Kornimate/medical-research-clean huggingface dataset:
evaluation of tests performance on a new digital orthoptic platform

Conditions: Binocular Vision Disorder; Visual Impairment

Summary: this clinical trials aims to evaluate tests performance on a new digital orthoptic platform.

the demography of ophthalmologists is becoming weaker, many tasks are now performed by orthoptists. to optimize the achievement of orthoptic exams and thus make reliable screening in a shorter time, digital tools are developed. they attempt to renew the orthoptic screening equipment that is still made up of numerous tests, often with old designs that must be handled and adapted to each patient which constitutes a significant loss of time. it therefore appeared necessary for us to develop a platform of digital tools that integrates major tests used for diagnostic purposes, especially a visual acuity test, a stereoscopic vision test, a fusion test and a digital synoptophore enabling a detailed analysis of disorders of binocular vision. the purpose of the study is to evaluate this new tool, avoiding the mobilization of patients , and quantify whether this platform is precise, reliable, fast, comfortable and allow the realization of a safe examination for the patient and for orthoptics.

Eligibility criteria:
inclusion criteria: * patients with less than or equal to 16 ocular deviation prism diopters, without or with slight amblyopia (maximum difference of 2 logarithmic visual acuity lines) and performing an orthoptic exam at ophthalmology department of brest university hospital. exclusion criteria: * monophthalmic * medium and deep amblyopic patients * patients with not normal ocular motility * patient who underwent surgery at the head and neck during the previous three months * children under 7 years old.

Keywords: digital orthoptic platform vision test
a predictive study of peripheral blood biomarkers on postoperative neurocognitive dysfunction in elderly frail and non-frail patients undergoing gastrointestinal surgery

Conditions: Perioperative Neurocognitive Disorders; Frail Elderly

Summary: perioperative neurocognitive impairment (pnd) mainly includes acute postoperative delirium (pod) and persistent postoperative cognitive impairment (pocd), which are common postoperative complications in elderly patients. perioperative neurocognitive impairment (pnd) is attracting increasing attention, but its exact mechanism is still unclear. the diagnosis of pnd lacks the gold standard, so it is difficult to determine the incidence rate. at present, the diagnosis is mainly conducted through the scale. therefore, this study aims to explore the correlation between peripheral blood biomarkers and pnd in elderly frail patients undergoing gastrointestinal surgery.


Eligibility criteria:
inclusion criteria: * age ≥ 65 years old * american society of anesthesiologists (asa) classification: grades i-iv * hospitalization time ≥ 3 days exclusion criteria: * the revised version of the cognitive function telephone questionnaire (tics-m) was used before surgery to determine cognitive impairment (tics-m score ≤ 27 points) * refuse to participate * emergency surgical patients * central nervous system diseases (dementia, depression, etc.) * severe renal insufficiency (requiring dialysis) * long term use of psychotropic drugs (such as clozapine, risperidone, olanzapine, haloperidol, chlorpromazine, etc.) * history of alcohol abuse or use of acetylcholine drugs * the same patient can only be included once, regardless of whether the reason for the second surgery is related to the first cause

Keywords: peripheral blood biomarkers inflammatory markers alanine aminotransferase blood lipids vitamin d
safety and efficacy of hunterase

Conditions: Hunter Syndrome

Summary: the objective of this study is to determine the safety and efficacy of once weekly dosing of idursulfase-beta 0.5mg/kg administered by intravenous(iv) infusion for hunter syndrome patients \< 6 years old.


