Kornimate/medical-research-clean huggingface dataset:
liposuction as treatment for excessive axillary sweat

Conditions: Hyperhidrosis

Summary: the purpose of this study is to determine if suction-curettage of the axilla is favorable in regard to effect, recovery and cosmetic appearance compared to standard surgical excision of the skin of the axilla in case of excessive sweating.

the surgical standard treatment for isolated excessive axillary sweating is excision of the hair-bearing area of the axilla. this technique is associated with a risk of impaired wound healing, infections, wide scars and a risk of impairment in the movement of the arm (seldom). a new technique suction-curettage, much alike the liposuction technique, in which the dermis is curettage from a sub-dermal approach with a cutting and sucking devise, may be promising in regard to recovery and cosmetic appearance postoperatively, but the effect of the sweat production is not well known. this study compares liposuction vs. standard excision in individuals with isolated excessive isolated axillary sweating randomized to treatment with one of each technique in both axillas.

Eligibility criteria:
inclusion criteria: * adult individuals with primary axillary hyperhidrosis exclusion criteria: * secondary axillary hyperhidrosis * hidrosadenitis axillaris/inguinalis * prior surgery * iontophoresis or botox treatment 12 months prior * known hypersensitivity to local analgetics (lidocaine)

Keywords: hyperhidrosis axillary excision suction-curettage outcome
using three different final irrigants and showing their effects on the success of revascularization

Conditions: Post-operative Pain

Summary: this study will assess different irrigating materials on the success revascularization of necrotic mature teeth associated with prf.

nano-propolis and propolis will be used as final endodontic irrigants and will be compared to saline in revascularization of necrotic mature teeth.

Eligibility criteria:
inclusion criteria: * mature teeth. * teeth with periapical periodontitis. * maxillary anterior teeth * patients should be free from any systemic disease * patients who will agree to the consent and will commit to follow-up period. exclusion criteria: * patients with immature roots. * patients with any systemic disease that may affect normal healing. * patients with swelling. .pregnant females. .patients who could/would not participate in a 1-year follow-up. .patients with fistula. .patients with old age. .teeth with periodontal involvement. .teeth with vertical root fractures. .non-restorable teeth.
drug use-results survey in patients infected with hepatitis c virus genotype 1

Conditions: Chronic Hepatitis C Virus

Summary: the main objective of this study is to evaluate the safety and effectiveness of paritaprevir/ritonavir/ombitasvir used for patients infected with hcv genotype 1 in daily practice in japan.


Eligibility criteria:
inclusion criteria: * hcv genotype 1 patients treated with paritaprevir/ritonavir/ombitasvir in daily practice exclusion criteria: * patients who have been previously treated with paritaprevir/ritonavir/ombitasvir

Keywords: hepatitis c virus (hcv) paritaprevir ombitasvir ritonavir genotype 1
pmcf of rotarex®s & aspirex®s catheters in treating thrombotic occlusion of arteriovenous graft

Conditions: Arteriovenous Graft Thrombosis

Summary: retrospective post-market clinical follow up of rotarex®s \& aspirex®s catheters in treating thrombotic occlusion of arteriovenous graft for dialysis access (artificial bypass)

to evaluate the safety, technical performance, and clinical efficacy of the rotarex®s \& aspirex®s catheters as a stand-alone and adjunctive therapy for the treatment of acute thrombotic occlusion of arteriovenous graft for dialysis access (artificial bypass) in accordance with rotarex®s \& aspirex®s catheters intended use.

Eligibility criteria:
inclusion criteria: 1. female or male subject with a minimum age of 18 years 2. treatment performed between 2013 and 2020 3. occlusion in arteriovenous graft 4. for the rotarex®s group: use of rotarex®s catheter 5. for the aspirex®s group: use of aspirex®s catheter exclusion criteria: 1. subjects not appropriate for this study according to the opinion of the principal investigator
a randomized trial of the ostial versus the extra-ostial ablation strategy for atrial fibrillation

Conditions: Atrial Fibrillation; Arrhythmia

Summary: both segmental, ostial and circumferential, extra-ostial pulmonary vein (pv) isolation have been proven effective in the treatment of atrial fibrillation. in this study patients with symptomatic paroxystic or persistent af were randomised to one of the above mentioned ablation methods. the primary endpoints were recurrent af and recurrence of left atrium-pv conduction.

