Kornimate/medical-research-clean huggingface dataset:
dexamethasone in prevention of respiratory morbidity in elective caesarean section in term fetus

Conditions: Transient Tachypnea of the Newborn

Summary: introduction: babies born at term by elective caesarean section (cs) and before onset of labor are more likely to develop respiratory complications than babies born vaginally. in developing countries resources are scarce and it is difficult to provide expensive treatments as neonatal care. aim of the work: to assess the effect of prophylactic dexamethasone administration before elective cesarean section at term in reducing neonatal respiratory complications. patients and methods: 600 women were included in the study and were planned to have elective caesarean section. 300 received dexamethasone 12 mg twice, 12 hours apart 48 hours before delivery. 300 patients were the control group. the outcomes were: incidence of admission to neonatal intensive care unit (nicu), incidence of transient tachypnea of newborn (ttn), the incidence of respiratory distress syndrome (rds) and the need for mechanical ventilation.

dexamethasone which is a long acting corticosteroid can be used prior to elective cesarean section to decrease neonatal respiratory morbidity by enhacing fetal lung maturity.

Eligibility criteria:
inclusion criteria: * previous caesarean section * complete 37 week calculated from the first day of the last menstrual period. exclusion criteria: * obstetric complications such as pre-eclampsia, antepartum hemorrhage or known fetal anomaly. * hypertensive patients. * chronic disease e.g. diabetes mellitus. * known renal disease. * pre-operative infection.

Keywords: dexamethasone, term, elective cesarean section
the effect of awareness on preoperative anxiety

Conditions: Anxiety; Anesthesia

Summary: in the majority of patients, anxiety and fear are observed at different levels before surgery. preoperative anxiety was reported in 60-80% of the patients who underwent surgery. this anxiety and fear can be attributed to many factors. some of these are mainly anesthesia, previous experience of the patient, personality traits, concerns about surgical intervention, and postoperative pain. patients' anxiety levels can be influenced by a variety of factors, including previous experience, type of hospital arrival, sex, age, and type of surgery.anesthesia-related awareness among the experiences of anesthesia is described in the literature. in a study of 20,402 patients in the united states, the awareness rate was 0.13%. being aware is that the patient is awake during the surgery and recalls seeing bad dreams. at that time the patient could not specify this because he was immobile. being awake is that the patient is awake and showing it through his movements. the patient may not remember this situation later. it is a condition that can always be overlooked in previous experience, which is an important parameter of anxiety in the preoperative period. the patients included in the study were planned to use the modified brice awareness score, first mentioned in 1970 as the name of the person who used the anesthesia and anesthesia for awareness. in this study, investigators aim to reveal the effect of anesthesia awareness on preoperative anxiety in patients with previous anesthesia story.

in this study will include 300 patients. 300 patients will be enrolled in the anesthesia outpatient clinic scheduled for elective surgery for any reason at the age of 18-65 years. patients with dementia and psychiatric disorders, anxiolytic and psychiatric drug users and patients who can not receive written approval will be excluded from the study.

Eligibility criteria:
inclusion criteria: * all patients between 18-70 yr exclusion criteria: * dementia * psychiatric disorders * using antipsychotic
effects of hand massage after cesarean section

Conditions: Primiparous Mothers Who Gave Birth by Cesarean Section

Summary: h1-1 hypothesis: hand massage applied after cesarean delivery has an effect on reducing the level of pain in the cesarean section incision area of women. h1-2 hypothesis: hand massage applied after cesarean delivery has an effect on increasing the comfort scale score of women. h1-3 hypothesis: hand massage applied after cesarean delivery has an effect on reducing the time of gas production in women.


