Kornimate/medical-research-clean huggingface dataset:
effect of trunk stabilizing exercises on patients with median sternotomy after heart valve surgery

Conditions: Valvular Heart Disease

Summary: purpose: the aim of this study is to investigate the effect of trunk stabilizing exercises on sternal instability in patients with median sternotomy after heart valve surgery

valvular heart disease constitutes a growing healthcare problem with a general prevalence of 2%-5% and a prevalence of 13% after the age of 75 years. heart valve surgery can be a lifesaving procedure for patients with severe symptomatic heart valve disease. nevertheless, following the surgery, up to 27% of patients may require readmission within 30 days after discharge. following heart valve surgery, some patients report anxiety and worries related to readmission and reoperations, postoperative complications, and deconditioning which may prevent or delay return to work and limit activities of daily living trunk stabilizing exercises train and activate the abdominal and anterior thoracic cage muscles to assist in stabilizing the bisected sternum, thereby decreasing the undue motion in both sagittal and transverse planes during trunk movement. patients' complaints of pain and discomfort associated with sternal instability post-cardiac surgery may be managed by diminishing the degree of this undue motion between the edges of the divided sternum, and thus provides a conservative treatment for sternal instability forty female patients will be divided into two groups. group a received trunk stabilizing exercise and group b will receive routine cardiac rehabilitation; three times/week for four weeks. the outcome variables were sternal instability and sternal separation and measured before and after completion of treatment

Eligibility criteria:
inclusion criteria: 1. age between 40 and 50 years, female gender 2. hemodynamic stability 3. bmi from 25 to 29.9 kg/m2 4. they will have acute sternal instability. exclusion criteria: 1. previous thoracic surgery 2. elective and urgent coronary artery bypass surgery 3. respiratory insufficiency after surgery manifesting hypoxemia with partial pressure of oxygen in arterial blood \<60 mmhg 4. renal insufficiency with serum creatinine ≥1.8 mg/dl after surgery 5. low cardiac output syndrome with st segment elevation in multiple electrocardiogram leads, cardiac arrhythmias, or hypotension, according to the american college of cardiology foundation and american heart association 6. other medical conditions such as diabetes, uncontrolled hypertension and obesity 7. past medical history that include conditions that may have influenced the provision of physiotherapy interventions such as (severe asthma, chronic airflow limitation, bronchiectasis, ankylosing spondylitis or lumbar disc prolapse

Keywords: trunk stabilizing exercises
study of act-129968 in adult patients with seasonal allergic rhinitis

Conditions: Seasonal Allergic Rhinitis

Summary: this study will assess the efficacy and safety of different doses of act-129968 in adult patients with seasonal allergic rhinitis, due to mountain cedar pollen.


Eligibility criteria:
inclusion criteria: * males and females aged 18 to 70 years. * clinical history of symptomatic seasonal allergic rhinitis associated with mountain cedar pollen for the last two years. * adequate exposure to mountain cedar pollen. * positive skin prick test to mountain cedar allergen within 12 months of screening. * sufficient nasal symptom score during a run-in period. exclusion criteria: * non-allergic rhinitis. * bacterial or viral respiratory tract infection. * chronic respiratory disorders. * asthma requiring treatment other than inhaled short-acting beta2-agonists. * ocular infections or surgery, nasal obstruction, nasal biopsy or surgery, sinus surgery or perforation. * smoking within the last year. * ongoing or recent treatment for seasonal allergic rhinitis. * initiation of allergen immunotherapy within 6 months of screening.

Keywords: seasonal allergic rhinitis sar allergic rhinitis allergies
arthroscopic assisted lateral soft tissue release for hallux valgus

Conditions: Hallux Valgus; Hallux Valgus and Bunion

Summary: lateral soft tissue release is commonly performed as part of the surgical correction of hallux valgus. this study will look at the results form a series of patients whom have underwent the arthroscopic lateral soft tissue release.


Eligibility criteria:
inclusion: * \>18 and legally fit for consent * symptomatic hallux valgus with hva \>15 degrees exclusion: * active physical or mental disorders that could affect rehabilitation including * other conditions affecting ambulation: lower limb injury, neuromuscular problems etc. * mental incapacitation * previous hallux valgus surgery

Keywords: arthroscopy
management of patellar fractures by craniofacial mesh plate osteosynthesis augmented by screws

