Kornimate/medical-research-clean huggingface dataset:
capillary blood volume and pain perception obtained in a process of puncturing with different safety lancets

Conditions: Healthy

Summary: the study was a randomized, single blind, uni-center pivotal study in male and female healthy volunteers, to determine capillary blood volume and pain perception obtained in a process of puncturing with different safety lancets. a group of three hundred (300) caucasian male and female subjects was randomized (aged \> 18 to \< 65 years old) who were in good physical and mental condition. the subjects had 4 (four) fingers (two fingers from each hand) lanced each with a different type of safety lancet. overall, 4 (four) different safety lancets were investigated per each subject. overall, 48 (forty eight) different safety lancets (4 different safety lancets per one subject) were investigated, the capillary blood volume and pain were measured.


Eligibility criteria:
inclusion criteria: * willing to sign the informed consent. * male and female volunteers * age between 18 and 65 inclusive * able to communicate well with the investigator and comply with the requirements of the study * volunteers who are in good physical and mental health exclusion criteria: * confirmed or suspected malignant cancer * pregnancy or breastfeeding (only for women with childbearing potential based on pregnancy test conducted at site) * history of poor blood circulation. * any skin condition on his or her fingers that prevents blood sampling * anxiety with needles or finger pricks * clotting disorders (including bleeding) in medical history * neuropathy or other condition affecting sensation in the hands. * history of blood borne infection (e.g., hiv, hepatitis b or c, syphilis, malaria, babesiosis, brucellosis, leptospirosis, arboviral infections, relapsing fever, t lymphotropic virus type 1, creutzfeldt-jakob disease) * currently participating in another study * history of drug or alcohol abuse within the 12 months prior to screening or evidence of such abuse * intake of alcohol within 48 hours prior to the start of the study (self-reporting) * donation or loss of 400 ml or more of blood within 4 weeks prior to the start of the study * any other condition that in the investigator opinion may negatively influence subject's participation in the study * intake of medicines that affect blood coagulability (including anticoagulants such as vitamin k, antivirals and anticoagulants such as heparin, aspirin, thrombin inhibitors, vitamin k antagonists).

Keywords: safety lancets lancet capillary blood capillary blood sampling blood volume pain
symptoms and quality of life (qol) after palliative pelvic radiation of prostate and rectal cancers

Conditions: Prostatic Neoplasms; Rectal Neoplasms

Summary: the purpose of this study is to assess the effect of palliative pelvic radiation on symptoms and quality of life among patients with incurable prostate and rectal cancer.

with the aging population, the prevalence of cancer is on the rise, leading to an increased demand for effective palliative treatment. there is little scientific information describing the effects of palliative radiotherapy among patients treated for soft-tissue tumors of the pelvis. this is a treatment that is used relatively frequently, but delivered heterogeneously since the optimum fractionation schedule has yet to be established. this study aims to define the effects of one such fractionation schedule (3gy x 10-13) and thus, establish a foundation for future fractionation studies.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * histologically or cytologically proven adenocarcinoma of the prostate or rectosigmoid colon. * incurable disease (hormone-resistant in cases of prostate cancer) * life expectancy \> 3 months * symptomatic soft-tissue pelvic tumor mass (primary, recurrence or metastases) * planned fractionated radiotherapy (3gy x 10-13) * written informed consent exclusion criteria: * unable to fill out questionnaires (due to language or cognitive barriers) * new systemic tumor-targeted treatment (hormone manipulation, chemotherapy, monoclonal antibodies, etc.) started within four weeks of baseline or during the 6 weeks immediately following pelvic radiotherapy. * previous pelvic radiotherapy * the presence of a second primary pelvic cancer or other cancer requiring treatment * currently receiving treatment with an investigational drug

Keywords: prostatic neoplasms rectal neoplasms palliative treatment radiotherapy quality of life
platelet reactivity in patients with nuisance bleeding on a thienopyridine

Conditions: Platelet Aggregation; Bleeding

Summary: the objective is to describe and quantify levels of platelet reactivity in three different cohorts of patients taking thienopyridine: patients who report nuisance bleeding, patients who report alarming bleeding, and patients who report no nuisance or alarming bleeding. the investigators hypothesize that patients with nuisance or alarming bleeding events on maintenance thienopyridine therapy will have lower levels of platelet reactivity than patients without nuisance or alarming bleeding on thienopyridine therapy.


