Kornimate/medical-research-clean huggingface dataset:
quantitative bowel readiness assessment system in predicting the missed detection rate of adenomas

Conditions: Self Control; Prospective; Interventional

Summary: to verify the correlation between the proposed artificial intelligence based bowel preparation assessment system and the missed detection rate of adenomas, and to evaluate whether the system can effectively assist doctors in identifying patients who need to be re-examined by colonoscopy due to poor intestinal cleanliness.


Eligibility criteria:
inclusion criteria: at least 4 operators were included in this study, and the operating years of colonoscopy were ≥ 5 years, and the number of independent operating cases was ≥ 3000. subjects who meet all of the following specific criteria will be considered for participation in the study: 1. male or female with age ≥ 45 years inclusive; 2. able to read, understand and sign informed consent; 3. the investigator believes that the subjects can understand the process of the clinical study, are willing and able to complete all study procedures and follow-up visits, and cooperate with the study procedures. exclusion criteria: subjects who meet any of the following specific criteria will be refused to participate in the study: 1. have a history of drug or alcohol abuse or psychological disorders within the last 5 years; 2. pregnant or lactating women; 3. patients with known multiple polyp syndrome; 4. patients with known inflammatory bowel disease; 5. known intestinal stenosis or space-occupying tumor; 6. known colon obstruction or perforation; 7. patients with a history of colorectal surgery; 8. patients with previous history of allergy to pre-used spasmolysis; 9. unable to perform biopsy and polyp removal due to coagulation disorders or oral anticoagulants; 10. high risk diseases or other special conditions that the investigator considers the subject unsuitable for participation in the clinical trial.
the effect of thyroid antibodies on female reproductive function and pregnancy outcomes

Conditions: Thyroiditis, Autoimmune

Summary: some women at reproductive age have positive antithyroid antibodies (atas). thyroid peroxidase antibody (tpoab) and thyroglobulin antibody (tgab) are the most common atas. this study aimed to evaluate the impact of atas on maturation of women reproductive system and pregnancy outcomes.


Eligibility criteria:
inclusion criteria: * age during 18-45y; * women tested for tpoab and/or tgab, tsh, free t3, free t4, total t3 and total t4 during the 1st trimester of pregnancy exclusion criteria: * multiple pregnancies; * age \ 40 y; * l-t4 or ptu intervention before pregnancy; * other autoimmune diseases.
assessment of oral health related quality of life after full mouth rehabilitation under ga

Conditions: Quality of Life

Summary: to assess oral health related quality of life (ohrqol) after full mouth rehabilitation under ga in a group of egyptian children with special healthcare need.

* the study will be conducted in department of pediatric dentistry and dental public health, faculty of dentistry, cairo university, egypt. * demographic variables (caregiver age and gender), socio-economic condition, , medical history, and dental history will be collected from the parent or caregiver. the height and weight of each child will be measured in the same manner to standardize the result and their body mass index will be calculated before and after in follow up period. * on the day of the ga, parent or caregiver will complete questionnaires about their child's oral state and well-being over the previous 3 months and oral hygiene instructions will be given to the parent. * the questionnaire will be delivered to the parents/caregivers at baseline and at the 6-month post-operative follow-up visit. dental examination will be assessed at baseline (pre-operatively) and at 1,3, 6, months post-operative visits.

Eligibility criteria:
inclusion criteria: 1. age range 5 to 14 years. 2. diagnosed with physical, mental, or sensory disability (separately or combined). 3. should have a minimum of 12 primary or permanent teeth, or a mixture that had not been treated within the past 12 months. exclusion criteria: 1. participation in any other concurrent clinical trials. 2. the presence of serious medical conditions or a transmissible disease such as malignant disease, hepatitis, aids etc. 3. children whose parents had no home or mobile phone to enable post-operative contact. 4. parent that will not sign the consent.

Keywords: rehabilitation children with disabilities general anesthesia children with special healthcare need handicapped children full mouth rehabilitation
cogmed for working memory after tbi

Conditions: Traumatic Brain Injury

Summary: this study will examine a cognitive rehabilitation protocol targeted at working memory deficits for adults and children with traumatic brain injury (tbi). in this randomized clinical trial, the efficacy of cogmed, a cognitive rehabilitation protocol designed to improve working memory, will be examined in children with tbi. neuropsychological and daily life functioning will be measured. participants will be children (n=20) and adults (n=20) with a documented history of tbi. participants will be randomized to a treatment group or a wait list control group. the experimental group will receive the cogmed working memory training program 30-40 minutes per day, 5 days a week for 5 weeks for a total training time of approximately 15 hours. the control group will be a wait list control group that will cross over into treatment after the follow-up assessment. all subjects will undergo repeat assessments following completion of the working memory training protocol after the 7th week and again at 13 weeks to document changes in working memory performance.


