Kornimate/medical-research-clean huggingface dataset:
improving follow-up adherence in a primary eye care setting

Conditions: Eye Diseases

Summary: this study aims to examine the effectiveness of three different ways of helping patients attend their recommended eye care appointments.

the three ways are 1) usual care, which involves a standard reminder letter; 2) automated telephone calls, which utilizes a machine to automatically call patients one month prior to their recommended follow-up date; 3)personalized telephone calls, which utilizes a staff member to personally call patients and offer them the opportunity to schedule at the time of the telephone call.

Eligibility criteria:
inclusion criteria: * age: over 18 years * primary eye care patients who were recommended for a 6-month, 12-month, or 24-month follow-up appointment during september 2013 through november 2013. * access to a telephone exclusion criteria: * does not speak english

Keywords: eye care adherence health care utilization
the norwegian study of chronic fatigue syndrome in adolescents: pathophysiology and intervention trial

Conditions: Chronic Fatigue Syndrome; Myalgic Encephalomyelitis

Summary: the purpose of this study is to * explore the underlying pathophysiology of chronic fatigue syndrome (cfs) in adolescents, particularly focusing on genetics, infections/immunology, endocrinology, autonomic control and cognitions * to assess the effect of clonidine (a drug that attenuates sympathetic nervous activity) in adolescent cfs.


Eligibility criteria:
inclusion criteria: * persisting or constantly relapsing fatigue lasting 3 months or more. * functional disability resulting from fatigue to a degree that prevent normal school attendance exclusion criteria: * another disease process or current demanding life event that might explain the fatigue * another chronic disease (in particular pheochromocytoma, polyneuropathy, renal insufficiency) * permanent use of pharmaceuticals (including hormone drugs) * permanently bed-ridden * positive pregnancy test * evidence of reduced cerebral and/or peripheral circulation due to vessel disease * know hypersensitivity towards clonidine or inert substances (lactose, sakkarose) in capsula * abnormal ecg (in particular bradyarrythmias due to sick sinus syndrome or av-block. isolated ectopic beats do not lead to exclusion) * supine heart rate \< 50 beats/min * supine systolic blood pressure \< 85 mmhg * systolic blood pressure fall upon standing \> 30 mmhg

Keywords: adolescent clonidine autonomic nervous system stress
impact of nrtms therapy on the progress of neurorehabilitation

Conditions: Transcranial Magnetic Stimulation, Repetitive

Summary: low-frequency navigated repetitive transcranial magnetic stimulation (nrtms) of the non-damaged hemisphere to increase cortical excitability of the damaged hemisphere and to reduce the increased neuronal inhibition in patients suffering from new surgery-related paresis after brain tumor resection

postoperative loss of motor function greatly impairs the patients' quality of life and life expectancy of patients with brain tumors is significant limited. hence the reduction of time spent on neurorehabilitation is very important. inclusion of patients that underwent brain tumor resection with a surgery-related paresis of the upper extremity. randomized controlled and double blinded trial - 2/3 nrtms, 1/3 sham. fifteen minutes low-frequency nrtms (1 hz) of the uneffected hemisphere at 7 consecutive days: nrtms group or sham group. thirty minutes physical therapy of the upper extremity in both groups. mri, ntms motor mapping, assessments for motor status of upper extremity including fugl-meyer-assessment (fma), national institution of health stroke scale (nihss), jebsen taylor hand function test (jthft), nine hole peg test (nhpt), and karnofsky performance scale (kps) postoperatively, after the 7th day of intervention and after 3 months.

Eligibility criteria:
inclusion criteria: * new surgery-related paresis of upper extremity after brain tumor resection * written informed consent for participation exclusion criteria: * contraindications for mri * contraindications for nrtms * only biopsy instead of tumor resection * patients without preserved mep response as measured by postoperative ntms motor mapping
mechanisms of myocardial infarction in women with non obstructive coronary artery disease

Conditions: Myocardial Infarction

Summary: the objective of our work to determine the mechanisms of myocardial infarction in women without obstructive coronary artery disease.

cardiovascular disease is the leading cause of death for women. acute coronary syndrome (acs) is usually characterized by a sudden erosion of the endothelial wall or rupture of a plaque.however, women with acs are less likely than men to have either classic symptoms or obstructive coronary artery disease but paradoxically have a worse prognosis. different data from the literature indicate that there may be different pathophysiological mechanisms, afflicting men and women somewhat differently.between 5% and 30% of patients with acs undergoing coronary angiography are found to have non visible or non obstructive coronary disease (nocd). this is 2-3 times more common in women than in men. several pathogenetic mechanism of myocardial infarction (mi) in the absence of obstructive coronary artery disease (ocd) have been postulated, including among others atherosclerosis with plaque disruption that does not lead to luminal occlusion ,endothelial dysfunction, vasospasm , distal microembolization and microvascular dysfunction. however the data are extremely limited.

