Kornimate/medical-research-clean huggingface dataset:
effect of acetylcysteine in pediatric acute pyelonephritis.

Conditions: Pyelonephritis

Summary: in different studies, it has been shown that "antioxidant" utilization has favorable therapeutic effects not only on control of acute symptoms but also on prevention of delayed problems from acute and chronic pyelonephritis. according to the efficacy of acetylcysteine as a potent antioxidant, safety of this drug and side effects of similar or either less than placebo, this study was designed to evaluate the efficacy of this drug on inflammatory biomarkers of pediatric acute pyelonephritis. it is a triple-blind placebo controlled study on a population of 64 patients 1-16 years old that have "definite" or "probable" diagnosis of acute pyelonephritis in "mofid" hospital. after randomization, patients will be given acetylcysteine or placebo with dosing according to their weight. results of treatment are evaluated according to serum procalcitonin, c reactive protein and leukocyte count before drug prescription (baseline) and 5 days after drug prescription. side effects are also recorded in both groups. patients will be receiving their routine antimicrobial drugs in addition to acetylcysteine.


Eligibility criteria:
inclusion criteria: * patients between the ages of 1 and 16 * having the diagnosis of "definite" or "probable" urinary tract infection according to guidelines of "pediatric infectious disease research center exclusion criteria: * patients younger than 1 or older than 16 years old * patients without the diagnosis of "definite" or "probable" urinary tract infection according to guidelines of "pediatric infectious disease research center" * patients with acute/ chronic infectious or inflammatory diseases other than pyelonephritis.

Keywords: acute pyelonephritis acetylcysteine pediatric
clavicular shortening post-fracture - does it change? - a prospective study of 70 patients

Conditions: Stability of Clavicular Fractures Within the First 3 Weeks

Summary: in an attempt to answer if clavicular length changes after a fracture e.g. that any shortening becomes worse or better, 70 patients will be followed 3 times over 21 days using a novel ultrasound method.


Eligibility criteria:
inclusion criteria: all patients who sustain a displaced medial, mid and lateral clavicle fracture from march 2014 to august 2015 referred from slagelse and holbæk emergency departments are eligible. the last patients are seen end of mid-july 2015 given the 21 days of follow up. exclusion criteria: patients that have bilateral clavicle fractures and/or prior operations involving the clavicle are excluded. malignant diagnoses are excluded.
the effect of 'medical nutrition therapy' on post-bariatric hypoglycemia 2-4 years after gastric bypass surgery

Conditions: Hypoglycemia; Obesity, Morbid

Summary: this is a pilot study to explore the effect of 'medical nutritional therapy' in patients diagnosed with post-bariatric hypoglycemia (pbh), 2-4 years after gastric bypass surgery. the study is largely inspired by the findings presented in the meta-analyses from joslin diabetes center, where a treatment strategy is proposed to reduce the symptoms of pbh. this treatment strategy is mainly based on clinical observations and experience, while there is little or no objective data to support that this strategy improves pbh. the data from this pilot study can then be used to set up larger studies where a conclusion on treatment of pbh may be drawn.


Eligibility criteria:
inclusion criteria: * patient in nord-trøndelag 2-4 years after roux-en-y gastric bypass surgery * visits namsos outpatient clinic for follow-up. * having at least 3 symptoms of hypoglycemia presented in the dumping severity scale (dss). * at least one of these symptoms must be a neuroglycopenic symptom * all these symptoms have an intensity of 2 or 3 on dss. exclusion criteria: * severe surgery-related complication * revisional surgery * life threatening health conditions. * diabetes mellitus or other metabolic diseases * pregnancy or breast feeding

Keywords: gastric bypass diet therapy blood sugar variation quality of life
immunoinflammatory regulation of esketamine in septic patients