Eligibility criteria:
inclusion criteria: * history of traumatic brain injury exclusion criteria: * diagnosis of other neurological conditions

Keywords: working memory
pantoprazole in cisplatin nephrotoxicity

Conditions: Oncology

Summary: pantoprazole in cisplatin nephrotoxicity

pantoprazole in cisplatin nephrotoxicitypantoprazole in cisplatin nephrotoxicity. is it protective?

Eligibility criteria:
inclusion criteria: * patients with head and neck cancer exclusion criteria: * gfr less than 59. * dm * elevated liver enzymes more than 3 fold.
jak-i on ra b-lymphocytes tolerance and disease resolution through jak signaling in rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the study will reveal the transcriptomic signature linked to the aberrant activation of b lymphocytes in ra identifying novel molecular potential targets for inflammation resolution and immune tolerance promotion. the combination with b lymphocytes phenotyping will dissect the impact of the identified genes on b lymphocyte maturation and activation in ra. moreover, in vitro study on b lymphocyte cultures using selective jak1 inhibition will reveal, at deeper level, its transcriptomic effect on ra b lymphocytes activation profile and phenotype, providing the discovery of new biomarkers of the loss of immunological tolerance, active disease and long lasting disease remission.


Eligibility criteria:
inclusion criteria: 1. signed written informed consent. before any study procedures are performed,subjects will have the details of the study described to them, and they will be given a written informed consent document to read. then, if subjects consent to participate in the study, they will indicate that consent by signing and dating the informed consent document in the presence of trained study personnel. 2. patients fulfilling classification criteria for rheumatoid arthritis (2010 acr/eularclassification criteria) 3. age: 18-70 years 4. for preclinical cohort: individuals with positivity for acpa or igm/iga rf without clinical signs of arthritis, whose positivity is not related to other concomitant pathologic conditions. 5. for naive to treatment cohort: ra patients without previous exposure to conventional dmards or biologic/targeted synthetic-dmards. 6. for resistant to treatment cohort: ra patients with failure to previous conventionaldmards for inadequate response or side effects. 7. for remission ra cohort: ra patients in sustained clinical and ultrasound remission as stated in section 3.3.1. 8. for healthy control cohort: healthy donors will be aged from 18 to 70 years. exclusion criteria: 1. severe and uncontrolled infections such as sepsis and opportunistic infections. 2. patients who are currently included in any interventional clinical trial in ra. 3. ra patients in therapy with other biologics. 4. healthy donors receiving anti-inflammatory drugs

Keywords: rheumatoid arthritis
oral health status in patients with cirrhosis and effect of dental treatment on meld score of cirrhosis patients

Conditions: Liver Cirrhosis; Periapical Lesions

Summary: it has been found that there is an association between prevalence of odontogenic infection and systemic diseases.cirrhosis has also been associated with poor oral health status.treating those patients accordingly can help in reducing the source of infection to some extent and may be associated with reduction in mortality.

patients will be selected according to inclusion and exclusion criteria.written informed consent will be taken from each participant after being informed about study .there will be two groups1) cirrhosis patients 2)normal healthy patients.prevalence of apical periodontitis will be measured in both groups by intraoral examination,digital panoramic radiography.. meld score will be recorded in cirrhosis patients at this stage.non surgical root canal treatment will be performed in teeth with apical periodontitis. periapical healing will be checked with the help of pai score given by orstavik. in cirrhosis patients meld score will be measured before and after treatment.

Eligibility criteria:
inclusion criteria:(cirrhosis patients) 1. known patient of cirrhosis(diagnosis of cirrhosis is based on blood testing, medical imaging, and liver biopsy.) with mature permanent teeth . 2. age35-55 years 3. \> or equal to 8 natural teeth(excluding 3rd molars); 4. i.n.r \< 3.5 - exclusion criteria:(cirrhosis patients) 1. patient having systemic disorders other than hepatic disease(e.g. hiv, osteoporosis,diabetes,cardiovascular disease) 2. pregnancy 3. use of systemic and topical antibiotic treatment within 3 months prior to the start of the study. the eligibility criteria of the control group were the same for the cirrhosis group, except for the presence of liver disease. cirrhosis patients were matched with controls according to sex, age (± 3 years old) and current smoking status and alcohol satus (yes/no). -

