Kornimate/medical-research-clean huggingface dataset:
the neural substrates for working memory training

Conditions: Rehabilitation; Working Memory

Summary: this study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.


Eligibility criteria:
inclusion criteria: * right handedness * diagnosis of traumatic brain injury or stroke * course of disease within one year * the score of moca test \> 24 * able to understand instructions exclusion criteria: * aphasia, unilateral spatial neglect, agnosia, apraxia * hearing impairment or visual impairment * history of taking psychiatric drugs
physician-patient communication about breast cancer-related internet information and its effect on patient satisfaction and anxiety

Conditions: Breast Cancer

Summary: the purpose of this study is to learn about how patients who have looked up cancer-related information on the internet talk with their doctors. we are interested in these conversations even if the patients do not think they will talk about the information with their doctor during their visit. we will audio record doctor-patient visits and listen to these recordings to learn about how patients who have looked up cancer-related internet information talk to their doctors and how their doctors talk to them. we will also give patients questionnaires before and after their appointments to learn about what they think about communicating with their doctors.


Eligibility criteria:
inclusion criteria: subject inclusion criteria for patients * female * diagnosis of breast cancer * pre-surgery (\*for breast surgeon patients only) * report that they have read breast cancer-related internet information since their diagnosis with breast cancer. * provide informed consent subject inclusion criteria physicians * breast surgeon or breast medical oncologist * agree to participate in study and one of 10 selected participants * provide inform consent exclusion criteria: exclusion criteria for patients * less than 21 years of age * cognitive or physical impairment rendering patients incapable of providing informed consent to participate in the study * as the measures and coding system are all written in english, subjects who are not fluent in english will be excluded. exclusion criteria for physicians * none

Keywords: communication internet physician patient 08-079
integrative analysis of large-cell lung cancer

Conditions: Lung Cancer

Summary: integrative analysis of lclc

the investigators will analyzed proteomes of paired normal lung tissues and lclc with or without liver metastasis, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (snp) array profiling for triplets, each comprising normal lung tissue, primary lclc carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of lung cancer characterized previously by the cancer genome atlas (tcga) to conduct integrated proteogenomic analyses.

Eligibility criteria:
inclusion criteria: * age ≤ 75 years with histologically proven lclc * no severe major organ dysfunction * world health organization (who) performance status of 0 or 1 * no prior cancer chemotherapy exclusion criteria: * age ≥ 76 * severe major organ dysfunction * who performance status of \>1 * prior cancer chemotherapy

Keywords: lclc; integrative analysis; metastasis
apixaban for the acute treatment of venous thromboembolism in children

Conditions: Venous Thromboembolism

Summary: to assess the safety and descriptive efficacy of apixaban in pediatric subjects requiring anticoagulation for the treatment of a vte.


Eligibility criteria:
inclusion criteria: 1. birth to \<18 years of age with a minimum weight of 2.6 kg at the time of randomization. 2. presence of an index vte which is confirmed by imaging. 3. intention to manage the index vte with anticoagulation treatment for at least 6 to 12 weeks. 4. subjects able to tolerate oral feeding, nasogastric (ng), gastric (g) feeding and are currently tolerating enteric medications, as per investigator's judgement. exclusion criteria: 1. anticoagulant treatment for the index vte for greater than 14 days prior to randomization. neonates that are enrolled into the pk cohort must be on a minimum of 5 days and a maximum of 14 days soc anticoagulation prior to randomization. neonates that are enrolled into the post pk cohort may receive soc anticoagulation for up to 14 days prior to randomization. 2. thrombectomy, thrombolytic therapy, or insertion of a caval filter to treat the index vte. 3. a mechanical heart valve. 4. active bleeding or high risk of bleeding at the time of randomization. 5. intracranial bleed, including intraventricular hemorrhage, within 3 months prior to randomization. 6. abnormal baseline liver function at randomization. 7. inadequate renal function at the time of randomization. 8. platelet count \<50×109 per l at randomization. 9. uncontrolled severe hypertension at the time of randomization. 10. use of prohibited concomitant medication at the time of randomization. 11. female subjects who are either pregnant or breastfeeding a child. 12. use of aggressive life-saving therapies such as ventricular assist devices (vad) or extracorporeal membrane oxygenation (ecmo) at the time of enrollment. 13. unable to take oral or enteric medication via the ng or g tube. 14. known inherited or acquired antiphospholipid syndrome (aps). 15. known inherited bleeding disorder or coagulopathy with increased bleeding risk (eg, hemophilia, von willebrand disease, etc.)