Eligibility criteria:
inclusion criteria: * patients 18 years or older from both genders * underwent pci within the last year * taking maintenance dose of clopidogrel 75 mg once a day or prasugrel 10 mg once a day for at least five days exclusion criteria: * known allergies to aspirin, clopidogrel, or prasugrel. * use of a glycoprotein (gp)iib/iiia inhibitor within 8 hours of the blood draw. * patient known to be pregnant or lactating * patient with known history of anemia, thrombocytopenia, bleeding disorder, or currently active bleeding * on warfarin therapy at the time of blood draw * known blood transfusion within the preceding 10 days of the blood draw * patients treated with non-steroidal anti-inflammatory drugs (nsaids, not to include aspirin) within the previous 5 days * any significant medical condition that, in the investigator's opinion, may interfere with the patient's optimal participation in the study.
endometriosis and migraine

Conditions: Migraine; Endometriosis

Summary: this study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. participants will complete surveys, experimental pain paradigms and collection of samples for hormone analyses.

participants will be recruited via the pain, headache and ob/gyn clinics, via volunteers for health, via other studies in the lab, study staff, and via epic. when potential participants are inquiring about studies with the pain the lifespan lab, the study team will describe this study among the options. potential participants might be identified via epic records using age, sex, diagnoses, notes, problem list, medications, and phone number. a research staff member will contact a potential participant and provide a description of the project. potentially eligible participants will be invited to participate in the study, which will be conducted at washington university school of medicine. participants will also be provided with a written summary of or the consent form for the study. the consent will be signed electronically using docusign e-consent process either remotely during a phone call or a video call (wustl zoom) with a study staff or in person. after confirming the inclusion criteria and signing the consent form, participants will complete a 2.5-3 hour study visit of psychophysical assessments of thermal and pressure stimuli. participants will also complete various questionnaires including demographic, social, health, behavioral, and psychological questionnaires. for adolescents, a parent/legal guardian will be asked to assist in completing some of the health-related surveys (i.e., physical developmental survey, health survey, migraine history survey). obstetric, gynecologic, fertility, surgical history, medications, and pain will be abstracted from the medical record and/or via health history interview. blood, urine, and/or saliva samples will be collected for hormonal, immune, and/or genetic testing. additional samples will be stored in a biobank for future hormonal, immune and/or genetic analyses. participants will then complete follow-up surveys once monthly for up to 1 year after the study visit which will assess changes to their pain symptoms and treatments. all study procedures are optional, and participants can stop or not complete tests if they want.

Eligibility criteria:
inclusion criteria: 1. patients with diagnosed endometriosis, migraine, or both endometriosis and migraine 2. healthy control subjects with no history of chronic pain 3. age 12-45 4. assigned female sex at birth exclusion criteria: 1. pregnancy or breastfeeding 2. presence of prolactinoma 3. presence of psychiatric, neurological, endocrinological and/or developmental conditions and taking medications for these conditions 4. current use of dopamine agonist or ssri medications 5. for patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health

