Kornimate/medical-research-clean huggingface dataset:
a study measuring substances potentially indicating bone problems in adults with type 1 gaucher condition

Conditions: Gaucher Disease

Summary: substances in the body, so-called biomarkers, can help predict the severity of gaucher disease (gd)-related bone problems in adults. the main aim of the study is to determine if certain biomarkers found in the body at the time of diagnosing gd can help predict the risk of bone problems after 4-5 years. there is no treatment involved in this study. the study will review previously collected participants' data using a database. data from both adults with type 1 gaucher condition as well as healthy adults will be compared.

this is a non-interventional and retrospective study of participants with gd1 and healthy participants whose data is available in the aragon health systems biobank (bssa) from the date of diagnosis to 4-5 years after diagnosis. the main objective of this study is to validate the prognosis value of a set of potential biomarkers related to bone disease in participants with gd1. the study will enroll approximately 120 participants, and it would be divided into 4 groups as given below: * group a: gd1 with low-normal bone disease * group b: gd1 with mild bone disease * group c: gd1 with severe bone disease * group d: healthy participants this study will have a retrospective data collection from the date of diagnosis of gd1 until 4-5 years from diagnosis by using data available in bssa. this single-centre trial will be conducted in spain. the overall time for data collection in this study will be approximately 9 months.

Eligibility criteria:
for participants with gd1: inclusion criteria * participants with confirmed diagnosis of gd1. * determination of glucocerebrosidase (gcase) blood activity at diagnosis of gd1. * dna analysis result demonstrating pathogenic variants in the glucocerebrosidase gene (gba1) gene. * available data of clinical state at diagnosis and at 4-5 years from diagnosis, including s-mri, dual energy x-ray absorptiometry (dxa), and gd1 severity scoring system (gd1-ds3) indexes (or data to calculate it). exclusion criteria • evidence of hepatitis b, hepatitis c infection or other chronic infectious diseases. for healthy volunteers exclusion criteria * evidence of hepatitis b, hepatitis c infection or other chronic infectious diseases. * evidence of bone disease.

Keywords: drug therapy
project gullstrand - european project for the determination of average biometric values of human eyes

Conditions: Normal Subjects, Ametropia

Summary: the purpose of this study is to determine the average values of human ocular biometry and to correlate these values with visual function.


Eligibility criteria:
inclusion criteria: * two normal eyes * ametropia between -10d and +10d. exclusion criteria: * one pathological eye * prior ocular surgery * amblyopia, refraction larger than ±10d * corneal or retinal pathologies * systemic diseases (e.g. diabetes, multiple sclerosis, ...) * more than 5 months pregnant at the moment of testing * recent wear of hard contact lenses * epilepsy (if c-quant is used).
respiratory variations for assessing blood withdrawal

Conditions: Genetic Hemochromatosis

Summary: objectives: to investigate whether respiratory variations of the inferior vena cava (δivc) and internal jugular vein (δijv) diameters during standardized breathing (δivcst and δijvst) increase after a therapeutic bleeding in spontaneously breathing and non-obese patients with genetic hemochromatosis. design: prospective, monocentric study in the efs nord-de-france blood center. patients: non-obese patients with genetic hemochromatosis undergoing a therapeutic bleeding. interventions: ultrasound measures and collected clinical parameters before and after a therapeutic bleeding, during a standardized respiratory maneuver. main outcome and measures: the primary endpoint was the δivcst change induced by a 300 to 500ml therapeutic bleeding. it measured the minimal and maximal ivc and ijv diameters during a standardized respiratory maneuver. δivcst and δijvst were calculated as follows: \[(maximal diameter - minimal diameter)/maximal diameter\].100.


