Kornimate/medical-research-clean huggingface dataset:
bidimensional rectal-water contrast-transvaginal ultrasonography (2d-rwc-tvs) versus 3d-rwc-tvs in the diagnosis of rectosigmoid endometriosis

Conditions: Endometriosis, Rectum; Endometriosis of Colon

Summary: an accurate diagnosis of the presence, location and extent of the rectosigmoid endometriosis is of paramount importance for the clinicians in order to inform the patients on the potential surgical or medical treatments. it is well established that transvaginal ultrasonography is the first-line investigation in patients with suspicion of deep infiltrating endometriosis. an improvement in the performance of transvaginal ultrasonography in diagnosing rectosigmoid endometriosis may be obtained by using rectal water contrast during transvaginal ultrasonographic scan.


Eligibility criteria:
inclusion criteria: * pain and intestinal symptoms suggestive of rectosigmoid endometriosis exclusion criteria: * previous surgical diagnosis of intestinal endometriosis * previous radiological diagnosis of intestinal endometriosis (based on magnetic resonance or double-contrast barium enema) * history of colorectal surgery (except appendectomy) * contraindications to bowel preparation or computed colonography (such as non-compliant patients and rectal malformations) * previous bilateral ovariectomy * psychiatric disorders
essilor® stellest® lenses multicentre european study (slomes)

Conditions: Myopia

Summary: the goal of this post-market clinical follow up study is to demonstrate the efficacy, safety, acceptability, and quality of life implications of essilor® stellest® spectacle lenses in slowing myopia progression in european children and adolescents. participants will receive essilor® stellest® at inclusion visit and will be asked for a full time wear (\>12 hours daily) for 24 months. the primary endpoints are the change in axial length and cycloplegic autorefraction from baseline to 24 months compared to expected change based on axial length and refraction centile positions at baseline.

the trial design is a multicentre, european, prospective, interventional study with single group assignment. the investigational medical device essilor® stellest® is a ce marked, myopia control spectacle lens. the trial period for all participants is 24 months. the recruiting period is 6 to 9 months depending on countries / sites for a total of 150 participants (50 in ireland, 75 in france and 25 in the netherlands). the secondary objectives are: * to evaluate the acceptability of essilor® stellest® spectacle lenses in slowing myopia progression. * to evaluate the quality-of-life implications for children and adolescents. * to evaluate the safety of essilor® stellest® spectacle lenses in slowing myopia progression. * to evaluate the effect of essilor® stellest® spectacle lenses on choroidal thickness.

Eligibility criteria:
inclusion criteria: 1. - myopia as determined by cycloplegic autorefraction as follows: * each meridian ser of plano to - 8;00 d in each eye * astigmatism \< 2.50 d * anisometropia ≤ 1.50 d 2. - monocular corrected va of at least 0.2 logmar in both eyes 3. - age: 6 - 16 years old, inclusive at the time of inclusion 4. - ability to understand treatment and give valid assent 5. - ability to comply with the protocol to get reliable study measurements exclusion criteria: 1. - concomitant or previous therapies for myopia 2. - eye diseases/conditions: * strabismus by cover test at near or distance * any ocular disease that would influence refractive development e.g. retinal disease, cataract, ptosis * any systemic or neurodevelopmental conditions that may influence refractive development 3. - use of ocular or systemic medication which may affect myopia progression or visual acuity through known effects on retina, accommodation, or significant elevation of intraocular pressure 4. - participation in another study which may influence vision or interfere with study assessments 5. - myopia onset before 5 years of age 6. - contact lens wearers
a study of mirikizumab (ly3074828) in pediatric participants with moderately to severely or active ulcerative colitis

Conditions: Ulcerative Colitis

Summary: the main purpose of this study is to investigate efficacy, pharmacokinetics and safety of the drug in pediatric participants with moderately to severely active ulcerative colitis (uc).

participants who complete the study will have the option to enter the long-term extension study i6t-mc-amaz (amaz).

