Kornimate/medical-research-clean huggingface dataset:
iron overload and growth velocity in thalassemia and sickle cell anemia

Conditions: Thalassemia; Sickle Cell Disease

Summary: iron overload impaired growth in thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. the issue of iron overload in sickle cell anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients. growth velocity was not systematically studied in patients with iron overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. in sickle cell patients this issue was not studied. the purpose of this study is to assess the growth velocity in a cohort of thalassemia major and intermedia patients and compare the results to another group of sickle cell patients, including sickle cell thalassemia.

growth velocity, endocrine function and iron overload status will be studied in the patients that are in follow up at the pediatric hematology unit, at the ha'emek medical center. patients who were lost from follow up or insufficient data about growth in the past will not included in the study.

Eligibility criteria:
inclusion criteria: * all patients in follow up with available medical charts. exclusion criteria: * patients lost from follow up or without enough data to calculate growth velocity or clinical and laboratory endocrine assessment or missing data about iron status.

Keywords: thalassemia major thalassemia intermedia sickle cell anemia sickle cell thalassemia iron overload growth velocity
combined oral motor stimulation and language on preterm infant feeding

Conditions: Language Delay; Language Development; Feeding; Difficult, Newborn; Mother-Infant Interaction; Maternal Behavior

Summary: this is a randomized controlled trial to study an oromotor stimulation in combination with a reading curriculum in the nicu among preterm infants using oral muscle exercises, language environment analysis (lena) recordings, linguistic feedback, and a language curriculum to improve the neonatal inpatient oral feeding and language outcomes for preterm infants.

this project aims to determine the effects of an oral motor stimulation combined with a reading curriculum vs an oral motor stimulation alone vs controls among preterm infants born 23-30 weeks gestation in the nicu. we hypothesize that the infants receiving an oral motor stimulation in conjunction with a reading curriculum will start oral feeding at an earlier age, have fewer days to full oral feeding, and fewer days in the nicu compared to infants receiving an oral motor stimulation and controls. we hypothesize that the infants receiving an oral motor stimulation in conjunction with a reading curriculum will have increased infant vocalizations, increased conversational turns, increased adult word counts, decreased maternal stress, decreased degree of post-traumatic stress post-discharge, improved receptive and expressive language development at 12 and 24 months, and improved parent reported behavioral outcomes at 24 months.

Eligibility criteria:
inclusion criteria: * 23-30 weeks * english and spanish speaking exclusion criteria: * major congenital anomalies * surgical necrotizing enterocolitis * non-english and non-spanish speaking

Keywords: neonatal feeding neonatal language oromotor stimulation newborn reading parent infant interaction lena
educational intervention for reducing work disability in breast cancer survivors

Conditions: Breast Cancer; Cancer Survivor

Summary: this randomized clinical trial studies an educational intervention for reducing work disability in breast cancer survivors. web sites providing symptom management education may be an effective method to help breast cancer survivors reduce work disability after treatment

primary objectives: i. determine the feasibility and usability of the work ability improvement through symptom management and ergonomic strategies (wise) and empirically evaluate its effect on short-term work ability among breast cancer survivors (bcs). secondary objectives: i. explore individual and workplace factors associated with work ability in bcs. outline: patients are randomized to 1 of 2 treatment arms. arm i: patients receive access to the wise web-based educational intervention to help bcs manage their symptoms, identify ergonomic workplace problems and risks, and implement ergonomic modifications. patients also receive standard of care comprising symptom management therapies and a pamphlet on employment rights. arm ii: patients receive standard of care comprising symptom management therapies and a pamphlet on employment rights. after completion of study treatment, patients are followed up at 3 and 6 months.

Eligibility criteria:
inclusion criteria: * diagnosed with breast cancer * employed at time of cancer diagnosis (defined as paid employment \> 20 hours/week) * within six months of completion of active treatment * working during treatment or intending to return to work following active treatment * computer and internet access exclusion criteria: * patients who do not intend to continue/resume working following treatment * develop distant metastases or progressive disease * prior diagnosis of malignancy at any other site except for in situ carcinomas of the cervix or non-melanomatous skin cancers
impact of volume imaging using diagnostic ultrasound

Conditions: Bone Injuries; Muscle Injuries; Tendon Injuries

Summary: determine if volume imaging can diagnose bone, ligament, muscle injuries.

the investigators are attempting to determine if volume imaging (a new type of ultrasound imaging)can accurately diagnose injuries of the muscle ligaments, tendons and bones when compared to conventional ultrasound imaging.

