Kornimate/medical-research-clean huggingface dataset:
atorvastatin efficacy and safety in patients with ulcerative colitis

Conditions: Inflammatory Bowel Diseases

Summary: statins exert numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement, and immunomodulation independent of their basic lipid-lowering properties.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * both males and females will be included * negative pregnancy test and effective contraception. exclusion criteria: * breastfeeding * significant liver and kidney function abnormalities * colorectal cancer patients * patients with severe uc * patients taking rectal or systemic steroids * patients taking immunosuppressives or biological therapies
preventing behavior problems in children with adhd

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: this study will determine the effectiveness of a combination of treatments in preventing behaviors that are typically associated with attention deficit hyperactivity disorder (adhd) in young children.

participants are randomly assigned to either a multi-setting early intervention group or to a community intervention group. the early intervention group receives parent training and assessment-based behavioral and academic intervention for 1 year, followed by either a high or a low intensity maintenance intervention for an additional 18 months. the community intervention group members receive psychotropic medication, special education services, and monthly sessions to obtain information about child development and medical functioning for 2 years. participants are assessed on six occasions over 4 years. parents and teachers assess children's behavior, academic performance, and archival data, including medical and school records.

Eligibility criteria:
inclusion criteria: * attention deficit hyperactivity disorder (adhd) diagnosis * preschool, nursery school, or group daycare enrollment at least 2 days per week * parents who can communicate in english exclusion criteria: * plans to move out of the area in the near future * mental retardation, neurological damage, significant motor or physical impairments, or autism or other pervasive developmental disorder * inattentive adhd or conduct disorder
response of inflammatory markers to circuit weight training in diabetic patients

Conditions: Diabetes Mellitus

Summary: study group included 30 male diabetic patients , they performed circuit weight training exercises for 12 weeks in addition to their medications. however, the control group included 10 patients received medical treatment. interleukin 6 and tumor necrosis factor alpha were measured before and after the study duration for both groups.

the study group included 30 male diabetic patients who participated in circuit weight training (cwt) program as following; 60 minutes training\\day for 3 days per week for a period of 12 weeks. the training session started by a proper warm up for 5-10 min in the form of mild stretching of the muscles of upper limb(pectorals,shoulder girdle muscles) and muscles of lower limb(flexors, extensors, abductors and adductors of the hip and knee) ( to minimize the risk of musculoskeletal injury). then start the active phase of resisted exercises through using free weights ( dumbbels for upper limb and sand bags for lower limb) the frequency and intensity increased gradually as follows; intensity of progress of cwt gradually increased intensity by 2.5% of one repetition maximum every two weeks. moderate resistance used in which of 60-65% of 1rm in the first month then the intensity increased to 70-75% of 1rm in the second month and finally the intensity of exercises increased to 75-80% of 1rm during the third month. the sets of exercises intervened by 1 min rest in between each set of repetitions. at last the session ends by 10 min of cooling down in the form of relaxation exercises. statistical procedures: in this study, the descriptive statistics (the mean, the standard deviation, maximum, minimum, and range) will be calculated for all subjects in the study including il6 and tumor necrosis factor alpha variables. * paired sample t-test will be used to compare the difference between before and after treatment results of il6 and tumor necrosis factor alpha in each group. * paired t test to compare means of variables before and after training.

Eligibility criteria:
inclusion criteria: * the selected subjects are diagnosed clinically and laboratory with diabetes mellitus type 2 by physicians. * all patients have moderate hyperglycemia tested by fasting plasma glucose and a two hours plasma glucose ≥ 200 mg/dl (11.1mmol/l) during an oral glucose tolerance test (ogtt). * the onset of the disease will be more than 10 years. * all patients follow an oral hypoglycemicdrug. exclusion criteria: * hepatic diseases. * cancer patients. * renal failure patients. * orthopedic problems or fractures of extremities. * neurological problems. * severely hypertensive patients.

Keywords: diabetes mellitus. inflammatory markers circuit weight training
second-line treatment of primary autoimmune hemolytic anemia

Conditions: Primary Autoimmune Hemolytic Anemia

Summary: the cyclosporine showed efficacy in many immune cytopenic diseases in the light of numerous case reports and retrospective data. this study compares cyclosporin versus rituximab in steroid-refractory anemia.

auto-immune hemolytic anemia (aiha) is a heterogeneous syndrome in adults. this disease is associated with significant morbidity-mortality. first-line treatment with prolonged corticosteroid is well identified but there is not enough data about cyclosporine treatment in case of resistance or dependence on steroids. the cyclosporine showed efficacy in many immune cytopenic diseases in the light of numerous case reports and retrospective data. this drug is cheap, licensed in immunologic diseases, and does not expose to major infections. so, we compare cyclosporin versus rituximab in steroid-refractory anemia.

