Kornimate/medical-research-clean huggingface dataset:
a study of thalidomide plus dexamethasone (thal-dex) versus doxil plusthalidomide plus dexamethasone (doxil -thal-dex) in patients with newly diagnosed multiple myeloma

Conditions: Multiple Myeloma

Summary: the purpose of this study is to determine if thalidomide + dexamethasone or doxil (doxorubicin hcl liposome injection) + thalidomide + dexamethasone is more effective in treating newly diagnosed patients with multiple myeloma. the number of patients whose multiple myeloma disappears for a period of time (complete response) will be studied to make the determination of which treatment is more effective.

this is a multi-center, open-label (all people know the identity of the intervention), randomized (the study medication is assigned by chance) study to compare the safety and effectiveness of thalidomide + dexamethasone versus doxil (doxorubicin hcl liposome injection) + thalidomide + dexamethasone in patients with newly diagnosed multiple myeloma. treatments are administered in 28-day cycles. patients will receive 4 to 12 treatment cycles, depending on the response of their multiple myeloma to the treatment (measured according to the european group for blood and marrow transplant response criteria). patients will have additional tests that include multiple gated acquisition (muga) scans or echocardiograms to assess the patients for potential cardiotoxicity that could be related to treatment with doxil (doxorubicin hcl liposome injection). maximum duration of study participation for each participant will be 48 weeks.

Eligibility criteria:
inclusion criteria: * previously untreated, histologically confirmed multiple myeloma (per international myeloma working group \[imwg\] criteria * eastern cooperative oncology group (ecog) status 0-2 * adequate absolute neutrophil count (anc), platelet count and hemoglobin * adequate serum calcium * enrollment in system for thalidomide education and prescribing safety program (s.t.e.p.s.) exclusion criteria: * no treatment with dexamethasone for multiple myeloma * no peripheral neuropathy of grade 2 or higher * no left ventricular ejection fraction (lvef) of less than 45 percentage * no history of life-threatening thromboembolic events of any kind (ie, myocardial infarction, pulmonary embolism, stroke or others), within 1 year before enrollment in the study * no deep vein thrombosis (dvt) within 1 year of enrollment * no current anticoagulation for dvt

Keywords: multiple myeloma newly diagnosed multiple myeloma thalidomide dexamethasone doxil pegylated liposomal hydrochloride doxorubicin injection
interventions for neck pain in relation to internet usage

Conditions: Internet Addiction

Summary: after the rapid increase in the use of the internet in the world, it has brought some negativities.people with internet addiction describe all the time they spend without internet as worthless and they want to be on the internet with an increasing desire.

under all this information, the exercise program and walking programs that are easily added to people's lives in the study; the effects on stress and sleep levels were investigated by reducing neck pain symptoms in people with internet addiction.

Eligibility criteria:
inclusion criteria: * 20 and 25 years old, have internet addiction * have neck pain complaints for more than three months * low category according to the international physical activity index. exclusion criteria: * participants who had mobility limitations and neurological problems -had spinal surgery, had a traffic accident in the last three months and were injured by whiplash injury mechanism- visual and hearing impairments, * refused to participate in the study.

Keywords: addiction internet
inspiratory muscle training in chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: uncertainty persists regarding the usefulness of incorporating inspiratory muscle training (imt) in pulmonary rehabilitation programs for patients with chronic obstructive pulmonary disease. in this study the investigators investigate whether imt associated with exercise training would be better than exercise training alone, with regard to exercise capacity, inspiratory muscle strength and dyspnea.

study design: a double-blind parallel controlled trial setting: outpatient clinic inclusion criteria: subjects between 40 and 75 years of age referred by a physician to the pulmonary rehabilitation program, with a clinical and spirometric diagnosis of moderate to severe copd according to the global initiative for chronic obstructive lung disease (gold). outcome measurements: inspiratory muscle strength (using maximal inspiratory pressure, mip), exercise capacity (using six-minute walk test) and dyspnea were measured.

