Kornimate/medical-research-clean huggingface dataset:
prone position for nonintubated patients with covid-19 and hypoxemic respiratory failure

Conditions: Covid19; Ards; Respiratory Failure

Summary: the aim of this observational study is to evaluate the physiological and clinical effects of prone position in awake patients with respiratory failure due to covid-19.

the purpose of this study is to investigate the role of prone positioning in sars-cov-2 infected patients that are not intubated. prone patient placement during invasive mechanical ventilation is a widespread practice in the management of severe ards. however, few attempts have been made to implement the prone position in patients that spontaneously ventilate with supplemental oxygen. considering that it is a procedure that does not require additional equipment and does not represent an additional cost for its implementation, it becomes a valuable tool in the context of covid-19 where intubation is associated with high mortality. the investigators will analyze a cohort of patients with covid-19 and respiratory failure managed with prone position as indicated by the attending physician and register physiological variables and clinical outcomes (intubation and death).

Eligibility criteria:
inclusion criteria: * hospitalized patients with confirmed or suspected covid-19 pneumonia requiring more than 3 liters per minute of supplemental oxygen or a fraction of inspired oxygen (fio2) over 35% to keep pulse oximetry saturation (spo2) over 90% * treating physician indicated prone position as instructed by the institutional protocol * patient capable of changing position with minimal help from the personnel exclusion criteria: * patient requiring immediate intubation * patient requiring non-invasive mechanical ventilation * respiratory rate \> 40, signs of respiratory fatigue or unconsciousness with inability to protect the airway * paco2 \> 50mmhg * hemodynamic instability (defined by heart rate \> 120, systolic pressure \< 90mmhg, mean arterial pressure \< 60mmhg or requiring vasopressor support) * obesity with bmi \> 40 (body mass index: weight in kilograms and height in meters will be combined to attain bmi in kg/m2) * persistent vomiting * facial or thoracic trauma or recent surgery contraindicating the prone position * pregnancy \> 20 weeks
long-term follow-up of hiv subjects exposed to sb-728-t or sb-728mr-t

Conditions: HIV-1-infection

Summary: long-term follow-up of hiv-infected subjects who received sb-728-t or sb-728mr-t. enrolling subjects will be followed for a total of 12 years.

subjects infected with hiv who have received therapy with sb-728-t or sb-728mr-t will be eligible to participate in this trial. there will be no treatment in this long-term follow-up study. subjects who choose to enroll into this extension study will be evaluated for a total of 12 years.

Eligibility criteria:
inclusion criteria: subjects who have, in previous sangamo clinical trial received sb-728-t or sb-728mr-t, autologous t-cells genetically modified at the ccr5 gene by zinc finger nucleases and give consent to participate in the long-term follow-up study. exclusion criteria: there are no exclusion criteria for this study.

Keywords: hiv gene editing ccr5
mr spectroscopy as a diagnostic and outcome measure in pain and sci

Conditions: Spinal Cord Injury; Hyperalgesia, Secondary; Hyperalgesic Sensations

Summary: the goal of this study is to compare the changes that occur in sensation and chemical properties of the brain following sci between individuals that experience chronic pain and those that do not, and between those with sci and the able-bodied.

this study investigates the differences in certain neurochemicals present in areas of the brain linked to pain processing in people with sci and neuropathic pain, in people with sci but no pain, and in able-bodied persons. we will also investigate the relationship between these concentrations of neurochemicals and different aspects of chronic neuropathic pain, including the intensity of pain, quality of life issues, sensitivity changes in areas of the body that are both painful and non-painful, and neurological status.