Eligibility criteria:
inclusion criteria: * patients aged more than 18 years old from any sex with a diagnosis of primary warm autoimmune hemolytic anemia (aiha) based on the presence of hemolytic anemia and serological evidence of anti-erythrocyte antibodies, detectable by the direct antiglobulin test who have disease progression or failure after treatment with steroid therapy, or who are intolerant to treatment, or who refuse standard treatment. * no evidence of a lymphoproliferative malignancy or other autoimmune-related underlying conditions. exclusion criteria: * any contraindications to the drugs of the study. * any identified secondary cause of the aiha. * pregnant or lactating women.
light sedation or intubated general anesthesia in patients with brain cancer undergoing craniotomy

Conditions: Adult Brain Tumor

Summary: this randomized clinical trial studies light sedation compared with intubated general anesthesia (a loss of feeling and a complete loss of awareness that feels like a very deep sleep) in reducing complications and length of hospital stay in patients with brain cancer undergoing craniotomy. craniotomy is an operation in which a piece of the skull is removed so doctors can remove a brain tumor or abnormal brain tissue. light sedation allows patients to remain awake during their surgery, while intubated general anesthesia puts patients to sleep. surgery complication rates may be reduced if intubated general anesthesia is avoided. additionally, patients not receiving intubated general anesthesia tend to recover more quickly after surgery. it is not yet known whether light sedation is better at reducing complications and length of hospital stay compared to intubated general anesthesia.

primary objectives: i. to compare the overall hospital length of stay (los) in patients undergoing craniotomy with light sedation vs. general anesthesia. secondary objectives: i. to compare resource utilization between the two groups. ii. to assess the frequency of post-operative delirium. iii. to measure patient perceptions. iv. to track patient complications during hospital stay - nausea/vomiting, pain, hematology/lab stability, hemodynamic stability. v. to track re-admission and extended hospital stay rates. vi. to compare cost of both approaches. outline: patients are randomized to 1 of 2 arms. arm i: patients receive light sedation (awake) and undergo craniotomy. arm ii: patients receive intubated general anesthesia and undergo craniotomy. after completion of study, patients are followed up at 1month and 1 year.

Eligibility criteria:
inclusion criteria: * non-pregnant females * elective craniotomy for supratentorial brain tumors * primary brain cancer (presumed gliomas with no radiographic or clinical evidence of metastatic disease to the brain) * first craniotomy * american society of anesthesiologists (asa) i-iii * body mass index (bmi) \< 35 exclusion criteria: * posterior fossa tumor/approach for tumor resection requiring the prone position * traumatic lesions/hematomas * emergency case * systemic disease burden with metastatic tumor to the brain * presence of medical co-morbidities, which, in the opinion of the investigator complicates the surgical procedure or would require additional hospital stay * necessity of awake procedure requiring intraoperative participation of patient due to the presence of the lesion in eloquent brain areas * prisoners * pregnant women

Keywords: supratentorial glioma craniotomy
brain small chain fatty acid metabolism in parkinson disease: tributyrin supplementation

Conditions: Parkinson Disease

Summary: small exploratory open-label pilot study to assess the short-chain fatty acid (scfa) prodrug tributyrin as a potential therapy for persons with parkinson disease

the overarching goal of this small exploratory open-label pilot study is to explore metabolic (glucose metabolism, butyrate) and cognition (moca) before and after open-label treatment with the short-chain fatty acid (scfa) prodrug tributyrin in a small pilot study in pd and normal control older adults. positive findings in this small exploratory pilot trial may support target engagement study of scfa supplementation in normal adults and pd.

Eligibility criteria:
inclusion criteria: * healthy control volunteers over 45 years of age * people with parkinson disease over 45 years of age exclusion criteria: * subjects with contra-indications to mr imaging, including pacemakers or claustrophobia; * evidence of large vessel stroke or mass lesion on mri * regular use of anti-cholinergic, benzodiazepines or neuroleptic drugs * history of significant gi disease * significant metabolic or uncontrolled medical comorbidity * poorly controlled diabetes * pregnancy or breast feeding * dementia requiring informed assent * suicidal ideation

Keywords: short chain fatty acid butyrate tributyrin functional neuroimaging
the clinical study of the poorly differentiated head and neck squamous cell carcinoma

