Kornimate/medical-research-clean huggingface dataset:
the efficacy of different types of stretching on range of motion, pain and function in elbow limitation

Conditions: Postoperative Pain; Elbow Fracture; Stiffness of Elbow, Not Elsewhere Classified

Summary: the aim of the study is to compare the efficacy of proprioceptive neuromuscular facilitation (pnf) stretching and static stretching on range of motion (rom), pain and function in elbow limitation.

to compare the efficacy of pnf stretching and static stretching on rom, pain and function in elbow limitation, forty voluntary patients with elbow limitation, aged between 18-55 years will be randomly divided into two groups: pnf stretching group and static stretching group. pnf stretching will be combined with exercise and cold application in pnf stretching group, static stretching will be combined with exercise and cold application in static stretching group, will be applied for 12 sessions. the patients will be assessed before and after six-week treatment. the pain on activity, at rest and at night will be assessed with visual analog scale (vas). rom will be assesed with universal goniometer. the functional status will be evaluated by disabilities arm, shoulder and hand (dash). kinesiophobia and quality of life will be assessed with tampa scale for kinesiophobia and short form-12, respectively. the global rating of change will be used to evaluate patient satisfaction.

Eligibility criteria:
inclusion criteria: subjectswill be included with * aged between 18 and 65 years * elbow fracture in the six months before the study * elbow limitation in flexion or extension * being volunteer to participate * fractures should be managed with conservatively or surgically exclusion criteria: * malunion or nonunion fracture * occurrence of complex regional pain syndrome, peripheric nerve injury, heterotopic ossification, myositis ossification or post-traumatic ankylosing * non-healing wound or infection * previously received physiotherapy for elbow limitation * having any cardiovascular diseases, neurological disorders, rheumatic diseases or psychiatric diseases * could not adjust to treatment

Keywords: pain exercise proprioceptive neuromuscular facilitation stretching static stretching
effectiveness of ultrasound for local fat treatment

Conditions: Fat Burn

Summary: it's evident that the literature shows good results on the use of aesthetic ultrasound in the treatment of localized fat, however, little has been explored so far, about possible psychological influences of this method and therefore, it is believed that it is pertinent to elaborate studies that include a placebo group, in order to measure the real effects from the exclusive application of ultrasound. therefore, the objective of this study will be to verify the influence of the application of aesthetic ultrasound in the treatment of localized fat, using for both clinical, biochemical and functional parameters.

there will be included 30 participants, female gender, communities between 18 and 30 years, apparently saudi, local abdominal fat, located in three groups: control (n = 10), experimental (n = 10) and placebo (n = 10) . or group control não recebeu nenhum type of intervention. no experimental group, 10 sessões de ultrassom (skinner brand, são paulo) will be carried out in the previous region for 20 minutes. no placebo group will be applied ultrassom (skinner brand, são paulo), pormem com zerada intensities. anthropometric avaliação e of dobras cutâneas will be carried out at this time before applying the treatment protocol. as skin folds will be measured by means of adipometers.

Eligibility criteria:
inclusion criteria: * additional inclusion criteria included body mass index (bmi) equal to or less than 25.0 kg / m2 * adipose tissue thickness 2.6 cm or more in the treatment region; * preserved elasticity and local tissue integrity; * in addition, participants had to agree not to change their daily routines during the study. exclusion criteria: * pregnancy. * breastfeeding; * history of liposuction; * lipolysis by injection therapy; * abdominoplasty or surgery in the treatment region; * weight reduction medication; * recent surgery in the last 12 months; * implantable electrical device; * neurosurgical deviation; * hernia; * sensory loss or dysesthesia in the treatment region; * cancer; * circulation problems; * or chronic systemic disease such as diabetes or metabolic syndrome.
blood pressure after preeclampsia/hellp by self monitoring study

Conditions: Preeclampsia; Cardiovascular Risk Factor; Cardiovascular Diseases; Hypertension

