Kornimate/medical-research-clean huggingface dataset:
integrative medicine approach to the management of asthma in adults

Conditions: Asthma

Summary: the overall aim of this research project is to test the effectiveness of an integrative program, using journaling, yoga breathing instruction, and nutritional manipulation and supplementation, on quality of life and clinical outcomes in adults with asthma. an additional aim is to determine whether an integrative approach to asthma management leads to cost savings when compared to standard clinical care.patients will be randomly assigned to either the intervention condition or a waitlist control condition. for the intervention group, all measures will be obtained at baseline, immediately after the treatment protocol is completed, and then at three month and six month intervals after the completion of the intervention. for the control group, data will be collected at the same times as the intervention group, with one exception: data collected at the completion of the treatment protocol will be replaced with data collection at six weeks post-baseline for the control group. data will be collected using measures of quality of life (asthma quality of life questionnaire and sf-12), pulmonary function and health care utilization and expenditures. participants assigned to the treatment group will begin in groups of ten. the treatment protocol will consist of six 1-2 hour sessions over a six-week period as follows: 1. subjects will attend a two-session class on healthy eating focused on reducing inflammation-promoting foods in the diet. all subjects will also be started on fish oil and vitamin c supplements, as well as on a supplement called kaprex, which is an extract from hops and rosemary with anti-inflammatory action. supplements willl be provided free of charge. subjects will be provided with a take home supply to begin using. 2. subjects will attend two classes at cchh in yoga breathing techniques and will then be provided with a cd for home study and practice 3. subjects will attend two guided journaling sessions at cchh in which subjects will be asked to write for a 30-minute period about the most traumatic or stressful life experience to date.


Eligibility criteria:
inclusion criteria: 1. age 18-80 2. class ii through iv asthma sufferers will be included (mild persistent; moderate persistent; severe persistent). 3. ability to read and write at minimum fifth grade level 4. willing to comply with study instructions and sign an informed consent 5. english-speaking exclusion criteria: 1. pregnancy or lactation 2. concurrent serious or life-threatening illness as determined by clinical judgment 3. psychiatric disorder as determined by clinical judgment. 4. inability to understand or follow the instructions associated with the clinical study as determined by clinical judgment. 5. fish allergy or history of adverse reaction to vitamin c or fish oil as determined by clinical history.
safety and efficacy study of shape gel in alopecia areata

Conditions: Alopecia Areata

Summary: the purpose of this study is to evaluate the efficacy and safety of shape gel applied topically to adult patients with alopecia areata of the scalp.


Eligibility criteria:
inclusion criteria: * diagnosis of scalp alopecia areata and scalp hair loss due to alopecia areata for a minimum of six months and a maximum of two years. * patients taking thyroid medication or hormonal therapy must be on a stable dose for 6 months and maintain such throughout the study. * willingness to maintain same hair style, including shampoo and hair dye, throughout the study period. * willingness to have a small micro dot tattoo placed to allow for photographic analysis of treatment and application of study medication. exclusion criteria: * history of systemic or cutaneous malignancy and/or lymphoproliferative disease, other than patients with: up to 3 basal cell carcinoma; up to three well differentiated cutaneous squamous cell carcinoma; and/or cervical intraepithelial neoplasm (cin), treated successfully with no evidence of disease, and treated for greater than 6 months prior to study entry. * current actinic keratosis on the scalp and/or face * nevi or cutaneous lesions thought suspicious for malignancy. * history of or current gastrointestinal, pulmonary, cardiovascular, genitourinary or hematological disease, cns disorders, infectious disease or coagulation disorders that would preclude participation in and completion of study assessments. * positive for hepatitis b surface antigen, hiv or hepatitis c. * co-existent androgenetic alopecia: in males: norwood-hamilton stage iv, v or vi; in females: ludwig stage ii or iii. * unwillingness to discontinue use of non-breathable wigs, weaves or shaving of scalp throughout course of study.
ultrafiltration on coagulation function in cardiac surgery