Eligibility criteria:
inclusion criteria: * age 18 or older * must be scheduled to have a musculoskeletal (bone, ligament, muscle, tendon) ultrasound performed as part of their routine clinical care. exclusion criteria: * unable to lie flat on ultrasound table. * subjects under 18 years of age
a feasibility study on the value of pelvic floor training after pelvic organ prolapse surgery

Conditions: Pelvic Organ Prolapse

Summary: the main objective is to assess the feasibility of a randomized controlled trial that investigates the effects of pelvic floor training on recurrence in pelvic organ prolapse surgeries. this will be achieved by measuring pop-q stage and by a validated questionnaire before surgery and one year after. women having pop surgery at landspitali will be offered to participate if they meet the criteria of the research. participants will be randomized into two groups, interventions and control group that gets standard care at the hospital. the intervention group will meet a physiotherapist 6 weeks post-op for targeted physiotherapy with pelvic floor training, conventional advice and support. over 16 weeks period participants in intervention group will get physiotherapy four times and get two follow up phone calls. pelvic floor activity will be measured with emg and symptoms collected with questionnaire before surgery and year post-op. recurrent surgeries are common problem shortly after the first one. pop symtoms can be bothersome for women and reduce their quality of life. more knowledge is needed to figure out if targeted physiotherapy with pelvic floor training can help reduce recurrency and bothersome symptoms.

a feasibility study to assess the practicality of physiotherapy treatment after pelvic organ prolapse (pop) surgery and the effect on recurrent pop symptoms, pelvic floor activity and general physical fitness. pelvic organ prolapse is a common problem among women and many do need surgery. little is known about recurrence of pop surgeries. pelvic floor muscle training (pfmt) has positive effects on pop symptoms and quality of life. research shows pfmt can reduce stage of the prolapse. before surgery pop-q stage will be measured by urogynocologist. pelvic floor muscle activity will be measured with emg vaginal probes. general physical fitness will be tested with 30s chair-stand and core strenght with prone bride test. an icelandic version of the australian female pelvicfloor questionnaire will be used to assess symptoms and affect on quality of life. participants will be randomized into two groups, intervention and control group. the control group gets standard care at the hospital. the interventional group gets physiotherapy with pfmt, conventional advise and support. during 16 weeks intervention participants get four sessions with specialized physiotherapist and two follow up phone calls. follow up measures will be made at 12 months.

Eligibility criteria:
inclusion criteria: * women having their first pop surgery at lsh * \<80 years old * icelandic speaking exclusion criteria: * women that previously have had incontinence surgery, hysterectomy or previous pop surgery. * dementia, physical disabilities that could affect the research, previous radiotherapy and neurological diseases. * women participating in the research that need to have recurrent pop surgery or incontinence surgery within the year of the surgery.

Keywords: pelvic floor physiotherapy pelvic organ prolapse post op recurrence
amniotic membrane wrapping and tenolysis versus tenolysis alone for treatment of tendon adhesions of the hand/wrist

Conditions: Tendinopathy; Adhesions Nos Postoperative; Scar; Fibrosis

Summary: tendon adhesions of the hand remain a ubiquitous problem facing hand surgeons and hand therapists alike. despite their commonality, no consensus exists as to the best means of preventing adhesions, or the most ideal methods to treat them once they have occurred. the purpose of this study is to compare patient outcomes after standard operative tenolysis performed for adhesions of the hand to outcomes after tenolysis with the use of allograft human amniotic membrane.

patients who are scheduled to undergo operative tenolysis of the flexor and/or extensor tendons of the hand will be recruited. our target enrollment is 40 patients (20 control plus 20 experimental), based on the power analysis detailed in the next paragraph. enrolled patients will be randomized to either standard operative tenolysis, or tenolysis with placement of allowrap. randomization will be performed by computerized random number generator. all surgeries will be performed by one senior fellowship-trained hand surgeon. baseline measurements of total active motion (tam), passive range of motion (prom), and survey scores of the quick disabilities of the arm, shoulder and hand (quickdash) and patient rated wrist evaluation (prwe) will be recorded pre-operatively. in addition, patients' pain level will be assessed using the visual analog scale (vas) both at rest, and during the examination. these same values will be re-evaluated at post-operative follow-up visits at 2 weeks, 1 month, 3 months and 6 months. prom will also be evaluated intra-operatively by the surgeon, and documented.

