Kornimate/medical-research-clean huggingface dataset:
effects of two packing type in maxillofacial surgery

Conditions: Sore Throat; Nausea and Vomiting, Postoperative

Summary: operations of oral maxillofacial surgery cause the blood escape into stomach and trachea. therefore, throat packing is applied. endotracheal tube cuff is not protective from aspiration. while packing is preventing blood leakage, it may cause postoperative pain due to the pressure. packing placed between oropharynx and hypopharynx before surgery to prevent leakage to stomach and trachea. the aim of this study is to compare the efficacy of two packing types in throat pain.


Eligibility criteria:
inclusion criteria: 1. patients who underwent oral maxillofacial surgery (maxillary and mandibular cysts, orthognathic surgery, palate and alveolar clefts, mandibular and maxillary fractures and reconstruction surgeries) under general anesthesia between the ages of 18-60 2. asa 1-2 groups of patients 3. patients who have completed growth and development 4. patients who are willing to comply with the requirements of the study 5. patients with complete medical records 6. operations expected to last at least 2 hours exclusion criteria: 1. patients with severe systemic disease other than asa 1-2 2. difficult entubation story 3. patients with bmi\> 35 kg / m2 4. contraindications for the use of nsaids 5. patients with diclofenac sodium and metoclopramide allergy 6. patients whose medical records are inadequate 7. patients with major tranquilizer or opiate addiction 8. patients with mental and physical anxiety that would interfere with cooperative operation
intravenous erythromycin before endoscopy in patients with variceal bleeding: a randomized, double-blind trial

Conditions: Variceal Bleeding

Summary: objectives: blood in stomach \& oesophagus in patients with variceal bleeding often obscures the endoscopic view \& makes endoscopic intervention difficult to perform. erythromycin, a motilin agonist induces gastric emptying. the aim of this study was to assess the effect of erythromycin on endoscopic visibility and its outcome.

methods: adult patients with liver cirrhosis or stigmata of chronic liver disease presenting with hematemesis and or melena within previous 12 hours were randomized in a double blind trial to receive either 125 mg erythromycin or placebo 30 minutes before endoscopy. the primary end points were endoscopic visibility assessed by objective scoring system \& mean endoscopy duration. secondary end points were need for repeat endoscopy and blood transfusions within 24 hours of first endoscopy , endoscopy related complications and length of hospital stay.

Eligibility criteria:
inclusion criteria: * adult patients with liver cirrhosis or stigmata of chronic liver disease presenting with hematemesis and or melena within previous 12 hours with * age \>18 years * informed consent * hemodynamically stable patient at the time of endoscopy after resuscitation. exclusion criteria: * known allergy to erythromycin * prior gastric lavage on admission * current use of antiarrhythmic drugs * prior gastric surgery * previous history of cardiac arrhythmias * concomitant use of antihistaminic drugs with possible drug interactions with erythromycin * prior use of other prokinetic agents * pregnancy or lactation
vico-trial: video consultations in the follow-up of children with functional abdominal pain disorders

Conditions: Functional Abdominal Pain Disorders; Irritable Bowel Syndrome (IBS); Functional Dyspepsia; Abdominal Migraine

Summary: the goal of this non-inferiority randomized controlled multi-center trial is to investigate the use of video consultations in the follow-up care of children aged 4 - 18 years old with functional abdominal pain disorders (fapds). video consultations will be compared to face-to-face consultations. clinical outcomes and patients' and parents' healthcare experience will be compared between both groups. primary outcome is adequate relief after 12 weeks: the hypothesis is that video consultations are not inferior to face-to-face consultations regarding clinical outcomes and that adequate relief will be the same for both groups. participants and/or parents will be asked to complete a diary for 1 week and a questionnaire after every consultation: at baseline, after 6 weeks and after 12 weeks.


Eligibility criteria:
inclusion criteria: * children aged 4 years to 17 years * meeting the rome iv criteria for one of the four types of functional abdominal pain disorders (fapd's): functional dyspepsia, irritable bowel syndrome, abdominal migraine, functional abdominal pain - not otherwise specified. * being able to conduct a video consultation exclusion criteria: * if no follow-up consultation is indicated * if it is necessary that the follow-up consultations are face to face

Keywords: e-health video consultations children functional abdominal pain disorders
impact and utility of pet versus clinical score for the assessment of inflammatory activity in takayasu arteritis

Conditions: Takayasu Arteritis

Summary: the purpose of this study is to demonstrate that \[18f\]fdg pet is a a better method than clinical and laboratory values for the identification and assessment of inflammatory activity in patients with takayasu arteritis (ta), allowing long-term follow-up with a precise evaluation of response to therapy.

inflammatory activity and fibrosis are the main causes of morbidity and mortality in patients with takayasu arteritis. the investigators objective is to determine the utility of using 18f-fdg pet in the basal evaluation and follow-up of patients and compare the results with dabague's clinical score.

