Kornimate/medical-research-clean huggingface dataset:
relationship between functional health status and ventricular performance after fontan--pediatric heart network

Conditions: Defect, Congenital Heart; Arrhythmia

Summary: the purpose of this cross-sectional study was to determine the interrelationships between health status and measures of cardiac performance in children 6 to 18 years of age with congenital heart disease who have undergone a fontan procedure as surgical treatment for functional single ventricle. the goal was to develop a data set that will permit identification of a clinically relevant endpoint for subsequent trials of medical management of the fontan patient.

background: children born with one functional ventricle and who undergo a fontan procedure, have a higher incidence of late complications than other congenital heart patients. while the fontan procedure results in restoring near-normal systemic oxygen saturation, there are recognized problems and little information about the overall health status, functional status and ventricular performance in these children. design narrative: this cross-sectional observational study included children 6-18 years of age who had undergone a fontan procedure for a congenital cardiac defect. prospective data collection for each patient occured within a 3 month time period and included cardiac mri, echocardiography, serology and exercise testing. historical clinical and surgical data, as well as parent and child self reports of health status, was collected.

Eligibility criteria:
inclusion criteria * age 6 through 18 years at the time of enrollment. * fontan surgery of any type at least 6 months prior to the time of testing. * agreement and ability to have all of the following testing completed: 1. an echocardiogram at the study center, 2. parent health status questionnaire, and 3. blood testing. * planned or ongoing cardiac care at the study center that will allow completion of study testing within 3 months of study enrollment. * informed consent of a parent or guardian, and assent of the study participant if he/she is able to provide it, according to institutional guidelines. exclusion criteria * non-cardiac medical or psychiatric disorder that would prevent successful completion of planned study testing or would invalidate the results of study testing. * ongoing or planned participation in another research protocol that would either prevent successful completion of planned study testing or invalidate the results of study testing. * lack of reading fluency by the primary caregiver in both english and spanish, languages for which the parental report health status questionnaire has been validated. * pregnancy at the time of enrollment or pregnancy planned prior to completion of study testing.
neuroprotective effect of remote ischemic conditioning in ischemic stroke treated with mechanical thrombectomy

Conditions: Stroke, Ischemic

Summary: the benefit of mechanical thrombectomy in the treatment of ischemic stroke has been demonstrated in several multicenter randomized trials. however, it leads to a sudden reperfusion of the brain parenchyma associated to an extension of the infarct volume. evidence has indicated that remote ischemic conditioning (ric) reduces final infarct size in animal stroke models. the main objective of the present study is to determine whether remote ischemic conditioning can limit the final infarct volume after recanalization of the occluded cerebral artery.


Eligibility criteria:
inclusion criteria: * age at least 18 years old, * carotid ischemic stroke related to a full occlusion of the middle cerebral artery (occlusion of middle 1 (m1) and/or proximal middle 2 (m2) identified as candidate for endovascular intervention according to local criteria, * brain magnetic resonance imaging (mri) performed within 6 hours from symptoms onset, * acute stroke mri including at least diffusion weighted imaging (dwi), fluid attenuated inversion recovery (flair), intracranial vessel imaging with magnetic resonance angiography (mra) and perfusion weighted imaging (pwi), * modified rankin score (mrs) score less than or equal to 1 before ischemic stroke, * obtaining a written informed consent of the patient or a next of kin, or emergency inclusion process. non inclusion criteria: * previous ischemic stroke or transient ischemic attack (tia) in the previous 3 months, * contraindications to iodinated contrast agents, * sickle cell disease known (risk of vaso-occlusive crisis), * life expectancy less than 90 days, * pregnant or women of childbearing age who were not using contraception (oral diagnosis), * patient without health coverage, * patient under legal protection. * any contraindication to magnetic resonance imaging (mri) (example cardiac pacemaker), * intracranial bleeding, * intracranial expansive process. exclusion criteria: * recanalization of m1 or proximal m2 segment at the time of thrombectomy

Keywords: ischemic stroke mechanical thrombectomy ischemia/reperfusion remote ischemic conditioning magnetic resonance imaging
mask usage and physical performance during covid-19 pandemic in geriatrics

Conditions: Exercise Capacity; Geriatric; Mask

Summary: in the covid-19 pandemic, the use of masks in daily life has become an important issue. the most important measure taken to prevent contagion is the use of masks. the aim of the study is to determine the effects of surgical masks used in every moment of life on physical performance in elderly individuals.

physical performance measurements were carried out by a physiotherapist using the senior fitness test (sft). participants were informed about the procedure of the test. all participants performed two evaluation sessions by the sft with and without using a surgical mask. the participants were randomly selected to perform the test whether with or without the surgical mask at first. the sessions were held at least 24 hours apart to prevent fatigue.

