Kornimate/medical-research-clean huggingface dataset:
frequency of cognitive dysfunction in patients with chronic low back pain

Conditions: Cognitive Dysfunction; Low Back Pain

Summary: this study evaluates cognitive dysfunction status and related factors in patients with chronic low back pain over the age of 60.

the study was designed as prospective, cross-sectional and hospital-based. 55 consecutive patients over the age of 60, diagnosed with cbp, who have been suffering from low back pain for at least 6 months, and a similar number of healthy volunteers (control) in terms of age and gender, who applied to the physical medicine and rehabilitation outpatient clinic of konya beyhekim training and research hospital, will be included in the study. patients will be included in this cross-sectional, survey-type research after their compliance with the inclusion criteria is meticulously determined as a result of anamnesis and physical examination. detailed histories of all participants will be taken and detailed physical examinations will be performed. sociodemographic and clinical characteristics of the participants, such as age, gender, height, weight, educational status, marriage status, duration of illness, and employment status, will be recorded. patients will be asked some survey-type questions in a decent environment. patients' pain and fatigue levels were measured by the visual pain scale (vas), their emotional states by the beck depression scale (bdi) and pain catastrophizing scale, their functional disability level by the roland morris disability questionnaire, and their sleep quality by the single likert type question in the pittsburgh questionnaire. quality of life will be evaluated with short form-36 (sf-36), and their cognitive status will be evaluated with standard mini mental test (smmt) and montreal cognitive assessment scale (moca).moca, mini mental test and mood tests are administered by a professional psychologist experienced in the application of these scales.

Eligibility criteria:
inclusion criteria: being over 60 years old having a history of low back pain lasting more than 6 months and being diagnosed with cbp having pain of at least 3 intensity according to vas exclusion criteria: those under 60 years of age * those with neurological deficits * those with inflammatory low back pain * those with rheumatic diseases such as fibromyalgia, polymyalgia rheumatica, ankylosing spondylitis, rheumatoid arthritis * having undergone surgery in the lumbar region within the last 6 months * those with widespread pain, those with significant pain in another anatomical location (e.g. gonarthrosis) * those who use drugs or substances (alcohol, drugs, etc.) that may cause cognitive impairment * those with known neurological diseases such as cerebrovascular disease, ms, parkinson's, dementia * those with major psychiatric illness * those with communication problems * those who have started psychiatric medical treatment within the last three months * those with significant hearing or vision problems * those with a history of uncontrolled systemic disease (cardiovascular, pulmonary, hepatic, renal, hematological, endocrine, etc.)

Keywords: cognitive dysfunction low back pain chronic pain
a study of herceptin (trastuzumab) combination therapy in patients with metastatic urothelial cancer

Conditions: Urinary Tract Cancer

Summary: this study will evaluate the efficacy and safety of a chemotherapy regimen of intravenous herceptin, cisplatin and gemcitabine in patients with metastatic urothelial cancer. the anticipated time on study treatment is until disease progression.


Eligibility criteria:
inclusion criteria: * adult patients with \>=18 years of age; * metastatic urothelial carcinoma; * measurable metastases or local recurrent disease; * no prior chemotherapy for metastatic disease; * her2 overexpression (ihc \[2+\] or \[3+\]). exclusion criteria: * concomitant chemotherapy or immunotherapy; * active or uncontrolled infection; * solely cns metastases; * clinically significant cardiac disease, advanced pulmonary disease or severe dyspnoea; * co-existing malignancies diagnosed within last 5 years, except basal cell cancer or cervical cancer in situ.
immune treatment of brain metastasis of lung cancer combined with large-segmentation precision radiotherapy

Conditions: Non Small Cell Lung Cancer

Summary: this is a prospective multicenter clinical study. this study aims to construct an auxiliary decision-making system for lung cancer immunotherapy combined with radiotherapy by fusing three modes of imagomics, clinicopathological features, and molecular pathological features.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years of age on day of signing informed consent * histopathology confirmed non-small cell lung cancer * asymptomatic brain metastases * egfr/alk ros1 driver gene mutation negative * recist 1.1 based available assessment of lesions * ecog 0-1 * brain metastases 1-4 * single lesion ≤4cm exclusion criteria: * patients with contraindication of chemotherapy pregnant or breast feeding women
cognitive training for patients with eating disorders

