Kornimate/medical-research-clean huggingface dataset:
accessible acupuncture for the warrior with acute low back pain

Conditions: Acupuncture; Low Back Pain

Summary: the objective of this study is to determine if auricular acupuncture and/or the acupuncture point governor vessel 26 (gv26) with manual tonification is superior to conservative management (nsaids) at reducing acute low back pain (less than 4 weeks in duration).

the study will be a randomized control trial of active duty and dod beneficiaries aged 18 years or older with complaints of acute lower back pain (four weeks or less in duration). subjects will be randomized into one of four study groups receiving either 1) nsaids only (naproxen 500mg by mouth twice a day as needed) or 2) acupuncture to include use of gv 26 with manual tonification (twisting or rotating the needle) plus nsaids (naproxen 500mg by mouth twice a day as needed) or 3) battlefield acupuncture in both ears (which includes the points cingulate gyrus, thalamus, omega-2, point zero and shen men) plus nsaids (naproxen 500mg by mouth twice a day as needed) or 4) gv26 with manual tonification + battlefield acupuncture in both ears (which includes the points cingulate gyrus, thalamus, omega-2, point zero and shen men) plus nsaids (naproxen 500mg by mouth twice a day as needed). we seek to determine if acupuncture is superior to conservative management alone in treating acute low back pain (4 weeks or less in duration).

Eligibility criteria:
\*\*patients must be able to get care at nellis air force base (a military installation) in order to participate in this study\*\* inclusion criteria: * male and female active duty and dod beneficiaries aged 18 years or older. * complaints of acute back pain (4 weeks or less in duration). exclusion criteria: * known history of underlying rheumatologic condition. * chronic low back pain (greater than 4 weeks in duration). * contraindications to nsaid use (including peptic ulcer disease, underlying coagulopathy, severe coronary artery disease, underlying renal disease, allergy, thrombocytopenia). * red flag symptoms of low back pain (to include bowel or bladder incontinence, sudden onset sensorineural deficits, loss of sensation in the perineal region). * requiring narcotic use to control symptoms. * patients currently taking opioid medications. * pregnant, may be pregnant, or attempting to become pregnant

Keywords: acupuncture low back pain
a comparison of emtricitabine and stavudine used with didanosine plus efavirenz in hiv-infected patients who have not taken anti-hiv drugs

Conditions: HIV Infections

Summary: the purpose of this study is to compare the safety and effectiveness of emtricitabine and stavudine when given with didanosine plus efavirenz to hiv-infected patients.


Eligibility criteria:
inclusion criteria patients may be eligible for this study if they: * are at least 18 years old at the time of screening. * have plasma hiv-1 rna loads (level of hiv in your blood) of 5,000 or more copies/ml at the time of screening. * have not used any anti-hiv therapy for more than 2 days. * have a negative pregnancy test within 22 days of starting study drugs. * can be reached by telephone. exclusion criteria patients will not be eligible for this study if they: * are pregnant or breast-feeding. * use alcohol or illegal drugs that, in the opinion of the principal investigator, may interfere with the patient's ability to follow the dosing schedule and protocol evaluations. * are being treated for active tuberculosis. * are using astemizole, cisapride, midazolam, triazolam, ergot derivatives, st. john's wort, or drugs for a mental disorder. * have a history of a serious mental disorder. * are unwilling to use an effective barrier method of birth control during the study (for women who can get pregnant). * have a history of opportunistic infections and cancers (mycobacterium avium complex, cytomegalovirus, toxoplasmic encephalitis or disseminated toxoplasmosis, cryptosporidiosis, isospora belli, progressive multifocal leukoencephalopathy, visceral kaposi's sarcoma, and lymphoma). patients with past episode of pulmonary tuberculosis, pneumocystis carinii pneumonia, or isolated cutaneous kaposi's sarcoma are allowed. medication for the prevention of pcp (tmp/smx, nebulized pentamidine, and atovaquone) is allowed. * have peripheral neuropathy (a painful condition affecting the nervous system) or history of peripheral neuropathy. * cannot take medicine by mouth or have severe chronic diarrhea within 30 days before beginning the study. * cannot eat 1 or more meals a day because of chronic nausea, vomiting, or abdominal or esophageal discomfort. * have had a serious illness or injury within 30 days of screening. treatment must have been completed for 14 days prior to study entry. * have a history of aids-defining opportunistic infection, except for tuberculosis or infection of the stomach or intestines.

Keywords: hiv-1 didanosine drug therapy, combination reverse transcriptase inhibitors anti-hiv agents deoxycytidine efavirenz
adjuvant albumin-bound paclitaxel versus taxanes in breast cancer: a real-world study

Conditions: Breast Cancer

Summary: this is a prospective, multi-center, real-world study designed to evaluate the efficacy and safety of albumin-bound paclitaxel versus paclitaxel or docetaxel in adjuvant treatment of breast cancer.


