Kornimate/medical-research-clean huggingface dataset:
application of 68ga-pentixafor pet/ct in primary aldosteronism and pre-postoperative of saae

Conditions: Positron-Emission Tomography

Summary: primary aldosteronism is the most common cause of secondary hypertension. the two main types of primary aldosteronism are aldosteronoma(30%) and adrenal hyperplasia(60%). the gold standard that determines the diagnosis and treatment strategy of primary aldosteronism is adrenal vein sampling(avs), but the success rate is only about 80%. using cxcr4 as a probe for 68ga-pentixafor pet/ct imaging can guide the classification diagnosis and treatment strategy of primary aldosteronism, which is a favorable supplement to avs. superselective adrenal artery embolization(saae) and laparoscopy are the main operation treatments for primary aldosteronism. saae is an invasive interventional operation. it is a novel way to evaluate the changes in the structure and function of adrenal tissue pre-postoperative saae by using the changes in 68ga-pentixafor pet/ct imaging.

primary aldosteronism: hypertension is divided into primary hypertension and secondary hypertension. secondary hypertension refers to hypertension with clear etiology. when the etiology is identified and effectively removed or controlled, hypertension as a secondary symptom can be cured or significantly relieved. the most common secondary hypertension is primary aldosteronism. primary aldosteronism is due to excessive aldosterone secretion in the adrenal cortex, characterized by clinical syndromes of hyperaldosteronism, low renin activity, hypertension and hypokalemia. compared with essential hypertension, the risk of cardiovascular and cerebrovascular events and the risk of target organ damage in patients with primary aldosteronism were significantly increased. on the contrary, early detection and treatment mean better blood pressure control, lighter target organ damage and better clinical outcomes. the two main types of primary aldosteronism are aldosteronoma(30%) and adrenal hyperplasia(60%). the gold standard that determines the diagnosis and treatment strategy of primary aldosteronism is adrenal vein sampling (avs), but the success rate is only about 80 %. therefore, it is necessary to explore a non-invasive examination method as a beneficial supplement to avs.

Eligibility criteria:
inclusion criteria: * adult population (aged 18 years or order); * patients with suspected or new diagnosed primary aldosteronism (supporting evidence may include mri, ct, laboratory tests); * patients who had scheduled 68ga-bnu-psma pet/ct scan; * patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the clinical research ethics committee; * healthy volunteers(aged 18 years or order). exclusion criteria: * patients with pregnancy; * the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.
research on the intervention of vr-based emotion regulation technology on adolescent non-suicide self-injury behavior

Conditions: Non-suicidal Self-injury

Summary: non suicidal self injury (nssi) has become a serious social and public health problem allover the world, and the incidence rate is increasing year by year. although the aim of nssi is not to suicide, but its negative impact is extremely serious, which will seriously threaten the physical and mental health of adolescents. virtual reality (vr), a computer simulation technology, can enable people to enter and experience the artificial virtual world in an immersive way, has been used for the auxiliary treatment of anxiety disorder, post-traumatic stress disorder and other diseases. this study explored the impact of vr on the depression and mental health of nssi adolescents, so as to reduce the incidence of non-suicide self-injury behavior in nssi adolescent patients and improve the quality of life of such patients.


Eligibility criteria:
inclusion criteria: * according to the diagnostic criteria of nssi in the fifth edition of the diagnostic and statistical manual of mental disorders. * have a past history of non-suicidal self-injury behavior. * no virtual reality technology intervention before enrollment. * age: ≥ 18 to\<24. exclusion criteria: * those who have serious physical diseases * those who cannot cooperate with the completion of virtual reality technology finally complete the intervention content\<50%.

Keywords: non-suicidal self-injury virtual reality technology adolescent
a randomized trial of changing medication adherence in hypertensive african-american patients

Conditions: Hypertension

Summary: the long-term objective is to determine whether better adherence to prescribed medications can be achieved through positive affect induction and self-affirmation leading to reduction in hypertension-related outcomes such as end-stage renal disease, stroke, and cardiovascular mortality among african american patients with poorly controlled hypertension.

the objective of this randomized trial is to evaluate, among african american patients with poorly controlled hypertension, whether a novel intervention of positive affect induction and self-affirmation is more effective than usual care in increasing adherence to prescribed antihypertensive medications. the main outcome will be the change in medication adherence rate from enrollment to 12 months, which is defined as percentage (%) of prescribed doses taken by the patient during the interval of observation as measured by electronic medication event monitoring system (mems). 2. secondary objectives 1. to determine, among african american patients with poorly controlled hypertension, the extent to which positive affect induction and self-affirmation influence patients' self-efficacy. 2. to determine, among african american patients with poorly controlled hypertension, the extent to which positive affect induction and self-affirmation influence medication adherence in those with significant depressive symptomatology (ces-d score \> 16). 3. to determine, among african-american patients with poorly controlled hypertension, the extent to which positive affect induction and self-affirmation influence blood pressure control. 4. to explore the health beliefs of hypertensive african-american patients, regarding the meaning, causes and treatment of hypertension. in addition, the factors that facilitate and prevent adherence to prescribed antihypertensive medications will also be explored using a qualitative approach.