Eligibility criteria:
inclusion criteria: * subjects with a clinical and spirometric diagnosis of moderate to severe copd according to the global initiative for chronic obstructive lung disease (gold) * in a stable condition (without exacerbations or infections for at least a month) * had to be former smokers (\> 6 months without smoking) * subjects referred by a physician to the pulmonary rehabilitation program exclusion criteria: * subjects with a known history of asthma, or severe and/or unstable heart disease or any other pathological condition that could impair their physical activities

Keywords: copd inspiratory muscles diaphragm
evaluation of the external validity of the knee sfa score

Conditions: Reliability in the Detection of ACL Injuries in Emergency Departments

Summary: a screening score for acl (anterior cruciate ligament) injuries based on questioning has been developed by the société francophone d'arthroscopie to provide better guidance for post-trauma patients. the score differentiates between 3 groups of patients: mild trauma (score 1 to 4), intermediate trauma (score 5 to 7) and severe trauma (score 8 to 12). the main hypothesis of this study is that it is a reliable score for detecting acl injuries in emergency departments.

injury to the anterior cruciate ligament is a serious and not uncommon event, which can affect the functional future of the knee. the result is instability, leading to meniscal and osteo-cartilaginous damage in the medium and long term. early diagnosis would limit the occurrence of these complications. the average annual incidence of acl rupture in the french population is estimated at around population can be estimated at around 0.03%, or approximately 20,000 cases per year. diagnosis is currently based on clinical examination and dynamic ligament testing. however, these may be difficult to perform in the immediate post-trauma period, leading to a delay in diagnosis. magnetic resonance imaging (mri) is a good diagnostic tool, with a sensitivity of 83-95% and a specificity of 95-100%. however, access to mri is still limited in emergencies, with an average appointment time (all indications combined) of 32.3 days. it is therefore to better target the indications for this examination. the société francophone d'arthroscopie has developed a screening score for acl lesions, based on questioning, to help guide post-trauma patients.

Eligibility criteria:
inclusion criteria: * all patients presenting to adult emergency departments with knee trauma less than 9 days old; * all patients aged between 18 and 55; * all patients without an x-ray fracture (with the exception of indirect signs of injury to the central pivot: segond's fracture and avulsion of the tibial spines); * all patients affiliated to or benefiting from a social security scheme; * all patients who have given their and who have received a study information sheet. exclusion criteria: * trauma requiring immediate surgical treatment (fracture, dislocation); * previous osteoarticular trauma to the knee; * pregnant women; * impossible to carry out an mri (contraindication, refusal, claustrophobia); * impossible to provide follow-up in the same centre; * protected patients: adults under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision.

Keywords: acl (anterior cruciate ligament)
bol-303259-x with timolol 0.5% in subjects with open-angle glaucoma or ocular hypertension

Conditions: Ocular Hypertension; Open Angle Glaucoma

Summary: this clinical investigation is being performed to compare the effect of bol-303259-x dosed once daily (qd) with timolol maleate 0.5% dosed twice daily (bid) in reducing intraocular pressure (iop) measured over a 24-hour period in subjects with open-angle glaucoma (oag) or ocular hypertension (oht).


