Kornimate/medical-research-clean huggingface dataset:
effects of masticatory muscles training exercises on the masticatory performance and rehabilitation of stroke patients

Conditions: Mastication

Summary: stroke is one of the top causes of death and morbidity of adults, especially the older population in the economically developed countries. people who survives from stroke attack usually suffer from a wide range of impairments and often have poor chewing ability even when they are physically well enough to be discharged from hospital. aim of this proposed study is to investigate the effects of providing masticatory muscles training exercises on the masticatory performance, nutrition intake and general health conditions of stroke rehabilitation patients. around 100 stroke patients undergoing rehabilitation in the rehabilitation centre in tung wah eastern hospital, hong kong, will be recruited and allocated randomly into one of two study groups: group 1 will be provided with an oral device for chewing muscles exercises and training exercises on chewing (the intervention group); and group 2 will just follow the current stroke rehabilitation programme which does not have any training in chewing (a negative control group). a video on the chewing muscles exercises will be produced and placed online for the participants in group 1 to view on demand. data from the participants in both groups will be collected at four time points: at baseline before provision of the interventions, and at around 1, 3 and 6 months after the intervention. each participant will be interviewed by a trained interviewer and undergo a clinical examination. the information collected will include the participant's oral health status such as numbers of decayed teeth and occluding tooth pairs, and their masticatory performance measured both objectively by chewing on a colour-changeable gum and subjectively by a chewing function questionnaire. their type of stroke (ischemic or hemorrhagic) and general health conditions such as physical function status and nutrition intake will be recorded. the masticatory performance and general health conditions of the two groups of study participants at baseline and follow-up evaluations will be compared to assess if the masticatory muscles training exercises can improve the rehabilitation outcomes. it is anticipated that this proposed randomized trial will provide high-level clinical evidence to support the introduction of masticatory muscles training exercises into the rehabilitation programme of stroke patients and to inform how the exercises will benefit the patients, such as improving their chewing ability and general health conditions.


Eligibility criteria:
inclusion criteria: * aged 30 years or above, first-time stroke patient within 20 days post-stroke and medical status being stable exclusion criteria: * unable to follow basic instructions, unable to communicate clearly, being bed-ridden, dysphagic (on nasogastric tube) and not having any natural teeth in either of the jaws
saving and empowering young lives in europe (israel)

Conditions: Depression; Suicidality

Summary: seyle is a health promoting program for adolescents in european schools. its main objectives are to lead adolescents to better health through decreased risk-taking and suicidal behaviors, to evaluate outcomes of different preventive programs and to recommend effective culturally adjusted models for promoting health of adolescents in different european countries. because of the significance of the seyle program and the importance of suicide research, israel is honored to take part in this program and be a collaborator in it's implementation and research.

in this health promotion program, a pilot intervention study will be implemented to assess the effects of three different health promoting / suicide prevention programs in 11,000 students across 11 european countries (sweden, austria, estonia, france, germany, hungary, ireland, israel, italy, romania, slovenia and spain): 1. a general health promotion program targeting students' awareness on healthy/unhealthy behaviours and students' self-efficacy in diminishing unhealthy behaviours; 2. profscreen - screening by professionals of at-risk students through a questionnaire. for adolescents identified as high risk (screen positives) the program includes referral to mental health treatment and ensuring compliance. 3. qpr (question, persuade \& refer) - a gatekeepers' program, training all adult staff at schools (teachers, counselors, nurses etc.) and parents on how to recognize \& refer a student with risk-taking behaviours or suffering from mental illness to mental-health help resources. each of these prevention programs uses a different active component in order to be successful. the first prevention program empowers the students by increasing their self-efficacy. the second prevention program (profscreen) empowers mental health professional in identifying subjects at risk. the third program (qpr) empowers teachers and parents in at-risk case finding and referring to mental health facilities. the registration of the complete rct is available on the german clinical trials registry (drks00000214).

