Kornimate/medical-research-clean huggingface dataset:
effect of inspiratory muscle training on the performance of handball athletes

Conditions: Athletic Performance

Summary: this study investigated the effects of an inspiratory muscle training (imt) program on the respiratory muscle strength and resistance and the aerobic physical performance (pp) of handball athletes. nineteen male athletes took part in the study, allocated at random into the experimental group (eg, n=10) and the placebo group (pg, n=9), aged 19±1 and 22±5 years old, respectively. the respiratory muscle strength (rms) was evaluated by measuring the maximum inspiratory and expiratory pressures (mip and mep, respectively), the muscular respiratory resistance was evaluated by maximum voluntary ventilation (mvv) and the aerobic pp by applying the cardiopulmonary exercise test. subsequently the volunteers were submitted to an imt protocol 5 times a week for 12 weeks.

the study was designed to evaluate the effects of a 12-week imt program on the respiratory muscle strength and aerobic physical performance of handball players. nineteen male athletes took part in the study, divided into the experimental group (eg), which took part in the evaluations, maintained their regular sporting activities and carried out the imt (n=10), and the placebo group (pg), which took part in the evaluations, maintained their regular sporting activities and carried out an imt with a load considered to be placebo (n=09), experimental procedures were carried out by trained researchers and a qualified team. the evaluations and imt were carried out during the competitive season, the training frequency being based on the competition program, following the traditional annual model. the athletes were submitted to an initial evaluation composed of measuring the respiratory muscle strength (rms) using a manovacuometer, and an evaluation of the aerobic physical performance carried out using the cardiopulmonary exercise test (cpet). the athletes were reevaluated after 12 weeks for subsequent analysis and comparison with the initial values. all the subjects were previously informed about the experimental procedures, and signed a free and clarified term of consent. the project was approved by the ethics in research committee of the institution with the number 62/13.

Eligibility criteria:
gender: male age limits: minimum age: 18 years maximum age:30 years accepts healthy volunteers? yes eligibility criteria inclusion criteria: * male gender * competition level athlete for at least one year * regularly takes part in the training sessions exclusion criteria: * smoke * shows signs of respiratory and/or cardiovascular diseases * use supplements and/or medication that influences physical performance

Keywords: respiratory muscles athletic performance handball
evaluation of the immediate effect of myofascial release application in patients with chronic low back pain

Conditions: Chronic Low-back Pain

Summary: purpose: to determine the immediate effect of myofascial release application on pain, flexibility and trunk mobility in chronic low back pain (clbp). materials and methods: forty patients with clbp participated in this experimental study. participants were grouped in randomized control. visual analogue scale (vas) was used for pain assessment. sit-reach test for flexibility evaluation and straight leg raising test with goniometric measurement for hamstring flexibility were used. modified schober test was applied to evaluate trunk mobility. comparison of the pre- and post-treatment evaluation data of the individuals in the same group was made using the "wilcoxen sum rank test", one of the non-parametric tests. comparison of pre- and post-treatment evaluation data of both groups was performed using the non-parametric evaluation "mann-whitney u test".

it was aimed to determine the immediate effect of myofascial release application on pain, flexibility and trunk mobility in chronic low back pain (clbp). forty patients with clbp participated in this experimental study. participants were grouped in randomized control. visual analogue scale (vas) was used for pain assessment. sit-reach test for flexibility evaluation and straight leg raising test with goniometric measurement for hamstring flexibility were used. modified schober test was applied to evaluate trunk mobility. comparison of the pre- and post-treatment evaluation data of the individuals in the same group was made using the "wilcoxen sum rank test", one of the non-parametric tests. comparison of pre- and post-treatment evaluation data of both groups was performed using the non-parametric evaluation "mann-whitney u test".

Eligibility criteria:
inclusion criteria: 1. age between 20 and 55 years; 2. low back pain lasting more than 3 months; 3. stable clinical status; 4. no cognitive and mental problems; 5. self-expression ability; 6. volunteering to participate in the study. exclusion criteria: 1. problems of cooperation; 2. malignancy or infection; 3. acute fractures; 4. occlusive edema; 5. osteoporosis; 6. advanced degenerative joint problems; 7. acute rheumatologic conditions; 8. cortisone therapy; 9. use of blood thinners; 10. skin problems.