Conditions: Esketamine; Sepsis; Inflammatory Response; Immunosuppression

Summary: studies have shown that excessive systemic inflammatory response and concomitant immunosuppression are the main cause of early death in patients with sepsis. therefore, it is very important to reduce excessive inflammation and improve immunosuppression in the acute phase of sepsis. clinical studies have shown that esketamine combined with propofol for sedation has been proven to be safe and effective for septic patients in the icu due to its cardiovascular stability. previous studies have demonstrated that esketamine has anti-inflammatory effects against depression and surgical stress. our preliminary experimental studies have found that esketamine had strong anti-inflammatory effects in the acute phase of sepsis. however, it is not clear whether esketamine could reduce excessive inflammation and improve immunosuppression in septic patients primarily sedated with a continuous infusion of propofol. this intervention study is to investigate whether three consecutive days of intravenous esketamine infusions via infusion pump (0.07 mg/kg/h) could reduce excessive inflammation and improve immunosuppression in septic patients requiring mechanical ventilation in the icu under sedation primarily with propofol.


Eligibility criteria:
inclusion criteria: * 18 years old ≤ age ≤60 years old; * sofa score ≥2; * mechanical ventilation should be required for at least 24 hours when included in the study; * informed consent is obtained. exclusion criteria: * age \< 18 years old or ≥ 60 years old; * previous solid organ or bone marrow transplantation; * autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.), or hematologic malignancies (leukemia and lymphoma, etc.); * received radiotherapy or chemotherapy within the past 30 days, or received immunosuppressant drugs (tripterygium wilfordii, mycophenolate mofetil, cyclophosphamide, fk506, etc.), or continuous treatment with prednisolone more than 10 mg/day (or equivalent doses of the other hormones); * unstable angina pectoris or myocardial infarction in the past six months; * acute brain injury (traumatic brain injury, subarachnoid hemorrhage, acute ischemic stroke, acute intracranial hemorrhage, acute intracranial infection, etc.); * poorly controlled hypertension and congestive heart failure; * increased intraocular or intracranial pressure; * chronic kidney disease, received continuous renal replacement therapy in the past 30 days, or acute renal failure requiring crrt; * severe chronic liver disease (child-pugh class b or c); * alcohol dependence, mental illness or severe cognitive impairment; * pregnancy or lactation; * informed consent is not obtained.

Keywords: esketamine sepsis inflammatory response immunosuppression
study regarding the clinical efficacy of synatura® in patients with chronic bronchitis type copd

Conditions: Bronchitis, COPD

Summary: this study aims to examine the clinical efficacy of synatura in patients with chronic bronchitis type copd in korea.

synatura® is a drug commonly used to suppress cough and sputum in patients with acute upper respiratory tract infection and chronic inflammatory bronchitis. according to the phase iii studies conducted in korea, the safety and efficacy of synatura® on antitussive and expectorant effects were confirmed in patients with acute upper respiratory infection and chronic inflammatory bronchitis. however, no studies have been conducted for the effects of synatura® in patients with copd. copd is divided into emphysema type and chronic bronchitis type, while typical clinical symptoms of chronic bronchitis are cough and sputum. therefore, synatura®, which is effective for chronic bronchitis, is expected to be effective in patients with chronic bronchitis accompanied by copd.

Eligibility criteria:
inclusion criteria: 1. post bronchodilator fev1/fvc \< 0.7 2. smoking history of ≥10 packs per year 3. 40 to \<75 years of age 4. patients with symptoms of chronic bronchitis (in case they have symptoms of cough or sputum over 3 months) exclusion criteria: 1. patients with acute exacerbation 2. patients with pneumonia 3. patients with active tuberculosis 4. pregnant women 5. breast-feeding women 6. patients with fructose intolerance

Keywords: synatura chronic obstructive pulmonary disease ahn gook pharmaceuticals
peri-implantitis between periodontitis and nonperiodontitis sites with arp

Conditions: Peri-Implantitis

Summary: the goal of this observational study is to compare the prevalence of peri-implantitis between periodontitis and nonperiodontitis sites treated with alveolar ridge preservation. the main question it aims to answer is: • whether the occurrence of pi is associated with reasons for dental extraction because of periodontitis and nonperiodontitis after alveolar ridge preservation. researchers will compare the prevalence of peri-implantitis between periodontitis and nonperiodontitis sites treated with alveolar ridge preservation.


