Kornimate/medical-research-clean huggingface dataset:
breast localization: rfid tags vs wire localization

Conditions: Breast Neoplasm Female

Summary: the rfid trial focuses on breast localization in patients with non-palpable breast cancers. it aims to demonstrate the improvement in patient comfort when using the radio frequency identification (rfid) tag and localizer™ device compared to the gold standard device.

it is an observational, prospective, single-center, 2-arm (rfid group vs. standard gold), non-randomized and category 3 comparative study. the rfid trial focuses on breast localization in patients with non-palpable breast cancers. these patients will benefit from a mastology consultation: consent will then be acquired. the rfid tag or the gold standard localization will be put in place during this consultation (one day before surgery). patients will fill in their questionnaire in two steps: * during the installation of the device (rfid tag or wire localization) to evaluate the patient's pain, * then at the 1-month post-operative consultation to assess pain in the interval until surgery radiologists and surgeons will fill out the questionnaire dedicated to them after each procedure.

Eligibility criteria:
inclusion criteria: * patients 18 years of age or older, * requiring conservative surgical management for a breast lesion -infra-clinical (fibroadenomas, papillomas, atypical lesions, neoplasia), whose histology will have been proven beforehand by anatomopathology. * patients referred to mastology for preoperative identification by the surgeons * able to give informed consent to participate in the research. * affiliation to a social security regime exclusion criteria: * multiple breast lesions * patients with breast neoplasia during pregnancy. * person deprived of liberty or under guardianship or incapable of giving consent * refusal to participate

Keywords: non palpable breast cancer rfid tags observational study surgery
digital game addiction and cyberbullying in adolescents

Conditions: Level of Digital Game Addiction; Level of Cyberbullying

Summary: with the widespread use of technology and internet, digital game addiction and cyberbullying behaviors have increased among adolescents. effective interventions are needed to prevent these behaviors. the aim of the study is to determine the effect of health education supported by motivational interviewing on digital game addiction and cyberbullying behaviors in adolescents. the research will be conducted with a randomized controlled trial design. the intervention group will receive six sessions of motivational interviewing-supported health education. within the scope of the intervention, the first two sessions will be health education and the last four sessions will be motivational interviewing. it is planned that each session will be 35 minutes and the sessions will be implemented one week apart.


Eligibility criteria:
inclusion criteria: * continuing 9th grade education * volunteering to participate in the research * being given permission by their families to participate in the study exclusion criteria: * having problems understanding and speaking turkish * visual-hearing impairment * having a neuropsychiatric disease

Keywords: digital game addiction cyberbullying adolescent motivational interview health education
epidemiological study in subjects with vulvovaginal candidiases

Conditions: Vulvovaginal Candidiases

Summary: epidemiological study about the clinical and microbiological progress in subjects under treatment for a severe vulvovaginal candidiases episody


Eligibility criteria:
inclusion criteria: * sexually active women between 18 and 50 years of age at time of screening * with diagnosis and symptomatology of vvc exclusion criteria: * pregnant women * diabetes mellitus * women witihin three months after a delivery or misbirth * women with vaginal or genital infection symptomatology other than candidiases that needs antibiotic treatment * vaginal probiotics use within last three months * undiagnosed abnormal genital hemorrhage

Keywords: candidiases vaginal infections
lumbopelvic manipulation effects on fatigue in chronic low back pain patients

Conditions: Chronic Low Back Pain

Summary: the aim of the study is determine the effects of lumbopelvic manipulation on fatigue, pain and disability in chronic low back pain patients. in this randomised clinical trial, lumbopelvic manipulation group was compared with conventional therapy group. tools used in the study are numeric pain rating scale ,oswestry low back pain index and rating of fatigue scale.

