Kornimate/medical-research-clean huggingface dataset:
evaluation of saliva and serum heme oxygenase, arylesterase and nuclear factor erythroid 2-related factor 2 levels in patients with stage iii periodontitis

Conditions: Periodontal Health; Periodontitis Stage III

Summary: periodontal disease is a chronic and progressive inflammatory disease in which the hard and soft tissues that support the teeth are damaged. it is caused by the interaction between harmful bacteria and the body's immune responses, and most periodontal tissues are damaged by the body's abnormal response to these microorganisms and their products. when bacteria enter the body, immune cells (neutrophils) produce reactive oxygen species (ros) in a process called the "respiratory burst". these ros damage cells, causing tissue destruction through a variety of mechanisms, including dna damage, fat oxidation and protein damage. studies have shown that neutrophils from individuals with periodontal disease produce more ros than neutrophils from healthy individuals. high amounts of ros lead to oxidative damage to gum tissue, periodontal ligament and alveolar bone. oxidative stress occurs when antioxidants in the body are insufficient or when high levels of ros are present. therefore, disruption of the balance between oxidant and antioxidant activities is considered an important cause of oxidative damage in periodontal tissues. parameters such as total antioxidant status (tas), total oxidant status (tos) and oxidative stress index (osi) are used to determine oxidative stress. furthermore, some enzymes such as arylesterase (are), heme oxygenase (ho) and nuclear factor erythroid 2-related factor 2 (nrf-2) are involved in defense mechanisms against oxidative stress. many recent studies have shown a strong association between oxidative stress and periodontal disease.

this study was divided into 2 groups, 37 systemically and periodontally health individuals and 37 systemically healthy individuals with stage iii grade b periodontitis were included. clinical periodontal parameters plaque index (pi), gingival index (gi), probing pocket depth (scd), bleeding on probing (bop) and clinical attachment level (cal) were recorded and saliva and serum samples were collected. elisa method was used for analyses of tos, tas, osi, are, ho-1, nrf-2 levels.

Eligibility criteria:
inclusion criteria: * systemically healthy * between the ages of 18-65 exclusion criteria: * patients with systemic diseases and/or conditions that may affect periodontal tissues (cardiovascular diseases, immune system diseases, rheumatoid arthritis, diabetes mellitus, chemotherapy/radiotherapy). * taking any medication that may have an effect on periodontal tissues, * less than 20 natural teeth excluding third molars * used antibiotics, anti-inflammatory or immunosuppressive drugs * periodontal treatment in the last 6 months * smokers * pregnant or lactating women.

Keywords: total antioxidan status total oxidan status oxidative stress index arylesterase heme oxygenase nuclear factor erythroid 2 related factor 2 saliva serum stage iii periodontitis
evaluation of trastuzumab in patients with her2 positive persistent or recurrent vulvar paget's disease

Conditions: Paget's Disease of the Vulva

Summary: this is a phase ii open-label study of the activity and safety of trastuzumab in patients with vulvar paget's disease with overexpression of her2 on biopsy.

the primary objective will be to estimate the anti-tumor activity of trastuzumab by evaluating the response to trastuzumab therapy in patients with recurrent or persistent vulvar paget's disease demonstrating her2/neu overexpression by immunohistochemistry and/ or fish ((fluorescence in situ hybridization). the secondary objectives: * to evaluate the quality of life, based on the severity of the patients' vulvar itching on a 4-point verbal rating scale from 0 to 3 (0=no itching, 1=mild itching/ bothersome, 2=moderate itching/ troublesome, 3=severe itching/ extremely troublesome) as well as on the severity of the patients' vulvar pain on a numeric pain scale from 0-10 (0=no pain, 1-3=mild pain, 4-6=moderate pain, 7-10=severe pain). * to assess the frequency and severity of observed adverse effects * to assess the frequency/ incidence of her2 in paget's disease of the vulva