Eligibility criteria:
inclusion criteria: 1. sci and neuropathic pain: * fluent in english * incomplete or complete traumatic sci * the injury must have occurred at least 2 years prior to entering the study * the injury level must be above l1 and the subjects must have evidence of preserved distal cord functions (lower extremity reflexes and bulbocavernosus or anal wink reflexes) * must have experienced chronic neuropathic pain at or below the level of injury for a minimum of six months * must have moderately severe or greater neuropathic pain * must be able to attend three sessions ranging from 2 to 6 hours over a period of 4 to 5 weeks 2. sci and no neuropathic pain: - same as a., but participants in this group must not have unremitting moderate-severe pain and there will only be two sessions ranging from 2 to 6 hours over a period of 1 to 2 weeks 3. able-bodied control subjects: * fluent in english * no history of chronic pain conditions * no substantial brain or body injury * must be able to attend two sessions ranging from 2 to 6 hours over a period of 1 to 2 weeks exclusion criteria: * current pregnancy or women who are contemplating pregnancy * recent (one-year) history of alcohol or drug abuse * known intra-cerebral pathology or epilepsy * mri findings indicative of intra-cerebral pathology * significant post-traumatic encephalopathy from head trauma sustained at sci or cognitive impairment indicative of traumatic brain injury * current diagnosis of dsm-iv axis i disorder * inability to meet the mri screening requirements (including, but not limited to, the presence of a pacemaker or other electronic devices, prosthesis, artificial limb or joint, shunt, some metal rods, some tattoos, or moderate to severe claustrophobia or anxiety)

Keywords: spinal cord injury pain chronic neuropathic pain sci pain pain, chronic neuropathic spectroscopy, magnetic resonance mrs traumatic brain injury pain
short-term air pollution exposure and in-hospital outcomes in patients with acute myocardial infraction

Conditions: Air Pollution; Acute Myocardial Infarction; Percutaneous Coronary Intervention

Summary: the aim of this study is to investigate whether or not short-term expose to air pollution is associated with in-hospital outcomes, such as mortality and morbidity.


Eligibility criteria:
inclusion criteria: * less than 12 hours after the onset of myocardial infarction symptoms * documented acute st (s- and t-wave)-segment elevation myocardial infarction * received emergent percutaneous coronary intervention exclusion criteria: * age under 18-year old
study of enzyme supplements to treat celiac disease

Conditions: Celiac Disease; Dermatitis Herpetiformis

Summary: the purpose of this study is to examine whether a cocktail of two common food-grade enzyme supplements leads to decrease of serum activity markers in celiac disease patients insufficiently treated by previous gluten exclusion.

celiac disease is genetically determined abnormal immune response to gluten, a component of wheat, rye and barley proteins that cause damage to the villous structure in the small bowel. the active disease is characterized by the induction of gluten-dependent autoantibodies to transglutaminase type-2, which are sensitive and specific non-invasive markers of gluten-sensitivity. gluten-free diet normally leads to clearance of antibodies from serum in 6-12 months. persistent seropositivity is a problem in patients who only incompletely exclude gluten or frequently transgress the diet. in such cases, damage of the small bowel may persist and complications may occur at higher frequency. the central hypothesis to be tested is that enzyme treatment designed to degrade a certain amount of gluten before absorption in the gastrointestinal tract will lead to a clinically meaningful decrease in auto-antibody levels in these patients.

Eligibility criteria:
inclusion criteria: * celiac disease diagnosed by small intestinal biopsy * more than 12 months elapsed since initial diagnosis and start of the dietary treatment * evidence for ongoing active disease as verified by seropositivity or dermatitis herpetiformis rash * subject agrees to follow a gluten-free diet exclusion criteria: * other gastrointestinal or hepatic disease besides celiac disease * selective iga deficiency * use of dapsone or diaphenylsulfone * pregnancy and breast-feeding

Keywords: celiac disease transglutaminase antibody
anhidrotic area and safety of meditoxin in healthy male valunteers

Conditions: Anhidrotic Area; Hyperhidrosis

Summary: to determine the anhidrotic area and safety of meditoxin


Eligibility criteria:
inclusion criteria: * male adults aged between 20 and 45 years exclusion criteria: * subjects not appropriate for participating in this study according to the investigator's opinion
the paths descriptive correlational longitudinal study