Eligibility criteria:
inclusion criteria: * geriatrics who had a score of ≥24 in the mini mental test * which evaluates the cognitive levels of individuals over the age of 65 * who were sufficient to perform physical function tests * who had not been diagnosed with covid-19 before exclusion criteria: * participants with severe respiratory disease (tuberculosis, severe copd or bronchiectasis), * uncontrolled cardiac arrhythmia, unstable angina, heart failure, severe kidney disease, neurological disorders that could cause consciousness change * whose disease could not be controlled with medication

Keywords: mask usage geriatrics exercise capacity physical performance senior fitness test
clinical trial to evaluate the efficacy, pharmacokinetics (pk) interactions and safety of dolutegravir plus 2 nucleoside reverse transcriptase inhibitors (nrtis) in hiv-1-infected solid organ transplant patients

Conditions: HIV-1-infection; Solid Organ Transplant

Summary: the aims of this study are to obtain pharmacokinetic data on interactions between dolutegravir (dtg) and immunosuppressant drugs (cyclosporine a, tacrolimus, sirolimus and mycophenolic acid) in solid organ transplant (sot) recipients to provide proof of principle data that dtg plus 2 nucleosides (nucs) is safe and effective in hiv-infected sot recipients.


Eligibility criteria:
inclusion criteria: 1. hiv patients \>18 years old who provide signed and dated informed consent; 2. males and females; 3. sot recipients (heart, liver or kidney); 4. on stable antiretroviral therapy (art) for ≥6 months preceding the screening visit; 5. plasma hiv rna \ 50 between determinations); 6. absence of major reverse transcriptase or integrase gene mutations affecting study drug efficacy by proviral dna sequencing exclusion criteria: 1. hiv patients who have stopped art due to virological failure; 2. hiv patients who require treatment with dtg contraindicated medications; 3. history or presence of an allergy or intolerance to the study drug; 4. active opportunistic infection; 5. neoplasms requiring chemotherapy. 6. pregnancy or breast feeding or planned pregnancy during the study period 7. any other contraindication to study drugs.
senyo health with substance use disorder (sud) in primary care

Conditions: Substance Use Disorders; Substance Abuse

Summary: the purpose of this study is to examine the barriers, facilitators, and optimal processes for implementing a digitally enhanced screening, brief intervention, and referral to treatment (sbirt) model for substance use disorder sud treatment among mayo primary care clinics.


Eligibility criteria:
inclusion criteria: * ability to read, write, and understand english * minimum dast (1+), audit-c score (3+) * access and willingness to use a mobile device for asynchronous (text) and synchronous (video) engagement with care. exclusion criteria: * diagnosed personality pathology as the primary presenting concern based on clinical judgment, severe cognitive impairment (e.g., intellectual disability or dementia), or psychosis * inability to actively participate in and learn from psychotherapeutic interaction based on clinical evaluation and clinical judgment * needing a higher level of mental health care as demonstrated by asam32 assessment. * decline to answer suicidality questions.
omeprazole delayed release (dr) capsules bioequivalence study of dr. reddys under fed condition

Conditions: Healthy

Summary: this study examines the bioequivalence of dr. reddy's omeprazole delayed release capsules under fed condition.

this is a randomized, two-treatment, two-period, two-sequence, single dose, crossover bioequivalence study to compare omeprazole 40 mg delayed release capsules (dr. reddy's laboratories ltd.,) with prilosec® 40 mg (omeprazole delayed release capsules) (manufactured by merck \& co., inc., usa) in 54 healthy, adult, human subjects under fed conditions.

Eligibility criteria:
inclusion criteria: * subjects who provided written informed consent. * subjects who were healthy within 18-45 years of age, weighing at least 50 kg. * body mass index of ≥18 kglm2 and ≤ 25 kg/m2, with body weight not less than 50 kg. * subjects with normal health as determined by medical history and physical examination performed within 15 days prior to the commencement of the study (dosing in period-i). * subjects with normal ecg, chest x-ray (pa view) and vital signs. * availability of subject for the entire study period and willingness to adhere to protocol requirements as evidenced by written informed consent.
evaluation of the risks and benefits of abdominal massage treatment in neonatalogy in premature children

