Kornimate/medical-research-clean huggingface dataset:
mohs and immunofluorescence for malignant melanoma in situ

Conditions: Lentigo Maligna; Melanoma In Situ

Summary: the purpose of this study is to determine if immunofluorescence (if) can effectively identify features of malignant melanoma in situ, on sun-damaged skin, in the setting of mohs micrographic surgery.

the aim of this study is to 1. determine the feasibility of using melanocytic markers such as melanoma antigen recognized by t cells 1 (mart-1) with fluorescence to clear surgical margins when compared to conventional mart-1 immunohistochemistry (ihc) in the setting of mms for lm (lentigo maligna type melanoma in situ). 2. compare the use of a cocktail of immunofluorescent markers such as, but not limited to, sex-determining region y (sry)-box 10 (sox10), human melanoma black 45 (hmb-45), and kiel-67 (ki-67) to sections only stained with fluorescent mart-1 alone. 3. explore the value of using other combinations of immunofluorescent markers such as s-100 with microphthalmia-associated transcription factor (mitf), nestin with ki-67, and hmb-45 with lamin.

Eligibility criteria:
inclusion criteria: 1. male or female of any race and at least 18 years of age 2. patient with biopsied proven lentigo maligna (lm) in situ 3. patient meets criteria for mohs micrographic surgery (mms) 1. the cancer is large 2. the edges of the cancer (clinical margins) cannot be clearly defined 3. prior treatment has failed, i.e. recurrent tumor 4. the cancer is located in a cosmetically sensitive or functionally critical area of the body (such as eyelids, nose, ears, lips, fingers, toes, and genitals) 5. the histologic pattern of the cancer is aggressive 6. the patient is immunosuppressed 4. patient with biopsied proven lm in situ located on an anatomic areas appropriate for mms: 1. area h: ''mask areas'' of face (central face, eyelids \[including inner/outer canthi\], eyebrows, nose, lips \[cutaneous/mucosal/vermillion\], chin, ear and periauricular skin/sulci, temple), genitalia (including perineal and perianal), hands, feet, nail units, ankles, and nipples/areola. 2. area m: cheeks, forehead, scalp, neck, jawline, pretibial surface. 3. area l: trunk and extremities (excluding pretibial surface, hands, feet, nail units, and ankles). 5. patient able to tolerate surgery 6. patient is able to comply with appointments including follow-up appointments 7. ability to understand and willingness to sign a written informed consent document exclusion criteria: 1. patients under the age of 18 2. patient does not meet criteria for mms or has lm located in areas that are not accessible with mms 3. patient with previously diagnosed invasive lm 4. patients unable to comply with follow-up 5. adults unable to consent 6. pregnant women 7. prisoners

Keywords: melanoma in situ lentigo maligna confocal microscopy direct immunofluorescence
effect of ciprofloxacin versus levofloxacin on qtc-interval and dysglycemia

Conditions: QTc Prolongation, Hyperglycemia, Hypoglycemia

Summary: to compare intravenous levofloxacin and ciprofloxacin regarding their risk on the corrected qt interval (qtc) prolongation and dysglycemia in diabetic and non-diabetic patients.

fluoroquinolones represent an important class of antibacterial drug and they are used worldwide.fluoroquinolones are classified into generations according to the spectrum of antimicrobial activities that targeted them.fluoroquinolones may cause several side effects as tendon rupture, central nervous toxicity, cardiovascular toxicity, gastrointestinal toxicity, phototoxicity, disrupted glucose metabolism, skin disorders and hypersensitivity. ciprofloxacin, a second generation fluoroquinolone, is one of the most successful and widely used compounds of fluoroquinolone. on the other hand, levofloxacin is a third generation fluoroquinolone. diabetes mellitus (dm) is chronic disease and a serious of metabolic disorder associated with the presence of hyperglycemia due to partial or complete insulin deficiency. diabetes mellitus is a major risk factor for cardiovascular diseases. fluoroquinolone class is associated with cardiac side effects as qtc prolongation. some agents of fluoroquinolones were withdrawn from market. however, cardiac adverse effects has been developed with fluoroquinolones still in market. members of fluoroquinolones class have different effects on qt interval. the us fda suggested that the risk and benefits ratio of fluoroquinolones should be taken into consideration. in addition to hyperglycemia events are more common with fluoroquinolones than with other classes of antibiotics. the food and drug administration (fda) confirmed the current warning that fluoroquinolones may cause decrease in blood sugar especially in diabetic patients. however, other study proved that fluoroquinolones may cause dysglycemic events in diabetic and non-diabetic patients.

