Kornimate/medical-research-clean huggingface dataset:
a study to evaluate the efficacy and safety of ertugliflozin in participants with type 2 diabetes mellitus and inadequate glycemic control on metformin monotherapy (mk-8835-007).

Conditions: Type 2 Diabetes Mellitus

Summary: this is an efficacy and safety study of ertugliflozin in participants with type 2 diabetes mellitus (t2dm) and inadequate glycemic control on metformin monotherapy. the primary study hypothesis is that at week 26, the mean reduction from baseline in hemoglobin a1c (hba1c) for ertugliflozin is greater than that for placebo.

the trial includes a 13-15 week run-in period prior to randomization, and a 26-week, double-blind, placebo-controlled treatment period followed by a 78-week double-blind, extension period.

Eligibility criteria:
inclusion criteria: * diagnosis of t2dm in accordance to american diabetes association guidelines * participants must be receiving metformin monotherapy for less than 8 weeks prior to study participation or require change in their diabetes regimen to remain eligible to participate in the trial (including discontinuing anti-hyperglycemic agent \[aha\] therapy) and must have a hemoglobin a1c of 7.0 to 10.5% (53-91 mmol/mol) after at least 8 weeks on a regimen of metformin monotherapy exclusion criteria: * history of myocardial infarction, unstable angina, arterial revascularization, stroke, transient ischemic attack, or new york heart association (nyha) functional class iii-iv heart failure within 3 months of study participation * a clinically significant electrocardiogram abnormality * a history of malignancy ≤5 years prior to study participation, except for adequately treated basal or squamous cell skin cancer or in situ cervical cancer * a known hypersensitivity or intolerance to any sodium-glucose co-transporter 2 (sglt2) inhibitor or glimepiride * on a blood pressure or lipid altering medication that have not been on a stable dose for at least 4 weeks prior to study participation * a surgical procedure within 6 weeks prior to study participation or planned major surgery during the trial * donation of blood or blood products within 6 weeks of study participation or plans to donate blood or blood products at any time during the trial * pregnant or breast-feeding, or is expecting to conceive during the trial, including 14 days following the last dose of study drug
stroke triage optimization by ambulance paramedics in the pre-hospital setting

Conditions: Stroke, Acute; Pre-hospital Triage; Stroke Treatment; Stroke Code

Summary: there are everal scales designed to help ambulance paramedics to identify a patient with a stroke and activate a stroke code. these scales were never tested in the field in a large unselected patient sample. we aim to perform an in-the field head tot head comparison of all published stroke scales designed to be used by ambulance paramedics

this is a multicenter multiregional cohort study including about 3000 stroke code patients. in all patients an application will be filled out before hospital arrival including items that enable us to reconstruct all previously published stroke scales. data from the application will be related to in hospital data of the same patient. in order to do this we will use a trusted third party for data coupling.

Eligibility criteria:
inclusion criteria: * patients for whom a stroke code is activated exclusion criteria: \< 18 years
blood ddpcr for early identification and dynamic surveillance of pathogenic bacteria in icu septic patients: a single-centre, prospective, observational study

Conditions: Sepsis; Bloodstream Infections; Critically Ill Intensive Care Unit Patients

Summary: the purpose of this study is to investigate the efficacy of droplet digital pcr (ddpcr) in identifying pathogenic organisms in icu sepsis patients, aiming to find a method that allows early identification of pathogenic organisms and dynamic surveillance in order to assess the association between pathogenic species and loads and clinical characteristics and outcomes.

this is a monocentric observational study. patients admitted to the icu with a first diagnosis of sepsis will be dynamically monitored for nucleic acid loads of pathogenic bacteria in the blood using ddpcr at different time points until the last blood sample is taken on day 28-30 or the patient is discharged from the icu.

