Kornimate/medical-research-clean huggingface dataset:
mapping personality traits to genes

Conditions: Mental Disorder

Summary: previous research involving families, twins, and adoption all support the idea that there is a substantial heritable aspect to personality. the goal of this research study is to determine how genetics influence heritable personality traits. the work will focus on how genetics affect the chemical messengers which brain cells use to communicate with each other (neurotransmitters). the study involves collecting personality data and dna samples from related individuals, primarily male siblings and female siblings, but also including parents. genetic tests performed on these samples will continue to focus on variations in genes, which potentially effect brain neurotransmission. this research has the potential to advance knowledge of genetic influences on human behavior that may be relevant both to normal personality and to psychopathology.

building on family, twin and adoption studies suggesting that substantial aspects of personality are heritable, research under this protocol explores potential genetic influences on normal personality dimensions. we have previously reported associations between variation in neurotransmitter system genes and variation in personality traits, both across and within families, in a sample of the general population. this study involves collecting personality data and dna samples from related individuals, primarily male siblings and female siblings, but also including parents. genetic tests performed on these samples will continue to focus on variations in genes, which potentially affect brain neurotransmission. in some cases, participants are recontacted to specifically investigate whether identified variations in neurotransmitter system genes actually affect neurotransmission. large population samples are needed in this research, particularly since a new epidemiologically standard population sample will be obtained. this research has the potential to advance knowledge of genetic influences on human behavior that may be relevant both to normal personality and to psychopathology.

Eligibility criteria:
personality data and dna samples will be collected from related individuals, primarily pairs of male and pairs of female siblings, but also including parents.

Keywords: behavior genetics normal personality intelligence siblings sixteen personality factor questionnaire neo-personality inventory (revised) x-chromosome
multi-parametric assessment of breast lymphedema

Conditions: Breast Cancer; Breast Lymphedema

Summary: breast lymphedema (swelling due to fluid) is a common complication of breast cancer therapy. unlike lymphedema in the arm, breast lymphedema is not as well-known and has not been studied. at present, no objective and standardized tools exist to evaluate breast lymphedema. the purpose of this study is to investigate the use of ultrasound analysis and bio-impedance to determine if it is possible to measure the extent of the fluid in the breast.

breast lymphedema (swelling due to fluid) is a common complication of breast cancer therapy. limited research has been conducted on the frequency of breast lymphedema with most studies reporting the incidence as ranging from 33 to 48%. women with breast lymphedema describe breast fullness, heaviness and pain associated with breast swelling and changes that impacts how the breast looks (cosmesis) and also impacts their quality of life. at present, no objective and standardized tools exist to evaluate breast lymphedema and correlate it with tissue fluid and fibrosis, and their relationships to local symptoms, cosmesis and quality of life. the goal of the study is to assess and compare photographic, ultrasound and the breast composition in newly diagnosed breast lymphedema, and to assess the use of breast massage to manage breast lymphedema. developing non-invasive image-based methods may enable researchers to map the extent of lymphedema, monitor its progression and evaluate therapies. this may allow for improved quantitate measures to be undertaken to better assess future strategies intended to prevent or improve the management of this treatment complication. patients participating in this study will have ultrasound scans before and after the massage. they will also be asked to complete a questionnaire.

Eligibility criteria:
inclusion criteria: * at least 18 y/o * diagnosis of lymphedema involving the breast * diagnosis of in-situ or invasive breast cancer * female patients following breast conserving therapy and radiotherapy * spoken and written fluency in english; and * able to provide informed consent exclusion criteria: * pacemaker or implanted stimulator or other contraindication to bioimpedance analysis * prior breast surgery on the contra lateral breast * presence of active cellulitis within the breast, trunk or arm and * presence of active cancer
continued use of effective contraception after use of emergency contraception

Conditions: Emergency Contraception; Contraception; Reproductive Health

Summary: women using an emergency contraceptive method must use back up protection for 1-2 weeks depending on method. the copper-iud is the most effective emergency contraceptive method. the investigators wish to explore if women choosing the cooper iud have a higher frequency of use of an effective contraceptive method 3 months and 6 months after the use of an emergency contraceptive method than women who choose to use the emergency contraceptive pill ellaone (ulipristal acetate).


