Kornimate/medical-research-clean huggingface dataset:
neuroinflammation in ftld

Conditions: Corticobasal Syndrome(CBS); Primary Progressive Aphasia(PPA); Progressive Supranuclear Palsy(PSP); Behavioral Variant Frontotemporal Dementia (bvFTD); Frontotemporal Lobar Degeneration (FTLD)

Summary: the goal of this observational study is to investigate the role of neuroinflammation in frontotemporal lobar degeneration (ftld). the main aims of this study are: 1. to elucidate the role and timing of neuroinflammation in ftld by using a combination of clinical measures, 7t mri, and csf biomarkers; 2. to differentiate ftld-tdp and ftld-tau during life using biomarkers for neuroinflammation; 3. to identify biomarkers to predict and monitor disease progression in ftld; secondary aim: 1. to explore the role of brain clearance in the disease process of ftld. participants will undergo 7t mri scans, blood and csf collection, clinical, neurological, and neuropsychological evaluation.

at baseline, the study will involve the following procedures: clinical assessment including neurological and neuropsychological investigation, blood sampling, and a voluntarily lumbar puncture on the first day at the erasmus mc university medical center, (emc) and two sessions of 7t mri scanning on the second day at the leiden university medical center (lumc). after one year, clinical assessment and blood analyses will be repeated in the emc to assess disease progression. the aim is to include 25 patients with probable or definite ftld-tau, 25 patients with probable or definite ftld-tdp, 50 healthy individuals with 50% risk to carry a mutation in mapt or grn, or the c9orf72 hre. if necessary for age matching, 10 additional healthy subjects without increased risk of ftld will be included.

Eligibility criteria:
inclusion criteria: * ability to undergo mri scanning * for probable ftld-tau: a clinical diagnosis of psp, cbs or nfvppa, or any clinical ftld spectrum diagnosis with a proven mapt mutation * for probable ftld-tdp: a clinical diagnosis of svppa or any clinical ftld spectrum diagnosis with a proven grn mutation or c9orf72 repeat expansion * for presymptomatic mutation carriers: a mapt mutation, grn mutation or a c9orf72 mutation without clinical sign of a ftld spectrum phenotype (cdr 0) for control subjects: no known neurological or psychiatric disorder * for controls: no known neurological or psychiatric disorder exclusion criteria: * other neurological or psychiatric disorder that may affect cognitive functions, such as a brain tumour, multiple sclerosis or drug or alcohol abuse or use of psycho-active medications * csf profile (β-amyloid, p-tau, t-tau) suggestive of ad pathology * clinical dementia rating scale (cdr) score \>1 * contra-indication to undergo mri * contra-indication to undergo lumbar puncture

Keywords: frontotemporal lobar degeneration iron accumulation 7t-mri neurodegeneration neuroinflammation qsm csf blood mrs dmrs
experience in borderline ovarian tumors

Conditions: Borderline Ovarian Tumor

Summary: borderline ovarian tumors (bots) comprise 15-20% of primary ovarian neoplasms and represent an independent disease entity among epithelial ovarian cancers. the present study aimed to report the 8-year experience of a single center on the management and outcomes of consecutive bots patients. from january 2010 to december 2017, all patients with bots undergoing surgical treatment were included. demographic, clinical, and pathological data were reviewed retrospectively.


Eligibility criteria:
inclusion criteria: * age \> 18 years, * patients affected by borderline ovarian tumors (bot) of any histological type and any figo stage, * women undergoing surgical treatment with both laparoscopic and laparotomic approaches. exclusion criteria: - women affected by ovarian cancers

Keywords: conservative surgery micropapillary patterns surgical staging
survival analysis: tace vs. combination therapy in hcc

Conditions: Hepatocellular Carcinoma

Summary: this retrospective observational study aimed to assess potential improvements associated with systemic therapies in patients receiving transarterial chemoembolization (tace) for initially unresectable hcc.

standard treatments provide limited benefits for patients with intermediate or advanced hepatocellular carcinoma (hcc). recently, recommendations on multimodal treatment regimens for patients with locally advanced hcc have attracted much attention. therefore, this retrospective research was designed to evaluate the clinical outcomes of tace alone or in combination with immune and targeted therapy in the primary treatment for patients with intermediate to advanced stage hcc.

