Kornimate/medical-research-clean huggingface dataset:
inflammatory mediators associated with infection by respiratory syncytial virus

Conditions: Respiratory Tract Infections; Respiratory Syncytial Virus Infections

Summary: infection with human respiratory syncytial (rs) virus is the most common cause of hospital stay due to pediatric lower respiratory tract infection. an exaggerated immune response contributes to the pathogenesis and small children may have over reactive airways for a long time after an infection. new research has shown that polymorphonuclear leukocytes (pmns) are stimulated by the virus. besides fighting the infection they also cause collateral damage to the host. among other mechanisms pmns stimulates mucus formation that affects breathing. they also secrete enzymes, toxic proteins and free radicals that may cause harm to lung tissue and airways. the current project strives towards identifying and quantifying inflammatory mediators in sputum, urine and blood of children with severe rs-virus infection. the ultimate aim of the project is to, in detail, describe proteins contributing to the pathogenesis of the disease.


Eligibility criteria:
inclusion criteria: * admission to pediatric intensive care unit * clinical need for invasive ventilation * clinical need for intravascular catheterization * clinical need for urine bladder catheterization * patients with verified or suspected rs-virus-infection or no respiratory tract infection (control group) exclusion criteria: • chronic inflammatory lung disease
efficacy of education programs in patients with chronic airway diseases

Conditions: COPD; Asthma

Summary: the objective of this study is to determine whether the systematic education on air way disease and inhalers in outpatient settings contributes to improve the quality of life. education has been known to be effective for management of chronic airway disease. however, the real benefits remain unclear. an organized education on the chronic airway disease is directed by primary care physicians, and the investigators evaluate the effectiveness of the education.

the present study is a prospective and interventional study comparing the outcomes of education program for one month. a one month education program is composed of three visits (every two weeks follow-up ) during which subjects were taught about their diseases, action plans in acute exacerbation, and inhaler technique. to evaluate the effectiveness of systematic education, questionnaires evaluating quality of life and satisfaction of education will be examined after each visit. asthma control test (act) in asthma, chronic obstructive pulmonary disease (copd) assessment test (cat) in copd subjects were compared before and after education as an index of quality of life. educational effects were also measured, associated with improvement of their knowledge for chronic airway disease itself, proper use of inhaler technique, and satisfaction of subjects after education.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed as asthma or copd 2. patients of over 20 years old 3. patients who agree with voluntary informed consent 4. patients who were prescribed inhaler medication as treatment option exclusion criteria: 1. patients who have comorbid disorders which can influence on the study result (e.g. severe cardiac or kidney disease, cancer, transplantation, bronchiectasis, tuberculous destroyed lung) 2. pregnant women 3. patients who refused to participate in the study
comparison of cosmetic outcomes of lacerations repaired using absorbable versus non-absorbable sutures

Conditions: Lacerations; Wounds; Injuries

Summary: the primary objective of this prospective, randomized study is to compare cosmetic outcomes between absorbable and non-absorbable sutures in truncal and extremity lacerations in the pediatric and adult population. secondary outcome measures include wound complications such as infection and wound dehiscence at the initial visit; and parental satisfaction and keloid formation after three months post repair.

even though there some studies showing good outcomes using absorbable sutures in skin closure in clean surgical wounds, ed based studies still need to be conducted to convince ed physicians that the use of absorbable sutures to close the skin in traumatic lacerations are just as acceptable as traditional non-absorbable sutures. use of absorbable sutures confers several advantages over non-absorbable sutures. for one, patients do not need an additional physician visit either in the office, or more often that not, in the emergency department. these visits add to ed overcrowding, prolonged length of ed stay and are often not reimbursed if seen in the emergency department. moreover, adult patients need to miss work or school and children often have to miss school or daycare to have these sutures removed. the potential to avert another traumatic experience from suture removal in children who had been restrained for suture placement is another advantage of using absorbable sutures over non-absorbable sutures.

