Kornimate/medical-research-clean huggingface dataset:
emotional intelligence skills health leaders need during covid-19

Conditions: Emotional Intelligence; Leadership; Health Personnel Attitude; Covid-19

Summary: problem the study will address the problem that no studies have established the emotional intelligence (ei) skills required by leaders and managers to engage frontline healthcare professionals in crisis situation like covid19 in kenya purpose the purpose of the qualitative exploratory study is to identify the ei skills leaders and managers need to engage frontline healthcare professionals in crisis. the research question is: what are the ei skills leaders and managers need to engage frontline healthcare professionals (fhp) during crisis situations such as the covid19 pandemic?

hypothesis the study hypothesis that leaders and managers with appropriate emotional intelligence skills will engage frontline healthcare professionals in crisis situations resulting in desired outcomes data collection the data collection will start with a primer survey on surveymonkey.com, behavioral and cognitive assessments through the predictive index, emotional intelligence competence assessments through emco4.com, followed by semi-structured face to face or virtual interviews with the participants. the survey data, assessments and the transcribed semi-structured interviews will be depersonalized and made available for subsequent researchers. the videos if any will be destroyed three years after transcription. participants the 20 participants will be selected from the population. the study population is the number of experienced frontline healthcare professionals working in busia county of kenya. the county department of health will help in recruiting participants from doctors, nurses, and other frontline healthcare professionals. data analysis the data will be analyzed using discovertext.com cloud-based platform applying two rounds of coding: first in vivo coding will be applied then prior codes will be enforced. the vivo codes will be in the participant's word and voice. eight priori codes will be adopted from ei literature. societal benefits society needs healthcare professionals to deal with crisis situations that place them in imperilment. the leaders have constraints of resources, time and advanced knowledge. this study seeks to seek out ei skills that will enable leaders to engage healthcare professionals while recognizing the humanity in them.

Eligibility criteria:
inclusion criteria: experience frontline healthcare professionals working in busia county of kenya exclusion criteria: * none healthcare professionals * healthcare professionals not working in busia county
imgts for patients with behavioral and psychological symptoms of dementia (phase 2)

Conditions: Dementia Alzheimers

Summary: the proposed research project aims to answer the question "are immersive technology systems effective in the management and treatment of patients with bpsd?". this project is composed of three phases and the current study is the second phase. the phase 2 trial aims to create an immersive technology system for managing the behavioral and psychological symptoms of dementia and determine its clinical effectiveness, safety, usability, and acceptability among patients with mild to moderate alzheimer's disease.


Eligibility criteria:
inclusion criteria: * aged 60 years old or older * diagnosed with mild to moderate alzheimer's dementia according to the national institute of neurological and communicative disorders and stroke and the alzheimer's disease and related disorders association (nincds-adrda) criteria * montreal cognitive assessment-philippines (moca-p) score of 10-20 inclusive * neuropsychiatric inventory (npi-12) score 1-50 inclusive * reisberg scale stage 4-5 inclusive * stable dose of antidepressants for the past 6 weeks * stable dose of antipsychotics for the past 4 weeks * able to walk unassisted or with minimal assistance, with or without assistive device * no other explanation for condition based on reasonable clinical diagnostics exclusion criteria: * have mild cognitive impairment (no dementia) * have moca-p score less than 10 or more than 20 * other non-amnestic dementia syndromes * have receptive aphasia * have significant visual or hearing impairment * have an active psychiatric disorder prior to alzheimer dementia diagnosis * had previous episodes of seizures, diagnosis of epilepsy, or intake of antiepileptic or seizure medications * have quadriplegia or paralysis of the dominant hand * have a history of motion sickness * experience claustrophobia * have a diagnosis of a terminal illness or a life expectancy of less than one year
chronic versus intermittent deep brain stimulation for essential tremor

Conditions: Essential Tremor

Summary: the proposed study is a randomized, single blind trial of intermittent versus continuous stimulation among essential tremor (et) patients with a chronic history of continuous stimulation.

the proposed study is a randomized, single blind trial of intermittent versus continuous stimulation among essential tremor (et) patients with a chronic history of continuous stimulation. the trial is 10 weeks in length with clinical evaluations (about 60 minutes) performed on weeks 1, 2, 6, and 10, and phone interviews (about 5 minutes) on weeks 3, 4, 5, 7, 8, and 9. the study includes outcome measures of tremor, stimulation-induced side effects, sleep quality, and voltage threshold for optimal tremor control and sustained side-effects.

