Kornimate/medical-research-clean huggingface dataset:
effect of lower leg heating and transcutaneous electrical nerve stimulation on exercise capacity in patients with pad

Conditions: Peripheral Arterial Disease

Summary: peripheral arterial disease (pad) is characterized by poor circulation in the lower extremities that often provokes claudication (leg pain, numbness, and heaviness) with physical exertion. the aim of this research protocol is to determine the effect of two non-invasive treatment modalities on leg blood flow and exercise capacity in those with pad. specifically, we are measuring popliteal artery blood flow (doppler ultrasound), toe oxygen saturation, ankle-brachial index (abi), and 6-minute walking distance (6mwd) in men and women who have intermittent claudication (fontaine stage ii; rutherford category 1-2) in response to 15 or 45 minutes of lower limb heating and transcutaneous electrical nerve stimulation (tens).


Eligibility criteria:
inclusion criteria: * intermittent claudication (fontaine stage ii) * resting ankle-brachial index (abi) \< 0.90 * ability to walk \> 60 meters in six minutes exclusion criteria: * body mass index (bmi) \> 35 kg/m2 * severe exercise limitations (more than pad) due to co-morbidity * taking illegal/recreational drugs * uncontrolled hypertension (\>180/100 mmhg) * severe peripheral neuropathy * foot ulcers * gangrene * pregnant or breast feeding
incidence of iron deficiency anemia in toddlers

Conditions: Healthy Infants

Summary: the frequency of iron deficiency anemia was extensively studied in infants on the first year of life. there is not enough information about the frequency of iron deficiency during the second and third years of life. in a previous study performed in israel and published in pediatrics 2006 the incidence of anemia does not decrease towards age 18 months. then there is reasonable to study the iron deficiency frequency beyond this age.

the purpose of this study is to analyze the frequency of iron deficiency anemia in a group of 400 toddles from age 18 months to 36 months. two groups of children will be included, 200 children from jewish origin and 200 from non jewish origin, mostly arabs. a questionnaire that included demographic characteristics, nutrition and iron supplementation in the first year, growth status, and laboratory results will be filled for each patient. the laboratory analysis will include complete blood count and serum ferritin analysis. children that were previously diagnosed suffering from iron deficiency, children suffering from chronic diseases or were born premature will not be included in the study.

Eligibility criteria:
inclusion criteria: * healthy children that attend the pediatric community clinics. exclusion criteria: * children that were previously diagnosed suffering from iron deficiency. * children suffering from chronic diseases or were born premature will not be included in the study.

Keywords: infants iron deficiency anemia healthy infants that attend the pediatric community clinics
survival trends in myocardial infarction 1994 - 2010

Conditions: Myocardial Infarction

Summary: practice in management of myocardial ischemia and infarction has changed significantly over the past 20 years, both in terms of immediate management and secondary prevention. the aim of this observational study is to utilize the established record linkage data available in tayside to investigate the trends in survivors of myocardial infarction in tayside since 1994.


Eligibility criteria:
inclusion criteria: * myocardial infarction exclusion criteria: * nil
differential diagnosis between granuloma and radicular cyst: effectiveness of magnetic resonance imaging.

Conditions: Periapical Diseases

Summary: the radiolucent periapical jaw lesions of 34 patients, which were surgically enucleated, were investigated by two radiologists using mri, based on the same six criteria, to categorize the lesions as granulomas or radicular cysts. after apicoectomies, two oral pathologists (blinded to the radiologist's diagnoses) analyzed all specimens by referring to seven specific parameters and diagnosed the specimens as granulomas or radicular cysts. the inter-rater agreements between the radiologists and pathologists in terms of mri and histological diagnoses, respectively, along with the discriminant power of the adopted criteria and the accuracy of the mri assessments compared with the histopathologic results, were calculated. a strong inter-rater reliability was observed between the two radiologists (k-statistic = 0.86, p = 0.0001) and the two pathologists (k-statistic = 0.88, p = 0.0001). reliability was higher for the radiological (guttmann's lambda lower bound \> 0.6) than histopathological criteria. the accuracy (true positives plus true negatives) of the radiologists was higher than that of the pathologists based on receiver operator characteristic analysis (area under the curve = 0.87 and 0.91, respectively). mri reliability and accuracy were high and comparable to histopathological reliability, highlighting the usefulness of this non-invasive exam as a pre-treatment diagnostic method for periapical endodontic lesions.


