Kornimate/medical-research-clean huggingface dataset:
effects of (1,3), (1,6)-beta-d-glucan on insulin sensitivity and inflammatory markers of the metabolic syndrome

Conditions: Overweight

Summary: insoluble (1,3),(1,6)-beta-d-glucan from bakers yeast are indigestible polysaccharides. previous studies indicate that the intake of insoluble dietary fiber is strongly associated with reduced risk of type 2 diabetes and cardiovascular disease. however, the mechanisms leading to this phenomenon are largely unknown. there are close relations between metabolic and inflammatory pathways, and a number of hormones, cytokines, signal proteins, bioactive lipids, and transcription factors have been shown to be involved in both systems. beta-d-glucans have been suggested to play a role as so called biological response modifiers. studies in animals indicate that even small doses of (1,3),(1,6)-beta-d-glucan may have beneficial effects on immune activity, i.e., by reducing the secretion of inflammatory factors. the investigators hypothesize that the intake of isolated (1,3), (1,6)-beta-d-glucan from bakers yeast improves inflammatory makers and insulin-sensitivity in overweight subjects with increased c-reactive protein concentrations at baseline.


Eligibility criteria:
inclusion criteria: * healthy subjects with normal glucose tolerance (ngt) * impaired glucose tolerance (igt) * impaired fasting glucose (ifg) exclusion criteria: * any severe cardiac disease * liver * kidney diseases * type 1 or type 2 diabetes * chronical and acute inflammatory diseases * lipid lowering drugs * cortisone * antibiotics * non-steroidal antiinflammatory drugs * including low dose acetylsalicylic acid

Keywords: increased non-specific inflammatory markers
a phase iii study of entecavir vs lamivudine in adults with chronic hepatitis b infection and negative for hepatitis b e antigen

Conditions: Chronic Hepatitis B

Summary: the purpose of this clinical research study is to assess the safety and effectiveness of entecavir, as compared to lamivudine, in the treatment of adults with chronic hepatitis b infection who are hepatitis b e antigen negative.


Eligibility criteria:
* male and female subjects =/\> 16 years of age (or minimum age required in a given country) with history of chronic hepatitis b infection; * hbeag negative, anti-hbeab positive; * absence of coinfection with human immunodeficiency virus (hiv), hepatitis c virus (hcv) or hepatitis d virus (hdv); * absence of other forms of liver disease e.g., alcoholic, autoimmune, biliary disease; * less than 12 weeks prior therapy with nucleoside or nucleotide analogue antiviral agents with activity against hepatitis b (e.g., adefovir, famciclovir and lamivudine)
tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (tpop): tpop-01 study

Conditions: Trauma; Posttraumatic Stress Disorder

Summary: the purpose of this study is to evaluate the efficacy and safety of polyunsaturated fatty acid for the prevention of posttraumatic stress disorder (ptsd) in patients with accidental injuries.

accidental injuries, mostly motor vehicle accident, in civilian population are frequent events. for instance, nearly one-third of injured patients appear to develop trauma-related psychiatric illness and the major diagnoses are post-traumatic stress disorder (ptsd) and depressive disorder. omega-3 polyunsaturated fatty acid (omega-3 pufa) has some evidence of efficacy of treatment in patients with anxiety and mood disorders, but no evidence of preventing anxiety and mood disorders that occur subsequent to accidental injuries. we evaluate efficacy and safety of omega-3 pufa for the secondary prevention of posttraumatic stress disorder (ptsd) and related psychiatric illness in patients with accidental injury.

