Kornimate/medical-research-clean huggingface dataset:
comparison of electronic cigarettes and tobacco cigarettes on cardiovascular function and oxidative stress

Conditions: Cardiovascular Risk Factor

Summary: background: electronic cigarettes (e-cigarettes) are battery-powered devices heating a liquid (e-liquid) composed of propylene glycol and/or vegetable glycerin, and most commonly, nicotine to form an aerosol (vapor) that is inhaled (i.e. "vaped"). scarce and conflicting data are available regarding the cardiovascular toxicity of e-cigarettes. we wish to determine the acute effects of propylene glycol/vegetable glycerin and nicotine vaporization at high temperature in comparison to tobacco cigarette smoking on several advanced cardiovascular parameters in healthy chronic e-cigarettes users and tobacco smokers. furthermore, a large range of plasma, urine and respiratory oxidative stress markers will be quantified. by this way, we aim to demonstrate that e-cigarettes-induced systemic oxidative stress could be linked to cardiovascular toxicity. to the best of our knowledge, this is the first project that evaluates the effects of e-cigarettes vaping in comparison to tobacco cigarette smoking on the cardiovascular system in relation to vaporization temperature, nicotine delivery and oxidative stress. aims of the study: this study tests the following hypotheses: 1) acute high temperature vaporization of propylene glycol and vegetable glycerin has no deleterious effects on cardiovascular parameters in comparison to tobacco smoking; 2) tobacco smoking rises plasma and urine oxidative stress biomarkers. on the contrary, acute and chronic e-cigarettes vaping don't rise these biomarkers. at a cellular level, plasma of smokers but not vapers increases superoxide anion production.


Eligibility criteria:
inclusion criteria: * healthy subjects exclusion criteria: * any form of cardiovascular disease * any form of pulmonary disease like asthma or copd * any form of systemic or chronic disorder * active allergy within 4 weeks of the study * symptoms of infection or inflammation within 4 weeks of the study * pregnancy

Keywords: electronic cigarette e-cigarette oxidative stress tobacco smoking
tevagastrim for stem cell mobilization sibling donors

Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndrome

Summary: the aim of this study is to evaluate the efficacy of tevagastrim which is a biosimilar version of filgrastim recombinant human g-csf (g-csf) in mobilizing sufficient number of stem cells from normal sibling donors for allogeneic stem cell transplantation.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 70 years. 2. normal sibling donor that is hla matched to a patient with aml or mds that needs and is eligible for allogeneic stem cell transplantation 3. written informed consent. exclusion criteria: 1. inability to tolerate pbpc harvest. 2. peripheral venous access not possible. 3. positive pregnancy test for female donors. 4. positive serology for hepatitis c and/or hbsag, unless negative for antigen pcr. 5. psychiatric, addictive, or any disorder which compromises ability to give truly informed consent for participation in this study. 6. treatment with other investigational drugs. 7. known sensitivity to cho derived products. 8. hiv positive. 9. history of malignant disease or current malignancy.

Keywords: acute myeloid leukemia myelodysplastic syndrome stem cell mobilization allogeneic stem cell transplantation
effects of phototherapy associated to exercise-based rehabilitation program in heart failure

Conditions: Heart Failure; Physical Activity

Summary: heart failure affects not only the cardiovascular system with structural abnormalities of the heart, but also the musculoskeletal system, leading to exercise intolerance. objective: to evaluate the effects of a short-term exercise protocol and phototherapy, on the functional capacity and inflammatory markers in patients with heart failure. in addition, the investigators will investigate pulmonary function, peripheral and respiratory muscle strength and quality of life. methods: heart failure patients (left ventricular ejection fraction \< 40%) will be selected from the outpatient clinic of the myocardium of the department of cardiology of unifesp and randomized among two groups: patients who will be submitted to placebo phototherapy and cycle ergometer exercise; and patients who will be submitted to active phototherapy and cycle ergometer exercise. all groups will receive treatment twice a week for four weeks. patients will be instructed to conduct home-based walking program at least twice a week. patients will be evaluated before and after protocols regarding the pulmonary function, peripheral and respiratory muscle strength, functionality, quality of life and evaluation of systemic inflammatory mediators.


