Kornimate/medical-research-clean huggingface dataset:
indoor air quality for black adults with uncontrolled asthma

Conditions: Asthma

Summary: the aims of this project are twofold: 1. to characterize indoor air quality components obtained from apartments with gas stoves and open kitchens in a cohort of black adults with uncontrolled asthma recruited from federally qualified health centers and enrolled in the parent study. 2. to conduct a comprehensive assessment of feasibility, implementation, and acceptability of the study.

people spend as much as 90% of their time indoors, making indoor air quality (iaq) particularly important to health. many homes in new york city, particularly low-income housing, contain gas kitchen appliances, which generate fuel through the combustion of natural gas, generating indoor pollutants. increasing evidence finds that even low levels of these pollutants are hazardous for human health. those most vulnerable to ambient air pollution live in homes with gas appliances and inadequate ventilation. moreover, individuals with pre-existing diseases like asthma are particularly susceptible to adverse health effects from poor iaq, which gas stoves may exacerbate. this study addresses the important problem of uncontrolled asthma among a group at high risk for asthma and its adverse effects - black adults who reside in homes with gas stoves and open kitchens. the investigator aims to characterize indoor air quality components in a cohort enrolled in the parent r01 (nct05341726) and conduct a comprehensive assessment of feasibility including process, implementation and acceptability metrics. identifying new targets for asthma self-management that could produce better health outcomes, thus addressing an important health inequity issue.

Eligibility criteria:
inclusion criteria (participants): patient participants will 1. be adults (\> or = 18 years of age) 2. self-report race as 'black' race (african american, african, caribbean, west indian, multi-racial \[black and one or more additional races\]); identify their ethnicity as hispanic or non-hispanic 3. have clinician-diagnosed persistent asthma (defined as being prescribed inhaled corticosteroids in the last 48 months) or have had an asthma exacerbation (e.g., er visit, course of prednisone) regardless of controller medicine use 4. receive asthma care at a partner federally qualified health center and 5. screen positive for uncontrolled asthma as measured by the asthma control questionnaire- 6 items (acq-6) and erroneous beliefs as measured by the conventional and alternative management for asthma (cam-a) survey. exclusion criteria (participants): 1. non-english speaking or 2. serious mental health conditions that preclude completion of study procedures or confound analyses

Keywords: asthma bronchial diseases respiratory tract diseases lung diseases, obstructive lung diseases respiratory hypersensitivity hypersensitivity, immediate hypersensitivity immune system diseases greenhouse effect air pollution, indoor
fitness, activity and lung cancer study

Conditions: Lung Cancer

Summary: the purpose of the study is to investigate the change in pulmonary function and exercise capacity in lung cancer patients after pulmonary resection. furthermore, to study the effect of training on aerobic capacity, muscular strength, morbidity and survival. physical activity level by accelerometers, body composition by dxa and quality of life will also be reported.

five year after surgery, all included patients will be reinvited to undergo a fourth health excame to study the long-term effects of exercise training on physical fitness, morbidity and survival.

Eligibility criteria:
inclusion criteria: * non smal cell lung cancer * patient living in oslo or akershus county and accepted for lung cancer surgery at oslo university hospital and akershus university hospital * were able to read and speak norwegian exclusion criteria: * mental incompetence or physical disability that makes it difficult to walk on a treadmill * treatment or medical complications affecting ability to participate in an exercise group * \> 79 years

Keywords: pulmonary function maximal oxygen uptake cardiorespiratory fitness high-intensity training surgery
acute anterior or posterior cerebral artery occlusion recanalization therapy and relationships with clinical outcome (acapulco)

Conditions: Ischemic Stroke; Thrombi

Summary: nearly 3% of patients with ischaemic stroke (is) have an isolated occlusion of the anterior or posterior cerebral artery in the acute phase of the disease. in those patients, intravenous thrombolysis (it) is indicated for 4.5 hours after symptoms onset. due to a lack of data, mechanical thrombectomy (mt) is not considered as a gold standard to treat is alone or in addition with it. therefore, observational studies are needed to understand the clinical evolution of patients with is treated with it and/or mt. the acapulco retrospective observational study aims to highlight potential benefits of mt in those patients to improve their management and to propose targeted therapies in the future.