Eligibility criteria:
inclusion criteria 1. patients aged ≥ 20 years 2. patients who required tooth extraction and implant therapy 3. at least two bite-wing radiographs: baseline and at least a 6-month follow-up exclusion criteria 1. a medical condition as a contraindication to dental surgery, autoimmune disorder, immunosuppression, or uncontrolled diabetes (hba1c \> 7%); 2. ong-term nonsteroidal anti-inflammatory drug use 3. oral bisphosphonate therapy 4. pregnancy or lactation 5. the absence of follow-up bite-wing radiograph 6. cigarette consumption \>10 per day 7. a history of head and neck radiotherapy.

Keywords: peri-implantitis, periodontitis, alveolar ridge preservation
post-discharge monitoring of patients with heart failure

Conditions: Heart Failure

Summary: what is proposed in this project is to develop and evaluate the effectiveness of an online remote monitoring system that is easily accessible to patients so that professionals with experience in monitoring patients with heart failure (hf) can monitor signs and symptoms of decompensation of the disease, as well as self-care actions. a randomized, blind trial for outcome evaluation was designed that will include patients hospitalized for acute hf at a referral institution in cardiology in southern brazil. patients in the intervention group will be followed up with a remote monitoring system, accessible by device (computer, tablet and cell phone) connected to the internet, by checking for signs, symptoms and self-care actions in three moments during 30 days after hospital discharge. patients in the control group will follow up according to the routine of the hospital or physician assistant. the primary endpoint for assessing the efficacy of the system will be hospital readmission within 30 days (follow-up period). the information regarding the signs, symptoms and self-care of the patients will be monitored by the research team through an access schedule. the sample calculation points to the need to include a total of 142 patients (71 in each group). the data will be analyzed through descriptive and analytical statistics. it is hoped that the development of a remote monitoring system could be characterized as a strategy for the early detection of signs and symptoms of acute decompensation in hf patients, impacting on hospital readmission rates within 30 days after discharge. in addition, remote monitoring of signs and symptoms may promote improved adherence and self-care of patients. the scientific contribution will occur to the extent to which there is innovation in patient follow-up and feedback obtained from the patient's interaction with the system.


Eligibility criteria:
inclusion criteria: * with diagnosis of hf or hospitalized for acute hf exclusion criteria: * degenerative neurological diseases; * patients with renal / hepatic / pulmonary or systemic disease that may confuse the interpretation of findings or result in limited life expectancy; * surgical or therapeutic plan that may influence the follow-up; * pregnancy; * diagnosis of acute hf secondary to: sepsis, myocarditis, acute myocardial infarction, peripartum and other acute cause; * not be able to contact by phone.
phase ii trial for the treatment of relapsed osteosarcoma

Conditions: OSTEOSARCOMA

Summary: phase ii randomized study for the comparison of the gemcitabine plus docetaxel and the ifosfamide treatment of patients with relapsed osteosarcoma

patients with relapsed osteosarcoma will be randomized to receive gemcitabine plus docetaxel or high doses ifosfamide (continuous infusion) every 3 weeks, up to 6 weeks

Eligibility criteria:
inclusion criteria: * diagnosis of high grade osteosarcoma recurrence * resectable or unresectable recurrence disease within 24 months from the initial diagnosis * pleuro-pulmonary recurrence with more than 2 nodules within 24 months from the initial diagnosis * unresectable first relapse within 24 months from the initial diagnosis * resectable or unresectable second of further recurrence of high grade osteosarcoma * age at diagnosis at least 4years. * karnofsky performance status over 60%. * renal function and hepatic in normal limits for age. * l eft ejection ventricular fraction over 50%. * white blood cells over 3000 million/liter and platelets 100000 million/liter * birth potential female must agreed to contraception * signed written informed consent exclusion criteria: * contraindication to the use of any study drugs * mental, social and geographic conditions which fail to ensure adequate adherence to the study * hepatitis and human immunodeficiency virus active infection * pregnancy or breast-feeding * previous treatment with gemcitabine, docetaxel and ifosfamide
effect of progressive relaxation exercıses on dyspnea and comfort level in individuals with copd

