Kornimate/medical-research-clean huggingface dataset:
the safety and efficacy of escitalopram in pediatric patients with major depressive disorder

Conditions: Major Depressive Disorder

Summary: depression affects approximately 2.5% of children and 8% of adolescents. escitalopram is the s-enantiomer of citalopram. both escitalopram and citalopram are selective serotonin reuptake inhibitors (ssris) and are used to treat depression in adults. this study is designed to provide a systematic evaluation of the safety and efficacy of escitalopram in the treatment of depressed pediatric patients, 12 to 17 years of age. patients completing the study will be eligible to enter an open-label extension study.


Eligibility criteria:
inclusion criteria: * patient must meet diagnostic and statistical manual, fourth edition (dsm-iv) diagnostic criteria for major depressive disorder. * patient's current depressive episode must be at least 12 weeks in duration * patient must have a parent or caregiver who must agree to accompany the patient to all clinic visits. exclusion criteria: * patients who currently meet dsm-iv criteria for: 1. attention deficit-hyperactivity disorder 2. obsessive-compulsive disorder 3. posttraumatic stress disorder 4. bipolar disorder 5. pervasive developmental disorder 6. mental retardation 7. conduct disorder 8. oppositional defiant disorder * patients who are considered a suicide risk (have active suicidal ideation), who have made a suicide attempt, or who have ever been hospitalized because of a suicide attempt.

Keywords: major depressive disorder depression adolescents escitalopram pediatrics
the efficacy of huaiqihuang granule in children with primary nephrotic syndrome

Conditions: Nephrotic Syndrome

Summary: this is a multisite, open-label, prospective and registered study designed to evaluate the efficacy and safety of huai-qi-huang granule in children with primary nephrotic syndrome.

this is a multisite, open-label, prospective and registered study designed to evaluate the efficacy and safety of huai-qi-huang granule in children with primary nephrotic syndrome(pns). the study will be planned at 1500 participants, and subjects will be on study for up to one year. data will be collected by authorized physicians for 48 weeks. all of the data included demographic characteristics, information about pns, laboratory tests and adverse events.

Eligibility criteria:
inclusion criteria: 1. in accordance with pediatric branch , the chinese medical association in 2009: guidelines for diagnosis and treatment of common kidney diseases in children (for trial)ⅰ. hormone-sensitive, relapsed/dependent nephrotic syndrome diagnostic and evidence-based guidelines; ⅲ.diagnostic criteria for the diagnostic and evidence-based guidelines for hormone-resistant nephrotic syndrome, which means children who are diagnosed with primary nephrotic syndrome should be included; 2. age from 1 to18; 3. alt and ast levels do not exceed twice the upper limit of the normal range;; 4. provision of written informed consent by legal guardians. exclusion criteria: 1. a variety of secondary nephrotic syndromes are caused by infectious diseases such as lupus nephritis, hepatitis b associated nephritis, purpura nephritis, and eb virus, cytomegalovirus (cmv), etc; 2. with combined diseases of cardiovascular, liver, hematopoietic system, mental disorders and other serious diseases; 3. history of diabetes or examinations showed elevated blood glucose levels; 4. participation in other ongoing clinical trials or during their observation period within the last three months prior to visit 1; 5. previous/concomitant treatment with any other immunomodulators within the last three months prior to visit 1 ; 6. patients who are unlikely to adhere to the protocol.

Keywords: huaiqihuang granule primary nephrotic syndrome multisite prospective open-label
examining the effect of metaverse-based epilepsy education

Conditions: Examining the Effect of Metaverse-based Epilepsy Education on Parents' Knowledge Level

Summary: the research is a randomized controlled experimental study and was planned to examine the effect of metaverse-based epilepsy education on the epilepsy knowledge level of parents.

developments in the field of technology, patient density in polyclinic services, limited number of nurses specialized in the field and the desire to carry out effective workforce planning bring different education methods to the agenda in the field of nursing. creating the metaverse universe, which has been used in many technological fields in recent years, is among the newest of these technological developments. when the content created in metaverse-based training is presented to the user, the user has the opportunity to enter the universe, choose the avatar the participant wants, and navigate and gain information by entering the desired module among the training modules created for participant. at the same time, since it offers an interactive training module to the participant, there are no limitations such as time, place or subject as in other training models. when the literature was examined, no study was found in which metaverse-based education was used in the field of epilepsy. in this context, our research aimed to examine the usability of metaverse-based epilepsy education and its effect on parents' epilepsy knowledge level.

