Kornimate/medical-research-clean huggingface dataset:
cognitive-motor exercise for stroke patients in function, cognition and related brain changes.

Conditions: Stroke

Summary: the purpose of this study is to evaluate a cognitive-motor exercise on dual-task interference during dual-task ankle movement and the corresponding alterations of brain activity.

the prevalence rate of stroke increased by 106.0% (93.7-118.8) from 1990 to 2019 in china, and stroke burden is still severe. community ambulation is an important factor that influences health-related quality of life after a stroke.in daily living, effective community ambulation requires the ability to maintain balance and walking function while engaging in other tasks that demand attentional resources simultaneously (i.e., dual-tasking). increasing evidence has shown that stroke patients have more problems with dual-task balance and walking function than their age-matched able-bodied peers. stroke individuals were found to have more reduction in both the walking speed and cognitive recall than control group during walking with remembering a shopping list. hence, since stroke victims must reintegrate into community, this kind of cognitive-motor interference needs to be thoroughly studied.

Eligibility criteria:
inclusion criteria clinical diagnosis of stroke, stroke onset of more than 6 months aged 50 or more capable of following verbal instructions having a montreal cognitive assessment score≥22, able to walk for 1 minute without physical assistance not receiving any formal rehabilitation training having a fugl-meyer ankle dorsiflexion-standing position score≥1 exclusion criteria contraindications to exercise (e.g., unstable angina) contraindications to mri (e.g., pacemaker) color blindness neurological disorders gait-precluding pain comorbidity

Keywords: dual-task training cognitive-motor interference
arthrocentesis and temporomandibular joint disorders a conservative alternative to surgical treatments

Conditions: TMJ Internal Derangement

Summary: this study aims to evaluate the efficacy of arthrocentesis in the treatment of internal derangement of the temporomandibular joint (tmj).

this work was designed as a prospective case series clinical study. patients imaging was evaluated with cone-beam computed tomography and nuclear magnetic resonance at the beginning of the treatment and after the last arthrocentesis.

Eligibility criteria:
inclusion criteria: * tmj pain * tmj noises and click * history of unsuccessful conservative management (nsaid and occlusal bite) * occlusal bite still present exclusion criteria: * degenerative joint disease (such as osteoarthritis, rheumatoid arthritis etc.) * history of condylar fractures or previous tmj trauma * tmj surgery

Keywords: tmj arthrocentesis internal derangement conservative treatment
allogeneic adipose derived stem cells for werdnig hoffman patients

Conditions: Infantile Spinal Muscular Atrophy, Type I [Werdnig- Hoffman]

Summary: spinal muscular atrophy (sma) is an autosomal recessive disease of motor neurons. in the early 1980s, werdnig from vienna university and hoffman from heidelberg university described this disorder. so sma type 1 was named werdnig- hoffman disease. this is the first genetic disorder that cause death after cystic fibrosis in infants with the prevalence of 1 in 6000 birth. mutation in the smn1 gene (survival motor neuron) is the reason for the disease that cause decrease in the smn protein production. so the alpha motor neurons in the spinal cord ventricle horn will be destroyed and it cause progressive paralysis and defenite death.no specific therapy is yet available for the treatment of werdnig-hoffmann disease. treatment is not disease-modifying and just is supportive. sma type 1 is diagnosed within the early 6 month after birth and accompanied with breath disorders and definite death in 2 years. the affected infants have a weak muscle tone and they couldn't even hold their head up. perhaps the only open way for these patients is the application of stem cells that could deliver trophic factor to the apoptotic cells. so this study focuses on the effectivness of cell therapy via adipose derived mesenchymal stem cells on the probable phenotypic changes in these patients.


Eligibility criteria:
inclusion criteria: age under 12 month, weak muscle tone, weakness in mobility, patients sitting without full conduction of nerve existence of home senses, normal brain function exclusion criteria: age beyound 12 month, brain abnormality, loss of sensory functions malignancies
adjuvant chemotherapy with paclitaxel and cisplatin in lymph node-positive thoracic esophageal squamous cell carcinoma

Conditions: Esophageal Cancer

Summary: esophageal cancer is a highly aggressive malignancy with a poor overall outcome. * five year survival rate after radical esophagectomy is modest at about 40%.the patients with regional lymph node metastases have worse outcome than those without lymph node metastases. * no standard postoperative adjuvant chemotherapy has ever been established.


