Kornimate/medical-research-clean huggingface dataset:
nutritional intervention for patients with multiple cancer types

Conditions: Cancer

Summary: to evaluate the nutritional status of patients with different types of tumors by continuous nutritional intervention and follow-up intervention in the perioperative period,and the impact on progression-free survival/survival and quality of life.


Eligibility criteria:
inclusion criteria: * ① age ≥18 years old, \<80 years old, male or female; ② the patient signed the informed consent and volunteered to participate in the study; ③ patients with malignant tumors (laryngeal cancer, esophageal cancer, lung cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer) evaluated by clinical stage ii to iv; ④ patients undergoing tumor surgery; ⑤ patients with nrs 2002 score ≥ 3 after management risk screening; ⑥ basic reading and communication skills; ⑦ have the ability to act; patients with a life expectancy greater than 6 months; exclusion criteria: * ① acute onset of chronic disease; ② pregnant or lactating women; ③ patients with contraindications and no tumor surgery; (4) patients with malignant tumors (laryngeal cancer, esophageal cancer, lung cancer, stomach cancer, colorectal cancer, liver cancer, pancreatic cancer) were confirmed by pathology and/or cytology after surgery; ⑤ combined with cognitive dysfunction, mental disorder, consciousness disorder or unwillingness to cooperate; ⑥ patients with severe gastrointestinal symptoms, liver and renal insufficiency (alanine aminotransferase alt≥2 times the upper limit of normal value; total bilirubin tbil≥2 times the upper limit of normal value; creatinine cr≥2 times the upper limit of normal value); (7) patients with two or more types of tumors; long-term bed rest, hemiplegia or coma; ⑨ severe dysfunction of liver, kidney and other organs; ⑩ allergy or intolerance to nutrients or their main components (such as lactose or galactose, etc.).

Keywords: nutrition prognosis
evaluation of the curative effect of ru-yi-jin-huang-saan

Conditions: Colles' Fracture

Summary: the purpose of this study is to assess the efficacy and safety of ru-yi-jin-huang-saan for the treatment of colles' fracture.

according to the definition of the world health organization, taiwan officially entered the aged society in 2018. the population over the age of 65 exceeds 14% of the total population. based on this, it is estimated that we will enter a super-aged society in 2026. because the older the age, the higher the rate of bone loss, and the higher the risk of osteoporosis, the easier it is to fracture due to falls. the incidence of bone fracture is directly proportional to the aging population. traditional chinese medicine(tcm) interventional fracture treatment has a long history and experience. many recent studies show that tcm is benefit to reduce risk of total hip replacement and has a positive influence on the prevention of osteoporotic fracture. in drug mechanism research, some chinese herbal medicine has been proved to promote bone fracture healing . although most of these researches have been confirmed in the laboratory, little information is available on true patients. in clinical we observe a lot of topical chinese medicine been used after fracture, so the purpose of this thesis is to investigate the effective of topical chinese herbal paste. this study may lead to build the usage of guideline after fracture.

Eligibility criteria:
inclusion criteria: 1. people who are over 20 years old and have no lack of mental ability can understand the content of the experiment and are willing to participate in it. 2. patients with colles' fracture receive surgical fixation(orif). exclusion criteria: 1. people are unable to cooperate with experiments and fill out questionnaires. 2. patients have wounds on the back of their wrists. 3. patients are allergic to traditional chinese medicine for external applications or have used other traditional chinese medicine for external applications. 4. patients have cancer, stroke, and systemic diseases such as severe anemia, thyroid disease, uncontrolled diabetes, etc. 5. pregnant woman.
infant medical records: case report proposal

Conditions: Congenital Disorders

Summary: infants with congenital long qt syndrome (lqts) and 2:1 atrioventricular block (avb) have been recognized as a clinical subset of children with lqts. the purpose of this study is to describe the clinical course and outcome of a patient with congenital long qt syndrome (lqts).

