Kornimate/medical-research-clean huggingface dataset:
impact of music added to the usual treatment on the anxiety of patients undergoing outpatient cataract surgery with topical anesthesia

Conditions: Cataract Surgery; Anxiety

Summary: most patients treated for cataract surgery benefit from a short outpatient course with topical local anesthesia. having to undergo surgery, especially on the eye, without being asleep, can be stressful. sometimes waiting in a waiting room with other patients can increase this stress. patient anxiety may increase blood pressure potentially leading to the prescription of nicardipine to allow surgery to be performed. the patient's anxiety also increases the surgeon's stress, which can alter the conditions for performing the intervention and increase the risk of intraoperative complications. besides the administration of anxiolytics, nurses have few options for patients with anxiety. however, the treatment response time is not always appropriate and the patient's cooperation during the procedure can sometimes be impaired. the effect of music on preoperative anxiety has been evaluated in several studies and has shown a significant decrease in anxiety before surgery. musiccare® is a "digital treatment" based on the principles of hypnoanalgesia which has been tested in the management of patients with various pathologies (depression, alzheimer's disease, chronic pain, etc.) and has shown relative effectiveness. the absence of intervention on the pain and anxiety of patients. in the context of cataract surgery with topical local anesthesia, we would like to assess the contribution of offering the musiccare® listening device on patients' anxiety about absence


Eligibility criteria:
inclusion criteria: * first cataract surgery (first eye) * patient scheduled for short outpatient cataract surgery with topical anesthesia exclusion criteria: * pregnant or breastfeeding woman.

Keywords: cataract surgery anxiety musiccare music
monitoring ovarian cysts in pregnancy

Conditions: Ovarian Cysts

Summary: this prospective study will primarily aim to determine what monitoring is required of ovarian cysts when they are diagnosed in pregnancy, as well as what intervention, if any, is necessary. it also aims to identify the prevalence of ovarian cysts in pregnancy and the nature of these cysts, as well as their natural history throughout pregnancy.

the royal college of obstetricians and gynaecologists currently publish guidelines for the management of ovarian cysts in both pre and post-menopausal women. the guidelines for pre-menopausal women do not specifically include pregnant women, and it is known from previous research that the characteristics of ovarian cysts can differ in pregnancy, and therefore appear different on ultrasound scan. also, where intervention is needed, it is usually surgical which can have high risk implications in pregnancy. the study will be conducted in the early pregnancy and acute gynaecology unit at st. thomas' hospital. any woman who presents with symptoms in early pregnancy (less than 18 weeks) is offered a transvaginal ultrasound scan. if, on this scan, they are found to have an ovarian cyst, they will be considered for the study. once the ovarian cyst has initially been diagnosed, a confirmatory scan will be carried out by one of the investigators (ie. a clinical fellow, consultant gynaecologist or senior sonographer). if the cyst is benign in nature and not the cause of acute symptoms, three more transvaginal scans will be carried out by one of the investigators at approximately 12 weeks and 20 weeks (in line with the nuchal translucency scan and anomaly scan), then at 6 weeks post partum. it is intended that all these patients will be managed without surgical intervention. if there are concerns that the cyst is malignant, the participant would be investigated via the already established pathways. if the participant is at any point in acute pain and the cyst is thought to be the cause of this eg. ovarian torsion or cyst rupture, then a clinical decision would be made regarding surgical intervention. the total study period will be up to 16 months. this includes a 6 month recruitment period, then following up each participant until 6 weeks post delivery.

