Kornimate/medical-research-clean huggingface dataset:
availability study of acth to treat children srns/sdns

Conditions: Proteinuria

Summary: primary nephrotic syndrome(ns) is a common children renal disease.about 20% primary nephrotic syndrome are steroid-dependent and steroid-resistant.low serum cortisol is one of the main relapse reasons.adrenocorticotropic hormone(acth)-induced steroidogenesis improve serum cortisol and also direct melanocortin receptors(mcrs) mediated protective effect on kidney cells. to investigate the efficacy and safety of acth to treat ns, total 42 children steroid resistant or steroid dependent ns is enrolling in this multicenter, prospective case series of prescription based treatment with acth for ns.

primary nephrotic syndrome(ns) is a common children renal disease.about 20% primary nephrotic syndrome are steroid-dependent and steroid-resistant.low serum cortisol is one of the main relapse reasons.adrenocorticotropic hormone(acth) can stimulates the adrenal cortex and its production of corticosteroids.acth also direct melanocortin receptors(mcrs) mediated protective effect on kidney cells. to investigate the efficacy and safety of acth to treat ns, total 42 children steroid resistant or steroid dependent ns is enrolling in this multicenter, prospective case series of prescription based treatment with acth for ns.

Eligibility criteria:
inclusion criteria: 1. age:3-12 years old 2. primary nephrotic syndrome 3. srns or sdns 4. minor lesion or minimal change disease 5. signed informed consent exclusion criteria: 1. second nephrotic syndrome 2. allergic to acth 3. refuse to signed informed consent 4. have had acth treatment 5. serious complication
a future-oriented group training for suicidal patients

Conditions: Suicidal Ideation; Suicide Attempt

Summary: the main goal of this study is to evaluate the effectiveness of a future-oriented group training aimed at reducing suicidality in adults. this will test the effectiveness by studying the effect on suicidal ideation and related outcomes, compared to treatment as usual. participants will also be asked to evaluate the group training. the study is a multicentre randomized controlled trial conducted in out-patient flemish mental healthcare facilities.


Eligibility criteria:
inclusion criteria: * speak dutch * be at least 18 years old * have access to internet * be suitable for group therapy * have mild to severe suicidal thoughts (bss score of minimum 1) exclusion criteria: * conditions expected to severely hinder group participation, comprehension of the training content or adherence
application of antiosteoporosis therapy in osteolysis

Conditions: Limb; Fusion; Complication

Summary: to report the postoperative complications and limb function of patients with osteolysis after surgery for bone tumors of the extremities who received anti-osteoporosis therapy in henan cancer hospital in the next 10 years.

a total of 100 patients with osteolysis after surgery for bone tumors of the four extremities who received anti-osteoporosis treatment in henan cancer hospital in the next 10 years were reported. the basic information, treatment methods, postoperative complications and limb function of these patients were collected.

Eligibility criteria:
inclusion criteria: 1. no age restriction, male or female. 2. a subtype of bone tumor (including benign, malignant, and metastatic cancer) was confirmed in the pathology department of the research institution. 3. received excision of bone tumor in research institution. exclusion criteria: not applicable.
lung recruitment assessment with lung ultrasound in pediatric patient scheduled for laparoscopic surgery

Conditions: Atelectasis

Summary: anesthesia-induced atelectasis is a well-known entity observed in approximately 68-100% of pediatric patients undergoing general anesthesia. the collapse of dependent lung zones starts with anesthesia induction but can persist for hours or even days after surgery. such anesthesia-related atelectasis has a number of negative clinical consequences such as the impairment of arterial blood oxygenation and lung mechanics as well as the predisposition for ventilator-associated lung injury. the adjustment of ventilator settings for preventing the occurrence of atelectasis and for reducing pulmonary complications remains controversial. lung sonography (lus) plays an important role in diagnosing pulmonary diseases in children, including atelectasis of different origins. lus has demonstrated its high sensitivity and specificity for diagnosing anesthesia-induced atelectasis in children.

compare lung aeration between two different mechanical ventilation strategies (protective mechanical ventilation and recruitment maneuvers) in pediatric patients scheduled for abdominal laparoscopic surgery using ultrasound imaging and a four-point-aeration score to assess the lung aeration.

