Kornimate/medical-research-clean huggingface dataset:
treating tobacco dependence in adolescents with co-occurring psychiatric disorders

Conditions: Tobacco Use Cessation; Tobacco Use Disorder

Summary: this research aims to identify efficacious strategies for treating tobacco dependence among adolescent smokers with co-occurring psychiatric disorders. adolescent smoking remains a significant public health issue with 23% of high school students reporting smoking a cigarette in the past month1. smoking rates are two to four times higher among adolescents with psychiatric disorders such as attention deficit disorders, conduct disorder, depression, anxiety disorders, and alcohol and illicit drug dependencies2-4. empirical investigations of adolescent tobacco treatment interventions number less than 50 with many of the studies criticized for methodological problems (i.e., follow up \< 6 months, poor retention, lack of control or comparison groups)2,5, 6. there have been no unequivocal successes; however, promising interventions include stage-based, cognitive behavioral (cbt), and multicomponent treatments2, 7. additionally, the nicotine patch is well tolerated and safe among adolescents8 and rarely abused9. less than a third of adolescent tobacco users report intention to quit in the near future2, 10, 11; thus, it seems critical that cessation interventions for this complex group be designed to assist smokers at all stages of readiness through the quitting process. a stepped care approach has the potential of matching more intensive services to those ready for and in need of greater treatment. interventions delivered in health care settings have the appeal of broad reach. the primary specific aims of this research are to evaluate, in a randomized clinical trial (n=160), the efficacy of a stepped care intervention for treating smoking among adolescents recruited from outpatient psychiatry settings. to our knowledge, this would be the first study to examine outpatient psychiatry settings for treating tobacco dependence in adolescents. the stepped care intervention combines expert-system contacts, individual cbt sessions, and 12-weeks of nicotine replacement therapy (nrt).


Eligibility criteria:
inclusion criteria: * receiving active outpatient psychiatric care * report smoking at least 1 cigarette in the previous 30 days and at least 100 cigarettes in their lifetime * other inclusion criteria are: no plan to relocate outside of the greater san francisco bay area in the next 12 months and telephone access for scheduling follow up assessments. exclusion criteria: * cognitive impairment precluding ability to participate * non-english speaking * currently engaged in tobacco treatment * recruitment of acutely psychotic, manic, or hostile patients will be delayed until there is significant reduction of these symptoms and patients are able to assent to study participation
impact of swallowing impairment on individuals with parkinson disease

Conditions: Parkinson Disease; Dysphagia

Summary: in this online study, investigators will explore the psychosocial burdens of swallowing difficulties in people with parkinson's disease. this study is completely virtual, so you can participate from wherever you live in the united states. participation requires you to complete a one-hour zoom interview and a brief questionnaire. you will be compensated with a $25 walmart gift card. to learn more, please use the "send email" feature. thank you!

this is a mixed methods study. the investigators will collect qualitative data from participants by conducting 1-2 hour semi-structured interviews on zoom. the interview questions are designed to systemically inquire about patient experiences, affective reactions, coping strategies, social support, self-identity issues, and treatment experiences. the investigators will collect quantitative data by asking participants to complete the brief illness perception questionnaire. the data will be analyzed using a comprehensive stress and coping model, which has not been done previously in the field. the investigators hope to discover themes about psychosocial burdens and related coping mechanisms.

Eligibility criteria:
inclusion criteria: * participants must currently have oropharyngeal dysphagia and parkinson disease * participants must be at least 18 years of age * participants must speak english. exclusion criteria: * participants whose receptive and expressive language skills will not allow them to participate in one-on-one interviews
evaluating a novel medication device for methadone dosing

Conditions: Opioid-use Disorder

Summary: this study will evaluate whether a commercially available, secure, electronic pill box is a feasible, acceptable, and satisfactory method to manage take-home dosing of methadone for both methadone clinic patients and staff members.


Eligibility criteria:
inclusion criteria: * 18 years or older * receiving methadone for the treatment of opioid use disorder for at least 90 days and having been on the same methadone dose for at least 30 days * have previously received a take-home dose of methadone as part of routine care * be willing to comply with the study schedule * be a methadone patient in the clinic within which this study is being conducted exclusion criteria: * pregnancy * presence of an acute medical problems that requires immediate or intense medical management * presence of serious or unstable mental illness that interferes with study procedures * planning to leave methadone treatment within the next 12 weeks * being maintained on a dose of methadone that is less than 10mg or more than 100mg * currently receiving split doses of methadone as part of routine care
the relationship of change of dendritic cells fractalkine and p-selectin patients with acute myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: this study evaluates the relationship of change of dendritic cells fractalkine and p-selectin in patients with acute myocardial infarction.

