Kornimate/medical-research-clean huggingface dataset:
botulinum toxin administration on masticatory performance

Conditions: Temporomandibular Disorder; Bruxism

Summary: this study aimed to evaluate the effect of botulinum toxin type a (btx-a) injection on masticatory performance and nutritional status in temporomandibular disorder patients with bruxism caused by both intra-articular and extra-articular pathologies based on research diagnostic criteria for temporomandibular disorders (tmd). the baseline and end masticatory performance, pain intensity, nutrition and anxiety statuses, and anthropometric measurements will be compared.

the main purpose of this study is to determine the effect of btx-a injection on masticatory performance and nutritional status in tmd patients with bruxism. sub-objectives of the study; determination of the effect of btx-a on masticatory performance determination of the effect of btx-a on pain intensity determination of the effect of btx-a on anthropometric measurements determination of the effect of btx-a on nutritional status determination of the effect of btx-a on anxiety status.

Eligibility criteria:
inclusion criteria: * between 18 and 50 years old, * male or female, * able to communicate * able to read and write * volunteer to participate in the study, * at least 3 months of splint treatment and no results * having class 1 molar occlusion and not using removable prostheses * marmara university, faculty of medicine, department of oral and maxillofacial surgery, patients diagnosed with bruxism or myofascial pain in masticatory muscles will be included in the study. exclusion criteria: * sensitivity to botulinum toxin, * have received botox treatment in the last 6 months, * injection site infection * pregnant or lactating women * those with diseases that may cause systemic neuropathy such as diabetes, hypertension, kidney disease, * those who do not want to sign the consent form, * patients with a history of malignancy, radiotherapy or chemotherapy will be excluded from the study.

Keywords: botulinum toxins, type a mastication nutritional status bruxism chewing
correlation between dental caries prevalence in primary teeth and first permanent moilar of children in mixed dentition stage

Conditions: Dental Caries in Children

Summary: to find the clinical relation between caries experience in primary teeth and first permanent molar in mixed dentition stage using def index for primary teeth , dmf index for first permanent molars and to find the clinical relation between caries prevalence in the selected children in relation with other associated factors such as age, sex tooth brushing frequency, dietary habits and mother's attitude toward child's oral health.

the problem for which the study held is lacking of data about relation between prevalence of dental caries in primary teeth and first permanent molar of the same child in mixed dentition stage, incidence of dental caries is influenced by number of risk factors such as age, sex dietary and oral hygiene habits identifying high risk individuals helps development of systemic approaches for preventive oral care programs world wide dental caries is the major public health problem in most high income countries, affecting 60-90%of school children and the vast majority of adults. it also the most prevalent oral disease in several asian and latin american countries although for the moment it appears to be less common and less severe in the greater part of africa, the who report 2003 anticipates that in light of changing living conditions and dietary habits, the incidence of dental caries will increase in many of that continent's low income countries(who,2006)

Eligibility criteria:
inclusion criteria: * egyptian children * children without systemic disease syndromes and disabilities * first permanent molars fully erupted and in occlusion * acceptance of the children's parents to participate in the study exclusion criteria: * any of first permanent molars aren't fully erupted or not in occlusion * children suffering from any systematic disease that affect teeth development

Keywords: risk factors, caries prediction
correlation of vegf-a and fluid balance in septic shock

Conditions: Septic Shock

Summary: vegf is a key molecule in the control of vascular permeability via interactions with the vegf-receptor on the endothelial cell. several authors reported plasma vegf levels are elevated in sepsis shock and associated with increased mortality (1,2). in septic shock, the main elements of treatment are intravenous fluids, appropriate antibiotics and vasopressors. some authors observed positive fluid balance is associated with increased mortality rates in patients (3,4). to the best of our knowledge, no studies have shown a correlation between vegf levels and the fluid balance. the aim of our study was to determine the role of vegf in capillary leakage and the positive fluid balance in septic shock.


