Kornimate/medical-research-clean huggingface dataset:
the effect of combined red and infrared lasers on histopathology collagen formation in diabetic foot ulcer

Conditions: Diabetic Foot; Wound Heal; Collagen Diseases

Summary: objective: investigate the effect of combined red and infrared lasers on histopathology collagen formation in diabetic foot ulcer participants: the forty five patients will assigned randomly into three equal groups, each group consist of 15 patients, group a received laser therapy in sequential mode, group b received laser therapy in separate mode and the control group c receive conventional wound care treatment

objective: investigate the effect of combined red and infrared lasers on histopathology collagen formation in diabetic foot ulcer participants: the forty five patients will assigned randomly into three equal groups, each group consist of 15 patients, group a received laser therapy in sequential mode, group b received laser therapy in separate mode and the control group c receive traditional wound care outcomes: the primary outcomes were the wound surface area measurement, % of wound complete closure and % of collage formation before and after receiving the treatment protocol for two consequetive months

Eligibility criteria:
inclusion criteria: * aged between 18 and 60 years; both gender; diabetic patients type ii; ulcer lasting longer than two months; diabetic foot ulcer (dfu) grade 1 (superficial diabetic ulcer, ulcer limited to the dermis, not extending to the subcutis) or grade 2 (ulcer of the skin extending through the subcutis with exposed tendon or bone and without osteomyelitis or abscess formation) according to the wagner classification exclusion criteria: * patients with fixed ankle deformity as charcot foot or stiffness; patients with any type of osteomyelitis associated with dfu; the presence of active infection requiring hospitalization, gangrene, systemic diseases such as collagen-vascular diseases, renal failure, evidence of ischemia; bmi \< 30 kg/m2 as obesity can cause poor perfusion due to vascular insufficiencies; an altered population of immune mediators may lengthen the inflammatory process \& decrease oxygenation of subcutaneous adipose tissue which is liable to be infected

Keywords: infrared laser red laser chronic diabetic foot ulcer collagen formation
physiological and oral dental parameters of young child

Conditions: Odontology

Summary: the aim of this study is to measure some oral and maxillofacial physiological parameters, with a view to creating a modular prototype articulator from young children to adolescents by 3d printing.

in the dental field, the articulators present different interests during the diagnostic and treatments of the dental diseases. thus they are used to perform dental prostheses, pre-orthodontic analysis or in the context of dysfunction of the manducatory apparatus. many children affecting with genetic disease need prosthetic rehabilitation. however, none commercial articulators are adaptable to children. consequently little dental prosthetic are taken before adolescence, or even adulthood. the aim of this study is to measure some oral and maxillofacial physiological parameters, with a view to creating a modular prototype articulator from young children to adolescents by 3d printing. on average, 30 children per week visit the dental department of reims chu for dental screening or orthodontic diagnosis. from this cohort, an epidemiological study will be carried out. it will concern different physiological parameters of the face and the oral cavity necessary to make a prototype articulator. ideally, the creation of a modular articulator to monitor the growth of a child would remove a number of diagnostic locks, therapeutic and technical.

Eligibility criteria:
inclusion criteria: first 30 children in each age group (\[3; 6 \[; \[6; 9 \[; \[9; 12\]) presenting to the odontology division as part of a first dental care or orthodontic consultation. exclusion criteria: * any child consulting to the odontology department in emergencies. * any child coming out of the weight-of- height growth curve. for example, a child below is considered to have hypo-development. conversely, a child located above the growth curve is considered to be hyper-developed. * any child with absence of at least 2 teeth per quadrant whether it is a genetic etiology (agenesis), infectious (avulsion) or traumatic (expulsion). * any child with a maxillofacial malformation generating disorders of the face development (ex: child with a cleft palate ...) * any child presenting a class iii of angle. indeed the intermaxillary ratios being reversed, a hypo-development of the maxillary is often observed. * any child with a cognitive impairment that limits the understanding of the examination undertaken. * any non-cooperating child

Keywords: child growth physiological parameters face maxillary
a study of amivantamab and capmatinib combination therapy in unresectable metastatic non-small cell lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: the purpose of this study is to identify the recommended phase 2 combination dose (rp2cd\[s\]) of the amivantamab and capmatinib combination therapy in participants with non-small cell lung cancer (nsclc) in phase 1 (combination dose selection), and to evaluate the antitumor effect of the amivantamab and capmatinib combination therapy in mesenchymal-epithelial transition (met) exon 14 skipping mutation and met amplified nsclc, when administered at the selected rp2cd(s) in phase 2 (expansion).


