Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of aspirin in patients with chronic coronary syndromes without revascularization

Conditions: Stable Angina Pectoris; Coronary Artery Disease; Ischemic Heart Disease

Summary: the purpose of this study is to evaluate the efficacy and safety aspirin in patients with chronic coronary syndromes without revascularization.

aspirin for secondary prevention in the acute phase of acute coronary syndromes has been established. although it is still disputable about the duration, there is also a consensus for antiplatelet therapy in patients after percutaneous coronary revascularization. on the other hand, several large randomized clinical trials (rcts) have shown that aspirin treatment for primary prevention of cardiovascular events increases bleeding events and does not provide net clinical benefit.patient with chronic coronary syndromes (ccs) but not eligible for revascularization do not belong to any of these categories and there is no evidence on the efficacy of aspirin in this population. therefore, we designed a multicenter, randomized, open-label study to evaluate the efficacy and safety of aspirin in patients with ccs who are not eligible for revascularization.

Eligibility criteria:
inclusion criteria: * patients with chronic coronary syndromes with ≧50% diameter stenosis in one or more major coronary vessels/major branches on coronary ct or coronary angiography but not eligible for coronary revascularization * patients for whom consent can be obtained exclusion criteria: * patients with history of acute coronary syndromes (acs) * patients with history of percutaneous coronary intervention (pci) or coronary artery bypass graft (cabg) * patients with left main trunk stenosis (≥50%) * patients for whom aspirin administration is mandatory * patients undergoing antithrombotic therapy other than aspirin * patients with atrial fibrillation * patients with history of stroke within six months * patients scheduled for major surgical procedures that will require aspirin discontinuation * patients with contraindication of aspirin * patients expected to have a prognosis of 1 year or less due to comorbidities * women of child-bearing potential or women who have a positive pregnancy test at enrolment or randomization * patients who are judged by attending physicians to be inappropriate to participate in this study

Keywords: chronic coronary syndrome aspirin
the effects of aerobic exercise in patients with ankylosing spondylitis

Conditions: Ankylosing Spondylitis; Aerobic Exercise; Disease Activity

Summary: the aim of our study is to investigate the effects of aerobic exercise and stretching exercises applied in high-intensity interval training protocol on disease activity, quality of life, spinal mobility and calprotectin, visfatin, leptin, il-33 serum levels in patients with ankylosing spondylitis.

ankylosing spondylitis (as) is a painful and progressive chronic inflammation of the axial skeleton, mainly affecting the vertebral and sacroiliac joints. the management of as aims to improve and maintain spinal mobility and normal posture, alleviate symptoms, reduce functional limitations and minimise complications. due to the characteristic features of the disease, recommended spinal mobility exercises and aerobic exercises focus on reducing symptoms, improving functional capacity and quality of life, and improving and maintaining spinal mobility. calprotectin, visfatin, leptin can be evaluated as biomarkers in inflammatory rheumatic diseases as an alternative to acute phase proteins and may reflect disease activity. this study was designed as a prospective randomised controlled trial. participants will be randomized into 2 groups and the intervention group will be given aerobic exercise and stretching exercise, and the other group only stretching exercise. basdai, basmi, basfi, asqol, asdas-crp, chest expansion, 6 minute walk test and borg scale will be used as assessment parameters. calprotectin, visfatin, leptin, il-33 serum levels will be analysed by elisa kit with blood samples taken in the early morning at the beginning of treatment, at the end of treatment (4th week) and at the 12th week after the beginning of treatment.

