Kornimate/medical-research-clean huggingface dataset:
posture correction exercises for forward head posture in chronic smartphone and laptop users

Conditions: Forward Head Posture

Summary: this study aims to compare different posture correction exercises to see which is most effective in improving forward head posture (fhp) in people who frequently use smartphones and laptops. fhp occurs when the head leans forward, putting extra strain on the neck and shoulders, leading to discomfort and pain. with the increasing use of digital devices, many individuals experience posture-related issues without realizing their long-term effects. this study will assess the impact of specific exercises, such as chin tucks and neck isometric holds, in realigning the head and relieving discomfort. the research will involve 56 participants aged 18-40 who use their devices for at least 2-3 hours daily. participants will perform targeted exercises over four weeks, and improvements in posture and pain levels will be measured using a standardized scale. the study aims to determine whether structured posture correction exercises can help alleviate fhp and improve overall well-being in frequent digital device users.

this study focuses on understanding and improving forward head posture (fhp), a common problem seen in people who frequently use smartphones and laptops. fhp occurs when the head moves forward beyond its natural alignment, causing excessive strain on the neck, shoulders, and upper back. it can lead to pain, stiffness, headaches, and long-term postural problems. with the increasing use of digital devices, more people-especially young adults-are experiencing fhp without realizing its impact on their health. this study aims to compare different posture correction exercises to determine which is most effective in reducing fhp and associated discomfort. people often use smartphones and laptops for long hours without paying attention to their posture. research shows that prolonged device use can cause poor posture habits, leading to musculoskeletal issues over time. if left untreated, fhp can contribute to chronic neck pain, reduced mobility, and even long-term spinal problems. this study is important because it will help identify simple exercise-based solutions that can improve posture and reduce discomfort. the findings can benefit smartphone and laptop users by promoting awareness and encouraging healthy posture habits.

Eligibility criteria:
inclusion criteria: * participants falling in this category would be recruited into the study. * demographic criteria; age from 18-40 years both male \& female. * smartphone usage for minimum of 2-3 hours daily from last one year * willingness to participate. * no previous treatment for forward head posture. exclusion criteria: * participants who fall in this category would be excluded of the study. * spinal deformities * spinal injuries * existing neurological conditions * pregnancy due to possible posture changes.

Keywords: forward head posture (fhp)
safety study of rufinamide given as an add-on therapy to treat patients with seizures

Conditions: Refractory Partial Seizures

Summary: this study will evaluate the efficacy and safety of rufinamide in reducing seizure frequency in subjects with partial seizures not fully controlled despite treatment with 1 to 3 concomitant antiepileptic drugs.


Eligibility criteria:
inclusion criteria: * male and female patients between 12 and 80 years of age * dx of epilepsy with partial onset seizures woth or woth out secondarily generalized seizures * non controlled partial seizures despite treatment with 2 different aeds for at least 2 years * must have 6 seizures during baseline * current treatment with maximum of 3 aeds * stable dose of aed(s)for at least 1 month * if patient has vns, must have been implanted 6 months prior to randomization exclusion criteria: * participation in any investigational product for at least 1 month prior to visit 1 * presence of non-motor simple partial seizures only * presence of generalized epilepsies * evidence of clinically significant disease * clinically significant ecg * psychogenic seizure in previous year * history of drug/alcohol abuse * history of suicide attempt * multiple drug allergies * concomitant felbamate use * need for frequent rescue benzodiazepines * concomitant use of vigabatrin * all patients diagnosed with congenital short qt syndrome

Keywords: seizure, seizures, epilepsy
oct agreement and crossed precision study

Conditions: Glaucoma; Retinal Disease; Corneal Disease

Summary: the purpose of this study is to asses the agreement of the rs-3000 lite and rs-3000 advance to the rs-3000, assess the crossed precision of each study device and to assess the transference of a reference database from the rs-3000 to the rs-3000 lite and to the rs-3000 advance.


