Kornimate/medical-research-clean huggingface dataset:
efficacy of a nurse telephone follow-up on pain intensity after removal of tonsils in children

Conditions: Pain

Summary: the purpose of this study is to determine if a nurse telephone follow-up to parents of children who underwent a removal of their tonsils would be effective in reducing pain intensity, complications and resort to other healthcare services

tonsillectomy in children is a common elective day surgery. in the united states, 530 000 children under 15 years of age underwent a tonsillectomy in 2006. this minor surgery generates moderate to severe pain and many postoperative complications, both in the early postoperative phase and for at least 7 days. patients are discharged home a few hours after tonsillectomy, and parents take over their child's care. but not all parents have the ability and knowledge required to adequately manage the pain and complications. this sub-optimal care situation has a significant impact on the child's convalescence and can lead to poor pain management, dehydration, poor rest and sleep quality, nausea, vomiting as well as an increase in the risk of secondary haemorrhage. many interventions have been evaluated to improve pain management, such as education strategies for parents or children and tools to guide parents. however, none of these strategies have obtained significant results on children's pain intensity post-tonsillectomy. a nurse telephone follow-up can significantly reduce pain intensity of adults who undergo ambulatory surgery. this intervention is defined as multiple telephone calls made to the patient by a nurse, after discharge, to provide information, and review discharge prescriptions and management of care by the patient himself or by a care-giver. only a few studies have explored nurse telephone follow-up for children who underwent tonsillectomy. the design of these studies, including the time-periods chosen for data collection, were not properly determined to adequately evaluate the impact of the intervention on management of pain and prevention of postoperative complications. thus, we planned to determine if a nurse telephone follow-up, made to parents following their child's tonsillectomy, would contribute to decrease pain intensity, incidence of postoperative complications and resort to other healthcare services.

Eligibility criteria:
inclusion criteria: * asa i or ii * elective surgery for tonsillectomy * parents or children able to read, and understand french or english * family equipped with a phone at home * child discharged home after the surgery exclusion criteria: * abused cases * children with a cognitive deficit * children suffering from chronic pain * child who had another surgical procedure within a month

Keywords: pediatric tonsillectomy pain management nurse follow-up
iron overload in pediatric oncology patients

Conditions: Iron Overload

Summary: the purpose of this study is to evaluate for iron overload in pediatric oncology and transplant patients who have completed their treatment between one to ten years ago.

long term survivors of childhood cancer, are a distinct group requiring specific follow-up in order to enhance their quality of life. studies have shown that many of these patients will go on to develop chronic issues within different organ systems. because of the iron burden of the frequent transfusions required to care for these patients, iron overload may indeed be one of the problems these survivors potentially face. research primarily in thalassemia and bone marrow transplant patients who were extensively transfused has shown that iron overload can have a significant impact on their overall health. complications from increased iron burden can include growth retardation, gonadal dysfunction, hypothyroidism, impaired glucose metabolism, cardiac arrhythmias and failure, hepatic fibrosis and cirrhosis, and increased susceptibility to infections. however all of these conditions related to iron overload can be prevented with the use of either phlebotomy or chelation therapy. based on this knowledge, our objective is to determine if pediatric oncology and transplant patients heavily supported with transfusions develop consequential biochemical and clinical evidence of iron overload.

Eligibility criteria:
inclusion criteria: * patients six and a half to twenty five years of age with a history of acute myelogenous leukemia, rhabdomyosarcoma, ewing sarcoma, osteosarcoma, and neuroblastoma who have completed their treatment or received their last packed red blood cell transfusion at least one year prior to enrollment (which ever occurred later) and are one to ten years post-treatment. * patients six and a half to twenty five years of age who have undergone hematopoietic stem cell transplant for any malignancy and are at least one year from their last transfusion or transplant date prior to enrollment (which ever occurred later) and are one to ten years post-transplant. * patients who were treated at schneider children's hospital or at children's hospital of philadelphia. exclusion criteria: * patients who have clinical evidence of chronic graft vs. host disease of skin, liver or gastrointestinal tract. * patients with a chronic infection (viral hepatitis), liver disease (fibrosis, cirrhosis), or a history of radiation to the liver. * patients who cannot have an mri due to metallic implants (i.e. pacemakers, prosthetic valves, etc.) * patients who are pregnant.
comparing the hemodiafiltration on-line and conventional hemodialysis in terms of cost-benefit