Eligibility criteria:
inclusion criteria: * recurrent or persistent vulvar paget's disease with overexpression of her2 by immunohistochemistry and or fluorescence in situ hybridization (fish) * biopsy for histologic confirmation * measurable disease * karnofsky score of 50-100 * recovered from effects of recent surgery, radiotherapy, or chemotherapy * free of active infection requiring antibiotics * adequate bone marrow function,renal function,hepatic function,cardiac function,wocbp-neg.serum pregnancy,meet requirements in section 7.0 exclusion criteria: * no measurable disease * tumors not her2 positive by immunohistochemistry fish * prior therapy with any anti-her2 monoclonal antibody preparation * karnofsky score of 0-40 * other invasive malignancies, with the exception of non-melanoma skin cancer * patients requiring supplemental oxygen * unstable medical conditions in the opinion of the treating physician place them at unacceptably increased risk from trastuzumab therapy * patients with active or unstable cardiac disease, or myocardial infarction within 6 months

Keywords: her2+ histologic confirmation measurable disease her2 positive her2 overexpression persistent vulvar paget's disease recurrent vulvar paget's disease
the effect of variety on physical activity

Conditions: Overweight

Summary: increasing physical activity continues to be a challenge among many individuals, particularly those who are overweight. recent data from the national health and nutrition examination survey (nhanes) showed that individuals who reported engaging in a variety of activities were more likely to meet national physical activity recommendations compared to those who reported no variety. incorporating a variety of activities into a physical activity program may be a way to increase physical increase physical activity levels. one method to increase variety in physical activities is to use active videogames. videogames that use motion sensors allow a gamer to physically perform a variety of activities. thus, the purpose ot this laboratory-based investigation is to conduct a study to examine the effect of engaging in a greater variety of active videogames on energy expenditure in 30 non-obese, regularly active adults.

thirty men and women, aged 18- to 35- years, recruited from the local area, with a normal body mass index (bmi) between 18.5 and 29.9 kg/m, will participate in two experimental sessions, variety and non-variety, with order of experimental sessions counterbalanced across participants. participants will be assessed on liking of the active videogames, energy, tiredness, motivation, to succeed, interest in the games, and energy expenditure during the experimental sessions.

Eligibility criteria:
inclusion criteria: * men and women, ages 18-25 years are eligible to participate. they will be recruited from flyers posted around campus and in local gyms, and must be willing to participate. they must have a body mass index (bmi) between 18.5 and 29.9 kg/m2. exclusion criteria: * participants who have never played an active videogame or are unable to play an active videogame. if the participant dislikes (scoring \<50 on a 100 mm visual analogue scale \[vas\]) playing the active videogames used in the investigation. or if the participant engages in less than 150 minutes/week of moderate- to vigorous-intensity physical activity over the previous month.

Keywords: active video games energy expenditure
randomized wad study

Conditions: Whiplash Symptoms

Summary: background: the majority of patients suffering a whiplash injury (wad) will recover, but some may have symptoms for years despite all kinds of conservative treatment. the neck pain task force (2008) found no existing evidence for positive effects of fusion operations in such patients. some of them, however, present with symptoms that might indicate pain from a motion segment, possibly the disc. our aim was therefore to test this possibility by performing a randomized study comparing cervical fusion and multimodal rehabilitation in chronic wad patients. methods: patients with a specified symptomatology, all with pronounced symptoms for long periods of time, were recruited and randomized to surgery (25 pat.) or to multimodal rehabilitation (24 pat.). all patients were investigated before start of the study and at follow-up approximately two years after treatment by four independent examiners from disciplines usually involved in treating wad patients. the patients also gave their own assessments of the treatment results. seven patients in each group did not undergo the allocated treatment for various reasons.

outcomes: representing different disciplines: neurology, orthopedics, physical medicine and psychology. each patient´s perceived change in outcome was also assessed. assessment was made before treatment and at follow-up two years afterwards. in addition to the assessments of outcome made by the examiners, the patients completed the sf-36, eq-5d and bis (balanced inventory for spinal disorders) questionnaires before treatment and at follow-up. the results of these assessments will be given in a forthcoming paper. 6b. no changes in trial outcomes were made during the study.

