Kornimate/medical-research-clean huggingface dataset:
healthcare decisions post-testing, risk-reducing and preventative strategies using lynch genetic testing reducing, and preventative strategies using lynch genetic testing

Conditions: Colon Cancer; Endometrial Cancer

Summary: increase surveillance for lynch syndrome

the purpose of this minimal risk, observational survey is to increase surveillance for lynch syndrome (hereditary non-polyposis colon cancer), colorectal, and endometrial cancer, also to determine targeted risk-reducing and preventative strategies.

Eligibility criteria:
inclusion criteria: * must be a medical practitioner * medical doctor (md) * doctor of osteopathic (do) * physician assistant (pa) * advanced practice registered nurse (aprn) * nurse practitioner (np) * must have a current standard operating procedure that includes obtaining/reviewing medical history and family medical history. exclusion criteria: * government-funded insurance data cannot be included in the study.
the effect of using insoles specially designed for diabetic foot on postural balance and gait parameters

Conditions: Diabetic Foot Ulcer (DFU); Orthoses; Postural Balance; Plantar Pressure Distrubution

Summary: postural control and plantar pressure are affected by many parameters in diabetic individuals. it is considered important to examine the relationship between changes in plantar pressure distribution and postural balance, physiological expenditure index and gait parameters in diabetic individuals. within the scope of this project, based on the above mentioned reasons, we plan to produce a personalised off loading insoles designed for diabetic foot.

excessive localized loading on the plantar surface leads to repeated microtrauma and the development of diabetic foot ulcers. the plantar region, subjected to constant weight-bearing pressure, develops chronic wounds due to dangerous vascularity. excessive plantar pressure is considered the primary risk factor for plantar ulcers in diabetic individuals; custom insoles are considered the gold standard in treatment for off-loading plantar pressure. the off-loading technique, which reduces plantar pressure, is an effective ulcer prevention strategy for neuropathic feet with impaired sensation and increased plantar load and tissue stress. a review of the literature shows that previous studies have clearly demonstrated that off-loading insoles are effective in reducing abnormal plantar pressure in a specific area and that they also have some effect on the pressure distribution in surrounding areas. however, the potential impact of this positive effect on postural balance, postural control, and individuals' physiological expenditure and energy consumption has not been sufficiently studied. therefore, it is considered important to investigate the relationship between changes in plantar pressure distribution, postural balance, physiological expenditure index, and walking parameters in diabetic individuals.

Eligibility criteria:
inclusion criteria: * between the ages of 40 and 65, * wagner classification stages 0 or 1, * he has type i or type ii diabetes, * no history of amputation surgery, * individuals using shoes suitable for insoles will be included in the study. exclusion criteria: * - using an assistive device (long-walking device, walker, canadiene, etc.), * he has a history of amputation, * he has a charcot foot deformity, * the one with the open wound, * physical disability that may restrict joint movement, * individuals using shoes that are not suitable for insoles will not be included in the study.

Keywords: diabetic foot insole postural balance plantar pressure
aware registry: wearable ecg in structural heart interventions

Conditions: Atrial Septal Defect; Patent Foramen Ovale

Summary: this study is a multi-center (sinchon severance hospital / gangnam severance hospital), prospective cohort observational study to patients who had undergone structural heart intervention including device closure for secundum type atrial septal defect or patent foramen ovale. transthoracic echocardiography will be performed before the procedure, immediately after, and at 6, 18, 30 months after the procedure. wearable ecg monitoring (\> 3 days) will be performed before the procedure or immediately after procedure. demographic, laboratory, hemodynamic data during procedure, and non-invasive imaging dat are obtained.


Eligibility criteria:
inclusion criteria: * adult ≥ 19 year-old * patients who scheduled to perform percutaneous device closure for atrial septal defect or patent foramen ovale * patients provided with the written, informed consent to participate in this study exclusion criteria: * patients who had paroxysmal, persistent, or chronic af * life expectancy \< 12 months * subject who the investigator deems inappropriate to participate in this study
role of bile duct resection in major hepatectomy due to intrahepatic cholangiocarcinoma

Conditions: Intrahepatic Cholangiocarcinoma

Summary: to investigate the prognosis due to presence or absence of bile duct resection in intrahepatic cholangiocarcinoma that require hepatic lobectomy.

the bile duct resection in hepatic lobectomy due to cholangiocarcinoma, mass forming type, is still controversial. we retrospectively evaluated the effect of bile duct resection in this surgery.

