Kornimate/medical-research-clean huggingface dataset:
the effect of testosteron replacement treatment on the fibroblast growth factor-23, asymmetric dimethylarginine and vitamin d levels in the congenital hypogonadotropic hypogonadism

Conditions: Hypogonadism

Summary: the study is designed to answer the following questions: 1) what is the effect of testosteron replacement treatment on the endothelial dysfunction. 2/ what is the effect of testosteron replacement on the bone mineral metabolism.

this is an interventional study which is examine the effect of testosteron replacement treatment on the endothelial dysfunction and bone mineral metabolism in hypogonadotropic hypogonadal patients.

Eligibility criteria:
inclusion criteria: * men * congenital hypogonadism * treatment naive exclusion criteria: * previous history of androgen replacement * hypertension * diabetes mellitus

Keywords: endothelial dysfunction bone mineral metabolism testosteron replacement treatment
optimizing transcranial direct current stimulation for motor recovery from severe post-stroke hemiparesis

Conditions: Stroke; Hemiparesis

Summary: individuals who experienced a stroke over one year ago will be randomly assigned to receive 1 of 4 different conditions of brain stimulation. all individuals will receive therapy of the hand and arm following the stimulation. this study will try to determine which brain stimulation condition leads to the greatest improvement in hand and arm function.

this study will look at the effects of a painless, non-invasive form of brain stimulation, called transcranial direct current stimulation, or tdcs. tdcs is thought to increase the brain's ability to change. participants will be assigned to one of four groups by chance. three groups will receive tdcs at a level expected to increase the brain's ability to change, and will vary by the areas of the brain that are stimulated. the fourth group will receive tdcs at a level not thought to affect the brain's ability to change. all participants will receive intensive therapy of their impaired arm and hand, focusing on exercises that will improve their ability to function in daily life.

Eligibility criteria:
inclusion criteria: * 12 or more months post-stroke * inability to extend the affected metacarpophalangeal joints at least 10 degrees and the wrist 20 degrees exclusion criteria: * addition or change in dosage of drugs known to exert detrimental effects on motor recovery within 3 month of enrollment * untreated depression * history of multiple strokes exclusion criteria for tms evaluations: * history of head injury with loss of consciousness * history of severe alcohol or drug abuse, or psychiatric illness * positive pregnancy test or being of childbearing age and not using appropriate contraception * presence of ferromagnetic material in the cranium except in the mouth, including metal fragments from occupational exposure and surgical clips in or near the brain * cardiac or neural pacemakers

Keywords: neuroplasticity rehabilitation transcranial direct current stimulation motor training
trial of motivational interviewing in adolescents with diabetes

Conditions: Diabetes Mellitus

Summary: the management of diabetes in adolescence presents significant difficulties due to psychological and physiological factors. blood glucose control deteriorates in this age group and poor management threatens long-term health. motivational interviewing, a psychological intervention designed to facilitate behaviour change, has recently been used with a small group of teenagers, producing improved blood glucose control. to establish the impact of this intervention and its key components, we plan to compare the outcome in several clinics over a longer period of time in a larger number of adolescents selected at random to undergo motivational interviewing or to act as a control group. if successful this approach has potential to be incorporated into the routine clinical care of adolescents with diabetes.

diabetes in adolescence is associated with deterioration in glycaemic control and self-care, resulting in increased risk of long-term complications. although psychosocial factors are recognized as playing an important part in these changes and therefore in clinical management, there are few indicators from research studies of practical, effective interventions. motivational interviewing is a counselling approach designed to facilitate decision-making about behaviour change. it has been shown to be effective in a variety of clinical settings, including diabetes care in an adult population. in a bda-funded pilot study of motivational interviewing with adolescents, our group has shown that the intervention improves glycaemic control (glycosylated haemoglobin), at least in the short-term. this study aims to replicate and extend the findings of the pilot study in a multicentre, randomised, controlled trial over a longer intervention period with a larger sample. the intervention will be monitored to facilitate analysis and description of key components. other psychological variables thought to be of significance in the self-care of adolescents with diabetes will be measured. if the results indicate that this is a successful intervention, the method has potential to be disseminated and applied within routine clinical practice.

