Kornimate/medical-research-clean huggingface dataset:
the american society of hematology (ash) research registry: a multicenter research registry of patients with hematologic disease

Conditions: Benign and Malignant Hematologic Diseases

Summary: this is a multicenter, retrospective and prospective, long-term registry of patients with benign or malignant hematologic diseases, whether or not these patients were or were not treated with disease-specific treatments. information will be collected on patient demographics, disease characteristics, genomic and molecular data, laboratory data, pathology, radiographic reports, clinical status, quality of life, medications, and dosing information. where appropriate, these data structures may be based on a combination of fast healthcare interoperability resources (fhir) , consolidated-clinical data architecture (c-cda) and/or client-speciﬁc structure deﬁnitions.

the primary goal of the ash registry is to further the scientific knowledge base for the diagnosis, understanding, and management of benign and malignant hematologic conditions by assembling data collected in usual care and clinical trials. secondary goals are to characterize and study practice patterns for benign and malignant hematologic conditions in usual clinical practice, and to aggregate patient-reported data to further understand and improve the patient experiences of those affected by these conditions. these objectives will be fulfilled by amassing previously collected data within institutions and networks, and by building consortia of institutions and networks to support prospective data collection efforts. as a research-focused effort, another objective of the ash registry is to create a learning community of hematologic researchers and clinicians by inviting collaborative analyses and publications of the data that are collected within it. these analyses may be valuable to basic and translational researchers developing new lines of scientific inquiry; clinical researchers studying the safety and efficacy of hematologic therapies in current practice; industry participants developing new therapies or new indications for previously developed treatments; regulators who are interested in new endpoints and other insights to facilitate the evaluation of novel approaches; and patients who are looking to understand how hematologic diseases and treatments for these diseases will affect their lives. as these different stakeholder groups come together to develop and disseminate these analyses, the ash registry will further expand to accommodate additional data collection to address yet unanswered questions that follow.

Eligibility criteria:
inclusion criteria: * patients (\>18 years of age) must have diagnostically- or investigator-confirmed benign or malignant hematologic disease. * for prospective data collection efforts within the ash registry that require informed consent, children (\<18 years of age) with hematologic disease whose parent/legal guardian consents on their behalf may be included. exclusion criteria: * adults that are unable to consent. * prisoners

Keywords: multiple myeloma sickle cell disease
study of attention and memory treatments for cancer survivors

Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this clinical trial investigates if certain electronic games may be effective in improving attention and memory function in cancer survivors. cancer related cognitive impairment (crci) is an issue experienced by many cancer patients/survivors. crci includes perceived or objective problems with memory, executive function, and attention/concentration. crci has a negative impact on survivors' ability to work, carry out routine activities, and engage in social and family relationships. crci may result in significant distress and reduced quality of life. certain electronic games may help improve attention and memory function in cancer survivors and reduce symptoms of crci.

primary objectives: i. determine the recruitment and retention rates for both arms of this study. ii. determine the effect size for changes in cognitive function (i.e., test of variables of attention (tova) \[i.e. attention\], adaptive cognitive evaluation (ace) \[i.e. working memory\]) in the intervention group compared to the control group following the 4-week study. iii. evaluate adherence rates for and satisfaction with the interventions. iv. evaluate for treatment-related adverse events (e.g., nausea, motion sickness). secondary objective: i. to determine effect sizes for depression, fatigue, and sleep disturbance, by comparing changes in the intervention group to changes in the control group, following the 4-week study. outline: patients are randomized to 1 of 2 arms. arm i: patients play endeavor over 25 minutes daily 5 days a week for 4 weeks. arm ii: patients play words! over 25 minutes daily 5 days a week for 4 weeks.

