Kornimate/medical-research-clean huggingface dataset:
effects of high ventilation breathwork with retention (hvbr) on health

Conditions: Stress; Anxiety; Depressive Symptoms; Mental Wellbeing; Positive Affect; Negative Affect; Sleep-Related Impairment

Summary: the investigators are conducting a randomised-controlled trial comparing high ventilation breathwork with retention (hvbr) to a breathwork placebo (paced breathing at 15breaths/min with brief retentions). the metric of 15b/min aligns with guidance from the british journal of nursing, royal college of physicians and johns hopkins medicine which state that the average, healthy rate should range from: 12-20, 12-18 and 12-16b/min, respectively. the main questions the study attempts to address are: does hvbr lead to improved state and trait mental health and wellbeing in a general population adult sample? the study will be conducted entirely online through the research platform prolific, so participant data will be anonymous. the investigators will collect self-reports of mental health and wellbeing before and after the three-week breathwork period, in addition to a follow-up three weeks later. pre-post intervention and follow-up questionnaires will be completed online via the survey platform qualtrics which will be linked to prolific. data on self-reported adherence to, and credibility/expectancy of, the breathwork will also be collected, along with participants' experiences to gauge the safety and tolerability of the breathwork protocol.


Eligibility criteria:
inclusion criteria (self-assessed): * fluent in english and living in the uk * have access to headphones * comfortable with faster breathing and holding breath * willing to only practice breathwork in safe environment, lying down in soft area (i.e., bed, sofa, carpet/mat), and always away from water \& hard ground * willing to only practice the breathwork away from large meals (i.e., before or 1hour after) and bedtime (i.e., at least 1 hour before if practicing in evening) exclusion criteria (self-assessed): * hypotension or hypertension (low or high blood pressure) * history of respiratory or cardiovascular/heart problems or disease * history of fainting or syncope * epilepsy or seizures * history of panic disorder or panic attacks * cerebral aneurysm * have had problems with prior breathwork sessions (i.e., fainting) * pregnancy, think one might be pregnant, trying to get pregnant, or are breastfeeding * any problems which affect one's ability to pace their breathing (i.e., active/chronic respiratory infection including blocked nose/cough/cold/fever, etc.), breathlessness, abnormally slow breathing (bradypnea), or abnormally fast breathing (tachypnoea) * any other physical/mental health conditions or current life events which impair or affect one's ability to engage in activities involving breath control * are taking any regular medication other than the contraceptive pill, including medications to reduce blood pressure (i.e., ramipril or other ace-inhibitors), beta blockers (i.e., propranolol), antidepressants, anxiolytics or any other psychotropic medications
mobilising lower limb fluid for hemodynamic stability in haemodialysis

Conditions: Kidney Failure

Summary: cardiovascular disease is the leading cause of death of dialysis patients and poor fluid management is associated with the increased risk. one of the principal limitations in avoiding chronic fluid overload in this patient group is the refilling rate the rate at which fluid is transferred from tissues into the vascular system. if this rate cannot match the prescribed rate of fluid removal during dialysis the patient will end up with chronic fluid overload. two proposed methods of increasing the rate of refilling are intermittent pneumatic compression (ipc) devices, which increase the pressure of the fluid in tissue, and neuromuscular electrical stimulation (nmes) which activates the muscle pump and lymphatic drainage. this investigation will trial the use of these two methods in patients suspected of having inadequate refilling rates. outcome measures will be based on fluid status, presence of oedema and quality of life.