low back pain is an extremely common problem which causes morbidity in adults. it is more likely to occur in individuals around the age 20 to 60, this is partly due to the changes that occurs with aging. it can be acute (less than 12 weeks) or chronic (more than 12 weeks). there are many causes of low back pain one of the most common is the lumber disc herniation. some of the most serious causes of low back pain include (infection, malignancy, vertebral fracture, cauda equina syndrome and inflammatory disorders such as axial spondyloarthritis). mostly low backpain can be a result of injury such as muscle strain or sprains due to sudden movements or poor body mechanics while lifting heavy loads. pain in low back can be the result of infection effecting the bony lumber spine, ligaments around the spine, the spinal cord, nerves and muscles of the spine, internal organs and skin around the spine. treatment for low back pain falls into three broad categories, multidisciplinary therapy is based on intensive exercises that improves physical function and has modest effects on pain physiotherapy treatment of low back pain includes laser, massage, multidisciplinary rehabilitation and spinal manipulation. spinal manipulation is a high velocity thrust to a joint beyond its restricted range of movement. spinal manipulation to lumber spine is a common intervention administered for patients with low back pain. there is limited use of the technique in our society especially finding its effects on fatigue in chronic low back pain.

Eligibility criteria:
inclusion criteria: females patients having fatigue along with chronic low back pain low back pain for more than three months age 20-60 exclusion criteria: * patients with conditions other than chronic low back pain having radiculopathy history of serious underlying pathology such as nerve root compromise, structural deformities, genetic spinal disorders and previous spinal surgery.
back2livewell: community based prevention of back pain flare-ups

Conditions: Low Back Pain, Recurrent; Low Back Pain

Summary: the primary objective of this study is to compare the effectiveness and cost-effectiveness of an individualized group based exercise and education program supported in the community to a control group of usual care in preventing back pain flare-ups and to mitigate the negative consequences of subsequent episodes if they occur.

secondary objectives are to: • to compare the effectiveness of the two interventions in preventing an activity-limiting lbp flare up at 12 and 24 months. secondary objectives are to: * to compare the effectiveness of the interventions in mitigating the negative consequences of lbp. * to evaluate the cost-effectiveness of the interventions in preventing activity-limiting lbp flare-up. * to identify subgroups of individuals that may best respond to each one of the two interventions. exploratory objectives include: * evaluate the fluctuating nature of back pain using a smart phone application to collect pain measures once a week for 1 year (trajectories will also be evaluated to compare between group effects) * assess adherence to physical activity using activity monitors. * evaluate the relationship between activity levels and flare-ups as a method for understanding pain triggers and impact of activity pacing.

Eligibility criteria:
inclusion criteria: participants will be included if they meet the following criteria * have been discharged \<3 months from physiotherapy, chiropractic or osteopathic care following a course of treatment for lbp (pain in the area between the 12th rib and buttock crease) * have non-specific lbp which is pain not attributed to a specific diagnosis such as sciatica, ankylosing spondylitis, vertebral fracture, etc. * non-specific lbp sometimes called mechanical lbp accounts for \~85% of lbp diagnosis. * between 18 and 80 years of age exclusion criteria: participants will be excluded if they meet the following criteria: * ongoing high pain intensity, defined as pain intensity of 6 or more on a 0-10 point scale. the cut off of 6/10 is used in the literature to dichotomise low/moderate to high pain intensity. * co-morbidity preventing participation in physical activity evaluated using the physical activity readiness questionnaire (par-q) from the american college of sports medicine guidelines * inadequate english to complete outcome measures * currently participating in an exercise program similar to the one we will evaluate. * history of spine surgery

Keywords: prevention exercise randomized controlled trial physical activity
effect of osteopathic lymphatic treatment on plasma volume, protein concentration and albumin concentration.

Conditions: Healthy Volunteers

Summary: the goal of this project is to see how much an osteopathic lymphatic treatment (olt) causes an increase in plasma volume, total plasma protein concentration, and albumin concentration. this is an important step in understanding the effects of olt, specifically its effects on fluid in the body. the primary role of the lymph system is the return of fluid and proteins lost from the blood vessels. despite this, no research has been done to see what effects an olt has on fluid and protein levels in the blood.


Eligibility criteria:
inclusion criteria: * normal, healthy volunteers * males * age 20 to 40 years exclusion criteria: * history of cardiovascular, kidney, or liver disease. * cannot have taken medication or drugs or have been ill at the time of the study or for two weeks prior.

Keywords: osteopathic lymphatic treatment olt normal
hair counts from vertical and horizontal sections of scalp biopsy specimens in thai population with alopecia

Conditions: Alopecia

Summary: hair disorders, expecialy scarring alopecia were diagnosed by scalp biopsy specimens in horizontal and vertical sections.(1-4) data on hair density in thais are lacking, although in asians have more fewer hairs than whites.(5-7)howevery, previous study from east asian just had only one study and the data was more differently from west asian and whites. then this study was performed to evaluate hair density in thais, and compared to previous study.


Eligibility criteria:
inclusion criteria: * thai * age \>= 18 years * diagnosis alopecia and on list for hair transplantation in siriraj hospital exclusion criteria: * alopecia areata or positive hair pulling test * underlying disease : dm, chronic renal failure, chronic liver disease

Keywords: scalp biopsy hair count vertical section horizontal section thais
assessment of quality of life and satisfaction with medical care of pediatric type 1 diabetes mellitus patients

Conditions: Type 1 Diabetes Mellitus

Summary: the purpose of this study is to evaluate the change score for the pedsql short form diabetes and core modules and the patient assessment of chronic illness care measured at baseline (before changing care delivery models) and 12 months after transitioning to the team model of care delivery.

pediatric type 1 diabetes mellitus patients and their parents will complete the forms before and 12 months after the diabetes clinic at children's mercy hospital in kansas city, mo transitions to a team model of care delivery.

Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus six years of age and older who are receiving care in the diabetic clinic at children's mercy hospital exclusion criteria: * t1 diabetes mellitus patients not receiving care in the diabetes clinic at children's mercy hospital or not meeting the age requirements

Keywords: type 1 diabetes mellitus quality of life satisfaction of medical care delivery
a study of safety, pk, & pd of isis 416858 administered subcutaneously to patients with end-stage renal disease on hemodialysis

Conditions: End-stage Renal Disease (ESRD)

Summary: evaluation of safety, tolerability, pk and pd of isis 416858 in patients with end-stage renal disease (esrd) receiving chronic hemodialysis.

evaluation of safety, pk and pd of isis 416858 in patients with end-stage renal disease (esrd) receiving chronic hemodialysis. the overall objectives are to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of isis 416858 in esrd patients on hemodialysis.

Eligibility criteria:
inclusion criteria: * end stage renal disease maintained on outpatient hemodialysis at a healthcare center for \> 3 months from screening with hemodialysis using heparin (unfractionated heparin or low-molecular weight heparin) 3 times per week for a minimum of 3 hours per dialysis session and plan to continue this throughout the study. exclusion criteria: * documented thrombotic event (acute coronary syndrome, stroke or transient ischemic attack, venous thromboembolic event) in the past 3 months. * active bleeding within the past 3 months from screening or documented bleeding diathesis (history of bleeding disorder) or screening values of: * platelet count \< 150,000 cells/mm3 * inr \> 1.4 * aptt \> upper limit of normal (uln) * abnormal liver function at screening: * alt or ast \> 2 x uln * total bilirubin \> uln * concomitant medication restrictions: concomitant use of anticoagulant/antiplatelet agents (e.g., dabigatran, rivaroxaban, clopidogrel) that may affect coagulation (except low dose aspirin (≤ 100 mg/day) during treatment and post-treatment evaluation periods is not allowed. * uncontrolled hypertension as judged by the investigator. patients with a pre- or post-dialysis blood pressure (bp) that is \> 160 mmhg on at least 3 of last 5 dialysis treatments. * planned major surgery in the next 6 months (e.g. renal transplant surgery)
shared interactive book reading in preschool children with neurodevelopmental disorders: effects on language development and reading habits

Conditions: Neurodevelopmental Disorders; Autism Spectrum Disorder; Intellectual Disabilities; Language Disorders in Children

Summary: the goal of this observational retrospective study is to explore the effects of a parent-based book reading intervention on children with neurodevelopmental disorders. the project consisted of interactive lessons for parents and shared reading experiences. it took place between may 2021 and june 2022 in rome and at the time children were receiving neuropsychomotor and speech therapy sessions based on the developmental profile. the investigators'primary goal is to investigate lexical quotients of children who participated in the project to explore whether it had an impact on their language development. the secondary goal is to assess shared reading habits. for both outcome measures, researchers will compare the group who partecipated in the study with a cohort of children with the same characteristics who also attended fondazione don carlo gnocchi for rehabilitation purposes. patients and their family will not be asked for any further engagement because all data will be taken from medical records.


Eligibility criteria:
inclusion criteria for the study group: * age between 1 and 6 years old * having attended at least 2 out of 5 parent training meetings and 2 out of 9 reading aloud sessions * at least one caregiver with a good command of the italian language, * having given written consent to participate exclusion criteria for both groups: * cerebral palsy or severe sensory disorder (deafness, blindness) * limited command of the italian language * lack of informed consent

Keywords: shared reading early literacy neurodevelopmental disorder autism intellectual disability vocabulary shared reading habits language disorders shared interactive book reading
phase ii study of brivanib (bms-582664) to treat multiple tumor types

Conditions: Advanced Non-small Cell Lung Cancer; Transitional Cell Carcinoma; Soft Tissue Sarcoma; Gastric/Esophageal Adenocarcinoma; Pancreatic Cancer Including Ampulla of Vater

Summary: the purpose of this study is to determine if gastric/esophageal, lung, pancreatic, bladder and sarcoma patients show benefit from brivanib treatment. patients who clearly do, stay on treatment. those in which it is unclear will be randomized to continue or withdraw treatment to determine whether that benefit is related to brivanib


Eligibility criteria:
for additional information, please contact the bms oncology clinical trial information service at 855-216-0126 or email mycancerstudyconnect@emergingmed.com. please visit www.bmsstudyconnect.com for more information on clinical trial participation. inclusion criteria: * life expectancy at least 3 months * diagnosis of a solid tumor which is unresectable in which no approved effective therapy exists or for subjects who are intolerable to such therapy. the initial enrollment will focus on non-small cell lung, gastric/esophageal adenocarcinoma, soft tissue sarcoma, transitional cell carcinoma, and pancreatic cancer including ampulla of vater tumors * adequate tumor sample * adequate recovery (baseline or grade 1) from recent therapy. at least 1 week must have elapsed from the time of a minor surgery, and at least 8 weeks for major surgery or radiation therapy exclusion criteria: * subjects with known brain metastasis. * subjects with signs or symptoms suggestive of brain metastasis are not eligible unless brain metastases are ruled out by ct or mri medical history and concurrent diseases: * history of thrombo-embolic disease within the last six months requiring therapeutic anticoagulation * subjects with history of poor wound healing or non healing ulcers * uncontrolled or significant cardiovascular disease allergies and adverse drug reactions: * history of allergy to brivanib its drug class, or related compounds prohibited treatments and/or therapies: * exposure to any investigational drug within 4 weeks of enrollment * other concurrent chemotherapy, hormonal therapy, immunotherapy regimens or radiotherapy, standard or investigational. subjects may continue to receive hormone replacement therapy * prior exposure to brivanib
clinical characteristics and mechanism research of inhibitors of janus kinase in the idiopathic inflammatory myopathies

Conditions: Idiopathic Inflammatory Myopathies

Summary: this study aims to explore the clinical characteristics and mechanism of inhibitors of janus kinase in the treatment of idiopathic inflammatory myopathies

the investigators designed a single center, open-label, prospective study. adults with active idiopathic inflammatory myopathies will be enrolled, meeting the bohan \& peter dermatomyositis/polymyositis(dm/pm) or rheumatology(acr) \& european allance of associations for rheumatology(eular)(2017) diagnostic criteria. inhibitors of janus kinase including tofacitinib 5 mg once a day or twice a day and baricitinib 2mg once a day or 4mg once a day was administered for 6 months to explore its efficacy and safety, which could help to evaluate inhibitors of janus kinase's clinical characteristics and mechanism. patients would be evaluated the improvement of clinical and laboratory indexes. changes of symptoms, immune cell subsets and cytokines were monitored. symptoms were evaluated by visual analogue scale (vas) of patient global and physician global, manual muscle testing(mmt-8), the health assessment questionnaire(haq), creatine kinase, myositis disease activity assessment tool(mdaat).

Eligibility criteria:
inclusion criteria: * adults between 18 years and 75 years of age. * adults with active idiopathic inflammatory myopathies will be enrolled, meeting the bohan \& peter dm/pm or american college of rheumatology(acr) \& european allance of associations for rheumatology(eular)(2017) diagnostic criteria. * written informed consent should be obtained from each study subject. * concomitant immunosuppressive agents or glucocorticoids were allowed, but subjects should have been on these therapies at least 4 weeks and on a stable dose for ≥4 weeks(glucocorticoid doses are lower than \<0.5mg/kg/d). * consent to use effective contraception during the study (women of childbearing age). exclusion criteria: any subject meeting either of the following criteria should be excluded: * laboratory abnormality: hb\<8 g/dl or platelet\<60\*10\^9/l, or combined with severe hepatic, renal and cardiac insufficiency; * myositis in overlap with another systemic autoimmune rheumatic disorder, cancer-associated myositis, inclusion body myositis or any other non-immune mediated myopathy. * biologics such as rituximab are not allowed in the 3-month before enrollment. * patients with malignancy within 3 years of screening. * patients with hypersensitivity to study drug. * active infections(including but not limited to hepatitis, hiv). * uncontrolled mental or emotional disorders.
the effects of exopulse mollii suit on low back pain

Conditions: Low Back Pain

Summary: low back pain is a common musculoskeletal problem. it is the main cause of activity limitation and work absence and carries a huge medical burden and economic cost. low back pain is considered "chronic" when it persists for more than 3 months. chronic low back pain affects daily activities and constitutes a psychological burden, which could lead to anxiety and/or depression. prevention of low back pain is recognized as a pivotal challenge in high-risk populations to help tackle high healthcare costs related to therapy and rehabilitation. current pharmacological drugs, namely anti-inflammatory and narcotics medications, have limited efficacy and numerous side effects. in addition, most available treatment options only address single, targeted causes; however, given the complexity of low back pain, a multi-modal interdisciplinary approach is highly needed. transcutaneous electrical nerve stimulation (tens) is a safe alternative to current treatments. many studies have shown its efficacy and benefit in reducing pain. however, it only targets a limited number of muscles. for this reason, transcutaneous stimulation using the exopulse mollii suit might help reduce pain and related outcomes in this context since it simultaneously targets several muscle groups.


Eligibility criteria:
inclusion criteria: * patients aged between 18 and 75 years, with a definite diagnosis of low back pain for at least 3 months, with absence of any surgical indication. * stable pharmacological treatment over the last three months * residual back pain post-spinal surgery with no new surgical indication * patients should be french speakers, able to understand verbal instructions, and affiliated to the national health insurance nhi. exclusion criteria: * patient with vas \< 4 * presence of any surgical indication (i.e,. isthmic spondylolisthesis, herniated disc, spinal canal stenosis, vertebral fracture, degenerative spondylolisthesis, scoliosis) * failed back surgery syndrome (fbss) * presence of spinal infection * presence of obstetrical or gynecological cause of the low back pain (ovarian torsion, ovarian cyst, endometriosis, menses) * retroperitoneal tumors - spinal tumors - being included in another research protocol during the study period * inability to undergo medical monitoring for the study purposes due to geographical or social reasons * having a cardiac stimulator, a ventriculoperitoneal shunt, an intrathecal baclofen pump, or other contraindications to using exopulse mollii suit * being pregnant * having a change in their pharmacological therapy in the last three months. * suffering from other somatic or neuropsychiatric diagnoses (e.g., arrhythmias, uncontrolled epilepsy, diseases causing osteoarticular and muscular pain) * having a body mass index above 35 kg/m2 * in case of the introduction of a medical device other than exopulse mollii suit during the study period * patients under juridical protection (" mesure de protection judiciaire : tutelle, curatelle, sauvegarde de justice ") * prisoners

Keywords: exopulse mollii suit and low back pain