Eligibility criteria:
inclusion criteria: - age 16-50 pregnant scanned in the early pregnancy unit at st. thomas' hospital (either as a walk in patient / a ward in-patient / referred from a\&e or another speciality) at least one ovarian cyst (excluding a corpus luteum) exclusion criteria: - age \<16 (so as to avoid problems with consent / gillick competence) not pregnant (ie. attending the unit with acute gynaecology problem or for follow up after a miscarriage) lacks capacity to consent corpus luteal cyst only on ultrasound scan
millimeter wave therapy (mwt) for analgesia after total knee replacement

Conditions: Pain; Acute Pain

Summary: the aim of the study was to test whether the exposure to electromagnetic millimeter waves - millimeter wave therapy (mwt) is effective for relief of acute postoperative pain in patients after elective unilateral total knee arthroplasty (tka)


Eligibility criteria:
inclusion criteria: * patients with an american society of anesthesiologists physical status of ii or iii scheduled for elective tka * without previous opioid medication * patients 35-80 years old able to use pca pumps and visual analogue scale for pain intensity measurement * patients who have signed consent form exclusion criteria: * pregnant or nursing females * recidivist alcoholics * extremely obese patients (body mass index \> 35) * inability to operate pca-pump. * females with the history of unstable angina pectoris (s. risks for participants) * patients who are unable to understand the consent form * systemic infection * history of psychiatric disease * necessity to change postoperative analgesic scheme for particular patient * severe intercurrent disease during the course of mwt

Keywords: postoperative pain analgesia total knee arthroplasty
new biomarkers in auto-immune encephalitis and neurological paraneoplastic syndromes

Conditions: Paraneoplastic Neurological Syndrome; Autoimmune Encephalitis

Summary: autoimmune encephalitis (ae) and paraneoplastic neurological syndromes (pns) are rare neuroimmune syndromes with a wide range of clinical presentation but without pathognomonic clinical sign facilitating the diagnosis. a lot of differential diagnoses are possible such as neurodegenerative diseases or viral infections. although rare the diagnosis of ae or pns is essential because despite severe neurological symptoms, patients can be cured by appropriate immunotherapy. autoantibodies highly specific of ae and pns has been described in the serum and cerebrospinal fluid of the patients and can be used as biomarkers of the disease. their presence can predict an autoimmune origin and in many cases a good prognosis after immunotherapy. however, if some autoantibodies are now well-characterized and industrial kits have been developed to detect them, in numerous cases of highly suspect ae or pns no specific autoantibodies are identified leading frequently to an inappropriate treatment. furthermore, as the mechanisms of ae and pns is still unknown, treatments are not optimal and in some cases inefficient. there is no prognosis biomarker able to predict the patient's sensitivity to immunotherapy and there are only few clues to know how the immune system can provoke the neuropsychiatric symptoms observed in the patients. the investigators will use this project to better characterize ae and pns patients to identify new diagnostic and prognostic biomarkers and develop new diagnostic tools.


Eligibility criteria:
* inclusion criteria \* : * patient with neurological disorder * patient without antibody * exclusion criteria \* : * patient with characterized antibody * patient without neurological disorder

Keywords: paraneoplastic neurological syndrome autoimmune encephalitis
postoperative pain in neonates after abdominal surgery using quadratus lumborum block

Conditions: Postoperative Pain

Summary: postoperative pain scores and analgesic requirements will be evaluated in neonates after abdominal surgery, with regional quadratus lumborum block performed at the beginning of the procedure.


Eligibility criteria:
inclusion criteria: * abdominal surgery under general anesthesia * spontaneously breathing before the procedure exclusion criteria: * multiple organ failure * mechanical ventilation before the procedure

Keywords: pain neonate regional anesthesia postoperative
using continuous passive motion to prevent ankle problems in icu patients

Conditions: Joint Contracture; Mechanical Ventilation; ICU-acquired Weakness; Critical Illness; Muscle Atrophy

Summary: the goal of this clinical trial is to learn if continuous passive motion (cpm) helps prevent ankle joint contracture and muscle loss in critically ill, mechanically ventilated icu patients. it will also evaluate the feasibility and safety of implementing cpm in this population. the main questions it aims to answer are: does cpm help preserve ankle dorsiflexion range of motion during immobilization in the icu? can ultrasound measurements detect changes in tibialis anterior muscle condition in response to cpm? researchers will compare one ankle receiving cpm to the other ankle without intervention in the same patient to assess differences in joint mobility and muscle morphology. participants will: receive cpm therapy on one ankle for 30 minutes, twice daily, over a 7-day period or until icu discharge undergo goniometric and ultrasound assessments at baseline and at the end of the intervention remain under usual icu care and monitoring while enrolled in the study


