Kornimate/medical-research-clean huggingface dataset:
study comparing two alternatives of antiretroviral therapy as post-exposure prophylaxis to hiv-1:fovir+emtricitabina + lopinavir/ritonavir vs tenofovir+emtricitabina + maraviroc (maravi-pep)

Conditions: HIV Infection

Summary: as a measure of secondary prophylaxis, and with the final objective of avoiding the infection, it has been suggested to use antiretroviral therapy. this is known as post-exposure prophylaxis (pep). although there are different recommendations, almost every guideline recommend using 3 drugs as pep both in usa and europe. toxicity is one of the main limitations of pep. side effects during pep are very usual, are attributed mainly to pi and are the main reasons for poor adherence or lost of follow-up. a current standard regimen is azt+3tc (combivir®) or tenofovir+emtricitabine (truvada®) plus the pi lopinavir/r. toxicity associated with this regimens are high (31-85% of cases), with a 10-35% interruption of pep maraviroc, a ccr5 receptor antagonist, very well tolerated, coul be an adequate drug for pep.


Eligibility criteria:
inclusion criteria: * both sexes * older than 18 years old * a potentially sexual exposition to hiv * accept to participate exclusion criteria: * pregnant women * the source case a person with hiv antiretroviral resistances * persons with a treatment that is contraindicated with the drugs in the study

Keywords: hiv infection postexposure prophylaxis
physical activity, air pollution, and high blood pressure

Conditions: Essential Hypertension

Summary: the investigators are investigating the effects of traffic-related air pollution (trap) on the cardiovascular and pulmonary response to exercise in patients with hypertension using a real world randomized, crossover study design. participants will be exposed to 2 conditions: a low trap environment and a high trap environment. each exposure will consist of 30 min of moderate-intensity exercise. cardiovascular and pulmonary health outcomes will be measured before, during, and up to 24 hours following exposures. a minimum washout period of 1 week will be used to minimize carryover effects.


Eligibility criteria:
inclusion criteria: 1. age between 40-70 years of age 2. previously diagnosed with elevated blood pressure or hypertension by a physician exclusion criteria: 1. current or ex-smokers (abstinent for less than one year) 2. lives with an individual who currently smokes cigarettes, e-cigarettes (i.e., vaping), or cannabis 3. hormone replacement therapy use 4. currently on beta-blocker or angiotensin receptor blocker (arb) therapy 5. currently using over the counter drugs or supplements that may alter cardiovascular measures (as per the principal investigator's discretion) 6. prior diagnosis of any other existing cardiovascular or pulmonary diseases and/or conditions (other than hypertension) 7. musculoskeletal injury or lower limb limitation preventing safe engagement in moderate-intensity exercise

Keywords: traffic-related air pollution physical activity exercise blood pressure heart rate variability arterial stiffness microvascular responsiveness muscle oxygen saturation lung function
new foods take time, a curriculum designed to promote tasting and liking of fruits and vegetables

Conditions: Eating Behavior

Summary: the overall objective of this project is to conduct a preliminary evaluation of the "new foods take time" intervention in head start preschool classrooms.

the overall objective of this project is to conduct a preliminary evaluation of the "new foods take time" intervention. this curriculum is designed to increase children's preference for and consumption of fruits and vegetables (fv) by encouraging children to try new fv and repeatedly taste these foods.

Eligibility criteria:
child inclusion criteria: * enrolled in a head start preschool center * between the ages of 2 and 5 years old child exclusion criteria: * food allergy or restriction to foods in the tastings parent inclusion criteria: * parent or primary caregiver of a child enrolled in the study * age 18 years or older * english speaking parent exclusion criteria: * none teacher inclusion criteria: * actively employed as an early childhood education provider in the head start classroom where the intervention is delivered * age 18 years or older teacher exclusion criteria: * none

Keywords: fruits vegetables food neophobia preschool children
effect of periodized resistance training and high intensity training on bmi and qol in pcos

Conditions: Polycystic Ovary Syndrome

Summary: this study may help to improve strength and body composition in females with pcos. it will enhance ability of an overweight individual to perform functional tasks (i.e. daily living tasks or physical activity) to be physically active. this may facilitate the adoption of a more active lifestyle, thereby increasing the likelihood of success in overall weight-reduction strategies.

