Kornimate/medical-research-clean huggingface dataset:
effects of delayed cord clamping during resuscitation of newborn near term and term infants

Conditions: Asphyxia Neonatorum; Resuscitation

Summary: this study evaluates resuscitation with an intact umbilical cord compared to resuscitation with the umbilical cord cut. half of the newborn babies in need of resuscitation will be handled while having an intact umbilical cord and half will have their umbilical cord cut.

the routine procedure when a newborn baby is in need of resuscitation is to cut the umbilical cord and move the baby to a designated area for resuscitation, which can include stimulation, clearing the airways, administration of oxygen and/or positive pressure ventilation by bag and mask och t-piece resuscitator. it has been suggested, and pilot studies has shown preliminary results, that keeping the umbilical cord intact while performing resuscitation may improve the babies outcome, by continued exchange of oxygen and carbon dioxide be the placenta and facilitating the neonatal pulmonary and circulatory transition. because of the limiting length of the umbilical cord, resuscitation with an intact cord must be performed in close proximity to the mother.

Eligibility criteria:
inclusion criteria: * pregnancy week ≥35 + 0 * singletons * expected vaginal delivery * the woman / couple can adequately assimilate information about the study * signed informed consent of both prospective parents exclusion criteria: * congenital malformation that complicates resuscitation (such as severe malformation of mouth, pharynx, respiratory system) or which causes the child not to be resuscitated due to internal structural malformations (such as more severe heart failure, diaphragm fractures, etc.) * the child is born via acute caesarean section after inclusion and opening of study envelope * placenta abruption / or damage to umbilical cord during childbirth (when circulation through an intact umbilical cord cannot be achieved after birth)

Keywords: umbilical cord
standard versus mnemonic counseling for fecal incontinence

Conditions: Fecal Incontinence; Counselling; Patient Satisfaction

Summary: this study compares standard versus mnemonic counseling for the treatment of fecal incontinence. a mnemonic is a word or rhyme used to aid memory. our hypothesis is that women randomised to mnemonic counseling will higher recall of treatments, satisfaction with the physician visit and greater improvement in their quality of life when compared to women who received standard counseling.


Eligibility criteria:
inclusion criteria: * over 18 years of age * diagnosed with fecal incontinence by on of the attending physicians * bothersome fecal incontinence symptoms for at least 3 months * able to give informed consent * able to speak, read and comprehend english exclusion criteria: * younger than 18 years * fecal incontinence \<3 months * unable to give informed consent * unable to speak, read and comprehend english * diagnosis of active colorectal or anal malignancy, inflammatory bowel disease, recto-vaginal fistula, and rectal prolapse

Keywords: fecal incontinence treatment options patient satisfaction
management of distal ulna fractures using hook plate

Conditions: Distal Ulna Fractures

Summary: the aim of this current prospective study is to evaluate the effectiveness of an open reduction and internal fixation {orif} by distal ulna hooked locking compression plate (lcp) in treatment of isolated displaced distal ulna fracture in adult " without concomitant distal radius fractures.

the distal ulna is an important component in the forearm and wrist motion. pronation-supination is a complex movement, combining the rotation of the radius around the ulna with a horizontal and axial translation. if the distal ulna fails to heal in the proper anatomical position maintaining its original length with significant residual angulation at the fracture site, and separation of the druj in a transverse axis, then a more severe limitation of forearm motion

Eligibility criteria:
inclusion criteria: * skeletally mature distal ulna fracture with or without radius fracture. exclusion criteria: * pathological fracture skeletally immaturity neurovascular problems
evaluation of medasense's pmd-200 during surgery and post anesthesia care

Conditions: Surgery; Nociceptive Pain; Postoperative Pain

Summary: medasense's pain monitoring device (pmd) is a novel non-invasive, bedside stand alone, continuous monitor that is designed to provide real-time information about changes in the nociception level of patients under general anesthesia during surgical procedures. the pmd-200 system is based on real-time data acquisition and processing of physiological signals. the system displays the nol index (a single numerical index) which is computed from recorded physiological parameters based on a proprietary algorithm.

the aim of this observational study is to evaluate the pattern of the nol index during surgery in the anesthetized patient and during the post-operative period in the awake patient. up to 100 patients scheduled for elective surgery under general, regional and local anesthesia and sedation, who meet all the inclusion and none of the exclusion criteria, will be enrolled after signing informed consent.