Eligibility criteria:
inclusion criteria: * patient above 18 years old * patient with septic shock (presence of an infection, hypotension with mean arterial pressure less than 65mmhg and the need for vasopressor treatment (minimum dose 0,3µ/kg/min) * person informed and signed consent. exclusion criteria: * death predicted within 24 hours * limitation of therapeutic attitudes * treatment with bevacizumab in the past 6 months * pathologies with endothelial dysfunction (scleroderma, clarkson syndrome...) * acute renal failure (kdigo 3) at icu admission defined by : * increase in serum creatinine to \> 354µmol/l or 3 times baseline or * urine output ≤0,3 ml/kg/h for 24h or * anuria for 12h * morbid obesity with a body mass index (bmi) \> 35 kg/m². * limb amputation * morbid obesity with a body mass index (bmi) \> 35 kg/m². * amputation of a limb * pregnant or nursing women * inability to obtain consent from family * person with guardianship or curatorship
silo versus primary closure for gastroschisis

Conditions: Gastroschisis

Summary: the objective of this study is to scientifically evaluate two different closure strategies for gastroschisis to determine if there is a difference in the two approaches.

the hypothesis is that there is no difference between bedside silo placement and operative closure in return of bowel function, ventilator dependence, or length of stay. the primary outcome variable between the two techniques will be length of hospitalization. the likely variables will be length of time to meet discharge criteria, length of hospitalization, time to full feedings, time on mechanical ventilation and total hospital charges.

Eligibility criteria:
inclusion criteria: * infants with gastroschisis exclusion criteria: * born prior to 34 weeks estimated gestational age * another congenital anomaly influencing the respiratory status, gastrointestinal status, or the length of hospitalization and recovery. * inability to get parental permission before treatment.

Keywords: gastroschisis silo primary closure
prevalence and profiles of sports injury in taiwanese adolescent baseball players

Conditions: Sports Injury

Summary: to investigate prevalence and profile of sports injury in taiwanese adolescent baseball players in a longitudinal study.


Eligibility criteria:
inclusion criteria: * taiwanese adolescent baseball players exclusion criteria: * who are not willing to join this study

Keywords: baseball injury
comparison of a patient warming system using a forced-air, non-compressible under-body mattress versus a regular forced-air underbody mattress system during pediatric cardiac catheterization

Conditions: Hypothermia

Summary: the study is a comparison of a patient warming system using a forced-air, non-compressible under-body mattress (möck \& möck, hamburg, germany) versus a regular forced-air underbody mattress system during pediatric cardiac catheterization in 40 patients. the hypothesis is, that the non-compressible mattress provides better warming with less incidence of perioperative hypothermia (core temperature \< 36 °c) and faster warming slope (°c / time). the study is prospective, randomized, controlled and single-blinded. inclusion criteria will be pediatric patients \< 1 year of age without fever or a treatment of therapeutic hypothermia.


Eligibility criteria:
inclusion criteria: * pediatric patient scheduled for cardiac catheterization (diagnostic and/or interventional)\< 1 year old exclusion criteria: * fever or therapeutic hypothermia

Keywords: thermoregulation pediatric anesthesia cardiac catheterization
efficacy of mnd-2119 in participants with hypertriglyceridemia

Conditions: Hypertriglyceridemia

Summary: the purpose of this study is to evaluate the efficacy and safety of mnd-2119 compared to epadel capsules 300 in participants with hypertriglyceridemia.

mnd-2119 is a new formulation of icosapent. this is a phase 3 study to evaluate the efficacy and safety of mnd-2119 compared to epadel capsules 300 in subjects with hypertriglyceridemia. the study period is a total of 22 weeks and is comprised of 8 weeks run-in period, 12 weeks treatment period and 2 weeks follow-up period.