Eligibility criteria:
inclusion criteria: * the patients were to have been involved in a traffic accident as the origin of their pain and to have had pronounced symptoms lasting for at least one year. * they should be in the age group 18 to 60 years, * have been actively working up until the accident, * should not have had previous neck pain. * all patients should have had a plain x-ray and an mri showing no specific changes. * the patients should present with pronounced neck pain with the origin in the midline. * the character of the pain should be dull, aching, and, with sudden movements, stabbing in the same area. * palpation and pressure in that area should provoke deep pain.. exclusion criteria: - previous pain in the neck, previous surgery

Keywords: whiplash, surgery, multimodal rehabilitation, independent examiners
prophylactic tamsulosin use for prevention of post-operative urinary retention

Conditions: Post-Operative Urinary Retention

Summary: this randomized open-label study will be comprised of 2 cohorts: one control group and one treatment group. the trial will be conducted as an open label randomized trial to evaluate the efficacy of tamsulosin in the prevention of post-operative urinary retention. the study will include pre- and post-surgical evaluations of patients including symptoms of urinary retention and any adverse effects contributable to the study medication.


Eligibility criteria:
inclusion criteria: * any male age 40 or older * scheduled to undergo one of the planned surgeries (thoracic, general, or urologic) * ability to give informed consent exclusion criteria: * current use of alpha blocker * current use of a strong cyp 3a4 inhibitors * any allergy to tamsulosin, alpha-blocker medication class, or anaphylaxis allergy to sulfate containing medications * patients with any upcoming surgery for cataracts * currently enrolled in a clinical trial * inability to give informed consent

Keywords: post-operative urinary retention
efficacy of amygdala retraining with mindfulness (art+mf) vs compassion therapy (ct) for the treatment of patients with fibromyalgia

Conditions: Fibromyalgia

Summary: amygdala retraining treatment (art) is a new and promising therapy for patients with chronic fatigue syndrome (cfs) and fibromyalgia (fm), however, randomized controlled trials (rct) are scarce. the investigators have added mindfulness to this therapy, based on preliminary reports of its efficacy on patients, obtaining amygdala retraining treatment with mindfulness (art+mf). other therapy that has been assessed in many psychiatric and medical disorders during the last years has been compassion therapy (ct). there are no studies on its efficacy in fm. aims: the aim of this trial is to assess the efficacy of both art+mf and ct on the general function of the patients with fm. a secondary objective is to assess the effect of these therapies on psychological (pain, depression, anxiety, etc.) and biological variables (some biomarkers related with inflammation). methods: * design: randomized, controlled trial with three arms: a) art+mf, b) ct and c) relaxation as control intervention. * sample: a sample (n=60 patients, about n=20 for each arm) will be recruited from primary care settings at the city of zaragoza, spain.


Eligibility criteria:
inclusion criteria 1. male or female aged between 18-65 years. 2. the patient needs to have the ability to read and understand spanish 3. all the patients included in the study have been diagnosed with fm by a rheumatologist working for the spanish national health service. 4. it is required that the patient does not modify during the trial the pharmacological treatment prescribed. 5. signed informed consent. exclusion criteria the patient should not meet any of the following criteria during the study: 1. age \ 65 years. 2. the patients considered for exclusion are individuals with severe axis i psychiatric disorders (dementia, schizophrenia, paranoid disorder, alcohol and/or drug use disorders) and with severe somatic disorders that, from the clinician's point of view, prevented patients from carrying out a psychological assessment or participating in other clinical trials 3. it is not considered an exclusion criterion antidepressant use, as long as the treatment is not modified during the study period (treatment can be decreased, never increased).
bedside ultrasound identifies congestive heart failure

