Kornimate/medical-research-clean huggingface dataset:
study of plga-mg material in clinical orthopedics

Conditions: Fracture Dislocation

Summary: the different proportion samples of plga-mg were made in this study. then, they would be placed in the femoral condyle of the new zealand rabbits. the appropriate proportion of plga-mg is obtained after the experiment, which will be used to make the plate or screw to fix the fragments. then, the clinical role for bone will be assessed.

the deposition of calcium could be facilitated by the increase of magnesium, which played an important role in fracture union. however, its degradation may be completed before the fracture line was disappeared. in addition, the hydrogen may be released during degradation. thus, its clinical popularization was limited. as a new polymer material, poly lactic-co-glycolic acid (plga) has been widely used clinically. the hydrolytic production of plga was acidic, which could neutralize the alkalinity of production degraded from magnesium. in addition, it was a long time before the total accomplishment of degradation of plga, which may postpone the degradation of magnesium. the different proportion samples of plga-mg were made in this study. their physical and chemical properties were analyzed to estimate its safety of implantation. then, they would be placed in the femoral condyle of the new zealand rabbits. the osteogenesis and complication of samples are examined to select an appropriate proportion of plga-mg is obtained. then, the plga-mg material will be used to fix the fracture of human as a fixation. the review of the patients will be conducted to assess its clinical role.

Eligibility criteria:
inclusion criteria: * 18-65 years old * closed fracture * sign the agreement of the experiment exclusion criteria: * pathologic fracture * open fracture * refused to participate * follow-up insufficient 12 months

Keywords: plga-mg fracture fixation union
cognitive functional therapy (cft) compared with core training exercise and manual therapy (core-mt) in patients with chronic low back pain

Conditions: Low Back Pain; Back Pain; Pain; Signs and Symptoms; Neuromuscular Manifestations

Summary: there is evidence, of a single randomized controlled trial, that cft is better than combined manual therapy and motor control exercise for chronic low back pain. however, this study had significant methodological shortcomings regarding the failure to carry out the intention to treat analysis and a considerable loss of follow-up of patients. as it is, it is important to carry out more studies involving cft compared to other interventions already used in clinical practice and to correct these methodological shortcomings. therefore, the aim of the study is to assess the efficacy of cognitive functional therapy in patients with chronic non specific low back pain.

randomized controlled trial with concealed allocation, blinded assessor, blinded participants and intention to treat analysis. patients will be evaluated at baseline, 8 weeks, 6 and 12 months after randomization, to assess the maintenance of any effect of treatment. the patients in the cft group will be treated by a physical therapists that attended twice the cft workshops with two of the tutors of the method. she completed 106 hours of training including workshops, patient examinations and a pilot study with the supervision of a physical therapist with more than three years of clinical experience in cft. patients in core-mt group will be treated by a physical therapist with clinical experience in manual therapy and core training exercises.

Eligibility criteria:
inclusion criteria: * aged between 18 and 65 years * low back pain for more than 3 months * disability score of 14% or more on the oswestry disability index (odi) * being able to walk independently with or without support * understand portuguese well enough to be able to fill in the questionnaires exclusion criteria: * main pain area is not the lumbar spine (from t12 to buttocks) * main pain as leg pain (eg: nerve root compression or herniated disc with radicular pain / radiculopathy, lateral and central stenosis) * less than 6 months after lumbar spine, lower limb or abdomen surgery * invasive procedures for pain relief (ex: epidural injection, rhizotomy) in the last 3 months * pregnancy * inflammatory/rheumatological diseases (e.g., rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, systemic lupus erythematosus, scheuermann's disease)

Keywords: back pain physiotherapy exercise therapy cognitive functional therapy low back pain backache lower back pain lumbago multidimensional biopsychosocial
efficacy and safety of quadruple therapy in eradication of h. pylori: a comparison to triple therapy

Conditions: Helicobacter Infections

Summary: this study aims at evaluating efficacy and safety of quadruple therapy (bismuth, metronidazole, tetracycline and omeprazole: obmt) vs triple therapy (amoxicillin, clarithromycin and omeprazole: oac) in h. pylori eradication. it is hypothesized that quadruple therapy will be comparable in efficacy to triple therapy. subjects with confirmed h. pylori positive status will be randomized to one of the treatments described above. at week 6 and 10 follow-up visits, a urea breath test (ubt) will be performed to confirm eradication.

the study will include three phases: screening, treatment and follow-up. screening: this phase will last a maximum of 30 days and subjects eligibility will be evaluated after informed consent signature. endoscopy and urea breath test will be performed in addition to the baseline routine evaluations. treatment: subjects assigned to oac will be treated for 7 days. those assigned to pylera will be treated for 10 days. a randomization visit will take place on day 0 and an end-of-treatment visit will take place between day 8 and 14. follow-up: includes two visits. approximately one and two months post-treatment. eradication of h. pylori will be confirmed through ubt, and resistance will be evaluated in case of treatment failure. these subjects will undergo an endoscopy.