Eligibility criteria:
inclusion criteria: * women ≥ 18 years old, not pregnant * with acute non st elevation myocardial infarction (admitted within 12 hours from beginning of symptoms) * who are candidates for coronary arteriography during the hospitalization. - exclusion criteria: \*women with troponin elevation caused by other causes -
the micheli functional scale's validity and reliability

Conditions: Low Back Pain

Summary: the purpose of this study is to assess the reliability and validity of the "micheli functional scale" in the turkish context.

the study will include a minimum of 80 individuals who are 16 years old or above, have been engaged in the same sports activity for at least two years, participate in physically demanding activities for at least three days a week, and possess the ability to read and write turkish. before participating in the study, athletes will be required to sign an informed consent form. their demographic information will then be recorded.before conducting the test, we will gather information about the athletes' history of low back pain using the extended nordic musculoskeletal questionnaire. we will also use this questionnaire to identify any other musculoskeletal issues that the person may have.two turkish translators, fluent in english, will independently translate the original micheli functional scale into turkish. they will then discuss their translations and create a common one. the resulting translation will be translated back into english by two native english speakers who are also proficient in turkish. these translations will be reviewed and combined into a single version. a turkish scientist will evaluate the questionnaire for its suitability in the turkish language. the final version will be tested on a small pilot group to determine its comprehensibility. after this, the questionnaire will be administered to the entire study group. to assess the validity of the micheli functional scale, we will use the oswestry functional questionnaire and the ronald morris disability questionnaire. one week after the test, we will repeat these surveys.

Eligibility criteria:
inclusion criteria: * 16 years old and over * having been doing the same sport for at least 2 years, * participating in sports activities or activities that require a high level of effort at least 3 days a week, * able to read and write turkish exclusion criteria: * has a cognitive problem that prevents him from understanding and answering the questions or is taking a drug that may cause them, * having a history of orthopedic or neurological injury or pain at a level that may prevent training or competition during the evaluation, * history of spine/lower and upper extremity surgery, * structural deformities such as scoliosis and kyphosis, * those with trap neuropathy will be excluded from the study.
effectiveness and safety study of etomidate versus midazolam to help place a breathing tube outside of the hospital.

Conditions: Respiratory Failure

Summary: the objective of this study was to compare the utility of etomidate and midazolam in helping patients to relax when there was a need for the placement of a ventilation tube by medics who were transporting patients to a hospital in an ambulance.

study objective: the objective of this study was to compare the utility of etomidate and midazolam for sedative facilitated intubation (sfi), without paralytics, in pre-hospital adult patients. methods: this prospective, double-blind, randomized trial was conducted with two ground pre-hospital advanced life support (als) units. all patients age 18 or over transported by the two participating systems requiring pre-hospital sfi were eligible for participation. the ambulances were stocked with blinded numbered syringes, each containing either 7mg of midazolam or 20mg of etomidate. contact with the medic command physician was not required and no paralytics were used. if sedation was not achieved with the study drug, medics could request additional sedation from a medical command physician; only midazolam or diazepam were available outside of the study.

Eligibility criteria:
inclusion criteria: under the study protocol, all patients age 18 or over transported by the two participating als systems, requiring pre-hospital sedation facilitated intubation, were eligible for participation. exclusion criteria: exclusion criteria were pregnancy and age less than 18.
quantitative sensory testing and analysis of post inguinal hernia surgery pain

Conditions: Hernia

Summary: increasing experience has identified post-herniorraphy chronic pain as an under-recognized and important complication. nerve entrapment and injury are recognized as causes of such pain. operative treatment for selected patients with this condition includes surgical exploration of the affected groin, identification and removal of involved nerves, and removal of meshoma. this procedure has been highly effective in treatment of chronic pain. this study will attempt to subjectively and objectively evaluate the patient's chronic groin pain using quantitative sensory testing (qst) and validated pain scales and questionnaires. quantitative sensory testing is a method used to assess damage to the small and large nerve fibers. it is used to diagnose and assess the severity of nerve damage, and can also help to determine if a neuropathy is responding to treatment. qst uses a computer testing system to measure how nerves react to vibration and changes in temperature. the procedure is non-invasive and the patient will feel minimal to no discomfort during testing. the hypothesis is that any decrease in subjective pain scores would be accompanied by improved qst results.

background: chronic postherniorrhaphy inguinal pain is a complex, major health problem. in the absence of recurrence or meshoma, laparoscopic retroperitoneal triple neurectomy has emerged as an effective surgical treatment of postherniorrhaphy inguinal pain. methods: this prospective pilot study evaluated the neurophysiological and clinical effects of laparoscopic retroperitoneal triple neurectomy. ten consecutive adult with chronic postherniorrhaphy inguinal pain and unilateral predominantly neuropathic inguinodynia underwent three comprehensive quantitative sensory testing assessments (preoperative, immediate postoperative, and late postoperative). pain severity, health-related function, and sleep quality were assessed over the course of a 6-month follow-up period.