Eligibility criteria:
inclusion criteria: 1. 18 plus years 2. a native japanese speaking ability 3. possibility contact patients with injury in 240 hours, and dosing in oral use 4. physical and metal status to possible understands scope and contents in the trial and gets informed consent exclusion criteria: 1. clearly irretrievable acute brain parenchyma damage and subdural or subarachnoidal bleeding detected by computed tomography and/or magnetic resonance imaging 2. cognitive impairment: mini mental state examination \< 24 3. heavy drinker or 100iu/l ≦ γgtp in administration 4. heavy smoker (over 40 cigarettes per day) 5. history and current suspicion in diagnosis of psychosis and bipolar i disorder 6. suspicion in diagnosis of alcoholic, substance-related disorder and eating disorder 7. existence of marked serious symptoms such as suicidal ideation, self-harm behavior, dissociation, status of need rapidly psychiatric treatment 8. use of anti-epilepsy drug, lithium, ethyl icosapentate and anti-coagulant drug (for example, aspirin, warfarin, etc) within 3 month at regular intervals 9. use of polyunsaturated fatty acid supplement within 3 month at regular intervals 10. habit of eating fish over 4 times per week

Keywords: patients high-energy admitted intensive care unit motor vehicle accident falling from height other accident
l-carnitine on the prevention of renal scarring in acute pyelonephritis

Conditions: Acute Pyelonephritis(APN)

Summary: risk factors for parenchymal damage in urinary tract infection are vesicoureteral reflux (vur),obstructive uropathy,the number of flares of acute pyelonephritis(apn) and delay in treatment of acute infection.the pathogenesis of apn is related to bacterial virulenece,immune response,tissue factors,apoptosis and production of free radicals that lead to fibrosis and renal scarring. oxidative stress in renal cells may be a critical factor in the pathogenesis of pyelonephritis whereas pharmacological management of the oxidative stress response may provide a therapeutic effect in preventing renal pathologies. animal model show that l-carnitine alleviated oxidative stress, and acute renal inflammatory injury can be prevented much more effectively by carnitine in addition to conventional antibiotic treatment in pyelonephritis.this study is a simple randomized clinical trial (rct) evaluating the effect of l-carnitine in addition to antibiotic on preventing renal scaring after acute pyelonephritis in children. simple non- blind randomized clinical trial on 78 patients in 2 groups (intervention \& control) is conducted.children aged 1 month to 10 years with positive urine culture, clinical findings, and 99mtc-dimercaptosuccinic acid (dmsa) scintigraphy-based evidence in favor of acute pyelonephritis were enrolled into a clinical trial. patients were excluded if they had neurogenic bladder, systemic hypertension, obstructive uropathy. patients in intervention group are administered 50 mg/kg/day carnitine in divided 2-3 times/day (maximum 3 g/day) in addition to antibiotic regimens and patients in control group received antibiotic regimens. primary outcome is the development of renal scar by doing dmsa renal scan on the 7th day of admission and six months after the intervention and compared between groups and secondary outcome is the incidence and severity of pyelonephritis and response to treatment.


Eligibility criteria:
inclusion criteria: * children aged 1 month to 10 years with positive urine culture, clinical findings, and 99mtc-dimercaptosuccinic acid (dmsa) scintigraphy-based evidence in favor of acute pyelonephritis exclusion criteria: * neurogenic bladder, * systemic hypertension, * obstructive uropathy
long-term study of onabotulinumtoxina treatment in adult patients with upper limb spasticity

Conditions: Muscle Spasticity; Stroke

Summary: this is a long-term safety and efficacy study of onabotulinumtoxina in poststroke patients with upper limb spasticity.


Eligibility criteria:
inclusion criteria: * for patients entering from the 191622-127 study, successful completion of study 191622-127 * for patients entering directly into study 191622-129, upper limb spasticity in the elbow and shoulder due to stroke, with the most recent stroke at least 3 months ago exclusion criteria: * spasticity in the non-study upper limb that requires treatment * presence of fixed contractures in of the study muscles in elbow or shoulder * profound atrophy of muscles to be injected * previous surgical intervention, nerve block, or muscle block for the treatment of spasticity in the study limb in the last 12 months * injection of corticosteroids or anesthetics, use of casting or dynamic splinting or constraint-induced movement therapy (cimt) for the study limb within 3 months * ultrasound therapy, electrical stimulation, or acupuncture in the study limb within 1 month * condition other than stroke contributing to upper limb spasticity * diagnosis of myasthenia gravis, eaton-lambert syndrome, and/or amyotrophic lateral sclerosis
association between active transport and acute myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: this study aims to investigate the association between active transport and the incidence of acute myocardial infarction in england.

