Kornimate/medical-research-clean huggingface dataset:
lidocaine patches prior to intravenous insertion

Conditions: Need for Intravenous Catheter

Summary: this study will determine whether application of a patch containing a topical anesthetic (numbing medicine) named lidocaine can reduce the pain of subsequent insertion of an intravenous catheter in emergency department patients.

patients will be randomly assigned to an active lidocaine patch or a patch that conatins a placebo or inactive agent. neither the patient nor the practitioner will know which patch is used since they will appear identical.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 3, * need for non-emergent intravenous catheter exclusion criteria: * unstable patients, * allergy to lidocaine or tetracaine

Keywords: intravenous catheter emergency department pain
ketamine for acute suicidal ideation in the emergency department: randomized controlled trial

Conditions: Suicide

Summary: this study will enroll patients presenting to the emergency department with acute suicidal ideation meeting inclusion and exclusion criteria. patients will be randomized to one of three arms: ketamine (intervention) or diphenhydramine (control) or placebo (control). serial measurements will be made in the ed and at follow-up intervals.


Eligibility criteria:
inclusion criteria: * patients age 18 to less than 75 who present to the sammc ed with either overt or incidental suicidal ideations with a sadpersons score 5 or greater that the treating provider feels warrant formal evaluation. exclusion criteria: * -poor vital sign stability hypoxia: o2 \ 180 heart rate: \ 120 respiratory rate: \ 30 * altered mental status or intoxication * patient is unwilling to participate or provide informed consent * any allergy to ketamine or diphenhydramine * patient is female of child-bearing age and unwilling to provide urine or blood for hcg analysis * pregnancy or breast feeding * presence of chronic oxygen-dependent pulmonary disease, liver cirrhosis, or renal disease requiring dialysis * presence of ischemic heart disease, heart failure, or a history of unstable dysrhythmias * presence of intracranial mass or vascular lesion. * presence of a history of psychosis or hallucinations (as assessed by electronic chart review) * weight greater than 115 kg or less than 45kg * history of increased intracranial pressure/hypertensive hydrocephalus * non-english speaking patients * patient is acutely psychotic * provider feels that patient currently or likely will require chemical and/or physical restraints * history of prolonged qt-interval

Keywords: suicide ketamine low-dose ketamine suicidal ideations emergency department
morphometric analysis of orbital structures in graves´ orbitopathy

Conditions: Dysthyroid Orbitopathy

Summary: the purpose of this protocol is to study orbital structures in graves´ disease using multidetector computed tomography and color doppler imaging. some changes in orbital structures detected by imaging exams could predict severity of the ocular graves´disease. thus the study could be useful in improve medical management of patients with graves´ disease.

morphometric analysis of orbital structures in graves´ orbitopathy using multidetector computed tomography scan and color doppler imaging: patients with graves´ orbitopathy are evaluated by a complete ophthalmic examination.a prospective study with multidetector ct scan and color doppler of these patients are made to develop parameters capable to predict dysthyroid optic neuropathy (don).

Eligibility criteria:
inclusion criteria: * graves´orbitopathy diagnosed based on previously reported criteria * age above 20 years * good cooperation for performing visual field test * spherical refraction within ± 5 d and cylinder correction within ± 3 d exclusion criteria: * graves´orbitopathy not diagnosed

Keywords: dysthyroid optic neuropathy multidetector computed tomography color doppler grave´s orbitopathy grave´s disease morphometric analysis
efficacy of electroacupuncture on acute abdomen emergency care