Conditions: Premature Infant

Summary: premature birth creates difficulties for the child in starting his diet and digestion. the immaturity of the major vital functions complicates the abdominal transit. the initial diet, essentially parenteral in the central way, decreases progressively according to the digestive tolerance allowing the increase of the enteral feedings to optimize the growth. to ensure this transition, nurses nurses in neonatology service, through their knowledge and expertise, practice a daily gesture: abdominal massage-care. this prevents or remedies a slowing of transit. the paramedical clinical examination of the child, determines the realization of this care. several studies have proved the benefit of massage on the weight gain of premature babies. these stimulate peristalsis, decrease the duration of intestinal transit and the sensations of discomfort and pain related to it. currently in neonatology, developmental care (nidcap) is an approach to individualized care for the premature to improve its evolution. the fine observation of his behavior allows us to adapt our care and to ensure the respect of his pace. however, the first sensory capacity developed in the fetus, the touch can also be a source of over-stimulation for the premature baby. moreover, the greater the prematurity, the greater the risk of occurrence of digestive complications. can the abdominal care-massage in premature babies be harmful or risk increasing existing symptoms? the abdominal care-massage is neither described nor referenced in the nomenclature of nursing, neither taught nor subject to medical prescription. few publications exist on this subject, no large-scale research has been reported. on the other hand, the perception of our empirical practice seems to show that the abdominal massage-care is an important aid to the smooth transit of the premature newborn. transmitted orally by professionals to newcomers to neonatology, this treatment is carried out in a heterogeneous manner according to professionals. convinced of its effectiveness, carers wonder about their practice: is there an optimal technique without risk for the child? determining the absence of risk and the effectiveness of the abdominal care-massage suggests a wider benefit for the well-being and progress of the premature child until he leaves the hospital. this validated practice could be disseminated on a larger scale in other neonatal departments.


Eligibility criteria:
inclusion criteria: * children born before 37 weeks of amenorrhea hospitalized in the neonatology department exclusion criteria: * children with a malformation or a digestive pathology with or without surgery * medical prescription of non-massage care * children born under the secret

Keywords: premature infant, abdominal massage
areal and linear comparison of gingival recession

Conditions: Gingival Recession

Summary: recent advances in digital technology have led to the emergence of precise methods for measuring gingival recession and tissue thickness. this study aimed to compare digital measurement methods and conventional periodontal probe measurements for the assessment of gingival recession influenced by the gingival phenotype. this study involved 128 gingival recession sites from 28 systemically healthy patients aged 18-45 years. the participants were categorized into two groups on the basis of gingival thickness. the plaque index, gingival index, probing depth, clinical attachment level, gingival recession depth, and gingival recession width, and keratinized gingival thickness and width were measured using a manual periodontal probe and an intraoral optical surface scanner. statistical analysis was performed with nonparametric tests because the data were not normally distributed. p\<0.05 indicated statistical significanct.


Eligibility criteria:
inclusion criteria: the study included systemically healthy subjects aged 18-45 years with systemic disease or systemic disease under control. exclusion criteria: the exclusion criteria were as follows: * patients with a history of radiotherapy, * patients with chemotherapy, * immunosuppressive use, * tobacco use, * smoking, * patients with labially exposed teeth and teeth with prominent root protrusions, * pregnancy and lactation, * patients with uncontrolled diabetes, * patients with postorthodontic extractions, * patients with gingival recession, .patients with gingival enlargement caused by piercing and nail-biting habits.

Keywords: gingiva gingival recession screening
the effect of trunk control on sitting balance and upper extremity functions in patients with subacute stroke

Conditions: Stroke

Summary: the study aims to examine whether trunk control affects sitting balance and upper extremity functions in patients with subacute stroke.

patients who meet the inclusion and exclusion criteria will be informed about the study and the participants who agree to participate in the study will be given the "mini-mental test" and "brunnstrom upper extremity staging" tests, respectively. then, trunk impairment scale, trunk control test, function in sitting test, and "fugl meyer upper extremity test" will be applied respectively. thirty patients with stroke will included in the study. trunk impairment scale and trunk control test will used to assess trunk control assessment. fugl-meyer assessment of the upper extremity will used to assess upper extremity. function in sitting test will used to assess sitting balance. to evaluate between correlation trunk control and upper extremity and sitting balance will used to correlation analysis tests

Eligibility criteria:
inclusion criteria: * being diagnosed with stroke and being in the subacute period (stroke onset time is between 0-6 months), * over 18 years old, * mini-mental test score ≥ 24 points, * able to sit independently in a chair for 10 minutes * to be able to understand and follow simple explanations. exclusion criteria: * having been diagnosed with a brain stem or cerebellar stroke, * having neurological or orthopedic pathology, * having acute low back pain, * having undergone surgery in the last 6 months, * having neglect, aphasia and heminanopsis.

Keywords: upper extremity stroke trunk control sitting balance
the effect of virtual reality based task specific exercises in patients with hand flexor tendon injury

Conditions: Tendon Injury - Hand; Flexor Tendon Rupture

Summary: this study,the investigators aimed to investigate the effects of virtual reality-based task-specific exercises applied in addition to conventional rehabilitation program on functional level and disease-related quality of life in patients who underwent surgical repair due to flexor tendon damage due to traumatic hand injury.


