Kornimate/medical-research-clean huggingface dataset:
study to assess the efficacy of an extended injection interval schedule of lanreotide autogel in acromegalic subjects

Conditions: Acromegaly

Summary: the purpose of the study is to assess the efficacy of an extended injection interval schedule of lanreotide autogel 120 mg in acromegalic subjects who are biochemically controlled on long term treatment with octreotide lar 10 or 20 mg


Eligibility criteria:
inclusion criteria: * the subject has given written informed consent prior to any study-related procedures * the subject is male or female and is over 18 years of age * the subject must have had documentation supporting the diagnosis of acromegaly, based on elevated igf-1 and/or gh levels * the subject has been receiving octreotide lar (10 or 20 mg) treatment for at least six months and is biochemically controlled. control is defined as normal (age and sex adjusted) igf 1 levels for two consecutive measurements (at least two months apart) preceding study entry * if the subject is receiving dopamine agonist therapy, treatment should be stable for at least four months, and no change in their dopamine-agonist medication is expected during the entire study period exclusion criteria: * the subject has received radiation therapy to the pituitary gland before study entry * the subject has a history of hypersensitivity to lanreotide or drugs with a similar chemical structure * the subject has received a growth hormone receptor antagonist (pegvisomant) therapy within three months before study entry * the subject has undergone treatment with any other investigational drug in the 30 days before study entry or is scheduled to receive an investigational drug, other than lanreotide 120 mg, during the course of the study * the subject has received any unlicensed drug within the 30 days prior to the baseline visit or is scheduled to receive an unlicensed drug during the course of the study
carto® 3 system and real time intracardiac ultrasound

Conditions: Atrial Fibrillation; Paroxysmal AF

Summary: this is a prospective, multicenter, non-randomized observational study of subjects 18 years and older undergoing rf ablation with drug refractory recurrent symptomatic paroxysmal atrial fibrillation (af).

this study is purposed to measure "real world" acute procedural outcomes (procedural efficiency and acute safety) associated with use of the carto® 3 system and real time intracardiac ultrasound in a clinical setting in subjects with drug refractory recurrent symptomatic paroxysmal af.

Eligibility criteria:
inclusion criteria: * drug refractory, recurrent symptomatic paroxysmal af * age 18 years or older * patients able and willing to provide written informed consent to participate in the study and comply with study requirements exclusion criteria: * atrial fibrillation secondary to electrolyte imbalance, thyroid disease, or reversible or non-cardiac cause * previous ablation for atrial fibrillation * af episodes that last longer than 30 days * uncontrolled heart failure, or nyha class iii or iv heart failure * documented intra-atrial thrombus or other abnormality on pre-ablation imaging * contraindication to anticoagulation * stroke, cardiac surgery, unstable angina, myocardial infarction or percutaneous coronary intervention within the past 3 months * awaiting cardiac transplantation * heart disease for which corrective surgery is anticipated within 6 months * enrollment in other investigational drug or device study * subjects unwilling to comply with protocol or follow-up requirements * patients who are pregnant

Keywords: symptomatic paroxysmal atrial fibrillation observational acute procedural outcomes ablation
greek childhood obesity (greco) study

Conditions: Overweight; Obesity; Dietary Habits; Physical Activity; Blood Pressure

Summary: the purpose of the greco study were to: a) to provide national data on overweight and obesity prevalence in a representative sample of primary schoolchildren aged 10-12 years old, b) to identify those socio-economic, demographic factors, as well as dietary and physical activity habits and familial characteristics that are associated with childhood and preadolescent overweight and obesity, c) to identify lifestyle and dietary patterns that are associated with elevated blood pressure levels and dietary sodium intake.