Eligibility criteria:
inclusion criteria: 1. patients must be self-identified as african-americans. 2. all patients must be aged 18 years and older. 3. all patients must be diagnosed as having hypertension: for this project, hypertension will be defined according to the widely accepted criteria of the 6th joint national committee (jnc vi) guidelines on prevention, detection, evaluation and treatment of hypertension, which is a systolic blood pressure \> 140 mm hg or a diastolic blood pressure \> 90 mm hg or if participants are taking any prescribed antihypertensive medication. 4. patients must be able to provide informed consent in english. exclusion criteria: 1. patients who are unable to walk several blocks for any reason. 2. patients who refused to participate 3. patients who are unable to provide informed consent.

Keywords: african-american hypertension medication adherence risk reduction
effects of kinesio taping on hip abductor muscle strength and emg activity

Conditions: Chronic Ankle Instability

Summary: athletes with chronic ankle instability tend to develop glutei muscle weakness. this weakness makes the lower limb prone to injuries. kinesio tape (kt) may assist this muscle in performing its functions thus preventing injuries.

the aim was to study the effects of kinesio tape on hip abductor muscle strength and emg activity. pretest-posttest experimental design was used. the study was conducted in the research lab of the university. thirty-four athletes with a mean age of 22.08 years participated in the study. for the experimental group kinesio tape and for the control group micropore tape (mt) was applied over gluteus medius (gm) muscle. gm muscle's strength and emg activity were noted in supine and during the single-leg squat test (slst) respectively before and after the intervention. hip abductor muscle strength measured through a maximum voluntary isometric contraction (mvic) and gm activation measured through emg. handheld dynamometer (lafayette manual muscle test system), power lab emg system.

Eligibility criteria:
inclusion criteria: * repeated episodes of giving way after an initial ankle sprain, * a history of at least 2 ankle sprains to the same side without injury to the contralateral ankle in the last 2 years, * no history of other trauma to the lower extremities for the past 3 months prior to the study, * participants also needed to be capable of full weight-bearing without analgia, * subjectively reported that functional use of ankle had plateaued since the last injury. exclusion criteria: * participants having a history of ankle fracture, knee ligament injury, back or lower limb surgery, neuromuscular disease, or current neurological deficit, * currently receiving ankle rehabilitation were excluded from the study.

Keywords: chronic ankle instability hip abductors kinesio taping muscle strength emg
yjp-14 capsules for the treatment of endothelial dysfunction in patients with diabetes mellitus

Conditions: Diabetic Complication

Summary: the purpose of this study is to evaluate the safety and efficacy of yjp-14 capsules for the treatment of endothelial dysfunction in patients with diabetes mellitus.

the primary purpose of this study is to demonstrate superior effect of yjp-14 three doses, 25, 50 and 100 mg t.i.d on endothelial dysfunction in diabetes mellitus indicated as mean change difference of flow-mediated dilation (fmd), compared to placebo group after treatment of 12 weeks. the secondary purposes of this study are divided into three as follows; * clinically significant effect of yjp-14 three doses, 25, 50 and 100 mg t.i.d on endothelial dysfunction in diabetes mellitus indicated as mean change difference of fmd, compared to placebo group after treatment of 8 weeks. * clinically significant effect of yjp-14 three doses, 25, 50 and 100 mg t.i.d on insulin resistance in diabetes mellitus indicated as mean change difference of homeostasis model assessment-insulin resistance (homa-ir), compared to placebo group after treatment of 4, 8 and 12 weeks. * clinically significant effect of yjp-14 three doses, 25, 50 and 100 mg t.i.d on mean change difference of blood pressure in diabetes mellitus, compared to placebo group after treatment of 4, 8 and 12 weeks. the exploratory purposes of this study are divided into two as follows; * clinically significant effect of yjp-14 three doses, 25, 50 and 100 mg t.i.d on blood glucose level in diabetes mellitus indicated as mean change difference of hba1c, compared to placebo group after treatment of 12 weeks. * clinically significant effect of yjp-14 three doses, 25, 50 and 100 mg t.i.d on vascular stiffness in diabetes mellitus indicated as mean change difference of blood lipids (ldl, hdl and tg), compared to placebo group after treatment of 12 weeks.