Keywords: apical periodontitis liver disease root canal treatment
cardiac complications in patients with sars corona virus 2 (covid-19) registry

Conditions: COVID-19; Cardiovascular Diseases

Summary: capacity (www.capacity-covid.eu) is a registry of patients with covid-19 across europe and has been established to answer questions on the role of cardiovascular disease in this pandemic. it is an extension of the case record form (crf) that was released by the isaric (international severe acute respiratory and emerging infection consortium) and who (world health organisation) in response to the emerging outbreak of covid-19.

the aim of capacity is to collect data regarding the cardiovascular history, diagnostic information and occurrence of cardiovascular complications in covid-19 patients. by collecting this information in a standardized manner, capacity can aid in providing more insight in (1) the incidence of cardiovascular complications in patients with covid-19, and (2) the vulnerability and clinical course of covid-19 in patients with an underlying cardiovascular disease. the capacity extension to the isaric-who crf consists of additional data collection instruments for: * cardiac history and cardiovascular risk factors * prior use of cardiac medication or nsaids * electrocardiography (ecg) * echocardiography * cardiac mri * invasive cardiac procedures * cardiac complications * cardiac biomarkers * cardiac outcome during admission

Eligibility criteria:
inclusion criteria: * highly suspected/confirmed infection with sars-cov-2 exclusion criteria: - patients that opt-out
a study of experimental medication bms-986036 in adults with nonalcoholic steatohepatitis (nash) and liver cirrhosis

Conditions: Hepatic Cirrhosis; Liver Fibrosis; Nonalcoholic Fatty Liver Disease (NAFLD); Nonalcoholic Steatohepatitis

Summary: this is a study of experimental medication bms-986036 given to adults with nonalcoholic steatohepatitis (nash; the buildup of fat and inflammation in the liver that is not caused by alcohol) and liver cirrhosis (liver damage characterized by normal liver tissue being replaced by scar tissue).


Eligibility criteria:
inclusion criteria: * liver biopsy performed within 6 months (26 weeks) prior to the screening period. if historical biopsy is not available, a liver biopsy will be performed during the screening period. biopsy must be consistent with nash and cirrhosis according to the nash crn classification, as assessed by the central reader * must be taking anti-diabetic, anti-obesity, or anti-dyslipidemic medications must have been on stable regimens for at least 3 months (12 weeks) (6 weeks for statins) prior to and during the screening period * participants taking vitamin e at doses greater than or equal to (\>=) 800 iu/day must have been on stable doses for at least 6 months (26 weeks) prior to and during the screening period. vitamin e treatment (\>=800 iu/day) must not have been initiated after the qualifying liver biopsy was performed exclusion criteria: * other causes of liver disease (e.g., alcoholic liver disease, hepatitis b virus infection, chronic hepatitis c virus infection \[hcv\], autoimmune hepatitis, drug-induced hepatotoxicity, wilson disease, α-1-antitrypsin deficiency, iron overload, and hemochromatosis); participants with hcv sustained viral response (undetectable hcv rna) for at least 2 years prior to biopsy confirming study eligibility may be eligible * current or past history of hepatocellular carcinoma (hcc) * past or current evidence of hepatic decompensation (e.g., ascites, variceal bleeding, hepatic encephalopathy and/or spontaneous bacterial peritonitis) or liver transplantation * medical history of gastroesophageal varices, except if esophagogastroduodenoscopy \[egd\] performed within 12 months prior to the screening period has shown \<= grade 1 varices other protocol-defined inclusion/exclusion criteria apply
effects of reformer pilates exercise training

Conditions: Physical Performance

Summary: aim: the aim of the study is to investigate the effects of reformer pilates exercises in overweight and obese woman. method: 47 sedentary overweight and obese women aged 30-60 years will be included in the study. subjects will be divided into two groups: reformer pilates and control. the exercise group will be given reformer pilates training session 3 times a week over an 8-weeks period. before and after the study, the subjects will be test for body composition with the bioelectrical impedance and for upper limb strength with the hand grip dynamometer. moreover, the strength of the back muscle will be measure with the back dynamometer and the strength of the abdominal muscle with the sit-up test. furthermore, the endurance of trunk, abdominal and back muscles will be measure with the mcgill endurance tests. the endurance of the lower limb will be measure with the 30 second sit and stand test, and the balance with the fullerton advanced balance scale. finally, the sleep quality will be measure with the pittsburgh sleep quality index, and the anxiety with the hospital anxiety and depression scale.


