Kornimate/medical-research-clean huggingface dataset:
electrical dn as an adjunct to eccentric exercise, stretching + mt for achilles tendinopathy

Conditions: Achilles Tendinopathy

Summary: the purpose of this research is to compare two different approaches for treating patients with achilles tendinopathy: eccentric exercise, stretching and manual therapy vs electric dry needling, eccentric exercise, stretching and manual therapy. physical therapists commonly use all of these techniques to treat achilles tendinopathy. this study is attempting to find out if one treatment strategy is more effective than the other.

patients with achilles tendinopathy will be randomized to receive 8-10 treatments (1-2 treatments per week) over 6 weeks (10 treatments max) of either: (1)eccentric exercise, stretching, manual therapy and electrical dry needling or 2. eccentric exercise, stretching and manual therapy

Eligibility criteria:
inclusion criteria: 1. adult \>18 years old that is able to speak english. 2. report of at least 3 months of achilles pain clinically diagnosed as achilles tendonitis or achilles tendinopathy 3. patient has not had physical therapy, massage therapy, chiropractic treatment or injections for achilles pain in the last 6 months: 4. diagnosis of noninsertional tendinopathy, defined as the following * subjective report of pain located 2-6 cm proximal to the insertion of achilles tendon to the calcaneus, particularly with running or jumping * tenderness to palpation of the achilles tendon while the clinician gently squeezes the tendon between the thumb and index finger in a proximal to distal direction * positive arc sign - intratendinous swelling moves relative to the malleoli with the tendon during active dorsi/plantar flexion * royal london test - tenderness to palpation decreases significantly or disappears with max dorsiflexion exclusion criteria: 1. report of red flags to manual physical therapy to include: hypertension infection, diabetes, peripheral neuropathy, heart disease, stroke, chronic ischemia, edema, severe vascular disease, malignancy, etc. 2. history of previous achilles tendon surgery, ankle arthrodesis, hind foot fracture, or leg length discrepancy of more than one half inch. 3. history of arthrosis or arthritis of the ankle and/or foot. 4. history of significant ankle and/or foot instability 5. two or more positive neurologic signs consistent with nerve root compression, including any two of the following: 1. muscle weakness involving a major lower extremity muscle group 2. diminished lower extremity patella or achilles tendon reflexes 3. diminished / absent sensation in any lower extremity dermatome 6. involvement in litigation or worker's compensation regarding foot pain 7. any condition that might contraindicate the use of electro-needling 8. the patient is pregnant.
program for health promotion to improve therapeutic compliance in hypertensive patiente

Conditions: Hypertension

Summary: the aim was to test if interpersonal relationships group strategies provided by nursing can promote an additional benefit on blood pressure (bp) control and quality of life (qol) in hypertensive patients. methods: 21 treated patients were randomized into two groups: group a 10 patients (8 women), underwent to a health educational orientation program (inter-relational strategy), with group meetings every 15 days during 4 months(8 meetings). group b 11 patients (7 women), who underwent group orientation by the nurse every 40 days during 4 months (3 meetings). both groups received the same content guidelines (healthy lifestyle and prevention of risk factors). the patients had 2 visits by nurses at baseline (15 days) and at the final study (120 days). bp was measured by auscultatory method and qol questionnaire (whoqol-brief)was applied. the dispensing and pill counts were done every 30 days. ambulatory blood pressure monitoring (abpm) was performed at baseline and after 120 days.


Eligibility criteria:
inclusion criteria: * hypertensive patients under treatment regimen; * pressure levels greater than or equal to 90 mmhg diastolic blood pressure (dbp), and * pressure level greater than or equal to 140 mmhg systolic blood pressure (sbp) * age limit between 25 to 75 years, for both female and male. exclusion criteria: * diabetes patients

Keywords: hypertension nursing therapeutic compliance quality of life health education
ophthalmologic evaluation of patients with obesity and metabolic syndrome before and after bariatric surgery

Conditions: Eye Diseases; Obesity Associated Disorder

Summary: the aim of this study was to investigate the pathogenic role of obesity on blinding eye diseases in a population of severely obese patients with no history of eye diseases, and to verify whether weight loss induced by bariatric surgery may have a protective effect.

this was a pilot, monocentric, prospective, and open label study conducted at first affiliated hospital of jinan universityreceived.patients with body mass index ≥ 32.5kg/m2; or patients with body mass index of 27.5-32.5kg/m2 and metabolic diseases were consecutively recruited.all participants underwent complete ophthalmological evaluation， keratograph 5m and optical coherence tomography.patients who underwent bariatric surgery were evaluated also 3 months, 6 months and 1 year after surgery.

