Kornimate/medical-research-clean huggingface dataset:
effects on patient satisfaction and gait after loss of peroneus longus function

Conditions: Patient Satisfaction; Gait, Rigid

Summary: at the foot and ankle group at the department of orthopaedics, uppsala university hospital, the routine is to perform a tendon transfer of peroneus longus to brevis in case of a ruptured peroneus brevis tendon in the ankle. the reports of patient outcome from this surgery varies in different studies. the aim of the current study is to analyse how well the patients think their general health has improved after the surgery, and how they perceive that the foot function has changed after the surgery. in an objective way the changes in gait after surgery will be measured with gait analysis.

the patients are asked to fill in short form 36 (sf 36) and foot and ankle outcome score (faos) before surgery, six months and one year after surgery. at each visit a clinical examination is done by a foot and ankle surgeon, according to a protocol. at the same visit a gait analysis is performed with force plates, registration of speed and gait length and 3d recording. the surgery itself is performed according to the clinic's usual protocol and standardised, so all patients are treated in the same way. the physiotherapy is also done according to a protocol. the surgeon is not involved in the follow- up, this is done by another surgeon, and the gait analysis is done by a physiotherapist. the patients are chosen from two groups: primary tear of the peroneus brevis tendon, requiring a longus to brevis transfer, and primary tear of the peroneus longus tendon, requiring removal of the tendon. the first group has a sub-group: patients who are in need of a calcaneal osteotomy because of a severe varus hindfoot. the reason the study group is so heterogenous is that peroneus longus and brevis tears are very rare, and 10 patients are referred to the orthoaedic deparment each year, that need this type of surgery. the sample size has been calculated to 30 patients (based on changes in force measurements during gate), but more patients need to be involved in the study in order to have 30 patients at one year follow up.

Eligibility criteria:
inclusion criteria: 1. tears of the peroneus longus and/or peroneus brevis tendon, verified on mri. 2. eligible for surgery of peroneal tendon tears exclusion criteria: 1. other injuries in the affected foot that might affect the gait. 2. previous surgery in the affected foot that might affect the gait. 3. neurological conditions in the lower extremities that might affect the gait. 4. patient can not understand the questionnaires or can not understand swedish

Keywords: cavovarus foot gait analysis tendon transfer
physical/self-perceived performance and 3d shoulder kinematics of volleyball attackers with/without shoulder complaints and scapular dyskinesis

Conditions: Shoulder Pain

Summary: the study aims to compare the performance and the 3d shoulder kinematics of volleyball attackers with and without scapular dyskinesis and shoulder symptoms in two physical performance measures of the upper extremity, and correlate their outcomes with a self-reported measure of function of the upper extremity.

volleyball attackers with clinically identified scapular dyskinesis and with/without shoulder symptoms will be compared with respect to performance outcomes and scapular kinematics. performance will be assessed by means of the unilateral seated shot put test (usspt), the upper quarter y balance test (uqybt), and disabilities of the arm, shoulder and hand, sports module (dash). pain measurements after completing physical performance measures will be assessed and rated. relationships between physical (usspt, uqybt) and self-perceived (dash) measures of performance, and with impairment-based measures (clinical measures and 3d shoulder kinematics) will be assessed.

Eligibility criteria:
inclusion criteria: * subjects who can perform at least 150 degrees of arm elevation exclusion criteria: * subjects rating pain ≥8/10 * score 5 on any of the items of the dash * pain elicited by provocation maneuvers of the neighboring regions (e.g., cervical spine).
application of an electronic nose in the early detection of aspergillosis

Conditions: Pulmonary Invasive Aspergillosis

Summary: the purpose of this study is to establish the accuracy with which the enose can discriminate patients with invasive pulmonary aspergillosis from controls.