Eligibility criteria:
inclusion criteria: * subjects must have a diagnosis of oag or oht in 1 or both eyes. * subjects who are treatment-naïve must meet the following iop requirements at visit 1 (screening), and pretreated subjects must meet the following iop requirements at visit 2 (washout): intraocular pressure ≥ 22 mmhg in at least 1 eye and ≤ 36 mmhg in both eyes. exclusion criteria: * subjects who have been exposed to bol-303259-x within 3 months prior to visit 1 (screening). * subjects with a history or presence of chronic generalized systemic disease that the investigator feels might increase the risk to the subject or confound the results of the study. * subjects with an irregular daily sleep schedule. * subjects who are unable to wear sleep monitoring device for 7 days prior to laboratory study. * subjects with an anticipated need to initiate or modify medication (systemic or topical) that is known to affect iop. * subjects for whom concomitant use of medications may interact with the safety or efficacy of a nitric oxide. * subjects with known hypersensitivity or contraindications to latanoprost or any of the ingredients in the study drugs. * subjects who are expected to require treatment with ocular or systemic corticosteroids. * subjects who are in need of any other topical or systemic treatment of oag or oht. * subjects who are unable to discontinue contact lens use during and for 24 hours before the laboratory study. * subjects with a central corneal thickness greater than 600 μm in either eye. * subjects with any condition that prevents reliable applanationtonometry in either eye. * subjects with advanced glaucoma and subjects with a cup/disc ratio greater than 0.8 or a history of split fixation, or a field loss threatening fixation in either eye. * subjects with previous or active corneal disease. * subjects with a history of severe dry eye. * subjects with active optic disc hemorrhage. * subjects with a history of central/branch retinal vein or artery occlusion. * subjects with a history of macular edema. * subjects with very narrow angles and subjects with angle closure, congenital, and secondary glaucoma, and subjects with history of angle closure in either eye. * subjects with a diagnosis of a clinically significant or progressive retinal disease in either eye. * subjects with any intraocular infection or inflammation within 3 months prior to visit 1 (screening). * subjects with a history of ocular laser surgery within the 3 months prior to visit 1 (screening). * subjects with a history of incisional ocular surgery or severe trauma within 3 months prior to visit 1 (screening).
pulmonary complications of hematopoietic stem cell transplantation

Conditions: Lung Disease

Summary: the purpose of this study is to determine risk factors associated with the development of lung disease after hematopoietic stem cell transplantation. depending on the results and findings of this study, it may be possible to predict who is at higher risk of serious complications and ultimately develop therapies to prevent or treat this lung disease.

the development of pulmonary complications after hematopoietic stem cell transplantation is responsible for significant morbidity and mortality. the incidence of pulmonary disease has been reported to be as high as 50% of all patients that undergo transplant. the most common manifestation of early onset lung disease is idiopathic pneumonia syndrome. this can occur in autologous and allogeneic transplants, with an incidence between 5% and 10% and a mortality rate as high as 74%(1). late onset pulmonary disease may be even more frequent and has been reported between 10-24% in recipients of allogeneic hsct(2-4). additionally, a recent study demonstrated 26% of patients develop airflow obstruction after transplant and this was correlated with mortality(5). one quite useful classification system divides late onset pulmonary disease into bronchiolitis obliterans and interstitial pneumonia(4). interstitial pneumonia is a condition characterized by diffuse infiltrates, often with lymphocyte predominance, and associated with restrictive defects on pulmonary function testing. bronchiolitis obliterans is characterized by progressive airflow obstruction and a normal radiograph (except possibly associated air trapping). the incidence of bronchiolitis obliterans after hsct varies widely, but is usually reported to be between 1% and 11%(6-8), although the presence of post hsct obstructive airway disease was reported at 26% in a recent large study(5). late onset pulmonary diseases are often treated with increased immunosuppression, but the prognosis is poor with limited response to therapy(9; 4).

Eligibility criteria:
inclusion criteria: 1. all patients scheduled to undergo hematopoietic stem cell transplantation (hsct) exclusion criteria: 1. patients whose ability to give informed consent is in question. 2. pregnancy.

Keywords: bone marrow transplant hematopoietic stem cell transplantation
comparison of the effectiveness of virtual reality and video assisted exercises in pediatric chronic kidney disease.

Conditions: Pediatric Kidney Disease; Physical Activity; Exercise Addiction

Summary: in this study, we aim to improve respiratory function and balance of decreased muscle strength, decrease fatigue values, improve quality of life, improve inflammation findings and gfr ( glomerular filtration rate) values in pediatric chronic kidney patients with virtual reality exercise applications.