Eligibility criteria:
inclusion criteria: * tendon repair operation due to flexor tendon injury in one hand * admission to the traumatic hand rehabilitation outpatient clinic of ankara city hospital physical medicine and rehabilitation hospital within the first postoperative week and enrolled in an early passive mobilization program * must be in the sixth post operative week exclusion criteria: * under 18 years of age * concomitant extensor tendon injury * having any accompanying orthopedic, neurologic, rheumatologic and vascular problems in the premorbid period * presence of cognitive deficit * presence of visual field deficit * presence of postural instability * presence of epilepsy and/or cyber disease

Keywords: flexor tendon rehabilitation virtual reality task specific exercise
mc rct - bpo vs adapalene

Conditions: Molluscum Contagiosum

Summary: non-blinded randomized controlled trial comparing efficacy of topical benzoyl peroxide 10% (vehicle choice per patient preference: e.g. gel, cream, lotion, wash) to topical adapalene 0.1% gel in the treatment of molluscum contagiosum in children aged 1 year old to 14 years old. * two treatment wings: topical benzoyl peroxide 10% (vehicle choice per patient preference) applied 1-2x daily as tolerated vs adapalene 0.1% gel applied 1-2x daily as tolerated. * primary outcome: complete clearance at 12wks (defined as lack of identifiable papular molluscum contagiosum lesions on physical exam) * secondary outcomes: % change in lesion count at 12wks.

* during the course of their normal workday, ou dermatology faculty and residents will be responsible for identifying and recruiting treatment-naïve patients being seen at the ou dermatology clinic for the diagnosis of molluscum contagiosum. these same faculty and residents will be responsible for approaching these patients regarding participation in the study. chart review will not be a part of this selection process aside from what would naturally be done in the course of the patients' care. the same faculty and residents would be responsible for explaining the risks and benefits of study participation, obtaining written consent for study participation from a parent or guardian, obtaining verbal assent from patients aged 7-14 years old (as well as written assent for those capable of reading/writing), and randomizing patients to respective treatment wings using an online random number generator. * # of mc lesions counted at time of recruitment, re-assessed at single follow up appointment at 12wks * list of enrolled patients kept in excel spreadsheet on encrypted department shared drive. data points added alongside patient names until all data points collected for an individual patient, then identifying information removed and replaced with a study number which will be used to refer to their de-identified data set going forward. * patients/caregivers would be responsible for obtainment and application of respective medications (both medications available over the counter for \< $15) * primary and secondary outcomes will be assessed via chi-square test

Eligibility criteria:
inclusion criteria: * children aged 1 year to 14 years old seen in an ou dermatology resident or faculty clinic and diagnosed with molluscum contagiosum who have not received prior treatment for this condition, and whose parent/guardian(s) desire treatment for this condition. exclusion criteria: * patients who have received prior treatment for molluscum contagiosum. * patients with a history of adverse reaction to any topical retinoid, benzoyl peroxide, cinnamon, or other benzoic derivatives (e.g., salicylic acid, hydroquinone, catechol, vanillin). * pregnant females. * patients with caregivers who do not speak english. * patients with caregivers who are unable to provide consent. * patients who decline to assent for participation.

Keywords: /drug ther
biomarkers in patients with high-risk melanoma receiving high-dose interferon therapy

Conditions: Melanoma (Skin)

Summary: rationale: studying samples of blood from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer and predict how patients will respond to treatment. purpose: this research study is looking at biomarkers in patients with high-risk melanoma receiving high-dose interferon therapy.

objectives: * to screen serum specimens using a high throughput protein profiling platform that tests for the highest number of known biomarkers (detectable by antibodies) that could be predictors of response to interferon treatment, autoimmunity, and disease outcome in patients with high-risk melanoma undergoing high-dose interferon (ifna2b) therapy . * to compare soluble factors across all patients at each time point (baseline and during therapy). * to compare pre-therapy vs post-therapy serum samples from these patients. * to assess the kinetics of soluble factors' appearance, persistence, and disappearance during the 12 months of therapy. * to assess whether the amount of specific soluble factors in the pre-therapy sample is predictive of response independent of therapy. * to correlate statistically significant factors with s100 and autoimmunity in these patients. * to confirm the data obtained with the luminex technology. outline: patients are stratified according to survival (\ 5 years). blood samples collected from patients enrolled in e-1694 are analyzed using high throughput protein profiling by elisa to compare changes in levels of putative biomarkers of interferon alfa-2b, including cytokines and paired receptors, chemokines, cell adhesion molecules, metalloproteinases, angiogenic markers, growth factors, soluble receptors, signal transduction molecules, hormones, and other biomarkers of disease and dysregulated immune processes, at baseline and during therapy.

Eligibility criteria:
disease characteristics: * diagnosis of high-risk melanoma * receiving interferon alfa-2b therapy in arm ii of clinical trial e-1694 patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: stage ii melanoma stage iii melanoma stage iv melanoma