Eligibility criteria:
inclusion criteria: 1. both sexes, aged 18-75 years old; (2) hcc was clinically or pathologically diagnosed according to the american association for liver diseases (assld) criteria; (3) one or more tumor lesions could be measured according to modified response evaluation criteria in solid tumors (mrecist) on enhanced ct or mri; (4) for patients with barcelona clinic liver cancer (bclc) stage b or stage c hepatocellular carcinoma (hcc) in barcelona, and who are not suitable for surgical resection, it is recommended to undergo transarterial chemoembolization (tace) or combination therapy involving tace as the initial treatment; (5)child-pugh grade a or b, no hydrothorax, ascites and hepatic encephalopathy requiring treatment; (6) eastern cooperative oncology group performance status (ecog-ps) score 0-1; (7) have enough liver and kidney function in patients with appropriate laboratory indicators: hemoglobin concentration (hgb) hemoglobin, acuity 9.0 g/dl, neutrophils acuity 1500 cells/mm3, plt 50 \* 109 / l, or serum propagated 28 g/l, or tbil\< 50umol/l, alt, ast\< 5 times the upper limit of normal, bun, cr\< 1.5 times the upper limit of normal, inr\< 1.7 or pt prolongation \< 4s exclusion criteria: 1. other malignant tumors outside hcc, such as liver metastasis of colon cancer; (2) child-pugh grade c; (3) contraindications to tace, lenvatinib or tislelizumab; (4) any active autoimmune diseases or autoimmune disease, thyroid function hyperfunction or decline, which is to be bronchodilator treatment of asthma; (5) there are serious complications, including serious heart, lung, kidney, blood coagulation dysfunction; important cardiovascular diseases such as heart disease of the definition of new york heart association level 3 or higher, instability during the treatment of myocardial infarction, arrhythmia, unstable angina, etc; (6) past history of patients with idiopathic pulmonary fibrosis , machine pneumonia (e.g., occlusive bronchiolitis), drug pneumonia, idiopathic pneumonia or chest ct screening to find evidence for an active pneumonia; (7) patients with previous allogeneic stem cell or solid organ transplantation, including patients after liver transplantation; (8) clinical data absence or incomplete information.

Keywords: hepatocellular carcinoma transarterial chemoembolization combination therapy survival
pilot study of the effect of lactulose on post caesarean section constipation

Conditions: Constipation; Abdominal Pain; Nausea; Vomiting

Summary: constipation following elective caesarean sections (cs) is a common problem experienced by up to 50% of patients (1). the causes for this are multifactorial and include manipulation of the bowel during surgery, immobilisation and opiate based anaesthetic and analgesic techniques. to try to alleviate the problem of postoperative constipation, some anaesthetists prescribe postoperative lactulose in addition to postoperative analgesia, although no data exists that shows whether this has any beneficial effect on postoperative constipation. 1. short term morbidity associated with caesarean delivery. hillan em. birth. 19 (4): 190-4).


Eligibility criteria:
inclusion criteria: * all patients aged 16 years or older able to give informed consent undergoing their first or second elective cs exclusion criteria: * unable to give informed consent * a basic level of literacy sufficient to complete postoperative form. * history of constipation * regular opiate use * previous bowel surgery or bowel adhesions * lactose intolerant * diabetic * any patient unable to have spinal anaesthesia * allergies/intolerant to bupivacaine, diamorphine, diclofenac, cocodamol, lactulose * patients receiving injury to bowel intraoperatively * patients receiving additional opiates perioperatively

Keywords: constipation caesarean section abdominal pain nausea vomiting
thoracotomy closure technique and postoperative pain study: a randomized controlled trial

Conditions: Hernia; Lung Cancer

Summary: the purpose of this study is to examine pain associated with thoracotomy (incision made during surgery to obtain access to your thoracic cavity) and how the closure technique may influence postoperative pain. two types of routinely selected thoracotomy closure techniques will be examined; pericostal and intracostal sutures. the investigators hypothesize that intracostal sutures will result in less postoperative and chronic pain as a result of less compression of the intercostal nerve.