Eligibility criteria:
inclusion criteria: normal eyes * subjects who do not have pathology in both eyes inclusion criteria: glaucoma * subjects who have a glaucoma diagnosis inclusion criteria: retinal * subjects who have a retinal diagnosis including but not limited to: 1. diabetic macular edema 2. dry age related macular degeneration 3. wet age related macular degeneration 4. cystoid macular edema 5. epiretinal membrane 6. macular hole inclusion criteria: corneal * subjects who has one of these diagnosis: 1. post status lasik surgery 2. keratoconus 3. other corneal dystrophies or degenerations. exclusion criteria: all eyes * subjects who have any of the following conditions 1. diabetes mellitus (dm) and/or diabetic retinopathy 2. uncontrolled hypertension (ht) 3. cerebral infarction, cerebral hemorrhage, cranial nerve neoplasm and other central nervous system diseases affecting vision 4. cardiac, hepatic, renal and hematologic diseases 5. a current condition requiring systemic administration of steroid 6. a history of, or currently receiving, anticancer therapy 7. epileptic seizures which are optically induced 8. dementia * subjects who have other life threatening and debilitating systemic diseases note: additional criteria may apply

Keywords: normal eyes eye; disorder with glaucoma eye; disorder with retinal disease eye; disorder corneal disease incl kerato-refractive group
clinical decision support system (cadims) for ms diagnostic

Conditions: Multiple Sclerosis, Relapsing-Remitting

Summary: 1. background the results obtained in clinical research led to a new paradigm for the treatment of patients affected with multiple sclerosis (ms): "no evidence of disease activity". this means having each patient monitored with high quality imaging. to this purpose, researchers have developed segmentation algorithms for automated reading of mris, facilitating longitudinal comparisons, and allowing an accurate assessment of the number and the volume of focal lesions. we have thus a powerful strategic biomarker for the treatment of ms. due to the relevance of comparing over time the evolution of lesions (lesion load) and brain atrophy, the french society of neuroradiology edited standardized national recommendations. the ms french observatory (ofsep) has adopted these recommendations, in order to harmonize exams for all patients all over the country. at an international level as well, mri have been put at the heart of the therapeutic strategy. therefore, we need now to create the conditions able to implement, collect and analyze imaging data according to these recommendations. this is the meaning of the music project, which aims to develop and assess a standardized monitoring mri control tool for therapeutic decision. cadims is this tool. it is based on an integration of several segmentation algorithms developed by inria and an image viewer developed by b\ com and included in a regional images-sharing server etiam nexus. this tool is a help showing segmented brain t2 lesions, gadolinium-enhanced t1 lesions and news t2 lesions appeared from the previous mri exam, in a multicenter clinical context. 2. objective to evaluate the accuracy of ms lesions detection on cerebral mri by comparing the cadims tool to the expert consensus.


Eligibility criteria:
inclusion criteria: * ≥ 18 years-old * patient with relapsing-remitting multiple sclerosis, according to the 2010 mc donald's criteria * edss\<4 * disease duration \< 10 years * to insure a clinical demand of 2 brain mris within 12 months of the installation of an immunomodulatory therapy * mri brain scanner acquired according to the ofsep recommendations installation of an immunomodulatory therapy exclusion criteria: * progressive ms * no consent of the patient

Keywords: multiple sclerosis, relapsing-remitting, computer-assisted diagnosis, mri, diagnosis, treatment efficacy
metabolic phenotyping in anorexia nervosa

Conditions: Anorexia Nervosa

Summary: after discharge from inpatient treatment, 30-50% of patients with anorexia nervosa require re-hospitalization within 4-12 months. so far, high relapse rates are mostly considered as lack of the patient's compliance and motivation to recover. however in studies, psychological relapse predictors explain only a minor part of the variance in relapse risk. metabolic phenotyping has clinical value to predict weight course in obese patients and we assume that it could also be clinically relevant in patients with an. we hypothesize that in patients with a dissipative but not with the thrifty phenotype, positive energy balance during refeeding causes an over proportional rise in energy expenditure, counteracts continuous weight gain during inpatient treatment, and increases relapse risk within one year after discharge. thus we believe that metabolic phenotype as a biological parameter has prognostic value for the disease course in an.