Conditions: Heart Failure; Dyspnea

Summary: patients often arrive to the emergency department with the chief complaint of shortness of breath. the cause of the shortness of breath may be due to many things, such as pneumonia, emphysema, a heart attack, heart failure, and others. it is often very difficult for the physician to determine the cause of the shortness of breath in the first two hours in the emergency department. this ambiguity makes treating the patient very difficult. although a patient could benefit from treatment upon arrival, the emergent treatment of the condition must wait until a final diagnosis is made. recently, emergency physicians have been using portable ultrasound at the patient's bedside to diagnose numerous conditions, including trauma, blood clots, kidney stones, etc. recent research suggests that heart failure, one of the causes of shortness of breath, may be diagnosed within 5 minutes or less using ultrasound. most of these studies come from the intensive care and cardiology. however, no research has yet been performed to determine if emergency physicians can effectively use ultrasound to quickly diagnose and treat heart failure within the first few minutes of a patient's arrival to the emergency department. the hypothesis of this study is to evaluate the ability of residents in emergency medicine to use ultrasound to diagnose patients in heart failure who presented with the chief complaint of shortness of breath. the final diagnosis of the patient upon discharge from the hospital will be compared to the preliminary diagnosis based on the portable ultrasound findings.


Eligibility criteria:
inclusion criteria: * age \> 18 * presenting complaint of shortness of breath or dyspnea exclusion criteria: * prisoners * pregnant women * shortness of breath clearly secondary to another diagnosis (i.e. trauma)

Keywords: heart failure dyspnea ultrasound
chronic pain after operation for breast cancer

Conditions: Pain Threshold

Summary: the purpose of this study is to identify intraindividual as well as iatrogenic factors disposing for the development of chronic and acute pains after surgery for breast cancer in order to improve treatment and prevent the development of acute and chronic postoperative pains.

surgery for breast cancer is followed by acute undesirable sequelae (pain, nausea, vomiting, psycho-social adaptation) and late sequelae with discomfort or more severe neuropathic pain problems in the surgical area due to nerve damage or adjuvant-/radiotherapy. the late sequelae occur in 30-50% of patients but the exact mechanisms (preoperative disposing factors, intraoperative nerve damage/inflammatory response), acute postoperative pain and psychosocial factors remain to be determined in large, detailed, well-described studies, including stratification to modern breast cancer treatment (sentinel node strategy/ radiotherapy/ chemotherapy). the present study will describe in detail preoperative psychosocial/genetic pain mechanisms, intraoperative technique, multi-modal anaesthesia and opioid-reduced analgesia with a detailed, early and late postoperative follow-up with neurophysiological assessment in the surgical area and randomised studies on preventive therapy.

Eligibility criteria:
inclusion criteria: * healthy women exclusion criteria: * pregnancy * lactating

Keywords: reference values sensory thresholds pain threshold breast neoplasms
radioembolisation and chemotherapy in liver metastatic breast cancer patients

Conditions: Liver Metastases; Breast Cancer

Summary: the goal of this multicentre clinical pilot study is to investigate the feasibility of the addition of ho-166 radioembolization to chemotherapy in patients with liver metastastic breast cancer. participants will receive a mapping angiography and ho-166 radioembolization. chemotherapy will be stopped 2-5 prior to radioembolization and continuation of chemotherapy will be evaluated at 2 weeks post-radioembolization.


Eligibility criteria:
inclusion criteria: * women \>18 years * patients with hormone positive and her2 negative liver metastatic breast cancer * no extra-hepatic disease progression at evaluation of at least second line systemic chemotherapy * suitable for tare evaluated after the mapping angiography * measurable target tumors in the liver according to recist 1.1 * liver tumor burden \<50 % * ecog performance score 0 to 1 * laboratory parameters: neutrophils \>1000/μl; thrombocyte count \>1000000 μl; egfr \>45/ml/min/1.73 m2; albumin \> 3.0 g/dl, bilirubin \< 1.5x uln (unless gilbert syndrome); aminotransferase (alat/asat) \<3.0 uln * able to read dutch exclusion criteria: * life expectancy ≤3 months * patient eligible for other curative local liver therapy (ea. surgery, ablation) * brain, pleural, peritoneal or extensive extra-hepatic visceral metastases * other life-threatening disease (i.e. dialysis, unresolved diarrhea, serious unresolved infections (hiv, hbv, hcv etc.)) * contraindication for angiography or mri * significant toxicities due to prior cancer therapy that have not resolved before the initiation of the study, if the investigator determines that the continuing complication will compromise the safe treatment of the patient * prior or planned embolic intra-arterial liver directed therapy (tace, tae, tare) * prior or planned external or internal radiation therapy of the liver * cirrhosis or portal hypertension * main portal vein thrombosis * intervention for, or compromise of, the ampulla of vater * ascites (except minor focal ascites) * baseline use of analgesics for abdominal pain * pregnancy (women at childbearing potential need at least one form of birth control) and breastfeeding * flow to extra hepatic vessels not correctable by reposition or embolization * estimated dose to the lungs greater than 30 gy in a single administration or 50 gy cumulatively * target tumoral absorbed dose of \ 50gy (in case of whole liver treatment)