Keywords: vte, thromboembolism, thrombosis, embolism, apixaban, eliquis
effect of hyperglycemia on microvascular perfusion in healthy adults

Conditions: Vascular Stiffness; Insulin Sensitivity

Summary: the investigators are studying the effects of hyperglycemia on vascular function and insulin sensitivity on healthy adults

the investigators will study 22 healthy subjects (18-35 yrs) four times as follows: 1. saline + octreotide + euglycemia; 2. octreotide + hyperglycemia; 3. octreotide + hyperglycemia + insulin clamp and 4. octreotide + euglycemia + insulin clamp. the sequence of admissions will be assigned randomly. the investigators will assess function in conduit (pulse wave velocity-pwv, augmentation index-ai and flow-mediated dilation-fmd), resistance (post-ischemic flow velocity-pifv) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-ceu) vessels. this work will: a) identify whether vascular stiffness and indices of no action are impaired throughout the arterial tree with hyperglycemia.

Eligibility criteria:
inclusion criteria: * healthy with no chronic illness * age 18-35 * normal bmi (18-25) * normal screening labs or no clinically significant values exclusion criteria: * first degree relative with type 2 diabetes * smoking presently or in the past 6 months * medications that affect the vasculature * overweight or other indications of insulin resistance * elevated ldl cholesterol \> 160 * elevated bp \> 140/90 * history of congestive heart failure, ischemic heart disease, severe pulmonary disease, liver or kidney disease, bleeding disorders * any vascular disease such as myocardial infarction, stroke, peripheral vascular disease * presence of an intracardiac or intrapulmonary shunt (we will screen for this by auscultation during the physical exam by pi). * pregnant or breastfeeding. * known hypersensitivity to perflutren (contained in definity)
the importance of lateral internal sphincterotomy incision: parallel or vertical

Conditions: Anal Fissure

Summary: the purpose of this study is to determine effective incision type for the treatment of chronic anal fissures.

the lateral internal sphincterotomy (lis) technique is considered the optimal surgical treatment for chronic anal fissures (cafs); however, questions remain regarding the best technique. the present study investigated whether the type of anoderm incision (vertical or parallel to the anus) affected wound healing, wound-related complications, incontinence and recurrence rates in caf patients undergoing open lis.

Eligibility criteria:
inclusion criteria: * patients undergoing open lateral internal sphincterotomy for chronic anal fissure exclusion criteria: * younger than 18 and older than 65 years of age, patients who had undergone no previous medical treatment, patients with a history of perianal interventions, patients with inflammatory bowel disease, diabetic patients, patients on steroids and immunosuppressives, patients with collagen tissue diseases, mentally retarded patients and patients with malignant disorders.

Keywords: lateral internal sphincterotomy anal fissure surgical technique incision wound healing
intravenous immunoglobulin for unverricht-lundborg disease.

Conditions: Unverricht-Lundborg Disease

Summary: single patient randomized double blind trial to assess whether intravenous immunoglobulin can improve the clinical outcome of a case suffering from unverricht-lundborg disease.

single patient randomized double blind trial to assess whether intravenous immunoglobulin can improve the clinical outcome of a case suffering from unverricht-lundborg disease (clinical and genetic diagnosis). the patient was randomized to be treated with intravenous immunoglobulin or placebo 1:1 (crossover) once a month for at least one year. main objective: improvement of the action myoclonus. secondary objectives: improvement in the overall score and in individual sections of the unified myoclonus rating scale at one year; patient preferences based on results at the end of the trial. the first analyst was scheduled at one year from the start of the trial. the program was to discuss the patient's analysis data and to let the patient decide in three possible ways: to continue the trial, to continue treatment with immunoglobulins, to suspend the treatment. depending on the decision, it was planned to follow the patient throughout the year after the analysis, at least for one year.