Eligibility criteria:
inclusion criteria: * patients with first diagnosis of sepsis after icu admission exclusion criteria: * age under 18 years * do not meet sepsis 3.0 diagnostic criteria * refusal to sign informed consent

Keywords: ddpcr sepsis icu
fluoride delivery to prevent white spots during orthodontic treatment

Conditions: Orthodontic Appliance Complication; Tooth Demineralization

Summary: the aim of this 2-armed, parallel, randomised, controlled trial is to assess the effect of different ways of applying fluoride to teeth on the formation of white spots (enamel demineralisation), during orthodontic treatment with fixed metal braces, in children and adolescents.

one of the most common side-effects and risks of orthodontic treatment with fixed (metal) braces is damage to the outer surface (enamel) of the teeth. this damage can take the form of white or brown spots on the teeth (white spot lesions; wsls) or if severe, holes in the teeth that need a filling. the aims of this study are to find out the best way of preventing damage to the teeth of children and adolescents who are under going orthodontic treatment with fixed (metal) braces. the participants will be 130 children, aged 11-16 years old, inclusive. the participants will be split into two groups using a process called randomisation. the treatments will be standard fluoride toothpaste (colgate) and either: 1. fluoride mouth wash (fluorigard) or 2. tooth mousse plus the participants' teeth will be checked at every visit and the brace adjusted. photographs of the participants' teeth will be taken very 3 months to see if any of the teeth have been damaged. the participants will be asked about the impact of their teeth on their life. participants and parents will be asked about the impact of any white spots that form on the participants' teeth during the treatment with fixed (metal) braces. the study will follow the participants through the whole length of treatment which will take about 2 years.

Eligibility criteria:
inclusion criteria: * planned to receive orthodontic treatment with upper and lower fixed orthodontic appliances (braces) either alone or following a period of functional appliance treatment. * 11-16 years of age inclusive at the start of the fixed orthodontic appliance treatment. * all genders. * fit and well with no chronic disease necessitating regular hospital follow-up at hospital. * willing to participate exclusion criteria: * significant disabilities that may affect manual dexterity; * any medical complication that would contraindicate the use of the fluoride treatments or milk products; * previous orthodontic treatment except phase i functional appliance treatment; * from areas that have fluoridated water supply\*; * full coronal coverage restorations; * more than 2 missing anterior teeth; * showing signs of systemic illness e.g. fever, cough, loss of taste/smell; * any abnormality of face, lips e.g. cleft lip and/or palate or craniofacial abnormality or soft tissues of the mouth e.g. aphthous ulcers or connective tissue disorder.

Keywords: fluoride cpp-acp
evaluation of clinical decisions and assessment of those at risk of primary angle closure by community optometrists

Conditions: Angle Closure Glaucoma

Summary: increases in the aging population has resulted in increased demand for glaucoma services. glaucoma is a disease that if untreated, can lead to blindness. this increase and need for long term treatment with monitoring have resulted in a significant demand in the hospital eye service (hes). many departments are now facing a considerable backlog of outpatient appointments and it's essential that these appointments are reserved for patients who are at risk of glaucoma blindness. primary angle closure (pac) glaucoma is a type of glaucoma, where the drainage route for the fluid inside the eye (known as the angle) is narrowed or blocked. it has been recently identified that approximately half of patients referred into the hes for a suspect narrow angle for further investigation are healthy and are immediately discharged. the exact reasons for these findings are unknown. this project will investigate clinical decisions by community optometrists who account for the majority of pac referrals into the hes, as well as assessing their ability to evaluate those at risk of pac. this project will also examine whether clinical agreement could be improved by providing an educational package. a clinical image database of angles will be acquired from glaucoma patients attending moorfields eye hospital. a learning package discussing angle closure referral will also be developed. community optometrists will be invited to complete a questionnaire on their clinical decision making. this will be followed by the vignette assessment, learning package and re-assessment. if this educational package and/or any other identifiers are found to improve agreement levels, this could reduce the number of referrals and enable community monitoring of those at low risk of developing pac glaucoma in their lifetime.