poly cystic ovarian syndrome (pcos) is a hormonal disorder which is most common in females with fertile age. a number of small fluid filled sacs formed in ovaries which results in failure of egg release. poly cystic ovary syndrome (pcos) is an endocrine problem which is characterized by the polycystic ovaries, menstrual problems, infertility, metabolic disorder, psychological problems, elevated androgens, hirsutism, acne and obesity. pcos also causes psychological disorders which include depression, anxiety, poor body image, low self-esteem and decreased health- related quality of life. some well-controlled randomized clinical studies have been conducted to evaluate the effects of exercise training program in women with pcos. there are many beneficial effects of exercises which improve physical fitness, body composition, and cardiovascular, hormonal, reproductive and psychological outcomes. periodization training program involves period of active rest which allows muscle adaptations through variable intensity, volume and rest. the advantage of periodization is that it prevent from overtraining symptoms such as muscle stiffness, muscle soreness, sprain, strain, possible injury and decreased performance. high intensity interval training is effective in reducing body mass index and improving body composition in females with pcos. the study will be a randomized clinical trial and will be conducted in mohsin memorial hospital faisalabad. this study will be completed in time duration of ten months after the approval of synopsis and convenient sampling technique will be used. total twenty four subjects will be assigned randomly by using lottery method into two groups. group a will receive periodized resistance training and group b will receive high intensity interval training. warm up and cool down period of ten minutes of treadmill training will be performed by both groups. data will be collected from all participants at baseline and after 8 weeks of treatment by using bmi and who-qol bref questionnaire. after assessing the normality data will be analyzed by using parametric or non-parametric test by using spss-25.

Eligibility criteria:
inclusion criteria: * age between 20-35 years * unmarried females * diagnosed patients of pcos * all women who are less physically active or have sedentary life style. * bmi\>25kg/m2 (overweight obese) exclusion criteria: * use of hormonal contraceptives. * diabetes * hypertension * thyroid disease * cushing disease * any physical disability
strict glucose control of pediatric intensive care unit (icu) patients

Conditions: Respiratory Failure; Cardiovascular Failure; Sepsis; Trauma

Summary: the study objective is to improve morbidity and mortality of high-risk critically ill children. our hypothesis is that a strict icu glucose control protocol will decrease morbidity and mortality associated with hyperglycemia in a population of high-risk critically ill pediatric patients.


Eligibility criteria:
inclusion criteria: * vasoactive infusion (e.g. dopamine, epinephrine, norepinephrine) and/or * invasive mechanical ventilation * age between 1 mo and 21 yrs exclusion criteria: * type i diabetes mellitus * have an illness that requires insulin daily * recipients of solid organ transplants * participation in an experimental trial that might affect outcome * post-operative patients with planned extubation upon recovery * patients on a dopamine infusion of less than 3 mcg/kg/minute
use of topical lidocaine to reduce pain in preterm infants receiving nasal cpap continuous positive airway pressure

Conditions: Other Preterm Infants

Summary: the main purpose of this study is to evaluate the relative efficacy of topical lidocaine on reducing pain associated with the application of nasal cpap in preterm infants

preterm infants admitted to nicus are exposed to a range of painful procedures. the exposure to pain during this critical of brain development may have adverse consequences. application of nasal cpap is one of the painful procedures. a consensus statement on neonatal pain made recommendations for analgesia for neonatal procedures. topical lidocaine is frequently used as a topical anesthetic during venipuncture, heel lancing, circumcision, endotracheal intubations, nasogastric tube insertion, endoscopy and bronchoscopy. however, the use of topical lidocaine for its analgesic effect on application of nasal cpap has not been evaluated. this study proposes a randomized controlled trial to evaluate the relative efficacy of topical lidocaine on reducing pain associated with the application of nasal cpap in preterm infants.

Eligibility criteria:
inclusion criteria: * preterm infants \< 37 weeks gestation * admitted to nicu, mansoura university children's hospital * respiratory distress requiring use of nasal cpap * informed consent obtained exclusion criteria: * serious, life-threatening malformations * use of sedation, analgesia in the preceding 72 hours * those who undergo any surgical intervention * those who undergo any painful procedures as venipuncture, intubation, suctioning, blood sampling, heel-prick, catheterization 30 minutes before assessment * those with signs of nasal injuries at the time of application of ncpap * necrotizing enterocolitis

Keywords: topical lidocaine nasal cpap pain preterm infants salivary cortisol
spica cast duration for ddh

Conditions: Dysplasia; Hip

Summary: this study looks at treatment for developmental dysplasia of the hip (ddh), a condition where there is abnormal development of a child's hip joint. while spica casts are shown to very effective in treating ddh, and potentially more effective than hip braces alone, other research shows that the outcomes from braces are equivalent to those of spica casts with the added advantage of greater patient satisfaction and less burden on families. therefore, the 12-week experimental protocol in the study, with the first 6 weeks involving the spica cast and the second 6 weeks the hip brace, was designed to determine if both treatment methods can be combined for an optimal patient experience.

