Kornimate/medical-research-clean huggingface dataset:
brief suicide & trauma therapy for suicide risk

Conditions: Suicide; Trauma; Psychotherapy; Major Depressive Disorder

Summary: the investigators have developed an integrated suicide intervention, brief suicide and trauma therapy (bstt). bstt combines brief-skills for safer living (brief-sfsl)-a promising method to enhance coping skills and reduce suicidality-with a trauma therapy component to alleviate the specific impacts of childhood trauma on suicide risk. the aim of this pilot is to test 12-weeks of bstt to alleviate suicide risk among individuals with a history of childhood trauma and current suicidality.

in the last 10 years, despite available treatments, suicide rates have not significantly decreased, and individuals who have experienced any type of childhood maltreatment are at increased odds for suicide attempt. effective suicide prevention requires learning skills to cope with suicidality in addition to addressing the antecedent factors that contribute to suicide risk. in the context of those with childhood trauma and suicidality, addressing antecedent factors may require treatments that target symptoms associated with developmental trauma. thus, the investigators have developed an integrated suicide intervention, brief suicide and trauma therapy (bstt). bstt combines brief-skills for safer living (brief-sfsl)-a promising method to enhance coping skills and reduce suicidality-with a trauma therapy component to alleviate the specific impacts of childhood trauma on suicide risk. the aim of this pilot is to test 12-weeks of bstt to alleviate suicide risk among individuals with a history of childhood trauma and current suicidality.

Eligibility criteria:
inclusion criteria: * beck scale for suicidal ideation \> 10 * presence of childhood trauma defined by a minimum moderate score on any of the childhood trauma questionnaire subscales (emotional abuse, physical, abuse, sexual abuse, emotional neglect, and physical neglect * presence of any psychiatric diagnosis * ability to provide informed consent * not receiving other psychotherapy concurrently * ability to undergo psychotherapy in english exclusion criteria: * the presence of cognitive impairment that would limit consent or understanding of bstt * the presence of active psychosis * unwilling or unable to provide informed consent

Keywords: trauma therapy suicide risk
epstein-barr detection in oral cancer

Conditions: Oral Cancer

Summary: the aim of this study is to analyze oral squamous cell carcinoma and healthy oral mucosa for the possible presence of epstein-barr virus (ebv).

epstein-barr virus has been implicated in a range of malignant neoplasms, including in some studies, in the aetiology of oral squamous cell carcinoma but the influence of ebv in oral cancer remains unclear. this study will examine the prevalence of ebv infection in oral cancer by means of nested polymerase chain reaction.

Eligibility criteria:
inclusion criteria: * patients of oral cancer centre - unesp/araçatuba - sp * with oral squamous cell carcinoma exclusion criteria: * without oral squamous cell carcinoma

Keywords: oral cancer ebv pcr
effects of mediyoga in patients with paroxysmal atrial fibrillation

Conditions: Paroxysmal Atrial Fibrillation

Summary: the purpose of this study is to determinate if mediyoga has effects in quality of life, heart rate variability, blood pressure , heart rate in patients with paroxysmal atrial fibrillation (paf).

this is randomized prospective pilot study. eighty patients from danderyd hospital, stockholm, sweden were randomized to either mediyoga group or control group. the mediyoga group were completing yoga for one hour, once a week for 12 weeks together with usual treatment. the controlgroup had only usual treatment.the usual treatment consists of pharmaceutical, cardio version and ablation. quality of life ( sf-36, eq-5d), blood pressure, heart rate and 24-hours ekokardiografi were measured at baseline and after twelve weeks.a follow up after six months was accomplished with sf-36 and eq-5d, bloodpressure and heart rate.

Eligibility criteria:
inclusion criteria: * diagnosis of paf exclusion criteria: * the exclusions criteria were multiple concurrent medical conditions and/or cognitive dysfunction (in the diagnosis of e.g. mental illness), considered not to be able to carry out yoga owing to ability to move and those who have difficulties to understand the swedish language.

Keywords: paroxysmal atrial fibrillation yoga quality of life blood pressure heart rate heart rate variability
biomarkers of cvd dysfunction in hypertensive disorders of pregnancy