Eligibility criteria:
inclusion criteria: having primiparous pregnancy, * 18 years old and over, * able to speak turkish and express himself in turkish, * does not have any disability (such as vision, hearing) * having completed the 6th hour after cesarean delivery, hospitalized in the gynecology service, * having undergone cesarean section with spinal anesthesia, * having no findings such as wounds, nerve problems, history of surgery or amputation on their hands, * single pregnancy, * women who are open to communication and who are mentally and physically healty exclusion criteria: not accepting to work, * having a gas outlet before starting the application, * presence of findings such as wounds on hands, nerve problems, history of surgery or amputation, * having postpartum hemorrhage, * with uterine subinvolution, * having a cesarean section with another type of anesthesia other than spinal anesthesia (such as general, epidural combined) * having twin babies, * having a premature baby (the baby needs more attention and care) * women whose babies are hospitalized in the neonatal intensive care unit.

Keywords: hand massage cesarean delivery ache comfort gas outlet midwife
dermacyd ph_detinback (lactic acid) sweet flower - compatibility

Conditions: Hygiene

Summary: the purpose of this study is to demonstrate the absence of irritation potential (primary dermical irritability and cumulated dermical irritability) and allergy (sensibilization) of the product dermacyd phdetinback sweet flower.


Eligibility criteria:
inclusion criteria: phototype skin i,ii, iii e iv * integral skin test in the region; * willingness in following the study procedures and to be present in the clinic at the days and scheduled time for medical evaluations and for application of occlusion; exclusion criteria: * lactation or gestation * use of antiinflammatory and/or immunosuppression drugs * personnel history of atopy; * history of sensitivity or irritation for topic products; * active cutaneous disease; * use of new drugs or cosmetics during the study the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
a comparison of two urinary catheters of different lengths for female use, in intermittent catheterization

Conditions: Catheterization

Summary: a study comparing a 10 cm catheter with a 7 cm catheter in a group of female patients who, on a routine bases, empty their bladder using urinary catheters, by measuring residual urine after intermittent catheterization.

the study personnel will conduct three bladder scans after each catheterization in order to obtain the mean residual urine volume. each patient will catheterize herself two times with each product, i.e. a total of four catheterizations. diagnosis and bmi will be collected at visit 1 to assess whether the residual urine volume differs between these subgroups. the hypothesis that the mean residual volumes were equal when using the 7 and the 10 centimeter catheters was tested by means of the wilcoxon signed rank test.

Eligibility criteria:
inclusion criteria: * provision of signed informed consent * female subjects aged 18 years and over * experienced users of cic with a minimum of one month of use * practice cic a minimum of 1 time per day * practice cic with female catheters with a maximum length of 20 cm * perform self-catheterization * sufficient hand function to be able to open and handle catheter packages * use catheters with ch 10, 12 or 14 exclusion criteria: * pregnancy * ongoing symptomatic uti * involvement in the planning and conduct of the study (applies to both astra tech staff or staff at the study site) * previous enrolment or randomisation of treatment in the present study * participation in another clinical study during the study period * severe non-compliance to protocol as judged by the investigator and/or astra tech
analysis of intracranial artery lesions using 2-d/3d phase contrast mr

Conditions: Intracranial Arterial Aneurysm

Summary: using phase contrast mr angiography with nova® software, this study intends to identify,evaluate and map intracranial aneurysm development as well as develope a predicator for future morphological changes of aneurysms and possible risk of future rupture.

hemodynamic stress toward the wall of intracranial artery with associated genuine defects of wall remodeling capacity is one of many hypotheses of subarachnoid aneurysm development. in addition, hemodynamic stress toward an aneurysm wall may play a very significant role for the rupture of an aneurysm creating acute subarachnoid hemorrhage. we think the wall shear stress (wss) measurement toward an intracranial arterial wall and intracranial aneurysmal wall may provide valuable information for understanding of intracranial aneurysm development as well as predicting future morphological changes of aneurysm and possibly risk of future rupture. this study is significant especially in the management of unruptured subarachnoid arterial aneurysm patients and identifying patients who have higher rupture risks for active treatments such as surgical clipping or coiling to prevent unnecessary but potentially risky procedures. gadolinium mr angiography with nova® software will be used to measure the arterial wall shear stress (wss) for patients with an intracranial arterial aneurysm. the aneurysm will be identified, blood flow, velocity, volume, vascular diameter and the direction of blood measurements will be taken using nova® software at each point of interest. a wss map of target intracranial artery and/or aneurysm sac will be created and matched with morphological features providing a clue to understand the the relationships between hemodynamic parameters, especially wss and morphological changes.

