Kornimate/medical-research-clean huggingface dataset:
esan iii - energy sensing in depression

Conditions: Obesity; Gut Microbiota Modulation; Immunomodulation

Summary: the purpose of this study is to assess the effects of carotenoids from natural carrot juice on the immune system. therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as carotenoids in healthy and depressive individuals, to explore their potential use in therapeutic settings. the consumption of natural fruit juices rich in polyphenols and carotenoids serves as a model for a vegetarian diet, due to the increased micronutrient density derived from plant-based foods. the results obtained may provide preliminary explanatory models for the beneficial effects of a vegetarian diet. it is hypothesized that the consumption of a natural carotenoid-rich juice alters the expression of regulatory t cells-specific immune cells that contribute to immunomodulation. furthermore, beneficial changes in the gut microbiome, metabolome, and nutritional status are expected. this study was registered retrospectively (after recruitment had started) on clinicaltrials.gov.


Eligibility criteria:
inclusion criteria socio-demographic criteria: gender: female age: 18-65 years confirmation of study participation: received information on the aims, methods, anticipated benefits, potential risks, and entailed discomforts of the study signed declaration of consent subgroup of depressive patients: diagnosis of depression according to the icd-10 criteria diagnosis confirmed by an experienced psychiatrist subgroup of normal weight participants: who criteria for normal weight (body mass index \[bmi\] 18.5-24.99 kg/m²) subgroup of obese participants: who criteria for obesity (bmi \> 30.0 kg/m²) exclusion criteria formal criteria: lack of informed consent health criteria: alcohol or drug abuse acute or chronic diseases or infections (including cancer, fever, pneumological or renal disorders, cardiovascular disease, hematopoietic disorders) digestive disorders (including fructose intolerance, inflammatory bowel disease, irritable bowel syndrome) treatment that may have influenced the microbiome (including antibiotic or antifungal treatment within the previous two months, and daily or irregular intake of prebiotics or probiotics within the previous two months; the intake of yogurt and dairy products is permitted) history of gastrointestinal surgery (other than appendectomy) psychiatric disorders (schizophrenia, dementia, bipolar disorder) pregnancy or breastfeeding

Keywords: carotenoids antioxidant effects micronutrient absorption in-vitro digestion intervention study nutrition natural juice
improving health outcomes: blood pressure

Conditions: Hypertension

Summary: this quality improvement project is focused on improving hypertension care delivery processes in ambulatory clinical practices, 5 in illinois and 5 in maryland for a total of 10 practice sites.the primary aim of this quality improvement project is to improve blood pressure control among patients receiving routine care for hypertension in a diverse group of ambulatory clinical practices. a secondary aim is for american medical association (ama) and johns hopkins medicine (jhm) quality improvement staff to figure out the best way to help clinical practices in achieving improved blood pressure control, including working to increase the use of home blood pressure monitoring.


Eligibility criteria:
the practice sites must * self-identify as either primary care internal medicine, family practice, or cardiology * have an electronic health record * serve patient populations that are diverse and representative of the u.s. adult population * have a significant number of male and female patients, age 18 or older, voluntarily receiving care for hypertension * have the resources, staff, and commitment to complete this quality improvement project

Keywords: quality improvement primary care blood pressure, high feedback knowledge
gynaecological gender-affirming surgeries

Conditions: Gender Dysphoria

Summary: the goal of this prospective cohort study is to learn about the patient report outcomes after gynaecological gender-affirming surgeries (i.e. hysterectomy, tubectomy, colpectomy) among trans-masculine and non-binary individuals (assigned female at birth). the main question it aims to answer are: • what is the experienced effect of gynaecological gender-affirming surgeries participants will be asked to fill out a questionaire pre-operatively and 3,9 and 18 months post-operatively.


