Kornimate/medical-research-clean huggingface dataset:
the use of biologic mesh vs bioabsorbable mesh during ventral hernia repair in at-risk patients

Conditions: Ventral Hernia

Summary: this study evaluates the outcomes of patients who have been treated with strattice or gore bio-a mesh for the repair of complicated abdominal wall hernias. the purpose of this study is to collect information and evaluate the outcome of your surgery. synthetic (man made) mesh has been shown to provide durable long-term outcomes; however, this type of mesh should not be used in patients at risk of developing an infection. therefore, to address the challenge of finding an artificial strengthening material to repair complicated hernias in patients that could potentially develop surgical infection, two types of non-permanent materials have been developed, including biologics and bioabsorbables. biologic mesh is made of living tissue and bioabsorbable mesh is made of synthetic material that is gradually absorbed by the body over time. the purpose of this study is to allow surgeons to compare the postoperative course of patients associated with these two mesh types to decide which material will improve the outcomes of their patients with complicated abdominal wall defects. to date there is no evidence to suggest that either mesh type is superior or safer than the other.

the goal of the proposed study is to evaluate the outcomes of patients implanted with strattice® (lifecell corporation, branchburg, nj, usa) and gore® bio-a® (w. l. gore \& associates, inc., newark, de, usa) for the repair of abdominal wall defects in at-risk patients. primary endpoints of the study will include hernia recurrence, duration of postoperative drains, the incidence of systemic and wound-related complications, the need for percutaneous intervention or reoperation and quality- of-life with 3 years of follow-up. the study will be prospective and randomized, and the evaluator and patient will be blinded as to the type of mesh implanted.

Eligibility criteria:
inclusion criteria: * age 18 or older * grade ii or iii ventral hernia according to ventral hernia working group (vhwg) * pre-operative informed consent is obtainable exclusion criteria: * return to the operating room within the next 1 year for additional open abdominal surgery is anticipated * absence of fascial defect or fascial defect less than 3 cm in greatest dimension * presence of previously place mesh (synthetic or biologic) at the site of surgery, which will not be completely removed and will, in part or whole, remain at the site of implantation of the study mesh * concurrent placement of another mesh (synthetic or biologic) at the site where the study mesh is placed * grade iv ventral hernia according to vhwg system * asa score iv or above * any disease or condition along with the surgeon's clinical judgment that contraindicates the use of either study mesh * pregnancy
coracoid tunnel widening after acj tight rope fixation

Conditions: Orthopedic Disorder; Orthopedic Devices Associated With Misadventures

Summary: studying coracoid tunnel widening after arthroscopic fixation of acute acromioclavicular joint (acj) dislocation using tightrope system and its correlation with loss of reduction and the functional scores.

abstract purpose: to detect coracoid tunnel widening after arthroscopic fixation of acute acromioclavicular joint (acj) dislocation using tightrope system and its correlation with loss of reduction and the functional scores. methods: from july 2016 to dec 2018, a prospective study was performed at our hospital. twenty-three patients with acute grade iii-v acj dislocation were included in the study. arthroscopic double tight-rope repair of the acj was performed. coracoid tunnel widening was measured by computed tomography (ct) and coraco-clavicular distance was measured on the x-ray immediately post-operative and at 12 months. constant shoulder score, oxford shoulder score, nottingham clavicle score and visual analogue scale were used as outcome measures at 12 months. level of evidence iv keywords acute acromioclavicular joint injury . tightrope . coracoid tunnel dilatation. loss of reduction.

Eligibility criteria:
inclusion criteria: * patients with acute (≤ 3 weeks after injury) rockwood grade iii-v acj dislocation exclusion criteria: * patients with associated coracoid fracture, associated rotator cuff tears or glenohumeral arthritis

Keywords: acute acromioclavicular joint injury . tightrope . coracoid tunnel dilatation. loss of reduction.
microbial and environmental factors associated with polyps development in familial adenomatous polyposis (microbenvironment in fap)

Conditions: Familial Adenomatous Polyposis

Summary: familial adenomatous polyposis (fap) is an autosomal dominant inherited disorder linked to a mutation in the apc gene, associated with the development of multiple colonic and duodenal adenomas, which in 100% of cases progress to colorectal cancer (crc) if left untreated. management of affected patients is usually based on prophylactic total colectomy with or without rectal preservation, followed by regular endoscopic surveillance of the duodenum and rectum or ileal reservoir. however, there is considerable inter- and intra-familial variability in the rate of adenoma appearance and development for identical mutations. this strongly suggests the additional role of environmental factors. recently, the gut microbiota has been identified as a co-factor of carcinogenesis in patients with fap, but no prospective evaluation of the association between the incidence and severity of adenomatous proliferations and a microbiological signature has been studied, particularly at duodenal level in operated patient.


