Kornimate/medical-research-clean huggingface dataset:
an exploratory investigation of a novel skincare regimen

Conditions: Wrinkle; Photoaging; Acne; Skin Inflammation

Summary: this trial will assess the effectiveness of the aria trio complete facial system in being able to reduce blemishes, lines, and wrinkles. this skincare system that has three different functions in association with three unique serums. it is hypothesized that this customized skincare system will improve skin quality, reduce wrinkles, and reduce other skin related issues.


Eligibility criteria:
inclusion criteria: * must experience early-stage wrinkles that are not treated by topical or oral prescription drugs/medication * must experience early-stage wrinkles that are not treated by over the counter products (e.g. adapalene/differin) * may experience hyperpigmentation and/or dark spots * in good general health * willing to follow the study protocol skincare routine * willing and able to share feedback and take skin pictures via the technology portal * discontinue use of any alpha-hydroxy acids (ahas) or over the counter exfoliating, polishing, or peeling topical skincare treatments 1 week before and for the duration of the study. exclusion criteria: * anyone with a diagnosed skin condition on their face * use of prescription medication relevant to the skin * undergoing any cosmetic procedures during the study including botox, laser, or chemical peel treatments * use of oral acne treatment (e.g., accutane) * severe chronic conditions, including oncological conditions or psychiatric disorders. * is pregnant, attempting pregnancy, or breastfeeding

Keywords: wrinkles fine lines photoaging sun spots acne enlarged pores skin health
comparison of results of different surgical techniques used in female tubal sterilization

Conditions: Sterilization, Tubal; Visual Analog Pain Scale

Summary: the investigator's aim in this study is to compare the results of tubal ligation surgery, one of the contraceptive methods, between different surgical techniques. 194 patients were included in the study. of these patients, 104 had vaginal approach, 44 had laparotomic and 46 had laparoscopic tube ligation surgery. these surgical techniques are statistically was compared; visual analog pain scale (vas) after surgery, in terms of duration of surgery, length of hospital stay, cost to hospital and amount of blood loss. as a result of the analysis; tubal sterilization technique performed with vaginal colpotomy were found to be more successful than other techniques; visual analog pain scale score, postoperative hospital stay, operation time and cost.

the study compared the peroperative effects and postoperative results of different surgical techniques with three different techniques in patients undergoing tubal sterilization. surgical techniques used: 1. mini laparotomic tubal ligation 2. laparoscopic tubal ligation 3. tubal ligation by posterior colpotomy a total of 194 patients were included in the study. tubal ligation was performed in 44 patients with mini laparotomy, 46 patients with laparoscopy and 104 patients with posterior colpotomy technique. the following parameters were evaluated in the study 1. parity 2. how many of their previous births are vaginal delivery, how many are cesarian section 3. 6th hour visual analog pain scale (vas) score 4. 24th hour visual analog pain scale (vas) score 5. preoperative - postoperative hmg differences 6. surgery time 7. length of hospital stay

Eligibility criteria:
inclusion criteria: * over 31 years old * have completed the fertility request * accepting informed consent exclusion criteria: * being under the age of 32 * having a child desire

Keywords: colpotomy sterilization vas contraception
efficacy of solifenacin or mirabegron with local estrogen versus combination pharmacotherapy for overactive bladder

Conditions: Effect of Drug; Urinary Bladder, Overactive

Summary: to investigates the effects of solifenacin or mirabegron with local estrogen versus combination treatment with solifenacin and mirabegron in women with overactive bladder

women with detrusor overactivity who were refractory to anti-muscarinics or mirabegron were enrolled for prospective study. patients were divided into three groups: combined pharmacotherapy with solifenacin and mirabegron, solifenacin with vaginal estrogen cream and mirabegron with vaginal estrogen cream. incontinence-related symptoms distress and impact on quality of life were evaluated by short form of urinary distress inventory, (udi-6), incontinence impact questionnaire (iiq-7) and overactive bladder symptom score (oabss). objective outcomes include changes from baseline in episodes of daily micturition, urgency, urinary incontinence and nocturia.