Eligibility criteria:
inclusion criteria: * cases of major hepatectomy due to intrahepatic cholangiocarcinoma exclusion criteria: -
multiple ascending dose study on safety, tolerability, and pharmacokinetics of amg 581 in healthy subjects or subjects with schizophrenia or schizoaffective

Conditions: Schizophrenia or Schizoaffective Disorder

Summary: the purpose of this study is to find out the time it takes to absorb, distribute, breakdown and remove the drug from the body in healthy participants and subjects with schizophrenia and whether it causes any side effects.

the purpose of this study is to evaluate the safety, tolerability, and pharmacokinetic profile of ascending multiple oral doses of amg 581 in healthy subjects or subjects with schizophrenia or schizoaffective disorder on antipsychotic medication. the study will also assess the effects of amg 581 on midazolam pk in healthy subjects or subjects with schizophrenia or schizoaffective disorder on antipsychotic medication.

Eligibility criteria:
inclusion criteria: - provided informed consent prior to initiation of any study-specific activities/procedures; -male or female subjects should be between the ages of 18 and 45 years (18-55 years for subjects with schizophrenia);-non-nicotine or non-tobacco (healthy subjects only); - no history of relevant medical disorders; - bmi ≥ 18.0; - females of non-reproductive potential; - males practicing effective birth control; - avoid tanning/direct sunlight; - schizophrenia or schizoaffective disorder; panss score ≤ 4 points on following items (i.e. conceptual disorganization, hallucinatory behavior, excitement, suspiciousness/persecution, hostility, depression, anxiety, disorientation, uncooperativeness, disturbance of volition, and poor impulse control) / total score ≤ 80 points exclusion criteria: * females lactating/breastfeeding; pregnant partners of male subjects; essential tremor or gait disturbance; - history of hereditary shorten qt syndrome; - malignancy or tumor (other than skin cancers); - history of gi disease that could interfere with absorption; - qtc ≥ 450 msec or ≤ 380 msec; - hba1c ≥ 7%;

Keywords: schizophrenia or schizoaffective disorder
outcomes of vitrectomy combined with subtenon triamcinolone injection for the idiopathic epiretinal membrane

Conditions: Epiretinal Membrane

Summary: this study compares the anatomical and visual outcomes of patients with idiopathic epiretinal membrane(erm) treated by vitrectomy and membrane peeling with or without subtenon triamcinolone acetonide injection


Eligibility criteria:
inclusion criteria: * 1.the participant must have idiopathic epiretinal membrane 2.the participant must be willing and able to comply with the protocol. exclusion criteria: * 1. the participant has idiopathic epiretinal membrane with other ocular vascular diseases such as diabetes retinopathy, brvo, etc. 2. the participant has any additional ocular diseases that have irreversibly compromised or could likely compromise the visual acuity of the study eye including amblyopia, anterior ischemic optic neuropathy, clinically significant diabetic macular edema, severe non proliferative diabetic retinopathy, or proliferative diabetic retinopathy. 3. the participant has had intraocular surgery (including lens replacement surgery). 4. the participant has a history of (within the last six months), or current ocular or periocular infection (including any history of ocular herpes zoster or simplex).

Keywords: epiretinal membrane triamcinolone acetonide
ilm inverted flap size in macular hole

Conditions: Idiopathic Macular Hole

Summary: in the current study, the investigators described the results of a randomized, comparative clinical trial that was conducted to study the impact of the size of internal limiting membrane (ilm) inverted flap on rate and timing of idiopathic macular hole closure.

a prospective randomized comparative study included patients with idiopathic macular hole (mh) attending outpatient clinic.eligible eyes were divided into 2 groups based on the narrowest diameter of the mh measured by spectral domain optical coherence tomography (sd-oct). mhs from 250 to 400µm were classified as medium-sized mhs and mhs \> 400 µm were classified as large-sized mhs. within each group, eyes were randomly assigned to either small-flap (1-2dd) or large flap (from \>2 to 4dd).