Eligibility criteria:
inclusion criteria: 1. participants diagnosed with hypertriglyceridemia. 2. participants with values of fasting triglyceride level are 150 mg/dl or higher and less than 500 mg/dl. exclusion criteria: 1. participants who have confirmed myocardial infarction and angina pectoris within 6 months. 2. participants who have aortic aneurysm or has received aortic aneurysmectomy within 6 months. 3. participants with, or with a history of, pancreatitis. 4. participants who have a history or complication of a clinically significant hemorrhagic disease within 6 months. 5. participants taking both anti-coagulants and anti-platelets. 6. participants receiving dual antiplatelet therapy. 7. participants taking direct oral anticoagulants.
comparative effectiveness of decision support strategies for joint replacement surgery

Conditions: Hip Osteoarthritis; Knee Osteoarthritis

Summary: this study is a 2x2 factorial randomized trial that will the examine the comparative effectiveness of two patient decision aids for hip and knee osteoarthritis (oa) as well as the impact of a surgeon-focused intervention.

this study is a 2x2 factorial randomized trial that will examine the comparative effectiveness of different decision support strategies for patients making treatment decisions about hip or knee osteoarthritis (oa). eligible patient subjects will be randomly assigned to receive one of two decision aids before their upcoming clinic visit with a participating orthopedic specialist. participating providers are randomly assigned to either usual care or an intervention (a report that includes patients' goals and treatment preferences). patient participants will complete three surveys at different time points: before their orthopedic visit, one week after the clinic visit, and 12 months later. providers will complete a short survey for a subset of patient participants. the study is titled the decide-oa study.

Eligibility criteria:
inclusion criteria: * diagnosis of either hip or knee osteoarthritis * scheduled visit with participating orthopedic surgeon exclusion criteria: * prior partial or total knee or hip joint replacement within last 5 years * hip fracture or asceptic necrosis (avn) in last 12 months * rheumatoid arthritis * psoriatic arthritis * unable to read english or spanish * unable to consent for self due to cognitive or medical issue * hip or knee decision aid provided by partners healthcare clinician within 12 months

Keywords: decision making decision aids decision quality instruments osteoarthritis shared decision making
efficacy and safety of palonosetron hydrochloride in the prevention of nausea and vomiting

Conditions: Neoplasms; Chemotherapy-Induced Nausea and Vomiting

Summary: this purpose of this study is to evaluate the efficacy and safety of single and repeated doses of palonosetron hydrochloride in preventing nausea and vomiting caused by moderate and highly emetogenic chemotherapy in patients.

group i (highly emetogenic chemotherapy): patients that accepted chemotherapy including cisplatin≥50mg/m2, carmustine\>250mg/m2, cyclophosphamide\>1500mg/m2, dacarbazine\>60mg/m2, doxorubicin\>60mg/m2, epirubicin\>90mg/m2, ifo≥10g/m2 or ac program. group ii (moderately emetogenic chemotherapy): patients that accepted chemotherapy including any dose of carboplatin, daunorubicin, oaliplatin, irinotecan, or doxorubicin\ 200mg/m2, ifo\<10g/m2, cisplatin≥50mg/m2. total subjects: 1000, single dose of palonosetron group of 500 patients, repeated doses of palonosetron group of 500 patients. according to the study subjects receiving highly emetogenic chemotherapy or moderately emetogenic chemotherapy, subjects are stratified randomize.

Eligibility criteria:
inclusion criteria: 1. patients candidates to a chemotherapy treatment, with histologically or cytologically confirmed malignant disease; 2. the concrete chemotherapy plan does not limited, group i (highly emetogenic chemotherapy), group ii (moderately emetogenic chemotherapy); 3. male or female aged 18-75 years, ecog≤2, estimates survival time≥3 months; 4. wbc≥3.0×109/l, anc≥1.5×109/l, plt≥80×109/l, total bilirubin≤1.5×uln(normal value upper limit), ast and alt≤2.5×uln(with transferability liver cancer≤5×uln), cr and bun≤1.5×uln, electrolyte and electrocardiogram are normal, conforms to the chemotherapy adaptation; 5. patients have been apart from the previous chemotherapy to finish above 2 weeks (including 2 weeks); 6. patients that voluntarily sign the consent form. exclusion criteria: 1. pregnancy, or patients during breast feeding; 2. patients have accepted any radiotherapy during the experimental period; 3. gastric outlet or intestinal obstruction; 4. patients have serious heart diseases, liver kidney diseases, or metabolism function disorder; 5. patients have epilepsy, or have been used psychotropic drug and calm drug; 6. received any drugs with potential anti-emetic efficacy, or experienced any vomiting, nausea or retching in the 24 hours prior to chemotherapy; 7. patients with transferability brain tumor, have vomiting caused by skull high pressure, or can not speak sickness situation and adverse reactions by self; 8. patients have known hypersensitivity to 5-ht3 antagonists; 9. patients have chemotherapy contraindications; 10. patients are participating, or have participated in other clinical studies of new drugs within 2 weeks.
islet function and clinical analyses of transplant recipients

