Kornimate/medical-research-clean huggingface dataset:
sensitivity and specificity of serum and salivary cyfra21-1 in the detection of malignant transformation in oral potentially malignant mucosal lesions (diagnostic accuracy study)

Conditions: Oral Potentially Malignant Lesions; Oral Cancer

Summary: the study is designed to measure serum and salivary cyfra21-1 levels using enzyme linked immunosorbent assay (elisa) in patients with oral malignancy, oral potentially malignant lesions, and control subjects to evaluate the potential of cyfra21-1 as a diagnostic marker for malignant transformation in potentially malignant oral mucosal lesions.


Eligibility criteria:
inclusion criteria: participants will be divided into 3 groups: * group i: patients suffering from oral potentially malignant lesions (pml) as defined by world health organization. * group ii: patients suffering from diagnosed oral malignant lesions * group iii: healthy subjects who are systemically free, non-smokers, and not suffering from any oral mucosal lesions. exclusion criteria: * subjects taking any drugs inducing any changes that could affect the salivary flow. * pregnant females. * subjects have any allergies, infectious diseases or active dental abscesses during one month before saliva sampling. * patients receiving any drugs related to the oral lesions in the past 6 month prior to sample collection.

Keywords: oral potentially malignant lesions oral cancer salivary cyfra21-1 serum cyfra21-1
non-interventional observational study with viramune (nevirapine) and various drug combinations in the antiretroviral combination treatment of hiv-infected patients who have already been treated for approx. 10 years with viramune

Conditions: HIV Infections

Summary: the question that prompted this study is the extent to which results from clinical trials can be translated into everyday practice (external validity). an observation period of about 10 years extends far beyond the duration of clinical trials. first and foremost are questions about tolerability and the efficacy of an antiretroviral combination treatment with viramune and other antiretroviral partners. in particular, adverse events will be recorded and the therapeutic effect will be monitored via the course of viral load and improvement of the immune system, based on the cd4 cell count.

study design: observational

Eligibility criteria:
inclusion criteria the inclusion criteria for treatment with viramune plus other antiretroviral combination drugs are to be based on the current information for healthcare professionals/spc (r08-0843) exclusion criteria the exclusion criteria for treatment with viramune plus other antiretroviral combination drugs are to be based on the current information for healthcare professionals/spc (r08-0843).

Keywords: treatment experienced
recanalization of distal cerebral vessels in acute stroke using aperio®

Conditions: Acute Stroke

Summary: the purpose of the revisar pmcf is to collect data in clinical practice of the aperio® and aperio® hybrid(17) thrombectomy device, which are intended to restore blood flow in the neurovasculature by removing thrombus in patients experiencing ischemic stroke. recanalization status will be assessed at the end of the procedure using the modified tici (thrombolysis in cerebral infarction) score.

study type: prospective, multicenter, single-arm, open-label, national participants: 11 participating centers in germany pi: dr. franziska dorn, university hospital bonn, germany estimated enrolment: a minimum of 130 patients treated with the aperio® or aperio® hybrid(17) thrombectomy device due to thrombotic occlusions in a distal vessel of the anterior and posterior circulation (postbifurcal mca, aca, pca) follow up: 3 months estimated final assessment: end of 2022 this is a prospective, multicenter, single-arm, open-label, national post-market clinical follow-up study to collect comprehensive information on technical and clinical success and safety of the use of aperio® and aperio® hybrid(17) thrombectomy device in a distal vessel of the anterior and posterior circulation (postbifurcal mca, aca, pca). aperio® and aperio® hybrid(17) thrombectomy device will be used within its approved indication.

Eligibility criteria:
inclusion criteria: * any patient treated with the aperio® or aperio® hybrid(17) thrombectomy device due to occlusion in distal vessel of the anterior and posterior circulation (postbifurcal mca, aca, pca) according to ifu * age ≥ 18 years exclusion criteria: * pre stroke mrs ≥ 3 * any contraindication according to ifu
comparison of hyperemic efficacy between central and peripheral adenosine infusion for fractional flow reserve (ffr) measurement

Conditions: Coronary Artery Disease; Myocardial Ischemia

Summary: the purpose of this study is to evaluate the safety and effectiveness of the peripheral iv continuous infusion without the insertion of central venous vascular access method in the achievement of steady-state maximal coronary hyperemia compared with the central iv continuous infusion method.