Eligibility criteria:
inclusion criteria: new patients attending the glaucoma clinic at moorfields eye hospital exclusion criteria: * they cannot be examined using a table mounted slit lamp due to physical limitations or have gross nystagmus. * unable to consent * if they are unable to communicate in english and there is no available interpreter that meets requirements set out by moorfields standard operating policies for patients * under 18 years old

Keywords: limbal anterior chamber depth optometrist angle-closure van herick
remote monitoring use in cases of suspected covid-19 (coronavirus)

Conditions: Coronavirus

Summary: the study aims to see if participant deterioration due to suspected coronavirus in a designated location (e.g. hotel) can be identified sooner by wearing the sensor. if sick patients can be identified early, participants are more likely to have better outcomes; the study believes that the sensor can help us do this. the sensor measures heart rate, respiratory rate and temperature every 2 minutes and this can be reviewed by the clinical team looking after the participants.


Eligibility criteria:
inclusion criteria: * aged 18 years or over. * able to provide written consent. exclusion criteria: * any participants that withdraw their consent. * a skin condition/reaction preventing wearing the wearable sensor. * the presence of a permanent pacemaker or cardiac defibrillator. * any form of psychiatric disorder or a condition that, in the opinion of the investigator, may hinder communication with the research team. * inability to cooperate or communicate with the research team.

Keywords: coronavirus remote monitoring deterioration escalation
virtual reality effect in geriatric individuals

Conditions: Pain; Depression

Summary: this study aimed to determine the effect of a virtual reality experience on pain, depression and functional adequacy in geriatric individuals living in a nursing home. a virtual reality video with dance moves has been applied to the experimental group participants. each video takes 3 minutes, and the elderly person has been put into practice at least 30 minutes after having breakfast in 3-minute periods and at least 30 minutes after dinner. in the morning and evening, 15 minutes, 2 times a day, a total of 9 days were applied for 3 weeks. the application lasted a total of 3 weeks. scales were applied 1 week after the virtual reality application was completed and 1 month after the experimental group. the scales were filled in the control group at the same time.

it is recommended that the future studies be conducted with larger samples on pain, depression, life quality and functionality.

Eligibility criteria:
inclusion criteria: * suffering from musculoskeletal pain in the last 3 years, * being energetic (being independent in the daily life activities), * being able to stand up without help before 30 seconds and walk at least six meters without help, * individuals with blood sugar ranging between 90-200 mg/dl prior to the application, * individuals with blood pressure ranging between 130-70 mm/hg prior to the application, * not having neurological and psychiatric diseases, * no history of fall, * being literate, * not being visually-hearing impaired, * being able to communicate verbally. exclusion criteria: * pependent patients * patients with psychiatric illness * patients with joint pain disease diagnosis

Keywords: geriatric pain geriatric depression
clinical evaluation of teeth prepared with vertical preparation versus deep chamfer

Conditions: Single Posterior Crowns; Endodontically Treated Teeth; Decayed Teeth

Summary: it has been demonstrated that a great amount of tooth structure is lost during the prosthetic preparations of abutments for full-coverage fdps with tooth substance removal of 63% of 73%, this aggressive loss of tooth structure usually accompanied with pain and post-operative sensitivity. in comparison with the vertical preparation technique, there is less amount of tooth substance loss. this clinical study will provide benefits for practitioners and clinicians by guiding them to choose a more conservative treatment plan with the better marginal fit, clinical performance and satisfaction for the patients on the long term. rather than other benefits like less chair time, less risk for pulp injury, less time and cost

a healthy relationship between dental restorations and the periodontium is of prime importance for the clinical longevity and esthetic harmony of full coverage restorations . one of the most common complications, derived from fixed prostheses is gingival recession, which constitutes an important clinical concern. this problem is largely associated with iatrogenic effects produced during dental preparation or as a result of poor prosthetic fit which can cause chronic inflammation leading to gingival margin recession around the restoration .