Eligibility criteria:
inclusion criteria: * patients with detrusor overactivity which defined as a urodynamic observation characterized by involuntary detrusor contractions during the filling phase. those who were refractory to monotherapy with anti-muscarinics were enrolled for prospective study. exclusion criteria: * postvoid urine retention before treatment * women who had medical illness and contraindication for using solifenacin and mirabegron, such as narrow-angle glaucoma and hypertension * concerns for using estrogen include: women with history of cerebrovascular disease; thromboembolic disorders; gallbladder disease; known or suspected breast carcinoma; estrogen-dependent neoplasm or undiagnosed abnormal genital bleeding.

Keywords: detrusor overactivity combined pharmacotherapy estrogens effectiveness
ibuprofen, acetaminophen and dipyrone to fever control in children

Conditions: Fever

Summary: the purpose of this study was to compare the efficacy and tolerability of acetaminophen, dipyrone and ibuprofen to fever control in children. for the efficacy asses were compared: * the time to start the action; * the action duration; * the difference between the basal temperature and the lower temperature in the study period. for the tolerability asses all adverse events were recorded, as well as your intensity and the relation to the treatment.


Eligibility criteria:
inclusion criteria: * male and female children aged 06 months to 06 years old, weight above 5 kilo and axillary temperature above 37,5 celsius degree. exclusion criteria: * patients with a bad general heath state * patients with neoplasia, pepic ulcer, gastrointestinal bleeding,history of fever convulsion; * intolerant to dypirone, ibuprofen, acetaminophen or any other nonsteroidal antiinflammatory drug; * moderated or severe dehydration; * conscience state alteration; * not capable of ingest oral drugs; * patients being treated with steroids; * patients treated with antiinflammatory, analgesic and antipyretic drugs in the last 06 hours before the study.

Keywords: fever ibuprofen acetaminophen dipyrone
psychosocial situation of children with rare (congenital) pediatric surgical diseases and their families

Conditions: Rare Diseases

Summary: families of children with rare diseases (i.e., not more than 5 out of 10.000 people are affected) are often highly burdened with fears, insecurities and concerns regarding the affected child and his/her siblings. the aim of the present research project is to examine the psychosocial burden of the children with rare (congenital) pediatric surgical diseases and their family in order to draw attention to a possible psychosocial care gap in this population.

the central objective of the cross-sectional study is to show the psychosocial supply gap for families with children and adolescents affected by rare diseases in the field of pediatric surgery. among the rare diseases that are included are diaphragmatic hernia, anorectal malformations, esophageal atresia, hirschsprung's disease and biliary atresia. in order to have a comparative sample, additional data of a matched control group are collected. central standardized psychosocial outcomes will be assessed from the perspectives of the parents, the affected child and the siblings.

Eligibility criteria:
inclusion criteria (families of rare disease): * family with at least one child between 0 and 21 years with a rare pediatric surgical disease. * consent to participate in the study. * sufficient knowledge of the german language of parents and children. exclusion criteria (families of rare disease): * severe acute physical, mental and/or cognitive impairment of the child, so that the questionnaire survey does not appear possible and/or unreasonable at this stage. inclusion criteria (control group): * family with at least one child between 0 and 21 years who have undergone a surgical procedure in the first 3 years of life that does not cause chronic complaints * consent to participate in the study. * sufficient knowledge of the german language of parents and children. exclusion criteria (control group): - families of children with a congenital or chronic disease.

Keywords: rare diseases pediatric surgery children and adolescent quality of life psychological distress
exploring the effect of combined chinese and western treatment on home medical care

Conditions: Hypertension

Summary: combine antihypertensive drugs and acupuncture to isolated systolic hypertension elderly patients at home

the investigators would like to compare the effectiveness of acupuncture and drug therapy on blood pressure. the investigators chose acupuncture point according the traditional chinese medicine theory, besides, each patient was using 1-3 antihypertensive drug of a heterogeneous pharmacological group ranging from angiotensin-converting enzyme inhibitor (ace inhibitor), diuretics, and beta blockers.