Eligibility criteria:
inclusion criteria: * non -infarct related, patients with moderate coronary artery stenosis * normal ejection fraction on echocardiogram exclusion criteria: * infarct-related arteries or clinically unstable state * collateral blood flow to the target vessel is shown * atrioventricular block on electrocardiogram * reduced ejection fraction(\<50%) or left ventricular hypertrophy on echocardiography * contraindication of adenosine

Keywords: adenosine fractional flow reserve, hyperemia fractional flow reserve, myocardial
integrating motivational interviewing with cognitive-behavioral therapy

Conditions: Anxiety Disorders and Symptoms; Depression; Life Style

Summary: cognitive-behavioral therapy (cbt) is efficacious for anxiety disorders and depression, but not all patients achieve remission, and dropout is considerable. motivational interviewing (mi) may strengthen motivation to change, and influence non-response and dropout. research shows that mi as a pretreatment to cbt produces moderate effects compared to cbt alone. studies integrating mi with cbt (mi-cbt) throughout treatment are scarce. the present study explored the feasibility of mi-cbt in routine psychiatric care, and compared cbt alone to mi-cbt for anxiety disorders, depression, and unhealthy lifestyle behaviors. the anxiety, depression, diet, alcohol, physical activity, and tobacco (addapt) feasibility study had a randomized controlled design, and data were analyzed using hierarchical regression.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * a principal diagnosis according to the diagnostic and statistical manual of mental disorders, fourth edition, text revision (dsm-iv-tr) of panic disorder, social anxiety disorder, obsessive-compulsive disorder, generalized anxiety disorder, posttraumatic stress disorder, or major depressive disorder * at least one of the following unhealthy lifestyle behaviors: unhealthy eating habits, hazardous use of alcohol, insufficient physical activity, or tobacco use, according to screening criteria suggested by the national board of health and welfare exclusion criteria: * psychotic symptoms * dsm-iv-tr criteria for substance abuse other than alcohol * dsm-iv-tr criteria for substance dependence including alcohol * moderate to severe suicide risk according to the mini-international neuropsychiatric interview or a score of 2 or above on item 9 on the patient health questionnaire 9 * another simultaneous psychological treatment
mental stress reduction in defibrillator patients

Conditions: Cardiomyopathy, Dilated; Arrhythmia; Anger; Stress

Summary: the purpose of this study is to assess the effectiveness of a 10 week program of stress management versus control patient education sessions on cardiac responses to mental stress in veterans with implantable cardioverter-defibrillators

the study is a randomized controlled small clinical trial designed to determine whether a 10-week program of group cognitive-behavioral stress management (cbsm) versus a control "patient education" program can improve hemodynamic responses to mental stress testing in patients with implantable cardioverter defibrillators. comparison will be made between groups of heart rate and blood pressure responses to mental arithmetic and anger-recall mental stress, psychometric profiles, arrhythmia frequency and implantable cardioverter defibrillator firings before, immediately and up to 6 months after intervention. if benefit of cbsm is proven, study findings could lead to wider use of stress management programs, with increased life expectancy for implantable cardioverter-defibrillator patients.

