Kornimate/medical-research-clean huggingface dataset:
blinding and previous experiences of dry needling

Conditions: Neck Pain

Summary: dry needling (dn) is a treatment technique widely used in patients with various musculoskeletal health problems due to myofascial trigger points (mtrp). dn has shown to have positive effect on pain and function in patients with mechanical neck pain. these positive results are thought to be the consequence of specific neurophysiological and mechanical processes. research has shown that dn induces 1) end plate inhibition, 2) reduction of inflammatory substances, 3) increase of blood flow and oxygen and 4) a reduction of nociceptive afferent activity. however, the exact working mechanisms underlying dn effects is still a topic of debate. this trial addresses one of the major methodological issues in needle testing,the effects of proper blinding. dn is a specific technique that is not easily be replaced by another comparable intervention. a sham needle with a blunt tip was created that simulates penetration into the skin without actually doing so. research about a valid method for the control in needling studies is for this reason of particular relevance. a proper blinding technique is of importance to further the field of dn.

the objectives of this study are to analysize short-term effects on pain intensity and pressure pain sensitivity according to previous experience (blinding) in subjects with mechanical neck pain receiving real or sham-dn and to determine the success in masking dn versus sham dn in patients with mechanical neck pain based on prior experience with this technique.

Eligibility criteria:
inclusion criteria: * non-specific mechanical neck pain of at least 3 months of duration * between 18-60 years old * at least one active trigger point in the upper trapezius muscle which referred pain reproduces the neck pain symptoms exclusion criteria: * whiplash injury; * previous cervical or thoracic surgery; * cervical radiculopathy or myelopathy; * diagnosis of fibromyalgia syndrome; * having undergone physical therapy in the previous 6 months; * fear to needles

Keywords: dry needling placebo myofascial pain syndrome blinding
efficacy of parasternal blocks in cardiovascular surgery patients undergoing median sternotomy

Conditions: Postoperative Pain

Summary: acute and chronic pain after cardiac surgery is a common problem that negatively affects quality of life. postoperative pain after cardiac surgery is most intense in the first two days and decreases in the following period. however, postoperative pain with incomplete management in the acute period may become chronic. this may negatively affect the patient's quality of life. although central blocks such as thoracic epidural and paravertebral blocks are considered the gold standard in analgesia control, the advantages of thoracic plan blocks, which are more superficial due to peroperative heparinisation; coagulation disorders; and procedural difficulties, are undeniable. thoracic plane blocks, which can also be used in patients receiving anticoagulant and/or antiplatelet therapy, have recently been used for acute pain. the aim of this study was to evaluate the effect of thoracic plane blocks on extubation time, pain scores, intensive care unit (icu) and hospital stays in patients undergoing median sternotomy.

the study will proceed in three arms. the first group is the control group and will receive total intravenous anaesthesia as infusion after peroperative induction until the patient leaves the operating room. the second group will receive ultrasound-guided parasternal superficial plan block after induction. the third group will receive ultrasound-guided parasternal deep plan block. extubation times, additional analgesic needs, pain scores, intensive care unit duration and hospital discharge times will be compared in the three groups during intensive care unit follow-up. after extubation, patient-controlled analgesia will be applied for 24 hours (with pca infusion pump device).

Eligibility criteria:
inclusion criteria: * performing median sternotomy * elective case * over 18 years of age; under 80 years of age * asa ii-iii patients exclusion criteria: * emergency cases * patients undergoing minimally invasive surgery * patients with a history of opioid use in the last 30 days * redo cases * patients with left ventricular ejection fraction less than 30% * patients with severe hepatic or renal insufficiency * patients with chronic pain before surgery (migraine, fibromyalgia)

Keywords: postoperative pain parasternal blocks chronic pain acute pain cabg
energy value of macronutrients from pistachio nuts and mechanisms of nutrient action

Conditions: Energy; Cardiovascular Disease; Cancer

Summary: the objective of this study is to measure the energy value of pistachios in the human diet and study molecular mechanisms that may help explain the beneficial health effects of pistachios.

previous studies have suggested that nut consumption imparts a variety of health benefits, including reduction of cardiovascular disease and improved satiety. however, studies of pistachios are extremely limited. the aim of this study is to determine the energy value of pistachios in the human diet and to probe mechanisms by which pistachios impart health benefits. the metabolizable energy value of pistachio nuts will be calculated based on the chemical composition and energy content of the consumed diet and excreta. this will provide a better estimate of the energy value of pistachios than simply calculating energy value based on atwater factors. in addition to determining the energy value of pistachios, we will evaluate the effects of pistachio-rich diets on plasma phytonutrient levels and on gene expression changes to determine what protective mechanisms are activated by pistachio consumption.