Eligibility criteria:
inclusion criteria: * within the age range * 5th and 6th grade public schools children * consent form provided by the parents exclusion criteria: * not providing signed parental consent forms * outside the required age range

Keywords: overweight obesity dietary intake physical activity levels blood pressure levels family perceptions
effect of varying proportions of low and high energy dense foods over 5 days in preschool children

Conditions: Feeding Behavior

Summary: in this study, the investigators will vary the proportions of high- and low-energy-dense foods served to preschool children at all meals and snacks during three 5-day periods. in the three experimental conditions, the same foods will be served; only the amounts and proportions of foods will be varied. in the baseline condition, typical proportions of age-appropriate foods will be served. in the addition condition, the portion sizes of low-energy-dense foods will be increased, and in the substitution condition, the portions of low-energy-dense foods will be increased by replacing an equivalent amount of foods higher in energy density. the primary aim is to determine the effect on children's energy intake of varying the proportion of low- and high-energy-dense foods served, either by addition or substitution, over 5 days. it is hypothesized that children will consume less energy when they are served meals in which low-energy-dense foods are substituted for foods higher in energy density over 5 days and that children will consume more energy when served meals to which low-energy-dense foods are added. additionally, we will test the hypothesis that daily energy intake in the three conditions will begin to converge across the 5-day period.


Eligibility criteria:
inclusion criteria: * attending one of the designated daycare centers exclusion criteria: * food allergies * food restrictions * health issues that preclude participation * not available for duration of the study
diet and activity promotion among older working adults

Conditions: Cardiovascular Disease; Diabetes; Obesity; Aging

Summary: the trial will test whether the alive email-delivered health behavior program can improve subjects' physical activity, fruits and vegetables and saturated/trans fats and added sugars.


Eligibility criteria:
inclusion criteria: * aged 50+ * currently employed * access to email/web exclusion criteria: * angina

Keywords: behavior change physical activity nutrition fruits and vegetables saturated fat trans fat added sugars email web obesity aging
fate at long-term of mild to moderate bicuspid aortic valve disease left untreated at the time of supracoronary ascending aorta replacement

Conditions: Bicuspid Aortic Valve; Ascending Aorta Aneurysm

Summary: aortic valve bicuspid disease is the most common congenital heart disease. it affects 0.5-2% of the population and is associated with an increased risk of developing aortic or ascending aortic valve complications. there is no agreement regarding the opportunity for a "prophylactic" simultaneous aortic valve replacement in the case of mild or moderate aortic valve disease in the bicuspid valve, in patients with an indication for replacement of the ascending aorta due to an aneurysm involving its supra-coronary tract. the aim of this study is to evaluate the long-term evolution of mild and moderate aortic valve disease in untreated bicuspid valve during supracoronary ascending aortic replacement surgery at our institution.


Eligibility criteria:
inclusion criteria: * adult patients; * bicuspid aortic valve; * presence of ascending aortic aneurysm in the supra-coronary tract treated with replacement using a prosthetic tube between 2002 and january 2020; * untreated aortic valve disease of no more than moderate degree (\<2+) at the time of ascending aorta surgery. exclusion criteria: * emergency/urgency procedures; * presence of aneurysm extending to the aortic arch or aortic root, with indication for aortic root or aortic arch surgery; * tricuspid aortic valve tricuspid; * absence of aortic valve disease; * presence of moderate-severe or severe aortic valve disease, with indication to a concomitant aortic valve replacement.
impact of physical activities on balance in patient with strabismic amblyopia

Conditions: Balance Control

Summary: the aim of this study is to determine the effect of physical activities on balance in patient with amblyopia after strabismus surgery. patients with strabismus have more difficulty in maintaining postural control in the presence of misleading signals. through this study the patients will apply physical therapy sessions to improve balance for strabismic amblyopic patient post-surgery.

* patients will be informed about measurement and treatment procedure, also about the effect of physical activity on improving balance post strabismus surgery. * patients will be asked to follow physician instructions. * patients will be asked to avoid participation in any rehabilitation program prior to the study which may affect the result of the study. * measurement procedures will be applied for each patient. * the therapeutic group will receive 2 sessions per week for 12 weeks. the duration of each session is 45 min. * they will start the treatment program after 2 months of the surgery.