Eligibility criteria:
inclusion criteria: * patient age ≥ 18 years * the diameter of the lesion ≥ 5 mm, assessed based on periapical x-ray, * an acceptable endodontic treatment for the involved tooth. exclusion criteria: * general medical contraindications for classification of the patient as level iii or higher according to the american society of anesthesiologists, * teeth involved in the lesion, the function of which could not be salvaged after enucleation of the lesion and apicoectomy. the radiological exclusion criteria were * contraindication undergoing magnetic resonance: presence of a pacemaker or any metallic devices that could interfere with the magnetic field; * severe claustrophobia, * weight ≥ 130 kg * intolerance to gadolinium-dtpa as a contrast agent;
deep learning with mri-based multimodal-data fusion enhanced postoperative risk stratification of breast cancer

Conditions: Breast Cancer

Summary: breast cancer poses a significant global health challenge, especially among women, with high rates of recurrence and distant spread despite early interventions. the timely identification of metastasis risk and accurate prediction of treatment strategies are critical for improving prognosis. however, the complex heterogeneity of breast tumors presents challenges in precise prognosis prediction. therefore, the development of innovative methods for tumor segmentation and prognosis assessment is essential. the research conducted is a multicenter study that enrolled 1,199 non-metastatic breast cancer patients from four independent centers. our study leverages the advancements in artificial intelligence (ai) to address this challenge. this study is the first successful application of mri-based multimodal prediction system to precisely identify the risk of postoperative recurrence in breast cancer patients.


Eligibility criteria:
inclusion criteria: * histologically confirmed stage i-iii invasive bc * age ≥ 18 years * the patient having undergone surgery * the existence of mri scans exclusion criteria: * lacked pathological results * had other, simultaneous malignancies * had mr imaging issues were excluded

Keywords: deep learning
nudges for statin prescribing in primary care

Conditions: Cardiovascular Diseases

Summary: the objective of the study is to evaluate the effect of nudges to clinicians, patients, or both to initiate statin prescriptions for patients that meet national guidelines.

cardiovascular disease (cvd) is the leading cause of mortality in the united states. statins have been demonstrated to be an effective tool for reducing the risk of cvd-related events and mortality, but statins are often not prescribed for patients that meet evidence-based guidelines. in this study, the investigators will evaluate nudges to clinicians, patients, or both to initiate statin prescriptions for patients that meet the united states preventive task force guidelines, patients with clinical atherosclerotic cardiovascular disease (ascvd) condition, and patients with a history of familial hyperlipidemia. in partnership with the health system, this will be conducted as a 4-arm factorial, cluster randomized trial to evaluate the effect of the interventions.

Eligibility criteria:
inclusion criteria: 1. have new or return visit with a primary care provider at one of the study practices at the university of pennsylvania health system 2. either have an ascvd condition, history of familial hyperlipidemia, or meet united state preventive task force guidelines for statin therapy which includes age 40-75 years, at least 1 cardiovascular risk factor (e.g. dyslipidemia, diabetes, hypertension, smoking), 10-year asvcd risk score ≥ 10% exclusion criteria: 1. already prescribed a statin 2. allergy to statins 3. severe renal insufficiency defined as glomerular filtration rate (gfr) less than 30 ml/min or on dialysis 4. adverse reaction to statins including statin-related a) myopathy; b) rhabdomyolysis; c) hepatitis 5. pregnant 6. currently breastfeeding 7. on hospice or at the end-of-life 8. on a pcsk9 inhibitor medication clinicians (and their respective patients) will be excluded if they have less than 10 patients among their entire panel that are eligible for a statin medication.