Eligibility criteria:
inclusion criteria: * adult patient (male, female) * age from 18 to 70 years . * be able to give an informed consent form after understanding for reasonable explanation of clinical trial's purpose, contents and characteristics of clinical drugs * wiling to participate whole clinical trial periods exclusion criteria: * younger than 18 years or older than 70 years. * has prolonged qtc before receiving therapy. * with a history of heart diseases. * received class ia or iii antiarrhythmic agents. * received macrolide antibiotics. * with a history of quinolone allergy. * pregnant and lactating women.

Keywords: levofloxacin, ciprofloxacin, qtc prolongation, dysglycemia.
efficacy of copper in reducing health-acquired infections in a pediatric intensive care unit

Conditions: Nosocomial Infections

Summary: healthcare-acquired infections (hai) cause substantial patient morbidity and mortality. commonly touched items in the patient care environment harbor microorganisms that may contribute to hai risk. the purpose of this study is to assess whether placement of copper-alloy surfaced objects in a pediatric intensive care unit (picu) reduce risk of hai in comparison with non-copper surfaced objects.


Eligibility criteria:
inclusion criteria: * patient admitted to picu * stay at picu \> 24 hours * informed consent by parent/legal representative exclusion criteria: none

Keywords: copper health-acquired infections bacterial load intensive care units, pediatric
lumbosacral muscle sensitivity & pressure pain threshold after kettlebell swings

Conditions: Muscle Soreness; Muscle Weakness; Muscle Tenderness

Summary: the primary purpose of the study is to assess the muscle contractility and sensitivity of lumbar erector spinae, biceps femoris, and gluteus maximus short-term response to tabata kettlebell swing protocol.

while there are many studies that combine resistance exercise with tmg, there are no studies that combine tmg or pressure algometry with an isometric hold of a kettlebell. this will be the first study that will observe the relationship between these specific variable it has also been noted that kettlebell swings have an acute effect on muscle sensitivity. a study conducted by hanney et al. (2017) demonstrated that there was an increase in the mean lumbosacral muscle pain pressure threshold across three locations measured. research by hanney et al. is also the only article that has combined kettlebell swings and pressure algometry. as mentioned earlier, these researchers measured the effects of kettlebell swings on pressure pain threshold in the quadratus lumborum, paravertebral muscles, and the piriformis after an acute bout of 2 handed kettle-bell swings. compared to a control group, the kettlebell swing group had significantly higher pressure pain thresholds for all three of the testing sites. researchers believe this may be due to an increased hyperemia-state post exercise, where the increased blood flow and vasodilation flushes out muscle metabolites. clearing of these metabolites which normally activate chemo-nociceptive free nerve endings, are theorized to decrease pain sensitivity. this post-exercise hyperemia, leading to decreased pressure pain thresholds, may be directly related to the changes in contractility of the muscle after resistive exercise.

Eligibility criteria:
inclusion criteria: * participant is a male or female between the ages of 18 and 35 years old * participant is asymptomatic for low back pain exclusion criteria: * participant is unable to participate in physical activity, as determined by the par-q+ * have any injuries or other chronic pain that would prevent them from performing a high intensity kettlebell swing protocol

Keywords: tensiomyography pressure algometry kettlebell swings muscle sensitivity
biochemical role of circulating micrornas expression as diagnostic markers for non-hodgkin's lymphoma patients