Eligibility criteria:
inclusion criteria: * age 14-17 * with type 1 diabetes * attending diabetes clinic in participating centre exclusion criteria: * less than one year since diagnosis * learning disabilities * other medical conditions affecting diabetes management * accommodated by social services

Keywords: diabetes teenagers motivational interviewing
a study to assess the safety and effectiveness of palivizumab administered to children at high risk of severe respiratory syncytial virus (rsv) infection in the russian federation and the republic of belarus

Conditions: Respiratory Syncytial Virus (RSV)

Summary: this is a phase 3b, prospective, multicenter, open-label, non-controlled study to assess the safety and effectiveness of immunoprophylaxis with the intramuscular (im) administration of the liquid formulation of palivizumab for the prevention of rsv hospitalizations in infants at high risk (infants born at less than or equal to 35 weeks gestational age and less than or equal to 6 months of age at enrollment; or infants less than or equal to 24 months of age with a diagnosis of chronic lung disease \[cld\] of prematurity requiring on-going medical treatment within the previous 6 months or infants less than or equal to 24 months of age with hemodynamically significant congenital heart disease \[chd\]).

participants will receive palivizumab solution for injection at 15 mg/kg by im injection every 30 days for a minimum of 3 and a maximum of 5 injections given during anticipated periods of rsv risk in the community; the number of doses will depend on the time of enrollment during the rsv season.

Eligibility criteria:
inclusion criteria: infants at high risk of severe rsv infection defined as fulfilling at least one of the following: * infants born ≤ 35 weeks gestational age and are ≤ 6 months of age at enrollment * infants ≤ 24 months of age at enrollment and with a diagnosis of bronchopulmonary dysplasia (bpd) (defined as oxygen requirement at a corrected gestational age of 36 weeks) requiring intervention/management (i.e., oxygen, diuretics, bronchodilators, corticosteroids, etc.) anytime within 6 months prior to enrollment * infants ≤ 24 months of age at enrollment with hemodynamically significant chd, either cyanotic or acyanotic, unoperated or partially corrected. children with acyanotic cardiac lesions must have pulmonary hypertension (≥ 40 mmhg measured pressure in the pulmonary artery \[ultrasound acceptable\]) or the need for daily medication to manage hemodynamically significant chd exclusion criteria (main exclusion criteria): * hospitalization at the time of enrollment (unless discharge is anticipated within 14 days) * mechanical ventilation (including continuous positive airway pressure, cpap) at the time of enrollment * life expectancy less than 6 months * unstable cardiac or respiratory status, including cardiac defects so severe that survival is not expected or for which cardiac transplantation is planned or anticipated * active respiratory illness, or other acute infection

Keywords: bronchopulmonary dysplasia (bpd) rsv hospitalization palivizumab immunoprophylaxis chronic lung disease (cld) of prematurity
nebulized budesonide for children who are hospitalized for acute wheezing

Conditions: Asthma; Acute Asthma

Summary: the purpose of this study is to determine if adding nebulized budesonide to the systemic steroid for treatment of acute wheezing has any additive benefit in children who have hospitalized for acute wheezing.

context: inhaled steroids reduced admission rates in patients with acute asthma, but it is unclear if there is a benefit of inhaled corticosteroids when used in addition to systemic corticosteroids. there is insufficient evidence that inhaled corticosteroids result in clinically important changes in pulmonary function or clinical scores when used in acute asthma. similarly, it was mentioned in the cochrane database of systematic reviews that further research is needed to clarify if there is a benefit of inhaled corticosteroids when used in addition to systemic steroids. objective: to determine if adding nebulized budesonide to the systemic steroid for treatment of acute wheezing in hospitalized children has any benefit on, symptom score, duration of hospitalization and time to discharge from hospital. study design/setting/participants: a double-blind, randomized, controlled trial of nebulized budesonide versus placebo for children 6 months to 6 years of age who have admitted to the hospital for acute wheezing. intervention: participants will receive standard therapy including scs, albuterol, and ipratropium bromide and will be randomly assigned to also receive either nebulized bis or saline. study measures: differences in asthma scores, vital signs, duration of hospitalization and time to discharge from hospital will be compared between treatment groups.

Eligibility criteria:
inclusion criteria: * children who have recurrent wheezing attacks * children who admitted to the hospital for acute wheezing * clinical asthma score of 3-9 * parental/guardian permission (informed consent) and if appropriate, child assent exclusion criteria: * systemic corticosteroid use in the last 30 days * chronic lung diseases including cystic fibrosis * immunodeficiency * cardiac disease requiring surgery or medications * adverse drug reaction or allergy to budesonide, albuterol, ipratropium bromide, prednisone, prednisolone, or methylprednisolone * known renal or hepatic dysfunction * impending respiratory failure requiring positive pressure ventilation * immune deficiency * gastroesophageal reflux disease * suspected foreign body aspiration or croup * anatomic abnormalities of the respiratory tract

Keywords: wheezing acute asthma children
sleep inducing and maintaining efficacy of circadin in elderly insomniacs

Conditions: Primary Insomnia

Summary: the aim of this placebo controlled study is to investigate the effect of 2 mg melatonin slow release (circadin®) on the sleep/wake cycle in elderly insomniac out-subjects, aged 55 years or more.