Keywords: statin
imaging outcomes of cognitive behavioral therapy (cbt) for battered women with posttraumatic stress disorder

Conditions: Posttraumatic Stress Disorder

Summary: identifying neural mechanisms of posttraumatic stress disorder (ptsd) treatment could help elucidate reasons for variable treatment response and identify novel treatment targets. exposure-based therapies have been associated with decreased amygdala and increased cingulate cortex response during emotional processing. the current study examined whether cognitive therapy for ptsd in women reduces activation in insula and amygdala and enhances activation in prefrontal regions during emotional anticipation and pre-treatment prefrontal activation predicts treatment response.


Eligibility criteria:
inclusion criteria: * female. * intimate partner violence (ipv) trauma defined as physical and/or sexual abuse committed by a romantic partner, occurring within five years of, but having ended at least one month prior to, enrollment in the study. * seeking treatment for posttraumatic stress disorder (ptsd) symptoms and meeting full or partial diagnostic and statistical manual, 4th edition (dsm-iv) criteria for ptsd prior to treatment, verified through the clinician-administered ptsd scale (caps). exclusion criteria: * substance abuse in the past year * history of \>2 years of alcohol abuse * use of psychotropic medications within 4 weeks prior to the study, bipolar disorder or schizophrenia, irremovable ferromagnetic bodily material, pregnancy, or claustrophobia.

Keywords: ptsd domestic violence intimate partner violence functional mri neuroimaging
impact of preoperative chemotherapy on complications and regeneration after resection of colorectal liver metastases

Conditions: Colorectal Liver Metastases

Summary: the objective of this study is to evaluate for the first time not only the impact of neoadjuvant chemotherapy on clinical outcome, but also on liver regeneration after liver resection.


Eligibility criteria:
inclusion criteria: * liver resection due to colorectal liver metastases between 2003 and 2007 exclusion criteria: * incomplete assessment of preoperative chemotherapy

Keywords: neoadjuvant chemotherapy clinically postoperative outcome liver regeneration after liver resection
positive effects of laser acupuncture in methamphetamine users undergoing group cognitive behavioral therapy: a pilot study

Conditions: Substance Abuse

Summary: methamphetamine (ma) addiction has become a crucial public health issue due to its adverse effects. acupuncture has been used for drug detoxification for many years. however, some disadvantages are not be suitable for ma users. the advantages of laser acupuncture includes safety, painless, less time consuming and higher acceptability without current investigation. therefore, investigators arrange this study to evaluate the efficacy of laser acupuncture combined with golden treatment of cognitive group therapy.

methamphetamine (ma) addiction has become a crucial public health concern because of its adverse consequences to individuals and the society. manual or auricular acupuncture have been applied in opioid dependence treatment for a long time. electroacupuncture may also alleviate the symptoms of ma addiction such as psychosis, anxiety, and depression during abstinence. however, several comorbidities are associated with ma use, such as blood-borne infections, decreased the willingness of physicians to perform. the advantages of laser acupuncture (la) include its safety, painlessness, limited time use, and higher acceptability, making it suitable for treatment of drug users. to investigate the clinical efficacy of laser acupuncture combined with group cognitive behavioral therapy for ma addiction treatment. ma users who participated in group cognitive behavioral therapy and met the inclusion criteria were referred from psychiatrists to participate. the participants received laser acupuncture treatment once a week for 2 months (total eight treatments) on selected acupoints (pc6, ht7, li4, st36, sp6, and lr3). laboratory assessment included urinalysis for ma and liver function tests aspartate aminotransferase, alanine aminotransferase, and γ-glutamyltransferase (ast, alt, and r-gt), whereas the objective assessment included visual analog scale (vas) for ma craving and refusal and pittsburgh sleep quality index (psqi), beck anxiety inventory (bai), and beck depression inventory (bdi) questionnaires. all data were collected before and at 1 and 2 months after treatment. cognitive behavioral therapy completion rate and rate of relapse to ma use were also determined.