it has been previously reported that 2:1 avb in neonatal lqts seems preferentially associated with herg mutations . it has also been reported in association with the scn5a gene. we report on a neonate with congenital lqts and congenital complete heart block who experienced frequent episodes of torades des pointe and ventricular tachycardia, which, over the first 2 days of life, was recalcitrant to traditional therapy of beta-blockers and other antiarrhythmics. eventually hypotension necessitated the use of an epinephrine infusion, which halted the ventricular tachyarrhythmias. a pacemaker was implanted once the infant was stable and, currently, he is thriving. genetic analysis revealed a herg mutation. for this study, we will need access to the infant's inpatient and outpatient medical records at children's healthcare of atlanta at egleston children's hospital and sibley heart center cardiology to include his age, date of birth, medical record number, inpatient labs, inpatient echo reports, outpatient echo reports, inpatient and outpatient ekg's, inpatient pharmacy records, the results of his genetic analysis, his history and physical, transfer notes, daily progress notes, consultation reports and operative reports from his admission beginning 9/30/04.

Eligibility criteria:
inclusion criteria: * congenital long qt syndrome single case report exclusion criteria: * single case report

Keywords: pediatric cardiac long qt syndrome pacemaker herg mutation
shift work and risk of cardio-vascular disease

Conditions: Shift-Work Sleep Disorder

Summary: the purpose of this research is to test the hypothesis that those with non-traditional work schedules (e.g. shift workers) have a higher cardio-metabolic risk than those with traditional work schedules (e.g. day workers), and that both accumulated sleep debt and the degree of circadian disruption predict the elevated cardio-metabolic risk. the findings of this research are expected to increase our understanding of physiologic tolerance to non-traditional work schedules and provide the basis for the development of methods for the early detection of adverse health effects and determine coping strategies for the millions of workers with non-traditional work schedules.


Eligibility criteria:
inclusion criteria: age 18 and older full-time workers- working between 7:00 a.m. and 7:00 p.m. employed full time at a medical center. non-traditional full-time workers- working between 7:00 a.m. and 7:00 p.m and between 7:00 p.m. and 7:00 a.m., employed full time at a medical center. exclusion criteria include: acute illness or recent change in medication. persons employed for less than 3 months at their current job -
impact of probiotics on the intestinal microbiota

Conditions: Colorectal Cancer

Summary: the purpose of this study is to assess the impact of probiotic administration (saccharomyces boulardii) on patients undergoing colorectal resections comparing to the routine protocol by assessing: (1)intestinal microbiota modulation using rt-pcr to measure cytokine in the mucosa; (2) assess postoperative complications, mainly infectious and mortality, as well as length of hospital stay

the intestinal microbiota, a complex and dynamic population of different bacterial species, under normal circumstances, represents an important contribution to the health of the host. this plays a key role by maintaining the integrity of the epithelial barrier and helping the development of mucosal immunity. however, under some stressful situations, such as after gastrointestinal surgery, infectious complications may be originated from the patient's own intestinal microbiota. this leads to the so called "gut origin of sepsis" hypothesis. on the other hand, under similar conditions, the supply of probiotics, the good bacteria, has been shown to be beneficial, despite few controversial results. therefore, it is important to carefully assess the efficacy of probiotics in the prevention and treatment of complications in surgical patients, as well as to evaluate the safety of its use.

Eligibility criteria:
inclusion criteria: * older than 18 years old * intend to undergo elective colon resection at the ufmg hospital exclusion criteria: * patients in use of steroids * patients unable to receive the probiotics for, at least, 7 days before the operation * changes to the operation strategy * patients that discontinued probiotic use * patients who had previously taken any probiotic or prebiotic

Keywords: probiotics cytokine short chain fatty acids complications colorectal surgery
regional vs general anesthesia in patients with hip fracture under treatment with clopidogrel

Conditions: Hip Fractures

Summary: this study compares general to regional anesthesia concerning morbidity and mortality in patients older than or equal to 65 years old who receive clopidogrel and are to be submitted in hip fracture surgery. half of participants will receive general anesthesia the first 48 hours and the other half will receive regional anesthesia after 5 days of the discontinuation of clopidogrel.


