Kornimate/medical-research-clean huggingface dataset:
vortioxetine for the treatment of mood and cognitive symptoms in frontotemporal dementia

Conditions: Fronto-temporal Dementia; Fronto-temporal Lobar Dementia; Frontotemporal Degeneration; Frontotemporal Dementia (FTD); Frontotemporal Dementia, Behavioral Variant; Frontotemporal Dementia

Summary: the goal of this clinical trial is to learn if vortioxetine improves mood symptoms and cognition in patients with early-stage behavioral variant frontotemporal dementia (bvftd). the main questions this study aims to answer are: 1. do individuals with mood symptoms and bvftd have brain changes and cognitive profiles that differ compared to individuals without bvftd? 2. do mood symptoms and cognition improve following treatment with vortioxetine? researchers will also determine whether there are changes in the brain associated with vortioxetine treatment. participants will: * undergo a screening visit that involves clinical assessments and laboratory tests * undergo an initial brain magnetic resonance imaging (mri) and fluorodeoxyglucose (18f) positron emission tomography (fdg pet) scan before starting treatment with vortioxetine * undergo memory and problem-solving tests before starting treatment with vortioxetine * undergo approximately 12 weeks of treatment with vortioxetine, during which time there will be regular contact and assessments with the study psychiatrist * undergo a repeat pet scan and repeat memory and problem-solving tests after 12 weeks of treatment with vortioxetine


Eligibility criteria:
ftd patients inclusion criteria: 1. male or female 2. age 45 and above 3. diagnosis of possible or probable bvftd based on international consensus criteria for behavioral variant ftd (ftdc) 4. the presence of at least one of the following affective symptoms on the 12-item neuropsychiatric inventory: depression, anxiety, irritability, or agitation 5. a global clinical dementia rating (cdr®) plus national alzheimer's coordinating center (nacc) frontotemporal lobar degeneration (ftld) behavior and language domains global score (cdr® plus nacc ftld) less than or equal to one 6. patients must be medically stable 7. vortioxetine treatment is clinically indicated 8. competent to provide informed consent exclusion criteria: 1. no history of drug or alcohol dependence within six months prior to study entry 2. negative toxicology screening for drugs of abuse 3. subject must not be pregnant or nursing 4. no contraindications to vortioxetine treatment 5. no contraindications for magnetic resonance (mr) scanning (e.g. metal implanted in the body) healthy controls inclusion criteria: 1. male or female 2. age 45 and above 3. subjects must be medically stable 4. free of psychotropic medications 5. competent to provide informed consent exclusion criteria: 1. no current or past history of neurological or psychiatric illness or substance abuse 2. subject must not be pregnant or nursing 3. negative toxicology screening for drugs of abuse 4. no contraindications for mr scanning (e.g. metal implanted in the body)

Keywords: ftd frontotemporal dementia neuropsychiatric symptoms antidepressant
clinical correlation study between anomalous pancreaticobiliary ductal junction and malignant tumors of the biliary system and the establishment of an ai-based automated recognition system

Conditions: Pancreaticobiliary Maljunction

Summary: to explore the occurrence of pancreaticobiliary maljunction (pbm) in the chinese population, the characteristics of various subtypes, and the relationship between pbm and malignant tumors of the biliary system. to explore the general clinical characteristics of patients with mild bile duct dilation but who have not been clinically diagnosed with choledochal cysts, as well as the relationship between these characteristics and malignant tumors of the biliary system. to develop and evaluate a deep learning method for machine learning of magnetic resonance cholangiopancreatography (mrcp) images, enabling fully automated detection of pancreaticobiliary maljunction.


Eligibility criteria:
inclusion criteria: cases that were hospitalized and underwent magnetic resonance cholangiopancreatography (mrcp) examination at the first medical center of chinese people's liberation army general hospital. exclusion criteria: 1. patients aged less than 18 years old; 2. those with unclear diagnosis; 3. cases with missing or poor-quality imaging data.
nordic walking and chronic low back pain

Conditions: Low Back Pain

Summary: this is a randimized clinical trial comparing the effect of supervised nordic walking versus unsupervised nordic walking versus advice to stay active


Eligibility criteria:
inclusion criteria: * finished treatment at secondary sector specialist spinal unit * able to understand and read danish exclusion criteria: * co-morbidity preventing patient from completing nordic walking program * pain \<3 on 11 point box scale * unable to perform watt max cykel test

Keywords: low back pain randomized clinical trial nordic walking supervision advice to stay active
ultrasound guided versus land-mark method for spinal anesthesia in super obesity parturients