Eligibility criteria:
inclusion criteria: * previously diagnosed with histologically or cytologically confirmed unresectable stage iv (metastatic) non-small cell lung cancer (nsclc) (any histology) * may have: definitively, locally treated brain metastases that are clinically stable and asymptomatic for greater than (\>) 2 weeks and who are off or receiving low-dose corticosteroid treatment (less than or equal to \[\<=\]10 milligrams (mg) prednisone or equivalent) for at least 2 weeks prior to start of study treatment * may have a prior malignancy (other than the disease under study) the natural history or treatment of which is unlikely to interfere with any study endpoints of safety or the efficacy of the study treatment(s) * have an eastern cooperative oncology group (ecog) performance status of 0 or 1 * a participant of childbearing potential must have a negative serum pregnancy test at screening and within 72 hours of the first dose of study treatment and must agree to further serum or urine pregnancy tests during the study exclusion criteria: * medical history of (non-infectious) interstitial lung disease (ild)/pneumonitis, or has current ild/pneumonitis, or where suspected ild/pneumonitis cannot be ruled out by imaging at screening * participant has impairment of the gastrointestinal function that could affect absorption of capmatinib or is unable or unwilling to swallow tablets * participant has symptomatic central nervous system (cns) metastases which are neurologically unstable or have required increasing doses of steroids \>10 mg prednisone or equivalent within the 2 weeks prior to study entry to manage cns symptoms * participant has uncontrolled tumor-related pain: symptomatic lesions amenable to palliative radiotherapy (example, bone metastases, or metastases causing nerve impingement) should be treated more than 7 days prior to the administration of the first study treatment
dermal wound closure using silkam®

Conditions: Contusions; Incision; Laceration

Summary: assessment of performance of silkam® suture material for skin closure. a prospective, single center, single arm, observational study in daily practice.

the prospective, monocentric, single-arm, observational post market clinical follow-up (pmcf) study is done to continue to evaluate the safety and performance of silkam® suture material for skin closure under clinical routine. safety and effectiveness parameters commonly used in skin closure are to be used to evaluate the performance of the suture material. the aim of this non interventional study is to collect systematically and proactively different clinical parameters regarding safety, effectiveness and performance of silkam® suture material under the daily routine clinical practice when used for skin closure as intended.

Eligibility criteria:
inclusion criteria: * adult and paediatric patients undergoing skin closure using silkam® as suture material. * written informed consent regarding the data collection for the pmcf study. exclusion criteria: * pregnancy * visible dirty wounds * patients taking medication that might affect wound healing * patients with hypersensitivity or allergy to the suture material
postoperative sore throat: interest of the videolaryngoscope

Conditions: Sore-throat; Anesthesia; Postoperative Pain; Tracheal Intubation Morbidity

Summary: postoperative sore throat is a complication of orotracheal intubation. the aim of our study was to assess the impact of videolaryngoscopy on postoperative sore throat during the first 24 hours following surgery. this was a prospective, randomized study, over a period of 9 months. the investigators included 136 patients with non-difficult airway, classified asa i to iii and over 18 years old. the patients were randomized into 2 groups: the vl group including 70 patients intubated with direct laryngoscopy and the ld group including 66 patients intubated with videolaryngoscopy.