Eligibility criteria:
inclusion criteria: * heart failure diagnosis determined by clinical presentation and confirmed on echocardiography by clinicians, with a left ventricular ejection fraction (lvef) \< 40% * new york heart association (nyha) classes ii and iii. exclusion criteria: * chronic lung disease confirmed by pulmonary function testing * unstable angina pectoris and acute coronary syndromes * dialysis * neuromuscular and psychiatric conditions that interfere in exercise
pharmacogenetic trial and long-term follow-up of the prisms trial (prisms-15)

Conditions: Multiple Sclerosis

Summary: this study, prisms-15 is a single visit, exploratory pharmacogenetic trial and long-term follow-up of the prisms (prevention of relapses and disability by interferon beta-1a subcutaneously in multiple sclerosis) trial. the aim of this trial is to provide additional data on the driving factors of ifn beta response and the long-term outcomes of rebif® treatment. this is a phase iv trial involving subjects who previously participated in the prisms trial. to address the trial objectives, a single visit will be performed, at least 3 months after the onset of the last relapse.


Eligibility criteria:
inclusion criteria: * was randomized in the prisms study * is willing and able to comply with the protocol * written informed consent given before any trial-related activities are carried out exclusion criteria: * is unwilling or unable to participate in the study

Keywords: biomarkers genetic markers
effectiveness of an online prevention program in reducing the risk of std infection in young adults

Conditions: HIV Infections; Sexually Transmitted Diseases

Summary: this study will evaluate the effectiveness of a tailored interactive online risk reduction program versus a standard online risk reduction program in reducing the risk of sexually transmitted diseases (std) infection in young adults.

adolescents and young adults are at the greatest risk for acquiring an std. approximately 3 million people between the ages of 18 and 24 become infected each year. education about the risks and consequences of unprotected sex is a powerful tool that can be used to prevent or reduce the risk of infection. the program in this study will deliver messages to educate participants about condom use and the risk of std infection. this study will evaluate the effectiveness of a tailored interactive online risk reduction program versus a standard online risk reduction program in reducing the risk of std infection in young adults. participants in this 1-year open-label study will be recruited exclusively via the internet. participants will be randomly assigned to receive internet-based messages from either the youthnet program or the control program. messages from the youthnet program will be interactive and tailored specifically to human immunodeficiency virus/sexually transmitted diseases (hiv/std) risk reduction. the control program will deliver standard std/hiv prevention messages. participants will be assessed at baseline and a follow-up session 4 months after enrollment. frequency of condom use and attitudes toward condom use will be assessed using behavioral scales.

Eligibility criteria:
inclusion criteria: * has access to the internet * has an e-mail address exclusion criteria: * colorado resident

Keywords: hiv prevention internet intervention stds
endoscopic surveillance on a high-risk population for gastric cancer in latin america: the echos cohort study.

Conditions: Gastric Cancer; Dysplasia Stomach; Atrophic Gastritis; Helicobacter Pylori Infection

Summary: the goal of this observational study is to evaluate the risk factors associated with incident hgd/ga in patients with cag with or without im who are enrolled in endoscopic surveillance, as well as to compare ga incidence according to the olga and olgim scales in patients 18 years or older. . the main questions it aims to answer are: * what risk factors are associated with incident hgd/ga in patients with cag with or without im? * what is the comparative hgd/ga incidence according to the olga and olgim scales?

the endoscopic cohort and histological olga staging (echos) study is a retrospective longitudinal cohort developed in the pontificia universidad católica de chile health care system, an open health care system with 3 endoscopic units in santiago, chile. patients 18 years or older were eligible for the study if they had at least one non-urgent outpatient egd with gastric biopsies collected following the ussbp between june 2015 and june 2021. the baseline egd was defined as the earliest examination conducted between this time frame that met inclusion criteria. participants were included in the cohort if they underwent a subsequent "surveillance" egd. in order for the subsequent egd to qualify as surveillance, it needed to occur at least 6 months after the baseline egd and include gastric biopsies collected according to the ussbp; one exception to the ussbp requirement was if hgd or ga was detected on the surveillance (i.e. non-baseline) egd. patients with prior history of hgd or any type of gastric malignancy, gastrectomy or non-gastric active malignancy were excluded. also, patients with hgd or ga on the baseline egd were excluded. patients with indefinite (ind) or low-grade dysplasia (lgd) on the baseline egd were considered for the cohort.

