Kornimate/medical-research-clean huggingface dataset:
hyaluronan in the treatment of painful achilles tendinopathy.

Conditions: Tendinopathy

Summary: the primary objective of this study is to compare ostenil® tendon (2% hyaluronan) and extracorporeal shock wave (eswt) therapy in the treatment of painful achilles tendinopathy.


Eligibility criteria:
inclusion criteria: * male and female patients between 18 and 75 years of age. * good general health condition. * signed written informed consent. * painful achilles midportion tendinopathy since more or equal than 6 weeks. * pain according to vas (huskisson, 100 mm) more or equal than 40 mm. * ensured compliance of subjects over the whole study period. exclusion criteria: * concomitant or previous participation in a clinical investigation within the last 3 months prior to study inclusion. * infection or relevant skin disease at study relevant site. * blood coagulation disorder or intake of blood thinner (e.g. marcumar). * known hypersensitivity to hyaluronic acid (ha) preparations or to the constituents mannitol, sodium chloride, disodium phosphate and sodium dihydrogenphosphate. * contra-indications for eswt application in study relevant area (e.g. recent surgery, malignant tumour, local osteomyelitis or open epiphysis). * severe intercurrent illness (e.g. uncontrolled diabetes mellitus, peripheral neuropathy), which in the opinion of the investigator, may put the patient at risk when participating in the study, or affect the patient's ability to take part in the study. * concomitant disease at study relevant site (e.g. insertion tendinopathy at achilles tendon) influencing study evaluation. * diseases or characteristics judged by the investigator to be incompatible with the assessments and/or procedures for the study evaluation. * intake of concomitant medications not allowed which might interfere with the functional assessment of the study (e.g. immunosuppressive drugs within the last 3 months). * previous therapies (except non-steroidal anti-inflammatory drugs (nsaid)) at study relevant site within the last 4 weeks prior to study inclusion. * use of nsaids within the last week prior to study treatment. * recent history of drug and/or alcohol abuse (within the last 6 months). * pregnant or lactating females. * participants of childbearing age (pre-menopausal) who do not accept the use of methods of birth control with pearl index of at least 1 (i.e. oral contraceptives, vaginal ring, hormone-releasing intrauterine device (iud), implants, depot syringes, hormone patch, double barrier method, tubal ligation, vasectomised partner,...) during the treatment period and the first 4 weeks of follow-up period. * subjects not capable of contracting and of understanding the nature, risks, significance and implications of the clinical investigation and unable to form a rational intention in the light of these facts. * subjects unable to understand informed consent or having a high probability of non compliance to the study procedures and / or non completion of the study according to investigator's judgement (e.g. illiteracy, insufficient knowledge of local language).

Keywords: tendinopathy hyaluronan tendon hyaluronic acid extracorporeal shock wave
reducing attention deficit hyperactivity disorder in kindergarten and pre-kindergarten children

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: this study will determine the effectiveness of an intervention for preventing at-risk kindergarten and pre-kindergarten children from developing attention deficit hyperactivity disorder.

attention deficit hyperactivity disorder (adhd) is characterized by inattention, impulsiveness, and hyperactivity. adhd is not commonly diagnosed until a child has entered formal schooling and shown academic and behavioral adjustment difficulties, but developmental research suggests that risk factors for developing adhd are evident earlier. a significant number of children start school with high levels of disorganized and inattentive behaviors, which are symptoms of emerging adhd. this study will test an intervention aimed at preventing the development of adhd by identifying those at risk for developing adhd in kindergarten and pre-kindergarten and teaching them self-regulation skills through socialization. these skills have been associated with school success, and they may reduce the likelihood of children developing adhd. participation in this study will last for 4 months, with a follow-up assessment after 1 year. to enroll, child participants will undergo a screening process that will include assessments by their teachers and parents. eligible child participants will also be assessed by researchers in a classroom setting. they will then be randomly assigned to receive either a play-based intervention, called the friendship group, or an individual pre-academic tutoring intervention. both groups will meet at school. the friendship group, which will focus on strengthening attention and self-regulation through social skills, will involve 30 sessions twice a week for 15 weeks. the tutoring intervention, which will focus on strengthening academic skills, will involve one or two sessions a week for 4 months. participants will be assessed at three time points: pre-intervention, post-intervention, and after 1 year. assessments will include teacher ratings and direct testing of child attention, language, and pre-academic skills.