Eligibility criteria:
inclusion criteria: 1. the patients in this study will be in the range of 18-50 years 2. have no active periodontal or pulpal diseases, have teeth with good restorations 3. psychologically and physically able to withstand conventional dental procedures 4. able to return for follow-up examinations and evaluation 5. no tooth mobility or grade 1 can be accepted 6. patients with teeth problems indicated for single posterior crowns: 1. badly decayed teeth 2. teeth restored with large filling restorations 3. endodontically treated teeth 4. malformed teeth 5. malposed teeth (tilted, over-erupted, rotated, etc.) 6. spacing between posterior teeth exclusion criteria: 1. patients under the age of 18 or being incapable of taking out a contract 2. patient with active resistant periodontal diseases 3. patients with any medical condition that impaired correct oral hygiene 4. a conspicuous medical or psychological history 5. bruxism, or known allergic reaction to the materials used. 6. pregnant female patients
rescue study - everolimus in liver transplantation recipients with renal insufficiency

Conditions: Liver Transplantation

Summary: the purpose of the study is to assess the effect of everolimus initiation together with reduction or discontinuation of calcineurin inhibitor (cni) on renal function in maintenance liver transplant recipients with cni-related renal impairment, while maintaining efficacy.


Eligibility criteria:
inclusion criteria * male or female 18 - 70 years old * patient who has undergone a primary liver transplantation 12 to 60 months ago from a cadaveric or a living donor * patient with a calculated gfr ≤ 60 and ≥ 20ml/min * patient receiving tacrolimus with c0-h level ≥ 3 and ≤ 8 ng/ml or neoral® with c0-h level ≥ 50 and ≤ 150 ng/ml or with c2-h level ≥ 250 ng/ml and ≤ 650 ng/ml with or without any of the following (mpa or aza or steroids) * patient willing and capable of giving written informed consent for study participation and able to participate in the study for 6 months * patient in whom an allograft biopsy will not be contraindicated * female capable of becoming pregnant must have a negative pregnancy test prior to randomization and are required to practice a medically approved method of birth control for the duration of the study exclusion criteria * recipient of multiple solid organ transplants * patient on dialysis * patient with an identifiable cause of renal dysfunction other than cni toxicity * patient with proteinuria ≥ 1.0 g/24h * patient with any acute rejection within 6 months prior to randomization * patient with platelet count of ≤ 50,000/mm³ or white blood cell count of ≤ 2,000/mm³ or hemoglobin value ≤ 8 g/dl * undergone a liver transplantation for a hepatocellular carcinoma with sign of recurrence; * severe graft dysfunction; * hcv positive patient who needs an active anti-viral treatment * hiv positive patient * patient who is breast feeding * patient with a current severe systemic infection * patient who has received an unlicensed drug or therapy within one month prior to study entry * presence of any hypersensitivity to drugs similar to everolimus (e.g. macrolides) * use of any other immunosuppressive drugs than tacrolimus/cyclosporine microemulsion, steroids, azathioprine and mycophenolic acid additional protocol-defined inclusion/exclusion criteria may apply.

Keywords: liver transplantation, everolimus, calcineurin inhibitor, renal function
ambulation as a factor on oscillating thermometry

Conditions: Diabetic Neuropathy Peripheral

Summary: this research study aims to better understand how the plantar temperature data collected by the podimetrics rtm system corresponds to physical activity level in subjects.

subjects with prescription for monitoring with podimetrics rtm system will be assigned activity monitors to track physical activity. data from the podimetrics rtm system and the activity monitor will be assessed after one month of use to determine any correlation between the two data sets and adherence to the use of activity monitor.

