Kornimate/medical-research-clean huggingface dataset:
evaluation of body-worn multimodal hand hygiene system. impact on health-care associated infections

Conditions: Nosocomial Infection

Summary: evaluate the efficacy of a multimodal hand hygiene system in the intensive care unit environment and evaluate any impact on health care associated infections.

deploy and utilize a novel body worn hand hygiene system that incorporates provider and group specific feedback allowing hand hygiene to occur directly within the patient environment. we hypothesize that by improving provider hand hygiene we will reduce health-care associated infection rates.

Eligibility criteria:
inclusion criteria: * all icu patients exclusion criteria: * patient is not in an icu at our institution

Keywords: alcohol rub hand hygiene provider feedback health care associated infections
comparison between tramadol hcl and other analgesics in the treatment of renal colic

Conditions: Renal Calculus

Summary: the purpose of this study is to determine whether tramadol hcl is as effective as voltaren a non-steroidal antiinflammatory drug, and dipyrone in amelioration of the pain caused by acute renal colic.

renal stones is a common condition affecting up to 1% of the american population. the main symptom is renal colic. acute treatment is based on the administration of analgesics mainly those belonging to non-steroidal antiinflammatory drugs (nsaids). tramadol is an analgesic of the opioid class of analgesics (i.e morphine) and it is considered to cause less side effects with more or less the same analgesic potency. in the present study the analgesic effect of intramuscular tramadol will be compared with voltaren (nsaid)in patients attending the emergency department (ed) for acute renal colic (stage i). most of these patients will not pass their stone during their visit to the ed and they are prone to develop another attack of renal colic.in the second phase of the study (stage ii)patients who improved, and are ready to go home, will be enrolled to get dipyrone or tramadol orally for the prevention of further pain.

Eligibility criteria:
inclusion criteria: * patients with clinical diagnosis of acute renal colic (stage i) * patients with diagnosed renal colic who might need prevention of pain and are able to swallow medicines (stage ii) exclusion criteria: * patients with known hypersensitivity to the study drugs * pregnancy or lactation * known renal failure or hepatic disease * concommitant drug use which could adversely affect patient's outcome (oral anticoagulant, mao inhibitors)

Keywords: renal colic calculi treatment
fat quality and postprandial inflammation

Conditions: Inflammatory Response; Inflammation

Summary: this aim of this randomized controlled postprandial study is to compare the effects of four different far sources (butter, coconut, corn oil and flax seed oil) on postprandial inflammation and metabolic response. the main questions it aims to answer are: 1. what is the impact of different dietary sources of saturated and polyunsaturated fatty acids on postprandial inflammation? 2. is the impact of different dietary sources of saturated and polyunsaturated fatty acids on postprandial inflammation mediated by glucose or blood lipids? 3. can postprandial inflammatory or metabolic response be predicted by individual factors at baseline? participants will consume four meals, identical except for the fat source, in random order and sampled for blood and urine for up to 6 hours.

a randomized crossover single meal study will be conducted, comparing four isocaloric meals. the study will be carried out at two sites; one study center is located in gothenburg, sweden (department of internal medicine and clinical nutrition at the university of gothenburg) and one study center in oslo, norway (department of nutrition, university of oslo). a total of 20 healthy adults will be recruited and consume four meals, identical except for the fat source, in random order and sampled for blood and urine for up to 6 hours after. each of the four meals will be separated by a 1 month washout. subjects will be asked to abstain from rigorous physical activity, alcohol and high-fat foods the day prior to their test meal days. four isocaloric high-fat meals with different fatty acid profiles will be compared: 1. butter 2. coconut oil 3. corn oil 4. flax seed oil at test meal days, study outcomes will be assessed at baseline (0h, fasting, pre meal), 30 min, 1h, 2h, 4h and at 6h (endpoint). at these timepoints, blood pressure will be measured and blood glucose sampled through capillary blood. at baseline, 2h, 4h and 6h, blood will be drawn by venipuncture. urine will be collected when the participants need to void. blood will be collected and handled according to a standardized protocol to prevent any degradation, before stored in -80°c until analysis. at baseline and endpoint, peripheral blood mononuclear cells from blood samples will be isolated using cell preparation tubes and stored at -80 °c until rna isolation. lipids, lipoprotein profile and inflammation markers (e.g. cytokines, chemokines, endothelial factors) will be analyzed in samples from 0, 2, 4 and 6 hours. differences between meals in the outcomes will be compared using area under the curve and mixed models effect.

