Kornimate/medical-research-clean huggingface dataset:
feasibility and efficacy of assisstive tactile and auditory communicating devices

Conditions: Visual Impairment

Summary: this pilot study will integrate multi-sensor fusion techniques (software) to effectively combine information obtained from the newly embedded infrared, ultrasound, and stereo-camera-based sensor systems (hardware) that are implemented into the vis4ion platform. the core of this technology is based on 4 components: (1) a wearable vest with several distinct range and image sensors embedded. these sensors extract pertinent information about obstacles and the environment, which are conveyed to (2) a haptic interface (belt) that communicates this spatial information to the end-user in real-time via an intuitive, ergonomic and personalized vibrotactile re-display along the torso. (3) a smartphone serves as a connectivity gateway and coordinates the core components through wifi, bluetooth, and/or 4g lte, (4) a headset that contains both binaural, open-ear, bone conduction speakers (leaving the ear canal patent for ambient sounds) and a microphone for oral communication-based voice recognition during use of a virtual personal assistant (vpa). blindfolded-sighted, and blind subjects in a real-world, combined obstacle avoidance / navigation task will serve as an independent measure of overall improvements in the system as well as a roadmap for future avenues to enhance performance. further, a prospective, randomized crossover, controlled, non-blinded phase will be conducted in thailand as part of this study to compare and evaluate effectiveness of the wearable vest for increasing navigation and quality of life.

investigators will try to develop algorithms that will recognize multiple objects and persons in real-time (enhanced scene interpretation for multi-object identification). and based on that, human-centered simulation trials and experiments for feasibility and efficacy of the platform's tactile and auditory 'communication' outputs will be conducted. finally auditory and tactile 'prompts' (system output) based on the end user's immediate needs based on initial testing results, will be integrated into the platform. additional activities will occur at the thailand site. in the second phase, an improved system will be tested in an extended-use experiment, detecting for health-related changes in our participants (increased mobility and qol). the study team will further test the generalizability of the new mapping technology in a more challenging environment, testing system performance using metrics, comparing results between current and previous systems.

Eligibility criteria:
inclusion criteria: * people with visual impairments of all different levels and etiologies. exclusion criteria: * significant cognitive dysfunction (score \<24 on folsteins' mini mental status examination) * previous neurological illness, complicated medical condition; * significant mobility restrictions; people using walkers and wheelchairs * pregnancy

Keywords: visual impairment
quantitative mri of glenohumeral cartilage & labrum in shoulder instability

Conditions: Instability, Joint; Shoulder Dislocation; Shoulder Injuries; Shoulder Subluxation; Anterior Shoulder Instability; Glenoid; Dislocation

Summary: the purpose of this study is to assess cartilage strain and contact areas following glenohumeral instability compared to healthy individuals.

the purpose of this study is to assess cartilage strain and contact areas following glenohumeral instability compared to healthy individuals. this is a prospective longitudinal cohort study to investigate cartilage strain and labral injury utilizing advance mri techniques. patients with shoulder instability will be studied at baseline (after injury and prior to surgical treatment) with glenohumeral cartilage strain mri protocol, pre and post exercise. patient reported outcomes including western ontario shoulder instability index (wosi), american shoulder and elbow surgeon (ases) score, and promis physical function and pain scores, will also be evaluated. data from this study will be compared to a previous study involving healthy controls that underwent the same exercises and imaging.

