lidocaine and neuroma pain related modalities

Conditions: Neuropathic Pain

Summary: background subanesthetics concentrations of lidocaine are able to produce a differential block of the ectopic discharges, but not propagation of impulses, suppressing differentially the associated neuropathic pain symptoms. the aim of this study was to investigate the differences between the analgesic effects of lidocaine 0.5% and a control group of lidocaine 0.1% on several neuroma related pain modalities. methods sixteen patients with neuropathic pain due to painful neuromas caused by nerve injury participated in this randomized, double-blind experiment. the patterns of sensory changes were compared before and after injection of 1 ml lidocaine 0.5% and 0.1% close to the neuroma, the sessions being 1-2 weeks apart. spontaneous and evoked pains were assessed using a visual analogue scale (vas), quantitative and qualitative sensory testing.

patients were recruited by using a postal follow up questionnaire . the number of enrolled subjects in this study- 16 patients, study design * the patients visited the pain clinic twice. * the same investigator (am) performed all study procedure assessments. * neuroma was localized by tinel's sign 14 and when possible (7 patients out of 16), the localization of a neuroma was verified by ultrasound. administration of study drug the patients were randomized by a computer generated random list to receive either 1ml lidocaine 0.5% (a) or 1 ml 0.1% (b-control) injected perineuromally. pain assessments duration of the present pain condition was recorded. the patients were asked to rate the mean, maximum, minimum pain intensity of their spontaneous and evoked pain in the week prior to both visits. the pain score was measured from baseline until 60 min after injection. assessments of pain were done post injection at 15 s, 30 s, 1 min, and at 5-min intervals for the first 30-min post injection and then every 10-min to 1 hr post injection. the assessments of pain were performed between the limbs in the following order: spontaneous pain, then assessment of dynamic mechanical allodynia and then pinprick hyperalgesia. spontaneous pain evaluation of sensory function was performed in the affected limb using bedside examination according to efns (european federation of neurological societies)guidelines: light touch, pinprick sense, warmth (40°) and cold (25°) temperature stimuli were tested.

Eligibility criteria:
inclusion criteria: * 18 years or older, * with a history of persistent spontaneous and/or evoked pain (by e.g. touch, movement), * who scored an average daily pain intensity of at least 4 on a 0-10 point numerical pain scale (nrs) interfering with daily activities and who had pain at least 3 months duration. * they all had neuromas after upper extremity surgery or other trauma affecting the radial, ulnar, median or digital nerves and were eligible to participate in the study after giving written informed consent. exclusion criteria: * patients with other conditions that might confound assessment of pain attributed to posttraumatic upper limb pain or * any condition/disease that could interfere with the study measurements, such as drug abuse, diabetes, vascular disease, polyneuropathy or psychiatric diseases were excluded.