Keywords: myofascial release chronic low back pain flexibility
investigation evaluating handling of mepitel® one used in acute wounds in home care

Conditions: Acute Wounds

Summary: the primary objective is to evaluate the handling of mepitel® one when used in acute wounds in home care. secondary objective is to evaluate the comfort, conformability, stay-on ability, pain at removal, transparency of dressing and adverse events.

the investigation is designed as an open, non-controlled, proof of concept investigation. subjects with acute wounds at one centre will be included. each subject will be followed once a week for 3 weeks or until healing if that occurs earlier. all dressing changes will be done according to clinical routine and registered in a dressing log. cover dressing will be used when needed according to clinical routine. a total of 10 subjects will be enrolled provided that they fulfil all the inclusion criteria and none of the exclusion criteria and have signed and dated the written informed consent. the subjects will be consecutively allocated to a subject code. at baseline, subject characteristics will be registered together with subject status of health, wound history and wound status, wound characteristics and current treatment of the wound. the following variables will be measured as follows:

Eligibility criteria:
inclusion criteria: 1. acute wounds/burns 2. male or female, 18 years and above, both in- and outpatients. 3. signed informed consent form exclusion criteria: 1. wound size above 21x24.5 cm 2. subject not expected to follow the investigation procedures 3. subjects previously included in this investigation 4. subjects included in other ongoing clinical investigation at present or during the past 30 days
primary care community partnerships to prevent diabetes

Conditions: Hyperglycemia; Obesity; Diabetes Mellitus

Summary: the purpose of this study is to determine if providing free-of-charge access to a group-based lifestyle intervention delivered in partnership with the community is cost-effective for the prevention of type 2 diabetes.

randomized controlled trials have shown that modest lifestyle changes can prevent or delay the onset of diabetes in adults with pre-diabetes. unfortunately, despite the increasing prevalence of pre-diabetes and diabetes in all facets of the population, intervention programs needed to achieve these goals are costly and remain unavailable in most clinical settings. over the past 3 years, we have demonstrated the feasibility of training community instructors to deliver a group-based adaptation of the diabetes prevention program (dpp) lifestyle intervention. in this pilot research, this new delivery model achieves a level of weight reduction that was associated with diabetes prevention and improved cardiometabolic risk factor control in the dpp. this new, large-scale randomized effectiveness trial is designed to evaluate the costs and effectiveness of a partnered approach to identify adults with pre-diabetes in primary care settings, deliver brief advice for diabetes prevention, and provide access to a group-based adaptation of the dpp lifestyle intervention offered by the community. this study will compare costs and outcomes to a standard care, brief clinical counseling approach delivered by registered dietitians.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * body-mass index of 24 kg/m2 or greater * fasting blood glucose 100 - 125 mg/dl, or 2-hour post-challenge capillary glucose 140 - 199 mg/dl exclusion criteria: * cancer requiring treatment in the past 5 years * uncontrolled hypertension: systolic blood pressure \>180 mmhg or diastolic blood pressure \>105 mmhg * heart attack, stroke, or transient ischemic attack in the past 6 months, * chronic obstructive airways disease or asthma requiring home oxygen * other chronic disease or condition, such as advanced arthritis, that could limit ability to become physically active or limit life span to \<5 years * pregnancy * existing diagnosis of diabetes mellitus * fasting capillary blood glucose \> 125 mg/dl * 2-hour post-challenge capillary blood glucose \> 199 mg/dl * history of anti-diabetic medication use (oral agents or insulin) except during gestational diabetes * self-report of a medication known to lead to hyperglycemia (oral steroids, antipsychotics, anti-epileptics) * self-report of disease associated with disordered glucose metabolism: cushing's syndrome; acromegaly; pheochromocytoma; chronic pancreatitis

Keywords: prevention & control hyperglycemia obesity diabetes mellitus cost benefit analysis
effect of dexamethasone on migraine headache

Conditions: Migraine Headache

Summary: dexamethasone is a safe and cheap abortive therapy for migraine headache. the effect of it is never evaluate and not correlate with the effect of popular anti migraine medication such as dihydroergotamine. the investigators proposal is to compare its effect with dihydroergotamine.


Eligibility criteria:
inclusion criteria: 1. migraine attack according to international headache society criteria 2. migraine without aura; at least 5 attack with mean duration of 4 to 72 hours and 2 of following: * unilateral * pulsatile * severe enough to impair daily activity * aggravate with walking and climbing, also 1 of following: * nausea and or vomiting * photophobia and phonophobia, and not contributed to other headache. 3. migraine with aura; at least 2 attacks with 3 of following: * one reversible aura * aura became apparent at least in 4 minutes * aura not lasting more than 60 minutes * headache develops in less than 60 minutes after aura exclusion criteria: 1. hypertension 2. ischemic heart disease 3. basilar migraine with sign and symptoms such as: * diplopia * ataxia * dysarthria * dysphagia * weakness * sensory disorder * drowsiness 4. peripheral vascular disease 5. sepsis 6. age more than 40 and less than 15 year old 7. pregnancy 8. use of triptans and ergots derivatives in past 24 hours

Keywords: migraine dexamethasone dihydroergotamine
disclosing a cystic fibrosis diagnosis to a dating partner