1.group - working group: virtual reality technology (nintendo wii fit plus) exercise group 2.group-control group: home-based video games will be divided into groups that exercise. measurements of functional capacity, muscle strength, quality of life, depression, fatigue and physical activity levels, medical values (pulmonary function test values, inflammation level values, glomerular filtration rate level values) of both groups will be recorded before and after treatment. in the study group treatment protocol; patients will complete 12 sessions of virtual reality exercise application-nintendo wii fit plus 30-minute training sessions with strengthening exercises for the lower extremities and upper extremities, aerobic and balance exercises. they will do 5 minutes warm-up exercises before the session and 5 minutes cool-down exercises as well as breathing exercises at the end of the session and will participate in a 50-minute treatment session in total. in the control group treatment protocol, patients will follow the 30-minute video exercise practices for the lower and upper extremities that are similar to nintendo wii fit exercises for the control group at home two days a week. exercises will complete the 50-minute training session. apart from exercise sessions, patients will record their activities (walking, cycling, swimming...) in daily life forms with their own pedometers. thus, changes in physical activity levels will be monitored.

Eligibility criteria:
inclusion criteria: * 6-18 years of age * to be chronic kidney disease, * to have chronic kidney disease at least 6 months * to have no visual hearing impairment exclusion criteria: * attending another exercise program, * to have severe infection (sepsis, peritonitis) * having anorexia or other growth retardation, * mental retardation, * inadequate communication in turkish, * failure to communicate, * cardiomyopathy, * presence of angina pectoris, * standing and walking obstacle * presence of orthopedic problem * cerebrovascular disease * patients with lower limb amputation and not using orthosis-prosthesis, * patients with metastatic carcinoma will not be included in the study.

Keywords: pediatric chronic kidney disease, virtual reality physical therapy exercise nintendo wii video based exercise
implanted nitinol device (itind) system in chinese males with lower urinary tract symptom secondary to bph

Conditions: Prostate Hyperplasia

Summary: this is a prospective series of consecutive cases of patients undergoing itind for the treatment of male luts.

this is a prospective series of consecutive cases of patients undergoing itind for the treatment of male luts.the procedure was carried out using perioperative antibiotic prophylaxis, according to the local culture and sensitivity profile. patient will be discharged and readmitted 7 days for device removal under local anaesthesia transurethrally. after the device is removed and patients will be monitor for any problem in voiding or haematuria, and then discharged. subjects will be follow-up at 3-, 6, 12- months after treatment.

Eligibility criteria:
inclusion criteria: * men aged between 50 - 80 years * clinically indicated for surgical treatment * prostate volume of 25 to 75 cc exclusion criteria: * patients with active urinary tract infection or in retention of urine * patients with bleeding disorder or on anti-coagulation * patients with bladder pathology including bladder stone and bladder cancer * patients with urethral stricture * patients with neurogenic bladder and/or sphincter abnormalities * patients with previous nonpharmacological prostate treatment, * prostate cancer * fail to give informed consent
impact of glistenings in acrysof intraocular lenses on visual quality

Conditions: Lenses, Intraocular; Glistenings; Visual Quality

Summary: this study will assess the impact of iol glistenings on visual quality and function in patients implanted with a single-piece acrysof intraocular lens (iol) that exhibits glistening formations. the primary objective is to determine if random light scattering (measured by c-quant)correlates with severity of glistenings, other objective measures of visual function (visual acuity, low contrast visual acuity, low contrast visual acuity with glare), and subjective measures of patients' perceptions of their visual quality after cataract surgery (quality of life survey, reports of symptomology and satisfaction).