Eligibility criteria:
inclusion criteria: * patients undergoing an elective procedure that will include a thoracotomy. * all patients will undergo epidural catheter placement. exclusion criteria: * previous thoracotomy on the operative side. * previous history of chronic chest pain. * previous history of thoracic trauma on the operative side. * less than 18 years of age * inability to provide informed consent or to complete testing or data collection * need for a chest wall resection * patients requiring other incisions in addition to a thoracotomy (i.e., laparotomy, sternotomy

Keywords: thoracotomy pain intracostal suture pericostal suture
ketamine + cognitive training for suicidality in the medical setting

Conditions: Suicide, Attempted

Summary: this project seeks to identify the acute and longer-term impact of a single dose of intravenous ketamine among suicidal patients referred for psychiatric consultation/liaison in the medical inpatient setting. the investigators will then test whether ketamine's rapid effects can be extended by introducing helpful information delivered by a computer-based training protocol. this work could ultimately lead to the ability to treat suicidality more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.

note: edits were made to the outcome measures sections to improve clarity regarding the a priori analytic plan with respect to the "time frame" of measurements and to reduce redundancies. timepoints that will be analyzed as trajectories over windows of time and measurements that will be analyzed as composites are now more clearly specified. the previous entries correctly identified all relevant measures and timepoints, but implied incorrectly that each timepoint/measure would be analyzed in isolation.

Eligibility criteria:
inclusion criteria: participants who receive ketamine will: 1. be between the ages of 18 and 70 years 2. be a medical inpatient referred for psychiatric consultation/liaison due to suicidality and determined by psychiatric c/l to require follow-up psychiatric care (inpatient or outpatient) 3. possess a level of judgment and understanding sufficient to agree to all procedures required by the protocol and must sign an informed consent document 4. be deemed an appropriate and reasonable medical candidate for intravenous ketamine by a physician authorized to prescribe medication to the patient during inpatient hospitalization exclusion criteria: 1. presence of current/acute psychosis with significant thought disruption, mania, delirium, or dementia, or a diagnosis of developmental disorder with significant language and/or intellectual impairment 2. mini-mental state exam (mmse) \< 21 3. current pregnancy or breastfeeding 4. reading level \<5th grade as per wrat-3 reading subtest and patient declines to have all questionnaire items and task instructions read aloud to them at all assessment points 5. past intolerance or hypersensitivity to ketamine or esketamine 6. patients taking st john's wort 7. patients who have received ect in the past 1 month prior to intake 8. patients at ongoing risk for severe substance or alcohol withdrawal related issues (e.g., delirium tremens, severe opiate withdrawal) or who present with substance-induced psychosis 9. arrested or incarcerated individuals brought in by the legal system for medical stabilization
enpowering progression risk of cerebral amyloid angiopathy

Conditions: Cerebral Amyloid Angiopathy; CAA - Cerebral Amyloid Angiopathy

Summary: cerebral amyloid angiopathy (caa) is a microangiopathy characterized by the progressive deposition of β-amyloid in cerebral vessel walls, contributing to intracerebral hemorrhages, cognitive decline, and other clinical manifestations. despite recent advances in diagnosis and understanding, many pathogenic, prognostic, and therapeutic aspects remain unclear. study objective: priority is a prospective observational study aimed at identifying clinical, neuroradiological, and biochemical biomarkers that could improve early diagnosis, risk stratification, and the identification of personalized therapeutic targets for caa.