Eligibility criteria:
inclusion criteria: * written informed consent by parents. * patients aged 6 months to 7 years old * scheduled for abdominal laparoscopic surgery * american society of anesthesiologists classification: physical status i-ii exclusion criteria: * acute airway infection * cardiovascular and or pulmonary disease * previous thoracic procedure

Keywords: atelectasis children lung ultrasound lung recruitment
a study of tadalafil (ly450190) in chinese men with erectile dysfunction

Conditions: Erectile Dysfunction

Summary: the purpose of this study is to evaluate the safety and effectiveness of the study drug, taken once daily, known as tadalafil in chinese participants with erectile dysfunction (ed). the study will last about up to 25 months for each participant.


Eligibility criteria:
inclusion criteria: * have a history of erectile dysfunction for at least 3 months. * are sexually active and willing to remain sexually active with the same female partner during the study. * are willing to have 4 or more attempts of sexual intercourse with female partner between screening and first treatment start day. * are willing to stay away from any other medicines that the participants were already taking for erectile dysfunction during this study period. exclusion criteria: * have erectile dysfunction, which is caused by any other primary sexual disorder. * have certain problems with kidneys, liver, heart, blood sugar levels, eyes, or central nervous system (study doctor will discuss with participants). * have a penis deformity or penile implant that in the opinion of the participants' doctor is significant. * have human immunodeficiency virus (hiv) infection. * are using certain kinds of medicines, which are not allowed in this study. * are allergic to tadalafil. * are planning to father a baby or are in a relationship with a pregnant partner. * are participating or discontinued participation in the past 30 days from any another clinical trial, which is not compatible with this trial. * have participated or discontinued from any other tadalafil clinical trial. * have a history of drug, alcohol, or substance abuse within the past 6 months.
eras in patients with perforated peptic ulcer disease who underwent laparoscopic repair

Conditions: Hospital Stay; Hospital Cost

Summary: perforated peptic ulcer (ppu) is a frequent emergency condition worldwide with associated mortality up to 30%. open procedures have in the most part been replaced by laparoscopic techniques. the standard postoperative management of ppud patients is predominantly based on traditional practices. the aim of this randomized controlled clinical trial was to investigate the feasibility of enhanced postoperative recovery pathways in patients who underwent laparoscopic repair for perforated peptic ulcer.

perforated peptic ulcer (ppu) is a frequent emergency condition worldwide with associated mortality up to 30%. open procedures have in the most part been replaced by laparoscopic techniques. the standard postoperative management of ppud patients is predominantly based on traditional practices. randomization will be made at the end of the surgical procedure. patients will be included in groups 1 or2. group 1 is the control group and will receive standard postoperative care, and group 2 is the eras group.the aim of this randomized controlled clinical trial was to investigate the feasibility of eras in patients who underwent laparoscopic repair for perforated peptic ulcer.

Eligibility criteria:
inclusion criteria: 1. perforated ulcer less than 10 mm in size 2. patients received laprascopic repair exclusion criteria: - 1. refusal to join the study or sign the informed consent form 3. age younger than 18 years 3.the presence of any psychiatric or neurologic disease 4. class 3 and 4 surgical patients according to the classification of the american society of anesthesiologists 5. septic shock on admission 6. pregnancy 7. multiple perforated peptic ulcers 8. spontaneously sealed-off perforated ulcers that were diagnosed either preoperatively or during surgery and that did not require surgical repair 9.conversion to open technique 10. perforated ulcers that were not amenable to graham patch repair because of size or technical considerations

