Kornimate/medical-research-clean huggingface dataset:
safety and tolerability of nnc0114-0006 at increasing dose levels in subjects with rheumatoid arthritis

Conditions: Inflammation; Rheumatoid Arthritis

Summary: this trial is conducted in europe. the aim of this dose-escalating trial is to assess the safety and tolerability of multiple doses of nnc0114-0006 in subjects with rheumatoid arthritis (ra).


Eligibility criteria:
inclusion criteria: * a diagnosis of ra, meeting the 2010 acr-eular (american college of rheumatology-european league against rheumatism) or the 1987 acr classification criteria, made at least 4 months prior to trial drug administration * active ra, characterised by a das28-crp equal to or above 4.5 and at least 5 tender and 5 swollen joints * methotrexate (mtx) treatment for at least 16 weeks (dose equal to or above 7.5 mg/week and equal to or below 25 mg/week) at a stable dose for at least 6 weeks prior to dosing * female subjects not pregnant and not nursing exclusion criteria: * subjects with chronic inflammatory autoimmune disease other than ra * any active or ongoing chronic infectious disease requiring systemic anti-infectious treatment within 4 weeks prior to randomisation * body mass index (bmi) below 18.0 or above 35.0 kg/m\^2
nebulized midazolam, dexmedetomidine, and their combination in sedation of preschoolers undergoing dental treatment

Conditions: Dental Anxiety

Summary: the aim of the study is to evaluate the effect of nebulized midazolam, dexmedetomidine, and their combination as procedural, moderate sedative agents in preschoolers undergoing dental treatment.

dental anxiety and fear related behaviors are global problems in pediatric dentistry. preschoolers represent a dental behavior management problem and there is always a debate over the best behavioral management technique for preschoolers undergoing dental treatment. moderate sedation is considered as an acceptable option. children who need treatment under local anesthesia, for thirty minutes will be included in the study. a total of 72 uncooperative pediatric dental patients, of age range 4-6 years, will be selected from the pediatric dentistry and dental public health department, faculty of dentistry, alexandria university, egypt. the participants will be randomly allocated into 3 groups that will undergo a procedural sedation session via a nebulizer. children of group i will receive nebulized solution of 0.5 mg/kg midazolam, group ii will receive nebulized solution of 5µg/kg dexmedetomidine, and group iii will receive a nebulized solution of 0.3 mg/kg midazolam and 3µg/kg dexmedetomidine respectively.

Eligibility criteria:
inclusion criteria: * age range 4-6 years * frankl scale score 2. * asa i or ii physical status. * dental intervention under local anesthesia not requiring more than 30 minutes. * no previous dental experience. * parent/guardian"s written consent. exclusion criteria: * dental treatment indicated under general anesthesia. * presence of facial deformities. * history of neurological or cognitive alterations. * mouth breathers.

Keywords: nebulized dexmedetomidine nebulized midazolam moderate sedation dental procedural sedation pediatric dentistry
the effect of behavioral therapy given to men and their partners'

Conditions: Premature Ejaculation; Sexual Function Disturbances

Summary: premature ejaculation involves not only sexual problems but also relationship and communication difficulties, and behavioral approaches to the treatment of premature ejaculation are promising.

introduction and hypothesis: premature ejaculation potentially affects not only men but also their partners negatively. the null hypothesis for this study is behavioral therapy given to men with premature ejaculation has no effect on the symptoms and their partners' sexual functions and quality of sexual life. methods: a quasi-experimental study. the current study was conducted in 84 men and their partners. the "personal information form", "premature ejaculation diagnostic tool (pedt)", "female sexual function index (fsfi)", and "sexual quality of life-female (sqol-f)" were used to collect data. behavioral therapy, consisting of a total of 6 sessions of 45 minutes, was applied once every two weeks.

Eligibility criteria:
inclusion criteria: * willingness to participate * having no communication barriers * literacy * age 18-45 years * having no diagnosis of sexual dysfunctions * having no medical illnesses (psychiatric diseases, pelvic anatomical disorder, post-menopause, etc.) that might affect the sexual function * having a spouse diagnosed with premature ejaculation according to dsm-5 criteria * having a spouse without any prior behavioral therapy for premature ejaculation * being a man diagnosed with lifelong premature ejaculation according to the issm criteria. * being married exclusion criteria: -men and their partners who did not meet all inclusion criteria were excluded from the present study.
long-term follow up study of subjects previously administered hmi 102

Conditions: Phenylketonuria; PAH Deficiency

Summary: an open-label, long-term follow up study of safety and efficacy in pku subjects with pah deficiency previously administered hmi 102

this long-term follow up study will evaluate the safety and efficacy of pku subjects with pah deficiency previously administered hmi 102. subjects will have already received a single dose of hmi-102 administered intravenously

Eligibility criteria:
inclusion criteria: * subject was previously administered hmi 102. * subject is able to understand the purpose and risks of the study and is willing to provide informed consent. * subject is able to comply with all study procedures and long-term follow-up. exclusion criteria: * participation in the study is not in the subject's best interest, in the opinion of the investigator.

