Kornimate/medical-research-clean huggingface dataset:
the role of left prefrontal transcranial magnetic stimulation in episodic migraine prophylaxis

Conditions: Episodic Migraine; Prophylaxis

Summary: the aim of the study was to examine the prophylactic role of repetitive transcranial magnetic stimulation (rtms) on the frequency, and severity of migraine attacks in episodic migraineurs who failed medical treatment. a group received 5 rtms sessions, delivered over one week. each rtms session consisted of a single train of 900 total pulses over 3 minutes duration given at 5-hz frequency and 100% motor threshold intensity and the placebo group received rtms with the same stimulation frequency at a fixed intensity of 50% of the machine output


Eligibility criteria:
inclusion criteria: * cases diagnosed as episodic migraine with or without aura according to the ichd 3rd edition * with a headache frequency of 4-14 per month for the last six months * patients who had either an unsatisfactory response, declined or were intolerant to at least two prophylactic medications. exclusion criteria: * patients with past family history of seizures * other chronic pain disorders * severe depression (beck depression inventory of 30 or more) * other significant neurologic or psychiatric diagnosis including substance misuse * metal implants in the head * pregnant or breastfeeding ladies * prior experience with tms

Keywords: rtms = repetitive transcranial magnetic stimulation ldlpfc = left dorsolateral prefrontal cortex hit 6 = headache impact test nprs = numeric pain rating scale ichd = the international classfication of headache disorder mt= motor threshold
snap: measurement of the subjective perception of the symptom in hereditary spastic paraparesis (hsp)

Conditions: Hereditary Spastic Paraparesis

Summary: the self-notion and perception (snap) questionnaire developed at irccs e.medea by eleonora diella and roberta morganti, arises from the need to quantify the subjective perception of the patient suffering from hsp of the typical symptoms of pathology, such as spasticity, weakness, changes in balance, resistance in walking, pain and fatigue. the purpose of this study is to validate this instrument and test its reliability, looking for correlations with the measurement scales used in the literature for the evaluation of the patient with hsp. the most used for this population are the spastic paraplegia rating scale (sprs) and the six-minute walk test (6mwt) which assess the severity of the disease and the level of endurance (8-9) respectively.


Eligibility criteria:
inclusion criteria: * diagnosis of genetically determined hereditary spastic paraparesis or subjects without defined genetics but who unequivocally show at the time of evaluation a dominant or recessive familiarity with exclusive involvement of the pyramidal system * age\> 9 years * iq\> 80 * the patient must be able to walk for at least 10 meters. indoors, even with help exclusion criteria: * age less than 9 years * iq \<80, * loss of gait * psychopathological aspects that can affect the validity of the data collected

Keywords: outcome measure, hereditary spastic paraplegia
sexually transmitted infections among african american women who have sex with women

Conditions: Sexually Transmitted Infections; HIV Infections

Summary: the purpose of this study is to determine the rates of sexually transmitted infections (sti) among a group of african american women who have sex with women (aa wsw). the first study hypothesis is that aa wsw are at risk for acquiring and transmitting sti, including the human immunodeficiency virus (hiv). the second study hypothesis is that aa wsw participate in multiple high-risk sexual activities that may facilitate transmission of stis, including hiv.

historically, women who have sex with women (wsw) have been thought to be at low risk for acquiring sexually transmitted infections (sti), presumably due to the absence of genital mucosal contact present during vaginal-penile sex or due to the assumption that the vaginal mucosa experiences a lesser degree of trauma during female sex than during heterosexual sex. this assumption has been challenged and debated over the past two decades. in addition, the sexual health risks of wsw are only beginning to be understood. to date the majority of research regarding sti in women has occurred in heterosexuals. national and local surveillance data that estimate the risk for sti transmission between wsw are limited, especially among african americans. this is a group of women that may exhibit distinctive behavioral characteristics that may put them at higher risk for sexually transmitted infections sti and hiv than their caucasian counterparts. this group of women has traditionally been reluctant to discuss their sexual orientation with physicians for fear of being stigmatized. the burden of stis, including hiv, experienced by this group of women is largely unknown.