Keywords: perforated peptic ulcer enhanced recovery after surgery laparoscopic repair complications
clinical trial to evaluate the chronic efficacy of oc-01 nasal spray on signs of dry eye disease (the mystic study)

Conditions: Dry Eye Disease

Summary: the objective of this study is to evaluate the chronic safety and effectiveness of oc-01 nasal spray as compared to placebo on signs of dry eye disease (ded).

study opp-004 was a phase 2, single-center, randomized, masked (including subjects, investigators, and study site personnel), placebo-controlled study designed to evaluate the safety and efficacy of oc-01 (varenicline) nasal spray in adult subjects with ded. the study planned to randomize approximately 120 subjects at least 22 years of age with a physicians' diagnosis of dry eye disease and meeting all other study eligibility criteria to receive an application of oc-01 or placebo bid for 12 weeks. subjects who terminated early during the application period were asked to complete safety assessments (if the subjects agree) prior to study exit. subjects who were terminated early from the study were not replaced.

Eligibility criteria:
inclusion criteria: * have used and/or desired to us an artificial tear substitute for dry eye symptoms within 6 months prior to visit 1 exclusion criteria: * have had any intraocular surgery (such as cataract surgery), extraocular surgery (such as blepharoplasty) in either eye within three months or refractive surgery (e.g. laser-assisted in-situ keratomileusis, laser epithelial keratomileusis, photorefractive keratectomy or corneal implant) within twelve months of visit 1 * have a history or presence of an ocular disorder or condition in either eye that would, in the opinion of the investigator, likely interfere with the interpretation of the study results or participant safety such as significant corneal or conjunctival scarring; pterygium or nodular pinguecula; current ocular infection, conjunctivitis, or inflammation not associated with dry eye; anterior (epithelial) basement membrane corneal dystrophy or other clinically significant corneal dystrophy or degeneration; ocular herpetic infection; evidence of keratoconus; etc. blepharitis not requiring treatment and mild meibomian gland disease that are typically associated with ded are allowed. * have a systemic condition or disease not stabilized or judged by the investigator to be incompatible with participation in the study or with the lengthier assessments required by the study (e.g., current systemic infection, uncontrolled autoimmune disease, uncontrolled immunodeficiency disease, history of myocardial infarction or heart disease, etc.) * have a known hypersensitivity to any of the procedural agents or study drug components * have any condition or history that, in the opinion of the investigator, may interfere with study compliance, outcome measures, safety parameters, and/or the general medical condition of the subject
safety and tolerability of ceftazidime-avibactam for pediatric patients with suspected or confirmed infections

Conditions: Systemic Infections

Summary: to assess the pharmacokinetics, safety and tolerability of a single dose of caz-avi in children from 3 months of age to \<18 years.

this is a phase i, open-label, single-dose study. the study aims to characterize the pharmacokinetics of caz-avi and assess its safety and tolerability following a single iv dose given to hospitalized pediatric patients receiving systemic antibiotic therapy for suspected or confirmed infection. this study will include 4 cohorts, each consisting of at least 8 evaluable pediatric patients, aged ≥3 months to \<18 years, who are hospitalized with infections.

Eligibility criteria:
inclusion criteria: 1. written informed consent will be obtained from parent(s) or other legally acceptable representative(s), and informed assent from patient (if age appropriate) will be obtained 2. male or female children ages ≥3 months to \<18 years. 3. hospitalized, receiving systemic antibiotic therapy for the treatment of a suspected or confirmed infection, and expected to require hospitalization until after the end of treatment (eot) evaluations are completed. 4. if female and has reached menarche, or has reached tanner stage 3 breast development (even if not having reached menarche), the patient is practicing appropriate birth control or is sexually abstinent. 5. likely to survive the current illness or hospitalization. 6. sufficient intravascular access (peripheral or central) to receive study drug. exclusion criteria: 1. history of hypersensitivity reactions to carbapenems, cephalosporins, penicillin, other β-lactam antibiotics. 2. if female, currently pregnant or breast feeding or has a positive serum β-human chorionic gonadotropin (β-hcg) pregnancy test. 3. receipt of a blood or blood component (e.g., red blood cells, fresh frozen plasma, platelets) transfusion during the 24-hour period before enrolment. 4. bmi outside the range (below the 5th percentile or above the 85th percentile) for height, age, and weight except for children \<2 years of age. 5. babies born prior to 37 weeks gestation (cohort 4 only).