circadin® is a newly developed slow release galenic formulation of melatonin, producing overall levels of melatonin comparable to those observed in a control population, when administered to patients with deficiency in melatonin; thus it deserves more clinical and paraclinical investigations for establishing efficacy in inducing and maintaining sleep and for safety. since, on the one hand, the endogenous substance melatonin has beneficial effects on sleep in man and, on the other hand, there is a decrease in melatonin secretion in elderly people, substitution therapy in elderly insomniacs would be a desirable therapy. the aim of this placebo controlled study was to investigate the effect of 2 mg melatonin slow release (circadin®) on the sleep/wake cycle in elderly insomniac out-subjects, aged 55 years or more. sleep was assessed by means of polysomnography (hypnographic results), all-night sleep eeg spectral analysis (functional and quantitative results of sleep eeg), actimetry (somnitortm), wake eeg and sleep/wake quality questionnaires. vigilance and cognitive skills were assessed by means of psychomotor and neurocognitive tests derived from the leeds psychomotor test battery (vigilance and arousal) and tea battery (attention).

Eligibility criteria:
inclusion criteria: * healthy male and female, aged ≥ 55 years, suffering from primary insomnia according to dsm-iv criteria (307.42) exclusion criteria: * according to dsm-iv, subjects belonging to the following groups are excluded: 780.59; 307.45; 307.47; 780.xx (appendix 2); * use of benzodiazepines or other hypnotics during the preceding 1 month with a frequency of more than 2 times a week and lasting more than 2 weeks; * severe neurological, psychiatric or sleep disorders; * other serious diseases; * taking more than 1/2 l of alcohol, more than 3 cups of coffee or more than 10 cigarettes per day . * subjects who need beta blockers as a treatment.

Keywords: insomnia primary insomnia sleep latency non restorative sleep sleep quality double-blind placebo controlled parallel-group sleep laboratory study
effects of mindfulness and yoga on preschool students' emotional regulation, behavior, and social participation

Conditions: Prosocial Behavior; Self Regulation; Impulsive Behavior

Summary: the goal of this clinical trial is to learn if mindfulness and yoga can improve attention, problem-solving, memory, emotional awareness, and impulsivity in preschoolers. the main questions it aims to answer are: can a 30-minute, once-a-week mindfulness and yoga program (calm \& alert) over seven weeks in preschool classrooms increase emotional regulation during the school day? can a 30-minute, once-a-week mindfulness and yoga program decrease negative behavioral incidences during the school day? can a 30-minute, once-a-week mindfulness and yoga program increase prosocial behaviors like caring, sharing, and perspective-taking during the school day? researchers will compare the effects of students who participated in the mindfulness and yoga program to students in classrooms who did not receive the program. student participants will be asked to complete a short self-regulation task test before and after the mindfulness program. teachers will rate the students on their prosocial behavior before and after the mindfulness program and record negative behavioral incidents over the study period.

the current study design is a quasi-experimental pretest post-study design with a control group. three schools with a total of four preschool classrooms will participate in this study. overall, the present research study aims to add to the knowledge base of the benefits of mindfulness and yoga in schools for young children. this will include investigating the effect of mindfulness on children's attention, problem-solving, memory, emotional awareness, and impulsivity. for seven weeks, the intervention group will receive the calm \& alert mindfulness intervention alongside the rest of their class involving one session per week of about 30 minutes of yoga and mindfulness. the control group will conduct business as usual and receive the yoga and mindfulness intervention after the study concludes. the intervention will be provided by the principal investigator who is a certified mindfulness-informed professional and registered yoga teacher - 200 hours. it is hypothesized that implementing a 30-minute, once-a-week mindfulness program over seven weeks in preschool classrooms will increase emotional regulation, decrease negative behavioral incidents, and increase prosocial behaviors during the school day.

Eligibility criteria:
inclusion criteria: * are preschoolers with a filled out and returned parental/caregiver consent form who fall within the four to six-year-old age range, stay within a similar developmental age range, and attend five out of the seven sessions. exclusion criteria: preschoolers without a parental/caregiver consent form, above or below the four to six-year age range will not be included in the study because of the higher variation in developmental capabilities, and if they do not attend five out of the seven sessions. -

Keywords: mindfulness children yoga preschool school-based intervention self-regulation behavioral incident occupational therapy
the effect of telephone education on fear of movement and quality of life in patients with lumbar disc herniation surgery.

Conditions: Spine Disease; Spinal Deformity

Summary: the aim is to quantify the fear of movement and quality of life of telephone education on lumbar disc herniation surgery.

in the randomized controlled study, patients will be randomized into two categories: experimental and control groups. the experimental group will receive intervention via online information for 6 weeks after discharge. the control group will not be given online training other than standard nursing care. at the end of 6 weeks, the difference between fear of movement and quality of life between the two groups will be examined.

