Kornimate/medical-research-clean huggingface dataset:
comparison of adenoma detection rate among water, carbon dioxide and air methods of minimal sedation colonoscopy

Conditions: Screening Colonoscopy

Summary: the purpose of this study is to determine which of the methods of colonoscopy viz. water insufflation or air insufflation or carbon dioxide insufflation is better in detecting the adenomas in colon and also which of these methods is best tolerated by patients. hypothesis: the investigators hypothesize that in patients undergoing first time screening colonoscopy a higher adenoma detection rate will be found in the proximal colon in the group randomized to the water method compared to those randomized to the air or co2 insufflation methods

significance: adr is an independent predictor of risk of post screening colonoscopy colon cancer. a simple method solely controlled by the colonoscopist that enhances proximal adr holds the promise of rectifying some of the unresolved shortcomings of screening colonoscopy in failing to reduce the occurrence of post screening incident cancers in the proximal colon and the associated cancer mortality. hypotheses \& specific aims: primary hypothesis: in patients undergoing first time screening a higher adr will be found in the proximal colon in those randomized to the water method compared to those randomized to the air method or co2 method. secondary hypotheses: the examination method but not co-variables, procedure-related or patient-centered outcomes, is an independent predictor of proximal colon adr. specific aims: this is a prospective, randomized, single-blinded controlled study to compare the study (water) and control 1 (air) method and control 2 (co2 method) to aid insertion of the colonoscope. the proximal colon adr, total adr, co-variables, procedure-related and patient-centered outcomes and adverse event during and within 30 days of colonoscopy will be recorded and compared between the study and control methods.

Eligibility criteria:
inclusion criteria: * asymptomatic patients with average risk for colorectal cancer, who are scheduled for first-time screening colonoscopy, will be enrolled. exclusion criteria: * decline to be randomized * unable to give consent * non-screening (surveillance or diagnostic) colonoscopy * current participation in other colonoscopy studies * a medical condition that could increase the risk associated with colonoscopy * pregnancy * those with a known family history of polyposis syndromes or a family history of colon cancer

Keywords: screening colonoscopy water method carbon dioxide method air method water versus carbon dioxide versus air insufflation colonoscopy adenoma detection rate pain scores in colonoscopy
immunological characterization of bronchoalveolar cells in normals

Conditions: Lung Disease

Summary: to obtain the monocytes (white blood cells) from normal volunteers for the purpose of studying how proteins, fats, carbohydrates, as well as rna and dna for gene expression, relate to immunity. this information will be compared to other studies in patients with lung diseases such as emphysema, sarcoidosis, and interstitial pulmonary fibrosis.

to determine the functional capabilities of cells obtained from bronchoalveolar lavage fluid and peripheral blood monocytes from normal individuals. the ongoing objective varies from investigation to investigation but in general the investigational goals are to better understand the immune function of monocytes purified from normal volunteers. in some instances the emphasis will be upon comparing the specific immune function (e.g. ability to sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar macrophages. this comparison is not the only goal of the study, however. in many cases the immune function of the monocyte will be sufficient in and of itself as an investigational goal. in other cases the same is true of alveolar macrophage function.

Eligibility criteria:
inclusion criteria: * healthy exclusion criteria: * unable to consent

Keywords: emphysema sarcoidosis interstitial pulmonary fibrosis
peritonsillar bupivacaine infiltration after tonsillectomy in children

Conditions: Post Operative Delirium; Post Operative Pain

Summary: to evaluate the effect of peritonsillar bupivacaine infiltration on the development of postoperative delirium in pediatric patients undergoing tonsillectomy or adenotonsillectomy.

postoperative emergence delirium (ed) is an important clinical condition characterized by crying, irritability and severe restlessness in subjects recovering from anesthesia. ed is more common in children than in adults. among the types of surgery, the ed is common in ent surgery in which the prevalence was reported between 13%-26%. the adenotonsillectomy, which is a common ent procedure carry a high risk for development of ed. the ed can cause the child recovering from anesthesia to harm himself/herself and the surgical site and may cause parents to question the quality of anesthesia. it is associated with postoperative increased morbidity. several anesthetic strategies exists (intranasal premedication, deep versus awake removal of the laryngeal mask, different intravenous anesthetic combinations) in the literature in order to prevent delirium. local anesthetic application as xylocaine was shown to reduce the postoperative pain and ed. in addition it is generally accepted that that postoperative ed can be reduced with good analgesia. local infiltration of peritonsillar fossa with various local anesthetics, steroids etc. is an established technique for relieving the postoperative pain. bupivacaine as a long-acting local anesthetic is widely used for local infiltration anesthesia. it is a safe technique and several comparative studies exists in the literature on efficacy. a few number of studies exists that evaluates the relationship between effective pain control and postoperative ed development in children with regional anesthesia applications. however, in english literature we could not find a study on the effect of local infiltration of peritonsillar fossa on development of ed in subjects who underwent tonsillectomy/adenotonsillectomy operations. the aim of this study is to evaluate the effect of peritonsillar bupivacaine infiltration on the development of postoperative delirium in pediatric patients undergoing tonsillectomy/adenotonsillectomy.