both segmental, ostial and circumferential, extra-ostial pulmonary vein (pv) isolation have been proven effective in the treatment of atrial fibrillation. in this study with symptomativ paroxystic or persistent af were randomised to one of the above mentioned ablation methods. each patient was allowed a maximum of two ablation procedures. holter monitoring for 14-days periods will be performed at 3 months after ablation. the patiens are seen at out-patient visits at 1, 3, 6, 9, and 12 months after the ablation procedure. primary endpoints were recurrent af and recurrence of left atrium-pv conduction. secondary endpoints were: * safety * resumption of la-pv conduction * alterations in neurohormones * socio-economics aspects(cost effectiveness) * changes in inflammatory markers * quality of life * alterations in signal averaged p wawe signals * evaluation of the predictive value of these variables to predict recurrence of af

Eligibility criteria:
inclusion criteria: * symptomatic paroxysmal or persistent af for more than 6 months, with at least 3 episodes in 3 months and with insufficient effect of at least 2 pharmacological regimens exclusion criteria: * congenital heart disease * age under 18 years * significant valve disease * left atrial size \> 55 mm * prior ablation for af * severe heart failure (lvef \< 20 % and/or nyha class iv)

Keywords: catheter ablation atrial fibrillation
intervention study on medication reconciliation among pharmacists in two tertiary hospitals in nigeria

Conditions: Intervention Study

Summary: this study will assess the current practice of medication reconciliation among pharmacists in the selected institutions with a view to making an intervention to address gaps discovered

background information garnering will be done among the pharmacists in the two selected hospitals to collect data on current practice of medication reconciliation. focus group discussion will be done in the intervention group so as to identify peculiarities of their practice and to provide the best approach to carrying out the intervention. diabetes and hypertensive patients in medical outpatient clinic will be interviewed in order to assess current practice of medication reconciliation. intervention will be channeled towards addressing gaps discovered. university college hospital, ibadan, oyo state will be the intervention group, while university of ilorin teaching hospital, kwara state will be the control group. the effect of the intervention will be measured over time to ensure that medication reconciliation is implemented in the selected institutions.

Eligibility criteria:
inclusion criteria: * participant has diabetes and/or hypertension * registered pharmacists in the selected institutions exclusion criteria: * participants that are neither diabetic nor hypertensive * unregistered pharmacists in the selected institutions

Keywords: intervention study medication reconciliation pharmacists nigeria diabetes hypertension
a randomized triple-blind placebo-controlled study to evaluate the effects of a supplement on lower urinary tract symptoms in men.

Conditions: Lower Urinary Tract Symptoms; Benign Prostatic Hyperplasia; Erectile Dysfunction

Summary: this study aims to evaluate the effects of the prostathrive™ supplement on lower urinary tract symptoms (luts) in men. it is a 90-day virtual, randomized, placebo-controlled trial with 80 male participants aged 40 and above. the primary endpoint is the reduction in luts, while secondary endpoints include changes in sexual function and performance.

this is a virtual two-arm randomized placebo-controlled clinical trial lasting 90 days. participants will take the prostathrive™ supplement or a placebo daily and complete questionnaires at baseline, day 30, day 60, and day 90. the study will assess the efficacy of prostathrive™ on luts such as urinary urgency, nighttime urination frequency, perceived urinary flow, and bladder emptying, as well as secondary outcomes related to sexual function.

Eligibility criteria:
inclusion criteria: * male participants aged 40+ * experience symptoms such as frequent nighttime urination, incomplete bladder emptying, weak urinary stream, and frequent daytime urination * difficulty in getting or maintaining an erection * willing to avoid introducing any new products or medications targeting luts or erectile dysfunction during the study period exclusion criteria: * recent surgeries or invasive treatments * history of prostate or male reproductive cancers * urinary issues caused by neurological conditions * previous surgery on the genitals, prostate, bladder, or urethra * known allergies to product ingredients * diagnosed with chronic health conditions impacting study participation * current substance abuse * participation in other clinical trials * taking medications or supplements targeting luts or erectile dysfunction

Keywords: pumpkin seed extract lycopene stinging nettle beta-sitosterols
incorporation of protein induced by vitamin k absence or antagonist-ii into transplant criteria expands beneficiaries of liver transplantation for hepatocellular carcinoma

Conditions: Cancer of Liver

Summary: this is a multi-center study in china to investigate the role of pivka-ii in hcc recipient selection and prognostic stratification by analyzing the data of 522 recipients with hcc registered in the china liver transplant registry.


