Kornimate/medical-research-clean huggingface dataset:
teen video study to reduce risky driving and sexual behavior in adolescents

Conditions: Pregnancy; Sexually Transmitted Infections; Automobile Accidents

Summary: the purpose of this study is to measure the effects of an interactive video on adolescent risky behaviors and outcomes, with one video intended to reduce teen pregnancies and the other intended to reduce automobile accidents.

motor vehicle crashes cause one-third of teenage deaths and many serious injuries. teen drivers ages 16 to 19 are four times more likely than older drivers to crash. death and injuries could be reduced with a change in behaviors that include improved visual and attention skills while driving, more seat belt use, appropriate speed control, and not combining drinking or texting with driving. sexually transmitted infections (stis) and unplanned pregnancies are particularly common among adolescents. the u.s. adolescent birthrate is by far the highest among industrialized nations. these problems can be decreased by less sexual activity and better protection. this study uses a randomized controlled trial to measure how well interactive video interventions can reduce these common risks to adolescents. adolescent females will be invited to participate if they are currently seeking care at a participating clinic. they will answer survey questions about their driving and sexual behaviors, and then a computer will determine whether they will be given a video about driving or a video about sexual behavior. participants will have unlimited access to their video, which they can watch at their clinic or from any internet-enabled computer, and will be followed for 6 months.

Eligibility criteria:
inclusion criteria: * patient at participating healthcare facility * unmarried at time of enrollment * not pregnant at time of enrollment * available for contact over ensuing 6 months exclusion criteria: * apparent or stated inability to comprehend consent or assent form (e.g., language barrier or cognitive ability) * no ability to provide at least 2 methods of contact * married or pregnant at time of enrollment

Keywords: pregnancy prevention, condom use, self efficacy
comparison of the immediate effects of manipulation on the autonomic nervous system

Conditions: Vagus Nerve Autonomic Disorder

Summary: high velocity low amplitude thrust applied at the vertebral level during spinal manipulation is thought to slide the vertebrae over each other and alter segmental biomechanics.

evidence suggests that spinal hvla techniques may produce acute changes in skin sympathetic nerve activity. there are studies reporting that thoracic hvla manipulation causes a statistically significant increase in cardiac vagal activity in the immediate post-intervention period compared to sham administration.

Eligibility criteria:
inclusion criteria: * people who volunteered to work and signed the consent form * not having any of the application contraindications or exclusion criteria. * being between the ages of 18-45 exclusion criteria: * presence of tumor, infection, trauma, inflammation * neurological problems (acute myelopathy, spinal cord compression, cauda equina syndrome, nerve root compression) * vascular disorders (vertebrobasilar insufficiency or cervical artery abnormalities, aortic aneurysm, angina pectoris, acute abdominal pain with preservation)

Keywords: manipulation
design of a non-invasive multi-modal neonatal monitoring system

Conditions: Neonatal Disorder

Summary: this is a preliminary study whose objectives are to define the clinical use cases and the constraints of the implementation of a multi-sensor image-sound system.

300 000 newborns per year are hospitalized in european neonatal units in the post-natal period. this is a critical period for neurobehavioral development and the establishment of an optimal model of sleep-wake cycle is fundamental for brain development. the objective of the research is to develop new tools for computer-aided clinical and predictive diagnosis and real-time monitoring in neonatology. the development of non-invasive sensors based on video and sound images aims to improve the short- and medium-term prognosis in perinatal patients. to that aim, multi-modal composite indices integrating the image (which is used only to generate a quantification of the movement) and the sound to the bioelectric signals already available (electrocardiogram, oxymetry, temperature) will be developed to provide diagnostic and prognostic information.

Eligibility criteria:
inclusion criteria: * newborns less than 6 weeks old in corrected terms; * newborns in one of the following situations: * persistent discomfort (apneas); * infection or suspicion of infection; * premature with uncomplicated evolution; * premature brain lesion acquired in perinatal; * newborn having been exposed to premature rupture of the membranes. exclusion criteria: * congenital malformation; * metabolic disease.