Eligibility criteria:
inclusion criteria: 1. the patient has a diagnosis of hunter syndrome based upon biochemical criteria: * as measured in plasma, leukocytes, or fibroblasts, * a deficiency in iduronate-2-sulfatase (i2s) enzyme activity of ≤ 10 % of the lower limit of the normal range * that corresponds to one or more of the following: * a normal enzyme activity level of one other sulfatase * confirmed as mps2 by genetic test results * shows clinical symptoms/ visible signs of mps2 2. \< 6 years old and male 3. patients who are able to comply with the study requirements 4. the patient's parent(s), or patient's legal guardian must have given voluntary written consent to participate in the study exclusion criteria: 1. the patient has had a tracheostomy 2. the patient has known severe hypersensitivity or shock to any of the components of idursulfase 3. the patient has received treatment with another investigational therapy within 30 days prior to enrollment 4. history of a stem cell transplant 5. the patient has known severe hypersensitivity or shock to any of the components of test drug(excipient etc)

Keywords: hunter syndrome idursulfase-beta hunterase gc1111
genetics in the effect of caffeine on fat oxidation

Conditions: Genetic Predisposition; Caffeine; Fat Burn

Summary: genetic polymorphism on the effect of oral caffeine intake on fat oxidation during exercise has been studied in active and healthy population performing an incremental test on a cycle ergometer with 3-min stages at workloads from 30 to 70% of maximal oxygen uptake (vo2max). participants performed this test after the ingestion of a) placebo; b) 3 mg/kg of caffeine; c) 6 mg/kg of caffeine. fat oxidation rate during exercise was measured by indirect calorimetry. the influence of the cyp1a2 c.-163a\>c, gstp c.313a\>g and pgc1a polymorphisms was evaluated to determine the effects on fat oxidation during exercise

caffeine is a natural stimulant with well-recognized sports performance benefits. aside its performance-enhancing effect, caffeine has the potential of increasing fat utilization during aerobic exercise at submaximal intensities, lowering-down the contribution of carbohydrate as a fuel. this property of caffeine may provoke a glycogen-sparing effect in the skeletal muscle and liver for exercise situations where carbohydrate availability may be a challenge. additionally, the capacity of caffeine to enhance fat utilization during exercise could be of interest for improving health outcomes as it may increase the rate of change in body composition in exercise programs. genetic factors like cyp1a2 c.-163a\>c, gstp c.313a\>g and pgc1a c.1444g\>a and c\>t polymorphisms could be associated with the capacity for fat oxidation during exercise. to date, it is unknown if genetics increases fat oxidation and mfo in the same proportion during morning and evening exercise trials in women. for this reason, the aim of the present study was to evaluate the influence of the tcyp1a2, gstp and pgc1a polymorphisms on the effect of caffeine on fat oxidation and mfo in active and healthy population. the authors hypothesised that genetics would increase fat oxidation and mfo during exercise and this effect would be of similar magnitude at several caffeine doses.

Eligibility criteria:
inclusion criteria: to be non-smokers. to have low caffeine intake (i.e., \< 50 mg of caffeine per day in the previous 2 months) to show no previous history of cardiopulmonary diseases or having suffered musculoskeletal injuries in the previous 6 months. exclusion criteria: to have vo2max values below 40 ml/kg/min to be sedentary
cold water immersion in the recovery of markers of muscle damage of 10km street runners

Conditions: Health Behavior

Summary: objective: to analyze the effect of cold water immersion (cwi) on the recovery of clinical, biochemical, functional and neuromuscular markers of muscle damage in 10 km street runners. materials and methods: this is a randomized, blinded trial in which 30 subjects, 10 km street runners, were randomly divided into three groups: control (gc), immersion (gi) and cwi (gcwi). the runners will be evaluated for clinical (subjective perception of exertion), biochemical (serum ck), functional (unipodal triple hop distance and shuttle test time) and neuromuscular variables by means of isokinetic variables (peak torque, total work and fatigue index). volunteers will perform pre-assessment, immediately post-race and post-intervention, and 24-hour post-intervention. the data will be expressed by mean and standard deviation, analyzed in the statistical package spss 20.0. a significance level of 5% and a 95% confidence interval will be considered for all measures.