Eligibility criteria:
inclusion criteria: * must be able to use a smartphone with internet access * having a child diagnosed with epilepsy exclusion criteria: * having an additional chronic disease (diabetes, chronic kidney failure, cancer, etc.) other than epilepsy

Keywords: epilepsy metaverse parent knowledge level
control and burden of asthma and rhinitis

Conditions: Asthma; Rhinitis

Summary: an observational cross-sectional study will include 750 individuals of all ages, divided in 4 groups: 1) patients with a self-reported diagnosis of asthma alone (n=150), 2) patients with a self-reported diagnosis of rhinitis alone (n=150), 3) patients with a self-reported diagnosis of asthma and rhinitis (n=150) and 4) patients with no history of respiratory symptoms or diseases (n=300)

during 2010, we've conducted two cross-sectional, telephonic national surveys that assessed the prevalence (portuguese asthma prevalence survey - paps) and the control (portuguese asthma control survey - pacs) of asthma and rhinitis. before these surveys there was no country-wide data on prevalence or about the control of asthma in portugal.we propose an additional study that will apply a comprehensive set of diagnostic tests and clinical assessment to a sub-sample of participants in the pacs study. the effect of asthma, rhinitis and their control on personal and social burden will be studied comparing patients with current asthma and/or rhinitis and individuals with no respiratory symptoms.sample size calculations were based on the comparison of quality of life measured by whoqol-bref in patients with different diagnosis. data collection includes anthropometric measurements, lung function \& inflammation tests, allergy tests, a structured clinical interview and standardized questionnaires. research assistants performing the evaluations will be blinded to the subject classification in paps and pacs and to the results of the questionnaires administered, namely the ga2len survey instrument and carat. the data collection will be organized with the local public health delegate and will take place as close as possible to the participants' communities at a local health unit or in the surrounding area, in order to minimize dropouts.

Eligibility criteria:
inclusion criteria: all subjects that were included in pacs and that have expressed their willingness to participate in a clinical assessment of asthma. new participants that have medical diagnosis of asthma, rhinitis, or are healthy. exclusion criteria: persons who don't understand spoken portuguese. persons who have cognitive or physical conditions thta could hamper their participation in the study.

Keywords: asthma rhinitis control burden
remote access to care, everywhere, for parkinson disease

Conditions: Parkinson Disease

Summary: the primary objective of this study is to evaluate the feasibility, efficacy and the value of providing care to individuals with parkinson disease directly into their homes. the specific aims are: 1. to demonstrate the feasibility of conducting remote evaluations of patients with parkinson disease nationally; 2. to measure the impact of remote care on each patient's ability to improve his or her quality of life (qol) and better manage his or her parkinson disease; and 3. to assess the long-term acceptability to patients in receiving ongoing care remotely via telemedicine.


Eligibility criteria:
inclusion criteria: * age greater than 30 * self reported diagnosis of idiopathic parkinson disease * ability to converse in english * ability and willingness to provide informed consent and complete study requirements * access to a non-public computer or similar devices with broadband internet. * located in new york, maryland, delaware, california, or florida at time of virtual visit (or veterans with parkinson disease anywhere in the u.s.) exclusion criteria: * any condition (e.g.prominent psychosis) that in the investigator's or coordinator's judgment would preclude participation. * concurrent enrollment in another telemedicine study.

Keywords: telemedicine virtual care visit remote visit video-conferencing
acceptance-based behavioral treatment for obesity: maintenance and mechanisms

Conditions: Acceptance-based Treatment; Standard Behavioral Treatment

Summary: the primary goal of this project is to determine if an innovative behavioral weight loss program that incorporates new developments from the field of behavior therapy produces superior weight control than standard behavioral treatment. a sample of 200 adults from the community are participating in this study.


Eligibility criteria:
inclusion criteria: * be between the ages of 18 and 70 * have a bmi between 27-50 * have the ability to engage in physical activity (i.e., can walk at least 2 blocks without stopping for rest). * agree to provide permission for the research team to regularly contact your physician throughout the study to share information on changes in your weight. * successfully complete all steps in the enrollment process exclusion criteria: * you have a medical condition or psychiatric condition that may limit your ability to comply with the behavioral recommendations of the program or pose a risk to you during weight loss. * you are pregnant or plan to become pregnant in the next three years. * report recently beginning a course of or changing the dosage of prescription medications that can cause significant weight loss or weight gain. * you are participating in or plan to participate in another weight loss program in the next three years. * the research team identifies any factors that would render you potentially unable or unlikely to follow the protocol, or unable to benefit from it.
survey among healthcare professionals treating patients with metastatic breast cancer in selected european countries to evaluate their knowledge on management of hyperglycemia when using alpelisib

Conditions: Breast Cancer

Summary: this was a multinational, non-interventional, cross-sectional survey conducted among hcps based in the eu/eea who prescribe piqray. the survey assessed the knowledge of hcps prescribing piqray in relation to the management of hyperglycemia in patients treated with piqray.