Eligibility criteria:
inclusion criteria: * patients received strabismus operation. * patients are suffering from balance problem due to strabismus * patients are suffering from strabismus amblyopia * they will be selected from outpatient clinic of research institute of ophthalmology. * patients will begin the training program after 2 months of operation. * patient with intermittent exotropia exclusion criteria: * - patients with a diagnosis of vestibular, neurological and psychiatric diseases * moderate and severe amblyopia, * any disease that can cause imbalance syndrome or limitation of movement * a history of falling without a cause in the last 6 months and * using drugs affecting the central nervous system * patient who didn't complete the physiotherapy training program for 3 months. * muscular disorders that will impair performance during training. * any organic lesion in the eye. * malignant conditions. * children who can't understand the therapist's instructions and orders * amblyopia which is not related to strabismus condition

Keywords: balance stabismus amblyopia physical therapy exercises
to compare anterior knee pain between non severe and severe patellofemoral arthritis after oxford uka

Conditions: Osteoarthritis

Summary: the aims of this study is to compare the results between patients without severe patellofemoral arthritis and patients with severe patellofemoral arthritis after mobile bearing uka. the investigators prospective compute the results including anterior knee pain, knee society score, pain score, functional score, range of motion, operative time, blood loss, and component alignment.

the patients were performed surgery. the oxford uka was applied for all patient.

Eligibility criteria:
inclusion criteria: * anteromedial osteoarthritis knee, * older than 40 years old, * range of motion \> 90 degrees, * varus deformity \< 25degrees, * flexion contracture\< 20degrees, * intact anterior cruciate ligament exclusion criteria: * younger than 40, * osteonecrosis of knee, * rheumatoid, * posttraumatic arthritis, * absent of anterior cruciate ligament

Keywords: oxford uka anterior knee pain lateral facet of patella
trial of pde4 inhibition with roflumilast for the management of plaque psoriasis

Conditions: Chronic Plaque Psoriasis

Summary: this is a double-blind, parallel group, vehicle-controlled study to assess the safety and efficacy of roflumilast (arq-151) 0.3% cream vs vehicle (placebo) cream for treatment of chronic plaque psoriasis (cpp) in adult participants with 2 to 20% body surface area (bsa) of cpp.


Eligibility criteria:
inclusion criteria: * participants legally competent to sign and give informed consent and if appropriate assent as required by local laws * males and females ages 2 years and older (inclusive) * clinical diagnosis of psoriasis vulgaris of at least 6 months duration (3 months for children) as determined by the investigator * females of childbearing potential (focbp) must have a negative pregnancy test at screening (visit 1) and baseline (visit 2). in addition, sexually active focbp must agree to use at least one form of highly effective contraception throughout the trial. * in good health as judged by the investigator, based on medical history, physical examination, serum chemistry labs, hematology values, and urinalysis. * subjects considered reliable and capable of adhering to the protocol and visit schedule, according to the judgment of the investigator. exclusion criteria: * planned excessive exposure of treated area(s) to either natural or artificial sunlight, tanning bed or other led. * females who are pregnant, wishing to become pregnant during the study, or are breast-feeding. * previous treatment with arq-151 or its active ingredient * subjects with any serious medical condition or laboratory abnormality that would prevent study participation or place the subject at significant risk, as determined by the investigator. * subjects with a history of chronic alcohol or drug abuse within 6 months of initiation of investigational product * subjects who are unable to communicate, read or understand the local language, or who display another condition, which in the investigator's opinion, makes them unsuitable for clinical study participation
effect of optic edge design in a silicone intraocular lens on posterior capsule opacification

Conditions: Cataract; Pseudophakia

Summary: purpose: to compare the posterior capsule opacification (pco) inhibiting effect of the sharp posterior optic edge design of the clariflex silicone intraocular lens (iol) with that of the double-round edge design of the si40 (phacoflex) silicone iol over a period of 3 years. setting: department of ophthalmology, medical university of vienna, vienna, austria. methods: fifty-two patients with bilateral age-related cataract (104 eyes) were included in this randomized, prospective, bilateral, patient- and examiner-masked clinical trial with intra-individual comparison. each study patient had cataract surgery in both eyes and received an si40 iol (anterior and posterior round optic edges) in one eye and a clariflex iol with optiedge (round anterior and sharp posterior optic edge) in the other eye. follow-up examinations were at one week, one month, six months, one, two, and three years. digital retroillumination images were taken of each eye. the amount of pco was assessed subjectively at the slit-lamp and objectively using automated image analysis software (aqua) one, two, and three years after surgery.


