Kornimate/medical-research-clean huggingface dataset:
a natural history study of corneal abrasions in patients with dystrophic epidermolysis bullosa (deb)

Conditions: Epidermolysis Bullosa Dystrophica; Epidermolysis Bullosa Dystrophica, Recessive; Epidermolysis Bullosa Dystrophica Dominans

Summary: this study is a non-interventional, observational study that will evaluate the natural history of corneal abrasions in patients with dystrophic epidermolysis bullosa (deb).

the objective of this study is to characterize the natural history of corneal abrasions in patients with dystrophic epidermolysis bullosa (deb). patients will be followed via remote weekly symptom diaries and monthly questionnaires to assess corneal abrasion symptoms, frequency, and duration.

Eligibility criteria:
inclusion criteria: 1. the subject or their respective legal guardian must have read, understood, and signed an institutional review board (irb) approved informed consent/assent form and must be able to and willing to follow study procedures and instructions. 2. age 6 months or older at time of informed consent/assent. 3. prior genetic diagnosis of deb due to mutation(s) in the collagen type vii alpha 1 chain (col7a1) gene.

Keywords: dystrophic epidermolysis bullosa deb corneal abrasions
to evaluate the long-term safety of pregabalin in refractory partial epilepsy.

Conditions: Epilepsy, Partial

Summary: to evaluate the long-term safety of pregabalin in refractory partial epilepsy.


Eligibility criteria:
inclusion criteria: * must have met the inclusion criteria for preceding double-blind study. * have received double-blind study medication and wish to receive open-label pregabalin. exclusion criteria: * pregnant or considering becoming pregnant. * receiving any concomitant medication that could alter the effectiveness of their medication response or seizure frequency.
the validity and reliability of the turkish version of the heart failure somatic perception scale

Conditions: Heart Failure

Summary: the aim of this study is to evaluate the validity and reliability of the turkish version of the heart failure somatic perception scale in patients with heart failure.

heart failure is a global health issue that serves as the endpoint for many cardiovascular conditions, particularly coronary heart disease and hypertension. common symptoms of heart failure include fatigue, dyspnea, edema, cough, lack of energy, orthopnea, paroxysmal nocturnal dyspnea, palpitations, and dizziness. these symptoms significantly affect the health-related quality of life of individuals with heart failure, especially in the palliative phase of the disease. additionally, heart failure patients often experience physical limitations, reduced quality of life, and an increased rate of hospital admissions due to symptoms such as breathlessness and fatigue. the heart failure somatic perception scale assesses the presence and severity of 18 common physical signs and symptoms of heart failure (e.g. chest pain), as well as dyspnea and its impact on daily activities through six items. robust and rigorous measures are needed to assess the complexity of heart failure symptoms, and evidence suggests that evaluating a broad range of heart failure symptoms can be beneficial in guiding rehabilitation approaches, clinical decision-making, and survival prediction.

Eligibility criteria:
inclusion criteria: a diagnosis of heart failure. use of optimal pharmacological treatment according to current guidelines for at least 3 months. functional capacity classified as new york heart association (nyha) class i-iv (ambulatory). age 18 or older. ability to cooperate with measurements. exclusion criteria: known cognitive impairment. having undergone acute coronary syndrome, percutaneous coronary intervention, or heart surgery within the past three months.
effectiveness of a school-based hand sanitizer program on reducing asthma exacerbations

Conditions: Asthma

Summary: asthma is a common, serious illness among children in the united states. improving hand cleanliness and hygiene may prevent the spread of viruses that can cause asthma exacerbations. this study will evaluate the effectiveness of a school-based hand sanitizer program at reducing the frequency of exacerbations in children with asthma.

in the united states, almost 9 million children have been diagnosed with asthma. it is a leading cause of hospitalizations and school absenteeism among children. asthma symptoms are often seasonal, with the greatest number of exacerbations occurring in autumn and the fewest in mid-summer. elementary school children are the most vulnerable to these seasonal changes, and many children experience an increase in exacerbations at the beginning of the school year. recent research suggests that this seasonal peak in exacerbations is primarily caused by viral respiratory tract infections that are spread among children in school. regular handwashing has been widely recognized as the most effective way to stop the spread of viruses and infectious illnesses. however, effective handwashing methods among school-age children can be inconsistent. time constraints, a frequent lack of soap and towels, inconveniently located sinks, and water-saving faucets are all barriers to thorough handwashing. improving hand hygiene through the use of antimicrobial rinse-free hand sanitizers in school classrooms may be a simple and effective way to reduce the risk of transmitting viruses that can cause asthma exacerbations. the purpose of this study is to evaluate the effectiveness of a school-based hand sanitizer program at decreasing exacerbations in children with asthma. this study will enroll children with asthma who are attending one of the 32 participating schools. each school will be randomly assigned to either use their usual hand hygiene practices in year 1, followed by a two-step hand hygiene program including hand washing plus hand sanitizer in year 2, or vice versa. each participant will log in to an internet-based data collection system on a daily basis to document their asthma symptoms and peak flow meter readings. teachers will also log in daily to verify participants' data and to document participants' absences and the reason for the absence. quick relief medication use will be recorded and measured through the use of a doser device on participants' inhalers.