Eligibility criteria:
inclusion criteria: * age 25 to 65 years at beginning of study * bmi between 20 and 38 kg/m2 * fasting glucose \< 126 mg/dl * blood pressure \< 160/100 (controlled with certain medications) * fasting total blood cholesterol \< 280 mg/dl * fasting triglycerides \< 300 mg/dl exclusion criteria: * presence of kidney disease, liver disease, gout, hyperthyroidism, untreated or unstable hypothyroidism, certain cancers, gastrointestinal disease, pancreatic disease, other metabolic diseases, or malabsorption syndromes * type 2 diabetes requiring the use of oral antidiabetic agents or insulin * history of bariatric or certain other surgeries related to weight control * smokers or other tobacco users (during 6 months prior to the start of the study) * antibiotic use during the intervention or for 3 weeks prior to any intervention period * history of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets) * volunteers who have lost 10% of body weight within the last 12 months or who plan to initiate a weight loss program during the next 10 months * known (self-reported) allergy or adverse reaction to pistachios or other nuts * unable or unwilling to give informed consent or communicate with study staff * self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in alcoholics anonymous is not an exclusion) * other medical, psychiatric, or behavioral factors that in the judgment of the principal investigator may interfere with study participation or the ability to follow the intervention protocol

Keywords: pistachio nuts energy value cardiovascular disease phytonutrient gene expression energy value of pistachio nuts
interobserver agreement of endoscopic ultrasonography and endoscopic sonoelastography in the evaluation of lymph nodes

Conditions: Lymph Nodes; Esophageal Cancer; Gastric Cancer; Pancreatic Cancer; Liver Cancer

Summary: endoscopic ultrasound (eus) is an important part of the pre-treatment evaluation of patients with upper gastrointestinal tract cancer (esophageal, gastric, pancreatic and liver cancer). when planning the optimal therapy in patients with upper gastrointestinal malignancies it is essential to know the exact lymph node stage. recently endoscopic sonoelastography(es) has been added to conventional eus examination and may provide complementary information to distinguish benign for malignant lymph nodes. the n-stage relates to the treatment choice and the prognosis, and it is therefore of particular interest to know the interobserver agreement in operator dependent techniques. this study evaluate the interobserver agreement of eus and es evaluation og lymph nodes.


Eligibility criteria:
inclusion criteria: * the presence of a lymph node more than 10mm in diameter (short axis) detected during the eus examination exclusion criteria: * inadequate es images were obtained by one of the observers

Keywords: endoscopy endoscopic ultrasound endoscopic sonoelastography cancer interobserver agreement
the effect of schroth method on pain, body awareness and quality of life in adolescent individuals with idiopathic scoliosis

Conditions: Scoliosis

Summary: this study was aimed to compare the effect of schroth therapy method, which is a 3-dimensional scoliosis exercise method, and traditional exercises on pain, body awareness and quality of life in young individuals with idiopathic scoliosis.

38 individuals aged between 10-18 with the diagnosis of idiopathic scoliosis will be participated in the study. individuals (study group) underwent 1 hour exercise program 3 times a week for 6 weeks, and the individuals (control group) undervent a traditional exercise program once a week under supervision of physiotherapist for 6 weeks. during the rest of the week, same exercise program was given as a home program for at least half an hour a day and individuals will followed up. individuals' subjective pain intensity will be assessed with visual analogue scale (vas), pressure pain threshold by algometer, body awareness by turkish version of body awareness questionnaire and quality of life by turkish version of scoliosis research society (srs)-22 scale. measurements will be performed before and after the 6-week exercise program.

Eligibility criteria:
inclusion criteria: * having been diagnosed with idiopathic scoliosis by a specialist physician, * between the ages of 10-18, * primary curvature between 20-40 degrees according to the cobb method, * having c or s type of scoliosis, * having back / low-back pain due to scoliosis, * those who have not received any previous exercise therapy for scoliosis, * volunteering to participate in the study, * having the cognitive capacity to cooperate with the directions of the physiotherapist, * has not suffered any injuries to the musculoskeletal system in the last 6 months, * no neurological, orthopedic or cardiopulmonary disorders other than scoliosis diagnosis, * young individuals who have not undergone any surgery related to the diagnosis of scoliosis exclusion criteria: * previous spinal surgery, * any disease other than idiopathic scoliosis, * individuals who cannot adapt to the directions of the physiotherapist and cannot fulfill the requirements of the exercise program

Keywords: schroth idiopathic scoliosis pain quality of life body awareness
evaluation of fingertip precision pinch force in fibromyalgia patients

Conditions: Fibromyalgia; Force Measurement; Isokinetic; Muscle Strength

Summary: this study aims to evaluate the force used by fibromyalgia patients during a task compared to healthy volunteers and to evaluate its relationship with fatigue seen in these patients.

fatigue is a common symptom in fibromyalgia patients and it is known that these patients have decreased muscle strength compared to healthy volunteers. the aim of this study was to evaluate whether the minimum force to be applied during carrying is different in fibromyalgia patients compared to healthy volunteers.