Keywords: neonates non invasive monitoring
outcome study of complex distal radius fractures

Conditions: Distal Radius Fractures

Summary: the purpose of this study is to collect information about how people do after different treatments of a broken wrist to see if one treatment has better results.

complex distal radius fractures are a common problem treated by orthopaedic surgeons. the purpose of this study is to compare the outcome between complex distal radius fractures treated with open reduction and internal fixation using a volar fixed angled plate versus and external fixator versus drv. the hypothesis is that the volar fixed angled plate will have a superior outcome both radiographically and clinically.

Eligibility criteria:
inclusion criteria: * distal radius fracture exclusion criteria: * none

Keywords: distal radius fractures
"in vivo" comparison in human carotid atherosclerosis: plaque neovascularization

Conditions: Carotid Artery Disease; Plaque Neovascularization

Summary: atherosclerosis may initiate early in life and takes years to progress. this contrasts to the abrupt coronary or cerebrovascular events occurring following the transition from a stable to an unstable atherosclerotic plaque. the causes of this discontinuity of the disease are complex and probably multiple. there is increasing evidence that, besides inflammation, neovascularisation of atherosclerotic plaques and intra-plaque hemorrhages play an important role in plaque instability ending-up frequently in acute thrombotic occlusion or distal embolisation of athero-thrombotic material associated with heart attack or stroke. contrast-enhanced ultrasound, is a bed-side non-invasive technique, which allows to enhance microvascular structures and to visualize the adventitia and intraplaque vascularization. dynamic contrast-enhanced plaque mri (dce-mri) which has also been evaluated for in vivo detection and quantification of plaque neovascularity. together with the presence of a large lipid-rich core, thin fibrous cap, positive remodeling and active inflammatory infiltrate, plaque neovascularisation is considered a valid marker of high-risk (or vulnerable) plaque as demonstrated in histopathological studies using microvessel density. aim of the study is to assess and validate the value of contrast enhanced ultrasound (ceus), a bed-side technique, in detecting plaque neovascularisation and compare it with the quantitative assessment by dce-mri in carotis atherosclerosis. a group of 30 patients with asymptomatic carotid atherosclerosis (\> 50% stenosis on doppler ultrasound) will undergo carotid duplex ultrasounds and ceus. high-resolution plaque mri and dce-mri will be performed in the same patients and will be analyzed by two separate operators blinded to the results of the ceus in order to detect the efficacy of ceus when compared with in vivo dce-mri, as the standard of reference.


Eligibility criteria:
inclusion criteria: * asymptomatic 50-70% carotid artery stenosis on doppler ultrasound * asymptomatic \>70% carotid artery stenosis on doppler ultrasound (no surgical indication) * signed informed consent exclusion criteria: * non atherosclerotic occlusive disease * prior carotid endarterectomy on the site of the index carotid artery * contraindications for mri and ce mri (history of hypersensitivity to gadolinium salt, pacemaker or vascular clip implantation, implantation of any metallic device, severe claustrophobic reactions) * contraindications to ceus (hypersensitivity to sonovue compounds, acute coronary syndromes, acute heart failure, heart failure in nyha class iii or iv, severe arrhythmias, known right-to-left cardiac shunt, severe pulmonary hypertension, uncontrolled arterial hypertension, acute distress respiratory syndrome) * short-term life-threatening pathology (life expectancy \< 6 months) * physically unable to participate in the study * compliance not guaranteed * pregnancy
arousal training for social anxiety disorder

Conditions: Social Anxiety

Summary: the primary objective of the study is to examine the safety, usability and preliminary efficacy of a novel arousal-based biofeedback system in alleviating social anxiety. the investigators hypothesize that after 4 weeks of hour-long interventions, participants will show reductions pre- and post-intervention in their liebowitz social anxiety scale scores.

the investigators plan to conduct a waitlist control trial. intervention consists of a combination of computerized cognitive behavioral therapy and arousal-based virtual reality exposure therapy. during the latter component, the physiological variables of participants, such as pulse rate and eeg, will be continuously monitored and presented as feedback to them. participants will have to deliver speeches to videotaped audiences while striving to regulate their physiological arousal.