Conditions: Type One Diabetes Mellitus

Summary: to follow the patterns and natural history of islet transplant recipients (the ones that were involved in the modified edmonton protocol) using oral glucose to check sugar levels as well as insulin and c-peptide over the course of 5 years


Eligibility criteria:
inclusion criteria: * type 1 diabetes with hypoglycemia unawareness that received a islet transplant here at washington university * "control" subjects were matched to the transplant recipients base upon age, height, weight, \& race (and could not have diabetes) exclusion criteria: * well controlled type 1 diabetes * transplant failure * unable to match potential subject to a recipient

Keywords: diabetes
covid-19 and lingering symptoms in primary care patients

Conditions: Covid19; Symptoms and Signs

Summary: the ongoing corona virus disease 2019 (covid-19) is a viral acute respiratory tract infection caused by server acute respiratory syndrom coronavirus typ 2 (sars-cov-2). the signs and symptom of sars-cov-2 infection vary and most people with covid-19 experience illness of mild or moderate severity and recover with symptomatic treatment outside of hospital. studies have found that some people experience lingering/long-lasting symptoms and only a minority of patients were completely free from covid-19 related symptoms after two months. about one third still had up to two residual symptoms and 55% had three or more. as far as we know no study on lingering symptoms has been published in patients after a mild or moderate infection managed in primary care settings. the aim of this study is to explore the course of disease over a one year period and describe lingering symptoms and their impact on well-being and daily activities in adult non-hospitalized patients with previous established covid-19 infection.


Eligibility criteria:
inclusion criteria: * confirmed sars-cov-2 infection, either by polymeras chain reaction (pcr), or by antigen testing (if authorized/recommended/used by national/local governments) * symptoms consistent with mild to moderate covid-19 * maximum of 2 weeks since positive sars-cov-2 test * aged 18 years and older * patient able and willing to comply with monthly phone calls. exclusion criteria: * hospitalisation due to covid-19
follow-up data of patients treated with xigris® in france

Conditions: Sepsis

Summary: the transparency commission wishes that the laboratory lilly france sets up a follow-up study describing the conditions of use of xigris® in france. the purpose of this study is to describe the characteristics of the treated patients, the conditions of drug use, in particular the conditions of treatment initiation and the clinical development of the patients during normal clinical practice, in particular rate and cause of mortality within one month.

the objectives of the study as defined by the specific requirements of transparency commission are as follows: * to describe the characteristics of the patients treated with xigris® * socio-demographic characteristics, * clinical profile * to determine the conditions of use of xigris® * to describe previous treatments, * to observe delay before xigris® initiation, * to describe dose, duration of treatment, * to study the concomitant treatments and the associated treatments * to describe the clinical evolution of the patients * to observe mortality after 1 month * to describe reasons of death

Eligibility criteria:
patients are eligible to be included in the study if they meet the following criteria * patients treated with xigris® during the study period in intensive care units in france * patients with a minimum age of 18 years * patients who are presenting in the normal course of care
comparison of treatments of osteoporotic compression fracture using rigid brace, soft brace, and no brace

Conditions: Compression Fracture

Summary: the treatment outcomes in the treatment without brace would be non-inferior to those in use of rigid or soft brace.

bracing has been considered as a landmark step in conservative management for osteoporotic compression fractures. however, no prospective, randomized, and controlled clinical trials are available to document for the efficacy of wearing of the rigid or soft brace for the management of osteoporotic compression fracture. therefore, the current trial was therefore designed to compare the outcome for improvement of disability and pain in patients with osteoporotic compression fracture using rigid, soft, or no brace.