Eligibility criteria:
inclusion criteria: * diagnosed with ankylosing spondylitis according to 2009 asas diagnostic criteria, * 20-60 years old, male and female gender, * no change in anti-rheumatic drugs and dosage in the last 3 months * those who have not done regular physical activity in the last 3 months, * patients who do not have any orthopedic, neurological or mental illness that may affect exercise will be included in the study. exclusion criteria: * active malignancy and/or history of malignancy in the last 5 years, * uncontrolled cardiopulmonary disease, * unstable angina pectoris, cardiac arrhythmias and myocardial infarction within the last 3 months * presence of pregnancy or those planning a pregnancy in the near future, * history of major surgery (including joint surgery) within the last six months * use of assistive devices for ambulation or orthopaedic joint prosthesis * patients with total spinal ankyloses * patients with a history of syncope, exercise-induced arrhythmia * regular exercise in the last 3 months * patients with contracture of the knee joint that prevents cycling exercise

Keywords: ankylosing spondylitis spinal mobility aerobic exercise
the effect of home midwifery care given to pregnant women diagnosed with gestational diabetes on attitudes and self-care

Conditions: Gestational Diabetes; Pregnancy, High Risk

Summary: since gestational diabetes carries the risk of serious complications for the mother and fetus, it is very important to follow up the pregnancy carefully and consciously. home follow-up and prenatal care of these pregnant women, whose outpatient follow-up is continued without hospitalization, gains great importance. this study was planned as a randomized controlled experimental study to determine the effects of home midwifery care based on the continuous midwifery care model for pregnant women diagnosed with gestational diabetes, on the attitudes and self-care of pregnant women. the universe of this research, which will be carried out in a randomized controlled experimental type, will consist of pregnant women who applied to çukurova university balcalı hospital health application and research center gynecology and obstetrics department pregnancy polyclinic. the sample number was calculated by the sample size calculator analysis and it was planned to include 24 participants in the experimental group and 24 participants in the control group. single-blind randomized assignment and block randomization will be performed to avoid selection bias. the research will be conducted in the form of pre-test and post-test. the pre-test will be applied at the first encounter before the midwifery training, and the post-test will be applied after the 6th training. data; it will be collected with the pregnant introductory form, intention, attitude and behavior scale in gestational diabetes and diabetes self-care activities questionnaire. statistical program for social science 22 will be used in data analysis. the data will be analyzed with appropriate analysis methods after testing for normality. the main subject of this research is to improve maternal and fetal health by providing continuous midwifery care at home for pregnant women who are diagnosed with gestational diabetes and are in the risky pregnancies group. with individual and continuous midwifery care provided at home, the self-care of women is strengthened and the intention, behavior and attitude towards both pregnancy and the health problem she has experienced are positively affected, contributing to the reduction of possible complications and providing a cost-effective service reveals the importance and necessity of the research.

this study was planned as a randomized controlled study to determine the effect of home midwifery care given to pregnant women diagnosed with gestational diabetes on the attitudes and self-care of pregnant women.

Eligibility criteria:
inclusion criteria: * knowing turkish and being literate * absence of fetal anomaly * having been diagnosed with gestational diabetes * 24-28 and above gestational weeks exclusion criteria: * communication difficulties

Keywords: midwifery home care gestational diabetes attitude, self care
effect of teas combined with oxycodone on postoperative visceral pain in gynecologic laparoscopic patients

Conditions: Visceral Pain

Summary: to investigate the effect and feasibility of percutaneous acupoint stimulation combined with oxycodone on postoperative visceral pain in laparoscopic patients, and provided a clinical basis for optimizing perioperative pain management in laparoscopic patients.

patients aged 18-65 years old, bmi 18-30kg/m2, asa grade i or ii were selected for gynecologic laparoscopic surgery (laparoscopic ovarian tumor stripping, laparoscopic uterine fibroid stripping, laparoscopic total hysterectomy) under general anesthesia from may 2024 to july 2024. exclusion criteria: patients who were allergic to the drugs used in the study, had confusion or cognitive impairment, contraindicated percutaneous acupoint electrical stimulation, abnormal cardiopulmonary and liver and kidney function, history of analgesic drug use within one week, history of diabetes, myocardial infarction, or cerebrovascular accident. exclusion criteria: patients dropped out of the experiment midway or the data was not completely collected, the surgical method changed midway, the operation duration was less than 30 minutes or more than 2 hours, and patients with opioid and addictive drug dependence