Eligibility criteria:
inclusion criteria: * ability to give informed consent * histological proof of thoracic esophageal squamous cell carcinoma with negative proximal and distal margins * node-positive and pathologic stage m0 . * eastern cooperative oncology group (ecog) performance status 0-1 * patients were enrolled 4 to 10 weeks after surgery. * adequate organ function was required in 2 weeks of registration and was defined as: serum creatinine within normal institutional limit, and creatinine clearance (crcl) ≥60ml/minute. aspartate aminotransferase and bilirubin\<2 times of upper normal institutional limits. exclusion criteria: * prior chemotherapy or concurrent radiation therapy before esophagectomy * r1 or r2 resection * clinically significant hearing loss or symptomatic peripheral neuropathy during initial examination

Keywords: esophageal cancer adjuvant chemotherapy esophageal surgery paclitaxel cisplatin
cyp2c19 gene alteration and thienopyridine resistance in percutaneous coronary intervention study

Conditions: Stable Angina

Summary: dual antiplatelet therapy with aspirin and thienopyridines decreases the rate of stent thrombosis in patients undergoing percutaneous coronary intervention (pci). however, despite intensified antiplatelet treatment, some of the patients undergoing pci develop thrombotic stent occlusion, suggesting incomplete platelet inhibition due to thienopyridine resistance. the present study is designed in order to clarify the influence of cyp2c19 genetic polymorphism on the several biomarkers for platelet activation in japanese patients treated with thienopyridines undergoing elective pci.

we enrolled patients with stable effort angina who received dual-antiplatelet therapy with both aspirin (100mg) and clopidogrel (75mg). we performed pci 12-24 hours after 300mg loading dose of clopidogrel, or at least 7 days of 75mg clopidogrel treatment after 300mg initial loading dose. we examined platelet adhesiveness, plasma biomarkers for platelet activation such as plasma vwf and adamts13, cd40l, p-selectin levels, and adp-induced platelet aggregation using light transmittance aggregometry (lta) and verifynow p2y12 assay system in those patients. we also analyzed the cyp2c19 genetic polymorphism to examine the influence of this genetic variation on the several biomarkers for platelet activation.

Eligibility criteria:
inclusion criteria: * the stable effort angina patients * more than 20 years old * undergoing elective pci treated with aspirin and clopidogrel exclusion criteria: * patients treated with the following medical therapy (ie. warfarin, steroid, thrombolytic drug, ticlopidine, sarpogrelate hydrochloride or cilostazol) * patients with the following diseases (deep vein thrombosis, atrial fibrillation, collagen disease, infection, liver or renal dysfunction, malignant diseases)

Keywords: thienopyridine resistance stable effort angina platelet activation adamts13 von willebrand factor
active surveillance of papillary thyroid microcarcinoma

Conditions: Thyroid Cancer, Papillary

Summary: papillary thyroid microcarcinoma are small thyroid cancer measuring 1cm or less. most of this tumor are not palpable and are identified either through pathologic examination or from imaging modalities, such as ct scan or thyroid sono. active surveillance of papillary microcarcinoma is to observe thyroid papillary cancer without immediate surgical approach. the purpose of this study is to understand more about the characteristics of papillary microcarcinoma, which has been known for "the cancer slowly progression"


