Kornimate/medical-research-clean huggingface dataset:
effects of repetitive transcranial magnetic stimulation on fear of cancer recurrence: mpfc-amygdala-hippocampus

Conditions: Psychology

Summary: introduction: previous studies have shown that many breast cancer patients are suffering from fear of cancer recurrence (fcr). however, effective physical intervention for fcr has been scarce. in this study, low-frequency repetitive transcranial magnetic stimulation (rtms) targeting the right dorsolateral prefrontal cortex (dlpfc) will be applied on patients with high fcr. we aim to assess the efficacy of low-frequency rtms in the treatment of fcr in breast cancer patients. methods and analysis: this will be a two-arm, randomised controlled trial comparing rtms, sham stimulation in breast cancer patients with high fcr. a total of 50 breast cancer patients with a high fcr score (\>27) will be recruited. patients will be randomly assigned to receive 4-week rtms, sham stimulation. assessments will be conducted at week 0 (baseline), week 4 (the end of intervention), week 5 (1 week post-treatment), week 8 (1 month post-treatment), and week 16 (3 months post-treatment). the primary outcome of the study will be to ascertain, whether the rtms program is sufficient in relieving fcr in breast cancer patients (measured by the 7-item fcr scale). additionally, gad7, phq9, nrs, and isi7 will be used to measure individual's anxiety, depression, pain, and insomnia symptoms.

this study will be a parallel assignment randomised controlled trial (rct). patients will be randomly assigned to rtms intervention group (rtms+ tau), sham stimulation group (sham+ tau). treatment will be performed 5 times a week for 4 weeks. assessments will be conducted at week 0 (baseline), week 4 (the end of intervention), week 5 (1 week post-treatment), week 8 (1 month post-treatment), and week 16 (3 months post-treatment). the screening, assessments, allocation and intervention will all be carried out via a wechat mini program (a widely used social communication application, with more than 1.2 billion users in china) specially tailored for the trial. an information sheet will be provided online, and informed consent will be completed online before participation in the study.

Eligibility criteria:
inclusion criteria: 1. adult; 2. breast cancer patients undergoing treatment for the first time; 3. able to understand and sign informed consent; 4. being able to comply with the intervention. exclusion criteria: 1. minors; 2. having a diagnosis for a significant untreated mental or medical illness (e.g., consciousness disturbances, mania, acute phase of schizophrenia, major depressive disorder, etc.); 3. patients with recurrent cancer; 4. hospice patients.
indiana university gastric electrical stimulation registry

Conditions: Gastroparesis

Summary: the purpose of this study is to develop a clinical registry in patients with gastric electrical stimulation (ges) therapy for gastroparesis to support future gastrointestinal therapies, medical procedures and diagnostics.

this study will evaluate male and female patients at least 18 years of age, with gastroparesis, who will or have already undergone the implantation of a ges device the study will be conducted at one center and approximately 1,000 subjects will be enrolled. subjects undergoing the ges implantation will be enrolled before the implantation and may have a baseline visit. the visit procedures will be conducted at the discretion of the investigator dependent on the clinical condition of the patient at that time.

Eligibility criteria:
inclusion criteria: * patients undergo implantation of a new ges device for medical refractory gastroparesis exclusion criteria: * non-ambulatory patients: bed-ridden, nursing home resident, etc. * pregnancy * unable to give own informed consent. * prisoners

Keywords: gastroparesis gastric electrical stimulator ges vomiting nausea bloating post prandial fullness epigastric pain
to assess adherence to the treatment and quality of life in patients with hypertension