Eligibility criteria:
inclusion criteria: * unruptured and ruptured adult (\>18 years) intracranial arterial aneurysm patients exclusion criteria: * less than 18 years old * chronic renal failure patients * incompetent patient who cannot give consent for routine phase contrast mr angiography and his/her surrogate decision maker is not available * any patients with a contraindication to having a standard mri examination, such as phase maker, orbital metallic foreign body, etc.

Keywords: intracranial aneurysm subarachnoid arterial aneurysm aneurysm brain aneurysm cerebral aneurysm wall shear stress(wss) hemodynamic stress subarachnoid hemorrhage(sah)
dedicated lactation support in infants with tongue - tie; a randomised control trial

Conditions: Ankyloglossia; Breast Feeding, Exclusive; Lactation Failure; Tongue-tie

Summary: the investigators are registering a randomised controlled trial to assess whether dedicated, intensified lactation support is as good as frenotomy on the incidence of breastfeeding among term infants with ankyloglossia.

the investigators plan to include a total 316 infants. the study will be carried out in level iii hospital in warsaw, poland. the primary outcome will be exclusive breastfeeding at 12 weeks of age. secondary outcomes include breastfeeding \> 50% of feedings, improved breastfeeding comfort as assessed by the mother, weight gain, head circumference and length gain, the need to use a breast pump or lactation accessories, time of breastfeeding cessation, the type of lactation, neurological and rehabilitation assistance received, the frequency of obtained lactation, neurological and rehabilitation assistance.

Eligibility criteria:
inclusion criteria: 1. full - term infants born with an apgar score of 8-10 points 2. no visual causes of lactation difficulties (malocclusion, posterior and small jaw, cervical torticollis, significant positional asymmetry) 3. parental consent exclusion criteria: 1. hypotrophy 2. low birth weight 3. perinatal complications 4. congenital craniofacial defects 5. neurological diseases 6. visible genetic syndromes 7. mother' unwilling to breastfeed 8. no consent for vaccination against hepatitis b 9. neonates born to hiv seropositive mothers
critical limb ischemia and transcutaneous oximetry

Conditions: Critical Limb Ischemia

Summary: retrospective analysis of transcutanesou oximetry (tcpo2) recording for patients referred with suspected critical limb ischemia searching for specific changes in tcpo2 patterns.

* patients had tcpo2 recording at the suspected limb and chest level at rest in the lying position. * provocative tests (leg elevation, leg lowering, oxygen inhalation) were performed to improve the sensitivity of tests. * tcpo2 results were recorded on a 1 hz bais for of line analysis after anonymization. * we recorded age , gender, weight, height, ongoing treatments , history of cardiac or respiratory disease. visual and mathematical analysis of the tcpo2 recording at the chest and limb level searching for various indices of tcpo2 variability at rest, or differences in responses between the chest and limb tcpo2 responses to provocative tests..

Eligibility criteria:
inclusion criteria: * referral for suspected critical limb ischemia exclusion criteria: * absence of recording, deny to use medical file

Keywords: transcutaneous oxygen pressure
bioequivalency study of ensartinib capsules in healthy volunteers

Conditions: Lung Cancer

Summary: the main objective of this study is to evaluate the bioequivalency of two preparations of ensartinib capsules in chinese healthy volunteers.

the main objective of this study is to evaluate the bioequivalency of two preparations of ensartinib capsules in chinese healthy volunteers under fasted state or after meal. in addition, the safety of single dose administration of ensartinib capsules in chinese healthy volunteers will also be evaluated.