Eligibility criteria:
inclusion criteria: -female patients diagnosed with fibromyalgia between the ages of 18-70 exclusion criteria: * those whose treatment has been changed in the last month * those with shoulder, elbow, wrist and hand diseases that may cause pain in the dominant upper extremity * those with carpal or cubital tunnel syndrome * those with a history of orthopedic surgery in the dominant extremity * those with uncontrolled metabolic disease * those with b12 deficiency

Keywords: fibromiyalgia muscle strength fatigue
a unique regimen for treatment of helicobacter pylori infection

Conditions: Helicobacter Infections

Summary: the triple treatment including proton pump inhibitor (ppi) -clarithromycin and amoxicillin or metronidazole was proposed 30 years ago at the first maastricht conference to treat helicobacter pylori (h. pylori) infection and since that time, it has become the universal and standard treatment for helicobacter pylori. however, the efficacy of this triple regimen has been seriously challenged, and they are gradually becoming ineffective

growing rates of treatment failure are observed worldwide and the eradication rate of triple therapy has declined over the past few decades. helicobacter pylori infection has become increasingly resistant to traditional first line treatment regimens because of emerging antibiotic resistance coupled with poor patient compliance with completing the treatment course that decrease h. pylori eradication rates .so there is a considerable interest in evaluating new antibiotic combinations and regimens .

Eligibility criteria:
inclusion criteria: * patients aged older than 21 years presenting by dyspepsia infected by h. pylori (as proved by positive stool antigen test) agreed to participate in the study and signed the consent exclusion criteria: * patients who have received treatment with proton pump inhibitors within 2 weeks, nsaid or antibiotics within 4 weeks before study entry patients who had received h pylori treatment before. patients presenting by upper gastrointestinal bleeding pregnant females patients who have significant gastrointestinal, renal, hepatic, cardiovascular, metabolic, hematological disease.
efficacy of allergen immunotherapy for allergic rhinitis in thais

Conditions: Rhinitis, Allergic, Perennial

Summary: the purpose of this study is to study the efficacy of allergen injection immunotherapy for allergic rhinitis by * symptoms score * medication score * quality of life * immunologic test from blood

compare the efficacy of allergen injection immunotherapy between the treatment group and the placebo group after injection for * 2 months * 6 months * 12 months

Eligibility criteria:
inclusion criteria: * patients with the symptoms of allergic rhinitis who sensitized to mite (dermatophagoides pteronyssinus) * positive skin prick test to d.p. at 4+ degree exclusion criteria: * steroid dependent asthma * force expiratory volume (fev1) less than 70% of predicted value * previous injection immunotherapy within 2 years * pregnancy * medical conditions such as ischemic heart disease, autoimmune disease, cancer, previous history of anaphylaxis

Keywords: allergic rhinitis allergen injection immunotherapy efficacy
safety and pharmacokinetics study of human monoclonal antibody (avp-21d9)

Conditions: Anthrax

Summary: primary: • to compare the safety profile of a single intravenous administration of avp-21d9 as compared with placebo secondary: * to evaluate the pharmacokinetics (pk) of a single intravenous administration of avp-21d9 * to evaluate the immunogenicity of avp-21d9

this is a sequential, dose-escalating healthy volunteer study of the safety and pharmacokinetics of intravenously-infused avp-21d9.

Eligibility criteria:
key inclusion criteria: * healthy volunteers, between 18 and 45 years of age * normal laboratory (blood test) results key exclusion criteria: * prior immunization with anthrax vaccine
preventing knee injuries in adolescent female football players

Conditions: Knee Injury

Summary: football-related knee injuries are common and especially the anterior cruciate ligament (acl) injury constitute a serious problem in football regardless of the playing level. the purpose of this study is to conduct a randomized controlled trial evaluating the effect of a training program designed to prevent acute knee injury in female adolescent football players. the investigators' hypotheses are: 1. a preventive training program reduces the incidence of acl injury, and 2. a high match frequency and match play at senior level increase the risk of acl injury.