Eligibility criteria:
inclusion criteria: * the presence of acute back pain caused by a single level vertebral fracture within 3 days of minor trauma such as fall from height, * compression fracture between t 7 and l3 including injuries of only anterior compartment of vertebral body without neurologic deficit. exclusion criteria: * the presence of more than two recent vertebral fractures, * pathologic malignant compression fractures, * neurologic complications, * a history of previous injury or surgery to the fractured level, * inability to complete the questionnaires about pain and disability.

Keywords: osteoporosis, compression fracture, brace
computerized anxiety treatment for suicide

Conditions: Anxiety; Suicide

Summary: the purpose of this study is to test the effectiveness and usability of multiple computer-based treatments for mood and anxiety relevant risk factors. the target of the treatment is related to cognitive stress, which has been shown to be associated with a variety of negative mental health outcomes such as post-traumatic stress disorder, suicidal ideation, and substance use disorders.

cats is a newly developed computerized treatment targeting specific risk factors associated with anxiety symptoms and suicidal thoughts. individuals will be asked to complete four appointments, where they will complete various self-report questionnaires as well as a newly developed computerized treatment targeting risk factors associated with anxiety.

Eligibility criteria:
inclusion criteria: * meet diagnostic criteria for a primary axis 1 anxiety disorder or meet diagnostic criteria for a unipolar mood disorder along with an axis 1 anxiety disorder. * show evidence of current suicidal ideation (bss above 6. * show elevated as indicated by scoring at or above the community sample mean on the asi-cog (above 9. exclusion criteria: * no significant medical illness (e.g. sig cardiovascular disease, epilepsy, stroke). * current or past psychotic-spectrum disorders or uncontrolled bipolar disorder * no current substance dependence * must be an english speaker. * must be 18 years or older. * must have normal or corrected vision * cannot begin treatment/therapy within 1 month of baseline. * cannot begin a new medication within 3 months of baseline.

Keywords: computerized intervention cognitive bias modification anxiety suicide
promoting adherence to anti-hypertensive medications and lifestyle guidelines through mindfulness practice

Conditions: Health Behavior Modification Using Mindfulness

Summary: adherence is a major problem for the approximately one-third of americans over the age of 20 who suffer from hypertension (htn). hypertension can be controlled through medication adherence and lifestyle modifications (diet and exercise). however, nearly 50% of those with htn report poor adherence to their antihypertensive medications, lifestyle changes, or both as primary reasons for failing to control their blood pressure. currently, behavioral interventions are limited to providing education or reminding individuals to take better care of themselves by starting and adhering to proper diet and exercise program. given the lack of adherence reported, education and reminders alone may not be sufficient to promote health behavior change. interventions that appeal to individual's internal drive may be more effective, given that behavior adoption and maintenance are usually associated with intrinsic motivation and volition. mindfulness practice is an intervention that shows promise in changing lifestyle behaviors. the purpose of this study is to investigate the use of ucla's mindful awareness program (uclamap) on promoting self-management behaviors, specifically adherence to medication, diet, and exercise for those individuals with htn. we will randomize 52 individuals with htn who have difficulty with adherence to antihypertensive medications and lifestyle changes to the intervention group or the attention-control group. the intervention includes six sessions of the mindfulness training through ucla's mindful awareness research center (marc).


Eligibility criteria:
inclusion criteria: * over 21 years of age * able to understand and speak english * self-report of having difficulty with a healthy diet and engaging in regular physical activity. exclusion criteria: * on chemotherapy for cancer treatment * current substance abuse disorder (i.e., drugs, alcohol). * current diagnoses of post-traumatic stress disorders, severe anxiety, or severe depression. * on hemodialysis. * pregnant. (pregnant women may develop preeclampsia, which is a pregnancy complication characterized by high blood pressure)

Keywords: hypertension health behavior mindfulness meditation