Kornimate/medical-research-clean huggingface dataset:
the relationship of critical shoulder angle with proprioception and disability

Conditions: Rotator Cuff Impingement Syndrome; Shoulder Impingement Syndrome; Subacromial Impingement Syndrome

Summary: with this study it will determined that the effect of critical shoulder angle which will be obtained from the mri images of patients with subacromial impingement syndrome on proprioception and disability level.

critical shoulder angle (csa) is defined as the intersection angle between two lines which are drawn from inferior border of glenoid cavity to superior border of glenoid cavity and from inferior border of glenoid cavity to inferolateral border of acromion. higher csa is accepted a predisposing factor for degenerative shoulder diseases. increase in csa means more shear forces reflects on shoulder joint which also causes overload on the rc tendon. increase of degeneration in shoulder joint may cause decreased proprioception. as a result of degeneration, the level of disability will be increased. at the end of this study, the relationship among critical shoulder angle, proprioception and disability could be more clearly interpreted.

Eligibility criteria:
inclusion criteria: * being between 25-70 years of age. * being level i-ii subacromial impingement * having shoulder pain for 3 months. exclusion criteria: * having a shoulder operation before. * having cardiovascular, rheumatological or neurological disease * having cervical spine disease * having physiotherapy treatment in last 6 months. * having a trauma, fracture, total rotator cuff rupture, frozen shoulder on shoulder joint

Keywords: shoulder joint critical shoulder angle proprioception disability
fever after misoprostol administration for the treatment of primary postpartum hemorrhage

Conditions: Postpartum Hemorrhage

Summary: this study will evaluate side effects after sublingual misoprostol (600 mcg) as a first-line treatment for primary postpartum hemorrhage (pph) due to suspected uterine atony.

the study purpose is to confirm whether a lower, 600 mcg dose of sublingual misoprostol will reduce the incidence of elevated body temperature (≥40°c) associated with misoprostol. the study will compare the incidence of high fevers following treatment with 600 mcg sublingual misoprostol to previously documented rates using 800 mcg sublingual misoprostol. an additional line of research is to investigate whether some women are more susceptible to experiencing high fevers following misoprostol administration, and whether genetic factors are responsible for misoprostol-induced fevers.

Eligibility criteria:
inclusion criteria: * able and willing to give informed consent * vaginal delivery * postpartum hemorrhage due to suspected uterine atony * oxytocin given during 3rd stage of labor exclusion criteria: * known allergy to prostaglandins or misoprostol * underwent cesarean section * postpartum hemorrhage not due to suspected uterine atony * oxytocin not given during 3rd stage of labor * severe ill health * unable to give informed consent

Keywords: primary postpartum hemorrhage pph uterine atony high fever hyperpyrexia
measuring blood pressure in the lung circulation with sonar technology (echo-doppler)

Conditions: Pulmonary Arterial Hypertension

Summary: this is a non-invasive study using a standard doppler echocardiographic transducer which records signals emanating from the lungs (tpd). these signals are caused by pulsation of blood vessels in the lung tissue. the innovations in this study are: 1. the software processing of the reflected ultra-sound waves from the lung rendering a reproducible, clear and strong signal in sync with the cardiac cycle, 2. the observation based on pilot studies that blowing hard against resistance during recording (something called a valsalva maneuver), affects the lung signal weakening it and even obliterating it as the pressure rises. the investigators hypothesis is that since the signal comes from the blood vessels in the lung, the pressure at which the recorded signal disappears during the valsalva maneuver represents the blood pressure in the lungs.

current methods for noninvasive measurement of pulmonary arterial blood pressure by standard echo-doppler equipment are fraught with uncertainty. so much so that patients being screened and followed for pulmonary arterial hypertension require right heart catheterization. an invasive and uncomfortable and potentially dangerous procedure. this study is designed to confirm our preliminary observation that there is good correlation between valsalva maneuver pressure and pulmonary arterial blood pressure. sixty patients undergoing right heart catheterization for clinical reasons will be studied. the study itself is short, about 30 minutes, painless and done with the patient either sitting up in bed or semi-reclining. the probe is positioned over the right chest wall and the patient is requested to successively blow into a mouthpiece at rising pressures, to tolerance. the results obtained using tpd to asses pulmonary arterial pressure will be compared to the results obtained at catheterization. this is part of the development phase of the technology.