Eligibility criteria:
inclusion criteria: * malattia di unverricht-lundborg (genetic diagnosis) exclusion criteria: * contraindications to intravenous immunoglobulin

Keywords: unverricht-lundborg disease progressive myoclonus epilepsy pharmacoresistant epilepsy
empowered relief for youth

Conditions: Chronic Pain; Musculoskeletal Pain; Fibromyalgia; Neuropathic Pain; Complex Regional Pain Syndromes; Abdominal Pain

Summary: the purpose of this pilot study is to examine the feasibility and preliminary efficacy of empowered relief for youth with chronic pain (er-y). er-y is a single-session pain management class for youth focused on pain science education and teaching self-regulatory skills for pain management based on the evidence-based adult er class. feasibility and acceptability of er-y will be assessed post-class. preliminary efficacy will be assessed by administering surveys at baseline, 4-weeks, 8-weeks, and 12-weeks post class.

the current proposed, single-arm, uncontrolled pilot study will determine a) feasibility of er-y in youth with chronic pain, b) patients' perceptions and satisfaction of the er-y class and c) preliminary efficacy to inform the design of a subsequent randomized controlled trial.

Eligibility criteria:
inclusion criteria: * age at least 10 years old to 18 years * diagnosis of chronic pain * english speaking exclusion criteria: * diagnosis of neurological conditions such as seizures, cerebral palsy, developmental delay * severe affective disorder (e.g., severe depression/ anxiety) from medical record review.
adapting fams to optimize cgm use among emerging adults with type 1 diabetes

Conditions: Type 1 Diabetes

Summary: the goal of this clinical trial is to evaluate the efficacy of an adapted fams (family/friend activation to motivate self-care) intervention on cgm use among study participants who are cgm users. we will leverage the infrastructure of an niddk-funded rct evaluating fams-t1d among n=280 emerging adults with t1d who have elevated hemoglobin a1c or elevated diabetes distress (nct05820477). we anticipate at least 50% using cgm to be included in these analyses.

fams (family/friend activation to motivate self-care) is a mobile phone-delivered intervention, based on family systems theory, which helps adults with diabetes set behavioral goals and improve support received from friends and family for goal success. fams includes monthly phone coaching and text message support by fams coaches for the person with diabetes (pwd) and the option to enroll a support person (sp) to receive automated texts tailored to the self-care goals the person with t1d sets in coaching sessions. adaptations specific to cgm include the option to set cgm use goals in coaching (and receive associated text support) and skill-building exercises during coaching to support data sharing relationships (e.g., establishing, setting and adjusting ground rules about communication). within the fams-t1d rct (nct05820477), we will test effects of fams-t1d on cgm use use relative to enhanced treatment as usual. we will evaluate effects on cgm use from baseline to post-intervention (6 months) as the primary endpoint. study start date for the nested trial (nct05854069) is the enrollment date of the first participant using a cgm. since the goal of this trial is to assess effects of the adapted fams intervention on cgm use, the date participant cgm usage was confirmed is considered the enrollment date.

Eligibility criteria:
inclusion criteria: persons with diabetes * ages 18-24 * have a diagnosis of t1d and has been taking insulin for at least one year * comfortable sending and receiving texts * can speak, read, and write in english * meets one of the following two criteria: 1) has a most recent a1c value in the ehr that is 7.5% or higher (or missing) or 2) screen positive for diabetes distress on the two-item diabetes distress screen (dds-2) * using a continuous glucose monitor (cgm) support persons * age 18 or older * can speak, read, and write in english or spanish * comfortable sending and receiving texts exclusion criteria: persons with diabetes * has a condition that would prohibit study completion (intellectual disability, blindness or auditory limitations, severe mental illness) * plans to live outside the country during the study period support persons * shares a phone with the person with diabetes * plans to live outside of the country during the study period

Keywords: continuous glucose monitor social support goal setting diabetes distress hemoglobin a1c time in range emerging adults family support text message mobile health
efficacy and safety of jia shen tablets in chronic heart failure

Conditions: Heart Failure

Summary: evaluate the efficacy and safety of jia shen tablets in patients with chronic heart failure.