Eligibility criteria:
inclusion criteria: * clinical or subclinical levels of adhd symptomatology, based upon teacher and parent report exclusion criteria: * presence of sensorimotor disability, frank neurological disorder, or psychosis * estimated full scale intelligence quotient (fsiq) less than 70 * very low levels of english proficiency that preclude completion of the assessment battery * in a temporary custody situation with uncertain outcome

Keywords: adhd psychosocial intervention social skills training
highly sensitive serum cardiac troponin t and cardiovascular events in patients with systemic lupus erythematosus

Conditions: Systemic Lupus Erythematosus

Summary: identification of biological markers able to better stratify cardiovascular risks in systemic lupus erythematosus patients is needed. we aimed to determine whether serum cardiac troponin t levels measured with a highly sensitive assay (hs-ctnt) may predict cardiovascular events in systemic lupus erythematosus.

cardiac troponin (ctnt) is a marker of myocyte necrosis and injury in the early phase of acute myocardial infarction. measured with high-sensitivity (hs) assays, hs-ctnt has proven predictive value for coronary heart disease, heart failure, and mortality in the general population at apparent low-risk for cardiovascular events. in a previous study, our group showed that hs-ctnt concentration was associated with subclinical atherosclerosis in systemic lupus erythematosus patients. the aim of this study was to determine whether hs-ctnt was associated with incident cardiovascular events in systemic lupus erythematosus

Eligibility criteria:
inclusion criteria: * patient with a systemic lupus erythematosus exclusion criteria: * inadequate follow-up period (\< 20 months) -past history of cve at baseline for inclusion in the tropoplus study

Keywords: systemic lupus erythematosus cardiovascular risk biomarkers troponin t
osteopathic manual treatment for hemiplegic shoulder pain and upper extremity function in stroke patients

Conditions: Hemiplegic Shoulder Pain; Osteopathic Manipulative Treatment

Summary: this study assesses the feasibility and safety of performing osteopathic manual treatment (omt) for hemiplegic shoulder pain in stroke patients. this study's participants will be adults with a first-time stroke diagnosis in the past 5 years and shoulder pain on the same side affected by stroke. eligible participants will be placed on study for approximately 6 weeks and given either omt or a sham treatment each week.


Eligibility criteria:
inclusion criteria: * patients must be at least 18 years or older to participate in the study * presence of shoulder pain on the side of the body affected by stroke * patients must have a diagnosis of a first-time stroke within the past 5 years * stroke type must be subcortical, brainstem, and/or right-mca stroke. participants with multiple stroke types within the first-time diagnosis may be included exclusion criteria: * presence of an active systemic or localized infection requiring antibiotic therapy * presence of fracture in the area being treated * presence of open wound in the area being treated * presence of rheumatoid arthritis * presence of known active malignancy * presence of shoulder pain on the affected side within 3 months prior to stroke * patients with left-mca stroke diagnosis who demonstrate the presence of aphasia based on the mississippi aphasia screening test (mast) * patients who demonstrate hemispatial visual neglect based on screening motor-free visual perception test (mfvpt) * patients already receiving any type of manual therapy by a certified therapist through their standard-of-care treatment * patients who do not wish to participate * patients who are not fit as judged by the study team * patients who lack the capacity to consent for enrollment in the study based on the university of california san diego brief assessment of capacity to consent

Keywords: stroke hemiplegic shoulder pain osteopathic manual treatment omt
a study of orforglipron (ly3502970) compared with dapagliflozin in adult participants with type 2 diabetes and inadequate glycemic control with metformin

Conditions: Type 2 Diabetes

Summary: the main purpose of this study is to assess the safety and efficacy of orforglipron compared with dapagliflozin in improving blood sugar control in participants with type 2 diabetes (t2d) with inadequate glycemic control using metformin. the study will last approximately 46 weeks.