Eligibility criteria:
inclusion criteria: * adult patients of \> or equal 18 years * genetic hemochromatosis * undergoing a therapeutic blood withdrawal * health insured * non-obese (body mass index \<30kg/m²) exclusion criteria: * pregnancy * transthoracic echogenicity unsuitable for measuring the inferior vena cava diameters * clinical signs of active exhalation

Keywords: hemochromatosis blood withdrawal respiratory variations inferior vena cava internal jugular vein ultrasound ultrasonography echography
pilot study for the evaluation of the more stamina in persons with multiple sclerosis

Conditions: Multiple Sclerosis; Fatigue; Chronic Conditions, Multiple

Summary: the overall study aims are to explore the feasibility, acceptability, and usability of more stamina, a mobile app for fatigue self-management for persons with ms.

multiple sclerosis (ms) is one of the world's most common neurologic disorders of the young adults leading to severe disability. fatigue is one of most common symptoms that persons with ms experience, having significant impact on their quality of life and limiting their activity levels. self-management strategies are used to support them in the care of their health. mobile health (mhealth) solutions are a way to offer persons with chronic conditions tools to successfully manage their symptoms and problems. user-centered design (ucd) is a design philosophy that proposes placing end-users' needs and characteristics in the center of software design and development and involving users early in the different phases of the software life cycle. more stamina is an mhealth solution created following ucd principles to help persons with ms manage their fatigue. a mixed methods study was used to assess the feasibility, acceptability, and usability of more stamina. the study took place between january and march of 2023 in finland. a longitudinal cohort study took take place, along with think-aloud protocols, open-ended interviews and short answer questionnaires. the study enrolled 20 persons with ms that met the criteria who utilized the more stamina solution for 60 days.

Eligibility criteria:
inclusion criteria: * be over 18 years old; * have a confirmed ms diagnosis (including secondary, relapsing and progressive ms) for at least 1 year, * have none to moderate physical disability (edss \< 6.5) at the time of recruiting; * no major cognitive or haptile impairment influencing the ability to use the app; * own a compatible smartphone device; exclusion criteria: * refusal to participate or the informed consent process; * objective cognitive impairment that hinders the use of mobile applications; * physical or cognitive impossibility to use the visual interface of mobile applications; * difficulties in access or availability for full attendance at the 3 encounters of the study.

Keywords: ehealth mhealth gamification
clinical and instrumental treatment's predictors in subjects with neurological diseases using g-eo robotic system

Conditions: Multiple Sclerosis; Stroke; Parkinson Disease; Acquired Brain Injury

Summary: the aim of this work is to elaborate a statistical model to predict the effectiveness of robotic treatment in subjects with neurological diseases. the model will be used to understand which subjects are most responsive to this type of treatment

in recent years, robotic devices have been used to assist balance and gait rehabilitation of people with neurological disorders. in particular, the g-eo system (reha technology ag, switzerland) is a robotic end-effector device guiding the movement of the feet. it is currently unclear which variables are the predictors of treatment success. indeed, the effectiveness of the geo treatment may depends on the characteristics of the treatment itself (instrumental parameters defined by the physiotherapist using the device) and on the characteristics of the subject receiving the treatment. therefore, it is necessary to measure these clinical and instrumental characteristics to understand which are predictors of treatment effects. parameters obtained from this assessment can be used to elaborate statistical models. in our study the statistical model will be defined as follows: the change in the primary outcome measure after the robotic treatment will be considered as dependent variable of the model. all the "secondary" clinical outcome measures will be measured only at t0 and will be considered in the model as independent variables, along with the participants characteristics (age, gender, disease, disease duration, falls number, numbers of comorbidity, type of hospitalization) and the treatment characteristics (sessions number, frequency, duration, step length, cadence, gait speed, body weight support, distance traveled). the results of the model will suggest which subjects are most responsive to this type of treatment and which variables can be considered as predictors of the treatment success.

Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis, parkinson disease, stroke or acquired brain injury * minimum number of sessions: 10 sessions with the geo system * minimum frequency of sessions: 2 per week * age ≥ 18 years * ability to walk for at least 10 meters, also with aid * indication of robotic treatment in the therapeutic plan * body size suitable for the robotic device * ability to maintain verticality for 7 minutes; * ability to maintain the sitting position without support for 30 seconds; exclusion criteria: * severe limitations of articular range of motion; * medical problems compromising walking (e.g. fractures, pain, severe osteoporosis or severe spasticity); * presence of skin lesions in the areas of contact with the device; * presence of seizures that may be triggered by the use of the g-eo system.