Conditions: Acupuncture

Summary: contrast to conventional western medicine, traditional chinese medicine is the most common used therapy of complementary and alternative medicine. taiwan inherits traditional chinese culture, and the people popularly accept traditional chinese medicine for general diseases. however, most patients with acute or critical illness are used to admit to emergency department for medical services, and then transfer to the department of related specialist for further treatment. during the course of staying at emergent observation room, some diseases do not meet the criteria of admission and keep for evaluation. the longer of staying at emergent observation room the more waste medical resources. the chinese medicine department of changhua christian hospital has treated patients, who consulted us at their own dispense, with subjective discomfort but remained at the emergent observation room. detailed contents of this study include the chinese and western medicine, pharmaceutical, nursing cooperation mode, monitoring clinical effect of treating of the patients diagnosed with intestinal obstruction or ileus who complain about nausea, vomiting, abdominal pain, abdominal distension or constipation.and the patients were assigned to the control and treatment group. then we give the treatment group with the electroacupuncture treatment,and the control groupe with the chinese medicine seeds and the transcutaneous nerve stimulation (no power).the patients were diagnosed with objective analysis of tongue diagnosis, pulse diagnosis, heart rate variability, and questionnaire of pain. hope that we can assess the efficacy of both two different treatment,and also assess the cost of medical care, and try to complete the syndromes statistical analysis of traditional chinese medicine for abdominal pain, building the relevance of chinese medicine physical assessment teaching and clinical efficacy. the most important of this clinical teaching is that, this is a good opportunity for chinese medicine and western medicine to cooperate with each other at the emergency department to confirm the efficacy of traditional chinese medicine, not only in the field of chronic or geriatric diseases, but also in the field of emergency with the evidence base. this factually achieves communication and integration of chinese and western medicine, and benefits the public.


Eligibility criteria:
inclusion criteria: 1. patients 20-90 years old,who accepted to enter this trial 2. the patients diagnosed with intestinal obstruction or ileus who complain about nausea, vomiting, abdominal pain, abdominal distension or constipation. 3. icd-10 is r101-r1012 exclusion criteria: does not meet the above conditions

Keywords: traditional chinese medicine electroacupuncture abdominal pain
efficacy of magnesium and alpha lipoic acid supplementation in reducing premature uterine contractions

Conditions: Pregnancy

Summary: to evaluate whether a combined supplementation of magnesium and lipoic acid is able to significantly reduce the incidence of uterine contractions and related episodes of hospitalization in pregnant women.

primary prevention of preterm labor is based on the early identification of risk factors and on appropriate treatments. although several drugs are currently used, the identification of effective and safe agents able to improve both maternal and fetal health is still warranted. in this study the efficacy a formulation based on magnesium and alpha-lipoic acid has been compared with placebo to evaluate the incidence of reduction of preterm delivery. three hundred pregnant women at 14-34 weeks of gestation were enrolled and randomly divided to receive a daily single tablet containing magnesium and alpha-lipoic acid supplement or placebo until delivery.

Eligibility criteria:
inclusion criteria: * 14-34 weeks of gestation exclusion criteria: * preexisting diabetes mellitus * systolic blood pressure \>140mm hg * cancer * lupus * hepatitis * hiv/aids * diagnosed alcohol or chemical dependency
a study to evaluate the safety, tolerability, and pharmacokinetics of ub-921 in healthy volunteers

Conditions: Breast Neoplasm

Summary: the purpose of the study is to evaluate the safety, tolerability, and pharmacokinetics of escalating single-dose of ub-921 in healthy male volunteers.

this is an open-label, two-part, dose-escalation and comparative pharmacokinetics study of ub-921 in healthy male volunteers. there will be two parts: dose escalation study (main study) and comparative pharmacokinetics study (sub-study).

Eligibility criteria:
inclusion criteria: * total body weight ≧50 kg (110 lbs) * no clinically relevant abnormalities * to agree on using birth control barrier (eg. male condom) during the entire study period. * signing the written informed consent form exclusion criteria: * previous exposure to chimeric, humanized or human monoclonal antibody, whether licensed or investigational * a history of drug abuse or heavy drinking. * blood donation over 250 ml within 90 days prior to the screening * not in the condition to participate in this study considered by investigator(s)

Keywords: ub-921 anti-her2 monoclonal antibody breast neoplasm breast cancer herceptin trastuzumab her2
neural mechanisms of meditation for opioid-treated chronic low back pain

Conditions: Low Back Pain; Opioid Use

Summary: the purpose of this research study is to see how a mindfulness meditation-based intervention affects pain. specifically, we are interested in understanding the pain-relieving brain mechanisms of mindfulness meditation-based therapy for patients with opioid-treated chronic low back pain.