Eligibility criteria:
inclusion criteria: * eyes with stage 4 idiopathic mhs with a diameter \>250µm on spectral domain optical coherence tomography (sd-oct) exclusion criteria: * traumatic mh * myopic mhs, * mh secondary to retinal detachment, * long-standing mh\> 12 months * previous retinal surgeries * high myopia with an axial length \> 26.0 mm * other ocular pathologies interfering with the interpretation of the oct reports.
lllt combined with cdt in breast cancer-related lymphedema

Conditions: Breast Cancer; Lymphedema

Summary: this study aims to explore the effects of low level laser therapy (lllt) on breast cancer-related lymphedema when utilized in conjunction with complex decongestive therapy (cdt) when compared to cdt treatment alone. the investigators hypothesize that the addition of lllt to cdt will result in statistically significant improvements and greater long-term benefits as measured by changes in arm volume and quality of life when compared to the benefits of cdt alone for the treatment of breast cancer-related lymphedema.


Eligibility criteria:
inclusion criteria: * unilateral breast cancer with ipsilateral lumpectomy or mastectomy and lymph node dissection (sentinel biopsy or axillary dissection) * stage ii or iii unilateral secondary upper extremity lymphedema (as defined by the international society of lymphology) * girth ≥ 2 cm circumferential difference and/or volume ≥ 200 ml compared to the uninvolved upper extremity at any 4 cm segment * able to commit to a long term follow-up schedule exclusion criteria: * active cancer/metastatic cancer * currently receiving or have plans for adjuvant radiation or chemotherapy * pregnant * presence of other extremity lymphedema (primary or secondary) * pacemaker * artificial joints in the upper quadrants * renal failure * arterial insufficiency * congestive heart failure * chronic inflammatory conditions * history of deep vein thrombosis (dvt) in the lymphedematous upper extremity * previous treatment with low level laser (regardless of indication) * medication(s) known to affect body fluid balance * body mass index (bmi) \> 40 (morbid obesity)

Keywords: lymphedema, low level laser, breast cancer
a clinical trial of the round-tunnel and flat-tunnel technique of acl reconstruction

Conditions: Anterior Cruciate Ligament Rupture

Summary: this study intends to perform round-tunnel and flat-tunnel acl reconstruction technique in 144 patients, and compare the clinical outcomes of the two surgical procedures through follow-up.

this is a prospective randomized, controlled, multi-center clinical trial study on acl reconstruction surgery technique. it is jointly undertaken by the peking university third hospital, nanjing drum tower hospital, zhengzhou orthopaedic hospital, and shenzhen second people's hospital. peking university third hospital is the team leader unit. in this study, 144 patients with acl rupture were recruited according to the enrollment criteria. among them, 54 patients with acl rupture were recruited and carried out by the peking university third hospital. the recruited patients were randomly divided into groups. the ratio of the control group is 1:1. each of the other three hospitals recruited 30 patients and randomly grouped them according to the same enrollment criteria. the ratio of the experimental group to the control group was also 1:1. in this study, 72 patients with acl rupture in the experimental group will be treated with flat-tunnel reconstruction technique, and 72 patients with acl rupture in the control group will be treated with round-tunnel technique. all operations will be performed with autologous hamstring tendons. after reconstruction, all subjects will participate in the collection of clinical function scores including tegner score, lysholm score, ikdc score, and clinical evaluation including physical examination, joint laxity, ct and mri imaging analysis to verify acl advantages of flat-tunnel technique.