Eligibility criteria:
inclusion criteria: * attention function index (afi) score of \< 7.5 * are able to read, write, and understand english * ability to understand an electronic informed consent document, and the willingness to sign it * have a karnofsky performance status (kps) score of \>= 50 * have access to wifi connection exclusion criteria: * receiving active treatment for cancer recurrence * have significant cognitive impairment * have sensory or motor deficits that prevent them from doing the assessment and using the application
does bladder training improve the efficacy of nerve stimulation in women with refractory overactive bladders

Conditions: Overactive Bladder

Summary: overactive bladder (oab) is a chronic condition defined as urgency with or without incontinence usually associated with frequency and nocturia. it is a common condition affecting 15-45% of adults and constitutes a significant proportion of patients attending urogynaecology clinics. oab is known to have a significant impact on the physical, social and emotional quality of life and sexual function in women. the treatment of oab is initially conservative with bladder training followed by pharmacotherapy. evidence from a recent cochrane review on treatment of oab suggests that the efficacy of anticholinergics in treatment of oab is enhanced when combined with bt. women who fail to improve with these initial measures are offered intravesical botox or neuromodulation in the form of percutaneous tibial nerve stimulation (ptns) or sacral nerve stimulation (sns). ptns has also been shown to more effective than pharmacotherapy with anticholinergics. in 2010 national institute of clinical excellences (nice) issued guidance stating '"ptns for oab demonstrates effectiveness without major safety concerns" we hypothesise that the outcome of ptns will improve if the ptns sessions are combined with bladder training (bt).


Eligibility criteria:
inclusion criteria: * all women with refractory oab who are offered ptns as a treatment option exclusion criteria: * who cannot give informed consent. * women in whom ptns is contraindicated. this includes women who have: gross leg oedema a pacemaker

Keywords: bladder training percutaneous tibial nerve stimulation overactive bladder randomised controlled study
efficacy, safety, and tolerability study of oral ubrogepant in the acute treatment of migraine

Conditions: Migraine, With or Without Aura

Summary: this study will evaluate the efficacy, safety, and tolerability of 2 doses of ubrogepant (50 and 100 mg) compared to placebo for the acute treatment of a single migraine attack.


Eligibility criteria:
inclusion criteria: * at least a 1-year history of migraine with or without aura consistent with a diagnosis according to the international classification of headache disorders, 3rd edition, beta version * migraine onset before age 50 * history of migraines typically lasting between 4 and 72 hours if untreated or treated unsuccessfully and migraine episodes are separated by at least 48 hours of headache pain freedom * history of 2 to 8 migraine attacks per month with moderate to severe headache pain in each of the previous 3 months. exclusion criteria: * difficulty distinguishing migraine headache from other headaches * has taken medication for acute treatment of headache (including acetaminophen, nonsteroidal anti-inflammatory drugs \[nsaids\], triptans, ergotamine, opioids, or combination analgesics) on 10 or more days per month in the previous 3 months * has a history of migraine aura with diplopia or impairment of level of consciousness, hemiplegic migraine, or retinal migraine * has a current diagnosis of new persistent daily headache, trigeminal autonomic cephalgia (eg, cluster headache), or painful cranial neuropathy * required hospital treatment of a migraine attack 3 or more times in the previous 6 months * has a chronic non-headache pain condition requiring daily pain medication * has a history of malignancy in the prior 5 years, except for adequately treated basal cell or squamous cell skin cancer, or in situ cervical cancer * has a history of any prior gastrointestinal conditions (eg, diarrhea syndromes, inflammatory bowel disease) that may affect the absorption or metabolism of investigational product; participants with prior gastric bariatric interventions which have been reversed are not excluded * has a history of hepatitis within previous 6 months.
analysis of the molecular composition of tubal cilia in patients with or without ectopic pregnancy

Conditions: Salpingectomy; Hysterectomy; Primary Ciliary Dyskinesia; Ectopic Pregnancy