Eligibility criteria:
inclusion criteria: * presence of lower limb oedema as defined by pitting * average post dialysis fluid overload in relation to target weight greater than 0.5 litres * greater than one dialysis session that included an intradialytic hypotensive episode in the previous month, defined by saline influsion or nursing intervention exclusion criteria: * less than 18 years of age * less than 3 months dialysis vintage * presence of metal implants, amputations or the inability to be weighed
iron deficiency anemia among chinese pregnant women: a multi-center prospective cohort study

Conditions: Iron Deficiency Anemia of Pregnancy

Summary: iron deficiency anemia during pregnancy, which may lead to adverse pregnancy outcomes, was a serious health problem in china. various iron supplements used in different regions of china, however, the effects have not been well investigated. the objective of this study is to investigate the diagnosis, treatment and prognosis of iron deficiency and iron deficiency anemia in chinese pregnant women.

this is a nationwide multicenter prospective cohort study conducted in seven hospitals in china to investigate the diagnosis, treatment and prognosis of iron deficiency and iron deficiency anemia in chinese pregnant women. this study will enroll about 6000-7000 pregnant women, who established a health record in the seven hospitals. demographic characteristics, laboratory tests, behavior habits during pregnancy, mental status, and pregnancy outcomes will been collected. all information will collect by a pregnant women self-reported questionnaire and the electronic medical record system in hospitals at three timing points: 6-15 gestational weeks, 30-34 gestational weeks and one week after delivery.

Eligibility criteria:
inclusion criteria: * pregnant women who registered an antenatal care file at the survey hospital ; * signed informed consent. exclusion criteria: * participated in any drug or nutritional clinical trial from 3 months before pregnancy to recruitment.

Keywords: iron deficiency anemia iron supplements chinese pregnant women adverse maternal outcomes adverse neonatal outcome
study of sulphoraphane in chronic kidney disease

Conditions: Chronic Kidney Disease stage3; Chronic Kidney Disease stage4

Summary: the purpose of this study is to test the safety of the compound sulforaphane that boosts the activity of antioxidant genes in the body to combat oxidative stress. oxidative stress has been shown experimentally to play a role in kidney disease. this drug has been tested in patients with breast cancer who have normal kidney function, but has never been tested in patients with kidney disease. in this study, the investigators will establish a safe dose for patients with chronic kidney disease based on blood levels achieved in patients with normal kidney function.

we hypothesize that daily intake of sulforaphane (avmacol extra strength (es)) can decrease kidney disease progression rate and decrease markers of oxidative stress and inflammation in chronic kidney disease (ckd) patients. to test our hypothesis, we will first perform a randomized, phase 1 clinical trial in a single center funded by an r01 niddk award. this is an interventional pharmacokinetic trial, with subjects randomized to different doses of avmacol es.

Eligibility criteria:
inclusion criteria: * egfr ≥ 20 and \<60 ml/min/m2/year, and a decline in egfr of ≥ 3 ml/min/m2/year in the previous 12 months * blood pressure \<140/90 mm hg prior to initiation of sulphoraphane * stable anti-hypertensive regimen for at least one month prior to initiation of sulphoraphane or successful run-in period * able to provide consent * able to swallow capsules exclusion criteria: * significant co-morbid conditions with life expectancy of \<1 year * uncontrolled hypertension * serum potassium of \>5.5 meq/l at screening * new york heart association class 3 or 4 heart failure symptoms, known ef ≤30% or hospital admission for heart failure within the past 3 months * factors judged to limit adherence to interventions * current participation in another study * pregnancy or planning to become pregnant or currently breastfeeding * history of dementia * on anticoagulants or immunosuppression * under treatment for cancer
impact of sprinkles on infectious morbidity when moderate to severe pediatric malnutrition is highly prevalent

Conditions: Malnutrition; Iron Deficiency

Summary: the purpose of this study is to determine the safety profile of oral iron supplementation (ois) with sprinkles in a pediatric population with high prevalence of iron deficiency (id) and moderate or severe malnutrition (msm); the efficacy profile will also be investigated.

iron deficiency (id) affects many children in developing countries. anemia and impaired brain development are its most significant consequences. these may be prevented by giving oral iron supplements (ois), such as sprinkles. id treatment was controversial because high dose parenteral iron therapy is strongly associated with severe infections when given to severely malnourished children. many studies have since demonstrated the safety of low dose ois. who guidelines reflect this finding: population-wide iron supplementation campaign (pwisc), without prior screening, is recommended when id prevalence is ≥ 40%. however, a gap in the safety evidence has been identified: children with moderate or severe malnutrition (msm) are strikingly absent from the studies performed to date to investigate the link between ois and infectious morbidities. in this context, pwisc may have unrecognized deleterious effects when the prevalence of msm is high, since safety is assumed, but incorrectly extrapolated from available evidence. we wish to emphasize an additional concern with regards to safety studies published thus far: all were designed as superiority trials. in this context, it is statistically incorrect to conclude that failure to show a significant difference between iron and placebo means that their respective side-effect profiles are similar.