Summary: rationale: women with a previous history of preeclampsia (pe)/hellp have a twofold higher risk of cardiovascular disease (cvd) and a fourfold increased risk to develop hypertension at a relative young age. in the latest 2016 esc guidelines 'cvd prevention', previous pe has been acknowledged as a serious cvd risk factor in women. in clinical practice, however, these women are still underappreciated for their cvd risk. it has not been established yet how adequate lifelong prevention in these potentially high risk women can optimally be achieved from their childbearing years onwards. objective: to evaluate feasibility, usability, acceptance and potential obstacles of blood pressure (bp) home monitoring in high-risk women, aged 40-60 years, after a previous pe in pregnancy. in addition to evaluate the effectiveness of bp home monitoring on the occurrence of hypertension, the efficacy of bp treatment, quality of life (qol), health-related symptoms, work ability and life-style behaviour. study design: randomized, open label feasibility study to compare ehealth guided self management of bp monitoring and lifestyle advice with 'usual care'. study population: approximately 200 women, aged ≥ 40 and ≤ 60 years, with a previous pe in pregnancy will be invited to participate (both early and late pe). patients will be recruited from the departments of obstetrics/gynaecology in 6 centres in the euregio rhein-waal and from the department of cardiology radboudumc. intervention: ehealth guided measurements of bp at regular intervals and recurrent lifestyle advice (intervention-group) will be compared with "usual care". primary outcome: feasibility, usability, acceptance and potential obstacles of bp home monitoring in high-risk women after a previous pe in pregnancy at 1 year of follow-up.


Eligibility criteria:
inclusion criteria: * previous preeclampsia/hellp syndrome, defined as diastolic bp≥90 mmhg with proteinuria ≥ 0.3gram/24 h, during one or more pregnancies, more than 1 year ago. * 'early' or 'late' pe/hellp * age ≥40 and ≤ 60 years exclusion criteria: * pregnant women or women wishing for future pregnancie(s) * inability to perform self bp measurements * not having a smartphone (apple or android) * already having regular hypertension control by gp or medical specialist * previous cardiovascular events, such as myocardial infarction , stroke, heart failure and symptomatic ischemic heart disease

Keywords: patient empowerment women's health home blood pressure monitoring
acupuncture to reduce anxiety in alzheimer's disease (ad) and ad related dementias

Conditions: Alzheimer's Dementia With Behavioral Disturbance

Summary: the purpose of this study is to investigate the influence of acupuncture on heart rate variability, skin conductance (sweating), and rated behavioral expression of agitation, irritability, and anxiety and mood in qualifying adults with a diagnosis of cognitively unimpaired, or probable alzheimer's disease, frontotemporal dementia or dementia with lewy bodies. study subjects will all receive one real acupuncture treatment; mood scales will be assessed before and after. massachusetts general hospital is paying for this research to be done.

acupuncture is a system of integrative medicine that involves pricking the skin or tissues with needles, used to alleviate pain and to treat various physical, mental, and emotional conditions. originating in ancient china, acupuncture is now widely practiced globally.

Eligibility criteria:
inclusion criteria: * ages 55-95 inclusive, male or female. * diagnosis of cu, or probable ad, ftd or dlb as determined by established clinical criteria at screening14. * for the aia symptomatic groups, a score of \> 2 for severity on at least 1 of the aia-relevant items on the npi-q, i.e., anxiety, irritability/lability, agitation or aggression. * for the cu and no neuropsychiatric symptoms group, npi-q score must be 0 for aia-relevant items, i.e., anxiety, irritability/lability, agitation or aggression. * no concurrent use of therapies with prohibitive effects on interpretation of hrv and sc measurements, e.g., those with major direct adrenergic or anticholinergic activities. * stable doses (\>2 weeks) of concurrent dementia or psychiatric drugs for those applicable. exclusion criteria: * atrial or junctional arrhythmias or other cardiac conditions, including pacemakers or other implantable devices that affect rr intervals or their measurement. * aia symptoms or dementia so severe that subject cannot assent and cooperate with all study procedures or requires immediate rescue medication for behavioral control. * seizure disorders or other potentially confounding medical, neurological or longstanding psychiatric illnesses.
investigating multigene methylation dynamics in treatment response surveillance for intestinal carcinoma