Eligibility criteria:
inclusion criteria: 1) men/women 18-65 years of age; 2) current chronic low back pain classified according to the nih pain consortium task force research standards for chronic low back pain (pain on at least half the days in the past 6 months); usual back pain ≥3 on 0-10 scale with opioid medication; and 4) current use of prescription opioids for ≥3 months. exclusion criteria: 1) prior experience with mbsr, mbct, more, or extensive involvement in any standardized meditation training, 2) current cancer diagnosis, 3) suicide intent or attempt in the past 30 days, 4) psychosis or moderate/severe non-opioid substance use disorder in past 6 months; 5) persons with any electronic objects or certain metal objects in their head or body that are incompatible with mri; 6) those who have had an abnormal brain mri in the past; 7) those unable to lie still on their back for 1 to 1.5 hours; and 8) pregnancy.
phase ii study of rt-pepc in relapsed mantle cell lymphoma

Conditions: Non-Hodgkin's Lymphoma

Summary: primary objective: evaluate the clinical activity of the rt-pepc combination regimen (rituximab, thalidomide, and prednisone, etoposide, procarbazine, cyclophosphamide) in patients with relapsed mantle cell lymphoma. specifically, response rate (rr) and time to disease progression (ttp) will be assessed. secondary objectives: 1. assess the toxicity profiles of rt-pepc treatment in patients with relapsed mantle cell lymphoma. 2. prospectively characterize the angiogenic profile of patients with mantle cell lymphoma during treatment with rt-pepc. the dynamics of the angiogenic profile will be correlated with clinical response to rt-pepc therapy. 3. assess the quality of life of patients receiving rt-pepc treatment


Eligibility criteria:
inclusion criteria: * histologically confirmed diagnosis of mantle cell non-hodgkin's lymphoma with characteristic immunophenotypic profiles: cd5(+),cd23(-), cd19(+) or cd20(+), cyclin d1(+), and cd10(-) * patient has persistent / recurrent disease after standard chemotherapy * patient has not received either standard or investigational drugs within the last 3 weeks * available frozen tumor tissue obtained since completion of last prior therapy (rebiopsy if needed) * patient has measurable disease as defined by a tumor mass \> 1.5 cm in one dimension * age \> 18 years * absolute granulocyte count \> 1000 cells/mm3 * platelet count \> 50,000 cells/mm3 * creatinine \< 2.0 x uln * total bilirubin \< 2.0 x uln * patient has kps \> 50% * patient agrees to use birth control if of reproductive potential exclusion criteria: * known central nervous system (cns) involvement by lymphoma * known hiv disease * known peripheral neuropathy \> grade 2 * patient is pregnant or nursing * patient has had major surgery within the last 3 weeks * patient is receiving other investigational drugs

Keywords: relapsed mantle cell lymphoma
study to evaluate the pharmacokinetics and safety of singulair and xyzal in free combination and fixed-dose combination

Conditions: Rhinitis

Summary: the purpose of this study is to evaluate the pharmacokinetics and safety of singulair (10 mg) and xyzal (5 mg) in free combination and fixed-dose combination as hcp1102


Eligibility criteria:
inclusion criteria: * healthy male * age between 20 and 55 * signed informed consent exclusion criteria: * has a history of hypersensitivity to ip ingredients * hypotension or hypertension * has a history of acute infection within 14 days of screening

Keywords: rhinitis
a study of the safety and efficacy of combination therapy with morphine, phenylephrine and sorbitol in human subjects

Conditions: Acute Pain

Summary: efficacy and safety of the combined oral adjuvants phenylephrine and sorbitol on oral low dose morphine analgesia.

the primary objective of this study is to determine the efficacy of the combined oral adjuvants phenylephrine and sorbitol on oral low dose morphine analgesia.