Eligibility criteria:
inclusion criteria: * male body weight≥50.0kg or female body weight≥45.0kg; bmi between 19.0-26.0 kg/m2(inclusive) * generally in good health, with no history of chronic disease or sever disease * no (clinical significant) abnormal findings in clinical laboratory tests and physical examinations * no plan for pregnancy in coming 6 months, and must practice effective contraception; no plan for sperm or egg donation * written informed consent exclusion criteria: * history of food or drug allergies * clinical significant disease or disorders * received surgery in 3 months before screening, or have plan for surgery during the study * participated in other clinical trials within 3 months before screening * venipuncture intolerance * drug abusing in 6 months * donated ≥200 ml of blood within 30 days before screening * pregnant or under lactation period (female subjects) * received any prescription drug, over-the-counter drug, chinese herbal drug or vitamins in 2 weeks * received any vaccine in 4 weeks * excessively smoking, alcohol or coffin-containing beverage drinking in 3 months * other circumstances that is deemed not appropriate for the study
topical dexamethasone versus topical lidocaine spray to reduce post in shoulder arthroscopic surgeries: a comparative study

Conditions: Postoperative Sore Throat

Summary: postoperative sore throat is the most frequent side effects after anaesthesia intubation. dexamethasone and 10% lidocaine spray used prior to surgery has shown useful in managing these complications at the moment. in order to examine the prophylactic impact of local dexamethasone and lidocaine on postoperative sore throat, this study was conducted.

postoperative sore throat is the most frequent side effects after anaesthesia intubation. dexamethasone and 10% lidocaine spray used prior to surgery has shown useful in managing these complications at the moment. in order to examine the prophylactic impact of local dexamethasone and lidocaine on postoperative sore throat, this study was conducted.in this study, 100 patients were intubated to undergo general anaesthesia for shoulder arthroscopy and randomised into one of two groups. an endotracheal tube was soaked in 8mg of dexamethasone for the first group intubation, while 10% lidocaine was sprayed over the tube for the second group. following extubation, the two groups examined the severity of sore throats

Eligibility criteria:
inclusion criteria: * •patients belonging to asa physical status i, ii * patients between age18 to 50 years * patients belonging to both genders. * patients undergoing shoulder arthroscopic surgeries. * patients with fasting blood glucose \&lt;100 mg/dl or random blood sugar \&lt;140 mg/dl. exclusion criteria: * patients who are not willing to give consent for participation in the study * patients with anticipated difficult airway * patients who are allergic to steroids. * patients with asa physical status iii, iv * diabetic patients. * patients on steroids * patients requiring nasogastric tube or throat pack. * patients posted for head and neck surgeries. * patient with gerd * pregnant patients * preexisting upper respiratory tract infection.

Keywords: sore-throat postoperative dexamesthsone 10% lidocaine
functionality and accuracy of the smartrack system in real-life icu settings

Conditions: Aspiration Pneumonia

Summary: this study conducted in order to validate the functionality and accuracy of the smartrack™ system in a real-life icu setting. the smartrack™ feeding tube system is a novel system with nasogastric tube developed by art healthcare ltd, based on sensor-lined tubes that transmit real-time information to an external console. the smartrack™ feeding tube is equipped with reflux sensors which alert when gastric contents regurgitating into the esophagus. in addition, the smartrack™ feeding tube is equipped with sensors designed to provide information about the location of the tube thus assisting in reducing the incident of misplacement during first positioning. the smartrack™ feeding tube is also automatically and in real-time stops feeding if the feeding tube moves out of position during ongoing use or detect gastric content in esophagus. furthermore, smartrack™ feeding tube system can guide operator to correctly re-position the tube.


Eligibility criteria:
inclusion criteria: * males and females 18 years or older * patient has already been admitted to icu * patient requires enteral feeding * patients receiving ppi therapy * informed consent by independent physician and next of kin * icu ventilated patients exclusion criteria: * patients with anomalies or diseases of the nose, throat, or esophagus and or stomach. * patients with known sensitivities or allergies to any of the feeding tube materials * inability to place patient is semi-fowler's position. * any clinically significant abnormality upon physical examination which may, in the opinion of the investigator, pose difficulty in inserting the feeding tube (e.g. cervical spine disorder) * pregnancy * recent abdominal surgery (less than 30 days)
arterx surgical sealant, a randomized prospective multicenter trial

Conditions: Vascular Disease

Summary: this is a prospective, multi-center randomized, controlled study. the study is designed to assess the safety effectiveness of the arterx vascular sealant compared to the control group in the open surgical repair of large vessels using synthetic vascular grafts or patches.

to evaluate, during open vascular surgery, the safety and effectiveness of the arterx™ vascular sealant when applied prophylactically. application will be at synthetic vascular graft or patch to native vessel anastomosis prior to the restoration of full systemic circulation to achieve suture line sealing.

