Kornimate/medical-research-clean huggingface dataset:
efficacy of fecal microbiota transplantation (fmt) in irritable bowel syndrome (ibs)

Conditions: Irritable Bowel Syndrome

Summary: the goal of this clinical trial is to determine efficacy of fmt via rectal enema and encapsulated fmt in patients with ibs in thailand. the main question it aims to answer is: • does fmt provide better efficacy than placebo in ibs patients? participants will be randomized into 3 groups: * in placebo group, patients will receive placebo capsules and placebo via enema. * in enema group, patients will receive placebo capsules and fmt via rectal enema. * in capsule group, patients will receive fmt capsules and placebo via rectal enema. researchers will compare fmt and placebo group to see if using fmt provides better efficacy for ibs patients than placebo. moreover, researchers will compare efficacy of fmt capsules and fmt via rectal enema in ibs patients.

irritable bowel syndrome (ibs) is a common functional bowel disorder defined by recurrent abdominal pain related to defecation or a change in bowel habit (1). pathogenic mechanisms of ibs include gut microbial dysbiosis, low-grade mucosal inflammation, increased gut permeability, and altered gut-brain interaction (2). dysbiosis is an imbalance of gut microbiota which can contribute to ibs. emerging treatment approach for ibs aims to correct dysbiosis by modulation of intestinal microbiota (3). fecal microbiota transplantation (fmt) is an administration of feces from a healthy donor to the gastrointestinal tract of a recipient in order to restore balanced microbial flora (4). correcting gut dysbiosis might be another target to improve ibs symptoms. some previous randomized controlled trials demonstrated that fmt could provide clinical response in patients with ibs (5-7), whereas others reported no different outcome from placebo (8, 9). most trials delivered fmt via more invasive routes such as colonoscopy or gastroscopy. there were few studies using less invasive methods, e.g., oral fmt capsules and fmt via rectal enema. less invasive routes of fmt administration are needed to be evaluated so as to reduce risk and cost of endoscopy. this study aimed to determine efficacy of fmt via rectal enema and encapsulated fmt compared with placebo in ibs patients in thailand.

Eligibility criteria:
inclusion criteria: * patients aged 18-70 years with ibs diagnosed by rome iv criteria * patients who can provide written informed consent. exclusion criteria: * pregnant or breastfeeding women * severe comorbidities: chronic kidney disease (gfr\<15 ml/min), cirrhosis, cancer, etc. * fecal incontinence * immunocompromised patients * taking probiotic, or fermented food * discontinue medication for ibs \<1 month prior to study inclusion

Keywords: fecal microbiota transplantation
sentinel lymph node in early ovarian cancer

Conditions: Ovarian Cancer

Summary: this research study evaluates the concordance of the result between two diagnostic tests: sentinel node and pelvic-para-aortic lymphadenectomy in patients with ovarian cancer.

the objective of this study is to describe the feasibility of performing the sentinel node technique (detection rate) in patients with early stage ovarian cancer. with this research study it will be evaluated the concordance of the result between two diagnostic tests: sentinel node and pelvic-para-aortic lymphadenectomy in patients with ovarian cancer.

Eligibility criteria:
inclusion criteria: * informed consent signed previously to performing any procedure related to the clinical trial. * patients who are women 18 years of age or older at the moment of the randomization. * patients with anatomopathological diagnosis of malignant ovarian tumor in a deferred study proposals for staging surgery or patients with suspicious tumor of malignancy who are going to be subjected to exploratory lapaotomy or laparoscopy and operative biopsy, and in the case this is positive, surgery of staging will be performed . exclusion criteria: * informed consent not obtained or withdraw. * benign result in extemporaneous study * previous history of vascular surgery in the aorta, cava or pelvic vessels * previous pelvic or para-aortic lymphadenectomy * previous lymphoma * previous abdomino-pelvic tumor * previous allergic reaction to indocyanine green * pregnancy / lactation * severe adherent syndrome

Keywords: sentinel lymph node
rotator cuff surgical outcomes in women

Conditions: Injury of Shoulder Region; Rotator Cuff Syndrome

Summary: the overall purpose of this work is to use a prospective cohort study to examine patient-specific but shoulder-extrinsic factors and how they influence the results of rotator cuff surgery. there are undoubtedly many factors that play a role in patient outcome, however, this project will focus on three: the effect of gender on outcome, the effect of mood disorders and coping style on outcome, and the effect of patient height and reach on outcome after rotator cuff surgery. it is hypothesized that these factors will have a significant influence over outcomes.