Eligibility criteria:
inclusion criteria: patients that 1. are 18 years of age or older 2. will undergo treatment for a hematological malignancy expected to result in grade 4 neutropenia (according to ctcae 3.0, i.e. \<0.5 x 109 neutrophils/l) of prolonged duration (i.e., more than 7 days), e.g. hematopoietic stem cell transplantation or induction/consolidation treatment for acute myeloid leukaemia 3. have given written informed consent exclusion criteria: 1. a previously diagnosed invasive mycosis 2. the inability to perform the breathing manoeuvre needed for enose-analysis of exhaled air
pilot trial of peer support for bipolar disorder

Conditions: Bipolar Disorder

Summary: this pilot effectiveness trial will evaluate the feasibility, acceptability, and effectiveness of a structured peer support program based on the certified peer specialist program of the depression and bipolar support alliance (dbsa).

bipolar disorder is a chronic and often disabling illness affecting 1-2% of us adults. peer support programs are an innovative and promising model to reverse demoralization, activate consumers to seek more effective care, develop consumers' self-management skills, and restore participation in work and other social roles. peer-led programs can address key barriers to dissemination of effective psychosocial treatment. this pilot effectiveness trial will evaluate the feasibility, acceptability, and effectiveness of a structured peer support program based on the certified peer specialist program of the depression and bipolar support alliance (dbsa). following the philosophy of recovery, the intervention focuses on: * motivating consumers to develop an expectation of recovery * encouraging regular self-monitoring of mood symptoms * training consumers to develop self-management skills for symptom control and problem solving * activating consumers to be more informed partners in care and more effective self-advocates * motivating and assisting consumers to reclaim work and other rewarding social roles the investigators will use a rigorous research design to evaluate how structured peer support promotes core values of mental health recovery. impact of the intervention will be judged across a range of outcomes: * long-term control of mood disorder symptoms * optimal participation in work and other rewarding social roles * consumers' perceptions of autonomy and full participation in the treatment process findings from this pilot study will inform the development of a full-scale effectiveness trial to include a broader range of participants and health care settings.

Eligibility criteria:
inclusion criteria: * ghc members aged 18 and over with bipolar disorder type 1 or type 2 and at least 6 weeks during the past 3 months with a depression or mania/hypomania psychiatric status rating of 3 or greater (indicating significant symptoms at least half of the time). potential participants will not be excluded because of medical, psychiatric, or substance use comorbidity. exclusion criteria: * children under age 18.

Keywords: bipolar peers dbsa
development and validation of new "snu illustrated pain rating scale" as a tool for postoperative pain assessment

Conditions: Pain Measurement; Acute Pain; Postoperative Pain; Anesthesia; Surgery

Summary: the numeric rating scale (nrs), one of the most widely used pain scales in clinical practice, although convenient, is often subject to bias because it requires abstract thinking from both the patient and the evaluator. compared to numbers, traumatic pain, when visualized appropriately, has potential advantage as a means to indicate and communicate the severity of pain. given that they are standardized in terms of body parts, wound size, and bleeding volume, illustrations of traumatic pain along with external somatic stimuli that caused it can be used to serve as effective visual anchors to supplement a pain scale by giving more concrete information to the patient. the purpose of this study is to develop seoul national university illustrated pain scale(snuips) using pictures of traumatic pain, and verify the validity and effectiveness of this scale in comparison with those of nrs.


Eligibility criteria:
inclusion criteria: * adult patients undergoing a gynecological or orthopedic surgery under general anesthesia * administered with intravenous patient-controlled analgesia for postoperative pain control * american society of anesthesiologists physical status class i-iii patients exclusion criteria: * contraindicated against fentanyl * unable to communicate * aged less than 18, or more than 79 * weighs less than 40kg or more than 89kg * has severe heart disease(s) * pregnant

Keywords: pain measurement acute postoperative pain
coca-cola vs. oxygen for fatigue management in tibet surgeons