Conditions: Single-ventricle; Posttraumatic Stress Disorder; Psychosocial Impairment

Summary: the primary objective of this study is to measure parent's post-traumatic stress before and after their infant's second palliative heart surgery for single ventricle congenital heart disease. the investigators will use the posttraumatic stress disorder checklist for the dsm-v (pcl-5) to measure levels 2-4 weeks before and after the infant's second heart surgery. the investigators aim to describe the levels at the two-time points, compare the scores, and identify demographic information that correlates with the scores.


Eligibility criteria:
inclusion criteria: * parent who is 18 years or older of an infant with svchd * following with champ through children's mercy hospital. any person personally identifying as a parent of the child, who lives in the same household as the infant, and who will provide primary care after discharge from the hospital is eligible to participate. exclusion criteria: * parents of an svchd infant who is undergoing end-of-life care, determined by the primary care team.

Keywords: remote monitoring nursing parents transition
postoperative outcomes of trans-abdominal open surgical repair of traumatic diaphragmatic hernias in adults.

Conditions: Hernia, Diaphragmatic

Summary: objective: evaluation of our management of acute or chronic traumatic diaphragmatic hernia repair with sutures or mesh. between january 2014 and january 2019, a retrospective study on 185 patients with acute and chronic traumatic diaphragmatic hernias was carried out at the general surgery department of zagazig university. results both during and after surgery were assessed.

traumatic diaphragmatic hernias are the outcome of 0.8% to 6% of blunt trauma cases and more than 17% of cases involving thoraco-abdominal-penetrating trauma (tdh) . chronic traumatic diaphragmatic herniation (ctdh) is a condition that can develop as a result of an enlargement of a defect in the diaphragm brought on by a pressure difference between the thoracic cavity and the abdominal cavity . it is possible that the rupture will not heal on its own due to the inherent pressure difference that exists between the thorax and the abdomen as well as the continuous movement of the diaphragm . due to the seriousness of the related organs' injuries, traumatic diaphragmatic rupture presents a complex emergency and typically necessitates a high diagnostic suspicion. the herniated structures may strangulate into the thoracic cavity, and the mortality rate may increase considerably if the traumatic diaphragmatic hernia is not identified and treated in the acute phase of the trauma . these patients may not be diagnosed until weeks, months, or even years after the initial traumatic event, and they may present with acute symptoms related to the cardiovascular system and the digestive tract. a high mortality rate is seen in people with ctdh with viscera that have been strangulated. despite advancements in diagnostic technologies, 2.7 - 50% of patients still have a misdiagnosis . early, accurate diagnosis is now more common thanks to greater experience and the emergence of imaging tools, particularly computed tomography (ct). a limited number of researches describe acute and chronic traumatic diaphragmatic hernias in terms of intraoperative and postoperative outcomes. to examine the intraoperative and postoperative results of patients with traumatic diaphragmatic hernias repaired using either suture repair or mesh repair in terms of morbidity, mortality rate, and incidence of recurrence, the investigators have established a retrospective cohort analysis for the current investigation.

Eligibility criteria:
inclusion criteria: * \>18 years old, male or female, and had an acute or chronic traumatic diaphragmatic hernia exclusion criteria: * hiatus hernias, congenital hernias, diaphragmatic tears without herniation of abdominal organs, eventration of the diaphragm, hernias on both sides of the diaphragm, and recurrent diaphragmatic hernia after prior repair
bipolar disorder in epilepsy

Conditions: Epilepsy; Bipolar Disorder

Summary: the purpose of this study is to find out how often major mood swings occur in patients treated in a specialty epilepsy center.

bipolar disorder (a condition of major mood swings) or milder forms of ups and downs in mood may occur with a number to neurological conditions. recently, one study showed that these mood changes occur fairly often in individuals with epilepsy studied in the general community. we speculate that bipolar symptoms occur with even higher frequency in a tertiary epilepsy center than that encountered in the previous community-based study. the goals of this study are to assess: * the rate of bipolar symptoms as measured by a self-reporting screening tool in a tertiary epilepsy center setting * the meaning of a positive screening score in epilepsy patients * the utility, sensitivity and specificity of alternative screening tools for mood instability in epilepsy patients * the correlation of mood instability with seizure-related variables * the relation of a positive screening score on quality of life.