Conditions: Cardiovascular Diseases; Pregnancy

Summary: profound and concomitant cardiovascular hemodynamic changes, necessary to support fetoplacental development and its increasing supply demands, occur during a physiological pregnancy characterized by an increase in cardiac output, heart rate and plasma volume, and fall in vascular resistance and blood pressure. the result of these changes is a volume overload that will lead to a compensatory transient left ventricular eccentric hypertrophy. this, together with the pro-inflammatory state typical of pregnancy, represents the pregnancy as a stress-test for the maternal cardiovascular system. pregnancies complicated by hypertensive disorders of pregnancy (hdp), particularly those with early onset and/or complicated by intrauterine fetal growth restriction (fgr), are characterized by a cardiovascular maladaptation. women who experienced hdp in pregnancy, especially pre-eclampsia (pe), more often develop later in life ischemic heart disease, hypertension and stroke, obesity, dyslipidemia, and end-stage renal disease. regardless its clinical impact, very little knowledge is available on the mechanisms by which pe could lead to cardiovascular disease (cvd), and, especially, to heart failure after pregnancy. preliminary results suggest a cross-talk between pregnancy-induced biomarkers and cardio-vascular system. particularly, cultures of neonatal rat cardiomyocytes and fibroblasts were used to investigate the role of the serum of women with hdp in regulating their proliferation. 5-ethynyl-2'-deoxyuridine (edu) was administered to label dna synthesis in proliferating cells. after 3 days of in vitro culture, edu incorporation was analyzed upon immunofluorescence staining using specific antibodies by high content microscopy. a possible protective effect exerted by the selected sera against apoptosis was evaluated, as well, by caspase activation. moreover, the effect of cardiomyocytes and fibroblasts proliferation and apoptosis on maternal hemodynamic parameters was evaluated using median regression models. these data show that the serum of women with hdp triggers a net increase in the percentage of proliferating cardiomyocytes compared to controls. moreover, there were relationship between cardiomyocytes and fibroblasts proliferation and maternal hemodynamics parameters thus, supporting the hypothesis that the serum of women with hdp may contain factors capable of stimulating cardiac cells in response to the cardiovascular stress-test


Eligibility criteria:
inclusion criteria: cases: 1. pregnant women affected by hdp 2. women ≥18 years old 3. women able to give an informed consent controls 1. uneventful pregnancy of women ≥18 years old 2. women able to give an informed consent exclusion criteria: 1. no informed consent 2. women \<18 years old 3. presence of other maternal pathologies as viral disease, diabetes 4. fetal chromosomal/structural anomalies

Keywords: cardiomyocytes microrna, hypertensive disorders of pregnancy
a mobile text messaging intervention for indoor tanning addiction

Conditions: Indoor Tanning

Summary: the purpose of this study is to test the effects of messages communicating the risks (i.e., health harms, addictiveness) of indoor tanning delivered via mobile text messaging among young adult women ages 18 to 30 years who meet screening criteria for indoor tanning addiction.

this is a two arm randomized controlled trial to test the effects of messages communicating the risks of indoor tanning delivered via mobile text messaging as a strategy for promoting cessation among young adult women who meet screening criteria for indoor tanning addiction. eligible participants are young adult women ages 18 to 30 years who meet screening criteria for indoor tanning addiction and have access to the internet and a personal mobile phone to complete study procedures. participants will complete baseline measures and then be randomized to the study arms. the text messaging intervention exposure in the intervention arm will last for four weeks. the control arm will be given basic indoor tanning education information and will not receive any intervention. follow up assessments capturing study outcomes will be administered at 1 month (i.e., immediately post-intervention) and three months post-intervention.

Eligibility criteria:
inclusion criteria: * female * age between 18 and 30 years * meet self-report criteria for tanning addiction * has access to the internet to complete study procedures * has personal mobile phone to complete study procedures exclusion criteria: * male * age less than 18 or greater than 30 * does not meet self-report criteria for tanning addiction * does not have access to the internet to complete study procedures * does not have a personal mobile phone to complete study procedures

Keywords: indoor tanning skin cancer mobile health text messaging
changing diabetes® world tour

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: this study is conducted in the middle east, northern africa and europe. the aim of this study is to contribute to the design of a simple screening strategy for countries in scope, by exploring the association between risk factors and undiagnosed diabetes in a screening study.


Eligibility criteria:
inclusion criteria: * informed consent obtained exclusion criteria: * subjects with known diabetes (exception: women with a history of gestational diabetes should not be excluded) * pregnant women or women who have given birth within less than a month * subjects suffering from severe illness * subjects with the inability to read and understand the information given (either due to illiteracy or vision problems) and therefore unable to give an informed consent * subjects with mental impairment * subjects treated with systemic cortico-steroids
study of a behavioral intervention for older advanced cancer patients and their caregivers

Conditions: Cancer, Advanced; Cognitive Impairment, Mild

Summary: the purpose of this study is to test the feasibility of a telehealth dyadic life review (dlr), adapted from individual life review therapy, with caregivers of older adults with advanced cancer, including those with mild cognitive impairment (mci). the study will enroll 20 dyads of caregivers and older patients with advanced cancer and 20 dyads of caregivers and patients with advanced cancer and mild cognitive impairment (mci).