Conditions: Fatigue

Summary: the study will be conducted among surgeons in tibet, comparing the effects of coca-cola and supplemental oxygen on fatigue alleviation. additionally, pre-planned subgroup analyses will examine the potential differences in effectiveness between tibetan surgeons who have long lived in high-altitude areas and han surgeons who work in these areas for shorter periods. the investigators hypothesize that for tibetan surgeons, coca-cola will be more effective in alleviating fatigue, while for han chinese surgeons, supplemental oxygen will be more effective.

fatigue in surgeons can result in reduced concentration and muscle strength, compromising the safety of surgical procedures, particularly in high-altitude areas. in tibet, surgeons often drink cola or inhale oxygen during operations, as these are believed to help alleviate fatigue. this study aims to evaluate the effects of coca-cola and supplemental oxygen in relieving fatigue among surgeons in tibet and to investigate whether these effects vary based on the ethnicity of the doctors. this study employs a stepped-wedge cluster randomized controlled trial design, recruiting 22 surgeons (k=22). each doctor is scheduled to perform 24 surgeries and evaluated. at the beginning of the trial, all surgeons will drink cola. the supplemental oxygen will be administered in a random sequence to all participants until each has received the intervention. the primary outcome measure is the change in concentration performance scores before and after surgery (δcp). the secondary outcome measure is the change in maximum voluntary hand grip strength before and after surgery (δmvc). the study follows the intention-to-treat principle, including all subjects who have entered the randomization sequence in the analysis of the primary outcomes.

Eligibility criteria:
inclusion criteria: * surgeons employed at the people's hospital of the tibet autonomous region, including both tibetan doctors with long-term experience in high-altitude areas and han doctors working in high-altitude areas temporarily; * capable of serving as the lead surgeon in operations lasting at least 2 hours; * having lived and worked continuously in lhasa for a minimum of 3 months, without traveling to low-altitude areas during this period; * fully understanding of this research and willing to sign a written informed consent form. exclusion criteria: -

Keywords: surgeon fatigue supplemental oxygen coca-cola
investigation the effects of stabilization exercises on pain, disability and activity of pelvic floor muscles in patients with postpartum lumbopelvic pain

Conditions: Postpartum Lumbopelvic Pain

Summary: the purpose of this study was to evaluate the effects of stabilization exercises on pain, disability and pelvic floor muscles function in patients with lumbopelvic pain.

pregnancy is a specific experience that leads to several physical changes in women's body and influence most aspects of their lives. pregnancy and delivery can cause serious complications such as urinary incontinence, pelvic organ prolapse, fecal incontinence, and low back pain (lbp) that have negative effects on women's sexual, physical, social and psychological health. based on wu et al. systematic review, prevalence of pregnancy related low back pain (plbp) during pregnancy and postpartum is 45% and 25% respectively. lbp is one of the most current causes of disability and sick leave after delivery.abnormal load transfer in the lumbopelvic region has been considered as one possible explanation to lumbopelvic pain.the local stabilizing muscles, i.e. the transversely oriented abdominal, diaphragm, the lumbar mf and the pfm play an important role in load transfer in the lumbopelvic region.so, we considered that an exercise program that addresses muscular dysfunction, such as lumbar stabilization exercise can improve motor pattern of local stabilizing muscles and can use in management of postpartum lumbopelvic pain.

Eligibility criteria:
inclusion criteria: * age more than 18 years old * pain located between costal margin to gluteal fold with or without radiation to lower limbs * onset of pain during pregnancy or after delivery * history of delivery at least 3 months ago. exclusion criteria: * known chronic rheumatologic or orthopedic disorders * systemic locomotor disease * history of fracture, neoplasm,intervertebral disk pathology or radiculopathy, spondylolysis or spondylolysthesis * contraindication of exercises, heart disease, diabetes, thrombophlebitis, uncontrolled epilepsy * ongoing pregnancy * treatment with specific stabilisation exercise during previous 3 months.