Eligibility criteria:
inclusion criteria: * age ≥ 18 and \< 96 * clinical signs consistent with acute ischemic stroke * patients who presented within 6 hours of stroke symptoms onset * isolated occlusion of the anterior or the posterior artery exclusion criteria: * administration of recanalization treatment before hospital admission
brief evidence-based psychological treatments for emotional disorders

Conditions: Anxiety Disorders; Depression; Somatoform Disorders; Common Mental Disorders

Summary: the present work aims to develop a randomized clinical trial with a sample of 165 patients diagnosed with an emotional disorder. all participants are tested by several self-reports related to common mental disorders in a repeated measures design, pre and post treatment as well as a six month follow up. we think this study will demonstrate that brief psychological treatments should be prioritized over pharmacological treatment for such pathologies in the primary or secondary care context to improve the patient´s quality of life while simultaneously reducing costs.

nowadays, the heavy demands placed on health systems exceed the resources in many developed countries. so-called "common mental disorders" and their mostly pharmacological treatment are, in no small part, responsible for this situation. the cost that these disorders generate to the public health service is very high and they are usually associated with other issues like hyperfrequentation and side effects. however, research indicates that psychological treatment should be the first step when caring for these types of problems. we expect that the results show that extensive psychological therapy and combined treatment were the most effective. nevertheless, brief psychological treatment is expected to be the most efficient in cost-benefit terms.

Eligibility criteria:
inclusion criteria: * emotional disorders exclusion criteria: * severe mental disorder * drug abuse * severe depression

Keywords: common mental disorders brief psychological treatments primary care randomized clinical trial
the difference of angle of femoral component rotation in tka with gap balance and measured resection technique

Conditions: Osteoarthritis, Knee

Summary: gap balance type and measured resection type total knee arthroplasty (tka) have different influence on the rotation of femoral component.in this study, the rotation of patients received different type of tka will be estimated and analysed through preoperation and postoperation knee joint ct scan.

this is a multicenter, double-blined, randomized controled clinical trial. 98 patients from 2 clinical center will be recruited with primary knee osteoarthritis, undergoing a primary tka. the patients will be randomly divided into two groups , the measured resection group and the gap balance group.and the gap balance technique in this study will be achieved with a ligament tensor used during tka. femoral component rotation will be assessed from the preoperative and postoperative ct scans.

Eligibility criteria:
inclusion criteria: * severe primary osteoarthritis patients over 65 years old no obvious surgical contraindications exclusion criteria: * there are surgical contraindications varus or valgus alignment exceeds 20 degrees

Keywords: total knee arthroplasty ct scan
testing spectrosense eva system for detection of pancreatic cancer by analyzing volatile organic compounds (vocs) in exhaled air

Conditions: Pancreatic Cancer

Summary: volatile organic compounds (voc) in human breath are captured and analyzed by the spectrosense eva system, which is combination of a gas chromatography (gc) and software algorithm. the objective is to obtain a set or sets of voc bio-markers that will provide the best discrimination between pancreatic cancer sick population and healthy population. the gold standard for identifying sick/healthy population is biopsy proven pancreatic cancer.


Eligibility criteria:
pancreatic cancer group inclusion criteria: * age from 18 years old * pancreatic cancer positive biopsy * before any treatment * signed informed patient consent exclusion criteria: * age under 18 years old * neoadjovant treatment * post surgery for pancreatic cancer * a history of any other cancer type, except skin cancer that is not melanoma healthy group inclusion criteria: * healthy patients * no history of pancreatic cancer * signed informed patient consent exclusion criteria: * history of pancreatic cancer * pancreatic cancer background in the family * a history of any other cancer type, except skin cancer that is not melanoma
ultrasound guided pectoral nerves blockade for persistent pain after breast cancer surgery

Conditions: Persistent Pain After Breast Cancer Surgery

Summary: this is a pilot study of the pectoral nerves block (pecs) in patients with persistent pain after breast cancer surgery.

this study is in 2 parts: part 1 is a description of the anatomy of the pecs block in pain free, unoperated patients using ultrasonography (non invasive). part 2 is the administration of the block to patients that have persistent pain after breast cancer surgery. before and after the block we will take a detailed pain history and do neurophysiological tests called quantitative sensory testing (qst). these tests assess the patients' ability to feel warmth, cold and test their thresholds for pain. the block is then administered using ultrasound guidance and 20mls of 0.25% bupivacaine is injected in the pectoral muscles on the side with pain. thirty minutes after the block, the pain is re assessed and the qst is repeated.

Eligibility criteria:
inclusion criteria: * female patients, aged 18 years or over, treated for breast cancer * patients with persistent pain in the breast after surgical treatment for breast cancer. their pain score must be 4 or more on the numerical rating scale (nrs). exclusion criteria: * breast surgery within the last 12 months * previous cosmetic surgery * bilateral breast cancer (receiving bilateral intervention) * pregnant or breast feeding * neurological disease * on-going treatment for severe mental illness or who abuse alcohol or drugs * are unable to understand written or spoken danish or english * lack mental capacity to give informed consent or cooperate with the neurophysiological testing * an allergy to amide local anaesthetics * pacemaker in situ * received treatment outside guidelines and recommendations from the danish breast cancer co-operative group (dbcg)