Eligibility criteria:
inclusion criteria: 1. female patients aged from 18 to 70 years old; 2. histologically confirmed as invasive breast cancer; 3. eastern cooperative oncology group (ecog) performance status of 0 or 1; 4. participants achieved complete tumor resection by radical mastectomy, modified radical mastectomy or breast-conserving surgery with negative margins; 5. ac-t adjuvant chemotherapy is planned after breast cancer surgery; 6. participants with her-2 negative breast cancer at high risk of recurrence who meet any of the following conditions: 1) hr positive, and ≥4 positive lymph nodes or 1-3 positive lymph nodes with other risk of recurrence \[such as high ki67 expression (≥20%), t \> 2 cm, age \ 2 cm; 7. lvef ≥ 50%; 8. participants had good compliance with the planned treatment and follow-up, understood the study procedures of this study, and signed informed consent form. exclusion criteria: 1. in the past and present, participants with severe cardiac disease or discomfort , including but not limited: 1) high-risk uncontrolled arrhythmia, atrial tachycardia (heart rate \> 100/min in resting state), significant ventricular arrhythmia (ventricular arrhythmia) or higher atrioventricular block (second-degree type 2 \[mobitz 2\] atrioventricular block or third-degree atrioventricular block); 2) angina pectoris requiring anti-angina medication; 3) clinically significant valvular heart disease; 4) ecg showing transmural myocardial infarction; 5) uncontrolled hypertension (eg systolic blood pressure \> 180mm hg or diastolic blood pressure \> 100mmhg); 6) myocardial infarction; 7) congestive heart failure; 2. participants who have received prior any systematic treatment for breast cancer; 3. participants with bilateral invasive breast cancer; 4. breast cancer with distant metastasis; 5. grade 2 or higher sensory or motor neurotoxicity was present as assessed by ctcae v5.0; 6. participants have the following serious illnesses or medical conditions, including but not limited: 1) history of serious neurological or psychiatric disorders, including psychosis, dementia, or epilepsy, that prevent understanding and informed consent; 2) active uncontrolled infection; 3) active peptic ulcer, unstable diabetes; 7. previous or current existence of other malignant tumors other than breast cancer; 8. severe liver and kidney dysfunction; 9. the presence of any myelodysplastic and other hematopoietic disorders; 10. participants who are known to be allergic to the active or other components of the study treatment; 11. participants who are pregnant, breastfeeding, or refuse to use adequate contraception prior to study entry and for the duration of study participation; 12. participants who were judged by the investigator to be unsuitable for this study.
correlation between oct and mferg findings with va after vitrectomy surgery for retinal detachment

Conditions: Retinal Detachment

Summary: correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity after vitrectomy surgery for retinal detachment.

although the anatomical success rate of vitreoretinal surgery has improved over the last decade, visual results remain compromised? patients with macula-off retinal detachments (rds) can have poor visual recovery, specific color vision defects, or metamorphopsia postoperatively despite successful retinal reattachment. in these cases, subtle changes in the foveal structure may be causing visual disturbances that can be difficult to identify during standard clinical examinations such as slit lamp biomicroscopy or binocular indirect ophthalmoscopy .reported a possible association between incomplete visual recovery and the presence of residual subretinal fluid (srf) postoperatively. optical coherence tomography (oct) is a non-invasive technique that provides information about the morphology of the retina, and especially of the macular area in vivo. some studies support the idea that oct determines structural changes in the macula that are correlated with subjective visual function, including visual acuity (va) in patients with vitrectomy for retinal detachment. additionally, multifocal electroretinogram (m ferg) evaluation can be helpful in assessing macular function in post-vitrectomy. however, to date, there are relatively few reports concerning the combined use of oct and m ferg for the correlation between retinal morphology and function of the macula in patients with vitrectomy for retinal detachment surgery. the purpose of our study is to determine whether a significant correlation exists between the amplitude of m ferg, visual acuity, and the morphological oct changes by in the macula after vitrectomy for retinal detachment

Eligibility criteria:
inclusion criteria: * patients with successful vitrectomy for retinal detachment. exclusion criteria: * the patients who had vitrectomy for reasons other than retinal detachment surgery * patients who had done scleral buckle surgery * patients with media opacity are prevented from doing retina imaging. * failed or recurrent vitrectomy surgery
weekly cisplatin or nedaplatin concurrent with intensity-modulated radiation therapy in nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: this is a randomized phase iii study to evaluate efficancy of weekly cisplatin or nedaplatin concurrent with intensity-modulated radiation therapy in nasopharyngeal carcinoma (npc).