the investigators monitored blood pressure, ecg, saturation in oxygen, capnograph, temperature and curarization. they also monitored cuff pressure using manometer. the investigators pre-oxygenated the patients until the fractional expired oxygen was over 90%, then induced anaesthesia using either 2.5 to 3.5 mg/kg of propofol or 0.3 to 0.4 mg/kg of etomidate, then 1mg/kg of suxamethonium (in absence of contraindication). if modified crash induction was performed, the anaesthesiologist mentioned the opioid used. the investigators performed laryngoscopy using either a macintosh laryngoscope using a number 4 blade in ld group, or a mcgrath video-laryngoscope with a number 4 blade in vl group and a stylet when needed. women were intubated using number 7 tube and man using a 7.5 tube. they inflated the cuff with 7ml of air, and controlled pressure by manometer every 30 minutes in order to maintain it between 20 and 25 mmhg. the investigators ventilated patients with assisted controlled mode using a 6ml/kg of ideal weight volume, a 6 mmhg peep, a 50% inspired fraction of oxygen and a respiratory rate guaranteeing an end-expiratory co2 level between 35 and 40 mmhg. then, they administrated 4 mg of ondansetran in order to prevent postoperative nausea and vomiting (ponv). the investigators maintained anaesthesia using either isoflurane or sevoflurane, 0.1 μg/kg of sufentanil and 0.05 mg/kg of atracurium.

Eligibility criteria:
inclusion criteria: * patients aged over 18 years old; * patients with asa status 1, 2 or 3; * patients who underwent surgery with general anaesthesia and intubation; * written consent. exclusion criteria: * patients under corticosteroids; * pregnant women; * patient with at least two difficult intubation criteria or a limited mouth opening (under 2cm), difficult airway management history, upper airway tumour or cervical rachis trauma; * patients who had an otorhinolaryngologic infection in the last month, an intubation or endoscopy of upper airway in the last 48 hours, vomiting in the last 24 hours, a gastric tube in the last 24 hours or throat symptoms prior to surgery; * patients scheduled for a surgery implying a manipulation of upper airways; * patient scheduled for a surgery \> 2 hours.
interval training and cardio-metabolic health in overweight/obese girls

Conditions: Exercise Overtraining; Enjoyment; Cardiometabolic Syndrome; Obesity

Summary: the main purpose of this study is to compare the impact of 12-week moderate-intensity interval training (miit) versus combined miit with high-intensity interval training (hiit) on physical fitness, cardio metabolic, lipidomic, hematological and psychological characteristics in young overweight/obese girls.


Eligibility criteria:
inclusion criteria: * female gender, * overweight or obese according to the bmi classification, * age, 12 to 15 years, * personal or parental/guardian written consent exclusion criteria: * severe infectious or inﬂammatory diseases, * irregular menstrual cycles * participation in organized exercise training in the last 6 months or additional physical - * recreational activities, except physical education classes. * using medications, hormone therapy or dietary supplements

Keywords: interval training obesity overweight childhood cardiometabolic risk enjoyement lipidomics body composition physical fitness
remote home monitoring acute pancreatitis

Conditions: Acute Pancreatitis; Telemedicine; Healthdot; Patient Discharge; Monitoring

Summary: acute pancreatitis is an inflammation of the pancreas which causes abdominal pain and is the most common gastro-intestinal reason for acute hospitalization in western countries. because care for a mild acute pancreatitis is supportive, early discharge of patients with a predicted mild course of acute pancreatitis might be safe with the use of remote home monitoring. this might reduce the demand for hospital beds and allow patients to benefit from recovering in their home environment. therefore, the aim of this study is to assess the feasibility of a novel care pathway in which patients with a predicted mild course of acute pancreatitis are discharged early with remote home monitoring.