Eligibility criteria:
inclusion criteria: 1. patients with bmi≥32.5kg/m2； 2. patients with bmi27.5-32.5kg/m2, combined with metabolic diseases; exclusion criteria: 1. patients with pre-existing ocular diseases or visual alterations were excluded to avoid confounding factors related to pre-existing retinal pathology, independent from obesity per se. 2. patients with dementia, parkinson's disease, alzheimer's disease, multiple sclerosis or other severe neurological diseases were also excluded since ophthalmologic parameters may be altered in these conditions. 3. patients with lens opacities that made impossible the posterior segment examination, or with a refractive error \> +5 or \<-8 diopters spherical equivalent were also excluded.
sleep impairment in subjects at risk of developing alzheimer's disease

Conditions: Neuropathology; Cognitive Decline; Sleep Disorder

Summary: alzheimer's disease (ad) is characterised by a progressive loss of memory and cognitive function. in the early stages of ad, there is a progressive accumulation of molecules: β-amyloid peptides (aβ) in the brain. there is a link between the accumulation of aβ peptides and the deterioration of sleep, but current knowledge does not confirmed this link. the objective of this study is to define whether there is a link between cognitive decline and sleep disorders. if a correlation is found, this could allow earlier treatment of sleep disorders in the longer term in order to slow the development of ad. treatment protocols in the field of alzheimer's disease (ad) are directed towards participants at risk of developing the disease, such as those who carry at least one ε4 allele on apolipoprotein e (apoe ε4). an individual with 2 ε4 copies has a 30-55% risk of developing ad with an age of onset around 68 years and a dose effect of the allele on risk and age of onset of symptoms.


Eligibility criteria:
inclusion criteria: * diagnosis of mild alzheimer's disease with a mms between 21-30 * without anticholinesterase and/or memantine treatment or on stable doses for at least 3 months * no antidepressant or anxiolytic treatment or stopped for at least 15 days * the presence of a family carer to complete neuropsychological scales, questionnaires and sleep diaries * signed informed consent * able to carry out all visits and follow study procedures * affiliation to the french social security system exclusion criteria: * genetic form of alzheimer's disease * insufficient clinical and paraclinical information for the diagnosis of ad * patient living in a nursing home * illiteracy or inability to perform psycho-behavioural tests * major physical or neurosensory problems that may interfere with the tests * patient deprived of liberty, by judicial or administrative decision; * major depression according to diagnostic and statistical manual of mental disorders (dsm-5) * major protected by law; * short-term life-threatening conditions

Keywords: cognitive composite score sleep biomarkers cognitive decline
airway clearance in bronchiectasis: is non-invasive ventilation a useful adjunct in moderate to severe disease?

Conditions: Bronchiectasis

Summary: this clinical trial is investigating the efficacy of non invasive ventilation (niv) as a method of airway clearance in patients with an acute exacerbation and moderate to severe bronchiectasis disease. current treatment focuses on the use of active cycle of breathing techniques (acbt) but this modality alone may not be sufficient when patients have more severe disease and an acute infection. the use of niv may result in better patient care and more appropriate physiotherapy treatment in the more unwell population.the aim of this study is to compare the efficacy of two physiotherapy airways clearance interventions in bronchiectasis.