Eligibility criteria:
inclusion criteria: * pathologically confirmed untreated npc patients * t1-2n1-3m0 or t3-4nxm0 * 18-70 years old * with mri examinations * ecog ≤ 2 * with written consent exclusion criteria: * with a second cancer * pregnancy * with other severe diseases (blood,liver ,kidney or heart diseases) * could not be staged properly * without written consent
study of hypofractionated proton beam radiation therapy for prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this study is to determine hypofractionated conformal proton beam radiation therapy of prostate cancer can achieve similar treatment benefits as our current institutional standard with conventional fractionation.

radiation therapy has a long and established role in the curative treatment of organ-confined prostate cancer. however, the optimal radiation dose and treatment schedule remain unknown. the use of hypofractionation has a long and generally successful history in conformal proton beam therapy. several reports detailing the efficacy and safety of hypofractionated conformal radiation therapy (with x-rays) of prostate cancer can be found in the literature. hypofractionated conformal proton beam radiation therapy has become our institutional routine for the treatment of numerous solid tumors. the purpose of this study is to determine if a shortened overall treatment schedule will result in equivalent tumor control rates and no increased side effects as compared to our current institutional standard treatment of an equivalent dose given over a longer period of time.

Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma within 180 days of registration * history \& physical exam, including digital rectal exam (dre), within 8 wks prior to registration * histologic evaluation of prostate biopsies at llumc, with gleason score assignment * clinical stage, tumor stage (t1-t2c) * prostatic specific antigen (psa) less than 10 ng.ml within 180 days prior to registration exclusion criteria: * prior or concurrent invasive malignancy * evidence of distant metastasis

Keywords: hypofractionation proton beam radiation
cohort study of endometriosis at different sites

Conditions: Recruitment

Summary: to present the clinical characteristics of pelvic or extra-pelvic endometriosis and explore the potential risk factors of pathogenesis and recurrence by comparing patients with endometriosis at different sites

endometriosis is a chronic inflammatory disease defined as the presence of endometrial glands and stroma outside of the internal epithelial lining of the cavum uteri, affecting up to 10% of reproductive age women. it is rarely found in extrapelvic locations.this form of endometriosis may be difficult to diagnosis due to pleomorphic presentation. despite complete excision with a safe margin and histopathological examination has been considered as definitive diagnosis and primary therapeutic treatment for extra-pelvic endometriosis, what is understood mainly comes from case reports and retrospective observations with limited number of cases. moreover, approximately 6%-14% of patients with pem who had underwent narrowly operative resection still suffered recurrent lesions, while risk factors were barely identified. patients with endometriosis at different sites in our hospital were collected for analysis of clinical characteristics namely demographic information, medical history, surgical records, pathological and imaging reports, serum levels of cancer antigen 125 (ca125), peri-operative medication. during long-term follow-up, prognosis of individuals could be identified by telephone or clinical interview. based on data from medical records or clinical observation, risk model predicting recurrence will be established by comparing patients with different outcomes or exposed to different risk factors. thus, management of endometriosis might be improved. hopefully, pathogenesis of recurrent and primary endometriosis might be explained.

Eligibility criteria:
inclusion criteria: * patients who were clinically diagnosed with endometriosis at different sites (pelvic and/or extra-pelvic) and received surgical treatment at pumch exclusion criteria: * i). underwent bilateral oophorectomy in the operation, ii). had incomplete records of inpatient management, iii). had no post-operative outpatient follow-up, iv). combined with malignancy.
effect of virtual reality application on pain, anxiety and comfort during chest tube removal procedure

Conditions: Chest Tube Removal

Summary: chest tubes are used to eliminate possible acute or chronic problems that may occur after trauma or surgical interventions to the chest area. this process, which aims to drain the fluid, blood or air accumulated in the pleural area, works with the support of closed underwater drainage systems. the chest tubes, which remain in place for a long time, fuse with the endothelium lying in the chest cavity. for this reason, the adhesions formed with the fusion cause very severe acute pain in the patient with the pulling force applied during removal.the high level of pain of the person will cause an increase in the level of anxiety and a decrease in the level of comfort. the anxiety experienced by the patients will also reduce the tolerance to pain.it has been observed that the use of virtual reality in the field of health significantly reduces the level of pain and anxiety during medical procedures, shortens wound healing and hospital stay, and increases compliance with treatment.in the literature, no studies were found in which the effects of virtual reality application on pain, anxiety and comfort were evaluated in patients whose chest tube was removed.thereforee, this study was conducted to evaluate the effect of virtual reality application against all these negative situations.


