Kornimate/medical-research-clean huggingface dataset:
the effect of tranexamic acid on uterine blood flow after vaginal delivery

Conditions: Postpartum Hemorrhage

Summary: postpartum hemorrhage is the most common cause of maternal death across the world, responsible for more than 25% of maternal deaths annually. although effective tools for prevention and treatment of are available, most are not feasible or practical for use in the developing world where many births still occur at home with untrained birth attendants . primary postpartum hemorrhage is excessive bleeding from or in the genital tract within 24 hours of delivery of the fetus which affects the general condition. postpartum hemorrhage is responsible for around 25% of maternal mortality worldwide , reaching as high as 60% in some countries. postpartum hemorrhage can also be a cause of long-term severe morbidity, and approximately 12% of women who survive postpartum hemorrhagewill have severe anemia. tranexamic acid is an antifibrinolytic compound which is a potent competitive inhibitor of the activation of plasminogen to plasmin. at much higher concentrations it is a non-competitive inhibitor of plasmin. the inhibitory effect of tranexamic acid in plasminogen activation by urokinase has been reported to be 6-100 times and by streptokinase 6-40 times greater than that of aminocaproic acid.


Eligibility criteria:
inclusion criteria: * pregnant women (37-42 weeks), * with spontaneous labor * women who were expected to normal vaginal birth. * women with a live fetus. exclusion criteria: * multiple gestations * polyhydramnios * macrocosmic baby * grand multipara * women with hypertensive disorders * previous history of postpartum hemorrhage * abnormal placentation (placenta previa or placental abruption) * history of any uterine scarring (including cesarean section) * history of blood/liver/renal/heart diseases.
the effect of a self-management lymphedema education program on lymphedema, symptoms, compliance, daily living activities, and patient activation in breast cancer-related lymphedema: a quasi-experimental study

Conditions: Breast Cancer Survivor; Lymphedema

Summary: the aim of this pre-test post-test quasi-experimental study is to evaluate the effects of a self-management lymphedema (sml) education program on patient adherence, daily life activities, and patient activation in individuals with breast cancer-related lymphedema (bcrl). this study involves 44 patients diagnosed with bcrl and is conducted at hacettepe university oncology hospital lymphedema diagnosis and treatment application and research center. upper extremity lymphedema assessments are performed at the beginning of the study, followed by the implementation of a structured sml education program. participants are monitored for a total of 12 months. data collection tools include the personal information form, upper extremity lymphedema diagnosis form, adaptation to chronic illness scale, katz daily living activities index, disability of arm, shoulder, and hand questionnaire, and patient activation measure.

this study focuses on evaluating the potential benefits of a structured self-management lymphedema education program in patients with breast cancer-related lymphedema. it aims to improve patient adherence, activation, and daily life activity levels through a comprehensive education-based intervention.the study was conducted as a master's thesis and has been completed.

Eligibility criteria:
inclusion criteria: * being female, * aged 18 years or older, * having undergone axillary lymph node dissection, * having undergone breast cancer surgery, * diagnosed with lymphedema (stage 1-2), * individuals with no surgical plans during the study period. exclusion criteria: * not diagnosed with lymphedema, * having a medical condition that prevents exercise, * having advanced-stage heart or kidney failure, * patients who refused to participate in the study.

Keywords: breast cancer-related lymphedema daily life activities patient activation patient adaptation patient education self-management of lymphedema
stanford coronary risk intervention project (scrip)

Conditions: Cardiovascular Diseases; Coronary Arteriosclerosis; Coronary Disease; Heart Diseases; Myocardial Ischemia

Summary: to determine whether modification of risk factors altered the rate of progression of coronary artery disease in arteries with mild atherosclerosis and no mechanical intervention in patients who had coronary bypass surgery or percutaneous transluminal coronary angioplasty (ptca).

background: because of difficulties with quantitative measurement and with feasibility of follow-up, few controlled studies prior to scrip had been completed to determine the impact of risk factor modification directly on the progression of coronary atherosclerosis in humans. suggestive evidence existed from animal studies, especially in primates, that diet and exercise altered atherosclerosis as a result of risk modification. but these animal models did not accurately represent the potential for modifying the coronary atherosclerotic process in humans. some indirect evidence had been developed in humans by studying arteries more accessible than the coronaries. in the several preliminary studies reported using coronary arteriography to study the impact of risk modification on atherosclerosis, the results had been encouraging but far from definitive. one angiographic follow-up study of vein bypass grafts and severely atherosclerotic coronary arteries reported improvement with lipid lowering therapy. none of these studies had included randomization of patients to systematic, intense, long-term risk reduction versus usual care with prospectively identified coronary artery segments with mild disease. design narrative: randomized, fixed-sample. a total of 300 patients were randomized, 155 to usual care (uc) in the community and 145 to special intervention (si). the si group received intensive efforts directed at reducing or eliminating risk factors, including lowering ldl-cholesterol and increasing hdl-cholesterol, reducing blood pressure, eliminating cigarette smoking and obesity, increasing exercise, and decreasing stressful life experience. the major endpoint was the rate of coronary artery disease progression as measured by angiography, at baseline and at forty-eight months. follow-up was for four years.