Eligibility criteria:
inclusion criteria: adult-onset dm (defined as fasting glucose greater than 125 mg/dl or by ongoing treatment with an oral hypoglycemic agent), endothelial dysfunction: fmd below 6.7%, ldl cholesterol level less than 140 mg/dl, patients agreed to informed consent form exclusion criteria: (key exclusion criteria) uncontrolled arterial hypertension (above 139/90 mmhg) or hypotension (below 80/50 mmhg), severe diabetic complication: diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic vascular complications

Keywords: the treatment of diabetic complication
the saint francis remote ischemic preconditioning trial (safr)

Conditions: Coronary Artery Disease

Summary: this study tests the hypothesis that repeated inflation of a blood pressure cuff on the arm will improve results of coronary stent implantation by: * reducing chest pain and electrocardiogram changes during balloon inflation to place the stent * reducing leakage of heart muscle protein(troponin) into the blood stream after stent placement, indicated reduced damage to heart muscle during stent implantation * increases in molecules in the blood that promote dilation of arteries * reduced evidence of heart muscle damage on mri immediately after stenting * improved patient outcomes over six months with fewer adverse cardiovascular events(heart attack, acute coronary syndrome,renarrowing of the stented artery, heart failure, death, stroke, transient ischemic attack) * improved heart structure and function at 6 months after stenting


Eligibility criteria:
inclusion criteria: * patients with stable chronic coronary artery disease scheduled for elective percutaneous intervention. exclusion criteria: * recent (1 month) myocardial infarction * acute coronary syndrome * chest pain at res * estimated glomerular filtration rate(gfr)\<45 ml/min/1.73 m2 * frequent premature atrial or ventricular contractions or atrial fibrillation * any contraindication to mri including implanted non mri compatible medical devices or ferromagnetic materials such as shrapnel * inability to breath-hold * severe claustrophobia * deafness * persistent tremor * inability to follow instructions.

Keywords: coronary atherosclerosis percutaneous coronary intervention coronary stenting coronary stenosis remote ischemic preconditioning
a prospective, observational, multicenter study of patients following initiation of a new course of treatment for overactive bladder (oab)

Conditions: Urinary Bladder Overactive; Overactive Bladder; Urinary Bladder Diseases; Urologic Diseases

Summary: a study to identify factors that are associated with improved effectiveness in pharmacologic therapy of overactive bladder, from the patient perspective primarily measured by oab-q-sf (overactive bladder questionnaire short form)


Eligibility criteria:
inclusion criteria: * diagnosed with oab (with or without urgency incontinence) by the treating hcp, with symptoms for at least three months prior to study enrollment * initiating a new course of treatment with mirabegron or antimuscarinic medication (including patch formulation) for oab, which may be first course of any treatment for oab, restart or switch from one drug to another * willing and able to complete pro questionnaires with minimal assistance exclusion criteria: * current participation in clinical trials of oab * use of more than one oab medication at time of enrollment * patients whose oab has been treated with onabotulinumtoxina, sacral neuromodulation, percutaneous tibial nerve stimulation, external beam radiation (xrt), stents, surgery, or intermittent catheterization prior to or at time of enrollment * neurologic conditions associated with oab symptoms * patients residing in a nursing home

Keywords: betanis® myrbetriq® quality of life antimuscarinics betmiga® overactive bladder observational
effects of motivating people with schizophrenia to exercise

Conditions: Schizophrenia

Summary: this study will evaluate the impact of motivational guidance to exercise on people with schizophrenia, based on their participation in a walking program.

schizophrenia is a chronic brain disorder that affects about 1% of americans. people with schizophrenia experience extreme paranoia, often claiming that they hear voices not heard by others and that others are invading or controlling their minds with the intent to hurt them. more specific symptoms include hallucinations, delusional behaviors, disordered movements, and decreased ability to comprehend and apply information to everyday activities. the severity of these symptoms makes self-care and regular exercise difficult for people with schizophrenia. the fatality rate from diabetes, heart disease, and other obesity-related illnesses is significantly higher in people with schizophrenia. exercise is known to reduce health problems associated with obesity, yet few studies have encouraged exercise as a treatment method for improving the health of those with schizophrenia. furthermore, the long-term physical and mental effects of consistent exercise on people with schizophrenia are not well-known. this study will evaluate the impact of motivational guidance to exercise on people with schizophrenia, based on their attendance, persistence, and compliance to a walking program. participants in this study will be randomly assigned to one of two groups. both groups will continue their regular medications and treatments throughout the study. upon entry, members of both groups will complete the same two forms concerning attitudes toward exercise. group 1 participants will attend weekly 1-hour exercise information sessions for 4 weeks. group 2 participants will attend weekly 1-hour general health information sessions for the same 4 weeks. participants of both groups will then take part in identical 16-week walking programs. the walking program will consist of three 30- to 50-minute walks per week, including 10 minutes of warm up and 10 minutes of cool down stretching. all participants will gradually increase their walking time from 5 minutes to 30 minutes during the program. at the completion of the walking programs, participants of both groups will complete repeat forms about their attitudes toward exercise. there will be no follow-up visits for the participants.