the primary objective of this study is to compare the clinical outcomes of patients who undergo closed reduction of a developmentally dysplastic hip and are treated with six weeks of supplemental casting to those treated with twelve weeks of supplemental casting. the secondary objectives of this study are to determine if a shorter duration of postoperative casting affects family satisfaction and costs compared to the traditional pathway (12 weeks of spica casting). the physician will meet with the patients during the regular standard of care follow-ups every 2-3 weeks to track patient progress. following 6 weeks of recovery, the control group will have their spica cast replaced in the operating room, with the child anesthetized, by another cast for 6 weeks. the experimental group will have their cast removed in the clinic without anesthesia and will be placed into a full-time brace for 6 weeks. participants will be instructed to complete the full 12 weeks of the protocols. only patients who complete the full length of treatment in either group will be considered for the study. the physicians will keep track of patients during visits to ensure the protocols are being followed.

Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form * stated willingness to comply with all study procedures and availability for the duration of the study * diagnosed with ddh * require closed reduction of the hip and hip spica casting 1. between 6-18 months old 2. alpha angle \ 55 degrees i. alpha angle is an angle created by lines along bony acetabulum and the ilium, normal is \>60 degrees ii. beta angle is an angle created by lines along the labrum and ilium, normal is \<55 degrees c.have either failed pavlik harness or have dislocated hip on imaging exclusion criteria: * patients over the age of 18 months * patients with ddh who do not require closed reduction surgery * patients with ddh who are initially consented for closed reduction surgery but their intraoperative findings necessitate conversion to open surgery * families that do not want to participate in the study * patients with dysplasia that need open reduction
comparison of biodegradable and titanium fixation systems in mandibular symphysis or parasymphysis solitary fractures

Conditions: Mandible Fracture; Rigid Internal Fixation; Three-dimensional Finite Element

Summary: the mandible bears a wide range of mechanical load from the contraction of masticatory muscles, and has a significant function in normal chewing movements. mandibular fractures are the most common maxillofacial fractures, accounting for 40%-71% of all maxillofacial fracture cases with an average of 62%. the etiology of mandibular fractures mainly includes assaults, road traffic accidents (rtas), falls, and sports injuries. although a wide variance exists in the reported percentage of anterior mandible fractures, aggregate analysis approximates these fractures at 17% of all mandibular fractures. the rigid internal fixation (rif) technique has become a common treatment for mandibular fractures, in which titanium plates are used in the operation. some patients have to remove the titanium plates in a second operation following bone healing because of sequelae, such as stress shielding. biodegradable plates and screws have been developed to eliminate the problems associated with titanium fixtures. in this study, we aim to compare the clinical performance between biodegradable and titanium fixation systems after 12 months of follow-up in fixation of mandibular symphysis and parasymphysis solitary fractures. we also investigate the stress distributions of biodegradable and titanium fixation systems at mandibular symphysis solitary fracture on the conditions of intercuspal position, labial teeth occlusion, and premolar and molar occlusion using finite element analysis.


Eligibility criteria:
inclusion criteria: * undisplaced and displaced mandibular symphysis and parasymphysis solitary fractures conducted at the department of oral and maxillofacial (omf) surgery, tianjin medical university general hospital exclusion criteria: * the exclusion criteria were comminuted fractures * diabetes * connective tissue diseases * patients under the age of 18 and over the age of 60
tau brain imaging in typical and atypical alzheimer's disease (ad)

Conditions: Alzheimer Disease; Benson's Disease

Summary: recently revised alzheimer disease (ad) diagnostic1described nonamnestic presentations: 1/ language presentation (logopenic progressive aphasia) 2/ visuospatial presentation (posterior cortical atrophy or pca) and 3/ executive dysfunction. ad pathological changes may precede the clinical diagnosis of dementia of ad type for a while2. biomarkers have been developed: biomarkers of brain amyloid-beta (aß) (cerebrospinal fluid csf concentration ßamyloid, molecular imaging with amyloid targeted pet ligands), biomarkers of neural degeneration (mri hippocampal volume, regional metabolism as assessed by pet with \[18f\]-fdg) and may be used to made early detection of the neuropathology associated with ad even if csf biomarkers (tau, p-tau and β amyloïd are interesting to improve diagnosis of ad, they cannot provide topographic information. pet tau imaging seems to be promise to evaluate quantitative and spatial assessment of tau lesions both in ad and fronto-temporal lobar dementia. the hypothesis of the research is that it exists a different regional pattern of tracer retention across brain regions according to clinical symptoms : temporal for logopenic aphasia and occipital for posterior cortical atrophy.