Eligibility criteria:
inclusion criteria: * patient have adenotonsillectomy * age 3-7 years * asa-1 exclusion criteria: * active infection, * bleeding-coagulation disorder, * neuropsychiatric disorder, * bupivacaine hypersensitivity, * postoperative delirium history, * history of surgery for different reasons within 1 year, * history of long-term hospitalization, * chronic disease, * chronic pain condition * chronic analgesic use

Keywords: emergence delirium tonsillectomy bupivacaine infiltration analgesia postoperative pain
evaluation of a primary care weight management program in children aged 2 to 5 years

Conditions: Childhood Obesity; Feeding Behavior; Physical Activity

Summary: primary care offers a promising setting for promoting parenting practices that shape healthy eating and physical activity behaviors of young children. this study assessed the impact of a parent-based, primary care intervention on the feeding habits, health behaviors, and body mass index (bmi) of 2-5 year olds with elevated or rapidly-increasing bmi. four private pediatric offices in west michigan were assigned as control (n=2) or intervention (n=2) sites based on patient load and demographics. treatment families were recruited at well-child visits to receive physician health-behavior counseling and four visits with a registered dietitian nutritionist (rdn) over a 6-month period. outcomes included percent of the 95th bmi percentile (%bmi95), the family nutrition and physical activity survey (fnpa), and the feeding practices and structure questionnaire (fpsq).


Eligibility criteria:
inclusion criteria: * age between 2 and 5 years * bmi ≥85th percentile for age and sex, using the 2000 cdc growth chart, or bmi percentile increase within the past year equivalent to crossing at least two growth chart lines per year on a standard cdc growth chart, excluding the 5th percentile (e.g., 10th \& 25th, 25th \& 50th, 50th \& 75th, 75th \& 85th). this rate of increase is equivalent to ≥0.67 standard deviations per year (bmi z-score), and, when occurring in this age group, has been shown to increase risk of adult obesity exclusion criteria: * known disorder of the hpa axis * use of glucocorticoid medication * non-english speaking

Keywords: pediatric obesity preschool children non-responsive feeding body mass index parenting
adjuvant stereotactic body radiation therapy after trans-arterial chemoembolization in hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma Non-resectable

Summary: the study investigates the adjuvant sbrt following tace in early and intermediate stages hcc not amenable for surgical resection or orthotopic liver transplant.


Eligibility criteria:
inclusion criteria: * hcc (diagnosis: histological or radiological) * age: 18-80 * number of lesions 1-3 lesions * size of the lesion (or sum of 2-3 lesions) ≥ 4 cm * sufficient non-tumorous liver volume (≥ 800 cm3) * child pugh score: a5-6 or b7-8 * bclc a or b * patient is illegible or refused surgical resection or orthotopic liver transplant * blood work (within 2 weeks before registration): * absolute neutrophil count (anc) ≥ 1,500 cells/mm³) * platelets ≥50,000 cells/mm³ * ast (and alt) \< 5 times uln * serum creatinine ≤ uln or creatinine clearance ≥ 50 ml/min exclusion criteria: * evidence of extrahepatic disease (lymph node or distant metastases) * evidence of macroscopic vascular invasion * evidence of an arterio-portal or arterio-venous fistulas * history of previous malignancy * previous sirt * previous sorafenib in the last 8 weeks * pregnant and lactating females
mhealth behavior study

Conditions: Alcohol Consumption; Condom Use

Summary: the goal of this clinical trial is to learn if a brief task completed on a smartphone can reduce alcohol use and risky sexual behavior among women between the ages of 18 and 25 who have a history of experiencing sexual assault or an unwanted sexual experience. the main questions it aims to answer are: * does the smartphone task change approach biases for alcohol and condom-related images? * does the smartphone task reduce alcohol use and risky sexual behavior? researchers will compare the smartphone task to a sham control to see if the smartphone task changes biases and behavior. participants will: * complete a baseline assessment battery of questionnaires * complete either the intervention smartphone task or the sham smartphone task on four consecutive days. * complete a follow-up assessment one week after finishing the four tasks * complete a three-month follow-up


Eligibility criteria:
inclusion criteria: * adult women who report lifetime experience sexual assault, * consume alcohol at least moderately (e.g., at least seven drinks per week; niaaa, 2015), * have engaged in sexual intercourse with a casual, non-committed male partner without a condom at least three times during the three months prior to data collection. exclusion criteria: * active homicidal or suicidal ideation; * history of or current psychotic disorders as the study protocol may be therapeutically insufficient; * previously identified as having a pervasive developmental disability.

