Kornimate/medical-research-clean huggingface dataset:
periodontal treatment and psychology

Conditions: Gum Disease

Summary: there is a relationship between depression and periodontal disease. this relationship may be double-sided. a psychological state such as anxiety, depression, body image, and self-esteem may be affected from the symptoms of periodontal disease.

background: depression is a multi-factorial disease characterized by a variety of symptoms. psychiatric disorders seem to be more prone to periodontitis compared to patients without psychiatric disorders. however periodontal disease and depression can be considered bidirectional risk factors. periodontal disease can also be an effect on depression. the aim of this randomized controlled clinical study is to determine the effect of non-surgical mechanical periodontal treatment on psychological state. material and methods: the study population consisted of 184 depressed patients with non-treated periodontal diseases. two randomized group is formed from these patients. immediately periodontal treatment (test group, n = 92) and delayed periodontal treatment (control group, n = 92). clinical periodontal and psychological measures were performed at baseline and 6th weeks on control and test group.

Eligibility criteria:
inclusion criteria: * the presence of periodontal diseases, * the presence of diagnosed minor depression * being under maintenance therapy regarding the depression exclusion criteria: * any hormonal condition such as pregnancy or lactation * received any periodontal treatment within six months

Keywords: periodontal disease depression body image self-esteem
study of quantification of hyperpronation

Conditions: Foot Pain Chronic

Summary: hyperpronation is af frequent cause of excessive load in foot and crus. pain and limited functional ability cause problems with work-related activities, sport activities and leisure activities. there are only few studies of the frequency of pain related to hyperpronation in foot and the effect of exercises. medics and physiotherapists need sufficient evidence-based knowledge to treat these patients correctly. therefore, the investigators want to study the effect of exercises and inner soles for treatment of patients with chronic pain and hyperpronation of foot.


Eligibility criteria:
inclusion criteria: * hyperpronation of foot * consent of information exclusion criteria: * normal gait * lack of consent of information * unable to speak and read danish

Keywords: pain foot
impact of anti pd-1 therapy in children, adolescents and young adults (caya) melanoma patients

Conditions: Early Melanoma; Advanced Melanoma

Summary: this is a retrospective observational cohort study, the primary objective is investigate the activity and efficacy of anti pd-1 antibodies in children, adolescents and young adult melanoma patients, with radically resected or metastatic disease

the aim of the study is to evaluate the activity and efficacy of anti pd-1 antibodies in adolescent, childhood and young adult with early and advanced melanomas through a multicenter transnational european retrospective analysis clinical outcomes will be retrospectively retrieved beginning from the primary diagnosis of melanoma. clinical outcomes will be retrospectively evaluated starting from the time of start of treatment for up to a the most recent follow-up. data collected will include demographic information, disease history, baseline conditions, clinical outcomes of interest.

Eligibility criteria:
inclusion criteria: 1. patients of either sex aged ≥ 12 years; 2. histologically confirmed melanoma; 3. anti pd-1 immunotherapy (ipilimumab plus nivolumab); 4. previous and subsequent treatments will be collected; 5. clinical and follow-up data available exclusion criteria: 1. no immunotherapy received; 2. no melanoma; 3. age \> 30 yrs

Keywords: pd-1 antibodies, childhood, adolescent, melanoma
increased risk of vte and higher hypercoagulability in patients recovered in icu and in medical ward for covid-19

Conditions: COVID-19 Disease; Thromboembolism, Venous

Summary: the aim of this study is to verify if patients admitted to hospital in a medical division and in the intensive care unit for a covid-19 infection are at higher risk of developing a vte complication and if they actually present an increased hypercoagulable state.