Eligibility criteria:
inclusion criteria: * had prescribed piqray to at least 1 locally advanced or mbc patient within 6 months prior to completing the survey. * provided permission to share their anonymized responses in aggregate with ema or ncas, if requested. exclusion criteria: hcps who are direct employees of novartis, the ema (or any other regulatory bodies), or icon.

Keywords: educational material pass
study to evaluate anxiety sensitivity and somatic symptoms as risk factors for ponv

Conditions: Postoperative Nausea and Vomiting

Summary: this prospective observational study aims to evaluate the influence of somatic symptom load and anxiety sensitivity as risk factors for the occurrence of postoperative nausea and vomiting (ponv). physiological and psychological variables are assessed in female patients with an increased risk for ponv prior to a planned surgical intervention with a 33-item questionnaire composed of the asi-3 and the phq-15. postoperative evaluation includes the occurrence of nausea and vomiting in the first 24 hours after surgery. it is hypothesized that patients with high sum scores for somatic symptom load (measured with the patient health questionnaire, phq-15) and with increased levels for anxiety sensitivity (measured with the anxiety sensitivity index, asi-3) experience more frequently postoperative nausea and vomiting (ponv) than patients with low scores in both self-rating instruments.


Eligibility criteria:
inclusion criteria: * female patients 18-75 years * non-smokers * must be able to give written informed consent * planned surgical intervention requiring hospitalisation * not included in another clinical trial exclusion criteria: * emergency intervention * total intravenous anesthesia (tiva) with propofol * disability to give written informed consent * physical or psychic disorders requiring permanent psycho-social care * no german language skills

Keywords: anxiety somatoform disorders
evaluation of a daily brief exercise intervention on resident physician personal resiliency and burnout

Conditions: Burnout, Professional; Burnout Syndrome

Summary: this study seeks to evaluate the prevalence and characterize predictors of physician burnout in the anesthesia residency at vanderbilt university medical center. the study also seeks to evaluate the effect of an exercise intervention on burnout and personal resiliency (i.e., less individual stress given the same workload).

a cross-sectional evaluation of burnout, perceived stress, average sleep propensity, and social support and coping mechanisms will be assessed from four years of vanderbilt university medical center (vumc) anesthesia residents. burnout will be assessed using the maslach burnout inventory (mbi-hss). participating interns, anesthesia residency class 1 (ca-1), and anesthesia residency class 2 (ca-2) classes will be randomized to 8 weeks of an exercise intervention (15 min of activity at 70% of max heart rate or higher, 5 days a week) to meet the activity recommendations of the office of disease prevention and health promotion or 8 weeks of continuing their baseline activity level prior to the study.

Eligibility criteria:
inclusion criteria: * vanderbilt university medical center anesthesiology residents (class 1(ca-1), class 2 (ca-2) exclusion criteria: * failure to sign informed consent * will not be in town and available for the full duration of the study (e.g., 2 or more weeks of vacation or absence) * physical inability to perform the exercise intervention (including health indications)
post operative cognitive dysfunction after breast surgery

Conditions: Emergence Delirium; Post-Operative Cognitive Dysfunction

Summary: aim of this trial is to define if post-operative cognitive dysfunction, detected analyzing changes between pre-operative and post-operative neurocognitive test, and postoperative delirium, relate to concentration of effector's site concentration of propofol and remifentanil tci and to the common intraoperative neuromonitoring values as well as to pupillometry values (in particular pupil diameter, pupil latency, and maximum contraction velcoity).

post-operative cognitive dysfunction has not been yet investigated after general anaesthesia with targeted-controlled-infusion (tci) and laryngeal-mask-airway (lma), daily used in the investigator's hospital to anesthetize women undergoing breast surgery. aim of this trial is to define if neurocognitive tests (montreal cognitive assessment, trail making test a and b, digit span test) before and after surgery, and cam for postoperative delirium relate to concentrations at effector's site (ce) of propofol and remifentanil tci and the values of bispectral index and entropy monitoring and surgical plethysmographic index (spi), as well as to pupillometry values.

Eligibility criteria:
inclusion criteria: * general anaesthesia delivered with propofol and remifentanil with targeted controlled infusion * use of laryngeal mask airway exclusion criteria: * neurological pathologies * haemodynamical instability during surgery

Keywords: infusion pumps intraoperative brain monitoring
cypass clinical experience study

Conditions: Open Angle Glaucoma (OAG)

Summary: this study is to evaluate the long-term safety, effectiveness and clinical experience of the cypass micro-stent in patients with glaucoma.