Eligibility criteria:
inclusion criteria: * age 40-79 years, either sex; * meet the diagnostic criteria for chd and chf; * meet the tcm differentiation criteria of yang qi deficiency and blood stasis in chf; * class ⅱ to ⅲ for nyha functional classification; * willing to provide written informed consent. exclusion criteria: * chf with acute exacerbation or intravenous drug therapy; * received cardiac resynchronization therapy (crt) or other heart failure devices; * within 3 months before randomization, acute coronary syndrome（acs）, stroke or transient ischemic attack（tia） occurred or received cardiac revascularization (pci, cabg); * plan to undergo cardiac revascularization (pci, cabg) or cardiac resynchronization therapy (crt) during the trial period; * severe arrhythmias \[such as persistent atrial fibrillation, permanent atrial fibrillation, ventricular tachycardia, second-degree type ii or higher sinus or atrioventricular block without pacemaker placement, qt interval (qtc) exceeding 480 ms after heart rate adjustment according to fridericia's formula, or known history or symptoms of long qt syndrome\]; * severe hypertension (systolic blood pressure ≥180mm hg or diastolic blood pressure ≥110mm hg) or hypotension (systolic blood pressure \< 90 mmhg); * heart failure caused by other cardiovascular diseases such as congenital heart disease, severe stenosis or insufficiency of heart valves, cardiomyopathy (e.g. hypertrophic obstructive cardiomyopathy, restrictive cardiomyopathy, dilated cardiomyopathy, alcoholic cardiomyopathy), moderate pericardial effusion, constrictive pericarditis, and infective endocarditis; * combined with liver, kidney, hematopoietic system and other serious primary diseases, alanine aminotransferase (alt) or aspartate aminotransferase (ast) more than 3 times the upper limit of local laboratory normal value, the estimated glomerular filtration rate (egfr) \ 5.5 mmol/l or hemoglobin (hb) \< 90 g/l; malignant tumors, severe neuroendocrine system diseases and mental diseases; * pregnant or lactating; * participating in other interventional clinical studies within 1 month before screening; * allergic constitution, or allergic to chinese medicines of jia shen tablets (such as periploca sepium, salvia miltiorrhiza, etc.); * the investigator determines that the patient is unable to complete the study or comply with the requirements of the study.
impact of maxigesic on delirium after minimally invasive lung surgery in elderly patients

Conditions: Delirium; Aged; Lung Neoplasms; Robotic Surgical Procedures; Thoracic Surgery, Video-Assisted

Summary: the primary aim of this interventional study is to investigate the impact of perioperative administration of maxigesic (combination of acetaminophen and ibuprofen) on delirium after minimally invasive lung surgery in elderly patients. the maxigesic group receives a total of 5 doses of maxigesic (20mg/kg, maximum dose per serving: 1g) every 6 h from immediately after anesthesia induction. the control group receives the same volume of normal saline. researchers compare the incidence and severity of postoperative delirium for 5 days after surgery.


Eligibility criteria:
inclusion criteria: * patients aged 65 years or older undergoing minimally invasive lung lobectomy or segmentectomy exclusion criteria: * hypersensitivity to the main ingredients and additives of maxigesic * hypersensitivity to aspirin or nonsteroidal anti-inflammatory drugs (nsaids) * alcoholism / alcohol intoxication * severe hematological abnormalities * bleeding tendency (e.g., spontaneous bleeding) * severe hepatic dysfunction (ast, ast ≥2.5 \* upper normal limit(unl) or total bilirubin ≥3.0 mg/dl) * severe renal dysfunction (egfr \<30 ml/min/1.73m2 or dialysis) * severe heart failure (left ventricle ejection fraction \<30%) * uncontrolled hypertension(htn) (systolic blood pressure \>180 mmhg) * symptomatic asthma in need of treatment * anticoagulants or antiplatelet agents are maintained for up to 5 days before surgery * barbiturates or tricyclic antidepressants (tcas) * high-dose methotrexate (mtx) for cancer treatment * preoperative cognitive impairment, dementia, or delirium * inability to understand the research and instructions for this study

