Kornimate/medical-research-clean huggingface dataset:
evaluation the effect of muscle functional electrical stimulation in the upper limb tremor invalidating

Conditions: Upper Limb Tremor Invalidating

Summary: the main objective of this study is to identify the superficial muscle groups involved in gene-related tremor and assess the reduction in the intensity of the tremor after transient electrical stimulation.


Eligibility criteria:
inclusion criteria: * subject with disabling tremor of upper limb * subject with essential tremor action and / or lesion exclusion criteria: * subject with drug tremor * subject presenting an exaggerated physiological tremor * subject with isolated resting tremor
a study to evaluate safety of upadacitinib in combination with topical corticosteroids in adolescent and adult participants with moderate to severe atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the objective of this study is to assess the safety of upadacitinib combined with topical corticosteroids (tcs) in adolescent and adult participants in japan with moderate to severe atopic dermatitis (ad) who are candidates for systemic therapy.


Eligibility criteria:
inclusion criteria: * active moderate to severe atopic dermatitis defined by eczema area and severity index (easi), investigator's global assessment (iga), body surface area (bsa), and pruritus. * candidate for systemic therapy or have recently required systemic therapy for atopic dermatitis. * able to tolerate topical corticosteroids for atopic dermatitis lesions. exclusion criteria: * prior exposure to any janus kinase (jak) inhibitor. * unable or unwilling to discontinue current atopic dermatitis (ad) treatments prior to the study. * requirement of prohibited medications during the study. * female participant who is pregnant, breastfeeding, or considering pregnancy during the study.

Keywords: upadacitinib topical corticosteroids atopic dermatitis
a study to evaluate the efficacy and safety of intravenous ceftaroline versus intravenous ceftriaxone in the treatment of adult hospitalised patients with community-acquired bacterial pneumonia in asia

Conditions: Community-Acquired Bacterial Pneumonia; Lung Infection of Individual Not Recently Hospitalized

Summary: this purpose of this study is to evaluate the efficacy and safety of intravenous ceftaroline versus intravenous ceftriaxone in the treatment of adult hospitalised patients with community-acquired bacterial pneumonia in asia.


Eligibility criteria:
inclusion criteria: * males and females 18 or more years of age * lung infection of individual not recently hospitalized meeting the following criteria: radiographically-confirmed pneumonia (new or progressive infection site of the lungs) consistent with bacterial pneumonia), and acute illness (≤ 7 days duration) with at least three of the following clinical signs or symptoms consistent with lung infection: new or increased cough, purulent sputum or change in sputum character, auscultatory findings consistent with pneumonia, difficulty in breathing, short breath, or decreased partial pressure of oxygen in blood, fever greater than 38ºc oral or body temperature lower than that required for normal body function(\< 35ºc), white blood cell count greater than or less than the normal, greater than 15% immature neutrophils (bands) irrespective of white blood cell count, and moderate lung infection * the subject must require initial hospitalization, or treatment in an emergency room or urgent care setting, by the standard of care * the subject's infection would require initial treatment with intravenous antimicrobials * female subjects of child-bearing potential, and those who are fewer than 2 years post-menopausal, must agree to, and comply with, using highly effective methods of birth control while participating in this study exclusion criteria: * lung infection of individual not recently hospitalized suitable for outpatient therapy with an oral antimicrobial agent * confirmed or suspected respiratory tract infections attributable to sources other than bacteria from the individuals not recently hospitalized(e.g., ventilator-associated pneumonia, hospital-acquired pneumonia, visible/gross aspiration pneumonia, suspected viral, fungal, or mycobacterial infection of the lung) * non-infectious causes of lung lesion (e.g., pulmonary embolism, chemical pneumonitis from aspiration, hypersensitivity pneumonia, congestive heart failure) * accumulation of pus in the pleural cavity * microbiologically-documented infection with a pathogen known to be resistant to ceftriaxone, or epidemiological or clinical context suggesting high likelihood of a ceftriaxone-resistant "typical" bacterial pathogen.