Eligibility criteria:
inclusion criteria: * age 18-65 years * american society of anesthesiologists grade i-ii * body mass index (bmi) 18.5-30 kg/m2; * no ulceration or infection at the acupuncture stimulation site. exclusion criteria: * allergic to the drugs used in the study; * people with unclear consciousness or cognitive dysfunction; * there are contraindications of percutaneous acupoint electrical stimulation; * abnormal cardiopulmonary and liver and kidney function; * history of analgesic drug use within one week; * history of diabetes, myocardial infarction or cerebrovascular accident.
expression of fas protein in skin biopsies of participants with scarring alopecia

Conditions: Central Centrifugal Scarring Alopecia; Lichen Planopilaris; Discoid Lupus Erythematosus

Summary: the purpose of this research study is to see if a specific protein that we are interested in is involved in scarring hair loss. if these proteins are involved, further genetic work may also better define the disease as well as future treatment options.

this is a single-center study, designed to evaluate the expression of fas protein in skin biopsies of patients with scarring alopecia including fourteen patients with central centrifugal scarring alopecia (ccsa), three patients with lichen planopilaris (lp) and three patients with discoid lupus erythematosus (dle). skin biopsies of five healthy participants will be used as controls.

Eligibility criteria:
inclusion criteria: * participants ages 30 years or older with a biopsy- proven diagnosis of ccsa. * undergone standard of care treatment for ccsa by a wfusm dermatologist * women of child bearing age will be required to have a negative pregnancy test in order to participate in the study * participants ages 30 years or older with a biopsy- proven diagnosis of lp. * participants ages 30 years or older with a biopsy- proven diagnosis of dle. * healthy participants must be ages 30 years or older. exclusion criteria: * age less than 30 years of age. * clinically evident bacterial or viral infection of the scalp. * pregnant or nursing woman of child-bearing potential. * participation in any other investigative research study involving study medication. * inability to return for the biopsy visit.

Keywords: alopecia lupus
prospective observational study of intralesional treatment with pentostam in cutaneous leishmaniasis israeli patients

Conditions: Cutaneous Leishmaniasis

Summary: cutaneous leishmaniasis (cl) is endemic in israel and is caused by leishmania major or leishmania tropica. cl is usually a benign disease and limited to the skin. one of the local treatment available is intralesional (il) pentostam injection. during the current study the investigators will monitor the adverse effects of this treatment and will follow up the recovery of the lesions after pentostam injections.

cutaneous leishmaniasis is usually treated by topical intervention. in more severe cases intralesional pentostam injection may be applied. this treatment is extremely efficient but painful, however without the known adverse effects of iv pentostam treatment. in this study the investigators will follow systematically all leishmania patients who are receiving the intralesional treatment. a structured questionnaire will be filled up in each doctor visit. the current study goal is to examine the adverse effects and the patient reaction to this treatment, and to follow the recovery of lesion(s) after this treatment including the number of il injections which was needed.

Eligibility criteria:
inclusion criteria: * cutaneous leishmaniasis patients * treatment by il pentostam * age above 18 years exclusion criteria: * children and pregnant women will not participate in the study
combination chemotherapy and radiation therapy followed by surgery in treating patients with stage iib or stage iiia non-small cell lung cancer

Conditions: Lung Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. radiation therapy uses high-energy x-rays to damage tumor cells. combining these treatments before surgery may kill more tumor cells in patients with non-small cell lung cancer. purpose: phase ii trial to study the effectiveness of combining chemotherapy with radiation therapy before surgery in treating patients who have stage iib non-small cell lung cancer or stage iiia non-small cell lung cancer.

