biomarkers in patients with head and neck cancer and in healthy volunteers

Conditions: Head and Neck Cancer

Summary: rationale: studying samples of blood, tissue, and saliva in the laboratory from patients with cancer and from healthy volunteers may help doctors identify and learn more about biomarkers related to cancer. purpose: this laboratory study is looking at biomarkers in patients with head and neck cancer and in healthy volunteers.

objectives: * correlate the differences in serum protein profiles with the differences in the number of peptide matches in patients with squamous cell carcinoma of the head and neck and in healthy volunteers. * correlate protein levels with the largest difference in peptide matches in sera in these participants. outline: this is a prospective study. participants undergo blood, tissue, and saliva collection for biological studies. samples are analyzed for albumin-bound and non-albumin-bound proteins or igg via liquid chromatography and tandem mass spectrometry (lc-ms-ms), elisa, proteomic profiling, and protein expression. projected accrual: a total of 50 patients and 50 healthy volunteers will be accrued for this study.

Eligibility criteria:
disease characteristics: * meets one of the following criteria: * diagnosis of squamous cell carcinoma of the head and neck * healthy volunteer matched by sex, race, birth decade, or smoking status (e.g., current smoker, former smoker, or nonsmoker) patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: metastatic squamous neck cancer with occult primary squamous cell carcinoma recurrent squamous cell carcinoma of the hypopharynx recurrent squamous cell carcinoma of the larynx recurrent squamous cell carcinoma of the lip and oral cavity recurrent squamous cell carcinoma of the nasopharynx recurrent squamous cell carcinoma of the oropharynx recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity stage i squamous cell carcinoma of the hypopharynx stage i squamous cell carcinoma of the larynx stage i squamous cell carcinoma of the lip and oral cavity stage i squamous cell carcinoma of the nasopharynx stage i squamous cell carcinoma of the oropharynx stage i squamous cell carcinoma of the paranasal sinus and nasal cavity stage ii squamous cell carcinoma of the hypopharynx stage ii squamous cell carcinoma of the larynx stage ii squamous cell carcinoma of the lip and oral cavity stage ii squamous cell carcinoma of the nasopharynx stage ii squamous cell carcinoma of the oropharynx stage ii squamous cell carcinoma of the paranasal sinus and nasal cavity stage iii squamous cell carcinoma of the hypopharynx stage iii squamous cell carcinoma of the larynx stage iii squamous cell carcinoma of the lip and oral cavity stage iii squamous cell carcinoma of the nasopharynx stage iii squamous cell carcinoma of the oropharynx stage iii squamous cell carcinoma of the paranasal sinus and nasal cavity stage iv squamous cell carcinoma of the hypopharynx stage iv squamous cell carcinoma of the larynx stage iv squamous cell carcinoma of the lip and oral cavity stage iv squamous cell carcinoma of the nasopharynx stage iv squamous cell carcinoma of the oropharynx stage iv squamous cell carcinoma of the paranasal sinus and nasal cavity untreated metastatic squamous neck cancer with occult primary recurrent metastatic squamous neck cancer with occult primary recurrent salivary gland cancer salivary gland squamous cell carcinoma stage i salivary gland cancer stage ii salivary gland cancer stage iii salivary gland cancer stage iv salivary gland cancer