this is a cross sectional ecological study using aggregated data from the existing myocardial ischaemia national audit project between 2010 and 2013. data on active transport according to local authority was obtained from the uk 2001 and 2011 census, whilst important confounders including deprivation levels, prevalence of obesity and population smoking estimates were obtained from public health england. in addition to investigating the association between active transport and ami, we also studied the extent to which the components of active transport, cycling and walking, were associated with ami, and investigated whether any associations were contingent on a time lag effect between the dates of exposure to active transport and indecent ami.

Eligibility criteria:
inclusion criteria: * all cases of acute myocardial infarction recorded in minap between 2003 and 2010 exclusion criteria: * cases aged \ 64 years

Keywords: active transport cycling walking
prevalence of pulmonary embolism in patients with syncope

Conditions: Syncope; Pulmonary Embolism

Summary: all patients consecutively referred with the first episode of transient and short-lasting loss of consciousness will have a diagnostic workup for the assessment of the most common causes of syncope, and will be evaluated for the presence of pulmonary embolism (pe) with the use of an internationally accepted algorithm including a pre-test clinical probability (ptp according to the method of wells et al.) and a high-sensitivity quantitative d-dimer assay. if the ptp is low and d-dimer negative, pe will be excluded. all other patients will undergo confirmatory diagnostic tests (either computerized tomography or ventilation/perfusion lung scanning) in order to confirm or rule out the presence of pe.


Eligibility criteria:
inclusion criteria: * first episode of syncope exclusion criteria: * previous episodes of syncope * ongoing anticoagulation * age younger than 18 years * pregnancy

Keywords: syncope pulmonary embolism
cocoa polyphenols and postprandial metabolism in type 2 diabetes

Conditions: Type 2 Diabetes

Summary: this study aims to investigate the postprandial effects of cocoa supplementation in glucose and lipids, and surrogate markers of atherosclerosis in patients with type 2 diabetes. the investigators aim to test the hypothesis that cocoa will lower high-fat mixed meal breakfast-induced postprandial rise of glucose, lipids and markers of atherosclerosis in patients with diabetes. randomized cross-over controlled trial, in which participants will be assigned to the placebo or cocoa group with breakfast meal. patients with type 2 diabetes(n=25) will qualify for the study. the participants will be asked to consume 2 cups cocoa or placebo beverage on 2 separate postprandial study days. both groups will receive high-fat mixed meal breakfast on each day. blood draws and blood pressure (including hdi) measurements will be conducted at fasting, 30 min, 1,2, 4 \& 6 hours postprandial each day for 2 days.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of type 2diabetes exclusion criteria: * on insulin therapy

Keywords: diabetes cocoa polyphenols postprandial glycemia postprandial lipemia
long term (1 year) respiratory sequelae in children surviving an acute respiratory distress syndrome

Conditions: Acute Respiratory Distress Syndrome

Summary: the purpose of this study is to assess long term (1 year) respiratory sequelae in children surviving an acute respiratory distress syndrome

the acute respiratory distress syndrome (ards) has a high mortality rate in children. adverse long term sequelae, and in particular respiratory sequelae, have been described mainly in adults. decrease in diffusing capacity, lung volume and exercise tolerance were observed. lung function parameters improve during the follow-up until 6 month after discharge from the pediatric intensive care unit (picu). after that, abnormalities in pft are observed in a significant proportion of patients. only two studies described long-term sequelae in children surviving to an ards and their results are conflicting. two studies carried out in adults described the morphologic long-term sequelae by thoracic computed tomography. they showed reticular pattern with a striking anterior distribution in most patients evaluated more than 6 months after discharge from the picu. there is, to our knowledge, no study describing morphologic pulmonary sequelae by thoracic computed tomography in children surviving to ards. respiratory assessment: respiratory sequelae in children surviving to the acute respiratory distress syndrome will be evaluated 1 year after discharge from the picu. assessment will include a clinical evaluation (respiratory history and physical examination), respiratory function tests and thoracic computed tomography

