Kornimate/medical-research-clean huggingface dataset:
evaluation of the prognostic role of the systemic immune inflammation index in postmenopausal osteoporosis

Conditions: Osteoporosis, Postmenopausal; Osteoporotic Fractures

Summary: this study is a retrospective case-control study. in the study, the data of 304 patients who were evaluated in our clinic between january 2017 and january 2020 with a pre-diagnosis or diagnosis of postmenopausal osteoporosis were retrospectively reviewed. lumbar 1-4 and femoral neck bone mineral densitometry values t scores, ages, sedimentation, c-reactive protein, neutrophil, leukocyte and platelet levels, and mean platelet volume values of the patients were recorded. the neutrophil-lymphocyte ratio was calculated by dividing the neutrophil count by the lymphocyte count, and the platelet-lymphocyte ratio was calculated by dividing the platelet count by the lymphocyte count. the systemic immune inflammation index (sii) was calculated using the formula, sii = platelet count x neutrophil count / lymphocyte count. the aim of this study is to evaluate the prognostic value of the systemic immune inflammation index in postmenopausal osteoporosis and to examine the sii, n / l, plt / l, mpv, sedimentation (esr), c reactive protein (crp), femur and lumbar bmd values and their relationships with each other.


Eligibility criteria:
inclusion criteria: * having applied to our clinic with the diagnosis or pre-diagnosis of postmenopausal osteoporosis or osteoporosis with pathological fractures exclusion criteria: * having a diagnosis of osteoporosis due to conditions other than postmenopausal osteoporosis * those with acute or chronic infection, malignancy and systemic diseases that may change the hematological inflammation parameters to be checked * persons who are missing one or more of the parameters planned to be considered among the obtained data
short- and long-term impact of subtotal parathyroidectomy on the achievement of bone and mineral parameters recommended by clinical practice guidelines in dialysis patients

Conditions: Hyperparathyroidism

Summary: the impact of parathyroidectomy (ptx) on the bone mineral parameters in dialysis patients with secondary hyperparathyroidism (shpt) remains unclear. the investigators performed this study to present the short- and long-term impact of ptx on calcium, phosphorus and intact parathyroid hormone control in dialysis patients with severe shpt after operation. in particular, the investigators evaluate the impact based on the achievement of recommendations of the current clinical practice guidelines for bone and mineral parameters in dialysis patients after ptx.

1. a retrospective chart review of dialysis patients including referred cases, receiving surgical ptx, which was performed by one surgeon at the far eastern memorial hospital, a 1084-bed tertiary-care medical center in northern taiwan will be performed. 2. serum levels of calcium, phosphorus and intact parathyroid hormone were routinely measured for three consecutive post-operative days and subsequent laboratory values were checked during out-patient follow-up period. patients with postoperative 6-month laboratory data are included in the short-term group and those with more than 6-month available data are in the long-term one. 3. the national kidney foundation kidney disease outcomes quality initiative (nkf-k/doqi™) clinical practice guidelines provided recommended target values for serum intact parathyroid hormone (ipth)(150-300 pg/ml), phosphorus (3.5-5.5 mg/dl), calcium (8.4-9.5 mg/dl) and the calcium-phosphorus product (\<55 mg2/dl2). the kidney disease: improving global outcomes (kdigo) clinical practice guidelines suggested maintaining serum calcium in the reference range (8.5-10.5 mg/dl), phosphorus (2.7-4.5 mg/dl) and pth values in the range of two to nine times the upper reference limit (130 - 585 pg/ml) in dialysis patients. 4. the investigators evaluated the impact of subtotal ptx on the control of bone and mineral parameters in dialysis patients with secondary hpt as the percentages of cases achieving the recommended k/doqi and kdigo targets.