Eligibility criteria:
inclusion criteria: * body mass index between 18.5 and 30 kg/m2; * street runners for at least 6 months; * week frequency of at least 3 times; * do not present cardiopathies, muscles and neurological diseases; exclusion criteria: * hypersensitivity or allergies to cryotherapy; * unable to complete the 10 km event on the day of the evaluation; * do not complete or perform any of the study procedures for any reason (phobias, do not withstand the exposure time).

Keywords: physical activity muscle pain cryotherapy
fetal anomalies scan at the time of nuchal translucency study

Conditions: Fetal Anomalies

Summary: purpose: fetal anomalies scan at the time of nuchal translucency (nt) study.

prospective study of patients at 12-14 weeks gestation that are coming for nt examination is conducted. meticulous ultrasound examination will be done to the fetuses using trans vaginal and transabdominal techniques. the patients will receive only the nt information. only in cases of detection of severe fetal anomalies the patient will get the information of the examination and counseling according to the findings. all patients will be asked to provide information of the 15 weeks early comprehensive ultrasound examination. the nt examination will be compared to the 15 weeks ultrasound. all patients will be asked to give information after delivery of the baby's health condition.

Eligibility criteria:
inclusion criteria: * pregnant women at 12-14 weeks exclusion criteria: -

Keywords: fetal anomalies scan at the time of nt study
active choice clinical decision support (cds): hepatocellular carcinoma (hcc) screening in patients with cirrhosis

Conditions: Hepatocellular Carcinoma; Cirrhosis

Summary: the research team will evaluate the effectiveness of an auto-pended bot liver ultrasound order that will prompt providers at the time of encounter to place appropriate imaging orders for hepatocellular carcinoma (hcc) screening in patients with cirrhosis.


Eligibility criteria:
inclusion criteria: * cirrhosis diagnosis, * 6 months or more after since most recent imaging. exclusion criteria: * previous liver transplant, * hcc diagnosis, * receiving hospice care, * completed external imaging in the past 6 months.
vitamin b6 can prevent hand and foot syndrome in cancer patients capecitabine chemotherapy

Conditions: Hand and Foot Syndrome

Summary: capecitabine (xeloda) a drug in cancer therapy. its use is limited often by its toxicities. this study is asking if vitamin b6 can prevent one of the common toxicities of xeloda which is numbness and/or rash of the hands and feet, a condition called hand and foot syndrome. patients , starting capecitabine chemotherapy for their cancer, will participate in this study at john h. stroger jr. hospital of cook county. they will be randomized to receive either vitamin b6 or a placebo. investigators and patients will be blinded to the intervention.

double-blind, placebo-controlled trial, with randomly assignment of eligible patients who were treated with capecitabine to receive either daily pyridoxine 100 mg or placebo along with their capecitabine-containing chemotherapy regimen. patients were observed during the first 4 cycles of capecitabine treatment. the primary endpoint was the incidence and grade of hand-foot syndrome (hfs) that occurred in both study arms.

Eligibility criteria:
inclusion criteria: * any adult patient starting capecitabine-containing chemotherapy * has never had capecitabine before * performance status 0-2 using the ecog classification * life expectancy more than 6 months * agreed to stop any vitamin supplements, apart from vitamin d. * liver function studies including ast/alt within 3x upper limit of normal * signed informed consent must be obtained from participating individuals
enhancing outcomes through goal assessment and generating engagement in diabetes mellitus

Conditions: Diabetes Mellitus Type 2

Summary: the purpose of this study is to evaluate whether a combination of pharmacist-delivered patient engagement techniques improves disease control and medication adherence among patients with poorly-controlled diabetes compared with usual care. these engagement techniques include shared decision-making and brief negotiated interviewing and are delivered telephonically.