Eligibility criteria:
men and women, up to 75 years of age. patients with coronary artery disease but no mechanical intervention on all major vessels.
the effect of laughter yoga on hope and school burnout

Conditions: Laughter Therapy; Laughter Yoga; Hope; School Burnout

Summary: this study aimed to evaluate the effect of laughter yoga on hope and school burnout among secondary school (8th grade) students. the study hypothesized that laughter yoga would have an effect on hope and school burnout scores among secondary school students

purpose: the aim of the research was to examine the effects of laughter yoga on life hope and school burnout among secondary school (8th grade) students. methods: the study was conducted with 60 (30 in the intervention group, and 30 in the control group) students. the study population consisted of 8th grade students. laughter yoga sessions were applied to the intervention group twice a week for 6 weeks. no intervention was offered to the control group. data were collected by a socio-demographic questionnaire, school burnout inventory and children's hope scale. results: after laughter yoga, the intervention result showed a significant decrease in burnout (d=0.129; p \< 0.001) and increase hope scores (d=0.556; p \< 0.001) compared to the control group. conclusion: the study reveals that laughter yoga affects students' burnout and hope levels. it is recommended to organize laughter yoga activities in schools to decrease burnout and increase hope of students.

Eligibility criteria:
inclusion criteria: * the inclusion criteria of the study were determined as being an 8th-grade student, speaking and understanding turkish, and being able to perform daily life activities. exclusion criteria: * having severe hearing or perceptual deficits that impaired communication; having dementia, alzheimer's disease, depression, uncontrolled diabetes, hypertensive disease and surgical operations with the risk of bleeding.
posture and pain measurements in post-covid-19

Conditions: COVID-19 Respiratory Infection

Summary: in this study, it was aimed to reveal the results of posture measurement evaluated by artificial intelligence method, pain status and musculoskeletal disorders in individuals who have had covid-19.

thanks to artificial intelligence and machine learning technology, evaluations such as balance and foot pressure measurement can be made in patients today, as well as applications such as exercise and patient follow-up in rehabilitation, solutions to biomedical problems can be offered. artificial intelligence and machine learning will continue to play an important role in education, training, patient care and research in the future. on the other hand, although various psychological and physical problems have been shown in individuals who have had covid-19 during the prolonged covid-19 pandemic process, musculoskeletal disorders and posture problems in these individuals remain unclear. for this reason, in this study, it was aimed to reveal the results of posture measurement evaluated by artificial intelligence method, pain status and musculoskeletal disorders in individuals who have had covid-19.

Eligibility criteria:
inclusion criteria: * adult individuals aged 18 and over * volunteering to participate in the study, * individuals who can understand and answer the questionnaires * individuals who were diagnosed with covid-19 (individuals with a positive polymerase chain reaction (pcr) test result, compatible with covid-19 infection as a result of lung x-ray or lung tomography despite negative pcr test results) and discharged after recovery/home quarantine completed exclusion criteria: * individuals with any physical or mental disability/disease and/or cognitive impairment * individuals newly diagnosed with covid-19, therefore in quarantine at home or receiving treatment in hospital * individuals with suspected covid-19 * pregnant women

Keywords: pain posture
safety of treatment of uterine fibroids with asoprisnil

Conditions: Fibroid Uterus; Leiomyoma; Menorrhagia; Metrorrhagia; Uterine Fibroids

Summary: the objective of this study is to determine the long-term safety of asoprisnil in women with symptomatic uterine fibroids who completed the 6 month study c02-037.

no medical therapy is currently available for the long-term treatment of abnormal uterine bleeding associated with uterine fibroids in women and many women must resort to surgery for relief. the objective of this study is to determine the long-term safety of asoprisnil 10 and 25 mg administered daily for 18 months to subjects with symptomatic uterine leiomyomata who completed the 6 month study c02-037. the safety endpoints for this study will be based on assessments of the endometrium, ovarian cysts, lipid profiles, adverse events and clinical laboratory evaluations. some subjects receiving asoprisnil developed endometrial changes. as a result, dosing was prematurely discontinued for all subjects. to ensure safety, subjects will remain on study and will undergo scheduled study procedures. in most subjects, endometrial changes reversed after asoprisnil discontinuation.