twenty patients with moderate to severe bronchiectasis admitted to hospital with an acute exacerbation were recruited (october 2004 to april 2006) and allocated to one of two groups that received twice daily airway clearance treatment for a course of ivab. group 1 {acbt} and group 2 {niv and acbt}. a number of measurements were recorded on the first and final day of treatment as well as daily to provide important comparative information on physiological changes, ease of use, and clinical efficacy. outcomes measured on day 1 and final day of ivab were: lifeshirttm which recorded tidal volume; respiratory rate; airway flow; thoracoabdominal coordination; oxygen saturation and heart rate during treatment; respiratory muscle strength (pimax and pemax); spirometry; arterial blood gases (abgs); breathlessness scores; patients perception of tiredness, benefit and ease of treatment; auscultation; number of coughs per treatment; duration of treatment; sputum production, wet and dry weight; sputum rheology. the lifeshirt is a novel technique (respiratory induction plethysmography)which provides data on a wide range of dynamic lung function values (lung volumes; flow volume curves; relative excursion of rib cage and abdomen; spo2) during airway clearance intervention to help understanding of the possible mechanisms of action of different airway clearance mechanisms.

Eligibility criteria:
inclusion criteria: * moderate to severe bronchiectasis (fev1 \< 60%), * indicators of difficulty expectorating sputum, and * an acute exacerbation requiring intravenous antibiotics (ivab) exclusion criteria: * unable to tolerate positive pressure * presence of pneumothorax

Keywords: non-invasive ventilation airway clearance bronchiectasis
daoyin technique for improving exercise endurance in ipf

Conditions: Idiopathic Pulmonary Fibrosis

Summary: this study is based on the previously constructed digital rehabilitation management platform, scientifically evaluating the clinical efficacy of guided technology in improving ipf exercise endurance, and forming high-quality clinical evidence.

this study is based on a digital and intelligent rehabilitation management platform. it collects patients' movement data through intelligent motion capture equipment and heart rate, blood oxygen, and other data using fitness trackers, to complete rehabilitation tracking management, real-time assessment, and effect evaluation. adopting a multi-center,non inferiority, randomized controlled clinical trial design, 236 ipf patients were selected as the research subjects. based on the guideline-directed treatment, the experimental group received guided techniques, while the control group received conventional comprehensive training. the intervention lasted for 3 months, followed by a 3-month follow-up. the primary outcome measures were 6mwd and 30- second sit-to-stand test, while secondary outcome measures included acute exacerbation, fvc, dlco, vo2 peak, mmrc score, ataq-ipf score, etc. the study elucidated the mechanism of action, scientifically evaluated the impact of guided techniques on ipf endurance, and established a guided technique protocol for ipf.

Eligibility criteria:
inclusion criteria: 1. patients who meet the diagnostic criteria for ipf; 2. those who can tolerate guided - technique training; 3. aged between 40 and 85 years old; 4. those who can independently or with the assistance of family members use devices such as smartphones and computers during home - based training; 5. those who voluntarily accept treatment and sign the informed consent form. exclusion criteria: 1. patients in the acute exacerbation phase of ipf. 2. patients with comorbidities such as chronic obstructive pulmonary disease, lung cancer, active pulmonary tuberculosis, bronchiectasis, pulmonary embolism, and other pulmonary diseases. 3. patients with severe cardiovascular and cerebrovascular diseases (malignant arrhythmia, unstable angina pectoris, acute myocardial infarction, cardiac function at grade 3 or above, stroke, cerebral hemorrhage, etc.). 4. patients with severe liver diseases (such as bleeding caused by liver cirrhosis, portal hypertension, and esophagogastric varices) and severe kidney diseases (dialysis, kidney transplantation, etc.). 5. patients with severe osteoarthropathy or osteoporosis, and those with unstable fractures. 6. patients with progressive neuromuscular diseases. 7. patients with unclear consciousness, dementia, and various mental illnesses. 8. pregnant or lactating women, and patients with a recent pregnancy plan. 9. patients who have been participating in other clinical trials within 1 month before enrollment. 10. patients who need long - term use of ventilators and those with unstable vital signs while bedridden.