Keywords: liver metastatic breast cancer holmium-166 radioembolization tare sirt selective internal radiotherapy
pain phenotypes in chronic pancreatitis

Conditions: Chronic Pancreatitis

Summary: chronic pancreatitis (cp) is characterised by recurrent abdominal pain. the pathological hallmarks of cp is pancreatic stellate cell activation that results in persistent inflammation and progressive fibrosis. it has been shown in various clinical and experimental studies that with disease progression there could be pancreatic neural inflammation, spinal sensitization and eventually alteration in the pain modulating architecture within the brain (widespread sensitization). these events result in different types of pain (nociceptive and neuropathic) in patients with cp, which may dynamically change during disease progression. since the treatment for different mechanisms are unique, it becomes important to identify the predominant type of pain. recently, pancreatic quantitative sensory testing (p-qst) has emerged as a valuable tool to identify different types of sensitization. this facility is currently available only in select centers and is being conducted under research protocols. in this study, we propose to: 1. evaluate the patterns of pain in cp and the triggers; 2. identify clinical surrogates of sensitization, i.e. neuropathic pain. the ultimate goal is to apply the best possible pain management strategy based on our research findings for patients with cp in a personalised manner.


Eligibility criteria:
inclusion criteria: * at least 3 years of disease (chronic pancreatitis) * both genders * able to provide informed consent exclusion criteria: * acute exacerbation of chronic pancreatitis * moderate to severe abdominal pain at the time of screening * pancreatic cancer or other malignancies * use of antidepressants, narcotics, and neuromodulators
the effect of hmg-coa reductase inhibition on postprandial glp-1 secretion

Conditions: Diabetes Mellitus, Type 2; Hydroxymethylglutaryl-CoA Reductase Inhibitors

Summary: the primary objective of the present study is to evaluate the effect of hmg-coa reductase inhibition during 14 days on the postprandial plasma glp-1 response in healthy individuals. secondary objectives include the evaluation of hmg-coa reductase inhibition on postprandial glucose tolerance, gallbladder emptying, gastric emptying, plasma responses of lipids, bile acids and pancreatic and enteric hormones known to influence glucose metabolism and appetite, and faecal content of bile acids and gut microbiota composition.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) \>18.5 kg/m2 and \<35 kg/m2 * caucasian ethnicity * normal haemoglobin * glycated haemoglobin (hba1c) \<43 mmol/mol * fasting plasma glucose \<6 mmol/l * informed and written consent exclusion criteria: * diabetes * first-degree relatives with diabetes (both type 1 diabetes and type 2 diabetes) * liver disease (serum alanine aminotransferase (alat) and/or serum aspartate aminotransferase (asat) \>2 times normal values) or history of hepatobiliary disorder * gastrointestinal disease, previous intestinal resection, cholecystectomy or any major intra-abdominal surgery * reduced kidney function or nephropathy (estimated glomerular filtration rate (egfr) \<60 ml/min/1.73 m2 (based on serum creatinine) and/or albuminuria * taking any kind of medicine on a regular basis * intake of antibiotics two months prior to study * active or recent malignant disease * any treatment or condition requiring acute or sub-acute medical or surgical intervention * any condition considered incompatible with participation by the investigators * if the subjects receive any antibiotic treatment while included in the study they will be excluded