Eligibility criteria:
inclusion criteria: * women over 18 years * eligible for all emergency contraception exclusion criteria: * previous conisation * known stenosis of the cervix * signs of ongoing genital infection * known uterine anomaly * known bleeding disorder
exparel for postoperative pain management in shoulder surgery

Conditions: Fracture of Shoulder and Upper Arm

Summary: the purpose of this study is to compare the effect of liposomal bupivacaine infiltration into the shoulder to continues nerve block with bupivacaine on postoperative pain control and functional outcomes.

liposomal bupivacaine analgesia will provide improved postoperative pain control, reduction in amount of opioid supplementation, decreased complications and faster return to function compared to current standard of care pain management for patients undergoing shoulder arthroplasty and shoulder surgery for proximal humerus fractures.

Eligibility criteria:
inclusion criteria: * patients undergoing shoulder arthroplasty under general anesthesia * patients undergoing open reduction internal fixation (orif) of a proximal humerus fracture under general anesthesia * patients with american society of anesthesiologist (asa) physical status classification of 1-3 * patients meeting criteria for standard of care continuous peripheral nerve block (cpnb) per anesthesia guidelines. * patients agreeing to be available for brief follow up telephone survey post- operatively and being mentally able to respond. * patients available for follow up routine post-operative clinic visits, per standard of care. exclusion criteria: * contraindications to regional anesthesia * significant peripheral neuropathy or neurological disorder affecting the upper extremity * contraindication to a component of multimodal analgesia * pregnancy * opioid tolerance * cognitive or psychiatric condition that might affect patient assessment and/or inability to provide informed consent.
comparison between inhalation and intravenous induction of anaesthesia during interventional mitral valve repair

Conditions: Blood Pressure; Hypotension Drug-Induced

Summary: the induction of anaesthesia is one of the most critical situations for high-risk-patients undergoing interventions surgery. for several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this phase. this retrospective cohort study aims to find out if the choice of the induction agent has a major impact on blood pressure and the use of catecholamines during the induction and the interventional procedure in patients undergoing interventional mitral valve repair.


Eligibility criteria:
inclusion criteria: * patients undergoing elective interventional mitral valve repair * sevoflurane or etomidate have been used for induction of anesthesia exclusion criteria: * pregnancy
pbpk modelling applied to acetaminophen poisoned obese children

Conditions: Poisoning; Obesity

Summary: childhood obesity is increasing globally. changes in body composition and physiology in obesity setting modify pharmacokinetic parameters and might increase the risk in case of poisoning. acetaminophen is a drug often implied in poisoning in children population, especially in adolescent attempting suicide. in practice, clinicians use weight to assess intoxication severity, but depending on the weight chosen (actual weight, lean body weight, ideal weight,..) the severity assessment can change as well as medical care needed. in this context we hypothesize that a pbpk modelling would be helpful to predict toxic dosing in obese population and especially in obese adolescent or children. the primary objective of this study is to collect data related to acetaminophen-poisoned patient with at least one acetaminophen concentration sampling and whose clinical outcome is known in order to refine and validate such a pbpk model.


Eligibility criteria:
inclusion criteria: * all subjects \>/= 10 year old * availability of at least one positive acetaminophen concentration with its associated sampling time * known clinical outcome exclusion criteria: * \< 10 year old * lack of data-

Keywords: pbpk modelling acetaminophen paracetamol pediatrics obesity pharmacokinetics toxicokinetics poisoning
the effects of interventions aiming at optimizing expectations and inducing positive emotions after an acute stressor

Conditions: Healthy Participants

Summary: the purpose of the study is to determine whether a short psychological intervention aiming at optimizing expectations is able to foster positive emotions and whether an intervention inducing positive emotions is able improve participants' expectations. furthermore, the investigators will examine whether both interventions are effective in buffering the stress response after an acute stressor in a healthy sample compared to a control condition.


Eligibility criteria:
inclusion criteria: * fluent in german language exclusion criteria: * chronic disease * mental disease * the evening before the day of the experiment until end of the experiment (the next day): caffeine, alcohol, intensive physical exercise, chewing gum * acute hay fever * current intake of psychotropic medication
personalized medicine using coronary microvascular function measured in patient with percutaneous coronary intervention in angina

Conditions: Coronary Microvascular Disease

Summary: the evidence demonstrating the importance of coronary microcirculation in the management of patients with coronary artery disease is growing. for example, in recent years, a number of studies have demonstrated that the presence of coronary microvascular disease (cmvd) contributes to increased cardiovascular morbidity and mortality independent of the extent and severity of coronary epicardial disease. the index of microcirculatory resistance (imr) is an invasive index proposed for the diagnosis of cmvd. the ability of imr to motivate therapeutic changes in order to subsequently reduce symptoms and improves the quality of life of our patients with stable coronary artery disease (cad) was recently demonstrated. the prognostic value of imr has also been shown in stable cad with pci. thus, after optimal epicardial evaluation and if necessary revascularization according to ffr, imr could represent a tool for personalized medicine adapted to the presence of severe cmvd. the aim of the study is to demonstrate a positive effect of personalized medicine on angina in patients with epicardial coronary network lesion assessment by ffr and with significant cmvd assessed by imr.