Eligibility criteria:
inclusion criteria: * dialysis patients * secondary hyperparathyroidism refractory to medical treatment * patients receiving subtotal parathyroidectomy by one surgeon * available laboratory data for at least six months after surgery exclusion criteria: * patients receiving parathyroidectomy other than subtotal type by other surgeon * available laboratory data less than six months after surgery

Keywords: subtotal parathyroidectomy calcium phosphorus parathyroid hormone hyperparathyroidism
intestinal flora and metabonomics of appendicitis

Conditions: Appendicitis; Intestinal Metaplasia; Metabonomics

Summary: the goal of this observational study is to learn about the key bacterial flora and metabolites associated with appendicitis in children. the main questions it aims to answer are: * to screen out the key biomarkers of pediatric appendicitis. * what are the microbial differences in different parts of pediatric appendicitis patients. participants will detect feces using 16s ribosomal ribonucleicacid (16s rrna) gene sequencing technology and differences of the fecal metabolites between healthy children and appendicitis children were analyzed using untargeted metabolomics based on liquid chromatography-tandem mass spectrometry(lc-m s/ms) platform.through the analysis of intestinal bacterial flora and metabolomics association and the differential analysis of intestinal bacterial flora in different parts of the case group, the key bacterial flora and metabolites were excavated.

participants will detect feces using 16s ribosomal ribonucleicacid (16s rrna) gene sequencing technology and differences of the fecal metabolites between healthy children and appendicitis children were analyzed using untargeted metabolomics based on liquid chromatography-tandem mass spectrometry(lc-m s/ms) platform. differences in the intestinal flora of different parts of the case group: the intestinal flora of the case group in feces and rectum were detected by 16s ribosomal ribonucleicacid (16s rrna) gene sequencing technology, and the intestinal flora of different parts were analyzed and compared. through the analysis of intestinal bacterial flora and metabolomics association and the differential analysis of intestinal bacterial flora in different parts of the case group, the key bacterial flora and metabolites were excavated.

Eligibility criteria:
inclusion criteria: * children aged 1-14 years who were initially diagnosed with appendicitis and underwent laparoscopic appendectomy * children aged 1-14 years with non-digestive tract disease and no history of digestive tract disease exclusion criteria: * a family history of intestinal disease * allergic to antibiotic therapy drugs * patients with long-term drug use causing microbial structure changes or intestinal flora disorders * patients with other congenital diseases such as meckel's diverticulum, intestinal rotation and other malrotation * with other systemic diseases, such as obvious upper respiratory tract infection or myocarditis * children with other digestive system diseases after auxiliary examination or surgical diagnosis
sensor-based balance training in diabetes: a virtual reality paradigm

Conditions: Diabetes

Summary: diabetic peripheral neuropathy (dpn) can severely deteriorate balance and gait in patients, thereby increasing risk of fall and injury. the aim of the study is to evaluate the efficacy of a virtual reality game based exercise training for improving postural body sway and gait in diabetes patients with peripheral neuropathy. the exercise training has been specifically designed for dpn patients with lost lower extremity joint perception and uses state-of-the-art inertial sensors (body-worn) to acquire joint movement and provide real-time joint feedback through an interactive interface on a lcd monitor. the investigators hypothesize that tailored exercise with real-time visual joint feedback during exercise will reduce improve balance and gait.

the game includes a series of ankle reaching tasks and crossing of virtual obstacles on the monitor screen; these exercises are aimed to improve weight shifting capabilities and medial-lateral movement of body.

Eligibility criteria:
inclusion criteria: * diabetic peripheral neuropathy * age \> 50 (men or women) * able to walk 60 feet exclusion criteria: * major lower extremity amputation * cognitive deficits (mmse 24 or below) * severely impaired vision

Keywords: postural balance gait fall risk
a retrospective cohort study of differential attainment, covid-19 and chaos

Conditions: Surgery; COVID-19

Summary: a retrospective cohort study of differential attainment, covid and chaos: taking the difference out of a terrible trinity

background: this study aimed to evaluate core surgical training (cst) differential attainment (da) related to covid-19 and gender in three ethnic cohorts: white uk (wukg), black \& minority ethnic uk (bmeukg), and international medical graduates (img). the hypothesis was that covid-19 adversely influenced cst outcome. methods: anonymised 234 cst and 37 ist records (152 wukg, 81 bmeukg, 38 img) in a uk statutory education body (seb) were examined. primary effect measures were: annual review of competency progression outcome (arcpo), mrcs pass, and national training number (ntn) appointment.