Conditions: Feeding and Eating Disorders; Anorexia Nervosa; Bulimia Nervosa; Binge-Eating Disorder

Summary: eating disorders are severe mental illnesses, mainly affecting adolescent- and young adult women. the prognoses for eating disorders are relatively poor, and a large part of patients with these illnesses do not benefit from available conventional therapies. after decades of research into the causes of eating disorders, there is now compelling evidence for specific neuropsychological difficulties in patients affected by eating disorders. these neuropsychological difficulties are characterized by cognitive and behavioral rigidity (poor set-shifting abilities), as well as difficulties related to central coherence, planning and impulse control. surprisingly, few therapies specifically target these difficulties, and they are rarely incorporated into treatment. cognitive remediation therapy has shown promising results as an adjunctive therapeutic intervention for patients with anorexia nervosa. the primary aim of this randomized controlled trial is thus to investigate the effect of cognitive remediation therapy on neuropsychological function, symptoms of eating disorders and general mental health, quality of life and motor activity in women with both eating disorders (transdiagnostic) and these specific cognitive difficulties.


Eligibility criteria:
inclusion criteria: * being in in-patient-, day- or out-patient treatment for an eating disorder (anorexia nervosa, bulimia nervosa, binge eating disorder or osfed) * displaying cognitive difficulties (score ≤ -1 standard deviation) on: 1. the inhibit, shift, plan/ organize and/ or global executive composite indexes of the self-report measure the brief-a (reversed) 2. the total errors, perseverative responses, perseverative errors and/ or learning to learn from the wisconsin card sorting test (wcst) and/ or on the rey complex figure test (rcft) copy condition or q-score and/ or on condition 3 and 4 on the color-word interference test from (d-kefs) * being able to understand and speak norwegian * be willing to provide written informed consent * accepting random allocation to the two arms of the study exclusion criteria: * a history of congenital or acquired brain injury (except concussions) * active substance abuse * psychosis * intelligence quotient (iq) less than 70

Keywords: cognitive remediation neuropsychology neuropsychological tests
a prospective clinical study of a cohort of patients seeking treatment for a behavioral addiction

Conditions: Behavioral Addictions

Summary: this research aims to provide a better understanding of the factors associated with the evolution of behavioral addictions, and compliance with care. the investigators thus aim to follow patients with several types of behavioral addictions, based on addictive, sociodemographic, clinical and endophenotypical characteristics, as well as their care adhesion.


Eligibility criteria:
inclusion criteria : - all consecutive patients seeking treatment at the university hospital of nantes for a behavioral addiction and age over 15 will be allowed to participate to the study. exclusion criteria : * cognitive impairment incompatible with the assessment * difficulty for writing or reading the french language, incompatible with the assessement * gardianship

Keywords: cohort cognitive distortions impulsivity psychiatric comorbidities addiction gambling disorder sexual addiction videogame disorder food addiction eating disorders compulsive buying behavioral addictions
efficacy and safety of azithromycin in patients with bronchiolitis obliterans

Conditions: Bronchiolitis Obliterans

Summary: placebo-controlled, double-blind, randomized study. post-infectious bronchiolitis obliterans (pibo) patients aged 5 years and older of both sexes were enrolled.

bronchiolitis obliterans (bo) was defined as the presence of signs and symptoms of chronic obstructive lung disease: a) previously documented acute lower respiratory infection (alri) with persistence of airway obstruction and respiratory signs and symptoms, such as: dyspnea, tachypnea, retractions, persistent cough, increased antero-posterior diameter of the chest, persistent wheezing, crackles, exercise intolerance; b) findings such as: hyperinflation, atelectasis, and mosaic oligohemia on ct scan; and c) persistent obstructive pattern on pulmonary function test. patients were randomly assigned by pharmacy staff in blocks of 4 to receive either capsules of azithromycin 250 mg (group 1) or placebo (group 2) 3 days a week for 6 months. patients whose weight was less than 40 kg received 250 mg 3 days a week (monday, wednesday, and friday) and those weighing more than 40 kg received 500 mg in the same scheme, according to randomization to active drug or placebo. pulmonary function and number of exacerbations were evaluated. spirometry and plethysmography were performed at baseline and at 6 months. variables analyzed were forced vital capacity (fvc),flow expiratory volume at the first second (fev1), total lung capacity (tlc),residual volumen(rv),especific conductance (sgaw). patients had been clinically stable over the previous three weeks.