Eligibility criteria:
inclusion criteria: * bmi \>18.5 * willingness to eat study meals exclusion criteria: * diabetes * cardiovascular disease * cancer * dyslipidemia * anemia (hb \<100) * habitual intake of anti-inflammatory drugs * recent weight change (\>±5%) * pregnancy, lactation * current smoking

Keywords: inflammation diet fat
artificial intelligence models for precision prediction and treatment of prostate cancer

Conditions: Prostate Cancer; Prostate Intraductal Carcinoma; Prostate Cancer Aggressiveness; Prostate Cancer Stage; Pathology

Summary: the aim of this clinical trial is whether artificial intelligence models can be used for accurate clinical preoperative diagnosis and postoperative diagnosis of pathological findings, and will also measure the accuracy of the predictions made by the artificial intelligence models.the main target questions addressed by the model building are: 1. whether the ai model can learn from preoperative mri and postoperative whole slide images so as to accurately predict information such as benignness or malignancy, aggressiveness, grading, subtypes, genes, etc. for participants suspected of having prostate cancer preoperatively/puncturally. 2. whether the ai model is capable of learning postoperative macropathology slides to enable outcome diagnosis of surgical pathology slides in new participants. participants will: 1. complete an mri examination and have their mri images analysed by the established ai model to make an accurate diagnosis of them. 2. based on the diagnosis, if prostate cancer is predicted, they will undergo radical prostate cancer surgery and refine their surgical pathology.

based on artificial intelligence technology, the prediction model is built by outlining the quantitative mapping correlation between annotated prostate cancer whole slide images and mri, and clarifying the common features. firstly, the model can accurately diagnose the radical pathology of prostate cancer, which can be exempted from immunohistochemistry to obtain detailed pathological information; secondly, the established ai prediction model can accurately diagnose the benign/malignant, invasiveness, grade and subtype of prostate cancer by predicting the participant's mri images before surgery or puncture, so that a personalised treatment plan can be formulated for the patient before operation or puncture. finally, based on ai technology, the model learns from the mri images and performs 3d reconstruction of the prostate and lesions before surgery/puncture, thus clarifying the exact location of the lesions and guiding puncture or surgical treatment.

Eligibility criteria:
inclusion criteria: * patients with suspected pca (elevated psa or suspicious positive lesions on ultrasound or mri results); exclusion criteria: * previous treatment of the prostate in any form, including surgery, radiotherapy/chemotherapy, endocrine therapy, targeted therapy and immunotherapy; * patients with any item missing from the baseline clinical and pathological information; * patients with a history of other malignancies, serious comorbidities or other health problems; * unable to provide/sign an informed consent form; * patients who, in the judgement of the investigator, are deemed unfit to participate in this clinical trial;

Keywords: articicial intelligence whole slide image mp-mri prostate cancer prediction model
the effect of osa on severity and prognosis of patients with ckd

Conditions: Obstructive Sleep Apnea; Chronic Kidney Diseases

Summary: this study aims to investigate the influence of obstructive sleep apnea hypopnea syndrome (osa) on the severity and prognosis of patients with chronic kidney disease (ckd), and to evaluate the therapeutic effect of continuous positive airway pressure (cpap) intervention in such patients. although the study is designed as an observational cohort study, where patients self-selected whether to receive treatment rather than being assigned, there is still an intervention project, cpap, present in the observational cohort. through a cohort study design, scientific evidences are expected for clinical decision-making and optimize treatment strategies for patients with osa and ckd.