Eligibility criteria:
inclusion criteria: 1. \< 1 cm solitary nodule 2. surrounded by ≥ 2 mm normal thyroid parenchyma 3. subcapsular locations not adjacent to surrounding structures, recurrent laryngeal nerve, trachea, or carotid artery 4. no evidence of invasion to surrounding structures, recurrent laryngeal nerve, trachea or carotid artery 5. no extrathyroidal extension 6. clinically n0 and clinically m0 7. ≥ 18 years 8. combined severe comorbidities or inoperable condition (optional) 9. no wish to surgery and willingness to accept active surveillance 10. no history of radiotherapy on head and neck area 11. accepted by the board of thyroid cancer meeting exclusion criteria: 1. ≥ 1 cm nodule and multifocal nodules regardless of size 2. papillary thyroid carcinoma variants associated with poor prognosis (tall cell variant, columnar variant, hobnail variant) or other types of thyroid cancer) 3. subcapsular locations adjacent to surrounding structures, recurrent laryngeal nerve, trachea or carotid artery 4. evidence of invasion to surrounding structures, recurrent laryngeal nerve, trachea or carotid artery 5. extrathyroidal extension 6. any of n1 or m1 7. documented increase in size according to america thyroid association (ata) guideline in a previously confirmed papillary thyroid microcarcinoma 8. \< 18 years 9. not willing to accept observational active surveillance approach
evaluation of generalization paradigm patterns among different psychiatric disorders

Conditions: MDD; Bipolar Disorder; Schizophrenia Disorder; Anxiety Disorder (Panic Disorder or GAD); PTSD

Summary: learning includes the ability to generalize to new situations and respond to similar, yet not identical stimuli. in previous work, focused on stimulus generalization in healthy volunteers, tones that were negatively reinforced induce wider generalization curves than tones that were positively reinforced, and these in turn induce wider curves than neutral memory (schechtman et al, 2010). the current study aimed to evaluate those patterns in different clinical disorders (including schizophrenia, bipolar disorder, mdd, anxiety disorders (panic and gad) and ptsd, and healthy subjects that would be used as a control), with consideration whether those patterns are unique to any specific disorder or state. the generalization patterns evaluation would conduct twice though enable to compare the stability of those patterns during the course of the illness (i.e during remission compared to acute state). the basic paradigm based on conditioning of a tone (sound) with unpleasant noise, and extinction of that conditioning afterword. during the 60 minutes of evaluation, the capability to discriminate between the original tone and similar but not identical tones, and the tendency to categorize similar tones as identical to the original tone. a neutral tone without conditioning will be used as reference. the clinical diagnosis will conduct by a senior psychiatrist, and the state would be evaluated using standard questionnaires


Eligibility criteria:
inclusion criteria: * men and women 20-65 years of age. * primary dsm-iv diagnosis of schizophrenia, schizoaffective, bipolar (1 or 2) , major depressive disorder , generalized anxiety disorder, panic disorder, post traumatic stress disorder based on scid and confirmed by a senior psychiatrist, or subjects without axis i or ii diagnosis (control group). * capable and willing to provide informed consent. in any case when there is doubt about the patients' capacity to sign an informed consent, an independent doctor will assess the patient capacities to make treatment decisions with the clinical tool maccat-t. * able to adhere to the evaluation schedule. * able to read, hear, write and speak hebrew. * has signed a written informed consent to participate in the study. exclusion criteria: * patients with acute, unstable, significant, or untreated medical illness besides schizophrenia, anxiety disorder or affective disorder, including alcohol and drug dependence. * subjects with significant cognitive impairment including dementia, history of head injury, mental retardation, or any other cause to "organic" cognitive impairment. * current suicidal ideation or history of a suicide attempt in the past six month * subjects who were under compulsory hospitalization. * subjects with any other dominant axis i or ii diagnosis mainly anxiety disorders, which might interfere with the evaluation of the above disorders.
effects of metformin on low back pain

Conditions: Low Back Pain

Summary: the purpose of the current study is to determine the effects of metformin in non-diabetic patients with low back pain, and identify novel targets for future treatments

outcome measures were updated after the initial submission to clinicaltrials.gov. the outcomes were changed in the institutional review board protocol but not updated on clinicaltrials.gov. these outcome measures have since been updated to reflect what was collected for the trial.