Eligibility criteria:
inclusion criteria: * female * age 18 years or older * african american race * sexual contact with another female within the past 6 months * ability to give written informed consent exclusion criteria: * male * age less than 18 years old * race other than african american * no sexual contact with another woman within the past 6 months * pregnant * prior enrollment in this study * participants who, for any reason, in the opinion of the investigator, do not have the ability to give written informed consent or may not be expected to comply with the requirements of the protocol

Keywords: african american women who have sex with women sexually transmitted infections homosexuality human papillomavirus cervical intraepithelial neoplasia herpes simplex virus types 1 and 2 chlamydia gonorrhea trichomoniasis bacterial vaginosis syphilis human immunodeficiency virus
clinical & pathological studies of upper gastrointestinal carcinoma

Conditions: Stomach Cancer; Gastro-Esophageal(GE) Junction Cancer; Gastric (Stomach) Cancer; Esophageal Cancer; Gastrointestinal Stromal Tumor (GIST)

Summary: our research of the biology of upper gastrointestinal cancers involves the study of tissue samples and cells from biopsies of persons with gastric or esophageal cancer or blood samples from upper gastrointestinal cancer patients and persons at high inherited risk for these cancers. we hope to learn the role genes and proteins play in the development of gastric and esophageal cancer.


Eligibility criteria:
inclusion criteria: 1. over 18 2. diagnosed with gastric or esophageal cancer or at an increased hereditary risk for upper gi cancer exclusion criteria: 1. under 18 2. no family or personal history of gastric or esophageal cancer
continuous glucose monitoring in dialysis patients to overcome dysglycemia trial

Conditions: Hemodialysis; Diabete Mellitus; Continuous Glucose Monitoring

Summary: this randomized controlled trial will investigate whether use of continuous glucose monitoring (cgm) vs. usual care with self-monitored blood glucose 1) enhances glycemic control, 2) reduces hypoglycemia risk, and 3) improves quality of life, diabetes distress, and fear of hypoglycemia in hemodialysis patients with diabetes mellitus.

this is a parallel, two-arm randomized controlled trial comparing real-time cgm using dexcom devices vs. usual care (self-monitored blood glucose 4-times/day) among 122 in-center hemodialysis patients with diabetes mellitus over a 12-week period. our primary objective will be to determine the effects of cgm vs. usual care on glycemic control, defined by percent (%) of time in target glucose range (70-180 mg/dl). our main and exploratory secondary objectives will be to determine the effects of cgm on cgm-indices of hypoglycemia, blood-based glycemic markers (hba1c, glycated albumin, fructosamine), and patient-reported outcomes (health-related quality of life, diabetes distress, hypoglycemia fear). we will also evaluate feasibility endpoints by measuring cgm compliance during the intervention period and success/ease of implementing cgm training sessions among patients.

Eligibility criteria:
inclusion criteria: * ability to provide written informed consent * age ≥18 years old * end-stage kidney disease status receiving in-center hemodialysis ≥4 weeks * type 1 or type 2 diabetes * actively performing self-monitored blood glucose (smbg) testing for ≥4 weeks * ≥70% compliance wearing continuous glucose monitoring (cgm) device during the pre-trial period exclusion criteria: * inability to provide informed consent or comply with the study protocol * limited visual acuity * inability to wear cgm device * prior use of cgm * active pregnancy or planning a pregnancy
community-based engagement to improve lung cancer screening and outcomes

Conditions: Lung Cancer Screening

Summary: the goal of this pilot study is to understand the impact of a mobile lung cancer screening clinics in individuals from neighborhoods and communities with less access to resources in boston, massachusetts who are at high risk for lung cancer. the main questions it aims to answer includes: * is mobile lung cancer screening is feasible and acceptable? * is collecting social needs data during the mobile lung cancer screening clinics feasible? participants will: * complete an intake survey, providing information about their demographic, medical, and social needs information. * undergo a shared decision-making conversation to determine whether lung cancer screening should be done. * undergo lung cancer screening. * undergo a debriefing conversation and fill out an acceptability survey. * undergo a semi-structured phone interview between four and eight weeks after lung cancer screening date.


Eligibility criteria:
inclusion criteria: * ability to understand and the willingness to sign a written informed consent document prior to any study-related procedures. * willing to undergo treatment. * adults between the ages of 50 and 80 years. * no recent ct or mri imaging within the last year. * currently smokes tobacco or has quit smoking tobacco within the past 15 years. * has a tobacco smoking history of at least 20 pack years (i.e. one pack per day for the last 20 years or equivalent). * has never been diagnosed with lung cancer. exclusion criteria: * adults/children less than 50 years, or greater than 80 years of age. * has never smoked tobacco. * has smoked tobacco but quit more than 15 years ago. * has a tobacco smoking history of less than 20 pack years. * presence of major comorbidity(ies) that could prevent treatment. * previous diagnosis of lung cancer. * in the opinion of the investigator, the subject is not an appropriate candidate for the study.