between december 2019 and january 2020, a new type of coronavirus, named as "coronavirus disease 2019 - covid-19" by the world health organization, has widely spread throughout the world, becoming a global health threat. the new covid-19 is similar to other two types of coronavirus that in the past two decades have emerged as cause of severe human disease: severe acute respiratory syndrome cov (sars-cov) and middle east respiratory syndrome cov (mers-cov). severe respiratory disease or respiratory failure are the principal symptoms of critical patients, needing a management in icu with mechanical ventilation.18 data coming from laboratory results show a leucopenia mainly represented by a lymphopenia, that is a cardinal feature of covid-19. moreover, the concentration of several serum pro-thrombotic cytokines, such as interleukins (mainly il-6, increased in 52% of patients), tnf-α, d-dimer are reported to be significantly higher in covid-19 patients, and significantly higher in icu-patients than in non-icu patients, suggesting an increased hypercoagulable state that, joined to the other main risk factors (immobilization, icu admission, mechanical ventilation, infective disease), place these patients to a potential greater risk of developing vte complications.

Eligibility criteria:
inclusion criteria: * aged \>= 18 years * needing admission to a medical hospital division or to an icu * with a confirmed infection for covid-19 exclusion criteria: * aged \< 18 years

Keywords: covid-19 pandemic thromboembolism, venous deep venous thrombosis pulmonary thrombosis
effect of music therapy intervention on pain after gynecological surgery

Conditions: Pain

Summary: to evaluate the effect of musical therapy before and after gynecological surgeries on pain relief following surgery. the hypothesis is that musical therapy is effective in pain relief following surgical procedures.

the intention with the study is to focus on the first postoperative phase in a case of pain upon gynecologic abdominal surgery. the literature search revealed studies reporting that participates who had pre-operative session of music intervention for relaxation experienced a greater level of reducing pain levels both pre and post their operation than in the participates in the control group. it is therefore a decision to include one pre operative session of intervention with music therapy in the design. the study will carry out at the gynecologic unit, in rambam hospital, israel.

Eligibility criteria:
inclusion criteria: * women are schedule to undergo gynecological surgeries exclusion criteria: * neuropathy * neurological conditions * diabetes

Keywords: music therapy pain gynecological surgeries
promoting male involvement to improve prevention of mother to child transmission (pmtct) uptake and reduce antenatal infection

Conditions: HIV; Pregnancy

Summary: this study will evaluate the impact of combining two evidence-based interventions: a couples risk reduction intervention with an evidence based medication adherence intervention designed to enhance male participation in combination with improving medication and prevention of mother to child transmission (pmtct) adherence in antenatal clinics (ancs). clinics will be randomly assigned to experimental and control conditions and effectiveness of the combined intervention to enhance pmtct as well as reduce antenatal seroconversion by both individuals and clinics will be examined. it is hypothesized that community clinics implementing partnerplus will have more effective pmtct program adherence, as measured by total participant 1) maternal and paternal anc and partnerplus visits, 2) maternal and paternal human immunodeficiency virus (hiv) counseling \& testing (hct) uptake, 3) maternal and infant antiretroviral (arv) prophylaxis uptake, 4) maternal highly active antiretroviral therapy (haart) uptake, 5) infant polymerase chain reaction (pcr) for hiv, and 5) maternal and infant hiv serostatus and that community clinics implementing partnerplus will have reduced sexual risk behavior, as measured by participant sexual barrier use.

this study is a group-randomized controlled trial using a 2 x 6 comparison (clinic, experimental, control x time, baseline, post-intervention, pre-delivery 32 weeks, pre-delivery day, delivery, post partum). twelve community health centers (chcs) in communities within the gert sibande and nkangala districts in mpumalanga, south africa (sa) will be randomly assigned to condition in a 1:1 ratio. six usual care condition clinics will provide the standard of care, pmtct; six experimental condition clinics will offer partnerplus to mothers completing hiv testing, regardless of serostatus, who are willing to enroll with their male partners and participate in the integrated partnerplus intervention. this study will recruit 240 couples (n = 480 individuals); community clinics will recruit 2 cohort per clinic over 3 months (10 couples per cohort, n = 40, 120 individuals per condition).