Eligibility criteria:
inclusion criteria: * adults aged ≥ 18 years * admitted to the icu with acute respiratory failure requiring mechanical ventilation * expected to remain mechanically ventilated for at least 7 days * sedated and unable to participate in active mobilization * no contraindications for passive ankle movement * informed consent obtained from legal representative exclusion criteria: * pre-existing neuromuscular disorders affecting lower limb mobility (e.g., stroke with hemiparesis, myasthenia gravis) * recent orthopedic surgery or trauma involving the lower limbs * presence of lower limb amputation * peripheral vascular disease with critical limb ischemia * active deep vein thrombosis in either leg * significant wounds, pressure ulcers, or skin breakdown at the heel * pregnancy

Keywords: continuous passive motion ankle joint contracture icu-acquired weakness mechanical ventilation ultrasound muscle assessment critical illness rehabilitation
effectiveness of docusate in preventing/treating constipation in palliative care patients

Conditions: Constipation; Palliative Care

Summary: the purpose of this study is to determine if docusate is effective in the treatment of constipation in palliative care patients.

palliative patients frequently experience constipation due to multiple factors - structural abnormalities, medications, metabolic disturbances, neurological disorders, and other general conditions. docusate is a stool softener that has been widely used, in combination with other stimulating laxatives, to prevent and treat constipation in palliative care patients. in the past decade there has been controversy about its effectiveness in these populations, but no controlled trials have been conducted on the use of docusate in palliative patients. the purpose of this study is to assess the effectiveness of docusate in preventing and treating constipation in palliative care patients. the study design is a randomized, double-blind, placebo-controlled trial to compare the current standard treatment (docusate in combination with a laxative, sennoside) to that of a sennoside laxative alone. a total of 70 patients (35 in each group) will be recruited from the palliative care unit at st. joseph's auxiliary care hospital, the mel miller hospice at the edmonton general continuing care hospital, and capitalcare norwood in edmonton, alberta, canada. patients must be ≥ 18 years of age, able to take oral medication, without difficulty swallowing, have a palliative performance ≥ 20%, and do not have a stoma. the duration of treatment will be for 10 days. the main outcome measures will include bowel frequency, stool consistency, other interventions (suppositories, enemas), difficulty defecating, and sense of inability to evacuate completely. this study will provide insight into the effectiveness of docusate in preventing and treating constipation in palliative patients who are cared for by family physicians and specialized palliative care providers. if docusate is found to have no added benefit,it has the potential to enhance the quality of life for palliative care patients by reducing the number of medications taken and reducing the palliative care team's (e.g. nursing) workload and cost.

Eligibility criteria:
inclusion criteria: * greater than or equal to 18 years of age * new admissions * able to take oral medications * patient and/or personal directive agent (proxy) provides written consent * does not have a stoma * no difficulty swallowing * no previous intolerance/contraindications to docusate * palliative performance greater than or equal to 20% exclusion criteria: * less than 18 years of age * failing to provide consent * unable to take oral medication/difficulty swallowing * previous intolerance/contraindications to docusate (colace) * patients who have a stoma * palliative performance status \< 20%

Keywords: docusate constipation colace palliative care sennoside senokot terminally ill stool randomized trial
study of tranexamic acid for the reduction of blood loss in patients undergoing major abdominal surgery

Conditions: Biliary Tract Surgical Procedures; Pancreaticoduodenectomy; Esophagectomy; Colectomy; Gastrectomy

Summary: tranexamic acid has been shown to reduce postoperative blood losses and transfusion requirements in various types of major surgery (orthopedic surgery, spine surgery, cardiopulmonary bypass, liver resections, and gynecological cancers).the current trial is being conducted to compare the efficacy of tranexamic acid plus standard of care versus standard of care in reduction of blood loss in patients undergoing major abdominal surgeries.