Keywords: idiopathic pulmonary fibrosis daoyin technique randomized controlled trial
ngs genome analysis in personalisation of lung cancer treatment

Conditions: Lung Cancer

Summary: the identification of driver mutations in the epidermal growth factor receptor (egfr) as the primary oncogenic event in a subset of lung adenocarcinomas led to a model of targeted treatment and genetic profiling of the disease. egfr tyrosine kinase inhibitors (tkis) confer remission in some patients, but use of the egfr-tkis is limited to patients with adenocarcinomas who have known activating egfr mutations. and resistance to tki treatment has become an increasingly important cause of treatment failure. therefore, identification of the molecular components involved could lead to the development of effective therapy. today only a limited number of genetic alterations are studied. next generation sequencing (ngs) has the potential of becoming an important tool in clinical and therapeutic decision-making in oncology owing to its enhanced sensitivity in dnd mutation detection.


Eligibility criteria:
inclusion criteria: * patients of bronchial adénocarcinoma with metastases can benefit from first-line therapy - targeted therapy by tyrosine kinase inhibitor(tki) for egfr mutation and chemotherapy for non egfr mutation) * patients with epidermoid cancer of the lungs can benefit from chemotherapy * man and women * age ≥ 18 years * patients have signed a written informed consent form * patients are affiliated to s social health insurance exclusion criteria: * survival time ≤ 3 months * patients with cerebral metastases * patients could not benefit from treatment for others diseases * pregnancy or breast-feeding * incapacity to sign the consent form for psychiatric, behavioural disorders * private individuals of freedom or under tutelage

Keywords: lung cancer, mutations patients mutations
executive functioning and mindfulness in adults with attention deficit/hyperactivity disorder imaging

Conditions: Attention-deficit/Hyperactivity Disorder

Summary: the main purpose of this study is to evaluate changes in brain functioning using an mri machine following mindfulness meditation training.

the broad objective of this proposal is to identify functional neuroanatomical correlates of changes in executive brain functioning prior to and following an 8-week, group-based mindfulness meditation intervention within a group of 10 adults diagnosed with attention-deficit/hyperactivity disorder (adhd). another group of 10 adults diagnosed with adhd will be placed in the waitlist condition. our primary hypothesis is that adults with adhd in the treatment group will exhibit improved performance on a series of executive functioning tasks and that exposure to task stimuli will correspond to changes in neural functioning following an 8-week, group-based mindfulness intervention. brain responses will be measured using blood-oxygenation-level-dependent (bold) fmri signal in brain regions associated with emotional and executive processes prior to and following treatment.

Eligibility criteria:
inclusion criteria: * ages 18-50 years * meet dsm-iv criteria for adhd * intellectual functioning ≥ 80 as assessed by an iq screener * generally healthy (i.e., no major medical problems) exclusion criteria: * major medical condition that would make participation unsafe (e.g., have pacemaker or other metallic implant), uncomfortable (e.g., chronic pain) * claustrophobic, or abnormally afraid of closed-in places * current drug use

Keywords: attention-deficit/hyperactivity disorder executive functioning mindfulness meditation magnetic resonance imaging healthy
evaluation of periodontal response to non surgical therapy in pre and post menopausal women with periodontitis

Conditions: Periodontitis; Menopause; Plaque; Inflammation

Summary: the present study was evaluated periodontal status in pre and post-menopausal women with periodontitis following non-surgical therapy.

aim: the aim of the present study was to evaluate periodontal status in pre and post-menopausal women with periodontitis following non-surgical therapy. materials and methods: periodontal status was measured by periodontal index (pri), and oral hygiene status was measured by plaque index (pi). both the parameters were measured at baseline i.e before scaling and root planing (srp) and after 3 months intervals post treatment. srp was done in both pre\&post menopause groups.

Eligibility criteria:
inclusion criteria:patients should have at least 15 natural teeth remaining * non smokers * systemically healthy from past 6 months exclusion criteria:present or past smokers * below 40 years of age * with gross oral pathology or tumors * patients on long term steroid medication * undergoing hormone replacement therapy (hrt) * pregnant women or planning for pregnancy * those who have received periodontal therapy in the preceding 6 months * those that are under medication in the preceding 6 months * any systemic disorders or any medication that affects the periodontal status was excluded from this study.