Eligibility criteria:
inclusion criteria: * male or female 18 years of age or older * being evaluated at the long island jewish comprehensive epilepsy center * capable of completing self-reporting questionnaires exclusion criteria: * patients with mental retardation * patients with pseudoseizures

Keywords: epilepsy bipolar disorder
surgical treatment of mandibular furcations using a xenograft with/without a collagen membrane

Conditions: Furcation Defects

Summary: the aim of the study was to perform a randomized controlled clinical study in order to compare the effects of a bovine derived xenograft (with 10% collagen) + a bioabsorbable membrane (control group, cg) vs a bovine derived xenograft (with 10% collagen) alone (test group, tg) on the surgical treatment of mandibular type ii furcation defects.

the aim of the study was to perform a randomized controlled clinical study in order to compare the effects of a bovine derived xenograft (with 10% collagen) + a bioabsorbable membrane (control group, cg) vs a bovine derived xenograft (with 10% collagen) alone (test group, tg) on the surgical treatment of mandibular type ii furcation defects. the patients all underwent the same surgical intervention with the only difference between the two groups being the use or not of a collagen membrane.

Eligibility criteria:
inclusion criteria: * patients diagnosed with chronic periodontitis * initial phase (oral hygiene instructions + full mouth scaling and root planing) performed at least eight weeks before inclusion * full-mouth plaque score ≦ 20% (at least eight weeks after initial phase and during the whole treatment) * clinical evidence of vestibular or lingual mandibular class ii furcation defects (≧ 3mm of horizontal probing depth) * presence of at least 2 mm of keratinized gingiva on the selected tooth surface facing the furcation * tooth vitality confirmed by clinical tests (cold testing) exclusion criteria: * presence of any systemic disease * smokers * devitalized tooth or tooth presenting periapical or pulpar pathology (confirmed with a retro-alveolar radiograph) * allergies to any of the products used in the present study * pregnant or breastfeeding women * history or current rx therapy

Keywords: mandibular type ii furcations periodontal treatment demineralized bovine bone mineral collagen membrane
safety of intranasal fentanyl (pecfent®) in the treatment of procedural pain in the elderly

Conditions: Pain Due to Certain Specified Procedures

Summary: the purpose of this study is to evaluate the safety of the intranasal fentanyl in pain induced by wound care and rehabilitation in the elderly. the project would also provide a preliminary assessment of the effectiveness of intranasal fentanyl used in procedural pains.

this is a safety clinical trial. this trial is monocentric, open label, non-randomized. sixty elderly patients will be enrolled in this study, 30 with bedsore cares and 30 with rehabilitation sessions. six bedsore cares or rehabilitation sessions will be assessed for each subject. for each session, patient pain will be evaluated using a visual analogic scale vas at different times, before session, 5 minutes then 20 minutes after the beginning of the session, and a last vas 1 hour after the end of the session. during the two first sessions, patients do not receive pecfent® to assess their basal pain. during the following four sessions, patients will receive transmucosal fentanyl, 10 minutes before care. an evaluation of respiratory rate and of the level of sedation will occur at different time : after 5 minutes then 20 minutes of care, at the end of the care session,at half an hour then one hour after the care session. at the end of sessions, * the nurse or physiotherapist will assess their satisfaction regarding the objectives achieved during the session with a four points verbal descriptor scale (very satisfied, satisfied, not much satisfied, not satisfied). they will also evaluate at the end of the four last session their satisfaction regarding the convenience of the use of pecfent® and its contribution towards care. * patients will assess their satisfaction regarding the course of the session with a verbal descriptor scale (vds) and their level of anxiety felt during the session with a vas.