Eligibility criteria:
inclusion criteria: * referred for surgical treatment of predominantly unilateral rotator cuff syndrome exclusion criteria: * unable to speak or read english * unable to complete 12 month follow-up * significant cervicogenic arm and shoulder pain in the affected arm * significant chronic pain diagnoses felt at least as likely to be the cause of the symptoms as the rotator cuff condition as evaluated by the surgeon

Keywords: rotator cuff shoulder reconstruction
sunosi® (solriamfetol) pregnancy registry

Conditions: Narcolepsy; Obstructive Sleep Apnea; Pregnant Women and Their Offspring

Summary: the sunosi (solriamfetol) pregnancy registry is a prospective, multi-country, observational study to evaluate the safety of solriamfetol exposure during pregnancy in women with a diagnosis of narcolepsy or obstructive sleep apnea (osa).

the goal of the registry is to provide information on the safety of solriamfetol during pregnancy so that patients and physicians can weigh the benefits and risks of exposure during pregnancy and make informed treatment decisions. the study collects health information from enrolled pregnant women and their healthcare providers related to their pregnancies and developing babies up to 1 year of age. the registry is strictly observational. only data that are routinely documented in patients' medical records during the course of usual care will be collected.

Eligibility criteria:
inclusion criteria: * pregnant women of any age * diagnosed with narcolepsy or obstructive sleep apnea or has taken solriamfetol or other wake promoting medications or stimulants during pregnancy * resident of a country where solriamfetol is available for the treatment of excessive daytime sleepiness (eds) associated with narcolepsy or osa * provides written informed consent to participate in the study * authorization for her hcp(s) to provide data to the registry exclusion criteria: * occurrence of pregnancy outcome prior to first contact with the registry coordination center (rcc) * inclusion of a prior pregnancy in the main analysis population

Keywords: solriamfetol sunosi axsome narcolepsy obstructive sleep apnea non-stimulant therapy dopamine norepinephrine reuptake inhibitor pregnancy outcomes infant outcomes
impact of age on the prevalence of allergic sensitization

Conditions: Allergy

Summary: worldwide, respiratory diseases have a significant impact on morbidity and mortality of individuals.tobacco, lifestyle and certain allergens such as dust mites play an important role in the prevalence and morbidity of these diseases. scientific literature indicates that sensitization to allergens and respiratory diseases (asthma, rhinitis, chronic obstructive pulmonary disease) are closely linked. moreover, smoking has an effect on allergen sensitivity. to make a diagnosis of allergic sensitization, skin tests are performed in the patient. one of the methods used is the technique of "prick test". in practice, a drop of purified allergen extract is placed on the patient's skin (arms or back). a little dosis of the product is then injected in the epidermis. if fifteen minutes later, there is an edematous reaction, its diameter is measured in millimeters. from 4 mm, it is considered that the patient is sensitized to the tested foods or allergens.this technique is painless and convenient to patients of all ages, including newborns or conversely very aged patients. this is a retrospective study based on the encoding and statistical analysis of data collected in patients followed within the immuno-allergology service of the chu brugmann hospital, who received an allergy assessment between 01/01/2015 and 31/12/2015. the allergens tested include: dermatophagoides pteronyssinus (dept), dermatophagoides farinae (dpf), blomia, cat, dog, cockroach, orchardgrass, timothy grass, alder, hazel,birch, olive tree, cypress, ash, latex, aspergillus, alternaria, cladosporium, peanut, hazel. at least 1400 files will be analyzed. patients will be distributed in six age groups.the results of the allergen skin tests will be encoded as the edema diameter. the allergenicity score (mean of the skin reactivities for each allergen) will be compared between each age groups. the impact of tabagism, gender, bmi and residential area on the allergic reactivity will also be assessed in the overall population and within each age group. the main objective is to evaluate the effect of age on the skin test positivity. the secondary objective is to highlight the environmental factors that have an impact on allergic diseases.


Eligibility criteria:
inclusion criteria: * all patients followed within the immuno-allergology service of the chu brugmann hospital * who received an allergy assessment between 01/01/2015 and 31/12/2015. the allergens tested include: dermatophagoides pteronyssinus (dept), dermatophagoides farinae (dpf), blomia, cat, dog, cockroach, orchardgrass, timothy grass, alder, hazel,birch, olive tree, cypress, ash, latex, aspergillus, alternaria, cladosporium, peanut, hazel. exclusion criteria: * negative histamine patients

Keywords: respiratory disease allergen sensitization aging skin tests air allergens
improving veteran access to integrated management of back pain

Conditions: Low Back Pain; Veterans Family

Summary: the purpose and objective of this pragmatic trial is to examine the effectiveness of two different quality improvement care pathways for low back pain (lbp); a sequenced, integrated care pathway (icp) and 2) a coordinated, care management pathway (ccp). we will test the central hypothesis that the icp will reduce pain interference with normal activities and improve physical function, as measured by patient reported outcomes measurement information system (promis) short form scores when compared to the ccp.