Keywords: non surgical therapy
the analgesic effect of nefopam on the fentanyl based pca (patient-controlled analgesia) after lumbar spinal surgery

Conditions: Lumbar Spinal Stenisis or Lumbar Herniated Intervertebral Disc

Summary: posterior lumbar spinal surgical pain leads to a severe degree of pain, and, hence, various means of pain management are required. opioid pain medications such as morphine and fentanyl are frequently used as intravenously administered medications. to reduce the use of opioids for pain relief, a non-opioid form of pain relief, such as a non-steroidal anti-inflammatory drug (nsaid), is often added to the regimen. with the use of nsaids, however, the risk of systemic side effects such as bleeding, gastroduodenal bleeding, and kidney damage are being reported, and there is also a report of inhibition of spinal fusion; these risks limit the use of nsaids. nefopam, a new centrally-acting analgesic agent, has been reported in an animal study to desensitize post-surgical pain, and when used with an opioid analgesic, it indirectly controlled the nmda receptor, which inhibited the generation of c-fos gene at the spine. there are also reports that nefopam managed pain by inhibiting the serotonin reuptake receptors. in clinical practice, the administration of nefopam in patients who required post-surgical pain management reduced the use of opioid analgesics by 20-50 % and also reduced the prevalence of nausea and vomiting. therefore, the investigators considered whether the addition of nefopam for intravenous patient-controlled analgesia in patients with lumbar spinal surgery would reduce the side effects seen in monotherapy with opioid analgesia and result in effective pain management. this study was conducted to address this question.


Eligibility criteria:
a. inclusion criteria: the study subjects were adult patients, 20-65 years old, who were going to have spinal fusion surgery due to conditions such as spinal stenosis or disks and who fell under the american society of anesthesiologist physical status classifications of 1 or 2. b. exclusion criteria: patients who could not read or understand the consent documents or who had a defect in blood coagulation, hepatectomy, pneumonectomy, nephrectomy, cardiovascular disease, administration of mao inhibitor, ischuria, glaucoma, or a history of seizure were excluded from the study.

Keywords: nefopam, spinal surgery, postoperative pain control
extended pessary interval for care (epic study)

Conditions: Pelvic Organ Prolapse; Pessary

Summary: objectives: pelvic organ prolapse (pop) is a common condition for which pessaries are commonly used in conservative treatment. despite their prevalence, there is no literature to guide the management of pessaries. our objective is to determine whether patients managed with a pessary for pop are more satisfied with follow-up at 3 or 6 month intervals and if there is any difference in complications rates between the two groups. hypothesis: the investigators hypothesize that there will be higher patient satisfaction in the group randomized to 6 month follow-up intervals and that there will be no difference in complication rates between the two follow-up groups. method: the investigators will conduct a prospective randomized control trial comparing patient satisfaction and complication rates between patients with pessaries randomized to either 3 or 6 month follow-up intervals over 1 year.


Eligibility criteria:
inclusion criteria: * females with pop who have opted for conservative management with a pessary * able to read and write english * first time pessary users * successful fitting with a covered ring or gellhorn pessary, as determined at the usual early follow-up visit 2-4 weeks after initial fitting (successful defined as: no expulsion on movement, squatting or valsalva, no urinary retention, no discomfort, and still retained pessary after 2 weeks) * patients agree to use vaginal estrogen (either tablet or cream twice weekly) during the study period; patients may not use a vaginal estrogen ring since this requires changing every 3 months, and will interfere with the study follow-up schedule exclusion criteria: * current presence of vaginal bleeding, vaginal abrasions or ulcers, or vaginal infection * significant cognitive impairment * pessary used for indication other than pop (ie. urinary incontinence) * use of a pessary that is not a covered ring or gellhorn (i.e exclude cube, donut, etc.) * contraindications to vaginal estrogen * unsuccessful pessary fitting (successful defined as: no expulsion on movement, squatting or valsalva, no urinary retention, no discomfort, and still retained pessary after 2 weeks)

Keywords: pelvic organ prolapse pessary