objectives: * determine the response rate, duration of response, and survival in patients with bulky stage iib or stage iiia non-small cell lung cancer treated with paclitaxel, carboplatin, and radiotherapy followed by surgical resection. * assess the toxicity of this regimen in this patient population. outline: this is a multicenter study. patients receive paclitaxel iv over 1 hour and carboplatin iv over 30 minutes weekly for 5 weeks. patients also undergo concurrent radiotherapy daily 5 days a week for 5 weeks in the absence of unacceptable toxicity. at approximately 4 weeks after completion of chemoradiotherapy, patients with stable or regressive disease undergo surgical resection. if disease is unresectable, patients receive an additional 2 weeks of radiotherapy. patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter. projected accrual: a total of 29-30 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed bulky stage iib or stage iiia non-small cell lung cancer * ipsilateral mediastinal node involvement by mediastinoscopy * no contralateral lymph node involvement * no malignant pleural effusion * no distant metastases patient characteristics: age: * 18 and over performance status: * ecog 0-1 life expectancy: * not specified hematopoietic: * granulocyte count at least 1,500/mm\^3 * platelet count at least 100,000/mm\^3 * hemoglobin at least 10 g/dl hepatic: * alt/ast less than 2 times upper limit of normal * bilirubin no greater than 1.5 mg/dl renal: * creatinine no greater than 2.0 mg/dl other: * not pregnant or nursing * negative pregnancy test * fertile patients must use effective contraception * no other prior malignancy within the past 5 years except adequately treated carcinoma in situ of the cervix or nonmelanoma skin cancer prior concurrent therapy: biologic therapy: * not specified chemotherapy: * no prior chemotherapy endocrine therapy: * not specified radiotherapy: * no prior radiotherapy surgery: * see disease characteristics

Keywords: stage ii non-small cell lung cancer stage iiia non-small cell lung cancer
deep vein thrombosis prophylaxis adherence: enoxaparin vs rivaroxaban

Conditions: Deep Vein Thrombosis; Venous Thromboembolism

Summary: the objective of this study is to compare oral rivaroxaban with injectable enoxaparin in orthopaedic trauma patients to determine if orally administered rivaroxaban once daily carries greater compliance and overall satisfaction than enoxaparin self-administered by subcutaneous injection once daily.

this study is a randomized, controlled trial of orthopaedic trauma patients presenting to a single academic level one trauma center that require an extended course of venous thromboembolism event chemoprophylaxis. the goal is to compare oral rivaroxaban with our standard-of-care, injectable enoxaparin in orthopaedic trauma patients to determine if orally administered rivaroxaban once daily carries greater compliance and overall satisfaction than enoxaparin self-administered by subcutaneous injection once daily. all patients included in the study would be treated with the standard enoxaparin 40 milligram injection while an inpatient. upon hospital discharge, those requiring extended venous thromboembolism event chemoprophylaxis will be randomized to receive 20 days of either self-injected enoxaparin 40 milligrams or oral rivaroxaban,10 milligrams, a non-vitamin k oral anticoagulant. both groups will then receive our current standard of care, aspirin 81 milligrams once daily for the remaining 3 weeks, for a total of 6 weeks of venous thromboembolism event chemoprophylaxis. routine postoperative care will be provided by the treating surgeon.

Eligibility criteria:
inclusion criteria: * • orthopaedic trauma patients deemed by the attending, treating surgeon to require an extended duration of venous thromboembolism chemoprophylaxis beyond that provided as an inpatient. * patients being discharged directly to home. exclusion criteria: * • patients being discharged to a rehabilitation center or a skilled nursing facility. * a contraindication to anticoagulation such as traumatic or other hemorrhage, as determined by the treating surgeon and/or consulting services. * ongoing venous thromboembolism treatment or extended prophylaxis (i.e. past history of multiple deep vein thrombosis/pulmonary embolism) for current or recent deep vein thrombosis, pulmonary embolism or other coagulopathic disorder * chronic anticoagulation for atrial fibrillation or other medical disorder requiring chronic anticoagulation therapy. * perceived low-risk patients requiring only aspirin or no pharmacological venous thromboembolism prophylaxis. * pregnant, prisoner, under 18 years old, or do not speak english
long term memory preoperative preparation reduce post operative behavioral change

