Kornimate/medical-research-clean huggingface dataset:
thyroid function , hba1c in relation to ferritin level in adullt patient e b thalassemia

Conditions: B Thalassemia

Summary: to evaluate thyroid function ,hba1c,\&lipid profile in thalassemic patient to correlate thyroid function , hba1c , lipid profile e ferritin level in thalassemic patient

b-thalassemia major (b-tm) is a hereditary ،anemia resulting from defects in the production of b-globin chains and is one of the most common genetic disorders worldwide. the clinical classification of thalassemias is currently widely applied in clinical practice related to transfusion requirements transfusion-dependent thalassemia (tdt) is defined as a condition where patients cannot produce adequate hemoglobin to survive without blood transfusion. non-transfusion-dependent thalassemia (ntdt) is a descriptive term for patients who do not require regular lifelong transfusions. they may require intermittent or frequent transfusions in certain clinical situations. patients with β-thalassemia intermedia have symptoms in between carriers and those with β-thalassemia major. endocrine complications are the commonest among btm patients and the attributing factor is iron deposition in endocrine organs due to frequent blood transfusions along with suboptimal iron chelation. thus, keeping an iron level within the useful and safe range is critical since a low amount can cause anemia, while a high level can cause tissue damage background pathophysiologic mechanism leading to dm in tm is unclear; some regard the iron induced pancreas cytotoxicity as the most significant contributor, a new hypothesis suggests the exhaustion of beta pancreatic cells subsequent to a chronic period of hyperinsulinemia .there are 5% of thalassemia patients develop clinical hypothyroidism that requires treatment, a bigger number of them develop subclinical compensated hypothyroidism with normal t3 and t4 levels but high tsh serum levels. the tdt is also associated with altered lipid levels because of oxidative stress that can lead to early atherosclerosis, adding to the morbidity and even early mortality.

Eligibility criteria:
inclusion criteria: * patient aged18 and older * both gender * patient diagnosed b thalassemia major * patient diagnosed b thalassemia intermediate exclusion criteria: * thalaasemia trait * age less than 18 * type 1 d.m * pt known thyroid \&recive tttt
study of asthma in patients of african descent

Conditions: Asthma

Summary: this study will last up to 62 weeks. you will visit the clinic up to 17 times. certain clinic visits will include physical examination, medical history review and lung function tests. the purpose of this study is to see if one asthma drug (fluticasone propionate/salmeterol) is better in reducing the number of asthma exacerbations compared with another drug (fluticasone propionate alone)


Eligibility criteria:
inclusion criteria: * history of asthma for at least 6 months. * taking a low-dose of an inhaled corticosteroid for at least one month prior to the study (such as fluticasone propionate or budesonide). exclusion criteria: * history of life-threatening asthma. * hospitalized for asthma within 3 months prior to the study. * current respiratory tract infection. * will not be able to attend clinic visits for the entire length of the study. * certain medical conditions that will make being in the study unsafe (such as congestive heart failure, uncontrolled hypertension, tuberculosis or certain drug allergies).

Keywords: asthma exacerbation asthma
the effect of eye care with artificial tears and normal saline on ocular surface disease in mechanically ventilated pediatric patients

Conditions: Ocular Surface Disease

Summary: the primary aim of this study is to comparatively examine the effects of eye care practices using artificial tears and normal saline on superficial ocular injuries in pediatric patients receiving mechanical ventilation in the intensive care unit. based on the findings, the study seeks to provide evidence-based contributions to nursing practices. additionally, it aims to identify educational strategies to enhance intensive care nurses' knowledge and practice levels and to support the development of clinical care protocols. h0: there is no difference in the effect of eye care with normal saline and artificial tears on superficial ocular injury in mechanically ventilated pediatric patients. h1:eye care with normal saline is more effective than artificial tears in preventing superficial ocular injury in mechanically ventilated pediatric patients. h2: eye care with artificial tears is more effective than normal saline in preventing superficial ocular injury in mechanically ventilated pediatric patients.


Eligibility criteria:
inclusion criteria: * patients aged 28 days to 18 years * receiving invasive mechanical ventilation * admitted to the pediatric intensive care unit * parent(s) or legal guardian(s) provide informed consent for participation exclusion criteria: -having eye-related disease

Keywords: ocular surface disease eye care pediatric intensive care nursing artificial tears saline
study to evaluate the efficacy and safety of balovaptan in adults with post-traumatic stress disorder (ptsd)

Conditions: Stress Disorders, Post-Traumatic

Summary: this study will evaluate the efficacy and safety of 10 mg of oral administration balovaptan once a day (qd) compared with matching placebo in adults with ptsd.