Eligibility criteria:
inclusion criteria: * diagnosis of anorexia nervosa * between 12 and 18 years of age * written and informed consent of patient and parents * mental ability to understand the concept of the study * inpatient admission to charité university clinic with body weight below the 10th bmi-percentile exclusion criteria: * any further disease other than an with significant influence on body composition and energy metabolism or its assessment
characterization of clinical skeletal and cardiac impairment in carriers of dmd and bmd

Conditions: Duchenne Muscular Dystrophy; Becker Muscular Dystrophy

Summary: longitudinal prospective observational study. this is a 24-month study with the possibility of extending the data time points. initially baseline, then 12 and 24 months follow up studies will be completed.

four cohorts are enrolled in this study. the target population is the cohort of genetically confirmed dmd/bmd female carriers (cohort a). this cohort will consist of 150 dmd/bmd mothers who are somatic carriers of a mutation in the dmd gene. the data collected for this cohort will be compared to three control groups; control group b is a cohort of 50 dmd/bmd mothers who are not somatic carriers, control group c is a cohort of 50 age-matched healthy controls and control group d is a cohort of 25 genetically confirmed carriers who do not have an affected child. the inclusion of a control group b allows for a comparison to a group of mothers that share the emotional and cognitive burden of caring for an affected male without having the physical or cognitive risks of being a female carrier. the control group c offers robust data from an age-matched healthy cohort for purposes of comparison. control group d allows for comparison to a group of women that have the same physical or cognitive risks as the cohort a female carriers, but do not have the same burden of care giving.

Eligibility criteria:
inclusion criteria: * age \>18 years * cohort a requires a genetically confirmed mutation in the dmd gene with an affected child * cohort b includes dmd/bmd mothers with no somatic mutation in the dmd gene * cohort c age-matched healthy controls with a normal ck level * cohort d requires a genetically confirmed mutation in the dmd gene without an affected child * able to complete testing in english * able to consent exclusion criteria: * subjects with a contraindication to cardiac or skeletal muscle mri * subjects on heart failure medication at time of enrollment * subjects on steroid treatment * presence of an inherited neurologic disease or comorbidity that may affect their ability to complete this study * has a medical condition or extenuating circumstance that, in the opinion of the investigator, might compromise the subject's ability to comply with the protocol required testing or procedures or compromise the subject's wellbeing, safety, or clinical interpretability
atac - quality of life sub-protocol

Conditions: Quality of Life

Summary: to compare quality of life between the arimidex group, the nolvadex group and the arimidex plus nolvadex combination group during the first two years of treatment. (a) to compare the difference in quality of life between the arimidex group and the nolvadex group (b) to compare quality of life in the arimidex plus nolvadex combination group with the nolvadex group for non-inferiority; if non inferiority is concluded, the difference in qol between these two groups will be assessed.


Eligibility criteria:
inclusion criteria: * eligible for entry into the main atac trial 1033il/0029 * completion of a baseline questionnaire exclusion criteria: * excluded from entry into the main atac trial (1033il/0029) * if, in the investigators opinion, the patient would be unable to comply with this sub-protocol due to psychiatric or literacy reasons
the effectiveness of massage in treating constipation

Conditions: Constipation

Summary: the purpose of this study is to compare the effectiveness of massage based on the tensegrity rule and classical abdominal massage in persons with constipation.

constipation can be defined as "an embarrassing ailment of the 21st century". it affects about 20-25% of the population, women as well as men, but occurs more frequently in women (female:male ratio of 2.2:1). persons of different age suffer from it. constipation is a bothersome ailment which negatively affects the general physical and mental state, lowers physical and mental fitness, significantly hinders professional work, and decreases life comfort as the factors which contribute to the occurrence of constipation are very diverse and complex, the treatment is a long-term and slow process. there are numerous conservative treatment methods for constipation, such as physical treatments, reflexotherapy, biofeedback, pharmacotherapy, and modification of lifestyle. there is also a possibility of applying classical massage in persons with constipation. however, observations of the authors suggest it is not a therapy commonly applied.

