Kornimate/medical-research-clean huggingface dataset:
frailty syndrome of post-cancer treatment eldery patients

Conditions: Frailty Syndrome; Exercise; Nutritional Support; Cancer

Summary: decrease the prevalence of frailty syndrome in individuals with complete response of cancer.


Eligibility criteria:
inclusion criteria: * in complete remission from cancer (all type of cancer) * have a frailty syndrome (positive gfst score) * ability to provide signed informed consent * be affiliated with social security or beneficiary of such a scheme exclusion criteria: * patient with active cancer or any other pathology affecting the prognosis at 5 years * currently participating or having participated in the month preceding inclusion in another interventional clinical research that may impact the study. this impact is left to the investigator discretion * subjects referred to articles l1121-5 to l1121-8 of csp (corresponds to all protected persons: person deprived of liberty by judicial or administrative decision, person subject to legal protection measure)
monomax for abdominal wall closure

Conditions: Abdominal Wall Wound

Summary: a great number of different suture techniques and suture materials are in use in order to reconstitute the abdominal wall integrity, but there is no surgical gold standard for abdominal wall closure until today. various meta-analyses and randomized controlled trials have been performed, which compared non-absorbable or long-term absorbable versus rapid absorbable suture materials or monofilament versus multifilament suture materials, or continuous versus interrupted suture techniques respectively. this lack of evidence has the following outcome: burst abdomen is observed in 1-3% of patients within the first days after a laparotomy. the incidence of abdominal wall hernias 12 months postoperatively is estimated to be up to 20% (range 9 to 20%) . wound infections develop in 3 to 21% of patients undergoing a median laparotomy within the first 30 days. at present most surgeons favour monofilament long-absorbable continuous sutures as the most suitable material for closing abdominal wounds after midline laparotomy.


Eligibility criteria:
inclusion criteria: * age 18 years and older * elective primary laparotomy * written informed consent exclusion criteria: * peritonitis * emergency surgery * severe psychiatric and neurologic disease * drug- and / or alcohol abuse according to local standard * lack of informed consent * current immunosuppressive therapy * chemotherapy within the 2 weeks before operation * radiotherapy of the abdomen completed less than 8 before surgery * pregnant or breast-feeding women * coagulopathy

Keywords: laparotomy surgical procedures, elective sutures abdominal wound closure techniques
efficacy and safety of tofacitinib in psoriatic arthritis: comparator study

Conditions: Psoriatic Arthritis

Summary: this is a 12-month study investigating the effectiveness and safety of tofactinib in treating the signs and symptoms of active psoriatic arthritis and improving physical function and preserving bone structure in patients with an inadequate response to a traditional, nonbiologic disease-modifying antirheumatic drug. adalimumab is used as a comparator.


Eligibility criteria:
inclusion criteria: * males or females, aged \>= 18 years at time of consent. * have a diagnosis of psoriatic arthritis (psa) of \>= 6 months * meet the classification criteria of psa (caspar) at time of screening * must not have been adequately treated with a a traditional non-biologic disease modifying anti-rheumatic drug (dmard). * concurrent treatment with methotrexate, leflunomide, or sulfasalazine allowed and required * must not have taken a biologic tumour necrosis factor inhibitor * must have 3 or more swollen joints and 3 or more tender joints * must have active psoriasis skin lesions exclusion criteria: * have non-plaque forms of psoriasis, eg erythrodermic, guttate or pustular, with the exception of nail psoriasis which is allowed * pregnant or breast feeding, females of child-bearing potential not using highly effective contraception * new york heart association class iii and iv congestive heart failure * history of hypersensitivity or infusion reaction to biologic agents * infection with hiv, hepatitis b virus, hepatitis c virus, or other chronic infection

Keywords: psoriatic arthritis radiographic changes active comparator tofacitinib
tb-capt mtb/xdr study

Conditions: Tuberculosis; Resistance Bacterial; Diagnoses Disease

Summary: the cepheid xpert mtb/xdr cartridge, which runs on the same platform as xpert mtb/rif ultra, has been developed to detect additional resistance to isoniazid, fluoroquinolones and second-line injectable anti-tuberculosis drugs and provides results within 2 hours and on primary samples. an evaluation of the the xpert mtb/xdr assay is currently underway in clinical settings in south africa, india and moldova. the tb-capt mtb/xdr study will add further diagnostic accuracy and feasibility data to the evidence base for the xpert mtb/xdr assay.