Eligibility criteria:
inclusion criteria: * age 18 and above * diagnosed with axial low back pain (low back pain more severe than pain in other parts of the body, without radiation of pain into the lower extremities). * women of child bearing potential must have a negative serum pregnancy test at baseline. exclusion criteria: * diagnosed with rheumatoid arthritis, lupus, other autoimmune/systemic inflammatory arthropathies * progressive lower extremity weakness or numbness * recent oral steroid use (within last 3 months) * nsaid use * chronic kidney disease (egfr \<60) * diagnosis of diabetes mellitus * subjects must not be pregnant or breastfeeding, or planning to become pregnant or breastfeed during the course of the trial * unable to take an oral medication in a non crushable pill form * taking metformin presently or within the last 6 months * history of allergy to metformin * history of lactic acidosis * severe hepatic dysfunction * currently taking a diabetic medication such as sitagliptin, saxagliptin, linagliptin, alogliptin, sitagliptin with metformin * currently taking a carbonic anhydrase inhibitor such as topiramate, zonisamide, acetazolamide, dichlorphenamide, methazolamide * currently taking cimetidine

Keywords: low back pain metformin placebo
observational study to evaluate pad treatment clinical and economic outcomes

Conditions: Peripheral Arterial Occlusive Disease

Summary: the purpose of this study is to evaluate acute and long term clinical and economic outcomes of endovascular procedures to treat peripheral arterial disease (pad).

this is a prospective, observational, multi-center, clinical study examining predictors of clinical outcomes for patients undergoing endovascular treatment of lesions within or extending into the target area (10 cm above the medial epicondyle to the digital arteries). this includes disease in a vessel located within or extending into the distal superficial femoral artery (sfa), popliteal (pop), tibial peroneal trunk (tpt), anterior tibial (at), posterior tibial (pt), and peroneal tibial (pr) arteries.

Eligibility criteria:
inclusion criteria: 1. subject's age ≥ 18 years. 2. subject presents with a rutherford classification of 2 to 6. 3. subject presents with clinical evidence of pad requiring endovascular intervention on one or both limbs that includes a target lesion in a native vessel located within or extending into 10 cm above the medial epicondyle to the digital arteries. * if subject presents with bilateral disease, the first limb treated with a lesion in the target area will be considered the target limb. * for subjects with one or more wounds on the target limb, the target lesion(s) should be considered the lesion(s) in the vessel(s) that provide(s) blood flow to the wound(s). 4. subject has at least one lesion in a native vessel located within or extending into the target area that is crossed and treated with an endovascular device. exclusion criteria: 1. subject is unwilling or unable to sign the irb-approved informed consent form (icf). 2. subject is unable to understand or comply with the study protocol requirements. 3. subject is currently participating in an investigational drug or other device study that can clinically interfere with the endpoints of this study. 4. subject requires a conversion from endovascular intervention to a surgical bypass graft for any lesion(s) in the target area, as determined by the investigator. 5. subject has an in-stent restenosis in the target area, and this lesion is the only one requiring treatment. 6. subject is pregnant or planning to become pregnant within the study period. 7. subject has an anticipated life span of less than one (1) year.

Keywords: pad liberty observational
differential diagnosis of pulmonary hypertension with automated image analysis

Conditions: Pulmonary Hypertension

Summary: the aim of the study is to determine relevant morphologic parameters of the lung vasculature for the differentiation between different groups of patients with pulmonary hypertension (ph) by thoracic computer tomography (ct). in this pilot study patients undergoing right heart catheterization will be investigated by thoracic ct and special software to determine morphologic readouts. the investigators expect that using this non-invasive method, parameters relevant for the differentiation of the patients with ph can be determined.

pulmonary hypertension (ph) is defined as an elevated mean pressure in the pulmonary artery above 20mmhg determined at right-heart catheterization. depending on the presentation and pathogenesis, patients are classified according to five main groups. a correct classification is crucial, since it is essential for the available therapy options. a promising non-invasive method to provide important hemodynamic and clinical information is the fully-automatic analysis of thoracic computed tomography images. this method can yield a number of quantitative morphologic readouts of the lung vasculature and the parenchyma. this study aims to identify quantitative markers from the fully-automatic image analysis, which allow a discrimination between the various ph patient groups.

Eligibility criteria:
inclusion criteria: * patients with right-heart catheterization * clinical indication for thoracic ct exclusion criteria: * pregnancy * decreased kidney function * intolerance to contrast material * other standard ct contraindications
a study of nido-361 in patients with sbma

Conditions: Spinal and Bulbar Muscular Atrophy; Kennedy's Disease

Summary: the purpose of this study is to evaluate the safety, tolerability, and efficacy of nido-361 in adult patients with spinal and bulbar muscular atrophy (sbma).