Keywords: pregnancy pelvic floor muscles lumbo-pelvic pain stabilization exercises abdominal muscles thickness multifidus muscles thickness multifidus muscles cross section area
open-label extension study in patients 65 years or older with chronic lymphocytic leukemia or small lymphocytic lymphoma

Conditions: Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma

Summary: an open-label extension study in patients 65 years or older with chronic lymphocytic leukemia (cll) or small lymphocytic lymphoma (sll) who participated in study pcyc-1115-ca (ibrutinib versus chlorambucil)


Eligibility criteria:
inclusion criteria: 1. randomized in the parent study, pcyc-1115-ca 2. informed consent for study pcyc-1116-ca 3. independent review committee (irc)-confirmed disease progression (pd) in the parent study pcyc-1115-ca or closure of the parent study exclusion criteria: 1. disease progression involving the central nervous system (cns) or transformation to another histology 2. intervening chemotherapy, immunotherapy, or investigational agent specifically to treat cll if administered before date of irc confirmed progressive disease 3. in the 4 weeks before dosing: radiation therapy, major surgery, or receipt of an investigational drug 4. requirement for treatment with a strong cyp3a inhibitor 5. uncontrolled systemic infection or requirement for iv antibiotics 6. noncompliance on the parent study(pcyc-1115-ca)

Keywords: cll sll
the effect of laryngeal manual therapy as a management of globus

Conditions: Globus

Summary: the purpose of this study is to assess the effect of laryngeal manual therapies in the treatment of globus (sensation of a lump in the throat).

this is a prospective study that include patients who met the inclusion criteria. data collection includes patients age,gender,clinical manifistations,laboratory parameters and treatment. an endoscopic examination will be done by an expert otolaryngologist. for each patients we will perform one session of laryngeal manual massage therapy by an expert in the field .

Eligibility criteria:
inclusion criteria: * patients more than 18 years old * male and females * patients complaning from globus without an organic cause * patients who underwent throat endoscopy and was normal. * patients who received conventional drug therapy without benefit. * globus complaints more than two months . exclusion criteria: * below 18 * patients diagnosed with reflux(as a cause to globus) * patients who considered at high risk of reflux according to reflux symptom index (rsi) more than 13 * patients who diagnosed with reflux and improved after anti-reflux manegment . * patients with laryngeal disease/finding that can explain the globus. * patients with organic cause that can explain the globus .
endoscopy screening for esophageal cancer

Conditions: Head and Neck Cancer

Summary: patients with head and neck cancer frequently develop synchronous or metachronous esophageal malignancies. previous studies have demonstrated the efficacy of endoscopic screening for esophageal cancer in head and neck cancer patients. the narrow band imaging (nbi) system, an optical technology that enhances the visualization of superficial vascular network, may be superior to the conventional white light endoscopy for the detection of neoplastic lesions. however, whether the application of nbi improves the detection results have not been critically evaluated. this study aims to investigate the diagnostic value of the nbi system in the endoscopic screening for esophageal neoplastic lesions in patients with head and neck cancer.

this is a prospective blinded controlled tandem endoscopy trial conducted in a regional medical center (lotung poh-ai hospital, taiwan). patients with tissue diagnosis of head and neck cancer are enrolled. endoscopy screening for esophageal lesions is first performed by using the conventional white light system. suspicious lesions are recorded. then the entire esophagus is examined under the nbi system by another endoscopist, who is blinded to the result of the conventional endoscopy. after the endoscopic inspection completed, all suspicious lesions are biopsied. before each procedure, which one of the two participating endoscopists applies the conventional or nbi system is randomized. the diagnostic rate of esophageal neoplasm by the conventional white light system and that of the nbi system are compared. the endpoint is the neoplastic lesion detected on endoscopic biopsy. we considered invasive cancer, carcinoma in-situ, and high-grade dysplasia (which usually cannot be distinguished from carcinoma in situ) as the primary points. any dysplastic lesions were considered as secondary points.