the us is facing a growing epidemic of type 2 diabetes. among patients with poorly controlled diabetes, it is often not clear whether the problem is attributable to failure to appropriately intensify therapy, poor adherence to prescribed medications, unwillingness to accept new treatments or a combination of these factors. multi-component pharmacist-delivered interventions, particularly those rooted in patient engagement, have been shown to be some of the most effective at improving adherence to chronic disease medications. even though shared decision making and brief negotiated interviewing are complementary patient engagement techniques, the effectiveness of combining these 2 intervention approaches, especially in the management of diabetes, is unknown. in this study of patients using at least one oral hypoglycemic therapy with poorly controlled disease, the investigators examine the impact of a shared decision making and behavioral interviewing intervention delivered telephonically by pharmacists, compared with usual care. briefly, all patients allocated to the intervention will be mailed a patient decision aid to prime them for encounters with pharmacists. after receiving the decision aid, these patients will be asked to engage in and provide informed consent for at least 4 telephonic discussions with pharmacists about their diabetes treatment options, goals, and preferences, medication adherence, strategies for reducing adherence barriers, and the benefits of maintaining blood glucose control. the study is being conducted within a large insurer and consists of 700 patients each allocated to the intervention group and the control group. analyses will be performed on an intent-to-treat basis. after study completion, the investigators will also use predictive analytics to examine whether treatment response could be predicted based on patient characteristics, such as sociodemographic, clinical, medication use, and other motivational characteristics, which will provide information about which patients are most likely to benefit from the intervention.

Eligibility criteria:
inclusion: * commercially-insured beneficiaries * receive all medical/prescription drug benefits through horizon * on ≥1 one oral hypoglycemic agent * latest hba1c measurement ≥ 8% (within previous 6 months) * provided phone number to horizon exclusion: - currently using any insulin

Keywords: diabetes mellitus type 2
young breast cancer cohort study

Conditions: Breast Cancer

Summary: this study is prospective cohort study to investigate and identify comprehensively the clinicopathological features and long-term outcome of young breast cancer (ybc). we have enrolled breast cancer patients under 40 year-old and collected their baseline characteristics including tumor character, familiar history and other background information. moreover, we have collected breast cancer tissue/blood sample for analyzing genetic characteristics, if patient agree to genetic analysis.


Eligibility criteria:
inclusion criteria: 1. diagnosis with breast cancer 2. age under 40 year-old or diagnosis with breast cancer at pregnancy or within 1year after delivery 3. obtained informed consent form exclusion criteria: 1) cannot understand or disagree to informed consent form
study of the effect of oral zinc supplementation on superoxide radical scavengers

Conditions: Asthenozoospermia

Summary: although several studies have considered the relationship between infertility and semen super oxide radical scavengers levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on superoxide radical scavengers activity which are important in fertility of the individual has been reported.

the present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with superoxide radical scavengers activity in the seminal plasma of asthenospermic patients.

Eligibility criteria:
inclusion criteria: * the presence of asthenozoospermia in the semen sample. exclusion criteria: * the absence of endocrinopathy, varicocele, and female factor infertility. smokers and alcoholic men were excluded from the study because of their recognized high seminal ros levels and decreased antioxidant levels.

Keywords: zinc supplementation. oxidative stress. superoxide radical scavengers. asthenospermia. oxido-sensitive index.
pacesetter: program to avoid cerebrovascular events through systematic electronic tracking and tailoring of an eminent risk-factor

Conditions: Blood Pressure; Hypertension; Mhealth

Summary: program to avoid cerebrovascular events through systematic electronic tracking and tailoring of an eminent risk-factor (pacesetter) aims to assess the incorporation of its stroke intervention into 2 safety net/academic health sytems in a given us state especially burdened by stroke, thereby enhancing knowledge about the complexity of stroke interventions, and especially the nature of the challenges encountered in low resource settings and for populations traditionally underrepresented in research. altogether, the intervention, if proven implementable and effective, may eventually be exported to other medically underserved populations in the us beyond sc as a feasible model of post-stroke management.