Keywords: anesthetics, local mastectomy neuralgia nerve block
application of percutaneous electrolysis, percutaneous neuromodulation and eccentric exercise

Conditions: Supraspinatus Tendinitis

Summary: the supraspinatus muscle tendinopathy show a big impact, however, there is a lack of awareness about the options of the physiotherapist treatment. it is necessary to do studies about effectiveness of therapeutic percutaneous electrolysis (epte®). this technique enables treatment of the tendinopathies and the broken muscle fibrilare. it is base on the application of galvanic current through a acupuncture needle. to analyze the effectiveness of therapeutic percutaneous electrolysis (epte®) in the treatment of supraspinatus muscle tendinopathy. single center randomized controlled trial, parallel treatment design. a specialist physician will be diagnosed the supraspinatus muscle tendinopathy. participants will be randomly assigned to receive treatmen for 4 weeks: epte® associated with eccentric exercises or dry needling with the same eccentric exercises. both interventions were performed under ultrasound guidance with a portable ultrasound (general electric logice). data will be collected by a blinded evaluator.

eccentric exercises of the supraspinatus muscle were performed in 3 sets of 10 repetitions. participants were asked to perform the exercise program on an individual basis twice every day for 4 weeks. the eccentric program consisted of 3 exercises, focusing on the supraspinatus, infraspinatus, and scapular muscles. participants were asked to do a normal abduction (concentric phase) and a slow return to the initial position (eccentric phase) included first the concentric phase, and the eccentric phase was slowly conducted. the exercise program was taught by a physiotherapist in the first session and monitored in the subsequent sessions.

Eligibility criteria:
inclusion criteria: * patients diagnosed with supraspinatus tendinopathies that do not improve with conventional physiotherapy or pharmacological therapy protocols. * subjects who are in an active state of pain, who present painful symptoms in a sensitive and painful area of the tendon of insertion of the supraspinatus muscle in the humerus. exclusion criteria: * individuals who have received surgery intervention in the same shoulder, or have suffered fractures or dislocations in the same shoulder. * individuals have received the proposed treatment in one month´s period previously. * individuals who suffering from cervical radiculopathies, fibromialgia síndrome, cardiac patients with pacemakers, cancer, infectious processes, or generalized lymphedema. * pregnant women can not receive this treatment intervention.

Keywords: tendinopathy electrolysis exercise dry needling
immediate vaginal reconstruction after oncologic resection: surgical outcomes, patient satisfaction and sexual function

Conditions: Vaginal Cancer

Summary: this study is being done to find out more about the experience women have with vaginal reconstruction. we hope to learn about their quality of life, sexual function, and body image. we would like to find out how happy women are with surgery. we also want to know what things should be changed or improved. since you have had this surgery, we would like to ask you to take part in an interview.

the purpose of this study, entitled immediate vaginal reconstruction following oncologic resection: surgical outcomes, patient satisfaction and sexual function is to determine postoperative complications, patient satisfaction, quality of life and level of sexual functioning among patients who have undergone vaginal reconstruction following tumor resection and/or pelvic exenteration.this study will have three components: 1) a chart review to determine postoperative complications and anatomic characteristics of the neo-vagina, 2) a postoperative questionnaire consisting of validated survey instruments to assess quality of life, body image and sexual function and 3) a postoperative qualitative interview to examine quality of life after vaginal reconstruction.

Eligibility criteria:
inclusion criteria: * immediate partial or total vaginal reconstruction with myocutaneous or fasciocutaneous flaps, following pelvic exenteration or tumor resection at mskcc during the study period from january 1, 1993 to, march 30, 2007. exclusion criteria: * none

Keywords: vaginal reconstruction
prospective study of belated pulmonary complications occurring in children treated with allogeneic hematopoietic stem cells.

Conditions: Bone Marrow Transplant Infection; Bronchiolitis Obliterans; Chronic Respiratory Insufficiency; Organizing Pneumonia; Pulmonary Cytolytic Thrombi

Summary: hematopoietic stem cell transplantation (hsct) is used to treat an expanding array of malignant and non-malignant disorders. this is a prospective multicenter study, in pediatric allo-bmt recipients to analyze the spectrum of noninfectious pulmonary complications (pc), to evaluate the prevalence and course of pft abnormalities before and after transplant, and to detect risk factor for pc.

it's a multicenter prospective study in france. all children under 18 years are included, just before the hsct. the functional test before the hsct at 6, 12, 18, 24, 30 and 36 months will be collected and a cardiopulmonary exercise test is done one and three years after the hsct. thoracic tomodensitometry is done before the hct and after at 6, 12, 24 and 36 months. all data will be collected upon the hsct, the infections before and after the hsct, the respiratory symptoms, and the treatment. bronchia alveolar lavage and serum will be collected and frozen during the study. the inclusion will be done during two years and children will be following during three years. the purpose is to evaluate the prevalence, the course of pft abnormalities before and after transplant, and to detect risk factor for pc.