Conditions: Obesity, Morbid

Summary: this study will investigate whether an ultrasound-assisted technique is better than a classical land-mark technique to facilitate spinal anesthesia in the sitting position in super obese pregnant women with bmi ≥ 50 who will undergo elective cesarean section. the primary objective of this study is the rate of successful dural puncture at the first attempt. it was assumed that ultrasound could facilitate neuraxial blockade in super obese (bmi ≥ 50 kg/m2), pregnant women, according to the who classification, whose topographic anatomy is difficult.

spinal anesthesia is the most commonly used anesthesia method for elective cesarean deliveries. anesthesiologists may struggle to determine the poorly palpable surface landmarks in super obese (bmi ≥ 50 kg/m2) pregnant women. the manual palpation technique, preferred in neuraxial anesthesia, may be very difficult in super obese pregnant women due to difficulty identifying bone landmarks. neuraxial ultrasound examination before spinal anesthesia may help spinal anesthesia performance and decrease the number of attempts in obese parturients. this study will be a single-center, prospective, randomized, double-blinded trial in a university hospital. patients scheduled for elective cesarean will be screened for enrollment in the study. the anesthetist administering spinal anesthesia and evaluating the data were blind to the distribution of patient groups. ultrasonographic examinations were performed by a single investigator trained in this technique who performed more than 60 ultrasound-guided neuraxial blocks.

Eligibility criteria:
inclusion criteria: * parturient who will receive selective cesarean delivery under spinal anesthesia * asa 3 scheduled for elective sections * bmi≥50 kg/m2 * normal singleton pregnancy * 37 weeks of gestation exclusion criteria: * multiple gestations * emergency c-section * exist contraindications of spinal anesthesia * local anesthetics allergy * bmi\<50 kg/m2 * history of lumbar spinal diseases and lumbar surgery * parturient refusal

Keywords: spinal anesthesia cesarean delivery ultrasound
effect of neural mobilization in bells palsy: a randomized controlled trial

Conditions: Bell Palsy

Summary: bells palsy is a sudden paralysis of half of the facial muscle. the bp is idiopathic and 70% responds well with drug therapy. there are many complementary therapies such as , tapping, electrical stimulation, and massage that adds to the recovery of condition. however, efficacy of neural mobilization in bp is not reported in the scientific literature.

bells palsy responds well with drug therapy such as prednisolone and antiviral drugs for the duration of 10-12 days. however, the administration of these drugs produce adverse side effect. therapist use a number of techniques to maintain the physiological properties of facial muscles. however, adding a new technique would add to the arsenal of techniques available for the therapist. the research is intended to determine the effect of adding neural mobilization in the recovery of bells palsy. a randomized controlled trail is intended to include 60 participants divided into two groups. experimental group will receive neural mobilization with conservative treatment and control group will receive conservative treatment only.

Eligibility criteria:
inclusion criteria: * the first episode of bell's palsy. * modified house-brackmann scale iii-iv. exclusion criteria: * diabetic * recurrent bells palsy * facial palsy * history of stroke * any cerebrovascular accident * epilepsy
combined optokinetic stimulation and cueing-based reading therapy to treat hemispatial neglect following stroke

Conditions: Spatial Neglect

Summary: spatial neglect represents a common and severe cognitive disorder following unilateral (mostly right hemisphere) stroke. patients are unaware of objects, persons and even own body parts in the (usually left) hemispace opposite to their brain lesion. while there is spontaneous remission in some patients, neglect symptoms persist in many stroke survivors which is associated with a poor functional outcome. although different therapeutic approaches (including cognitive interventions, non-invasive brain stimulation and drugs) have been investigated in the last decades, an established therapy is still missing. hence, there is a clear need for an effective and feasible intervention that can be applied in rehabilitation centers. this study is dedicated to assess the effect of a cognitive treatment consisting of combined optokinetic stimulation (oks) and cueing-based reading therapy (read) on hemispatial neglect and the neglect-related functional disability in right-hemisphere stroke patients. it will be a mono-centric, randomized, controlled, clinical trial. using a crossover design with two arms, patients will either receive the intervention therapy (oks-read) first and subsequently the control treatment (neuropsychological training not targeting visuospatial attention) or they will start in the control arm and then switch to the intervention. each treatment phase consists of 15 therapy sessions lasting 30 to 45 minutes. the outcome will be assessed at different time points, including established neuropsychological tests for spatial neglect and a clinical score of neglect-related functional disability.

