Kornimate/medical-research-clean huggingface dataset:
effect of exercise on vessel diameter in hemodialysis patients

Conditions: Chronic Kidney Diseases

Summary: in this study, 100 hemodialysis patients aged between 18-65 were examined. participants were randomly divided into two groups: the exercise group and the control group. the exercise group performed moderate-intensity aerobic exercises for 30 minutes three times a week during hemodialysis sessions. additionally, they engaged in walking exercises for 30 minutes three times a week outside of hemodialysis sessions, maintaining their heart rate between 50-60%. the exercise group also performed isolated exercises to expand wrist vessels 2-3 days a week outside of hemodialysis sessions. the vessel diameters of the patients were measured by ultrasound at the beginning and after 12 weeks.

background: as it is known, many negative situations occur in ckd patients on hemodialysis. one of these is the problems seen in the vascular access. the prevention and management of vascular access complications may benefit from exercise the purpose of this study is to investigate the effect of exercise on the vessel diameter in hd patients. methods: present study we were included 100 hemodialysis patients between the ages of 18-65.participants were randomly divided into two groups: the exercise group and the control group. the exercise group performed moderate-intensity aerobic exercise on a stationary bicycle ergometer for 30 minutes during hemodialysis sessions, three days a week over 12 weeks. additionally, the exercise group engaged in walking exercise for 30 minutes, three days a week outside of hemodialysis sessions, maintaining the heart rate between 50-60%. the exercise group also performed isolated exercises to expand wrist vessels, including wrist and elbow flexion, extension, and rotation, repeated 10 times, 2-3 days a week outside of hemodialysis sessions. and the vessel diameters of patients were measured by ultrasound at the beginning and after 12 weeks.

Eligibility criteria:
inclusion criteria: * being between 18-65 years of age * undergoing hemodialysis treatment for at least 6 months * using arteriovenous fistula, arteriovenous graft, or permanent catheter as the vascular access type. * having no orthopedic, neurological, cardiac, or respiratory diseases that could hinder exercise * willingness to participate in exercise. exclusion criteria: * access complications such as acute or chronic infections, inflammation, bleeding, aneurysms, stenosis, thrombosis, or any condition that hindered exercise, * acute or chronic cardiovascular complications such as cardiac arrhythmias, ischemia, heart failure. * hypertension, or hypotension that hindered exercise. * acute or chronic musculoskeletal injuries, pain, inflammation, or deformities that hindered exercise. * refusal to participate in exercise. were excluded from the study.
development of a diagnostic kit for flt3-itd in acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: flt3 overexpression in acute myeloid leukemia (aml) is often caused by mutations in this gene. these mutations cause constitutive phosphorylation of flt3 proteins leading to increased proliferation and survival, decreased apoptosis and resistance to chemotherapeutic agents in aml cells. there are two major types of flt3 mutations- internal tandem duplication (itd) and point mutation at 835th amino residue. amls with flt3 mutations have worse prognosis and are often resistant to conventional chemotherapy. several small molecule compounds targeting flt3 have been in the market or in clinical trials. therefore, identification of these mutations at the time of diagnosis will provide a better prognostic prediction, might guide the treatment selection and follow-up strategies. in this study, the investigators will develop a sensitive molecular assay to detect flt3 mutations for future clinical application. the investigators will collect 100 aml samples with at least 20 samples with known flt3 mutations. the investigators will compare this assay with commonly used methods and standardize the procedure to meet the requirement of clinical pathology laboratory with reasonable cost.


Eligibility criteria:
inclusion criteria: * patients with confirmed diagnosis of acute myeloid leukemia exclusion criteria: * non

Keywords: flt3-itd acute myeloid leukemia flt3 d835
a prospective non-interventional observational study to observe long-term treatment and outcomes in pulmonary arterial hypertension (pah) patients

Conditions: Pulmonary Arterial Hypertension

Summary: the goal of this observational study is to learn about the long-term development and outcomes of different treatment patterns of patients who initially participated in the tripletre study. the primary objective of this non-interventional follow-up study is to assess the long-term real-world clinical outcomes, including disease progression and survival rates, in patients who initially participated in and completed the randomized tripletre trial. planned observation duration per patient is a minimum of 3 years.


Eligibility criteria:
inclusion criteria: 1. patients previously participating in the randomized tripletre trial who are able and willing to provide a signed informed consent for study participation in nis exclusion criteria: 1. lost to follow-up patients of tripletre study 2. patients who discontinued all medicinal pah treatments (e.g. after successful lung transplantation) 3. patients who withdrew from the initial tripletre trial due to significant non-compliance with trial requirements (not adhering to therapy, not coming to hospital visits)
message offering free round trip ride-share ride to pharmacy

Conditions: COVID-19

Summary: this experiment is part of a megastudy with a total of ten experimental conditions and a holdout control condition to which patients will be randomly assigned. the focal comparison in this experiment is between a message encouraging vaccination that provides patients with a free round trip ride-share ride to and from any pharmacy near them and a control message telling patients that an updated covid booster vaccine is waiting for them.