Eligibility criteria:
inclusion criteria: * bilateral, age related cataract exclusion criteria: * history of other ocular disease or intraocular surgery * diabetes requiring medical control

Keywords: posterior capsule opacification pco after cataract intraocular lens optic edge design sharp optic edge
efficacy study of glucagonlike peptide-1 to treat reperfusion injury

Conditions: Acute Myocardial Infarction

Summary: the investigators planned to research the cardioprotective effects of intravenous liraglutide on reperfusion injury.

acute myocardial infarction is a major cause of mortality and morbidity. primary percutaneous coronary intervention (ppci) is currently the most effective treatment strategy in acute myocardial infarction. however, a sizable number of patients fail to restore optimal myocardial reperfusion, mostly because of the 'no-reflow' phenomenon. glucagon-like peptide-1 (glp-1) is an incretin hormone that regulates plasma glucose, and recently glp-1 analogues have been introduced for the treatment of type-2 diabetes. in experimental studies, glp-1 or its analogues protect against reperfusion injury-induced cell death. exenatide reduces reperfusion injury in patients with st-segment elevation myocardial infarction. liraglutide(glp-1) is safe and effective to reduce weight,serum lipid levels and blood pressure. liraglutide can reduce cardiac rupture (12 of 60 versus 46 of 60; p=0.0001) and infarct size (21±2% versus 29±3%, p=0.02) and improved cardiac output (12.4±0.6 versus 9.7±0.6 ml/min; p=0.002) in normal and diabetic mice. the investigators planned to research the cardioprotective effects of intravenous liraglutide administered prior to reperfusion and continued after restoration of coronary blood flow in patients with stemi undergoing ppci.

Eligibility criteria:
inclusion criteria: patients were eligible if they were 18 years or older and presented within 12 h from the onset of symptoms and signs of st-segment elevation myocardial infarction to the catheterization laboratory. exclusion criteria: the patients were not considered for enrolment if they presented with unconsciousness, cardiogenic shock, hypoglycaemia, diabetic ketoacidosis, previous myocardial infarction, stent thrombosis, known renal insufficiency, or previous coronary artery bypass operation.

Keywords: reperfusion injury liraglutide
recovery of walking in persons with complete spinal cord injury

Conditions: Spinal Cord Injuries

Summary: we documented the impact of 1 year of underwater treadmill training and supplemental overground walk training in five adults with chronic motor-complete sci (csci) who had not undergone programmed epidural spinal cord stimulation (escs).

regular exposure to self-initiated treadmill walking in water, a unique sensorimotor exercise setting that makes stepping movements easier to perform, may capitalize on the adaptability of the neuromuscular system and enhance locomotor function in persons with csci who have not undergone escs. in our study, a combined aquatics- and land-based approach to gait training was employed over a 12-month period that featured underwater treadmill training and supplemental overground walk training.

Eligibility criteria:
inclusion criteria * at least 21 years of age * presence of traumatic or non-traumatic spinal cord injury for at least 1 year * medical diagnosis of paraplegia (t1 or below) exclusion criteria * presence of complex comorbidities that could limit involvement in training activities * surgical implantation or removal of a medical device six months prior to training * skin breakdown * use of electrical implants to promote ambulation

Keywords: spinal cord injury exercise walking aquatics
effect of modified endotracheal intubation protocol combined with early oral intake on postoperative recovery quality in thyroid and parathyroid surgery

Conditions: Thyroid Tumor

Summary: the purpose of this study is to assess the effect of modified endotracheal intubation procedure combined with early oral intake on postoperative recovery quality of patients, so as to further optimize the eras（enhanced recovery after surgery） program for thyroid or parathyroid surgery.