Eligibility criteria:
inclusion criteria: * positive h. pylori status; * presence of upper gastro-intestinal symptoms; * mental and legal ability to sign informed consent. exclusion criteria: * previous surgery of the gi tract; * clinically significant impairment of renal or hepatic function; * severe unstable cardiovascular, pulmonary or endocrine disease; * barrett's oesophagus or high-grade dysplasia; * dysphagia or vomiting as major symptoms.

Keywords: h. pylori quadruple therapy eradication rate multinational trial resistance to antibiotics subjects with confirmed helicobacter pylori infection
outpatient percutaneous coronary intervention

Conditions: Coronary Artery Disease

Summary: to determine the safety and feasibility of same day discharge after elective coronary percutaneous intervention in a selected stable patient population. the hypothesis to be tested is that in an appropriately selected stable coronary artery disease population post percutaneous coronary intervention, early discharge is safe and feasible.

a select stable population of patients undergoing percutaneous coronary intervention are randomized to standard of care in-hospital stay for one night or early discharge to a nearby hotel. during pci, patients receive bivalirudin as their anti-coagulant and also must be eligible for an angioseal closure device. patients that stay overnight in the hotel must be accompanied by a family member. they return to the cath lab the next day for groin check and blood work. satisfaction questionnaires are filled out by all patients.

Eligibility criteria:
inclusion criteria: * patients with stable coronary artery disease scheduled for elective percutaneous coronary intervention exclusion criteria: * patients with acute coronary syndrome, patients with an mi within 30 days, an ejection fraction \ 2.2, those with increased risk of infection, those with history of bleeding diathesis or anemia (hemoglobin\<11.0 g/dl, platelets \<100,000 tho/ul)

Keywords: percutaneous coronary intervention
the nor-cor study for coronary prevention

Conditions: Secondary Coronary Prevention

Summary: the nor-cor study is a cross-sectional, observational study designed to explore a large number of cardiovascular, inflammatory, genetic, behavioral, and psychosocial factors (including anxiety, depression, quality of life) in 1369 patients with established coronary heart disease (chd) hospitalized in the sections for cardiology at the hospitals in drammen (n=722) and vestfold (n=647). study data from an extensive questionnaire, clinical and laboratory data, and sputum/saliva for genetic analyses will be collected. the main overall aim of the nor-cor study is to develop new strategies to improve secondary prevention for underserved high risk patient-groups with chd. the first study phase aims to collect information necessary to develop empirically based future secondary coronary prevention interventions. in a genetic sub-project markers associated with chd and personality type will be explored. the study will evaluate current secondary preventive programs and explore the mechanisms that link behavioral, psychosocial, inflammatory, and genetic factors to poor prognosis. the study will in short term provide new knowledge potentially useful for increasing participation in current cardiac rehabilitation/secondary preventive programs. for a longer perspective these associations may be useful for design of new intervention programs to selected high risk patient groups whom may be in need of programs with different content and/or of longer duration than those currently being applied.


Eligibility criteria:
inclusion criteria: all patients aged 18-80 years with first or recurrent diagnosis or treatments for chd: a) acute myocardial infarction \[icd-10; i21\], b) coronary artery by-pass graft operation (cabg), or c) elective or emergency pci \[icd-10; i25\]) have been identified from hospital patient discharge lists (diagnostic lists) by searching chronologically after last admission the past three years. in patients with recurrent diagnosis the last event will define the event. exclusion criteria: * cognitive impairment that would invalidate assessment including all patients living at nursing home and psychosis. * short life expectancy (i.e. \<1 year) due to terminal heart (nyha class 4), lung (chronic obstructive pulmonary disease gold 4)-, liver- or kidney disease (chronic kidney disease stage 5), malignant disease, or other reason. * not able to understand and write the norwegian language or refuse to give written informed consent to study participation.