Eligibility criteria:
inclusion criteria: * adolescents between 13-17 exclusion criteria: * none

Keywords: data on student's healthy and at-risk lifestyles and their relation with health measured by well-being, depression and suicidality
research on body voice ai recognition system for children's health management

Conditions: Congenital Heart Disease; Bronchopneumonia; Abdominal Disease

Summary: the purpose of this research is to develop a body voice artificial intelligence (ai) recognition device, also referred to as an ai-assisted body sound identification device, by utilizing a deep learning-based novel ai algorithm in conjunction with a big body voice model. it could identify normal and abnormal heart, breath, and bowel sounds, and to provide early screening and auxiliary diagnosis of congenital heart disease (chd), respiratory infections, diarrhea and other common multi-occurring diseases.

the study employed a multicenter cross-sectional design. the real-world data collected for this study included normal and definitively diagnosed heart sounds in children with congenital heart disease, normal and definitively diagnosed respiratory tract infections in children with breath sounds, specific cough sounds, and normal and definitively diagnosed children's bowel sounds with diarrhea. the specialist team will carry out data governance, annotation, and feature sound extraction on the gathered normal and aberrant sounds, in order to generate a superior multimodal training dataset. large model artificial intelligence algorithms (deep learning, machine learning, etc.) are used to model and train the algorithm model of the body voice ai recognition device, so that it can distinguish between normal and abnormal sound signals by ai. the results of body sound ai identification will be compared with diagnostic reports from echocardiograms, chest x-rays, and belly x-rays in terms of auc (area under curve) score, sensitivity, specificity, and accuracy to evaluate the impact of ai recognition devices on illness screening and supplementary diagnosis. external validation will be conducted using homogeneous data from other sites. this project aims to develop a new generation of intelligent sound auscultation instruments that could be used for early screening and auxiliary diagnosis of congenital heart disease , respiratory infections, diarrhea and other common multi-occurring diseases by utilizing large model artificial intelligence technologies.

Eligibility criteria:
inclusion criteria: 1. age 0\~18 years old, gender is not limited 2. children who have been diagnosed with congenital heart disease by cardiac ultrasound or who do not have congenital heart disease 3. children diagnosed with bronchopneumonia or without bronchopneumonia 4. children who are clinically diagnosed with intestinal diseases or who do not suffer from intestinal diseases 5. informed consent exclusion criteria: 1. ≥ 18 years old 2. children who are unable to undergo cardiac ultrasound, chest imaging or other related examinations 3. subjects who are unable to obtain informed consent, or who are unwilling to cooperate with the provision of diagnosis and treatment related data for further analysis and research as required by the study.
the effect of glutamine on systemic inflammation during human experimental endotoxemia

Conditions: Sepsis; Systemic Inflammation

Summary: glutamine levels decrease during severe sepsis; this may be associated with increased mortality. the investigators tested the effects of glutamine supplementation on systemic inflammation in a human sepsis model. the investigators found that glutamine levels drops significantly during experimentally induced systemic inflammation. however, glutamine did not affect the degree of inflammation.

glutamine levels have been shown to decrease substantially with severe sepsis and this has been connected with increased mortality. therefore, in the present study, we infused either saline or alanine-glutamine during an endotoxin challenge and measured parameters related to an immune response, i.e. plasma cytokines and heat shock protein (hsp)-70. materials and methods this was a double blind, randomised, placebo-controlled crossover trial in eight healthy young men. the study was performed in random order on two separate days, with a four-week washout period between days. subjects received an infusion of alanine-glutamine ( dipeptiven) at a rate of 0.025 g / (kg bw \* h) for 10 hrs or saline. after two hours of infusion subjects received an intravenous bolus of e. coli endotoxin (0.3 ng/kg). blood samples were collected hourly for the following eight hours. hsp-70 protein content in isolated blood mononuclear cells (bmncs) was measured by western blotting. results and discussion plasma glutamine was significantly increased during infusion with alanine-glutamine infusion. en-dotoxin caused a reduction in plasma-glutamine during saline infusion as well as during alanine-glutamine infusion. a significant effect of endotoxin was found on leukocyte subpopulations, tumor necrosis factor-a, interleukin-6, the expression of hsp-70 in bmncs, temperature, and heart rate. however, no differences were detected between treatments with regard to the effect of endotoxin on any of these parameters. conclusion endotoxemia reduces plasma glutamine independently of parenteral infusion of alanine-glutamine. glutamine does not alter the response of leukocytes, leukocyte subpopulations, il-6, or tnf-α, or the expression of hsp-70 in bmncs to endotoxemia.