Eligibility criteria:
inclusion criteria: * males or females weighing ≥10 kg and ≥2 and \<18 years old at the time of consent for screening. * have moderate to severe uc. * have failed corticosteroids, biologics, (for example, anti-tumor necrosis factor (tnf) antibodies or anti-integrin antibodies), immunomodulators (for example, azathioprine, thiopurines or methotrexate) or janus kinase (jak)-inhibitor treatment. * have uc at least 3 months in duration before baseline, which includes endoscopic evidence of uc corroborated by a histopathology report. exclusion criteria: * have crohn's disease, inflammatory bowel disease unclassified, ulcerative proctitis or primary sclerosing cholangitis. * have immune deficiency syndrome. * previous bowel resection or intestinal surgery. * evidence of toxic megacolon. * history or current evidence of cancer of the gastrointestinal tract.
fasenra scei for long-term use

Conditions: Asthma

Summary: the purpose of the investigation is to confirm the safety and efficacy under the post-marketing actual long-term use of fasenra subcutaneous injection 30 mg syringe.

the purpose of the investigation is to confirm the followings under the post-marketing actual long-term use of fasenra subcutaneous injection 30 mg syringe. 1. detection of unexpected adverse drug reactions 2. to grasp development of adverse drug reactions 3. to grasp contributing factors possibly having an impact on the safety and efficacy 4. development of key investigational safety specification (serious infection).

Eligibility criteria:
inclusion criteria: -the evaluable patients treated with fasenra for the first time due to "bronchial asthma (only the patients with intractable bronchial asthma which could not be controlled with the existing therapy). exclusion criteria: -no past history of hypersensitivity to the components of fasenra.

Keywords: fasenra benralizumab bronchial asthma
coronary artery disease (cad) in patients hiv-infected

Conditions: HIV Infections

Summary: hiv-infected patients with intermediate-high risk have a high prevalence of cad and a substantial proportion of obstructive cad. degree of stenosis is associated with immunoactivation (lymphocyte and monocyte) and microbial translocation


Eligibility criteria:
inclusion criteria: hiv-infected patients \>= 45 years with 2 or more cv risk factors currently on art hiv-rna \ = 12 months (one blip allowed) asymptomatic regarding cardiac symptoms (chest pain, syncope, dyspnea) stable art for more than 6 months exclusion criteria: * sign of coronary pathology (chest pain, syncope, dyspnea). * atcd of allergy to iv contrast agents * chronic inflammatory disease other than hiv * subject to a measure for the protection of justice
clinical investigation of the visual outcomes and safety of a trifocal intraocular lens (iol) in a korean population

Conditions: Cataract; Presbyopia

Summary: the purpose of this study is to confirm the effectiveness of the investigational lens in a korean population, especially for visual performance, quality of vision, and subject satisfaction with the visual outcome, as well as the safety of the lens. this trial will be conducted in korea.

both eyes of a subject must require cataract surgery to qualify for enrollment into this study. subjects participating in the trial will attend a total of 9 study visits over a 4-5-month period. of these 9 visits, 1 is preoperative, 2 are operative, and the remaining 6 are postoperative visits. primary endpoint data will be collected at the month 3 visit (day 90-120 post second eye implantation). the second eye implantation will occur 2-30 days after the first implantation.

Eligibility criteria:
inclusion criteria: * requires cataract extraction in both eyes * clear intraocular media other than cataracts in both eyes * calculated lens power between +16.0 and +24.0 diopter (d) * preoperative or expected postoperative regular corneal astigmatism of \< 1.00 d. exclusion criteria: * pregnant or lactating * any clinically significant corneal abnormality, per the investigator's expert medical opinion * previous corneal transplant; previous ocular trauma; previous refractive surgery * history of, concurrent, or predisposition to retinal conditions, such as diabetic retinopathy, diabetic macular edema, or macular degeneration.