Eligibility criteria:
inclusion criteria: * mtb-positive, rifampicin-resistant respiratory specimen identified on xpert mtb/rif ultra exclusion criteria: * residual sr-sputum mix not retained or not found * patient previously included in the study exclusion for diagnostic accuracy and time-to-result endpoints: * insufficient residual sr-sputum mix remaining for xpert mtb/xdr (\<2 ml) * xpert mtb/xdr unsuccessful * no second / follow-up specimen received * second / follow-up specimen culture-negative, contaminated or not available * reference standard uninterpretable (phenotyping or wgs) * where phenotypic susceptibility testing results are uninterpretable, specimens will still be included in wgs comparison * where wgs results are uninterpretable, specimens will still be included in phenotypic susceptibility testing comparison
sleep quality response to resisted training after coronary artery bypass grafting

Conditions: Sleep Deprivation

Summary: background:there are still many gaps in research concerning the effect of different physical training modalities on sleep quality in the population underwent coronary artery bypass graft surgeries(cabg).purpose:the present study was conducted to compare the quality of sleep in subjects who underwent cabg, were submitted to two types of training (i.e, aerobic exercise alone or combined aerobic and resistance training

objective/background: there are still many gaps in research concerning the effect of different physical training modalities on sleep quality in the cardiac population. thus, the objective of the present study was to compare the quality of sleep in subjects who underwent coronary artery bypass surgery submitted to two types of training (ie, aerobic exercise alone or combined aerobic and resistance training). patients/methods: 80 participants aged 45-65 years were randomized to two groups: aerobic group (ag), combined aerobic and resistance group (arg). training lasted ten consecutive weeks with 30 uninterrupted sessions. the actigraph (actiwatch minimitter company, incorporated (inc) - sunriver, or, usa) was placed on the non-dominant wrist and activities were monitored continuously while being recorded at one minute intervals. the participants kept the device for a period of 96 hours before the first and last training sessions.

Eligibility criteria:
inclusion criteria: 1. patients who have underwent cabg surgery since 6-8 weeks 2. their ages ranges from 40 and 80 years of age 3. medically stable patients. 4. patients did cabg-only treatment (not combined with valve replacement surgery) 5. current complaint of poor sleep quality (sq) (score \> 5 of the sq scale) 6. body mass index ≤ 35 kg/m2 (no obstructive sleep apnea) exclusion criteria: 1. any patient is known to have any unstable medical condition 2. history of chronic insomnia for at least one year before surgery 3. indication of receiving treatments for depression and anxiety 4. musculoskeletal or neurological conditions that might interfere with the execution or the assessment of the exercise.

Keywords: sleep quality aerobic and resisted exercises cabg
hyponatremia in covid-19 patients

Conditions: Hyponatremia; Covid19; Corona Virus Infection

Summary: systemic inflammation has been associated with severe covid-19. hyponatremia can result from inflammation due to non-osmotic stimuli for vasopressin production. in this prospective cohort study we analized data from patients with covid-19 and the asociation with hyponatremia and clinical outcomes.


Eligibility criteria:
inclusion criteria: * patients with sars-cov-2 infection confirmed by pcr of nasopharyngeal swabs. exclusion criteria: -

Keywords: inflammation covid corona
best rest: rest time before blood pressure measurement trial

Conditions: Hypertension; Blood Pressure; Cardiovascular Diseases; Cardiovascular Risk Factor

Summary: the objectives of this study are to: 1. determine the impact of wait time before initiating bp measurement on bp variability 2. determine the difference in bp variability between measurements by amount of initial rest. the investigators also aim to: 1. to determine the total time required to obtain a bp measurement.

hypertension guidelines recommend a minimum of five minute rest time prior to blood pressure (bp) measurements obtained for screening, diagnosis and management of hypertension. this recommended wait time is often not adhered to and is cited as a barrier to regular screening due to length of time, clinic workflow and provider burden. it is unclear if bps obtained at different rest intervals would provide clinically similar measurements. this study therefore aims to determine if bps obtained immediately or after 2 minutes are rest are non-inferior to the bps obtained after the guideline recommended 5 minutes of rest. it also aims to determine the time required to measure bp from start to finish, to allow for easier identification of other potential barriers to regular bp screening practices in busy clinical settings.

Eligibility criteria:
inclusion criteria: * age 18-80 years exclusion criteria: * presence of the following on both arms: rashes, gauze dressings, casts, edema, paralysis, tubes, open sores or wounds, withered arms, a-v shunts, or if blood has been drawn from arm within last week. * being mentally impaired, pregnant. * arm circumference exceeding 50 cm.
usefulness of markers to predict recurrence of atrial fibrillation after radiofrequency catheter ablation

Conditions: Atrial Fibrillation

Summary: catheter ablation using radiofrequency is a new therapeutic tool to treat atrial fibrillation with a higher success rate than medical therapy (80% versus less than 50% respectively). because of the length of the intervention and of the risk of complications of the procedure, it would be important to determine success rate before the intervention. the information gained from this study will in all probability improve our estimation of the chances of a successful intervention and may enable us to take necessary therapeutic measures in case of an elevated risk of recurrence. multiple studies suggest that the 2 markers in this study could provide information of this nature, however, their utility in the radiofrequency catheter ablation treatment of atrial fibrillation has never been demonstrated.