Eligibility criteria:
inclusion criteria: * patients with diagnosis of bronchiolitis obliternas * older than 5 years * ability to perform pulmonary function test exclusion criteria: * not being able to perform lung function study adequately * other causes of chronic lung disease (bronchopulmonary dysplasia, cystic fibrosis, primary or secondary immune deficiency) * previous history of portal hypertension, liver cirrhosis, splenomegaly or chang in normal values of laboratory at the start of the study. * history of hypersensitivity to macrolides

Keywords: bronchiolitis obliterans azithromycin
a study to evaluate the pharmacokinetics and the effect on cardiac repolarization of odalasvir administered as a single dose tablet under fed conditions in healthy participants

Conditions: Healthy

Summary: the purpose of this study is to determine the relationship between the plasma concentrations of odalasvir and changes in the qt interval / qtc interval (qt corrected for heart rate) using exposure-response (er) analysis.


Eligibility criteria:
inclusion criteria: * participant must sign an informed consent form (icf) indicating that he or she understands the purpose of, and procedures required for, the study and is willing to participate in the study * participant must be willing and able to adhere to the prohibitions and restrictions specified in this protocol * participant must be healthy on the basis of physical examination, medical history, and vital signs performed at screening * participant must have a blood pressure (after the participant is supine for 5 minutes) between 90 and 140 millimeter of mercury (mmhg) systolic, inclusive, and no higher than 90 mmhg diastolic * participant must have normal 12-lead electrocardiogram (ecg) and echocardiogram and must be healthy on the basis of clinical laboratory tests performed at screening * participant must be nonsmoker for at least 6 months prior to study drug administration exclusion criteria: * participant with a history of clinically relevant heart rhythm disturbances including atrial, junctional, re-entry, and ventricular tachycardia, and heart blocks * participant with unusual t wave morphology (such as bifid t wave) likely to interfere with qtc measurements * participant with a past history of: sick sinus syndrome, cardiac arrhythmia (example, extrasystolic rhythms or tachycardia at rest). isolated extrasystolic beats are not exclusionary, risk factors associated with torsade de pointes (tdp) such as hypokalemia, family history of short/long qt syndrome, sudden unexplained death (including sudden infant death syndrome) in a first-degree relative (that is, sibling, offspring, or biological parent) * participant with any skin condition likely to interfere with ecg electrode placement or adhesion * participant with a breast implant or a history of thoracic surgery likely to cause abnormality of the electrical conduction through thoracic tissues * participant with any history of clinically significant skin disease such as, but not limited to, dermatitis, eczema, drug rash, psoriasis, food allergy, or urticaria * participant has received an investigational drug (including investigational vaccines) or used an invasive investigational medical device within 30 days or within a period less than 10 times the drug's half-life, whichever is longer, before the planned administration of study drug, or is currently enrolled in an investigational study * participant has a history of human immunodeficiency virus (hiv)-1 or hiv-2 infection positive, or tests positive for hiv-1 or hiv-2 at screening
physician clinical trial policy (ctp) neurological ischemia lower extremity pain and swelling

Conditions: Lower Extremity Swelling Acute

Summary: physician clinical trial policy (ctp) to evaluate the efficacy treatment of lower extremity pathologies derived from neurological ischemia disorders using the combination of monochromatic infrared photo energy (mire) and transcutaneous electrical nerve stimulation (tens) therapies.