Keywords: pku phenylketonuria pah deficiency phenylalanine adeno associated virus aavhsc15
misdiagnosis between interstitial lung disease and cardiac patients

Conditions: ILD

Summary: aim of the study to determine the frequency misdiagnosis of cardiac congestion as interstitial lung disease based on initial high resolution ct interpretation alone. to identify specific hrct findings that are more commonly associated with misdiagnosis versus correct diagnosis of the underlying condition. to establish diagnostic criteria or hrct patterns that distinguish cardiac congestion from interstitial lung disease

observational study of 150 patients found that cardiac congestion was misdiagnosed as interstitial lung disease in 24% of cases on initial hrct imaging alone. echocardiography and clinical correlation were needed to make the correct diagnosis . misdiagnosis can lead to inappropriate treatment with immunosuppressive drugs which could exacerbate right heart failure in patients who actually have cardiac congestion. correct diagnosis is important for prognosis and management. subtle findings like upper lobe predominance of opacities, septal lines and a mosaic attenuation pattern on hrct favor interstitial lung disease, while diffuse ground glass with central and perihilar distribution favors cardiac congestion . associated findings on hrct like enlarged cardiac silhouette, pleural and pericardial effusions help suggest the diagnosis of cardiac congestion over idiopathic interstitial pneumonia . integrating clinical data on risk factors for heart failure, echocardiography findings and follow-up imaging response to diuretic therapy can help differentiate the two conditions when hrct is non-specific

Eligibility criteria:
inclusion criteria: * patients who underwent hrct imaging of the chest for evaluation of suspected interstitial lung disease * initial radiology report included a definitive diagnosis of interstitial lung disease patterns * age 18+ years * no prior history of pulmonary or cardiac exclusion criteria: * inconclusive or unclear initial hrct report * underlying diagnosis other than interstitial lung disease or cardiac congestion
the effect of virtual reality (vr) versus conventional vestibular rehabilitation and progressive muscle relaxation (pmr) to improve balance and stress among patients of persistent postural perceptual dizziness (pppd).

Conditions: Persistent Postural Perceptual Dizziness

Summary: to compare the effect of virtual reality (vr) versus conventional vestibular rehabilitation and progressive muscle relaxation (pmr) to improve balance and stress among patients of persistent postural perceptual dizziness (pppd).

through this randomized controlled trial, we evaluate the effectiveness of three modern interventions in patients with persistent postural perceptual dizziness. in order to study the novel facets of pppd and to cover a large research gap, it is necessary to explore the psychological and physiological aspects of pppd. at individualized levels, this study aimed to enable patients to become more independent in their social and personal lives by overcoming stress and balance issues. socially, it reduces stigma by raising awareness, promoting understanding, providing better health access, facilitating communities, and promoting a more supportive and inclusive environment. this research can refine rehabilitation therapies at the institutional level and enhance health care provider training. it increases treatment and resource allocation, leading to better outcomes in the field. it provides a new platform for research.

Eligibility criteria:
inclusion criteria: * age groups ranging 18-25 years and having symptoms of dizziness, and lightheadedness over the period of \&gt;3months while having predisposing stress factor. the individuals who are ready to take part willingly in the follow up sessions should be included in the research exclusion criteria: * the participants who have any other neurological disease and cause of dizziness are excluded from this study. there should be no history of smoking, drug abuse and alcohol, and any other neurological condition that affects the balance. subjects with active meniere's disease /bppv/bilateral vestibulopathy are also excluded.
thrombosomes for expanded access use

Conditions: Bleeding

Summary: expanded use of thrombosomes where a clinical trial with thrombosomes is not an option, cellphire may elect to provide the sponsor/investigator (s/i) expanded access to its investigational product, thrombosomes.