Keywords: community-acquired bacterial pneumonia
ultrasound guided transversus abdominis plane(tap) block in intensive care unit

Conditions: Colon Neoplasm; Rectum Neoplasm; Perforated Colon; Perforated Bowel

Summary: the transversus abdominis block (tap) block is known to be an effective means of reducing patient pain after abdominal surgery. in the meantime, the general tap block has been studied in patients who were in the recovery room and the ward after surgery. the purpose of this study was to determine the effect of pain reduction and opioid saving effects in patients with tap block in icu settings.

this study is a prospective study in a single institute of seoul national university bundang hospital and is assigned to the test group and the control group by random assignment. in both groups, pca (patient controlled analgesia) was used as a post-operative pain control modality. in the intervention group, a 0.25% bupivacaine was used for transverse nerve block , and normal saline was used for placebo(control) group the tap block will be performed within 1 hour after entering the intensive care unit (icu) in double blinded state

Eligibility criteria:
inclusion criteria: * adults over 20 years of age * patients who entered the intensive care unit for monitoring and recovery after colonic resection through laparotomy * patients who voluntarily sign a written informed consent and know they have the right to withdraw their consent at any time. exclusion criteria: * patients who are unconscious and require sedation below the richmond agitation sedation scale (-2) patients who need continuous renal replacement therapy, cardiopulmonary bypass patients with a history of allergic reactions to local anesthetics patients resistant to narcotic analgesics (users of existing long-term narcotic analgesics) patients who can not use self-analgesic treatment patients who underwent surgery for organs other than abdomen and pelvis patients with severe blood clotting disorders with a prothrombin time international normalized ratio of 2.0 or greater and platelet less than 50,000
investigating inter-individual variability in glycemic and insulin responses

Conditions: Hyperglycemia; Insulin Sensitivity

Summary: this study aims to test the following hypothesis in healthy lean young men: * there are differences in glycemic response (gr) and insulin response (ir) between chinese, malay and asian-indian * there are differences in gi values to the same food between ethnic groups * there are ethnic differences postprandial gr and ir for high vs low gi foods * mastication, salivary amylase activity, gastric emptying rate and gut microbiota composition influences inter-individual glycemic and insulinemic variability * ethnic differences in mastication, salivary amylase activity, gastric emptying rate and gut microbiota composition determines the inter-ethnic glycemic and insulinemic variability

there is extensive evidence that numerous biological digestive factors varies between individuals and influence postprandial glycemic response (gr) and insulin response (ir), which are well established risk factors that precipitate the development of type 2 diabetes mellitus (t2dm). however, no study to date has measured and compared physiological parameters such as mastication, salivary amylase activity, gastric emptying rates and gut microbiota in a multi-ethnic asian population, with varying prevalence of obesity and t2dm. the aim of this study is to investigate ethnic differences in gr and ir as well as the gi values of foods. additionally, we aim to examine how physiological digestive factors contribute to inter-ethnic and inter-individual variability in gr and ir. the study outcomes can potentially explain, in part, the varying susceptibility to obesity, t2dm and dm control between chinese, malays and asian-indians in singapore, as reflected by the differences in prevalence of obesity, t2dm and dm control among the three local ethnic groups.

Eligibility criteria:
inclusion criteria: * be willing and able to comply with study procedures and given written informed consent * chinese/malay/indian males, aged 21-40 years old * body mass index (bmi) between 18.5 - 24.9 kg/m2 * fasting blood glucose between 4 - 6 mmol/l * sedentary adults, with \<1 episode of exercise per week * not have a history of food allergies or food intolerances * be a non-smoker * drinks less than 3 units of alcohol per day * not taking antibiotics for the past 3 weeks exclusion criteria: * subjects with known chronic diseases, including diabetes, untreated hypertension, renal impairment, gastrointestinal problems, and other significant medical conditions * bmi \ 25 kg/m2 * fasting blood glucose ≥7.0mmol/l * alcohol consumption \>3 drinks / day * use of medications known to affect glucose metabolism * recent changes in weight of \>5% over the past 3 months * significant changes in diet over the past 3 months * history of eating disorders or irregular eating habits * taking antibiotics medications over the past 3 weeks