Conditions: Intestinal Cancer

Summary: the primary objective is to determine whether pretreatment-to-posttreatment changes in circulating multigene methylation levels correlate with objective response rates (orr) assessed by contrast-enhanced ct/mri and levels of serum tumor markers. secondary endpoints include: (a) time-dependent association between methylation fluctuation patterns and progression-free survival (pfs), (b) comparative diagnostic accuracy of methylation indices versus conventional biomarkers, and (c) feasibility of using methylation thresholds to guide adaptive therapy modification.


Eligibility criteria:
inclusion criteria: age at initial diagnosis: 18-75 years histologically confirmed colorectal or small intestinal malignancy, with complete medical records, confirmed pathological diagnosis, and definitive staging data (tnm staging system) no history of other primary malignancies absence of distant metastases (liver, lung, or other sites) confirmed by imaging examination (ct/mri) no prior surgical resection, chemotherapy, or pd-1/pd-l1 immunotherapy before enrollment availability of complete biospecimen information, including: sample id (medical record number), demographic data (sex, age), clinical diagnostic data, tumor marker profiles (cea, ca19-9, etc.) exclusion criteria: life expectancy \<6 months (as assessed by ecog score ≥4 or palliative performance scale ≤30%) cognitive/psychiatric conditions: a. legally incapacitated individuals without legal guardians, b. active psychotic disorders (e.g., schizophrenia, bipolar disorder) or dementia (mmse score \<24) investigator-determined exclusions
decision support workshop for breast reconstruction

Conditions: Breast Cancer

Summary: the purpose of this study is to determine the effectiveness of a pre-consultation decision support workshop for breast reconstruction after breast cancer, in facilitating the decision-making process, compared to routine pre-surgical education.

postmastectomy breast reconstruction is becoming increasingly utilized in breast cancer patients to provide surgical restoration of the breast mounds. the breast reconstruction discussions can be highly complex, as there are many different techniques, timing, and complications that are unique to each procedure. however ¼ of women report being dissatisfied with some component of their cancer or reconstructive care. failure of the physician to provide adequate information about treatment options is the most frequent source of cancer patient dissatisfaction and breast reconstruction patients have expressed a need for further information regarding the complex decision to pursue breast reconstruction. in such scenarios of complex medical decision-making, decision support techniques may be an effective solution to information provision and shared decision-making. as a result, the investigators developed a pre-consultation educational group intervention delivered in a group setting for women considering breast reconstruction, with the aims to fill an existing information-gap, promote high-quality decision-making and enhance decision self-efficacy and other decision measures. this pilot study will be the first step in the evaluation of the educational group intervention and the results will be used to determine the feasibility and inform the optimal design for a definitive randomized controlled trial. this study will first examine the feasibility and acceptability of the intervention through implementation in a pilot, mixed-methods, 1:1 allocation parallel-arm randomized controlled trial.

Eligibility criteria:
inclusion criteria: * patient age: 18 - 79 years at the time of consultation * in situ or invasive biopsy confirmed breast adenocarcinoma * considered for immediate or delayed breast reconstruction * first consultation for breast reconstruction exclusion criteria: * chest wall or atypical breast malignancy (ex: angiosarcoma) or inflammatory adenocarcinoma of the breast * completion any phase of reconstruction, or for revision reconstruction * patient cannot read or write in english. * cognitive impairment or uncontrolled psychiatric diagnosis

Keywords: breast cancer breast reconstruction shared decision making decision support intervention
assessment of spontaneous baroreflex sensitivity in carriers of implantable cardioverter defibrillators: association with disorders of the ventricular heart rate. case-control study

Conditions: Myocardial Infarction

Summary: we must implement 8 implantable cardioverter defibrillators (icds) to save a life in 3 years after myocardial infarction (mi) in primary prevention. left ventricular ejection fraction (lvef) is proposed as the one tool predicting sudden cardiac death after mi. several studies have shown that impairment of spontaneous baroreflex sensitivity (brs) after mi was predictor of sudden death.