Eligibility criteria:
patient inclusion criteria: * age ≥ 65 * able to provide informed consent. all patients will be assessed using the university of california, san diego brief assessment of capacity to consent (ubacc) 56 - a score \>14.5 will define ability to independently provide informed consent. * eligible patients have stage iii or iv cancer of any type * additionally, at least 20 patients will have a will have a high likelihood of mci based on screening score of \<26 on the montreal cognitive assessment (moca) within their erecord chart. * able to read and understand english patient exclusion criteria: * patients scoring \<14.5 on the ubacc * unable to identify caregiver to participate in study caregiver inclusion criteria: * one caregiver for each patient will be eligible and must be chosen by the patient. for the purposes of this study, a caregiver is defined as a valued and trusted person in a patient's life who is supportive in health care matters by providing valuable social support and/or direct assistive care. * caregivers will be selected by the patient when asked if there is a "family member, partner, friend or caregiver with whom you discuss or who can be helpful in health-related matters;" patients who cannot identify such a person ("caregiver") will remain eligible for the study. * age 50 or older * ability to provide consent * proficient in english caregiver exclusion criteria * caregivers unable to understand the consent form due to cognitive, health or sensory impairment will be excluded
guided self-change prevention program for alcohol abuse in adolescents in educational settings

Conditions: Alcohol Abuse or Dependence

Summary: this study corresponds to a pretest-posttest randomized experimental design with two arms. arm 1 includes guided self-change program, and arm 2 a psychoeducational program to promote healthy habits. this study aims to analyze the efficacy of a selective and indicated prevention program based on the guided self-change model (gsc) in adolescent alcohol users between 16-18 years. researchers hypothesize that implementation of gsc therapy will lead to a greater reduction of alcohol drinkers compare with the control condition, and will prevent alcohol abuse after 6 and 12 months.


Eligibility criteria:
inclusion criteria: * 16-18 years old. * having inform consent from parents * report using alcohol at least once a month during the previous last three months exclusion criteria: * participants will be excluded if they refer being diagnosed with a severe mental disorder. * have a severe medical illness that will limit participation * being under treatment for a psychological of psychiatric problem. * meet dsm criteria for drug dependence to illegal drugs.
reoxy therapy in the rehabilitation of chronic low back pain patients with comorbidity

Conditions: Low Back Pain

Summary: the aim of this study is to assess the effect of the respiratory therapy method based on short-term intermittent exposures to hypoxia and hyperoxia (reoxy therapy) on the pain intensity, restoration of the lumbar range of motion, physical capacity, disability, mental and vegetative status in chronic low back pain patients with multiple chronic conditions.

this is a randomized, single-blinded, placebo-controlled trial, with chronic non-specific low back pain with multiple chronic conditions. comorbidity constitutes a serious challenge for rehabilitative medicine - significantly reduces the patients' quality of life and restoration of the working capacity. the objective of the present study will be to evaluate the effectiveness of the combined non-medicinal rehabilitation programe which include a course of reoxy- therapy and conventional therapy back pain treatment. 90 patients will be randomly allocated to three treatment groups: experimental ("hypoxic group" - reoxy therapy + conventional therapy back pain treatment), placebo ("sham hypoxic group"- sham- reoxy therapy + conventional therapy back pain treatment) and control (only conventional therapy back pain treatment). the clinical outcomes will be obtained at the completion of treatment (2 weeks) and at 1 month after randomization. the statistical analysis will follow the intention-to-treat principles and the between-group differences will be calculated by using mixed linear models. the outcomes of interest are pain intensity, lumbar range of motion function, general physical and mental status.

Eligibility criteria:
inclusion criteria: * patient with non-specific chronic low back pain for at least 3 months; * a pain intensity of at least 5 points measured by 0 -10 points pain rating scale; * co-morbidity - ihd and/or chf and/or copd and/or chronic bronchitis) * willing and able to consent, complete all assessment and study procedures; exclusion criteria: * specific types of back pain (metastatic cancer or bone cancer or secondary cancers, vertebral fractures, spinal infection, active inflammatory disease); * low back surgery within past 3 months; * serious cardiovascular, cerebrovascular, neuromuscular and other systemic diseases or other diseases affecting physical activity; * any significant systemic illness or medical condition that could affect safety or compliance with study; * major active or chronic unstable psychiatric illness (e.g. depression, bipolar disorder, obsessive compulsive disorder, schizophrenia) within the previous year; * tumour disease except being successfully treated and off treatment with \>2 years. tumour disease except being successfully treated and off treatment with \>2 years. * use of other investigational agents or interventions one month prior to entry and for the duration of the trial;