Eligibility criteria:
inclusion criteria: * ta was diagnosed if the patient met 3 or more acr criteria.
multi-dimensional prevention program after acute coronary syndrome (elips) (spum-acs- sp1)

Conditions: Acute Coronary Syndrome

Summary: to demonstrate the effectiveness of the elips programme (multi-dimensional prevention program after acute coronary syndrome), which aims at improving quality of care of patients admitted to hospital with acute coronary syndrome (acs) in the swiss setting. the program targets an increase in prescription rates by physicians and long term medication adherence and adoption of healthy lifestyle attitudes by patients. the program is dedicated to caregivers to increase their application of guidelines into practice, to increase their confidence in therapeutic education of patients, and to patients to improve their understanding of acs and its treatment and to increase their motivation for long term treatment,.


Eligibility criteria:
inclusion criteria: * patients \>18 years * admitted for an acs, that is with symptoms compatible with angina pectoris (chest pain, breathlessness) and at least one of the following 3 features : a) elevation or depression of the st segment, inverted t waves or dynamic changes in the repolarization phase b) positive troponin c) known coronary artery disease. a significant coronary artery disease must be confirmed angiographically. exclusion criteria: * severe physical disability or dement * less than 1 year of life expectancy for non cardiac reason
axi-cel retreatment in relapsed/refractory lbcl

Conditions: CAR-T Retreatment

Summary: this is a prospective, single-arm, clinical study to explore the efficacy and safety of axi-cel retreatment in r/r lbcl in shanghai ruijin hospital in china. r/r lbcl patients who treated with axi-cel got non-cr or relapsed were eligible for axi-cel retreatment in this study. patients will receive the standard dose of axi-cel and follow the standard process. other related treatment like bridging therapy or combination therapy will be based on patients status and investigators' decision. the primary endpoint is orr, the secondary endpoint is cr, pr, dor, pfs, os and ae. a total of 32 patients is planned to be enrolled in this study. the trial will not go on if nobody got cr or pr in first 6 patients.

this study is a prospective, single-arm, open-label two-stage study. there were 6 cases enrolled in phase 1 and 26 cases enrolled in phase 2, for a total of 32 cases. this study aimed to collect data on efficacy and safety after secondary infusion treatment with aquilencel in adult patients with r/r lbcl after the first treatment of cd19 car-t. no form of grouping was performed in this study, and subgroup analyses were performed based on the actual data collected. research process: the patient has been evaluated for disease after the first treatment of akilencel, and the investigator decided to give the patient a second treatment based on clinical practice. obtain informed consent before the second treatment of cd19 car-t, collect data on the patient's disease status before the second dose, previous and current decontamination treatment and other related treatments, and perform imaging tests such as positron emission tomography and computed tomography (pet-ct) or electronic computed tomography (ct) on the same day, day 15, day 29, month 3 after secondary administration, and 6, 9, 12, 18 and 24 months after secondary administration to confirm the collection of efficacy data, and investigators evaluated data on adverse events related to cd19 car-t, related laboratory results, etc.

Eligibility criteria:
inclusion criteria: 1. informed consent form (icf); 2. adults with diagnosed relapsed or refractory large b-cell lymphoma who have completed initial treatment with axi-cel; 3. non-cr or relapsed after the initial axi-cel infusion; 4. cd19 status by lymphoma lesion biopsy is at the discretion of investigators. 5. antidrug antibodies (ada) of axi-cel should be performed prior to retreatment. 6) lymphodepleting chemotherapy (fludarabine and cyclophosphamid) related toxicities were ≤ grade 1 or at the base line of axi-cel initial treatment. 8）no serious adverse events occurred during the initial axi-cel treatment or the adverse events in the first treatment period have recovered. exclusion criteria: 1. patients with hypersensitivity to any active ingredient or excipients (dimethyl sulfoxide, compound electrolyte injection, human albumin); 2. uncontrolled systemic fungal, bacterial, viral, or other infections

Keywords: axi-cel retreatment, r/r lbcl
prospective multicenter study to characterize the real-world evidence regarding safety and performance of the aspiration catheters family

Conditions: Thrombus in the Central and Peripheral Circulatory System, Including Saphenous Vein Grafts

Summary: the purpose of this post market study is to collect clinical data of the arthesys aspiration catheters family during percutaneous intervention and/or stenting procedure of vessels in the central and peripheral circulation system, including saphenous vein grafts, to support mdr submission.