priority is a prospective, single-center observational study conducted at the fondazione irccs istituto neurologico carlo besta in milan. it will consecutively enroll patients over 18 years of age with possible or probable cerebral amyloid angiopathy (caa), symptomatic or asymptomatic, with or without histological confirmation. diagnosis will follow the updated boston criteria 2.0, and a brain mri is mandatory for inclusion. the study duration is 36 months, with clinical and neuroimaging assessments at baseline (t0), 12 months (t1), and 24 months (t2). csf analysis will be performed at t0; plasma biomarkers (via elisa and simoa) will be assessed at all time points. lipid profiles will be analyzed using mass spectrometry with both untargeted and targeted lipidomic approaches (e.g., sphingolipidomics). the comprehensive clinical and biological dataset will be used to develop a machine learning-based predictive model to support diagnostic, prognostic, and therapeutic decision-making in caathe study duration is 36 months, with clinical and neuroimaging assessments at baseline (t0), 12 months (t1), and 24 months (t2). csf analysis will be performed at t0; plasma biomarkers (via elisa and simoa) will be assessed at all time points. lipid profiles will be analyzed using mass spectrometry with both untargeted and targeted lipidomic approaches (e.g., sphingolipidomics).

Eligibility criteria:
inclusion criteria: * patients of either sex over 18 years of age; * patients with possible and probable symptomatic or asymptomatic caa with or without histological demonstration (modified boston criteria); * patients who have had at least one brain mri. exclusion criteria: * patients who have contraindications to undergoing brain mri (e.g., pacemaker, incompatible mechanical valves, claustrophobia); * patients who have contraindications to or refuse to undergo lumbar puncture; * patients who are unable to provide informed consent for the study due to aphasic or cognitive impairment; * patients who are pregnant or breastfeeding.

Keywords: cerebral amyloid angiopathy caa plasma biomarkers cerebrospinal fluid biomarkers
the effect of motivational interviewing and education based on watson's theory of human caring in hemodialysis

Conditions: Renal Disease; Adherence, Treatment; Quality of Life; Satisfaction, Patient

Summary: * motivational interviewing and education based on watson's theory of human caring have an effect on increasing adherence to fluid intake in individuals receiving hemodialysis treatment. * motivational interviewing and education based on watson's theory of human caring have an effect on increasing adherence to diet in individuals receiving hemodialysis treatment. * motivational interviewing and education based on watson's theory of human caring have an effect on increasing adherence to drug management in individuals receiving hemodialysis treatment. * intervention group who receiving motivational interviewing and education based on watson's theory of human caring would satisfied with introduced intervention. * motivational interviewing and education based on watson's theory of human caring have an effect on increasing quality of life in individuals receiving hemodialysis treatment.

the intervention group received 15 minute motivational interviewing based on watson's theory of human caring once a month for 12 weeks and one session 30 minutes education with educational booklet based on watson's theory of human caring. the control group received usual care. adherence to fluid intake, diet and drug management, physical parameters and quality of life was measured at baseline and 12th week. the patient satisfaction was measured in the intervention group at 12th week.

Eligibility criteria:
inclusion criteria: * patients who were receive hemodialysis at hemodialysis unit of university hospital in antalya, turkey * patients who had 1 and above from diet and fluid non-adherence questionnaire total score * patients who had 0 or 1 score from 1.2. and 6. questions or 3., 4. and 5. questions in the modified morisky scale. * patients who receiving hemodialysis treatment for at least 3 months * patients who were over 18 years of age, * patients who had orientation of individual, place and time * patients who were literate * patients who no barriers to written or verbal communication * patients who agree to participate in the study exclusion criteria: * patients who had psychiatric disease * patients who had diagnosis of malignancy

Keywords: compliance motivational interviewing models, nursing nursing patient satisfaction quality of life randomized controlled trial renal dialysis
cognitive health awareness program in surgical patients

Conditions: Dementia; Cognitive

Summary: addressing brain health and cognitive impairment (ci) in the aging population is important, especially in those undergoing surgery. while certain adverse outcomes are beyond control due to various factors, some may be preventable, such as delirium. it is crucial for patients and their families to be fully aware of the heightened risks associated with ci. by discussing the implications for individuals and their families, patients can make informed decisions about their health. additionally, patients can be better prepared for their post-operative care and informed about post-operative complications. education is a practical and viable solution to promote awareness and empower individuals to manage their cognitive health, especially in the context of surgery. also, it can act as an early intervention. thus, there is a need to proactively educate older adults about brain health. the objective of the web-based brain health education study is to determine the impact of preoperative education on the knowledge of cognitive health of older surgical patients. specifically, our study will examine the changes in knowledge scores after patients participate in a web-based education program on promoting brain health during their surgical journey. we hypothesize that a web-based education program will increase patient knowledge and empower them proactively about their brain health during the surgical journey.