Conditions: Chronic Renal Failure; Hemodialysis

Summary: the site where the clinical trial will be conducted is at the st-luc hospital from the chum. this is a prospective randomized study that will compare the two treatment modalities, hd and hdf, through economics and pharmaco-economics parameters. patients, who had previously been randomized in the contrast study, will remain in their respective group and monitoring will continue. the next patients will be randomized in the same way (1: 1) using the same inclusion and exclusion criteria. hdf randomized patients will receive post-dilution standard reinjection (at least 100ml/min or 6 liter/hr). in rare cases, hdf patients can briefly have reinjection on a pre-dilution mode (if heparin need to be avoided for example) and the reinjection flow should be adjusted accordingly (200ml/min). length and frequency of sessions will be the same in the 2 groups. blood tests will not change and will be the same than those used as routine assessments. metabolic control of patients will be maintained according to the guidelines. patients will be monitored for a minimum of 3 years. a set of demographic and clinical data will be collected from patient medical records and throughout the study. biochemical data as part of the usual blood tests of dialysis patients will be collected each month as well as will be stored and analyzed information about the annual cardiac ultrasounds. all events will be scored (hospitalizations, patterns, duration) and the list and cost of drugs will be compiled every three months. these data will be useful in the economic analysis comparing the two treatment modalities.


Eligibility criteria:
inclusion criteria: * more than 18 years old, * able to consent, * patient needs to be on hemodialysis more than 8-12 hours a week (2-3 sessions) exclusion criteria: * severe none compliance (often missing sessions without good reasons), * life expectation less than 3 months, * treated with high-flux filters in the last 6 months

Keywords: hemodialysis beta microglobulin amyloidosis
multi-modal neuroimaging in children with cerebral palsy or brachial plexus birth palsy

Conditions: Cerebral Palsy; Brachial Plexus; Injury, Newborn

Summary: the main goal of this study is to identify abnormal functional and anatomical brain reorganization associated with hand, foot, and shoulder function in children (0-18 years old) with cerebral palsy (cp) due to periventricular white matter injury (pv-wmi) or brachial plexus birth palsy (bpbp) using a multi-modal neuroimaging approach.

this is a non-interventional study designed to assess changes in the sensorimotor cortex of children with cp as a result of pv-wmi and children with bpbp that combines multiple neuroimaging techniques to better visualize the resulting brain reorganization. the study design will be a mixed 3 (group: cp, bpbp, td) x 2 (hemisphere: more affected, less affected) analysis of variance (anova), with group being a between-subject factor and hemisphere a within-subjects factor. the research study plans to recruit and test 30 children with cp due to pv-wmi, 30 children with bpbp, and 30 aged-matched and typically developing (td) children aged from 0 to 18 years old. data from the participants will be collected over the course of four visits: (i) the recording session for the meg, (ii) the recording session for the eeg, (iii) the mri scanning session, and (iv) the tms session. td, cp, and bpbp subjects will be asked to commit to these visits. the meg session will last \~3 hours with the actual measurements lasting \~60 minutes, the eeg session will last \~2 hours with the actual measurements lasting \~60 minutes, the mri visit will last \~1 hour with the actual acquisition scan timing lasting \~30 minutes, and the tms visit will last \~1 and a half hours with the actual acquisition time lasting \~45 minutes. depending on the participant, the behavioral tests may be administered during any of the visits that the child is most comfortable and able to perform them.

Eligibility criteria:
inclusion criteria: children with cerebral palsy should have: * an evaluation by a pediatric neurologist with a diagnosis of cp due to pv-wmi, * absence of any genetic syndrome diagnosis, * no history of trauma or brain operation, * classified as high-functioning (i or ii) at the gross motor function classification system (gmfcs)32. children with brachial plexus birth palsy should have: * an evaluation by a hand and upper extremity surgeon with a diagnosis of bpbp * may or may not have undergone primary microsurgical or secondary reconstructive operations prior to this study. typically developing children should have: * no history of neurological disorder or brain injury. exclusion criteria: children will be excluded if they meet any of the follow criteria, determined via their medical and developmental history: * having a hard time sitting still, * presence of any metal implants, * baclofen pumps, * history of traumatic brain injury or brain operation.
nimotuzumab plus radiotherapy with concomitant and adjuvant temozolomide for cerebral glioblastoma

Conditions: Glioblastoma

Summary: this study aimed to investigate the clinical benefit contribution and safety of nimotuzumab to the standard combined treatment for patients with newly diagnosed glioblastoma.