Eligibility criteria:
inclusion criteria: * individuals with essential tremor who are at least 6 months status-post thalamic stimulator placement * maintained a consistent chronic or intermittent stimulation schedule for at least 4 consecutive weeks prior to study enrollment * no changes in stimulation parameters for at least 2 consecutive months prior to study enrollment exclusion criteria: * patients with clinically significant dementia (i.e., a score less than 24 out of 30 on the mini mental status exam14) * women who are not post-menopausal * patients with other significant neurological or psychiatric disease other than essential tremor * patients treated with pallidotomy or thalamotomy * patients with significant psychiatric disturbance as determined by diagnostic and statistical manual-iv criteria which would make informed consent/cooperation problematic
lateral sagittal vs costoclavicular brachial plexus block in children

Conditions: Hand Injuries and Disorders; Forearm Injuries

Summary: costoclavicular approach has lots of advantages compared to the lateral sagittal approach for infraclavicular brachial plexus block. although the efficacy of this block has been demonstrated in adults, there are no randomized controlled trials in the literature on the application of pediatric patients. our aim was to compare the ultrasound-guided infraclavicular and costoclavicular approach in pediatric patients.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologist's physiologic state i-ii patients * patients who will undergo hand or forearm surgery exclusion criteria: * infection in the area to be injected * coagulopathy, * previously known neurological damage
measurement of refractive se following implantation of ls313 mf30 iol

Conditions: Refractive Errors

Summary: this study determines the most precise method for measuring post-operative refraction following implantation of the asymmetric multifocal ls-313 mf30 comparing the results of refraction of the different autorefractor keratometers with the subjective measurements for distance and near.

this is a post market study without invasive interventions. the patients have been treated with cataract surgery and miol implantation at least 3 months ago. they will be invited for only one follow up visit to measure the postoperative refraction with different autorefractor-keratometers, a manual refractometer, the test device "itrace" and with determination of the subjective refraction for distance and near with the appropriate corrections at the department of ophthalmology in neubrandenburg, germany.

Eligibility criteria:
inclusion criteria: patients after cataract surgery with implantation of the mics-iol ls-313 mf30 postoperative clear cornea willing to participate in the study exclusion criteria: significant corneal opacities, history of keratoplasty, anterior capsule phimosis, posterior capsular opacification if patients refuse nd:yag laser treatment of the secondary cataract

Keywords: multifocal intraocular lens postoperative measurements of refraction
safety, efficacy, tolerability and pharmacokinetics of agn-223575 ophthalmic suspension in patients with dry eye disease

Conditions: Dry Eye Syndromes

Summary: this study will evaluate the safety, efficacy, tolerability, and systemic pharmacokinetics of 3 different doses of topical ophthalmic agn-223575 suspension compared to agn-223575 vehicle in patients with dry eye disease.


Eligibility criteria:
inclusion criteria: * signs and symptoms of dry eye disease * has used restasis and/or artificial tears in both eyes twice a day for at least 60 days. exclusion criteria: * history of glaucoma, or ocular hypertension * diagnosis of ocular infection * use of contact lenses in the past 14 days or expected use during the study * use of any topical ophthalmic medications in the past 30 days * use of corticosteroids in the past 30 days.
mixed methods implementation evaluation of an integrated depression and microfinance program for women in vietnam

Conditions: Depression

Summary: this is an implementation project to develop a model to support implementation of life-dm, an evidence-based practice (ebp) program that integrates depression management with microfinance services to address both poverty and depression among low-income women in vietnam. this evaluation is a mixed methods study that will 1) describe the development of community-partnered implementation process, 2) study the effectiveness of the training and implementation support plan on provider and patient outcomes, and 3) identify factors that impact implementation success.

livelihood integration for effective depression management (life-dm) aims to address the dual challenges of poverty and depression faced by women in vietnam by integrating evidence-based treatment for depression management and microfinance services. with funding from nimh, the investigators established initial evidence for the effectiveness of life-dm in reducing depression and improving functioning, social support, self-efficacy, and income at six months. these treatment effects were maintained at twelve months, suggesting that the life-dm program may be an effective strategy to break the cycle of depression and poverty in low-income women. for the grand challenges of canada (gcc) transition to scale grant, the investigators developed a model to scale up the program in the public health and social system across two provinces, danang and thua thien hue through 1) the training of local trainers from the psychiatric hospital to support local implementation, 2) development of a supervision model, and 3) use of a learning collaborative. to evaluate the success of the model, the investigators will conduct a mixed methods implementation study that will assess implementation and patient outcomes according to the re-aim framework, as well as identify barriers and facilitators to implementation.