Eligibility criteria:
inclusion criteria: * healthy young males exclusion criteria: * any kind of acute or chronic diseases

Keywords: glutamine inflammation hsp70 sepsis
study to assess if quinvaxem can be interchanged with other pentavalent vaccines during standard childhood vaccination

Conditions: Diphtheria; Pertussis; Tetanus; Hepatitis B; Haemophilus Infections

Summary: this is a study to show that vaccination with 1 dose of tritanrix hb+hib followed by quinvaxem vaccine as the 2nd and 3rd dose is not inferior to vaccination with quinvaxem for all 3 doses, with respect to protection against all antibodies (anti-hepatitis b surface antibodies, anti-polyribosyl ribitol phosphate (prp), anti-diphtheria, anti-tetanus and anti-bordetella pertussis) 1 month after completion of the 6-10-14 week vaccination course.


Eligibility criteria:
inclusion criteria: * a male or female between, and including, 42 and 64 days of age at the time of the first vaccination * written informed consent obtained from parents/legal guardian of the subject * free of obvious health problems as established by medical history and/or clinical examination before entering the study * hepatitis b vaccination at birth (within 48 hours) available for all scheduled study visits exclusion criteria: * use of any investigational drug or any investigational vaccine within 30 days preceding the first dose of study vaccine, or planned use during the study period and safety follow-up * planned administration of a vaccine not foreseen by the study protocol * known or suspected impairment of immune function, known human immunodeficiency virus (hiv)-positivity, receiving immunosuppressive therapy, or having received systemic immunosuppressive therapy within 1 month prior to study entry (note: inhaled and topical steroids are allowed) * administration of parenteral immunoglobulin preparation and/or blood products since birth * previous vaccination against haemophilus influenzae type b (hib) and/or diphtheria, tetanus, pertussis (dtp) * history of anaphylaxis, or any serious vaccine reaction, or allergy to any vaccine component or to products containing mercury compounds, such as sodium ethylmercuro-thiosalicylate * significant acute infection * any condition which, in the opinion of the investigator, might interfere with the evaluation of the study objectives * participation in another clinical study

Keywords: vaccination immunisation virus diphtheria pertussis tetanus hepatitis b haemophilus influenzae immunity
efficacy of thymosin alpha1 for severe sepsis

Conditions: Severe Sepsis

Summary: the purpose of this study is to evaluate the efficacy of thymosin alpha 1 for treating severe sepsis.

severe sepsis is a disease of infectious origin with a high risk of death. over the past decade, thymosin alpha1 have already provided clinicians with additional weapon in the fight against infectious diseases, but it is unknown whether thymosin alpha1 is effective in treating severe sepsis.

Eligibility criteria:
inclusion criteria: * severe sepsis according to accp/ccm criteria * patient or legally authorized representative able to provide informed consent exclusion criteria: * subject is less than 18 years or more than 85 years of age * if female, the subject is pregnant or nursing * subject is receiving immunosuppressive therapy such as cyclosporine, azothioprine,or cancer-related chemotherapy * patient not expected to survive 28 days because of uncorrectable medical condition, such as poorly controlled neoplasm or other end-stage disease * history of bone marrow, lung, liver, pancreas, or small-bowel transplantation * acute pancreatitis with no established source of infection

Keywords: sepsis immunotherapy thymosin
study to evaluate ep547 in subjects with cholestatic pruritus due to primary biliary cholangitis or primary sclerosing cholangitis

Conditions: Pruritus

Summary: this phase 2 trial will evaluate the effects of ep547 in subjects with cholestatic pruritus due to primary biliary cholangitis (pbc) or primary sclerosing cholangitis (psc)