Eligibility criteria:
inclusion criteria: 1. patient with isolated blood pressure diagnosis by physicians and bp \>140/\<90 mmhg 2. patient took the drug to control blood pressure for more than one year 3. age\>65 years old 4. willing to participate in this study exclusion criteria: 1. suspected acute stroke 2. chest pain or dyspnea 3. ingestion of short-acting antihypertensive medication within 2 h prior to the beginning of the study 4. body temperature \>37.5∘c(99.5∘f)

Keywords: acupuncture, hypertension, elderly, home health care
does teaching before or after simulation improve learning?

Conditions: Medical Education; Simulation

Summary: the goal of the randomized educational intervention study is to test whether simulation preceding didactic teaching leads to improved knowledge and performance retention compared to a didactic lecture proceeding simulation for medical students participants will be randomized to one of two different groups with reverse orders for simulation and lectures. researchers will compare each group to see which way is better for learning.


Eligibility criteria:
inclusion criteria: - second year medical student at the university of british columbia exclusion criteria: - none

Keywords: medical education simulation pediatrics
assessment of the effect of tegaserod (2 mg tid and 6 mg tid) on dyspeptic symptoms in diabetic patients with symptoms of diabetic gastropathy

Conditions: Diabetic Gastropathy

Summary: this study is being done to evaluate the safety, tolerability and satisfactory relief of tegaserod against dyspeptic symptoms in diabetic patients with symptoms of diabetic gastropathy.


Eligibility criteria:
inclusion criteria: * history of type 1 or insulin-requiring type 2 diabetes for at least 3 years * gi symptoms for at least 2 months before entering study exclusion criteria: * very high body weight * significant diarrhea * ulcers symptom severity score collected via diary other protocol-defined inclusion/exclusion criteria may apply.

Keywords: diabetes, tegaserod, gastropathy
canadian humira post marketing observational epidemiological study : assessing humira real-life effectiveness and impact on hs burden of illness

Conditions: Hidradenitis Suppurativa (HS)

Summary: this study assesses humira's® real-life effectiveness in the management of dermatological manifestations of moderate to severe hidradenitis suppurativa (hs).


Eligibility criteria:
inclusion criteria: * has a clinical diagnosis of moderate to severe hs according to the treating physician judgment * need a change in ongoing therapy for any reason, but not limited to inadequate response, intolerance, sub-optimal compliance, or patient preference. patient will be approached to participate in the study after a decision to change patient's therapy for humira® is made by the treating physician. * has provided written informed consent (patient authorization) for participation in the study exclusion criteria: * is participating in a clinical interventional study * was treated with humira®, or any other biologic agents for hs prior to baseline visit * has any other active skin disease or condition that, in the opinion of the treating physician, prohibits the patient from participating in the study or obscures the assessment of the treatment of hs

Keywords: hidradenitis suppurativa (hs) humira® canada
large cohort of 1000 patients with severe myopia

Conditions: Myopia, Severe

Summary: the prevalence of myopia and severe myopia are increasing and will affect 50% and 10% of the population respectively. severe myopia exposes an increased risk of glaucoma, cataract, retinal detachment and myopic maculopathy, a source of visual impairment. to date, no european cohort study has been conducted to estimate the rate of these complications and to study the predictive parameters.

this study allows to describe the evolution of different ophthalmological parameters of a population of strong myopes during their follow-up for 10 years using multimodal imaging techniques of the retina. prospective, longitudinal, multicentric, non-randomized cohort study with constitution of a biological collection. this study will include major and minor patients with high myopia

Eligibility criteria:
inclusion criteria: * age ≥ 6 years * severe myopia in at least one eye, defined as * a refractive error ≤ -6.00 diopters or * an axial length ≥ 26.50 mm * follow-up performed at at least one of the participating centers * express consent to participate in the study * if age \< 18 years: express consent of the person(s) exercising parental authority * affiliated or beneficiary of a health insurance exclusion criteria: * visual acuity \< 5 letters on the etdrs (equivalent to "finger count" or less) in both eyes * disorders of the transparent media in both eyes with opacities that may affect image quality * syndromic myopia of genetic origin (stickler syndrome type 1 and 2, marfan syndrome, ehler-danlos disease type 4, knobloch syndrome) or inherited retinal dystrophy (x-linked retinitis pigmentosa, congenital stationary night blindness of schubert-bornshein type, bornholm eye disease) * patient who does not wish to continue to be followed in one of the participating centers * patient benefiting from a legal protection measure * pregnant or breastfeeding woman
the effects of io fibrewater supplementation on gut health, immunity and metabolism in overweight adults

