Kornimate/medical-research-clean huggingface dataset:
testing the competency-based theory of change for suicide risk among young male internet users with societal masculinity

Conditions: Self-Harm, Deliberate; Suicidal Ideation; Masculinity

Summary: to propose a competency-based theory of change for reducing suicide risks among male internet users with salient traits of societal masculinity; to test whether the theory of change using the competency-based model has additional effects on reducing self-harm and/or suicidal ideation in addition to the online social work treatment-as-usual model; to provide online social work service providers with evidence-based measures for reducing the risks of self-harm and/or suicide among young male internet users.

this is a randomized waitlist-controlled trial of 60 participants examining the effects of a proposed competency-based model on self-harm relative to those of osw alone. in the online survey (t0), subjects with self-harm or suicidal ideation will be invited to give informed consent, and then be randomly assigned to one of two groups: 1) osw (control), or 2) osw + six weekly sessions of competency-based physical training (intervention). they will be assessed at three measurement time points (t1 = one-month; t2 = three-month; and t3 = five-month from t0 at post-intervention). the intervention group is hypothesized to display a greater reduction in the primary outcomes of self-harm and suicidal ideation than the osw group. chi-square tests giving p \<=0.05 will indicate a goodness of fit of the linear mixed model, which address random effects in the data and handles intention-to-treat (itt).

Eligibility criteria:
inclusion criteria: * individuals who meet the cut-off of 1.0 on the chinese adult suicidal ideation questionnaire (asiq4); self-injury incidents in the past 12 months exclusion criteria: * individuals with severe physical disabilities
a phase iii trial of safety and efficacy of premedication with dexmedetomidine and midazolam in pediatric patients

Conditions: Anxiety State; Perioperative/Postoperative Complications

Summary: this research study to evaluate the relative efficacy of dexmedetomidine, midazolam, and compare them to the current kfsh\&rc standard of care. compare the safety and the frequency of adverse effects of treatment arms.


Eligibility criteria:
inclusion criteria: * all pediatric outpatients coming for mri investigations requiring general anesthesia at king faisal specialist hospital \& research center (kfsh\&rc) age 1-12 years exclusion criteria: * weight ≥ 40 kilograms * allergies to the study drug * refused to take the study drug * severe learning disability * patient on digoxin medication * patient on beta-blocker medication * cardiac disease with abnormal conduction system * nasal anatomical abnormality
effect of mental stress on platelet function in healthy subject

Conditions: Healthy

Summary: psychological stress is an independent cardiovascular risk factor. activation of platelets plays an important role in atherosclerosis development and it could one of the mechanisms linking psychological stress and cardiovascular diseases


Eligibility criteria:
inclusion criteria: * healthy subjects * no smokers * written informed consent exclusion criteria: * smoking * alcohol- or drug abuse * pregnancy * use of benzodiazepins, aspirin or nsaids in the last week before inclusion * participation to another study within the last month

Keywords: mental stress cardiovascular risk factor platelet adhesion
efficacy and safety of venofer (iron sucrose injection usp) in patients receiving peritoneal dialysis

Conditions: Anemia

Summary: this is a open-label, prospective study comparing intravenous (iv) iron supplementation to standard care in anemic patents undergoing peritoneal dialysis.

this is an open-label, prospective study comparing iv iron supplementation to standard care in anemic patients undergoing peritoneal dialysis. after successfully completing a 6 month enrollment period, qualifying patients were randomized to receive 1000mg of iv iron over a four week period, or no iron supplementation. erythropoietin regimen was to remain stable. patients were followed to day 71 for safety and efficacy.

Eligibility criteria:
inclusion criteria: * hemoglobin \>= 9.5 and \<= 11.5 g/dl. * ferritin \<= 500 ng/ml. * serum transferrin saturation (tsat) \<= 25%. * stable erythropoietin (epo) regimen for 8 weeks. * no iron for last 4 weeks before randomization. exclusion criteria: * known sensitivity to iron sucrose. * suffering concomitant severe diseases of the liver \& cardiovascular system. * pregnancy / lactation. * inadequate dialysis. * current treatment for asthma. * significant blood loss. * probability of need for transfusion or transfusion within 1 week of enrollment. * anticipated major surgery. * hemochromatosis / hemosiderosis.

Keywords: iron peritoneal dialysis anemia
development and validation of a sputum biomarker mrna panel for the diagnostic work-up of asthma 1.