Keywords: korea trifocal panoptix bilateral implantation cataract prospective single arm acrysof model tfnt00
peginterferon alfa-2b treatment in hbeag(+) chronic hepatitis b patients based on interferon gene mutation and receptor detection

Conditions: Chronic Hepatitis b

Summary: the study is to observe the anti-hbv therapeutic effects of peginterferon alfa-2b in chronic hepatitis b patients with e antigen positive based on the detection of interferon gene mutation (ifna2 p.ala120thr) and interferon receptor (ifnar2) detection.

patients with e antigen positive chronic hepatitis b were enrolled in the study. age, sex, symptoms (e.g., fever, fatigue, poor appetite, jaundice) were recorded in the study. we also observed the laboratory test results including the levels of white blood cells (wbc), red blood cells (rbc), hemoglobin (hgb), platelet (plt), alanine transaminase (alt), aspartate transaminase (ast), hepatitis b surface antigen (hbsag), hepatitis b e antigen (hbeag), hepatitis b e antibody (hbeab), and hepatitis b virus (hbv) dna; detection of gene mutation (ifna2 p.ala120thr), levels of interferon receptor (ifnar2).

Eligibility criteria:
inclusion criteria: 1. chronic hepatitis b patients who should receive anti-hbv therapy according to guideline and are willing to receive interferon therapy; 2. hepatitis b e antigen positive. exclusion criteria: 1. patients received anti-hbv therapy in the past 6 months; 2. patients with liver cirrhosis or hepatocellular carcinoma or other malignancies; 3. patients with other factors causing active liver diseases; 4. pregnancy or lactation women; 5. patients with hiv infection or congenital immune deficiency diseases; 6. patients with severe diabetes, autoimmune diseases, other important organ dysfunctions and other serious complications. 7. patients with other reasons not suitable to receive interferon therapy.

Keywords: chronic hepatitis b peginterferon alfa-2b interferon gene mutation interferon receptor
success rates for management of separated instruments

Conditions: Teeth, Endodontically-Treated

Summary: the study compares the prognosis of cases of separated instruments in canals with type ii vertucci's classification treated with conservative approach

teeth with type ii vertucci root canal configuration are having more incidence of instruments separation due the presence of an s-type (double curve). the aim of this study is to compare the outcome of minimally invasive approach (mia), retaining the separated in one root canal, cleaning and shaping of portals of entry of the two canals and portal of exit of both canals through the other patent canal, in comparison to the outcome of retrieval of the broken instrument by ultrasonics retrieval techniques (urt)

Eligibility criteria:
inclusion criteria: * presence of separated instrument in a root with a vertucci's type ii configuration (the level of the si was evaluated using cbct scans) * age range 35-55 years * teeth having a baseline periapical lesion (pai score ≥2) in the affected root exclusion criteria: * • patients who refused to undergo radiographic follow-up. * pregnant females. * patients suffered from a systemic disease. * teeth with lesions connected to adjacent teeth. * teeth with root fractures or perforations. * teeth with lesion communicating with the alveolar crest. * patients with generalized chronic periodontitis or teeth that need periodontal surgery prior to coronal restorations due to marginal deficiency * teeth with damaged or resorbed peri- apex * teeth that were treated with a fiber post and teeth with canal curvature more than 25 degrees
extra-pulmonary clinical manifestations of influenza virus and respiratory syncitial virus infections

Conditions: Influenza; Respiratory Virus Syncitial; Extra-respiratory

Summary: the purpose of this study is to describe extra-pulmonary clinical manifestations of influenza virus and respiratory syncitial virus infections in hospitalized adults at a french university hospital.

influenza virus and respiratory syncitial virus (rsv) could be responsible for severe infections. although flu was primarily considered as limited to the respiratory system, clinical reports suggest its association with organ involvement outside of the respiratory tract. the aim of the study is to describe extra-pulmonary complications due to influenza virus and rsv in hospitalized patients from november 2018 to april 2019 and november 2019 to april 2020 in a french university hospital.