Eligibility criteria:
inclusion criteria: * diagnosed with asthma * enrolled in a participating elementary school

Keywords: hand sanitizer respiratory infection
telangiectatic palmoplantar keratoderma in systemic and subacute lupus erythematosus

Conditions: Systemic Lupus Erythematosus; Lichen Planus

Summary: palmoplantar keratoderma (ppk) associated to livid telangiectatic erythema during systemic lupus erythematosus (sle) and subacute cutaneous lupus erythematosus (scle) is a rare phenomenon seldom reported in literature. the investigators hypothesize that clinic-immunologic assessment and detailed investigation of cutaneous biopsy specimen of ppk and erythema of patients suffering from sle and scle could lead to determine more precisely nosological settings of this injury. report the different therapeutics with efficacy assessment could be helpful to highlight useful treatment for these patients.

context: palmoplantar keratoderma (ppk) associated to livid telangiectatic erythema during systemic lupus erythematosus (sle) is a rare phenomenon seldom reported in literature. to our knowledge no case has been described in subacute cutaneous lupus erythematosus (scle) so far. pathogeny and etiologic origin are not clear: it could be no-specific cutaneous manifestation of sle, verrucous chilblain lupus, lichen planus, discoid lupus erythematosus lesions, overlap syndrome or coexistence of both diseases. objective: 1. determine clinical immunological and histopathological features of patients with ppk and livid telangiectatic erythema-associated suffering from sle and scle 2. describe the different therapeutics used and efficacy assessment methods: multicentric retrospective descriptive study reporting 14 patients with sle or scle suffering from an acral livid erythematosus keratoderma, with clinical data regarding lupus erythematosus and acral keratoderma, immunological blood samples findings and histopathological results of keratoderma and livid erythema biopsies with direct immunofluorescence if performed. the treatments set down in order to heal are noted followed by efficacy assessment: total failure, partial remission, complete remission.

Eligibility criteria:
inclusion criteria: * \> 18 years old * suffering from sle or scle according to 2019 acr/eular criteria * with palmar and or plantar keratoderma with livid telangiectatic erythema exclusion criteria: * \< 18 years old * suffering from lupus lesions without sle or scle criteria * without palmar and or plantar keratoderma with livid telangiectatic erythema

Keywords: palmoplantar keratoderma with livid telangiectatic erythema systemic lupus subacute lupus erythematosus
application of amide proton transfer-weighted imaging in predicting pathological complete response after neoadjuvant therapy of rectal cancer

Conditions: Rectal Cancer

Summary: the goal of this observational study is to learn about the amide proton transfer-weighted imaging for rectal cancer response assessment after neoadjuvant therapy. the main question it aims to answer is: • does amide proton transfer-weighted imaging predict the cancer response before surgery? participants will underwent amide proton transfer-weighted imaging as part of their regular mri examination.


Eligibility criteria:
inclusion criteria: * locally advanced rectal cancer(ct3-4, or cn+), resectable, histologically confirmed rectal adenocarcinoma * received neoadjuvant therapy before surgery * complete radical resection of rectal cancer and postoperative pathological examination * informed consent and signed the informed consent form exclusion criteria: * poor image quality, such as severe artifacts * complicated with intestinal obstruction, intestinal perforation and other cases requiring surgical treatment * the interval between preoperative mri and surgery was more than 2 weeks * prior treatment for rectal cancer * history of other malignant tumors * patients who cannot undergo mri examination due to contraindications or relative contraindications * patients were lost to follow-up or voluntarily withdrew from the study due to adverse reactions or other reasons
glucose containing and glucose free hemodialysate in type 2 diabetic patients

Conditions: End-Stage Kidney Disease; Type 2 Diabetes Mellitus

Summary: the purpose of this study is to investigate differences in glycemia * during the whole hemodialysis day and the whole freeday * during hemodialysis, during the evening and the night after hemodialysis and at the same time intervals during the freeday in an unselected type 2 diabetic patient group using both glucose-containing and glucose-free dialysate.