Eligibility criteria:
inclusion criteria: * assigned female at birth * scheduled to undergo gynaecological gender-affirming surgery (i.e. hysterectomy, ovariectomy, tubectomy and/or colpectomy) exclusion criteria: * age below 18 y/o * surgery combined with other surgeries (e.g. urethroplasty, metoidioplasty)

Keywords: hysterectomy colpectomy vaginectomy tubectomy patient-reported outcome measure
evaluation of use of brain activity monitoring for prediction of migraine attacks

Conditions: Migraine

Summary: this study evaluates the use of brain activity monitoring for prediction of migraine attacks in an expected time scale of 12-48 hours prior to the migraine attack.

the study will be conducted in one are. participants diagnosed with migraine, will be evaluated for their eeg characteristics as well as daily migraine related clinical and general status. participants' monitoring will be conducted for 20 times for a duration of one month.

Eligibility criteria:
inclusion criteria: * diagnosed with migraine by a neurologist. * male or female, aged 18 -50 years. * able and willing to comply with all study requirements. * having 3-10 migraine attacks per month. exclusion criteria: * diagnosed with chronic pain, neurological or psychiatric disorders. * current or past use of anti-depressants. * a user of recreational or illicit drugs or has had a recent history of drug or alcohol abuse or dependence. * history of seizures * head injury with consciousness loss in the last three months. * diagnosed as adhd and/or use of ritalin. * hearing disorder and/or known ear drum impairment. * having migraine attacks occurring only during the menstruation.
symptom management, education and telephone follow-up, quality of life,

Conditions: Prostate Cancer

Summary: this study was planned as an experimental design study with pretest-posttest control group in order to determine the effects of education and telephone follow-up given to patients receiving androgen deprivation therapy (adt) for prostate cancer on quality of life and symptom management.the main question\[s\] it aims to answer are: * is the quality of life higher in patients receiving androgen deprivation therapy who are trained and followed up over the phone compared to patients who are only given an education booklet? * is symptom management higher in patients receiving androgen deprivation therapy who received training and followed-up over the phone compared to patients who were only given an education booklet?

the number of samples to be taken in each group was determined as 24 (total 48) with the help of the g-power (version 3.1) package program. considering the possible losses in the research and in order to increase the power of the study, it was planned to carry out the research with a total of 60 people, 30 people in the experimental and control groups. while evaluating the findings obtained in the study, spss (statistical package for the social sciences) version 25.0 (ibm corp., armonk, ny, usa) program will be used for statistical analysis.

Eligibility criteria:
inclusion criteria: * volunteer to participate in the research, * literate and open to communication, * knowing the diagnosis, * those aged 45 and over, * receiving short-term or long-term adt treatment, * the patient or his/her relatives have telephone access, exclusion criteria: * having a mental or psychiatric illness that prevents communication, * those with vision-hearing problems

Keywords: prostate cancer androgen deprivation therapy telephone follow-up nursing education
day and night hot flash during menopause

Conditions: Menopause

Summary: we use hot flash diaries to record the change of daily hot flush symptoms, the hot flash related daily interference scale to record how much did hot flush effect daily life, the kupperman menopausal index to evaluate the severity of menopausal symptoms, the pittsburgh sleep quality index to evaluate sleep disorder, wireless temperature monitor to record hot flush and body temperature during sleeping, and classify patients' traditional chinese constitution by using physical classification and judgment self-test table. with these evaluations, we can take apart of different syndromes with different symptom of menopause, thus to confirm the specificity and the severity of menopausal hot flush, and give patients correct treatment.

menopause syndrome or climacteric syndrome is defined as decreasing function of ovarian follicles during menopause. this situation leads to the decreased concentration of estrogen, and causes a series of physical and psychological symptoms, with main symptoms of hot flush, night sweats, dizziness or headache, limbs soreness, insomnia, anxiety and depression. approximately 40-60 % of menopausal women have the problem of menopausal symptoms, these symptoms severely affect the life quality of post-menopausal women. we use hot flash diaries to record the change of daily hot flush symptoms, the hot flash related daily interference scale to record how much did hot flush effect daily life, the kupperman menopausal index to evaluate the severity of menopausal symptoms, the pittsburgh sleep quality index to evaluate sleep disorder, wireless temperature monitor to record hot flush and body temperature during sleeping, and classify patients' traditional chinese constitution by using physical classification and judgment self-test table. with these evaluations, we can take apart of different syndromes with different symptom of menopause, thus to confirm the specificity and the severity of menopausal hot flush, and give patients correct treatment.