Keywords: low back pain chronic lumbar back pain
vascular supply identification, lesion extension and search for tumor similarity at a distance by vtm in breast cancer

Conditions: Breast Cancer Female

Summary: when we talk about early identification, we are talking about an already existing injury, triggering a change in the patient's quality of life and a projection of future costs for the health system. innovative aspect: while screening mammography identifies an existing lesion, vtm could: make an early diagnosis before the formation of a visible or palpable tumor mass; check the metabolic activity in suspicious lesions identified by other diagnostic methods; demarcate tumor range and tumor similarity from a distance in breast cancer. regarding the risk x benefit:there are no medications incorporated, associated or administered by the equipment; there is no ionizing radiation incorporated or delivered by the equipment; there are no contraindications for the use of the equipment by the patient (non-ionizing infrared radiation, without contrast or contact); audience destined to operate the equipment: physician / radiologist with training therefore, the research in question is of great relevance for such a debilitating health problem for the patient and for the health system.

breast cancer control has been one of the priorities on the agenda of the national health policy in brazil. thus, the ministry of health, through the publication "guidelines for the early detection of breast cancer in brazil", recommends the identification of the disease in its early stages through early detection strategies. it is estimated that there will be 66,280 new cases of breast cancer for each year of the three-year period 2020-2022 in brazil and population-based cancer registries (rcbp), hospital cancer registries (rhc) and information on mortality are essential requirements for national and regional programs for cancer control, in addition to guiding the research agenda. according to the national cancer institute (inca), the benefit of screening mammography is in early identification, allowing for less aggressive treatment. vtm is a functional method that demonstrates the metabolic intensity in real time, through images in the colors of the visible spectrum without using ionizing energy or contrast. it expresses metabolic alterations before anatomical transformations. it is a method without radiation, contrast, pain or contact, and can be used without limiting the exposure time.

Eligibility criteria:
inclusion criteria: women ≥18 years old; women with breast cancer before oncological treatment; voluntary signature of the free and informed consent term. exclusion criteria: pregnant or lactating women; patients already included in other clinical trials; patients who are undergoing radiotherapy, chemotherapy or post-cancer surgery treatment; patients who need urgent or emergency care; patients with fever or other illness that affects the integrity of the skin; any clinically significant medical condition or medical history that, in the opinion of the investigator, may discourage participation in the study.
relaypro thoracic stent-graft in subjects with thoracic aortic aneurysms and penetrating atherosclerotic ulcers

Conditions: Aortic Aneurysm, Thoracic; Penetrating Ulcer

Summary: investigate the safety and effectiveness of the relaypro thoracic stent-grafts in subjects with thoracic aortic aneurysms (taa) and penetrating atherosclerotic ulcers (pau) of the descending thoracic aorta.

the objective of this study is to investigate the safety and effectiveness of the relaypro thoracic stent-grafts in subjects with thoracic aortic aneurysms and penetrating atherosclerotic ulcers of the descending thoracic aorta.

Eligibility criteria:
inclusion criteria: * subject must be ≥ 18 years of age * subject has specified disease in his/her descending thoracic aorta. * subject have anatomical compliance for the device specified for both access vessels and treatment area. * subject must be willing to comply with the follow-up evaluation schedule. * subject (or legally authorized representative) agrees an informed consent form prior to treatment. exclusion criteria: * subject has specified disease of the thoracic aorta which is not included in the trial, for example: aortic dissection, intramural hematoma, traumatic injury or transection, aortic false aneurysm, ruptured aneurysm. * subject anatomy with significant stenosis, calcification, thrombus or tortuosity. * subjects with specified compromised circulation. * subjects with specified prior procedures. * subjects with allergy to contrast media or device components. * subjects with disease, for example: suspected connective tissue disorder, specified coagulation disorders, specified coronary artery disease, severe congestive heart failure, stroke and/or myocardial infarction (mi) as specified, specified pulmonary disease, specified renal failure. * subjects that are pregnant or planning to become pregnant during the course of the study.
functional neurological disorders in patients admitted in stroke units

Conditions: Functional Neurological Disorders

Summary: functional neurological disorders are an important subgroup of patients with stroke mimics admitted to stroke unit.their clinical profile and outcome are poorly known. the goal of this study is to describe the cognitive and behavioral profile of stroke mimics patients, without evidence of neurological disease.


Eligibility criteria:
inclusion criteria: * age over 18 years old * patients admitted in stroke unit for a neurological deficit, without evidence of neurovascular or othe neurological disease. * nihss ≥ 1 at time of admission * informed and consent patient to study * health insured exclusion criteria: * patient receiving legal protection * pregnant or breastfeeding woman