Eligibility criteria:
inclusion criteria: * type 2 diabetic patient * undergoing stable intermittent thrice weekly hemodialysis for at least one month exclusion criteria: * none

Keywords: hemodialysis continuous glucose monitoring hypoglycemia hyperglycemia
endoscopic preperitoneal parastomal hernia repair (epauli repair)

Conditions: Parastomal Hernia

Summary: observational study on laparoscopic and robotic extraperitoneal mesh repair of parastomal hernia, employing tar.

endoscopic trans-abdominal preperitoneal plasty (tapp) for parastomal hernia employing transversus abdominis release component separation (tar) and reinforcement with mesh after the sugarbaker principle, but placing mesh extraabdominally, anteriorly to the transversalis fascia. laparoscopic and robotic procedures. repair of concomitant midline hernia with endoscopic enhanced-view rives-stoppa technique.

Eligibility criteria:
inclusion criteria: * parastomal hernia with need of repair exclusion criteria: * \< 18 years

Keywords: hernia parastomal robotic laparoscopic transversus abdominis release repair incisional
sc-002 in small cell lung cancer and large cell neuroendocrine carcinoma

Conditions: Small Cell Lung Cancer

Summary: this is a phase 1a/1b study of sc-002 in patients with relapsed small cell lung cancer (sclc) or large cell neuroendocrine carcinoma (lcnec). sc-002 is an antibody-drug conjugate (adc) comprised of a monoclonal antibody linked to a potent chemotherapy. the purpose of this study is to assess the safety and tolerability of sc-002 at different dose levels, to determine the highest dose of sc-002 that can be given to patients with sclc or lcnec, to evaluate the side effects of sc-002, and to assess the anti-cancer activity of sc-002.

part 1a is a dose escalation study in patients with small cell lung cancer or large cell neuroendocrine carcinoma with cytologically confirmed, limited or extensive sclc or lcnec that have relapsed or refractory limited or extensive disease following no more than 2 prior chemotherapy regimens. part 1b is an expansion study where patients will be enrolled and treated in order to further characterize safety and preliminary efficacy in patients with sclc or lcnec and further characterize pk, immunogenicity and target expression and possible relationship to clinical outcome.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed sclc (either limited or extensive disease) or lcnec, that has relapsed from the most current treatment or was refractory to treatment * evidence of progressive disease during or following no more than 2 prior chemotherapy regimens * measurable disease as defined by recist * ecog performance status of 0 or 1 * adequate hematological and organ function as confirmed by laboratory values * treatment with anticancer/investigational drugs, therapy ≤ 4 weeks prior to first dose of sc-002 exclusion criteria: * active central nervous system metastases * uncontrolled cardiac disease * positive serology for hepatitis b or hepatitis c or known hiv infection * presence of any condition that may increase the risks associated with study participation and interfere with the interpretation of study results

Keywords: small cell lung cancer
a family-based diabetes intervention for hispanic adults in an emerging community

Conditions: Diabetes Mellitus, Type 2

Summary: the aim of this study was to compare the efficacy of an intervention and an attention control group in producing changes in diabetes self-management, glycemic control (hba1c) and health related quality of life in hispanics with type 2 diabetes. hypothesis: the experimental group who receive an 8 week intervention program would show significantly greater improvements than an attention control group at 1 and 6 months after the intervention in: behavioral influences of diabetes knowledge, diabetes self-efficacy, and family support, outcomes of self-reported management of diabetes (physical activity, diet, medications, and glucose monitoring), hba1c levels, and psychological outcomes of health-related quality of life.

a total of 186 participants and their family members were recruited, 103 in the experimental group and 83 in the attention control group. an intervention consisted of eight weekly interactive modules, for a total of 12 hours, and based on modules from national standards for diabetes self-management education, and the national diabetes education program. data were collected at baseline, immediately post-intervention, and at 3 and 6 month follow-up visits.

Eligibility criteria:
inclusion criteria for participants: 1. community-dwelling 2. self-identification as hispanic 3. age 18 years or older 4. self-identification as having a medical diagnosis of type 2 diabetes 5. an adult family member willing to participate in the study. 6. must be able to speak either english or spanish inclusion criteria for family members/relatives are: 1. family member is over 18 2. reside in the same household as the participant with diabetes 3. must be able to speak either english or spanish exclusion criteria: we will exclude hispanic adults and family members who are: 1. diagnosed with type 1 diabetes 2. report prior (within the past year) or current participation in other diabetes self-management intervention programs 3. cognitively impaired (not oriented to time, place, or person, or with known dementia) 4. pregnant at the time of t1 (baseline) data collection

Keywords: type 2 diabetes hispanic adults diabetes self-management family-based intervention
effects of acupuncture-assisted rehabilitation protocol for achilles tendon rupture