Eligibility criteria:
inclusion criteria: * males and females ≥ 18 years old and ≤ 50 years old * acute injury involving anterior (front) shoulder dislocation * willingness to undergo arthroscopic shoulder stabilization * willingness to participant in standard rehabilitation exclusion criteria: * moderate to severe osteoarthritis prior to surgery * will undergo bony augmentation to glenoid or humerus in addition to shoulder stabilization * unable to undergo standard pre and post-injury/operative rehabilitation * history of inflammatory arthritis * previous surgery of the injured shoulder

Keywords: instability shoulder dislocation glenoid acute arthroscopy
oct-guided lalak for kcn

Conditions: Corneal Opacity; Keratoconus

Summary: the purpose of this study is to determine if a new procedure, called laser-assisted lamellar anterior keratoplasty (lalak), can achieve the same level of vision with a lower risk of potential complications after surgery compared to another corneal transplant procedure. the current procedure is called intralase-enabled keratoplasty (iek) and replaces the entire cornea. the lalak procedure involves transplanting only the top layers of the cornea instead of the entire cornea. only one eye will have this experimental procedure performed. if both eyes need to have surgery your doctor will help you decide on the best non-study option for your other eye.

corneal transplantation (keratoplasty) is the most common organ transplant, with 42,606 procedures in the u.s. in 2009. many surgeons are moving away from full thickness corneal transplantation, also called penetrating keratoplasty (pk), because of risks involving rejection, irregular astigmatism and wound dehiscence. they are moving towards partial thickness (lamellar) transplantations of either the anterior or posterior (endothelial) layers, which can reduce these risks. the femtosecond laser has been used to create excellent tongue-in-groove junctions between the graft and host in full thickness pk.1 this technique, called iek (intralase-enabled keratoplasty), has now become a standard surgical procedure. the tongue-in-groove junction achieved at the circumferential edge of the graft and host leads to a continuous smooth anterior surface and strong wound healing. the new technique is called dovetail lalak. in this technique, the femtosecond laser is used to create a 31% anterior lamellar graft with dove tailed side cuts. it is also used to create a shallow anterior lamellar dissection and beveled side cuts on the recipient cornea to match with the dovetail graft. in the new technique, the depth of the graft and donor dissections will be guided by oct measurements. the proposed trial will test if the new technique can reproducibly achieve good visual outcomes without the risk of rejection. the outcome of the lalak procedure will be compared to that of iek.

Eligibility criteria:
inclusion criteria: * eyes with keratoconus that cannot be adequately or safely corrected with spectacles, contact lens or excimer laser surface ablation. the cornea must have healthy endothelium (endothelial cell density \> 1,500/mm2). exclusion criteria: 1. preoperative corneal thickness less than 400 microns. 2. corneal edema 3. central guttata 4. inability to give informed consent. 5. inability to maintain stable fixation for oct imaging. 6. inability to commit to required visits to complete the study. 7. eyes with concurrent cataract, retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery. 8. patients with severe collagen vascular diseases or ocular surface disorders

Keywords: keratoconus corneal opacity keratoplasty
postoperative pulpal complications in posterior resin composite restorations without glass-ionomer cement lining

Conditions: Dental Caries

Summary: the purpose of this study is to observe the effects of glass-ionomer cement (gic) lining on risk of pulpal complications in deep occlusal cavities with resin-based restorations.

fifty three patients aged 18-30 years who had one or two deep occlusal carious lesions (≥ 3 mm in depth) in molars were recruited. dental caries was removed and the prepared cavity was restored with resin composite using one of two restorative procedures: (1) without gic lining; (2) with (resin-modified) gic lining. restored teeth were evaluated for any pulpal complications (subjective symptoms, objective signs or loss of tooth vitality) at one month (baseline), one year and two years after restoration.

Eligibility criteria:
inclusion criteria: * deep dental caries on occlusal surfaces of molar teeth exclusion criteria: * shallow and moderate-depth caries * caries exposed pulp

Keywords: deep occlusal caries restored with resin composite on pit and fissure surface penetrating into dentin
healthy lifestyles for mentally ill people who have experienced weight gain from their antipsychotic medications - 2

Conditions: Diabetes; Obesity; Weight Gain

Summary: this program aims to help veterans who take antipsychotic medications lose weight. we use a program based on the american diabetes association's "diabetes prevention program," and we have modified it to fit the lifestyles of people with mental illness. all participants are educated about nutrition and cutting down fat intake, how and when to exercise, and the causes of diabetes and how to prevent it. participants must be veterans who live within one hour of the long beach, west los angeles, sepulveda, or west los angeles va hospitals.