Eligibility criteria:
inclusion criteria: * children surviving to an acute respiratory distress syndrome and alive 1 year after discharge from the picu exclusion criteria: * children suffering from neuromuscular disease * children presenting symptoms of chronic respiratory disease before ards

Keywords: acute respiratory distress syndrome children long term respiratory sequelae pulmonary function tests computed tomography, lung
genetic susceptibility to bladder cancer

Conditions: Bladder Cancer

Summary: this clinical research study will identify biologic and lifestyle factors which increase a person's risk of developing specific cancer. researchers propose to conduct a case-control study examining interindividual differences in susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. we will measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic modulation of carcinogen activation and detoxification and of chromosome sensitivity to tobacco mutagens.

researchers propose to conduct a case-control study examining interindividual differences in susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. we will measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic modulation of carcinogen activation and detoxification and of chromosome sensitivity to tobacco mutagens.

Eligibility criteria:
inclusion criteria: * subject has a histologically confirmed diagnosis of superficial or muscle-invasive bladder cancer * subject is a texas resident. * subject can understand english or a qualified translator is available for the interview. * subjects of any age, gender, or ethnicity are eligible to participate in the study. * subject consents to participate in the study. exclusion criteria: * subject has had prior treatment with systemic chemotherapy or radiotherapy in the past 6 months. * subject has been diagnosed with superficial or muscle-invasive bladder cancer more than twelve months ago.

Keywords: bladder cancer genetic susceptibility increased risk
accuracy of conventional and digital impression techniques used for maxillary hybrid prosthesis

Conditions: Prosthesis Durability

Summary: evaluation and comparison of the accuracy of conventional and digital impression for full arch screw retained prosthesis for edentulous maxilla.

each patient received 6 implants in the maxillary ridge (widely distributed across the arch) in the following positions: central incisors, canines/first premolar teeth and first molar teeth aided by surgical stent. then each patient received 2 types of impression techniques technique 1 :conventional impression conventional open tray impression technique with splinted transfers using vinylpolysiloxane and technique2 : digital impression taken using original scan bodies torqued to the implants .three dimensional accuracy of impression techniques was evaluated using linear measurements and 3d deviation between the two techniques was measured.

Eligibility criteria:
inclusion criteria: * the patients were selected according to the following inclusion criteria: 1. completely edentulous maxillary and mandibular ridges 2. healthy ridge covered by normal oral mucosa and free from any ridge flabbiness. 3. all of the patients were dissatisfied with the retention and stability of their maxillary conventional dentures and expressed a strong desire for a more stable prosthesis. 4. sufficient bone quantity and quality in the front and posterior maxillary regions, as determined by preoperative cbct, to accommodate six implants with a diameter of at least 3.5 mm and a length of at least 10 mm. 5. enough restorative space (from the mucosa covering the crest of the maxillary residual ridge to the occlusal plane) to allow the fixed prosthesis to be constructed ,preliminary jaw relationship revealed this. 6. it's been at least a year since the last extraction. exclusion criteria: 1. systemic diseases that may alter tissue response to implantation and affects osseointegration (radiation, diabetes, osteoporosis, bleeding disorders or hepatic patients) 2. long term immunosuppressive and corticosteroid drug therapy. 3. patient with abnormal habits as clenching and bruxism. 4. smoking patients. 5. patients with problems in tmj. 6. neuromuscular diseases.

Keywords: digital impression, conventional impression
nutritional intervention in geriatric oncology

Conditions: Cancer; Undernutrition; Aging

Summary: older patients with cancer are poorly treated or not treated at all. a previous study in the south west of france (364 patients) showed that patients receiving chemotherapy had short survival times which strongly depended on nutritional status. in this study, the researchers would like to evaluate if individual dietician follow-up at each cycle of chemotherapy increases survival of patients at risk of undernutrition.