Conditions: Achilles Tendon Rupture

Summary: this prospective study is to compare the rehabilitation effect between the patients with achilles tendon rupture using traditional rehabilitation protocol and acupuncture-assisted rehabilitation protocol. the main question it aims to answer is whether acupuncture is an effective rehabilitation treatment. the patients are divided into the traditional rehabilitation group and acupuncture assisted rehabilitation group. the time of return to light sports activity and other indicators of the two groups will be compared.

this prospective randomized controlled clinical study is designed to compare the treatment outcomes of different rehabilitation protocols by dividing the patients into two groups-based on the traditional rehabilitation protocol and acupuncture-assisted rehabilitation protocol. see the text for detailed inclusion and exclusion criteria. patients that meet all the inclusion criteria but do not meet any exclusion criteria, and who have signed the informed consent will be recruited, and each patient will be assigned a unique patient identification number, which will be used throughout the study identify the patient. all patients be treated surgically with the same suture technique. for acupuncture-assisted rehabilitation group, patients will receive additional acupuncture treatment. investigators will collect indicators from multiple dimensions such as ankle function and pain level to compare the efficacy of the two groups. the achilles tendon , despite being the largest and strongest tendon, is often prone to ruptures. the latest evidence48 has demonstrated that at centers using functional rehabilitation, nonoperative treatment results in similar rerupture rates but significantly lower complica- tion rates than surgical treatment. so we expect this trial to point out better rehabilitation. in traditional chinese acupuncture, nearly 400 acupoints on the body surface are interrelated to various functions. acupuncture has also been widely studied for the treatment of motor system diseases. however, trials on rehabilitation of achilles tendon rupture are still lacking.

Eligibility criteria:
inclusion criteria: * acute closed single-legged complete achilles tendon rupture * age of 18 to 60 years. exclusion criteria: * patients with prior achilles tendon rupture or other situations that affected their lower limb functions or tendon healing (e.g., autoimmune disease, diabetes mellitus, systemic corticosteroid treatment). * an inability to complete our suture technique (e.g., the distance from the rupture site to the achilles tendon insertion was less than 3.5 cm) . * those without rehabilitation or follow-up outcomes.

Keywords: rehabilitation acupuncture
prevalence of hepatitis c virus infection among rheumatological patients

Conditions: Hepatitis C

Summary: egypt has the highest prevalence of hepatitis c virus (hcv) in the world. in 2015, the prevalence of hcv rna was found to be 7.0%.(1) the prevalence of hcv was studied in rheumatoid arthritis in few studies(2,3), but to our knowledge, no previous work studied it in other rheumatologic diseases.

egypt has the highest prevalence of hepatitis c virus (hcv) in the world. in 2015, the prevalence of hcv rna was found to be 7.0%.(1) the prevalence of hcv was studied in rheumatoid arthritis in few studies(2,3), but to our knowledge, no previous work studied it in other rheumatologic diseases. this study aims at detecting the prevalence of subclinical hcv infection in different rheumatologic disease groups in egypt. consecutive patients with different rheumatologic diseases from seven- geographically different- rheumatology departments were prospectively studied. none of the patients was known to have previous hcv infection. patients' serum samples were screened for the presence of anti-hcv antibodies. patients with positive serology were further evaluated for the presence of hcv ribonucleic acid by reverse transcriptase polymerase chain reaction (rt-pcr)

Eligibility criteria:
inclusion criteria: * consecutive patients with different rheumatologic diseases from seven- geographically different- rheumatology departments were prospectively studied. none of the patients was known to have previous hcv infection exclusion criteria: * pregnancy and end organ failure
humax-cd20 in chronic lymphocytic leukemia

Conditions: Chronic Lymphocytic Leukemia

Summary: the purpose of this trial is to determine the safety and efficacy of humax-cd20 as a treatment for chronic lymphocytic leukemia.


Eligibility criteria:
inclusion criteria: * chronic lymphocytic leukemia * circulating lymphocytes above a specific level * circulating lymphocytes showing certain markers exclusion criteria: * previous treatment with rituximab or alemtuzumab within 6 months prior to enrollment in study. * previous stem cell transplantation. * received any of the following treatments within 4 weeks prior to entering this trial: a) anti-cancer therapy, b) glucocorticoids unless less than 10 mg per day, c) radiotherapy. * hiv positivity. * hepatitis b or hepatitis c. * other cancerous diseases, except certain skin cancers and cervix cancer. * certain serious medical conditions, including kidney or liver disease, some psychiatric illnesses, and stomach, heart, hormonal, nerve or blood diseases. * participation in another trial with a different new drug 4 weeks prior to enrollment in study. * current participation in any other clinical study. * pregnant or breast-feeding women. * women of childbearing age who are unable or unwilling to use adequate contraception.

Keywords: chronic lymphocytic leukemia b-cell lymphoma