Keywords: ceftazidime, avibactam, anti-infectives
prevention of abdominal incisional hernia after laparoscopic digestive surgery in obese patients (bmi>30kg/m2)

Conditions: Obesity

Summary: the hypothesis of this study is to show that after laparoscopic digestive surgery in obese patients (bmi\>30kg/m2), the wearing of an abdominal support belt is an effective treatment for the incisional hernia and feasible in terms of compliance, quality of life and patient satisfaction

the study will be conducted at the institut mutualiste montsouris, it is planned to include 350 patients in 12 months, the duration of participation of each patient is 24 months. an orthopaedist will see patients in consultation to take their measurements, patients complete a quality of life questionnaire (the sf 36), when they are admitted for surgery. after surgery, patients begin wearing their belts according to the instructions given by the surgeon during hospitalization: * start wearing the belt as soon as possible. * wear it according to its recommendations: all day, every day of the week and for two months. patients should record the number of hours they would have worn their belts in the evinov logbook each day. the studu co will contact patients by phone every two weeks for the 2 months they will be wearing the belt. at the one-month post-operative consultation, the patient will complete a quality of life questionnaire again (the sf 36). two months after surgery, patients receive a final sf 36 questionnaire by mail, with a satisfaction scale to evaluate their overall feeling around the period of wearing the abdominal belt. patients are asked to return these two documents, as well as the evinov logbook. the latest health data collection is the imaging data from the abdominal ct scan at 24 months, which will show the presence or absence of an incisional hernia.

Eligibility criteria:
inclusion criteria: * must be ≥18 years of age. * signed an informed consent form (icf) indicating that the subject understands the purpose of and procedures required for the study. * having a bmi \>30kg/m2. * affiliated to health insurance regimen. * having undergone laparoscopic digestive surgery exclusion criteria: * pregnancy or breastfeeding. * patient under guardianship or unable to give consent. * people particularly protected by french law. * having undergone laparoscopic digestive surgery with ileostomy or ostomy closure.

Keywords: laparoscopy eventration abdominal support belt
the incidence of the intravascular injection during s1 transforaminal epidural steroid injection in two approaches: medial vs lateral in anteroposterior view

Conditions: Lumbosacral Radicular Pain

Summary: lumbosacral transforaminal epidural steroid injection (tfesi) is helpful for the treatment of lumbosacral radicular pain, but in case of intravascular injection, infrequently serious complication can be developed. against this backdrop, if there is any difference of frequency of intravascular injection incidence during s1 (sacrum 1) tfesi between method using medial approach and method using lateral approach in anteroposterior view, the result can be crucial factor in selecting the approach. in addition, appropriate volume of injection will be checked in each approach.


Eligibility criteria:
inclusion criteria: 1. adult patients (20-80 years of age) who were scheduled to receive s1 transforaminal epidural steroid injection for lumbosacral radicular pain at pain management clinic exclusion criteria: 1. pregnancy 2. coagulopathy 3. systemic infection 4. any active infection at the injection site 5. history of allergy to contrast media, local anesthetics, corticosteroid 6. patients unable to communicate or patients with cognitive dysfunction
impact of mobile app-based exercises on rectus diastasis in women undergoing cesarean birth

Conditions: Diastasis Recti and Weakness of the Linea Alba

Summary: diastasis recti abdominis, or rectus diastasis, is the separation of the two parts of the rectus abdominis muscle along the midline of the linea alba, without any visible defect in the fascia. diastasis recti abdominis is most frequent during pregnancy and postpartum especially, after cesarean birth.