Eligibility criteria:
inclusion criteria: 1. isolated injury 2. non-contaminated or minimally contaminated wounds 3. linear laceration 1-5 cms 4. topical adhesives not indicated exclusion criteria: 1. trunk and extremity lacerations less than 1 cm or greater than 5 cm. 2. moderately contaminated wounds or dirty wounds 3. wounds with visible foreign bodies 4. wounds more than 8 hours old 5. wounds that can be repaired using topical adhesives 6. complex wounds needing surgical referral 7. wounds caused by mammalian bites 8. wounds in patients with immune deficiency, pregnancy, diabetes, suspected bleeding disorder or renal dysfunction 9. wounds in patients who are currently taking steroids 10. wounds in areas of tension such as the joint or crease 11. patients with allergic reaction to the topical anesthetic 12. irregular wounds

Keywords: absorbable sutures non-absorbable sutures wound management
impact of alpha lipoic acid efficacy in burning mouth syndrome

Conditions: Burning Mouth Syndrome

Summary: a double-blind placebo-controlled trial is conducted in order to evaluate the efficacy of alpha lipoic acid (ala) and determine the statistical significance of the outcome variables. burning mouth syndrome (bms) is defined as an oral burning sensation in the absence of clinical signs which could justify the syndrome. recent studies suggest the existence of neurological factors as a possible cause of the disease.

a double-blind placebo-controlled trial is conducted in order to evaluate the efficacy of alpha lipoic acid (ala) and determine the statistical significance of the outcome variables. 60 patients with bms, in two groups: case group with 600 mg/day and placebo as control group; with a follow-up of 2 months.

Eligibility criteria:
inclusion criteria: * clinically diagnosed with bms who reported a history of continuous oral burning pain for more than 4 months with no clinical signs that could justify the syndrome exclusion criteria: * clinically diagnosed with bms who reported a history of continuous oral burning pain for more than 4 months with no clinical signs that could justify the syndrome
sonography-guided steroid injection for carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome(CTS)

Summary: purpose: to compare the outcome between sonography-guided steroid injection and direct steroid injection on carpal tunnel syndrome(cts).

material and methods: we have enrolled 26 ideopathic carpal tunnel syndrome patients (minimal to moderate according to padua's classification).thirteen patients were allocated in sonography approach group( sonography-guided local wrist injection, sag) and the 13 patients were placed in direct approach group(direct local injection without using sonography, dag). one , 3 and 6 months later after injection, we performed the outcome measures, including boston symptom and functional scale, quickdash, nerve conduction study and sonography. if the patients receive the second injections, we will follow their treatment outcome by phone regularly at 1,3 and 6 months after first injection. if the patients were referred to surgery, the failures of local injection were considered and we will stop follow up them. after performing all assessment, we will compare the outcomes between the two groups.

Eligibility criteria:
inclusion criteria: * with \>2 following symptoms : 1. disrupt sleep result in nocturnal paresthesia. 2. symptoms release by shaking hand. 3. pain and paresthesia during grasping. 4. any sensory symptom on first, 2th, 3th and partial 4th fingers. * symptoms \>1month. * padua's classification : minimal, mild, moderate) * meet one of three diagnosis criteria of carpal tunnel syndrome. exclusion criteria: * any history can cause periphery nerve disease. * affected side had fracture or paralysis. * had accepted operation for carpal tunnel syndrome before. * pregnant * wrist or hand sprain, ulnar nerve disease cervical nerve root disease, multiple neuropathy or nerve anastomosis. * padua's classification: severe, extreme. * ultrasonography show space occupying. * patient taking anticoagulants. * severe systemic disease. * wrist's skin or wrist joint has infection. * can't complete the 6 months' follow up. * allergy to steroid. * has cognition disorder.

