Kornimate/medical-research-clean huggingface dataset:
efficacy of adw s-100 ionized water nasal spray in decreasing sars-cov-2 viral load.

Conditions: SARS-CoV-2 Infection

Summary: a nasal spray based on advanced water s-100 ionized water would clean the nasal cavity, reduce the viscosity of the mucus and facilitate its elimination and the decongestion of the nose and the prevention of the seizure of the sars-cov-2 to the epithelial cells of the nasal cavity in fact, a nasal spray based on advanced water s-100 ionized water would modify the electrostatic environment of all interactions ensuring this seizure. the negative ions (oh-) contained in advanced water s-100 compete with the negative ions of the heparan sulfate, which will destabilize this essential bond for the virus to enter the host cell. in addition, positively charged basic amino acids, in the presence of the basic ph of adw s-100, will be neutralized by oh- ions which will prevent the formation of salt and hydrogen bridges mediating the formation of the protein s/ace2 complex. the destabilization of all bonds governing the protein s/ace2 association process will prevent the virus from entering cells and replicating. the aim of this study is to evaluate whether the use of adw s-100 ionized water nasal spray reduces the salivary and nasopharyngeal viral load during an 8-day follow-up of persons recently infected with sars-cov-2, and thus potentially decreases the risk of contamination of the entourage.


Eligibility criteria:
inclusion criteria: 1. men and women ≥ 18 years old 2. informed consent 3. beneficiaries of a social security plan 4. vaccinated or unvaccinated against sars-cov-2: * vaccinated individuals have had a 3rd dose for at least one month, or have been infected with sars-cov-2 and have had 2 doses of vaccine for at least one month * unvaccinated persons are naïve to previous sars cov 2 infection 5. positive nasopharyngeal rt-pcr test for selection with a ct viral load ≤ 23 6. have a phone and internet connection to access the entry application exclusion criteria: 1. the participant is related to any member of the study staff or has a close relationship or conflict of interest with the sponsor. 2. known hypersensitivity or allergy to any component of the test product. 3. contraindication to nasal spray 4. insufficient vaccination: any incomplete vaccination schedule * either a 3rd dose within the last month * or sars-cov-2 infection with less than 2 vaccine doses or with 2 vaccine doses less than 1 month old. 5. any condition, including covid, that is likely to result in hospitalization during study participation. 6. conditions that may result in hospitalization during study participation. 7. known pregnancy or positive urine pregnancy test at d0 by the nurse, or current breastfeeding 8. participation in an antiviral clinical trial or other trial using a medical device for disease prevention covid 19
safety,tolerability and pharmacokinetic study of recombinant human interferon alfa 2b in chronic hepatitis c patients (hm10660a)

Conditions: Chronic Hepatitis C Virus Genotype I

Summary: the purpose of this study is to evaluate the safety and tolerability of multiple ascending doses of hm10660a in subjects with chronic hepatitis c(hcv).

* to evaluate the repeat-dose pharmacokinetics (pk) of hm10660a when given by weekly, biweekly, and monthly subcutaneous (sc) injection. * to evaluate the repeat-dose pharmacodynamics (pd) of hm10660a when given by weekly, biweekly, and monthly sc injection. * to explore the antiviral activity of hm10660a at week 4, week 12, and week 24.

Eligibility criteria:
inclusion criteria: * male or female, aged 18 to 65 years old, inclusive * willing and able to provide written informed consent. * previously untreated hcv infection with hcv rna \> 75,000 iu/ml at screening. * hcv genotype 1a or 1b. * body mass index (bmi) between 18 and 38 kg/m2. * willing and able to comply with the protocol and available to complete the study schedule of assessments. exclusion criteria: * pregnant women or women who may wish to become pregnant during the course of the study. * males and females of reproductive potential who are unwilling to use 2 forms of effective birth control throughout the duration of study treatment and for at least 6 months after the last dose of rbv. one method should include a condom with spermicide for males. males must agree to refrain from sperm donation for at least 6 months after the last dose of rbv. * evidence of infection or co-infection with a non-genotype 1 hcv strain. * co-infection with hepatitis b virus (hbv) or human immunodeficiency virus (hiv). * lactating females
volumetric quantification of epicardial fat using semiautomated high resolution atrial ct segmentation in patients with atrial fibrillation receiving catheter ablation

Conditions: Atrial Fibrillation

Summary: the goal of this prospective observational study is to learn about the influence of epicardial fat on the success of catheter ablation in patients with atrial fibrillation.

a volumetric quantification of epicardial fat is examined by dual source cardiac computet tomography in patients with paroxysmal or persistent atrial fibrillation prior to receiving their first catheter ablation for atrial fibrillation. after ablation the recurrence of arrhythmia is examined after 3 and 6 months respectively.