although there are a number of pain disorders, associated with back, or lower extremity pain and swelling, the american association of sensory electrodiagnostic medicine (aasem/ dtsc) study programs will accumulate received data following a protocol of treatment performed for the purpose of eliminating pain, reducing swelling, and accelerating recovery periods as well as to record the success or failure and/or improvement of the malfunctioning body part. * condition: neuropathic pain, tingling or numbness derived from neurological ischemia * intervention: treatments of monochromatic infrared photo energy (mire) in combination with electronic signal treatment (tens) therapy * study type: interventional * study design: 1. allocation: non-randomized 2. endpoint classification: efficacy study 3. intervention model: single group assignment 4. masking: open label 5. primary purpose: scientific record of treatment success or failure

Eligibility criteria:
inclusion criteria: * in the investigator's judgment, a high probability of 5 year survival and compliance with the study visit schedule. ability to comprehend and sign an informed consent document prior to study enrollment. exclusion criteria: * any other excluding factors that, according to the investigator's judgment, would preclude enrollment in the study.
missed serious medical illness in psychiatric patients seen in an academic emergency department

Conditions: Emergency Services, Psychiatric

Summary: psychiatric presentations are common in the emergency department (ed), and determining whether or not a psychiatric presentation is due to medical illness can be a difficult task for the emergency physician. the investigators define "serious medical illness" (smi) as a pathological condition that would necessitate inpatient treatment on a medical or surgical ward. it is important for patient safety that smi be triaged by the emergency physician to the appropriate inpatient service. the rate of missed smi in patients with psychiatric presentations to the ed is unknown. the investigators will research missed smi in patients referred to adult psychiatry from the ed, with the intent to improve patient safety.


Eligibility criteria:
inclusion criteria: * all patients greater than or equal to 18 years of age presenting to london health sciences centre, victoria hospital emergency department between october 1, 2014 - july 31, 2015 who were referred to adult psychiatry by the emergency physician. exclusion criteria: * none
lung ultrasonography after laparoscopic gynecologic surgery

Conditions: Pulmonary Atelectasis

Summary: this study evaluates the influence of surgical and anesthesia-related variable on atelectasis formation during laparoscopic gynecologic oncologic surgery by lung ultrasound.

approximately 50% of patients undergoing general anesthesia are hypoxemic. anaesthesia, paralysis, high concentrations of oxygen, inadequate level of peep, capnoperitoneum, trendelenburg position all result in persistent atelectasis. lung ultrasound is a safe and accurate bedside tool useful to study lung aeration. the aim of the investigator's study was to assess the impact of general anesthesia and laparoscopic gynecologic oncologic surgery on post-operative atelectasis and related oxygenation changes using lung ultrasound.

Eligibility criteria:
inclusion criteria: * patients older than 18 yo undergoing laparoscopic surgery for gynecologic surgery who provide written informed consent. exclusion criteria: * age \< 18 yo; * pregnancy; * refused to partecipate; * known pulmonary metastasis; * preexisting pulmonary conditions (copd, pleural effusion, pulmonary consolidations, lung edema, pulmonary embolism); * anesthesia with mechanical ventilation in the 2 weeks.

Keywords: pulmonary atelectasis lung ultrasound laparoscopic surgery
changes in metabolic status in patients with total thyroidectomy

Conditions: Thyroid Cancer

Summary: this study objective is to evaluate the change in mitochondrial uncoupling protein 2 (ucp2) mrna expression as function of thyroid activity (tsh, t3 and free t4).

blood will be drown before thyroidectomy, 2 weeks after the operation and 3-4 month after the operation.

Eligibility criteria:
inclusion criteria: * patients who were diagnosed with thyroid carcinoma and are going to have total thyroidectomy. * patients with unbalanced thyroid hormones. * aged 18-65 years at the time of screening. * provision of written informed consent. exclusion criteria: * patients with diabetes. * patients with any other chronic inflammatory diseases. * steroid treatment.