Eligibility criteria:
clinic eligibility: * volunteer and return signed clinic participation agreement * availability of clinical personnel willing to deliver the treatment interventions (in either arm). * staff and location need to be distinct from other enrolled clinics. * clinics can have a variable number of providers, but together meet criteria for range of monthly visits for low back pain. participant survey eligibility criteria: inclusion criteria: 1. age \>= 18 2. seeking care for lbp with or without radiating symptoms from a participating va primary care clinic 3. provider determines lbp is appropriate for conservative management 4. referred to integrated icp pathway or ccp pathway by participating clinic provider exclusion criteria: 1. receiving or referred for hospice/ palliative care (defined by encounter codes and cprs consults) 2. no documented phone number in the electronic health record.

Keywords: clinical pathway veterans low back pain
hepatitis delta virus infection: cross-sectional study in patients with chronic hepatitis b virus infection

Conditions: Hepatitis Delta With Hepatitis B Carrier State; Chronic Hepatitis b

Summary: the goal of this observational study is to determine the prevalence of hepatitis d virus (hdv) and the distribution of the hdv genotype in patients with chronic hepatitis b infection. it will also identify factors related to hepatitis d virus infection, such as characteristics of the study sample, vaccination history, drug use affecting hepatitis, family factors, environment, and lifestyle. this study will be conducted at tam anh general hospital, bach mai hospital and tam anh tp. ho chi minh general hospital. participants will be interviewed directly through a questionnaire to collect some information related to epidemiological risk factors. a blood sample will also be collected.


Eligibility criteria:
inclusion criteria: * patients ≥ 16 years old undergo testing at the testing center of tam anh general hospital or tam anh tp. ho chi minh general hospital, with chronic hepatitis b hbsag (+) standards for six months or over or hbsag (+) combined with hbcab total (+) and hbcab-immunoglobulin m (-). * patients ≥ 16 years old with chronic hepatitis b come to be examined or are inpatients at the gastroenterology - hepatobiliary center of bach mai hospital, diagnosed with hepatocellular carcinoma, and cirrhosis exclusion criteria: * patients do not agree to participate in the study or refuse to sign a written informed consent.
usefulness of lidocaine in oral and maxillofacial surgeries under general anesthesia for pain control after operation

Conditions: Pain, Postoperative

Summary: this will be a randomized double blinded clinical study conducted in patients undergoing oral and maxillofacial surgery under general anesthesia. lidocaine group will receive intravenous bolus 1.5 mg/kg at induction followed by continuous infusion of 2 mg/kg/hr until the completion of surgery.normal saline group will receive same amount of intravenous normal saline .the primary outcome will be postoperative pain using the nrs scale during first 24 hours and time to first analgesic request


Eligibility criteria:
inclusion criteria: * adult patients 18-60 years of age * patients of asa (american society of anesthesiologists) class i or class ii (i- healthy with no systemic disease, ii- mild systemic disease with no functional limitation) who require oral and maxillofacial surgeries under general anesthesia exclusion criteria: * refusal to give consent. * hypersensitivity or allergy to the study medication. * asa physical status iii or more. * subjects with known severe hepatic or renal dysfunction or cardiac dysrhythmia or atrioventricular block. * history of taking opioids or antiarrhythmic drugs within 1 week of surgery. * history of drug or alcohol abuse * history of psychiatric disorders. * patients requiring emergency surgery. * patients unable to comprehend pain assessment
prevalence and impact of diabetes mellitus in hospitalized covid-19 patients in a tunisian center

Conditions: Prevalence; Diabetes Mellitus; Impaction; COVID-19

Summary: objective: the objective of this study was to evaluate the prevalence and impact of diabetes mellitus on the severity and mortality of covid-19. methods: data of laboratory-confirmed hospitalized patients at the covid-19 unit of ibn el jazzar university hospital in kairouan between september 2020 and august 2021 were analysed, in a cross-sectional study. the population was classified into two groups (covid-19 patients with versus without diabetes). primary outcomes were the overall length of hospital stay, the admission to the intensive care unit (icu), and death.

the outbreak of the coronavirus disease 2019 (covid-19) has become an evolving worldwide health crisis. with the rising prevalence of diabetes mellitus has come an increasing awareness of their impacts on infectious diseases, and the risk for post-infection complications and mortality from critical infections. objective: the objective of this study was to evaluate the prevalence and impact of diabetes mellitus on the severity and mortality of covid-19. methods: data of laboratory-confirmed hospitalized patients at the covid-19 unit of ibn el jazzar university hospital in kairouan between september 2020 and august 2021 were analysed, in a cross-sectional study. the population was classified into two groups (covid-19 patients with versus without diabetes). primary outcomes were the overall length of hospital stay, the admission to the intensive care unit (icu), and death. association between diabetes and death was assessed in a cox proportional hazards model.