Eligibility criteria:
inclusion criteria: eligibility * age 18 years or older * patients who are clinically suspected of having elevated pulmonary blood pressure , due to cardiac or cardio-pulmonary disease preferably any one or more of the conditions listed below, and due to have right heart catheterization as part of the diagnostic work-up: * patients with chf * patients with primary pulmonary arterial hypertension * patients with copd * patients with asthma * patients with interstitial lung disease * patients with sarcoidosis * signed informed consent. exclusion criteria: * patients unable to cooperate. * inability to assume a sitting or supine position * patients with severe chest wall deformity

Keywords: pulmonary arterial blood pressure doppler
a study to test the safety and tolerability of brivaracetam in children and adolescents with seizures

Conditions: Epilepsy

Summary: the purpose of the study is to evaluate the long-term safety and tolerability of brivaracetam.

ep0156 is designed to assess the long-term safety and tolerability of brv in pediatric study participants with epilepsy who participated in the neonatal study n01349 \[ncg03325439\] and/or have participated in the open-label, long-term, follow-up pediatric study n01266 \[nct01364597\]. ep0156 will also assess the long-term safety and tolerability of brv in japanese pediatric study participants with partial-onset seizures who will be directly enrolled into the study in japan. pharmacokinetic data will also be evaluated in japanese study participants.

Eligibility criteria:
inclusion criteria: inclusion criteria for long-term follow-up (ltfu) study participants only * study participants ≥ 1 month of age with a confirmed diagnosis of epilepsy who participated in core study n01266 \[nct01364597\] and/or n01349 \[nct03325439\] inclusion criteria for directly enrolled (de) study participants in japan only * study participant is ≥ 4 years to \< 16 years of age * study participant has presence of an electroencephalogram (eeg) reading compatible with the diagnosis of focal epilepsy within the last 10 years * study participant has uncontrolled partial-onset seizure (pos) after an adequate course of treatment with at least 1 antiepileptic drug (aed) * study participant had at least 1 pos during the 4-week screening period exclusion criteria: exclusion criteria for all study participants * severe medical, neurological, or psychiatric disorders or laboratory values, which may have an impact on the safety of the study participant * study participant is currently participating in another study of an investigational medication (or a medical device) other than brivaracetam (brv). exclusion criteria for long-term follow-up (ltfu) study participants only - study participant ≥ 6 years of age has a lifetime history of suicide attempt or has suicidal ideation in the past 6 months as indicated on the columbia suicide severity rating scale (c-ssrs) exclusion criteria for directly enrolled (de) study participants in japan only * study participant has a history of primary generalized epilepsy, psychogenic non-epileptic seizures, or febrile seizures * study participant has a history of status epilepticus in the 30 days prior to the screening visit (scrv) or during the screening period * study participant has any clinically significant illness * study participant has clinically significant laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results * study participant has a clinically significant ecg abnormality * study participant had major surgery within 6 months prior to the scrv

Keywords: epilepsy brivaracetam pediatric child
performance of refractometers with self-adjusting lenses compared to cycloplegia in children (refralens)

Conditions: Refractive Errors; Ametropia

Summary: this study aimed to compare refractive measurements using vision-s™ 700, an immersive and compact phoropter with a tunable-focus lens, and vision-r™ 800, a phoropter with a tunable-focus lens without immersion, with cycloplegic refraction serving as the gold-standard. this a retrospective study aimed to enroll 41 children, aged 6 to 16 years, who underwent refractive assessments with vision-s™ 700, vision-r™ 800, and cycloplegic refraction. the primary objective involves a comparison of the spherical equivalent between both devices and compared to cycloplegic refraction. secondary outcomes include the analysis of astigmatism components (j0° and j45°) and subgroup analyses in myopic and hyperopic children.


Eligibility criteria:
inclusion criteria: * 6 to 16 years old patients followed in the brest university hospital center, in france, between the 1st of november 2022 and the 30th of april 2023 and requiring a cycloplegic refraction not presenting an exclusion criteria exclusion criteria: * age below 6 years or above 16 years * presence of other ophthalmological pathologies rather than ametropia * non-french language proficiency, and absence of parental authorization
screening program of relative energy deficiency in sports in college athletes

Conditions: Relative Energy Deficiency in Sports

Summary: the investigators hope that through this study will know the prevalence of relative energy deficiency in sports (red-s) and its impact on sports injuries, performance and illness among college athletes in taiwan. and also to find an appropriate diagnosis and intervention model to take care of athletes' health and improve sports performance taiwan's athletes in the future.

this project is divided into 3 steps for a period of two years. the first step (0-6 months) is expected to recruit a total of 100 college athletes from taekwondo, judo, rhythmic gymnastics, and long-distance runners for relative energy deficiency in sports (red-s) screening. the second step (7-18 months) is targeted at athletes who have been screened for potential red-s risk (the number is tentatively 30) in the first step. the diagnostic tools refer to the clinical assessment of relative energy deficiency in sport clinical assessment tool (red-s cat). the third stage (19-21 months) is intervention programs targeted at the athletes who are diagnosed with red-s (the number is tentatively 20) at 2nd step. the intervention programs consist of nutrition monitoring and diet intervention. the investigators hope that through this study will know the prevalence of red-s and its impact on sports injuries, performance and illness among college athletes in taiwan. and also to find an appropriate diagnosis and intervention model to take care of athletes' health and improve sports performance taiwan's athletes in the future.