dendritic cells (dcs) are the most potent antigen-presenting cells, with the unique ability to initiate a primary immune response to certain antigens by activation of "naive" t cells, and are actively related to the process of atherosclerosis. two dc subsets, myeloid dcs (mdcs) and plasmacytoid dcs (pdcs), were identified in humans. in our previous study, the investigators found that change of dendritic cells and fractalkine in patients with acute myocardial infarction. at the same time, the level of p-selectin increased. in addition, the interaction of dendritic cells and p-selectin promotes the progress of atherosclerosis. in this study, the investigators want to see whether the balance between mdcs and pdcs is altered in patients with acute myocardial infarction. sp-selectin is one of the members of the family of proteins, mediate leukocyte adhesion and rolling in vascular endothelial, studies have shown that in patients with unstable angina and acute myocardial infarction in serum sp-selectin protein increased significantly, showed that sp-selectin associated with the activity of coronary heart disease, causing plaque instability.however, there is few relevant studies about the relationship of dendritic cells and p-selectin in patients with acute myocardial infarction. this study valuates the relationship of dendritic cells and p-selectin in patients with acute myocardial infarction

Eligibility criteria:
inclusion criteria: * diagnosed as stemi. * with left ventricular ejection fraction（lvef）\>=45% * written informed consents are obtained. * admitted within 24 hours after chest pain attacked. exclusion criteria: * obvious blood system diseases. * combination with other organs function failure: severe liver dysfunction, severe renal insufficiency,severe heart failure (nyha class 3 and 4), acute or chronic infectious diseases, disease of immune system, asthma, malignant tumor, other advanced disease, etc. * pregnant women and planned pregnancy women. * with drug allergy or contraindications. * refusal to sign the informed consent

Keywords: dendritic cells p-selectin
phase i study of gw572016 with topotecan to treat advanced solid malignancies

Conditions: Advanced Solid Malignancies

Summary: participants will take gw572016 by mouth daily each cycle (cycles 28 days in length) and will be given topotecan intravenously on days 1, 8 and 15.

participants will take gw572016 by mouth daily each cycle (cycles 28 days in length) and will be given topotecan intravenously on days 1, 8 and 15. during cycle 1 participants will be required to spend the evening before day 1 in the general clinical research center and frequent blood samples will be drawn on day 1; this schedule will be repeated the evening of day 6 with the blood samples drawn on day 7. participants will have weekly cbcs.

Eligibility criteria:
age 18 and older histologic proof of cancer that is unresectable anc greater than 1500 u/l plc greater than 100,000 u/l total bilirubin less then or equal to uln ast less than 3 x uln or ast less than 5 x uln if liver involvement creatinine less than 1.5 x uln hemoglobin greater than 9 g/dl echocardiogram with ejection fraction great than 40% life expectancy of more than 12 weeks
get in touch phase 2

Conditions: Diabetes Mellitus, Type 2

Summary: the objective of the get in touch - phase 2 (git-2) study was to evaluate a diabetes care support intervention facilitated by cellular-enabled glucose meters in adults with persistent poor control of type 2 diabetes.

a 2-group randomized crossover trial comparing usual care to a diabetes care support intervention among patients with repeated hba1c recordings greater than 8.0 percent during the previous 12 months. the intervention included 6 months of enrollment in livongo for diabetes, a certified diabetes educator (cde) based remote diabetes monitoring program facilitated by cellular-enabled glucose meters, with additional remote monitoring by their usual care team. hba1c levels were recorded at enrollment and 3, 6, 9, and 12 months post enrollment. questionnaire data were collected at baseline, 6 months, and 12 months post enrollment. primary outcomes evaluated were change in hba1c and treatment satisfaction at the 6 month endpoint with secondary outcomes of change in hba1c and treatment satisfaction at the 12 month endpoint.

Eligibility criteria:
inclusion criteria: * speak english, having type 2 diabetes with two consecutive hba1c recordings greater than 8.0% over the previous 12 months at the time of recruitment exclusion criteria: * excluded if they were cognitively impaired, pregnant, or prisoners.
an observational study of mabthera/rituxan (rituximab) plus chemotherapy as first-line treatment in patients with diffuse large b-cell lymphoma or follicular lymphoma

Conditions: Diffuse Large B-Cell Lymphoma

Summary: this observational study will evaluate the safety and efficacy of mabthera/rituxan (rituximab) plus chemotherapy as first-line treatment in patients with diffuse large b-cell lymphoma (dlbcl) or follicular lymphoma (fl). data will be collected from each patient during the 6 months of induction treatment and for up to 3 years of follow-up.