Conditions: Cardiac Valve Disease

Summary: to determine the effect of modified ultrafiltration, which is usually employed for reducing free water at the end of cardiopulmonary bypass (cpb), on coagulation profile in patients undergoing cardiac surgery


Eligibility criteria:
inclusion criteria: * patients undergoing elective cardiac surgery with cardiopulmonary bypass (cpb) * maximal clot formation (mcf) in rotem-extem is reduced exclusion criteria: * mcf \> 50.5 mm before applying ultrafiltration * transfusion of packed rbc\> 3 units during cpb * total ultrafiltration volume \< 250 ml * hyperfibrinolysis (lysis% \> 10%) before applying ultrafiltration

Keywords: coagulation ultrafiltration cardiac surgery
a study of the performance of certain prevail implants used in short fixed cases

Conditions: Partial Edentulism; Tooth Disease

Summary: this prospective, randomized study evaluates the performance and crestal bone changes difference between the osseotite certain prevail vs the non-lateralized design of the implant. study (null) hypothesis: the crestal bone changes that take place after placement and loading of the osseotite lateralized implants will be the same as for similar but non-lateralized osseotite certain implants.

this is a prospective, randomized-controlled study where patients with qualifying partial edentulism received a short fixed bridge restoration. each implant site was randomized to receive either the test (osseotite certain prevail) or the control non lateralized version of the osseotite certain implant. all implants were placed in a single-stage manner with temporary provisionalization taking place two months after implant placement. enrollment continued until 10 patients (approximately 30 implants) were treated at each participating study center.

Eligibility criteria:
inclusion criteria: * patients of either sex and any race greater than 18 years of age * patients for whom a decision has already been made to use dental implants for treating an existing dental condition specifically: a partially edentulous short fixed case of less than 4 implants in the maxilla or mandible; no cantilevers are allowed, but one interior crown may be a pontic * patients must be physically able to tolerate conventional surgical and restorative procedures * patients must agree to be evaluated for each study visit, especially the yearly follow-up visit exclusion criteria: * patients with active infection or severe inflammation in the areas intended for the implants * patients with more than 10 cigarette per day smoking habit * patients with uncontrolled diabetes mellitus * patients with metabolic bone disease * patients who have had treatment with therapeutic radiation to the head within the past 12 months * patients in need of allogenic bone grafting at the site of the intended study implant * patients who are pregnant at the screening visit * patients with evidence of severe para-functional habits such as bruxing or clenching * patients with cantilevers and more than one pontic per bridge

Keywords: dental implants osseotite certain prevail lateralized non-lateralized osseotite certain multicenter randomized clinical study partial edentulism single stage early loading crestal bone level short fixed bridge
maternal betaine supplementation during breastfeeding

Conditions: Overweight and Obesity

Summary: developing more efficient and cost-effective prevention strategies to slow down the worldwide epidemic of obesity and chronic metabolic disease has become a public health imperative. our previous results in humans demonstrate that lower breast milk betaine levels were associated with faster infant postnatal growth, a strong and potentially modifiable risk factor of future obesity. betaine is a trimethylated derivative of glycine, which is present in multiple foods and occurs naturally in breast milk. in this study, we will perform a double-blind randomized placebo-controlled pilot clinical study, in which maternal diet will be supplemented with betaine for 3 months during breastfeeding; infant's growth and adiposity will be monitored until 12 months of age, and breast milk composition and gut microbiota analyzed.