Eligibility criteria:
inclusion criteria: * children aged 12 - 24 months * moderate to severe malnutrition (msm), defined as weight-for-age z-score ≤ -2 based on the national center for health statistics (nchs) standards exclusion criteria: * severe anemia (hemoglobin ≤70g/l) * near normal hemoglobin concentration (\>100g/l) * weight-for-height \<-3 z-score (severe wasting) * kwashiorkor (defined as evidence of edema) * congenital abnormality or disease * treatment with iron supplements in the past 3 months * inclusion in a nutrition program in the past * chronic illness other than malnutrition.

Keywords: pediatrics malnutrition iron deficiency sprinkles oral iron supplementation
a study comparing the efficacy and safety of nivolumab in combination with bacillus calmette-guerin (bcg) versus bcg alone in participants with high-risk non-muscle invasive bladder cancer (hr nmibc)

Conditions: Urinary Bladder Neoplasms

Summary: a study comparing nivolumab and bacterial drugs given to help the body's immune system in the bladder versus bacterial drugs alone in high risk bladder cancer participants.


Eligibility criteria:
inclusion criteria: * persistent or recurrent disease ≤ 24 months of last bcg dose, but not classified as bcg unresponsive * histologically confirmed persistent or recurrent high-risk non-muscle-invasive urothelial carcinoma (uc) * treated with at least 1 adequate course of induction bcg therapy (at least 5 out of 6 doses) * eastern cooperative oncology group (ecog) performance status (ps) 0-2 exclusion criteria: * previous or concurrent muscle invasive, locally advanced, or disseminated/metastatic uc * uc in the upper genitourinary tract (kidneys, renal collecting systems, ureters) within 24 months of enrollment * uc and/or cis in the prostatic urethra within 12 months of enrollment other protocol-defined inclusion/exclusion criteria apply
action observation training in patients with chronic low back pain

Conditions: AOT; Low Back Pain

Summary: the study is a single-blind controlled randomized clinical trial.

patients will be recruited and then randomly assigned by an external collaborator to the experimental group or to the control group. to the patients that belong to the experimental group will be asked to watch a video showing a person carrying out some exercises (12 exercises: 3 of stretching, 3 of core stability, 3 of mobilization and 3 of functional) and then they will have to practice them.on the other hand, to the patients that belong to the control group will be given a brochure with the same exercises the patients of the experimental group received through the video. both groups will have to watch the video or read the brochure and repeat the exercises 5 times per week for 3 weeks. patients will be evaluated before the treatment (t0), three weeks after the beginning (t1) and 4 months upon the end of it (t2). the evaluation will consist in the administration of the oswestry disability index, of the tampa scale of kinesiophobia, of the numerical rating scale and of the medical outcomes study short form 36. a physiotherapist will instruct the patients about the exercises while a second one blinded about the belonging group of patients, will administer the evaluation scales.

Eligibility criteria:
inclusion criteria: * patients with chronic aspecific lbp (documented story of more than 12 week-long symptomatology) * good understanding of italian language * aged over 65 exclusion criteria: * severe sight or hearing impairement * cognitive deficit (assessed by a mini mental state examination score ≤21 \[14\]). * specific lbp (previous spine surgery, deformation, infection, fracture, malignant tumor, general disorders or neuromuscular pathologies) * patients who previously experimented aot
smartphone addiction and physical activity

Conditions: Sports Physical Therapy

Summary: this study aimed to determine the effect of smartphone addiction on physical activity level in healthy individuals. a total of 300 (134 female) healthy university students were included in this study. the mean age of the subjects was 21.36 ± 2.33 year.

this study aimed to determine the effect of smartphone addiction on physical activity level in healthy individuals. a total of 300 (134 female) healthy university students were included in this study. the mean age of the subjects was 21.36 ± 2.33 year. the universe of the study consisted of volunteer students (coaching education, physical education and sports teaching, sports management, recreation departments) at the faculty of sport sciences. participants' demographic information was obtained and their physical activity levels were questioned with international physical activity questionnaires (ipaq) and smartphone addictions with the smartphone addiction scale- short verison (sas-sv).