Eligibility criteria:
inclusion criteria: * patient with chronic groin pain after inguinal hernia surgery and are candidates for triple neurectomy with mesh removal exclusion criteria: * non-english speaking patients * significant psychiatric or medical disease * bilateral groin pain

Keywords: pain
efficacy and safety study of 5 mg and 10 mg rosuvastatin

Conditions: Dyslipidemia

Summary: the primary objective of the study is to compare the efficacy of rosuvastatin 5 mg once daily with rosuvastatin 10 mg once daily by assessment of the number of patients with hypercholesterolemia reaching the ldl-c target goal of \<100 mg/dl after 12 weeks of therapy.

this study will observe the followings: 1. to compare the effect of 5 mg/10 mg rosuvastatin by assessment of the number of patients reaching ldl-c target goal after 24 weeks of therapy. 2. to compare the effect of 12 weeks therapy with 5 mg/10 mg rosuvastatin on change in ldl-c (compare change from baseline). 3. to investigate the effect of 12 weeks therapy with 10 mg rosuvastatin on change in ldl-c (compare values week 0 vs. week 12). 4. to investigate the safety of rosuvastatin in regards to liver enzyme change, kidney function and muscle toxicity. 5. to compare the effect of 12 weeks therapy with 5 mg/10 mg rosuvastatin on change in tc, hdl-c, tg, ldl-c density and hba1c (compare change from baseline). 6. to investigate the effect of 12 weeks therapy with 10 mg rosuvastatin on change in tc, hdl-c, tg, ldl-c density and hba1c (compare values week 0 vs. week 12). 7. to investigate the effect of 12 weeks therapy on change in microalbuminuria in each treatment group (compare change from baseline). 8. to investigate the effect of 12 weeks therapy on change in bmi (compare change from baseline). the effects of the dose increase and the dose decrease from weeks 12 to 24 will be evaluated as follows: 9. to investigate the change in ldl-c by increasing the dose from 5 mg to 10 mg (compare values week 12 vs. 24). 10. to investigate the change in ldl-c by decreasing the dose from 10 mg to 5 mg (compare values week 12 vs. 24). 11. to investigate the change in tc, hdl-c, tg, ldl-c density and hba1c by increasing the dose from 5 mg to 10 mg (compare values week 12 vs. 24). 12. to investigate the change in tc, hdl-c, tg, ldl-c density and hba1c by decreasing the dose from 10 mg to 5 mg (compare values week 12 vs. 24).

Eligibility criteria:
inclusion criteria: * age 45 - 75 years * ldl - c between 130 mg/dl and 250 mg/dl * tg \< 400 mg/dl * hba1c \< 7% * written informed consent to participate in the trial exclusion criteria: * known hypersensitivity or history of sae with another hmg-coa reductase inhibitor, in particular any history of myopathy * active liver disease/severe hepatic impairment * treatment with cyclosporin or any disallowed drug * patients with unstable angina pectoris

Keywords: dyslipidemia rosuvastatin efficacy safety
investigation of the efficacies of a resveratrol formula on improvement of skin conditions and inflammatory related factors

Conditions: Skin Conditions; Proinflammatory Cytokines

Summary: to assess a resveratrol formula on improvement of skin conditions and inflammatory cytokines in blood


Eligibility criteria:
inclusion criteria: * healthy volunteers aged above 20 years old exclusion criteria: * subject who is not willing to participate in this study. * patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history). * subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * female who is pregnant or nursing or planning to become pregnant during the course of the study. * received facial laser therapy, chemical peeling or uv overexposure in the past 4 weeks. * subjects who have large spots (area \>3 square centimeter) or abnormal acne.
a long-term follow-up study in participants who received ctx001

Conditions: Beta-Thalassemia; Thalassemia; Sickle Cell Disease; Hematologic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Sickle Cell Anemia

Summary: this is a multi-site, open- label rollover study to evaluate the long-term safety and efficacy of ctx001 in pediatric and adult participants who received ctx001 in parent studies 111 (nct03655678) 141 (nct05356195) or 161 (nct05477563) (transfusion-dependent β-thalassemia \[tdt\] studies) or study 121 (nct03745287) or 151 (nct05329649), 161(nct05477563),171 (nct05951205) (severe sickle cell disease \[scd\] studies).