Eligibility criteria:
inclusion criteria: * age \>21 years, * icd implantation, * \> 3 months following icd implantation, * willingness to give informed consent exclusion criteria: * episodes within prior 3 months of: acute coronary syndrome, myocardial infraction, coronary artery by-pass graft surgery, percutaneous coronary intervention, hospital admission any cause, * severe mental illness, * life expectancy \< 1 year, * hyperkalemia, * hypokalemia, * hypomagnesemia, * hypermagnesemia, * unwillingness to give informed consent

Keywords: stress, psychological tachycardia, ventricular defibrillators, implantable death, sudden cardiac cognitive therapy anger
the usefulness of the new ehs/ahs classification of primary umbilical hernias in the selection of method of their treatment

Conditions: Retrospective Analysis of Material From the Hospital Database

Summary: the aim of the study is to assess the usefulness of the new classification of primary umbilical hernias in the choice of treatment of patients. the study is conducted as a retrospective analysis of material from the hospital database

a retrospective analysis will include patients operated on in the department of general surgery of the hospital of the brothers hospitallers in the period from january 2016 to december 2022. the incidence of recurrence will be assessed based on outpatient records and a telephone survey. hernias will be classified according to the ehs/ahs guidelines as small, medium and large. the qualification will take into account the old and new classification of hernias.

Eligibility criteria:
inclusion criteria: * repair surgery for primary umbilical hernia exclusion criteria: * repair surgery for recurrent umbilical hernia
effects of lactobacillus delbruckii lactis dn111244 fermented milk consumption on plasma lipids levels in hypercholesterolaemic adults

Conditions: Hypercholesterolemia

Summary: the objective of this study is to investigate the effect of lactobacillus delbruckii lactis (dn111244) fermented milk consumption on relative change of plasma ldl-cholesterol concentration in hypercholesterolaemic adults after 8 weeks of product consumption versus control product.


Eligibility criteria:
inclusion criteria: * male and female aged 18-75 years; * bmi between 19 and 30 kg/m2, * ldl-cholesterol plasma level between 130 mg/dl to 190 mg/dl (bounds included) with or without statin monotherapy, * stabilized hypercholesterolemia (since more than 3 months), * accepting to follow the dietary recommendations advisable for hypercholesterolemic patient (ncep-atp iii guidelines), * used to consume dairy products, * for female: effective contraceptive methods used, * agreeing to a written informed consent exclusion criteria: * plasma triglycerides (tg) levels \> 350 mg/dl (4 mmol//l), * any cardiovascular event (infarction, angina, surgical or endocoronary intervention, stroke, peripheral arteriosclerosis, etc) in the last 6 months, * known allergy or hypersensitivity to milk proteins, * systemic treatment or topical treatment likely to interfere with evaluation of the study parameters, * subject currently involved in a clinical trial or in an exclusion period following participation in another clinical tria, * subject in a situation which in the investigator's opinion could interfere with optimal participation in the present study or could constitute a special risk for the subject, * diabetic subjects (type i and type ii), * any kind of disease likely to interfere with the evaluation of efficiency or safety of the product, * for female subject: pregnancy, breast feeding or intention to become pregnant during the study, * for female subject: subject likely to change her contraceptive method during the study, * active heavy cigarette smokers (reported more than 20 cigarettes / day), * subjects who are actively participating in a weight loss program or have participated in a weight loss program in the three months prior to screening for the study

Keywords: midly hypercholesterolemic subjects probiotic cholesterol lowering dairy
assessment of the professional difficulties of adult with attention deficit / hyperactivity disorder patients

Conditions: Attention Deficit Hyperactivity Disorder in Adults

Summary: attention deficit/hyperactivity disorder (adhd), which is common and well known in children, persists into adulthood in more than 60% of cases, with significant impact on quality of life. professional domain is particularly impaired. the investigators hypothesize that adhd symptoms causes professional difficulties, on the emotional, cognitive, physical and relational levels. the main objective of this study is to better characterize these professional difficulties at to follow-up these difficulties after one year. difficulties will be assessed by questionnaires and semi-directive interview. the secondary objective is to determine what factors modulate these difficulties and what compensation strategies are implemented to address the patients.