Eligibility criteria:
inclusion criteria: * not accept chinese medicine therapy for last 3 months * 40-55 years old female * prolonged menstruation with hot flush, night sweats or insomnia * regular night sleep habit * not take oral contraceptive pill for last 6 months * no smoking, alcohol, drug abused exclusion criteria: * any types of systemic disease * any chronic disease under medicine control * any mental disorder * pregnant women
a retrospective cohort study for main postoperative complications after sars-cov-2 infection

Conditions: Intestines Cancer; Pulmonary Cancer; Liver Cancer; Trauma; Fractures, Bone; Gynecologic Disease

Summary: to explore the relationship between sars-cov-2 infection in different time before operation and postoperative main complications (mortality, main pulmonary and cardiovascular complications) 30 days after operation; to determine the best timing of surgery after sars-cov-2 infection.


Eligibility criteria:
inclusion criteria: * age≥18 years; * patients undergoing any type of surgery in operating room. exclusion criteria: * surgery under local anesthesia (without participation of anesthetist) * surgery outside the operating room, such as gastrointestinal endoscopy, puncture biopsy, etc * patients who cannot determine whether they have had sars cov-2 infection before surgery.
effects of nutritional products on blood glucose in subjects with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: to evaluate average daily blood glucose in subjects with type 2 diabetes following a meal plan including diabetes-specific products compared to average daily blood glucose in subjects following their usual diet.


Eligibility criteria:
inclusion criteria: 1. type 2 diabetes 2. hba1c \>6.5% and \<11.0% 3. male/non-pregnant, non-lactating female, at least 6 months postpartum 4. if female of childbearing potential, practicing method of birth control 5. body mass index \> 18.5 kg/m2 and \< 43.0 kg/m2. 6. weight stable for past two months 7. if on anti-hypertensive, lipid-lowering, thyroid medication or hormone therapy, dosage constant for at least two months exclusion criteria: 1. uses injected medications (e.g., insulin, exenatide) for glucose control. 2. history of diabetic ketoacidosis 3. current infection ; inpatient surgery, or corticosteroid treatment in the last 3 months or antibiotics in the last 3 weeks 4. active malignancy 5. states he/she has had a significant cardiovascular event \< 12 weeks prior to study entry or history of congestive heart failure in the last 12 months. 6. end stage organ failure 7. active metabolic, hepatic, or gastrointestinal disease that may interfere with nutrient absorption, distribution, metabolism, or excretion (such as gastroparesis), excluding diabetes. 8. chronic, contagious, infectious disease, such as active tuberculosis, hepatitis b or c, or hiv. 9. use of herbals, dietary supplements, or medications, other than allowed medications, during past four weeks that could profoundly affect blood glucose. 10. symptomatic in response to blood collection prior to enrollment into this study. 11. clotting or bleeding disorders. 12. non-typical eating pattern 13. is currently using diabetes-specific nutritional product(s)defined as more than one eating occasion per week. 14. engages in strenuous exercise five or more times per week.
risk factors for non-response to hormonal medical therapy in patients with endometriosis

Conditions: Endometriosis

Summary: determine the proportion of patients with endometriosis unresponsive to medical therapy and to compare the clinical and ultrasonographic characteristics of this group of patients (study group) with the clinical and ultrasonographic characteristics of patients responsive to medical therapy (control group).