Eligibility criteria:
inclusion criteria: * must be a veteran * diagnosis of psychotic disorders, schizophrenia, schizoaffective disorder and bipolar illness * age 18-70 * clinically determined to require ongoing treatment with second generation antipsychotics (sga) such as olanzapine, risperidone, quetiapine, ziprasidone, aripiprazole, clozapine * experienced weight gain since treatment with sga's * inpatient or outpatient at long beach, west los angeles, sepulveda, or downtown va * competent to sign informed consent exclusion criteria: * have recently been diagnosed with schizophrenia (less than 1 year) * are pregnant or breast feeding a baby * have a medically unstable condition

Keywords: antipsychotic bipolar diabetes mental illness nutrition obesity schizoaffective schizophrenia weight gain weight loss
interaction between antihypertensives and non-steroidal anti-inflammatory drugs (nsaids)

Conditions: Hypertension

Summary: nsaids may increase blood pressure and blunt the effects of many antihypertensives. members of these drug classes differ in their propensity to such an interaction.

to compare prospectively the effects of piroxicam, ibuprofen and acetaminophen on blood pressure control in hypertensive patients with osteoarthritis.

Eligibility criteria:
inclusion criteria: * treated hypertensives of either gender aged between 55 and 76 years * about 50% with concomitant osteoarthritis of the hip or knee exclusion criteria: * normotensive persons or untreated hypertensives * individuals outside the age limits * general exclusion criteria (e.g. uncooperative persons, advanced malignancies, participants in other studies)

Keywords: antihypertensive drugs non-steroidal anti-inflammatory drugs interaction family practice arterial blood pressure
efficacy and safety of ofatumumab compared to placebo in patients with relapsing multiple sclerosis followed by extended treatment with open-label ofatumumab

Conditions: Relapsing Multiple Sclerosis

Summary: the study provided efficacy, safety, and pharmacokinetics (pk) data for patients with relapsing multiple sclerosis (rms) in japan and the other countries

this study had 2 parts: a controlled core and an open-label extension. * core part: a 24-week, randomized, double-blind, placebo controlled, parallel-group, multicenter study evaluated the efficacy, safety and tolerability and pk of ofatumumab in patients with rms. * extension part: the core part was followed by an extension part in which all patients received open-label ofatumumab. in the extension part, patients were treated for at least 24 weeks and no longer than 48 weeks. sixty-four patients were randomized in a 2:1 ratio to ofatumumab or placebo in the core part; half of the study patients were from japan and the other half from the other countries.

Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis (ms) * relapsing ms (rms) * at least 1 appearance of a new neurological abnormality or worsening of pre-existing neurological abnormality during the previous 2 years prior to screening and an mri activity (gd-enhancing t1 lesions or new or enlarging t2 lesions) in brain during the previous 1 year prior to randomization * edss score of 0 to 5.5 exclusion criteria: * primary progressive ms or spms without disease activity * patients with an active chronic disease of the immune system other than ms * patients at risk of developing or having reactivation of hepatitis * patients with active systemic infections or with neurological findings consistent with pml

Keywords: double-blind placebo controlled ofatumumab relapsing multiple sclerosis japanese patients ms rms adult omb157
a retrospective real world analysis of sutent in patients with metastatic renal cell carcinoma in community and academic centers to assess the impact of dose variation on duration of response and overall survival

Conditions: Metastatic Renal Cell Carcinoma

Summary: this is a retrospective, non-interventional study which looks at the cohort of renal cell carcinoma patients in a real life clinical setting and analyses into factors why these patients have been surviving for as long as 3-5 years unlike clinical study where the survival is around 2 years. the factors which will be analysed include patient characteristics, dosage and adverse event management and tries to correlate these factors with survival.