Eligibility criteria:
inclusion criteria: * patients aged 18 to 62 years * diagnosis of attention deficit disorder with or without hyperactivity by a psychiatrist * no treatment for adhd in childhood or adolescence * patient who has been in a professional situation during the last 3 months exclusion criteria: * patient on sick leave or unemployed for more than 3 months * depressive episode in acute phase * subject with a mobility project that prevents follow-up for 1 year (planned move) * impossibility of providing the subject with informed information (subject in an emergency situation, difficulties in understanding the subject, mental retardation, illiteracy or insufficient command of the french language...) * subject under the protection of justice * subject under guardianship or curatorship

Keywords: prospective descriptive non-interventional monocentric
risk-adapted therapy of acute myeloid leukemia of adults (18-60 years) according to the cytogenetic result

Conditions: Acute Myeloid Leukemia

Summary: the concept of the investigators risk-adapted multicenter treatment trial for younger adults, aml hd98a, is based on the results of the aml hd93 trial and on published data. definition of risk groups is different compared to the aml hd93 trial; high-risk: refractory disease after first induction therapy and/or high risk karyotype \[abn(3q), -5/5q-, -7/7q-, abn(12p), abn(17p), complex\]; intermediate-risk: complete remission after induction therapy and intermediate risk karyotype \[normal, abn(11q23), abn(16q22), other rare aberrations\]; low-risk: complete remission after induction therapy and low risk karyotype \[t(8;21)\]. patients exhibiting a t(15;17) were treated in a separated trial (apl hd95). treatment consists of a first induction therapy with ice followed by a second cycle ice in case of response to first induction therapy. patients with refractory disease after first induction therapy are assigned to a salvage therapy with a-ham (all-trans retinoic acid, high-dose cytarabine and mitoxantrone) and the search for potential hematopoietic stem cell donors is extended from the family to unrelated persons. all patients achieving a cr after induction therapy with ice are assigned to a first consolidation therapy with ham. for intermediate-risk patients a peripheral stem cell or a bone marrow harvest are intended during the hematological recovery after the first consolidation. second consolidation therapy was stratified according to the risk definition. for high risk patients a allogeneic transplantation is assigned from a related or unrelated donor preferentially after a dose-intensified conditioning therapy. all patients with intermediate risk and an hla-matched family donor are assigned to allogeneic transplantation. intermediate-risk patients without a family donor and normal karyotype at diagnosis are randomized between an autologous stem cell transplantation and a second course of ham. the other intermediate-risk patients are assigned to autologous transplantation. for low-risk patients a second course of ham is assigned.


Eligibility criteria:
inclusion criteria: * patients with aml, de novo or secondary after myelodysplasy, or with therapy-induced aml after healed primary malignom; or refractory anemia with excess of blasts in transformation (raeb-t); the diagnosis must be confirmed morphological, cytochemical and with immunological phenotyping * cytogenetical tests must be performed for each patient * age: 16 - 60 years * all patients have to be informed about the character of the study. written informed consent of each patient at study entry. exclusion criteria: * organic insufficiency: insufficiency of the kidneys (crea \> 1.5 x upper normal serum level), or insufficiency of the liver (bilirubin, sgot or ap \> 2 x upper normal serum level) uncaused by the aml; severe obstruction or restrictive ventilation disorder, heart failure with a ejection fraction \< 0.5 * secondary malignom * other severe diseases * pregnancy * participation in an concurrent clinical study
seasonal variations and different treatment protocols of intussusception in children: our centers experiences

Conditions: Intussusception

Summary: intussusception remains a common cause of bowel obstruction in children and results in significant morbidity and mortality if not promptly treated. there is a paucity of prospective studies regarding childhood intussusception. this study describes the seasonal variation and management outcomes of childhood intussusception