Conditions: Hypertension

Summary: the main goal of this study is to achieve a deeper knowledge of the adherence to antihypertensive drug treatment and to evaluate the quality of life in this population. this work has the following goals: primary objective is to assess the antihypertensive treatment adherence in patients with essential hypertension on treatment for more than 6 months. the secondary objectives include the assessment of quality of life, identification of associated factors that affect adherence, knowledge of drugs used and comparison of levels of adherence according to the different drug regimes two questionnaires shall be prepared the first questionnaire shall be anonymously completed by the patient willing to participate. it is divided into two parts: 1. treatment adherence scale (mmas): this survey is made up of 4 questions having yes/no answers and it grants 1 point per every "no" answer, and zero points to every "yes" answer. 2. the second part is the health-related quality of life questionnaire (minichal). the questions refer to the "last 7 days" with 4 possible answer options: 0 (no, absolutely not), 1 (yes, sometimes), 2 (yes, frequently) and 3 (yes, a lot). it is made up of 16 items, 10 correspond to the "state of mind" dimension and 6 to the "body-related symptoms," also described as "physical symptoms". the second questionnaire shall be completed by the intervening physician as regards patients that attend medical visits, and who have answered the anonymous questionnaire.


Eligibility criteria:
inclusion criteria: * patients with diagnosis of essential hypertension under the criteria established by the joint national committee vii (9) and those patients under pharmacological treatment with the same therapeutic regime during at le exclusion criteria: * patients with secondary hbp * pregnant women or nursing mothers * patients with acute illnesses or having a definite psychiatric diagnosis, as well as those patients who are unable to completed

Keywords: hypertension health-related quality of life adherence to the antihypertension treatment ambulatory patients minichal score treatment adherence scale (mmas) quality of life adherence to treatment
validation of a new sexuality questionnaire for patients with urinary incontinence or pelvic organ prolapse

Conditions: Pelvic Organ Prolapse; Urinary Incontinence; Fecal Incontinence

Summary: the main objective of this study is to perform the linguistic validation of a new french questionnaire in a population of sexually active (or not) patients who have undergone surgery (or not) for stress urinary incontinence or genital prolapse.


Eligibility criteria:
inclusion criteria: * the patient is able to read and understand french * the patient must be insured or beneficiary of a health insurance plan * patients suffering from pelvic organ prolapse and/or urinary incontinence and/or fecal incontinence. exclusion criteria: * patient is pregnant * the patient is under judicial protection, under tutorship or curatorship * the patient does not understand french

Keywords: linguistic validation of a new questionnaire
anesthesia related neurocognitive deficits in children

Conditions: Anesthesia

Summary: the infantile brain has to pass essential, mayor steps in the first 36 months of life. during that period of development it is particularly vulnerable to toxic, exogenic influences. this study wants to review the long-term effects of children who were exposed to anesthesia in the first three years of their life. therefore the investigators will examine children at age of 4-10 that were exposed to anesthesia and compare their neurocognitive capacity to children who did not have any exposure to anesthesia. the investigators plan on measuring the intelligence quotient using standardized tests which will be performed by a trained psychologist. in addition there will be a questionnaire concerning behavioral characteristics and educational development which is filled by the parents. the exposed children will be recruited from our preexisting database, the control group will be recruited from practitioners and the pediatric walk-in-clinic.


Eligibility criteria:
inclusion criteria: * general anesthesia before the age of 36 months exclusion criteria: * neurosurgical interventions * cardiac surgery * preexisting hereditary or acquired cognitive deficits * no informed consent

Keywords: anesthesia children general anesthesia neurocognitive outcome
characterization of sitting postures in healthy subjects

Conditions: Pressure Ulcer

Summary: the aim of this study is to assess the intra and inter-subjects variability of the pressure measurement cartography in healthy and well and able volunteers, sitting on a rigid base during two hours.

* the purpose of this study is to understand the formation of pressure sore, to improve the care of paraplegic patients. * this pilot study is going to help to establish a model in healthy volunteers in the prevention of pressure sores.