Eligibility criteria:
inclusion criteria: * depression - based on patient health questionnaire total score = \> 9 * low-income * female * ages 18 - 60 exclusion criteria: * psychosis risk * mania risk * substance abuse risk * high suicide risk * physical disabilities * significant cognitive impairments

Keywords: depression poverty
seroepidemiological study of sars-cov-2 (covid-19) infection in population subgroups in the state of são paulo

Conditions: COVID; SARS-CoV 2

Summary: seroepidemiological study of sars-cov-2 infection in population subgroups in the state of são paulo

this is a cross-sectional study to estimate the prevalence of antibodies against sars-cov-2 is different population subgroups in the state of são paulo

Eligibility criteria:
inclusion criteria: * all potential volunteers invited to participate in the study. exclusion criteria: * all potential eligible participants, but who do not show interest in participating in the study.
vagus nerve stimulation in treatment of postural orthostatic tachycardia syndrome

Conditions: Postural Orthostatic Tachycardia Syndrome

Summary: postural orthostatic tachycardia (pots) is characterized by abnormalities in the autonomic nervous system in the body. the autonomic nervous system controls and regulates body functions such as heart rate, breathing, digestion, and more. the investigator has shown that patients with pots have higher cardiovascular and adrenergic activating autoantibodies (aab), which likely changes the normal make-up of pots. there are autoantibodies that have been suggested by a few reports of their presence in pots, but their role different aspects of pots is unknown. the study will look at the body's responses in patients with pots. the crossover study design is to have half of the patients will start with sham followed by active stimulation and half will start by active followed by sham stimulation. it is anticipated that results will provide a potential therapeutic approach based on the understanding of pots.


Eligibility criteria:
inclusion criteria: -female or male participants age 18-80 group 1 (20 participants): * a physician-based diagnosis of pots * participants that have a postural pulse rise of \>35 for adolescents and \>30 for adults with a blood pressure (bp) that does not drop \>10/5 mmhg will be qualified. these participants may be on salt and fluid loading. group 2 (10 participants): * previously diagnosed with pots * patients is on intravenous immunoglobulin (ivig) infusion but who have an incomplete symptomatic response exclusion criteria: * age \< 18 years * sick sinus syndrome, 2nd or 3rd degree atrioventricular (av) block, bifascicular block or prolonged 1st degree av block (pr\>300ms). * currently pregnant women or women planning on becoming pregnant ≤ 6 months * history of hypotension due to autonomic dysfunction * have a secondary causes of tachycardia (acute anemia or blood loss, drugs, significant cardiomyopathy, diabetes mellitus) * patients with active implants (such as a cardiac pacemaker, or a cochlear implant).
treatment of systemic sclerosis with autologous regulatory т-cells

Conditions: Systemic Sclerosis

Summary: treatment of patients with systemic sclerosis with autologous regulatory т-cells

considering the fact that a decrease in the content and functional activity of t-reg plays an important role in the immunopathogenesis of many systemic diseases of the connective tissue, the use of a large amount of t-reg can have a therapeutic effect.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of systemic sclerosis * the patient can read, understand, follow the examination procedures and complete, if necessary, the required documentation * written informed consent exclusion criteria: * the presence of any malignant tumor within the last 5 years * acute or chronic diseases in the stage of decompensation * chronic infectious diseases: hiv, viral hepatitis b, c, tuberculosis * patients who are pregnant, breastfeeding, or fertile patients who are not using adequate contraceptive methods * chronic and protracted mental disorders, all diseases with the presence of the syndrome of dependence on alcohol, drugs and psychoactive substances, any other condition that makes the patient unable to understand the nature, extent and possible consequences of the study or, in the opinion of the researcher, prevents the patient from observing and performing protocol * patients are unable or unwilling to give written informed consent and / or follow research procedures * any other medical condition that, in the opinion of the investigator, may be associated with an increased risk to the patient or may affect the outcome or evaluation of the study
preventative skin care for children undergoing targeted cns tumor therapy

Conditions: Pediatric Cancer; CNS Tumor, Childhood; Skin Inflammation

Summary: this research study is examining a preventive skin care regimen for children diagnosed with a brain tumor and receiving anti-cancer therapy with a mek, pan-raf, or braf inhibitor.

this prospective, single-arm phase 2 clinical trial is looking at whether gentle skin care, sun protection and dilute bleach baths might decrease the chances or the severity of skin changes that occur during treatment for brain tumors. the research study procedures include screening for eligibility and study treatment including evaluations and follow up visits. participants will receive a study treatment regimen that involves a daily sun protection, daily gentle skin care and every-other-day dilute bleach baths for the duration of the study. participants enrolled in this study, will be in this research study during the course of their anti-cancer treatment and receive skin examinations and complete a survey about their skin condition at the initial visit when anti-cancer treatment is started, at six weeks after the start of anti-cancer treatment, and at twelve weeks after the start of anti-cancer treatment. participants will be followed for twelve weeks. it is expected that about 20 people will take part in this research study.