Eligibility criteria:
inclusion criteria: * ability to provide written informed consent * healthy male or female between 18 and 40 years of age, inclusive. * women have to test negative for pregnancy. * body weight within 15% of ideal body weight based on metropolitan life assurance tables. * no concomitant medications (prescription, otc, vitamins, dietary supplements) within 7 days prior to administration of study medication and during the study period. * ability to adhere to the visit schedule and protocol requirements and be available to complete the study * ability to participate successfully in training sessions that will be arranged for the volunteers prior to the study day, during which they will acquire consistency in the tests to be performed. * ability to satisfy a medical examiner about fitness to participate in the study exclusion criteria: * prior use of chronic opioids * mental illness prior or present * evidence of significant concomitant disease, including renal, hepatic, cardiovascular, pulmonary, endocrinological, hematopoietic, or gastrointestinal disease, a neoplasm or any other clinically significant medical disorder, which in the investigator's judgment contraindicate administration of the study medications * known allergy to any of the drugs used in this study * history of drug or alcohol abuse * significant abnormalities in screening physical exam * administration of drugs that may potentially inhibit or induce liver cytochrome p450 activity within 3 weeks prior to day 0 * any acute medical situation (e.g. acute infection) within 48 hours of day 0, which is considered of significance by the principal investigator * unusual diet * administration of experimental medications within the previous 12 weeks. * inability to communicate well with the investigator (i.e., language problem, poor mental development or impaired cerebral function) * subjects who, in the judgment of the investigators, are likely to be non-compliant or uncooperative or unwilling to sign a consent form
comparison of active and passive static stretching in delayed onset of muscle soreness of recreational body builders

Conditions: Sports Physical Therapy

Summary: to find out the better treatment options from active and passive static stretching in delayed onset of muscle soreness in recreational body players.

after registering participant's randomization will be done through sealed envelope method and will be allocated in both groups equally. group 1 will receive passive static stretching while group 2 will receive active static stretching. all subjects will be assessed before the intervention through likert muscle soreness scale, numeric rating pain scale and range of motion for shoulder, elbow, and wrist by a goniometer. after that all subjects will perform eccentric exhaust weight exercises in the gym of all mentioned joints, three sets at each joint. before giving the intervention they will assess of all mentioned parameters. group 1 groups will perform passive static stretching and group 2 will perform active static stretching. at the end of the intervention participants will be assessed again using the same parameters. statistical analysis will be carried out to compare the outcomes measures of both groups.

Eligibility criteria:
inclusion criteria: * recreational body builders are included exclusion criteria: * individuals with disc herniation and * acute muscle soreness are excluded

Keywords: active stretching passivestretching recreational body players
healing experiences of adversity among latinos (healthy4you)

Conditions: Stress; Childhood Obesity

Summary: healing experiences of adversity among latinos (healthy4you) is a project funded by the california initiative for the advancement of precision medicine ("advancing a precision population health approach to aces to reduce health disparities"). the long-term goal of this project is to develop community-centered, culturally appropriate, precision interventions that can be delivered within federally qualified healthcare centers (fqhcs) for latino families, to reduce adverse child events (aces) risks and treat childhood obesity. ucsd in conjunction with family health centers of san diego (fhcsd) will conduct a 2x2 factorial trial with four groups meant to determine what combination of intervention components influence family protective factors (a key marker for reduced risk of the deleterious effects of systemic and family/individual stressors that are a critical part of aces) and childhood obesity.