Eligibility criteria:
inclusion criteria: * patient undergoing major abdominal surgery (biliary strictures, pancreatico-duodenectomy, esophagectomy, total proctocolectomy, hemicolectomy, gastrectomy, other major abdominal surgeries with similar expected blood loss) exclusion criteria: * patients with a platelet count less than 100, 000/mm3 or history of thrombocytopenia. * patients with known coagulopathy. * patients with anemia (hemoglobin levels less than 8 mg/dl) * patients with documented dvt or pe at screening or in past three months. * patients with any associated major illness (e.g., severe cardiac or respiratory disease). * anticoagulants (other than lmwh or heparin in prophylactic doses to prevent deep vein thrombosis), direct thrombin inhibitors or thrombolytic therapy administered or completed within last week

Keywords: tranexamic acid major abdominal surgery blood loss
low intensity extracorporeal shockwave therapy for patients with erectile dysfunction

Conditions: Vasculogenic Erectile Dysfunction

Summary: this is a prospective, pilot study for assessing the safety and efficacy of the treatments performed with renova (li-eswt) on symptomatic ed patients.


Eligibility criteria:
inclusion criteria: * good general health * vasculogenic ed for at least 6 months * international index of erectile function 6 (iief-ef) between 11 to 25 * positive response to pde5-i (able to penetrate on demand, responders) * negative response to pde5-i (unable to penetrate on demand even with maximum pde5-i dosage,non-responders) * stable heterosexual relationship for more than 3 months exclusion criteria: * psychogenic ed * neurological pathology * hormonal pathology * past radical prostatectomy * recovering from cancer during last 5 years * any unstable medical, psychiatric, spinal cord injury and penile anatomical - abnormalities * clinically significant chronic hematological disease * anti-androgens, oral or injectable androgens * radiotherapy in pelvic region

Keywords: low intensity shockwave extracorporeal shockwave therapy erectile dysfunction
hepatitis c education for pregnant women with opiate addiction - phase 1

Conditions: Hepatitis C

Summary: the goal of this study is to assess the health literacy level of patients enrolled in the hope program, identify any gaps in their knowledge of hepatitis c, analyze the variables that may influence patients' knowledge, and educate patients on hepatitis c.

the study will compare the effectiveness of providing a pamphlet and expert education compared to providing a pamphlet only. the information gained in completing this study will help the medical community improve patient education on the disease and specifically understand how the medical community can best serve pregnant patients with opiate dependence burdened by hepatitis c.

Eligibility criteria:
inclusion criteria * the study will include patients with and without hepatitis c diagnosis. * patients will be recruited at their routine prenatal and post-partum visits. * patients who speak and understand english exclusion criteria: * patients under the age of the 18 years
deployment o the multidisciplinary prospective cohort imminent

Conditions: Chronic Inflammatory Disease; Angioedema; Severe Asthma; Lupus; Atopic Dermatitis; Psoriatic Arthritis; Multiple Sclerosis; Systemic Sclerosis; Behçet Disease

Summary: immune-mediated inflammatory diseases (imids) most often affect young patients and have high impact on morbidity and mortality with a significant alteration in the quality of life of patients with professional, social and emotional repercussions. beyond this burden, imids share many common pathophysiological mechanisms and treatments, known as "targeted therapies". despite progress in this field, much remains to be done in clinical, therapeutic and fundamental research to address the efficacy, resistance and side-effects of treatment. these similarities between imids have led the fhu imminent to propose the creation of a prospective, multidisciplinary clinical-biological database (imminent cohort), associated to a biobank, of patients with imids. the main objectives of this database will be to identify new prognostic and therapeutic biomarkers in order to develop new therapeutic targets and biomarkers, to identify prognostic factors and determinants related to the activity, severity and quality of life of patients with imids as well as to the response and tolerance to treatment.