Eligibility criteria:
inclusion criteria: 1. age from 18 to 70 years old 2. after therapy with vermoks 2\*1/ 3 regardless of body weight 3. negative elis test for lambliasis 4. proper laboratory tests results: bilirubin, fa, ggtp, aspat, alat 5. ultrasound scan of the abdominal cavity 6. positive interview based on questionnaire exclusion criteria: 1. present cancer or prior cancer treatment, if there is no clear agreement of the involved oncologist 2. renal insufficiency \> ii nyha 3. cardiovascular problems 4. respiratory insufficiency \> ii degree gold 5. unstable coronary disease 6. hypertensive crisis 7. liver insufficiency 8. prior liver transplant 9. prior or active hepatitis 10. jaundice 11. prior surgical treatments except: appendectomy \>5 years before, cholecystectomy 5 years before 12. unequalized endocrinopathies 13. metabolic storage diseases 14. diabetes 15. nephrolithiasis 16. cholelithiasis 17. pancreatitis 18. chronic diseases of the intestines 19. diseases of the muscles 20. pregnancy 21. parasite infections of the digestive system (infection with human roundworm, lambliasis) 22. age above 18 years old 23. bmi\> 33 24. improper ultrasound scan result or laboratory tests results 25. blood presence in feces

Keywords: constipation massage tensegrity
the effectivness of fodmap diet in israel in relieving symptoms of patients with irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: treatment of ibs is very problematic. despite the wide range of pharmacological and non-pharmacological therapies, there is no universally accepted approach. in recent years, the low fodmap diet has been developed, a dietary approach that aims to relieve the symptoms of ibs. fodmaps (fermentable oligosaccharides, di-saccharides, mono-saccharides and polyols) are a group of dietary sugars that may be poorly absorbed in the small intestine and fermented by bacteria to produce gas. ingestion of fodmaps may also result in alterations in fluid content in the colon and trigger functional gut symptoms in some individuals. this study aims to examine the effectiveness of the fodmap diet in israel in improving symptoms of ibs compared to the standard dietary advice.


Eligibility criteria:
inclusion criteria: 1. fulfillment of the rome iii criteria for ibs. 2. aged 18-77 years at the time of screening. 3. provision of written informed consent. 4. commitment of availability throughout the 10 week study period. 5. availability of at least one gi imaging study during the last 5 years (colonoscopy, sigmoidosopy, abdominal ultrasonography, barium enema) for subjects older than 50 years. exclusion criteria: 1. major abdominal surgery in the past. 2. the presence of any active (organic) gi disease. 3. past or present major medical or psychiatric illness. 4. any concomitant disease. 5. alarming symptoms (rectal bleeding, weight loss, etc.) 6. pregnancy. 7. family history of colorectal carcinoma or ibd, under the age of 50. 8. abnormal laboratory studies (blood biochemistry, liver enzymes, complete blood count), abnormal thyroid function. 9. non-adjusted diet in the case of lactose or gluten intolerance. 10. recent travel to regions with endemic parasitic diseases.
postoperative pain after root canal disinfection via diode laser

Conditions: Root Canal Infection; Pain

Summary: the prevention and control of post-treatment pain is of great importance for the comfort of the patient as well as for the clinician's prestige. in this study, the effect of 940 nm diode laser disinfection on the postoperative pain of retreatment cases was evaluated.

from the fact that microorganisms are the most common factors causing pain, this study aimed to evaluate effect of 940 nm diode laser disinfection performed in addition to conventional irrigation on postoperative pain of retreatment cases. eighty-four patients with chronic apical periodontitis were treated. root canal fillings were removed using rotary files. root canals were irrigated using sodium hypochlorite between instrument changes. final irrigation was performed using sodium hypochlorite and ethylenediaminetetraacetic acid (edta). the cases were randomly allocated into 2 groups: group 1: diode laser disinfection group, group 2: control group. root canal fillings were applied and crowns were restored. all treatments were completed in a single appointment. patients were given a pain scale and they were requested to mark the code that reflects their pain intensity during 3 days.

