Kornimate/medical-research-clean huggingface dataset:
effect of erythropoietin (epo) in kidney after cardiac surgery

Conditions: Kidney Failure, Acute

Summary: the purpose of this study is to determine whether erythropoietin is effective in preventing acute kidney dysfunction after coronary artery bypass grafting surgery.

acute kidney injury (aki) occurs in 7% to 40% of patients undergoing cardiac surgery, depending on the definition of aki used. even small increments in serum creatinine have been shown to be associated with increased mortality after cardiac surgery. however, there are no proven interventions to prevent aki after cardiac surgery. erythropoietin (epo) has been shown to have tissue-protective effects in various experimental models. in this prospective placebo-controlled randomized trial, we evaluated the effectiveness of epo in the prevention of aki after coronary artery bypass grafting (cabg).

Eligibility criteria:
inclusion criteria: * patients scheduled for elective cabg over age 18 exclusion criteria: * under age 18 * emergent cabg * prior exposure to nephrotoxic drug * dialysis patients * uncontrolled hypertension
diagnostic value of arterial blood gas analysis in prehospital patients

Conditions: Unconscious (Psychology)

Summary: in the anesthesiologist-manned mobile emergency car unit an analyzing device for blood gas testing is present since 2014. this study will determine if a prehospital arterial blood gas helps the doctor to make more precise diagnosis prehospitally. furthermore it will be determined if the doctors find this device helpful in assessing and treating patients with affected consciousness.


Eligibility criteria:
inclusion criteria: * gcs \< 13 exclusion criteria: * pregnant or breastfeeding * detained or imprisoned patient
comparison between iprf with vit. c and iprf alone in management of id'pain

Conditions: TMJ Pain

Summary: randomized clinical trial between 2groups,the study group to be injected in the tmj with injectable platelet rich fibrin with vitamin c and the control group to be injected in the tmj with injectable platelet rich fibrin alone in management of internal temporomandibular joint derangement

randomized clinical trial between 2groups,the study group to be injected in the tmj with injectable platelet rich fibrin with vitamin c and the control group to be injected in the tmj with injectable platelet rich fibrin alone in management of internal temporomandibular joint derangement

Eligibility criteria:
inclusion criteria: patients with internal tmj derangement (anterior disc displacement with reduction) exclusion criteria: pathological conditions ; trauma tmj cases or any blood diseases
treatment of globus sensations with psychotherapy

Conditions: Somatoform Disorders; Globus Hystericus

Summary: the purpose of this study is to determine whether psychotherapy (based on exposure techniques) is effective in the treatment of functional somatic symptoms (fss)/somatoform disorders (as exemplified here in subjects with globus sensations in the throat).

functional somatic symptoms (fss) and somatoform disorders are characterized by the presence of medically unexplained symptoms. they are among the most prevalent disorders in the general medical setting, leading to individual suffering and having huge impact on public health alike. unfortunately, many patients still remain untreated and not all patients get better, even when receiving currently proposed treatments. the aim of the present project is twofold: first, we want to improve the understanding of risk factors and psychobiological processes leading to the development of fss. second, we will explore and evaluate new ways of treating subjects with fss. within the project, we will examine subjects with globus sensations in the throat, a very common und impairing form of fss. the proposed study i) may provide insight into the development of fss, thereby improving our way by which we recognize and diagnose subjects with fss, and ii) may help fostering our understanding of how to better treat subjects suffering from fss.

Eligibility criteria:
inclusion criteria: * sufficient spoken and written knowledge of german * presence of globus sensations and somatoform disorder * clinically significant impairment exclusion criteria: * current (past 12 months) severe chronic physical illnesses, especially neurological, endocrine or metabolic diseases * current (past 12 months) substance dependence or eating disorder * lifetime history of psychotic disorder or bipolar disorder

Keywords: somatoform disorder functional somatic syndrome functional somatic symptoms somatic symptom disorder globus sensation globus pharynges globus hystericus
the effect of different virtual reality-based exercise trainings on pulmonary function, respiratory and peripheral muscle strength, functional capacity and balance in children with bronchiectasis