Eligibility criteria:
inclusion criteria: * histologically confirmed cd20+ diffuse large b-cell lymphoma or follicular lymphoma * treatment with mabthera/rituxan as per locally approved china package insert * documented patient with medical records exclusion criteria: * previous treatment for diffuse large b-cell lymphoma or follicular lymphoma
occurrence of traumatic dental injury in a group of egyptian autistic children compared to normal children: (a cohort study)

Conditions: Traumatic Dental Injury; Autism Spectrum Disorder; Dental Trauma

Summary: the aim of the study is to assess the occurrence of traumatic dental injury in a group of egyptian autistic children compared to normal children. population: egyptian children exposure: autistic children. control: normal children. outcome: primary outcome: occurence of traumatic injury. secondary outcome: risk factor, oral habits.

this study is a cohort study, the study group compromise a group of children with asd, the control group compromise a group of normal children. study group will be recruited from abbaseya mental health hospital and advance center for handicapped and autistic children. control group will be recruited from diagnosis clinic of pediatric dentistry and dental public health department at faculty of dentistry cairo university. the investigator will make an interview with the parents of both groups to fill the a questionnaire (taken from different articles, modified by the investigator to accommodate the aims of the study.) then they will be assigned informed consent, children whose parents agreed to participate in the study were recruited. inclusion criteria: * autistic and normal children. * children aged from 6 to 12 years old irrespective of sex. exclusion criteria: * behavior of the child is inadequate. * children with dental structural defect. * parents that refused to give informed consent.

Eligibility criteria:
inclusion criteria: * autistic and normal children. * children aged from 6 to 12 years old irrespective of sex. exclusion criteria: * behavior of the child is inadequate. * children with dental structural defect. * parents that refused to give informed consent.

Keywords: autism traumatized teeth in autistic children occurrence of dental trauma
mri findings in throwing shoulders of waterpolo players

Conditions: Waterpolo Players; Non Throwing Shoulders

Summary: mri examination of 60 shoulders of waterpolo players (30 throwing shoulders as well as the opposite side) and 15 healthy probands as control group (30 shoulders of non waterpolo players. the correlation of mri alteration and clinical symptomatic findings in both groups will be investigated. the clinical examination is performed by 2 board certified orthopedic surgeons and based on the constant murley score.


Eligibility criteria:
inclusion criteria: * study shoulders of elite waterpolo players * study shoulders of healthy non throwing persons * age between 18-35 years * male * given informed consent exclusion criteria: * previous shoulder surgery * goal keeper * metallic implants * pacemaker * tattoos with metallic colors
effect of parental presence on anxiety of children during induction of anesthesia

Conditions: Anxiety; Preoperative Anxiety

Summary: anxiety is when children feel scared, worried, or nervous before or during anesthesia induction. this can happen because they don't know what's happening, are scared of the hospital or medical equipment, or are worried about being separated from their parents. when parents are present, they can: * provide emotional support and reassurance * distract the child from scary things * help the child feel more calm and safe this can help reduce the child's anxiety levels. when parents are not present, children may feel: * more scared and anxious * alone and unsupported * more worried about what's happening this can increase the child's anxiety levels. we can prepare children and parents beforehand about what will happen * allow parents to be present during anesthesia induction * use distraction techniques like toys or videos * use gentle and calm anesthesia induction techniques by doing these things, we can help reduce anxiety in children and make the experience less scary for them.

induction of pediatric anesthesia represents a highly stressful event for children, often resulting in preoperative anxiety that can impair the child's perioperative experience and result in adverse postoperative outcomes. it has been proposed that parental presence during induction of anesthesia preoperative anxiety is linked to postoperative maladaptive behaviors, such as pain following surgery, insomnia, conflicts between the child and his parent, separation anxiety, increased urinary frequency during the night, reduced appetite, lack of interest, agitation, and alienation.may be a non-pharmacologic intervention to reduce children's anxiety. in patients with extreme anxiety, unfavorable postoperative behaviors after anesthesia induction are likely to result in long-term issues, which adversely affect the process of recovery, and also develop a feeling of inadequate care. parental presence at anesthesia induction is the interaction that takes place in the induction room during the course of anesthesia induction between the child, parent, anesthesiologist, and perioperative nurses.

Eligibility criteria:
inclusion criteria: * pediatric patients * aged 5-10 years * minor surgery * duration \<1 hour * asa 1 and asa 2 patients exclusion criteria: * patients and attendant refusal * emergency surgeris * renal insuffciency * age less than 5 and more than 10 years

Keywords: pre-operative anxiety, minor surgery, parental presence during induction of anesthesia modified yale preoperative anxiety scale
congenital heart defects

Conditions: Congenital Heart Defects

Summary: describe the relationship between maternal diabetes and congenital heart defects in infants born to diabetic mothers referred to nicu unit \& outpatient clinics of assiut university childeren's hospital.we will compare between 2 groups. cases will represent infants of diabetic mothers \& conteols will represent infants of non-diabetic mothers.