Conditions: Patella Fracture

Summary: patellar fractures are challenging orthopedic injuries. fractures that result in disruption of the extensor mechanism led to significant functional deficits. the goals of treatment for patella fractures include restoration of articular congruity, painless full range of motion of the knee, and recovery of extensor mechanism function. the biomechanical construct chosen to fix patellar fractures is very important because of the subcutaneous location of the patella and the high level of force transmission that occurs through the patella during flexion and extension of the knee. some studies have shown that during specific actions like walking or climbing downhill, the patella can see forces as high as 3200 n, equaling four to five times the standard body weight of a person. achieving biomechanical stability during patellar fracture fixation is imperative as the stability of fixation is tested thousands of times as the knee is put through numerous cycles of flexion and extension during the recovery period. while tension band wiring with or without -k- wire, screw, or cerclage wire augmentation the most widely accepted form of treatment for patellar fractures, plate osteosynthesis is gaining popularity for certain fracture patterns. we present below a novel form of patellar fracture fixation using matrixneuro contourable mesh plates (synthes®). made of titanium with an incredibly low profile, these plates were initially designed for use in midface and craniofacial skeletal trauma. however, we found that using these plates in treatment of patellar fractures has allowed stable fixation of complex, severely comminuted injuries the benefit of plate is adequate and stable reduction and maintenance of this reduction


Eligibility criteria:
inclusion criteria: patient with simple patella fractues more than 16 years. exclusion criteria: * open fractures * preexisting deformity * ipsilateral femoral injuries
dry needling versus graston technique in active myofascial trigger points on upper trapezius

Conditions: Trigger Points

Summary: this study will compare the effects dry needling and graston technique in active myofascial trigger points on upper trapezius. half of the study participants will receive dry needling whereas other half will receive graston technique.

this is a single blinded randomized controlled trial, will be conducted at rawal general \& dental hospital, islamabad. both dry needling and graston techniques are used to release active myofascial trigger points with different mechanism. dry needling is technique in which without any medication or injection, dry needles are inserted into hyper irritable points in muscle. graston technique is done with specially designed tools to locate knots within muscle by running the tools over the skin. this study is planned with objectives to compare both treatment techniques on active myofascial trigger points in patients with neck pain. effects of these will be measured on neck pain, range of motion, functional status and trigger points.

Eligibility criteria:
inclusion criteria: * patient with non-specific pain in neck (acute and sub-acute) * age: 20-40 years * patient agrees to use the dry needling or graston exclusively exclusion criteria: * patients that were using any medication to reduce the pain and/or have any effect in the skeleton muscle. * patient taking other treatment in the same period of research. * patients having malignancy, tuberculosis, spinal cord injury, neurodegenerative diseases radiculopathies and hematoma. * patients on anticoagulants. * patient with chronic neck pain.

Keywords: trigger area myofascial pain syndromes instrument assisted soft tissue tecnique
efficacy and safety of meteospasmyl® in irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: to assess the effectiveness of alverine citrate and simeticone on ibs symptoms according to the latest recommended design


Eligibility criteria:
inclusion criteria: * male or female ambulatory patients, aged 18-75 years * with ibs as defined by rome iii criteria exclusion criteria: * functional bowel disorder other than ibs, * underlying cause for symptomatology, which excludes ibs diagnosis, * gastro-intestinal cancer or significant gastro-intestinal surgical background, * any acute/uncontrolled systemic pathology
oxaliplatin with gemcitabine in patients with carcinoma of the urothelial tract

Conditions: Carcinoma, Transitional Cell

Summary: this is a phase ii monocentric study of oxaliplatin (ox) in combination with gemcitabine (gem; gemox) in patients (pts) with advanced/metastatic transitional cell carcinoma (tcc) of the urothelial tract.


Eligibility criteria:
inclusion criteria: * transitional cell carcinoma * histologically-proven * locally advanced unresectable or metastatic * with at least one measurable target * informed consent signed exclusion criteria: * previous chemotherapy * previous radiotherapy * performance status \>=2 * peripheral neuropathy \>=1

Keywords: carcinoma of the urothelial tract
hemorrhoidal disease in inflammatory bowel disease: a multicenter prospective cohort study

Conditions: IBD (Inflammatory Bowel Disease); Hemorrhoid; Safety; Sugery; Surgery Related Complications Rate

Summary: patients who will undergo surgery for hd after the diagnosis of ibd over a 12-month period will be enrolled across europe. primary objective of this study is to determine the safety and effectiveness of surgical treatments for hd in a large multicenter cohort of ibd patients. secondary aim is to identify factors that may affect clinical and surgical outcomes.