Keywords: multiple sclerosis stroke parkinson disease acquired brain injury robotic end-effector
clinical investigation on the effects of bayberry juice treatment in adult subjects with features of fatty liver disease

Conditions: Nonalcoholic Fatty Liver Disease

Summary: chinese bayberry, one of six myrica species native to china, is rich in anthocyanins, and cyanidin-3-o-glucoside (c3g) was identified as a major anthocyanin component. in previous animal studies from us and other investigators, anthocyanins have been shown to ameliorate dyslipidemia and hepatic steatosis in different rodent models. the aim of the present study was to examine the effects of chinese bayberry juice (cbj) on the serum lipid profile and on levels of biomarkers related to antioxidant status in young adults with features of fatty liver disease.


Eligibility criteria:
inclusion criteria: * subject inclusion criteria were age 18-25 y, * bmi \[body weight divided by height squared (in kg/m2)\] \> 23, * lack of excessive alcohol ingestion confirmed by careful questioning by the primary physician and dietitians (consumption of less than 70 g alcohol in female and 140 g in male per week), and * the presence of two of the three following diagnostic criteria of the fatty liver disease: increased hepatic echogenicity compared to the spleen or the kidneys, blurring of liver vasculature and deep attenuation of the ultrasonographic signal. exclusion criteria: * overuse of alcohol, * viral hepatitis, * type 1 or 2 diabetes, * gastrointestinal or connective diseases, * chronic pancreatitis, * liver cirrhosis, * kidney stones, or renal failure; * use of acetyl-salicylic acid or other antiplatelet drugs, statins of fibrates, oral hypoglycemic drugs, nitrates, nonsteroidal antiinflammatory drugs, corticosteroids, or drugs interfering with coagulation; * supplementation with vitamins or antioxidants.

Keywords: oxidative stress dyslipidemia inflammation
safety study of aro spinal system as an adjunct to lumbar decompression

Conditions: Lumbar Disc Prolapse With Radiculopathy

Summary: to evaluate the clinical safety and effectiveness of the aro spinal system and to assess preliminary cost/benefit analysis in patients undergoing decompression surgery for symptomatic lumbar disc herniations. the general hypothesis is that the aro significantly improves outcomes in patients undergoing decompression surgery for symptomatic lumbar disc herniations.

not provided

Eligibility criteria:
inclusion criteria: 1. radicular pain and evidence of nerve-root irritation lasting 6 weeks or more as evidenced by both: 1. radicular pain - below the knee, 2. nerve root irritation i. positive nerve root tension sign - straight leg raise positive between 30 and 70 degrees, or ii. positive femoral tension sign, or iii. neurologic deficit - asymmetrical depressed reflex or decreased sensation in a dermatomal distribution or weakness in a myotomal distribution. 2. primary one-level posterolateral herniation in the lower lumbar spine (l4-l5 or l5-s1 only) as shown by magnetic resonance (mr) imaging (protrusion, extrusion or sequestered fragment) consistent with the clinical symptoms (both level and side). 3. the investigator confirms that the patient is a surgical candidate for discectomy, 4. the patient has been scheduled for their surgical procedure no more than two months from time of consent, 5. 18 years to 55 years of age at time of consent, 6. willing to complete the study requirements and permit agency and sponsor authorized personnel to access medical records, 7. able to understand oral and written danish. exclusion criteria: 1. previous lumbar surgery 2. cauda equine syndrome 3. scoliosis greater than 15 degrees 4. osteoporosis 5. segmental instability (\> 10 degrees angular motion or \>4mm translation) 6. vertebral fractures 7. spinal infections 8. spinal tumors 9. inflammatory spondyloarthropathy 10. pregnancy or the intent to become pregnant in the following year 11. comorbid conditions contraindicating surgery 12. multiple herniations 13. known allergy to titanium, aluminum or vanadium 14. female patients of childbearing age, who are not willing to use adequate contraception specified as: intrauterine devices, hormonal contraceptives (contraceptive pills, implants, transdermal patches, hormonal vaginal devices or injections with prolonged release). it is accepted in certain cases to include subjects having a sterilized permanent partner or subjects using double barrier contraceptive methods which is a condom combined with a diaphragm.
removable titanium clip treatment for acute variceal hemorrhage from the gastric fundus