Eligibility criteria:
inclusion criteria: * patients with planned catheter ablation due to paroxysmal or persistent atrial fibrillation * written informed consent * planned computet tomography exclusion criteria: * history of left atrial catheter ablation * minor patients or patients not capable of giving written informed consent * contraindication for computet tomography with contrast agents (e.g. allergy to contrast agents or relevant renal insufficiency or hyperthyreosis) * patients with congenital heart defects or history of cardial surgery

Keywords: epicardial fal
the application of cardiopulmonary exercise testing in assessment outcome of patients with pulmonary hypertension

Conditions: Pulmonary Hypertension; Chronic Thromboembolic Pulmonary Hypertension; Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder)

Summary: cardiopulmonary exercise test evaluate patients with pulmonary hypertension before and after medical or balloon pulmonary angioplasty treatment

patients diagnosed with pulmonary hypertension, including pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, will be evaluated by cardio pulmonary exercise test before and after medical or balloon pulmonary angioplasty treatment

Eligibility criteria:
inclusion criteria: * pulmonary arterial hypertension;( who1) * chronic thromboembolic pulmonary hypertension; * pulmonary arterial hypertension due to other cause; exclusion criteria: * massive hemoptysis; * unable to accomplish cardiopulmonary exercise testing due to neuromuscular disorders; * recent recurrent syncope; * pulmonary hypertension due to hypoxia; * pulmonary hypertension due to left heart diseases.

Keywords: chronic thromboembolic pulmonary hypertension pulmonary arterial hypertension balloon pulmonary angioplasty cardiopulmonary exercise test
the 6-minute pegboard and ring test in patients with fibromyalgia syndrome

Conditions: Fibromyalgia

Summary: the aim of our study is to investigate the validity and reliability of the 6-minute pegboard and ring test in patients with fibromyalgia syndrome.


Eligibility criteria:
inclusion criteria: * being diagnosed with fibromyalgia syndrome * being aged 18-65 * stable use of medication for at least 3 months or longer * volunteering to participate in the study exclusion criteria: * having a musculoskeletal problem that would prevent being tested * having cardiopulmonary and neurological disease * malignancy * pregnancy
correlation between colposcopist findings and digital cervicography employing gynescope system

Conditions: Cervical Dysplasia

Summary: correlation between colposcopist findings and digital cervicography employing gynescope system

up to 30 women that will be referred for colposcopy examination at the standard indications will also undergo a colposcopy examination of the cervix by a gynescope. the physicain performing the optical test will record the findings in accordance with the international federation for cervical pathology and colposcopy (ifcpc) terminology. categorical variable will be included in every record. at later stage, the images obtained by the cervicography will be evaluated and recorded in accordance with the ifcpc terminology. correlation between the categorical findings in both assesments will be compared. the correlation measure will be performed by kappa test according to the categorial result of both measurements.

Eligibility criteria:
inclusion criteria: - patients reffered for colposcopy exclusion criteria: patient refusion

Keywords: digital cervicography gynescope system
feasibility and effectiveness of an additional resistance and balance training in cardiac rehabilitation of older patients after valve surgery or intervention

Conditions: Frailty Syndrome; Quality of Life; Valve Heart Disease

Summary: the aim of the study is to evaluate the short- and medium-term effectiveness of additional moderate dynamic resistance and balance training to the cr-program of old adults after valve surgery or intervention compared to usual care-cr.


Eligibility criteria:
inclusion criteria: * patients after valve surgery and/or intervention * age 65 years and older * ability to start cr within 4 weeks after surgery, * 6-minute walk distance (6-mwd) ≥100- ≤350 m (1) * patient's agreement to participate in the study. exclusion criteria: * diseases in the musculoskeletal system or other organs complicating physical activity and exercise training; * exercise-limiting comorbidities (primarily orthopedic and neurological conditions that would exclude individuals from participating in cr according to study protocol), including chronic heart failure new york heart association class iv, hemoglobin less than 9 g/dl, wound healing disturbance, cognitive or linguistic deficits.

Keywords: cardiac rehabilitation exercise training resistance training balance training physical capacity valve surgery valve intervention functional capacity
efficacy, safety and tolerability of everolimus in combination with reduced exposure cyclosporine or tacrolimus in paediatric liver transplant recipients.