Eligibility criteria:
inclusion criteria: * african american or non-hispanic white * history of stroke (within six months of symptom onset) * uncontrolled htn (sbp ≥ 130 mmhg at the last clinical encounter post-stroke prior to recruitment) * owning a smartphone with a data plan * able to take their own bp and self-administer medications. exclusion criteria: * any condition that would limit participation in follow up assessments including severe cognitive impairment/dementia * severe global disability (modified rankin score ≥ 3) * bmi\> 40kg/m\^2 * not being able to speak, hear, or understand english
dysfunctional lens index serves as a novel surgery decision maker for age-related cataracts

Conditions: Age-related Cataract

Summary: to study the correlations among the dysfunctional lens index (dli), lens opacities classification system iii (locs iii) nuclear opalescence grading score, preoperative corrected distance visual acuity (cdva), the objective scatter index (osi) and scheimpflug based average lens density in age-related cataracts. to investigate the potential of the dli as a novel surgery decision maker via the operating characteristic (roc) curve analysis.

each patient received a comprehensive eye examination, including corrected distance visual acuity (cdva) preoperatively and the day after surgery, subjective refraction, slit-lamp evaluation, noncontact tonometry (tx-f; cannon, tokyo, japan), and dilated fundus examination. according to the surgery decision made by the three surgeons based on the slit lamp biomicroscopy and cdva, patients were divided into two groups: surgical and non-surgical. the results of the dli, osi and average lens density (ald) were masked to the surgeons. the dli, osi, average lens density, locs iii nuclear opalescence grading, and preoperative cdva were obtained. correlations among these parameters were analyzed. roc curves were used to analyze dli values to determine a value to separate between surgical and non-surgical cataracts.

Eligibility criteria:
inclusion criteria: * patients with age-related cataracts exclusion criteria: * any corneal opacity, corneal dystrophies, retinal anomalies, a history of ocular surgery or laser treatment, a locs iii grade of cortical opacity ≥ 3.0 or posterior subcapsular cataract ≥ 2.0.
predicting pediatric pulmonary vein stenosis outcomes using data acquired during a cardiac catheterization

Conditions: Pulmonary Vein Stenosis

Summary: this is a prospective, single center study which applies a standardized, comprehensive catheterization assessment to patients with a known or suspected diagnosis of pulmonary vein stenosis (pvs) who are undergoing a cardiac catheterization at boston children's hospital. as part of the assessment, each pulmonary vein will undergo angiography (pictures using moving x-rays and contrast dye), intravascular ultrasound (ivus; pictures of the vein wall using a catheter inside the vein), pressure assessment and compliance testing. the status of each pulmonary vein will then be assessed 12 months after the catheterization (i.e. no disease, severe disease, etc.). using statistics, the investigators will determine which patient and vein characteristics (obtained at the of catheterization) can predict whether or not a pulmonary vein will have disease. the investigators hypothesize that this comprehensive, standardized, invasive assessment of pediatric intraluminal pvs can predict vein outcome.


Eligibility criteria:
inclusion criteria: * pediatric patients undergoing cardiac catheterization for the indication of known or suspicion for intraluminal pulmonary vein stenosis. exclusion criteria: * hemodynamically unstable patients as determined by the patient care team.
clinical interest of the tcpo2 technique

Conditions: Claudication

Summary: the measurement of the transcutaneous oxygen pressure records simultaneously the tcpo2 at the buttocks and chest level during walking. before and after exercise the diagnosis, investigations and treatments ongoing or to be performed are recorded. the present study focuses on the clinical interest of the transcutaneous oxygen pressure during exercise in the diagnosis of claudication in patient referred for an oximetry exercise test.

pre-test diagnostic hypothesis with probability will be completed by the physician. pre-test and post test ongoing or scheduled treatments will be completed by the physician.after the test, the same post test items will be evaluated. analysis will be done on differences of pre and post test results.

Eligibility criteria:
inclusion criteria: * referred for an oximetry exercise test * patient able to walk on a treadmill * patient covered by the french health insurance * patient able to understand the protocol * patient agrees to be involve in the protocol and sign the consent form exclusion criteria: * any heart issues during the last 3 months * pregnancy

Keywords: peripheral artery disease tcpo2 treadmill walking test intermittent claudication