Keywords: carpal tunnel syndrome local steroid injection sonography sonography-guided
does early weight loss following laparoscopic sleeve gastrectomy affect long-term outcomes

Conditions: Hypertension; Diabetes Mellitus, Type 2; Gastrostomy; Morbid Obesity; Weight Loss

Summary: a study to explore the relationship between early weight loss in the 4 weeks following laparoscopic sleeve gastrectomy and outcomes, in terms of weight loss and comorbidity improvement, 7 years following the surgery.

patients who underwent laparoscopic sleeve gastrectomy in the 6 month period between 01/04/2012 and 01/10/2019 were identified. for those meeting the inclusion criteria, demographic and medical data was extracted from hospital notes. this included initial bmi and the presence of, or treatment for, diabetes or hypertension. using the contact details available in the medical records, a scripted telephone interview was performed. the current weight of the patient as well as a current medical and drug history were elicited. this data was compared with data attained during initial patient interaction with the service. early weight loss, defined as weight lost in the 4 weeks following surgery, was subsequently correlated with outcomes in terms of weight loss and improvement/resolution of either hypertension or diabetes at a 7 year follow up interval.

Eligibility criteria:
inclusion criteria: * lsg performed must have been the first surgical procedure performed for that the patient had undergone to treat their obesity * have not undergone any further bariatric surgical procedures since the index operation * still be alive at the time of the study * have correct be contactable with the contact details present available in the electronic database exclusion criteria: * missing data * uncontactable * unwilling to participate

Keywords: sleeve gastrectomy morbid obesity predicting outcomes early weight loss hypertension diabetes mellitus
outcome of radiation therapy in urinary bladder squampus cell carcinoma

Conditions: Urinary Bladder Squamous Cell Carcinoma

Summary: detection of distribution of clinico-pathological features of squamous cell carcinoma of urinary bladder and their relation to treatment outcome.


Eligibility criteria:
inclusion criteria: 1. age 18-70 . 2. histologically proved urinary bladder squamous cell carcinoma. 3. non-metastatic disease. 4. all patients who underwent radical treatment or bladder preserving approach. 5. patient with isolated urinary bladder carcinoma (no other or previous primary). exclusion criteria: 1. age \ 70. 2. patient not documented having bladder squamous cell carcinoma by biopsy (cystoscopic or operative). 3. metastatic disease. 4. patient with synchronous or metachronous double primary
study of alpha-2 adrenergic receptor dysfunction in regional lipoatrophy

Conditions: Lipodystrophy

Summary: objectives: i. determine the response in plasma norepinephrine concentration and plasma glycerol to the agonist (clonidine) and the antagonist (yohimbine) of the alpha-2 adrenergic receptor in 6 patients with regional lipoatrophy and in 6 controls. ii. determine the full sequence of the alpha-2 adrenergic receptor structural gene in genomic dna from peripheral blood leukocytes.

protocol outline: antihypertensives are held, beginning 3 days before the first study day. an oral challenge is administered as follows: clonidine on day 1, yohimbine on day 2. the order of administration is reversed in alternate subjects. timed measurements of norepinephrine, glycerol, and free fatty acids follow each challenge. structural gene sequencing is evaluated for each participant.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- clinical diagnosis of regional lipoatrophy control subjects: women aged 18 to 65 weight 90% to 150% of ideal no significant acute or chronic illness --patient characteristics-- negative pregnancy test required of fertile women

Keywords: endocrine disorders rare disease
effect of resistance training variable manipulation in postmenopausal breast cancer survivors.

Conditions: Breast Cancer Survivors; Postmenopause

Summary: this study intends to evaluate the impact of resistance training variable manipulation (intensity and volume) on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.

the treatment for breast cancer (chemotherapy, radiotherapy and hormone therapy) provokes collateral effects,such as muscle mass and strength losses, increase of fat mass, fatigue and disability and reduced quality of life in postmenopausal breast cancer survivors. the resistance training is assumed as a non-pharmacologic interventions in postmenopausal breast cancer survivors. however, it is unclear whether the manipulation of training variables (intensity and volume) maximize the effects of resistance training on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.

Eligibility criteria:
inclusion criteria: * postmenopausal breast cancer survivors; * no supervised or unsupervised exercise at least for six months prior to the study. exclusion criteria: * alcoholics; * no controlled blood pressure and glucose; * presence of myopathies, arthropathies, and neuropathies; * presence of muscle, thromboembolic and gastrointestinal disorders, infection diseases.