Eligibility criteria:
inclusion criteria: * hospitalized adults ≥18 years old * flu or rsv infection confirmed by multiplex qpcr on nasal swab * oral non-opposition exclusion criteria: * no health insurance * co-infection with viruses other than influenza or rsv
educating providers about lung screening

Conditions: Lung Cancer

Summary: we are conducting a randomized trial to compare the health disparities module to an existing provider module on lung cancer screening to evaluate the impact on primary care providers' knowledge, attitudes, and lung cancer screening referrals of african american and white patients.

we are conducting a randomized trial of two online, provider-facing education modules regarding lung cancer screening and smoking cessation. we will accrue 70 medstar primary care providers (pcp). the baseline survey will incorporate items regarding lung cancer screening knowledge, providers' attitudes towards lung cancer screening, lung cancer screening ordering practices and provider characteristics. at the end of the baseline survey, pcps will be randomly assigned to the luca + health disparities or luca only. pcps will be asked to complete the intervention and the post-test within 1 week of randomization. the post test will cover knowledge of lung cancer screening, attitudes and opinions toward lcs. to assess pcp lung cancer screening ordering practices, we will review the medconnect electronic health record (ehr) to compare the two study groups post-randomization on the number of orders made for lcs.

Eligibility criteria:
inclusion criteria: * medstar provider (attending or resident physician, physician's assistant, or nurse practitioner) * english speaking * ability to provide meaningful consent * ability to provide last two digits of npi. exclusion criteria: * n/a

Keywords: lung cancer screening provider education health disparities
pathway from functional disability to antimicrobial resistance in nursing home residents

Conditions: Multi-antibiotic Resistance

Summary: multidrug-resistant organisms (mdros) are endemic in nursing homes (nhs) with prevalence rates surpassing those in hospitals. the aim of the study is to design and evaluate the effectiveness of a multi-component intervention to reduce new acquisition of mdros in nh residents. the intervention will incorporate resident-level, environmental, and caregiver based strategies. using a cluster-randomized study design, three nhs will be randomized to the intervention group and three to the control group. control nhs will be allowed to continue standard infection prevention practices. nursing homes will serve as the unit of allocation. analyses will be performed both at the resident and the cluster level. the primary outcomes of the study are reduction in mdro prevalence, and reduction in new mdro acquisition .

the nh intervention will incorporate resident-level, environmental, and caregiver based strategies, including: a. standard precautions and hand hygiene for care of all residents. enhanced barrier precautions including hand hygiene, glove use, and gown use for healthcare workers (hcw) when providing activities of daily living (adl) assistance for residents at highest-risk (caregiver intervention); b. hand hygiene education to residents and families (resident-level intervention); c. standardized bathing practices including using chlorhexidine-based cloths to reduce resident mdro colonization (resident-level intervention); d. standardized environmental protocol and education to reduce contamination on inanimate objects and surfaces (environmental intervention); e. feedback monthly of facility-level microbial data and new mdro acquisition rates to infection preventionists, front-line healthcare personnel, and facility leadership (facility intervention).

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * residing in a participating nh facility * provided informed consent for participation exclusion criteria: * receiving end-of-life care * non-english language speaking

Keywords: multidrug-resistant organisms nursing home post-acute care long-term care infection control
comparison of fdg pet and bone scintigraphy/labelled leukocyte/gallium scintigraphy in diabetic foot osteomyelitis

Conditions: Diabetic Foot Infection

Summary: diabetic foot osteomyelitis is a common and serious complication of diabetes. while the diagnosis of soft tissue infection can be made with simple physical examination in most cases, bone involvement can be harder to diagnose, often requiring medical imaging. in addition to conventional radiological examinations (x-ray and mri) nuclear medicine procedures can also provide important physiological information in these patients. these procedures include triple phase bone scan combined with gallium scintigraphy or a combination of labelled leukocyte scintigraphy and bone marrow scintigraphy using sulfur colloid. these procedure, while they provide useful physiological information, are time consuming, generally requiring at least 2 separate image acquisition on separate days, and can be costly. 18f-fdg is a glucose analog that can be used for pet imaging. in addition to its application in oncology, the literature has shown that fdg can be used to investigate a wide variety of inflammatory and infectious conditions, including diabetic foot infections. the aim of this study is to compare the usefulness of fdg pet imaging versus "conventional" nuclear medicine (either bone scan and gallium scintigraphy or labelled leukocytes and sulfur colloid scintigraphy) in patient with suspected diabetic foot osteomyelitis.