Eligibility criteria:
inclusion criteria: study subjects must * be at least 18 years old * not be pregnant * provide informed consent * have a prescription for monitoring with podimetrics remote temperature monitoring system exclusion criteria: * be younger than 18 years old * unable to understand english * unable to provide consent * at the discretion of the investigator
efficacy and influence of pilates based physical therapy exercises for low back pain

Conditions: Mechanical Low Back Pain

Summary: an assessment of the effectiveness of pilates based physical therapy exercises for patients with low back pain (lbp) and its influence on spinal movement and patient reported functional disability.

low back pain (lbp) is becoming a major public health problem associated with enormous economic burden on the modern society. despite conservative interventions such as pilates back exercises are routinely prescribed in clinical practice, most studies to date have only assessed its efficacy based on subjective patient reported outcomes with limited objective data available to clearly demonstrate the benefit of pilates exercise on spinal alignment and mobility. furthermore, patient adherence has been well identified to be an obstacle for effective home exercise program and the most cost-effective strategy to improve patient compliance remain unknown. current study therefore aims to fulfil this gap in our knowledge by assessing the change of spinal alignment and kinematics utilizing dynamic radiographs performed pre- and post- a 6-week pilates based physical therapy exercise program compare to a more generic hospital based back care exercise program. furthermore, the effectiveness of conducing weekly phone reminders for 6 weeks on improving short (6-month) and long (12-month) term functional outcomes and patient compliance will also be assessed.

Eligibility criteria:
inclusion criteria: 1. predominant lbp for a minimum of three consecutive months as diagnosed by a rehabilitation physician exclusion criteria: 1. . radicular neurological signs, 2. . trauma induced lbp, 3. . diagnosis of spinal deformity such as scoliosis or spondylolisthesis, 4. . spinal infection or tumor, 5. . rheumatologic conditions, 6. . previous spinal surgery, 7. . history of hip or pelvic disorder that required treatment, 8. . contradiction for radiographic exposure such as pregnancy.

Keywords: spinal alignment kinematics pilates physical therapy
effects of elavl and cdoa vs upper thoracic mobilization on forward head posture in upper cross syndrome

Conditions: Cross Syndrome

Summary: this randomized controlled study will examine the patient of forward head posture who suffering with upper cross syndrome. there will be comparison of two treatment methods 1st one is elongation longitudinaux articular vertebral and columnar decoaption osteo-articulaire also known as eldoa and 2nd is upper thoracic mobilization .

this study includes 42 participants, both male and female, age between 20 to 45. eldoa target the cervical and upper thoracic spine to improve range of motion, restore normal cervical and thoracic spine alignment and reduce muscle tension. upper thoracic mobilization improve thoracic spine mobility and enhance cervical spine alignment.

Eligibility criteria:
inclusion criteria: * adult between (20 to 45 year) with upper cross syndrome * cva angle less than 48-50 degrees. * no history of spinal injury and fracture * limited cervical range of motion exclusion criteria: * severe spinal degeneration or deformity * injury or surgery * cervical radiculopathy * severe osteoporosis * malignancy of upper extremity of thorax * obesity
microvolt t-wave alternans in cardiac surgery patients

Conditions: Postoperative Complications; Electrocardiogram: Electrical Alternans

Summary: the purpose of this study is to measure mtwa in the patients undergoing cardiac surgery and to investigate the relation between mtwa and adverse clinical outcomes.


Eligibility criteria:
inclusion criteria: * all patients underwent cardiac surgery including coronary artery bypass graft surgery with or without cardiopulmonary bypass, cardiac valve surgery, cardiac mass excision, thoracic aorta surgery, etc. exclusion criteria: * unavailability of the recording equipment
evaluation of tp us in women with prolapse

Conditions: Prolapse

Summary: many women suffers from uterine and vaginal prolapse usually they suffer from these symotoms in menopause

the most common cause of pelvic organ prolapse is multiple pregnancy and multiparity

Eligibility criteria:
inclusion criteria: * women with history of normal delivery age between 25 to 75 years exclusion criteria: * women with cesarean deliveries