Eligibility criteria:
inclusion criteria: * have a clinical diagnosis of t2d based on the world health organization classification or other locally applicable diagnostic standards. * have hba1c ≥7.0% (53 mmol/mol) to ≤10.5% (91 mmol/mol) at screening. * have been on stable diabetes treatment with metformin ≥1500 milligram per day (mg/day) during the 90 days prior to screening and maintained through randomization. * are of stable body weight (±5%) for at least 90 days prior to screening and agree to not initiate an intensive diet or exercise program during the study with the intent of reducing body weight, other than the lifestyle and/or dietary measures for diabetes treatment. * have a body mass index (bmi) ≥23.0 kilogram/square meter (kg/m²) at screening. exclusion criteria: * have type 1 diabetes (t1d) * are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * have an estimated glomerular filtration rate (egfr) \<45 milliliter per minute (ml/min)/1.73 square meter (m2) * have acute or chronic hepatitis * have had chronic or acute pancreatitis any time. * have been treated with any antihyperglycemic medication (other than metformin) within the 90 days prior to screening.
neurophysiological correlates of dissociation induced by virtual reality hypnosis (vrh) in a clinical population

Conditions: Cancer

Summary: hypnosis and virtual reality are potential tools for treating acute. nevertheless, the neurophysiological correlates of such tools used together, i.e. 'virtual reality hypnosis' (vrh) (patterson et al., 2004) remain mostly understudied. this study aims to improve our knowledge and understanding of the dissociation (i.e., a mental separation of components of behaviours that normally would be processed together) occurring during vrh. this is a clinical trial aiming at understanding if the vrh reduces pain during a port-a-cath intervention in oncological patients and if dissociation may explain the pain alteration.

the study will be focused on oncological patients undergoing a port-a-cath placement procedure. day-1 and day-2 with a one-day follow-up day-3: i. day-1: oncological population (feasibility) 1. recruitment and questionnaires on the day of the port-a-cath preparation consultation (day-1): i. a medical screening will be performed to assess eligibility, ii. elkins hypnotizability scale. iii. state trait anxiety inventory-trait (anxiety trait) iv. dissociative experience scale. v. tellegen absorption scale. vi. questionnaire of immersion propensity. ii. day-2: 1. intervention day: i. visual analogy scale: * anxiety. * pain. ii. 4-electrodes eeg device from oncomfort during port-a-cath (port) placement procedure under virtual reality hypnosis (vrh), combined standard monitoring (spo2, heart rate, etc.) iii. adverse events will be recorded throughout the experiment iv. visual analogy scale: * dissociation. * pain. * anxiety * absorption. * arousal/wakefulness. * automaticity v. time perception (open-ended question) vi. presence questionnaire. vii. satisfaction questionnaire. 2. follow-up (day-3): i. a follow-up questionnaire using the brief pain inventory (bpi) french version will be sent to the patient one week after the intervention to measure outcomes.

Eligibility criteria:
inclusion criteria: subject more than 18 years old exclusion criteria: 1. low auditory and/or visual acuity precludes the use of the device. 2. head or face wounds precluding the use of the device. 3. schizophrenia, dissociative disorder or any other psychiatric disorder. 4. non-proficiency in french (research language). 5. patient under 18 years old. 6. phobia of deep water. 7. allergy to cutaneous electrodes. 8. chronic pain and/or chronic analgesics consumption. 9. medication affecting the autonomic nervous system. 10. dizziness.

Keywords: virtual reality hypnosis dissociation
ipsihand system for rehabilitation of the arm and hand after stroke

Conditions: Stroke; Hemiparesis

Summary: this study aims to assess whether the neurolutions upper extremity rehabilitation system (known as ipsihand) will help stroke patients regain strength and functional movements in their arm. the ipsihand system involves using a hand robotic device that is controlled by brain waves, known as a brain-computer interface (bci). by using the device, participants will be harnessing brainwaves from the side of their brain not affected by stroke to control the robotic device on the hand that is weaker from the stroke.

this trial aims to assess the effectiveness of the neurolutions upper extremity rehabilitation system, known as ipsihand, on functional motor recovery and neuroplasticity for chronic stroke survivors with hemiparesis (n=27). the ipsihand system involves a brain-computer interface (bci) as a control for a robotic hand orthosis. participants will complete 16-32 weeks of home therapy with the ipsihand system.