Eligibility criteria:
inclusion criteria: 1. subject has presented with who grade 2 or higher bleeding which requires treatment with platelet therapy and there is limited availability of platelets or no other approved clinical alternative. 2. evidence from the facility blood bank/medical director that there are no approved platelet products available for transfusion, or the patient is refractory to platelet transfusion. exclusion criteria: 3. clinical circumstances of a history of thrombosis, thromboembolism, or vascular occlusion/ischemia in the prior six months such as defined by a past history of current diagnosis of one or more of the following: * arterial or venous thromboembolic disease including acute coronary syndrome * peripheral vascular disease * arterial or venous thrombosis (except when a prior history of central line thrombosis has resolved) * myocardial infarction (mi) * stent placement * valve replacement and/or repair * sinusoidal obstruction syndrome (veno-occlusive disease)
the effect of acupressure on fatigue

Conditions: Interventional

Summary: in this study, it is aimed to determine the effect of acupressure on fatigue in nursing students.

in this study, 68 nursing students were randomly assigned to the acupressure and placebo (sham) acupressure groups. in the acupressure group (n=34), compression was applied to the 7th point of the heart meridian (ht7), the 4th point of the large intestine meridian (li4), the 36th point of the stomach meridian (st36), and the 6th point of the spleen meridian (sp6). depending on the preparation and compression time at each point, the session duration of each student lasted an average of 20 minutes. in the sham group (n=34), pressure was applied approximately 1-1.5 cm away from the ht7, li4, st36, sp6 points. in the sham group, the acupressure application time lasted for an average of 20 minutes. at the end of the application, after the data collection process was completed, the sham group was taught the correct acupuncture points. students applied acupressure three times a week for a total of 12 sessions for four weeks. data were collected before and four weeks after the application in the acupressure and sham acupressure groups.

Eligibility criteria:
inclusion criteria: * students studying at mersin university faculty of nursing as 4th grade during the data collection date, * those who agree to participate in the study, * no deformity or lesions in the areas where acupressure will be applied * no acupressure experience * no sleep disorder diagnosis and no medical treatment * no diagnosis of anxiety disorder and no medical treatment no diagnosis of depression and no medical treatment * coffee, cigarette and alcohol-free, * no mental illness, * able to understand and speak turkish and * those who signed the informed consent form will be included in the study. exclusion criteria: * students studying at mersin university faculty of nursing outside the 4th grade during the data collection date, * those who do not agree to participate in the study, * those who have any deformity or lesion in the areas where acupressure will be applied * experienced with acupressure * diagnosed with sleep disorder and receiving medical treatment * diagnosed with anxiety disorder and receiving medical treatment * diagnosed with depression and receiving medical treatment * coffee, cigarette and alcohol addiction, * having mental illness, * who cannot understand or speak turkish * those who do not sign the informed consent form will not be included in the study.

Keywords: fatigue nursing students acupressure
properties of absorbable and nonabsorbable suture material in dental surgery

Conditions: Suture Adverse Reaction; Suture; Complications, Mechanical; Suture Failure During Surgical Operation; Suture Related Complication; Suture Rupture; Suture; Complications, Infection or Inflammation; Suture Line Infection

Summary: a suture is a biomedical device that is made of natural or synthetic materials. sutures are used to close tissue surfaces until wounds heal and regain their ability to withstand normal stresses. although different suture materials are available for various dental procedures, clinicians commonly neglect to select sutures based on their mechanical properties and capabilities. instead, clinicians rely on their clinical experience to determine which suture material will suffice for wound closure and healing. to our knowledge, there have been no published studies detailing the results of mechanical testing on sutures after clinical application. the aim of this study is to clinically, histologically, and mechanically assess the four common sutures used in periodontal and dental surgery, with the hopes of providing clinicians with a guide that will allow them to choose sutures based on the clinical, histological, mechanical properties that best fit the stress and strain applied to the wound.


Eligibility criteria:
inclusion criteria: subject must have read, understood and signed the informed consent form. subject must require either open flap debridement surgery or implant placement (one to three consecutive teeth replacement) surgery. subjects must be males or females who are a minimum of 20 years of age. no history of periodontal or implant surgery at the investigational area site within the past 12 months. periodontal probing depths ≥5 mm interdentally at the implant site. subjects that received single interrupted sutures for flap closure following surgical procedures. exclusion criteria: * subject is part of a vulnerable population will be excluded. female subjects who are pregnant or lactating, or who intend to become pregnant during the study period following entrance into the study. subjects with a systemic disease that would preclude periodontal surgery. subjects who are smokers or chew tobacco. subjects that received periodontal dressing on the surgical area. subjects with the presence of acute infectious lesions in the areas intended for surgery. subjects with conditions or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results.

Keywords: dental suture suture infection mechanical properties absorbable sutures non-absorbable sutures histological properties
cha2ds2-vasc score as a predictor of thrombus burden and clinical outcomes in patients undergoing ppci.