Conditions: Gastric Variceal Bleeding

Summary: removable titanium clip treatment for acute variceal hemorrhage from the gastric fundus

during the procedure, a removable titanium clip was used to block the bleeding vessels, enabling rapid hemostasis. five days later, secondary preventive measures such as eci or tips were performed. the titanium clip was removed during or after the procedure, avoiding its retention in the body, which could interfere with subsequent mri examinations and related treatments. in situations where emergency eci or other treatments are not feasible, this method can serve as a 'temporary bridge' for the treatment of acute gastric fundal variceal hemorrhage, potentially saving the patient's life.

Eligibility criteria:
inclusion criteria: 1. the patient and their family agree to and sign the relevant informed consent form. 2. diagnosed with cirrhosis based on clinical manifestations, laboratory tests, imaging findings, or pathological examinations. 3. history of symptoms related to variceal upper gastrointestinal bleeding, such as hematemesis, melena, or rectal bleeding. 4. patients confirmed by endoscopy to have bleeding from ruptured gastric varices. 5. patients who are hemodynamically stable before or after initial fluid resuscitation. 6. aged 18 to 75 years. exclusion criteria: 1. those with concomitant bleeding from ruptured esophageal varices. 2. a history of gastrointestinal-related surgical procedures. 3. individuals with altered consciousness who are difficult to treat. 4. those with concomitant malignant tumors. 5. individuals with serious diseases involving the heart, brain, lungs, or kidneys. 6. pregnant and breastfeeding women. 7. those with contraindications to relevant treatments.

Keywords: a removable titanium clip
transplantation of neural stem cell-derived neurons for parkinson's disease

Conditions: Parkinson's Disease

Summary: this is a prospective study to demonstrate the safety and efficacy of differentiated neurons-derived from adult cns progenitors cells transplanted in selected patients with parkinson's disease.


Eligibility criteria:
inclusion criteria: 1. able to give informed consent prior to study 2. male or female with diagnostic criteria of parkinson's disease 3. age 35 to 85 years old 4. parkinson's disease not due to trauma, infection, brain tumor, cerebrovascular disease 5. hoehn and yahr stage iii or iv 6. parkinson's disease observed in the absence of: * oculomotor palsy * cerebellar sign * orthostatic hypotension (drop greater than 20mmhg in mean pressure) * pyramidal sign * amyotrophy 7. good general health or stable medical condition well controlled, without contraindications to anesthesia exclusion criteria: 1. patients with severe dementia and brain atrophy on mri 2. patients with severe hypertension; renal, liver, cardiac or other major organ disease; coagulopathy; cancer; other significant systemic illnesses; hepatitis, hiv 3. patients older than 85 or younger than 35 4. patients who withhold informed consent 5. patients with a history of alcohol or drug abuse 6. sexually active women of childbearing potential without adequate form of birth control 7. evidence of abnormal coagulation or anticoagulant therapy 8. pregnancy or lactation 9. history of seizure disorders or current use of antiepileptic medication 10. severe cognitive impairment 11. clinically significant laboratory abnormality
a new way of cardiac denervation to reduce the incidence of af after cabg.

Conditions: Cardiac Denervation; Postoperative Atrial Fibrillation

Summary: this is a prospective, random controlled trial(rct) study. 430 patients undergoing coronary artery bypass grafting were enrolled. our new way of cardiac denervation, defined as excision of marshall ligament and waterstone fat pad, was performed in 215 patients, and the other 215 patients were used as control subjects. all the patients need to equip with electronic monitor to record heart rhythms within 6 days after cabg. the investigators will compare the incidence of postoperative atrial fibrillation between two groups, and follow up 30 days after discharged.


