Kornimate/medical-research-clean huggingface dataset:
nutritional orientations and adherence, nutritional status, clinical and life quality parameters of heart failure (hf) patients

Conditions: Nutrition; Heart Failure

Summary: the nutritional systematic orientations in outpatients with heart failure throughout 1 year in comparison to conventional treatment is estimated to lead to higher nutritional treatment adherence and improved nutritional status, clinical and life quality parameters.

to evaluate the impact of systematic nutritional orientation on adherence to diet and relation to clinical, life quality and nutritional knowledge parameters in heart failure outpatients. * to evaluate the impact of systematic nutritional orientation on nutritional status; * to evaluate the impact of nutritional systematic orientation on dietary patterns * to evaluate the impact of systematic nutritional orientation on clinical and biochemical parameters * to evaluate the impact of nutritional systematic orientation on life quality * to evaluate the impact of nutritional systematic orientation on nutritional knowledge

Eligibility criteria:
inclusion criteria: * \>= 18 years old * outpatients from the hf ambulatory (hcpa) * functional class i and ii (nyha) exclusion criteria: * outpatient who had received any orientation from a nutritionist in the last 6 months * outpatients which has not received nursing orientation in the ambulatory, * patients from other nyha class * non alphabetized

Keywords: nutritional education diet adherence nutritional knowledge life quality nutritional status impact of nutritional orientations by a systematic education program applied to outpatients with hf, in comparison to patients in a conventional treatment.
correlation of orbital cerebrospinal fluid pressure and retinal venous outflow in primary open-angle glaucoma

Conditions: Primary Open Angle Glaucoma; Normal Tension Glaucoma

Summary: a spontaneous venous pulsation over the optic disc is an ophthalmological sign that can potentially be found in up to 98% of healthy individuals. in fact, the lack of this spontaneous retinal venous pulse has been consistently implicated as an indicator of a more advanced form of certain ocular diseases, specifically open-angle glaucoma. however, the mechanisms behind these change in the retinal venous system are not clear. some evidence suggests that extraocular features such as intracranial pressure (icp) may play a role in regulating the intraocular venous outflow. the reasons for this hypothetical downstream resistance to venous outflow are not fully understood, with advances in this field being limited by our technological-imposed difficulties in assessing the structures behind the globe. however, it has been established that the volume of cerebrospinal fluid surrounding the optic nerve correlates with the icp at the orbital level. recent studies have suggested that non-invasive ultrasound-based recordings have correlated this surrogate for orbital icp with the intraocular pressure (iop) in glaucoma patients with an otherwise normal iop range (normal tension glaucoma - ntg). the investigators will therefore conduct a test to determine if this cerebrospinal volume surrounding the optic nerve correlates with the frequency of observation of an otherwise signal of venous dysfunction (i.e. the lack of a visible pulse in the retinal central vein) additionally, the investigators will assess if this correlation is different between healthy individuals, hypertensive primary-open angle glaucoma or ntg patients.

1. spontaneous venous pulsation will be recorded after a one minute fundoscopy observation. 2. b-mode ultrasound of the orbit will be performed and the optic nerve sheath diameter measured 3mm behind the globe 3. visual field examination will be performed. 4. structural examination of the optic disc (confocal microscopy) will be performed.

Eligibility criteria:
inclusion criteria: * individuals over 18 years old * willing to sign an informed consent and able to comply with the requirements of the study * having no other ocular diseases besides glaucoma exclusion criteria: * history of ocular trauma * intraocular surgery (except for cataract surgery) * eye disease (except glaucoma) * systemic diseases with ocular involvement like diabetes or graves ophthalmopathy
a new combination of evidence-based interventions to improve primary care diagnostic safety and efficiency

Conditions: Anemia; Decreased Glomerular Filtration Rate

Summary: the purpose of this study is to measure the evidence-based intervention's (ebis) impact on patient safety and efficiency, to assess the ebis implementation by measuring acceptability, appropriateness, cost, fidelity, penetration, and sustainability and to identify the facilitators and barriers that influence the degree of implementation of these ebis.