Eligibility criteria:
inclusion criteria: * meets dsm-iv criteria for schizophrenia * speaks english * stable medication regimen * able to receive medical clearance for moderate exercise exclusion criteria: * hospitalized within 1 year of study entry for angina, heart attack, or cardiac surgery * diagnosed with congestive heart failure * has a pacemaker * heart rate less than 50 bpm or more than 100 bpm at rest * uncontrolled hypertension * history of spinal or hip fracture * unable to walk or move around without assistance * any other medical condition, in the opinion of primary care provider, that would prevent safe participation in the study

Keywords: exercise group counseling obesity
elonva in combination with hp-fsh versus elonva with low dose hcg

Conditions: Infertility

Summary: the study compares in a randomized controlled way two stimulation methods. one of these stimulation methods implements a new insight in ovarian follicular growth. if this novel method of stimulation proves to be as efficient as the classical stimulation protocols, there might be a dramatic reduction of the costs of the medical therapy in ivf, thus reducing also the overall ivf costs significantly.


Eligibility criteria:
inclusion criteria: * ivf/icsi patients * cycle 1, 2, 3, 4 exclusion criteria: * pcos * endocrinological diseases

Keywords: ivf ovarian stimulation low dose hcg hp-fsh corifollitropin alfa costs of ivf
a study evaluating the relative bioavailability and food effect of a tablet formulation of vx-147

Conditions: Focal Segmental Glomerulosclerosis (FSGS)

Summary: the purpose of the study is to evaluate the relative bioavailability (ba) and the effect of food on the pharmacokinetics (pk), and the safety and tolerability of vx-147 test tablet formulation.

this clinical trial information was submitted voluntarily under the applicable law and, therefore, certain submission deadlines may not apply. (that is, clinical trial information for this applicable clinical trial was submitted under section 402(j)(4)(a) of the public health service act and 42 cfr 11.60 and is not subject to the deadlines established by sections 402(j)(2) and (3) of the public health service act or 42 cfr 11.24 and 11.44.).

Eligibility criteria:
key inclusion criteria: * body mass index (bmi) of 18.0 to 32.0 kilogram per square meter (kg/m\^2), inclusive * a total body weight greater than 50 kg key exclusion criteria: * history of febrile illness or other acute illness that has not fully resolved within 14 days before the first dose of study drug * any condition possibly affecting drug absorption other protocol defined inclusion/exclusion criteria may apply.
intelligent personal assistant for managing depression in homebound older adults

Conditions: Aging; Physical Dependence

Summary: the purpose of this study is to design a companion booklet and pilot test it with a voice-controlled intelligent personal assistants (vipa), like google home or amazon alexa, to provide homebound older adult patients with skills and tools to help manage social isolation.

the objective of this pilot study is to design a companion booklet and pilot test it with a voice-controlled intelligent personal assistant (vipa), google home or amazon alexa, to provide patients with skills and tools to help manage their social isolation. the companion booklet is a document that will be created using feedback obtained from a panel of geriatric experts, highlighting features of the vipa that may be most beneficial to socially-isolated older adults. it will be submitted to the irb for approval once finalized. the specific aims of this project are to: aim 1: design a companion booklet to be used in conjunction with a vipa (google home/amazon alexa) for improving social isolation and communication among homebound older adults, defined as someone who is unable to leave the home without assistance of a device or another person, due to a physical or cognitive condition. aim 2: assess the feasibility and implementation of the vipa (google home/amazon alexa) and the companion booklet and its impact on clinical and functional outcomes for older adults with social isolation.

Eligibility criteria:
inclusion criteria: * adults aged 65 years or older; * homebound patients of the northwestern medicine geriatrics program; * english-speaking; and * able to verbally consent exclusion criteria: * condition that limits ability to consent, such as severe cognitive impairment or lack of english proficiency * less than 65 years of age

Keywords: social isolation loneliness older adults homebound
transcutaneous po2, transcutaneous pco2 and central venous so2 variations to define fluid responsiveness

Conditions: Hypotension; Shock; Fluid Challenge; Fluid Responsiveness

Summary: fluid challenge is often carried out in critical ill patients. its responsiveness usually requires invasive monitoring. to use non-invasive methods is very tempting. investigators hypothesize that transcutaneous po2,transcutaneous pco2 and central venous so2 variations provide feasible estimation on fluid responsiveness in critical ill patients.


Eligibility criteria:
inclusion criteria: * 18 years and older icu patients; * septic shock; * monitored with picco or swan-ganz catheter; * the decision of fluid challenge made by the treating physician; exclusion criteria: * evidence of fluid overload; * pregnancy