Conditions: Copd; Dyspnea; Nursing Caries

Summary: the study is a randomised controlled experimental study conducted to examine the effect of progressive relaxation exercises on dyspnea and comfort level in individuals with chronic obstructive pulmonary disease. the study was conducted between january and august 2023 in the internal medicine clinic of izmir urla state hospital. stratified and block randomisation method was used in the study and 42 patients, 21 intervention group and 21 control group, were completed. patients in the intervention group received 30-minute progressive relaxation exercises for 6 weeks. patients in the control group did not receive any intervention other than standard care practices. the data of the study were collected by face-to-face interview method using the descriptive information form, medical research council dyspnea scale, general comfort scale-short form and patient follow-up form. descriptive statistics, shapiro wilk test, levene's test, mauchly's w test, independent sample t test, mann whitney u test, dependent sample t test, wilcoxon signed ranks test, friedman test, benferoni test and fisher's exact test were used to analyse the data obtained from the study. it was determined that the mean dyspnea level scores of the patients in the intervention group at week 6 were lower than the control group and this difference between the groups was statistically significant (p\<0.05). it was determined that the decrease in the mean comfort level scores of the patients in the intervention group according to the follow-up periods was statistically significant (p\<0.05). according to the results of the study, progressive relaxation exercises can be recommended as an effective nursing intervention to provide dyspnea management in patients with copd.


Eligibility criteria:
inclusion criteria: * 18 years of age and over * inpatient treatment in the internal medicine clinic of izmir urla state hospital * standardised mini mental test score ≥24 * dyspnea severity ≥2 according to the mmrc dyspnoea scale * diagnosed with stage ii and stage iii copd according to gold criteria * functional competence to participate in progressive relaxation exercises * able to access and use a smartphone * copd patients who agreed to participate in the study. exclusion criteria: * have any speech and hearing problems * lung disease other than copd, physical dependence and psychiatric illness diagnosed with * copd patients in the acute exacerbation period.
prospective trial of serial ct imaging for evaluation of dosimetric/volumetric changes during imrt for head/neck cancer

Conditions: Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma

Summary: anatomical changes that take place during intensity modulated radiation therapy (imrt) treatments for cancers of the head and neck cause significant dosimetric changes.

the investigator's hypothesis is that those patients with bulky head and neck cancers who undergo definitive radiation therapy with or without chemotherapy have changes in their dose distribution that lead to significant changes in dose to tumor and/or normal tissue. it is possible for these dosimetric changes could occur in either those patients who undergo resection or not. in this study those patients who have undergone a resection will be stratified separately for analysis, however, this study is not powered to detect a difference between the two groups. the rational for stratification into an operated group of patients is that these patients will also lose weight in treatment and will provide us a detection of the magnitude of change in dose caused by weight loss independent of tumor shrinkage.

Eligibility criteria:
inclusion criteria: * ajcc pathological stage i-iv cancers of the head and neck meeting the following criteria: * if gross total resection is performed it must be completed within 7 weeks of registration * site of tumor origin in the nasopharynx, oral cavity, oropharynx, parotid, larynx, or hypopharynx (excluding lip, or sinuses) * pretreatment evaluations required for eligibility include: * history and physical examination within four weeks prior to study entry * dental evaluation with management according to the guidelines in appendix iv prior to start of radiation * serum pregnancy test, if applicable, within one week prior to study entry; urine dipstick test on the first day of treatment * radiographic studies: pre-operative ct or mri of the primary tumor and neck for clinical staging is required * patients must be ≥ 18 years of age. * women of childbearing potential (wocbp) must be willing to consent to using effective contraception while on treatment. * pregnant women are ineligible as radiation therapy involves unforeseeable risks to the embryo or fetus. wocbp must have a negative serum or urine pregnancy test (minimum sensitivity 25 iu/l or equivalent units of human chorionic gonadotropin \[hcg\], or in accordance with local regulations, whichever is more sensitive). * patients must sign a study-specific informed consent form prior to registration. exclusion criteria: * histology positive for melanoma. * gross (visible or palpable) disease left after surgery. * less than gross total resection or patients requiring staged surgery. * prior head and neck radiotherapy. * women of childbearing potential (wocbp) who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period