Keywords: secondary coronary prevention psychosocial factors cardiac rehabilitation
the effects of hemodilution methods in patients undergoing primary debulking gynaecological surgery

Conditions: Ovarian Neoplasm Epithelial

Summary: primary cytoreductive surgery for ovarian cancer is an ideal setting to evaluate endothelial function under anh and ahh, as the procedure is associated with moderately high blood loss. as the technique has not yet been described in this setting, investigators designed a pilot study to evaluate anh and ahh in patients planned to undergo primary cytoreduction during perioperative period, with the intent of proceeding to a randomized trial if results were favorable.

using a computer-generated random number table, patients were randomized to three groups: control group(n=30), anh group(n=30) and ahh group(n=30). patients underwent standard preoperative preparation for cytoreductive surgery according to institutional standards.all patients who underwent a standard anesthesia protocol and similar surgical procedures were considered for the analysis. for this purpose, investigators only included patients who underwent the following interventions: radical hysterectomy, bilateral adnexectomy, one or more bowel resection, peritonectomy, pelvic lymphadenectomy and extended periaortic lymphadenectomy. the patient would be ruled out of the experiment when the participant was accompanied with any kind of serious complications such as wakening delay and drug allergy.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of advanced primary epithelial ovarian 2. no comorbidities nor functional limitations (asa grade ii due to high tumor load) 3. serum hemoglobin (hb) before surgery ≥ 11g/dl 4. hematocrit (hct) ≥ 35% 5. quantity of platelets ≥ 100 × 109 /l exclusion criteria: 1. age \ 65 years 2. body mass index \ 30 kg/m2 3. duration of surgery \<180 min 4. severe cardiovascular disease, liver and kidney disease 5. thromboembolism history

Keywords: acute normovolemic hemodilution (anh) acute hypervolemic hemodilution (ahh) ovarian cancer
predictive value of endometrial cytokines in endometrial implantation in cases of intracytoplasmic sperm injection

Conditions: Infertility

Summary: for all women immediately after ovum retrieval from 80 women undergoing ivf, intra uterine salin flushing will be analyzed using a multiplex immunoassay for soluble regulators of implantation, namely interleukin (il)-1b, tumor necrosis factor (tnf)-a,. in order to detect implantation predictors.

this is a prospective cohort study, performed on 80 women attending obstetrics and gynecology department of benha university hospital for invitro fertilization/intracytoplasmic sperm injection treatment and private ivf centers. none undergoes more than one prior unsuccessful embryo transfer. method of randomization: simple random sample, which is a subset of individuals (a sample) chosen from a larger set (a population). each individual is chosen randomly and entirely by chance, so each individual has the sample probability of being chosen at any stage during the sampling process, and each subset of k individuals has the same probability of being chosen for the sample as any other subset of k individuals (yates et al., 2008). methods: the patients will be subjected to the following: * history. * general examination. * endometrial secretion aspiration. * determination of the cytokine profile. * detection of implantation rate. inclusion criteria: 1. age younger than 37 years. 2. having a regular and proven ovulatory menstrual cycles with a length of 26-35 days. 3. body mass index less than 35 kg/m2. 4. serum follicle stimulating hormone and estradiol were within normal ranges. indications of ivf: tubal pathology, unexplained infertility, and male factor. exclusion criteria: gross uterine pathology. steps of performance: all women having the inclusion criteria were subjected to super ovulation protocols followed by hcg adminstration when the follicles reached 18-20 mm . ovum retrieval were done at 35 hours following hcg injection. five millilitre of salin are injected intrauterine then aspirated after ovum retrieval.endometrial secretions, aspirated immediately after ovum retrieval from 80 women undergoing ivf, will be analyzed using a multiplex immunoassay for soluble regulators of implantation, namely interleukin (il)-1b, tumor necrosis factor (tnf)-a,. in order to detect implantation predictors.

Eligibility criteria:
inclusion criteria: 1. age younger than 37 years. 2. having a regular and proven ovulatory menstrual cycles with a length of 26-35 days. 3. body mass index less than 35 kg/m2. 4. serum follicle stimulating hormone and estradiol were within normal ranges. exclusion criteria: * gross uterine pathology.

Keywords: endometrial -cytokines
effect of scapular stabilization exercises in individuals with adolescent idiopathic scoliosis

Conditions: Adolescent Idiopathic Scoliosis

Summary: idiopathic scoliosis is a three-dimensional deformity of the spine that accounts for approximately 70% of all scoliosis anomalies, and adolescent idiopathic scoliosis (ais) is the most common type. ais not only changes the shape of the trunk, but also the relationships between body parts. considering the close anatomical relationship between the scapula and the rib cage, ais is associated with changes in scapular position and orientation. scapular stabilization exercises; these are exercises that aim to restore the position and orientation of the scapula and the motor control and movement pattern of the muscles, thus providing scapula stability for better shoulder kinematics. there are studies reporting that scapular stabilization exercises should be included in the rehabilitation program of patients with scapular dyskinesia and various shoulder pathologies. however, no study has been found in the literature examining the effects of scapular stabilization exercises on changes in scapular position, shoulder imbalance and curve severity seen in scoliosis. therefore, the aim of the study is to investigate the effect of scapular stabilization exercises applied in addition to schroth exercises used in the treatment of individuals with ais, on scoliosis severity, scapula position and shoulder imbalance.