Eligibility criteria:
inclusion criteria: * pregnant women age 18 and older who have received hct (hic counseling \& testing) at the antenatal clinic (anc), * willing to attend partnerplus or prevention of mother to child transmission (pmtct) visits with their male partners, * male partners must also be available to participate and * both partners must be willing to participate in the study. * all participants will be current adult residents of mpumalanga province and agree to be attend four group sessions, 2 psychosocial assessments and 1 three day post-delivery assessment (maternal and infant blood sample). exclusion criteria: * single mothers not being tested for hiv at the anc

Keywords: hiv pregnancy prevention couples
the clinicopathological and prognostic factors of hepatocellular carcinoma; 10 years' tertiary center experience in egypt

Conditions: Hepatocellular Carcinoma

Summary: this study aimed at study the clinical and pathological criteria of hepatocellular carcinoma to keep with new challenging in diagnosis and morpho-molecular classifications


Eligibility criteria:
inclusion criteria: * all pathologically proven hepatocellular carcinoma exclusion criteria: * other malignant tumors than hepatocellular carcinoma * benign tumor
efficacy of hip belt squat training on pain management and physcial function in low back pain patients

Conditions: Low Back Pain

Summary: the purpose of this project is to investigate the efficacy of the hip belt squat exercise in pain management and physical function for people with chronic low back pain.

this study is a randomized controlled trial (rct) designed to evaluate the effectiveness of a 12-week hip belt squat (hbs) intervention for patients with non-specific low back pain (lbp). participants, aged 18-60 with lbp for more than 12 weeks, are randomly assigned to either the intervention group or a control group. the control group will not receive any intervention, whereas the hbs intervention consists of two supervised sessions per week for 12 weeks, with load adjustments based on perceived exertion. the study aims to recruit 50-60 patients to ensure sufficient statistical power. primary outcomes include health-related quality of life (eq-5d-5l), fear-avoidance beliefs (fabq), functional ability (odi), risk of chronicity (startback), pain intensity (vas), and pain sensitivity (ppt). secondary outcomes include body composition (dexa), lumbar flexibility, maximal muscle strength (5rm), physical activity (gpaq), tobacco use (sq), and work-related stress (wsq). measurements are taken at baseline, 6 weeks, 12 weeks, and a 1-year follow-up for various outcomes. this comprehensive approach aims to provide valuable insights into the effectiveness of the hbs intervention for managing lbp.

Eligibility criteria:
inclusion criteria: * men and women with non-specific low back pain for more than twelve weeks, with a vas score of at least 3, taken as an average of the last week, and odi\>20 exclusion criteria: * leg pain greater than back pain * neuromuscular disorders * spinal or lower extremity fractures * infections * cancer * osteoporosis * dementia * current substance abuse * former lumbar surgery * persistent pain syndromes other than back pain * inflammatory rheumatic diseases
mindspace strategy for risk optimization

Conditions: Stroke

Summary: the purpose of this study is to find out which types of written stroke messages may help high risk stroke patients take action to improve their health.

in this project, the investigators will draw on the science that has provided a foundation for behavioral economics as a guide to activation interventions. specifically, the investigators will use the mindspace framework that was created by some of the founders of behavioral economics. that framework details nine approaches to behavioral activation that have particularly solid evidence bases. two of these, salience and incentives, the investigative team identified as most promising and practical for stroke activation. aims: 1. use electronic health record data to construct framingham stroke risk scores in both richard l. roudebush veterans affairs medical center and eskenazi health system. 2. conduct iterative testing with high risk stroke patients from both health systems to refine two different stroke risk messages based on the behavioral strategies of salience and incentives. 3. conduct a randomized trial of four mailed stroke risk messages, comparing the impact on patient activation of: 1) a standard stroke risk message, 2) a salience-focused stroke risk message, 3) an incentive-focused stroke risk message, and 4) a salience plus incentive message. 4. compare the proportion in each messaging group that completes a stroke risk factor relevant healthcare system visit within two months of receiving the stroke risk message.