congenital heart disease is defined as a gross structural abnormality of the heart or intra-thoracic great vessels that is actually or potentially of functional significance .the prevalence of chd at birth has been relatively variable at 4.05 to 10.4 cases per 1000 live births in different surveys however,it is 5.0% in infants of diabetic mothers (idms).chd is the most common congenital problem in children accounting for nearly 25% of all congenital malformations .chds are one of the significant causes of infant morbidity and mortality. gestational diabetes mellitus (gdm) is the most common medical complication of pregnancy. it is associated with maternal and neonatal adverse outcomes. maintaining adequate blood glucose levels in gdm reduces morbidity for both mother and baby. pregnancy is associated with insulin resistance (ir) and hyperinsulinemia that may predispose some women to develop diabetes. gestational diabetes has been defined as any degree of glucose intolerance with an onset, or first recognition during pregnancy. diabetes during pregnancy could be a de novo that arises during pregnancy for the first time and could disappear or persist after delivery (gestational dm) or could start as pre-gestational, before the onset of pregnancy. the incidence of impaired glucose tolerance in pregnancy ranges between 3-10% and varies according to the average incidence of diabetes in the general population. specific chds that are more commonly seen in idms include ventricular septal defect (vsd), transposition of the great arteries (tgas), and aortic stenosis (as).approximately one third of neonates with chd require intervention in the first month of life . clinical manifestation of chd varies according to the type of lesion. neonates with respiratory distress , cyanosis, feeding difficulties, and low cardiac output are common presentations of chd . so diagnosis of chd at the earliest possible time is very important as early referral and appropriate intervention in some of these cases are lifesaving.

Eligibility criteria:
inclusion criteria: the study will include infants of diabetic mothers and infants of non-diabetic mothers not previously screened for congenital heart defects. exclusion criteria: other risk factors for congenital heart defects including congenital infections like torch infection, teratogenic drugs ( lithium or isotretinoin), , alcohol, or smoking.
cardiac dysfunction in childhood cancer survivors

Conditions: Cardiac Dysfunction; Cardiovascular Diseases; Childhood Cancer

Summary: this multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. the hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking echocardiography as novel echocardiographic technique compared to conventional echocardiography.

cardiovascular disease including cardiac dysfunction is the leading non-malignant cause of death in childhood cancer survivors. early detection of cardiac dysfunction is important to identify those in need for medical intervention to improve outcome. this study invites adult childhood cancer survivors to a clinical appointment to the university hospital bern, switzerland. a detailed, standardized cardiac assessment including conventional and novel echocardiographic techniques (speckle tracking) as well as cardiopulmonary exercise testing is performed. cardiac dysfunction is evaluated in survivors who have had cardiotoxic cancer therapy with anthracyclines and/or chest radiation (high risk) and in survivors who have had chemotherapy other than anthracyclines (standard risk).

Eligibility criteria:
this prospective cohort study is nested within the childhood cancer registry (chcr), a national, population-based cancer registry that includes all children and adolescents in switzerland who were diagnosed with cancer at age 0-20 years. it includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or langerhans cell histiocytosis. childhood cancer survivors have survived at least 5 years from cancer diagnosis. inclusion criteria: * registered in the chcr * formerly treated at the department of pediatric hematology/oncology of one of five participating centers * treated with any chemotherapy and/or chest radiation * survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination * diagnosed at age ≤ 20 years * ≥ 18 years of age at time of study participation * resident in switzerland * written informed consent exclusion criteria: * study participants will be excluded if they do not meet the above mentioned inclusion criteria or refuse to participate in the study.

Keywords: childhood cancer survivors late effects cardiotoxicity chemotherapy anthracyclines radiation
a study to evaluate the pharmacokinetics and safety between hcp2202 and co-administration of each component in healthy volunteers under fed conditions

Conditions: Healthy

Summary: the purpose of this study is to evaluate the pharmacokinetic characteristics and safety between hcp2202 and co-administration of each component in fed condition in healthy volunteers.


Eligibility criteria:
inclusion criteria: * age 19\~54 years in healthy volunteers 18.5 kg/m\^2 ≤ bmi \< 30 kg/m\^2, weight(men) ≥55kg / weight(women) ≥45kg * 90 mmhg ≤ sbp \<140 mmhg, 50 mmhg ≤ dbp \<90 mmhg * agrees that the person, spouse, or partner uses appropriate medically recognized contraception and does not provide sperm or eggs from the date of administration of the first investigational drug to 7 days after the administration of the last investigational drug. * subjects who voluntarily decides to participate in this clinical trial and agree in writing to ensure compliance with the clinical trial exclusion criteria: * presence of medical history or a concurrent disease that may interfere with treatment and safety assessment or completion of this clinical study, including clinically significant disorders in digestive system, neuropsychiatric system, endocrine system, liver, cardiovascular system * subjects who judged ineligible by the investigator