Eligibility criteria:
inclusion criteria: * all adult patients deemed candidates for operative tenolysis of the hand or wrist * age ≥18 exclusion criteria: * patients younger than 18 years at the time of surgery; * any patient who would not be able or willing to comply with the protocol or perform assessments; * patients with medical conditions that may preclude placement of human biological membrane; * patients who have previously undergone tenolysis on the operative hand; * patients that will have multiple surgeries that are deemed as possible confounders, particularly those requiring an additional incision; * is physically or mentally compromised (i.e. being currently treated for a psychiatric disorder, senile dementia, alzheimer's disease) in a manner that would compromise his or her ability to participate in the clinical study; * is a prisoner; * is a transient.
adrenergic cholinergic enteric measures/mapping

Conditions: Obesity

Summary: patients seen who had autonomic and enteric profiling (adrenergic, cholinergic, enteric measures/mapping=acem_ from 2012-2019 at the university of louisville.

1. patients seen who had autonomic and enteric profiling (adrenergic cholinergic enteric measures/mapping=acem) from 2012-2019 at the u of louisville. 2. results of the physiologic measures of acem had the results recorded. 3. acem is compared to standardized gastric emptying values as the primary measure. 4. acem is also compared to metabolic measures of weight, height and thus bmi as a secondary measure. 5. acem is aloes compared with standardized gastrointestinal symptoms by a traditional patient recorded outcome as another secondary measure. other sites may be added if they have identical irb and/or data sharing agreements with the university of louisville.

Eligibility criteria:
inclusion criteria: * patients with the symptoms suggestive of autonomic and/or enteric disorders. exclusion criteria: * anatomic obstruction of the gi tract * pregnancy * inability of patient or guardian to sign informed consent, if needed * psychiatric disorders precluding assessment and treatment of the patient's gi condition.
stress management in patients with coronary artery disease

Conditions: Stress, Psychological

Summary: introduction: stress can cause hemodynamic and metabolic changes that contribute to endothelial dysfunction and there is a significant association between high stress and cardiovascular events. objective: to evaluate the influence of stress management on endothelial function in patients undergoing percutaneous coronary intervention (pci). methods: randomized, controlled, parallel, intention-to-treat clinical trial. will be considered eligible patients who underwent percutaneous coronary intervention and who have high stress (above average for the brazilian population) in the perceived stress scale (pss-10). patients will be evaluated on pci admission and stress management with cognitive behavioral techniques will be implemented one month after hospital discharge in the intervention group. group sessions will be held between 6-9 people. there will be 4 1-hour meetings for 8 weeks. the primary outcome will be the difference in the variation of brachial artery flow-mediated dilatation (fmd) between the groups and at 3 months of baseline evaluation and at 6-month follow-up after the intervention and the secondary outcome will be the difference in the variation of the velocity of brachial artery. pulse wave evaluated at the same time periods as dmf. outcomes will be evaluated by generalized estimation equations (gee). expected results: in patients undergoing high-stress percutaneous coronary intervention, the use of cognitive behavioral techniques for stress management will improve endothelial function and vascular stiffness.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years; * patients with cad - obstruction of one or more epicardial arteries with at least 70% stenosis and / or left coronary trunk (tbi) with at least 50% - measured by catheterization (cate) and having performed elective pci * high stress: above average score for the brazilian population in the perceived stress scale (pss-10) * signing of the informed consent. exclusion criteria: * age ≥ 80 years * patients with inpatient events (ami, cabg, stroke) * indication of catheterization for valvulopathies or congenital heart disease * severe aortic stenosis / ejection fraction \<30%, cardiomyopathy, severe congestive heart disease * severe diseases with life expectancy \<6 months * cognitive or mental difficulties to understand the instrument * inability to follow up visits

Keywords: stress, psychological; coronary artery disease; percutaneous coronary intervention; endothelium;
an phase iii study of recombinant anti-il-17a humanized monoclonal antibody in chinese participants with pso

Conditions: Plaque Psoriasis Patients

Summary: the purpose of this study is to examin the efficacy and safety of the study drug recombinant anti-il-17a humanized monoclonal antibody in chinese participants with moderate-to-severe plaque psoriasis.