Conditions: Asthma Patients; Healthy Subjects

Summary: the main objectives of the study are 1. to study the different t cell subtypes (th1, th2, th17 and treg) in the lower airways of healthy subjects and clinically different asthma patients, based on a non-invasive procedure of sputum induction. patients will be different in function of age, in relation to the trigger (eg aspirin, without or with association with polyposis), without or with underlying atopic sensitization or different in the type of underlying inflammation (eosinophilic vs neutrophilic). this t cell pattern will become the basis of molecular phenotyping in the patients. 2. to study the usefulness of asthma molecular phenotyping (by following the balance between the inflammatory markers on the one hand and the regulatory markers on the other hand) in asthma guidance (longitudinally). the final goal of this project is then to develop a sputum non-invasive biomarker array that can be used to distinguish the different inflammatory asthma phenotypes and that can predict steroid resistance and/or sensitivity to other anti-inflammatory medication, using a non-invasive technique that can be used also at young age and repetitively.


Eligibility criteria:
inclusion criteria: * asthma diagnosis exclusion criteria: * viral/bacterial/fungal infection with fever (\<1 month ) * other airway diseases (cf, ciliar dyskinesia, bronchiectasis) * asthma exacerbation (\<3 months)
post-marketing surveillance of humira in korean pediatric crohn's disease (cd) patients under the "new-drug re-examination"

Conditions: Pediatric Crohn's Disease

Summary: this study is a non-interventional, observational study of humira® in the treatment of pediatric cd as per the new drug re-examination guideline in korea. this study will be conducted in institutions which provide a written agreement to abbvie korea, and where the use of humira® for pediatric cd is following their normal medical practice setting. pediatric patients who are prescribed humira® as per physician's medical judgment in accordance with the approved korean local label will be enrolled in the study. as this is a post marketing surveillance, abbvie is not involved in the product supply since the drug is being used according to the approved marketing label and is to be prescribed by the physician under usual and customary practice of physician prescription.


Eligibility criteria:
inclusion criteria: * pediatric patients with cd who are prescribed humira in accordance with the korean label for humira authorization (labeling) * patients who have given written authorization to use their personal health data for the purposes of this study. exclusion criteria: * any contraindications to humira as listed on the approved product market authorization (labeling) * patients who is participating on other clinical trials.

Keywords: korea humira pediatric crohn's disease
effectiveness of neuroscience-based pain education in patients with chronic neck pain

Conditions: Cervical Spine Disease

Summary: the effectiveness of neuroscience-based pain education, myofascial induction technique, and home exercise programs will be compared in patients with chronic neck pain.

the study aims to present the immediate and long-term effects of neuroscience-based pain education (npe) and myofascial induction therapy (mit). it will evaluate parameters such as pain, quality of life, pain catastrophizing, and neck disability after treatment completion and at the 6-month follow-up. the investigators aim to illuminate future studies concerning neuroscience-based pain education, which has gained prominence in recent years and continues to increase in importance annually. the participants will be randomly assigned to one of three groups: 1 group: neuroscience-based pain education combined with home exercise program participants in this group will receive neuroscience-based pain education (npe) treatment in addition to the home exercise program. training sessions will be organized as one-on-one conversation sessions focusing on the neurophysiology of pain, and participants will be reinforced through powerpoint presentations and visual aids such as pictures, templates, and metaphors. group: myofascial induction techniques combined with home exercise program in addition to the home exercise program, myofascial induction techniques (mit) group participants will have mit applied to the cervical and upper thoracic regions. group: home exercise program after undergoing general training, participants in this group will be taught an exercise program. the program will include neck muscle stretching, strengthening, and posture exercises.

Eligibility criteria:
inclusion criteria: 1. ages between 18-60 years old, 2. patients with non-specific neck pain for at least 3 months, 3. having pain severity of four or more according to the visual analogue scale (vas), 4. patients with pain catastrophizing scale score \> 30 5. patients with a central sensitization inventory score \> 30 6. not having received physiotherapy and manual therapy within the last 3 months, 7. those who have not received and will not receive medical treatment in the last 3 months. exclusion criteria: 1. having a history of neck and spine surgery, 2. patients with whiplash injury, fracture history, 3. having unstable neurological findings, 4. presence of a pathology such as hernia and root compression in the cervical region, 5. those who regularly use analgesic and anti-inflammatory drugs, 6. a communication problem may prevent the implementation of the evaluations or treatment program.