Eligibility criteria:
inclusion criteria: * more or equal than 18 years old * age between 20 and 30 years old * affiliation to social security or similarly regime exclusion criteria: * person with pacemaker * person with a history of lumbar pain, chest or/and cervical pain. * person with an history of lumbar, chest or/and cervical muscular disorders, * person with history of circulatory problems, * person with history of skin pathologies at the seat area, * protected person referred to in articles l1121-5 to l1121-8 of the code of public health * person having a total annual compensation for the participation in biomedical research higher than €4460.

Keywords: pressure ulcer prevention
evaluation direct and indirect composite restoration in hypomineralization molars.

Conditions: Dental Enamel Hypoplasia; Dental Caries

Summary: the aim of this study is to evaluate the effectiveness of direct and indirect composite restoration in children with molar incisor hypomineralization patients (mih) and following up after 3 , 6 , 12 months (clinically): group a ( control group ): hypomineralization molars were restored by direct composite. group b ( experimental group ): hypomineralization molars were restored by indirect composite.

pediatric dentists face a high prevalence of mih ranging from 3 to 40%, so it is relatively common condition that would cause treatment challenges due to severe sensitivity, breakdown of the occlusal surface, difficulty anesthesia and relatively high failure of restorations as a result of marginal breakdown of restorations. there are many treatment options available to restore these teeth. in mild and moderate cases, they are restored using direct composite resin. in cases where teeth are severely affected, the treatment is more complicated, including stainless steel crowns and different types of full or partial indirect crowns. direct composite resin restorations are the treatment option in the majority of clinical cases, but in severe cases, the results of treatment are often unsatisfactory. indirect composite restorations are an aesthetic alternative to cast metal inlays and stainless steel crowns with minimal microleakage.

Eligibility criteria:
inclusion criteria: 1. age between 8 and 12 years. 2. definitely positive or positive ratings of frank scale. 3. the first permanent molars must achieve the following criteria: the molar must be suffering from severe demineralization and it must be restorable with composite. 4. caries lesions include the occlusal surface and should not extend more than thirds of the thickness of dentin 5. absence clinical and radiographic signs which indicate pulp necrosis exclusion criteria: 1. systematic or mental disorders. 2. definitely negative or negative ratings of frankel scale 3. existence periapical translucence 4. existence external or internal abnormal absorption 5. existence swelling or fistula 6. sensitivity to percussion 7. existence of spontaneous or stimulant pain

Keywords: mih direct composite indirect composite permanent molars
the role of mid-life adiposity in functional brain connectivity

Conditions: Alzheimer's Disease

Summary: the purpose of the study is to use functional mri (fmri) to measure brain connectivity in middle-aged individuals with different levels of body fat. the ultimate goal of this research is to develop an early diagnostic tool for alzheimer's disease.

participants will have one visit for: * blood draw * body composition scan * cognitive screen * neurological exam * mri scan the visit will take approximately 3 hours.

Eligibility criteria:
inclusion criteria: * 45-65 years of age * normal memory * right-handed * general good physical health exclusion criteria: * history of stroke or neurological disease * seizures or head injury with loss of consciousness within the last five years * ferrous (magnetic) or electronic implants (due to the magnet in the mri scanner) * claustrophobia more detailed inclusion/exclusion criteria must be met in order to qualify for the study. the study coordinator will determine eligibility.

Keywords: fmri dementia alzheimer's disease functional neuroimaging memory
moving on study - pilot test

Conditions: Breast Cancer Female

Summary: the purpose of this study is to conduct a pilot test of "moving on after breast cancer (move-abc)" - a physical therapy based educational intervention designed to reduce and manage breast cancer-related physical and functional impairments. this pilot test will allow the investigator to determine whether move-abc is feasible and holds promise for efficacy for delivery after breast cancer treatment has ended just as the breast cancer survivor enters the surveillance for recurrence phase of cancer survivorship. the study team will be recruiting breast cancer survivors who have just finished intent-to-cure treatment and are just about to execute their cancer survivorship plans.