Eligibility criteria:
inclusion criteria: * maternal pre-pregnancy bmi between 25 and 40. * willing to exclusively breastfeed for ≥ 3 months * infant gestational age at birth \> 37 weeks * infant birth weight \> -1 standard deviations * absence of infant disease or malformations at birth exclusion criteria: * multiple pregnancy * lactose intolerance * cbs deficiency (inherited disease)
implementation and evaluation of a fear of cancer recurrence screening, referral and management program

Conditions: Fear of Cancer Recurrence; Cancer

Summary: the purpose of this study is to evaluate the process and outcomes of an implementation program designed to implement fear of cancer screening, referral and management into routine cancer care clinics, using a stepped-wedge cluster randomized controlled trial.

this study aims to test if a systematic fear of cancer screening program that employs implementation strategies including training, reflecting, evaluating, facilitating and adapting, increases the proportion of eligible patients screened and referred compared to usual control with no implantation strategies used. this study hypothesize that the implementation program will increase (i) the proportion of eligible patients screened and (ii) the proportion of patients with high fear of cancer referred for psychosocial support. for process evaluation, this study aims to use qualitative methods to assess the patients' and service providers' experience of the implementation program, and identify contextual factors (e.g., potential barriers and facilitators) likely to influence its adoption, implementation, and sustainability.

Eligibility criteria:
inclusion criteria: * all patients diagnosed with non-metastatic breast, gynecological, or colorectal cancer, and who have completed primary and adjuvant treatment within the past two years will be eligible for the proposed screening program. exclusion criteria: * all cancer patients beyond two years post-treatment; and diagnosed with metastatic cancer or non-breast, non-gynecological, and non-colorectal cancer.

Keywords: implementation study screening and referral program
improving cancer pain management through teach-back educational approach for patients and primary caregivers: a pilot study

Conditions: Cancer Pain

Summary: this randomized prospective quantitative pilot study compared teach-back method to standardized educational method in patient and caregiver to improve cancer pain management

even though there are comprehensive guidelines for cancer pain management, pain control among cancer patients and survivors is often suboptimal due to undertreatment. according to recent studies, the addition of educational interventions could improve pain relief in cancer patients. both patients and family caregivers play an important role in delivering cancer pain self-management, especially at home. providing knowledge for cancer pain management with optimal intervention could improve patient and caregiver outcomes. the teach-back method, where patients and family caregivers are asked to repeat the instruction they've received from their health care professionals, can assess patients' understanding, repeat or modify the educational material if comprehension is not demonstrated. this pilot study compared the addition of the teach-back method for cancer patients and their caregivers and its relation to cancer pain management.

Eligibility criteria:
inclusion criteria: * moderate to severe pain (pain scale 4 and above) * ≥18 years old * signed the informed consent * willing to cooperate until the end of studies * the patient is fully conscious and able to communicate well * cared by a family caregiver * family caregiver able to fully function as a caregiver exclusion criteria: * near-death (dying) stage * not willing to cooperate until the end of studies * altered mental status and communication difficulties

Keywords: cancer pain education
cross-cultural adaptation and psychometric validation of the turkish version of atroshi-lyrén 6-item symptoms scale

Conditions: Carpal Tunnel Syndrome

Summary: this study aims to develop turkish version of the atroshi-lyrén 6-item symptoms scale (a-l scale) and to perform validity and reliability evaluations.


Eligibility criteria:
inclusion criteria: * aged between 18-65 years old, * had symptoms of numbness, tingling, weakness and pain in the hands for at least 1 month, * assessed through provocation tests and physical examination to match the median nerve distribution. exclusion criteria: * not willing to participate in the study, * clinical or electrophysiological signs of proximal nerve compression, * diabetes or other metabolic disease, * rheumatoid arthritis or other general inflammatory diseases.

Keywords: carpal tunnel syndrome pain
study of platelets sialylation by flow cytometry for the differential diagnosis of ict

Conditions: Idiopathic Thrombocytopenic Purpura

Summary: idiopathic thrombocytopenic purpura (itp) is the most frequent auto-immune cytopenia. there is no specific biological marker and the diagnosis often results from the exclusion of other differential diagnoses, notably inherited thrombocytopenia. recent studies have reported an original platelet destruction mechanism in itp, by antibody-mediated desialylation of membrane proteins. the detection of platelet sialylation can be readily achieved using flow cytometry. this could provide a new biomarker of itp, useful to ascertain a diagnosis of itp and guide towards proper patient management.