Summary: primary ciliary dyskinesia associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of mobility of sperm but very little data on the structure and function of tubal cilia in women

primary ciliary dyskinesia (dcp) is a rare genetic disease (1 in 15,000 individuals at birth), which manifests itself in chronic respiratory infections (bronchopneumopathies and rhinosinusitis type) associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of sperm mobility. however, there is very little data in the literature on the structure and function of tubal cilia in women with dcp. before considering a study of tubal cilia in patients with dcp, it seems necessary to specify in dcp patients or not dcp, the molecular and morphological composition of tubal cilia and to look for ciliary abnormalities in case of geu

Eligibility criteria:
inclusion criteria: * patients with scheduled salpingectomy (ectopic pregnancy, hysterectomy for prolapsus, adenomyosis or myomectomy) * major patients ( \>18 years) exclusion criteria: * patient not willing to participate in the study

Keywords: miscarriage tubal cilia
preoperative assessment and individualized operation optimization of acute ruptured cerebral aneurysms

Conditions: Printing, Three-Dimensional, Simulation Training

Summary: cerebral aneurysm is one of the main diseases that seriously affect human health. the most important treatment method is surgical clipping and endovascular embolization. not complete occlusion of the aneurysm is a main risk of recurrence and rebleeding after treatment. this study is focused on the 3d model of cerebral aneurysms and preoperative evaluation. combined with the 3d model, the neurosurgeon can complete the discussion of preoperative prediction of aneurysms and recognize the adjacent bone, blood vessels, aneurysm directions and so on. in addition, the model can also be used to the young doctor's training, and the patient and their families can be convenient and intuitive understanding of the disease, so as to form a good communication between doctors and patients.


Eligibility criteria:
inclusion criteria: * age: 18 years-80 years; * hunt-hess grade: 0-4; * without other stroke, brain trauma and other neurological disease; * without cerebral hernia; * cystic aneurysm. exclusion criteria: * age: less than 18 years or above 80 years; * hunt-hess grade is 5; * with serious previous disorder of multiple organ; * acute cerebral hernia; * aneurysms were fusiform or serpentine expansion.
comparative measurements of interface pressures between two pressure-ulcer prevention mattresses: softform premier and airsoft duo

Conditions: Pressure Ulcer

Summary: the main objective of this study is to compare the softform premier mattress (in static mode) and airsoft duo mattresses in terms of skin pressures measured at the sacral area.

the secondary objectives of the study are to compare the two devices in terms of: a. contact surface. b. heel pressure. c. on the occurrence of pressure ulcers anywhere on the body at month 1. d. patient comfort after 1 month (visual analog scale ranging from 1 to 10).

Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * the patient spends more than 12 hours in bed with a possible verticalization and a predictable length of stay of at least 1 month. * the patient has a stable medical condition (no complications in the last 10 days) without pressure ulcers * the patient is at risk of pressure ulcers assessed a score ≤ 14 on the norton scale * the patient's weight is less than 120 kg exclusion criteria: * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to sign the consent * it is impossible to correctly inform the patient * contra-indication for strict decubitus dorsal position * the patient has a rotation of the pelvis, asymmetric deformations of the hips in the frontal plane. * the patient has bedsores, a recent scar in a pressure area. * the patient has a knee flexion deformity\> 10 ° * the patient is agitated or uncooperative * the patient's weight is greater than 120 kg

Keywords: mattress preventing bed sores skin pressure
acute hemodynamic effects of sildenafil in patients with severe aortic stenosis

Conditions: Aortic Stenosis

Summary: pulmonary hypertension is common in patients with aortic stenosis and is associated with worse operative and long-term outcomes. sildenafil has been shown to reduce pulmonary artery pressure and improve exercise performance in patients with left-sided heart failure, but this has not been tested in patients with aortic stenosis. we hypothesize that sildenafil will produce a clinically significant decrease in pulmonary artery pressure in patients with severe aortic stenosis. the dose of sildenafil that produces a significant decrease in pulmonary artery pressure will be safe and well tolerated in patients with and without a depressed ejection fraction.