Eligibility criteria:
inclusion criteria: * diagnosis of stroke(s), with most recent stroke at least 6 months prior to study start (can be ischemic or hemorrhagic) * prom: full extension of digits 2 and 3 at mps, pips, and dips * english speaking * intact cognition to provide informed consent * intact language skills to comprehend and follow directions * experiencing difficulty performing adls with affected upper limb * upper extremity botox allowable, but not required * botox users must continue regimen at regular intervals for duration of study * botox users will provide clinic note for each injection (date, dose, and muscle location) * botox + study schedule * at study initiation, botox injection will occur between 3-7 days prior to baseline measurement and initiation of device use * repeat botox injections must be completed at least 3 days prior to any administration of the outcome measures exclusion criteria: * concurrent participation in another study * co-morbid orthopedic condition/pain limiting functional use of the impaired upper limb * history of neurological disorder other than stroke * botox user unable to comply with above noted requirements * ongoing physical or occupational therapy addressing the upper limb * ongoing electric stimulation or other rehabilitative devices (e.g. robotics, virtual reality) to upper limb * cognitive impairment: short blessed test score 9 * significant spasticity: modified ashworth scale score 3 at the elbow * significant hemispatial neglect: mesulam cancellation test 3 unilaterally * insufficient strength: motricity index score for shoulder abduction 18 * significantly impaired sensation of impaired upper limb: national institutes of health stroke scale - item 8 (sensory) score of 2 * history of cranioplasty * history of seizure disorder * no changes to usual exercises, splint use, or oral baclofen/anti-spasticity medication use during trial

Keywords: stroke hemiparesis rehabilitation upper extremity neurological rehabilitation neuronal plasticity brain-computer interfaces robotics
the effect of yoga training on menopausal symptoms on menopausal women

Conditions: Menopause

Summary: parallel to the increase in life expectancy by years, the population of women living in the post-menopausal period is also increasing. in order to have a healthy menopause, which is an important part of women's life, it is thought that the adoption of yoga practice without health risks by women and its implementation as a lifestyle may be effective in reducing the symptoms of menopause experienced by women. in line with this information, it is aimed to determine the effect of yoga training on menopausal symptoms. the research will be carried out with menopausal women between the ages of 40-60 in famagusta region. women will be divided into two groups as intervention and control. personal information form and menopause rating scale will be used in the research. the intervention group will be given yoga practice two days a week for 10 weeks. menopause rating scale will be applied to the intervention and control group before and after the research.

parallel to the increase in life expectancy by years, the population of women living in the post-menopausal period is also increasing. in order to have a healthy menopause, which is an important part of women's life, it is thought that the adoption of yoga practice without health risks by women and its implementation as a lifestyle may be effective in reducing the symptoms of menopause experienced by women. in line with this information, it is aimed to determine the effect of yoga training on menopausal symptoms. the research will be carried out with menopausal women between the ages of 40-60 in famagusta region. women will be divided into two groups as intervention and control. personal information form and menopause rating scale will be used in the research. the intervention group will be given yoga practice two days a week for 10 weeks. menopause rating scale will be applied to the intervention and control group before and after the research.