Eligibility criteria:
inclusion criteria: * diagnosed with adolescent idiopathic scoliosis, * having cobb angle between 10°-30°, * those with main thoracic curvature, * risser stage between 0-3, * volunteer individuals exclusion criteria: * individuals who have had surgery related to the spine and upper extremity, * using a supra-axillary trunk orthosis, * having any systemic or neurological disease
open, randomized, two way crossover 40mg, orally and intravenously

Conditions: GERD

Summary: this study looks at the effect on basal and pentagastrin-stimulated acid output of 40 mg esomeprazole (nexium) administered orally and intravenously as a 15-minute infusion to people with symptoms of gastroesophageal reflux disease (gerd)


Eligibility criteria:
inclusion criteria: 1. heartburn on at least 2 days of the past 7 days prior to screening, with or without a history of ee or a documented diagnosis of gerd within 6 months prior to screening, with or without a history of ee. 2. body mass index (bmi) of ≥18.5 and ≤35 kg/m2. \[bmi will be calculated using the following formula: weight (kg)/height (m)2.\] 3. able to communicate with the investigator and to understand and comply with the requirements of the study. exclusion criteria: 1. history of esophageal, gastric, or duodenal surgery, except for simple closure of an ulcer. 2. history of severe liver disease, including (but not limited to) cirrhosis and acute or chronic hepatitis. 3. any significant "alarm symptoms", within the past 6 months, such as, unintentional weight loss, gastrointestinal bleeding, jaundice or any other sign indicating serious or malignant disease. 4. abnormal lab test results, as indicated in the protocol. 5. other diseases, as indicated in the protocol.

Keywords: gastroesophageal reflux disease (gerd), esomeprazole, nexium
study on the prognostic prediction model of patients with acute intracerebral hemorrhage by artificial intelligence

Conditions: Cerebral Hemorrhage; Prognosis; Artificial Intelligence

Summary: spontaneous intracerebral hemorrhage(sich) is the most lethal and disabling stroke. timely and accurate assessment of patient prognosis could facilitate clinical decision making and stratified management of patients and is important for improving patient clinical prognosis. however, current studies on the prediction of prognosis of patients with sich are limited and only include a single variable, with less precise results and inconvenient clinical application, which may lead to delays in effective patient treatment. our group's previous studies on sich showed that hematoma heterogeneity and the degree of contrast extravasation within the hematoma are closely related to the clinical outcome of patients, but they are difficult to describe quantitatively based on imaging signs. based on this, we propose to use radiomics to quantitatively extract hematoma features from ncct and cta images, combine them with patients' clinical information and laboratory tests, study their relationship with the prognosis of cerebral hemorrhage, and use artificial intelligence to establish a rapid and accurate prognostic prediction model for patients with sich, which is of great significance to guide clinical individualized treatment.


Eligibility criteria:
inclusion criteria: * 1. aged 18-80 years; 2. patients diagnosed with acute cerebral hemorrhage by ct examination; 3. complete non-contrast ct and cta images; 4. the time interval from onset to the first baseline ct and cta examination is less than 6 hours; 5. follow-up data within 3 months; 6. agree and sign a written document. exclusion criteria: * 1. patients with secondary aneurysm hemorrhage; 2. patients with secondary hemorrhage of cerebrovascular malformation; 3. patients with dissecting aneurysm hemorrhage; 4. patients with cerebral infarction hemorrhage transformation; 5. patients lost to follow-up within 3 months; 6. ct or cta images have a heavy artefact.
assessment of fistula closure by otsc clip after bariatric surgery

Conditions: Bariatric Surgery (Sleeve Gastrectomy )

Summary: anastomotic fistula following bariatric surgery are lifethreatening complication with a 37.5% mortality rate. all the modalities for bariatric surgery are involved in this type of complication, but sleeve gastrectomy is the main surgery responsible for the frequency and the severity of the fistula. the management of this complication is still controversial and potentially lethal. the average number of endoscopic sessions was 4 (range 2-11). the closure could be obtained within a mean time of 88 days (range 6-216 days). therefore endoscopic management has to be improved to reduce the duration of the treatment and the number of endoscopic sessions. otsc clips could help to improve the endoscopic management because of a more prehensive, deeper and larger suture area.


Eligibility criteria:
inclusion criteria: * age upper to 18 years * surgery bariatrique typical sleeve * presence of one or two fistulas \< 1 cm, beforehand drained and without sepsis evolutionary * signature of the consent exclusion criteria: * surgery bariatrique other one than sleeve * refusal of the patient of this endoscopic repeated coverage(care) requiring several sessions of endoscopies under ag with hospitalizations * current sepsis * not drained cavity * absence of signed consent