Conditions: Healthy

Summary: despite availability of many alternative and conventional weight loss options, the prevalence of obesity increased from 15% in 1993 to 27 in 2015. in 2015, 68% of men and 58% of women in the uk were overweight or obese. overweight and obesity increase the risk for comorbidities such as hypertension, dyslipidaemia, cardiovascular disease, type 2 diabetes and certain cancers. hormonal regulation of appetite has been shown to influence body weight and body fat . gut hormones secreted from the intestine are particularly important both in the regulation of appetite and blood glucose level, and recently the gut hormone glucagon like peptide -1 (glp-1) has been successfully targeted to treat both type 2 diabetes and obesity. targeting the gut microbiota has been shown to influence gut hormones, in a way is likely to help treat or prevent obesity and type 2 diabetes. in past decades, considerable attention has been given to investigating the new applications of natural prebiotic polymers on gut microbiota composition. moreover, recent trend in research indicates a bidirectional communication between the gut microbiota and the central nervous system through the microbiome-gut-brain axis (mgba). therefore an in vivo intervention feeding study is proposed performed with a variety of psychological and nutritional tests aiming to compare io fibrewater with an equivalent placebo control water and also highlight both cognitive function, emotional bias and response to appetite and also metabolic profiles of the gut microbiota.

study design: a 30-day placebo-controlled randomised trial study in overweight adults who have not been diagnosed with diabetes. participants: 20 participants will be invited to take part in this study. they will be randomly assigned to treatment (n=10) or control (n=10) groups, where they will consume io fibrewater or volvic sugar free lemon \& lime water for 4 weeks. both water samples (1 bottle/day) need to be taken with the meals (lunch).

Eligibility criteria:
* inclusion criteria 1. females and males, aged 18 years to 65 years 2. bmi ≥25 kg/m2 with any of the following: 1. igt (blood glucose level of 7.8-11.0 mmol/l after a 2-hour oral glucose tolerance test (ogtt)), or 2. ifg (fasting blood glucose level of 5.6-6.9 mmol/l) or 3. impaired hba1c (hba1c level of 5.7%-6.4%) 3. not dieting within the last month 4. not having lost \>5% body weight in the previous year 5. not increased physical activity levels in the past 2-4 weeks or intending to modify them during the study. 6. understands and is willing, able and likely to comply with all study procedures and restriction including being willing to follow the nutritional advice. 7. able to eat most everyday foods with no current ibs symptoms. 8. habitually consumes three standard meals a day (i.e., breakfast, lunch, and dinner) * exclusion criteria current use of prescribed medication for neuropsychiatric disorders or history of neuropsychiatric disorders
ultraviolet-c effectiveness in the management of pressure ulcers in people with spinal cord injury

Conditions: Pressure Ulcer

Summary: the objective of the study is to examine the effectiveness of ultraviolet-c (uvc) for healing pressure ulcers in people with spinal cord injury. uvc is a form of radiation similar to sunlight but it is normally absorbed in the earth's atmosphere. participants will be assigned by chance to receive placebo-uvc or real uvc treatment, in addition to receiving wound care according to best practice guidelines. the hypothesis is that uvc-treated wounds will heal at a faster rate than wounds receiving placebo treatment. given that pressure ulcers impact on an individual's quality of life, and generate high costs to the overall health care system, further work is needed to explore alternative means of pressure ulcer treatment.

uvc or placebo uvc will be applied to wounds three times per week. intact skin around the wound edge and the wound base will be irradiated.

Eligibility criteria:
inclusion criteria: * traumatic, non-traumatic or congenital spinal cord injury c2-l2 * pressure ulcer stage 2 or higher exclusion criteria: * neoplastic wound * wound surgically repaired within past 3 months * wound currently treated with negative pressure therapy

Keywords: skin decubitus pressure sore spinal cord injury
a study of bms-512148 (dapagliflozin) in patients with type 2 diabetes and inadequately controlled hypertension on an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to learn whether dapagliflozin, after 12 weeks, can improve (decrease) blood pressure in patients with type 2 diabetes with uncontrolled hypertension who are on an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. the safety of this treatment will also be studied.