Conditions: Bronchiectasis

Summary: bronchiectasis is defined as abnormal, chronic and permanent enlargement of one or more bronchi. disease symptoms; often productive cough, dyspnea, fatigue and wheezing. changing pulmonary mechanics, inadequate gas exchange, decreased muscle mass and associated psychological problems may cause dyspnea, decreased exercise capacity and health-related quality of life. exercise training as a part of pulmonary rehabilitation is used to reduce the severity of symptoms; is an effective treatment to improve exercise capacity and health status. virtual reality based exercise training has taken its place in many areas of rehabilitation as a current and new approach. in the studies in the literature, nintendo wii fit games are an effective, motivating, entertaining and clinically useful method for reducing symptoms in the rehabilitation of chronic lung diseases. wii fit games generally include strengthening, aerobics and balance exercises. developed by breathinglabs, breathing games, which is based on breathing exercises, are a new product, a virtual reality application that has been included in a limited number of studies, has shown its effect on reducing respiratory problems and is open to research effects for many patient groups. the importance of this study is that it will be the first study on nintendo wii fit games based exercise training and breathing games based breathing exercises training in children with bronchiectasis. the aim of this study is to investigate the effect of different virtual reality-based exercise trainings on pulmonary function, respiratory and peripheral muscle strength, functional capacity and balance in children with bronchiectasis.


Eligibility criteria:
inclusion criteria: * bronchiectasis diagnosis * stable clinical condition (no exacerbation in last 4 weeks) exclusion criteria: * documented diagnosis of vestibular, neurological or orthopedic disorders which may affect balance and mobility * subjects previously involved in exercise training or physiotherapy programs * previous history of lung or liver transplantation

Keywords: bronchiectasis virtual reality exercise training pulmonary function functional capacity 6 minute walk test balance muscle strength
minocycline attenuate postoperative cognitive dysfunction and delirium

Conditions: Prostate Cancer; Carcinoma of the Rectum; Colon Cancer; Renal Carcinoma

Summary: postoperative cognitive dysfunction (pocd) and postoperative delirium occurs mainly in aged patients. pocd and pod may increase the mortality and morbidity. however, the mechanism of pocd is not clear yet and no effective therapy method was proved. according to previous study, the neuroinflammation is the main reason both for pocd and pod. minocycline is a tetracycline derivative. due to it's lipophilic structure, it is easy to pass through blood brain barrier and attenuate neuroinflammation. it's neuroprotective effects has been proven in many experimental animal models such as alzheimer's disease, huntington's disease and parkinson's syndrome. in present study, the investigators hypothesized that minocycline would attenuate the incidence of pocd and pod in the aged patients.


Eligibility criteria:
for the placebo and minocycline group; inclusion criteria: 1. elder than 65 years old 2. speak chinese mandarin 3. those who will undergo major general surgery like colorectal cancer excision, major urinary surgery like radical prostatectomy and radical nephrectomy 4. signed the inform consent 5. american society of anesthesiologists classification i to iii exclusion criteria: 1. existing cerebral disease, or have a history of neurological and psychiatric diseases including alzheimer disease, stroke, epilepsy and psychosis; 2. existing cognitive impairment as evidenced by mini-mental state examination scores below 24; 3. severe audition or vision disorder; 4. unwillingness to comply with the protocol or procedures. 5. cannot communicated with chinese mandarin 6. with severe skin disease 7. serious heart or liver or renal insufficiency patients 8. had surgery in the past 30 days 9. allergy to tetracycline or minocycline for the health volunteers; inclusion criteria: 1. elder than 65 years old 2. speak chinese mandarin 3. signed the inform consent 4. no major disease health people exclusion criteria: 1. existing cerebral disease, or have a history of neurological and psychiatric diseases including alzheimer disease, stroke, epilepsy and psychosis; 2. existing cognitive impairment as evidenced by mini-mental state examination scores below 24; 3. severe audition or vision disorder; 4. unwillingness to comply with the protocol or procedures. 5. cannot communicated with chinese mandarin 6. drug abuse, alcoholism 7. serious heart or liver or renal insufficiency patients 8. had surgery in the past 30 days 9. plan to undergo surgery in the following 3 months.