Eligibility criteria:
inclusion criteria: * age: from birth to 18 years * patient to be treated by allogeneic hematopoietic stem cell - parents who have given their signed consent for the study * affiliation to a social security scheme exclusion criteria: * non exclusion criteria

Keywords: non infectious pulmonary complications after hematopoietic cell transplant functional respiratory test and exercise test thoracic tomodensitometry
intravenous milk thistle (silibinin-legalon) for hepatic failure induced by amatoxin/amanita mushroom poisoning

Conditions: Amatoxin Poisoning; Amanita Poisoning; Mushroom Poisoning; Liver Failure

Summary: legalon® sil will be administered to patients with amatoxin poisoning diagnosed by history, gastrointestinal symptoms, elevated liver enzymes, and/or diagnostic assay (should one become available). patients may or may not also demonstrate abnormalities in bilirubin and/or creatinine. treatment consists of a 5 mg/kg loading dose followed by 20 mg/kg/day via continuous infusion. the treating physician is expected to administer supportive therapy of his/her choosing but consistent with best practices. legalon® sil will be stopped when coagulopathy is no longer present, and when liver function tests have returned significantly towards the normal range. patients will be followed 7-14 days after the end of legalon® sil therapy with follow up lab studies.

patients with suspected amatoxin poisoning are reviewed for enrollment in the study by contacting the legalon sil study hotline (866) 520-4412.

Eligibility criteria:
inclusion criteria: 1. signed informed consent(s) for clinical trial participation (due to the potential critical status of the subject upon presentation, consent may need to be obtained from legally authorized representative (lar) per sites consenting policy and ich/gcp guidance) signed informed consent for clinical trial participation 2. history of eating foraged mushrooms 3. gastrointestinal symptoms suggestive of amatoxin poisoning (cramping abdominal pain, nausea, vomiting, and / or watery diarrhea) usually 24-48 hours after of mushroom ingestion 4. liver function tests suggestive of amatoxin poisoning: ast or alt above the institutions upper limit of normal after mushroom ingestion exclusion criteria: 1. evidence of significant medical illness or any other abnormal laboratory finding that, in the investigator's judgment, will substantially increase the risk associated with the subject's participation in, and completion of the study or could preclude the evaluation of the subject's response.

Keywords: amatoxin amanita mushroom poisoning hepatic failure milk thistle silibinin legalon
atezolizumab combined with chemotherapy in extensive stage sclc

Conditions: Small Cell Lung Cancer

Summary: clinatezo cohort will evaluate overall survival, real world progression-free survival, best response and duration of treatment in patients with advanced, metastatic small cell lung cancer (sclc) who received atezolizumab combined with chemotherapy part of the french early access program (atu). subsequent treatments (treatment delivered immediately after treatment with atezolizumab and chemotherapy) will be recorded. those outcomes will be correlated to clinical, pathological, and radiological characteristics of patients.

standard-of-care first-line treatment for advanced, metastatic small cell lung cancer is platinum chemotherapy (carboplatin or cisplatin) with etoposide. despite response rates of 60 to 65%, limited progress has been made in more than two decades; outcomes remain poor, with a median overall survival of approximately 10 months. small cell lung cancer has a high mutation burden, which suggests that these tumors may be immunogenic and could respond to immune-checkpoint inhibitors. atezolizumab is a humanized monoclonal anti-programmed death ligand 1 (pd-l1) antibody that inhibits pd-l1-programmed death 1 (pd-1) and pd-l1-b7-1 signaling and restores tumor-specific t-cell immunity. the addition of atezolizumab to chemotherapy in the first-line treatment of advanced, metastatic small cell lung cancer has been granted access for patients in france part of an early access program (atu), in may 2019.

Eligibility criteria:
inclusion criteria: * patients with histologically or cytologically confirmed extensive stage small cell lung cancer at time of initiation of treatment with atezolizumab and chemotherapy. * patients who were informed about the study and accepted for their data to be collected. * patients who received at least one dose of treatment with atezolizumab and chemotherapy as part of the french early access program (atu program) and have been accepted within this atu program * selection period spans from may 6th 2019 until january 31st 2020 for initiation of treatment with atezolizumab and chemotherapy. exclusion criteria: * patients enrolled in a clinical trial assessing treatment with a combination of atezolizumab and chemotherapy. (atu was granted to patients unable to meet eligibility criteria for on-going recruiting trials, unable to participate to other clinical trials, or because other medical interventions were not considered appropriate or acceptable). * patients who were included in the french early access program (atu program) but did not receive any atezolizumab and chemotherapy treatment.

Keywords: small cell lung cancer atezolizumab ifct real-world study