Eligibility criteria:
inclusion criteria: * child * currently a patient at family health centers of san diego * age 5-11 years old * bmi ≥ 85th percentile to 99.9th percentile * social determination or risk for ace determined as being a patient receiving care at an fqhc (confirmed via provider) * parent * parent or guardian (including non-biological parent or relative) willing to participate * self-identification as hispanic or latino * 18 years or older * english or spanish speaking * willingness to commit to 6 months of the program exclusion criteria: * serious developmental disability (parent or child) * serious mental health illness (parent or child)

Keywords: aces obesity adverse childhood experiences 2x2 factorial study behavioral intervention health education healthy together parenting protective factors precision medicine federally qualified health centers latino hispanic pediatric whole child wellness
repetitive transcranial magnetic stimulation(rtms) regulating slow-wave to delay the progression of parkinson's disease

Conditions: Parkinson's Disease

Summary: at present, no drug therapy has been proven to delay the progression of parkinson's disease (pd). rtms, as a non-invasive neuromodulation method, can regulate slow-wave sleep (sws). sws is recognized closely related to neurodegeneration. however, there has been no clinical studies on if rtms could delay the progression of pd by regulating sws. the main purpose of this study is to explore the changes of sws in non-rapid eye movement (nrem) sleep period in pd patients by using rtms, and the relationship with potential improvements of sws and motor symptom delay. the study aims to find a potential new treatment strategy to delay the neurodegenerative process in pd patients by modulating sws by rtms.


Eligibility criteria:
inclusion criteria: 1. meet the clinically definite or clinically probable pd according to the mds 2015 version. 2. chinese han population (three generations), age greater than or equal to 50 years old, less than or equal to 80 years old, male or female. 3. hoehn-yahr stages 1-4. 4. the dose of levodopa drug therapy was stable three weeks before enrollment and during the follow-up period. 5. right-handed. 6. the patient signed a written informed consent. exclusion criteria: 1. any form of parkinsonism other than primary pd. 2. those who have received neurosurgical intervention or stereotaxic brain surgery for pd, or have previously received tms treatment. 3. cognitive dysfunction (mmse ≤ 24 points) or those who cannot cooperate with the scale score. 4. persons with mental disabilities. 5. pregnant women. 6. there are contraindications for rtms treatment. 7. there are contraindications for mri examination. 8. baseline psg suggests other sleep disorders such as moderate to severe osas; bmi\>=30. 9. patients who are addicted to alcohol, taking ssris, tcas, sedative hypnotics, histamine antagonists and other drugs and food that may affect nrem and rem sleep structure. 10. those who are unwilling to participate in the study or unable to sign the informed consent form; and other circumstances that the researcher considers inappropriate to participate in the study. -

Keywords: parkinson's disease slow-wave sleep rtms motor symptom progression
efficacy of core strengthening and intensive dynamic back exercises in patient with low back pain

Conditions: Low Back Pain

Summary: the study aimed to investigate the efficacy of core strengthening and intensive dynamic back exercises on pain, muscle strength, endurance, and functional disability in patients with chronic non-specific low back pain.

the study will be based on a three-arm parallel group randomized control design. forty-five participants with chronic non-specific low back pain will be recruited from the physiotherapy department, at integral university, india. study objectives and procedure will be properly explained and written informed consent will be obtained at the beginning of the study. all the participants will be randomly divided into three groups a, b, and c. experimental group a will be receiving the hot pack, active stretching, isometric exercise intervention, and core strengthening exercises while group b will receive the hot pack, active stretching, isometric exercise intervention, and intensive dynamic back exercises, control group c will receive the hot pack, active stretching, isometric exercise intervention.

Eligibility criteria:
inclusion criteria: * age 20-50 years * chronic low back pain (\>3 months), exclusion criteria: * participants with low back pain related to cancer, * infection, * inflammatory arthropathy, * high-velocity trauma, * fracture * low back pain associated with severe or progressive neurological deficits trauma * pregnancy.