Keywords: head and neck cancer head and neck squamous cell carcinoma intensity modulated radiation therapy imrt anatomic changes postoperative unresectable
prevalence of latent tuberculosis infection in health-care workers and students

Conditions: Tuberculosis; Tuberculosis, Pulmonary; Tuberculosis Infection; Latent Tuberculosis; Health Care Associated Infection

Summary: this study is a cross-sectional study that examines the prevalence of latent tuberculosis infection \[ltbi\], defined as individuals infected with mycobacterium tuberculosis with no clinical evidence of disease, and the possible risk factors of ltbi in a large cohort of health care workers (hcws) and students.

mycobacterium tuberculosis may develop symptoms and signs of disease or may have no clinical evidence of disease (latent tuberculosis infection \[ltbi\]). tb disease remains one of the major causes of morbidity and mortality in the world. a survey to assess the prevalence of the individuals with a ltbi and evaluate the potential main risk-factors will be performed on both hcws and students attending the hospital wards, trained at fondazione policlinico universitario a. gemelli irccs in rome. this study is a cross-sectional study that examines the prevalence of latent tuberculosis infection \[ltbi\], defined as individuals infected with mycobacterium tuberculosis (mt) with no clinical evidence of disease, and the possible risk factors of ltbi in a large cohort of health care workers (hcws) and students. the study will involve all hcws of fondazione policlinico universitario a. gemelli irccs in rome - a tertiary reference hospital with over 1,500 beds - and all students of all three-year and single-cycle degree courses, master's degree courses, graduate schools of the faculty of medicine and surgery of the catholic university of sacred heart in rome, trained at the fondazione policlinico universitario a. gemelli irccs. all enrolled participants, who will agree to participate to the study and answer the questionnaire, will respond a cross-sectional questionnaire survey through dedicated tablet. the survey will contain a brief explanation of the study aims and an invitation to respond to a 9 items multiple choice questionnaire.

Eligibility criteria:
inclusion criteria: * all health-care workers of fondazione policlinico universitario a. gemelli irccs in rome, * all students of all three-year and single-cycle degree courses, master's degree courses, graduate schools of the faculty of medicine and surgery of the catholic university of sacred heart in rome, trained at the fondazione policlinico universitario a. gemelli irccs, * written informed consent. exclusion criteria: * denied informed consent.

Keywords: latent tuberculosis infection health-care workers students survey
programme evaluation on effectiveness of the use of movement-based x 'elderspirituality - fu le mun sum' intervention to support elderly people with depressive symptoms

Conditions: Depression in Old Age

Summary: depression is one of the most common mood disorders in old age, and yet it is frequently under-detected and under-treated. adopting a train-the-trainer approach, this project intends to utilize the dance movement therapy (dmt), as intervention, to support elderly people with depressive symptoms.

in the present project, two evaluation studies will be conducted. the first study will evaluate the effectiveness of a train-the-trainer approach provided to frontline art development officers who will subsequently conduct interventions for the elderly. a participatory train-the-trainer approach will be adopted to develop a new intervention protocol by integrating body-movement therapeutic elements and a spiritual well-being enhancement group. in the second study, a quasi-experimental design will be adopted to examine the effectiveness of the movement-based x 'elderspirituality - fu le mun sum' intervention to support elderly people with depressive symptoms.

Eligibility criteria:
inclusion criteria: * aged 60 or above * physical mobility of at least the limbs and body * sufficient visual and auditory abilities to complete assessments * with a clinical diagnosis of depression or with depressive symptoms (measured as the sum of 4 dichotomous items of the geriatric depression scale) exclusion criteria: - a clinical diagnosis of severe illness that led to neurological deficits which limits the participation during the intervention

Keywords: depression dance movement therapy depressive symptoms older adults elderly ageing