cesarean births were linked to significant post-operative changes in the thickness of abdominal fasciae and muscles when compared to vaginal births and these changes may be involved in the higher rates of diastasis recti post-cesarean births. managing diastasis recti abdominis begins with its diagnosis, followed by targeted interventions. diagnosis usually involves manual palpation to estimate the gap between the rectus abdominis muscles along the tendinous sheet of the linea alba. updated imaging techniques, such as magnetic resonance imaging (mri) and ultrasound, are now more frequently used for diagnosis. treatment either surgical or conservative; emphasizes physical therapy and personalized exercise programs. this method targets strengthening specific core muscles, such as the transverse abdominis and the pelvic floor.

Eligibility criteria:
inclusion criteria: * first-time mothers who delivered by a cesarean birth * post-cesarean women between 25 and 35 years old * women with a diastasis recti of at least 1 cm separation above the umbilicus and at least 0.5 cm separation below the umbilicus exclusion criteria: * first-time mothers who delivered by a vaginal birth * multiparous mothers * those who have not a diastasis recti * mothers under 25 years old and those above 35 years old
a 6-month consumer behavior study of a self-management system (0803-084)(completed)

Conditions: Hypercholesterolemia

Summary: the purpose of this study is to evaluate the ability of patients with intermediate risk of heart disease to appropriately use a self-management system.

the duration of treatment is 6 months.

Eligibility criteria:
inclusion criteria: * must be able to read and understand english without assistance. * for males: minimum age 45 years and maximum age n/a (no limit). * for females: minimum age 55 years and maximum age n/a (no limit). exclusion criteria: * pregnant or nursing * drug allergy

Keywords: high blood cholesterol levels
turkish version of the brief-bestest scale

Conditions: Stroke Patients

Summary: the aim of this study is to investigate the validity and reliability of the turkish version of the brief-bestest (short bestest) scale in stroke patients.

brief balance evaluation systems test (brief-bestest) is a short version of the balance evaluation systems test (bestest). balance assessment systems test (bestest) the balance assessment systems test developed by horak consists of 6 sub-sections that evaluate the systems related to balance; 1) biomechanical limitations, 2) stability limit, 3) postural responses, 4) intuitive postural adjustments, 5) sensory orientation and 6) walking. it consists of 36 tests in total. each question is rated between 0-3. the highest score that can be obtained is 108. low test scores show that the balance is disturbed. bestest has been found to be reliable among raters evaluating a cohort of individuals with and without various neurological diagnoses. in studies conducted, it was stated that bestest is reliable when compared to other scales evaluating balance. the necessary permissions have been obtained from the authors for short bestest, whose validity and reliability features will be tested, and the translation process to turkish has been completed and the survey has been finalized. the basis for the use of special tools such as the scale is to prove the usability of the tool in the sample group to which it will be applied. the first step for this is the translation stage from the original language to the other language. at the stage of translation into turkish, two experts who knew a good level of english translated the questionnaire from english into turkish. these translations have been translated back into turkish by two native speakers of english and distant medical subjects. in addition, these translations were re-examined by the researchers and turned into a single form. this form was sent to five specialists in the field, checking the content and compliance with turkish was evaluated. with the opinion of experts, the scale was finalized. the study will include individuals over 40 years of age who have been diagnosed with an ischemic or hemorhagic stroke, who applied to the kırıkkale university faculty of medicine physical therapy and rehabilitation hospital.

Eligibility criteria:
inclusion criteria: * being 40 years old or older, * diagnosis of stroke, * no cooperation and communication problems * to be able to walk 10 m independently with or without an auxiliary device exclusion criteria: * another neurological or orthopedic problem other than stroke that will affect functionality and balance * individuals with advanced contraindications for cardiovascular disease and mobilization will not be included in the study.

Keywords: brief bestest stroke patients turkish version