Eligibility criteria:
inclusion criteria: * ≥18 years * non-opposition obtained * prophylactic colectomy for at least 2 years in the context of apc-related familial adenomatous polyposis with ileorectal or ileoanal anastomosis * included in the national polypose database * regular endoscopic follow-up with upper and lower gi endoscopy at hôpital edouard herriot or hôpital de la croix-rousse * having performed at least 2 endoscopies as part of follow-up exclusion criteria: * antibiotic therapy within 2 months prior to stool sampling * taking probiotics for less than 1 month * person deprived of liberty by judicial or administrative decision

Keywords: familial adenomatous polyposis microbiota colorectal cancer nutrition
the analgesic efficacy of wound infiltration with tramadol

Conditions: Postoperative Pain

Summary: this double-blind, randomized trial examined whether tramadol wound infiltration decreased postoperative pain following cesarean delivery under general anesthesia or reduced the need for analgesics in the immediate postoperative period. patients in the tramadol group consumed significantly less morphine at all time intervals than those in the control group. the investigators suggest that the use of wound infiltration with tramadol may be a useful technique in patients who undergo cesarean section under general anesthesia to reduce postoperative pain, improve recovery, and facilitate early contact of mothers with their babies.


Eligibility criteria:
inclusion criteria: * nulliparity * gestation age between 37-40 weeks * cs under general anesthesia exclusion criteria: * pre-eclampsia * cardiovascular problems * allergy to any of the study medications * chronic preoperative pain * regular analgesic use

Keywords: tramadol postoperative analgesia infiltration cesarean section
nutritional deficiencies in the bariatric patients

Conditions: Morbid Obesity; Nutritional Deficiency

Summary: although morbidly obese subjects have larger than regular caloric intake, there is evidence that they suffer from nutritional deficiencies at a higher rate than the general population, probably because they eat mostly "unhealthy food."


Eligibility criteria:
inclusion criteria: * all morbidly obese subjects who are surgery candidates exclusion criteria: * previous bariatric operations
neonatal suspected sepsis treated with cefazolin or vancomycin

Conditions: Nosocomial Neonatal Sepsis

Summary: the objective is to evaluate the effectiveness of empiric treatment with cefazolin versus to vancomycin in newborn infants with presumptive clinical signs of hospital acquired bacterial sepsis probably caused by coagulase-negative staphylococcus. the investigators hypothesized that newborn infants with the presumptive diagnosis of nosocomial sepsis who received cefazolin as empiric treatment would have a clinical outcome not inferior to that of those treated with vancomycin.


Eligibility criteria:
inclusion criteria: * newborn infants older than three days of life with suspected bacterial sepsis and according to attending physicians, with an indication for initial treatment with vancomycin and at least one blood culture taken prior to receiving the antimicrobial treatment. exclusion criteria: * previous treatment with vancomycin during the week before, * infants referred from other hospitals and, upon admission, were being treated with antibiotics.

Keywords: coagulase negative staphylococcus nosocomial neonatal sepsis cefazolin vancomycin newborn
fit and strong! plus comparative effectiveness trial

Conditions: Osteoarthritis; Overweight and Obesity

Summary: this randomized controlled trial is comparing outcomes of customary fit and strong!, to fit and strong! plus, an enhanced version of the program that incorporates weight management. we hypothesize that fit and strong! plus participants will show improved diet behaviors at 2, 6, 12, and 18 months that will be accompanied by a significant 5% weight loss at 6 months and maintained to 18 months, compared to participants in customary fit and strong!.


Eligibility criteria:
inclusion criteria: * presence of symptoms of lower extremity osteoarthritis * age 60 or older * not currently participating in a regular physical activity program * bmi 25-50 * able to attend fit and strong! classes exclusion criteria: * score of 3 or greater on mental status questionnaire * recent hip or knee surgery * recent steroid injection into hip or knee * diagnosis of rheumatoid arthritis * uncontrolled diabetes * unspecified health conditions that may interfere with exercise
the effectiveness of autonomic nervous system, sleep quality, and immune regulation for shift nurses practicing alternative nostril breathing

Conditions: Shift Nurses

Summary: the purpose of this study is to evaluate the efficacy of shift nurses practicing alternative nostril breathing to improve life quality, autonomic nervous system and immune status.

breathing is regulated by autonomic nervous system. it is well-known that breathing exercise can regulate autonomic nervous function and promote relaxation. however, the mechanism for better immunity and sleep quality is not clear. we postulate that alternative nostril breathing might benefit nurses after undergoing shift work. the benefits could be due to improvement of autonomic nervous function, sleep quality, and even immune function. the study design will include a randomization of two groups, with a control group and one experimental groups for 3 months (12 weeks). the control group will do normal breathing. the experimental groups will do alternative nostril breathing twice a week (20 minutes/time) for 3 months. the study primary endpoints are 1) to improve autonomic nervous function, 2) to improve sleep quality and 3) to enhance human immunity. we anticipate to reach the primary endpoints and publish the primary results in one year.