Eligibility criteria:
inclusion criteria: * patients older than or equal to 65 years old with hip fracture * native language greek and capable of speaking and writing * primary school graduated * is about to undergo in orthopedic surgery * participants should be available until the end of the prefixed end date of the research exclusion criteria: * severe hearing impairment and visual acuity * major cognitive impairment (mini mental state examination \<24) * medical history of central nervous system disease including stroke with neurological deficit * medical history of alcohol or drug abuse * dementia, parkinson disease, alzheimer disease * contraindication for general or regional anesthesia * severe contraindication for antiplatelet agent discontinuation * multiple failures * receiving other coagulants * no written consent

Keywords: hip fracture, general anesthesia, regional anesthesia, clopidogrel, cognitive impairment, mortality
real-world aliskiren use in diabetic patients

Conditions: Diabetes; Hypertension

Summary: the purpose of this study is to evaluate real-world patterns of aliskiren use with a focus of change in renal function following aliskiren initiation as well as to identify "triggering events" that lead to aliskiren initiation.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * patients ages 18 yeras and older * hypertension diagnosis * currently on at least 1 hypertensive medication * at least 2 lab measure before and after aliskiren initiation exclusion criteria: * inadequate chart records where microalbuminuria, serum creatinine and blood pressure data are not within 3-12 months prior to initiation of aliskiren * pregnancy * development of secondary renal disease unrelated to diabetes (such as nephritis) * terminal illness * aids/hiv other protocol-defined inclusion/exclusion criteria may apply

Keywords: diabetes aliskiren hypertension renal impairment
the impact of 3d patch one-suture fixation vs no fixation on chronic pain and recurrence in ⅲ inguinal hernia

Conditions: Inguinal Hernia

Summary: this study aims to compare the effects of one-stitch fixation and non-fixation of 3d patches on chronic pain and recurrence in type iii inguinal hernia. the primary outcome measures include hernia recurrence, chronic pain, etc.


Eligibility criteria:
inclusion criteria: 1. primary inguinal hernia 2. type iii inguinal hernia (internal annulus \>3cm) exclusion criteria: 1. age below 18 years or older than 80. recurrent hernia, incarcerated hernia,strangulated hernia, and other types of hernias. 2. patients not suitable for general anesthesia. 3. patients requiring open surgery. 4. patients requiring emergency surgery loss to follow-up or communication difficulties, or poor compliance.
safety and efficacy of samsung gems-h device training in sub-acute and chronic stroke

Conditions: Stroke; Chronic Stroke

Summary: a single-site, interventional, single-arm trial to evaluate the safety and efficacy on functional mobility following samsung gems-h (gait enhancing and motivating system - hip) device training in participants with sub-acute and chronic stroke.


Eligibility criteria:
inclusion criteria: * ≥ 30-days post stroke * age: 18-85 years * initial gait speed of ≥ 0.4 m/s and ≤ 0.8 m/s * adequate cognitive function (mmse score \>17) * ability to walk at least 10m with maximum 1 person assist * physician approval for patient participation * able to safely fit into device specifications and tolerate minimum assistance exclusion criteria: * ≤90 days post major orthopedic surgery (i.e. hip, knee, and/or ankle joint replacement) * ≤ 6 months post coronary artery bypass graft (cabg) or cardiac valve procedure * severe osteoporosis as indicated by physician medical clearance * serious cardiac conditions (hospitalization for myocardial infarction or heart surgery within 3 months, history of congestive heart failure, documented serious and unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living) * pregnancy * uncontrolled hypertension * lower extremity fracture * modified ashworth spasticity ≥3 in hip flexor or extensor * preexisting neurological disorders such as parkinson's disease, amyotrophic lateral sclerosis (als), multiple sclerosis (ms), dementia * history of: major head trauma, lower extremity amputation, non-healing ulcers of a lower extremity, ongoing active infections, legal blindness, or a history of significant psychiatric illness * participating in any other structured outpatient, home health physical therapy program, or another clinical trial that according to the principal investigator is likely to affect study outcome or confound results. tms-specific exclusion criteria * pacemakers, metal implants in the head region * history of unexplained, recurring headaches, epilepsy/seizures/skull fractures or skull deficits * medications that lower seizure threshold * history of concussion in last 6 months