Eligibility criteria:
inclusion criteria: * at least one non-urgent outpatient esophagogastroduodenoscopy (egd) with gastric biopsies collected following the updated sydney system biopsy protocol (ussbp) between june 2015 and june 2021. * underwent a subsequent "surveillance" egd. for the subsequent egd to qualify as surveillance, it needed to occur at least six months after the baseline egd and include gastric biopsies collected according to the ussbp; one exception to the ussbp requirement was if hgd or ga was detected on the surveillance. exclusion criteria: * prior history of hgd or any type of gastric malignancy, gastrectomy, or non-gastric active malignancy. * hgd or ga on the baseline egd was excluded.
comparison of efficacy of two combination regimens for the neisseria gonorrhoeae and chlamydia coinfection

Conditions: Neisseria Gonorrhoeae Infection; Chlamydia Trachomatis Infection

Summary: the frequency of chlamydia trachomatis and neisseria gonorrhoeae coinfection can vary depending on their individual incidence and prevalence rates.single-agent therapy with ceftriaxone is the preferred regimen for treatment of gonococcal infections. if an injectable cephalosporin is not available, cefixime is the only oral cephalosporin that can be used for gonococcal therapy. doxycycline was recommended for presumptive treatment of chlamydia in nonpregnant individuals with gonococcal infection. the study is conducted to evaluate the effectiveness of two regimens in combination with doxycycline with cefixime or ceftriaxone.

gonococcal infections, including urethritis, cervicitis, epididymitis, and proctitis, are a significant cause of morbidity among sexually active men and women. the treatment of these sexually transmitted infections (stis) has evolved over the years, mainly due to the emergence of antibiotic resistance. the frequency of chlamydia trachomatis and neisseria gonorrhoeae coinfection can vary depending on their individual incidence and prevalence rates. ceftriaxone is highly effective against susceptible n. gonorrhoeae. single-agent therapy with ceftriaxone is the preferred regimen for treatment of gonococcal infections. these doses of ceftriaxone are higher than previously recommended due to concerns regarding rising gonococcal minimum inhibitory concentrations (mics) worldwide. if an injectable cephalosporin is not available, cefixime is the only oral cephalosporin that can be used for gonococcal therapy. doxycycline (100 mg orally twice daily for seven days) was recommended for presumptive treatment of chlamydia in nonpregnant individuals with gonococcal infection. the study is conducted to evaluate the effectiveness of two regimens in combination with doxycycline with cefixime or ceftriaxone.

Eligibility criteria:
inclusion criteria: * patient over 18 ages with laboratory-documented uncomplicated chlamydia trachomatis and neisseria gonorrhoeae reinfection at any site exclusion criteria: * pregnancy * breast feeding * hypersensitivity to cephalosporins or penicillins * significant renal failure or hepatic failure

Keywords: neisseria gonorrhoeae chlamydia trachomatis reinfection
hiv care cascade and linkage to antiretroviral therapy among hospitalized adults in lusaka, zambia

Conditions: Hiv

Summary: the population of inpatients is large in zambia; however, because of poor linkages between hospitals and community hiv care, there are few data to analyze their engagement in hiv care before and after hospitalization. the goal of the study is to learn more about zambian adults who are hiv-infected and get hospitalized. the purpose of this study is to gather formative, preliminary data, to be used in future grant applications to improve linkage and engagement in hiv care in zambia.

the main objective of this study is to generate preliminary data on the outcomes of zambian hiv-infected individuals after discharge from university teaching hospital (uth) internal medicine wards which can inform development of a linkage intervention. our central hypothesis is that in sub-saharan african settings like zambia hospitalizations among hiv-infected individuals are driven by suboptimal linkage and initiation of art following hiv diagnosis. specific aims: (a) characterize the distribution of hospitalized 300 hiv-infected adults across the hiv care continuum. (b) identify structural, psychosocial, clinic, and medical factors that predict suboptimal linkage to care and art initiation after 90 days of hospital discharge among hiv-infected zambians.