catheter ablation of atrial fibrillation is a recent therapeutic tool to treat atrial fibrillation. the success rate of eliminating atrial fibrillation by radiofrequency catheter ablation is 80 %, after one or sometimes two procedures, against 20-50 % with drug treatment. this intervention may be complicated by : hematoma at the puncture site - 1 % incidence; thromboembolic events \< 1 % incidence; cardiac perforation with tamponade \< 1 %, pulmonary vein stenosis 2 % incidence. the aim of this study is to evaluate blood tests of biological products (nt-probnp and crp) as markers of prognosis and success after radiofrequency catheter ablation for atrial fibrillation. previous studies demonstrated the prognostic value of nt-probnp and crp in the recurrence of atrial fibrillation after electrical cardioversion. however the prognostic value of these biomarkers was never demonstrated in the setting of radiofrequency catheter ablation of atrial fibrillation. this is an observation study including 180 patients with the indication of catheter ablation for atrial fibrillation. confounding factors of increased nt-probnp will be assessed with echocardiographic imaging.

Eligibility criteria:
inclusion criteria: * atrial fibrillation * indication for catheter ablation of atrial fibrillation exclusion criteria: * significant valvulopathy * previous catheter ablation for atrial fibrillation or atrial flutter * left ventricular ejection fraction \< 30% * severe heart failure (nyha iv) * severe enlargement of left atrium (\> 55mm)

Keywords: arrythmia atrial fibrillation proteins
4-week lead-in with nitazoxanide followed by 36 weeks nitazoxanide and peginterferon alfa-2a in chronic hepatitis c

Conditions: Chronic Hepatitis C

Summary: the purpose of this study is to determine if taking nitazoxanide alone for 4 weeks followed by 36 weeks of nitazoxanide plus peginterferon is superior to peginterferon plus ribavirin (standard of care) for 48 weeks.


Eligibility criteria:
inclusion criteria: * chronic hepatitis c exclusion criteria: * previously failed to respond to at least 12 weeks of peginterferon plus ribavirin combination therapy. * unable to take oral medication. * females who are either pregnant, breast-feeding or not using birth control. * males whose female partners are pregnant or plan to become pregnant. * other causes of liver disease (for example, autoimmune hepatitis, decompensated liver disease). * patients with hiv, hav, hbv or hdv. * patients with a history of alcoholism or with an alcohol consumption of more than 40 grams per day. * patients with hemoglobinopathies (for example, thalassemia major, sickle-cell anemia). * history of hypersensitivity or intolerance to nitazoxanide or peginterferon.

Keywords: chronic hepatitis c viral hepatitis
use of in-line filtration in critically ill children

Conditions: Critical Illness

Summary: the purpose of this study is to determine whether the use of in-line filtration shows any effect on the outcome of sepsis, systemic inflammatory response syndrome (sirs), thrombosis, or organ failure in critically ill children admitted to the pediatric intensive care unit (picu).

scientific background: particulate contamination of infusion solutions and their systemic administration during infusion therapy has been linked to various clinical problems. organ failure and multi-organ failure (mov): it is well established that the pathophysiology of mov involves deteriorations of the microcirculation and integrity of endothelial cells. as a consequence of this an imbalance between pro- and anticoagulatory factors may develop and microthrombi may form. mediators like tissue factor (tf) and platelet activating factor (paf) have been linked to the formation of microthrombi. particles have been discussed as a causative agent for this syndrome by various authors. their effect on morbidity and mortality of patients has however not yet been established. particles may have additional harmful effects: * direct thrombogenesis by the particle material * damaging endothelial cells in the capillary network * embolisation of the pulmonary vasculature * acting as a cristallisation focus for the development of granuloma * promoting the formation of giant cells various authors have shown that the use of end line infusion filters significantly reduces the rate of thrombophlebitis. a recently published study by van lingen et al. (2004) also showed that the use of end line infusion filters significantly reduced the rate of overall complications in neonates. study hypothesis: the use of end line positively charged 0.2 µm and uncharged 1.2 µm infusion filters will prevent particles, microorganisms and their endotoxins from the infusate to enter the patient's circulation in the study group and will reduce significantly the complication rate of these patients. the following clinical diagnoses are defined as "complications". they are main contributors to morbidity and mortality in intensive care wards: * catheter related thrombosis of the central veins * sepsis with proven infectious organisms * septic syndrome without proven infectious organisms * failure of one of the following organs/systems 1. lung 2. kidney 3. liver 4. circulation