Eligibility criteria:
inclusion criteria: * cst exclusion criteria: * not completed training

Keywords: core surgical training differential attainment covid-19
magnesium sulfate combined with intraarticular cocktail injection for analgesia after simultaneous bilateral total knee arthroplasty

Conditions: Osteoarthritis, Knee

Summary: total knee arthroplasty is a safe procedure with excellent outcome. in recent years, simultaneous bilateral total knee arthroplasty has become more popular. in views of enhanced recovery after surgery, intraarticular cocktail injection for pain control has been developed. however, the safety accumulation dose for simultaneous bilateral knee injection is still an issue. recently, adding magnesium sulfate to intraarticular cocktail injection in unilateral total knee arthroplasty has been proved effective for prolong pain control. we tempt to conduct a double blinded study to evaluate that whether adding magnesium sulfate intraarticular cocktail injection to one of the knees in simultaneous bilateral total knee arthroplasty patient could effectively decrease pain score with less analgesia dose or not.


Eligibility criteria:
inclusion criteria: * bilateral knee advanced osteoarthritis or osteonecrosis who tend to receive simultaneous bilateral total knee arthroplasty exclusion criteria: * hypersensitivity to magnesium sulfate * hypermagnesemia * severe cardiac, hepatic or renal compromised

Keywords: intraarticular injection
lifestyle vs.surgery for morbid obesity treatment

Conditions: Morbid Obesity

Summary: the purpose of the current study is to determine whether an intensive lifestyle intervention was as effective as surgery to treat morbid obesity nine years post-intervention.

behavioral/lifestyle interventions produce acceptable success in treating moderately obese subjects. however, their effectiveness on weight loss and maintenance in morbidly obese subjects remains elusive. twenty-nine morbidly obese females participated in this non-randomized study. fifteen subjects were assigned to the lifestyle group and 14 underwent vertical banded gastroplasty. subjects in the lifestyle group attended 30 behavioral modification sessions over three years, whereas the surgery group received the standard of care nutrition. body weight, resting metabolic rate, physical activity, body composition measurements and dietary intake data were assessed at standard time points during the first 3 years post-intervention. follow-up data on body weight and physical activity were also collected 9 years later.

Eligibility criteria:
inclusion criteria: * female sex * age ≥ 18 years * bmi ≥ 40 kg/m2 * absence of mental illness as determined by evaluation by an experienced psychiatrist * additional inclusion criteria for vertical banded gastroplasty were history of multiple, non-successful, previous attempts for weight loss

Keywords: lifestyle intervention bariatric surgery weight management physical activity
brain health fitness program: exercise for people with mild-moderate cognitive impairments

Conditions: Cognitive Impairment

Summary: the goal of this clinical trial is to test a 6-month, twice a week, moderate intensity exercise and coaching program (an in-person group and a distance group) for adults with mild-moderate cognitive impairments living in south carolina. the main questions it aims to answer are: 1. is the program practical to conduct, and it is acceptable and enjoyable? the hypothesis is that it will be possible to recruit participants, obtain the desired dosage of moderate intensity fitness and strength training twice a week. 2. are their changes at 3-months and 6-months in endurance, mobility, cognitive function and perception of cognitive function? the hypotheses are that endurance, strength and mobility will improve and cognitive measures will not decline (remain the same or improve). participants will exercise twice a week in-person with a coach or at a distance location with coaching support for six months.

in person exercise group: the exercise program interventions will be individualized based on exercise history, and initial assessments by the primary investigator (a physical therapist). the program will focus on building up to 30 minutes of moderate intensity endurance activity and up to 30 minutes of strength training, balance training and mobility training. participants will attend times per week for six months. coaches will provide exercise plans, and monitor and provide feedback as participants exercise. participants will wear a heart rate monitor to record exertion. participants will be able to continuously attend as long as they are attending regularly. distance exercise group: the exercise program interventions will be individualized based on exercise history, and initial assessments by the primary investigator (a physical therapist) which will occur in person. the program will focus on building up to 30 minutes of moderate intensity endurance activity and up to 30 minutes of strength training, balance training and mobility training. participants will exercise on their own 2 x a week for 6 months.coaches will prescribe an exercise program that can be performed at a local fitness facility or at home and it will be shared through a coaching software. participants will log their exercises either in the coaching software or in paper formats, have weekly check-ins with fitness center coaches and have options to message the fitness center coaches with questions. participants who do not log any activity and miss weekly check-ins will have follow up from fitness center coaches.