undernutrition in patients with cancer also called tumour cachexia concerns about 50% of this population during tumour progression. it's well established that loss of weight is poor prognosis factor in patients treated by chemotherapy in digestive cancers. small number of studies assessing undernutrition, its management and consequences on prognosis were published. previous study lead by our team in oncogeriatry in aquitaine accrued 364 patients more than 70 years old and treated by chemotherapy for cancer. median follow-up at 13 months for intermediary analysis about 155 first patients revealed at first geriatric evaluation, 28 pts (18.7%) were malnourished (mna\<17) and 72 pts (48.0%) at risk of malnutrition (mna 17 to 23.5). at one year median follow-up major mortality was observed in 20 (71.4%) undernourished patients, 34 (47.2%) patients at risk of undernutrition and 13 (26.0%) patients without nutritional problem. according to consensus undernourished patients received nutritional support. management of patients at risk of malnutrition is not clear. our hypothesis is that nutritional support in patients at risk of undernutrition detected during geriatric evaluation could increase survival, safety, functional status and quality of life of patients. we construct an open multicentric two group randomized trial comparing usual nutritional management versus usual nutritional management plus nutritional intervention with dietician at each cycle of chemotherapy in 6 first cycles to maintain 30 kcal/kg/d and 1.2 protein/kg/d. principal objective is to increase survival at 1 year with 10%. according to o'brien and fleming method we have to include 410 pts in each group, about 1640 pts will be evaluated by mna test.

Eligibility criteria:
inclusion criteria: * over 70 years of age * histologically proven cancer * treatment by chemotherapy * risk of undernutrition according to mna score between 17 and 23.5 * ecog ≤ 3 * life expectancy \> 12 weeks * patient affiliated with the french social security regimen * written informed consent exclusion criteria: * mna score under 17 or over 23.5 * geographic, psychological, or social conditions potentially hampering compliance with the study protocol * symptomatic central nervous system (cns) metastases * chemotherapy treatments not published as standard protocols * treatment that does not allow geriatric evaluation and dietician follow-up.

Keywords: cancer elderly malnutrition chemotherapy survival comprehensive geriatric assessment morbidity
tunisian clinical registry on chronic kidney disease in hypertensive patients

Conditions: Chronic Kidney Diseases; Hypertension

Summary: in tunisia, high blood pressure (htn) is a public health problem whose prevalence varies from 28.7% to 34.7%. hypertension can be both, cause and consequence of chronic kidney disease, and its prevalence is quite high in this population. it is both a risk factor for mortality and cardiovascular morbidity, but also a major cause of terminal chronic kidney disease becoming an additional public health concern. detecting and diagnosing chronic kidney in all hypertensives at an early stage remains a global public health challenge. a well-conducted treatment makes it possible to reach the blood pressure objective but also to reduce the risk of occurrence of a cardiovascular event and to slow the progression of chronic kidney disease. in tunisia, few data exists concerning the prevalence of chronic kidney disease in hypertensive subjects, thus limiting the development and elaboration of preventive measures. a national survey will thus be conducted by the "kidney and metabolic diseases" working group under the aegis of the tunisian society of nephrology, dialysis and kidney transplantation. the main objective is to estimate the prevalence of chronic kidney disease in hypertensive tunisian patients.

this is national multicentric cross-sectional survey. the study will be carried out for one month at medical departments and ambulatory clinics of general physicians, family medicine specialists, endocrinologists, specialists in nutrition and metabolic diseases, nephrologists, internal medicine physicians, cardiologists, all physicians caring for non-diabetic hypertensive patients or any healthcare providers in charge of hypertensive patients. a steering committee helps investigators to monitor their patient inclusions, performs audit trails and prepares the statistical analysis plan for the study. collected data are managed by the dacima clinical suite®, the electronic data capture platform which complies with the fda 21 cfr part 11 requirements (food and drug administration 21 code of federal regulations part 11), the hipaa specifications (health insurance portability and accountability act), and the ich standards (international conference on harmonisation).

Eligibility criteria:
inclusion criteria: * confirmed hypertension * follow-up at consultation at least for three months before enrollment date * informed consent exclusion criteria: * hypertension emergency * pregnancy * kidney transplanted subjects * dialysis stage