Keywords: breast cancer survivors resistance training fatigability body composition functional capacity
trial to reduce sitting time in postmenopausal latina women at increased risk for heart disease

Conditions: Sedentary Lifestyle

Summary: project 2 of the university of california, san diego (ucsd) american heart association (aha) women's health program will assess 3-month changes in sitting time, standing time, physical activity and blood pressure in a randomized control trial (rct). this 2-arm rct will occur in the community with post menopausal latina women (n=250) who spend at least 8 hrs/day sitting and have increased risk for cardiovascular disease through high bmi and other cardiometabolic risk factors. women will be identified through the san ysidro health center and assessed at the south bay latino research center.

project 2 will address the following aims: 1. investigate the 3 month effect of the intervention to impact the primary behavioral outcomes of sitting, standing and stepping time assessed objectively by a thigh worn inclinometer (activpal) in latinas at risk for heart disease. 2. investigate the 3 month effect of the intervention to impact the secondary health outcomes of blood pressure, depressive symptoms, and anthropometrics. 3. explore the psychosocial \& environmental mediators \& moderators of changes in sitting time.

Eligibility criteria:
inclusion criteria for rct (n=250): 1. postmenopausal woman, no menstruation for at least 1 year, 55+ years of age. 2. self-identify as hispanic ethnicity, able to read and write in english or spanish, 3. ambulatory, medically stable, able to give informed consent, and safely complete the protocols. 4. body mass index range of 25.0-45.0kg/m2. 5. sedentary: average \>8 hours sitting/day, as measured by activpal on 4+ days per week 6. phone access (to receive counseling) prisoners will not be used for this study. exclusion criteria applicable only to the rct intervention trial participants include: 1. unable to complete the short physical performance battery. 2. mental states that would preclude complete understanding of the protocol and compliance. 3. active cancer or another serious chronic illness that may be associated with weight change 4. body mass index \ 45.0kg/m2. 5. use of insulin medications. 6. ≤ 8hr average daily sitting time, as measured by activpal. 7. participating in another clinical trial related to study outcomes (as determined by the pi). 8. unable to wear devices

Keywords: sedentary behavior standing sitting inclinometer
study of sunobinop on craving in alcohol use disorder

Conditions: Alcohol Use Disorder

Summary: the purpose of this study is to evaluate the efficacy of sunobinop compared to placebo on alcohol craving in subjects with moderate to severe alcohol use disorder and these subjects are seeking treatment.


Eligibility criteria:
key inclusion criteria include: * male and female age ≥18 years. * diagnosis of moderate or severe alcohol use disorder. * currently seeking treatment for alcohol use disorder. * has 4 or more heavy drinking days (hdd) in each of the 4 weeks prior to baseline visit. key exclusion criteria include: * subjects that meet current dsm-5 criteria for moderate or severe substance use disorder other than alcohol and nicotine. other protocol-specific inclusion and exclusion criteria may apply.

Keywords: alcohol craving moderate to severe alcohol use disorder
the management of work-disability associated with co-morbid pain and depression: a feasibility study

Conditions: Chronic Pain

Summary: the purpose of the present study was to conduct a preliminary evaluation the feasibility and impact of a risk-targeted behavioral activation intervention for work-disabled individuals with co-morbid pain and depression.

the design of the study was a single arm non-randomized trial. the sample consisted of 66 work-disabled individuals with co-morbid pain and depression. the treatment program consisted of a 10-week standardized behavioral activation intervention supplemented by techniques to target two psychosocial risk-factors for delayed recovery, namely, catastrophic thinking and perceptions of injustice.