Keywords: pain neuroscience education myofascial induction technique myofascial treatment home exercises pain neck disability
comparison of trabeculectomy versus the ex-press miniature glaucoma device in the same patient: a prospective randomized study

Conditions: Glaucoma

Summary: the purpose of this study was to compare standard trabeculectomy to the ex-press mini glaucoma shunt implantation under a scleral flap in eyes with open-angle glaucoma.in this report, we describe the results of a prospective, randomized trial in which subjects with bilateral primary open-angle glaucoma underwent the two procedures in fellow eyes.design: prospective, randomized clinical trial. participants: 15 subjects with bilateral primary open-angle glaucoma methods: subjects underwent the two procedures in fellow eyes. safety and efficacy were evaluated for up to two years. main outcome measures: mean iop and surgical success rates. results: mean iop was similar in ex-press and trabeculectomy eyes at all time points except month 9, when ex-press eyes had lower mean iop (13.2 mmhg vs 16.5 mmhg, respectively; p=0.025). percent iop reduction was also similar at all time points except postoperative day 1, when trabeculectomy eyes were lower (75.5% vs 65.8%, respectively; p=0.003), likely due to a higher rate of early hypotony in trabeculectomy eyes versus ex-press eyes (47% vs 7%, respectively). complete (without medications) and qualified (with or without medications) successes were more common at all iop cut-off values in ex-press eyes than trabeculectomy eyes at last visit (p=0.015, p=0.015 respectively). postoperative complications were uncommon in both groups, but trabeculectomy eyes required more postoperative interventions than ex-press eyes.


Eligibility criteria:
inclusion criteria: * subjects were at least 18 years of age and * had medically uncontrolled primary open-angle glaucoma requiring incisional surgery for reduction of intraocular pressure in both eyes. * subjects with prior cataract or failed filtration surgery in either eye were eligible to participate if surgery occurred at least 3 months prior to enrollment. exclusion criteria: * any form of glaucoma other than primary open-angle glaucoma; * history of or active uveitis; or * any ocular abnormality that would prevent accurate assessment of intraocular pressure

Keywords: at least 18 years of age open-angle glaucoma
health and wellbeing of pregnant and post-partum women during the covid-19 pandemic

Conditions: COVID-19; Pregnancy Complications; Mental Health Wellness 1; Anxiety; Depression; Ptsd; Coronavirus

Summary: the purpose of this study is to assess the health and wellbeing of pregnant and recently pregnant women during the covid-19 pandemic using an online survey.

millions of women will give birth during the pandemic of coronavirus disease 2019 (covid-19) caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2). the consequences of covid-19 for pregnant women and their offspring are unknown. this lack of information leads to anxiety among pregnant women, women who are considering getting pregnant, and their families. it is therefore important to assess the wellbeing and mental health of women during the covid-19 pandemic. the international nature of the online survey will allow the evaluation of how living during the covid-19 pandemic affects pregnant and recently pregnant women at a global level, including the evaluation of potential cultural and geographic differences.

Eligibility criteria:
inclusion criteria: * pregnant women or women who have been pregnant within the last 6 months * able to give electronic informed consent exclusion criteria: * \<18 years of age
preventative study against urate-lowering drug-induced gout exacerbations (pre-surge 2)

Conditions: Gout

Summary: the purpose of this clinical research study was to determine the safety and effectiveness of an experimental drug called rilonacept in participants with gout who are beginning allopurinol treatment for gout. participants will participate in this study for approximately 22 weeks. rilonacept was being studied for use in preventing allopurinol-induced gout flares.


Eligibility criteria:
inclusion criteria: * male or female 18 to 80 years of age; * previously met the preliminary criteria of the american rheumatism association (ara) for the classification of the acute arthritis of primary gout; * at least 2 gout flares in the year prior to the screening visit; * serum uric acid greater than or equal to 7.5 mg/dl at the screening visit. exclusion criteria: * acute gout flare within 2 weeks of the screening visit or during screening; * persistent chronic or active infections; * history of an allergic reaction to allopurinol; * history or presence of cancer within 5 years of the screening visit; * previous exposure to rilonacept; * use of allopurinol, benzbromarone, febuxostat, probenecid or sulfinpyrazone within 3 months prior to the screening visit.

Keywords: intercritical gout metabolism, inborn errors allopurinol metabolic diseases genetic diseases, inborn musculoskeletal diseases joint diseases arthritis rheumatic diseases metabolic disorder purine-pyrimidine metabolism, inborn errors gout
postoperative pain management following laparoscopic cholecystectomy

Conditions: Postoperative Pain

Summary: postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. no. study has investigated vortioxetine as an adjuvant to standard care for postoperative pain management in patients undergoing lc

postoperative pain is a main challenge for delayed hospital discharge in laparoscopic cholecystectomy. . postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. vortioxetine (vo) is a multimodal serotonergic antidepressant with a unique mechanism of action that is effective in treating neuropathic pain. the purpose of this study is evaluating the efficacy and tolerability of preoperative oral administration of vortioxetine on postoperative pain control in patients undergoing lc

Eligibility criteria:
inclusion criteria: * patients who are scheduled to undergo elective lc. * adults (males and/or females) between the ages of 18-70 years old. exclusion criteria: * chronic pain other than cholelithiasis. * patients who received analgesics or sedatives 24 h before scheduled surgery. * severe hepatic (child pugh class b and c) and renal dysfunction (crcl \<30ml/min) * previous allergic response to vortioxetine. * pregnancy and lactation * patients with communication problems, cognitive dysfunction, or psychological disorders * daily corticosteroid use