to date, there is no consensus in the scientific literature regarding the exact indications for surgery for hemorrhoidal disease (hd) in patients with inflammatory bowel disease (ibd). the head-ibd-ii study is a multicenter, prospective cohort designed to evaluate the safety and effectiveness of surgical treatments for hemorrhoidal disease (hd) in patients with inflammatory bowel disease (ibd). this study aims to collect contemporary, real-world data from multiple hospitals across various countries, focusing on the surgical management of hd in this unique patient population. the study will include adult patients with a confirmed diagnosis of crohn's disease or ulcerative colitis who undergo surgery for hd. the data collection process will involve detailed records of patient demographics, pre-operative status, operative techniques, and post-operative outcomes, with a specific focus on short-, medium-, and long-term surgical and clinical results. the study will track outcomes such as postoperative complications, recurrence of symptoms, ibd flare-ups, and anal continence. in addition, factors such as surgical volume, techniques employed, and individual patient characteristics will be analyzed to identify variables that may impact the outcomes. the study is designed to generate hypotheses and explore variability in current practices, thereby highlighting areas in need of further investigation through randomized controlled trials. all patient data will be collected anonymously through a secure electronic case report form (ecrf), and results will be disseminated according to the strobe guidelines for observational studies. ethical approval will be obtained from participating institutions, and all patients will provide informed consent prior to inclusion. the study is expected to improve the understanding of surgical approaches to hd in ibd patients and potentially guide future clinical recommendations.

Eligibility criteria:
inclusion criteria: * age of 18 years and above; * established diagnosis of crohn's disease or ulcerative colitis at the time of surgery for hemorrhoidal disease; * planned surgery for hemorrhoidal disease during the study period, including hemorrhoidectomy (open, close or submucosal), transanal hemorrhoidal dearterialization, hemorrhoidal laser procedure, stapled hemorrhoidopexy). exclusion criteria: * previous surgery for hemorrhoidal disease other than office-based treatments (e.g., sclerotherapy injection, rubber band ligation); * active perianal disease at the time of surgical intervention.

Keywords: head-ibd-ii hemorrhoidal disease ibd surgery
paclitaxel liposome for squamous non-small-cell lung cancer study(lipusu)

Conditions: Squamous Non-small-cell Lung Cancer

Summary: the purpose of this study is to investigate the efficacy and the safety of paclitaxel liposome and cisplatin compared with gemcitabine and cisplatin as first-line therapy in advanced squamous non-small-cell lung cancer .

the purpose of this study is to investigate the efficacy and safety of paclitaxel liposome and cisplatin compared with gemcitabine and cisplatin as first-line therapy in advanced squamous non-small-cell lung cancer .

Eligibility criteria:
inclusion criteria: 1. aged 18-75 years old, both gender; 2. ecog: 0-1; 3. squamous non-small-cell lung cancer (stage iiib or iv) confirmed by histologically or cytologically ; 4. no prior chemotherapy, biological therapy or immunotherapy; or subjects have recurrence and metastasis more than 6 months after the end of chemotherapy, but not gemcitabine or paclitaxel; 5. at least one radiographically measurable or assessable lesion on chest cg according to recist1.1 (response evaluation criteria of solid tumors); regional lymph node metastases may also be measured or assessed by imaging (mediastinal lymph nodes); 6. life expectancy of at least 12 weeks; 7. before treatment, blood tests or biochemical measurements must meet the following criteria: * white blood cell count (wbc)≥ 4.0\*10\^9/l; * neutrophil count (anc)≥ 2.0\*10\^9/l; * platelet count (plt)≥ 100\*10\^9/l; * hemoglobin (hb)≥ 100g/l; * hepatic function: serum bilirubin ≤ 1.5 times the upper normal limit,aspartate aminotransferase (ast) and alanine aminotransferase (alt) ≤ 2.5 times the upper normal limit; * renal function: creatinine ≤ 1.5 times the upper normal limit; 8. signed informed consent. exclusion criteria: 1. hypersensitivity reaction to the interventional drugs; 2. pregnant or breastfeeding; 3. women or men of childbearing age who disagree with the use of effective contraceptive measures during the study period; 4. brain metastase ; 5. uncontrolled pleural effusion in patients with squamous non-small-cell lung cancer
eating disorders with and without childhood trauma

Conditions: Eating Disorders; Stress Disorders, Post-traumatic

Summary: the combination of eds (ed) and post-traumatic sequelae of childhood trauma leads to significant impairment, suffering and represents a public health concern because it is frequently associated with role impairment, and is frequently under-treated. considering the severity of these conditions, there is a need to develop more effective treatments that are tailored to the specific needs of these patients as no conclusion has been made about the treatment of choice. to improve treatment it is critically important to study treatment effects and the mechanism of these effects.

the overall aim of the current project is; (1) to build knowledge on how to best treat patients with ed with and without childhood trauma, (2) to develop our understanding about how change happens for these patients. the investigators will do this by compare two treatment models; (1) compassion-focused therapy (cft) and (2) cognitive behavioural therapy (cbt), for eds both treatment types delivered at modum bad psychiatric center, department of ed. patients included in this randomized controlled trial will receive treatment at modum bad, satisfy dsm-v criteria for ed and half of the patients will in addition have a history of childhood trauma. a total of 86 patients who have received either cft or cbt are followed up two year after completion of the treatment. the study utilises a rich data set collected outcome measures at altogether 5 time points and process and sub-outcome measures at 13 time points. the investigators will take advantage of our established collaborative networks, both nationally and internationally and existing procedures, where all patients are assessed with the same clinical instruments based on current state-of-the-art methods.