Eligibility criteria:
inclusion criteria: * children admitted to pediatric intensive care unit (picu) exclusion criteria: * suspected death within 48 hours * duration of picu stay less than 6 hours * patients recruited for simulect or sintra study

Keywords: pediatric intensive care critically ill children in-line filtration prospective randomized study complications sepsis sirs thrombosis organ failure
efficacy of treatment for panic disorder

Conditions: Panic Disorder

Summary: the purpose of these questionnaires is to give us an overview of how panic has affected your life and perhaps also to give us some clues about things that may have set you up to experience panic.

for us to evaluate the efficacy of our treatment programs, we are interested in your responses before and after treatment. we use two methods to evaluate the efficacy of our treatments: questionnaires and interviews with a member of the anxiety disorders clinic. as part of standard clinic procedure, each person in the program completes an in-person interview with a staff member who will determine your suitability for treatment. if you have received this questionnaire packet, it is likely that your concerns will be appropriately addressed in the anxiety disorders clinic. the purpose of the questionnaire packet is to assess the severity of your panic disorder; its impact on your functioning, and factors that may contribute to the onset or maintenance of your panic (e.g., depression, anxiety sensitivity). we will ask you to complete this questionnaire again when you have completed your treatment along with a brief telephone interview with a staff member of the anxiety disorders clinic.

Eligibility criteria:
inclusion criteria: * patients referred to the anxiety disorders clinic who receive a primary diagnosis of panic disorder, and are accepted for treatment at the clinic. exclusion criteria: * individuals who either have not sought treatment for anxiety at the anxiety disorders clinic or patients who did not receive a primary diagnosis of panic disorder.

Keywords: panic disorder anxiety treatment efficacy
insulin resistance, lipid profile, crp, il-18 and carotid intima-media thickness (cimt) diameter in obese adolescents

Conditions: Obesity, Adolescent

Summary: carotid intima-media thickness (cimt) is a marker for detecting endothelium dysfunction, and has become a non-invasive method that is very useful in detecting and evaluating subclinical atherosclerosis in obese children and adolescents. this method is very useful in visually detecting and monitoring changes in the intima and its medial thickness, and can also evaluate changes within the arterial wall in the absence of localized plaque. previous research that was conducted found an increase in cimt diameter in 44 of 59 obese adolescents. obesity has a risk of increasing the diameter of cimt which carries the risk of atherosclerosis. obesity accompanied by insulin resistance, and metabolic syndrome has a greater risk of atherosclerosis. currently, the prevalence of obesity in adolescents is increasing. interleukin 18 is a group of interleukin 1 whose levels increase in chronic inflammatory processes such as obesity, metabolic syndrome, and type 2 diabetes mellitus. il-18 levels increase in obesity with increased cimt. assessment of cardiovascular risk in obese adolescents is still a challenge for health practitioners, to prevent cardiovascular complications in obese adolescents which can cause sudden death at a young age. it is necessary to assess changes in the cardiovascular system that can be identified early by knowing the cimt diameter. however, there is no definite reference value so the cimt can be used as a reference for the occurrence of subclinical atherosclerosis in obese adolescents. in the previous study, cimt was not examined in non-obese adolescents, so the cut-off for cimt in non-obese was not known. therefore, we have the opportunity to research to determine the thickness of cimt and determine the cut-off value of cimt which is at risk of experiencing early atherosclerosis in the obese adolescent population.

this research is a cross-sectional study with an analytical observational to examine carotid intima-media thickness (cimt) in normal adolescents compared to obese adolescents. the research population was obese adolescents aged 13-18 years who study in junior and senior high school in surabaya and sidoarjo. the samples were research subjects, namely obese teenagers who met the inclusion criteria and exclusion criteria. the selection of research samples was carried out randomly. the number of research samples was based on previous research with adolescent subjects, obtaining a minimum sample size of 50.

Eligibility criteria:
inclusion criteria: * adolescents (obese and normal) * aged 13-18 years old * not smoking * not consumed alcohol and drugs exclusion criteria: * suffering from infections, inflammation, autoimmune diseases, cancer, chronic diseases, and endocrine disorders * consuming steroids or hormone therapy
lung function in bariatric surgery candidates

Conditions: Lung Function Decreased; Obesity

Summary: this study aims to retrospectively investigate the impact of body mass index on lung function metrics, e.g. fev1%, fvc%, fev1/fvc%.


Eligibility criteria:
inclusion criteria: * subjects with obesity (bmi ≥ 27.5 kg/m2 according to chinese guidelines, guidelines from the american society for metabolic and bariatric surgery and international federation for the surgery of obesity and metabolic disorders); * age \> 16 years; * complete preoperative pulmonary function tests exclusion criteria: * patients with a history of lung surgery and/or respiratory diseases (e.g. asthma, pulmonary emphysema, and interstitial pulmonary fibrosis).