Eligibility criteria:
exclusion criteria: 1. the patient unsubscribed from texts before the send date and time of the patient's sms/mms message 2. the patient received a bivalent covid booster before the send date and time of the patient's sms/mms message.

Keywords: covid-19 behavioral science interventions vaccination promotion
efficacy of atenativ in patients with congenital antithrombin deficiency undergoing surgery or delivery

Conditions: Congenital Antithrombin Deficiency

Summary: the goal of this study is to assess the incidence of the composite of thrombotic events (tes) and thromboembolic events (tees) in patients with congenital antithrombin deficiency under when they receive atenativ for surgical procedures or parturition.


Eligibility criteria:
inclusion criteria: 1. adult male or female patients ≥18 and ≤80 years of age. solely in the us, 4 male or female patients between ≥12 and \<17 years of age will be enrolled into the pk phase, and subsequently in the treatment phase, if applicable 2. documented congenital antithrombin deficiency, defined by plasma activity level of antithrombin ≤60% from medical history 3. personal or family history of tes or tees (except for pk patients) 4. for the treatment phase: either a) non-pregnant surgical patients scheduled for elective surgical procedure(s) known to be associated with a high risk for occurrence of tes or tees, or b) pregnant patients of at least 27 weeks gestational age who are scheduled for caesarean section or delivery 5. for female patients of childbearing potential entering the pk phase who are not known to be pregnant, and for female surgical patients of childbearing potential entering the treatment phase for any procedure other than caesarean section or delivery, a negative urine pregnancy test at screening and at baseline 6. patient has provided informed consent exclusion criteria: 1. requires emergency surgery or emergency caesarean section 2. has undergone surgery within the last 6 weeks 3. history or suspicion of another hereditary thrombophilic disorder other than antithrombin deficiency (e.g., activated protein c \[apc\] resistance/factor v leiden, protein s or c deficiency, prothrombin gene mutation \[g20210a\], or acquired \[lupus anticoagulant\] thrombophilic disorder) 4. malignancies, renal failure (patients on renal replacement therapy), or severe liver disease (aspartate aminotransferase \[asat\] \>5 times the upper limit of normal) 5. body mass index \>40 kg/m2 (for non-pregnant patients, only) 6. known hypersensitivity or allergic reaction to antithrombin or any of the excipients in atenativ 7. history of anaphylactic reaction(s) to blood or blood components 8. refusal to receive transfusion of blood-derived products 9. administration of any antithrombin concentrate or antithrombin-containing blood product within 14 days of either of the two phases of the study 10. prior diagnosis of heparin-induced thrombocytopenia 11. te or tee within the last 6 months 12. female patients who are nursing at the time of screening\* 13. have participated in another investigational study within the last 30 days 14. persons dependent on the sponsor, the investigator or the centre of investigation 15. persons placed in an institution by administrative or judicial order * criterion does not include female patients who plan to breastfeed after giving birth
study of fecal bacteria in early diagnosis of colorectal cancer

Conditions: Colorectal Neoplasms

Summary: the aim of the study is to identify and verify one or more gut bacteria of which the abundance in feces may help to early diagnosis colorectal cancer.

gut microbiota is closely related to human gut neoplasm. according to recent statistics, the abundance of fn (fusobacterium nucleatum) is connected with the development and progression of crcs (colorectal cancers). subsequent research shows identifying multiple microbial-specific genes in human feces using qpcr (quantitative polymerase chain reaction) may help diagnosis of early stage colorectal cancer. currently little is known about the relationship between single abundance of specific gut microbiota and colorectal cancer in different stage. moreover, finding early-stage crcs is still of great challenge partially due to precancerous diseases like colorectal adenoma which remain difficult to differentiate from early-stage crc under endoscope. conventional clinic methods predicting crcs largely depend on serum cea (serum carcino embryonic antigen) and ob(fecal occult blood test), which lack of adequate sensitivity and specificity especially in early stage crcs. the investigators' work focuses on the abundance of gut microbiota in feces from people with colon neoplasm and its comparison with classical indicators such as cea and ob, aiming to reveal and testify its potential role on assisting diagnosis of crcs in different stage as a none-invasive cost-effective method.