Eligibility criteria:
inclusion criteria: * 18 years or older * hiv-infected as documented in the uth file * admitted to internal medicine ward at uth exclusion criteria: * unable to provide informed consent * not planning to remain in lusaka province for 3 months after discharge
sensorimotor stimulation, routine physical therapy, balance, cognitive performance mild traumatic brain injury patients

Conditions: Mild Traumatic Brain Injury

Summary: study design: randomized controlled trial settings: physiotherapy department of allied hospital, faisalabad sample size: 27 in each group control group receive: routine physical therapy experimental group receive: routine physical therapy+ sensorimotor stimulation

control group: routine physical therapy time duration: 20 min, rest period: 5 min and treatment will be given 5 days a week and continued for 16 weeks. experimental group: routine physical therapy + sensorimotor stimulation sensorimotor stimulation: sensory stimulation: 1. gustatory stimulation: irrigation of oral cavity, brushing of teeth and tongue, gum massage, 2ml lemon juice on lateral side of tongue, time duration will be 4 min. 2. tactile stimulation: for temperature sensation warm and cold water will applied on different body parts, for touch sensation wet towels and soap will be applied, for pressure sensation body parts will be massaged by lotion, time duration will be 4 min. 3. olfactory stimulation: aromatic stimuli with fragrances to which patient had been familiar e.g. coffee, tea, orange peel and perfume etc. time duration will be 3 min. 4. auditory stimulation: investigator will communicate directly to patients, familiar songs will be utilized, time duration will be 4 min. 5. visual stimulation: colored light, familiar faces, photographs of family members, moving light will be used, time duration will be 4 min. motor stimulation: warm up session for 5-10 min, strengthening exercises for upper and lower limb, for trunk flexors and abdominal curls in supine lying, 10rep 2 sets for 3 times a week, different balance exercise for 6 min 5 times a week.

Eligibility criteria:
inclusion criteria: * patient recruit from outdoor patient department with mild traumatic brain injury having glasgow coma scale score(13-15) * normal intracranial pressure * cardiopulmonary stability exclusion criteria: * preexisting disabilities * suffering from severe medical disease * persistent vegetative state * patients with opium and drug addicted * patients with deafness and delusion disorders

Keywords: concussion
effects of maze activities in down's syndrome

Conditions: Down Syndrome

Summary: down's syndrome is due to the chromosomal disorder in 47 chromosomes instead of 46, socalled as trisomy 21. the syndrome has several clinical symptoms including cardiovascular,neurological, orthopedic, hormonal, cognitive and visual perceptual impairments. these childrenhave developmental delay. children have hypermobility of joints, hypotonicity or ligamentous laxity, light to moderate obesity, due to underdeveloped respiratory and cardiovascular systemandshortstaturewhichleadtodecreaseinfunctionalambulation.due to the low level of physical fitness, theseindividuals shows limitation in performing the functional tasks of daily living. the fundamental motor skill is walking that facilitates the child to interact with the environment and helps indeveloping, social, motor and cognitive skills. due to their delayed milestones and due to the irintellectual disability, environmental exposure is limited which hampers this fundamental skill.hence it is necessary to asses the functional ambulation in these children. this is a randomized controlled trial that will be conducted in rising sun institute of special children. 26 participants will be allocated randomly into 2 groups group a will receive the conventional interventions of down's syndrome but the group b will receive the mobility training with standardized walking obstacle course (swoc). tool used for this research will be a standardized walking obstacle course (swoc) (that is used to measure stability and speed during gait in terms of time, number of steps, number of stumbles and number of steps off the path for each participant) and timed up and go test (valid for the functional mobility assessment of the children with ds). the data will be analyzed by spss version 21

this study will be a randomized control trail used to compare the effects of maze activities on mobility in children with down's syndrome. subjects with down's syndrome meeting the predetermined inclusion and exclusion criteria will be divided into two groups using simple random sampling technique. assessment will be done by using time up and go test and standardized walking obstacle course (swoc). subjects in group a will receive the conventional intervention of gait training and group b will receive the training on standardized walking obstacle course.