Keywords: ucp2 thyroid function thyroid carcinoma
comparative efficacy of laser, extracorporeal shockwave therapy and exercise therapy on plantar fasciitis outcomes

Conditions: Plantar Fascitis

Summary: this study aims to evaluate the effectiveness of exercise combined with eswt (extracorporeal shockwave therapy), exercise combined with mls (multiwave locked system) laser therapy, and exercise alone in female patients diagnosed with unilateral plantar fasciitis, using visual analog scale (vas), heel tenderness index (hti), foot and ankle outcome score (faos), foot function index (ffi) and fall risk, as clinical parameters to assess any differences in effectiveness levels among these treatments.

plantar fasciitis (pf) is a prevalent condition characterized by the degeneration of the plantar fascia, a band of connective tissue that originates from the calcaneus to the proximal phalanges and the skin of the foot's anterior part. despite common misconceptions, plantar fasciitis is not primarily an inflammatory process but results from repetitive microtears leading to a secondary inflammatory reaction of the plantar fascia. despite the condition's self-limiting nature, with 70% to 80% of patients experiencing symptom relief through conservative treatment alone, a combination of treatments is often necessary for many. conservative interventions include rest, cold application, stretching and strengthening exercises, orthotic devices, lifestyle modifications, weight loss, and night splints. additionally, non-invasive physical therapy modalities such as extracorporeal shock wave therapy (eswt), laser, and ultrasound have shown to be cost-effective and accessible treatment options. invasive treatments, including injections and surgery, are considered for resistant cases previous studies have examined the effectiveness of eswt, low level laser therapy, high intensity laser therapy, and exercise treatments in patients with pf, demonstrating their efficacy. although there are studies investigating the effectiveness of mls laser therapy on various musculoskeletal pathologies, to our knowledge, there is no study specifically examining its efficacy on pf

Eligibility criteria:
inclusion criteria: * age between 18-65 years * female gender * symptoms persisting for at least 6 weeks * unilateral plantar fasciitis * consent to participate in the study exclusion criteria: * male gender * bilateral plantar fasciitis * treatment with eswt, laser or injection therapy for plantar fasciitis in the previous year * participation in a physical therapy program for plantar fasciitis in the last six months * history of systemic inflammatory disease * history of lower extremity fracture or surgery * pregnancy * history of epilepsy * malignancy * active infection * coagulation disorders * severe cardiac disease or history of pacemaker * history of neuromuscular disease affecting balance parameters * regular use of nonsteroidal antiinflammatory drugs

Keywords: plantar fasciitis exercise lasers extracorporeal shockwave therapy
a trial investigating the effect of probenecid and ciclosporin on the concentrations of snac in healthy subjects

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: the aim of the study is to investigate the effect of the medicines, probenecid and ciclosporin on the concentrations of snac. snac is an ingredient of the semaglutide tablets. participants will get 3 different treatments (that is 3 treatment periods): 1) a single dose of 3 mg semaglutide, 2) a single dose of 600 mg ciclosporin with 3 mg semaglutide, 3) 500 mg probenecid twice a day for 3 ½ days with a single dose of 3 mg semaglutide on the last day. the sequence of treatments participants get is decided by chance. probenecid and ciclosporin are available medicines. they are given by doctors. semaglutide contains snac. it cannot be prescribed yet. the study will last for up to 125 days. participants will have 17 to 18 visits at the study centre. this includes short visits at the centre for blood sampling only. participants will have several blood draws.


Eligibility criteria:
inclusion criteria: * male or female of non-childbearing potential, aged 18-64 years (both inclusive) at the time of signing informed consent. * body mass index between 18.5 and 29.9 kg/sqm (both inclusive). * body weight greater than or equal to 50.0 kg. * considered to be generally healthy based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator. exclusion criteria: - use of tobacco and nicotine products, defined as: a. smoking more than 1 cigarette or the equivalent per day b. not able or willing to refrain from smoking and use of nicotine substitute products during the in-house period(s). * presence of clinically significant gastrointestinal disorders or symptoms of gastrointestinal disorders potentially affecting absorption of drugs or nutrients, as judged by the investigator. * history (as declared by the subject) of major surgical procedures involving the stomach potentially affecting absorption of trial products (e.g. subtotal and total gastrectomy, sleeve gastrectomy, gastric bypass surgery). * known glucose-6-phosphate-dehydrogenase deficiency (as declared by the subject).