Keywords: stroke exoskeleton
electromyographic evaluation of quadriceps during eccentric decline squat

Conditions: Patellar Tendinopathy

Summary: previous studies have generally investigated patellar tendon stiffness, cross-sectional area of patellar tendon, patellar tendon length, patellar force and patellafemoral forces during decline squat. however, there is just a few study about electromyographic (emg) activity during the eccentric squating, which is about rectus femoris (rf) recruitment. in the present study the investigators primarly aimed to quantify the activation of rf, vastus lateralis (vl), and vastus medialis obliqus (vmo) during eccentric squat on different decline angle (0, 5°, 10°, 15°, 20°). an additional purpose of our study was to compare the changes in muscle activation at various arc of knee flexion motion (degrees of 0-30, 30-60, 60-90, 0-60, 30-90, 0-90).the investigators hypothesised that the recruitment of rf, vl, and vmo during eccentric squat would differ according to decline angle and arc of motion.

the squat procedure in each condition will be repeated 10 times on a treadmill. the treadmill will be used to adjust the degree of decline in a standard manner. there will be a metronome to keep the speed of exercise in the same rhythm. all squats will be performed with a weighted barbell. the weight of it will be set as in ratio 30% of the participant's body weight

Eligibility criteria:
inclusion criteria: * had exercised regularly (\>3 days in a week) for at least six months. * older than 18 years old. exclusion criteria: * had patellofemoral pain, knee pain otherwise unrelated to the knee extensor mechanism and other injuries that would restrict performance of the tasks (e.g. ankle pathology).

Keywords: eccentric squatting electromyografic activation exercise patellar tendinopathy
effectiveness of bioactiveglass air abrasion versus fluoride varnish in management of dentin hypersensitivity

Conditions: Hypersensitivity Dentin; Tooth Hypersensitivity

Summary: will the use of bioactive glass with air abrasion technology (sylc) compared to fluoride varnish (biflourid 10) affects the degree of pain in patients complaining from hypersensitivity due to non-carious lesions?

* population: patients complaining from dentin hypersensitivity due to non-carious lesions. * intervention: sylc, air abrasion bioactive glass (denfotex research ltd.) * comparison: biflourid 10, fluoride varnish (voco, germany) * outcome measures: dentin hypersensitivity outcome name measuring device measuring unit dentin hypersensitivity * thermal * tactile * evaporative

Eligibility criteria:
inclusion criteria: * males or females. * age: 18-70 years old. * patients with good oral hygiene. * co-operative patients who show interest to participate in the study. exclusion criteria: * patients with bad oral hygiene. * patients with orthodontic appliances, or bridge work that might interfere with evaluation. * patients who did any periodontal surgeries within the previous 6 months. * patients who are allergic to any ingredients will be used in the study. * pregnant and lactating women.

Keywords: bifluoride, sylc, hypersensitivity,
radio frequency (rf) device for reduction in size of localized areas of the body

Conditions: Cellulite

Summary: the purpose of this study is to evaluate the cutera radio frequency (rf) device for the new indication of reduction in size of localized areas of the body.

the purpose of this study is to evaluate the cutera radio frequency device for the new indication of reduction in size of localized areas of the body, including, but not limited to, areas on the abdomen, leg, and arm. at investigator's discretion, each subject will receive up to three treatments and will be scheduled for two follow-up visits after the final treatment. the treated area will be measured and photographed ar each visit for analysis. subjects will also be weighted at each visit and asked to fill out a survey during follow-up visits.