Eligibility criteria:
inclusion criteria: * patient followed for their imid in one of the departments of the lille university hospital participating in the study (dermatology, internal medicine, neurology, pneumology and rheumatology) * social insured * have the capacity to understand the study requirements, provide written informed consent, and comply with the study data collection procedures. exclusion criteria: * administrative reasons: inability to receive informed information, inability to participate in the entire study, lack of coverage by the social security system. * pregnant or breastfeeding woman * persons deprived of liberty * protected minors or adults * persons who have refused or are incapable of giving informed consent * persons in emergency situations

Keywords: immune mediated inflammatory diseases (imids) biomarker cohort study quality of life disease severity
clinical evaluation on ha coated dynamic hip screws for trochanteric femoral fractures

Conditions: Osteoarthritis

Summary: evaluated whether ha coated dynamic hip screws can improve the surgical results in trochanteric femoral fractures

randomised study to determine the effect of ha coating on the stability of lag screws used to reduce femoral neck fractures. stability of the screw will be determined by rsa measurements. the effect of the ha coating on bone remodeling will be determined by dexa measurements

Eligibility criteria:
inclusion criteria: * patients with trochanteric femoral fractures exclusion criteria:
a pilot study of human amniotic fluid for covid19 associated respiratory failure

Conditions: SARS CoV-2 Infection

Summary: the purpose of this study is to test the effect of purified (acellular) amniotic fluid as a treatment for sars cov-2 (covid19)-associated respiratory failure. past use of human amniotic products (i.e., membrane and fluid) is fda-approved for tissue injury and has been used to reduce inflammation and fibrosis in patients with a variety of medical conditions. the investigators hypothesize that using nebulized and/or intravenous purified (acellular) amniotic fluid will reduce both inflammation in patients hospitalized for in sars cov-2 (covid19)-associated respiratory failure, potentially leading to a decrease in respiratory support.


Eligibility criteria:
inclusion criteria: * 1. age ≥18 * 2. hospitalized and symptomatic (cough, fevers, sob, or sputum production) * 3. sars cov-2 laboratory positive obtained within 14 days of enrollment exclusion criteria: * 1. none

Keywords: amniotic fluid respiratory failure critical illness
feasibility, safety and efficacy of remote ischemic preconditioning for symptomatic intracranial arterial stenosis in octogenarians

Conditions: Bilateral Limb Ischemic Preconditioning; Intracranial Arterial Stenosis

Summary: making a limb transiently ischemic induces ischemic tolerance in distant organs such as the heart. this study aims to evaluate the feasibility, safety and initial efficacy of using briefly repetitive bilateral limb ischemic preconditioning (blipc) to protect the brain in octogenarians with symptomatic intracranial arterial stenosis.


Eligibility criteria:
inclusion criteria: 1. age between 80 to 95 years old 2. trial of org 10172 in acute stroke treatment-1 (toast-1) subtype 3. national institutes of health stroke scale (nihss) score 0-15, and modified rankin scale (mrs) score 0-4 4. abcd2 score between 6 to 7 5. stable vital signs, normal hepatic and renal functions 6. no hemorrhagic tendencies exclusion criteria: 1. within 72 hrs of intra-artery or intravenous thrombolysis 2. intracranial hemorrhage or large area of cerebral infarction (more than 1/3 middle cerebral artery perfusion territory) 3. any soft tissue, orthopedic, or vascular injury, wounds or fractures in extremities which may pose a contraindication for application of the preconditioning cuffs 4. acute myocardial infarction 5. systolic blood pressure more than 200 mmhg after drug control 6. peripheral blood vessel disease 7. hematologic disease 8. severe hepatic and renal dysfunction 9. severe or unstable concomitant disease 10. cannot tolerate blipc or without informed consent

Keywords: remote ischemic preconditioning octogenarian intracranial arterial stenosis stroke recurrence