see above

Eligibility criteria:
inclusion criteria: * a first-time stroke in the right hemisphere (confirmed by cranial ct or mri) within the last six months, * a left-sided hemispatial neglect (as detected in at least one subtest of the neuropsychological test battery at screening), * the ability to read and understand german language and * the ability to give informed consent. exclusion criteria: * dementia * other structural brain lesions besides the unilateral stroke (e.g. multiple or bilateral stroke lesions, hydrocephalus, inflammatory lesions, etc.) * low vision (corrected \<0.7) due to ophthalmological diseases
diagnostic accuracy of seated saline suppression test for primary aldosteronism

Conditions: Primary Aldosteronism

Summary: the present study was undertaken prospectively to compare the diagnostic significance of the seated saline suppression testing (ssst) with the captopril challenge testing (cct) in hypertensive patients with suspected primary aldosteronism (pa) using the fludrocortisone suppression testing (fst) as the reference standard, and to investigate the optimal cutoff of ssst for differentiating pa from other forms of hypertension.

the diagnosis of primary aldosteronism (pa) typically requires at least one confirmatory test. four tests are commonly recommended by the endocrine society guideline, namely, oral sodium loading, saline infusion, fludrocortisone administration with oral sodium loading, and captopril challenge testing (cct). of these, fludrocortisone suppression testing (fst) has been considered the most reliable, but is cumbersome, difficult to perform, and relatively expensive, requiring hospital admission for several days. alternative approaches to fst have included saline suppression testing (sst), which requiring patients staying in the recumbent position for at least 1 h before and during the infusion of 2 l of 0.9% saline iv over 4 h. this approach also has the disadvantages of brings much inconvenience to the patient (such as urination or defecation, etc.). ashraf h. et al. have reported that seated sst (ssst) is more sensitive than recumbent sst (rsst), especially for posture-responsive pa (95.8% versus 33.3%), however, in this small scale study, only 31 patients was pa and only three patients was tested negative for pa by fst. specificity of each form of sst was unable to estimate and meaningful receiver operating characteristic (roc) curve analyses could not be performed. furthermore, it is lack of study in chinese people. in addition, the investigators have previously found the cct was as accurate as the fst and plasma aldosterone concentration (pac) post-cct is the best approach to interpret the results of the cct. the present study was undertaken prospectively to compare the diagnostic significance of the ssst with the cct in hypertensive patients with suspected pa using the fst as the reference standard, and to investigate the optimal cutoff of ssst for differentiating pa from other forms of hypertension.

Eligibility criteria:
inclusion criteria: 1. patients with joint national commission stage 2 (\>160-179/100-109mm hg), stage 3 (\>180/110 mmhg), or drug-resistant hypertension; 2. hypertension and spontaneous or diuretic-induced hypokalemia; 3. hypertension with adrenal incidentaloma; 4. hypertension and a family history of early-onset hypertension; 5. cerebrovascular accident at a young age (\<40 years); 6. all hypertensive first-degree relatives of patients with pa. exclusion criteria: 1. heart failure; 2. chronic kidney disease with an estimated glomerular filtration rate \<30 ml/min/1.73 m2; 3. liver cirrhosis; 4. terminal malignant tumor; 5. current use of steroids or oral contraceptives; 6. pregnancy or lactation.

Keywords: saline suppression testing, seated, recumbent
age stereotype priming and social participation

Conditions: Aging Well; Memory Loss

Summary: memory performance is shown to be affected by age stereotypes among older adults. the purpose of the study is to examine the effects of age stereotype primes on episodic memory using priming intervention. the moderating effects of social participation is also examined.

all participants are community-dwelling older adults residing in hong kong. they are invited to review their social participation profile and given a brief psycho-education about memory. they are then randomly allocated to one of the two following conditions. participants are primed either with age stereotypes or non-age stereotypes words by implicit priming intervention in the context of a reaction task prior to the episodic memory tasks. other measures such as demographic variables and social participation rate are collected by questionnaire during the delayed recall interval.

Eligibility criteria:
inclusion criteria: indication of largely normal cognitive functioning as screened on the montreal cognitive assessment (moca) with hong kong norms - exclusion criteria: sensory deficits and evidence of cognitive impairment as screened on the montreal cognitive assessment (moca) with hong kong norms -

Keywords: age stereotypes episodic memory social participation
twelve week safety and efficacy study with a topical gel to treat common warts in adults

Conditions: Warts

Summary: the primary purpose of this study is to evaluate the effectiveness in adults, of four different strengths of resiquimod gel applied to common wart(s) three times a week for twelve weeks. a second purpose is to evaluate the safety of the drug.