Eligibility criteria:
inclusion criteria: * to be 18-35 old years exclusion criteria: * not to be sports science students

Keywords: addiction healthy individuals physical activity smartphone sport science
efficacy, tolerability and handling of daivobet® gel in patients with psoriasis vulgaris

Conditions: Psoriasis Vulgaris

Summary: the purpose of this observational study is to evaluate the efficacy, tolerability, quality of life and handling of daivobet® gel by both physician and patient in daily practise.


Eligibility criteria:
inclusion criteria: * patients with light to moderate psoriasis vulgaris of trunk and extremities and treatment with daivobet® gel was planned anyway exclusion criteria: * previous therapy with daivobet® gel * systemic therapy of psoriasis vulgaris * contraindications of daivobet® gel in the german package insert
the effect of relaxing breathing exercise applied to patients before bone marrow biopsy on vital signs, pain and anxiety levels

Conditions: Bone Marrow Cancer

Summary: there is no study in the literature that determined the effect of relaxing breathing exercise applied to patients before the bmb procedure on vital signs, pain and anxiety levels. the aim of this study is to determine the effect of relaxing breathing exercise applied to patients before bone marrow biopsy on vital signs, pain and anxiety levels. hypotheses h1. relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure reduces the anxiety level of the patients compared to the control group. h2. relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure reduces the pain level of the patients compared to the control group. h3. relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure is effective on the respiratory rate of the patients compared to the control group. h4. relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure is effective on the pulse rate of the patients compared to the control group. h5. relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure is effective on the blood pressure of the patients compared to the control group.


Eligibility criteria:
* being between the ages of 18-65 * the fact that a bone marrow biopsy will be performed for the first time * absence of sedative, anxiolytic drug use * absence of a situation that would hinder communication.

Keywords: bone marrow biopsy pain breathing exercise anxiety
oral postbiotics in patients with macular atrophy

Conditions: Geographic Atrophy; Age-Related Macular Degeneration

Summary: a pilot study to evaluate the safety and efficacy of oral therapy with postbiotics in patients with geographic atrophy secondary to age-related macular degeneration, myopia, or angioid streaks.

a pilot study to evaluate the safety and efficacy of oral therapy with postbiotics in patients with geographic atrophy (ga) secondary to age-related macular degeneration, myopia or angioid streaks. the study's main objective is to evaluate if oral postbiotic therapy will induce epigenetic factors that would impact the progression of the ga, and it will compare the rate of growth of ga from the baseline to 12 months, to the rate shown during the 12 months before baseline.

Eligibility criteria:
inclusion criteria: * patients with ga secondary to amd, myopia or angioid streaks * with 12 months of previous follow-up, * and a known progression of \>0,20mm/year as per sqrt exclusion criteria: - history of choroidal neovascularization in the study eye

Keywords: postbiotics microbiota microbiome geographic atrophy atrophic amd amd age-related macular degeneration
bevacizumab and peripheral retinal changes on wide field angiography in diabetic macular edema

Conditions: Non-proliferative Diabetic Retinopathy; Proliferative Diabetic Retinopathy; Diabetic Macular Edema

Summary: ultra-wide field fluorescein angiography can detect the response of anti vgef therapy such as avastin on retinal ischemia in the setting of diabetic macular edema.