Conditions: Renal Function; Liver Transplant

Summary: this study was designed to assess the evolution of renal function and to collect efficacy, safety, and tolerability data of everolimus in co-exposure with reduced cni in paediatric liver transplant recipients.

study is completed (was active and ongoing but no longer recruiting since december 2014). the study data monitoring committee meeting communicated to novartis the following safety findings in the study population: high rate of premature discontinuation of study medication, high rate of post-transplant lymphoproliferative disease and high rate of related serious infections leading to hospitalization. in light of the safety findings, novartis followed the dmc recommendation to discontinue the study medication in this age group and to stop enrolling new patients in this study (regardless of age).

Eligibility criteria:
key inclusion criteria: signed informed consent from both parents or legal guardian(s) prior to patient participation in the study. paediatric liver transplant recipients aged greater than or equal to 1 month and younger than 18 years of age. paediatric recipients at the earliest 1 month and latest 6 month after liver transplantation. key exclusion criteria: patients with hepato-biliary malignancies and/or patients transplanted due to fulminant hepatitis /acute liver failure. presence of thrombosis of any major hepatic arteries, major/reconstructed hepatic veins, portal vein or inferior vena cava at any time prior to the start of study drug. patients with serum creatinine value \>2 times age-related uln at baseline or who received renal replacement therapy within one week prior to the start of study drug and patients with a confirmed spot urine protein/creatinine ratio indicating a urinary protein excretion \>500 mg/m2/24 hrs, at baseline. patients with clinically significant systemic infection and/or in a critical care setting requiring life support measures such as mechanical ventilation, dialysis, or vasopressor agents. patients with a known hypersensitivity to the drugs used on study or their class, or to any of the excipients. pregnant or nursing (lactating) female patients, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive βhcg laboratory test (\>9 miu/ml) at baseline. female patients of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they agree for abstinence from sexual activity.

Keywords: paediatric liver transplantation everolimus reduced calcineurin inhibitor cyclosporine, tacrolimus renal function composite efficacy endpoint (treated biopsy proven acute rejection death, graft loss) liver transplant
genetic biomarkers associated with child language development in taiwan

Conditions: Child Language

Summary: a study of the relation between genetic biomarkers and child language development in taiwan.

the interaction between gene and environment (g×e) can be a very complicated process that influences child development. as a pilot study of child development biomarkers, this study investigates genes related to child language development and language disorder.

Eligibility criteria:
inclusion criteria of healthy child: * age 2-18 y/o * agree to sign informed consent exclusion criteria of healthy child: * central nervous system disease * neuromuscular disorders * congenital abnormality * genetic disease * dysesthesia * hearing impairment inclusion criteria of child with language disorder: * patients with language disorder * age 2-18 y/o * agree to sign informed consent exclusion criteria of child with language disorder: * hearing impairment inclusion criteria of adult: * his or her child participated in this study, and gene abnormality was found.

Keywords: language development gene whole-exome sequencing body function and body structure quality of life
cohort primary hyperparathyroidism

Conditions: Primary Hyperparathyroidism

Summary: cohpt is a prospective, monocentric, observational cohort including all patients diagnosed with primary hyperparathyroidism in nantes university hospital, aiming to study the outcomes associated with parathyroidectomy. clinical and biochemical evaluation is performed at the inclusion, and 6, 12, 36 and 60 months. a biocollection is collected. the main hypotheses are that parathyroidectomy could improve cardiovascular, renal, bone, and cardiovascular outcomes along with quality of life.

primaty hyperparathyroidism is the third most frequent endocrine disorder, which only curative treatment is the parathyroidectomy (approximately 8000/year). however, evidences suggest that the mildest forms of phpt could be safely monitored with simple surveillance. however, to define surgical indications is challenging because data regarding the impach of surgery on several outcomes (namely cardiovascular, bone, renal or quality of life) are controversial. cohpt is a prospective, monocentric, observational cohort including all consecutive patients diagnosed with sporadic primary hyperparathyroidism in nantes university hospital aiming to study the outcomes associated with parathyroidectomy. patients are followed even if surgery is not performed. a systematic clinical and biochemical evaluation is performed at the inclusion, and 6, 12, 36 and 60 months. these informations include demographic and general medical data, pre-operative imaging exams, post-operative outcomes, histopathological analysis, evaluation of the impact of primary hyperparathyroidism and its surgery on target organs (bone, kidney, cardiovascular) and quality of life. fasting blood samples are also collected to constitute a biocollection, in order to measure biomarkers related to the bone remodeling and the cardiovascular risk. the objectives are: * to know the long-term consequences of the primary hyperparathyroidism treatment or observation. * to better define the surgical indications * to better understand the mechanisms of the cardiovascular impairment by using the biocollection * to study the medico-economics consequences of the surgical management versus simple surveillance

Eligibility criteria:
inclusion criteria: • age \> 18 exclusion criteria: * age \< 18 * pregnancy / lactation * adults underguardianship * secondary/tertiary hyperparathyroidism * multiple endocrine neoplasia