Eligibility criteria:
inclusion criteria: * 50 years old and more * native langage: french * study level upper (or equal) than 7 year (considering first year of grammar-school as start) * correct sensory abilities (auditive device allowed) for tests * affiliation to social security * informed, written consent form * for alzheimer disease group: people with alzheimer disease defined as national institute of neurological and communicative disorders and stroke (nincds) and the alzheimer's disease and related disorders association (adrda) standards: light to mild ad defined by mini-mental state examination (mmse) score between 15 and 25 (included) * for benson disease group: benson disease following mendez et al (2002) and tang wai et al (2004) criteria * for healthy volunteer group: normal mms score (more than 26 for bachelor level) exclusion criteria: * history of disease with consequances on cognitive functioning (tumor, stroke, head trauma, etc.), cerebral surgery * use of alchohol and/or drug * anormalies in neurological exam (focal deficit) not included in the classic symptoms * contraindication to magnetic resonance imaging (rmi) * contraindication to pet: people with prolongation of qt interval or taking medication that can lead to "torsades de pointe". * claustrophobia * person with legal protection * exclusion period because of participation to another experimental protocol and actual participation to an experimental protocol * pregnant or lactating woman or able to procreate and without contraception
enhancing medication-based analgesia in humans- study 2

Conditions: Pain; Cannabis; Opioid Use

Summary: this is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the fda-approved cannabinoid cannabidiol (cbd; epidiolex) would enhance analgesia, subjective reports, and cognitive performance when compared to the fda-approved opioid hydromorphone (dilaudid). this is study 2 is a series of studies.

this was a human laboratory systematic examination of whether adding the fda-approved cannabinoid cannabidiol (cbd; epidiolex; oral) to the fda-approved opioid hydromorphone (dilaudid; oral) would change the experience of hydromorphone as rated by laboratory measures of pain, subjective reports of drug effects, and cognitive performance. subjects are healthy individuals with no history of drug use disorder. study subjects and staff were completed blinded to the study drugs and the class of drugs under investigation and were informed that subjects may receive opioids, stimulants, cannabinoids, benzodiazepines, over the counter medications, and/or placebo. all participants completed all sessions. sessions lasted up to 8-hours and were conducted at least 7 days apart on an outpatient basis. primary outcomes were collected from participants prior to dosing and at several hour periods post-dosing.

Eligibility criteria:
inclusion criteria: * aged 18-75 * urine sample tests negative for common illicit substances of abuse, including cannabis * medically cleared to take study medications * are not pregnant or breast feeding * willing to comply with the study protocol. exclusion criteria: * meet dsm-5 criteria for alcohol/substance use disorder * taking opioids for pain * previous adverse reaction to a cannabinoid product * prescribed and taking stimulants or benzodiazepines * answer "yes" to item 1 of the brief pain inventory indicating chronic pain * self-report any illicit drug or cannabinoid use in the past 7 days * presence of any clinically significant medical/psychiatric illness judged by the investigators to put subject at elevated risk for experiencing an adverse event * history of seizure disorder * have a known allergy to the study medications or sesame seed oil * alt or ast levels \>3x uln and/or bilirubin levels \>2x uln during screening * current (past 60-day) suicidal thoughts or past year history of suicidal behavior * taking medications contraindicated with hydromorphone or cannabidiol * have a history of clinically significant cardiac arrhythmias or vasopastic disease * have an abnormal and clinically-significant ecg

Keywords: clinical trial analgesia phase ii abuse potential
the prevalence of lung cancer in patients with interstitial lung disease

Conditions: Lung Diseases, Interstitial; Lung Cancer

Summary: the investigators will evaluate the prevalence of lung cancer associated with interstitial lung disease (ild) and idiopathic pulmonary fibrosis (ipf) utilizing the korean health insurance review and assessment service (hira) database, spanning the period from january 2011 to december 2011. the database (hira-nps-2011-0001) was based on random sampling of outpatients from whole population. patients with ilds, ipf, connective tissue disorder (ctd), and copd were identified based on the international classification of disease-10 (icd-10) diagnostic codes.

the epidemiology of lung cancer related to interstitial lung disease (ild) with or without with connective tissue disease (ctd) as well as idiopathic pulmonary fibrosis (ipf) has not been well established yet. interstitial lung disease has a potential to develop lung cancer in the name of scar cancer. the investigators aimed to explore prevalence of lung cancer in patients with ild with or without ctd and ipf in comparison with chronic obstructive pulmonary disorder (copd). the investigators will evaluate the prevalence of lung cancer associated with ild and ipf utilizing the korean health insurance review and assessment service (hira) database, spanning the period from january 2011 to december 2011. the database (hira-nps-2011-0001) was based on random sampling of outpatients from whole population. the sample cases are total 1,375,842. among them 670,258 cases (age \> 40) were evaluated. patients with ilds, ipf, ctd, and copd will be identified based on the international classification of disease-10 (icd-10) diagnostic codes.

Eligibility criteria:
inclusion criteria: * equal to above 40 years old exclusion criteria: * none