Conditions: Carcinoma, Squamous Cell

Summary: head and neck squamous cell carcinoma (hnscc) is one of the most common head and neck malignant tumors .investigators found that several patients with early tnm stage and poor differentiated hnscc had poor prognosis, yet someone with advanced tnm stage and well differentiated hnscc had good prognosis. hence, investigators suggested that prognosis factors and survival rates probably related to the differentiation of hnscc, and prognosis factor of poorly differentiated hnscc were rare discussed and controversy. investigating the prognostic factors of poorly differentiated hnscc is undoubtedly crucial.

head and neck squamous cell carcinoma (hnscc) is one of the most common head and neck malignant tumors. investigators found that several patients with early tnm stage and poor differentiated hnscc had poor prognosis, yet someone with advanced tnm stage and well differentiated hnscc had good prognosis. hence, investigators suggested that prognosis factors and survival rates probably related to the differentiation of hnscc, and prognosis factor of poorly differentiated hnscc were rare discussed and controversy. investigating the prognostic factors of poorly differentiated hnscc is undoubtedly crucial. about this study ,inclusion criteria were the following parts: the patients of poor differentiated hnscc ; t1-4an0-2m0; pathological examination: poor differentiated squamous cell carcinoma; initial treatment(primary, without surgery, radiotherapy and chemotherapy); range:18-70 years old; kps\>80; hemogram and the function of main organ such as heart, lung, liver and kidney were normal; having the endoscopy, ct and mri before formed into different groups; sign the informed consent file, good compliance. and the exclusion criteria were: uncontrollable epileptic seizure, disorder of central nervous system or unconsciousness cause by psychosis; serious and uncontrollable infection; main organ system failure (including heart ,lung ,liver and kidney); reject training; high and moderate differentiated squamous cell carcinoma

Eligibility criteria:
inclusion criteria: * patients of poor differentiated hnscc ; * patients within the stage of t1-4an0-2m0; * the pathological examination of the patients show poor differentiated squamous cell carcinoma; * patients with initial treatment(primary, without surgery, radiotherapy and chemotherapy); * 18-70 years old; * kps\>80; * hemogram and the function of main organ such as heart, lung, liver and kidney were normal * having the endoscopy, ct and mri signed the informed consent file, good compliance. exclusion criteria: * uncontrollable epileptic seizure, disorder of central nervous system or unconsciousness cause by psychosis; * serious and uncontrollable infection; * main organ system failure (including heart ,lung ,liver and kidney); reject training; * high and moderate differentiated squamous cell carcinoma
observational study of glucose metabolism and how dialysate glucose affects this

Conditions: Glucose Metabolism Disorders

Summary: peritoneal dialysis (pd) is a commonly used treatment for end stage renal failure, and the most commonly used dialysate contains unphysiological amounts of glucose, a high proportion of which is absorbed. recent analysis of the global fluid study, has established that in non-diabetic prevalent patients on pd a random glucose level is dependent on dialysate glucose load and is a predictor of death. by utilising clinical data and additional biosamples collected for the nihr funded pd-craft study, the investigators aim to confirm this finding, define the relationship between dialysate glucose exposure according to prescription regimes and glycaemia, define the most useful biomarker to monitor glycaemia , and establish the role that impaired insulin sensitivity plays in blood glucose levels. furthermore the investigators will explore the hypothesis that insulin resistance is associated with disturbance of the carnitine/acetyl-carnitine equilibrium that might benefit from intra-peritoneal carnitine supplementation. pd-craft is an observational cohort study of 3000 prevalent pd patients collecting detailed clinical data, including glucose exposure and samples of dialysate. and blood which will be stored in the uk biocentre. follow up is for up to 2 years or endpoint (death, technique failure). multivariate regression will be used to establish determinants of the non-fasting blood glucose and other measures of glycaemia, in particular different dialysis regimes, (e.g. modality, dwell lengths, fill volumes, and dialysate type and concentration specifically seeking to identify prescriptions that minimise the systemic effects) combined with measures of insulin resistance. the investigators will establish whether blood glucose predicts survival in an adjusted analysis (\~300 endpoints needed) using cox regression and explore the relationship of other biomarkers to survival.


Eligibility criteria:
inclusion criteria: * on peritoneal dialysis exclusion criteria: * not providing informed consent. * diabetes.