the investigators hypothesize that move-abc is a critical missing link in the standard of care to reduce impairments and improve confidence to manage impairments. the research team is positioned to pilot test move-abc to address (a) self- management of breast cancer-related impairments via patient-centered booklet and video each impairment identified by our breast cancer survivors; (b) instruction on self-management of impairments with the "moving on" booklet and video (attachment 4.1); and (c) weekly follow-up (up to 1 month after the end of breast cancer treatment) to answer questions, concerns and review "moving on". this research also supports a small but growing number of studies that point to self-management interventions informed by rehabilitation as a means to fill this gap in usual care. the investigator has already piloted the "moving on" intervention among surgical candidates for breast cancer surgery. the question remains whether "moving on" is acceptable and feasible for breast cancer survivors who have already completed their breast cancer treatment and are just beginning to execute their breast cancer survivorship plans.

Eligibility criteria:
inclusion criteria: * newly diagnosed and treated bc (stages 0-4) * female * english speaking * 21 years old or older exclusion criteria: * previous history of cancer (except non-melanoma skin) * history of shoulder impairment (e.g. shoulder osteoarthritis, rotator cuff tear, adhesive capsulitis) * pregnancy * central nervous system damage (e.g.: spinal cord injury, brain injury, multiple sclerosis, etc.) * dementia * systemic medical conditions and/or metal implants (e.g. fibromyalgia, rheumatoid arthritis, diabetes, joint replacement, cardiac pacemaker, port-a-cath etc.) * upper extremity(ies) amputation * actively receiving physical therapy for any reason prior to enrollment
mobile health technology to promote physical activity in persons with parkinson disease

Conditions: Parkinson Disease

Summary: persons with parkinson disease (pd) face significant declines in function resulting in greater disability. function can improve through participation in exercise, yet many people with pd are physically inactive. given that people with pd live long lifespans following diagnosis; it is essential to include routine exercise into their lives over the long-term. physical therapy is effective in improving function in persons with pd. however, participation in on-going physical therapy indefinitely is not a realistic option due to limited healthcare resources. interventions using mobile health technologies allow physical therapists to stay connected to patients over time potentially improving their ability to meet the changing needs of patients with pd. innovative approaches using mobile health technology may improve outcome; however, the effectiveness of different approaches to improve function and reduce disability in pd is unknown. the purpose of this study is to compare the effectiveness of two interventions to improve function and health-related quality of life in 65 people with pd. in one study group, participants receive a home exercise program, in written format, to continue on an independent basis. in the other study group, participants are instructed to continue with an exercise program, in their home, delivered using videos of the exercises on a computer tablet device. this use of mobile-health technology allows the physical therapist to remotely monitor participants' progress and modify the exercise program to meet the changing needs of each patient. the long-term objective of this research is to determine the most efficient and effective way to improve function that can be widely disseminated to persons with pd.


Eligibility criteria:
inclusion criteria: * inactive over the last 3 months * clinical diagnosis of idiopathic parkinson's disease * mild to moderate disease severity * sufficient cognitive ability to follow study instructions * stable dose of parkinson's medications for at least 2 weeks prior to study onset and during the 12 month study period unless medically necessary * able to walk without physical assistance or an assistive device for at least 6 continuous minutes * be interested in participating and provide informed consent exclusion criteria: * a diagnosis of atypical parkinsonism * balance impairment (more than 2 falls in the previous month) * significant freezing * serious co-morbidities or medical conditions that may interfere with ability to participate in an exercise program (i.e., musculoskeletal, cardiovascular, and neurological (other than parkinson's))

Keywords: exercise rehabilitation telemedicine
managing our relationship with food and eating

Conditions: Mental Health Wellness 1; Eating Behavior; Stress, Psychological; Eating Habit