Eligibility criteria:
inclusion criteria: * age 18 to 80 years * documented primary biliary cholangitis (pbc) or primary sclerosing cholangitis (psc) * presence of consistent moderate to severe pruritus * use of anti-pruritic and anti-cholestatic (including udca and obeticholic acid) medication allowed if meeting additional criteria * individuals with concomitant inflammatory bowel disease must meet additional relevant criteria exclusion criteria: * pruritus associated with an etiology other than pbc or psc * prior or planned liver transplantation * evidence of compensated or decompensated cirrhosis * alternative causes of liver disease * presence of documented secondary sclerosing cholangitis * current evidence of clinically significant high-grade strictures or presence of biliary stent * history of significant small bowel resection or short bowel syndrome * has exclusionary laboratory or biochemical results at screening

Keywords: pruritus itch primary biliary cholangitis primary sclerosing cholangitis pacific ep547
old blood and postoperative complications

Conditions: Orthopedics; Postoperative Complications; Red Blood Cells

Summary: the investigators sought to examine the effects of 'old' red blood cells on mortality and morbidity of patients who undergoing revision hip replacement arthroplasty. the investigators hypothesis is that patients have an increased risk of mortality and infection after 'old' red blood cells transfusions compared with those who received 'new' transfusions.


Eligibility criteria:
inclusion criteria: * patients who underwent revision total hip replacement exclusion criteria: * patients who were not given red blood cells * patients who were given two units of which one unit was old and one was new
progression of health related quality of life of patients waiting for total knee arthroplasty

Conditions: Knee Arthroplasty; Knee Arthroplasty, Total; Knee Replacement, Total; Replacement, Total Knee; Total Knee Replacement; Health-Related Quality Of Life; Life Quality; Osteoarthritis Of Knee

Summary: to evaluate the progression on patients suffering from end stage oa whilst being on the waiting list for tkr

total knee arthroplasty (tka) remains the surgical gold standard treatment for patients suffering from end stage osteoarthritis (oa) of the knee. however, due to the high demand and scarce medical resources, the waiting time for surgery is astoundingly lengthy. controversies are shown on numerous studies on whether physical functionality and mental status decline or remain stable over the waiting period. this study aims to evaluate the progression on patients suffering from end stage oa whilst being on the waiting list for tkr.

Eligibility criteria:
inclusion criteria: 1. diagnosed with symptomatic osteoarthritis 2. enlisted on the tka surgical waiting list 3. ethnic chinese 4. fluent in cantonese exclusion criteria: 1. evidence of cognitive dysfunction like dementia 2. surgery scheduled within 30 days 3. severe co-morbidity preluding participation

Keywords: hrqol quality of life end stage osteoarthritis total knee arthroplasty womac sf 36 total knee replacement
brca1 and brca2 mutation in romanian population: a study of genotype - phenotype correlation at diagnosis with prospective disease outcome and survival

Conditions: To Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian Cancer

Summary: primary objective to determine brca1 and brca2 variants in 250 romanian women with breast/ovarian cancer selected for likeliness to harbor germline mutations in these genes by specific criteria for high-risk status including age at disease onset. secondary objective considering the fact that brca testing is not a routine procedure in romania and mutation prevalence varies in different populations, we intend to look for the founder mutation in our population, running full brca genes sequencing to a representative population sample. this would allow a more targeted approach to real-life practice and would ensure personalized solutions for every patient in need.