Eligibility criteria:
inclusion criteria: * medical diagnosis of mild-moderate cognitive impairment * medically cleared for exercise * able to follow 2-step commands exclusion criteria are significant pain with movement (\>5/10) exclusion criteria: * significant pain with movement (\>5/10) * severe balance impairments or lack of independence on and off exercise equipment (by physical therapist judgement).

Keywords: cognitive impairment exercise
intervention targeting substance using older adults with hiv

Conditions: HIV; Medication Adherence; Substance Dependence

Summary: the proposed study uses a randomized controlled experimental design to evaluate the efficacy of a brief intervention using spiritual self schema (3s+) counseling to simultaneously target hiv health outcomes, and substance use among alcohol and/or drug dependent hiv positive older adults (age 50+), relative to an attention control condition. participants will be randomly assigned to receive either: (1) 12 sessions of 3s+ counseling, adapted for the present study to target both non-injection drug use, drinking, and hiv health; or (2) 12 sessions of education about hiv health and the associated with alcohol and drug use that will serve as an attention-control.


Eligibility criteria:
inclusion criteria: * hiv+ (provide hiv medication bottle with name on it) * age 50 or older (provide picture id with dob at baseline) * report current alcohol/drug dependence (audit score of 8 or dast-10 score of 4 on screener; c-dis at baseline) * on a prescribed haart medication regimen and reports sub-optimal adherence (self-report missed at least 3 days in last 30 at 1 pill/day that is 90%) * communicate with staff and complete a survey in english or spanish (english only for the pilot) exclusion criteria: * current intravenous drug use (self-report at screener and baseline) * currently in a methadone drug treatment program (screener self-report) * unstable, serious psychiatric symptoms (scid-psych at baseline) * currently suicidal/homicidal (scid-psych at baseline) * gross cognitive impairment (mini-mental at baseline) * current enrollment in alcohol/drug treatment or hiv study (screener self-report)

Keywords: hiv medication adherence substance use older adults treatment
predictive markers of glitazone efficacy in diabetic patients - pilot study

Conditions: Diabetes Mellitus, Type 2

Summary: hypothesis: a cluster of biochemical measurements (biomarkers) predict which diabetic patients will respond to treatment with a therapeutic dose of rosiglitazone over a 12 week treatment period. brief summary: the purpose of this study is to assess the predictive value of the biomarkers in diabetic patients treated with a full dose of a thiazolidinedione (eg 4mg bid rosiglitazone) for 12 weeks. specifically - the questions asked are: 1. do baseline measurements of a selected panel of biomarkers predict the patients' response to rosiglitazone over 12 weeks? 2. how does the panel of biomarkers change over that 12 week treatment period?

rosiglitazone (avandia) is a medicine used to treat type 2 diabetes. it works by increasing the sensitivity of body tissues to insulin. this pilot study will examine the possibility that baseline biochemistry might predict the response to rosiglitazone. the study will be conducted in males and the biomarkers of interest measured by specific assays. in addition, since the biomarkers to be measured come from body fat, interpretation of the data would be facilitated by accurate measurements of changes in body fat mass during treatment and these data can be obtained from echo-mri scans.