Eligibility criteria:
inclusion criteria: * (1) agree to participant this study and sign the informed consent form * (2) college athletes in national taiwan sport university * (3) over the age of 18 exclusion criteria: * (1) disagree to participant or unwilling to cooperate with the screening, intervention and tracking of this study * (2) diabetes * (3) thyroid disease * (4) hereditary anemia * (5) pregnancy

Keywords: relative energy deficiency in sports anorexia menstrual disorder sport injury
betamethasone to control postoperative pain in emergency endodontic care

Conditions: Pain

Summary: the objective of this randomized double-blind study was to evaluate the effect of betamethasone in the control of postoperative pain in patients undergoing endodontic treatment.

to prevent post endodontic treatment pain, systemic administration of corticosteroids may have their effect maximized if the infiltration is performed in the oral mucosa, near the periapex of the tooth, which concentrates the inflammatory process. the administration of corticosteroids at this moment, taking advantage of the anesthetic effect still present, ensures continuous comfort during the postoperative period. the objective of this randomized double-blind clinical trial was to evaluate the effect of the systemic administration of betamethasone - through infiltration in the oral mucosa - to control pain and edemas in patients undergoing emergency endodontic treatment.

Eligibility criteria:
inclusion criteria: * individuals had to have a tooth with pain of endodontic origin justifying emergency care; * individuals diagnosed with irreversible pulpitis or necrosis associated to pericementitis. exclusion criteria: individuals who presented: * pregnancy or lactation; * use of corticosteroids; * history of hypersensitivity to the drugs used in this study; * pain associated with abscesses of endodontic origin; * individuals with tuberculosis; * individuals with systemic fungal infections; * individuals with simple ocular herpes; * individuals with glaucoma; * individuals with acute psychosis. * individuals with psychotic tendencies.

Keywords: steroids pain measurement
bioequivalency study of oxcarbazepine 600 mg tablets under fed conditions

Conditions: Seizures; Epilepsy

Summary: the objective of this study was to assess bioequivalence of a potential generic 600 mb oxcarbazepine tablet formulation compared with novartis pharmaceutical's 600 mg oxcarbazepine tablet, trileptal, following a single 600 mg dose, administered with food.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal finding on the physical examination, medical history, or clinical laboratory results at screening. exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with any known enzyme altering drugs. * history of allergic or adverse response to oxcarbazepine or any other comparable or similar product.
efficacy and safety, long-term study of npc-01 to treat dysmenorrhea associated with endometriosis

Conditions: Dysmenorrhea

Summary: the purpose of this long-term study is to determine whether npc-01 is effective in the treatment of dysmenorrhea associated with endometriosis.


Eligibility criteria:
inclusion criteria: * dysmenorrhea associated with endometriosis exclusion criteria: * severe hepatopathy * pregnant woman
effect of core stability exercises and treadmill training on balance in children with down syndrome

Conditions: Physical Therapy

Summary: introduction: core stability exercises and treadmill training play a crucial role in physical therapy interventions and have an effect on balance in children with down syndromes (ds), whether core stability exercises or treadmill training has more effect on improve balance has not been investigated yet. the aim of the study was to investigate the effect of core stability training versus treadmill exercises on balance in children with down syndrome. methods: forty-five children with down syndrome included in the study. the children aged 4-6 years, and they were equally divided randomly into three groups (a), (b) and (c). group a received traditional physical therapy intervention strategies to facilitate the balance of participated children. group (b) received same as the group (a), with additional core stability exercises training. group (c) received same intervention strategies as group (a) in conjunction with a treadmill exercise program. the children's balance was evaluated using the berg balance scale and the biodex balance system. treatment sessions were for 60 min, thrice a week, for eight consecutive weeks.


Eligibility criteria:
inclusion criteria: * able to recognize commands given to them, * able to understand our verbal command and encouragement, and * able to stand and walk independently without repeated falling exclusion criteria: * any neurological or musculoskeletal disorders (signs of epilepsy and instability of atlantoaxial joint), * any mobility disorders * any cardiac anomalies * any vision or hearing loss
home visits to optimize medical and educational success among sacramento schoolchildren with asthma

Conditions: Asthma; Chronic School Absenteeism

Summary: this study will establish a multi-disciplinary home visitation team consisting of a medical provider and school teacher or staff member, and will evaluate whether a series of visits from this team will help decrease school absenteeism among children with asthma.