Eligibility criteria:
inclusion criteria: * teams with female football players aged 13-17 years exclusion criteria: * teams that did not reply to the invitation or declined participation * teams having less than two scheduled training sessions per week * teams already using the preventive program

Keywords: incidence of acl injury risk factors for acl injury prevention of acl injury or any acute knee injury
development of maternal voice recognition in preterm neonates

Conditions: Infant, Premature

Summary: many cognitive functions in humans are based on asymmetrical brain networks. for example, in most adults, the language is essentially processed by the left hemisphere, while other auditory functions, such as voice recognition, tend to be processed by the right hemisphere. many studies, especially those conducted by ghislaine dehaene's team, have demonstrated the presence of anatomical and functional asymmetries by the first months of life. what are the causes of these asymmetries? how do they develop? are they necessary for functioning or effective learning? this study, conducted in collaboration with the compiègne applied mathematics team (abdelatif el badia) and the inserm team (ghislaine dehaene), is designed to determine the stage of development at which hemispheric dominance for voice recognition is first observed and to identify the brain structure involved in preterm neonates whose sound environment is usually very different from that of the foetus. the impact of this environment on the infant's brain development and early learning will be evaluated.


Eligibility criteria:
inclusion criteria: * the distribution of children in the different groups of infants included in the study will be validated at the time of the acquisitions. * normal group of children: a child meets the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological (etf, scanner, mri). * group of children meet the age criteria and with cerebral neurological pathology detectable after clinical, neurophysiological and radiological (etf, scanner, mri). exclusion criteria: about history: * all children with severe congenital malformation regarding the study period; * any refusal of a parent * children with severe impairment of the general condition and vital functions * children with dermatitis of the face or scalp * children treated with ventilation high frequency (hfo) * presence of intravenous access on the scalp (preventing the realization of the etf, eeg and nirs

Keywords: voice recognition
ilium mobilization in patellofemoral pain syndrome treatment

Conditions: Patellofemoral Pain Syndrome

Summary: aim of the study is to investigate the effect of adding posterior ilium mobilization on knee pain, knee function, anterior pelvic tilt, dynamic knee valgus, muscle strength of extensors, abductors and external rotators of hip and knee extensors in patients with patellofemoral pain syndrome.


Eligibility criteria:
inclusion criteria: 1. age of the subjects between 18-35 years. 2. bmi will be ≤ 29.5 3. anterior or retro patellar knee pain for at least 6 weeks duration. 4. foot posture index score from +6 to +12. 5. anterior pelvic tilt angle more than 8 degree. 6. pain elicited at least by two of the following four tests; (i) isometric muscle contraction with slight bent knee,(ii) palpation of the patellofemoral joint line, (iii) patellar compression against the femoral bone (iv) active resisted knee extension. 7. pain intensity more than 3 at anps and provoked by at least two of the following activities: running, walking, hopping, squatting, stair negotiation, kneeling, or prolonged sitting. exclusion criteria: 1. meniscal or other intraarticular pathologic conditions; cruciate or collateral ligament involvement. 2. a history of traumatic patellar subluxation or dislocation. 3. previous surgery in the knee, ankle and hip joints. 4. knee, ankle and hip joints osteoarthritis. 5. taking non-steroidal anti-inflammatory drugs or corticosteroids within 24 h before the test. 6. history of brain injury or vestibular disorder within the last 6 months. 7. pregnant female.

Keywords: patellofemoral pain syndrome strength stretch mobilization ilium innominate
comparison study of two iron compounds for treatment of anemia in hemodialysis patients

Conditions: Anemia of Chronic Kidney Disease

Summary: patients with end-stage kidney disease on maintenance hemodialysis frequently require iron supplementation to compensate for ongoing iron losses, and to maintain hemoglobin levels with or without additional use of erythropoiesis-stimulating agents (esa). the investigators aim to compare two different intravenous iron preparations, ferric carboxymaltose and iron sucrose in 140 hemodialysis patients. the investigators primary objective is to assess whether both agents are equally effective to maintain a target haemoglobin within 10-12 mg/dl. the investigators will also measure ferritin, transferrin, transferrin saturation, and how much esa therapy is administered. patients will be randomly assigned to either treatment group and followed in parallel over an active study period of 40 weeks.


Eligibility criteria:
inclusion criteria: * signed informed consent * male and female patients aged ≥ 18 * patients with anemia and end stage kidney disease on dialysis * hemoglobin ≥ 8,5g/dl * ferritin \< 1000mg/dl * tsat \< 50% * crp \< 5mg/dl exclusion criteria: * hemoglobin \< 8,5g/dl * pregnancy or nursing * known allergic reaction to i.v. iron supplementation or to ingredients of investigational medicinal product (imp) * chronic infections (hiv, hep b, hep c) * acute infections (crp\>5mg/dl; antibiotic therapy except for prophylactic use) * malignant tumor disease * oral iron supplementation at study inclusion * participation in a different study at the same time * active bleeding issues * surgical intervention within the last 4 weeks before study inclusion * mental diseases * bronchial asthma * atopic allergy * eczema * receipt of red blood cell (rbc) concentrate within the last 4 weeks before study inclusion