Eligibility criteria:
inclusion criteria: * being over 18 years old * knowing how to read and write turkish * no hearing or speech impairment * having lumbar disc herniation surgery for the first time * having a personal cell phone * being discharged 5 days after surgery exclusion criteria: * being under 18 years old * being illiterate * having a hearing and speech disability * not having a personal cell phone * staying in the hospital for more than 5 days after surgery

Keywords: life quality telehealty tele nursing kinezyofobi
comparing early versus elective colonoscopy

Conditions: Acute Lower Gastrointestinal Bleeding

Summary: this multi-center, randomized controlled trial study is planned to include 162 outpatients with onset of acute lower gastrointestinal bleeding to compare the rate of identification of stigmata of recent hemorrhage (srh), and other clinical outcomes, including the 30-day rebleeding rate, between 'early' colonoscopy and 'elective' colonoscopy.

all patients will receive early colonoscopy or elective colonoscopy, but they do so by different timing. early colonoscopy will be performed within 24 h of the initial visit. elective colonoscopy will be performed between 24 and 96 h after the initial visit.

Eligibility criteria:
inclusion criteria: 1. males or females aged ≥ 20 years, presenting with moderate-to-severe hematochezia or melena within 24 h of arrival, defined as (i) more than three occurrences of hematochezia within 8 h, (ii) hemorrhagic shock, or (iii) requiring transfusion. 2. provision of signed and dated informed consent form. 3. stated willingness to comply with all study procedures and availability for the duration of the study. exclusion criteria: an individual who meets any of the following criteria will be excluded from participation in this study: 1. patients with hematemesis, black vomiting, or melena. 2. patients with upper gastrointestinal bleeding, diagnosed by nasogastric tube or upper endoscopy. 3. patients who have impossible consumed the oral bowel preparation solution. 4. patients who have undergone computed tomography. 5. patients who have been diagnosed with peptic ulcer diseases within the previous 10 days. 6. ulcerative colitis or crohn's disease patients. 7. patients who have undergone abdominal surgery within the previous 10 days. 8. patients who have undergone polypectomy, endoscopic mucosal resection, or endoscopic submucosal dissection of the lower gastrointestinal tract within the previous 10 days. 9. patients with suspected perforation or peritonitis. 10. patients with suspected intestinal obstruction. 11. patients with hemorrhagic shock refractory to infusion or blood transfusion. 12. patients who have undergone total colectomy. 13. patients with suspected disseminated intravascular coagulation. 14. patients with end-stage malignant disease. 15. patients with severe cardiac failure. 16. patients with active thrombosis. 17. patients with severe respiratory failure. 18. pregnant patients.

Keywords: early colonoscopy stigmata of recent hemorrhage rebleeding
continuous glucose monitoring for colorectal cancer

Conditions: Continuous Glucose Monitoring; Colorectal Cancer

Summary: hyperglycemia commonly occurs during surgery due to a reaction to metabolic stress and trauma. it has been shown that improper glycemia control leads to impaired wound healing and a higher risk of other postoperative complications. the primary aim of our project is to assess the feasibility of the use of continuous glucose monitoring in measuring blood glucose levels in patients undergoing colorectal cancer surgery. the secondary aim is to analyze changes in perioperative blood glucose levels to understand the effects of stress and intraoperative interventions on the blood glucose level. the tertiary goal is to assess the predictive value of hyperglycemia for surgical site infection.

hyperglycemia commonly occurs during surgery due to a reaction to metabolic stress and trauma. it has been shown that improper glycemia control leads to impaired wound healing and a higher risk of other postoperative complications. however, glucose levels measured in patients before surgery are taken infrequently, and there remains controversy regarding optimal management. usually, a blood glucose meter is used to measure non-fasted blood glucose concentrations, and a single-point measurement can easily misrepresent the actual glycemic control. continuous glucose monitoring allows for a minimally invasive real-time remote glycemia control and is providing insights into glucose regulation in patients, demonstrating significant periods of clinically silent hypoglycemia and hyperglycemia. the primary aim of our project is to assess the feasibility of the use of cgm in measuring blood glucose levels in patients undergoing colorectal cancer surgery. the secondary aim is to analyze changes in perioperative blood glucose levels to understand the effects of stress and intraoperative interventions on the blood glucose level. the tertiary goal is to assess the predictive value of hyperglycemia for surgical site infection.

Eligibility criteria:
inclusion criteria: * written informed consent * confirmed colorectal cancer qualified for surgery exclusion criteria: * patients who will be unable or will refuse to express informed concern * pregnant women * people undergoing dialysis treatment

Keywords: cgm colorectal cancer continuous glucose monitoring