Eligibility criteria:
inclusion criteria: * new, significant abnormal anemia (hgb \>1g/dl below normal, with normal white cells and platelets) or decreased estimated glomerular filtration rate (egfr) (\<60 ml/min/1.73m2 ) seen in one of the university of texas physicians (utp) adult primary care clinics. exclusion criteria:
china rheumatoid arthritis registry of patients with chinese medicine

Conditions: Rheumatoid Arthritis

Summary: a multi-center registration study of clinical characteristics of rheumatoid arthritis (ra) patients with chinese medicine.


Eligibility criteria:
inclusion criteria: * fulfilled the rheumatoid arthritis classification criteria of 2010 american college of rheumatology (acr)/the european league against rheumatism (eular) . * aged 18 years and older. * be willing to accept cm therapies defined as chinese herbal medicine, chinese patent medicine, external treatment, acupuncture and moxibustion, etc exclusion criteria: * refuse informed consent.
registrare: a retro-prospective registry of rare primary headaches in italian tertiary headache centres

Conditions: Headache Disorders

Summary: retro-prospective survey on specific and overall prevalence and incidence of rare primary headaches (part one, chapter 3 and chapter 4, ichd-3 beta) in patients referred to italian tertiary headache centres in a 3-year (may 1, 2014-april 30, 2017 - retrospective data) and annually (from may 1, 2017 - prospective data).

we planned to collect data from may 1, 2014 and afterwards, by means of both retrospective and prospective approaches. all patients who have received or will receive a diagnosis of rare primary headache will be asked to participate and, to this aim, to give their informed consent. each participating centre should have received the approval of the competent ethics committee before commencing any study procedures. the registry will contain anagraphic information and data about diagnosis, treatment, comorbidity, and clinical features of the headache. patients' data will be coded through the italian health system unique identifier, in order to avoid duplications of patients referring to more than one centre and also to monitor multiple referrals. a web-based open source platform (surveymonkey.org) will be used to collect data.

Eligibility criteria:
inclusion criteria: * diagnosis of rare primary headaches (part one, chapter 3 and chapter 4, ichd-3 beta) * signed informed consent exclusion criteria: * none

Keywords: rare headaches epidemiology
therapeutic lifestyle modifications to reduce burden of chronic disease

Conditions: Metabolic Syndrome; Triglycerides; Blood Pressure; Diabetes

Summary: the investigators previously established that there was a high burden of disease among all categories of staff at the university of the west indies, st. augustine and in many ways, this group is typical of the working class of the caribbean population. many had poor lifestyle behaviors, 23.8% had metabolic syndrome (ms) with many having one or more ms components. since most time is spent at work, the workplace is understandably the most logical location to address issues pertaining to health, disease prevention and wellness and on-site programs have yielded many health and other benefits to employees and employers alike. onwards of the 1980s, numerous studies have been done on work-site intervention programs and these have shown that if a company is able to identify employees at risk for developing health problems and then intervene, health risks and the resulting medical problems are reduced. such a program, if tailored to meet the needs of participants, may yield similar benefits among the staff of the university of the west indies.

to conduct a randomized controlled intervention of lifestyle modifications among individuals with a high burden of metabolic syndrome components such as high body mass index, high fasting blood glucose and abnormal lipid profile. a 6-month intervention is designed for implementation to detect a 20% reduction in ms components with 90% confidence. participants (n=148) had 2 or more ms components and will be randomly assigned to intervention or control group. intervention will comprise individual diet counseling, an exercise plan and monthly lifestyle workshops. controls will receive printed material on healthy eating and lifestyle modification.