Eligibility criteria:
inclusion criteria: * participants who have a current diagnosis of ptsd as per dsm-5 criteria, with a score of \>/=33 on the pcl-5 at screening * the index trauma event must have occurred in adulthood, i.e., when the participant was \>/=18 years old * the index trauma event must have occurred at least 6 months prior to screening and no more than 10 years prior to screening * at baseline, either taking a stable dose of a single antidepressant (ssri or snri) for management of ptsd and have been on that medication for \>/=6 weeks at that stable dosage and demonstrating residual symptoms of ptsd or prior demonstrated lack of tolerability or lack of efficacy and not taking an antidepressant medication at baseline for \>/=6 weeks * treatment with permitted medications and/or non-pharmacological interventions at a stable dose for 6 weeks prior to screening * for women of childbearing potential: agreement to remain abstinent or use contraception exclusion criteria: * participants who are experiencing ongoing exposure to traumatic events within 3 months of screening * participants who are pregnant or breastfeeding, or intending to become pregnant during the study or within 14 days after the final dose of study drug * clinically significant psychiatric and/or neurological conditions, which may interfere with the assessment of safety or efficacy endpoints * substance use disorders during last 12 months * significant risk for suicidal behaviour * epilepsy or seizure disorder considered not well controlled within the past 6 months or changes in anticonvulsive therapy within the last 6 months * clinical diagnosis of peripheral neuropathy * within the last 2 years, unstable or clinically significant cardiovascular disorders * positive serology results for hepatitis b surface antigen (hbsag), hepatitis c virus (hcv) antibody, or human immunodeficiency virus (hiv) 1 or 2 * moderate or severe hepatic or renal impairment * history of coagulopathies, bleeding disorders, blood dyscrasias, hematological malignancies, myelosuppression (including iatrogenic) * medical history of malignancy, if not considered cured * participants who have received treatment with investigational therapy within 8 weeks prior to randomization * known hypersensitivity to balovaptan, its components, or any of the excipients used in the formulation
effect of u=u messaging on hiv in south africa

Conditions: HIV/AIDS

Summary: this cluster randomized trial will investigate whether messaging about being undetectable equals untransmittable (u=u) designed through a participatory, user-centered approach increases hiv testing uptake within men in klipfontein mitchells plain (kmp) district in cape town, south africa.

this study will investigate the effect of participatory, user designed messaging to increase knowledge about u=u on hiv testing uptake within men in the klipfontein mitchells plain (kmp) district, a resource-limited, densely populated, high hiv disease burden area in cape town, through a cluster randomized trial design. the study will be conducted in two phases: phase 1 is a participatory, human-centered design framework will be used to develop u=u messages to increase hiv testing uptake in men. phase 2 is a cluster randomized trial that will determine the effect of u=u messaging on hiv testing uptake. the primary outcome will be hiv testing uptake at a community-based mobile clinic. secondary outcomes will include the proportion of males tested who are hiv-positive (and newly hiv positive). men in the intervention group will receive invitation cards for mobile hiv testing that contain u=u messages. men in the control group will receive invitation cards for mobile hiv testing that contain standard messaging. mobile clinic days (i.e. clusters of men receiving invitation cards on a single day) will be the unit of randomization. recruitment will be conducted by trained mobile clinic staff at high foot-traffic sites in the kmp community. recruitment efforts will be focus on young men in multiple mobile testing sites that are located in areas within kmp.

Eligibility criteria:
inclusion criteria: * men at least 18 years of age within the vicinity of the mobile tutu tester hiv testing mobile clinic exclusion criteria: * none

Keywords: behavioral sciences hiv testing
therapy with verapamil or carvedilol in chronic heart failure

Conditions: Dilated Cardiomyopathy

Summary: the aim of this study is to compare the effect of treatment with verapamil or carvedilol on long-term outcomes in stable, chronic heart failure secondary to non-ischemic cardiomyopathy.