Eligibility criteria:
inclusion criteria: * willing to participate in research, * can read and write in turkish, * open to communication, * those who are between the ages of 40-60 and do not experience menstruation for at least one year, do not use medication to treat menopausal symptoms, * no diagnosed musculoskeletal disease, no severe heart disease, * not doing regular exercise and yoga, * not surgically menopausal, * women without psychiatric problems exclusion criteria: * refusing to participate in research, * can't read and write turkish, * communication is not possible, * those who are younger than 40 or older than 60 have experienced menstruation for at least one year * using medication for the treatment of menopausal symptoms, * those with a diagnosed musculoskeletal disease, severe heart disease, * doing regular exercise and yoga, * surgically menopausal, women with psychiatric problems

Keywords: menopause yoga symptoms
quality of life following radical prostatectomy

Conditions: Prostatic Neoplasms; Prostate Cancer

Summary: this study will utilize the expanded prostate cancer index composite questionnaire to learn what impact the surgery has upon the participant's sense of health, sexual and urinary quality of life.

to define impact on quality of life issues for patients undergoing radical prostatectomy. this study will distribute a questionnaire to patients who are being scheduled for radical prostatectomy, both before and after surgery, to assess the impact on quality of life issues. this will provide important information regarding the temporal return of issues pertaining to quality of life.

Eligibility criteria:
inclusion criteria: - patients scheduled to undergo radical prostatectomy at stanford exclusion criteria: - patients treated with neoadjuvant or adjuvant hormonal therapy or radiation therapy

Keywords: quality of life
dasatinib combined with chemotherapy in relapsed t(8;21) acute myeloid leukemia with kit d816 mutation

Conditions: Relapsed AML; T(8;21); C-KIT Mutation

Summary: in this multi-center, open-label, no control,prospective clinical trial, a total of 30 relapsed acute myeloid leukemia with t(8;21) translocation and kit d816 mutation patients will be enrolled. dasatinib 70 mg twice a day will be administrated for two weeks from day 1 of re-induction chemotherapy. the purpose of current study is to determine the clinical efficacy and tolerability of combination therapy of dasatinib with multi-agent chemotherapy in relapsed acute myeloid leukemia with t(8;21) translocation and kit d816 mutation.


Eligibility criteria:
inclusion criteria: 1. t(8;21)acute myeloid leukemia patients with kit d816 mutation diagnosed by bone marrow morphology, immunology, molecular genetics. the diagnosis and classification are according to who 2016 criteria. 2. conform to relapsed diagnosis.only morphological relapsed cases will be enrolled.molecular relapsed and isolated extramedullary relapsed cases are not eligible. 3. age is not limited. both male and female are eligible. 4. eastern cooperative oncology group performance status (ecog-ps):0-2 point. 5. informed consent form must be signed by patients themselves before enrolled for patients aged 18 years or older. informed consent form must be signed by the legal guardian for patients younger than 18 years. exclusion criteria: 1. patients with other blood diseases at the same time (such as haemophilia, primary myelofibrosis and so on) are not considered suitable. 2. isolated extramedullary relapsed leukemia. 3. with other malignant tumors accompanied with aml and needed treatment. 4 .patients who are unsuitable for the trial considered by investigators.

Keywords: leukemia,myeloid, acute relapse mutation kit dasatinib
a survey of psychological status of medical workers and residents in the context of 2019 novel coronavirus pneumonia

Conditions: Virus; Pneumonia

Summary: due to the outbreak of 2019 novel coronavirus pneumonia in wuhan, hubei province, medical staff and residents are facing great psychological pressure, the investigator plan to use electronic questionnaire to carry out investigation research.

from december 2019, 12 cases of new coronavirus pneumonia broke out in wuhan, and then the epidemic spread rapidly. till february 1, 2020, there were 14446 confirmed cases in china, 19544 suspected cases, and 304 deaths. there were confirmed cases reported in 34 provincial administrative regions in china; 23 foreign countries reported new coronavirus pneumonia cases, 147 confirmed cases. in the face of the rapid spread of the epidemic, people's panic and anxiety have seriously affected the prevention and control of the epidemic. in the face of the occupational exposure risk and treatment brought by the sudden outbreak of the epidemic, the change of mental state of medical staff may affect the prevention and control of the epidemic. in order to help the epidemic prevention and control, the investigator plan to carry out investigation research.

Eligibility criteria:
inclusion criteria: * can use mobil phone or computer * volunteer to take part in the investigation exclusion criteria: * can not use phone or computer * unwilling to take part in the investigation