Eligibility criteria:
inclusion criteria: * shift nurses exclusion criteria: * upper respiratory tract infection such as nasal congestion, runny nose, coughing, wheezing, nosebleeds, fever and other symptoms.
dry needling and exercises in shoulder pain

Conditions: Shoulder Pain

Summary: shoulder pain is highly prevalent in the society. the role of muscle tissues in this pathology has received increasing interest. some studies have proposed the role of myofascial trigger points in this population. the purpose of the current clinical trial is to compare the effects of physiotherapy treatment consisting of an eccentric exercise protocol versus the same physical therapy program plus the addition of trigger point dry needling (trp-dn) on pain and function in patients suffering from unspecific shoulder pain.


Eligibility criteria:
inclusion criteria: * unilateral non-traumatic shoulder pain * shoulder pain from at least 3 months * shoulder pain of more than 4 points on a nprs exclusion criteria: * bilateral shoulder symptoms * younger than 18 or older than 65 years * history of shoulder fractures or dislocation * cervical radiculopathy * previous interventions with steroid injections * fibromyalgia syndrome * previous history of shoulder or neck surgery * any type of intervention for the neck-shoulder area during the previous year

Keywords: dry needling trigger point eccentric exercise
painful diabetic peripheral neuropathy study of chinese outpatient

Conditions: Painful Diabetic Peripheral Neuropathy

Summary: painful diabetic peripheral neuropathy study of chinese outpatient (pdn-scope): a multi-center cross-sectional registry study of clinical characteristics and treatment survey of pdn in china

painful diabetic peripheral neuropathy (pdn) presents a serious health problem in china. scope is a cross-sectional, multi-centers registry study with a target sample size of 1500 patients who are experiencing pdn. the patients are treated following guideline and local practice. real-world data including demographics, medical histories, vas, phq, gad -7 and therapies are collected. the primary objective is to analyze the clinical characteristics of pdn. the secondary objectives include anxiety depression distribution and current treatment status.the scope study will help to find actual clinical manifestation and treatment and improve the overall treatment outcome of chinese patients with pdn.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older patients 2. definite diagnosis of type i and type ii diabetes 3. evidence of symptoms, signs and/or electrophysiology of diabetic peripheral neuropathy 4. complains of spontaneous pain (continuous or intermittent needle pricking, electric pain, burning pain etc.) or induced pain (hypersensitivity, sensory inversion). 5. the pain lasts for at least 3 months 6. signed informed consent exclusion criteria: 1. other causes of neuropathic pain, non-neuropathic pain or mixed pain, such as neck / lumbar degenerative disease, arthritis, nerve root compression, para-neoplastic syndrome, cerebrovascular disease, spinal cord diseases and other peripheral neuropathy (immunity, toxic and nutritional neuropathy etc.) 2. dementia, substance abuse etc. and other conditions seriously affecting cognitive and communication skills
tdcs coupled with virtual rehabilitation for negative symptoms in at-risk youth

Conditions: Clinical High Risk for Psychosis

Summary: negative symptoms, which include the loss of motivation, social withdrawal and reduced emotional expression are prominent in youth at clinical high risk (chr) for psychosis. these negative symptoms lead to significant functional impairment and enduring disability in these youth. at present, there are no established treatments for negative symptoms. recent evidence from independent studies, however, suggests two promising novel treatment approaches for negative symptoms, transcranial direct current stimulation (tdcs), and computerized remediation strategies. the primary aim of this study is to evaluate if tdcs combined with a virtual reality-based computerized remediation (vr) is effective for treating negative symptoms in chr youth, thereby mitigating the enduring functional disability these symptoms cause.

negative symptoms, which include amotivation, social withdrawal and diminished emotional expression are prominent in youth at clinical high risk (chr) for psychosis. negative symptoms lead to significant functional impairment and enduring disability in these youth regardless of subsequent conversion to psychosis. at present, there are no established treatments for negative symptoms. recent evidence from independent studies, however, suggests two promising novel treatment approaches for negative symptoms, transcranial direct current stimulation (tdcs), and computerized remediation strategies, both of which have revealed significant therapeutic effects on negative symptoms in schizophrenia (sz). tdcs involves delivery of a low intensity continuous electrical field to the frontal cortex. tdcs is very safe and well tolerated, and is currently being investigated as a treatment for several psychiatric disorders. tdcs is also health canada approved for the treatment of major depressive disorder. the primary aim of this randomized controlled trial is to evaluate if tdcs combined with a virtual reality-based computerized remediation (vr), administered three times per week for four weeks, is effective for treating negative symptoms in chr youth, thereby mitigating the enduring functional disability these symptoms cause.