Eligibility criteria:
inclusion criteria: subject must meet all of the following criteria to be eligible for treatment in the study: 1. the subject must be equal or greater than 18 years old. 2. the subject must be scheduled for the surgical placement of a synthetic (i.e., ptfe/dacron) vascular graft or patch for large vessel repair/arterial reconstruction/hemodialysis access/arteriotomy. 3. the subject has no child bearing potential or has a negative serum or urine pregnancy test within 7 days of the index procedure. 4. the subject is willing and able to be contacted for the follow up visits at 6 weeks (± 7 days) and 3 months (± 7 days). 5. the subject or guardian must provide written informed consent using a form that is reviewed and approved by the irb. exclusion criteria: subjects will be excluded from the study if any of the following criteria are met: 1. the subject has a known hypersensitivity or contraindication to heparin, bovine or seafood products. 2. the subject has a history of bleeding diathesis or coagulopathy, or will refuse blood transfusions. 3. the subject is currently enrolled in this, or another investigational device or drug trial (ide or ind) that has not completed the required follow-up period. note: extended follow-up trials for products that were investigational but are currently commercially available are not considered investigational trials.

Keywords: arterial surgery open vascular surgery sealant
ketamine + magnesium for chronic cluster headache (ketalgia)

Conditions: Refractory Chronic Cluster Headache

Summary: chronic cluster headache (cch) is a rare primary headache disorder, defined by episodic attacks that occur for more than one year with no remission period or with remission periods lasting \< 3 months (ichd-3 criteria). in certain cases, cch patients become drug-resistant and continue to suffer almost daily attacks. ketamine appears to be effective in a variety of chronic pain conditions, such as refractory headache, and can show an enhanced analgesic effect when combined with magnesium. a single infusion of ketamine-magnesium combination has been described to reduce attacks in 17 patients with rcch. the main outcome was a comparison of the number of daily attacks two weeks prior to the infusion and one week after (days 7-8). the number of daily attacks decreased from 4.3±2.4 before treatment to 1.3±1.0 after treatment (p\<0.001). 13/17 had at least 50% response. thus, the goal of this placebo-controlled study is to try to confirm these findings.

chronic cluster headache (cch) is a rare primary headache disorder, defined by episodic attacks that occur for more than one year with no remission period or with remission periods lasting \< 3 months (ichd-3 criteria). in certain cases, cch patients become drug-resistant and continue to suffer almost daily attacks. ketamine appears to be effective in a variety of chronic pain conditions, such as refractory headache, and can show an enhanced analgesic effect when combined with magnesium. a single infusion of ketamine-magnesium combination has been described to reduce attacks in 17 patients with rcch. the main outcome was a comparison of the number of daily attacks two weeks prior to the infusion and one week after (days 7-8). the number of daily attacks decreased from 4.3±2.4 before treatment to 1.3±1.0 after treatment (p\<0.001). 13/17 had at least 50% response. thus, the goal of this placebo-controlled study is to try to confirm these findings.

Eligibility criteria:
inclusion criteria: * age \>= 18 years * chronic cluster headache diagnosis made according to ichd-3 criteria * a mean of at least 2 attacks/day during the 14 days before infusion * insufficient efficacy or intolerance or contra-indication to the use of the 3 main validated treatments (verapamil, lithium and sub-occipital steroids injections) * stable preventive treatment for at least 7 days before infusion exclusion criteria: * pregnant or lactating woman * contra-indication to ketamine use (uncontrolled high blood pressure, stoke history, severe cardiac failure) * ketamine use during the previous year * hypersensitivity to the product or their metabolites * severe renal insufficiency (creatinine clearance \< 30ml/min)

Keywords: chronic cluster headache ketamine magnesium