Eligibility criteria:
inclusion criteria: * • high risk stroke patients 18 years of age or older, as determined by calculation of a framingham stroke risk score * at least one primary care visit 12 months prior to study initiation with the richard l. roudebush va medical center (vha) or sidney \& lois eskenazi (ehs) health system primary care clinics exclusion criteria: * • patients with at least one primary care provider visit in the prior 12 months in both the va and ehs systems
hp improves sleep and overall survival rate in maintenance hemodialysis patients

Conditions: Hemoperfusion

Summary: sleep disturbance has been long-standing torments in most of patients with maintenance hemodialysis (hd). in this study, we attempted to explore whether long-term hemoperfusion (hp) could improve sleep disorder and increase overall survival rate in hd patients.


Eligibility criteria:
inclusion criteria: 1. duration of maintenance hd should be equal or more than 3 months, 2. patient's age should be equal or more than 18 years exclusion criteria: - i) he/she diagnosed with malignant tumors, an active rheumatism, infectious diseases, or a severe heart failure ii) he/she would disagree with the study 3. he/she has received a short-term poor prognosis 4. he/she would be more than 80 years old
systemic metabolic contribution from continuous renal replacement therapy (crrt)

Conditions: Acute Kidney Injury

Summary: the purpose of this observational study is to measure the number of calories delivered from fluids used in continuous renal replacement therapy (crrt). we are doing this research study because the fluids used in this treatment may deliver an important number of calories. in the future this could help better estimate how much nutrition patients in the critical care unit should get every day from other sources like tube feeding or nutrition through a person's veins.

the goal of this study is to quantify the specific metabolic contribution of standard continuous renal replacement protocols (including citrate anticoagulation) in the intensive care unit patient population at mayo clinic in rochester, minnesota utilizing a prospective, observational study. this data will allow practitioners to better tailor caloric provision with nutrition support programs, minimizing the risk of overfeeding in this complex critical care patient population.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * patients in an intensive care unit anticipated to receive greater than or equal to 24 hours of continuous venovenous hemofiltration. * receiving regional citrate anticoagulation with acd-a solution. exclusion criteria: * vulnerable adults * pregnant * bmi \> 40 * patient on extracorporeal membrane oxygenation therapy * reversal of port connections on the dialysis catheter and dialysis circuit lines

Keywords: nutrition crrt cvvh citrate anticoagulation caloric uptake
bisoprolol in dmd early cardiomyopathy

Conditions: Duchenne Muscular Dystrophy; Cardiomyopathy, Dilated

Summary: this study aimed to use cardiac magnetic resonance imaging (cmr) to evaluate the efficacy and safety of bisoprolol therapy for boys with duchenne muscular dystrophy(dmd) and preserved ejection fraction. on top of angiotensin-converting enzyme inhibitor (acei) , half of the participants will receive bisoprolol in combination, while the other half will not receive any beta-blocker.

by the age of 20 years, almost all the patients with duchenne muscular dystrophy(dmd) have experienced dilated cardiomyopathy (dcm), a condition that contributes significantly to their morbidity and mortality. studies have shown acei to be an effective therapy for dmd boys with early cardiomyopathy. although bisoprolol has been demonstrated as an effective neurohumoral drug for adult patients with dcm, few data exist concerning its safety and efficacy for the patients with dmd. the investigators hypothesize that the treatment with bisoprolol in addition to background acei therapy for 12 months in participants with dmd and early myocardial damage evident with late gadolinium enhancement and preserved ejection fraction, would blunt decline in left ventricular systolic performance.