Eligibility criteria:
inclusion criteria: * diagnosed with a brain tumor between ages 6 months old -18 years old and will undergo treatment with at least one of the following: 1. targeted braf inhibitor therapy to treat the brain tumor 2. targeted mek inhibitor therapy to treat the brain tumor 3. targeted pan-raf inhibitor therapy to treat the brain tumor * subjects may participate in other studies, including therapeutic trials. * ability to comply with pscr including sun protection, gentle skin care and every other day dilute bleach baths. * ability to understand and/or the willingness of their parent or legally authorized representative to sign a written informed consent document. exclusion criteria: * diagnosed with brain tumor at \> 18 years old * no data in medical records regarding treatment exposures * treated with a braf, mek or pan-raf inhibitor in the last three months * past or present allergic reaction to bleach * past or present allergic reactions to sunscreen and/or creams, lotions, emollients to be utilized in this study

Keywords: pediatric cancer cns tumor, childhood skin inflammation
dry eye symptom relief assessment with use of truetear in a controlled adverse environment

Conditions: Dry Eye; Dry Eye Syndromes

Summary: this study characterizes acute dry eye symptom control, assessed during exposure to a controlled adverse environment, following use of the truetear for 45 days.

subjects will be instructed to use the truetear daily for approximately 45 days with assessments in the controlled adverse environment taking place on day 0 and day 45. upon entering the cae, participants will complete dry eye symptom questionnaires every five minutes and will administer the device when a certain level of ocular discomfort has been reached.

Eligibility criteria:
inclusion criteria: * have used and/or desired to use an artificial tear substitute for dry eye symptoms within 6 months prior to the screening visit * normal lid/lash anatomy, blinking function and closure as determined by the investigator * literate, able to speak english, and able to complete questionnaires independently exclusion criteria: * chronic or recurrent epistaxis, coagulation disorders or other conditions that, in the opinion of the investigator, may lead to risk of clinically significant increased bleeding * nasal or sinus surgery (including history of application of nasal cautery) or significant trauma to these areas * contact lens use within 7 days prior to the screening visit or anticipate the use of contact lenses at any time during the study * corneal transplant in either or both eyes * cardiac demand pacemaker, implanted defibrillator, or other active implanted metallic or active implanted electronic device in the head * a woman who is pregnant, nursing an infant, or planning a pregnancy during the duration of the study * currently enrolled in an investigational drug or device study or have used an investigational drug or device within 30 days prior to the screening visit
multifocal chromatic pupilloperimetry in patients with pseudotumor cerebri and healthy subjects.

Conditions: Pseudotumor Cerebri

Summary: ptc(pseudotumor cerebri) patients may develop increased intracranial pressure (icp) that can produces increased pressure around the distal optic nerve,which is likely followed by venule compression, ischemia, and loss of visual function.vision loss in ptc is most commonly characterized by standard automated perimetry to measure peripheral visual field sensitivity. pupillometry is a promising approach for functional assessment in ptc because it is noninvasive, objective, performed quickly with minimal patient cooperation needed. the feasibility of using chromatic multifocal pupillometry for assesment of ptc will be examined.


Eligibility criteria:
inclusion criteria: healthy subjects 1. male or female patients, age between 18 and 80 years, inclusive 2. informed written consent will be obtained from all participants. 3. normal eye examination 4. best-corrected visual acuity (bcva) of 20/20 5. normal color vision test (ishihara/hrr) 6. normal spectral-domain optical coherence tomography (sd-oct) 7. normal 24-2 humphrey visual field (sita standard) and: * short duration (≤10 minutes) * minimal fixation losses, false pos errors and false neg errors (less than 33% for each one of reliability indices) ptc patients 1. male or female patients, age between 18 and 80 years, inclusive 2. best-corrected visual acuity (bcva) of at least 20/100 in worse eye 3. optic disc edema 4. ptc diagnosis based on modified dandy criteria ( lumbar puncture with opening pressure higher than or equal to 25 cm h2o, normal cerebrospinal fluid constituents, and unremarkable brain imaging results except typical for ptc exclusion criteria: healthy subjects 1. history of past (last 3 months) or present ocular disease or ocular surgery 2. use of any topical or systemic medications that could adversely influence pupillary reflex 3. intolerance to gonioscopy, slit lamp examination, goldmann applanation tonometry or other schedule study procedure. 4. mental impairment or instability such as that informed consent may not be obtained or compliance with tester instructions is unlikely. 5. visual media opacity including cloudy corneas. 6. any condition preventing accurate measurement or examination of the pupil. ptc patients 1. any other neurologic or ophthalmic disease other than ptc 2. use of any topical or systemic medications that could adversely influence pupillary reflex 3. intolerance to gonioscopy, slit lamp examination, goldmann applanation tonometry or other schedule study procedure. 4. mental impairment or instability such as that informed consent may not be obtained or compliance with tester instructions is unlikely. 5. visual media opacity including cloudy corneas. 6. any condition preventing accurate measurement or examination of the pupil.

Keywords: ptc eyes pseudotumor cerebri increased intracranial pressure icp