Keywords: ethnic differences inter-individual variability glycemic response insulin response mastication salivary alpha-amylase gastric emptying metagenome
bipolar study in adults at least 18 years of age

Conditions: Bipolar Disorder

Summary: bipolar study of tolerability, clinical response and patient satisfaction


Eligibility criteria:
inclusion criteria: * diagnosis of bipolar i disorder. * must be on a stable regimen of psychiatric medication for at least 2 months prior to study. * if female, must not be pregnant, or must be incapable of conceiving or be taking steps to prevent conception. exclusion criteria: * patients with a clinically significant psychiatric or physiologic comorbidity including significant substance abuse, depression or mania which is of an unstable of progressive nature that could interfere in participation of this study. * presence of untreated thyroid disease. * patient is actively suicidal or homicidal. * patient has history of severe hepatic or renal insufficiency. * patient is currently participating in another clinical trial.

Keywords: bipolar disorder lamotrigine
primary acl reconstruction in patient over 40 years: allograft versus autograft

Conditions: ACL; ACL Injury

Summary: the aim of this study is to investigate the differences in graft failure between patients that underwent acl reconstruction using allograft tendons and patients that underwent acl reconstruction using autograft tendons in patients older than 40 y.o. and after at least 2 years of follow-up. the hypothesis of the study is that there will be a difference in graft failure and patient reported functional outcomes between allograft and autograft acl reconstruction.


Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * male and female patients of fertile age can be recruited * patients aged 40 years old and above, and 2 years minimum of follow-up * patients that underwent primary acl reconstruction with allograft an autograft tendons exclusion criteria: * multiligamentous lesion * meniscal tear leading to subtotal or total meniscectomy or meniscal graft * indication for major cartilage restoration or resurfacing * ipsilateral knee fractures * history of ligament injury * concomitant extracapsular procedures * ipsilateral or contralateral knee surgeries
neurophysiological effects of dry needling in patients with neck pain

Conditions: Myofascial Pain Syndrome

Summary: the present study aims to evaluate the differences that may be experienced in pain and cervical disability, before, during and just after the intervention of the deep dry needling in the upper trapezius muscle in active, passive myofascial trigger points (mtp) or non-mtp in patients with neck pain, assessing, in turn, the neurophysiological effects on the autonomic nervous system. hypothesis: deep dry needling of active myofascial trigger points produces a greater decrease of pain and cervical disability index and increase of pressure pain threshold; than the deep dry needling of myofascial trigger points latent or out of myofascial trigger points in patients with chronic neck pain. objective: to determine the efficacy of deep dry needling applied on active myofascial triggers (mtp) vs. latent mtp versus mtp, on pain reduction and cervical disability, in patients with chronic neck pain attributable to myofascial pain syndrome.


Eligibility criteria:
inclusion criteria: * non-specific neck pain, unilateral or bilateral. * neck pain ≥ 3 months of duration. * presence of active and latent mtp in the upper, left, right or bilateral trapezius muscle, in relation to the patient's neck pain. * clinical criteria recommended to identify active and latent mtp: 1. tensile band palpable. 2. exquisite local pain at the pressure of a taut band node. 3. recognition by the patient of their usual pain when pressing on the sensitive nodule (to identify an active mtp). 4. painful limitation of range of mobility to complete stretching. it is considered positive when 3 of the 4 clinical criteria are found. exclusion criteria: * unsurpassed fear of needles. * coagulation disorders. * specific alterations of the cervical region in the clinical history. * infiltration of corticosteroids or local anesthetics during a year before the study. * surgical intervention of the cervical region or previous shoulder. * skin lesions in the area, as well as infection or inflammation. * taking analgesic, anti-inflammatory or anticoagulant medication the week before the study. * treatment of mtp or deep dry needling in the neck region in the 6 months prior to the intervention. * cognitive deficit in the medical history.