Conditions: Non-Hodgkin Lymphoma

Summary: lymphomas are a fairly common malignancy accounting for approximately half of all newly diagnosed hematological neoplasms, and they comprise the sixth most common group of malignancies worldwide in both men and women, with marked geographic variations and affecting more males than females within the age range of 1 to 85 years but peaking within the second decades of life (oluwasola ao et al., 2011, roman e et al., 2011 and jemal a et al., 2010) . lymphomas have traditionally been classified as either hodgkin's lymphoma (hl) or non-hodgkin's lymphoma (nhl) based on the presence or absence of the reed-sternberg (rs) cell on histology. (fitzmaurice c et al., 2017). non-hodgkin's lymphoma (nhls) comprise a wide class of lymphoid neoplasms that evolve from the clonal expansion of mature b, t and natural killer (nk) cells in different stages of development (morton, l.m. et al., 2014 and schmitz r et al., 2009). nhls are the most prevalent hematopoietic neoplasms, accounting for approximately 4.3% of all cancer diagnoses (sant, m. et al., 2010) , of them, b cell nhl accounts for approximately 30% of all lymphoid neoplasms, followed by hl (8%) and t/nk neoplasms (5%) (morton, l.m. et al., 2006). micrornas (mirnas) are a class of small, naturally occurring, noncoding and single-stranded rna molecules (18, 22 nucleotides) that function as post-transcriptional regulators by directly cleaving target messenger rna (mrna) or translational repression (bartel dp. et al., 2004). the discovery of mirna has exposed a new layer of gene expression regulation that affects many physiological and pathological processes of life (lawrie ch. et al., 2013). many abnormal mirna expression patterns are found in various human malignancies, and certain mirnas play roles as oncogenes or tumor suppressors (ling n et al., 2013). certain mirnas have been found to characterize various subtypes of nhl and have important roles in b-cell differentiation and lymphomagenesis (zhang j et al., 2009, malumbres r et al., 2009, basso k et al., 2009 and auer rl et al., 2011). recently, many studies had shown that tumor cell-specific mirnas were detectable in the plasma and serum of patients with cancer. therefore, mirnas may be served as good biomarkers for early detection, diagnosis, and follow up of patients with cancer (cortez ma et al., 2012).


Eligibility criteria:
inclusion criteria: 1. this study will include patients who have newly diagnosed, histo-pathologically proved non-hodgkin's lymphoma. 2. age from 18 to 75 years old. 3. anti-neoplastic treatment naïve patients. 4. no associated other malignancies (neither synchronous nor metachronous) than non-hodgkin's lymphoma. exclusion criteria: 1. children below 18 years old or elderly people more than 75 years old 2. patients not newly diagnosed with non-hodgkin's lymphoma 3. presence of any associated other malignancies than non-hodgkin's lymphoma
laser assisted icsi; has it role whatsoever?

Conditions: Laser Assistance to Improve ICSI Outcome

Summary: laser-assisted icsi (la-icsi) was described to be a new method combining a less invasive icsi technique with assisted hatching.this procedure is usually used for mii oocytes possessing oolemma breakage difficulties, but why not using it for even normal oocytes?!. especially because data indicated that in addition to an improved oocyte survival, this new approach increases the hatching rate in vitro. but since it is still debatable that such a small opening might impair the hatching process, so modified zona thinning technique was proposed for more embryo safety.

this study aims to compare the la- icsi by drilling a micro hole (lad-icsi) and modified la-icsi by zona pellucida thinning (lat-icsi) with conventional icsi in order to effectively assess whether this approach can be applied routinely to improve icsi outcome. one arm study divided into three interventions; conventional icsi (control group) was compared with lad-icsi (study group 1) and lat- icsi (study group 2) in sibling oocytes. the rates of maturation, fertilization, devision, blastulation and good quality blastulation rates were assessed in the three groups cases were randomly selected for embryo transfer from the three groups,then chemical pregnancy and clinical pregnancy rates were compared between the three groups.

Eligibility criteria:
inclusion criteria: * patients aged from 20 years old to 37 years old * good res-ponders * gives more than 15 oocytes * endometrial thickness more than 9 mm exclusion criteria: * poor res-ponders * severe oligoasthinozoospermia of male partners * testicular samples * poor quality oocytes

Keywords: laser assisted-icsi zona pellucida thinning icsi embryo good quality rate hatching rate
the role of intestinal microbiota dysbiosis in the development of spondyloarthritis

Conditions: Spondyloarthritis; Ruminococcus Gnavus

Summary: the primary objective of this case-control study aims to explore the role of bacterium ruminococcus gnavus (r. gnavus) with intestinal biopsy and faecal sampling in the initiation and the development of spondyloarthritis (spa) in comparison with health control subjets (patients without chronic disease but have indication to digestive endoscopy).

as secondary objectives, the study aims: * to research the abundance of bacterial strain of r. gnavus in mucosal sampling by biopsy; * to study the interaction between r. gnavus bacterium and mucus from histological sampling; * to correlate the expression of genes of intestinal mucus with the variations of identified microbiota of mucus biopsy; * to study the interaction between bacteria and intestinal epithelial cells during culture; * to demonstrate perturbations of the immune responses by dysbiosis.