Eligibility criteria:
inclusion criteria: * patients age from 40 to 85 years old * patients with endoscopic or pathological confirmed healthy, adenoma, inflammation, early or late stage of colorectal cancer * patients with valid cea(carcino embryonic antigen) and ob(occult blood) test result in 1 year before or after the coloscopy or surgery exclusion criteria: * patients with history of colorectal cancer * patients with long term use of antibiotics or probiotics * patients with uncontrolled diabetes, hypertension or hepatitis * patients with a history of subtotal gastrectomy or partial bowel resection * patients who are not able to cooperate * patients with medical conditions who are not appropriate to participate the study * patients who are taking aspirin, nsaids (nonsteroidal antiinflammatory drugs), cox2(cyclo-oxygen-ase 2) inhibitors.

Keywords: gut microbiota
efficacy of combination therapies on neck pain & muscle tenderness in patients with upper trapezius mtrps

Conditions: Myofascial Trigger Point Pain

Summary: myofascial pain syndrome thought to be the main cause of neck pain and shoulder muscle tenderness in the working population is characterized by myofascial trigger points (mtrps). this study aimed to examine the immediate and short-term effect of the combination of two therapeutic techniques for improving neck pain and muscle tenderness in patients with upper trapezius myofascial trigger points.

purpose: myofascial pain syndrome, thought to be the main cause of neck pain and shoulder muscle tenderness in the working population, is characterized by myofascial trigger points (mtrps). this study aimed to examine the immediate and short-term effect of the combination of two therapeutic techniques for improving neck pain and muscle tenderness in male patients with upper trapezius active mtrps. methods: this was a pretest-posttest single-blinded randomized controlled trial. sixty male subjects with mechanical neck pain due to upper trapezius active mtrps were recruited and randomly allocated into group a, which received muscle energy technique (met) and ischemic compression technique (ict)along with conventional intervention; group b, which received all the interventions of group a except ict; and group c, which received conventional treatment only. baseline (pr), immediate post-intervention (po), and 2-week follow-up (fo) measurements were made for all variables. pain intensity and pressure pain threshold (ppt)were assessed by a visual analog scale (vas) and pressure threshold meter, respectively. all three groups received their defined intervention plans only. repeated-measures analysis of variance was used to perform intra- inter-group analyses. cohen's d test was used to assess the effect size of the applied interventions within the groups.

Eligibility criteria:
inclusion criteria: * male subject diagnosed with non-specific neck pain and muscle tenderness over the upper trapezius muscle due to an active mtrp * age19-38 years * presence of a maximum of 1-2active mtrps in a unilateral upper trapezius muscle the number of trps in upper trapezius is not limited to two; it may be one or may be more than two (satellite trps) also. however, due to time constraints of the study sessions allowed for treatment of up to 2 active mtrps only. exclusion criteria: * diagnosed with fibromyalgia syndrome according to the american college of rheumatology criteria; * had active mtrps in the bilateral upper trapezius muscles * had a history of whiplash injury or cervical spine surgery * were diagnosed with cervical radiculopathy or myelopathy determined by their primary health care physician * had accepted myofascial pain therapy within the 1 month before the study * showed poor cooperation.

Keywords: neck pain upper trapezius muscle myofascial trigger points muscle tenderness pain pressure threshold
the ease-it ct registry

Conditions: Transcatheter Aortic Valve Implantation (TAVI)

Summary: ica is not always required for a pre-tavi workup of octogenarians and can be substituted by cta resulting in a streamlined pre-procedural workup of patients without compromising patient safety.

patients undergoing tavi require routine pre-procedural assessment of cad (coronary artery disease). ica (invasive coronary angiography) is the gold standard in patients with high pre-test probability. it is associated, however, with procedural risk, radiation and cost. cta (computed tomography angiography) currently has limited use for the evaluation of cad in pts with severe symptomatic as (aortic stenosis) - medications required such as beta blockers and nitroglycerine, are frequently not well tolerated by pts. but as tavi is increasingly being performed in patients with modest pre-test probabilities for obstructive cad or a lack of implications thereof (pts. ≥75 yrs), the use of cta may become more appealing.

Eligibility criteria:
inclusion criteria: investigational cta-only cohort * consecutive adult patients ≥ 75 years * consecutive patients with severe as (symptomatic or asymptomatic) with a guideline-based indication to undergo implantation of a transcatheter heart valve of the sapien family * ability to undergo cta * patient is scheduled to undergo a 30 day and 3 months follow-up cta+ica control cohort * consecutive adult patients ≥ 75 years * consecutive patients underwent implantation of a transcatheter heart valve of the sapien family because of severe aortic stenosis * ability to undergo cta and ica exclusion criteria: investigational cta-only cohort * patients with already diagnosed proximal stenosis of the left anterior descending artery (lad) or the left main coronary artery (lm) ≥50% * any prior coronary revascularization / prior aortic valve replacement * life expectancy below 12 months * lack of informed consent / data protection statement cta+ica control cohort * patients diagnosed with proximal stenosis of the left anterior descending artery (lad) or the left main coronary artery (lm) ≥50% already at baseline * any prior coronary revascularization / prior aortic valve replacement * life expectancy below 12 months * lack of informed consent / data protection statement