the primary objective of this study is to determine the impact of a web-based educational program in promoting brain health in older surgical patients by changes in their knowledge score after education. for the secondary objectives, we aim to 1) determine participant satisfaction with the educational program, and 2) gain insights regarding perceived benefits and drawbacks of the brain health program. this multicenter study will target older patients from pre-admission clinics at toronto western (twh) and mount sinai hospitals (msh). written informed consent to participate in the study will be obtained from all patients in person during the visit. in a pre-operative assessment 1-30 days prior to their scheduled surgery, patients will be asked to participate in our web-based educational program. the program will be delivered on a research laptop/ipad at the clinic. the entire program, including pre- and post-education questionnaires and satisfaction survey should take about 20 minutes to complete.

Eligibility criteria:
inclusion criteria: * patients ≥60 years old * undergoing elective non-cardiac surgery * competent to provide informed consent in english and * possess some computer skills exclusion criteria: * previous major neurocognitive disorder * uncontrolled psychiatric disorders * hearing and/or vision impairment

Keywords: educational program cognitive impairment postoperative delirium
efficacy and safety of extracorporeal biofeedback

Conditions: Female Stress Urinary Incontinence

Summary: stress urinary incontinence is the most common type of female incontinence. the efficacy of pelvic floor muscle training with biofeedback has been already proved in many studies. but intravaginal probe is one of the limitation. so, the purpose of this study is to assess the efficacy and safety of extracorporeal biofeedback device with pelvic floor muscle training.


Eligibility criteria:
inclusion criteria: * women with stress urinary incontinence * standard pad test \> 2gram exclusion criteria: women with: * mixed urinary incontinence of which urgency incontinence is dominant * true incontinence * overflow incontinence * treatment within 14 days preceding screening, or expected to initiate treatment during the study with electrostimulation, bladder training * treatment within 7 days preceding screening, or expected to initiate treatment during the study with oab medication or other medication which affect bladder function * pelvic organ prolapse which the stage is at least 2 * proven urinary tract infection during screening period * pacemaker * pregnant women * neurogenic voiding dysfunction

Keywords: pelvic floor muscle training extracorporeal biofeedback
chest x-ray in diagnosis of heart failure

Conditions: Chest X-ray ; Heart Failure

Summary: the objective of this study is to compare the performance of x-chest ray in the diagnosis of acute cardiac insuficiency through the interpretation of a senior and a non-senior.

acute cardiac insufficiency (ica) is a leading cause of acute dyspnea in the emergency department (su) and is associated with a higher risk of morbidity and mortality. an increasing number of tools for better ica diagnosis are available in the sus. however, there is likely room to improve the ica diagnostic approach using widely available routine tools, including chest x-ray . chest x-ray is a rapid and inexpensive method that is routinely performed in an emergency in patients with acute dyspnea. this is the first-line diagnostic imaging modality recommended in the guidelines. the objective of this study is to compare the performance of x-chest ray in the diagnosis of acute cardiac insuficiency through the interpretation of a senior and a non-senior. a senior emergency physician or resident and an intern, perform a reading of chest x-ray in any included patient by answering to following questions: is there cardiomegaly? calculation of the cardio-thoracic index is there a vascular distribution towards the vertices, if so is it uni or bilateral? is there pleurisy, if so is it uni or bilateral? is there an interstitial syndrome, if so is it uni or bilateral? is there an alveolar syndrome, if so if so is it single or bilateral? is the diagnosis of heart failure very likely, likely or unlikely? then there will be a comparison of the two answers.

Eligibility criteria:
inclusion criteria: * age over 18 all dyspnea acute non-traumatic a resident or intern in medicine and a senior are available to read chest x-ray within 24 hours of admission exclusion criteria: * age under 18 * post traumatic dyspnea * patient not requiring hospitalization * mechanical ventilation from the start * cardio-respiratory arrest * pregnant woman * and any patient who cannot achieve reproducibility within 24 hours of admission.

Keywords: chest x-ray heart failure diagnosis senior non-senior