Eligibility criteria:
inclusion criteria: * patient over 18 years * symptomatology of angina pectoris * receiving invasive coronary angiography * ffr and microcirculatory resistance index (mri) measurement for at least one epicardial lesion ≥ 50% : * for lesions with ffr ≤ 0.8, revascularization with the xience sierra stent and its evolutions will be performed. optimization of this epicardial revascularization will be evidenced by a post-pci ffr \> 0.8 on all major trunks and if an ffr measurement is not performed, absence of 50% or greater stenosis on two orthogonal views by quantitative coronary angiography \[qca\] at the revascularization site. * for lesions with ffr \> 0.8 revascularization will not be performed * written informed consent exclusion criteria: * a non-coronary indication for coronary angiography, e.g. valve disease, hypertrophic obstructive cardiomyopathy. * severe renal dysfunction (gfr \< 30 ml/min) * contraindications for adenosine: asthma, second or third degree av block without pacemaker or sick sinus syndrome, systolic blood pressure less than 90 mm hg, recent use of dipyridamole or drugs containing dipyridamole, methyl xanthenes such as caffeine aminophylline or theobromine block the effect of adenosine and should be stored at least 12 hours before testing, known hypersensitivity to adenosine. * pregnant women, parturients and breastfeeding mothers * persons of full age who are subject to a legal protection measure or who are unable to express their consent * patient in a period of exclusion from another study * patient under administrative or judicial supervision

Keywords: index of microcirculatory resistance
comparative study between two adjuvant drugs to bupivacaine for post-operative epidural analgesia in abdominal surgeries

Conditions: Epidural Analgesia

Summary: epidural analgesia is associated with early postoperative mobilization and rehabilitation with minimally associated pain and discomfort. analgesic effect of local anesthetics is augmented by addition of adjuvants in epidural anesthesia ensuring satisfactory postoperative period. this study evaluates the effect of dexmedetomidine and fentanyl as additives to bupivacaine for epidural analgesia.

the aim of the study is to evaluate the effect of dexmedetomidin and fentanyl as adjuvants to bupivacaine for postoperative epidural analgesia in abdominal surgeries regarding block characteristics, post-operative analgesia, hemodynamic changes and any anticipated side effects. * type of study: prospective randomized comparative clinical study. * study setting: the operating theatres of ain shams university hospitals * study period: one year * sampling method: random sampling patients randomly allocated by computer generated randomization and using opaque sealed envelopes to one of the three study groups according to the adjuvant drug used in postoperative analgesia. * sample size: total 75 cases divided into 25 cases in each group. kiran et al. (2018) reported a rather large effect size comparing onset to sensory block and time to maximum motor block. in a one-way anova study, sample sizes of 25 cases per group in three groups whose means are to be compared. the total sample of 75 subjects achieves 80% power to detect differences among the means versus the alternative of equal means using an f test with a 0.0500 significance level. the size of the variation in the means is represented by the effect size = 0.4

Eligibility criteria:
inclusion criteria: * asa i or asa ii patients. * age group: 21-70 years old. * bmi ≤40 * duration of procedure ≤ 180 minutes. exclusion criteria: * patients with known neurologic and psychiatric illness will be excluded from the study. * contraindications for epidural anesthesia as patient refusal, bleeding or coagulation test abnormalities, local skin infection at spinal lumbar region, raised intracranial pressure and hypovolemia * spine abnormalities. * systemic disorders like hematological, respiratory, cardiac, renal or hepatic insufficiency. * allergy to any of the drugs used in the study.
randomized trial of parent training for young children with autism

Conditions: Child Development Disorders, Pervasive

Summary: the purpose of this 24 week study is to determine whether a new parent training program is effective in reducing disruptive behaviors in young children with pervasive developmental disorders.