Conditions: Cystic Fibrosis

Summary: this study will examine the experience of disclosing a cystic fibrosis (cf) diagnosis to a dating partner. cf has implications for potential life partners (issues of fertility, decreased life span and an increasing need for medical management with age) that may make disclosure particularly sensitive. an understanding of the disclosure process may provide insight into ways health care practitioners can support their patients during this process. people between 21 and 35 years of age with cf who have been in at least one dating relationship may be eligible for this study. participants are interviewed by telephone about their experiences living with cystic fibrosis and telling dating partners about their diagnosis. the interview includes questions about: * past experiences disclosing their cf diagnosis to a dating partner * what information was disclosed versus what was not disclosed * why certain information was disclosed or not disclosed * positive and negative implications of the disclosure or non-disclosure the interview lasts about 60 minutes and is tape-recorded for later review and analysis.

cystic fibrosis (cf) is an autosomal recessive chronic medical condition. as medical treatment is improving more persons with cf are living into adulthood and are entering into serious dating relationships. a diagnosis of cf has medical implications of concern to potential life partners including infertility, decreased life span and an increasing need for medical management with age. in addition, there is a small but non negligible possibility of future children inheriting the condition. these implications may make this type of disclosure a particularly important event in one's life and may affect one's disclosure decisions. little research has been done on the process of disclosure in this population, and research specifically on disclosure to dating partners is lacking. this study seeks to gain insight into the experience of disclosing a cf diagnosis to a dating partner through semi-structured in-depth phone interviews with approximately 30 persons who have cf and who vary in gender, age, ethnicity, and severity of their condition. the interviews will explore general experiences of disclosure to dating partners, will focus on selective disclosure of certain information to certain recipients, and will explore the implications of the disclosure or non-disclosure experiences. the qualitative interviews will be transcribed and subjected to thematic analysis, which will identify common themes across interviews. an understanding of the disclosure process experienced by persons with cystic fibrosis may provide insight into ways health care practitioners can support their patients during this process.

Eligibility criteria:
* inclusion criteria: self-reported to have been diagnosed with cystic fibrosis. self-reported to be in or have been in at least one dating relationship english speaking. exclusion criteria: younger than 21 years of age; older than 35 years of age.

Keywords: cystic fibrosis disclosure dating partner phone interview
pilot study of the 'thriving with pmds' program

Conditions: Premenstrual Disorder; Premenstrual Dysphoric Disorder

Summary: this study is testing a self-help mental health program that was designed to help people cope with the challenges of living with a premenstrual disorder. individuals with a premenstrual disorder - either premenstrual dysphoric disorder or premenstrual exacerbation of depression - will track their daily symptoms for two menstrual cycles before they complete the program, throughout the two-cycle program, and for an additional two cycles after accessing the program. this will allow the research team to compare their symptoms before and after accessing the program.


Eligibility criteria:
inclusion criteria: * ages 18-42 * either meeting diagnostic criteria for premenstrual dysphoric disorder (to be confirmed by researchers through daily symptom ratings for two menstrual cycles) or major depressive disorder with perimenstrual exacerbation (i.e. at least a 30% increase in 4 symptoms in the perimenstrual phase) exclusion criteria: * taking oral contraceptives * currently in psychotherapy

Keywords: psychotherapy premenstrual disorder premenstrual dysphoric disorder
blood pressure management in the care home population

Conditions: Aging; Hypertension

Summary: the uk care home population is projected to increase significantly over the coming decades. a high proportion of individuals in a care home have multiple long-term conditions and take large amounts of prescribed medication. this means they are routinely excluded from research studies and so there is little evidence on which to base treatment of long-term conditions such as high blood pressure. furthermore, given that 1 in 4 people admitted into a care home die within 1 year, the benefit of treating high blood pressure to reduce the risk of heart attack or stroke must be balanced with the need to optimise quality of life. the aim of this study is to describe the health and social characteristics of the uk care home population with a particular focus on the management of blood pressure in the population. it is hoped that the findings of this study will help inform future research into the management of chronic conditions in care home residents.

the investigators will use the connected bradford dataset to examine uk electronic health records to describe the uk care home population and management of hypertension in this population. the sample will include all adults aged 65 and over who have been admitted into a care home between january 2016 and december 2019. the investigators will extract data at the time of care home admission including age, sex, ethnicity, coded diagnosis of hypertension, indices of frailty and risk of falls as well as comorbidities relevant to cardiovascular risk and falls risk. analysis will include looking at the prevalence of hypertension amongst the care home population, describing treatment patterns (i.e. number and type of prescribed anti-hypertensive medications, frequency of blood pressure monitoring) and the proportion of patients with blood pressure controlled according to national institute of health and care excellence (nice) guidelines. the investigators will also look to establish whether there are any changes in the number and type of prescribed antihypertensive medication before and after admission to a care home (i.e. intensification of pharmacological therapy or deprescribing) and whether this differs amongst different subgroups of populations including patients with terminal illness and stroke diagnosis. the investigators will also estimate frequency of falls in the year following care home admission.