Eligibility criteria:
inclusion criteria: * patients implanted with an implantable cardioverter defibrillator for primary prevention of of cardiac sudden death, ischaemic cardiomyopathy * implantable cardioverter defibrillators implantation for at least 3 years * age ≥ 18 years exclusion criteria: * ventricular or atrial pacing ≥1%, * atrial fibrillation history * age under 18 years
cd155 in bladder cancer

Conditions: Bladder Cancer

Summary: this research is designed to investigate the prognostic and predictive value of cd155 in muscle invasive bladder cancer.


Eligibility criteria:
inclusion criteria: * patients with non-metastatic muscle invasive bladder cancer * pathology confirmed urothelial carcinoma * underwent cystectomy and pelvic lymph node dissection exclusion criteria: * not enough tissue for immunohistochemistry * patients with a second neoplasm
dance and diabetes/prediabetes self-management

Conditions: Diabetes; Pre Diabetes

Summary: the dance for diabetes program was designed as a community service project for the north carolina albert schweitzer fellowship. the purpose of this research is to evaluate the effectiveness of the project and its impact on participants. this study will assess whether a group dance workshop along with diabetes education can help people with diabetes and prediabetes.

this is a pilot study that will be testing whether or not a group dance workshop is useful and effective. if it is, the study team will refine the workshop model and do additional dance classes in the future. this research study will involve attending a dance workshop once a week for 2 months using an online, video-conferencing computer application. participants will also receive information about exercise and how to manage their diabetes. participants will receive a phone call every week during the 2 months to assess their experience. study participants will also be asked to complete surveys at the beginning and end of the 2-month session, as well as 1 month and 2 months after the classes end.

Eligibility criteria:
inclusion criteria: * adults proficient in english with diabetes or prediabetes * subjects who have an established healthcare provider exclusion criteria: * known cardiovascular disease (acute coronary syndrome, stable or unstable angina, coronary or other arterial revascularization, stroke, transient ischemic attack, and peripheral arterial disease) for the last 6 months * unwilling or unable to partake in light to moderate level of dance physical activity for 1 hour because of physical impairment (e.g. wheelchair, amputation)

Keywords: dance reduce blood sugar prevention
post-market surveillance with a novel mhealth platform

Conditions: Gastrectomy; Atrial Fibrillation

Summary: this is a study to pilot the feasibility of using a novel patient-led, smartphone-based mobile health platform (hugo) for real-world surveillance of outcomes of patients after they undergo a bariatric surgical procedure (either sleeve gastrectomy or gastric bypass) and catheter-based atrial fibrillation ablation

the plan is to pilot test a novel patient-led, smartphone-based mobile health platform (called hugo) for real-world surveillance of outcomes in 60 total patients after medical device use. research associates will be recruiting patients before they undergo a bariatric surgical procedure (either sleeve gastrectomy or gastric bypass) and catheter-based atrial fibrillation ablation. patients will then be queried about specific symptoms related to their procedure. patients will also be given syncable devices to use that will provide additional insights into their health and health outcomes. this pilot project will engage patients to report outcomes while also synchronizing data from their electronic health records and pharmacy accounts to ascertain the ability of emerging mobile health technologies to aid in post-marketing surveillance.