Eligibility criteria:
inclusion criteria: * diagnosis of common warts * two forms of birth control exclusion criteria: * pregnant or breast feeding * other types of wart(s), ie. plantar * currently participating in another clinical study * chronic viral hepatitis b or c

Keywords: wart(s) adults common wart(s)
drug provocation test (dpt) to non steroidal anti-inflammatory drugs (nsaid)

Conditions: Drug Hypersensitivity

Summary: background : non steroidal anti-inflammatory drugs are responsible for 25% of reported adverse drug events which include immunological and non-immunological hypersensitivity reactions. nsaids have been reported to be the second most common cause of drug-induced hypersensitivity reaction (dhr). they are almost mandatory in a human life and therefore, the drug allergy work-up goes up until a dpt in order to confirm or rule out the diagnosis. objective: detect eliciting dose thresholds during nsaids dpt in order to suggest optimal step doses and to describe subgroups at higher risk during the dpt methods:this retrospective study, using the survival analysis, comprised all patients who attended the allergy service of the uh of montpellier from 1997 till 2017 with a clinical history related to nsaids dhr, who underwent ndaids dpt that turned positive and who gave their consent to be included in the study . the patients are selected from the drug allergy \& hypersensitivity database (dahd).

dhrs to nsaids may be induced by both specific immunological mechanisms and mechanisms not based on immunological recognition (cross-hypersensitivity reactions \[crs\]) .they are almost mandatory in a human life and therefore, the drug allergy work-up goes up until a dpt in order to confirm or rule out the diagnosis. although the overall prevalence of nsaid hypersensitivity has been reported between 0.6 and 7% of the general population . the nsaids-induced hypersensitivity reactions involve different mechanisms and present a wide range of clinical manifestations from anaphylaxis or severe bronchospasm developing within minutes after drug ingestion to non-immediate responses appearing after days and weeks this data-driven approach in designing the dpt protocol is the second step in improving dpt standardization, after bl antibiotics.

Eligibility criteria:
inclusion criteria: - patients with one or more positives dpt to nsaids exclusion criteria: - patients refusing to take part in the study

Keywords: drug hypersensitivity reaction drug provocation test non steroidal anti inflammatory drugs reactive doses reactive times
sacubitril/valsartan versus valsartan in heart failure

Conditions: Heart Failure

Summary: the objective of this study was to identify potential prognostic factors of sacubitril/valsartan vs valsartan treatment response.

study will include 80 symptomatic patients with chronic hfref (left ventricular ejection fraction ≤35%) and new york heart association (nyha) class ii/iii: group 1 (n = 40) received sacubitril/valsartan (target dose, 100 mg twice daily) or group 2 received valsartan (target dose, 80 mg twice daily) in addition to recommended therapy according to physician's judgment. analysis of biochemical parameters, cardiopulmonary exercise testing, and echocardiographic evaluation was performed at baseline and 6 months later. the primary outcome was the change in lvef%, lipo a, troponin i, nt-pro bnp and neopterin levels. the secondary outcome is reporting efficacy and safety of sacubitril/valsartan vs valsartan use and the relationship between nyha and ef and biomarkers.

Eligibility criteria:
inclusion criteria: * patients with hf were enrolled if aged \> 35 years, * stable symptomatic systolic chronic hf (≥ 4 weeks), with left ventricular ejection fraction (lvef) \< 35%, * nyha class ii-iii, * sinus rhythm and resting hr ≥ 70 beats/min on optimised standard medical therapy. exclusion criteria: * patients with acute decompensation, * cerebrovascular events during the previous 6 months, * pregnancy, breastfeeding, * any valve dysfunction/abnormality, * active myocarditis, * second-degree and third-degree atrioventricular block, * sick sinus syndrome.

Keywords: lvef%, lipo a, troponin i, nt-pro bnp, neopterin
comparison of 3 methods to diagnose endolymphatic hydrops in meniere's disease

Conditions: Endolymphatic Hydrops

Summary: the aim of this study is to compare 3 methods for the diagnosis of endolymphatic hydrops (eh) in patients with meniere's disease: mri 3 tesla (to visualise eh directly), and functional explorations, namely electrocochleography and dephasing of acoustic distortion products (which are modified by the eh). the research hypothesis is that the examinations will show agreement in the diagnosis of eh, and that the results obtained (quantitative values) will vary in the same direction over time and during flares of md.


Eligibility criteria:
inclusion criteria: * persons who have provided written consent * persons aged 18 to 75 years * persons with certain, probable or possible meniere's disease according to the international classification aao-hns exclusion criteria: * persons without health insurance cover * adults under guardianship * persons with a history of hypersensitivity to the active substance or to one of the excipients of the contrast agent used for the mri or to any gadolinium chelate * pregnant or breast-feeding women * severe acute or chronic kidney failure * other identified causes of cochleo-vestibular syndromes * impossibility to follow-up or carry out any of the examinations necessary for the protocol