the major causes of vision loss in diabetic retinopathy are diabetic macular edema (dme) characterized by thickening of the macula due to abnormal leakage of the retinal vasculature. ischaemic changes and microvascular pathologies have long been hypothesized to play a role in the development of dme. in diabetic retinopathy, ischaemia stimulates the production of vascular endothelial growth factor (vegf), which can lead to the breakdown of blood-retinal barriers, and may cause dme through an increase in retinal vessel permeability. dme is best evaluated by optical coherence tomography (oct) while retinal ischemia is determined by fluorescein angiography. with the avaiability of ultra wide field fluorescein angiography, the investigators can now accurately measure the degree of ischemia in peripheral retina. thus, this study will provide us data on the degree of retinal ischemia in nonproliferative diabetic retinopathy (npdr) and proliferative diabetic retinopathy (pdr) cases as well as the measurable change that occurs in retinal ischemia after intra vitreal injection of bevacizumab.

Eligibility criteria:
inclusion criteria: 1. diabetic patients at age \>18year with dme 2. scheduled for avastin therapy 3. adequate media to obtain oct and uwfa exclusion criteria: 1. macular pathology of any etiology 2. preexisting systemic disease causing retinal ischemia 3. previous laser or anti-vegf treatment in past 3 months 4. previous retina surgery in past 2 months 5. allergy to fluorescein dye 6. psychiatric disorder, alzheimer disease and dementia or any other disorder precluding follow-up or continuation of the study.

Keywords: peripheral retinal ischemia ultra wide field fluorescein angiography bevacizumab
stability of anterior open bite treatment using extrusion arches

Conditions: Anterior Open Bite Malocclusion

Summary: this study investigated treatment effects and stability of anterior open bite cases using extrusion arches


Eligibility criteria:
inclusion criteria: * adult patients above 18 years anterior open bite 2-6 mm full permanent dentition incisors requiring extrusion exclusion criteria: * increased incisal show at rest * gum show at smiling cleft patients patient with tempro-mandibular joint problems fma angle above 45

Keywords: extrusion arches anterior open bite stability extrusion intrusion
clinical performance of chairside cad/cam restorations

Conditions: Dental Cements; Caries,Dental

Summary: this investigation will be a longitudinal clinical trial to study the long-term clinical performance of a resin cement for chairside cad/cam restorations. lithium disilicate chairside cad/cam onlays will be adhesively bonded using a selective enamel etch technique with an adhesive. full contour zirconia crowns will be cemented using a self-adhesive resin cement.

a wide variety of restorative materials are available for dental restorations. the most popular current materials include glass ceramics and full contour zirconia. glass ceramic materials are generally preferred for their high translucency mimicking enamel-like esthetics of natural teeth and zirconia is preferred for high strength applications. both of these materials are available for clinical treatment using chairside cad/cam technology. the introduction of an induction sintering oven (speedfire oven/dentsply sirona) opened the opportunity for chairside full contour zirconia crowns by decreasing sintering times for zirconia to under 30 minutes. 3m chairside zirconia (3m) was marketed in 2019 and offers improved esthetics and high strength for monolithic zirconia restorations with an efficient processing time. this investigation will be a longitudinal clinical trial to study the long-term clinical performance of cad/cam restorations. lithium disilicate chairside cad/cam onlays (ips emaxcad/ivoclar) will be adhesively bonded using a selective enamel etch technique with a universal adhesive (3m) and a resin cement (3m). full contour zirconia crowns (3m chairside zirconia/3m) will be cemented using a self-adhesive technique.

Eligibility criteria:
inclusion criteria: * subject in need of crown and/or onlay restoration * subject age 18 or above * subject with healthy / treated periodontal status (max. degree of movement 1) * subject agrees to participate in the study and signed informed consent and hipaa form exclusion criteria: * devital or sensitive teeth * teeth diagnosed with symptoms of incomplete tooth fracture * teeth with prior endodontic treatment of any kind * teeth with a history of direct or indirect pulp capping procedures * subjects with uncontrolled bruxism or parafunctional habits * subject has known allergies to any product used in this study * subject will not be available for the study duration * subjects with significant untreated dental disease to include periodontitis and rampant caries * pregnant or lactating women