Keywords: migraine endometriosis hormones pain
predictive value for stroke

Conditions: Carotid Artery Stenosis

Summary: patients with a moderate to severe carotid atherosclerotic plaque are at risk for stroke and this risk increases with increasing degree of stenosis. it has been shown that carotid endarterectomy in symptomatic patients with a carotid artery stenosis of 70-99% is highly beneficial. however, the beneficial effect of surgery in patients with symptomatic 30-69% stenosis is not clear yet.a clear beneficial effect of surgery in the 30-69% stenosis group might be found in a sub-group of patients whom are at greater risk for stroke. definition of this sub-group might be achieved by plaque characterization, since rupture of a vulnerable plaque is the main cause of stroke due to carotid artery stenosis.this study will include patients with a 30-69% carotid artery stenosis, and assess plaque composition by mri, the degree of plaque inflammation by fdg-pet, and the amount of microembolization by transcranial doppler ultrasound. the main purpose of this study is to assess whether one or a combination of each of these imaging methods can predict the occurrence of a (recurrent) ischemic stroke.


Eligibility criteria:
inclusion criteria: * patients with neurological symptoms due to ischemia in the carotid artery territory and with a carotid stenosis between 30% and 69% as detected by ultrasound examination exclusion criteria: * patients with a probable cardiac source of embolism (rhythm disorders, mitral valve stenosis, prolapse or calcification, mechanical cardiac valves, recent myocardial infarction, left ventricular thrombus, atrial myxoma, endocarditis, dilated cardiomyopathy, patent foramen ovale) or a clotting disorder. * patients with evident other cause of neurological symptoms than carotid stenosis due to atherosclerotic disease (like demyelinating diseases, epilepsy, congenital brain disorders, aneurysms, fibromuscular dysplasia, etc.). * patients already scheduled for carotid endarterectomy or stenting * severe co-morbidity, dementia, or pregnancy. * standard contra-indications for mri (ferromagnetic implants like pacemakers or other electronic implants, metallic eye fragments, vascular clips, claustrophobia, documented allergy to contrast media, renal insufficiency, etc). * patients who were referred from another hospital to one of the three participating hospitals (to avoid referral bias). * patients who had a tia or minor stroke more than 3 weeks before inclusion * patients who had a prior tia or stroke
screening contrast-enhanced mammography

Conditions: Breast Cancer

Summary: the main objective of this study is to compare the diagnostic performance of two diagnostic methods, namely cesm and mri, in the evaluation of a lesion suspicious of breast cancer in 300 quebec women referred for the investigation of breast cancer. breast lesion suspected of cancer. all suspicious lesions will be evaluated by these two diagnostic imaging and by tnm. then, radiologists will respectively interpret diagnostic imaging, without knowing the result of the other imaging in parallel with the study. the sensitivity, specificity, positive predictive value and negative predictive value for his diagnostic imaging will then be determined. histopathological confirmation by biopsy or surgery will be used as a standard value.


Eligibility criteria:
inclusion criteria: * female aged 18 and over * at least one breast lesion with birads classification 5 exclusion criteria: * refusal to perform the biopsy or surgery * pregnant or possibly pregnant woman * usual contraindication to contrast product * significant kidney failure * allergy to contrast medium * hyperthyroidism * usual contraindications to mri
the checklist for early recognition and treatment of acute illness (certain)

Conditions: Critical Illness; Sepsis; Respiratory Failure; Shock; Coma; Bleeding; Trauma

Summary: the purpose of the study is to test whether the health care provider access and training in certain (checklist for early recognition and treatment of acute illness), would facilitate timely and error free best-practice delivery and minimize preventable death and costly complications in critically ill patients.


Eligibility criteria:
inclusion: all adult (≥ 18 years) patients admitted for the first time to the participating icus will be included. exclusion: not critically ill, admitted for low risk monitoring, planned icu admissions for routine postoperative surveillance for less than 24 hours after uncomplicated surgery, readmission and transferred from outside icu.

Keywords: certain, checklist, icu, outcome, adults
the association of genetic polymorphisms with statin-induced myopathy.