patients with severe aortic stenosis referred for a clinically ordered right and left heart catheterization will be eligible. twenty subjects will be enrolled: 10 patients will receive 40mg and 10 patients will receive 80mg; each dose will be equally distributed among those with preserved (≥50%) and reduced (\<50%) ef. subjects will get a baseline echo prior to the heart catheterization. baseline invasive hemodynamic measurements will be performed using a swan ganz catheter. a single oral dose of sildenafil will then be administered (40mg or 80mg), followed by invasive hemodynamic measurements at 30 and 60 minutes. also at 60 minutes, limited echocardiographic images will be obtained.

Eligibility criteria:
inclusion criteria: * severe aortic stenosis (ava \< 1.0 cm2) * referred for a clinically ordered right and left heart catheterization * 18 years of age and older * able and willing to comply with all requirements of the study exclusion criteria: * nitrate use within 24 hours * sbp \< 110 mmhg or map \< 75 mmhg * severe mitral regurgitation * severe aortic regurgitation * increased risk of priapism * retinal or optic nerve problems or unexplained visual disturbance * alpha antagonists or cytochrome p450 3a4 inhibitors use within 24 hours * current or recent (≤ 30 days) acute coronary syndrome * o2 sat \< 90% on room air * females that are pregnant or believe they may be pregnant * any condition which the pi determines will place the subject at increased risk or is likely to yield unreliable hemodynamic data * unwilling to provide informed consent

Keywords: aortic valve stenosis sildenafil phosphodiesterase inhibitors hypertension, pulmonary
research in the development of a new type of digital dermatoscope for skin cancer

Conditions: Skin Cancer; Skin Diseases

Summary: this is a multicenter prospective observational clinical investigation with a medical device. the purpose of this study is to develop and validate of a new type of digital dermatoscope with automatic decision support algorithms. by means of this study a better insight can be gained of the current performance and workflow in clinical dermatoscopy. this knowledge will be used to further improve the developed technology.


Eligibility criteria:
inclusion criteria: * the patient has a lesion that is accessible to the barco digital dermatoscope * patient gives informed consent * men or women of any ethnic group aged ≥ 18 years exclusion criteria: * men or women of any ethnic group aged \< 18 years * patients not willing or able to read, understand and sign the study-specific informed consent form
covid-19 and working conditions of dentists

Conditions: COVID-19; Dentistry

Summary: the aim of this study is to evaluate the protective measures and awareness of dentists working in turkey regarding the covid-19 pandemic.

within the scope of the study, patient care protocols in public and private health institutions during and after the pandemic, published on the website of the turkish dental association (http://www.tdb.org.tr/) a survey consisting of 35 open-ended and multiple-choice questions was prepared based on the updated directive titled. the questions directed to dentists in the prepared questionnaire are distributed as follows: * demographic information (6 questions), * physical conditions of the unit to be served (5 questions), * applications for employees (2 questions), * applications for appointment and patient admission (4 questions), * study procedure and treatment protocols (10 questions), * attitudes towards covid-19 (8 questions) existing questionnaire questions were examined by 5 dentists for clarity and finalized. a pilot study was conducted on a group of 20 dentists before the prepared questionnaire started to work. the reliability of the questionnaire was evaluated by retesting this group of 20 people 10 days later. 20 people included in the pilot study were evaluated within the scope of the study. survey questions were shared online. according to the data of the turkish dental association, survey questions were sent to the registered dentists in the chambers. before the survey questions appear on the screen, individuals will be informed of the privacy policy for data collection and consent to volunteering is asked. if they answered "no" to the survey, the survey was closed automatically. a second reminder email was sent to those who did not respond to the questionnaire four days later. a reminder e-mail was sent to those who did not respond to the questionnaire, six days after the start date.