Eligibility criteria:
inclusion criteria: * female or male * minimum age of 18 years * non-smoking for at least 3 months and willing to refrain from smoking for the duration of the study. * post-menopausal, or on birth control with no plans to become pregnant for the duration of the study (female only) * minimum body mass index of 20 * visible fat in the area to be treated area to be treated to measure at least 20.0mm in vertical fold, as measured with industry standard fat caliper * subject must be able to read, understand and sign the consent form * subject must adhere to the follow-up schedule and study instructions * subject must adhere to the same diet and/or exercise routine throughout the study, and agree to maintain the same weight throughout the study (within 6 lbs of initial weight) exclusion criteria: * significant weight fluctuation (+/-10 lbs) in the past 6 months * taking weight-loss medications/supplements * participation in any other clinical study * cellulite treatment within 3 months of the treatment * surgical or non-surgical treatments to the target area in the last 12 months, e.g., liposuction * prior treatment to the target area within the last 12 months * arteriosclerosis or weakened blood vessels * heart disease * thromboembolic disease * diagnosed or documented immune system disorders * bleeding disorders. * presence of uncontrolled hypertension * taking prescription anticoagulants * history of keloid formation * malignant tumors in the target area * diabetes * any disease or condition that could impair wound healing * skin abnormalities in the target area, e.g., cuts, scrapes, wounds, scars, large moles * infection in the target area * implanted electrical device(s) * pregnant or lactating

Keywords: cellulite adipose tissue circumference reduction thigh abdomen flank
evaluating the bacterial and fungal microbiome in patients with calcium oxalate urolithiasis and renal cell carcinoma

Conditions: Calcium Oxalate Urolithiasis; Renal Cell Carcinoma

Summary: the purpose of the study is to identify bacterial and fungal microbiome associated with calcium oxalate (co) urolithiasis and renal cell carcinoma (rcc).


Eligibility criteria:
inclusion criteria: * adults that are able to consent (≥ 18 years of age) * no history of asymptomatic bacteriuria or urinary tract infection within the past 1 month * no history of coagulopathy and not on anticoagulant or antiplatelet medication at the time of surgery. * for patients with urolithiasis, must not have a history of rcc * for patients with rcc, must not have a history of urolithiasis * controls must have no history of stones, rcc, or urinary tract infection (within 1 month). * for all participants, no antimicrobial treatment within the past month exclusion criteria: * adults unable to consent * for patients with urolithiasis, technical difficulty in taking renal papillae biopsy. * history of urinary tract infection within the past 1 month * history of coagulopathy and on anticoagulants or antiplatelets that could not be stopped perioperatively. * patients with nephrolithiasis and renal tumors with positive preoperative urine cultures- suggesting asymptomatic bacteriuria. * for patients with urolithiasis, a history of rcc * for patients with rcc, a history of urolithiasis * controls who have a history of stones, rcc, or urinary tract infection. * for all participants, antimicrobial treatment within the past month.

Keywords: calcium oxalate stones renal cell carcinoma microbiome urinary microbiome
pharmacogenetic-guided choice of post-surgery analgesics

Conditions: Acute Pain; Post Operative Pain

Summary: pharmacogenomics (pgx) is the study of how genes affect a person's response to drugs. pgx testing for certain genes can help predict the risk of side effects or therapeutic failure from analgesics. testing is not regularly performed in clinical practice due to long wait times for results and challenges with integrating test results in the electronic health record. investigators leading this study hope to find out if providing surgeons with the ability to order a pgx test and electronically receive results with dosing recommendations will increase the use of these tests to guide analgesic choice and improve patient outcomes. this is a prospective, two-arm randomized implementation study. eligible participants will be randomly assigned to receive genotype-guided analgesic selection (intervention arm) or usual care (control arm). both cohorts will undergo pharmacogenetic testing at the time of consenting. the investigators will primarily measure the feasibility of using this test to guide analgesic selection.


Eligibility criteria:
inclusion criteria: 1. able and willing to provide informed consent 2. assigned female at birth and aged 18 years or older at the time of study initiation 3. major gynecologic surgery indicated and planned for hysterectomy, myomectomy, exploratory laparotomy, and open abdominal surgery 4. willing to provide a buccal swab for pgx testing and comply with all study-related procedures exclusion criteria: 1. receiving chronic opioid therapy defined as ≥ 3 consecutive months of 1-month prescriptions for an opioid 2. pregnancy 3. breastfeeding 4. treating physician does not want subject to participate