Keywords: lung cancer screening
emotional response in psychiatric and control participants

Conditions: Schizophrenia; Emotions

Summary: the purpose of this research is to understand how the emotions of people with different mental health concerns (e.g., people with schizophrenia, people with major depressive disorder) differ from individuals without mental health concerns. a large body of literature suggests that people with mental illnesses have emotional abnormalities compared to healthy individuals, but a number of these abnormalities are not well understood. for example, often people with schizophrenia report on questionnaires that they experience fewer pleasant emotions when talking with other people, but some evidence suggests these individuals report a similar amount of pleasant emotion when they are actually engaged in a pleasant activity. thus, it is unclear the extent to which reports of emotional abnormalities extend to a more real-world setting. in the tasks in the current proposal, participants will engage in a series of tasks designed to assess their emotional functioning. these tasks involve viewing emotional stimuli on the computer, engaging in social interactions, and consuming small amounts of food. in all tasks, participants will make ratings of their experiences of pleasure (and displeasure). we will then compare the experiences of patient groups to those of healthy individuals to test how emotional ratings might differ across these tasks.


Eligibility criteria:
inclusion criteria: * for control participants, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in english, and you have not been clinically diagnosed with a psychiatric disorder. * for psychiatric patients, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in english, and you have been clinically diagnosed with schizophrenia, schizoaffective disorder, or depression with no recent hospitalization or changes in your psychiatric medications. exclusion criteria: * for control participants, you are not eligible to participate in the study if you have a history of stroke or a current history of substance or alcohol dependence. you are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months. you are not eligible to participate if you have a current or past history of a major medical illness, significant tremors, a history of a head injury or prolonged unconsciousness. * for psychiatric patients, you are not eligible to participate in the study if you have had major changes to your psychotropic medications within the last two months, have a history of stroke or a current history of substance or alcohol dependence. you are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months, a current or past history of a major medical illness, significant tremors, or a history of a head injury or prolonged unconsciousness.
effect of pecs ii, parasternal and serratus plane blocks on postoperative pain in midcab surgery

Conditions: Pain, Postoperative; Coronary Artery Disease

Summary: aim: it was aimed to evaluate the effectiveness of pectoral nerve block (pecs ii), parasternal and serratus plane blocks in postoperative analgesia in minimally invasive cardiac surgery (midcab). introduction: the frequency of minimally invasive cardiac surgery has increased in recent years. with this method, coronary artery bypass graft (cabg) operations can be performed without sternotomy. it is a beneficial method for early postoperative mobilization, early recovery and better aesthetic appearance. since there is a surgical intervention between the ribs, pain control is important in these patients. method: in the preoperative evaluation of patients planned for cabg, pecs ii, parasternal and serratus plane blocks are routinely recommended for postoperative pain control. consent for the procedure is obtained from patients who accept this procedure. after induction and before the surgical incision, these block applications are performed under sterile conditions under the guidance of ultrasonography. standard intravenous analgesic agents are applied to our patients who do not accept block applications. the hospital core system files of our patients who underwent cardiac surgery with minimally invasive intervention in our hospital between january 1, 2021 and december 31, 2021 will be scanned retrospectively. patients with and without block application will be divided into two groups. from our patients' files; demographic data, extubation time, drain site and incision site pain at the 1st, 2nd, 4th, 12th, 24th, 48th and 72nd hours after extubation will be noted. in addition, it will be noted whether there is a need for additional rescue analgesia in cases where block is performed. the data obtained will be evaluated statistically and the results will be published in national or international scientific journals.


Eligibility criteria:
inclusion criteria: * adult patients aged 18 and over * patients who underwent midcab surgery exclusion criteria: * patients under 18 years of age * patients who did not undergo midcab surgery
laser therapy following radiotherapy for gynecological cancer

Conditions: Pelvic Radiotherapy; Gynecological Cancer; Dyspareunia; Vaginal Dryness

Summary: women with a history of pelvic radiotherapy due to gynecological cancer, will receive laser therapy for the management of genitourinary syndrome of menopause.


Eligibility criteria:
inclusion criteria: * history of gynecological cancer treated with pelvic radiotherapy * last radiotherapy \>1 year * women sexually active or willing to resume sexual activity * symptoms of dyspareunia, vaginal dryness, itching/burning and vaginal bleeding related to sexual intercourse exclusion criteria: * relapse of gynecological cancer * prolapse stage \>1 * active genital infection (i.e herpes, vaginitis) * underlying pathologies that could interfere with patients compliance to the protocol (i.e any psychiatric condition)
early diagnosis of alzheimer's disease: clinical, neuropsychological and neuroimaging follow-up of a cohort of patients with an isolated memory impairment

Conditions: Alzheimer's Disease

Summary: the aim of this project is to follow cohort of patients with amci in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy and metabolic change

the syndrome of "amnestic mild cognitive impairment" (amci) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal ad.