Eligibility criteria:
inclusion criteria: * adult patients (\>18yo) with a diagnosis of itp (primary acute, persisting or chronical) * adult patients (\>18yo) with a diagnosis of non immunological thrombocytopenia (constitutive thrombocytopenia, myelodysplastic syndrome, chemotherapy-induced thrombocytopenia) * adult patients (\>18 yo) without thrombocytopenia * enrolled in a social security system * having provided informed consent exclusion criteria: * minor patients (\<18 yo) * enrolled in another clinical study * having received corticosteroids or polyvalent immunoglobulins in the past 4 * weeks or anti-platelet therapy or nsaid during the past 7 days * having received platelet transfusion in the past fortnight * with proven iron deficiency * with drug-induced immune-allergic thrombocytopenia. * pregnant and breastfeeding women, * guardian patients, will be excluded from this population.

Keywords: constitutive thrombocytopenia central thrombocytopenia platelets sialylation flow cytometry
effect of connective tissue graft position

Conditions: Gingival Recession

Summary: aim: the aim of this study was to compare the root coverage and aesthetic results of caf+ ctg positioned apical to the cej (caf+ctg-acej) with caf+ctg positioned on the cej (caf+ctg-cej) for treating isolated gingival recession defects. methods: thirthy-eight patients with miller class i and ii gingival recessions were enrolled. 19 patients were randomly assigned to the caf+ctg-acej group or caf+ctg-cej group. clinical and aesthetical evaluations were made at 6 months.


Eligibility criteria:
inclusion criteria: * 19 years of age, * periodontally and systemically healthy, * fmps and fmbs \<15%, * presence of miller class i/ii gr defect (≥3 mm in depth) at the buccal aspect of incisors and canines, * presence of identifiable cej (step ≤1 mm at cej level and/or presence of a root irregularity/abrasion with identifiable cej, was accepted), * no previous periodontal surgery. exclusion criteria: * smoking, * contraindications for surgery, * presence of recession defects associated with caries, deep abrasion, restoration or pulpal pathology.

Keywords: connective tissue graft
rehabilitation in multiple sclerosis: influence of exercise on development of insulin resistance, muscle power and aerobic capacity

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to investigate the development of insulin resistance in multiple sclerosis patients + explaining the effects of a combined training programme on insulin resistance, muscle power and aerobic capacity in multiple sclerosis patients


Eligibility criteria:
inclusion criteria: * diagnosed ms according to the mcdonald criteria * expanded disability status scale (edss) between 0.5 and 6 * be able to train 5 times in 2 weeks at the university exclusion criteria: * comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases (like diabetes type 2) * having had an relapse in a period of 3 months prior to the start of the intervention period * having an relapse during the intervention period * pregnancy and other contra indications for physical activity * mental disorders

Keywords: combined training insulin resistance
phase 1 study of zoledronic acid in sickle cell disease

Conditions: Sickle Cell Disease

Summary: the long-term goal of this study is to learn if zoledronic acid can prevent or reduce pain in sickle cell disease. the goal of this study is to learn about the safety of zoledronic acid in persons with sickle cell disease who experience chronic pain requiring medical treatment or use of narcotics.


Eligibility criteria:
inclusion criteria: * 18 years and older * male or female with sickle cell disease * pain related to sickle cell disease patient history of health services utilization for acute scd-related pain patient history of use of narcotic analgesics for pain control within the past 6 months * able to tolerate hydration with 500 ml d51/2 ns prior to zoledronic acid or placebo exclusion criteria: * calculated creatinine clearance less than 60 ml/min * current active dental problems * recent (within 6 weeks) or planned dental or jaw surgery (e.g., extraction,implants) * history of cirrhosis or chronic symptomatic liver disease; acute liver disease * history of aspirin-induced asthma * history of allergy to zoledronic acid or similar chemical-entities * pregnant or nursing * no prior bisphosphonate use * receipt of an investigational drug within 30 days

