hdl-c level, but fail to lower their ldl cholesterol (ldl-c). such patients may require lipid-lowering therapy. statins may not be the most effective strategy for patients on this diet, since they typically consume a greater amount of saturated fat and cholesterol. absorbed cholesterol may contribute more to their circulating plasma ldl-c. we hypothesize that patients following a low carbohydrate diet would experience a significantly greater decrease in ldl-c by taking ezetimibe 10 mg, a drug that blocks cholesterol uptake in the intestine, in addition to simvastatin 20 mg, when compared to taking simvastatin 20 mg alone.


Eligibility criteria:
inclusion criteria: * moderately obese with hyperlipidemia exclusion criteria: * recent unstable heart or lung condition * current use of other lipid modifying drugs * hepatic disease * pregnancy or lactation
effect of aerobic exercises versus incentive spirometer device on post-covid pulmonary fibrosis patients

Conditions: Lung Fibrosis Interstitial; Post-COVID-19 Syndrome

Summary: the aim of this study will be to investigate the effect of aerobic exercises vs incentive spirometer device on post-covid patients with residual lung diseases.

to our knowledge, there have been no enough studies that investigated the effect of aerobic exercise and incentive spirometer in pulmonary rehabilitation on post-covid syndrome patients. therefore, this study may open up ways to other researchers to investigate and build up on this effect if present and address such an important issue. the finding of this proposed work may help patients with post-covid syndrome and complain of lung diseases by addressing their complains of symptoms like chest pain, dyspnea, and cough and provide a possible solution to enhance their quality of life and increase their participation in daily life activities. patients of post-covid syndrome with residual lung problems will be recruited after approval of ethical committee of the faculty of physical therapy, cairo university. all participants will sign a written informed consent form. the subjects will be randomly assigned into one of three groups: * group i (experimental) will receive aerobic exercises program and traditional chest physiotherapy. * group ii (experimental) will receive incentive spirometer device treatment and traditional chest physiotherapy. * group iii (control) will receive traditional chest physiotherapy only. the measures will be taken before and after treatment program.

Eligibility criteria:
inclusion criteria: * hemodynamic stable (map not less than 60mmhg, systolic pressure \>80mmhg and diastolic pressure not \<60mmhg) * age from 40 to 85 years. * both sexes. * all patients were positive covid-19 infected patients and passed at least 4 weeks after confirmation. * all patients suffer from respiratory complications. * all patients included are actively breathing. * all patients included are fully aware and conscious. exclusion criteria: * hemodynamic instability. * severe head injury. * increased intracranial pressure. * anemic hb\<8. * active smoking. * severe bronchospasm. * low bp (systole \<80, diastole \<60). * subcutaneous emphysema. * rip fractures. * untreated pneumothorax.
health promotion on young adults with high risk disability for mental health

Conditions: Mental Health Wellness 1

Summary: 1. the positive outcomes reported by participants in experimental group after two weeks of interventions will be significantly better than before interventions. 2. the positive outcomes reported by participants in experimental group will be significantly better than those in control group after two weeks of providing prevention model interventions. 3. the positive outcomes reported by participants in experimental group will be significantly better than those in control group after six months of providing prevention model interventions.

early finding for people with high mental risk plays the important role in mental health promotion. in literature, before specific psychotic symptoms appear, individuals may experience a period of nonspecific symptoms and growing functional impairment. early interventions may alter the natural course of mental diseases and improve treatment outcomes. so that, the purpose of this study is to develop a screen and prevention mode for identifying young adults with high risk status of mental health disability. the psychosocial intervention strategies for emotional and cognitive support in prevention model based on health promotion theory will be used for this study. participants in this experimental design study will be randomly assigned into experimental and control groups. four scales and objective physical assessments are used for evaluating study outcomes. the pre- and post-test will be held before and one week after prevention interventions. in addition, follow-ups will be included for understanding long-term outcomes of the effectiveness of the screen prevention model.

Eligibility criteria:
inclusion criteria: * age 20-65 years, (chinese version of schizotypal personality questionnaire-brief \> 17 scores, or chinese mandarin state trait anxiety inventory y2 \> 60 scores), and agree to participants. exclusion criteria: * had been diagnosed as schizophrenia, bipolar disorders, and major depression.

Keywords: prodrome mental illness health promotion lifestyle behavior
multisite study: parental training using video modelling to develop social skills in children with autism

Conditions: Autism Spectrum Disorders

Summary: this is a brazilian multisite study to test the efficacy of an applied behavior analysis (aba) parent training using video modeling to teach parents of children with autism techniques to apply to their children in order to improve eye contact and joint attention behaviors. our hypothesis is that children with autism whose parents will be trained by videomodeling will have better eye contact and joint attention behaviors compared to children with autism whose parents will not be trained.