Eligibility criteria:
inclusion criteria: * patients beforehand include in the phrc 2001 study (these patients presented to the inclusion in the phrc 2001 a qualified board of amnestic mild cognitive impairment \[amci\] or light cognitive confusion of type amnestic) * the patient must be affiliated to an insurance scheme disease to participate in this study exclusion criteria: * for the magnetic resonance imaging: usual contraindications for an examination by mri: claustrophobia, metal foreign bodies, pacemakers, etc. * incapacitated to realize the neuropsychological evaluation because of medical intercurrentes disorders * appointment of a guardian
characteristics and disease progression of mixed connective tissue disease and systemic lupus erythematosus

Conditions: Mixed Connective Tissue Disease (MCTD); Systemic Lupus Erythematosus (SLE)

Summary: systemic lupus erythematosus (sle) and mixed connective tissue disease (mctd) are long-term autoimmune diseases in which the immune system attacks parts of the body. the abnormal immune reaction causes inflammation of and damage to various body parts and can affect joints, skin, kidneys, heart, lungs, blood vessels, and the brain. sle and mctd often affect young women, especially black and hispanic women, and there is no known cure. knowing more about sle and mctd will help in developing new and effective treatments. the purpose of this study is to characterize immune system abnormalities, genetic components, and disease progression in people with sle and mctd.

systemic lupus erythematosus (sle) is an autoimmune disease in which the immune system produces antibodies against the body's healthy cells and tissues. these antibodies, called autoantibodies, contribute to the inflammation of various parts of the body and can cause damage to organs and tissues. mixed connective tissue disease (mctd) is another autoimmune disease that overlaps in terms of signs and symptoms with three other connective tissue diseases, including sle. in both sle and mctd, the immune system appears to be abnormally activated by small nuclear ribonucleoprotein (snrnp) autoantigens. furthermore, lung tissue, in particular, appears to be affected by the immune response induced by snrnp autoantigens. the causes of sle and mctd remain unknown. however, it is likely that a combination of genetic, environmental, and possibly hormonal factors work together to cause the diseases. past studies suggest that several different genes may be involved in determining a person's likelihood of developing sle or mctd, which tissues and organs are affected, and the severity of the disease. the purpose of this study is to characterize immune system abnormalities, genetic components, and disease progression in people with sle and mctd. participants will attend up to four study visits, at intervals of at least 3 months, over the course of this study. each study visit will include questionnaires, a physical exam, and possibly blood and/or urine collection. at the end of the study period, participants may choose to continue or discontinue participation.

Eligibility criteria:
inclusion criteria: * patients with known rheumatic diseases including systemic lupus erythematosus, rheumatoid arthritis, connective tissue disease, undifferentiated connective tissue disease exclusion criteria: * poor venous access, unstable medical problems or significant cardiopulmonary disease, anemia, leukopenia, thrombocytopenia, anticoagulation therapy, recent significant changes in medication or pregnacy. patient cannot be taking large dose of corticosteroids (above 30mg per day) or cytotoxic drugs (cyclophosphamide, azathiprine, cyclosporine, methotrexate).

Keywords: anti-rnp/sm autoantibody-positive mctd sle
study of outcome and safety of lithium, divalproex and risperidone for mania in children and adolescents

Conditions: Bipolar Disorder

Summary: this study will evaluate the effectiveness of the medications, lithium (eskalith®), valproate (depakote®), and risperidone (risperdal®) in treating children and adolescents with bipolar disorder or symptoms of mania.

patients are randomly assigned to receive lithium (eskalith), valproate (depakote), or risperidone (risperdal) for 8 to 16 weeks. they will have weekly visits to monitor their response to the medication. when the study is complete, care will be transferred to the child's treating psychiatrist.

Eligibility criteria:
inclusion criteria: * dsm-iv criteria for bipolar i (manic or mixed) or mania for at least 4 weeks * cgas less than or equal to 60 * good physical health exclusion criteria: * schizophrenia or any pervasive developmental disorder * major medical or neurological disease * history of addiction to illicit substances or alcohol or drug abuse within the last 4 weeks * iq less than 70 * pregnancy or breast-feeding * unacceptable methods of contraception * in-patient care at baseline

Keywords: mania