Eligibility criteria:
inclusion criteria: * age ≥18 years old, both male and female. * diagnosis of plaque psoriasis according to the chinese guideline for the diagnosis and treatment of psoriasis (2018). exclusion criteria: * forms of psoriasis other than chronic plaque-type (e.g., pustular, erythrodermic and/or guttate psoriasis) . * other inflammatory diseases. * active autoimmune diseases. * pregnant or lactating women.
vitamin d supplementation and upper respiratory tract infections in adolescent swimmers

Conditions: Upper Respiratory Tract Infections

Summary: background: the medical and economic burden of upper respiratory tract infections (urtis) is extremely high, while prevention and treatment options are limited. therefore, there is a constant need for new methods in order to significantly decrease such morbidity. extensive evidence shows that vitamin d is associated with respiratory health, including in the prevention and treatment of urtis. competitive swimmers have a high prevalence of urtis, and can serve as a model for research in this field. the study hypothesis is that vitamin d supplementation to young swimmers with low vitamin d levels will reduce the frequency, length, and severity of urtis and their accompanying functional impairment, while improving cellular immune function and physical function. methods: after screening 100 competitive adolescent swimmers to obtain \~60 with low serum levels of vitamin d, this study group will be randomized to receive either vitamin d supplementation (2000 iu/d) or placebo, given in a double blinded fashion for three months. participants will fill a daily questionnaire regarding frequency, length and severity of urtis symptoms and functional impairment. blood will be drawn to evaluate changes in vitamin d status (25(oh)d) and immune function among study participants at the beginning of the study and after supplementation. physical function on land and in water will also be assessed. expected results: increase in serum 25(oh)d levels following supplementation will significantly decrease the frequency, length and severity of urti's and their functional impairment, while enhancing the cellular immune system function and physical capacity.


Eligibility criteria:
inclusion criteria: * members of swimming team * training at least 15 hours/week * low vitamin d plasma levels (\<30 ng/ml) * signed consent forms exclusion criteria: * chronic health conditions * taking prescription medications * taking diet supplementations

Keywords: infections immune system vitamin d sport children
the use of antipsychotics in the program of all-inclusive care for the elderly (pace)

Conditions: Behavioral and Psychiatric Symptoms of Dementia

Summary: the aim of this study is to retrospectively evaluate and describe the use of antipsychotics among participants enrolled in the program of all-inclusive care for the elderly (pace), a community-based practice setting.

much national attention has been given to assessing and reducing the use of antipsychotics among nursing home residents, yet comparatively little attention has focused on antipsychotic use among older adults receiving care in community-based settings. the primary objective of this study is to determine the prevalence of antipsychotic use among a nationally representative sample of nursing home-eligible older adults in a community-based practice setting known as program of all-inclusive care for the elderly (pace). the secondary objectives are focused on characterizing antipsychotic use within pace and for these participants. specifically, the investigator's secondary objectives are to describe patterns of other drugs concomitantly used with antipsychotics (e.g., benzodiazepines, opioids) and to identify clinically relevant drug-drug interactions involving antipsychotics.

Eligibility criteria:
inclusion criteria: * participant enrolled in pace contractually receiving pharmacy services from tabula rasa healthcare carekinesis pharmacy (tabula rasa healthcare) during the project time period (january 2017 through december 2017). exclusion criteria: * participant with a diagnosis of bipolar disorder and/or schizophrenia, according to pharmacy records.

Keywords: antipsychotic dementia
a study of ly3164530 in participants with cancer

Conditions: Neoplasms; Neoplasm Metastasis

Summary: the main purpose of this study is to evaluate the safety of a study drug known as ly3164530 in participants with cancer that is advanced and/or has spread to another part(s) of the body.


Eligibility criteria:
inclusion criteria * have advanced or metastatic cancer and be an appropriate candidate for experimental therapy. * have adequate organ function. * prior treatments: * systemic treatments: must have discontinued previous systemic treatments for cancer and recovered from the acute effects of therapy. participants must have discontinued: * cytotoxic therapies or targeted agents that are small molecule inhibitors for 5 half-lives or at least 28 days. * mitomycin-c or nitrosourea therapy for at least 42 days and biologic agents for at least 28 days. * radiation therapy and surgery must be completed 4 weeks prior to therapy, except for limited field radiation therapy, which must be completed 2 weeks before therapy. * if participant is of reproductive potential, must agree to use medically approved contraceptive precautions during the study and for three months following the last dose of study drug. * if the participant is a female of childbearing potential, must have had a negative serum or urine pregnancy test within 14 days of the first dose of study drug and must not be breast feeding. exclusion criteria: * must not have taken an unapproved drug as treatment for any indication within the last 28 days prior to starting study treatment. * must not have an active symptomatic fungal, bacterial or viral infection, including human immunodeficiency virus (hiv) or hepatitis a, b, or c. * must not have a serious preexisting medical conditions or concomitant disorders. * must not have leukemia. * must not have qt interval of \>470 millisecond. * must not have a serious cardiac condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last 3 months.