applied behavior analysis (aba) is an intervention with proven efficacy in treating impairments on social functioning and daily-life activities of individuals with autism spectrum disorder (asd). in brazil we have a limited number of qualified professionals and an increasing demand of families non-served in the public health system. our main objective is to standardize and test the efficacy of a model for parent training using video modeling for teaching eye contact and joint attention behaviors in children with asd. these two behaviors are essential to develop adequate social interaction, the core impaired domain in asd. it is a multisite study to be carried out at the universidade federal de são paulo, universidade de são paulo and universidade presbiteriana mackenzie. the sample will be composed of 70 children divided in control and intervention groups that will be randomly chosen. the intervention should be carried out in 21 weeks.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of autism spectrum disorders * diagnosis of autism spectrum disorders by means of adi * iq equal or lower than 70 by means of son * main caregiver's level of education \> primary education exclusion criteria: * iq lower than 50 by means of son * child who is receiving aba therapy at least 10 hours per week * main caregiver diagnosed with autism spectrum disorders

Keywords: autism videomodeling behavioral therapy parental training
the path study: cognitive and inflammation targeted gut-brain interventions in alcohol; probiotics, alcohol, transcutaneous vagus nerve stimulation, and hiv study

Conditions: Cognition; Gut Microbiome

Summary: this project uses a hybrid trial design to evaluate two biomedical interventions targeting the gut-brain axis. one intervention is portable transcutaneous vagus nerve stimulator, tvns, that is hypothesized to stimulate the autonomic nervous system, resulting in decreased inflammation and improved cognition. the second intervention is a probiotic supplement intended to replace gut bacteria that are associated with dysbiosis in persons with hiv and alcohol consumption.


Eligibility criteria:
inclusion criteria: * age 35-70 years * english or spanish speaking * alcohol users * cognitive impairment * current cd4\>350 exclusion criteria: * diagnosed major psychiatric illness * consumption of over 300 drinks in the past 30 days * recent opioid use * lifetime history of medically-assisted alcohol detoxification * inpatient or intensive treatment for addictive behaviors in the past 12 months * mri contraindications * current antibiotic treatment * current probiotic use * physical impairment precluding motor response or lying still.
novel therapy of pad by combined transplantation of bmcs

Conditions: Peripheral Arterial Disease

Summary: we analyze the effects of combined intramuscular and intraarterial transplantation of bmcs in patients with pad. bmcs were transplanted into the ischemic limb. after 2 and 13 months walking distance and perfusion indices were monitored.


Eligibility criteria:
inclusion criteria: * severe limb ischemia exclusion criteria: * infectious disease * cancer

Keywords: stem cell therapy peripheral arterial disease limb ischemia
clinical, immunological, morphological and genetic characteristics of patients with dysferlinopathy in the rf

Conditions: Dysferlinopathy; Miyoshi Myopathy; LGMDR2; DMAT

Summary: to evaluate specific characteristics of phenotype, immune status, molecular and genetic as well as morphological characteristics of adult patients with limb-girdle muscular dystrophy r2 in various regions of the russian federation.

a single-center, cohort clinical study. subjects of both sexes aged 18 to 65 inclusive with genetically confirmed diagnosis of limb-girdle muscular dystrophy type r2, who have signed the written informed consent form for this study. the control and case groups should be age- and gender-matched. study objectives: * to evaluate a clinical status of a subject (mmt score; 6-minute walk test; north star assessment for dysferlinopathy (nsad)); * to assess blood biochemistry; * to characterize muscle involvement based on mri results; * to evaluate the progression of muscle involvement based on repeated mri; * to assess cardiac function with ecg, echocg and mri; * to determine a gait pattern and balance characteristics in patients with limb-girdle muscular dystrophy using electrophysiological techniques (neurosoft gait assessment system steadys; stabilometrics and plantography with "sidas"); * to characterize changes in subpopulation compositions of t- and b-lymphocytes, phagocytic activity of leukocytes (a phagocytic index, a phagocyte number, an index of phagocytosis completeness, lysosomal-cation and nbt tests); * to assess average blood cytokine levels in subjects with limb-girdle muscular dystrophy (type r2) in various regions of the russian federation; * to assess average blood cytokine levels in healthy subjects from various regions of the rf; * to analyze the relationship between blood cytokine levels and the presence of a mutation in the dysferlin gene; * to study the expression (immunohistochemistry and western-blotting) and distribution of dysferlin in impaired muscles of subjects with lgmdr2. the clinical study includes the stages as follows: 1. subject enrollment - 24 months 2. data collection and analysis - 12 months 3. study report - 30 days.

Eligibility criteria:
inclusion criteria: * 18 to 85 (inclusive) years-old subjects of both sexes; * a signed written informed consent form; * genetically confirmed diagnosis of limb-girdle muscular dystrophy (type 2b) (a case group) exclusion criteria: * a subject who is an investigator, study assistant, study coordinator and a member of the other personnel indirectly or directly associated with the conduct of the study; * acute medical conditions associated with visceral dysfunction, life-threatening conditions which occurred less than 6 months prior to enrollment into the study such as acute cardiac, renal, hepatic insufficiency, myocardial infarction or an acute cerebrovascular accident (stroke) as well as infectious diseases; * excessive alcohol consumption (\> 20 g/day).

Keywords: lgmdr2 miyoshi myopathy dysferlinopathy dysf dmat