Eligibility criteria:
inclusion criteria: * diagnostic criteria: chronic kidney disease is diagnosed based on clinical manifestations (such as hematuria, proteinuria, abnormal renal function, etc.), in accordance with the internationally recognized diagnostic criteria. obstructive sleep apnea-hypopnea syndrome (osahs) is confirmed through overnight polysomnography (psg) with an apnea-hypopnea index (ahi) of ≥5 events per hour, primarily consisting of obstructive events. * age and gender: participants must be ≥18 years old, with no gender restrictions. * informed consent: participants are required to voluntarily sign a written informed consent form, acknowledging and agreeing to participate in the study, including all its contents and potential risks. exclusion criteria: * other sleep-related breathing disorders: participants with mixed sleep apnea, central sleep apnea, or severe snoring with an ahi index of \<5 events per hour will be excluded to ensure that the study population is limited to patients with osahs. * severe internal medical conditions: patients with severe cardiopulmonary dysfunction, malignancy, severe liver disease, mental disorders, or other severe internal medical conditions that may significantly affect sleep or the progression of kidney disease will be excluded. * recent surgery or medication: individuals who have undergone surgery within the past 3 months that may affect sleep or kidney function, or who are currently using medications that may significantly interfere with sleep or the assessment of kidney disease (such as corticosteroids, immunosuppressants, novel antipsychotics, etc.) will be excluded. * pregnant women. * inability to cooperate with the study: patients who are unable to complete the study procedures (including polysomnography, follow-up, etc.) due to cognitive impairment, language communication difficulties, remote residence, or other reasons will be excluded.
assessment of gerd knowledge level among patients with it in korea

Conditions: Esophagitis, Reflux

Summary: * 1. research topic: how much do patients with gerd know about their own disease in korea? (multicenter survey) * 2. questionnaires for multicenter survey: 1. questionnaire 1 - include items for basic characteristics of participant patients 2. questionnaire 2 - modification of gerd knowledge test which was used in bmc health services research 2008;8:236 (prof. jorgen urnes) * 3. subjects: patients with gerd in secondary or tertiary hospital * 4. participant institutes: gerd club members, the korean society of neurogastroenterology and motility

validation process to produce korean version of gerd knowledge test 1. forward translation of gerd knowledge test of prof. jorgen urnes: through certified translation company 2. expert's review of the forward translated knowledge test : among members of gerd club, 3. pilot survey among nurses and some patients 4. korean version, provisional 5. backward translation: through certified translation company 6. consultation with prof. jorgen urnes about backward translated knowledge test 7. korean version, final 8. print and distribution 9. study start

Eligibility criteria:
inclusion criteria: * patients who were diagnosed as gerd by doctors exclusion criteria: * patients without gerd

Keywords: gastroesophageal reflux disease knowledge
cod liver oil for covid-19 prevention study

Conditions: Covid-19; Respiratory Tract Infections

Summary: a randomized, parallel-group treatment, quadruple masked, two-arm study to assess the effectiveness of cod liver oil compared to placebo in the prevention of covid-19 and airway infections in healthy adults. in this study, the investigators will investigate whether daily cod liver oil can prevent covid-19 infections and reduce the severity of such infections. the investigators will also examine whether cod liver oil prevents other airway infections in healthy adults.

preliminary evidence from literature and an ongoing study in the investigators' lab suggests that cod liver oil may prevent covid-19 and complications of covid-19. in the present study, the investigators will examine whether this is actually the case by randomizing volunteers to take cod liver oil or placebo (corn oil) during the winter months of 2020-2021. the investigators also aim to explore whether cod liver oil can prevent other respiratory tract infections, as well as explore and confirm already known health effects and possible new health effects, in particular rare adverse events associated with cod liver oil use. cod liver oil is a traditional source of vitamin a, d, and e and omega-3 fatty acids and the dose administered in the study will contain 250 ug vitamin a, 10 ug vitamin d, 10 mg vitamin e, and 1,2 g omega-3 fatty acids.