Eligibility criteria:
inclusion criteria: * hospitalized geriatric patient requiring care or rehabilitation * patient with pain during treatment or mobilization. (vas ≥ 4) * written informed consent exclusion criteria: * all unstable fractures * confusion: unable to assess their level of pain using a vas. * contraindications to pecfent ® (. hypersensitivity to the active substance or to any of the excipients listed in section composition use in patients who had never received treatment for opioid severe respiratory depression or severe obstructive pulmonary disease.) * person under legal protection

Keywords: safety procedural pain intranasal fentanyl elderly
a clinical study to assess the physiologic effects of kb109 in patients with covid-19 on gut microbiota structure and function

Conditions: Mild-to-Moderate COVID-19

Summary: this exploratory, open-label clinical study aims to explore the physiologic effects of kb109, a novel glycan, on adult patients with covid-19 illness on gut microbiota structure and function in the outpatient setting.


Eligibility criteria:
to be considered for enrollment into this study, each patient must meet all of the following inclusion criteria: 1. be male or female, ≥18 years of age 2. be willing and able to give informed consent 3. screening/randomization telemedicine visit within 2 days of testing positive test for covid-19 4. having self-reported fever or cough for not more than 72 hours prior to covid-19 testing 5. mild to moderate covid-19 6. able to adhere to the study visit schedule and other protocol requirements patients who meet any of the following exclusion criteria at the randomization visit will not be enrolled into the study: 1. patients who are hospitalized for in-patient treatment or currently being evaluated for potential hospitalization at the time of informed consent for conditions other than covid-19 2. history of chronic lung disease 3. ongoing requirement for oxygen therapy 4. shortness of breath in resting position 5. diagnosis of sleep apnea requiring bilevel positive airway pressure (bipap) / continuous positive airway pressure (cpap) 6. female patients who are pregnant, trying to become pregnant or lactating. 7. is considered, in the opinion of the pi, to be unlikely for any reason to be able to comply with study procedures

Keywords: microbiome covid-19 corona virus corona virus disease kaleido kaleido biosciences kb109 oligosaccharides glycan outpatient pathogens microbiome metabolic therapy mmt telemedicine
scorpio non restricted geometry (nrg) study in japan

Conditions: Osteoarthritis; Rheumatoid Arthritis

Summary: the purpose of this study is to evaluate the range of motion (rom), mid-flexion stability (gap balance), and implant position (size and angle) for the scorpio nrg device. relationship between these parameters and clinical outcomes will be evaluated as well as the importance of rotational tolerance. it is expected that the scorpio nrg will have good clinical outcomes and perform the same or better than other total knee implants.


Eligibility criteria:
inclusion criteria: 1. patient who is candidate for primary total knee arthroplasty (tka). 2. patient who has diagnosis of osteoarthritis or rheumatoid arthritis. 3. patient who is age 20 or over. 4. patient who signed an institutional review board (irb)-approved, study specific informed patient consent form. 5. patient who is willing and able to comply with postoperative scheduled evaluations. exclusion criteria: 1. patient who has a bacterial infectious disease or has a risk high of a bacterial infection. 2. patient who requires revision surgery. 3. patient who is morbidly obese, defined as having a body mass index (bmi) \> 40. 4. patient who is or may be pregnant female. 5. patient who has a neuromuscular or neurosensory deficiency, which limits ability to evaluate the safety and efficacy of the device. 6. patient with diagnosed systemic disease (i.e. paget's disease, renal osteodystrophy). 7. patient who is immunologically suppressed or receiving chronic steroids. 8. patient who is judged ineligible with specific reason by primary doctor.