Keywords: sickle cell disease
a study to assess the long-term safety and efficacy of asp1941 in japanese diabetic patients

Conditions: Type 2 Diabetes Mellitus

Summary: the primary objective of this study is to evaluate the long-term safety of asp1941 in patients with type 2 diabetes mellitus. the second objectives are to compare the efficacy and pharmacokinetics of asp1941 administered before or after food intake.

subject will be randomized into either asp1941 before meal or asp1941 after meal groups. subjects will undergo a screening period before entering the long-term treatment. dosage may be increased during the treatment period if subjects fulfill increasing criteria and the investigators adjudicate that no impact for subjects safety.

Eligibility criteria:
inclusion criteria: * type 2 diabetic patients for at least 12 weeks * hba1c value between 6.5 and 9.5% * body mass index ( bmi )20.0 - 45.0kg/m2 exclusion criteria: * type 1 diabetes mellitus patients * serum creatinine \> upper limit of normal * proteinuria (albumin/creatinine ratio \> 300mg/g) * dysuria and/or urinary tract infection, genital infection * significant renal, hepatic or cardiovascular diseases * severe gastrointestinal diseases * proliferative diabetic retinopathy

Keywords: blood glucose asp1941 food effect diabetes mellitus
on-line treatment for conduct problems

Conditions: Conduct Disorder; Oppositional Defiant Disorder

Summary: the research evaluates the use of online versions of delivering an effective psychological treatment for children clinically referred for serious oppositional, aggressive, and antisocial behavior. the goal is to develop models of delivery that reach families in need that are not being served by in-person treatment. the project has immediate implications for the treatment of children but more generally addresses several issues critical to treatments that are based on internet, telepsychiatry, and related technologies.


Eligibility criteria:
inclusion criteria: * diagnosis of conduct disorder of oppositional defiant disorder (for the child) * residence in the state of ct * access to a computer and high-speed internet access * english fluency (at least one parent) * no history of significant developmental delay (for the child) * parental consent exclusion criteria: * participation in another form of psychotherapy or counseling that is directed toward the reduction of social, emotional, or behavioral problems * evidence of recent suicidality (for the child) * current or lifetime diagnosis of a pervasive developmental disorder * primary diagnoses of a mood or anxiety disorder * acute family crisis * parent or guardian who can participate in treatment shows current psychosis or an uncontrolled medical condition

Keywords: online treatment treatment of conduct problems parent training
the relief study - researching the effectiveness of lumbar interventions for enhancing function

Conditions: Low Back Pain

Summary: low back pain (lbp) is one of the most common reasons for seeking medical care and accounts for over 3.7 million physician visits/year in the u.s. alone. ninety percent of adults will experience low back pain in their lifetime, 50% will experience recurrent lbp, and 10% will develop chronic pain and related disability. while there is growing evidence for the clinical effectiveness of alternative and complementary therapies to treat low back pain, little is known on the physiologic consequences and effects of these treatments. further, additional data is needed to understand how these different treatment techniques effect clinical changes in pain and disability. the lack of empirical data hinders acceptance by the wider scientific and health-care communities, and it also limits the development of rational strategies for using alternative and complementary therapies.


Eligibility criteria:
inclusion criteria: * report history consistent with chronic low back pain * average pain intensity at least mild when assessed with a numerical pain scale * at least mild disability when assessed with a questionnaire * meets criteria for clinical prediction rule exclusion criteria: * a history of certain neurological, cardiorespiratory, and musculoskeletal disorders * have active cancer or be blind * report recent use of certain medications and treatments * report being pregnant, lactating, or that she anticipates becoming pregnant in the next 3-months * have too high body mass or unexplained weight loss * have clinical depression * have pending litigation related to the low back pain or are receiving any type of disability services * current drug or alcohol use that would interfere with adherence to study requirements

Keywords: low back pain manipulation laser therapy osteopathic chiropractic mobilization muscle energy physical therapy muscle spine adjustment rehabilitation