Eligibility criteria:
inclusion criteria: * women that have completed 6 months of treatment in study c02-037 with no more than a 7-day interruption in their treatment * otherwise good health * premenopausal based on estrogen and follicle stimulating hormone levels * agrees to double-barrier method of contraception * adequate endometrial biopsy with no significant histological disorder exclusion criteria: * any abnormal lab or procedure result(s) the study-doctor considers important * history of a blood-clotting disorder * any prior surgical and/or invasive procedure(s) for uterine fibroids that resulted in either a cure or made the symptoms go away * significant gynecological disorder, such as endometrial polyp

Keywords: symptomatic uterine fibroids excessive uterine bleeding uterine hemorrhage asoprisnil
pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia

Summary: in a population-based study to explore the impact of tpmt-status on the risk of relapse and of second cancer among all patients treated according to the nopho all2000.

the thiopurines 6-mercaptopurine (6mp) and 6-thioguanine (6tg) are widely used in the treatment of childhood acute lymphoblastic leukemia (all). they primarily exert their cytotoxicity through conversion into 6-thioguanine nucleotides (6tgn) that are incorporated into dna. interindividual variations in response to thiopurine therapy are influenced by genetically determined polymorphisms in the activity of the enzyme thiopurine methyltransferase (tpmt). tpmt competes with the formation of 6tgn, as it methylates the thiopurines (especially 6mp) and some of their metabolites. approximately ten percent of all individuals are tpmt heterozygous, with one wild type and one low activity allele, and one in three hundred individuals are tpmt deficient with two low activity alleles. during the maintenance therapy phase of the treatment of childhood all, which may last several years, 6mp is given on a daily basis at a starting dose of 75 mg/m.sq./day, which is subsequently adjusted to a white blood cell count of 1.5-3.5 x109/l. we have previously demonstrated that the risk of relapse is reduced by more than 50%, but the risk of second cancer was increased 3-fold among tpmt low activity patients. accordingly, the nordic all2000 protocol recommended the dosing of 6mp to be based on the patients tpmt activity. in the present study of almost 1000 nordic patients, we will explore whether this strategy of tpmt-based individualised 6mp dosing have benefitted the patients by reducing their risk of second cancer while preserving their low risk of relapse.

Eligibility criteria:
inclusion criteria: * included in the nopho all2000 protocol * entered 6-mercaptopurine/methotrexate maintenance therapy in first remission * available tpmt phenotype and/or genotype exclusion criteria: * children with down syndrome
a study to assess current standard malaria treatment guidelines in the republic of the sudan

Conditions: Malaria

Summary: this is a randomized controlled trial to assess the efficacy and safety of the national malaria treatment guidelines, asses the efficacy and safety of artesunate and sulphadoxine - pyrimethamine (as+sp) for treatment in uncomplicated p. falciparum and p. vivax malaria and the hematologic effect of 14 days routine primaquine based radical cure in patients suffering from a p. vivax or mixed infection.


Eligibility criteria:
inclusion criteria: * age ≥ 12 months * p. vivax or p. falciparum mono-infection or p. vivax / p. falciparum mixed infection * presence of axillary temperature ≥ 37.5°c or history of fever during the past 24 hrs * able to tolerate oral medication * able and willing to comply with the study protocol for the duration of the study * informed consent from the patient or from a parent or guardian in the case of children exclusion criteria: * bodyweight ≤5kg * presence of general danger signs in children aged under 5 years or signs of severe malaria in any patient according to the definitions of who * presence of severe malnutrition * acute anaemia \<8g/dl * regular medication, which may interfere with antimalarial pharmacokinetics * history of hypersensitivity reactions or contraindications to any of the drug(s) tested or used as alternative treatment(s) * a positive pregnancy test or lactating.
intervention study to investigate supplemental oxygen in copd

Conditions: COPD; Physical Activity; Sedentary

Summary: the purpose of this trial is to study the effects on exercise capacity, physical activity, inflammatory markers and quality of life of supplemental ambulatory oxygen, to be used during physical activity, in patients with copd who are normoxic at rest but hypoxemic during a six-min walk test. our hypothesis is that if patients are able to use supplemental oxygen they will be more physically active and thereby improve health related quality of life.

study design the study will employ a parallel design for 6 months including 144 patients (72 patients/group). patients will be randomized to intervention or control group. the intervention comprises supplemental oxygen to be used during physical activity for 6 months. the control group will receive the same physical activity instructions as the intervention group during the 6 months, but they will not be able to use supplemental oxygen during physical activity. the study will be a prospective, randomized, single-blind multi-centre intervention study with an intention to treat design (last value carry over). inclusion will continue until 144 patients have fulfilled the 6 months. patients will be tested at baseline and after 6 months. there will also be a follow-up after 12 months comprising questionnaires. the study will include centers in sweden norway, finland, and estonia.