intussusception is the invagination of a segment of bowel into an adjacent segment resulting into an intestinal obstruction. it is the most common acquired cause of intestinal obstruction in children aged four months to two years with a peak of incidence between four and nine months of age. etiology of intussusception is reported to be idiopathic in about 90% of cases and rarely is it associated with pathological lead points such as meckel's diverticulum, appendix, solid bowel lesions, intestinal polyp, and intestinal lymphoma. it is an occlusive-strangulation type of intestinal obstruction, and all necessary measures should be taken early to ensure prompt diagnosis and treatment to avoid ischaemia and necrosis of bowel. the term comes from two latin words, intus, which means "inside" and suscipere, which means "to receive". it has been reported in neonates and adults . the ancient greeks, treated intestinal obstruction with enema or insufflations of air into the anus. abdominal pain, vomiting and blood in stools are the classic triad and are uncommon and seen in less than one-third of the children affected. cases often present with non-specific symptoms, including vomiting, pain, irritability, decreased appetite and lethargy, and this may render diagnosis of intussusception difficult. abdominal ultrasound is considered the standard choice for its diagnosis. non-surgical management with pneumatic reduction (pr) by air, hydrostatic reduction by saline or contrast enema is the best procedure.surgical management by exploratory laparotomy with simple reduction while some cases may require a bowel resection and reanastomosis for gangrenous bowel.

Eligibility criteria:
inclusion criteria: * inclusion criteria: the verified diagnosis of intussusceptions in patients by clinical examination and ultrasonography exclusion criteria: * patients were excluded if the diagnosis of intussusceptions was not validated or patients who were above 12 years of age.
assessing the impact of weighted blankets on anxiety among inpatients with anorexia nervosa: a study protocol

Conditions: Anorexia Nervosa; Avoidant/Restrictive Food Intake Disorder; Anxiety

Summary: the aim of this study is to conduct a randomized control trial (rct) to assess the efficacy of weighted blankets (wb), on anxiety for patients with severe anorexia nervosa (an) and avoidant restrictive food intake disorder (arfid) in an inpatient medical setting. we hypothesize that using weighted blankets will reduce anxiety in these patient populations.

anorexia nervosa (an) has one of the highest mortality rates of any psychiatric disorder with anxiety being a common comorbidity. the standard of care for inpatient medical stabilization for patients diagnosed with an is a multidisciplinary approach with emphasis on nutrition, psychotherapy, and medical management of complaints. weighted blankets, an example of deep pressure stimulation, have been shown to reduce anxiety. however, not much is known about the effect of weighted blankets in the eating disorder population. therefore, this randomized control trial (rct) protocol outlines a study design for assessing the effect of weighted blankets on patients with an. a two-arm rct design will be implemented for this study. a convenience sample of 24 patients will be enrolled with 12 patients in the control and intervention groups based on inclusion criteria. the control group will receive denver health's standard of care for patients admitted to its well-known medical stabilization unit for patients with extreme form of eating disorders, while the intervention group will receive both the standard of care and a weighted blanket. a mixed-design anova will be performed to explore differences in the beck's anxiety inventory and subjective units of distress scale between the intervention and control groups.

Eligibility criteria:
inclusion criteria: * clinically diagnosed with an-r, an-bp, or arfid upon admission (per diagnostic and statistical manual-v criteria) * moderate/major anxiety per initial evaluation score using bai * ot assessment exclusion criteria: * pregnant or nursing mothers

Keywords: anorexia nervosa weighted blankets occupational therapy anxiety deep pressure stimulation randomized control trial
adherence to new oral anticoagulation therapy in turkey

Conditions: Atrial Fibrillation

Summary: this study will compose a national database of drug adherence and investigate the factors that affect drug adherence in patients taking new oral anticoagulation therapy in turkish population.

noacs have several clinical and pharmacological advantages over warfarin however suboptimal adherence is one of the most common causes of failure to respond to medications and outcomes. this observational multicenter, retrospective study, will compose a national database of drug adherence and investigate the factors that affect drug adherence in patients taking new oral anticoagulation therapy in turkey. social support and adherence to therapy factors that may affect drug adherence and adverse events will be assessed by self-report questionnaires. non-adherence will be tested for demographic, clinical, awareness of noac therapy and socioeconomic factors.

Eligibility criteria:
inclusion criteria: * patients \>18 years old * outpatients using a noac for at least 3 months duration, with a primary diagnosis of new-onset, non-valvular atrial fibrillation * patients signed patient informed sheet and informed consent form exclusion criteria: * patients under 18 years old * patients refused to sign informed consent form

Keywords: atrial fibrillation drug adherence new oral anticoagulants drug adherence