Keywords: laparoscopic 5-ht3 and 5-ht7 receptors inhibition post-operative pain
a multidisciplinary approach to improve the health of older adults with blood cancers after stem cell transplantation

Conditions: Hematopoietic and Lymphoid Cell Neoplasm

Summary: this clinical trial studies the usefulness and process of a multidisciplinary intervention, where patients see multiple healthcare professionals, aimed at improving fitness and the ability to bounce back after transplant for older adults with blood cancers planned for stem cell transplantation. using a multidisciplinary team approach may increase patients' ability to withstand the transplant by optimizing health to better prepare patients for the expected complications after stem cell transplantation.

primary objective: i. evaluate the feasibility of delivering a geriatric assessment guided by a multi-disciplinary team (mdt) intervention before allogeneic hematopoietic cell transplantation (hct) in older patients. secondary objectives: i. establish successful dose intensity of resiliency bolstering. ii. describe hct utilization among enrolled patients. iii. create a standardized and exportable library of mdt-facilitated interventions. iv. estimate the benefit derived from the mdt approach compared to historic controls for day +100 outcomes of falls, delirium and functional decline. v. quantify early functionally independent survival (fis) to estimate hct-associated health span decline. exploratory objectives: i. characterize reasons patients do not undergo hct after mdt intervention. ii. associate early fis with 1-year non-relapse mortality (nrm) and overall survival (os). iii. integrate virtual assessment and interventions. iv. correlate image defined sarcopenia with objective function. v. biobank blood and stool for future studies of accelerated aging. outline: patients participate in the mdt-intervention including access to a hct physician, a geriatrician, physical or occupational therapist, dietician, and a social worker for three months before hct and up to 100 days after hct. after completion of study, patients are followed up for up to 1 year.

Eligibility criteria:
inclusion criteria: * documented informed consent of the participant * \>= 65 years at time of planned hct infusion * anticipated to be candidate for allogeneic transplant per treating physician at the time of enrollment * ability to read english, spanish or mandarin. other languages will be acceptable with principal investigator (pi) agreement if surveys are available and language does not preclude completing study procedures * any conditioning regimen and allogeneic donor permitted * hematologic malignancy or disease as indication for hct * willing and able to complete study requirements exclusion criteria: * prior allogeneic stem cell transplant * syngeneic donors for hct * any other condition that would, in the investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures
dynamic ct myocardial perfusion imaging

Conditions: Coronary Artery Disease

Summary: this study aims at evaluating the feasibility of ct myocardial perfusion imaging in daily clinical practice and compare it to spect perfusion imaging in order to assess sensitivity and specifity of ct myocardial perfusion imaging compared to spect.

if after the clinically indicated ccta a myocardial perfusion examination is indicated, first a single ultra low dose ct scan will be performed to look for late enhancement of potentially scarred myocardium. together with the contrast agent co-injection of the clinically indicated tracer 99mtc-tetrofosmin will be performed for later scintigraphic perfusion evaluation. after stress perfusion imaging ct rest perfusion imaging will be performed in a similar fashion. after acquisition of ct rest perfusion images scintigraphic stress and rest image acquisition will be performed as in daily clinical routine with an additional administration of 99mtc-tetrofosmin resting dose if necessary. ct stress and rest perfusion will be compared to the clinically indicated and well established spect examination.

Eligibility criteria:
inclusion criteria: * referral for cardiac hybrid imaging with ccta and spect * male and female subjects 18 years of age or older, * written informed consent by the participant after information about the project exclusion criteria: * contraindications for ccta (including renal failure with a gfr \<60ml/min/1.73m2, allergies to ionidated constrast agents) * inability to follow the examination procedure due to language barriers, mental disease, dementia etc. * pregnancy or breast feeding * known allergies to iodinated contrast agent (visipaque ®), 99mtc-tetrofosmin (myoview ®), betablockers (beloc i.v. ®) or nitrates (isoket -spray®) * hypersensitivity to adenosine * asthma bronchiale
efficacy of honan balloon in intraocular pressure reduction before phacoemulsification

Conditions: Cataract

Summary: -does honan balloon reduce intraocular pressure preoperatively?

-does honan balloon improve surgeon's satisfaction and patients' pain score when compared to no honan group?

Eligibility criteria:
inclusion criteria: * cataract patient,who plan to undergo phacoemulsification * no previous ocular surgery exclusion criteria: * one eye * high myopia * use asa or anticoagulants * history of glaucoma or ocular hypertension * uncooperative patients