pervasive developmental disorders (pdds) are a group of conditions that includes autistic disorder, asperger's disorder and so called pervasive developmental disorder - not otherwise specified. children with pdd show delays in speech and language and reduced social interaction. some children with pdd also have behavior problems, including defiance of rules, aggression, and tantrums. the purpose of this study is to evaluate a new parent training program designed to decrease these behavior problems and improve daily living skills. following confirmation of eligibility, participants will be randomly assigned to receive either parent training or a psychoeducational program. the parent training program involves specific suggestions about how to deal with behavior problems. the psychoeducational program covers specific issues related to autism and parenting, including an co-occurring medical conditions and treatment options. parents will attend up to 13 one-on-one sessions with a trained therapist over a 24-week period. participation in the study also involves 2 home visits and 6 monthly assessment visits. the purpose of the assessment visits is to evaluate the child's response to treatment. evaluations will also be conducted at 3 and 6 months after completion of the study.

Eligibility criteria:
inclusion criteria: * diagnosis of autistic disorder, pervasive developmental disorder, not otherwise specified, or asperger's disorder * between ages 3 yrs 0 months and 6 yrs 11 months. * no planned changes in the intensity of current treatment(s) * medication free or on stable medication exclusion criteria: * diagnosis of rett's disorder or childhood disintegrative disorder * participation in a structured parent training program in the past 2 years * developmental age \< 18 months (iq \< 35)

Keywords: pervasive developmental disorder autism children behavior therapy aggression tantrums noncompliance
analysis of the reservoir in individuals controlling hiv infection

Conditions: Hiv

Summary: the aim of this study is the gain new insights into hiv latency in hiv controllers through extensive blood an tissue sampling (lymph node, colon biopsies, placenta) from 25 individuals living with hiv and healthy individuals.


Eligibility criteria:
inclusion criteria: * elite controllers: pvl\<50 copies per ml for at least 12 months, treatment naive at the time of inclusion * viral controllers: pvl \ 500/µl for at least two years, treatment naïve at the time of inclusion * long-term non-progressors: cd4\>500/µl, pvl \<10000 copies/ml, for at least 7 years, treatment naïve at the time of inclusion * post treatment controllers: on cart for at least 12 months; pvl \<500 copies/ml for at least 2 years after treatment cessation . * plwh who received bone marrow transplant: people living with hiv who received a bone-marrow transplant for non-hiv related reasons exclusion criteria: * current history of opportunistic infection (aids defining events as defined in category c of the cdc clinical classification), consisting of chronic hiv-1 infection. * evidence of active hbv infection (hepatitis b surface antigen positive or hbv viral load positive in the past and no evidence of subsequent seroconversion (= hbv antigen or viral load negative and positive hbv surface antibody)). * evidence of active hcv infection (hcv antibody positive result within 60 days prior to study entry with positive hcv viral load or, if the hcv antibody result is negative, a positive hcv rna result within 60 days prior to study entry). * current or known history of cardiomyopathy or significant ischemic or cerebrovascular disease. * current history of cancer. * history of hiv-related thrombocytopenia. * any condition, including preexisting psychiatric and psychological disorders, which will in the opinion of the investigator interfere with the trial conduct or safety of the participant. * abnormal results of standard of care laboratory tests: 1. confirmed haemoglobin \<11g/dl for women and \<12 g/dl for men 2. confirmed platelet count \<100 000/µl \* 3. confirmed neutrophil count \<1000/μl 4. confirmed ast and/or alt \>10xuln * active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements. * acute or serious illness, in the opinion of the site investigator, requiring systemic treatment and/or hospitalization within 60 days prior to entry. * the following treatment will be prohibited three months before screening and during the study: 1. immunosuppressive drugs (inclusive corticosteroids) except for drugs used for topical use. 2. immunomodulatory drugs including but not limited to granulocyte-colony stimulating factors, granulocyte-monocyte colony-stimulating factor, interleukin 2, 7 \& 15.

Keywords: hiv latency
exercise during the allogeneic stem cell transplantation

Conditions: Fatigue; Allogeneic Stem Cell Transplantation

Summary: the study will evaluate the effects of a structured endurance exercise program on the physical performance, the mood and the complications of patients with hematological malignancies undergoing a high-dose chemotherapy followed by an allogeneic peripheral blood stem cell transplantation.


Eligibility criteria:
inclusion criteria: * neoplastic malignancy * allogeneic peripheral stem cell transplantation * proficiency in german exclusion criteria: * cardiorespiratory, metabolical, osteoarticular or immunological disorders which can be aggravated by exercise * pathological stress-ecg at admission

Keywords: exercise sport allogeneic blood stem cell transplantation blood stem cell transplantation fatigue cancer physical performance mood complications