Eligibility criteria:
inclusion criteria: * any person \>18 years with a norwegian personal identity number exclusion criteria: * history of renal failure or dialysis, hypercalcemia, severe liver disease (cirrhosis), sarcoidosis or other granulomatous diseases (wegener) * allergy to fish or corn oil. * pregnancy or planned pregnancy before summer 2021 * vegan diet * age \>75 years old at inclusion based on the norwegian personal identity number * difficulty in swallowing cod liver oil or other oils * previous covid-19 disease * for caucasians only: use of any supplement containing more than trace amounts of vitamin d or omega-3 fatty acids at inclusion (vitamin d levels in non-caucasians living in norway are frequently low even among those self-reporting using dietary supplements). this criterion will be relaxed if too few participants volunteer for the study and only caucasians that use cod liver oil or an equivalent dietary supplement (with omega 3 and vitamin d) more than 5-7 times per week will be excluded.

Keywords: cod liver oil vitamin d n-3 lcpufas sars-cov virus
intermittent fasting in refractory epilepsy

Conditions: Epilepsy

Summary: this is an open trial of intermittent fasting in a group of patients with refractory seizures. patients will continue on the diet for 6 months to assess the impact of the diet on seizure frequency.

a proportion of people with epilepsy continue to have seizures despite all conventional treatment options. the classical ketogenic diet and its variants have been shown to help some of these people. however, these diets require significant medical and dietician supervision,and is frequently not well tolerated. there is a need to develop other diet therapy that is easier to administer and more acceptable to the patient. this trial undertaken in adult overweight uclh outpatients examines the effect of an intermittent fasting diet on seizures. subjects may consume their normal diet for 5 days a week. on 2 days in a week, they consume only 25% of their daily calorie requirement. subjects will continue on the diet for 6 months. intermittent fasting has been shown in animal studies to activate a number of signalling pathways which are thought to reduce seizure thresholds. has intermittent fasting in humans might be expected to reduce seizures.

Eligibility criteria:
inclusion criteria: * experiencing at least 2 seizures per month * .bmi of 25 or over exclusion criteria: * current/previous eating disorder * pregnancy
s. endotoxin, inflammatory mediators and mrs before and after treatment in mhe

Conditions: Hepatic Encephalopathy

Summary: the purpose of this study is to examine s.endotoxins , inflammatory mediators and magnetic resonance spectroscopy (mrs) before and after treatment in patients of cirrhosis and minimal hepatic encephalopathy.

60 patients of cirrhosis with minimal hepatic encephalopathy (mhe) who fulfills the inclusion \& exclusion criteria will be the part of study. study patients will be divided in to two groups ( n=30 in each group). group l patients will receive lactulose therapy while group nl will receive placebo. after 3 months , s.endotoxins , inflammatory mediators and mrs will be repeated in each group.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cirrhosis (age 15 yr -70 yr ) exclusion criteria: * recent history of gastrointestinal bleed in last 6 weeks * active ongoing infection * creatinine \>1.5mg% * electrolyte impairment. (s. sodium \ 5.0meq/l) * h/o use of psychotropic drugs in last 6 weeks * recent alcohol use (\< 6 week ) * h/o tips or shunt surgery. * hepatocellular carcinoma * severe comorbidity as congestive heart failure, pulmonary disease, neurological and psychiatric problems impairing quality of life * poor vision precluding neuropsychological assessment

Keywords: endotoxins he
ozonized gel vs gaseous ozone against s. mutans in deciduos molars caries