Eligibility criteria:
inclusion criteria: * patients will be included as per instructions for use (ifu), hospital standard of care and good clinical practice (gcp): 1. patient with a percutaneous intervention to a native coronary, saphenous vein graft, or peripheral arteries; 2. patient with angiographic evidence of thrombus; 3. patient \> or = 50 kg; 4. patient \>18 years; 5. patient who understands the trial requirements and the treatment procedures and provides written informed consent. exclusion criteria: * patients will be excluded as per ifu, hospital standard of care and gcp, also if there are under judicial protection, guardianship or curatorship or if they are deprived of their liberty by judicial or administrative decision.
game plan for prep

Conditions: Human Immunodeficiency Virus Exposure; Alcohol; Harmful Use

Summary: this small pilot randomized controlled trial will test whether a brief, web-based intervention inspired by the principles of motivational interviewing helps high-risk men who take pre-exposure prophylaxis (prep) moderate their alcohol use, and improve key outcomes of prep care, including adherence, persistence, and sti rates. men with a history of "lapses" in prep adherence will be randomly assigned to either (1) use the web-based intervention, called game plan for prep, or (2) watch video clips encouraging healthy lifestyles (e.g., sleep hygiene, balanced diet; attention-matched control). participants will complete sti testing and submit dried blood spot (dbs) samples to facilitate analyses of alcohol use and prep adherence biomarkers at baseline, 3-months, and 6-months during the study period. participants will also complete online surveys at baseline, 1-month, 3-months, and 6-months during the study period.

this small, pilot randomized controlled trial will explore preliminary evidence for the efficacy of game plan for prep, a brief, web-based intervention inspired by brief motivational interventions. the study will test whether game plan for prep is efficacious in reducing heavy drinking and sexually-transmitted infection (sti) incidence, and improving prep adherence/persistence, among heavy drinking men who have sex with men who are on prep, but who report a recent history of missing 3 or more consecutive doses in the past month. in this study, we will randomize 50 gay and bisexual men to receive either (1) game plan for prep (gp4prep) or (2) an attention-matched control at the same prep care/monitoring visit that they reported meeting eligibility criteria. we will use self-report measures of alcohol use collected at 1-, 3-, and 6-months and changes in a biomarker of alcohol use collected at baseline, 3-, and 6-months to explore whether game plan for prep reduces binge drinking compared with control. we will also use data from a biomarker of prep adherence to explore whether game plan for prep improves prep adherence versus control.

Eligibility criteria:
inclusion criteria: * current male gender * 18+ years old * fluent in english * heavy alcohol use in the past month (\>5 drinks on a single occasion or \>14 drinks in a week) * currently prescribed and actively taking prep * report missing \> 3 prep doses in a row at least once in the past 3 months. exclusion criteria: * reporting a history or risk of complicated alcohol withdrawal * reporting currently receiving medications or counseling for an alcohol or drug use disorder * injection drug use in the past year * positive screen for drug-related disorders

Keywords: prep alcohol use hiv stis lgbtq
detection of coronary artery disease using analysis of high frequency qrs: the hyperq registry

Conditions: Coronary Artery Disease

Summary: this will be a registry study that will enroll patients referred for an ecg treadmill test with nuclear myocardial perfusion imaging (mpi). the high frequency qrs (hfqrs) information will be recorded and analyzed automatically and simultaneous with the standard ecg signals by the hyperq system. results of subsequent tests performed on each patient will be collected and used to enhance the reliability of designating each patient as a cad-negative (i.e., no significant coronary artery disease) or a cad-positive (i.e., significant coronary artery disease).


Eligibility criteria:
inclusion criteria: * 18 years or older * referred for exercise mpi due to suspected coronary artery disease exclusion criteria: * acute coronary syndrome (unstable angina/nstemi/stemi) * pre-excitation syndrome * qrs duration \> 120 ms * atrial fibrillation or significant ventricular arrhythmia * treatment with digoxin * pacemaker with 100% pacemaker dependence

Keywords: coronary artery disease high frequency qrs analysis ischemia exercise testing diagnosis of coronary artery disease
application of radiomics in precise preoperative diagnosis and prognsis evaluation of colorectal cancer.

Conditions: Colorectal Cancer Stage I-IV

Summary: this is a prospective, clinical study. this study is to collect and analyze data of radiomics of primary site or metastasis of colorectal cancer aiming to precisizing preoperative diagnosis and long-term prognsis evaluation.