Keywords: dry needling myofascial pain syndrome neurophysiological effects autonomic nervous system
immunotep for patients with medullary thyroid carcinoma.

Conditions: Medullary Thyroid Carcinoma

Summary: the aim of this study is to optimize pretargeting parameters using pharmacokinetic and imaging data for immuno-pet using anti-cea x anti-hsg tf2 bsmab and 150 mbq of 68ga-imp-288 peptide in mtc patients with abnormal ct serum level after initial complete surgery and at least one abnormal lesion

variation of tf2 molar dose, imp-288 molar dose and pretargeting interval will be performed in 4 to 5 cohorts of 3 patients, receiving 30 to 120 nmol of tf2 and 1.5 to 6 nmol of peptides 1 to 3 days apart. blood samples will be obtained after tf2 and 68ga-imp-288 injections. a last cohort (cohorte number 5 or 6) with optimal conditions will be proposed. whole-body pet images will be recorded 60 and 120 minutes after 68ga-imp-288 injection to assess semi-quantitatively tumor targeting and tumor/background ratio. moreover, the targeting sensitivity of the tf2-pretargeted 68ga-imp-288 will be compared to standard methods of tumor. some patient will have a second immuno-tep for their follow up in the first examen was the most sensible.

Eligibility criteria:
inclusion criteria: * histological diagnosis of cmt * calcitonin\> 150 pg / ml * complete treatment of the primary tumor * at least one detectable lesion more than 10 mm on conventional imaging: bone lesions can be taken into account if they extend outside of the bone and the party extra bone is measurable. * age ≥ 18 years * negative pregnancy test for women of childbearing age in the previous 2 days immuno-pet. women of childbearing potential should use effective contraception take continuously for 3 months. * kps ≥ 70 or ecog 0-1 and life expectancy of at least 6 months * absence of serious illness or co-morbidity assessed risk * creatinine ≤ 2.5 normal * absence of cancer treatment within 6 weeks prior to the immuno-pet * no history of cancer within 5 years, except skin cancer other than melanoma or carcinoma in situ of the cervix * lack of anti-antibodies in patients who have previously received antibodies and hypersensitivity to antibody or protein * informed consent signed * social insurance exclusion criteria: * pregnancy or breastfeeding * serious illness or co-morbidity assessed risk * history of cancer within 5 years, except skin cancer other than melanoma or carcinoma in situ of the cervix * presence of anti-antibodies in patients who have previously received antibodies * known hypersensitivity to antibody or protein * need to establish a cancer treatment within 3 months of immuno-pet (before stock evaluation 3 months) * inability intellectual sign consent * patient protected by law

Keywords: thyroid, endocrine tumour nuclear medicine, molecular imaging immunotep
pain, fatigue and sleep quality of e-athletes

Conditions: E-Athletes

Summary: e-sports, which attract great attention in the media and social networks, brings health problems and some risks, depending on the attractiveness of games and the time spent in the digital world. when the investigators examine the literature, although different studies are showing that e-athletes experience pain and sleep problems, no study examines the factors related to pain and sleep quality together. therefore, our study was planned to examine the factors associated with pain, fatigue, and sleep quality in e-athletes.


Eligibility criteria:
inclusion criteria: * be over 18 years old * take part in professional matches for at least one year * have an e-sports license * volunteer exclusion criteria: * be retired, * having any systemic, orthopedic or neurological disease

Keywords: e-athletes pain fatigue sleep quality
immunogenicity and safety study of a booster vaccination with a recombinant h5n1 influenza ha vaccine in primed adults

Conditions: Influenza

Summary: the study is designed to assess the immunogenicity and safety of one booster vaccination with 45 μg of a recombinant h5n1 influenza (a/indonesia/05/2005) ha vaccine in healthy young adults, previously primed with a two-vaccination of 3 different doses of a recombinant h5n1 influenza (a/vietnam/1203/2004) ha vaccine in a priming study (jpip501-01a, nct00980447).