Eligibility criteria:
inclusion criteria: * older than(including) 7 years old * a definite diagnosis of dmd with muscle pathology confirming the expression of dystrophin lower than 5% and/or confirmed mutations in the dmd gene using a clinical accepted technique that completely defines the mutation. * using acei or arb for more than 1 month * confirmed myocardial damage in one or more left ventricular segments evident by late gadolinium enhancement and preserved left ventricular systolic function(\>45%) by cine cardiac mr in 45 days * normal renal function * holter and blood pressure shows no contraindication of using bisoprolol exclusion criteria: * having metal implanted in body * having claustrophobia * allergic to gadolinium * complicated with other cardiovascular diseases * medical history or holter show bradyarrhythmia like ii/iii degree atrioventricular block, sick sinus syndrome etc. * systolic blood pressure lower than 90mmhg or rest heart rate lower than 75bpm * having copd or asthma history * having other complications: tumor, endocrine diseases * having beta blockers therapy * planned operation in the future 12 months * allergic to bisoprolol

Keywords: duchenne muscular dystrophy early cardiomyopathy bisoprolol
neurofeedback to treat depression

Conditions: MDD

Summary: this study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with mdd (60 in r61 phase and 80 in r33 phase). this real-time fmri neurofeedback therapy uses cloud-based pattern classification to decode a patient's attentional state and dynamically modulate task stimuli (in a closed loop) based on this state.

in both the r61and r33 phases we will compare cloud based real time fmri feedback with placebo (sham feedback) in reducing negative attention bias and depressive symptoms. this study will be the first dose-finding test of real-time fmri effect on negative attention bias. measures include: structured clinical interview for dsm-5 (scid), clinician-administered diagnostic exam, montgomery asberg depression rating scale (madrs), clinician-administered scale used to assess the severity of depression, state-trait anxiety inventory (stai), self-report questionnaire used to measure types of anxiety and mood symptoms, mood and anxiety symptom questionnaire (masq), negative perseveration during a go/no-go task, go/no-go task with overlaid face/scene stimuli; brain response triggers next stimulus, negative gaze, negative gaze collected in gaze data following each real time fmri feedback session

Eligibility criteria:
inclusion criteria: * gender, inclusive * adult aged 18 - 65 meets diagnostic and statistical manual of mental disorders (dsm-5) criteria for mdd according to the clinician-administered mdd scale for dsm-5 (unipolar depression or bipolar ii depressed) * scores at least a minimum score of 16 on montgomery asberg depression rating scale (madrs) * normal cognition * participants must be able to read and understand english * participants must be able to provide consent exclusion criteria: * pregnancy (female participants) * outside age range * mri contraindications (medical implant, claustrophobia, etc.) * use of psychoactive medication (including antidepressants) or currently in therapy * neurological disorder or any condition that in the view of the pi could impact brain data, cause depression, require medication that could cause depressive symptoms, or otherwise result in participant being unfit for study (for example, co-morbid psychotic, neurological disorders, developmentally or cognitively disabled/impaired, active alcohol or drug abuse/dependence within the past 6 months). * non-english speaking * non-correctable vision loss * refusal to provide informed consent * representing an active suicide risk
opioid use after traumatic injury in adolescents

Conditions: Opioid Use; Traumatic Injury; Adolescent Behavior; Substance Abuse Disorder

Summary: currently, 1 in 8 adolescents continue to receive prescription opioids a year or more after injury. by longitudinally surveying patients, we can identify risk factors and pathways to nonmedical opioid use. furthermore, by assessing whether pain management and mental health treatment after injury moderates sustained opioid use and prescription opioid misuse, we can create targeted interventions to reduce future nonmedical opioid use in adolescents.

this is a prospective cohort study that will follow participants for 2 years and administer surveys to adolescents both traumatically injured and uninjured on prescription opioid usage, substance use, utilization of pain management and mental health services, and mental and physical health condition conditions.

Eligibility criteria:
inclusion criteria: * patient is 12-20 years of age * adolescent admitted for trauma or adolescent with no recent trauma * english speaking * consent can be obtained from a parent or guardian exclusion criteria: - patients with severe brain injuries or other injuries that prevent survey participation