Eligibility criteria:
inclusion criteria: patients with spa: * patients ⩾ 18 years; * diagnosed as spondyloarthritis (spa) according asas classification; * affiliated to a social security scheme; * have signed the written informed consent form. control subjects: * subjects ⩾ 18 years; * subjects free of spa and planned for a digestive endoscopy for another indication such as to explore the risk of colorectal cancer in family member; * affiliated to a social security scheme; * have signed the written informed consent form. exclusion criteria: * subjects unable to understand the proposed study and/or sign a informed consent form; * pregnant women or breast feeding women; * subjects under guardianship or curatorship; * have taken antibiotic 1 month prior to inclusion; * presenting acute or chronic severe pathology may likely to interfere with the interpret of outcome; * refusal of subjects to participate to the study; * foreign patients under french ame scheme.

Keywords: spondyloarthritis ruminococcus gnavus microbiota dysbiosis
investigation of dual-task exercise's effect in parkinson's disease

Conditions: Parkinson Disease

Summary: this study was conducted to investigate the effects of dual-task training on upper extremity motor functions in patients with parkinson's disease. a total of 32 patients participated in the study. patients were divided into two groups by randomization. one group received only conventional physiotherapy applications, while the other group performed dual-task exercises in addition. dual-task exercises were performed while conventional treatment was applied. the treatment program was applied as 60x5x6 min/day/week. conventional treatment was determined according to the individual needs of the patients, including the lower and upper extremities. dual-task interventions included performing such as counting backward, word recall, and reading words backward. assessments were repeated twice: baseline and after a 30-session. "demographic information", "movement disorder society (mds)-unified parkinson's disease rating scale (mds-updrs)", "box and block test" and "parkinson disease questionnaire (pdq-39) were used as assessment tools.


Eligibility criteria:
inclusion criteria: * patients aged 50-85 years with a diagnosis of stage 1-3 parkinson's disease, based on the hoehn \& yahr scale * patients had to have no issues with performing basic mathematical operations, - a mini-mental state examination (mmse) score above 24 points, * regular medication use for at least 4 weeks (for patients who were prescribed medical treatment), * no comorbid neurological, neuromuscular, or orthopedic diseases exclusion criteria: * patients with vision or hearing impairments, * moderate-to-severe fluctuations in tremor or dyskinesia, * having deep brain stimulator implants, or sensory loss in the upper extremities.
fascia iliaca blocks for pain control after total hip arthroplasty

Conditions: Arthritis of Hip

Summary: the fascia iliaca compartment block (ficb) is a regional block that anesthetizes the femoral, obturator, and lateral femoral cutaneous nerves around the hip. the purpose of this study is to determine whether ficb can reduce postoperative pain and increase progress with physical therapy after total hip arthroplasty (tha). this randomized, double-blind, clinical trial will randomize patients to receive either a ficb or placebo after tha. the primary outcomes will be pain scores reported by the patient post-operatively.

the ficb is a regional block that anesthetizes the femoral, obturator, and lateral femoral cutaneous nerves around the hip joint. there have been numerous study assessing it's ability to control pain in the pre and post operative period in patients with hip fractures. however, there is a limited amount of literature on its efficacy after total hip arthroplasty, and no data when a posterior surgical approach to the hip was utilized. because regional blocks have been shown to decrease pain post operatively after total knee arthroplasty, we hypothesize that the ficb will decrease pain and narcotic use in patients after total hip arthroplasty. this study will aim to recruit 120 patients that will be randomized to receive a ficb or placebo in the recovery room within 30 minutes of leaving the or. once the intervention is complete we will collect data on the patients' pain levels, morphine equivalents of narcotic that they used, and how well they worked with physical therapy during their inpatient stay.