Eligibility criteria:
key inclusion criteria * participants willing and able to give signed and written informed consent * males and females, aged 18 to 89 years, who have type 2 diabetes with inadequate glycemic control (hemoglobin a1c between 7% and 10.5%) and uncontrolled hypertension (seated systolic blood pressure of 140 to 165 mm hg and seated diastolic blood pressure 85 to 105 mm hg) * mean 24-hour bp\>=130/80 mmhg determined by abpm * stable dose of oral antidiabetic agent (oad) for at least 6 weeks (12 weeks for thiazolidinedione) or a stable daily dose of insulin as monotherapy or in combination with another oad, for 8 weeks, and a stable dose of an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker for at least 4 weeks * c-peptide level ≥0.8 ng/ml * body mass index ≤ 45.0 kg/m\^2 key exclusion criteria * aspartate aminotransferase or alanine aminotransferase level \>3\*upper limit of normal (uln) * serum total bilirubin level \>1.5\*uln * serum creatinine ≥2.0 mg/dl unless subject was on metformin, where exclusionary limits were serum creatinine ≥1.50 mg/dl for men and ≥1.40 mg/dl for women * estimated creatinine clearance of \<60 ml/min * hemoglobin ≤10.0 g/dl for men and ≤9.0 g/dl for women * creatine kinase \>3\*uln * positive for hepatitis b surface antigen * positive for antihepatitis c virus antibody * abnormal free t4 value * history of diabetes insipidus * symptoms of poorly controlled diabetes that would preclude participation in this trial, including but not limited to, marked polyuria and polydipsia with greater than 10% weight loss during the 3 months prior to enrollment. * history of diabetic ketoacidosis or hyperosmolar nonketotic coma * history of malignant and accelerated hypertension * known or suspected secondary hypertension * any of the following within 6 months of enrollment visit: * myocardial infarction * cardiac surgery or revascularization (coronary artery bypass surgery /percutaneous transluminal coronary angioplasty) * unstable angina * unstable congestive heart disease or new york heart association class iii or iv * transient ischemic attack or significant cerebrovascular disease * unstable or previously undiagnosed arrhythmia

Keywords: diabetes mellitus, type 2 diabetes mellitus endocrine system diseases glucose metabolism disorders metabolic diseases angiotensin receptor antagonists angiotensin-converting enzyme inhibitors hypoglycemic agents pharmacologic actions physiological effects of drugs
naltrexone and bupropion combination on obese,smoking patients with schizophrenia

Conditions: Obese; Cigarette-smoking; Schizophrenia

Summary: the purpose of this research is to observe the efficacy of naltrexone and bupropion combination on weight loss and smoking cessation from baseline to week 24 compare to placebo.

this is a randomized, double-blind, and placebo-controlled study. subjects with evaluation and confirmation that inclusion and exclusion criteria are met, will be treated with naltrexone sustained release 15mg once per day and bupropion sustained release 150mg once per day in the first two weeks, and naltrexone 25mg once per day and bupropion 300mg once per day during the rest of the study.the purpose of this research is to observe the efficacy of naltrexone and bupropion on weight loss and smoking cessation compared to placebo.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia by the international classification of diseases 10th revision (icd-10); * age between 18 and 65 years old; * on stable antipsychotic medication treatment for at least one month; * bmi \> 28 kg/m2 according to bmi criterion for obesity in the chinese population ， or bmi\>27 kg/m2 in the presence of dyslipidemia, or male with waist circumference over 90cm; * smoking at least 10 cigarettes daily for one year or longer; * desire to lose weight and quit smoking. exclusion criteria: * binge eating or other eating disorders; * current use of weight loss or antidiabetic medications; * current substance use (except nicotine or caffeine); * elevated hepatic transaminase levels (\>2.5x normal range); * clinically significant thyroid stimulating hormone（tsh） and/or thyroxine4（t4） abnormalities; * history of seizure disorder; * history of unstable cardiac problems or other unstable medication conditions; * being pregnant or nursing (for women).