a single cohort of 200 patients who are diagnosed with metastatic renal cell carcinoma prior to 1st jan 2012, and are seen by the medical oncologist at the centers involved with biogrid and its affiliated registries. patients will be identified from the first date of their consultation with the medical oncologist and captured in the electronic database. consent to use datasets has already been obtained from participating research institutes and hospitals irb/ethics committees

Eligibility criteria:
inclusion criteria: * age \>18 * male or female * metastatic renal cell cancer * first presentation with metastatic disease prior to 1st jan 2012 since 2006, i.e. between 1st jan 2006 to 31st dec 2011 exclusion criteria: * no referral to medical oncologist * no record available in electronic database
the clinical utility of extracorporeal shock wave therapy on hand burns

Conditions: Hand Burn

Summary: no study has investigated the effect of extracorporeal shock wave therapy (eswt) on hand function and hypertrophic scar characteristics. to investigate eswt effects on burned hands, the investigators compare the results of eswt combined with manual therapy group to the results of matched conventional(con) rehabilitation combined with manual therapy group.

hands are the most frequent injury sites caused by burn, and appropriate rehabilitation is essential to ensure that good functional recovery is achieved. in burn patients, the wound healing process may lead to a fibrotic hypertrophic scar, which is raised, red, inflexible and responsible functional and cosmetic impairments. this randomized, controlled trial involved 40 patients with burns and dominant right-hand function impairment. patients were randomized into a eswt or a con group. each intervention was applied to the affected hand for 4 weeks once per week. hand function was evaluated using the jebsen-taylor hand function test (jtt), grasp and pinch power test, and michigan hand outcomes questionnaire (mhq). these assessments were evaluated pre-intervention and 4 weeks post-intervention.

Eligibility criteria:
inclusion criteria: * a deep partial-thickness (second-degree) burn or a full thickness (third-degree) burn to their hands * less than 6 months since the onset of the burn injury exclusion criteria: * fourth-degree burns(involving muscles, tendons, and bone injuries)\\ * musculoskeletal diseases(fracture, amputation, rheumatoid arthritis, and degenerative joint diseases) in the burned hands * neurological diseases(such as peripheral nerve disorders) * preexisting physical and psychologic disability (severe aphasia and cognitive impairment that could influence the intervention) * severe pain impeding hand rehabilitation
clinical study of taurine combined with sintilimab and chemotherapy for treatment of advanced gastric cancer

Conditions: Gastric Cancer

Summary: this project aims to evaluate the efficacy and safety of oral taurine supplementation combined with pd-1 inhibitor (sintilimab) and chemotherapy in inducing systemic cd8+ t cell responses and achieving improved gastric cancer patient outcomes than with sintilimab and chemotherapy alone.


Eligibility criteria:
inclusion criteria: 1. age 18 or older, no gender limitation; 2. pathologically confirmed gastric cancer or adenocarcinoma of the gastroesophageal junction, local lesions cannot be radically resected or metastatic gastric cancer; 3. expected survival of ≥ 3 months; 4. eastern cooperative oncology group (ecog) performance status score of 0 or 1; 5. at least one measurable lesion outside the stomach (recist 1.1); 6. patients informed about the purpose and course of the study and provided a written consent to participate. exclusion criteria: 1. use of taurine agent within 1 month prior to randomization on this study; 2. patients received prior systemic therapy for gastric cancer; 3. patients with operable gastric cancer; 4. patients with positive her-2 and willing to receive herceptin treatment; 5. patients with gastrointestinal obstruction or active bleeding in the gastrointestinal tract, as well as perforation and dysphagia; 6. patients with active autoimmune disease that has required systemic treatment in past 2 years; 7. patients diagnosed as immunodeficiency or receiving systemic steroid therapy or any other form of immunosuppressive therapy; 8. patients with severe heart, lung, liver, kidney, endocrine, hematopoietic system or psychiatric diseases were considered not suitable for the study group; 9. patients with other medical conditions that interfere with the trial and are deemed unsuitable for inclusion in the trial by the investigator; 10. other conditions that the investigator thinks are not suitable to participate in this clinical trial.
an optical assay system for intra operative assessment of tumor margins in patients