Eligibility criteria:
inclusion criteria: * copd, arterial oxygen saturation \> 8 kilopascal at rest * oxygen saturation ≤ 88% and a fall in oxygen saturation ≥ 4% during a six-minute walk test in ambient air * no exacerbation within 4 weeks prior to the study * post-bronchodilator forced expiratory volume at one second \< 80% predicted and forced expiratory volume at one second /vital capacity \< 0.7 * oxygen saturation ≥ 92 % during a walk test in self-selected pace with supplemental oxygen. patients should use supplemental oxygen 10 minutes before the test starts. * non-smoker (smoke free for ≥ 6 months) * interest in being physically active exclusion criteria: * arterial carbon dioxide \> 6.5 kilopascal at rest * orthopedic, neurologic or mental impairments that would limit physical activity * neoplastic disease that is anticipated to influence survival * patients exercising with supplemental oxygen * long-term oxygen therapy * patients with arterial auricular fibrillation and/or heart disease that might hinder physical activity as judged by the physician

Keywords: copd physical capacity physical activity inflammatory markers health related quality of life
comparison of lidocaine spray and paracervical block application for pain relief during first-trimester surgical abortion: a randomized, double-blind, placebo-controlled trial

Conditions: Pain Score

Summary: objective: the investigators sought to investigate the analgesic efficiency of lidocaine spray, paracervical block (pcb) with lidocaine and pcb with lidocaine plus lidocaine spray combination in patients undergoing first-trimester surgical abortion. methods: a randomized, double-blind, placebo-controlled clinical trial was conducted on 108 women with the request of pregnancy termination.the subjects were randomly assigned into four groups: pcb (n=27), lidocaine spray (n=27), pcb plus lidocaine spray (n=27) and placebo(n=27).intraoperative and postoperative pain scores were measured with a standard visual analog scale (vas).


Eligibility criteria:
inclusion criteria: age \>18 years single pregnancy \<7 weeks of gestation exclusion criteria: incomplete abortion early pregnancy failure acute cervicitis untreated pelvic inflammatory disease cervical stenosis

Keywords: abortion analgesia paracervical block lidocaine spray
radioguided occult lesion localisation by indocyanine green

Conditions: Breast Cancer Female

Summary: breast cancer is the most common cancer in women. it is the main cause of cancer deaths among women. the incidence of non-palpable tumors is estimated at 60%. their better prognosis and their small size encourage the investigators for finding methods simpler and more efficient to treat them by breast-conserving surgery with acceptable cosmetic results. the pre-operative detection of the tumor lesion is currently carried out by two methods: the radioactive seed localization and guidewire technique. each has its disadvantages: the guidewire is uncomfortable for the patients (pain, hematomes..), whereas the radiocolloid requires a specialized and complex organization around this radioactive product. recently, a novel method of using indocyanine green (icg) fluorescence has been described in breast cancer and seems promising. in this study, investigators evaluate the feasibility and performance of indocyanine green fluorescence in non-palpable tumor detection in comparison with radioactive seed localization (roll) secondary objectives are evaluate the feasibility of the location by the radiologist, feasibility of detection by the surgeon, study of the product and the probe.

the study is prospectively conducted during six months of 2017-2018 in the department of gynaecology of montpellier . this study includes ten women. patients will receive both techniques: indocyanine green fluorescence (experimental technique) and radiocolloid (reference technique). inclusion will be during the preoperative consultation after checking the inclusion / non inclusion criteria and signing a written consent. radioactive localization with technetium will be done on surgery eve like usual. fluorescence localization with icg will be done in the operating room under general anesthesia by the radiologist under ultrasound. by a probe (euromedical instruments), surgeon identified and marked the site of the skin by observing the area of the icg fluorescence. then, in the same way, the surgeon marked the tumor by the radioactive probe detecting the radioactive signal. an picture will be made of these two markers and it will be noted the distance between them. dissection and excision of the tumor using the radiocolloid probe (no modification of surgical management). at the end of the surgical procedure, verification of no residual radioactivity and no residual fluorescence. again, surgeon identified and marked in the excised sample the area of fluorescence and radioactive. the pathological examination of the resected specimen will describe positions of mark compared tumor. the following data were recorded prospectively: demographics, medical history, localization of tumor, surgery, pathology results.

Eligibility criteria:
inclusion criteria: * woman age ≥ 18 years * non-palpable tumor * single tumor * first breast surgery * histology: ductal carcinoma * written consent * being affiliated or benefiting from a french social security system exclusion criteria: * palpable tumor * multifocal tumor * antecedent of breast surgery