Eligibility criteria:
inclusion criteria: * diabetic patient with suspected diabetic foot osteomyelitis referred for nuclear medicine examination (bone scan and gallium or labelled leukocytes). * being treated or followed by a physician at chum exclusion criteria: * pregnant woman * breastfeeding patient * claustrophobia/patient unable to complete imaging procedure
evaluation of an open-source speech-processing platform

Conditions: Hearing Loss, Sensorineural

Summary: determining acceptability and usability of a wearable open-source speech processing platform (master hearing aid) developed for hearing-aid research

part 1 speech perception tests. you will hear words and sentences under a variety of listening conditions and be asked either to either repeat them or to select what you heard from a set of options. you will also answer a few questions about the speech and the background noise. the goal is to determine the ability of the most recent version of the device to deliver good quality speech that is comfortable and understandable over a range of conditions that are representative of everyday listening. part 2. suitability and acceptability. you will be asked to respond to a short structured interview about the device. if the device has reached a wearable stage, you will wear it outside the laboratory while engaging in discussion with one of the researchers before completing the interview. the goal is to obtain the opinions of persons with hearing loss about the device itself, and about their willingness to wear it as a hearing aid in their everyday life, if they were to be involved in a research study. part 3 is a focus-group session with about 10 hearing-aid users, some of whom will have participated in parts 1 and 2. topics will deal with hearing aids in general and about the current version of the experimental device. discussion will be recorded for later transcription and analysis. the goal is to gain the perspective of hearing-aid users about hearing aids, hearing-aid research, and the acceptability of this experimental device for field research.

Eligibility criteria:
inclusion criteria: - sensorineural hearing loss exclusion criteria: * cognitively challenged * legally blind

Keywords: hearing aid
high-intensity versus low-intensity laser acupuncture in chronic, non-specific low back pain

Conditions: Chronic Nonspecific Low-back Pain

Summary: the purpose of this study is to investigate the efficacy of high-intensity laser acupuncture versus low intensity laser acupuncture on peak torque of trunk extensors, fatigue of trunk extensors, back pain, rom and function in patients with chronic nonspecific low back pain (cnlbp).

chronic nonspecific low back pain is a type of persistent back pain that affects people of all ages and contributes to the global disease burden (cnlbp). the major objective of treatment is to lessen pain and its aftereffects. one noninvasive, targeted light therapy for treating musculoskeletal disorders is low-intensity laser therapy (lllt). it has analgesic, anti-inflammatory, muscle-relaxant, and tissue-repair properties. additionally, lilt has been demonstrated to relieve generalized lower back pain. another light therapy that is painless and noninvasive, high-intensity laser therapy (hilt), stimulates tissue while delivering analgesic, anti-inflammatory, and anti-edematous benefits. it has been demonstrated that acupuncture, a popular complementary therapy, can relieve musculoskeletal pain and increase muscle strength.to date, however, there has been limited investigation into the effects of high- versus low-intensity laser acupuncture on cnlbp. thus, the current study will be conducted to explore the efficacy of hilt versus lill on peak torque of trunk extensors, fatigue of trunk extensors, back pain, rom and functional disability in patients with chronic, nonspecific low back pain.

Eligibility criteria:
inclusion criteria: 1. the patients had cnslbp with age from 20 to 40 years from both genders. 2. patients will be referred from an orthopedist with diagnosis of chronic low back pain without underlying pathological causes. 3. the patients with chronic nonspecific low back pain more than 3months. minimum pain intensity of 30 mm on the visual analogue scale (vas) for pain, which ranges from 0 to 100 mm. 4. patients with normal bmi ranges between 18.5:24.9 kg/m2. 5. the study populations must be willing to participate in the study exclusion criteria: 1. neurological, infectious diseases and systemic illness such as rheumatologic diseases,systemic lupus erythematosus, diabetes mellitus type i or ii. 2. psychiatric/mental deficit. 3. patients who had a previous surgical history (within 6 months) will also excluded. 4. participation in other treatment within the previous 3 month. 5. pregnancy. 6. history of spinal fracture, tumor, osteoporosis

Keywords: low back pain high-intensity laser acupuncture low-intensity laser acupuncture peak torque fatigue functional disability