Keywords: glucose dialysate peritoneal dialysis patients non-diabetic
clip ascent and sleeve gastrectomy

Conditions: Sleeve Gastrectomy; Obesity

Summary: this is a single institution study. all patients, one year after sleeve gastrectomy will be included. all will have a ct scan looking for clip ascent. for patients with chronic gastric symptoms such as retrosternal burning, regurgitations, and epigastric pain, a ph-metry will be performed. those symptoms appeared at least 6 months after the surgery. a second consultation is done one year after. the aim of the study is to correlate clip ascent, pyrosis proved by ph-metry and epigastric symptoms after sleeve gastrectomy. the demographic data collection confirms the definition of clip ascent, define its frequency, and look for correlation with the median weight loss.

there is a strong association between gastric reflux and obesity. a severe reflux is a contraindication for a sleeve gastrectomy for some surgeons. however the impact of sleeve gastrectomy on reflux is not clear. a de novo reflux is described for 2 to 18% of patients and many patients have unclear epigastric symptoms. one of the cause could be clip ascent which could justify a second surgery. this is a single institution study. all patients, one year after sleeve gastrectomy will be included. all will have a ct scan looking for clip ascent. for patients with gastric symptoms such as retrosternal burning, regurgitations, and epigastric pain, a ph-metry will be performed. a second consultation is done one year after. the aim of the study is to correlate clip ascent, pyrosis proved by ph-metry and epigastric symptoms after sleeve gastrectomy. the demographic data collection, confirms the definition of clip ascent, define its frequency, and look for correlation with the median weight loss. a medical information note is given to every patient at the first consultation.

Eligibility criteria:
inclusion criteria: * sleeve gastrectomy operated for at least 1 year exclusion criteria: * acute abdominal pain, * epigastric pain occuring after the surgery (no 6 months delay), * pregnant women

Keywords: sleeve gastrectomy clip ascent oesogastric reflux sleeve gastrectomy follow-up
cholesterol lowering level of mk0653a+simvastatin in patients with hypercholesterolemia and atherosclerotic or coronary vascular disease (0653a-806)(completed)

Conditions: Hypercholesterolemia; Atherosclerotic Disease; Coronary Disease

Summary: a 6-week treatment study to compare the reduction in cholesterol of two drugs mk0653a+simvastatin for high cholesterol, in patients with hypercholesterolemia and atherosclerotic or coronary vascular disease.


Eligibility criteria:
- men and women greater than or equal to 18 years of age with elevated cholesterol levels and coronary heart disease (chd), or atherosclerotic vascular disease may be eligible to participate in this study.
characterization and evaluation of diagnostic biomarkers for tuberculosis

Conditions: Active Tuberculosis

Summary: there was no sensitive and specific biomarker for tuberculosis infection, disease progression and predicting the prognosis of treatment. therefore, the investigators aimed to investigate and evaluate the newer biomarker for the diagnosis of tb infection. to investigate the new biomarker for tb infection, the investigators will recruit the participants including active tb patients, healthy household contacts, healthy community control.


Eligibility criteria:
inclusion criteria: * active tb patients : diagnosed with active tb through the microbiologic examination, imaging findings * healthy control : no history of tb treatment, no respiratory symptoms, no evidence of active infectious disease including tb on chest x-ray, no history of close contacts of active pulmonary tb patients exclusion criteria: * pregnant woman * positive result of human immunodeficiency virus examination
study to compare sitagliptin versus sulfonylurea treatment during ramadan fasting in patients with type 2 diabetes (mk-0431-262)

Conditions: Type 2 Diabetes Mellitus

Summary: this is a study comparing the incidence of hypoglycemia while using sitagliptin treatment versus sulfonylurea (su) treatment in participants with type 2 diabetes mellitus (t2dm) who regularly take an su drug, and choose to fast during the month of ramadan. the primary hypothesis is that during the 30 days of ramadan fasting, treatment with sitagliptin (with or without metformin) compared to su treatment (with or without metformin) results in a lower incidence of hypoglycemia in participants with t2dm.

this study and nct01131182 (mk-0431-263) have the same design but are conducted under separate protocols, in different countries, according to local guidelines.

Eligibility criteria:
inclusion criteria: * muslim, with type 2 diabetes mellitus * intends to fast during the month of ramadan * hemoglobin a1c (hba1c) ≤10% at screening * on a stable dose of a su drug (glibenclamide, glimepiride, or gliclazide), for at least three months, with or without metformin therapy at a stable dose exclusion criteria: * type 1 diabetes mellitus * pregnant or breast feeding or with gestational diabetes * hypersensitivity or contraindication to dipeptidyl peptidase-4 (dpp-4) treatment * serum creatinine ≥1.5 mg/dl (males), ≥1.4 mg/dl (females) * history of severe hypoglycemia (defined as a hypoglycemic event requiring the assistance of another individual, and/or resulting in a emergency department admission, physician office visit and/or hospitalization) * any use of insulin (prior to or during ramadan) * use of any class of oral antidiabetic therapy other than an su or metformin * current participation in another interventional study

Keywords: glucose metabolism disorders metabolic diseases peptidase inhibitors