Eligibility criteria:
inclusion criteria: * newly diagnosed, histologically proven single supratentorial gbm (who grade 4); * egfr positive; * \>50％ of the gross tumor volume removed by surgery； * karnofsky performance score (kps) ≥ 60; * adequate renal function (creatinine ≤1.5×upper limit of normal \[uln\] or creatinine clearance ≥ 60 ml/min), hepatic function (total bilirubin ≤1.5×uln and serum transaminases ≤3×uln), and hematologic function (white blood cell count ≥ 3,000/ul or absolute neutrophil count ≥ 1,500/ul, platelets ≥ 100,000/ul, and hemoglobin ≥ 10 g/dl). * tumor tissue was required for central pathology review and re-checking egfr and mgmt expression status; * an interval of 2 to 6 weeks between surgery and rt was required. exclusion criteria: * negative egfr expression; * prior chemotherapy, anti-egfr therapy, rt, or a history of malignancy in the previous 5 years; * patients with severe complications or active infection; * continuous vomiting that could interfere with the oral administration of tmz; * pregnancy

Keywords: glioma phase 2 nimotozumab temozolomide radiotherapy
impact of draining significant effusion on gas exchange and lung mechanics in patient under mechanical ventilation

Conditions: Respiration, Artificial; Pleural Effusion; Ultrasonography

Summary: patients with acute respiratory failure (arf) who were receiving mechanical ventilator support, had significant pleural effusion (both transudates and exudates) and drainage plan were evaluated. decision to drain, timing and duration of drainage were made by primary physician according to the intensive care unit (icu) protocols.the estimated amount of effusion (ml) was calculated as the maximum pleura-lung distance (mm) x 20 and significant effusion is accepted as ≥ 800 ml according to thoracic ultrasonography (usg) performed by the intensivist. the amount of effusion drained, mechanical ventilator parameters, arterial blood gas results and hemodynamic data were recorded before, at the 1st hour and at the end of drainage up to 30 days after drainage.


Eligibility criteria:
inclusion criteria: * patients on mechanical ventilation due to acute respiratory failure * estimated effusion \> 800 ml according to usg * have drainage plan according to icu protocols decided by primary physician exclusion criteria: * have absolute drainage indication (empyema, hemothorax or chylothorax) * predicted duration of mechanical ventilation less than 72 hours * contraindications to drainage, * underlying disease, which prevents lung expansion (chest deformity, central atelectasis) * malignant effusions

Keywords: pleural effusion mechanical ventilation ultrasonography drainage
prospective psychometric evaluation study of a patient-reported outcomes (pro) instrument for congenital thrombotic thrombocytopenic purpura (cttp, upshaw-schulman syndrome [uss], hereditary thrombotic thrombocytopenic purpura [http]

Conditions: Congenital Thrombotic Thrombocytopenic Purpura

Summary: the purpose of this study is to assess the psychometric properties of a recently developed congenital thrombotic thrombocytopenic purpura (cttp)-specific patient-reported outcomes (pro) instrument.


Eligibility criteria:
inclusion criteria: 1. the participant is an adolescent aged 12 to 17 years or an adult aged ≥18 years; 2. the participant has been diagnosed with congenital thrombotic thrombocytopenic purpura (cttp) and is currently receiving prophylactic or on-demand treatment with fresh frozen plasma (ffp), or solvent detergent (s/d) plasma, or von willebrand factor/factor viii (vwf/fviii) concentrates; 3. in the instance that the participant is identified and recruited remotely (direct-to-patient (dtp) recruitment), access to the internet and possession of an internet-connecting device is required; 4. the participant has provided informed consent, and in the instance that the participant is an adolescent, a legal guardian has provided informed consent and the adolescent has provided assent. exclusion criteria: 1. the participant cannot read nor write; 2. the participant is non-english speaking; 3. the participant is currently participating in a clinical trial.
advancing adolescent bedtime by mi and text reminders

Conditions: Sleep Deprivation

Summary: chronic sleep deprivation among adolescents is a prevalent health problem across the world and is associated with a series of short and long term consequences. however, effective interventions targeting on this vulnerable adolescent population is very limited. majority of the previous sleep education programme are conducted in a school context which personal factors and individualized problems were not addressed. in addition, failure to address "knowledge-action gap" may also explain why individual fail to enact health behaviors even holding positive motivation. in regard to this, investigators proposed an active and person-oriented protocol with the aid of advanced technology in order to improve adolescent sleep health.

this study will conduct a randomized control trial to evaluate the effectiveness of group-based sleep intervention using motivational interviewing plus text reminders in changing adolescent sleep deprivation problem with both subjective and objective measurements. the intervention will consists of 4 weekly group therapy targeting on adolescent with school day sleep duration less than 7 hours.