Eligibility criteria:
inclusion criteria: * having 2 or more metabolic syndrome components exclusion criteria: * having less than 2 metabolic syndrome components

Keywords: lifestyle diet exercise
geriatric determinants of curative radiotherapy scheme choice for breast cancer elderly patient treatment compliance and tolerance

Conditions: Breast Cancer

Summary: this study proposes an onco geriatric evaluation (activities of daily living, instrumental activities of daily living, mini mental state examination, mini geriatric depression scale, mini nutritional assessment, cumulative illness rating scale-geriatric, and " timed get up and go " tests) for elderly breast cancer patients. the score obtained at this evaluation will determine the radiotherapy scheme.

breast cancer is the most frequent cancer for elderly women and represents the first mortality cause for them. breast cancer incidence increases for elderly women and will become a major public health problem in the next years. the principal therapeutic solution is the partial mastectomy associated to radiotherapy. however, the radiotherapy scheme and its role are debated for elderly patients. hypo fractionated radiotherapy could be considered as an advantageous option. the treatment duration (6,5 weeks) and direct and indirect fatigue (around 33 travels) are major cons. thereby, for elderly patients, the selection of patients who will benefit from a shorter treatment could be really difficult. it would be interesting to define an objective scoring, predicting a bad or good tolerance and observance to the radiotherapy. nowadays, onco geriatric evaluations are used to decide some treatment's decision, but no study compared different orientated radiotherapy schemes. the present study proposes an onco geriatric evaluation leading to a score according to seven tests (activities of daily living, instrumental activities of daily living, mini mental state examination, mini geriatric depression scale, mini nutritional assessment, cumulative illness rating scale-geriatric, and " timed get up and go " tests). the score will then determine an adapted radiotherapy scheme.

Eligibility criteria:
inclusion criteria: * woman more than 70 years old, * patient carrying a breast cancer proven histologically and treated by radiotherapy in curative intent. exclusion criteria: * man, * patient with metastatic cancer, * patient with impossible follow-up at 6 months (planned relocation, patient support in another center), * patient under protection of justice or unable to give consent.

Keywords: breast cancer onco geriatric evaluation radiotherapy hypo fractionated radiotherapy normo fractionated radiotherapy large hypo fractionated radiotherapy
safety and pharmacokinetic characteristics after administration of hip1503 and hgp1103 in healthy male volunteers

Conditions: Overactive Bladder

Summary: the purpose of this study is to compare the safety and pharmacokinetic characteristics after administration of hip1503 and hgp1103 in healthy male volunteers.


Eligibility criteria:
inclusion criteria: 1. healthy male volunteers, age 19 to 45 years. 2. the result of body mass index(bmi) 17.5 kg/m2\~ 30.5 kg/m2, body weight over 55kg. 3. subjects who have ability to comprehend the objectives, contents of study and property of study drug before participating in trial and have willingness to sign of informed consent in writing. exclusion criteria: 1. presence of medical history or a concurrent disease, including clinically significant disorders in kidney, liver, cardiovascular system, respiratory system, endocrine system, or neuropsychiatric system. 2. medical history of gastrointestinal diseases that effects drug absorption (esophageal disease, chronic disease) or surgery( except appendectomy , herniolaparotomy) 3. sit sbp \> 140 mmhg, sit dbp \> 90 mmhg 4. alcohol or drug abuse within 1 year
does urinary timp2 and igfbp7 can identify high risk patients of progression from mild and moderate to severe acute kidney injury during septic shock?

Conditions: Acute Kidney Injury; Septic Shock

Summary: septic shock is one of the leading causes of death in patients admitted to the intensive care unit (icu). acute kidney injury (aki) occurs in almost 50% of septic patients and is associated with significant mortality. progression to the last stage (kdigo stage 3) of aki is an important step in the disease, as it usually requires initiation of rrt. renal biomarkers are unable to accurately identify those patients who will progress to severe aki (kdigo 3). however, identification of patients at risk of progression to severe aki could help the clinician to initiate optimal therapy including rrt. a new urine test, the nephrocheck™ corresponding to the product of the urinary concentrations of 2 markers of renal tubule injury (timp2 and igfbp7) has been validated. the investigator have already performed two previous studies including septic shock patients (akicheck and bioocheck). those previous datas will be reanalysed to examine whether the new urinary biomarkers timp2 and igfbp7 can predict progression within 24 hours and 72 hours from mild and moderate (kdigo 1 or 2) to severe aki (kdigo 3) in patients with septic shock. -all the datas required will be collected from two previous studies (akicheck and biocheck) performed in 3 centers: amiens medical icu, melun medico surgical icu and montpellier medical icu.