Eligibility criteria:
inclusion criteria: * both genders * age 18 - 75 years * asa physical status 1-3 * elective surgery exclusion criteria: * history of severe cardiac arrhythmia * abuse of alcohol or illicit drugs * preoperative opioid consumption for \> 1 week * history of mental retardation or any mental disease diagnosis * under sedation protocol - patients with difficult spontaneous ventilation ( for e.g. patients with sleep apnea) will be excluded.
predictive value of right atrial strain in postoperative atrial fibrillation in patients undergoing cardiac surgery

Conditions: Postoperative Atrial Fibrillation; Strains

Summary: the incidence of postoperative atrial fibrillation (poaf) after cardiac surgery is around 30%. poaf increases the risk of developing permanent atrial fibrillation and raises the risk of cardiac decompensation, stroke, acute myocardial infarction, and death. while the role of the left atrium (laf) in the pathophysiology of poaf is now well-established, the part of the right atrium (ra) remains poorly understood. recent studies suggest a correlation between ra function and poaf. ra function can be assessed by transthoracic echocardiography (tte) with dedicated software for measuring the ra strain (ras). ra function is thus divided into three phases: reservoir (rasr), conduit, and contraction. numerous studies have demonstrated that a significant alteration in ras predicts poaf in various clinical contexts. therefore, it is essential to investigate whether alterations in ra function assessed by 2d-ste (ras) are associated with an increased occurrence of fapo after cardiac surgery. it is essential to investigate whether alterations in ra function assessed by 2d-ste (ras) are associated with an increased occurrence of fapo after cardiac surgery.


Eligibility criteria:
inclusion criteria: * adult patient (\>18 years old) * the patient was hospitalized at the amiens university hospital for scheduled aortocoronary bypass grafting under cardiopulmonary bypass. * echocardiographic image quality enabling the measurement of ras parameters * patient affiliation to a social security scheme * patient/proxy information and collection of their non-opposition. exclusion criteria: * patients participating in an interventional study may modify the incidence of poaf. * history of atrial fibrillation or flutter. * valvular and ascending aorta cardiac surgery * urgent cardiac surgery. * presence of tricuspid insufficiency greater than grade 2. * left ventricular ejection fraction lower than 50%. * patient receiving circulatory mechanical assistance before surgery. * dependency on ventricular and atrial pacing by an internal or external cardiac pacemaker during the echocardiographic examination.

Keywords: coronary bypass grafting postoperative atrial fibrillation strain left atrial right atrial
effect of photodymamic therapy with urucum and led in the reduction of halitosis

Conditions: Halitosis

Summary: halitosis, also known as bad breath, is a term used to define an unpleasant and foul odor that emanates from the mouth and may have local or systemic origin. this project aims to observe the presence of halitosis and to verify if the treatment with antimicrobial photodynamic therapy (apdt) is effective against it. the investigators will select 45 students or uninove employees, from 18 to 25 years old, with a diagnosis of halitosis, presenting sulfite (sh2) ≥ 112 ppb on gas chromatography. patients will be randomly divided into 3 groups of 15, which will receive different treatments: group 1: treatment with tongue scraper; group 2: apdt applied in the back region and middle third of the tongue; group 3: combined treatment of tongue scraper and apdt. for the apdt we will use urucum manipulated in the concentration of 20% (fórmula e ação®) in spray, to be applied in sufficient quantity to cover the middle third and back of the tongue (5 sprinkles) for 5 minutes for incubation, associated with a led (valo cordless ultradent®). 6 points will be irradiated on the back of the tongue with a distance of 1 cm between the points, considering the halo of light scattering and effectiveness of apdt. the apparatus shall be precalibrated at wavelength 440-480nm for 60 seconds per point, irradiance of 450mw/cm and the light shall be irradiated so that a halo of 2cm diameter is formed per point. the results of the halimetry will be compared before and immediately after the treatment, besides the microbiological analysis of the tongue coating, before and after the treatment. the normality of the data will be measured using the shapiro-wilk test, and in the case of normality the variance analysis (anova) test will be applied, and in the case of non-parametric data, the kruskal-wallis test will be used. to analyze the results of each treatment in both periods of the study, the wilcoxon test will be used.


Eligibility criteria:
inclusion criteria: * age between 18 and 25 years; * sulphide (sh2) ≥ 112 ppb in the gas chromatography. exclusion criteria: * dentofacial anomalies (such as cleft lip and cleft palate); * undergoing orthodontic and/or orthopedic treatment; * undergoing oncological treatment; * systemic alterations (gastrointestinal, renal, hepatic); * treatment with antibiotics up to 1 month before the survey; * pregnant.
droperidol on prevention of cannabis hyperemesis syndrome

Conditions: Cannabis Hyperemesis Syndrome

Summary: the purpose of this study is to assess the efficacy of droperidol as a treatment of cannabinoid hyperemesis syndrome.

patients presenting to the emergency department with nausea, vomiting and/or abdominal pain with a significant history of cannabis use and symptoms in a cyclic pattern will be assessed for study inclusion. after given written informed consent, patients will be treated with droperidol and diphenhydramine and symptoms will be assessed using a visual analog scale at time intervals up to 120 minutes. patient will then be contacted at 24 and 48 hour intervals to assess symptoms on the same scale. this is a multicenter, prospective interventional study with results compared to a historical cohort using haloperidol.