Eligibility criteria:
inclusion criteria: * students in elementary school (k-6) in the sacramento city unified school district * identified as at risk for chronic absenteeism based on previous year and/or first 8 weeks of school year * have a current diagnosis of asthma exclusion criteria: * underlying chronic conditions such as cystic fibrosis, chronic lung disease with oxygen dependence, immunodeficiency syndromes

Keywords: home visit school absenteeism
translation and validation of the french version of confusion assessment method for the intensive care unit

Conditions: Patients With Mental Confusion

Summary: validity and reliability of french version of the confusion assessment method for the intensive care unit (psychometric validation study after translation/back translation process assessed by the original team : w.ely, md, ph.d, vanderbilt university)


Eligibility criteria:
inclusion criteria: * adult, \> or equal to 18-yr * richmond agitation sedation scale (rass) \> or equal -3 * francophone exclusion criteria: * diagnostic of cognitive disorders * admission for brain injury * psychotic disorders * diagnostic of cognitive disorders * visual or auditory impairments
quantified balance measures during stance and gait: multiple sclerosis patients. a longitudinal clinical study

Conditions: Balance Control

Summary: the primary objective of this project is to track changes over time in balance control parameters measured during stance and gait for different groups of multiple sclerosis (ms) patients. our primary goal is to determine whether these changes in balance control over time predict transitions in ms progression to a more disease affected state, and are different from changes over time for patients with balance deficits due to vestibular sensory disorders. a part of this goal is also to determine whether these changes in balance control are correlated with changes in patients' self-reported deficits and are similar to those changes in balance control of patients with peripheral vestibular loss. the secondary objective is to determine for multiple sclerosis (ms) patients the relationship of their balance parameters to different gait speeds, in order to advise them on, and promote via feedback, safe walking speeds. fulfilling the first of our objectives would lead to better tracking of ms disease changes over time, earlier quantification of onset of symptoms suggesting a worsening of disease status, and, we assume, greater patient satisfaction knowing that quantification of symptoms fits subjective feelings of balance deficits during stance and gait. achieving the second objective would lead to improved balance during gait. we aim to carry out these objectives using equipment (swaystar) which we have proven is sensitive to ms induced balance deficits {2}, but costs far less to operate and maintain than previously used quantification tools. we aim to investigate the balance deficits during gait in different ms patient groups using a multimodal approach with a swaystar system (analysis of balance during stance and gait in terms of trunk-pelvis movements near the centre of mass) and patient questionnaires.


Eligibility criteria:
inclusion criteria: * balance deficits due to inner ear disease or ms exclusion criteria: * inability to walk without a walking aid
factors influencing adherence to adjuvant endocrine therapy

Conditions: Adherence, Treatment

Summary: breast cancer is the most common type of cancer and the leading cause of cancer death in women. adjuvant endocrine therapy (aet) reduces the risk of disease recurrence and mortality in women with hormone-dependent breast cancer. this cross-sectional study aims to investigate adherence to aet and identify factors associated with adherence in the republic of croatia. the level of adherence, beliefs about medicines, and quality of life with aet will be investigated with validated instruments in the form of an anonymous survey. given the available data on suboptimal adherence to aet in europe and globally, it is clear that there is a need for investigating adherence in croatia which hasn't been done so far. each country, population, and health system has its own characteristics, and understanding the experience of using aet and identifying associated psychosocial factors could help in developing specific interventions supporting women and improving aet adherence.


Eligibility criteria:
inclusion criteria: * women older than 18 years of age * clinical diagnosis of hormone receptor positive early breast cancer stages 0-iii according to the american joint committee on cancer (ajcc) classification * prescribed with adjuvant endocrine therapy for more than 3 months exclusion criteria: * advanced metastatic breast cancer, stage iv according to the american joint committee on cancer (ajcc) classification * other life-threatening illnesses * mental disorders * behavioral disorders caused by the use of psychoactive substances * behavioral syndromes related to physiological disorders and physical factors * cognitive impairment * organic and symptomatic mental disorder * schizophrenia * disorders similar to schizophrenia * delusional disorders * personality disorders * behavior disorders * mental retardation * psychological development disorders * unspecified mental disorders * incapable of autonomously reaching decisions
comparison of immune response following surgical management of renal tumors

Conditions: Kidney Cancer

Summary: examine the effects of renal surgery on the immune system.

prospective study examining the effects of different surgical procedures on immune function. this may have bearing on overall cancer specific recurrence and survival.

Eligibility criteria:
inclusion criteria: * kidney tumor patients scheduled for open or laparoscopic surgery exclusion criteria: -

Keywords: kidney cancer, immunology