Eligibility criteria:
inclusion criteria: * age 18 or over * septic shock (according to bone's criteria) within 4 hours of introduction of catecholamines * aki, characterized by a kdigo score ≥ 1 * social security coverage exclusion criteria: * aki requiring emergency rrt (in the critical care physician's opinion). * anuria * stage 4-5 chronic kidney failure with a gfr below 30 ml/min. * rapidly progressing renal disorders (glomerulonephritis, hus, blockage, etc.) * obstructive aki * probable glomerular damage (nephritic syndrome, nephrotic syndrome, chronic glomerulonephritis) * pregnancy or breastfeeding * legal guardianship or lack of social security coverage. * cardiocirculatory arrest * life expectancy \<48 hours. * child c cirrhosis * prior occurrence of aki during the current hospital stay * transplantation * subject participating in another study with an exclusion period ongoing at the time of the pre-inclusion
the io-flex® study: evaluation of the baxano io-flex® system for decompressive lumbar surgery

Conditions: Lumbar Spinal Stenosis

Summary: the purpose of this study is to evaluate the clinical performance of the io-flex® system in reducing pain and symptom severity in patients with one or two level lumbar spinal stenosis that requires surgery.


Eligibility criteria:
inclusion criteria candidates for this study must meet all of the following criteria: 1. age ≥18 years 2. leg/buttock pain with or without back pain 3. failed nonoperative medical management 4. a minimum leg pain score of 4.0 cm on the visual analogue scale (vas) 5. clinical/radiographic diagnosis of lss in the l2-l3 to l5-s1 region 6. able and willing to give voluntary, written informed consent to participate in this clinical study exclusion criteria candidates will be excluded from the evaluation if any of the following apply: 1. back pain only 2. a diagnosis of central stenosis only 3. more than two levels requiring decompression 4. fixed motor deficit 5. significant instability of the lumbar spine as defined by ≥ 4mm translation between standing flexion and extension lumbar spine plain film radiographs 6. sustained pathologic fractures of the vertebrae or multiple fractures of the vertebrae and/or hips 7. primary disc pathology and/or patients who will undergo a discectomy 8. prior surgery of the lumbar spine at the level(s) of planned treatment 9. spondylolisthesis or degenerative spondylolisthesis greater than grade 1 (on a scale of 1 to 4) 10. spondylolysis (pars fracture) at any level in the lumbar spine 11. degenerative lumbar scoliosis with a cobb angle greater than or equal to 25° 12. symptomatic vascular claudication in the lower extremities 13. cauda equina syndrome (neural compression causing neurogenic bowel or bladder dysfunction) 14. evidence of active (systemic or local) infection at time of surgery 15. paget's disease at involved segment or metastasis to the vertebra, osteomalacia, or other metabolic bone disease 16. tumor in the spine or a malignant tumor except for basal cell carcinoma 17. prisoner or transient 18. recent history of known narcotic abuse 19. any significant psychological disturbance past or present, psychotic or neurotic, that could impair the consent process or ability to complete subject self-report questionnaires 20. involved in pending litigation of the spine or worker's compensation related to the back 21. inability to communicate clearly in the english language 22. morbid obesity (bmi \> 40) 23. plans to relocate within the next 2 years 24. pregnant or planning to become pregnant 25. irreversible coagulopathy or bleeding disorder a. subjects on coumadin or other anticoagulants may participate. investigators should follow routine practices for perioperative discontinuation and reinitiation of anticoagulants. 26. subject unwilling to undergo blood transfusion, if necessary