Eligibility criteria:
inclusion criteria: * subjects who completed a priming study (jpip501-01a, nct00980447) * male and female healthy adults * written informed consent obtained from the subject before study entry exclusion criteria: * history of h5n1 influenza or vaccination of other h5n1 influenza vaccines * clinically diagnosed cardiovascular, hematological, psychological, neurological, hepatic, renal, pulmonary (including asthma), endocrinological or gastrointestinal disorder * confirmed immune deficiency conditions, or diagnosed autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus * severe allergic reactions or anaphylaxis to foods or drugs (including vaccines) * treatment with disallowed drugs including other study drugs * pregnant or nursing (lactating) women other protocol-defined inclusion/exclusion criteria may apply

Keywords: avian influenza, h5n1, pandemic, recombinant ha vaccine
single incision versus three port laparoscopic cholecystectomy

Conditions: Laparoscopic Cholecystectomy

Summary: laparoscopic cholecystectomy (lc) became the standard treatment for symptomatic gallbladder disease. single incision laparoscopic surgery (sils) was developed with the aim of reducing the invasiveness of conventional laparoscopy. the aim of this study was to compare the clinical outcome of single-incision laparoscopic cholecystectomy (silc) with three port laparoscopic cholecystectomy (tplc).

from february 2014 to september 2016, patients with symptomatic cholecystolithiasis at two university hospitals (sohag university and qena university hospitals) were enrolled in this study. the number of patients needed was calculated. considering a power of 80% and reliability of 0.05, the investigator found that 76 patients should be present in each group. the study was started with 275 patients for the possible loss of patients and data during the study. eligible patients (206 patients) were randomly divided equally into two groups (group 1; silc, group 2; tplc) according to a computer-generated random numbers. of 103 patients allocated to intervention in each group, 14 patients were excluded from silc group and 5 patients from tplc group, and the remaining 89 \& 98 patients in silc \& tplc group respectively were included in the study. routine investigations and surgical fitness were done in all cases. patient demographics, bmi, asa score, indication for cholecystectomy, operative time, estimated blood loss, success and conversion rate, postoperative pain score, postoperative analgesia requirement, morbidity and mortality, length of hospital stay, and patient cosmetic satisfaction were recorded. a fixed analgesia protocol with intravenous non-narcotic (ketorolac tromethamine 30 mg) was used twice daily. an opioid (pethidine hcl 50 mg) was added when the pain cannot be tolerable. postoperative pain was evaluated according to a visual analogue scale (vas) from 0 (no pain) to 10 (maximum pain) on the postoperative sixth hour (vas-6h) and on postoperative day one (vas-24h). patient cosmetic satisfaction was recorded at one month follow-up visit on a scale from 1 (worst) to 10 (best). patients were shown the same photograph of a right sub-costal (kocher) incision which was rated 0 on the cosmetic scale and were asked to rate their satisfaction based on the previous observation. the study protocol was approved by the local ethical committee. also, a written informed consent was obtained from all patients' prior recruitment to study.

Eligibility criteria:
inclusion criteria: 1. preoperative diagnosis of symptomatic gallstones 2. age from 20 to 60 years, 3. american society of anesthesiologists (asa) grade i, ii or iii, 4. agreement to complete the study requirement. exclusion criteria: 1. patients with contraindication to laparoscopy, 2. suspected mirizzi syndrome, 3. choledocholithiasis, 4. hepatobiliary malignancy, 5. previous upper abdominal surgery, 6. previous mesh repair of an umbilical hernia, 7. long-term anticoagulant treatment, 8. pregnant female 9. stone more than 2 cm in preoperative ultrasonography.