Eligibility criteria:
inclusion criteria: 1. male subjects aged 18 to 65 years. 2. eligible subjects must be free from clinically significant illness or disease (other than type 2 diabetes)with the exception of chronic stable-treated hypertension (bp\ 90/50), thyroid disease (tsh in the normal reference range) and/or dyslipidaemia. 3. bmi must be \> or = 25kg/m2 to \< or = 40kg/m2, 4. hba1c between 7and 10%, fasting blood glucose above 7mmol/l (fasting means greater or = 8 hours prior to screening). 5. on diet alone or diet plus metformin (gsk data indicate that the latter group more faithfully reflect the behaviour of 'naive' patients than those who have been washed off prior medications)for at least 1 month. 6. on stable doses of anti-hypertensive medication, thyroid hormone replacement and statin therapy as required. exclusion criteria: 1. prior treatment with thiazolidinedione, insulin or glp-1 analogue (byetta) 2. history of hepatic disease, impairment or abnormal liver function test i.e. ast, alt\>2 times upper limit of normal range (uln), bilirubin\>1.5 time uln. history of renal disease or serum creatinine greater than 1.5 x uln. 3. contraindications to rosiglitazone treatment. 4. serum creatinine greater than 1.5 x upper limit of normal range. 5. any other clinically significant laboratory abnormality. 6. claustrophobic or other contraindication to mri scan 7. females of child-bearing age who are unwilling to use appropriate methods of contraception. 8. unable to give informed consent. 9. unable to comply with study protocol. 10. clinically significant co-morbidity. -

Keywords: biomarker glitazone diabetes
peculiarities of pain in patients with gunshot wounds depending on the localization of the wound at the stages of treatment

Conditions: Chronic Pain

Summary: chronic pain, in turn, is associated with a whole cohort of mutually aggravating factors - this can lead to the development of extremely serious long-term consequences. the features of pain in this category of patients have not been sufficiently studied. taking into account continuity and consistency, clear and high-quality pain treatment is necessary at all stages of treatment.

the peculiarities of pain in patients with gunshot wounds, depending on the localization of the wound at the stages of treatment, need to be studied, because the subjective feelings and emotional experiences experienced by patients during the wounding in combat conditions through the prism of psychological disorders have their own characteristics.

Eligibility criteria:
inclusion criteria: * the presence of gunshot wounds exclusion criteria: * no gunshot wounds

Keywords: pain
effectiveness of conversion to sirolimus versus calcineurin inhibitor (cni) reduction in renal transplant patients with prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this study is to evaluate the role and effectiveness of conversion to sirolimus versus cni reduction in renal transplant patients with prostate cancer.

this study is designed to support the optimal use of mtor-inhibitor by providing data for the safe and effectiveness use with sirolimus. this study will take into account effectiveness aspects such as malignancy-free survival cancer by reducing the overall exposure to calcineurin inhibitor.

Eligibility criteria:
inclusion criteria: * male patients ≤ 50 years in their post renal transplant follow-up; * biopsy confirmed prostate cancer; * stable renal function with gfr ≥ 40 ml/min. exclusion criteria: * patients with metastatic disease; * uncontrolled hyperlipidemia; * proteinuria \> 500 mg/day; * biopsy evidence of acute rejection within the past 3 months; * existence of any surgical or medical condition, other than the current transplant, which in the opinion of the investigator might significantly alter the absorption, distribution, metabolism or excretion of study medication; * patients with mental illness; * inability to cooperate or communicate with the investigator or unable to complete self administered questionnaires.

Keywords: sirolimus calcineurin inhibitor prostate cancer
the effect of dry needling and prolotherapy on pain, function, and quality of life in patients with cervical radiculopathy.

Conditions: Cervical Radiculopathy

Summary: cervical radiculopathy is characterized by neurological dysfunction caused by compression and inflammation of the spinal nerves or nerve roots of the cervical spine. rolotherapy is a regenerative therapeutic method that consists of injecting irritant solutions into the injured areas.

hyperosmolar dextrose is the most common agent. administering proliferant substances can accelerate the tissue healing process by inducing cellular rupture and inflammatory response, leading to collagen deposition, cellular growth factor production, and regeneration. dry needling used to relieve trigger point release in deep and superficial muscles. both treatment interventions will apply to cervical radiculopathy patients to measure the effectiveness of treatment.

Eligibility criteria:
inclusion criteria: * age group between 20-50 years * both male and female * unilateral pain starting in the cervical spine and radiating to the upper limb. * pain aggravated by upper limb movement * restricted range of motion of arm exclusion criteria: * history of spinal infection * spinal cord injury * history of vertebral tumor and factures * history of cervical or intracranial surgery * history of radiating pain to bilateral upper limb.