Conditions: Rhabdomyolysis; Myopathy

Summary: to observe not only the distribution of single nucleotide polymorphism in genes related with pharmacodynamic and pharmacokinetics alteration of statins but also to analyze the correlation between these snps and the incidence of statins-induced myopathy.

statins are widely prescribed for the patients with hypercholesterolemia. though their efficacy in preventing cardiovascular events has been shown by a large number of clinical trials, myotoxic side effects including myopathy or even more severe,rhabdomyolysis are associated with the use of statins. because the incidence of myopathy is various among individuals,polymorphism in genes is supposed to be the main factor. due to single nucleotide polymorphism in related genes,level of uptake, clearance and metabolism of statins can be seriously different among individuals resulting in various occurrence of myopathy. therefore, analytical study in association between snp of statins-related genes and the incidence of myopathy is such a critical research which can be applied into clinical fields.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of rhabdomyolysis because of prescription with statins exclusion criteria: * carnitine palmityl transferase ll deficiency * mcardle disease * myoadenylate deaminase deficiency

Keywords: muscle disorder statins creatine kinase
stromal vascular fraction and autologous activated platelet-rich plasma combination in treating treatment of type 2 diabetes

Conditions: Diabetes Mellitus, Type 2; Platelet-rich Plasma; Stromal Vascular Fraction

Summary: this study was a retrospective study on type 2 diabetes patients that were treated with autologous stromal vascular fraction (svf) and autologous activated platelet-rich plasma (aaprp) measuring hba1c level at baseline, 1-month, 3-month, 6-month, and 12-month post-treatment.

the preparation of svf used the h-remedy (jakarta, indonesia) method invented by hayandralab. manual liposuction was performed to collect the lipoaspirate. the aaprp was prepared using an in-house method of hayandralab. the svf pellet was resuspended in 0.9% normal saline, resulting in a total of 22 ml svf suspension. 7 ml of cell suspension was used for quality control. a total of 15 ml svf suspension was mixed with 3 ml aaprp. a total of 20 ml of svf and aaprp suspension was injected into an infusion bag which contained 250 ml of 0.9% normal saline. the mixture of svf and aaprp was then infused intravenously to each patient for a duration of around 30 minutes. the infusion was given on the day of the patient's lipoaspiration procedure. the patients underwent three subsequent infusions of svf and aaprp combination, followed by four aaprp infusions. these therapy sessions were scheduled with a 2-weeks interval. inclusion criteria: 1. patients who were diagnosed with type 2 diabetes (t2d) for at least 2 years with the diagnosis of t2d and treatment with oral anti-hyperglycemic therapy with metformin were in accordance with the guideline for management and prevention of t2d by the indonesian society of endocrinology. 2. patients who have undergone standard oral anti-hyperglycemic therapy with metformin and had not been able to reach normal hba1c level with the medication 3. patients who underwent autologous svf-aaprp therapy between january until december 2017 exclusion criteria 1. patients who were pregnant 2. patients who were below 18 years of age 3. patients who were on insulin therapy

Eligibility criteria:
inclusion criteria: * patients who were diagnosed with t2d for at least 2 years * patients who have undergone standard oral anti-hyperglycemic therapy with metformin and had not been able to reach normal hba1c level with the medication * patients who underwent autologous svf-aaprp therapy between january until december 2017 exclusion criteria: * patients who were pregnant * patients who were below 18 years of age * patients who were on insulin therapy.

Keywords: glycosylated hemoglobin a1c platelet-rich plasma stromal vascular fraction type 2 diabetes mellitus
effect of the pelvic floor training in postmenopausal women with or without hormonal therapy

Conditions: Weak; Pelvic Floor; Weak; Muscle; Urinary Incontinence

Summary: the purpose of this study is to evaluate the effect of pelvic floor muscle training (pfmt) on muscle function of postmenopausal women using or not using hormonal therapy replacement (htr). the study will evaluate also the prevalence of urinary incontinence reports, its severity and impact on quality of life.