Eligibility criteria:
inclusion criteria: * age \>18 * english-speaking * planned for either a bariatric surgical procedure (either sleeve gastrectomy or gastric bypass) or catheter-based atrial fibrillation ablation * participant is willing and able to read and sign consent and participate in study * participant has an email account and a mobile device (smartphone or tablet) able to download the necessary applications * participant is willing to use the mobile health platform and syncable devices (e.g. fitbit charge 2) * attending bariatric surgeon or electrophysiologist (as appropriate) concurs that patient is a candidate for enrollment exclusion criteria: healthy patients patients who refuse participation
visual performance with a hydrophobic aspheric monofocal iol

Conditions: Cataract

Summary: artificial lenses, otherwise known as intraocular lenses (iols), are used to replace the natural crystalline lens within the eye during cataract or refractive lens surgery. monofocal iols are the traditional iol type used during cataract surgery. these monofocal iols provide excellent distance vision, however spectacles are required for reading and intermediate distance tasks. monofocal intraocular lenses are the mainstay of cataract surgery, but with advancing technologies and a wider selection of lenses available, demand for improved outcomes, improved lens design and ease of surgical implantation have increased. the purpose of this study is to assess the visual performance of the eyecee one monofocal intraocular lens. in addition an assessment of the ease of insertion by the surgeon will be quantified.

artificial lenses, otherwise known as intraocular lenses (iols), are used to replace the natural crystalline lens within the eye during cataract or refractive lens surgery. monofocal iols are the traditional iol type used during cataract surgery. these monofocal iols provide excellent distance vision, however spectacles are required for reading and intermediate distance tasks. there are many different designs of monofocal iols, all with their own unique optical properties, however there is little evidence to support which optical design provides the best visual outcome. this research project allows us to assess the visual outcomes of a specific monofocal iol. it also allows us to assess the ease of use of the lens to the surgeon. each subject will be evaluated at two visits following iol implantation; visit 1 (1 month post implantation), visit 2 (3 months post implantation). at both post-operative visits the patient will undergo: refraction uncorrected and best corrected distance and near visual acuity measurement optical biometry to assess elp slit lamp biomicroscopy to assess for post-operative complications at the time of surgery, the ophthalmic surgeon will complete a questionnaire, detailing lens insertion time and ease of use.

Eligibility criteria:
inclusion criteria: -clinically significant cataract requiring cataract surgery exclusion criteria: * amblyopia * corneal astigmatism of \>1.00d * dilated pupil size smaller than 5mm * macular pathology * glaucoma * retinal disease * corneal disease * abnormal iris * pupil deformation * any previous corneal or intraocular surgery * any patient who had surgical complications will also be excluded from participation in the study.
efficacy of oral apremilast in the treatment of alopecia areata at the tertiary care hospital, karachi.

Conditions: Alopecia Areata

Summary: alopecia areata (aa) is a disease characterized by hair cycle dysfunction and the presence of peribulbar and perifollicular mononuclear cell infiltrate.1 the majority of patients report the rapid onset of one or several well-defined, usually round, 1 to 4 cm areas of scalp hair loss. a common feature is the presence of "exclamation-mark" hairs that are broken and short hairs that taper proximally. commonly used treatment modalities are steroids (intra-lesional, topical or systemic), contact immunotherapy, anthraline, minoxidil, calcineurine inhibitors, topical retinoids, systemic immune modulating agents, photo-chemotherapy, dermatography wigs and hypnotherapy etc apremilast is a newer drug. it is an oral small-molecule inhibitor of phosphodiesterase 4 (pde4), this may be effective treatment for a variety of inflammatory skin disorders such as alopecia areata.

due to its increasing prevalence and lack of local data on its long term management, the investigators designed current study on efficacy of oral apremilast in alopecia areata in-order to evaluate its effectiveness.

Eligibility criteria:
inclusion criteria: * either gender. * age 20-70 years. exclusion criteria: * patients with history of connective tissue disorder, vasculitis, seropositive and seronegative arthritis * patients with history of psoriasis. * patients excluded from the study will be patients having history of previous treatments with some systemic agents