Keywords: alcohol condoms sexual assault risky sex
feasibility study of the instrumented evaluation of eccentric strengthening in paresis patients

Conditions: Paralysis

Summary: he aim of the "re par ex" research is to evaluate the feasibility of the instrumented examination of the effects of eccentric muscle strengthening in paralytic patients. this project is part of the research axis of the movement analysis laboratory. following a stroke or spinal cord injury, patients develop a spastic paresis syndrome, which is characterized by the appearance of paresis, musculo-tendinous retractions and muscular hyperactivities. if the traditional treatments proposed (stretching, motor work) show limits, the use of eccentric muscle strengthening in paresis patients has been developing for about ten years, with results superior to the usual treatments. the results of the studies evaluating it are focused on clinical evaluations and do not make it possible to identify the precise origin of the observed responses. a pathophysiological understanding of the therapeutic effects of eccentric strengthening would be possible through instrumented examination of muscle structure and function, combining dynamometry, ultrasound, elastrography and electromyography (emg). however, the feasibility of this quantified instrumental examination in paretic patients during a strengthening protocol has not been evaluated. the feasibility of a quantified instrumented examination in this setting is the aim of this research, a necessary prerequisite for a larger interventional study to evaluate the biomechanical and neurophysiological effects of eccentric muscle strengthening in paretic patients.


Eligibility criteria:
inclusion criteria: * patient aged 18 to 80 years; * validation by the medical team of an eccentric strengthening protocol: presence of a paresis of the studied muscle considered as functionally (triceps surae rated at 2 or more on the mrc scale), more or less associated with ham and muscl retraction; * patient with a traumatic or ischemic spinal cord injury of grade asia impairment scale (ais) c or d (incomplete motor impairment) \< 6 months or stroke \< 6 months; * patient is competent to consent (boston diagnostic aphasia examination \[bdae\] score greater than or equal to 2); * patient hospitalized in the neurological prm service of the nantes university hospital. exclusion criteria: * history of functional surgery \< 3 months ; * patient with osteoarticular lesions considered as a contraindication to to rehabilitation; * patient who is unlikely to adhere to the study program and/or not compliant compliant in the judgment of the investigator or refusing to participate in the study; * patients with a progressive pathology that contraindicates major muscular efforts (syrinx, cancer, etc.) (syrinx, cancer, cardiovascular instability...); * patients who are minors, protected adults, adults unable to express their consent or pregnant woman.
a study to evaluate impact of efanesoctocog alfa on long-term joint health in participants with hemophilia a in taiwan

Conditions: Hemophilia A

Summary: this is a national, multicenter, retrospective/prospective, observational study in taiwan designed to assess effectiveness, safety, and usage of efanesoctocog alfa prophylaxis treatment in hemophilia a participants. the data related to efanesoctocog alfa effectiveness, safety and usage will be recorded prospectively during routine visits for up to 5 years following enrollment initiation and the retrospective data will be collected at least 12 months and up to 24 months prior to efanesoctocog alfa initiation. joint imaging data will be collected in centers performing joint u/s and/or mri (≥6 years old). at least 12 months of retrospective data will also be collected from medical records, as available. prospectively collected data will be recorded at routine clinical visits during a five-year follow-up period. the end of study is defined as the last participant's last visit. no intervention will be administered, and no study related visits are required.


Eligibility criteria:
inclusion criteria: * participants with all ages and diagnosis of moderate-severe hemophilia a without current and/or at least three years of un-detectable inhibitor (\<0.6 bu) * participants with moderate to severe hemophilia a as defined by fviii level ≤ 5% * participants starting efanesoctocog alfa prophylaxis treatment as per standard of care no more than three months prior to the enrollment date * participants aged 6 years and older are able to undergo mri examinations (sedation given, if necessary, and per investigator discretion) * participants are able to undergo joint examinations * physician's decision to treat the participant with efanesoctocog alfa is made prior to and independently of participation in the study * signed and dated informed consent provided by the participant, or by the participant's legally acceptable representative for participants under the legal age before any study-related activities are undertaken. assent should be obtained for pediatric participants according to local regulations exclusion criteria: * participants with coagulation disorders other than hemophilia a * participants diagnosed with other known bleeding disorder * participants currently receive factor therapy and have signs of decreased response to fviii therapy * participants with a baseline radiological pettersson score (ps) of greater than 6 for each individual ankle * enrollment in another concurrent clinical interventional study, or intake of an investigational medicinal product within 3 months prior to inclusion in this study * pregnant female participants the above information is not intended to contain all considerations relevant to a potential participation in a clinical trial.