Eligibility criteria:
inclusion criteria: * age between 18 and 50 years; * patients with endometriosis-related pain symptoms (dyspareunia, dyschezia, dysmenorrhea, chronic pelvic pain, dysuria, periovulatory pain, with at least one of these symptoms presenting numerical pain rating scale intensity \> 5); * indication for administration of oral hormonal medical treatment for endometriosis; * acquisition of informed consent. exclusion criteria: * patients with contraindications to oral hormone treatment * current or previous pelvic infections * history of malignancy or current suspicion of gynecologic malignant lesions * previous pelvic surgery (hysterectomy, salpingectomy, ovarian cyst removal, myomectomy, surgery for endometriosis, bowel resections) * positive history of other causes of chronic pelvic pain * post-menopausal status

Keywords: pelvic pain endometriosis hormone therapy therapeutic non-response risk factors reproduction infertility
artificial intelligence for sepsis prediction in icu

Conditions: Artificial Intelligence; Septic Shock; Intensive Care Unit Psychosis

Summary: the development of sepsis prediction model in line with chinese population, and extended to clinical, assist clinicians for early identification, early intervention, has a good application prospect. this study is a prospective observational study, mainly to evaluate the accuracy of the previously established sepsis prediction model. the occurrence of sepsis was determined by doctors' daily clinical judgment, and the results of the sepsis prediction model were matched and corrected to improve the clinical accuracy and applicability of the sepsis prediction model.

the sepsis prediction model adopted in this study has been completed in the preliminary preparation, which was constructed on 7,000 patients since the establishment of comprehensive icu, and the sepsis 3.0 diagnostic standard was adopted.the sepsis prediction model was built using python platform and xgboost algorithm, which was used to predict the incidence of sepsis in icu patients within 24 hours. the overall accuracy was 82%, and the area under the auroc curve was 0.854. patients who met the inclusion and exclusion criteria were given a daily prediction of sepsis model, and a quantitative checklist was formed based on the test results.there are two kinds of forecast outcomes: low risk and high risk.quantitative checklists are available to attending physicians to improve diagnostic efficiency.the results were kept confidential to the clinician. all patients were diagnosed with sepsis by two senior attending physicians at a fixed time. the diagnosis consisted of two types: yes and no.if two attending physicians have different opinions, the third attending physician will be included for correction diagnosis, and the presence of sepsis will be determined in a 2:1 manner.the attending physicians are independent of each other. when the diagnosis results of the attending physician are input into the system, the prediction results of yesterday's sepsis prediction model are compared and calculated to determine the accuracy of the prediction model

Eligibility criteria:
inclusion criteria: all patients with acute critical illness who are eligible for admission to icu during the study period exclusion criteria: 1. patients under the age of 16; 2. pregnant and parturient women; 3. patients who planned to be admitted to the department for surgery and transferred the next day after evaluation; 4. patients admitted to the department and diagnosed with sepsis; 5. patients with icu stay less than 24 hours;
identifying and characterizing preclinical ms

Conditions: Multiple Sclerosis

Summary: the purpose of this research study is to try and identify risk factors and biologic changes that suggest that someone may go on to develop multiple sclerosis before a person has shown any symptoms of the disease.

the purpose of this study is to try and learn how to identify multiple sclerosis (ms) before it causes any neurologic symptoms. by the time ms causes symptoms, the disease has often been causing damage under the surface for years. because early treatment of ms helps prevent long term disability from the disease, the investigators are hypothesizing that if ms could be detected (and treated) before symptoms start, the disease might be preventable. the investigators believe that people who go on to develop ms have changes in their immune systems long before they have symptoms. some of these changes might be in "hidden" parts of the body, like lymph nodes or fat tissue. the investigators want to study people who have risk factors for ms to try and learn to detect very early signs of disease. study procedures will include: all study participants will undergo a blood draw and an oral swab; they will also complete baseline questionnaires all study participants will be contacted approximately once per year and asked to complete some additional questionnaires all study participants may be asked to donate repeat blood/oral swab specimens or stool specimens over time on an ad hoc basis study participants who agree will undergo additional optional procedures to study the immune system in different parts of the body. the optional procedures include: lumbar punctures (to obtain spinal fluid) tonsil biopsy fat biopsy (to obtain fat cells) lymph node biopsy (to obtain lymph node tissues with immune cells) traditional brain mri low-field (portable) brain mri one in-person visit is required. there will also be annual phone/email contact, which may take up to 30 minutes the required in-person visit will take approximately 1 hour total. anyone who agrees to donate follow up biospecimens, undergo a procedure, or undergo an mri will have additional in-person visits optional visits for donating biospecimens, having a procedure or getting an mri may take longer (up to 3 hours), depending on what is happening during the visit.