Keywords: tavi transcatheter aortic valve implantation severe aortic stenosis sas computed tomography angiography cta invasive coronary angiography ica coronary artery disease cad
prospective analysis of circulating nucleosomes in patients receiving a first line treatment for a non-hodgkin lymphoma

Conditions: Follicular Lymphoma; Diffuse Large B-Cell Lymphoma

Summary: the goal of this study is to prospectively follow the level of circulating nucleosomes in patients treated for a non-hodgkin lymphoma and determine whether it correlates with the clinical response.


Eligibility criteria:
inclusion criteria: * histologically proven diagnosis of diffuse large b cell lymphoma or follicular lymphoma, according to the who 2016 classification, requiring a first line of treatment with a rchop 21 regimen * agreement to participate after receiving oral and written information on the study exclusion criteria: * history of previous treatment for lymphoma (excluding localized low dose radiotherapy in the case of follicular lymphoma) * treatment with a chemotherapy regimen different from rchop21
dilapan-s/dilasoft e-registry in induction of labor

Conditions: Labour Onset and Length Abnormalities; Labor; Forced or Induced, Affecting Fetus or Newborn

Summary: international observational e-registry on the use of dilapan-s® osmotic dilator / dilasoft® osmotic dilator for cervical ripening prior to labour induction.

international observational e-registry to monitor current common clinical practice of use of dilapan-s / dilasoft for cervical ripening and following procedures of labour induction with the main focus on the duration of induced labor procedure .

Eligibility criteria:
inclusion criteria: * indication for induction of labor * unfavourable cervix exclusion criteria: * presence of overt genital tract infection

Keywords: cervical dilatation
oxygen therapy during acute respiratory failure in immuno-compromised patients

Conditions: Acute Respiratory Failure; Immunocompromised Host; High Flow Oxygen Cannula

Summary: in immunocompromised patients, acute respiratory failure (arf) is associated with a high case-fatality, particularly when invasive mechanical ventilation (mv) is required. in the most hypoxemic patients, oxygen administration through high flow nasal cannula (hfnc) has been reported as an alternative to the venturi mask. the aim of this study is to compare hfnc and venturi mask on early respiratory deterioration and patient's comfort in that setting. the investigators planned a prospective randomized study in 4 intensive care units (icus). as respiratory deterioration occurs early after icu admission, patients are randomized to receive two hours of oxygen therapy either through hfnc or venturi mask. the primary endpoint is defined as the need for invasive or noninvasive mv in the 2-hour period. secondary endpoints include comfort, dyspnea and thirst.


Eligibility criteria:
inclusion criteria: * age over 18 years. * admission to icu for arf. arf was defined with the need of oxygen over 6l/min to maintain spo2 over 95% or symptom of respiratory distress (intercostal recession or tachypnea \>30/min or dyspnea at rest). * immunosuppression. immunosuppressed conditions were solid tumor, hematological malignancy, steroid treatment or other immunosuppressive treatment, or hiv infection. exclusion criteria: * hypercapnia (above 47 mmhg) * chronic respiratory failure * previous mechanical ventilation in the days before admission * need of immediate niv or intubation * refusal * pregnancy
effect of pilates on postural control and balance in children with down's syndrome

Conditions: Down Syndrome

Summary: down's syndrome (ds) is a genetic condition characterized by the presence of an extra chromosome 21, leading to various clinical symptoms. individuals with ds often experience challenges in balance, posture, and motor skills, which can impact their daily activities. pilates activities focus on the concept of control of muscles. pilates increases trunk flexibility, abdominal and core strength and endurance, and deep core muscle activation hence improving balance and posture.

the study will be randomized controlled trial used to evaluate the effectiveness of pilates on posture and balance in children with down's syndrome. subjects with down's syndrome meeting the pre-detremined inclusion and exclusion criteria will be divided into two groups using non-probability sampling technique. assessment will be done using pediatric balance scale(pbs) and timed up and go test (tug).). control group will receive regular physical therapy with balance training and experimental group will receive regular physical therapy+ pilates.

Eligibility criteria:
inclusion criteria: * down's syndrome children with age between 6 and 12 years. * the ability to execute required motor skill proficiency and executive function tests. * the capacity to walk and stand by oneself exclusion criteria: * • children who are not able to comprehend commands. * associated cardiovascular and orthopedic condition. * loss of functional hearing and vision or a related respiratory disease. * history of traumatic injury * history of previous surgery * inability of parents to understand the procedure and their unwillingness to participate

Keywords: balance contrology down syndrome pilates pediatric balance scale