Eligibility criteria:
inclusion criteria: * for the first time, the knee joint simply ruptures the anterior cruciate ligament (acl) and requires surgical reconstruction; it can be combined with meniscus injury, and the outerbridge injury score is ≤ grade ii; there is no history of trauma or fracture of the ipsilateral knee joint; posterior cruciate ligament (pcl) has no damage; medial collateral ligament (mcl) or lateral collateral ligaments (lcl) has no damage or only slight damage (no more than i degree). exclusion criteria: * bmi is less than 18.5 or greater than 35 kg/m2; patients with moderate or severe knee degeneration; those with limited flexion angle (\ grade ii.
cholecystoduodenal fistula with and without gallstone ileus

Conditions: Gallbladder Diseases

Summary: observative and descriptive study of 10 patients, which were diagnosed with a cholecystoduodenal fistula, all electronic medical records were retrospectively reviewed.

a cholecystoenteric fistula is an uncommon complication of gallstone disease, although most studies in the english literature concern biliary-enteric fistulas. the aim of this study was to present a case series of patients with a cholecystoduodenal fistula (cdf), with or without gallstone ileus, along with the surgical outcomes. from 2015 to 2018, 3245 consecutive patients underwent cholecystectomy for gallbladder disease at our institution, of whom 10 were diagnosed with a cdf. all electronic medical records were retrospectively reviewed.

Eligibility criteria:
inclusion criteria: * patients with cholecystoduodenal fistula exclusion criteria: * patients with cholecystocolonic fistula or cholecystogastric fistula

Keywords: cholecystoduodenal fistula gallbladder
psychological readiness of injured athlete to return to sport

Conditions: Athletic Injuries

Summary: clinicians are recommended to assess athletes during the rehabilitation phase to identify athletes with potentially maladaptive psychological responses to injury. therefore, the psychological readiness of injured athlete to return to sport (pria-rs) questionnaire was developed to assess the athlete's psychological readiness to return to sport. the aim of this study was to adapt the pria-rs questionnaire into turkish and to establish its validity and reliability. serial approach method will be used while translating the questionnaire into turkish. in order to evaluate the validity of pria-rs, the re-injury anxiety inventory and tampa kinesiophobia scale will be applied to the participants.


Eligibility criteria:
inclusion criteria: * athletes who have missed at least 2 months of training due to injury * having an upper, lower extremity or spine injury exclusion criteria: * having a psychological disorder * regular use of psychiatric medication

Keywords: validity reliability turkish adaptation psychological readiness sports injury
effect of heart valve replacement on cheyne-stokes respiration

Conditions: Cheyne-Stokes Respiration; Heart Valve Disease; Central Sleep Apnea

Summary: sleep disordered breathing, especially central sleep apnea, is common in patients with chronic heart failure. heart valve replacement could have some effect on central sleep apnea. the aim of the study is to investigate effect of heart valve replacement on cheyne-stokes respiration in patients with rheumatic heart disease.

sleep apnea, especially central sleep apnea, has a high prevalence in patients with chronic heart failure. although sleep disordered breathing (sdb) have been described in patients with heart disease, the prevalence is not known because: ①there are various forms of sdbs, including obstructive sleep apnea(osa), central sleep apnea (csa), and mixed forms of sleep apnea syndromes that have variable prevalence; ②patients suffering from rheumatic valve disease usually have varying degrees of heart failure, and this variability affects estimates of prevalence; ③there are no international patient registries and sdb is underdiagnosed in many parts of the world. the previous studies are most focusing on nonvalvular disease. we ①investigate the prevalence and the risk factors of cheyne-stokes respiration in patients with heart valve diseases, ②compare the changes of parameters of cheyne-stokes respiration and heart function (like apnea hypopnea index, pulse oxygen saturation, blood pressure, echocardiogram, electrocardiogram, 6-minute walk test) before heart valve replacement and 3, 6, and 12 months after the surgery. with nocturnal polysomnography (psg) examination 30 patients typical csr are going to be screened out from 300 patients with heart valve disease and waiting for cardiac surgery. the comparison of 30 patients undergoing heart valve replacement will be performed before and 3, 6, and 12 months following heart valve replacement. we shall analyze the changes of csr before and after valve replacement as well as the correlation among cardiac function and psg parameters.