Eligibility criteria:
inclusion criteria: * ambulatory male * documented sbma diagnosis confirmed by dna genetic testing * able to complete six-minute walk test (6mwt) exclusion criteria: * clinically significant cardiovascular, endocrine, hepatic, renal, pulmonary, gastrointestinal, neurologic, immunologic, malignant, metabolic, psychiatric, or other condition that, in the opinion of the investigator, precludes the participant's safe participation in the study or would interfere with the study assessments * inability to undergo mri (mild sedation may be allowed)
frailty prevention in elders from reunion island

Conditions: Frail Elderly Syndrome; Physical Activity

Summary: in reunion island, people encounter environmental and social conditions leading to premature ageing and subsequent frailty. social welfare has developped exercise programs to promote physical activity especially for elderly with higher risk factors of frailty, including low incomes. the study evaluates the potent benefit effect of such exercise program on physical performance and frailty improvement in seniors from reunion island. all seniors participate to a 12-weeks exercise program especially dedicated to this targeted population needs and ability.

regular physical activity has been shown to slow down sarcopenia, and increase strengh in elders. nevertheless, senior with low incomes do not usually have access to physical activity areas. social partners are in close relationship with these elders and could promote free exercise programs dedicated to elders classified as "gir5-6" according to the french scale "agirr". the agirr scale takes into account several criteria allowing the evaluation of the level of autonomy. the level of autonomy is closely related to frailty and could be reversed since elders have not reach a dependant-state. the "gir5-6" level means that elderly people are still not dependant but exhibit several frailty risk factors. the level of frailty and the physical performance of the participants is assessed by standard geriatric evaluation before the 12-wks exercice program. the improvement of the physical performance is assessed after he 12-wks exercice program.

Eligibility criteria:
inclusion criteria: * retired * with an autonomy level corresponding to the "gir 5-6" level of the french "agirr scale" * informed consent exclusion criteria: * physical activity prohibited * under guardianship
an adjunctive neurofeedback training program to enhance wellness among trauma-exposed postpartum mothers

Conditions: Well-Being, Psychological; Dissociation; Maternal Care Patterns; Maternal Behavior; Maternal Distress; Mood Disturbance; Emotional Regulation; Post Traumatic Stress Disorder

Summary: the proposed study will collect novel data evaluating the feasibility of the nfb training program delivered in an outpatient mental health setting and its influence on mothers' overall sense of well-being, and further investigate whether enhanced well-being is associated with positive changes in emotion regulation capacities, trauma-related mental health symptoms, parenting behaviors and attitudes, and infant behavioral outcomes (i.e., crying, fussing) among postpartum mothers with a history of childhood trauma and clinically concerning trauma-related mental health symptoms.


Eligibility criteria:
inclusion criteria: * must have clinically concerning symptoms of post-traumatic stress disorder and/or it's dissociative sub-type, as indicated by either a score of 3+ on the primary care ptsd screen for dsm-5 (pc-ptsd-5) screening measure for ptsd symptoms or endorsement of 2 or more past-month symptoms of moderate or greater severity on the depersonalization/derealization subscale of the dissociative subtype of ptsd scale (dsps). * must be between 3-24 months postpartum * must be receiving regular, primarily in-person psychotherapy from a therapist at a clinic in the greater detroit area. exclusion criteria: * are currently pregnant * have a lifetime history of significant untreated mental illness (not currently treated schizophrenia, schizoaffective disorder, bipolar disorder, or substance use disorder) or neurological or pervasive developmental disorder * have a documented history of epilepsy * have ever experienced previous head injury with loss of consciousness * are currently experiencing domestic or intimate partner violence or otherwise state that their current living conditions are unsafe * are currently experiencing psychosis or have been suicidal within the last six months * are currently taking, or in the past month has taken benzodiazepines, narcotic drugs, or cannabis * have engaged in self-harming behaviors in the last 3 months requiring medical attention * do not have competence to understand or consent to the study procedures * do not have fluency in written and spoken english