Eligibility criteria:
inclusion criteria: * patients with pathologically confirmed colorectal cancer * male or female aged 18-75 years old on the day of signing informed consent. * patients who received imageological examination of primary or metastasis * patients who received surgical resection of primary or metastasis * patients must have a performance status of ≤1 on the ecog performance scale. * colorectal cancer is the only malignant tumor * written informed consent must be obtained from patient or patient's legal representative and ability for patient to comply with the requirements of the study exclusion criteria: * patients received adjuvant treatment prior to imageological examination * tis stage patients * paitents who diagnosed with malignant disease within 5 years. * patients with a history or current evidence of any condition or abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the investigator.
low dye taping technique and temporary felt insoles on pain and disability in children with pes planus.

Conditions: Pes Planus

Summary: this study aims to determine comparative effects of low dye taping technique and temporary felt insoles on pain and disability in children with pes planus.

pes planus is a foot arch deformity, is also known as flexible flat foot. foot arch plays an important role in cushioning ground impact and stabilizing the body in standing and walking. children with pes planus lack an elastic foot arch to attenuate the impact force. this condition results in pain and impaired lower limb function. low dye taping and shoe insoles are used to treat pes planus. low dye taping technique is designed to off-load the plantar fascia and provide medial ankle arch support. it is a classic taping method incorporating functional mechanical support of the foot and ankle. low-dye taping is commonly used to support the longitudinal and transverse arches of the foot. a shoe insole is the footbed or material inside the shoe that the bottom or plantar surface of your foot lays on. in most well-made shoes today, the material or insole is removable. there are shoes that have glued in insoles, however in general these are shoes that are not as well made. the removable insoles that come in most shoes vary in type and material ranging from very simple thin cushioning to sophisticated multiple layered arch support inserts. the aim of this study is to compare the effects of low dye taping and shoe insoles on pain and disability in children with pes planus. the study will be randomized clinical trial. total twenty four subjects will be assigned randomly by using block randomization into two groups (12 in each group). both groups will be experimental groups. group a will be given low dye taping and group b would be given temporary felt insoles. after confirmation of diagnosis with medical history and physical examination as well as different movement palpation tests and pain provocation tests are recommended. the foot and ankle ability measure (faam) and numeric pain rating scale (npr) would be used as an outcome measure tools for pain and disability respectively. measure will be taken at (baseline and at the end of treatment session). the collected data will be analyzed in statistical package for the social sciences (spss) 27.0. parametric/non-parametric tests will be applied after testing normality of data.

Eligibility criteria:
inclusion criteria: * 6-12year * vertical navicular height of 10 mm or more * a vernier height gauge (mitutoyo corp, tokyo, japan) calibrated to 0.02 mm was used to measure vertical navicular height. exclusion criteria: * current injuries to the lower extremities that had required a reduction in activity levels and/or treatment by a health-care practitioner. * severe orthopedic or neurologic conditions, and a known allergy to sports tape.

Keywords: disability insoles low dye taping pain pes planus
corneal topography in vernal keratoconjunctivitis

Conditions: Keratoconjunctivitis

Summary: to evaluate the corneal topographic changes in vkc patients using pentacam and prevalence of kc development in vkc.

vernal keratoconjunctivitis (vkc) is a chronic allergic disease, with seasonal periods of exacerbation.vkc is characterized by itching, photophobia. white mucous discharge, lacrimation, foreign body sensation, and pain due to corneal involvement of shield ulcers. corneal involvement in vkc involves injury to the superficial and basal epithelial layers and anterior stroma . excessive eye rubbing and a slow release of matrix metalloproteinases penetrate the cornea in presence of chronic epithelial damage causing astigmatism and corneal ectasia . these changes may be undetected until advanced complications such as keratoconus(kc) with thinning and protrusion of cornea leading to myopia and astigmatism . these changes can be measured accurately by corneal topography, making it the gold standard in the screening of keratoconus and other corneal ectasias . corneal topography is a method of computer-assisted examination of the cornea in which multiple concentric light rings are projected on cornea. changes in corneal topography indices to be studied include changes in effective refeactivepower ,asphericity , corneal asymmetry index and visual performance . it is a non-invasive exploratory technique to analyse both qualitatively and quantitatively the morphology of the cornea . the penta cam is a cornea and anterior segment topography device, based on a rotating scheimpflug camera. its optical cross-sectional analysis that helps in imaging of anterior and posterior corneal surfaces which provides with fullpachymetric map and many other data such as corneal aberrometry and densitometry that allow early detection of ectasia.

Eligibility criteria:
inclusion criteria: clinical diagnosis of vernal keratoconjunctivitis - exclusion criteria: patients with corneal disease as corneal opacity, corneal dystrophy or degenerative changes patients with previous corneal surgery patients with ocular trauma. -

Keywords: corneal topography on vkc