after being informed about the study and potential risk, all patients giving written informed consent will undergo a screening-period to determine eligibility for study entry. before operation, patients will be randomly assigned to conventional intubation process group or modified intubation process group before the operation. after the operation, patients will enter the pacu（post-anaesthesia care unit） for further observation. when the anesthesiologists and surgeons agree that patients have no early oral drinking high-risk factors, patients will be randomly assigned to early resumption of oral intake group or late resumption of oral intake group for further observation and evaluation.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * american society of anesthesiologists (asa) physical status classification i-ii * body mass index 18.5-29.9kg/m2 * first operation on operation day exclusion criteria: * patients or family members cannot understand the conditions and objectives of this study * preoperative patients with acute pharyngitis, hoarseness, cough, dysphagia, and high risk of aspiration * the surgeons or anesthesiologists point out that the patient is not suitable for early postoperative drinking (such as considering the injury of recurrent laryngeal nerve or lymphatic vessels during the operation) * patients who cannot be intubated under visual laryngoscope(such as difficult airway, loose incisors and so on) * exclusion criteria of quality of recovery-15\* (\*quality of recovery-15 exclusion criteria: 1. unable to understand words and language; 2. difficult to cooperate due to mental disorders; 3. history of alcohol or drug abuse; 4. any serious pre-existing medical condition that can limit the objective evaluation after surgery; 5. any life-threatening complications; 6. emergency surgery)

Keywords: thyroidectomy enhanced recovery after surgery quality of recovery-15 parathyroidectomy
assessment of the health improvement of obese patients after fecal microbiota transplantation (fmt)

Conditions: Obesity; Familial

Summary: search for mechanisms of the effect of fecal microbiota transplantation on patients with obesity

1. to select recipients of fecal samples according to eligibility criteria; 2. to perform fecal microbiota transplantation for patients with obesity; 3. to analyze the efficacy of fecal microbiota transplantation for patients with obesity within six months after therapy.

Eligibility criteria:
inclusion criteria: * age of patients - from 18 to 75 years, both sexes; * patients with obesity (body mass index ≥40 * patient's informed consent to perform fecal microbiota transplantation exclusion criteria: * presence of a concomitant chronic infectious disease or malignancy * patients with a proven allergy to foods not excluded from the donor's diet * absence of the patient for one or more intermediate stages of the examination. * informed refusal to continue therapy
study of giant viruses of amoebas infections in children suffering from gastroenteritis

Conditions: Gastroenteritis

Summary: the discovery in 2003 by isolation of amoebas mimivirus, the world's largest virus at the research unit on tropical and emerging diseases in marseille revealed fascinating information about the definition and evolution of viruses. its genome encodes about 1,000 proteins. three other viruses were then isolated from amoebas in this unit:two other giant viruses, mamavirus marseillevirus then, and the first virus a virus, named virophage, which led to highlight the role of amoeba (acanthamoeba spp. ) such as spawning giant viruses and compounds of bacterial origin or cellular proteins this project focuses on the detection and analysis of new viral agents (viruses and virophages giant amoeba environmental) and their involvement in human pathology. the objectives of this study are observational: detect and document the presence of giant viruses and virophages of amoebae in the faeces of children presenting to the pediatric emergency reception service of the north hospital in ap -hm with or without clinical evidence of gastroenteritis.


Eligibility criteria:
inclusion criteria: * patient admitted in the pediatric emergency service of northern hospital, marseille, france * patient aged ≤ 15.3 years, male or female; * patient for whom a microbiological exam should be performed during the clinical management, with or without a clinical diagnosis of gastroenteritis (ie including diarrhea which will be defined by the issuance of at least three molded or watery stools per day for more than 24 hours) at the time of the collection of stool; * patient for whom informed consent was read, understood, signed by a parent or legal representative. exclusion criteria * patient aged \> 15.3 years; * patient for whom informed consent is not signed by a parent or legal representative.

Keywords: giant virus amoeba