Eligibility criteria:
inclusion criteria: * literate in english * computer literate * able to travel independently * agreeable to being video-recorded when going through study protocol * liebowitz social anxiety scale score of 31 or more * public speaking anxiety scale score of 60 or more * alcohol use disorders identification test (audit) of 8 and below exclusion criteria: * has gross visual or hearing impairments * has irregular heart rhythm * on any psychoactive medication * involved in any other long-term research study * current or previous history of neuropsychiatric disorders (other than depression, which will be assessed by bdi-ii) * suicide ideation * concurrent psychotherapy for any disorder * non-responding to a previous psychotherapy

Keywords: virtual reality exposure therapy computerized cognitive behavioral therapy public speaking social phobia biofeedback
biostemi extended survival

Conditions: Coronary Artery Disease; Acute Coronary Syndrome

Summary: the objective of the biostemi es study is to assess the long-term clinical outcomes with the orsiro ultrathin-strut biodegradable polymer sirolimus-eluting stent compared to the xience thin-strut durable polymer everolimus-eluting stent up to 5 years of follow-up among patients with stemi undergoing primary pci, enrolled in the biostemi trial.

the objective of the biostemi es study is to assess the long-term clinical outcomes with the orsiro ultrathin-strut biodegradable polymer sirolimus-eluting stent compared to the xience thin-strut durable polymer everolimus-eluting stent up to 5 years of follow-up among patients with stemi undergoing primary pci, enrolled in the biostemi trial. * in the biostemi randomized controlled clinical trial, the orsiro ultrathin-strut bio degradable polymer sirolimus-eluting stent was found superior to the best-in-class xience thin-strut durable polymer everolimus-eluting stent with respect to target lesion failure at one-year follow-up among patients with stemi undergoing primary pci (iglesias jf, et al., lancet 2019). the difference was driven by a lower risk of clinically indicated target lesion revascularization with the orsiro ultrathin-strut biodegradable polymer sirolimus-eluting stent compared to the xience thin-strut durable polymer everolimus-eluting stent. * importantly, the difference between orsiro stent and xience stent accrues over time between one and two years of follow-up. * as per study protocol, the planned follow-up of patients included in the biostemi randomized controlled trial was 2 years. * the long-term clinical benefits the orsiro ultrathin-strut biodegradable polymer sirolimus-eluting stent over the xience thin-strut durable polymer everolimus-eluting stent beyond the polymer degradation period remain uncertain.

Eligibility criteria:
inclusion criteria: * subjects that were enrolled in the biostemi trial (basec: 2016-00555), * subject willing and able to provide oral informed consent. exclusion criteria: * no specific exclusion criteria.

Keywords: st-segment elevation myocardial infarction long-term outcomes primary pci
rosuvastatin and ischemia reperfusion

Conditions: Ischemia

Summary: statins, including rosuvastatin, are drugs that lower plasma cholesterol and prevent atherosclerotic disease. recent preclinical evidence suggests that statins also increase tissue tolerance to ischemia-reperfusion injury. this is a randomized, double blind, parallel designed study comparing the effect of 1 week treatment with rosuvastatin (20 mg, once a day) with placebo on forearm ischemia-reperfusion injury in healthy male volunteers. forearm ischemia-reperfusion injury is quantified with tc-99m-annexin a5 scintigraphy of the hands after a standardized ischemic exercise test. for this purpose, tc-99m-rh-annexin a5 (400 mbq; \< 5 msv) is injected intravenously upon reperfusion, followed by scintigraphy of both hands with a gamma camera at 1 and 4 hours after injection. annexin a5 targeting is calculated as the percentage difference in activity (counts/pixel) between the thenar muscles of both hands.