Eligibility criteria:
* study inclusion criteria: * must be between the ages of 18-65, * must have undergone coronary artery bypass graft surgery and have a chest tube, * must participate in the study voluntarily, * must not have vision or hearing problems, * must not have disorientation in place and time, * must not have any psychiatric disorders, * study exclusion criteria: * those with chronic pain and routinely using painkillers, * those using painkillers before the procedure, * those with problems such as migraine, vertigo, dizziness, * patients using prescription glasses and those having vision problems without glasses were not included in the study.

Keywords: virtual reality pain anxiety comfort
association between abo polymorphism and gastric/colorectal cancers

Conditions: Gastric Cancer; Colo-rectal Cancer

Summary: to assess abo gene polymorphism (rs8176746) in the patients histopathologically confirmed gastric and/or colorectal cancers relative to healthy controls by real time pcr.

the abo blood group system was discovered by the austrian pathologist karl landsteiner in 1901, who classified the blood groups based on the presence of a and b antigens on the surface of red blood cells after noting patterns of agglutination during blood transfusion. since the discovery of the abo blood group system , several studies investigating the relationship between the abo blood group system and various diseases have been conducted , cancer included . first association between abo blood group and cancer risk was reported in 1953 in the english patients with gastric cancer. gastric cancer is one of the most common malignant tumors of the digestive system , worldwide, gastric cancer is still the fourth most common cancer and the second most common cause of cancer death . the development of gastric cancer is caused by the interaction of genetic and environmental factors , abo blood grouping is one of the most stable genetic factors. this association is also observed with other gastrointestinal malignancies, including colorectal cancer which considered the third common cancer in both women and men and responsible for approximately 10% of all cancers, and the third most common cause of cancer related mortality for men and fourth for women . the abo is also the first blood group system defined at the gene level . snp is a single nucleotide polymorphism, is a germ line substitution of a single nucleotide at a specific position in the genome that is present in a sufficiently large fraction of considered population , snp may act as biological markers, as they can relate to the genes that are associated with various complex diseases as heart diseases, diabetes, cancer ... etc. in previous studies , significant association between abo gene snp (rs8176746) , h. pylori infection, gastric and pancreatic cancer were found , as they observed that this gene snp was associated with decreased risk of these disorders.

Eligibility criteria:
inclusion criteria: * patients that histopathologically confirmed gastric and/or colorectal cancer. * males and females. exclusion criteria: * presence of other haematological , autoimmune disorders or other malignancies.
use of an osteoconductive scaffold in acl-reconstruction

Conditions: ACL - Anterior Cruciate Ligament Rupture; ACL; ACL Injury

Summary: primary objective of the study is to evaluate efficacy of the surgical technique for acl reconstruction using an osteoconductive scaffold, enlaced into the hamstring tendon autograft, compared to the traditional technique.

reconstruction of the anterior cruciate ligament (acl) using autograft tissue is currently recommended as the standard of care following an acl tear or rupture, with the bone-tendon-bone (btb) graft and hamstring tendon graft the most common. although a btb autograft is widely recognized to offer high mechanical performance and rapid graft healing, these advantages come at the cost of a longer surgery time and higher risk of severe patient discomfort at the graft harvest site. use of a hamstring tendon autograft is less painful, but is generally slower to heal with higher risk of mechanical graft failure due to poor bone ingrowth. the aim of the current study is to augment graft-to-bone incorporation by use of an osteoconductive scaffold enlaced into the hamstring tendon autograft. this bovine derived composite bone substitute is inserted into the articular aperture of the femoral bone tunnel and should provide an osteoconductive / osteoinductive environment at a biomimetic attachment site leading to improved secondary graft-fixation and a reduced incidence of tunnel widening. primary objective of the study is to evaluate efficacy of the surgical technique for acl reconstruction using an osteoconductive scaffold, enlaced into the hamstring tendon autograft, compared to the traditional technique. secondary objectives aim to assess the clinical outcome of the interventional treatment including patient subjective knee function and objective measures of knee stability.

Eligibility criteria:
inclusion * acute unilateral complete tear of the acl that occurred within 18 weeks before planned surgery and requires reconstruction of the * informed consent as documented by signature exclusion criteria: * prior acl reconstruction or other surgical procedure on the affected knee. * prior fracture of the affected leg. * multi-ligament reconstruction. * previous or current acl injury on contra-lateral leg. * medical condition or comorbidity that would interfere with study participation. * the patient is mentally compromised. * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * other clinically significant concomitant disease states (e.g. renal failure, hepatic dysfunction, cardiovascular disease, etc.).

Keywords: acl reconstruction osteoconductive scaffold bone tunnel widening