Eligibility criteria:
inclusion criteria: * •age 6 to 12 years of downs's syndrome children * ambulatory child who can walk without any assistive device(6) * should follow commands and can perform 30 sec walk test.(6) exclusion criteria: * •any congenital cardiac anomaly * visual and hearing deficits * any surgical intervention for the last 6 months

Keywords: down's syndrome mobility standardized walking obstacle course (swoc).
pressure support ventilation with the anesthetic conserving device

Conditions: Intensive Care Ventilation

Summary: sevoflurane inhalational anesthetic has got pulmonary effects such as bronchodilatation. these effects could be of interest in intensive care patients ventilated in pressure support ventilation mode. the purpose of this study is to evaluate mechanical respiratory effects of sevoflurane administered through a new specific heat and moister exchanger called the anesthetic conserving device (anaconda®) in pressure support ventilation in intensive care patients. in fact, dead space and resistance generated by the device could cancel and even deteriorate the potential positive effects of sevoflurane on ventilation.

pharmacological sedation is often necessary in mechanical ventilated intubated patient. since a little time, sevoflurane can be used in the intensive care unit via a specific heat and moister exchanger called the anesthetic conserving device (anaconda®, sedanamedical ab, uppsala, sweden) placed between the y piece of the ventilatory circuit and the endotracheal tube. sevoflurane is known to have ventilatory interesting effects such as bronchodilatation that can be useful in the treatment of severe asthma. these effects could be of interest in the intensive care ventilated patients. on the other hand, the anaconda® device could have negative influence on ventilatory mechanics caused by the increased dead space and the resistance to air flow. this negative effect with worsening of work of breathing (wob) was demonstrated with classic heat and moister exchanger compared to heated humidifiers in pressure support ventilation (psv). in this way, we would like to study the mechanical effects of the sevoflurane administered with the anaconda® compared to a classic management with a heated humidifier and sedation with intravenous remifentanil in psv consecutive intensive care patients.

Eligibility criteria:
inclusion criteria: * adults icu patients who are no more in acute state, intubated and ventilated in pressure support ventilation with intravenous sedation by remifentanil, with light sedation (rass -1 to -2). exclusion criteria: * respiratory distress.

Keywords: anesthetic conserving device anaconda® sevoflurane remifentanil sedation pressure support ventilation work of breathing intrinsic positive end expiratory pressure ventilatory dead space intensive care weaning of mechanical ventilation ventilated icu patients in psv no more in acute state no respiratory distress sedated by intravenous remifentanil in light sedation as define by a richmond agitation sedation scale (rass) of - 1 to - 2.
trial to evaluate the efficacy of a zinc, selenium, and l-tyrosine supplement in the prevention of thyrotoxicosis in subjects with r25191g/a sepp1 polymorphism

Conditions: Thyrotoxicosis

Summary: this randomized, double-blind, placebo-controlled trial evaluates the efficacy of a zinc, selenium, and l-tyrosine supplement in preventing thyrotoxicosis among adults aged 18-85 with elevated tpoab levels and the r25191g/a sepp1 polymorphism. the study excludes those with thyroid disease, pregnant/breastfeeding women, and individuals allergic to the supplement. key endpoints include changes in thyroid antibodies and hormones over a 6-month period. with an estimated sample size of 150 participants per group, accounting for a 20% dropout rate, the trial seeks to demonstrate the supplement's potential in reducing thyrotoxicosis risk through a genetically-informed approach.


Eligibility criteria:
inclusion criteria: * confirmed presence of one or more specified gene polymorphism r25191g/a sepp1 * tpoab levels \> 300 iu/ml exclusion criteria: * age \ 85 * pregnant or breastfeeding woman * subjects with allergy to any of the supplementation component patients with any established diagnosis of thyroid disease

Keywords: thyrotoxicosis prevention sepp1 polymorphism zinc, selenium, and l-tyrosine supplementation supplementation nutrigenomics thyroid peroxidase antibodies (tpoab)