Eligibility criteria:
inclusion criteria: * subject must be aged ≥20 years, with full understanding of the content of the study and who signed a consent form * subject must be diagnosed as ma use disorder by a psychiatrist according to the diagnostic and statistical manual of mental disorders, fifth edition (dsm-v) * subject must participate in cognitive behavioral therapy exclusion criteria: * subject received manual acupuncture or la treatment in the preceding month * subject had cancer, stroke, myocardial infarction, or major trauma * subject demonstrated obvious suicide intention * subject were pregnant * subject were hiv-positive

Keywords: substance abuse methamphetamine addiction laser acupuncture
sexual dysfunction and dental care

Conditions: Dyspareunia; Hypoactive Sexual Desire Disorder; Erectile Dysfunction; Vaginismus

Summary: evaluation of sexual functioning of patients at the sexual medical center, at sheba medical center in israel. sexual functioning shall be compared with their dental behavior. hypothesis: a positive association will be found.

patients, male and female, age over 18, who apply to the sexual medical center, at sheba medical center will fill a battery of questionnaires regarding their sexual function and dental treatment.

Eligibility criteria:
inclusion criteria: * men and women, over 18 years old, who come for sexual therapy/ counseling to the sexual medical center, in sheba medical center, israel partners or spouses of the above. exclusion criteria: * patients who are already in the middle of treatment.

Keywords: sexual dysfunction male female dental care need of control
pilot study of rituximab therapy for systemic lupus erythematosus (sle) and vasculitis

Conditions: Systemic Lupus Erythematosus; ANCA Associated Vasculitis

Summary: lupus and vasculitis are autoimmune conditions which can be life threatening. in order to treat these conditions toxic therapies such as cyclophosphamide and steroids are often required. these standard treatments are associated with significant side effects. furthermore a proportion of patient do not respond to these conventional therapies. newer safer therapies are being sought. rituximab is a drug that eliminates b cell from the blood. b cells are one part of the human immune system that helps prevent infections. abnormal activity of the immune system is responsible for autoimmune disease although the exact mechanisms in lupus and vasculitis are not yet established. rituximab is liscenced as a treatment for a form of b cell cancer called non-hodgkins lymphoma and has a good safety track record when used in this context. it has recently been used to treat some autoimmune conditions with positive results. in this pilot study we wish to assess the effectiveness and safety of rituximab in patients with lupus and vascultis that are resistant to conventional therpies.


Eligibility criteria:
inclusion criteria: 1. diagnosis of sle or anca associated vasculitis 2. active disease refractory to 6 months conventional therapy with cyclophosphamide, prednisolone and at least one other immunosupressive agent ( or a lesser period if this therapy cannot be tolerated) 3. age 18-70 exclusion criteria: 1. hbeag or hcv ab positive or known hiv positivity ( hiv testing not necessary for this study) 2. pregnancy, inadequate contraception or lactation 3. malignancy 4. current enrolment in pother clinicla trials -

Keywords: rituximab, anca, vasculitis, lupus,
campath/fludarabine/melphalan transplant conditioning for non-malignant diseases

Conditions: Metabolic Disorders; Hematologic, Immune, or Bone Marrow Disorders; Hemoglobinopathies; Non-malignant Disorders

Summary: the hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. it is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.

the study uses reduced intensity conditioning that is immune suppressive to achieve donor cell engraftment without exposure to radiation or high dose chemotherapy in children with non-malignant disorders. the intent is to minimize early and late regimen related toxicities in the context of a reduced intensity regimen. in addition to maximizing opportunity for donor cell engraftment, the trial seeks to minimize toxicities associated with transplant such as graft versus host disease and employs gvhd prophylaxis that seeks to decrease rates of acute and chronic gvhd in the setting of matched and mismatched donor stem cell transplants from marrow and cord blood sources.