Eligibility criteria:
inclusion criteria: * patients with tissue diagnosis of head and neck cancer * histopathology of head and neck cancer is carcinoma (including squamous cell carcinoma, adenocarcinoma or undifferentiated) * aged more than 18 years old * agree to under go upper gastrointestinal endoscopy exclusion criteria: * lack of written informed consent * the origin of head and neck cancer is metastatic * histopathology of head and neck cancer is not carcinoma (e.g., sarcoma, lymphoma, etc) * incomplete upper gastrointestinal endoscopy

Keywords: esophageal cancer head and neck cancer narrow band imaging endoscopy screening
evaluation of clinical characteristics and pathological findings in patients with suspected appendicitis

Conditions: Appendicitis

Summary: as we know, one of the most common reasons for people to visit health centers and hospitals (15%) is abdominal pain, and appendicitis is at the top of their diagnosis in the 2-4th decade of age, which in most cases for treatment, considering the patient's condition and the need for surgery, appendectomy is the first method. one of the things that helps us a lot in this area is the epidemiology and incidence of this disease in the target society, which sometimes varies in different regions. one of the things that can be checked in this disease is the age and gender of the person and its incidence in different age ranges.

appendicitis is one of the most important reasons for people to go to the hospital, and 15% of the visits to the hospital are for this reason, and sometimes patients end up undergoing appendectomy. the mortality rate of this disease is 0.2-1% among young people and 8% among people over 65 years old in some people, depending on the sex, age, pregnancy and related diseases and even the weight of the people, the location of the appendix is different and this issue is very important during surgery. different positions of the appendix, such as retro-scapular, subhepatic, pelvic, etc., create different challenges during surgery, so investigating the possibilities of the location of the appendix is an important issue in the decision-making and preparation of the patient and the surgical team. also, laboratory criteria such as wbc, diff, plt, crp can also help in diagnosing this disease. in this project, in addition to the above, the chief complaints and accompanying symptoms of people have also been examined

Eligibility criteria:
inclusion criteria: * diagnosis of appendicitis * appendectomy exclusion criteria: * lack of required information in medical documents

Keywords: appendicitis appendectomy appendicitis diagnosis
transcranial magnetic stimulation for post-traumatic stress disorder

Conditions: Post-Traumatic Stress Disorders

Summary: the purpose of this study is to determine if transcranial magnetic stimulation at 1 hz to the right frontal cortex will decrease the symptoms of post-traumatic stress disorder (ptsd).

post-traumatic stress disorder (ptsd) is a psychiatric disorder that is common in the general population. ptsd symptoms include re-experiencing the traumatic event, avoidance of reminders of the trauma, and increased arousal. the primary treatments of ptsd are psychotherapy and antidepressant medications. while both are effective, many patients continue to have significant symptoms. repetitive transcranial magnetic stimulation (rtms) is a new research and treatment modality that uses a small powerful electromagnet to directly stimulate the brain. this stimulation may increase or decrease brain activity. the treatments have been shown to be effective in other disorders such as depression. initial treatment of patients with ptsd using rtms has been hopeful. this study is the first randomized controlled trial to examine the efficacy of rtms for ptsd. this study would be the first randomized placebo controlled trial to examine the efficacy of transcranial magnetic stimulation (rtms) for ptsd. the primary hypothesis is that there will be significant improvement in the patients' ptsd symptoms from pre-treatment to post-treatment with rtms. a secondary hypothesis is that the patients' co-morbid depressive symptoms will improve from pre-treatment to post-treatment. forty subjects with ptsd will be recruited from the white river junction vamc. patients will be randomly assigned to receive either active rtms or sham rtms. patients, staff performing the treatments, and staff completing the assessments will all be blinded to active or sham treatment.

Eligibility criteria:
inclusion criteria: * ptsd diagnosis on standardized assessment * medically stable * eligible veteran of united states (us) military exclusion criteria: * active substance abuse * history of seizures * metal in head or neck

Keywords: post traumatic stress disorder ptsd trauma transcranial magnetic stimulation randomized clinical trial