Eligibility criteria:
inclusion criteria: * have 2 out of 3 revised atlanta criteria for pancreatitis: * abdominal pain consistent with acute pancreatitis * serum lipase ≥ 3x upper limit normal (\> 159 u/l) * typical pancreatic abnormalities on imaging (ultrasound, ct or mri) * first episode of acute pancreatitis or a prior pancreatitis more than 3 months ago. * age ≥18 years, both men and women. * able and willing to provide written informed consent. * in possession of a working (smart)phone on which patient can be reached for the duration of participation (30 days). exclusion criteria: * chronic pancreatitis according to m-annheim criteria (20). * signs of severe pancreatitis at the moment of admission to the ge ward: * serum crp \> 150 mg/l * more than one sirs criteria: * temperature \ 38◦c * heart rate \> 90/min * respiratory rate \>20/min * leucocytes \ 12x109/l * mews (modified early warning score) ≥6 or in need of icu admission * living alone or in an institution (e.g. psychiatric ward or nursing home) * known sensitivity to medical adhesives * known pregnancy * have one or more of the following comorbidities: * heart failure (nyha class iii or iv) * copd (gold iii-iv) * kidney disease (\>g3b) and/or kidney replacement therapy * currently undergoing oncological treatment * use of immunosuppressants * dysregulated or poorly controlled insulin dependent diabetes * morbid obesity (bmi\>35 kg/m2) * implantable cardioverter defibrillator (icd) or pacemaker
safety and efficacy study of lambre laa closure device for treating af patients who cannot take warfarin

Conditions: Atrial Fibrillation

Summary: the aim of this study is to assess the efficacy, safety and performance of lambre left atrial appendage closure system in patients with non-valvular atrial fibrillation who cannot be treated with warfarin.


Eligibility criteria:
inclusion criteria: * age\>=18, chads2 score\>=1 * patients cannot be treated long-term with warfarin * eligible for clopidogrel and aspirin * provide written informed consent and agree to comply with required follow-ups exclusion criteria: * need to take warfarin * presence of rheumatic, degenerative or congenital valvular heart diseases * early stage or paroxysmal af * symptomatic patients with carotid artery disease (such as carotid stenosis\>=50%) * heart failure nyha grade iv * recent 30 days stroke or tia * presence of active sepsis or endocarditis * cardiac tumors or other malignancy with estimated life expectancy \<2 years * abnormal blood test; renal disfunction * laa removed or heart implant patients * patients have planned electrophysiological ablation or cardioversion 30 days post implantation of the lambre system * patients have history of mechanical prosthesis operation * patients who are pregnant, or desire to be pregnant during the during the study * participation in other trials * a known allergy to nitinol * patients will not be able to complete the trial esophageal ultrasonic exclusion criteria: * laa ostium \ =30mm * lvef \<30% * presence of thrombus in the heart * high risk pfo * mitral valve stenosis (valve area \<2 cm2

Keywords: lambre
investigation of anti-obesity properties of lactobacillus sakei in obese human subjects

Conditions: Obesity

Summary: in this study, we are going to investigate the efficacy of lactobacillus sakei on reduction of fat mass assessed by dexa compared to plaebo.

we are going to enroll subjects whose bmi is equal to higher than 25, and randomly assigned study material or placebo at 1:1 ratio. the treatment duration is 12 weeks.

Eligibility criteria:
inclusion criteria: * age 20-65 years * bmi equal to higher than 25 kg/m2 exclusion criteria: * under anti-obesity medication * uncontrolled diabetes * uncontrolled hypertension * any medications can influence to body weight such as thiazolidinedione, glp-1 analogue, sglt2 inhibitor, diuretics * thyroid function test abnormality * malignancy within 5 years * immune compromised hosts or under immune suppressants * antibiotics or probiotics withing 2 weeks * any intervention to reduce body weight within 6 months
comparison of sublingual misoprostol versus lidocaine spray for hysteroscopy

Conditions: Pain During Hysteroscopy

Summary: hysteroscopy is an instrument to visualize the interior walls of uterus (womb) and it enables the doctor to do minor operative procedures. although it causes little discomfort, sometimes it may be disturbing for the patient. this pain is usually perceived during the passage of the instrument through the cervix (neck of the womb). the investigators would like to minimize this pain by two drugs: misoprotol and lidocaine

outpatient or office hysteroscopy has become the 'gold standard' for the investigation of the intrauterine abnormalities. this minimal invasive modality provides brilliant and clear visualization of the entire uterine cavity and besides this, by the operative channel, minor procedures may easily be performed in the office setting which is priceless for the gynecologist. however, pain related to the procedure may make the procedure uncomfortable for the patient and the physician. together with the operative time, hysteroscope diameter is considered as the main factor influencing pain. the pain perceived during hysteroscopy may be reduced by using a smaller diameter hysteroscope or by using anesthesia, which decreases pain perception. in this prospective, randomized, double blind, placebo controlled study, we aim to compare the effectiveness of sublingual misoprostol versus lidocaine pump spray for pain relief during office hysteroscopy.