heart failure, irrespective of its etiology may be viewed as a progressive disorder initiated by a different events and sustained by a multifaceted pathophysiological mechanisms. regardless of the nature of the initiating events and optimized therapy used, loss of functioning cardiac myocytes developed and the disease progressed. one potential explanation for such progression is that not all pathological mechanisms underlying the disease are antagonized enough by currently used therapeutic strategy. accordingly, impaired myocardial perfusion secondary to microvascular dysfunction has been postulated to play a major role in the progression of heart failure despite standard therapy for heart failure. it has been hypothesized that diffuse subendocardial ischemia due to altered coronary physiology may contribute to the global cardiac dysfunction seen in heart failure patients. accordingly, coronary endothelial dysfunction at the microvascular and epicardial level in patients with acute-onset idiopathic dilated cardiomyopathy and chronic congestive heart failure has been reported. thus, taking all mentioned above into account, the improvement in endothelial function and diminishing of subendocardial ischemia with calcium antagonists may be promising in terms of using these drugs for therapy of patients with stable chronic heart failure. the previous randomized study (5) and our long-term pilot study support this point of view.

Eligibility criteria:
inclusion criteria: * chronic heart failure (nyha ii and iii; lv ejection fraction, ≤ 35%) secondary to non-ischemic cardiomyopathy * stable condition at least 6 months before enrollment on conventional therapy (beta-blockers, ace inhibitors and diuretics). exclusion criteria: * improvement in clinical status on conventional therapy in out-patients period preceded hospitalization, * any changes narrowing epicardial coronary arteries in coronary angiography, * insulin dependent diabetes, * valvular heart disease (except the relative mitral regurgitation), * endocrine disease * significant renal and liver disease * alcohol abuse * lack of written informed consent

Keywords: dilated cardiomyopathy heart failure
implementation strategy and systemic effects of routine telemedical care in prehospital emergency medicine

Conditions: Telemedicine Usage; Teleconsultation Usage; Emergency Medical Service Missions

Summary: in two research projects a comprehensive prehospital telemedicine system was developed and general feasibility as well as impact on guideline adherence were evaluated. these results allowed stepwise implementation into medical routine care. all steps and milestones from the research idea to implementation were analyzed and evaluated descriptively in this study. using a pre-post intervention analysis the systemic effects of the implementation on change in emergency medical resource utilization were analyzed.

in two interdisciplinary research projects a comprehensive prehospital telemedicine system was developed and general feasibility as well as impact on guideline adherence were evaluated. feasibility and general safety were demonstrated. these results allowed stepwise implementation into medical routine care during a one year phase. during implementation positive effects on guideline adherence were found. despite positive results there are many barriers that prevent implementation of research projects into routine medical care. therefore, the current study evaluated and interpreted all steps and milestones from the research idea to implementation and evaluated them descriptively. using a pre-post intervention analysis the systemic effects of the implementation on change in emergency medical resource utilization were analyzed. resource utilization of physician staffed emergency medical service units was compared between a pre-implementation period (12 months, april 2013 - march 2014) and a post-implementation period (12 months, april 2015 - march 2016). during the pre-implementation period only standard care was available. inclusion criteria: all emergency medical service (ems) missions in both periods. data sources: electronic health records of the ems missions (data pseudonymity) and database of the regional ems dispatch center.

Eligibility criteria:
inclusion criteria: all patients treated by emergency medical service during the pre- and post-implementation period. post-implementation period: patients had to give verbal consent prior to teleconsultation. exclusion criteria: pre-implementation period: none post-implementation period: patients who refused teleconsultation.

Keywords: telemedicine emergency medical service
tamsulosin phase iii clinical trial -double-blind, placebo controlled study in female patients with lower urinary tract syndrome

Conditions: Urinary Tract Diseases

Summary: the purpose of this study is to determine whether tamuslosin is effective in the treatment of lower urinary tract syndrome with female patients.


Eligibility criteria:
inclusion criteria: * patients with urination disorder not accompanied by apparent organic or neurologic abnormality(lower urinary tract syndrome: luts)． exclusion criteria: * patients with urination disorder accompanied by apparent organic or neurologic abnormality, active urinary tract infections, severe cardiovascular, hepatic and/or kidney complications.