Eligibility criteria:
inclusion criteria: * age 18+ * having one or more risk factors for multiple sclerosis, including one or more of the below: * individuals known to have a radiologically isolated syndrome * individuals with a family history of multiple sclerosis (first degree family member) * individuals with personal risk factors, which are known to include smoking, obesity, epstein barr virus infections, vitamin d deficiency, genetic risk score exclusion criteria: * currently pregnant * diagnosis of multiple sclerosis or any ongoing, systemic autoimmune disease * ongoing treatment with immunosuppressive medications
dual-scopic pancreatic necrosectomy (dpn)

Conditions: Pancreatitis; Pancreatitis, Acute Necrotizing; Pancreatic Diseases

Summary: the lpn procedure is performed under general anesthesia. the transperitoneal access to peripancreatic space is via the gastro-colic ligament and greater omentum, effusion and pus is removed by laparoscopic forceps and suction. laparoscopic cholecystectomy (lc) is performed during the lpn procedure on patients with indication. the npn procedure is followed by the standard retroperitoneal approach. after the catheter is exchanged over a guide wire and serially dilated up from 6f to 24f followed by seldinger technique, the access track to the necrotic cavity is established. a nephroscope is inserted into the cavity through the track for debridement. using forceps and suction, the peripancreatic solid necrotic tissue and pus is grasped and removed. a large-bore irrigating drain is left in the cavity, with continuous irrigation by warm normal saline solution at a rate of 100-125 ml/h after surgery.


Eligibility criteria:
inclusion criteria: * all patients ages 18 or above admitted to upmc with a diagnosis of ap based on at least 2 of the following criteria:(i) abdominal pain characteristic of ap (ii) serum amylase and/or lipase ≥ 3 times the upper limit of normal (iii) characteristic findings of ap on abdominal ct scan will be screened for study enrollment. exclusion criteria: * less than 18 years of age * pregnant women * presence of renal dysfunction (cr\>1.5mg/dl) * pre existing heart dysfunction or nyha classification score above iii * coagulation disorder
safety study of abatacept in sweden

Conditions: Rheumatoid Arthritis

Summary: the primary purpose of this study is to assess incidence rates of targeted infections, malignancies and mortality among patients with rheumatoid arthritis who are treated with abatacept.


Eligibility criteria:
inclusion criteria: * resident of sweden exclusion criteria: * none
in vitro and in vivo comparison between intravascular ultrasound (ivus) systems

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to investigate and compare the images obtained from coronary imaging catheters used in the treatment of coronary blockages both in a clinical setting with patients and in models.


Eligibility criteria:
inclusion criteria: * ≥18 years of age * scheduled for a coronary angiogram at the royal adelaide hospital. * women must be non-lactating or not of childbearing potential (1 year post menopausal or surgically sterilized \[total hysterectomy, bilateral tubal ligation, bilateral oophorectomy\]). * target artery must be \>2 mm to accommodate the ivus catheter. * ivus must be clinically indicated or indeterminate angiographic lesion in the artery (40%-70% angiographic stenosis) exclusion criteria: * cardiogenic shock * contraindications to intracoronary nitroglycerin (hypertrophic obstructive cardiomyopathy; cerebral hemorrhage, head trauma; concomitant sildenafil, tadalafil or vardenafil use) * known coronary artery spasm * significant bleeding risk (i.e. previous hemorrhagic stroke, active peptic ulcer disease) * bleeding diathesis * significant renal impairment (patients will be excluded if their calculated creatinine clearance is \< 30 ml/min)