Eligibility criteria:
inclusion criteria: * healthy volunteers (18-50 years of age) exclusion criteria: * hypercholesterolemia * hypertension

Keywords: ischemia-reperfusion annexin a5
assessment of remote approaches for identification of autonomic dysfunction among survivors of leukemia and lymphoma

Conditions: Childhood Cancer

Summary: this study seeks to determine if diagnosing cardiac autonomic dysfunction (ad) can be done remotely with the same accuracy as in-person testing. if so, the identification of ad could happen sooner, facilitating remote studies of the condition and potentially reducing the risk of illness. childhood cancer survivors, particularly survivors of acute lymphoblastic leukemia (all) and hodgkins's lymphoma (hl), appear to be at increased risk for ad. primary objectives: * to determine the sensitivity and specificity of heart rate variability (hrv), measured remotely with biosensor technology (actigraph leap), compared to in-person assessment using the ewing battery as the reference standard to identify cardiac autonomic dysfunction (ad) among survivors of leukemia and lymphoma. * to determine the sensitivity and specificity of the composite autonomic symptom scale 31 (compass31) compared to the ewing battery to identify ad among leukemia and lymphoma survivors.

each participant will complete an in-person standardized clinical assessment for ad, called the ewing battery. during the participants' human performance lab during their sjlife functional exam. it is estimated it will take 60-90-minutes to complete the ewing battery. the tests include monitoring heart rate variations during deep breathing and lying down to standing, as well as monitoring blood pressure variations when standing and maintaining hand grip. participants will be asked to not consume aspirin, ibuprofen or acetaminophen 24-hours before the assessment. additionally, participants will be asked to avoid alcohol or caffeine within 6-hours, and smoking 3-hours, before testing. after the in-person assessment, each participant will be given a wrist biosensor to remotely monitor heart rate variability for 7 days after they return home. participants will also complete an ad symptom questionnaire, compass31. the ad symptom questionnaire will be completed either before or after the in-person assessment. this questionnaire will take about 20-30 minutes to complete.

Eligibility criteria:
inclusion criteria: * participants enrolled in st. jude lifetime cohort (sjlife) \>18 years of age. * primary diagnosis of acute lymphoblastic leukemia (all), hodgkin's lymphoma (hl), or non-hodgkin's lymphoma (non-hl). * not currently taking beta-blocker medication. exclusion criteria: * individuals who cannot speak, read, and/or understand english. * individuals who are unable to follow directions/instructions in order to complete the ewing battery. * individuals with acute heart failure (new or worsening signs and symptoms of heart failure, including a combination of the following: dyspnea, orthopnea, lower limb swelling, elevated jugular venous pressure, and pulmonary congestion). * women who are currently pregnant.

Keywords: survivor acute lymphoblastic leukemia hodgkins's lymphoma autonomic
laparoscopic treatment of common bile duct stones : what are the limits and when should we call the endoscopist ?

Conditions: Laparoscopic; Common Bile Duct Stone With Chronic Cholecystitis

Summary: the aim of this study was to identify some risk factors of failure of surgical management of common bile duct stones, in our center between 2007 and 2019.

lithiasis disease represents a real public health problem. indeed, 10% of the general population is asymptomatic carrier of gallbladder stones and among them, 35% will present a symptomatic form which will cause the indication of cholecystectomy. as a result, around 120,000 cholecystectomies are performed per year in france, and around 750,000 in the united states for this indication. cholecystectomy is therefore the most widely performed procedure in the world. however, in 3 to 20% of cases, common bile duct stones will be associated and to be treated. different strategies are proposed: a treatment called "all surgical" or an endoscopic treatment (usually a sphincterotomy) before, after or during a cholecystectomy. the investigators defined two groups of patients: one group with success of fully laparoscopic surgical treatment (cholecystectomy and laparoscopic exploration of the common bile duct at the same time), and one group treated by laparoscopic cholecystectomy and management of the common bile duct stone(s) by an ercp performed intra, per ou postoperatively. the primary outcome was the failure of surgical management, defined as the requirement of ercp for extraction of common bile duct stones, which permit us to identify risk factors of failure in the fullfil surgical treatment process. the secondary outcome was to study the morbimortality in each group, and length of stay.