Conditions: Breast Cancer

Summary: our objective is to develop a novel optical assay system for intra operative assessment of tumor margins in partial mastectomy or mastectomy specimens. our group has previously shown that optical techniques can effectively discriminate between malignant and non-malignant breast tissues. we have also shown that data collection and processing from a single point on the tissue specimen requires less than 5 seconds. in addition, the technique is easily adaptable to provide sensing depths that are required for breast margin assessment. the goal of the work proposed in this protocol is to test the sensitivity and specificity of an optical assay system developed by our group, for intra operative assessment of breast tumor margins.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of breast cancer exclusion criteria:

Keywords: partial mastectomy lumpectomy mastectomy
impact of pre-operative penicillin allergy evaluation on surgical prophylaxis

Conditions: Penicillin Allergy; Surgical Prophylaxis

Summary: use of first-line pre-operative antibiotic prophylaxis is the most effective measure to optimize perioperative outcomes. however, this is often not achieved due to unsubstantiated penicillin allergy labels. penicillin allergy evaluation, when incorporated into routine pre-operative assessment, is potentially effective in optimizing choice of surgical prophylaxis. despite the encouraging data mentioned above, there is a lack of randomized trials or local data to support this practice.


Eligibility criteria:
inclusion criteria: * age 18 years or above * planned for clean or clean-contaminated elective surgeries * labelled allergy to penicillin group antibiotics on electronic patient record (epr) exclusion criteria: * multiple antibiotic allergy * history of severe cutaneous adverse reactions or other severe non-ige-mediated hypersensitivity (e.g. haemolytic anaemia, organ dysfunction, serum sickness) due to beta-lactam antibiotics * on systemic immunosuppressants * pregnancy * active or uncontrolled chronic urticaria * mentally incompetent for informed consent
impact of covid-19 on psychological status in case of ivf interrupted or postponed

Conditions: Infertility, Female; ART; IVF; COVID-19

Summary: infertility is a severely distressing experience for many couples. depression and anxiety are psychological disorders associated with infertility, and they may worsen during infertility treatments. this study times to understand the changes in the psychological status of infertile patients who had in vitro fertilization (ivf) treatment interrupted or postponed because of the covid-19 pandemic.


Eligibility criteria:
inclusion criteria: * patients with ivf treatment interrupted or delayed during covid-19 pandemic * patients with signed informed consent * patients with more than 18 years exclusion criteria: * patients with already diagnosed psychiatric disorders
effect of botulinum toxin type a associated with physical therapy on children with spastic cerebral palsy

Conditions: Cerebral Palsy, Spastic; Physical Therapy; Botulinum Toxin

Summary: purpose: the aim of this study was investigate the effects of botulinum toxin type a (bont-a) associated with physical therapy on the functional capacity of children with spastic cerebral palsy (cp). material and methods: twenty-four children with spastic cp were concealed and randomly assigned to the experimental group (eg) consisting of 12 patients treated with bont-a and physical therapy and control with 12 patients treated only with physical therapy. all participants were assessed through motor and functional scales (gmfm-88, ashworth, berg balance scale, tug test and pediatric evaluation of disability inventory) at three different times: before and after 30 days of treatment as well as 3 months after the end of treatment.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of spastic cerebral palsy * clinical diagnosis of dynamic equine feet exclusion criteria: * use of phenol in the last 12 months * neurological blocks in the last 6 months * clinical diagnosis of structured orthopedic deformities with surgical indications
efficacy of nucleo cmp forte in traumatic brain injury in pediatrics

Conditions: Brain Injuries

Summary: efficacy of nucleo cmp forte in traumatic brain injury in pediatrics

the study aims to study the efficacy of nucleo cmp forte in traumatic brain injury in pediatrics

Eligibility criteria:
inclusion criteria: * children with traumatic brain injury: moderate and severe. exclusion criteria: * underlying cns disorders,