Keywords: minocycline postoperative cognitive dysfunction postoperative delirium
probiotics improve health young volunteers' gut microbiota

Conditions: Gastrointestinal Diseases

Summary: the goal of this clinical trial is to evaluate whether daily supplementation with the probiotic bifidobacterium breve bbr60 can improve metabolic, gastrointestinal, and emotional health in healthy adult volunteers aged 19 to 45 years. the main questions it aims to answer are: can b. breve bbr60 improve lipid metabolism (e.g., increase hdl and reduce total cholesterol) in healthy adults? can b. breve bbr60 alleviate gastrointestinal symptoms and improve emotional well-being in a non-clinical population? researchers will compare a bbr60 supplementation group to a placebo group to see if the probiotic group experiences greater improvements in metabolic, gastrointestinal, and psychological indicators. participants will: take one sachet daily of either b. breve bbr60 (10 billion cfu) or placebo for 8 weeks. provide blood and stool samples at baseline and week 8. complete validated questionnaires assessing alcohol dependence, gastrointestinal symptoms, and emotional status.


Eligibility criteria:
inclusion criteria: 1. aged 19-45 years; 2. willing to voluntarily agree to and comply with the trial protocol, and capable of timely participation in screening and follow-up; 3. have not suffered from gastrointestinal diseases in the past month; 4. have not taken antibiotics in the past month. exclusion criteria: 1. individuals under 19 or over 45 years of age, with an allergic constitution or allergy to any component of the test substance, symptoms of alcohol allergy, and pregnant or breastfeeding women; 2. those who experience discomfort such as diarrhea or bloating after taking the test substance; 3. patients with serious diseases of the cardiovascular, liver, kidney, hematopoietic systems, autoimmune diseases, endocrine disorders, mental illnesses, existing high blood sugar, or unhealthy gastrointestinal conditions; 4. those who discontinue the test sample or take other medications midway, making it difficult to judge efficacy or with incomplete data; 5. recently taken probiotics, prebiotics, or antibiotics related to the function of the test substance, affecting the judgment of results; 6. individuals with a daily diet that is either too light or too greasy; those with special dietary structures due to weight loss or other reasons (such as a ketogenic diet); 7. individuals with low body fat, bmi \< 23.
the effect of n-3 lcpufa on immune function and cardiovascular risk factors

Conditions: Cardiovascular Heart Disease; Metabolic Syndrome

Summary: the purpose of this study is to investigate the effects of long-chain n-3 polyunsaturated fatty acids (n-3 lcpufa) on immune function and cardiovascular disease risk

in a controlled, double-blinded human intervention study the effects of fish oil versus control (olive oil) and of a high versus low consumption of n-6 polyunsaturated fatty acids are investigated. sixty-seventy healthy men will be randomized to oil capsules and to substitute their dietary fats with one of two types of oil and butter-product that we provide. outcome variables are ex vivo cytokine production in full blood and isolated immune cells after 24 h of stimulation with bacteria or bacterial components, blood pressure and arterial function, plasma concentrations of cholesterol, triacylglycerol, c-reactive protein and a number of other markers of endothelial function and cardiovascular risk. the hypotheses are that both increased intake of n-3 polyunsaturated fatty acids (from fish oil) and a low consumption of n-6 polyunsaturated fatty acids increase incorporation of docosahexanoic acid in immune cell membranes and that this decreases the inflammatory response and potential and improve overall cardiovascular disease risk. the mechanistic aspects of this will be further explored by in vitro studies with monocytes cultured in the presence of varying amounts of polyunsaturated fatty acids.