Eligibility criteria:
inclusion criteria: * chinese aged 12-18 years old * written informed consent of participation into the study is given by adolescents and his/her parents; * being able to comply with the study protocol; * having weekday sleep duration less than 7 hours for past 1 month as reported by questionnaire and average of \<7hr weekday sleep as reported by sleep diary as an indication of chronic sleep deprivation status. * possess a mobile phone exclusion criteria: * a current or past history of neuropsychiatric disorder(s); * a prominent medical condition or taking medication with potential side effects that may influence sleep quantity and quality * having a clinical sleep disorder that may potentially contribute to the disruption of sleep quantity and quality as ascertained by both structured diagnostic interview for sleep patterns and disorders such as insomnia, delayed sleep phase and narcolepsy. * have enrolled in any intervention programme that may affect their sleep patterns in the past three months or are planning to join intervention programme in the next three month

Keywords: sleep deprivation motivational interviewing text reminders
impact of postprandial 'exercise snacks' on protein and glucose metabolism following a period of step reduction in older adults

Conditions: Inactivity, Physical; Aging; Healthy Aging; Sarcopenia; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical

Summary: the purpose of this study is to assess the impact of 3-days reduced physical activity (\<1500 steps/day) with/without 'exercise snacks' (15 chair stands with calf raises every 30 min) on skeletal muscle metabolic health.

many adults gradually lose muscle size, strength, and function after the age of 50. these losses are believed to occur faster with periods of reduced activity (e.g., lower step counts or physical movement when sick or injured) and can be difficult to regain by merely returning to a previously normal activity status. such periods of reduced activity can also impair the body's ability to use the nutrients in the food consumed (e.g., proteins and carbohydrates), which increases the risk of frailty, type 2 diabetes, and ultimately a reduced quality of life. it is important to identify strategies to prevent these losses in muscle size, strength, and function especially during periods of reduced activity. recently, our laboratory has found that performing repeated bodyweight chair squats (repeated sit-to-stands with a calf raise) during a single day of reduced activity improves the muscle's ability to use carbohydrates and proteins, which may be a viable strategy to offset the negative effects of step reduction on muscle health. in this study, the investigators will assess whether completing bodyweight chair squats at regular intervals (i.e., 'exercise snacks') reduces the negative effects of step reduction on carbohydrate and protein metabolism following a meal. the investigators will determine the impact of 'exercise snacks' (15 chair stands with calf raises every 30 min) compared to seated rest on protein and carbohydrate metabolism following three days of step reduction. the investigators will also assess how these responses compare to those seen following three days of normal (i.e., habitual) activity.

Eligibility criteria:
inclusion criteria: * healthy older (age: 60-80 y) adults * bmi between normal to overweight (18.5-29.9 kg/m2) exclusion criteria: * regular use of nonsteroidal anti-inflammatory drugs (with the exception of daily low-dose aspirin) * alcohol consumption during the study period * use of anticoagulants * use of a walker, cane, or assistive walking device * current or recently remised cancer * infectious or gastrointestinal disease * inability to comply with study protocol (e.g., \>1,500 steps/day during step-reduction phase) * regular tobacco use * self-reported illicit drug use (e.g. growth hormone, testosterone, etc.) * diagnosed chronic illness (e.g. type 2 diabetes, heart disease, thyroid disease) * hormonal replacement therapy

Keywords: skeletal muscle step-reduction aging anabolic resistance physical activity stable isotopes
effect of an early mobilization program on outcomes after major cancer surgery

Conditions: Neoplasm

Summary: the aim of this study is to evaluate the effect of an early postoperative physical rehabilitation program on the functional capacity and incidence of postoperative complications in patients undergoing major elective surgery for treatment of a neoplasm


Eligibility criteria:
inclusion criteria: * patients who will be submitted to major surgery for cancer treatment. * age ≥ 18 years * reading and signing the informed consent exclusion criteria: acute myocardial infarction (within the last 30 days) * unstable angina * cardiac arrhythmia uncontrolled * symptomatic severe aortic stenosis * congestive heart failure nyha iii or iv * infarction or acute pulmonary thromboembolism * pericarditis or myocarditis * acute endocarditis * acute aortic dissection * active infection * acute renal failure * thyrotoxicosis * refusal to participate in the study * inability to ambulate independently and / or inability to exercises * presence of bone metastasis * musculoskeletal and neurological conditions that preclude the achievement of an exercise program designed for this study

Keywords: exercise neoplasm
octa analysis in children after lensectomy

Conditions: Deprivation Amblyopia

Summary: the aim of this study is to quantify and compare the foveal avascular zone (faz), the parafoveal and foveal vessel density of superficial (scp) and deep capillary plexus (dcp) and retinal thickness in deprivation amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using optical coherence tomography angiography (octa). the faz, parafoveal and foveal scp and dcp, and retinal thickness were measured in normal controls and at least 3 months postoperatively in children with unilateral cataract and compared between groups after adjusting for axial length and spherical equivalents.


Eligibility criteria:
inclusion criteria: * children after cataract surgery and healthy volunteers exclusion criteria: * presence of corneal opacity preventing detailed imaging * nystagmus * retinal disease, * persistent fetal vasculature * intraocular inflammation, * glaucoma * vitreoretinal surgery * premature birth * neurologic disease * systemic disease that could alter microvasculature (including diabetes, hypertension, cardiovascular disease and renal disease)