Summary: there is a need for population-level intervention research to address the impacts of the covid-19 pandemic on disordered eating and unhealthy eating behaviours. systematic reviews have demonstrated that psychotherapy and yoga can help to reduce binge eating and disordered eating habits, however, these interventions were tested in person. studies examining the effectiveness of these interventions in an online, group-based format are warranted. in 2019, the investigators launched a rct to test gender-stratified group interventions to address mental health and addictive behaviours among community-based adults in southern alberta. the investigators implemented this intervention with more than 200 adults in person before this study was paused due to covid-19; in 2020, the investigators adapted this intervention for online delivery to 200 community-dwelling women across alberta. the most recent iteration of this study indicated the participants were particularly concerned about their relationship with food and how they were engaging in different eating behaviours to cope with the stress of covid-19.

the primary objective of this project is to adapt two existing mental health and substance use interventions and rct for online delivery to address unhealthy eating behaviours and a negative relationship with food for women within the context of covid-19. the second objective is to test if an online group body-oriented intervention (trauma-sensitive yoga) that has been designed to increase awareness of physical sensations, is superior to an online group verbal narrative intervention (mental wellness talking circle), and to control group. the investigators theorize that the body-oriented intervention may offer the opportunity to reprogram automatic physiologic hyperarousal in response to covid-19 triggers and increase positive body awareness, and mindful attention to the ways in which habitual self-protective behaviours, like unhealthy eating behaviours, may be impacting health. the third objective is to examine the impacts of the interventions on adults with pre-existing mental health and disordered eating issues, and those with previous experiences that may make them more susceptible to these problems during covid-19. the investigators will track other supports they engage in during the study and the perceived impacts of these supports on their outcomes with the goal of shedding light on how to best match covid-19 related services to adults who need them the most.

Eligibility criteria:
inclusion criteria: * women between 18-75 years living in alberta, canada * need to have reliable access to the internet, a device with a webcam for the next 2 months * need to self-identify that they are currently struggling with at least one of: stress eating, alcohol use, drug use, tobacco use, or gambling during the pandemic exclusion criteria: * non-community dwelling * not currently residing in alberta, canada
chemotherapy w/wo weileshu in metastatic colorectal cancer

Conditions: Microbial Colonization; Colorectal Cancer

Summary: a total of 50 patients with metastatic colorectal cancer will be enrolled in the study. the patients were randomly divided into the wls-intervention group and the control group. the two groups of patients were given the most appropriate medication according to the specific conditions of the disease. patients in the intervention group received additional oral administration of weileshu, a probiotics product (tongchuang biotechnology).


Eligibility criteria:
inclusion criteria: * at least 18 years of age, of any race or sex who are eligible to sign written consent and have undergone prior resection of histological evidence of colorectal cancer * hematologic function: anc ≥ 1.5 x 10 /l, platelets ≥ 75 x 10 /l, and hemoglobin \> 9 g/dl adequate liver function as measured by: total bilirubin ≤ 2.0 mg/dl, ast and alt ≤ 5 uln, albumin ≥ 2.5 g/dl adequate renal function as measured by: creatinine ≤ 2.9 mg/dl, \> 50 ml/min calculated by the c-g equation non-pregnant women of childbearing potential and fertile men are required to use effective contraception (negative pregnancy test for women of child-bearing age) ecog status ≤ 1 at screening exclusion criteria: -
a trial investigating nn1218 in subjects with type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial is conducted in europe. the aim of this trial is to investigate the absorption and effect in the body of nn1218 in subjects with type 1 diabetes.


Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus for more than 12 months * treated with multiple daily insulin injections or continuous subcutaneous insulin infusion (csii) for more than 12 months * body mass index (bmi) between 18.0-28.0 kg/m2 (both inclusive) exclusion criteria: * subject who has donated any blood or plasma in the past month or more than 500 ml within 3 months prior to trial start * smoker (defined as a subject who is smoking more than 5 cigarettes or the equivalent per day) * not able or willing to refrain from smoking and use of nicotine gum or transdermal nicotine patches during the inpatient period