Keywords: primary hyperparathyroidism parathyroidectomy
mind-body skills groups for behavioral and emotional problems in war-traumatized male adolescents in gaza

Conditions: Problem Behavior; Aggression; Posttraumatic Stress Disorder

Summary: the purpose of this study is to determine whether war-traumatize male adolescents with behavioral and emotional problems who participate in mind-body skills groups will have improvement in behavioral and emotional problems, aggression, and posttraumatic stress disorder (ptsd) symptoms, compared to a wait list control group.

mind-body skills incorporate meditation, guided imagery, breathing techniques, autogenic training, biofeedback, genograms, and self-expression through words, drawings, and movement in a small group setting. these groups have been used in war-traumatize populations in kosovo, gaza and the united states. this study will be investigating the effect of the mind-body skills groups on boys with behavioral and emotional problem at a high school in gaza to determine if there is improvement in behavioral and emotional problems, aggression, and posttraumatic stress disorder. the results will be compared to a control high school with boys who will not be attending mind-body skills groups and who have experienced similar levels of trauma and also have behavioral and emotional problems. the mind-body skills groups will be held for 2 hours once a week for 10 weeks and then once a month for 10 months. measures will be taken at baseline, after the 10 week mind-body skills group program and again at 10 month follow-up.

Eligibility criteria:
inclusion criteria: * criteria for eligibility for the study will include having a baseline self-reported score of 18 points or higher on the strengths and difficulties questionnaire which indicates high to very high levels of emotional and behavioral problems exclusion criteria: * none

Keywords: problem behavior aggression posttraumatic stress disorder adolescents
additive benefits of kaltenborn sustained stretch joint mobilization with resistance exercise training in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: to determine the supplementary effects of kaltenborn sustained stretch mobilization when combined with resistance training in the management of knee osteoarthritis.


Eligibility criteria:
inclusion criteria: grade i-iii knee oa both male and female nee osteoarthritis for at least 3 months knee pain no more than 8/10 exclusion criteria: malignancy any additional inflammatory disorders infection knee trauma lower limb fracture lumbar radiculopathy or myelopathy knee surgery intra-articular steroid therapy in the last 2 months total knee replacement (tkr). total hip replacement (thr). any neurological disorder any cardio-pulmonary complications rheumatoid arthritis septic arthritis recent history of trauma osteoporosis or osteomyelitis grade iv osteoarthritis -
tini 2: total therapy for infants with acute lymphoblastic leukemia ii

Conditions: Lymphoblastic Leukemia

Summary: the purpose of this study is to improve upon the tini study treatment. the study will test the ability of a type of immunotherapy called blinatumomab to clear persistent leukemia. blinatumomab targets cd19 which is located on the leukemia cells outer membrane.


Eligibility criteria:
inclusion criteria: * patient is ≤ 365 days of age at the time of diagnosis. * patient has newly diagnosed cd19 positive acute lymphoblastic leukemia (all) or acute undifferentiated leukemia. subjects with bilineage or biphenotypic acute leukemia are eligible provided they express cd19. patients with cd19 positive mature b-cell all who carry a kmt2a rearrangement are eligible. * limited prior therapy, including hydroxyurea for 72 hours or less, systemic glucocorticoids for one week or less, cytarabine for 72 hours or less, one dose of vincristine, and one dose of intrathecal chemotherapy. * written informed consent following institutional review board, nci, fda, and ohrp guidelines. exclusion criteria: * patients with prior therapy, other than therapy specified in inclusion criteria. * patients with mature b-cell all that do not have a kmt2a rearrangement or patients with acute myelogenous (aml) or t-cell all. * patients with down syndrome. * inability or unwillingness of legal guardian/representative to give written informed consent
the effect of pre-operative transversus abdominis plane (tap) block in the post operative opioid consumption in morbid obese patients undergoing laparoscopic gastric bypass surgery: a prospective,randomized, blinded study

Conditions: Pain; Obesity; Surgery

Summary: the use of preoperative tap block in laparoscopic bariatric surgery can improve the postoperative pain and quality of recovery in patients undergoing these procedures.


Eligibility criteria:
inclusion criteria: * age: 18-65 years * bmi \>35 kg/m2 * surgery: laparoscopic gastric bypass surgery * asa status: i, ii and iii * fluent in english exclusion criteria: * history of allergy to local anesthetics * chronic opioid use * pregnant patients * patients who remained intubated after surgery drop-out criteria: patient or surgeon request complications related to the procedure or conversion to open route patient requiring mechanical ventilation after surgery

Keywords: tap block pain obesity surgery laparoscopic banding