Eligibility criteria:
inclusion criteria: 1. presence of obvious glistenings by slit lamp exam 2. best spectacle corrected visual acuity of 20/20 or better on the snellen chart at most recent exam exclusion criteria: 1. any central corneal pathology that could have impact on vision other than mild guttata felt unlikely to have any impact on corneal clarity. 2. any documented glaucoma of any kind. 3. any macular pathology except minimal drusen without retinal pigment epithelial pathology felt to be consistent with normal vision. 4. any diabetic retinopathy other than minimal background diabetic retinopathy felt unlikely to affect vision. 5. any other cause of central visual acuity loss including optic nerve, occipital cortex dysfunction or amblyopia. 6. diagnosis of dry eye syndrome, defined as any corneal staining with fluorescein 7. presence of any central posterior capsular opacification. previous yag laser capsulotomy is allowed. 8. any surgical complication having to do with the capsule such as a broken capsule or zonular dialysis or iris trauma or any other complication felt to in any way impact upon the quality of the visual result. 9. any contraindication to pupil dilation

Keywords: glistenings contrast sensitivity visual quality straylight acrysof iol
glycemic excursion minimization (gem) to outshine health disparities

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to see if the gem intervention is acceptable and helpful to black adults with type 2 diabetes. the gem intervention (coaching to reduce carbohydrate intake and increase physical activity after meals, with feedback from a continuous glucose monitor, cgm) might improve blood glucose levels, reduce diabetes distress, and increase empowerment and confidence in managing diabetes.

the purpose of the study is to test the feasibility, acceptability, and initial efficacy of the tailored gem intervention among adult black patients with type 2 diabetes, who are not on insulin or secretagogues.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * capable of making dietary and physical activity changes exclusion criteria: * on insulin or secretagogue * on medications that impede weight loss (e.g., prednisone) * pregnant or planning pregnancy in the next 2 months * no history of moderate to severe hypoglycemia

Keywords: black continuous glucose monitoring physical activity carbohydrate
ephrin b1 regulation in human right appendage

Conditions: Cardiac Diseases

Summary: * background : ephrin-b1 is part of the large eph/ephrin system which is involved in cell-cell comunication. the role of ephrin-b1 has scarcely been studied in adulthood. our team has shown that this protein is expressed in normal heart in mice and humans. in mice with deletion of the gene encoding ephrin-b1, we have shown progressive development of dilated cardiomyopathy characterized by dramatic disorganization of cardiac tissue architecture and decreased heart rate variability. * purpose: ephrin-b1 protein was recently identified in human heart but its putative role remains unknown. in knockout mice, deletion of efn gene is associated with abnormalities in cardiac architecture linked to defects in cell-cell tight junctions. from a functional point of view, mice develop a dilated cardiomyopathy and exhibit decreased heart rate variability in the frequency domain. the purpose of this study is to assess if ephrin-b1 expression is regulated in human heart and if expression level correlates with heart rate variability. * abstract: thirty patients suffering from cardiac disease needing surgery will be included and separated in two groups according to pressure levels in right auricle /and or pulmonary artery. ephrin-b1 expression will be assessed in right appendages at both the transcriptional (quantitative pcr) and protein (western blot) levels. furthermore, the putative relationship between ephrin-b1 expression and heart rate variability (24 hours ecg recordings) will be investigated.

* outcomes * primary: expression level of gene encoding ephrin b1 (quantitative pcr normalized against gapdh gene expression) on human right appendage biopsies * secondary: a/ expression level of ephrin b1 protein on human right appendage using western blot and b/ heart rate variability in both time and spectral domains * study design: exploratory, monocentric , prospective and comparative. two groups of 15 patients each, age and sex matched, with or without elevated pressures in right auricles or pulmonary arteries will be included. * eligibility criteria: * inclusion criteria: patients needing cardiac surgery and who had both right catheterism and 24 hours ecg recording before inclusion; stable medications for at least 4 weeks; age \> 18 years. * exclusion criteria: patient with pace-maker or atrial fibrillation * number of subjects: 30 patients in two groups of 15 patients each. * statistical analysis: qualitative and quantitative variables will be compared using mcnemar test and t test respectively. a p value \< 0.05 will be considered as significant.

Eligibility criteria:
inclusion criteria: * patients needing cardiac surgery and who had both right cardiac catheterism and 24 hours ecg recording before inclusion * stable medications for at least 4 weeks exclusion criteria: * patient with pace-maker or atrial fibrillation

Keywords: cardiomyopathy ephrin-b1 expression cell-cell junctions heart rate variability right appendage