Keywords: classic hemophilia factor viii deficiency haemophilia hemophilia hemarthrosis blood coagulation disorders, inherited hematologic diseases coagulation protein disorders hemorrhagic disorders genetic diseases, inborn
evaluation of the effects of mefenamic acid and dexketoprofen on postoperative wisdom dental surgery

Conditions: Tooth, Impacted; Tooth Diseases

Summary: this study was administered to 22 female and 8 male patients. patients with impacted wisdom teeth on both sides of the mandible were selected. after impacted tooth extraction, the patient used mefenamic acid on one side and dexketoprofen on the other side for postoperative pain relief. the effects of these two materials on patient comfort were investigated.

the aim of this study; to compare the effects of dexketoprofen and mefanamic acid on pain, edema and trismus after lower impacted wisdom teeth surgery. 60 impacted wisdom teeth in 30 healthy individuals who applied to van yüzüncü yıl university, faculty of dentistry, department of oral and maxillofacial surgery with an indication for extraction of impacted lower wisdom teeth were included in the study. 60 impacted wisdom teeth belonging to individuals were randomly divided into two groups (a and b). in a randomized, controlled, double-blind study, dexketoprofen (a) and mefanamic acid (b) were given to patients immediately after surgery. vas (visual analog scale) was used for pain assessment and assessment was made at 3, 6, 12 and 24 hours and 2, 3, 4, 5, 6 and 7 days. for the evaluation of edema, the facial measurements of the patients before the operation were recorded and repeated on the 2nd and 7th postoperative days. preoperative maximum mouth opening measurement for trismus assessment was repeated on the 2nd and 7th postoperative days and recorded.

Eligibility criteria:
inclusion criteria: * volunteers with bilateral fully impacted mandibular wisdom teeth exclusion criteria: * patients were excluded from the study if they did not understand the clinical procedures of the study, * had allergies or intolerance to any of the substances used in the study, * patients on anticoagulant or psychiatric treatment, * pregnant or breastfeeding, * patients using oral contraceptiveswere, * diabetic, * patients with periodontal disease or active infection, * poor oral hygiene

Keywords: impacted wisdom teeth dexketoprofen mefenamic acid
atomoxetine to treat adolescents with coexisting alcohol and other substance use disorder and adhd

Conditions: Substance Use Disorders; Attention Deficit Hyperactivity Disorder

Summary: the purpose of this study is to compare the effectiveness and safety of atomoxetine in the treatment of adolescents with coexisting alcohol or substance use disorders and attention deficit hyperactivity disorder (adhd).


Eligibility criteria:
inclusion criteria: * adolescents, ages 13-18 * meets criteria for alcohol and/or substance use disorder and attention deficit hyperactivity disorder. exclusion criteria: * adolescents who are pregnant. * have a history of seizure disorder, other neurological or medical disorder for which medication treatment may present a considerable risk. * history of pervasive development disorder, schizophrenia or other psychotic disorders, organic mental disorders or eating disorders. * currently on other psychotropic medications from which discontinuation would present a significant risk. * a current episode of major depressive disorder or a diagnosis of bipolar disorder. * diagnosis of dependence for any substance other than marijuana. * adolescents with a full-scale iq below 80.

Keywords: adhd substance use
an observational study for analysis of mortality in participants who participated in previous 3 studies of galantamine

Conditions: Mild Cognitive Impairment

Summary: the purpose of the study is to collect data of patients who were randomized (assignment of study medication by chance) and treated in 3 previous studies of galantamine (cr003145, cr002014 and cr005947) for the treatment of mild cognitive impairment (isolated memory impairment). this data were not recorded during the course of these 3 previous studies.

the objective of this observational study is to ascertain follow-up vital status data for patients who were randomized (assignment of study medication by chance) and treated with galantamine or placebo in 3 previous studies (cr003145, cr002014 and cr005947). this study is designed to evaluate the imbalance of deaths that were initially recorded in the double-blind (neither physician nor patient knows the treatment that the patient receives) phases of two of these studies. data will be combined from three sources: the databases of the 3 previous studies, forms from investigators, and data acquired during the present study. investigator will obtain consent from the patients or their informant for participating in the study. data on vital status will be obtained either from the patient or informant after obtaining informed consent. if a patient does not provide informed consent, documentation of contact with the patient will suffice as evidence that the patient is alive. if an informant does not provide informed consent or a patient cannot be contacted, medical or death records or death registers will be consulted when necessary to determine if a death occurred. if a patient was found to have died, the investigator records the cause of death, date of death, and the adverse events (unwanted consequence that occurs during the course of the clinical study, but not necessarily because of study medication) leading to death, by a review of medical records, autopsy records, and/or death certificates.

Eligibility criteria:
inclusion criteria: * all patients who were randomized and treated with galantamine or placebo in 3 previous studies (cr003145, cr002014, and cr005947) exclusion criteria: * patients not enrolled in above referenced studies

Keywords: mild cognitive impairment dementia galantamine memory disorders isolated memory impairment alzheimer's disease