Eligibility criteria:
inclusion criteria: * patients over the age of 18 * scheduled for total hip arthroplasty at henry ford hospital * epidural anesthesia during surgery exclusion criteria: * pregnancy * known intolerance to local anesthetic or narcotics * revision hip surgery

Keywords: total hip arthroplasty fascia iliaca nerve block pain control
norwegian birch rust allergy study

Conditions: Hypersensitivity, Immediate

Summary: this study investigates whether spores from birch rust fungi (melampsoridium betulinum = mb) may be the eliciting allergen in patients with seasonal airway allergy during autumn in north norway. patients with suspected allergy to mb are compared with non-allergic controls using data about allergic disease and daily allergic symptoms during autumn. potential variations in allergic symptoms during season will be compared with spread of mb spores. sensitation to mb and mb allergy are to be tested with skin prick test (spt), measurements of spesific immunglobulin e (ige) in serum, passive basophil activation test (pbat) and nasal provocation test (npt)

symptoms of seasonal airway allergy most commonly take place during spring and summertime, normally attributed to pollen from birch or grass. however, some patients in the clinic have experienced and reported typical airway allergy symptoms during autumn, when there is no spread of pollen. the patients report symptoms of allergic rhino-conjunctivitis and/or asthma, and some also tells about worsening in eczema/skin affections. birch rust is a disease on birch trees caused by the fungus melampsoridium betulinum (mb), and apparently mb spreads in largest amounts in august and september - especially in north norway. this study aims to investigate if mb is an allergen causing seasonal airway allergy during autumn in norway. both type and severity of symptoms of mb allergy are to be investigated, and also the association between spread of mb spores and symptoms of airway allergy. during the study period there are to be developed mb extracts for skin prick test (spt), serum specific ige (sige), nasal provocation test (npt) and passive basophil activation test (bat), and sensitivity and specificity of spt, sige and bat will be calculated in comparison to npt as a gold standard test for allergic rhinitis caused by mb.

Eligibility criteria:
inclusion criteria: * self-reported symptoms of allergic rhinitis, conjunctivitis, allergic asthma and/or exacerbation of eczema in the period from august to october. exclusion criteria: * perennial airway allergy without worsening of symptoms during autumn. * too long or inadequate distance from home to hospital/testcenter. * more than 14 days of absence from northern norway during symptomregistration autumn 2022 (august 15 - september 30, 2022). * diseases with persistent manifestations that can interfere or be confused with airway allergic symptoms. * treatment with immunosuppressive drugs.

Keywords: birch rust fungi melampsoridium betulinum allergy allergic rhino-conjunctivitis allergic asthma eczema
18f-naf-pet for identification of tcfa

Conditions: Acute Coronary Syndrome

Summary: recently, positron emission tomography(pet) using 18f-sodium fluoride (naf) showed promising results for detecting vulnerable plaques in some pilot studies. in this study, the investigators will evaluate the diagnostic accuracy of 18f-naf pet for non-invasively detecting vulnerable plaque, diagnosed by optical coherence tomography (oct).

it has been well known that mechanism of acute coronary syndrome is plaque rupture and occlusion of coronary artery by this plaque rupture. until now, evaluation of vulnerable plaque have been mainly performed with invasive imaging modalities such as optical coherence tomography or intravascular ultrasound. recently, positron emission tomography(pet) using 18f-sodium fluoride (naf) showed promising results for detecting vulnerable plaques in some pilot studies. in this study, we will evaluate the diagnostic accuracy of 18f-naf pet for non-invasively detecting vulnerable plaque, diagnosed by optical coherence tomography (oct).

Eligibility criteria:
inclusion criteria: * 1. patients with angina pectoris who are scheduled to do invasive coronary angiography. * 2. patients who have moderate (40-70%) stenosis at proximal or mid-portion of major coronary arteries. confirmed by coronary ct angiography. * 3. patients who are anticipated coronary artery disease.(probability \> 90 %) * 4. acute coronary syndrome. exclusion criteria: * 1. stenosis at distal coronary or small vessel. * 2. patients who don't have moderate (40-70%) stenosis at proximal or mid-portion of major coronary arteries. confirmed by invasive coronary angiography. * 3. inadequate quality of 18f-naf pet-ct * 4. inadequate quality of optical coherence tomography (oct), ivus, coronary ct angiography

Keywords: positron emission tomography tissue background ratio optical coherence tomography thin cap fibroous atheroma vulnerability acute coronary syndrome