Eligibility criteria:
inclusion criteria: * the hcc patients received lt with pre-operative pivka-ii records performed from january 2015 to december 2020, whose clinicopathological data were registered in the cltr. exclusion criteria: * (1) patients who received split lt or simultaneous transplantation, (2) patients who received re-transplantation, (3) patients with macroscopic portal vein tumor thrombosis or other macrovascular invasion, (4) patients with incomplete follow-up or incomplete important parameters records.
a novel method of non-invasive ventilation in children

Conditions: Apnea

Summary: the purpose of this study is to quantify the tidal volume generated by the pressure release immediately following the application of pressure to the chest.

airway management in the pediatric population differs from the adult population because of differences in their respiratory physiology and anatomy. for example the oxygen consumption is about three times higher in children as compared to adults; therefore, if there is a problem ventilating a child there is a higher impact on oxygen delivery and oxygen reserve. current guidelines recommend that in respiratory emergencies where one "cannot ventilate and cannot intubate" that a cricothyroidectomy (insertion of a needle through the cricothyroid membrane in the neck) be performed. this procedure is very invasive and difficult to perform, especially in a small child. since timing and simplicity are essential to successful airway management it is hypothesized that the investigators could utilize the physiological principles behind breathing to ventilate these children using the release of applied pressure to their chest. during, inspiration, the vertical and transverse dimensions of the thorax are increased, generating a negative pressure between the intrapleural space and the chest wall, allowing for air to be drawn into the lungs. as children have a very compliant rib cage one of the theoretical ways to improve lung inflation is to apply external pressure on the chest. the intrathoracic pressure increases above atmospheric pressure and air preferentially flows out of the lungs according to the pressure gradient. when the pressure is released and the chest recoils passively, a negative intrathoracic pressure is generated, which allows for air to flow into the lungs according to the pressure gradient created. if a sufficient tidal volume is generated by the release of pressure from the chest this could potentially become a simple, non-invasive, life-saving technique in children with difficult airways. by adapting the principles described above, it is possible that tidal volume and therefore, gas exchange can take place on release of the pressure applied to the chest.

Eligibility criteria:
inclusion criteria: * all pediatric patients under the age of 18 years old. * all patients requiring a general anesthetic with an endotracheal tube (whether the patient will be intubated with an endotracheal tube will be decided by the anesthesiologist responsible for the case) * asa (american society of anesthesiologists physical status classification) i to iii exclusion criteria: * failure to obtain parental consent or patient assent when appropriate (in general children over 8 years old) * asa (american society of anesthesiologists physical status classification) iv * patients with any cardiac pathology * patients with any respiratory pathology * patients with any form of chest deformity (examples being pectus excavatum, pectus carinatum, scoliosis) * patients who had previous cardiac/thoracic surgery

Keywords: tidal volume pediatric difficult airway ventilation airway management
impact of sasp in the gcf on the outcomes of periodontal regeneration

Conditions: Periodontal Diseases

Summary: objectives: to test the impact of clinical inflammation and molecular expression profile (senescence-associated secretory phenotype; sasp) in the gingival crevicular fluid (gcf) on the outcomes of minimally-invasive periodontal regeneration in intra-bony defects. methods: sites associated with intrabony defects ≥ 3 mm requiring periodontal regeneration through minimally-invasive surgical technique were included. pre-operatively, gcf was sampled for inflammatory biomarker analysis related to sasp \[interleukin (il)-1β, il-6 and il-12; matrix-metalloproteinases (mmp)-8 and -9\]. correlation analyses and logistic regression models were performed to assess the impact of predictors on clinical and radiographic outcomes.


Eligibility criteria:
inclusion criteria comprised: 1) diagnosis of stage iii or iv periodontitis (papapanou et al. 2018b); 2) full-mouth plaque score (fmps) and full-mouth bleeding score (fmbs) of \<15%; 3) completion of steps i-ii of periodontal treatment at least 2 months priorly; 4) tooth with residual ppd ≥ 6 mm, bop+, and a radiographic intrabony component ≥ 3 mm, lacking furcation involvement (aimetti et al. 2023), considered suitable for a minimally invasive procedure (cortellini and tonetti 2007) (fig. 1a). exclusion criteria encompassed: 1) age \< 18 years; 2) current smokers; 3) contraindications to surgery; 4) systemic diseases that could impact periodontal healing; 5) pregnancy and lactation; 6) a history of periodontal surgery at the experimental teeth.
heart rate variability and nocturnal blood oxygen saturation in patients with idiopathic pulmonary fibrosis

Conditions: Idiopathic Pulmonary Fibrosis

Summary: the goal of this observational study is to compare the overnight heart rate variability (hrv) and nocturnal oxygen saturation (spo2) in patients with idiopathic pulmonary fibrosis (ipf). the main questions it aims to answer are: (1). if there are correlations between pulmonary function test and hrv and overnight spo2; (2). if hrv and spo2 can predict the occurrence of acute exacerbation in patients with ipf. participants will be asked to examine pulmonary function test (including lung volumes and six-minute walk test) and wear pulse oxygenation recorder and "largan" ecg holter" ("largan health technology" sleep apnea and sleep quality examination system) during sleep.