Eligibility criteria:
inclusion criteria: * aged 18 years of age or older and presenting with cannabis hyperemesis syndrome requiring intravenous medication. exclusion criteria: * any patient with a contraindication to the use of droperidol * corrected qt interval on ecg greater than 440 milliseconds for males and greater than 450 milliseconds for females * any prisoners * pregnant females.
using text messages to boost covid-19 vaccine booking rate

Conditions: Vaccination Hesitancy; COVID-19

Summary: this study is a nationwide randomised controlled trial (rct) to test the impact of behavioural science-informed text messages notifying patients of their eligibility for the covid-19 vaccine on vaccination rates.


Eligibility criteria:
inclusion criteria: * (i) satisfying the age criteria as defined above; * (ii) recorded in the national immunisation management system (nims); * (iii) with a valid mobile phone number; * (iv) who had not already received or been invited for the covid-19 vaccine via nims at the time of the study. exclusion criteria: * participants with invalid phone numbers
the effect of protein on calcium absorption and gastric acid production

Conditions: Osteoporosis

Summary: we have established that dietary protein is an important regulator of intestinal calcium absorption in humans. however, we do not understand the mechanism by which dietary protein is affecting calcium absorption. therefore, the purpose of this research is to evaluate whether dietary protein-induced changes in gastric acid secretion explain the observed changes in intestinal calcium absorption.

we have established that dietary protein is an important regulator of intestinal calcium absorption in humans. however, we do not understand the mechanism by which dietary protein is affecting calcium absorption. therefore, the purpose of this research is to evaluate whether dietary protein-induced changes in gastric acid secretion explain the observed changes in intestinal calcium absorption. we have compelling in vitro data that amino acids can stimulate gastric acid secretion. we have found that this occurs via allosteric activation of the calcium sensing receptor expressed on the gastric acid-secreting parietal cells. at a fixed concentration of extracellular calcium, addition of l but not d isomers of specific amino acids activates the calcium sensing receptor and stimulates parietal cell acid production. we hypothesize that dietary protein induced gastric acid production increases calcium solubility and bioavailability thereby increasing its absorption. we will test this hypothesis in humans by quantifying the impact of dietary protein on intestinal calcium absorption in subjects who cannot make gastric acid. we will measure intestinal calcium absorption in healthy adults as they consume either a high protein diet with concomitant administration of a proton pump inhibiting (ppi) drug or the same high protein diet with a placebo instead of a ppi. the order of the 2 interventions will be randomized, and study will be double-blind and placebo controlled. if our hypothesis is correct, then intestinal calcium absorption will be highest during the high protein diet with placebo, and lowest during the drug intervention.

Eligibility criteria:
inclusion criteria: * healthy men and women age 18-45 years * caucasian or asian descent due to increased risk of osteoporosis exclusion criteria: * gastrointestinal diseases * osteoporosis * diabetes * hypertension * liver disease * thyroid disorders * kidney disease * kidney stones * cancer * heart disease * eating disorders * obesity * hypogonadism * amenorrhea * oligomenorrhea * abnormal serum fsh or estradiol levels * birth control medication or other hormone-altering medications * pregnancy * lifestyle factors such as: * smoking * excessive exercise (although moderate exercise is allowed) * prescription medications known to influence vitamin d or calcium metabolism or gastric acid * excessive body weight change during the past 6 months * food allergies * unusual eating habits or medically prescribed diets

Keywords: gastric acid dietary protein calcium intestinal absorption calcium sensing receptor
improvement in clinical outcomes in heart failure patients with icds that practice meditation

Conditions: Congestive Heart Failure; Cardiac Resynchronization Therapy

Summary: this is a trial to examine the effects of meditation on the incidence of ventricular arrhythmias and the psychological profiles in patients with implanted cardiac defibrillators. we wish to test the following hypotheses: 1. vipassana meditation reduces the incidence of atrial and ventricular arrhythmias in patients with congestive heart failure. 2. vipassana meditation improves the psychological profile in patients with chf. in this study, subjects meeting the inclusion and exclusion criteria will be recruited into the study after obtaining informed consent. the subjects will then be randomized into either an experimental group ( meditation) or into a control group (usual care).

this is a single center, investigator-initiated, randomized, controlled trial to examine the effects of meditation on the incidence of ventricular arrhythmias and the psychological profiles in patients with implanted cardiac defibrillators and cardiac resynchronization devices. the former are used to protect patients against cardiac fibrillation and the latter for synchronizing the contractions of the two ventricles.