Eligibility criteria:
inclusion criteria: 1. patients undergoing simple cabg (on-pump/off-pump) for the first time. 2. patients who signed the informed consent form and willing to undergo cardiac denervation. exclusion criteria: 1. age \< 18； 2. emergent cabg; 3. cardiac surgery history； 4. receiving other cardiac surgery except of cabg at the same time, such as morrow、valvular surgery、ventricular aneurysm surgery、congenital heart diseases surgery； 5. requiring mechanical or pharmacological therapy for hemodynamic support before cabg, such as ecmo or iabp; 6. history of af ; 7. taking antiarrhythmic agents except of beta-blockers last 2 weeks.
randomized trial of eus-guided gastrojejunostomy and surgical gastrojejunostomy in gastric outlet obstruction

Conditions: Gastric Outlet Obstruction

Summary: malignant gastric outlet obstruction (goo) results from the mechanical obstruction of the duodenum or distal stomach from an underlying cancer. the aim of this study is to compare the clinical outcomes between surgical gastrojejunostomy and eus-guided gastrojejunostomy in patients with malignant gastric outlet obstruction.

malignant gastric outlet obstruction (goo) results from the mechanical obstruction of the duodenum or distal stomach from an underlying cancer. the consequences of goo are abdominal pain, nausea, vomiting, anorexia, inability to maintain an oral diet and weight loss, with associated poor quality of life and inability to continue with cancer therapy. the aim of this study is to compare the clinical outcomes between surgical gastrojejunostomy and eus-guided gastrojejunostomy in patients with malignant gastric outlet obstruction.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. presence of gastric outlet or duodenal obstruction on any imaging or endoscopy from known or suspected inoperable malignancy 3. gastric outlet obstruction scoring system (gooss) of ≤ 1 (defined as maximum oral intake of liquids only) 4. amenable to treatment by both eus-guided and surgical gastrojejunostomy exclusion criteria: 1. age \< 18 years 2. intrauterine pregnancy 3. use of anticoagulants that cannot be discontinued for the procedure or irreversible coagulopathy 4. unable to obtain consent for the procedure from either the patient or lar 5. altered anatomy due to prior gastroduodenal surgery 6. presence of other adhesions or synchronous obstructive lesions in the small bowel 7. prior treatment for gastric outlet obstruction 8. presence of large volume malignant ascites

Keywords: gastric outlet obstruction endoscopic ultrasound surgery malignancy gastrojejunostomy
the effectiveness of the massage and the hypopressive abdominal gymnastics on low back pain (mas-gah)

Conditions: Low-back Pain

Summary: the main goal of this study is to get to know if applying both, massotherapy plus hypopressive abdominal gymnastics (h.a.g) will reduce the pain of chronic non-specific low back pain. it actually reduces the inability produced by the pain and improve the patient's quality of life as well as the join range of the lumbar spine, way more than these two therapies applied separately.

background: back pain is one of the most common musculoskeletal disorders in the industrialized society. it is estimated to affect between 70 to 85% of the adult population over their live. the impact of low back pain is widespread in developed countries, and accounts the major spending in economic and health resources, as well as being associated with the leading causes of absenteeism and disability. diagnosis, in most cases, nonspecific low back pain, the symptoms have no clear cause, so that the source of pain is unknown. in general, a significant percentage progresses to chronic back pain and is accompanied by a limitation of physical activity influenced by improper posture or movement patterns. objectives: to assess the effectiveness of massage therapy and hypopressive abdominal gymnastics, and the combination of both therapeutic modalities, to decrease pain and lumbar disability; and increasing joint mobility and quality of life in patients with chronic nonspecific low back pain.

Eligibility criteria:
inclusion criteria: * patients with chronic non-specific low back pain diagnosed and at least 12 weeks of mechanical pain. exclusion criteria: * patients: * with arterial hypertension diagnosed. * with progressive neurological deficits. * pregnant or suspect that they are pregnant. * with psychological or psychiatric process diagnosed. * under analgesic treatment.

Keywords: low-back pain massage therapy gymnastics disability