Conditions: Dental Caries

Summary: the aim of this study is to verify, through bacteriological analysis, the efficacy of reducing the bacterial load referred to the presence of streptococcus mutans in carious lesions of viable deciduous molars by application of gaseous ozone or ozonized gel. patients who meet the eligibility criteria and for whom the legal guardians have signed the informed consent, will undergo treatment of the carious lesion with gaseous ozone or ozonized gel. after selective removal of dentin, a bacterial sample will be taken from the carious surface with a sterile paper cone at time t0; then ozone will be applied for 30 seconds, the surface will be washed with sterile saline and dried with air, a second sample will be taken at time t2; finally, ozone will be applied for another 30 seconds, the surface will be washed with sterile saline and dried with air, a third sample will be taken at time t2. patients are then randomised into two groups: test group: gaseous ozone (healozone x4) is applied to the carious lesion for 30 seconds and then for another 30 seconds. control group: ozone gel (gelio3) will be applied to the carious lesion for 30 seconds and then for another 30 seconds. changes in the following indices will be assessed at the first visit and when the samples are taken at t0, t1, t2: compliance assessment (flacc scale), sensitivity test (schiff air index), assessment of lesion severity and extent (icdas), assessment of gingival inflammation (gi), assessment of plaque index (pi), assessment of severity of enamel erosion (bewe index).


Eligibility criteria:
inclusion criteria: * patients suffering from carious lesion on viable deciduous molar * patients' compliance exclusion criteria: * patients with early loss of deciduous molars for carious lesions or orthodontic reasons * non-viable deciduous molars * deciduous molars with traumatic lesions
pulmonary functions in relation to gross motor function level

Conditions: Cerebral Palsy

Summary: aim: to investigate the relation between forced expiratory volume at first second and peak expiratory flow with gross motor function level in the children with cerebral palsy. methods and procedures: thirty children with cerebral palsy from both sexes were included in this study. the children ages ranged from 3 to 11 years old.

methods and procedures: thirty children with cerebral palsy from both sexes were included in this study. the children ages ranged from 3 to 11 years old. children were evaluated using spirometer to assess forced expiratory volume at first second and peak expiratory flow and gross motor function classification system to assess the functional level.

Eligibility criteria:
inclusion criteria: * children with cerebral palsy * age was from 3 to 11years old * they were able to sit independently and to follow instructions. * children who can blow air independently. exclusion criteria: * uncontrolled convulsions * any psychiatric disorders
effect of packed red blood cell transfusion on eicosanoid profiles in plasma of intensive care patients

Conditions: Anemia; Critical Illness; Lung Transplantation; Open Aortic Surgery

Summary: the main goal of this pilot study is to assess the time course of eicosanoid profiles in intensive care unit (icu) patients requiring packed red blood cell (prbc) transfusion. moreover we will analyze the change of levels of eicosanoids in patient plasma prior and after a prbc transfusion as well as its correlation with levels of eicosanoids in the transfused prbcs. these data will then be used to determine the estimated effect size necessary for the planning of future larger studies. we hypothesize that transfusion of prbcs will modulate the eicosanoid profile in icu patients. according to the protocol filed with the institutional review board of the medical university of vienna and patient's informed consent, subsequent sub analyses using samples of this study (e.g., determination of extracellular vesicles in prbc samples and patient's plasma) will be performed.


Eligibility criteria:
exclusion criteria: * age \ 99 years * pregnancy * \<12h since last prbc transfusion * intake/administration of acetylsalicylic acid in groups 2 and 3 * intake/administration of cysteinyl leukotriene receptor antagonists (e.g. montelukast) * intake/administration of celecoxib, etoricoxib, parecoxib, ibuprofen, diclofenac, and naproxen in all groups * glucocorticoids given within 24h of transfusion in groups 1 and 3 * treatment with calcineurin inhibitors (e.g. tacrolimus) in groups 1 and 3 * treatment with alemtuzumab in groups 1 and 3 * administration of protamine for heparin reversal in groups 2 and 3