Keywords: tamsulosin urinary tract diseases female
improved medically assisted procreation monitoring

Conditions: Infertility

Summary: patient care in medically assisted procreation (map) requires a close and regular monitoring of the evolution of the estradiol rate. this monitoring allows the dose and duration of treatment to be accurately adjusted for each woman (every 24 or 48 hours) up to 10 to 15 days of treatment with gonadotrophins. oestradiol (e2) is secreted by the growing ovarian follicles and reflects their growth and maturity. its plasma dosage makes it possible to monitor the ovarian response to stimulation. this monitoring involves several constraints amongst which disruption of work life, stress, fatigue that can alter the response to treatment

in order to improve the comfort of patients already under severe stress, simplification of this monitoring is proposed. the development of an immediate-release whole blood test for simplified monitoring of estradiol levels will provide considerable comfort in the management of patients. these patients are subjected to significant emotional and physical stress and the development of this test will reduce the negative consequences that result.

Eligibility criteria:
inclusion criteria: * women over 18 years old * patient followed for monitoring of ovarian stimulation; * having received information on the protocol and given consent to participate exclusion criteria: * adult under safeguard of justice, guardianship or curatorship * persons deprived of liberty.

Keywords: ovarian stimulation blood test medically assisted procreation
music therapy and bio-psychological effect among chronic psychiatric inpatients of a community teaching hospital

Conditions: Chronic Psychosis

Summary: negative symptoms are an important factor in preventing patients from returning to the community, we aim to assess the effect of music therapy on negative symptoms through this study. participants of integrated music therapy will receive instrument playing, singing, lyrics modification/music organized play, listening to music and discussing each treatment process. other participants will receive passive music listening or regular occupational therapy during the experimental period. psychiatric symptoms, quality of life, social and interactive skills, and the differences in the physiological signals produced by skin, muscles, and heart will be measured before, after, and two months after the music therapy.

music therapy is gradually being used in the field of psychiatry, such as depression, anxiety, and development disorders in children. however, music therapy still lacks systematic research on chronic mental illness. since negative symptoms are an important factor in preventing patients from returning to the community, we aim to assess the effect of music therapy on negative symptoms through this study. additionally, taiwan as many asian countries have not yet established a certification system for music therapy. this study cooperates with licensed therapists abroad in the hope of promoting the systematic development of local music therapy in the future. participants of integrated music therapy (group 1, integration of active and passive music therapy) includes instrument playing, singing, lyrics modification/music organized play, listening to music and discussing each treatment process. the four stages of activities are warm-up, main activities, secondary activities, and the ending section. the participants of the music listening group (group 2, background music listening), music selection based on the musical preference and background of subjects, for relax or boost the spirit of the subjects. participants in the control group (group 3) receive their regular occupational therapy during the experimental period. we plan to recruit 100 people in the wards: 40/20/40 (group 1/2/3) under random assignment. to evaluate the effects of three groups, we measure their psychiatric symptoms, quality of life, social and interactive skills, and the differences in the physiological signals produced by skin, muscles, and heart assisted by a medical engineering scholar before, after, and two months after the music therapy.

Eligibility criteria:
inclusion criteria * chronic patient in rehabilitation ward without compulsory hospitalization. * patients with mental, behavioral and neurodevelopmental disorders, including schizophrenia, schizotypal personality disorders, delusional disorders, affective disorders, and organic mental disorders. exclusion criteria * patients with hearing impairments. * patients with no capacity to make juridical acts.

Keywords: music therapy chronic psychosis negative symptoms occupational therapy biosignal analysis
developing an interdisciplinary pharmacogenomic treatment approach to reduce medication burden and improve outcomes

Conditions: Developmental Disabilities

Summary: there is no common rule as to how a drug will affect patients. this is due to the effect specific dna sequences of genes have on drug response, by the effect they have on how medications are metabolized. the primary objective of this research is to optimize medication therapy and to reduce the number of medications used, specifically medications for people with developmental disabilities and co-occuring psychiatric illnesses.

the primary goal of this study is to develop a process for utilizing pharmacogenomic analysis as a strategy to improve the quality of life, safety, decrease medication burden, and enhance the effectiveness of medications in people with psychiatric illnesses and developmental disabilities. ultimately, this inter-disciplinary service could be developed into a standard screening and consultation tool for healthcare providers to utilize when determining the most appropriate medication for their patients.

Eligibility criteria:
inclusion criteria: * current resident of the south dakota developmental center (sddc) * currently taking a high number of medications per month * eligibility of the subjects will be determined by the treatment team which consists of 3-4 of the following individuals: treating psychologist, behavior therapist, case manager, supervisors, counselors, dietitians, physician assistants, occupational therapists, and physical therapists exclusion criteria: * to be determined by the research staff

Keywords: psychiatry psychiatric illness developmental disability mental health medication burden