Eligibility criteria:
inclusion criteria: * healthy (no chronic diseases and no regular medications) * bmi \>18.5 and \<27.5 kg/m2 * daily use of fats and home cooking \>5 d/wk * heavy exercise \<7 h/wk * not daily smokers (\<5 cigarets/wk) exclusion criteria:

Keywords: fish oil polyunsaturated fatty acid immune function endothelial function cardiovascular risk factors
prediction of hypotension using perfusion index and pleth variability index after spinal anesthesia for c/s

Conditions: Cesarean Section Complications; Hypotension; Spinal Anesthesia; Perfusion Index; Pleth Variability Index

Summary: spinal anesthesia for caesarean section is associated with a decrease in systemic vascular resistance and cardiac output and may cause hypotension in a significant portion of the parturients. hypotension during delivery may cause maternal and fetal complications. if parturients who are likely to develop hypotension after spinal anesthesia can be identified before surgery, anesthesiologists would have opportunity to take measures such as prophylactic vasopressor administration. perfusion index (pi) measured by pulse oximetry reflects vasomotor tone which affects the degree of hypotension after spinal anesthesia. this is a non-invasive method of assessing the relative vascular tone with the use of pulse oximeter which calculates the ratio of pulsatile versus the non-pulsatile component of the blood flow. a lower pi indicates greater peripheral vasomotor tone. pleth variability index (pvi) is calculated using maximum and minimum values of perfusion index during respiratory cycles. pvi is one of the dynamic indices that can predict fluid responsiveness. the aim of this study is to investigate whether the pi and pvi values at different patient positions can predict hypotension during caesarean section.


Eligibility criteria:
inclusion criteria: * singleton parturient * planned for elective lscs under spinal anesthesia exclusion criteria: * gestational age \< 36 weeks * emergency cases * placenta previa, pre-eclampsia * bmi\>40 * reynauld disease * patient refusal * cardiovascular disease
positron emission tomography (pet) imaging of glial activation in psychotic disease states

Conditions: Schizophrenia; Bipolar Disorder

Summary: many neurological diseases, including aids dementia, alzheimer's disease and schizophrenia, involve an inflammatory component thought to specifically involve glial cell activation. the investigators has been concerned with the development of tools for noninvasive imaging of inflammatory processes in psychotic disease. here, the investigators aim to use pet-based neuroimaging with carbon-11 n,n-diethyl-2-(4-methoxyphenyl)-5,7-dimethylpyrazolo\[1,5-a\]pyrimidine-3-acetamide, (\[11c\]dpa)-713 to quantify regional distribution of translocator protein (tspo), a putative marker of inflammation, in the brains of patients with schizophrenia and bipolar disorder, type i. the investigators will focus on patients in the early stages of disease (within first five years of onset of schizophrenia diagnosis and within first five years of first manis, respectively) to minimize the confounds of age-, chronic illness-, and medication- effects on our results.


Eligibility criteria:
inclusion criteria: * healthy volunteers 18-65 years of age * patients diagnosed with recent onset schizophrenia (within 5 years of onset), 18-65 years of age * patients diagnosed with recent onset bipolar disorder (within 5 years of onset of first mania), 18-65 years of age * screening laboratory tests will be obtained for subjects within a 10 day period prior to the pet study and the results must be within normal limits for gender and age. these tests will be repeated with a 7-day window following the pet study * ekg conducted within 10 day period prior to the pet study. the ekg will be repeated within 7 days following the study. * subject agrees to return to the hospital for a follow-up ekg and laboratory testing of blood and urine. * for females of childbearing potential, negative serum pregnancy test within a 10 day period prior to pet study. exclusion criteria: * history of recent nosocomial infection, * history of chronic neurological disorder, such as multiple sclerosis or epilepsy, or structural,central nervous system (cns) abnormality such as stroke or arteriovenous malformation, * history of head injury with loss of consciousness \> 1 hour, * history of active substance abuse as defined by substance abuse including alcohol abuse over the 6 months prior to the study, * dependence on benzodiazepine medication * contraindications to mri scanning to include pacemakers, metallic implants/prosthesis or prohibitive claustrophobia, etc. * contraindications to pet scanning to include pregnancy, etc. for females of childbearing potential, negative serum pregnancy test less than 10 days prior to pet study * ecg demonstrating the patient is not in a sinus rhythm or is having acute ischemia. * any medical condition that in the opinion of the study investigators would constitute a safety risk to the subject.
natural history and clinical features of amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis

Summary: 1. describe the distribution of als in mainland china, to explore the differences in the number of als in different times, regions and populations in order to further explore the causes affecting the distribution of als; 2. to investigate the cause of als in mainland china in the crowd disease development process and the corresponding characteristics change ; 3. to explore the effect of prognosis of als;

with the development of supportive measures, the natural history of als has changed. researchers compared the natural history of als patients from 1999-2004 and 1984-1998 and found that the median survival time was significantly longer in the former than in the latter (4.32 years vs. 3.22 years) and that the disease progression was slower in the former, even after adjusting for other confounding factors. although previous studies have provided reference for the diagnosis and treatment of als, the etiology of als is still unknown, and the relevant clinical features and natural history of als still lack the verification of large samples. therefore, the research on the natural history of als is of great significance to further increase the understanding of als and provide new evidence for the diagnosis and treatment of als.

Eligibility criteria:
inclusion criteria: - patients were diagnosed with als recruited from all participant clinical centers.the diagnosis of als was made using the revised el escorial criteria for definite, probable, lab-supported, and possible. exclusion criteria: * decline to follow-up.

Keywords: amyotrophic lateral sclerosis; epidemiology
neurobiology of opioid dependence: 1 - 1

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to evaluate the effects of lamotrigine on naloxone-precipitated opiate withdrawal.


Eligibility criteria:
please contact site for information.

Keywords: opioid disorders
volumetric intensity modulated arc therapy vs. conventional radiotherapy for cancer pain

Conditions: Neoplasm Metastasis; Pain; Radiotherapy Side Effect; Quality of Life

Summary: this study compares the use of conventional radiotherapy technique with volumetric intensity-modulated radiotherapy (vmat) in the treatment of painful cancer metastases. half of the patients will receive radiotherapy using a conventional technique, while the other half will receive their treatment using a the vmat technique.

radiotherapy to painful sites of metastasis can provide pain relief. side-effects from radiotherapy is dependent on the volume and dose received by normal tissues. conventional radiotherapy techniques delivers similar doses of radiation to the targeted cancer lesion and the normal tissues along the entrance and exit paths of the radiation. volumetric intensity-modulated arc therapy (vmat) is an advanced technique of radiotherapy that spares normal tissues from receiving high-dose irradiation. however, vmat increases the volume of normal tissues receiving low-dose irradiation. this study aims at comparing the quality of life and side-effect profiles of patients treated by palliative radiotherapy using the conventional technique vs. vmat.

Eligibility criteria:
inclusion criteria: 1. pain (sf-bpi score ≥1) should be related to metastases (bone or others) or to the tumor itself 2. capable of providing the full list of analgesic medication being used 3. capable of completing the sf-bpi and eortc questionnaires without any help 4. life expectancy of at least 3 month 5. kps greater or equal to 50 6. radiotherapy to 1 site pain 7. site of treatment not previously irradiated 8. no planned changes in analgesic within 7 days before and after treatment • patient may be started on dexamethasone on the first day of radiotherapy 9. no planned chemotherapy, radiotherapy or surgery within 7 days before and after treatment 10. patient provided informed consent to participate in this study exclusion criteria: 1. major mental or psychiatric impairments, which in the investigator's opinion will prevent administration or completion of the protocol therapy and/or interfere with follow-up. 2. treatment to upper and lower limb 3. treatment to 2 or more sites of pain 4. re-irradiation of the site of treatment 5. women who are pregnant 6. life expectancy less than 3 month

Keywords: intensity-modulated radiation therapy volumetric intensity-modulated arc therapy radiotherapy pain metastasis quality of life acute toxicity
effect of postoperative laxative on bowel function after colonic surgery

Conditions: Colonic Cancer

Summary: randomised doublet blinded study of the effect of tablet magnesia (laxative) on post operative bowel ileus after open colonic resection. material: 56 patients in two equal groups. primary endpoint: bowel function. secondary endpoints: intake of food and drinks.


Eligibility criteria:
inclusion criteria: * patients with planned elective colonic resection exclusion criteria: * previous extended abdominal surgery * pregnancy * opioid or alcohol abuse