Eligibility criteria:
inclusion criteria: * registered to a gp practice contributing to the connected bradford dataset at the point of admission * a recorded length of stay in a care home of longer than six weeks * recorded social care entry for nursing or residential care in the bradford council social care data. exclusion criteria: * no exclusion criteria applied to keep the sample representative of the real-world care home population.

Keywords: nursing home residential home deprescribing
a study of cognitive health in survivors of prostate cancer

Conditions: Prostate Cancer; Survivorship

Summary: the purpose of this study is to collect information that may help the researchers understand the relationship between prostate cancer survivors' experiences of cancer-related cognitive dysfunction (crcd) and their other conditions (co-morbid factors), including anxiety, depression, and insomnia. the researchers will also find out how additional things may contribute to crcd, including social factors, the characteristics of participants' prostate cancer, and the type of cancer treatment or other medications they received.


Eligibility criteria:
inclusion criteria: * english-speaking * age 18 years or older * history of histologically documented pc of any stage * no evidence of pc disease exclusion criteria: * \<1 month since completion of surgery, radiation, chemotherapy, or adt * diagnosis of alzheimer's disease, vascular dementia, parkinson disease, or other organic brain disorder * score \>10 indicative of dementia on blessed orientation memory concentration

Keywords: cognitive health quality of life 22-223
drug interactions between voriconazole and atazanavir coadministered as atazanavir/ritonavir in healthy participants

Conditions: Human Immunodeficiency Virus Type 1 (HIV-1); HIV Infections

Summary: this study assesses the effects of voriconazole, 200 mg, administered twice daily (bid), on the steady-state pharmacokinetics of atazanavir administered as atazanavir/ritonavir, 300/100 mg once daily (qd), in healthy participants with functional cyp2c19 alleles. the study also reviews the effects of atazanavir/ritonavir, 300/100 mg qd, on the pharmacokinetics of voriconazole, 200 mg, bid in healthy participants with functional cyp2c19 alleles.


Eligibility criteria:
inclusion criteria: * healthy participants as determined by no clinically significant deviation from normal * body mass index (bmi) of 18 to 32 kg/m\^2, inclusive. bmi=weight(kg)/height (m)\^2 * women who are not of childbearing potential (wocbp)(ie, who are postmenopausal or surgically sterile) and men, ages 18 to 45 years, inclusive exclusion criteria: * wocbp * sexually active fertile men not using effective birth control if their partners are wocbp * proven or suspected acute hepatitis (within 12 months prior to the 1st dose) * any significant acute or chronic medical illness * any gastrointestinal surgery that could impact on the absorption of study drug * smoking more than 5 cigarettes per day * history of any hemolytic disorders (including drug-induced hemolysis) * history of acute or chronic pancreatitis * history of hypochlorhydria or achlorhydria * men and women weighing \<40 kg * positive blood screen for hepatitis c antibody, hepatitis b surface antigen, or hiv-1 or hiv-2 antibody * patients with galactose intolerance, lapp lactase deficiency, or glucose-galactose malabsorption
sources of variability in peak expiratory flow

Conditions: Asthma; Lung Diseases, Obstructive; Chronic Obstructive Pulmonary Disease

Summary: to provide information necessary for the development of standards for peak expiratory flow (pef) test performance in populations studies.

background: while pef has routinely been applied in the diagnosis and management of asthma, scientists were finding new applications for pef as both a clinical and epidemiologic tool for following individuals with pulmonary diseases, studying the natural history of chronic obstructive pulmonary disease, and evaluating the impact of environmental exposures on lung function. yet the standardization of the pef measurement lagged behind its application. the little attention paid to the performance characteristics of the pef maneuver contrasted sharply with the efforts to standardize measurement procedures for fev1 and fvc. the american thoracic society devoted a great deal of attention to studying these measures and published guidelines for the standardization of their measurement. these guidelines included detailed protocols for calibrating equipment, administering the tests, determining reproducibility, and interpreting results. the research provided data on the optimal number of trials per test session, the difference between a pef performed during a full forced expiratory effort and that resulting from a short blast, the impact of test supervision on test performance, and the reproducibility of the pef measurement. design narrative: a baseline survey of ventilatory function was performed using spirometry. pef was measured daily with a mini-wright peak flow meter over a period of several weeks in a study of 201 normals (staff, faculty and graduate students at the university of massachusetts lowell). serial pef data were collected on a group of mild asthmatics identified in a local occupational medicine clinic. finally, performance characteristics were examined in serial pef data from two existing occupational cohort studies. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria