Kornimate/medical-research-clean huggingface dataset:
beyond ageing project: a study for the prevention of depression

Conditions: Depression; Depressive Disorder

Summary: the purpose of this study is to determine whether folate and vitamin b12, physical activity and mental health literacy can prevent depression, and folate and vitamin b12 and physical activity can prevent cognitive impairment in older people. also the study aims to assess the benefits for older people in improving their knowledge about mental health in relation to depression.

while preventive efforts for depression have tended to focus on adolescent and young adult populations, other stages of the lifespan also provide opportunities for prevention. with older people, there are certain risk and aetiological factors, which become more prominent and require preventive action at that point in the lifespan. the aim of this study is to determine the efficacy of various interventions in preventing depression and cognitive decline among older people who are at high risk of developing major depression because they are currently suffering from depressive symptoms. the study has three interventions; i) folate and vitamin b12, ii) physical activity; and iii) mental health literacy. participants will be randomly allocated to receive each combination of the interventions (folate and vitamin b12 or placebo, physical activity intervention programme or physical activity no-intervention control, mental health literacy intervention \[containing written modules with information about depression that is relevant to older people\] or mental health literacy no-intervention control group). participants will receive these interventions over a two-year period with regular assessments across that time period.

Eligibility criteria:
inclusion criteria: * aged 65-74 years with some depressive symptoms, assessed using the kessler 10 psychological distress scale \[k10\] (andrews \& slade, 2001) exclusion criteria: any of the following: * those currently taking medication or receiving psychological treatment for depression * a report of a medical diagnosis of bipolar disorder/mania * history of epilepsy * diagnosed with cancer and/or on antifolate therapy * have a diagnosis of dementia or alzheimer's disease * are currently taking vitamin supplements containing folate, b2, b6 or b12 at a dose exceeding 25% of the recommended daily intake. * medical contradictions to exercise (e.g., significant orthopaedic problems or cardiovascular disease that would prevent regular aerobic exercise) * ongoing participation in regular aerobic exercise.

Keywords: depression cognition depressive disorder mental health literacy older adults randomzed controlled trial
association of protein intake with sarcopenia among institutionalized elderly

Conditions: Sarcopenia; Protein Deficiency

Summary: this study has purpose to investigated the association of protein intake with sarcopenia in the institutionalized elderly at south tangerang

data were collected using interview with subjects or with care giver to know the basic characteristic of subjects. anthropometric measurements were done body weight in kilograms was measured using seca scale. body height in meters was predicted by knee height measurement using knee height caliper. body mass index (bmi) was calculated as weight per height square. fat free mass was examined using bioelectrical impedance analyzer tanita type sc-330. independency was assessed using barthel index. protein intake was measured using 2x24 hour food recall and analyzed using a computer program nutrisurvey 2007, data were compare to recommended dietary allowances established for indonesian 2018. handgrip muscle strength was examined using jamar handgrip dynamometer. physical performance was measured using short physical performance battery test. sarcopenia was diagnosed using asian working group on sarcopenia. all data collected were analyzed using statistical package for the social science (spss) version 20 for windows. nominal data were described using frequency, n (%). normality of data was tested using kolmogorov-smirnov test with normal distribution (p\>0.05) described using mean and sd while not normal distribution (p\<0.05) described using median and range minimum-maximum. the investigators used independent t-test analysis to investigate the association.

Eligibility criteria:
inclusion criteria: 1. inclusion criteria were being male or female 2. aged more than 60 years old 3. signed inform consent form and literate with help from companion exclusion criteria: 1. subjects with history of cancer 2. history of upper and lower extremities weakness 3. history of chronic heart failure disease 4. chronic obstructive pulmonary disease

Keywords: protein intake sarcopenia institutionalized elderly
observational study of males with creatine transporter deficiency

Conditions: Creatine Deficiency, X-linked

Summary: the objectives of this study are to illustrate the clinical, neuro/electrophysiologic, biochemical, and developmental status and progression of patients with creatine transporter deficiency (ctd) and to evaluate the utility of performance-based and other measures in the ctd population.

this is an observational study designed to determine an appropriate clinical assessment battery for males with ctd, and to evaluate magnetic resonance spectroscopy (mrs) along with other potential biomarkers. it is designed to explore developmental domains of interest and to examine the feasibility and utility of various neuropsychological assessments to measure domains of interest, and to identify possible endpoints for interventional studies. study will also explore genotype-phenotype correlations. clinical adverse events will be monitored throughout the study. this study was previously posted by lumos pharma, which has been transferred to ultragenyx in june 2019.

Eligibility criteria:
inclusion criteria: 1. subject has genomic confirmation of a pathologic mutation in the slc6a8 gene. 2. subject is able to complete study-related procedures. 3. subjects' parents/guardians/caregivers must provide written consent (informed consent) to study-related procedures, and if appropriate, the subject will provide an assent. exclusion criteria: 1. subject has had status epilepticus within 3 months of screening. 2. subject is unable to comply with the study procedures or with a clinical disease or laboratory abnormality that in the opinion of the investigator would potentially increase the risk of participation.

Keywords: creatine transporter developmental delay intellectual disability x-linked language seizure observational brain spectroscopy
the effect of household air pollution on lung function growth in infants with pneumonia in sub-saharan africa

Conditions: Pneumonia; Pollution; Exposure; Lung Function Decreased; Chronic Respiratory Disease; Pediatric Respiratory Diseases; Lungs; Developmental Disorder

Summary: this study will evaluate the feasibility and acceptability of a household-based clean air intervention

a clean air intervention will be implemented in each household, including hepa- based air filtration, solar lighting, and education. the air filtration system will be cycled monthly, with active filtration alternating with no filtration for one month on/one month off. to determine the effect of the clean air intervention within the household, pm2.5 concentration during each cycle and lung function will be measured among household members.

Eligibility criteria:
inclusion criteria: * age \< 12 months • first episode of who-defined severe pneumonia22: cough or difficulty breathing with * oxygen saturation \< 90% or central cyanosis, * severe respiratory distress, or * signs of pneumonia with a general danger sign * be willing to commit to entire 2 years of follow up visits. * (controls) matched to each case on age (+/-1 month), sex, and community exclusion criteria: * craniofacial, cardiac or other major malformation * neuromuscular condition that affects respiration * outside smart discharges project catchment area * prior hospitalizations or known episodes of respiratory illness or episodes of pneumonia before index admission,
carbapenem-resistant pseudomonas aeruginosa: the sampan study.

Conditions: Pseudomonas Aeruginosa; Colonization, Asymptomatic; Nosocomial Infection

Summary: pseudomonas aeruginosa causes severe infections in hospitalized patients. the worldwide emergence of carbapenem-resistant p. aeruginosa (cr-pa) makes infections by these pathogens almost untreatable. the world health organization now ranks cr-pa highest in the list of 'urgent threats'. information for action to prevent further emergence has to come from insight into sources and transmission routes through smart surveillance. at present, a smart surveillance strategy is not available for cr-pa. the aim of this project is to develop a globally-applicable smart surveillance strategy to guide action against the spread of cr-pa. since p. aeruginosa prefers moist niches, we will focus on the human-water interface. first, highly-sensitive methods to detect cr-pa in specific environmental and human niches will be developed. subsequently, cr-pa will be collected in three study sites with increasing prevalences of cr-pa, increasingly warmer climates, and different water situations: rotterdam (the netherlands), rome (italy), jakarta (indonesia). cr-pa will be searched for in a variety of niches in the environment outside and inside the hospital, and in healthy humans and hospitalized patients. whole genome sequencing will be performed to compare the cr-pa from different sources and identify transmission routes. our project will provide insight into the relative contribution of the different potential reservoirs of cr-pa to its spread in different settings which will be used for the development of a globally-applicable surveillance strategy for cr-pa to guide preventive actions.


Eligibility criteria:
inclusion criteria healthy individuals: * all healthy individuals living in a "high-risk area" in rotterdam, rome or jakarta. exclusion criteria healthy individuals: * no signed consent sheet inclusion criteria patients: * must be aged 18 years or older; * should be capable of providing answers to the questions in the questionnaire by himself/herself; * should have a minimum expected length of stay of at least 24 hours; * inclusion only once during the sampling year. exclusion criteria patients: * cystic fibrosis patients * no signed consent sheet.
safety and efficacy of salsalate to treat endothelial dysfunction in hiv-infected adults

Conditions: HIV; Endothelial Dysfunction; Inflammation; Insulin Resistance

Summary: this is a phase ii, open label, randomized-controlled pilot study designed to study both the efficacy and safety of salsalate in decreasing endothelial cell dysfunction, systemic inflammation, and insulin resistance in hiv-infected adults. the investigators hypothesis is that salsalate will reduce inflammation and therefore endothelial cell activation and insulin resistance. the sample size will be 40, with an equal number of people being randomized to one of two groups. the first arm will be randomized to salsalate therapy. the second arm will act as a control group. the study duration will be 13 weeks.


Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. hiv-infected 3. evidence of durable virologic suppression, i.e., must have hiv-1 rna \< 400 copies/ml at study entry and for at least 12 weeks prior to entry 4. on a stable antiretroviral (arv) regimen, i.e., on the same arv for at least 12 weeks prior to study entry 5. no intention to stop or modify arv regimen during the study period exclusion criteria: 1. current pregnancy or breast feeding, or women of child bearing age who refuse or are unable to use appropriate methods for contraception during the study period 2. any of the following conditions: diabetes (2 fasting glucose levels \> 126 mg/dl or confirmed random glucose level \> 200), creatinine clearance \< 50, aspirin-sensitive asthma, copd, history of bleeding gastric or duodenal ulcer, hepatic dysfunction, active hepatitis b or c, and any active infectious or inflammatory condition 3. need for regular use of any of the following medications: salsalate, aspirin, non-steroidal antiinflammatories (nsaids), corticosteroids, warfarin or other anticoagulation therapy, phenytoin, valproic acid, carbonic anhydrase inhibitors, lithium, probenecid or sulfinpyrazone 4. consumption of alcohol on a daily basis 5. active use of illicit drugs 6. unable to attend follow-up appointments 7. allergy to any salicylic acid-containing medication or salsalate 8. ast or alt \> 2 upper limit of normal (uln) within 6 months prior to study entry

Keywords: hiv endothelial dysfunction inflammation insulin resistance
effect of intravenous vitamin c on intrapartum maternal fever after epidural labor analgesia

Conditions: Obstetric Labor Complications; Fever

Summary: this study aims to explore the effect of intravenous vitamin c infusion on intrapartum fever after epidural labor analgesia, to reduce the impact of intrapartum fever on maternal and infant, improve maternal and infant outcomes, and provide a reference for clinical preventive medication.

parturients who request pain relief would receive epidural labor analgesia after the obstetrician and anesthesiologist jointly evaluated and approved. the epidural catheter was inserted at the intervertebral space of either l2-3 or l3-4. 5 ml 1.5% chloroprocaine (with 1:200,000 epinephrine) as a test was delivered to parturients via the catheter. then parturients would be observed for 5 min whether there were adverse reactions and then were given an initial dose of 10 ml ropivacaine 0.08% with sufentanil 0.3 µg/ml. after that, a patient-controlled epidural analgesia (pcea) pump (240ml 0.08% ropivacaine with sufentanil 0.3 µg/ml) would be attached to the catheter. the pump would be set to administer an 8 ml bolus every 20 minutes and a 2 ml patient-controlled bolus with the same interval. subsequently, trained nursing staff would take charge of the parturients and inform the obstetrician. the basic condition of parturients was monitored during the whole process. after that, parturients in each group will be administered vitamin c intravenously except the group for placebo-controlled.

Eligibility criteria:
inclusion criteria: * single-fetus, head position, and full-term vaginal delivery receiving epidural labor analgesia. exclusion criteria: * have a fever before epidural analgesia, acute infection on admission, incomplete baseline data, fatal fetal malformations or comorbidities, duration from admission to delivery of more than 72 hours or less than 3 hours, or an american society of anesthesiologists (asa) classification of ≥ ⅲ.

Keywords: intrapartum maternal fever epidural analgesia inflammation vitamin c
anatomopathological evaluation of a new ultrasound-guided transuterine vaginal biopsy technique in uterine fibromatous disease

Conditions: Uterine Fibroids (UF)

Summary: the benign uterine fibroid is part of the broader term uterine smooth muscle tumour, which also includes malignant myometrial tumours (msts) of varying malignancy (uterine sarcoma, cellular fibroid, stump (uterine smooth muscle tumours of uncertain malignant potential)). magnetic resonance imaging (mri) is the most effective test for distinguishing a fibroid from a tmm, but its reliability is limited. this leads to inappropriate management in a number of situations. the first is the risk of overtreatment by performing surgery for a suspected tmm on mri in a patient with few or no symptoms and a final histological diagnosis of fibroid. the second is the risk of unsatisfactory or even harmful cancer surgical treatment in a symptomatic patient with a reassuring mri diagnosis but a final histological diagnosis of tmm. finally, there is the possibility of treating a lesion labelled as a fibroid on mri with an alternative technique (embolisation, radiofrequency, hifu) when it is in fact a tmm, thereby delaying appropriate treatment and worsening the prognosis. ultrasound-guided transuterine vaginal biopsy (etvb) is an innovative and promising minimally invasive technique for preoperative anatomopathological diagnosis. it would make it possible to obtain a histological diagnosis without the need for surgery, thereby avoiding the inappropriate management described above. the aim of this study is to validate an innovative minimally invasive surgical technique (bvte) for the diagnosis of uterine smooth muscle tumours by biopsy, to assess the complications associated with the technique and any potential adverse effects, and to evaluate the feasibility of the technique in current practice.


Eligibility criteria:
inclusion criteria: * patients over 18 years of age consulting the chu de la conception who require surgical treatment for uterine smooth muscle tumours (fibroma or tmm). * able to give written consent * beneficiary or beneficiary of a social security scheme exclusion criteria: * person in a period of exclusion from another research protocol at the time of signing consent/no objection * subjects covered by articles l1121-5 to 1121-8 of the public health code, i.e. : * pregnant women, women in labour and nursing mothers * persons deprived of their liberty by judicial or administrative decision * persons subject to psychiatric monitoring under articles l3112-1 and l3113-1 who are not covered by the provisions of article l1121-8 * minors * adults subject to a legal protection measure or unable to express their consent. * a person who does not have a sufficient command of reading and understanding the french language to be able to consent to participate in the research. * any other reason which, in the opinion of the investigator, could compromise the safety of the research participant and/or interfere with the evaluation of the objectives of the research.
insulin, neurogenetics and memory in alzheimer's disease

Conditions: Alzheimer Disease

Summary: this study examines the use of insulin-sensitizing compounds, as therapeutic agents for cognitive impairment in alzheimer's disease.


Eligibility criteria:
men and women with mild alzheimer's disease without serious medical or psychiatric comorbid conditions.
mixture of prebiotics on intestinal microbiota of patients receiving abdominal radiotherapy.

Conditions: Prebiotics; Microbiota; Radiation Therapy Complication; Endometrial Neoplasms

Summary: abdominal and pelvic radiotherapy (rt) reduces the renewal capacity of the epithelium. rectal biopsies obtained from patients receiving pelvic rt have revealed atrophy of surface epithelium, acute cryptitis, crypt abscesses, crypt distortion and atrophy, and stromal inflammation. modifications in intestinal microbiota, such as an increase in the number of pathogens, may contribute to intestinal injury. the prebiotic effect of a carbohydrate is assessed by its capacity to stimulate the proliferation of healthy bacteria (bifidobacterium, lactobacillus) rather than pathogenic bacteria (clostridium, e. coli). the hypothesis of the study is that a mixture of inulin and fructooligosaccharide could modulate lactobacillus and bifidobacterium and reduce the intestinal injury in patients affected of gynaecological cancer and treated with abdominal radiotherapy.


Eligibility criteria:
inclusion criteria: * female gender, age ≥ 18 years, and a diagnosis of gynaecologic cancer requiring postoperative pelvic rt. exclusion criteria: * previous rt, previous or adjuvant chemotherapy, other types of pelvic tumours or other gynaecologic malignancies, antibiotic or immunosuppressive treatment one week before inclusion or during treatment, and the presence of acute or chronic gastrointestinal disease contraindicating ingestion of the fibre

Keywords: prebiotics microbiota radiotherapy gynaecological cancer
revive ais patients immediately

Conditions: Ischemic Stroke; Occlusion, Cerebrovascular

Summary: this is a multicenter, prospective registry clinical study to evaluate the real-world efficacy and safety of intra-arterial treatment for acute ischemic stroke using revive se device on the basis of standardised medical treatment.

this is a multi-center, prospective, single-arm observational study to evaluate the real-world efficacy and safety of intra-arterial treatment for acute ischemic stroke patients using revive se device on the basis of standardised medical treatment.the device selection before treatment is based upon doctors who are blinded to the protocol. the primary outcomes are reperfusion rate immediately after intervention (mtici score ≥ii b ) and mrs score at 90 days after intervention.

Eligibility criteria:
inclusion criteria: 1. age over 18 years; 2. clinical diagnosis should be acute ischaemic stroke; 3. no more than 6 hours after onset; 4. iv tpa thrombolysis, if needed, should start within 4.5 hours after onset； 5. pre-stroke mrs ≤2; 6. ica/m1/m2/a1/a2/va/ba occlusion confirmed by cta/mra/dsa;' 7. written informed consent form given exclusion criteria: 1. . history of intracranial hemorrhage. 2. . life expectancy \<90 days; 3. . history of major surgery or severe trauma in the past 10 days; 4. . uncontrolled hypertension (defined as: sbp\>185mmhg or dbp ≥110 mm hg at 3 continuous measurements with interval of at least 10 minutes confirm the sbp\>185mmhg or dbp ≥110 mm hg) 5. . plt\<40\*10\^9/l； 6. . blood glucose \ 22. 2 mmol /l； 7. . concomitant use of oral anticoagulation drugs, and inr \>3.0； 8. . aspects score ≤5； 9. . conventional angiography indicates poor collateral circulation (acg score ≤ 1).

Keywords: endovascular treatment mechanical thrombectomy stent retriever human
risk of recurrence after incisional hernia repair with mesh fixation with absorbable versus non-absorbable tacks

Conditions: Incisional Hernia

Summary: laparoscopic incisional hernia repair a variety of fixation methods has been proposed to ensure the correct and stable intra-abdominal placement of the mesh, in order to prevent recurrence, but on the other hand avoiding long-term pain and discomfort. the optimal method is unclear. in denmark the investigators have a nationwide database that records 80% of all ventral hernia repairs. the investigators combine data from the danish hernia database, the national patient registry, and prospective questionnaire and clinical follow-up in order to get the true recurrence rate (clinical and reoperation rate) and the degree of long-term discomfort. purpose the purpose of this national prospective kohort study is to compare the risk of developing recurrence of incisional hernia after laparoscopic incisional hernia repair with either absorbable or non-absorbable tacks, and to investigate possible. late complaints in terms of pain and discomfort after the two mesh fixation devices. the investigators include 355 laparoscopic incisional hernia repairs with absorbable tacks and 726 with non-absorbable tacks. it is expected that about 300 patients will be offered physical examination. material and method register-based cohort study of perioperative entry of patient data and prospective questionnaire follow-up and depending on the answer to any. clinical trial. follow-up is done by searching the danish hernia database and the national patient register (to ensure data completeness) and distribution of patient questionnaire as reoperation for hernia recurrence is an underestimate of the true recurrence risk. statistics there will be performed frequency analyzes and kaplan meyer statistics on the 2 groups supplemented with multivariate cox regression analysis. using non-parametric statistics. p \<0.05 considered statistically significant.


Eligibility criteria:
inclusion criteria: * laparoscopic incisional hernia repair with absorbable or non-absorbable tack mesh fixation. * registered in the danish hernia database * willing to participate in the study and complete the questionnaire exclusion criteria: * lost to follow-up * emigration

Keywords: incisional hernia mesh fixation absorbable tacks