Eligibility criteria:
inclusion criteria: 1. between the ages of 16 and 30; 2. meet chr criteria for a psychosis risk syndrome determined by the structured interview for prodromal symptoms (sips); 3. have a scale of prodromal symptoms (sops) negative subscale (sops-neg) score of \> 11, with at least one negative symptom of at least moderate severity (i.e., ≥ 3) exclusion criteria: 1. meet criteria for a current or lifetime psychotic disorder; 2. have an iq \< 70; 3. a history of seizures or clinically significant neurological disorder that may contribute to prodromal symptoms. 4. have been involved in another treatment study in the past 4 weeks.
the development of allergic rhinitis in children previously diagnosed as nonallergic rhinitis

Conditions: Allergic Rhinitis (Disorder)

Summary: the purpose of this study is to evaluate development of allergic rhinitis in children with nonallergic rhinitis.

rhinitis is a common condition associated with significant effects on quality of life. rhinitis may be divided into two groups, those with concurrent allergy (allergic rhinitis, ar) and those without allergy but who still suffer from nasal symptoms (nonallergic rhinitis, nar). evidence indicated that adult with nar can have de novo sensitization to aeroallergen (24%), suggesting that patients with nar might evolve to ar. thus the purpose of this study is to evaluate development of allergic rhinitis in children with nonallergic rhinitis.

Eligibility criteria:
inclusion criteria: * children between the age of 1 year and 15 years with the diagnosis of nonallergic rhinitis who are attending the pediatric allergy clinic during jan 2005 - dec 2007. exclusion criteria: * patients who have allergic rhinitis and underlying disease eg.chronic renal disease, liver disease, heart disease, cancer.

Keywords: nonallergic rhinitis allergic rhinitis development
a study to compare analytes in blood collected using an investigational collection device with a commercial predicate

Conditions: Diabetes; Anemia

Summary: this study will involve an investigational device, the seventh sense biosystems tap20-c. the tap20-c device collects small amounts of blood from the forearm which can then be used for blood testing. the study will also involve collecting blood by fingerstick which is a common way of collecting blood. the safe-t-fill capillary blood collection system and the terumo capiject 1.5 mm blade safety lancet will be used for this. the study will compare the concentrations of glucose, hemoglobin, and hba1c in blood samples collected with the two different blood collection methods. additional information will be collected about how the tap20-c device performs.


Eligibility criteria:
inclusion criteria: healthy subject group 1. male and female volunteers 18 years of age or older diabetic subject group 1. male and female volunteers 18 years of age or older 2. have been diagnosed with type 1 or type 2 diabetes mellitus by self-report exclusion criteria: 1.subjects who are pregnant or nursing mothers by self report 2.subjects who have eaten or consumed sugar-containing drinks in the 2 hours before blood sample collection begins 3.subjects with a history of skin disorders or who present with abnormal skin integrity or atypical skin health within the areas to be tested 4.subjects with a missing index or middle finger on either hand or a missing forearm 5.subjects who have known allergies to titanium -
the effect of metformin on breast cancer patients

Conditions: Breast Cancer

Summary: several clinical trials have addressed the promising anticancer effect of metformin on the survival benefits, clinical response, and pathological response of breast cancer patients. therefore, this study will assess the anticancer effect of metformin when added to the neoadjuvant chemotherapy protocol of non-diabetic breast cancer patients. in addition to, the impact of metformin addition to the neoadjuvant chemotherapy on the quality of life of breast cancer patients.

this study is conducted to assess the effect of metformin addition to the chemotherapy protocol of non-diabetic breast cancer patients compared to the control group (non-metformin users) in the neoadjuvant setting. evaluation of the the clinical benefit rate and the rate of pathological complete response will be conducted. in addition, a correlation between the beneficial effect of metformin and the serum concentration of metformin. also, a comparison in the quality of life between the metformin group and the control group will be evaluated using the european organization for research and treatment of cancer quality of life questionnaire (eortc qlq c30) and (eortc qlq br45) questionnaires will be done.

Eligibility criteria:
inclusion criteria: 1. non-diabetic breast cancer patients, receiving neoadjuvant chemotherapy treatment. 2. female age between 18- 65 years. 3. written informed consent. exclusion criteria: 1. known hypersensitivity reaction to metformin. 2. intolerable metformin gi complaints. 3. patients at risk of lactic acidosis. 4. diabetic breast cancer patients. 5. body mass index \< 18.5 (underweight breast cancer patients). 6. renal impairment, egfr \<45 ml/min/1.73 m².

Keywords: metformin breast cancer