Keywords: postoperative delirium elderly minimally invasive surgery lung segmentectomy lung lobectomy
hypertonic versus isotonic saline irrigations for chronic rhinosinusitis

Conditions: Chronic Rhinosinusitis (Diagnosis)

Summary: the study aims to determine the safety and efficacy of buffered hypertonic (1.8%) saline nasal rinses as compared to isotonic saline nasal rinses in patients with chronic rhinosinusitis (crs). evidence from basic science research suggests that hypertonic solutions may have beneficial effects over isotonic saline rinses; however prior clinical studies on this topic have been inconclusive and limited due to highly variable inclusion criteria, large variability in the volume and concentration of irrigation solution, and inconsistent outcome measures. the goal of the study is to utilize a cross over study design to directly compare the impact of two different types of saline irrigation. primary aim: compare the efficacy of buffered hypertonic saline irrigations to buffered isotonic saline irrigations on patient reported outcome measures of chronic rhinosinusitis symptoms and nasal obstruction in patients with crs. based on in vivo data and prior clinical studies, the investigators expect participants will experience greater symptom improvement with hypertonic saline rinses as compared to isotonic saline irrigations. hypothesis: participants will have greater improvement in patient reported outcome measures (snot-22 and nose) when using buffered hypertonic sinus irrigations as compared to buffered isotonic saline irrigations.


Eligibility criteria:
inclusion criteria: 1. diagnosis of chronic rhinosinusitis with or without polyposis based on the criteria outlined in the american academy of otolaryngology-head and neck surgery's clinical practice guideline 2. snot-22 score \>/= 20 exclusion criteria: 1. sinus surgery within 30 days of beginning the study 2. oral steroid use within two weeks of study initiation 3. active sinus exacerbation or sinus exacerbation within two weeks of starting the study 4. allergies or contraindications to fluticasone nasal spray

Keywords: chronic rhinosinusitis nasal rinses nasal irrigations
functional limitations due to the foot involvement in spondyloarthritis

Conditions: Ankylosing Spondylitis; Psoriatic Arthritis

Summary: seronegative spondyloarthritis (spa) is a group of rheumatic diseases foot involvement of the spa is common and enthesitis, erosive changes or ankylosis are the frequent lesions. the functional status of the spa patients are usually evaluated globally.the aim of this study is to assess specifically the foot -related functional limitations of the spa patients.

spa patients who had foot pain at least for 4 weeks and those having bilateral anteroposterior and lateral feet x-rays will be included into the study. foot x-rays will be evaluated by a radiologist by using the spondyloarthropathy tarsal radiographic index (spa-tri). the foot related functional status of the patients will be determined by the turkish version of the foot and ankle outcome score (faos).

Eligibility criteria:
inclusion criteria: * spa patients who had foot pain at least for 4 weeks * those having bilateral anteroposterior and lateral feet x-rays will be included into the study exclusion criteria: * patients who had flatfoot * previous foot surgery * any other disorder unrelated to the spa will be excluded

Keywords: ankylosing spondylitis psoriatic arthritis foot faos spa-tri
use of compressed sensing in breast mri

Conditions: Breast Cancer

Summary: breast mri is increasingly important in breast screening imaging. it is currently based on dynamic sequences after contrast injection whose temporal resolution must be less than 90 seconds with dynamic acquisitions at different times. these curves profiles are designed to differentiate benign from malignant lesions. recently, mann et al, (2014) showed that increasing the temporal resolution of dynamic acquisitions; lesion enhancement curves over time were more accurate than the curves usually performed. it seems necessary to work on sequences having better temporal resolution without compromising however spatial resolution.


Eligibility criteria:
inclusion criteria: * patient to benefit a mri in the assessment for a breast carcinoma * age \>18 years old * assessment on 3.0 tesla in magnetic resonance imaging * ecog performance status ≤ 3 * ability to provide an informed written consent form exclusion criteria: * age \< 18 years old * claustrophobia * contraindication to the injection of gadolinium contrast medium * contraindication to mri * persons deprived of liberty or under supervision

Keywords: algorithms image processing, computer-assisted/methods* magnetic resonance imaging/methods* data compression breast neoplasms