Eligibility criteria:
inclusion criteria: * more than 18 years old * between 2007 and 2019 * montpellier university hospital * laparoscopic cholecystectomy for symptomatic cholelithiasis associated to common bile duct stones * common bile duct stones highlighted on preoperative imaging or intraoperative cholangiography * common bile duct stones treated during the same hospital stay surgically or endocopically exclusion criteria: * laparotomy * previous ercp * less than 18 years old * lost to follow up * lack of data \> 10% * other surgical procedure associated at the same time * previous cholecystectomy * caroli's disease * severe cholangitis or acute pancreatitis * pigmentary or hydatic lithiasis * laparoscopic cholecystectomy for other indication than symptomatic cholelithiasis

Keywords: common bile duct stones laparoscopic common bile duct exploration (lcbde) ercp morbimortality
ephedrine versus phenylephrine for spinal block - related hypotension in cesarean delivery

Conditions: Spinal Anesthesia; Cesarean Delivery; Neonatal Acidosis

Summary: the study is designed to compare two strategies used in the management of hypotension caused by spinal anesthesia for cesarean section: intravenous phenylephrine given as prophylactic infusion and interventional boluses of intravenous ephedrine. phenylephrine is currently recommended for battling spinal anesthesia - related sympathectomy, due to some scientific data on possible negative effects of ephedrine on fetal wellbeing. therefore this study will retrospectively compare both clinical and laboratory data of the newborns delivered by cesarean section where either large dose of ephedrine or continuous infusion of phenylephrine was used for management of hypotension

single - shot spinal block is a gold standard of anesthesia for cesarean delivery. it has been proven to decrease maternal morbidity and improve neonatal outcomes. despite being most frequently used type of anesthesia in obstetrics, spinal block - related complications remain frequent in term parturients, of which hypotension is of utmost importance. two widely accepted medications used in its prevention and treatment are phenylephrine and ephedrine, of which continuous, preventive phenylephrine infusion is considered superior in terms of neonatal safety. although there is some scientific evidence towards ephedrine having negative effect on neonatal acid - base status, it is still the most popular vasoconstrictor used for management of perioperative hypotension in poland. it is an indirect adrenergic agonist, acting through release of noradrenaline from peripheral nerve endings. beta - receptors mediated adrenergic stimulation of neonatal tissues is thought to be responsible for endocrine abnormalities, acid - base disturbances and possibly worse apgar scores. phenylephrine on the other hand is a direct and selective alpha-1 agonist and is regarded to exert very little or even no neonatal effects. maternal complications related to phenylephrine infusion is hypertension and reflex bradycardia. as convincing evidence is still lacking, this study is designed to retrospectively compare neonatal outcomes and perioperative hemodynamic data of mothers where either infusion of phenylephrine or boluses of ephedrine were used to control spinal -related hypotension during cesarean section.

Eligibility criteria:
inclusion criteria: * cesarean delivery at term under spinal anesthesia * american society of anesthesiologists (asa) physical status \<3 * bmi \<40 * preemptive phenylephrine infusion or ephedrine boluses used during surgical procedure exclusion criteria: * no vasoconstrictor (phenylephrine nor ephedrine) used throughout the procedure * total dose of ephedrine less than 15mg * poor quality of anesthetic record - data required for analysis not available

Keywords: cesarean delivery spinal anesthesia phenylephrine ephedrine hypotension