Eligibility criteria:
inclusion criteria: * satisfying dsm-v criteria for ed and for half of the patients in addition * have a history of childhood trauma. exclusion criteria: * current suicidal risk * current psychosis * ongoing trauma (e.g. current involvement in an abusive relationship).
polycan in combination with glucosamine for treatment of knee osteoarthritis

Conditions: Osteoarthritis of the Knee

Summary: the objectives of this study is to examine the safety and eﬃcacy of black yeast beta-glucan produced from aureobusidium pulluluns sm-2001 (polycan), in combination with glucosamine in reducing knee osteoarthritis (oa) associated symptoms. this study is a double-blind, randomized, active-controlled trial conducted with 100 oa patients, aged 35-80 years using a formulated product


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of knee osteoarthritis (oa) * oa ranging from grade 1 to grade 3 by kellgren and lawrence system * agree to participate into the study exclusion criteria: * oa ranging from grade 4 by kellgren and lawrence system * allergic or contradicted with oral nsaids (meloxicam) * pregnant and breastfeeding women.
safety and effect of oral doses of 5mg or 10mg of slx-2101 for 14 days in patients with hypertension

Conditions: Hypertension

Summary: the purpose is to determine the effect of slx-2101 dosed at 5mg or 10mg for 14 days on systolic, diastolic pressures and heart rate in patients with hypertension.

1. placebo-corrected supine peripheral systolic, diastolic blood pressures and heart rate 2. 24 hour ambulatory blood pressure and heart rate 3. safety and tolerability

Eligibility criteria:
inclusion criteria: * male or female subjects between 18 and 70 years old, inclusive * moderate to severe hypertension * body weight within a body mass index of 18-32kg/m2 exclusion criteria: * the subject is receiving more than three antihypertensive agents * a history of drug abuse * exposure to a new chemical entity within 3 months prior to the first day of dosing
exercise pulmonary transit time

Conditions: Heart Failure, Diastolic

Summary: the study seeks to measure pulmonary transit time via contrast-echocardiography before and after exercise.

the ability to measure the amount of blood in the lungs using heart-ultrasound (echocardiography) can be useful to estimate how much fluid is in a patient's circulation, which can influence diagnosis and treatment of certain types of heart failure. in some patients, the amount of fluid is normal at rest, but can increase with activity and thus a diagnosis of heart failure can only be made after exercising. currently, the amount of fluid is measured invasively. we have shown that echocardiography can measure the amount of fluid in the lung circulation at rest without the need for an invasive procedure. we now seek to find out if we can make a similar measurement after exercise. if successful, the need for catheter procedures may be reduced in certain types of heart failure.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old 2. able to give informed consent exclusion criteria: 1. known allergic reaction to definity or optison ultrasound contrast 2. pregnancy/nursing - as assessed/disclosed by the participant
the relationship between normal saline infusion and acute kidney injury in heat stroke

Conditions: Heat Stroke

Summary: the goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke. the main question it aims to answer is whether limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke. participants will receive a free normal saline infusion during the emergency department according to the study design, or a restricted normal saline infusion while using sodium lactate ringer's instead. researchers will compare the normal saline infusion group and sodium lactate ringer's group to see if limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.


Eligibility criteria:
inclusion criteria: * ≥ 18 years * diagnosed as heat stroke * informed consent from patients or family members. exclusion criteria: * need immediate cardiopulmonary resuscitation * transferred from another hospital * with original end-stage renal disease or dialysis * with severe organ damage * pregnant women

Keywords: heat stroke normal saline acute kidney injury mortality
outcome of different iols in patients with and without uveitis

Conditions: Uveitis; Cataract; Inflammation; Posterior Capsule Opacification

Summary: cataract, is a clouding of the lens in the eye gradually leading to reduction of the visual acuity. in most cases it can be managed with surgery, removing the own lens and replacing it with an artificial lens, intraocular lens (iol). these lenses are made in different materials with different properties. uveitis refers to an inflammation in the iris, ciliary body and choroid. patients with this disease have an increased risk of developing cataract due to the inflammation itself and treatment with steroids. they also have an increased risk of complications during surgery and postoperatively. in this group the selection of iol might be of greater importance. the aim of this prospective randomized controlled study is to compare the outcome of hydrophobic and hydrophilic intraocular lenses in patients with and without uveitis


Eligibility criteria:
inclusion criteria: * cataract requiring surgery * ability to understand and sign consent form exclusion criteria: * extensive corneal scarring * other eye surgery less than 3 months before inclusion * unregulated glaucoma * active uveitis (increased inflammation and treatment less than 3 months before inclusion) * intraoperative complications (capsular tear or vitreous loss)