Keywords: lumbar spinal stenosis decompression lumbar spinal decompression lumbar spinal decompressive surgery
antiangiogenic therapy with bevacizumab in retinopathy of prematurity. structural outcome

Conditions: Retinopathy of Prematurity

Summary: purpose:retinopathy of prematurity (rop) continues tobe a major cause of blindness in children. although ablation of the retina with laser or cryotherapy reduces the incidence of blindness by suppressing the neovascular phase of rop the visual outcomes after treatment are often poor. vascular endothelial growth factor(vegf) has an important role in the pathogenesis of rop and inhibition of vegf expression in the neovascular phase might prevent destructive neovascularization in rop. the aim of this study is to determine the safety and efficacy of intravitreal bevacizumab in the treatment of retinopathy of prematurity


Eligibility criteria:
inclusion criteria: * retinopathy of prematurity stages iii, iv and v in which we can not treat with laser o cryotherapy exclusion criteria: * patients that could be treated with cryotherapy or laser

Keywords: retinopathy of prematurity antiangiogenic therapy
improvement of sleep quality by repneu® coils in advanced pulmonary emphysema

Conditions: COPD; Emphysema

Summary: improvement of sleep quality in emphysema patients is desirable. yet, there are no data of patients treated with repneu coils. this monocenter prospective study investigates the effect on sleep quality of repneu coils for reduction of dynamic hyperinflation in advanced disease stages of pulmonary emphysema. patient's sleep will be studied in three polysomnography measurement nights, one prior to coil treatment, one six months after, and one twelve month after. primary objective is to investigate differences in sleep quality 6 and 12 months after coil treatment. further endpoints are changes in daily activity and sleep (actigraphy), 6mwt, lung function parameters, and questionnaires (sgrq, mmrc dyspnoe scale).


Eligibility criteria:
inclusion criteria: * written consent * repneu coil treatment according to clinical criteria exclusion criteria: * pregnancy or nursing period * participation in another clinical trial within the last 4 weeks * incapable of giving consent * known osa (ahi\>10)

Keywords: sleep emphysema coils lung volume reduction
a study on the efficacy and safety of benzonatate soft capsules for improving adult cough symptoms

Conditions: Cough

Summary: the purpose of this study is evaluate the efficay and safety of benzonatate soft capsules for improving adult cough symtoms.

the purpose of this study is evaluate the efficay and safety of benzonatate soft capsules for improving adult cough symtoms. the study was designed to be randomized, double-blind, placebo-controlled.subjects were randomly assigned to the benzonatate soft capsule group and the placebo group on a 1:1 basis。according to the regulatory requirements, 200 cases were planned to be included. considering that poor efficacy of the placebo control group might lead to shedding, a 10% increase in shedding was achieved, and 220 cases were finally determined, with 110 cases in each group.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 75 years of age; 2. the onset time is more than 3 days and less than 8 weeks; 3. dry cough, the total score of cough symptom in day and night is greater than 4; 4. willing to sign informed consent. exclusion criteria: 1. allergic person or known to the test drug containing ingredients (including benzo, soybean oil, glycerin, gelatin) allergy; 2. the cough symptoms are caused by bronchial asthma, tuberculosis, pneumoconiosis, bronchiectasis, tumor and other diseases that have been clearly diagnosed. 3. coughers caused by drugs; 4. respiratory depression or airway obstruction; 5. patients with uncontrolled diabetes or hypertension; 6. having difficulty in swallowing or affecting drug absorption, such as active peptic ulcer and acute gastritis; 7. patients with severe hematopoietic system, nervous system, mental illness (including alcohol and substance abuse) or immunodeficiency diseases; 8. laboratory examination results are abnormal with clinical significance, among which: a.c r is higher than normal value; b.a lt and/or ast\>2 times normal value upper limit (uln). 9. women during pregnancy or lactation or women who are preparing for pregnancy or lactation during the trial; 10. in the first 3 months of screening, any other experimental drug treatment was accepted; 11. failure to comply with test plans or other conditions that other researchers believe is not appropriate for the group.