Eligibility criteria:
inclusion criteria: * heart valve disease with any ejection fraction * clinical diagnosis of cheyne-stokes respiration exclusion criteria: * unstable heart failure * stroke * transient ischemic attack in last 6 months * pacemaker, cardioverter-defibrillator or resynchronization device implanted less than 6 months before study entrance * severe chronic obstructive pulmonary disease

Keywords: cheyne-stokes respiration heart valve disease central sleep apnea
angiographic characteristics of csc, pcv patients and thrombotic bio-markers

Conditions: Central Serous Chorioretinopathy; Polypoidal Choroidal Vasculopathy

Summary: thrombotic biomarkers and angiographic characteristics were compared among the de novo patients of central serous chorioretinopathy (csc), polypoidal choroidal vasculopathy (pcv) and the control.


Eligibility criteria:
inclusion criteria: * csc * neurosensory detachment in optical coherence tomography (oct) * focal leakage in fluorescein angiography (fag) and/or late choroidal hyperpermeability in indocyanine green angiography (icga) * pcv * subretinal and/or sub-retinal pigment epithelial fluid in oct * branching vascular network and/or polyps in icga * control * epiretinal membrane (erm) * without underlying systemic, ophthalmic disease other than erm exclusion criteria: * previous history of using steroid (oral, topical) * previous history of csc/pcv * previous history or evidence of intraocular inflammation including uveitis * co-existing retinal or choroidal diseases * history of allergic reaction to fluorescein or indocyanine green dye * underlying systemic conditions that could affect the thrombotic profiles (e.g. diabetes, hypertension, metabolic syndrome, coronary artery disease, cerebrovascular diseases, stroke, chronic renal failure, current smoker, pregnancy, sleep disorder)

Keywords: plasminogen activator inhibitor-1 wide angle fluorescein angiography choroid
combating hiv stigma in healthcare settings: a standardized patient approach

Conditions: Hiv

Summary: the goal of this study is to develop and evaluate the effectiveness of a training program to reduce intersectional stigma faced by sexual minorities and people living with hiv (plwh) in healthcare settings. the study participants are medical providers (i.e. physicians) specializing in sexual health medicine in china.

consistent data highlight the central role of stigma in limiting uptake of hiv related testing, treatment, and care. this is particularly true for gay, bisexual, and other msm who have the lowest rates of engagement with the healthcare system despite bearing the highest hiv incidence burden. particularly for msm seeking hiv testing services, enacted stigma-overt acts of discrimination and hostility directed at a person because of their perceived stigmatized status -both on account of their same-sex behaviors (i.e. sexuality stigma or homophobia) and the perception of their elevated hiv risk (hiv stigma) is all too common. trained standardized patients (sp) will present a standardized case to providers. sps will present clinically standardized case scenarios, but the hiv status and sexual orientation of each case will be randomly varied. stigma will be evaluated by comparing the quality of care that sps experience during provider visits. results of the baseline visit will inform the development of a stigma reduction training program for provider participants employed at clinics randomized to the treatment arm. the overall structure consists of didactic content as well as experiential learning using simulation-and-feedback sessions with trained sps.

Eligibility criteria:
inclusion criteria: eligible facilities are those with * formal government accreditation as a medical center (a basic tenet of all public hospitals in china); and * possession of an accredited on-site laboratory with capacity to provide enzyme- linked immunosorbent assay testing for hiv, treponemal (e.g. treponema pallidum particle agglutination) and non-treponemal tests (e.g. rapid plasma regain) for syphilis. within eligible and consenting facilities, eligible providers are those who are licensed at the time of the study to practice std care in china. exclusion criteria: * none
effect of chest compression on respiratory mechanics in ards patients

Conditions: ARDS, Human

Summary: in some ards patients, a mild chest compression (5 kg) improves lung compliance. we aim to determine wether such an improvement is due to a better recruitment or to a reduction of overdistension


Eligibility criteria:
inclusion criteria: * ards (berlin definition) * age \>18y * under invasive mechanical ventilation exclusion criteria: * people protected by the law