Eligibility criteria:
inclusion criteria: stratum 1: patient must have non-malignant disorder, excluding thalassemia. must be receiving a 8/8 hla-matched bone marrow, related or unrelated stratum 2: patient must have thalassemia receiving 8/8 hla-matched bone marrow or 5-8/8 hla-matched ucb. related or unrelated. stratum 3: patient must have a hemoglobinopathy receiving 7/8 hla-matched bone marrow or 5-8/8 hla-matched ucb. related or unrelated. stratum 4: patient must have a non-malignant disorder (excluding hemoglobinopathy) receiving 7/8 hla-matched bone marrow or 5-8/8 hla-matched ucb. related or unrelated. all strata: * recipient age \< 21 years * lansky/karnofsky \>/= 40 * adequate pulmonary, renal, liver, and other organ function as defined in protocol * negative pregnancy test * adequate total nucleated cell or cd34+ dose of product as defined in protocol * if sickle cell, hemoglobin s \<30% exclusion criteria: * hiv positive * invasive infection * pregnancy/lactating

Keywords: bone marrow transplant transplantation hematopoietic umbilical cord related unrelated reduced non-myeloablative nonmyeloablative non-malignant nonmalignant
a study of pf-07260437 in advanced or metastatic solid tumors

Conditions: Ovarian Neoplasms; Endometrial Neoplasms; Breast Neoplasms

Summary: a study to evaluate the safety, tolerability, pharmacokinetics (pk), pharmacodynamics (pd), and antitumor activity of pf-07260437, a b7-h4 x cd3 bispecific mab, in participants aged ≥18 years of age with advanced or metastatic breast cancer, ovarian cancer or endometrial cancer. adult participants with other advanced or metastatic high b7-h4 expressing tumors may be considered after discussion with and approval from sponsor.


Eligibility criteria:
inclusion criteria: * part 1: histological/cytological diagnosis of selected locally advanced or metastatic breast cancer, endometrial cancer and ovarian cancer * part 2a:in second line or more, participants with histological/cytological diagnosis of locally advanced or metastatic hr+ her2- breast cancer showing high b7-h4 expression * part 2b: in second line or more participants with histological or cytological diagnosis of locally advance or metastatic hr+ her2- breast cancer or triple negative breast cancer (tnbc) with no biomarker pre-selection * part 2c: in second line or more participants with histological diagnosis of locally advance or metastatic triple negative breast cancer with high b7-h4 expression * thyroid function within normal laboratory range; in participants with abnormal thyroid function if free t4 is normal and participant is clinically euthyroid, participants is eligible exclusion criteria: * participants with any active malignancy within 3 years prior to enrollment * participants with advanced/metastatic, symptomatic, visceral spread, that are at risk of life-threatening complications in the short term (including participants with massive uncontrolled effusions \[pleural, pericardial, peritoneal\], pulmonary lymphangitis, and over 50% liver involvement). * history of grade ≥3 immune mediated adverse events (including liver function tests that where considered drug related and cytokine release syndrome) that was considered related to prior immune modulatory therapy (eg, immune checkpoint inhibitors, co stimulatory agents, etc.) and required immunosuppressive therapy within 1 year of treatment.

Keywords: cancer of endometrium cancer of the endometrium carcinoma of endometrium endometrial cancer endometrial carcinoma endometrium cancer neoplasms, endometrial cancer of ovary cancer of the ovary neoplasms, ovarian ovarian cancer ovary cancer ovary neoplasms breast cancer breast carcinoma breast tumors cancer of breast cancer of the breast human mammary carcinoma malignant neoplasm of breast malignant tumor of breast