Eligibility criteria:
inclusion criteria: * graduated from a dentistry faculty, * continuing or not continuing postgraduate dentistry education (master, specialty, doctorate), * working in a practice or outpatient clinic, private or public hospital, private polyclinic or state oral and dental health center or university hospital, * all dentists registered in dentistry database in turkey (37 cities) exclusion criteria: -

Keywords: covid-19 awareness dentistry pandemic protective measures
relation between ai-qca and cardiac pet

Conditions: Coronary Artery Disease; Coronary Artery Stenosis

Summary: the aim of the study is to evaluate the clinical implications of artificial intelligence (ai)-assisted quantitative coronary angiography (qca) and positron emission tomography (pet)-derived myocardial blood flow in clinically indicated patients.

percutaneous coronary angiography (cag) is a standard method for evaluating coronary artery disease. traditionally, a reduction in the luminal diameter of the coronary arteries by 50% or more during angiography has been considered a significant stenotic lesion. however, the assessment of coronary artery stenosis is usually based on visual estimation by the operator in daily routine clinical practice, which interferes with the objective evaluation. quantitative coronary angiography (qca) has been developed to overcome this limitation. this technique involves the software-based analysis of coronary images obtained through cag. the previous study showed that there was low concordance between the qca and visual estimation of coronary artery stenosis (kappa=0.63) and a reclassification rate of approximately 20%. furthermore, visual assessments tended to overestimate the degree of coronary artery stenosis, particularly in complex lesions such as bifurcation lesions. however, there are some limitations to adopting qca in our daily routine practice. the qca cannot analyze coronary images on-site and is not fully automated, requiring manual adjustments by humans. recent advancements have led to the development of artificial intelligence (ai)-based qca software, which achieves complete automation in the analysis process and provides real-time objective evaluations of coronary artery stenosis. this study aims to examine the clinical significance of ai-qca by assessing the correlation between the degree of coronary stenosis detected by ai-qca and myocardial blood flow abnormalities observed in 13nh3-ammonia pet scans in patients with coronary artery disease.

Eligibility criteria:
inclusion criteria 1. subject must be ≥18 years 2. patients suspected with cad or ischemic heart disease 3. patients undergoing cag and cardiac pet for evaluation of severity of coronary artery disease exclusion criteria 1. poor imaging quality of cag and pet which were not available for core-lab analysis 2. chronic total occlusion 3. time interval was more than \>3 months between cag and pet 4. history of coronary artery bypass grafting 5. history of acute myocardial infarction or recent myocardial infarction 6. heart failure (left ventricular ejection fraction \<40%)

Keywords: invasive coronary angiography cardaic positron emission tomography artificial intelligence quantitative coronary angiography
adjunct collection of additional biorepository data from patients enrolled in diabetic foot consortium (dfc) trials

Conditions: Diabetic Foot Ulcer

Summary: the biorepository will guide the diabetic foot consortium (dfc) activities for collection and storing biosamples and data from participants enrolled in other current and future dfc research studies.

participants enrolling in a parent dfc research study will be concurrently approached about participating in the dfc biorepository as well. if agreeable, participants will be asked to provide blood, urine, wound debridement tissue and wound dressing samples at the time of enrollment and once more if appropriate and as coincides with the primary study visit schedule. participants will also be contacted via phone for every six months for two years thereafter to gather longitudinal data about their wound. data and samples from the biorepository, along with data collected during the primary study will be available to ancillary researchers.

Eligibility criteria:
inclusion criteria: * provides written informed consent * stated willingness to comply with all study procedures and availability for the duration of the study * age \> 18 years * previous diagnosis of type 1 or type 2 diabetes or pre-diabetes per american diabetes association (ada) guidelines * inclusion in a part of any planned or approved dfc protocol exclusion criteria: * an individual who meets exclusion criteria of the primary dfc protocol in which they are enrolled will also be excluded from participation in the biorepository program as well.

Keywords: diabetes, diabetic foot ulcer, dfu, wound, wound healing