Eligibility criteria:
inclusion criteria: * diagnosis of oag * iop ≥ 21 mmhg and ≤ 31 mmhg (with or without ocular hypotensive medication) exclusion criteria: * acute angle closure, narrow angle, uveitic or neovascular glaucoma * normal tension glaucoma

Keywords: glaucoma glaucoma device glaucoma surgery intraocular pressure
intra-articular pulsed radiofrequency in chronic knee pain

Conditions: Osteoarthritis, Knee; Osteoarthritis; Pain, Chronic

Summary: the aim of this study is to investigate the additional effect of intra-articular pulsed radiofrequency (iaprf) on pain and functional activities in addition to intra-articular steroids in patients with grade ii and iii knee osteoarthritis.

this randomized controlled trial included patients over 18 years of age with knee pain persisting for more than 3 months and stage ii-iii knee oa according to the kellgren-lawrence scale. the participants were randomized into two groups: the iaprf + steroid injection (group 1) and only steroid injection (group 2) groups. the injections were administered under fluoroscopic guidance in both groups, and the needle was advanced to the midline of the tibiofemoral joint in the anteroposterior and lateral views. group 1 received 8 mg of intra-articular dexamethasone after iaprf application for 360 s at 45 v voltage, with the temperature not exceeding 42°c. group 2 received 8 mg of intra-articular dexamethasone only. pain intensity and participation in daily activities were evaluated using the numerical rating scale (nrs) and western ontario and mcmaster universities arthritis index (womac), respectively, before the procedure and 1, 4, and 12 weeks after the procedure.

Eligibility criteria:
inclusion criteria: * age \> 18 years, * having knee pain persisting for more than 3 months due to knee osteoarthritis (oa), * kellgren-lawrence classification grades ii and iii oa, * giving written and verbal informed consents. exclusion criteria: * patients with a history of undergoing knee surgery and/or receiving any intra-articular knee injection within the previous 6 months, * having a local or systemic infection or a coagulation disorder, * patients who refused to participate in the study.

Keywords: intra-articular pulsed radiofrequency knee osteoarthritis intra-articular steroid injection
boost - benefit of frequent optimization after cardiac resynchronization therapy device replacement

Conditions: Heart Failure

Summary: cardiac resynchronization therapy (crt) has shown improvement in mortality and morbidity in patients with left ventricular systolic dysfunction and congestive heart failure. additionally in crt patients it has been demonstrated that optimizing paced/sensed atrioventricular (av) and interventricular (v-v) timings leads to immediate hemodynamic benefits and further improves cardiac function. recent studies have shown that optimal paced/sensed av and v-v delays change over time, which raises the question of how often optimization should be repeated. thus, frequent re-optimization of these delays might be beneficial for maintaining significant improvement of cardiac function. however, it remains to be evaluated whether timing optimization may be beneficial on patients who have received crt for a number of years and are now having the crt device replaced.

* this is a prospective, randomized, and multicenter study * patients who have received a replacement st. jude medical(sjm) crt device, either crt-p or crt-d, within the last two weeks post crt replacement will be considered for enrollment in the study. * baseline measurements will be performed at the time of enrollment. * patients are followed up to 12 months post crt replacement with data collected at 3, 6, 9 and 12 months post crt replacement. * patients will be randomized at enrollment to either group 1 (use of sjm algorithm to optimize programming) or group 2 ("control").

Eligibility criteria:
inclusion criteria: * patient underwent a crt replacement within the last two weeks, triggered by either the elective replacement indicator (eri)/end of life (eol), or by receiving a crt-d device as an upgrade from a crt-p device. * patient has received an fda approved sjm crt device as a replacement to the old crt device within the last two weeks. * patient has the ability to complete a 6-minute hall walk without any assistance. * patient is willing to provide written informed consent. * patient has the ability to independently comprehend and complete a qol questionnaire. * patient is geographically stable and is willing to comply with the required follow-up schedule. exclusion criteria: * patient had paced/sensed av and/or v-v delay optimization using quickopt before crt replacement. * patient had any paced/sensed av and/or v-v delay optimization within 3 months before crt replacement. * patient has an ability to walk ≥ 450 meters (≥ 1476 feet) in 6 minutes. * adequate patient's echocardiography/doppler images will not be available. * patient is expected to receive a heart transplant during the duration of the study. * patient has an epicardial ventricular lead system (active or inactive). * patient has limited intrinsic atrial activity (≤ 40 bpm). * patient has persistent or permanent atrial fibrillation (af). * patient has 2° or 3° heart block. * patient's life expectancy is less than 1 year. * patient is less than 18 years old. * patient is pregnant. * patient is on iv inotropic agents 1 month prior to crt replacement.