Conditions: Behavior; Agitation

Summary: the study is designed to test the hypothesis that long term memory created by preoperative video information can reduce the incidence of post operative behavioral changes.

emergence agitation (ea) and post operative behavioral change (phc) are unpleasant experiences occurred in children after general anesthesia (ga). previous study reported that the patient who had marked ea tended to have new-onset of postoperative maladaptive behavioral changes.both pharmacologic and non pharmacologic interventions such as preoperative video information, hand held video games were used to reduce preoperative anxiety, ea and post operative behavioral changes. in term of memory creation, short term memory (stm) was created. later that the formation of memory trace requires time, and that this trace remains fragile until the long term memory formation process has been completed. in this study, the investigators hypothetize that long term memory created by preoperative video information can reduce the incidence of post operative behavioral changes.

Eligibility criteria:
inclusion criteria: * outpatient elective surgery * aged between 3-14 years * asa physical status i-ii exclusion criteria: * mental retardation * patient's telephone contact not available * emergency case * having icu admission plan postoperative

Keywords: post operative behavioral changes pediatric long term memory video
impact of mindfulness intervention on quality of life in patients with drug-resistant epilepsy.

Conditions: Drug Resistant Epilepsy

Summary: this study evaluates a mindfulness intervention in patients with drug resistant epilepsy. half of participants will follow a mindfulness programme, while the other half will follow a self management programme.

drug-resistant epilepsy is associated with an alteration of the quality of life mainly related to psychiatric comorbidities (anxiety and depression). the management of these comorbidities is therefore essential in patients with drug resistant epilepsy, ideally through non-drug management to minimize the side effects of molecules. the goal of mindfulness interventions in pathology is to learn to better live with a chronic disease by reducing the stress resulting from the disease, by increasing benevolence towards oneself, the acceptance of the disease and reducing the ruminations linked with the pathology. mindfulness therefore seems to be a good way for these patients to improve the management of their emotions and thus improve their quality of life what the investigators propose to evaluate in this study. the study consists of two phases 1. first phase: comparative randomized study (primary endpoint): 1. after inclusion, a 2 months baseline follow-up is carry to collect the judgement criteria without intervention. 2. at the end of this period, patients will be randomly assigned to the mindfulness intervention group or the control group with the psycho educative programme. both programmes will takes 3 months. 3. then a 6-months post-intervention follow-up period for both groups patients will have assessment visits every 3 months. they will also complete a daily notebook including the number of seizures they have done and a scale of their "interior weather". 2. second phase (optional): at the end of the first phase, patients in the control group will be able to benefit from the mindfulness programme and will be followed at the end of the programme for 6 months.

Eligibility criteria:
inclusion criteria: * drug resistant epilepsy according to the criteria of the international league against epilepsy (ilae) * stable therapy for at least 3 months * no planned surgery * patient affiliated to social security insurance or beneficiary of social security insurance. * signed consent exclusion criteria: * patient who has previously had or regularly practicing mindfulness * patient with psychogenic non-epileptic seizures * pregnant woman, breastfeeding mother, person deprived of liberty by judicial or administrative decision, person subject to legal protection * patient with relationship disorders related to psychosis * patients who are unable or unwilling to work as a group or person unable to understand the topics discussed during session.

Keywords: drug resistant epilepsy mindfulness self management
auto-evaluation of dyspnea

Conditions: Lung Diseases

Summary: the primary aim of this study was to compare patients-rated evaluation and caregiver's assessment of dyspnea with the standard tools in pulmonology unit (borg scale and visual analog scale) and the secondary aim was to performed an analysis depending on the diseases (lung cancer vs. other lung diseases) and to verify the agreement between the evaluation between both visual analog scale and modified borg scale.


Eligibility criteria:
inclusion criteria: * age ≥18 and * to have a diagnosis of acute or chronic respiratory disease exclusion criteria: * mental or cognitive disorders * inability to understand the local language