Eligibility criteria:
inclusion criteria: * individuals meet the diagnosis of idiopathic pulmonary fibrosis * individuals agree to participate this study and sign the informed consent * individuals have cognitive and behavioral abilities exclusion criteria: * age less than 50 years old * individuals refuse to participate this study and sign the informed consent * individuals of unclear consciousness
a study of rofecoxib versus naproxen in the treatment of chinese patient with rheumatoid arthritis (0966-231)

Conditions: Rheumatoid Arthritis

Summary: a study to compare rofecoxib versus naproxen in the treatment of chinese patients with rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: * chinese males or females at least 18 years of age with rheumatoid arthritis
treatment of heart failure and associated functional mitral valve regurgitation

Conditions: Mitral Valve Regurgitation

Summary: the objective of the study is to evaluate the safety and performance of the arto system in patients with mitral valve regurgitation (mr) associated with congestive heart failure (chf).


Eligibility criteria:
inclusion criteria: 1. is ambulatory, able and willing to comply with the study protocol and has provided written informed consent 2. age ≥ 18 3. trans-septal catheterization is determined to be feasible by the treating physician 4. nyha class ii-iv heart failure of any etiology 5. symptomatic with mr grade ≥ 2+ 6. lvef ≥20% ≤ 50% 7. lvedd \> 50 mm and ≤ 70 mm 8. no anticipated change in patient's cardiac medication regimen anticipated throughout the course of the study. 9. • in the opinion of the investigator and heart surgery team, the patient is not a candidate for surgery, and the use of the arto™ system is technically feasible. exclusion criteria: 1. in the opinion of the investigator, the femoral vein and internal jugular vein cannot accommodate a 16 f catheter or the presence of an inferior vena cava (ivc) filter would interfere with advancement of the catheter or ipsilateral dvt is present 2. significant structural abnormality of the mitral valve (e.g., flail, prolapse, leaflet calcification) 3. significant mitral annular calcification 4. hemodynamic instability (systolic pressure \< 90 mmhg without afterload reduction or cardiogenic shock or the need for inotropic support or intra-aortic balloon pump) 5. prior mitral valve surgery or valvuloplasty or any currently implanted prosthetic valve or vad 6. history of, or active, rheumatic heart disease 7. history of atrial septal defects (asd), whether repaired or not 8. history of previously repaired pfo or pfo associated with clinical symptoms (e.g., cerebral ischemia) within 6 months of the planned investigational procedure 9. in the opinion of the investigator, an atrial septal aneurysm is present that may interfere with transseptal crossing 10. biventricular pacing initiated or anticipated within 6 months of the planned investigational procedure
functional ingredients: effect in gastrointestinal system

Conditions: Overweight; Diabetes; Constipation

Summary: the addition of fructans or unripe banana flour to frozen meals can change the hormonal parameters related to hunger and satiety, improve the bowel movements and increase in colonic bacteria population measured by microbiological determinations (qpcr). the inulin no can change bowel movements and increase in colonic bacteria population measured by microbiological determinations (qpcr)

non-transmissible chronic diseases have been constantly related to the consumption of diets with inadequate nutrient input; at the same time, the ingestion of unavailable carbohydrates have presented an inverse relationship with the risk for these diseases. among these carbohydrates is inulin, a fructan considered as a prebiotic and the unripe banana flour, rich in resistant starch, which may contribute to the intestinal health. this study evaluated the effect of regular intake of frozen soups added functional ingredients (fructans and unripe banana flour) by heath volunteers, about gastrointestinal hormones, satiety and bowel movements.

Eligibility criteria:
inclusion criteria: - good health condition exclusion criteria: * history of renal or gastrointestinal disease * hyperthyroidism * diabetes, nor parents with diabetes * for women: not pregnant, breastfeeding or using hormonal therapy * using any drug that might affect the digestion of food and absorption (antibiotics, laxatives)

Keywords: hunger and satiety hormones gastrointestinal bowel movements
effect of coherent breathing on elderly quality of life

Conditions: Stable Diabetes Mellitus; Geriatrics; Hypertension

Summary: this study will be carried out on sixty elderlies of both gender with ages ranges from 60 to 70 years old. the participants will receive inspiratory muscle trainer and/or coherent breathing exercise three times per week for 12 weeks.


Eligibility criteria:
inclusion criteria: 1. elderly subject of both gender with age ranged from 60 to 70 years old. 2. bmi will be ranged from 25 to 29.9. 3. clinically and medically stable. 4. able to understand the requirements of the study. 5. conscious patient and respond to verbal command. exclusion criteria: 1. neurological conditions (e.g., stroke history, parkinson's disease). 2. presence of an acute illness. 3. metabolically unstable chronic illness. 4. pre-existent untreated metabolic or renal disease. 5. patient undergoes chemotherapy. 6. recent surgery. 7. uncontrolled diabetes or hypertension.