Eligibility criteria:
inclusion criteria: * participants (or his or her legally appointed and authorized representative or guardian) must sign and date informed consent form (icf) and, where applicable, an assent form * participants must have received ctx001 infusion in a parent study exclusion criteria: * there are no exclusion criteria
correlation of high resolution esophageal manometry with symptoms

Conditions: Achalasia; Dysphagia; GERD; Chest Pain; Post Fundoplication

Summary: high resolution manometry is a new technology that utilizes 36 solid state sensors on a thin catheter spaced at 1-cm intervals. one can more effectively measure the pressure of the esophagus. it includes a sophisticated software to display the pressures data as color topography plot using time, length of the esophagus and pressure within the entire esophagus. it is unclear if this technology improvement actually correlates with patient's symptoms.

in a 2007 retrospective study performed using this technology, 400 subjects referred to the motility lab underwent high resolution manometry (hrm) for complaints of dysphasia, gastroesophageal reflux disease, chest pain and miscellaneous complaints. hrm offered greater detail of individual contracting segments of the esophagus, including the duration of contraction and propagation of individual contractions. for example, a new subclass of achalasia was defined by hrm. in this classification, achalasia is divided into types 1, 2 and 3. type 1 corresponds to classic achalasia (complete esophageal motor failure), type 2 is a compression achalasia (simultaneous panesophageal pressurization with aperistalsis), and type 3 is spastic achalasia with aperistalsis (100% spasm). however, it is unclear if this categorization represents a spectrum of disease among patients with achalasia, or it represents distinct subgroups of patients with different symptom presentation and etiology. this study will attempt to correlate the data from hrm to patient's chief compliants, symptom severity, and clinical presentation.

Eligibility criteria:
inclusion criteria: * subjects who are referred to the motility lab to undergoing esophageal hrm for various clinical indications. exclusion criteria: * pregnancy * unable to give consent * less than 18 years old * prisoner

Keywords: high resolution manometry achalasia dysphagia gerd chest pain post fundoplication
a study comparing factor level and inhibitor titer testing results drawn from central venous lines and venipuncture

Conditions: Hemophilia A; Factor VIII Deficiency; Hemophilia; Hemophilia B; Factor IX Deficiency

Summary: the purpose of this research study is to see if factor levels and inhibitor levels in hemophilia a and b subjects are accurate when they are drawn from a central venous line (cvl) instead of from a peripheral stick.

patients with hemophilia a and b sometimes require the placement of a central venous line (cvl). a cvl is a medical device that is placed into a vein that gives easier access to a vein either for a blood draw or to give factor replacement product. patients with hemophilia are usually seen by the hemophilia doctor every year at the annual comprehensive clinic visit. as part of this visit, the doctor usually orders routine blood tests, including the factor level and inhibitor titer.the factor level and inhibitor blood tests are always taken through a "peripheral stick." a peripheral stick means that a small needle is inserted into a vein in order to obtain a blood sample. the cvl is not used for these blood draws. this is because the investigators don't know if the infusion of factor replacement product and heparin (a blood thinning drug used to flush the line after a factor infusion) can cause the blood sample results to be incorrect. the current practice is to take blood through a needle stick in the vein because the investigators can be sure that the results are accurate. when blood draws are taken through a peripheral stick, it can cause children with hemophilia to be very anxious because of the pain involved with a needle stick. also, the needle stick can sometimes cause a bleed, which may require treatment. the purpose of this research study is to see if factor levels and inhibitor levels are accurate when they are drawn from a cvl instead of from a peripheral stick.

Eligibility criteria:
inclusion criteria: * children and adults with hemophilia a or b, ages 1-21 who have cvls for factor infusion and who are prescribed factor prophylaxis for treatment of their bleeding disorder will be included. * subjects will be recruited from active patients at federally funded hemophilia treatment centers (htcs). exclusion criteria: * none
targeted intervention for bipolar smokers

Conditions: Nicotine Dependence; Bipolar Disorder

Summary: the purpose of this research is to develop and test a new type of smoking cessation counseling for individuals with bipolar disorder.

all participants will receive the nicotine patch, an fda-approved smoking cessation medication, in an open-label fashion. in addition to the nicotine patch, participants will be randomized to receive one of the two types of counseling for smoking cessation. participants will be in the research study for approximately 18 weeks. the total number of study visits is 15.

Eligibility criteria:
inclusion criteria: * participants who are motivated to quit smoking * male or female * 18 years of age or older * diagnosed with bipolar disorder according to dsm-iv criteria * stable on medication with no significant changes in the last 3 months before enrollment. * smoking 10 cigarettes/day for the past 90 days exclusion criteria: * healthy volunteers * patients not meeting the criteria for the diagnosis of bipolar disorder according to dsm-iv criteria * not being and being treated with medication for the bipolar disorder

Keywords: smoking tobacco nicotine bipolar