Eligibility criteria:
inclusion criteria: * premenopausal women in the proliferative phase of the menstrual cycle with no contraindication for hysteroscopy exclusion criteria: * vaginal bleeding at the time of the procedure * known sensitivity to lidocaine (amide group local anesthetics) or prostaglandins * epilepsy * significantly impaired respiratory or cardiac conduction functions * hypertension * glaucoma * renal failure * acute liver disease * uncontrolled diabetes mellitus * pregnancy or suspicion of pregnancy * pelvic inflammatory disease * cervical operation history * vaginismus.

Keywords: hysteroscopy misoprostol lidocaine visual analogue score
body composition reference data for preterm infants

Conditions: Preterm Birth

Summary: the american academy of pediatrics has recommended that growth in size (weight, length, and head circumference) and in body composition (fat and lean mass) in preterm infants should adhere as close as possible to the growth and body composition of a healthy infant in utero at the same gestational age. however, there are no body composition reference curves available at this time for the preterm infant population. the purpose of this study is to collect cross-sectional body composition data using air displacement plethysmography (pea pod infant body composition system, life measurement, inc) on approximately 240 preterm infants within 3 days of birth, for the purpose of generating means, standard deviations, and percentile values for total body fat mass, total fat free mass, and percent body fat for infants born at 30-36 weeks gestation. relatively healthy infants without evidence of growth retardation will be selected for form the reference sample. the goal is to generate a set of common reference curves to be used in clinical centers against which to compare body composition status for individual infants.


Eligibility criteria:
inclusion criteria: * appropriate for gestational age (aga), singleton, 30+0 and 36+6 weeks gestational age exclusion criteria: * congenital defects that affect growth * inability to tolerate room air for 5 minutes without desaturation or bradycardia * \<1 kg birth weight * parents did not provide consent
effects of myofascial release and neuromuscular training for pes anserine syndrome associated with knee osteoarthritis

Conditions: Knee Osteoarthritis; Pes Anserine Bursitis

Summary: a randomized control trial will be conducted at the outpatient department of dow institute of physical medicine and rehabilitation. a sample size of 80 is calculated using pass version 11 software. the subjects will be first screened and those who fulfill the inclusion criteria, will be asked to fill the consent form. after selection, the participants will be randomly allocated by the help of computer generated randomization sheet, into two groups i.e. experimental and the control group. the group a will be provided with the myofascial release along with the neuromuscular training whereas the group b will only receive the neuromuscular training. cold pack will be applied to both the groups. the neuromuscular training consists of warm-up phase, lunges, sideways exercises, wall squats, weight transfer exercises, step up and down and the cool down phase. total 12 sessions of 35 minutes each will be given to all the participants for about 4 weeks on alternate days. outcome measures will be analyzed by visual analogue scale (vas) for pain assessment, goniometry for range of motion and the knee injury and osteoarthritis outcome score (koos) to evaluate the functional assessment of the patients at the baseline and the post intervention.


Eligibility criteria:
inclusion criteria: * male and females both with the age between 40-60 years. * patients with unilateral or bilateral knee osteoarthritis with pes anserine syndrome. * patients with knee pain more than 3.4 cm on visual analogue scale as minimum cut of value. * kellgren and lawrence grade ii and iii on radiological findings. * duration of knee osteoarthritis more than 3 months (chronic). exclusion criteria: * patients with any neurological disorder. * knee deformities such as contractures, genu valgum and genu varum. * septic knee arthritis. * history of ligamentous injury or meniscal tear. * cancer or any other malignancy or bone tumor. * any history of previous lower limb arthroplasty or other knee surgery. * comorbid like diabetes mellitus. * inflammatory rheumatic disease (r.a).