Conditions: STEMI

Summary: aim of the work is to evaluate the use cha2ds2-vasc score in predicting no-reflow phenomenon and its impact on short term primary percutaneous coronary intervention outcomes (in-hospital mortality) and long term (6 months) incidence of mace ( major adverse cardiac event ) in patients with st segment elevation myocardial infarction who underwent primary primary percutaneous coronary intervention

large intracoronary thrombus burden is known to be associated with reduced procedural success during the primary percutaneous coronary intervention (ppci), larger infarct size, increased ischemic complications and mortality. no-reflow phenomenon is related to higher incidence of complications, and short- and long-term morbidity and mortality in acute stemi patients. although many risk factors were suggested, tragically there's no widely accepted risk stratification method to anticipate these complications. cha2ds2-vasc score is a sum of several risk factors for thromboembolism. it is considered a clinical indicator of thromboembolic diseases and is recommended by the current guidelines for the estimation of thromboembolic events in patients with atrial fibrillation. in this study, we evaluate the use cha2ds2-vasc score as a novel rapid simple tool for predicting no-reflow and clinical outcomes among patients with stemi who underwent primary pci.

Eligibility criteria:
inclusion criteria: * subjects with stemi and undergoing primary primary percutaneous coronary intervention. * patient loaded pre-procedural with using with aspirin 300 mg plus ticagrelor 180 mg or clopidogrel 600 mg. exclusion criteria: * patients with chest pain more than 48 hours * patients not eligible for primary pci
dose exploration of ciprofol for sedation in gastrointestinal endoscopic diagnosis and treatment of obese patients.

Conditions: Gastric Cancer; Gastric Ulcer; Intestinal Polyps; Intestinal Cancer

Summary: ciprofol is a new anesthetic, which combines with γ- aminobutyric acid-a (gabaa) receptor. ciprofol has shown equivalent anesthetic efficacy of propofol at 1/4 to 1/5 of the dosage. ciprofol has the pharmacodynamic characteristics of rapid onset, stable and rapid recovery. phase iii clinical results showed that the incidence of injection pain and respiratory and circulatory depression of ciprofol was lower than that of propofol. therefore, ciprofol has a good application prospect in sedation for gastrointestinal endoscopy, especially for obese patients. in the current study, we would explore the proper dose of ciprofol in sedated gastrointestinal endoscopy in obese patients.


Eligibility criteria:
inclusion criteria: 1. age, ≤18 and ≤60 years, no gender limit 2. undergoing routine gastrointestinal endoscopic diagnosis and treatment 3. american society of anesthesiologists (asa) classification i-ii 4. body mass index(bmi) ≥28kg/m\^2 5. clearly understand and voluntarily participate in the study; provide signed informed consent exclusion criteria: 1. unhealthy alcohol drinking, defined by more than three standard drinks per day (≈10 g alcohol , equivalent to 50 g of strong chinese spirits) 2. drug abuse history within 3 months before the screening period 3. people who are known to be allergic to eggs, bean products, opioids and other drugs, propofol, etc 4. the researcher believes that patients should not participate in this trial

Keywords: sedation gastrointestinal endoscopy obese patient ciprofol
interhemispheric anterior delta desynchronization in children who present to the emergency department with acute concussion: a proof of concept study

Conditions: Concussion, Mild Traumatic Brain Injury

Summary: approximately 150,000 children present each year to emergency departments (eds) in the us with concussion and many more are treated by primary care physician, or outpatient specialists. concussion is defined as a traumatically induced transient disturbance of brain function and involves a complex pathophysiological process. there is a variety of symptoms related to concussion, and the diagnosis of concussion requires the use of symptom-checklist. since there is a various degree of the severity of those symptoms, the diagnosis is a subjective one and lacks sensitivity. one major problem is that approximately one-third of the children with concussion experience ongoing somatic, cognitive, and psychological or behavioral symptoms, referred to as persistent post-concussion symptoms. a recent study that investigated the validity a 12-point ppcs risk score revealed that it had modest validity (0.71). moreover, one of the greatest concerns is the child's schedule return to activity. since the basic mechanism for concussion is acceleration/ deceleration movement of axons, it is likely to be expressed in desynchronization of delta wave activity between anterior hemispheres as seen in pathological problems related to attention and/ or working memory). the aim of this proof-of-concept study is to find-out whether interhemispheric desynchronization of delta waves (ihdd) in the anterior hemispheres can identify acute concussion in children. if the investigators find that ihdd can accurately diagnose acute concussion, a second objective will be to examine whether this index can be a useful tool in the follow up of patients with persistent post-concussion symptoms.


Eligibility criteria:
inclusion criteria: * study group will include children aged 11-18 years with diagnosis of acute concussion based on the rpsq. (eisenberg et al., 2013; harmon et al., 2013) * controls will be healthy children who will be admitted to the ed due to an isolated limb injury such as laceration, contusion or fracture and are not painful. nonverbal or non-cooperative children will be excluded from the study. exclusion criteria: * nonverbal or non-cooperative children. * lack of inform consent.

Keywords: concussion mild traumatic brain injury eeg