the climacteric period is marked by the decline of estrogens and androgens which represents negative effect on the urogenital system and may present, as a consequence, pelvic floor muscles (pfm) dysfunction and urinary incontinence (ui). the pelvic floor muscles training (pfmt) and hormone therapy (ht) could result in a significant increase in muscle mass with functional improvement and consequent decrease in complaints of urine loss. the aim of this study is to evaluate the effect of pfmt on muscle function, in the presence of ui, severity and impact on quality of life in postmenopausal women with or without ht. the variable sexual function was abandoned due to the fact that the majority of the women do not presented active sexual life, which is a criteria to answer the questionnaire index of female sexual function (ifsf), or did not agree to answer the questionnaire. the anxiety scale was also abandoned because it was a tool to assess sexual function in a broader way. this is a randomized controlled trial. postmenopausal women will be divided into 4 groups: * group 1- without exercise and without ht * group 2 - with exercise and without ht * group 3 - without exercise and with ht * group 4 - with exercise and ht women will be evaluated at baseline and up to 12 weeks. the evaluations of the pfm function will be accomplished through the use of vaginal palpation using the modified oxford scale (mos) and perineometry. the international consultation on incontinence questionnaire- short form (iciq - sf) will be used to assess reports of ui, quality of life will be evaluated by the sf36 (medical outcomes study 36 - item short - form health survey). the electromyography was not performed because during the collection of data from the pilot sample there was an excess of outcome measures which made the patients' adhesion unfeasible.

Eligibility criteria:
inclusion criteria: * postmenopausal women with a maximum of ten years of menopause. * it is considered menopausal cessation of menstrual cycles for more than twelve months (who). * to be included women must have the ability to contract the pelvic floor muscle (pfm) and have never done pfm training. exclusion criteria: * women with diabetes mellitus, thyroid disease, hyperprolactinemia, genital prolapse (above grade 1), neuropathy and vasculopathy. * those who are intolerant (pain, allergy gel or latex condom or other discomfort) to pfm function evaluation and those that deny answer the questionnaires during the protocol.
kegel exercise-focused interventions in elderly women

Conditions: Urinary Incontinence; Kegel Exercises; Nursing

Summary: purpose: this study was conducted to investigate the effects of kegel exercises-focused intervention undergone by elderly women diagnosed with urinary incontinence on their incontinence, quality of life and perceived impact level. design: the study has a single-blind randomized controlled experimental research design. methods: the study was carried out between december 2017 and march 2019 with 60 elderly women registered at the home health unit of a metropolitan municipality in turkey. the women were assigned to the intervention (n=30) and control (n=30) groups. the participants in the intervention group were paid home visits to provide them with individual training and counseling on kegel exercises. whether the participants did the exercises was followed up by weekly phone calls. the frequency of urinary incontinence, the amount of urine leaking and the quality of life of the participants and their complaints about incontinence were assessed with the international consultation on incontinence questionnaire short form and questions on the assessment of the perceived impact at the onset of the study (0th week), and at home visits paid at the 6th and 12th weeks after the intervention.


Eligibility criteria:
inclusion criteria: * over the age of 65, * being women, * diagnosed with ui, * being literate, * being able to communicate in turkish, * standardized mini mental test result was \> 24, * agree to participate in research. exclusion criteria: * who had received training on incontinence and kegel exercises in the last 1 year, * had symptoms of urinary tract infection were identified, * being treated for ui, * having health problems affecting the muscle and nervous system, * being not able to perform daily life activities, * having pelvic organ prolapse,
intravitreal bevasizumab versus intravitreal triamcinolone in branch retinal vein occlusion

Conditions: Branch Retinal Vein Occlusion

Summary: this randomized clinical trial is conducted to evaluate the effect of three intravitreal injections of bevasizumab versus two intravitreal injections of triamcinolone in acute retinal vein occlusion. the outcomes are visual acuity and central macular thickness. the follow-up time is 6 months.


Eligibility criteria:
inclusion criteria: * recent onset (less than 3 months) brvo exclusion criteria: * any previous intervention