Eligibility criteria:
inclusion criteria: categories of patients to be recruited for complete sequencing of all brca1 and brca2 exons are subjects who have been diagnosed with breast or ovarion cancer and who are: 1)40 years of age or younger 2)triple negative breast cancer diagnosed before 50 years of age 3)male with breast cancer 4)bilateral breast cancer, first tumor diagnosed before 50 years of age 5)2) + 50 years of age or younger with at least one (first degree) relative diagnosed with breast cancer at 50 years of age or younger or a first degree relative with ovarian cancer 6)of any age with 2 or more relatives with breast cancer 7)of any age with 2 or more relatives with ovarian cancer 8)of any age with a personal history of ovarian cancer, tuba or peritoneal carcinoma 9)two patients in same branch of the family, prostate ca \< 60 yr and 1st degree relative with bc \< 50 yr 10)two or more 1st and 2nd degree relatives of a patient with breast cancer, at least one of them \<50 yr 11)of any age with a family history of male breast cancer or are at increased risk of having a brca mutation based on brcapro or tyrer-cuzick models exclusion criteria: -
positive expiratory pressure (pep) and continuous high-frequency oscillation (chfo) on lung recruitment using electrical impedance tomography (eit) - the pep-recruit study

Conditions: Recruitment; Respiratory Failure

Summary: this single-center observational study aims to assess the effects of continuous high-frequency oscillation (chfo) and continuous positive expiratory pressure (cpep) therapy on lung recruitment using electrical impedance tomography (eit) in spontaneously breathing patients admitted to the intensive care unit.


Eligibility criteria:
inclusion criteria: * patients who require pulmonary expansion and airway clearing as per clinical indication * patients who provide valid informed consent according to local regulations * pao2/fio2 \< 200 mmhg at inclusion * patient on the airway care score (acs) \< 7 exclusion criteria: * refuse to participate * age \< 18 years * hemodynamic instability, defined as systolic arterial pressure \< 90 mmhg or mean pressure \< 60 mmhg * contraindication to using an eit (i.e., pacemaker or defibrillator) * inability to properly position the eit device for anatomical reasons
robotic versus hybrid assisted ventral hernia repair

Conditions: Pain; Quality of Life; Recurrence

Summary: laparoscopic ventral hernia repair (lvhr) may be associated with chronic pain, seroma formation, bulging and failure to restore abdominal wall function. these outcomes are risk factors for hernia recurrence and poor quality of life (qol). our study evaluates whether robotic-assisted ventral hernia repair (rvhr) diminish these complications compared to lvhr with primary closure of the defect (hybrid).

thirty patients undergoing incisional ventral hernia operation with fascial defect size from 3 to 6 cm will be recruited. fifteen patients undergo rvhr and fifteen undergo hybrid operation.the main outcome measure is postoperative pain, evaluated with visual analogue scale (vas: 0-10) preoperatively, at 1-week, at 1-month and at 1-year. hernia recurrence will be evaluated with ultrasound examination at 1-year and qol using the generic sf-36 short form questionnaire preoperatively, at 1-month and at 1-year.

Eligibility criteria:
inclusion criteria: * ventral hernia size 3-6 cm exclusion criteria: * previous ventral hernia

Keywords: ventral hernia laparoscopy robot-assisted pain
intraoperative periarticular injection in arthroscopic anterior cruciate ligament reconstruction surgery

Conditions: Anterior Cruciate Ligament (ACL) Tear; Arthroscopic Anterior Cruciate Ligament Reconstruction

Summary: in this prospective, assessor-blinded, single-surgeon clinical trial, the goal was to validate the efficacy of pai in aaclr surgery with a reduced opioid dose, while achieving similar pain relief with few adverse events. 300 patients who had undergone aaclr were randomly allocated to receive either a pai or npai group. the primary outcome parameters were visual analogue scale (vas) scores and cumulative morphine dose, through time. secondary outcome parameters included drug-related adverse events.


Eligibility criteria:
inclusion criteria: * 1) patients 18 years or older who had undergone a-aclr with or without meniscus procedure for anterolateral instability of the knee; 2) agree to participate in this study and to be randomly allocated to either or peri-articular injection protocol and have signed an informed consent. exclusion criteria: * 1) patients with other concomitant injuries such as other ligamentous injury or fracture; 2) allergy to any of the medication used in either protocol; 3) patient with history of the chronic pain 4) preoperative chronic opioid-dependent patients (exceeding 50 mg oral morphine equivalence per day at time of recruitment); 5) refuse to participate in this study.

Keywords: periarticular injection morphine consumption pain control