Eligibility criteria:
inclusion criteria: * only asymptomatic single rooted teeth that had an initial root canal filling diagnosed with chronic periodontitis (minimum size 2x2 mm) exclusion criteria: * teeth with root canal fillings newer than 4 years, overfilled teeth, teeth with intraradicular posts, existence of a sinus tract, consumption of antibiotics within 1 month, consumption of analgesics in last 5 days, systemic disease, pregnancy, history of trauma, traumatic occlusion

Keywords: postoperative pain diode laser retreatment
effect of mother's push at cesarean delivery mother's pushing at cs a randomized controlled trial

Conditions: Caesarean Section; Mother-Child Relations; Post Operative Pain; Postpartum Depression

Summary: the purpose of this study is to assess the safety and efficacy of the mother's active pushing during cesarean delivery.

patients, who are getting a scheduled cesarean section and having no contraindication for valsalva manoeuvres are eligible for this study. the gestational week should be between 37 and 42 weeks. patients have to provide informed consent to this study. patients must have epidural anaesthesia. they must understand the german language in order to understand information during cesarean section and correctly fill-out the questionnaires. emergent cesarean sections or pregnant women known with chronic pain, severe preeclampsia or hellp-syndrome will be excluded. 179 patients were initially recruited, of which 79 were excluded. the 100 patients were grouped into two study groups; conventional and assisted groups. the grouping was performed randomly using simple randomization. based on the findings of armbrust et al and our clinical experience we expect a therapeutic effect of 20% which results in a mean visual analog scale reduction of 1.2. applying a two-sided t-test for independent samples at a significance level of 0.05, a mean difference of 0.8 between the groups and a standard deviation of 2, we need 17 patients per treatment arm to detect a difference between both treatment groups with a power of 80%14. the number of patients per treatment arm was increased to 50 patients to make up for any missing data.

Eligibility criteria:
inclusion criteria: * minimum age of 18 years * written consent * pregnant women between 37 - 42 weeks * no fetal abnormalities. * scheduled primary c-section (category 3\&4 nice guidelines) with epidural anaesthesia exclusion criteria: * emergent cesarean section * contraindication for epidural anaesthesia. * multiple pregnancies * scheduled c-section with placenta previa, accreta, increta or percreta. secondary c-section * contraindication for valsalva manoeuvre * known psychiatric illnesses * known chronic pain, taking pain killers regularly * language barrier
post-marketing study for the evaluation of profilm mouth sores

Conditions: Mouth Sores

Summary: the study aims to assess the effect of profilm mouth sores treatment for relieving symptoms caused by mouth sores. it will involve 35 participants and last around 14 days or until the sores heal, with three daily applications. a dermatology specialist will evaluate the results through tests and examinations of the treated area.


Eligibility criteria:
inclusion criteria: * male / female / aged 18 years or older. * presence of an ulcer on the oral mucosa, regardless of the number of days since its appearance. * at least 30 days have passed since the last episode. * willingness to return for all study-related visits. * sufficient willingness and ability, as judged by the investigator, to respond to the questionnaires included in the study. exclusion criteria: * pregnant women or women in the breastfeeding period. * patients undergoing treatment with antiviral medications, hydrocortisone, or other medications. * patients with immunodeficiency diseases, such as acquired immunodeficiency syndrome or altered immune activity in the last 7 days. * patients undergoing other pharmacological therapy for oral conditions. * patients with other oral mucosa diseases simultaneously. * known allergy or hypersensitivity to any of the components.

Keywords: ulcers recurrent aphthous stomatitis oral ulcers mouth ulcers mouth sores sore