Eligibility criteria:
inclusion criteria: * men and women aged 18 to 85 * all patients with nyha class ii to iii congestive heart failure symptoms from ischemic and non-ischemic etiology who received a defibrillator at least 3 months prior to enrollment. * all patients with nyha class iii and iv symptoms, qrs complex of the ecg more than 120 ms, who received device for cardiac resynchronization at least 3 months prior to enrollment. these devices are placed when the two ventricles beat at slightly different times. these devices also have the capacity to record arrhythmias as the defibrillators. exclusion criteria: * patients with life expectancy less than 6 months from non-cardiac causes * pregnant women * smokers * history of major psychosis. * significant chronic liver, renal and pulmonary disease * active alcohol and drug abuse

Keywords: meditation congestive heart failure icd cardiac resynchronization therapy
investigation of genetic marker associated with obesity in koreans

Conditions: Obesity

Summary: a single-nucleotide polymorphism (snp) analysis of dna obtained from peripheral blood of the obese patients and the normal control will be performed to find genetic marker for obesity


Eligibility criteria:
inclusion criteria: * bmi 25\~30kg/m2 exclusion criteria: * all were nonsmokers and had no evidence of cancer, liver, renal, hematological disease or other metabolic disorders other than obesity
the impact of higher positive end expiratory pressure on patient-ventilator asynchrony

Conditions: Critical Illness

Summary: patient-ventilator asynchrony is known to frequently occur during lung protective ventilation in patients with ards. previous clinical studies showed that patient-ventilator asynchrony was associated with worse outcome in icu. therefore, strategies to reduce patient-ventilator asynchrony need to be established promptly. several asynchronies, e.g., breath stacking are caused by vigorous spontaneous breathing effort. recently, the investigators' group found that higher positive end expiratory pressure (peep) reduced the intensity of spontaneous breathing effort of in severe ards model (rabbits, pigs) and patients with ards. thus, the investigators conjectured that higher peep may reduce the intensity of spontaneous breathing effort and thereby reduce patient-ventilator asynchrony during protective ventilation strategy, compared with lower peep in patients with ards.

the cross-over study will enroll 10 participants fulfilled with the criteria of berlin definition of moderate-to-severe ards and under mechanical ventilation in intensive care unit (icu) at osaka university hospital. informed consent will be obtained by legal representatives. after obtaining informed consent, participants will be randomly assigned to one of two groups: "higher peep - lower peep" or "lower peep - higher peep". peep, either higher or lower, will be set according to higher or lower peep/fio2 table. the depth of sedation will be monitored quantitively and maintained to be the same throughout the protocol. the intensity of spontaneous breathing activity will be assessed with esophageal balloon manometry and electrical activity of diaphragm. at each peep setting, asynchrony index will be calculated.

Eligibility criteria:
inclusion criteria: 1. patients ≧ 18 years old 2. patients with moderate to severe ards under mechanical ventilation＊ ＊ definition of moderate to severe ards is as per the berlin definition (pao2/fio2 ≦ 200 mmhg with peep ≧ 5 cmh2o) exclusion criteria: 1. lack of informed consent 2. continuous neuromuscular blockade at enrollment 3. dnr (do-not-resuscitate) 4. moribund patient not expected to survive 24 hours 5. massive hemoptysis 6. increased intracranial pressure (\> 18 mmhg) 7. existence or high risk of pneumothorax 8. known pregnancy 9. actual body weight exceeding 1 kg/cm 10. patient judged to be inappropriate for the trial by intensivist

Keywords: patient ventilator asynchrony positive end expiratory pressure
characteristics of hgb c carriers in northern israel and clinical features among hgb homozygous

Conditions: Hgb C Hemoglobinopathy

Summary: hgb c is an hemoglobinopathy quite rare in israel. the clinical status of patients that are diagnosed as homozygous to this disease is quite benign but not study in large groups. also the characteristics of carriers and the incidence in northern israel were a large arab population lives, was not study. the results of this study can be useful for screening purpose in a area were another hemoglobinopathies are frequent.

hgb c is an hemoglobinopathy quite rare in israel. the clinical status of patients that are diagnosed as homozygous to this disease is quite benign but not study in large groups. also the characteristics of carriers and the incidence in northern israel were a large arab population lives, was not study. the results of this study can be useful for screening purpose in a area were another hemoglobinopathies are frequent. the study will record the clinical characteristics of the homozygous hgb c patients and the hematology characteristics of all the heterozygous carriers detected in northern israel

Eligibility criteria:
inclusion criteria: * all patients diagnosed as homozygous for hgb c disease or double heterozygous in combination to other abnormal hemoglobin, and all the carriers detected in the hematology laboratory during the screening for abnormal hemoglobins in northern israel

Keywords: hgb c screening