Eligibility criteria:
inclusion criteria: * 1) work-disability greater than 4 weeks associated with a musculoskeletal injury to the back or neck, 2) a score above clinical threshold on a self-report measure of depression, and 3) between 25 and 55 years of age. exclusion criteria: * 1) clinical evidence of vertebral fracture, disk herniation, infectious disease, or rheumatoid arthritis: 2) evidence of chronic pain pre-dating the current injury: 3) evidence of loss of consciousness at the time of injury: 4) previous musculoskeletal injury sustained within the past 12 months: 5) evidence of any medical condition that might contraindicate participation in physical activity: 6) illiteracy or severe cognitive impairment.
cct for older diabetic adults

Conditions: Diabetes; Older Diabetic Persons Without Dementia

Summary: the current study examines the efficiency of a home-based computerized cognitive training (ct) intervention targeting older adults with diabetes.the primary aim of the study is to evaluate the effects of cct on cognitive and disease management in non-demented older diabetes adults. investigators will also evaluate the effect of the intervention on a range of secondary outcomes, including mood, caregiver burden, self-efficacy, and for a small sub-sample, on brain activity as reflected in changes in task-related blood-flow on fmri.

evidence suggests a link between diabetes-related processes and increased risk of cognitive decline and dementia in older adults. optimal disease self-management may be key in the prevention of cognitive decline among older diabetic patients, but this may be compromised due to sub-clinical cognitive impairment. in the current study, 120 community-dwelling, non-demented participants aged 65 and over, with a diagnosis of type 2 diabetes will be randomly assigned either to an 8-week, home-based individually-tailored cct program with adaptive difficulty level, and regular performance feedback, or to an 8-week, home-based active control (ac) condition, involving training on a generic cct program with fixed difficulty level and without performance feedback. both intervention groups also include a range of theory-informed behavior change techniques (bcts), including self-efficacy management, self-monitoring and goal-setting in order to enhance treatment fidelity, and to maximize treatment compliance and adherence. in both groups, participants train approx. 30 min. per day, 3 times per-week for 8-weeks. participants undergo a comprehensive evaluation of all outcomes at baseline, immediately after the intervention, and at a 6-month follow-up, with 1-week booster training completed 3 months from completion of the intervention.

Eligibility criteria:
inclusion criteria: * age 65 and over * diagnosis of type 2 diabetes * health cover provided by maccabi health services (mhs) * access to a home computer and internet connection * availability of a close relative/informant with regular and frequent contact with the participant (at least 10 hours per week), willing to respond to questionnaires at all time points. * fluency in hebrew or english * living in the tel-aviv metropolitan area and surrounds exclusion criteria: * an existing diagnosis of dementia * prescription of dementia-related medication. * participation in a previous cognitive intervention study in the preceding year. * significant hearing/vision impairment likely to interfere with assessment and/or training * significant psychiatric/neurological or medical issues that may affect cognitive function.
efficacy of patient controlled epidural anesthesia versus continuous epidural analgesia for post-thoracotomy pain

Conditions: Acute Post-thoracotomy Pain

Summary: postoperative thoracotomy pain is normally managed with an epidural catheter and continuous epidural analgesia (cea). however, for some surgical procedures, patient controlled epidural anesthesia (pcea) is more effective but little research has compared the two methods following thoracotomy. the current randomized, prospective clinical investigation did just this. following institutional ethics approval 52 patients scheduled for thoracotomy were recruited for this prospective, randomized, unblinded study. a thoracic epidural catheter was sited preoperatively. postoperatively all patients were titrated on continuous epidural infusions (hydromorphone 10 mcg/ml + bupivacaine 1 mg/ml) until pain scores were stable at ≤3 on a numeric rating scale (nrs). then they were allocated to their preoperatively determined randomization (either remained on continuous epidural infusion or they were switched to receive 2/3 of the stabilized background dose via continuous epidural infusion with the option to self-administer the remaining 1/3rd of the dose via pcea. participants remained on their allocated analgesic regimens for 48 hours postoperatively. the primary outcome was consumption of local anaesthetics/opioids. the secondary outcomes were worst pain and pain while coughing (0-10 nrs).


Eligibility criteria:
inclusion criteria: * 18-75 years of age * american society of anesthesiologist's (asa) physical status i-iii * body mass index (bmi) \< 40 * able to use a pcea device exclusion criteria: * intolerance/hypersensitivity to agents used in the study * contraindication to epidural placement * current alcohol/substance abuse * chronic pain condition requiring chronic analgesic * bmi ≥ 40 or body weight less than 50kg.

Keywords: anesthesia and analgesia epidural anesthesia administration schedules, drug