Eligibility criteria:
inclusion criteria: confirmed cases indicated the patients whose real-time reverse transcriptase-polymerase chain reaction (rt-pcr) analysis results for nasal swab specimens were positive. exclusion criteria: * the investigators didn't included patients who were suspected cases, and whose the result of pcr test was negative ; covid-19 patients admitted in other departments (cardiology, pediatrics, obstetrics, intensive care unit, medicine, surgery department...) ; and patients with missing medical records. -

Keywords: diabetes mellitus death complications covid-19 sars-cov2 intensive care units tunisia
efficacy of adding topiramate to current treatment in refractory obsessive compulsive disorder (ocd)

Conditions: Obsessive Compulsive Disorder

Summary: sri's are considered first-line treatments for ocd, however many patients continue to have significant symptoms despite an adequate trial of an sri. neuroimaging studies have shown that the glutamate neurological system is involved in ocd. this study will test the safety and efficacy of topiramate, a drug, which targets glutamate, in the treatment of ocd, where the ocd has been un-responsive, or partially responsive to regular sri treatment.


Eligibility criteria:
inclusion criteria: * outpatient with primary dsm- iv ocd * completion of a 14-week open label trial of one the following sri's: fluoxetine 80 mg/day, paroxetine 60 mg/day, fluvoxamine 300 mg/day, clomipramine 250 mg/day, sertraline 200 mg/day, citalopram 60 mg/day, escitalopram 30 mg/day and demonstrating a non or partial responses to sri treatment (cgi-i of 3 or 4, y-bocs reduction of \< 35%) * stable (8 wks or longer) concurrent medications including benzodiazepines, sedative hypnotics, antipsychotics, and antidepressants. exclusion criteria: * any other primary dsm-iv diagnosis; dsm-iv criteria for body dysmorphic disorder, bipolar affective disorder, schizophrenia, psychotic disorder, current alcohol/substance abuse. * a previous adequate trial of topiramate * comorbid major depressive disorder diagnosis which predates ocd diagnosis * cognitive behavioural therapy or additional psychotherapy in past four months * allergy or hypersensitivity to topiramate * bmi \< 20 * history of kidney stones

Keywords: treatment refractory obsessive compulsive disorder
efficacy of daily vitamin d3 supplementation in normal weight adolescents

Conditions: Vitamin D Deficiency

Summary: the study is designed to evaluate the increment of serum 25 (oh) vitamin d levels in normal weight adolescents following a 12-week supplementation with vitamin d3 2000 iu/day.

twenty normal weight adolescents between ages 12-18 that are age and gender would receive vitamin d3 supplementation at a dose of 2000 iu/day. levels of 25(oh)vitamin d would be measured at baseline and after 12 weeks.relationship between 25 oh vitamin d levels and other demographic variables will be assessed.the primary endpoint in this study is the 25 oh vitamin d level at 12 weeks.

Eligibility criteria:
inclusion criteria: * subjects between ages 12 and 18 years with bmi between the 5th and the 85th percentile for age and gender. exclusion criteria: * subjects with 25 (oh)- d levels \>80 ng/ml * serum calcium \>10.8 mg/dl * serum phosphorus \> 5.5 mg/dl * pregnancy or nursing * current cancer * patients on multivitamin supplementation * dietary calcium intake exceeding 1500 mg/day * hepatic or renal disorders * type 1 or type 2 diabetes mellitus * those receiving insulin, metformin, or oral hypoglycemic medications * malabsorption disorders (celiac disease, cystic fibrosis, inflammatory bowel disease)

Keywords: vitamin d supplementation adolescence
writing about disease: effect on rehabilitation?

Conditions: COPD; Asthma

Summary: therapeutic writing about one's emotions has been described previously (j pennebaker: emotions, disclosure and health. am psychol. assoc 1995). the present project will compare the effects (if any) of writing about the emotional versus the physical consequences of lung disease on anxiety, perceived quality of life, and perceived health status.

chronic obstructive pulmonary disease (copd) patients (age 35-70) and asthma patients (age 20-60) referred to a 4 weeks inpatient rehabilitation program - who agree to participate in the project - are randomly assigned to one of three conditions: * writing about emotional consequences of their disease before the program starts * writing about physical consequences of their disease before the program starts * not writing all patients are measured (completing questionnaires at home) on: perceived quality of life, perceived health status and trait anxiety - 2 weeks before the program, 2 weeks after the program and 6 months after the program. fev1 and 6 min walking distance are measured at the beginning and by the end of the program. in addition to questionnaires, all patients are asked to: * write in their own words ( 2 weeks after) to evaluate their stay at the rehabilitation clinic; and * write in their own words (6 months after) about how the disease affects their life at that point. both quantitative and qualitative data will be used for analysis purposes.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of copd (age between 35 and 70) * clinical diagnosis of asthma (age between 20 and 60)

Keywords: copd asthma qol perceived health status trait anxiety