Eligibility criteria:
inclusion criteria: * volunteer female individuals between the ages of 30-60 years, * bmi: 25 kg/m² and above, * individuals who have not surgery in the last 6 months, * individuals who have a medical report stating that there is no obstacle in terms of health, * individuals whose physical activity level will be determined by the international physical activity questionnaire (ipaq) will be included in the study. exclusion criteria: * individuals with any neurological, orthopedis, cardiovascular, psychological problems, * individuals with any systemic disease (dm, cancer), * individuals who doing regular physical activity/sport in the last 6 months.

Keywords: exercise
efficacy and safety assessment of t4020 versus vehicule in patients with chronic neurotrophic keratitis or corneal ulcer

Conditions: Keratitis; Corneal Ulcer

Summary: the purpose of this study is to assess the efficacy and safety of t4020 versus vehicle.


Eligibility criteria:
inclusion criteria: * adult patients diagnosed with one chronic keratitis/corneal ulcer * patients who signed and dated informed consent exclusion criteria: * patient under 18 years * patient with a perforated corneal ulcer or any risk of immediate perforation of corneal ulcer.
treating insomnia & nightmares after trauma: impact on symptoms & quality of life

Conditions: Nightmares; Insomnia; Posttraumatic Stress Disorder

Summary: exposure to trauma, especially when it manifests as posttraumatic stress disorder (ptsd), results in numerous negative consequences for patients, families, and society. some of the most frequent, disturbing, and treatment resistant symptoms of ptsd are nightmares and insomnia. this study will examine whether treatments specifically targeted at those sleep disorders can improve clinical outcomes and increase health-related quality of life in individuals recently exposed to war-related trauma. hypotheses are that treating nightmares and insomnia will improve both nighttime and daytime symptoms of ptsd, as well as quality of life.


Eligibility criteria:
inclusion criteria: * 1 or more deployments to oef or oif * exposure to trauma * nightmares 2 or more times per week * insomnia for 1 month or more * live in greater san diego county region exclusion criteria: * use of medications for sleep or nightmares in the past 2 weeks * current enrollment in psychotherapy for ptsd * current or recent substance or alcohol abuse or dependence * other untreated sleep disorders (e.g., sleep apnea)

Keywords: sleep sleep disorder veterans active duty oef oif ptsd
pre-approval access to jnj-53718678 for the treatment of respiratory syncytial virus (rsv) infection in (a) immunocompromised adult and pediatric participants

Conditions: Respiratory Syncytial Virus

Summary: the purpose of this pre-approval access program is to provide treatment to immunocompromised participants with serious/life-threatening diseases or conditions (respiratory syncytial virus \[rsv\] infection) and to collect the safety data to understand the safety profile of jnj-53718678.


Eligibility criteria:
intermountain risk score and trauma

Conditions: Trauma; Injury

Summary: the investigators hypothesize that a risk score composed of age, sex, and the components of commonly ordered laboratory panels will be predictive of mortality in trauma patients, and will help improve clinicians' ability to make more accurate mortality predictions at the time of admission.


Eligibility criteria:
inclusion criteria: * patient presents to intermountain medical center as a level i or level ii trauma activation. * age ≥18 exclusion criteria: * patients who are not admitted to the hospital 1. patients who expire in the emergency department 2. patients who are discharged to home from the emergency department * patients who do not have a complete blood count and basic metabolic profile drawn in the emergency department as part of routine clinical care. * patients who enter the hospital as "trauma consults." these patients have traumatic injuries, and are often admitted to the trauma service, but the severity of their trauma is not thought to warrant trauma team activation.

Keywords: trauma scoring systems intermountain risk score
lens extraction combined with goniosynechialysis versus trabeculectomy

Conditions: Glaucoma, Angle-Closure

Summary: to compare the effectiveness of lens extraction combined with goniosynechialysis and trabeculectomy in treating advanced angle-closure glaucoma.

advanced angle closure glaucoma (aacg) can result in severe visual function defect or even blindness with or without acute attacks. different from open angle glaucoma (oag), the main principle of treatment for aacg is not only to lower intraocular pressure (iop) but also to protect the anterior chamber angle from closing. previously, the most common and classical treatment for aacg was trabeculectomy. however, both doctors and patients are not satisfied with this surgery because of its limited success rate due to fibrosis of the filtration pathway. besides, trabeculectomy has various complications, such as shallow anterior chamber, choroidal effusion, suprachoroidal hemorrhage, malignant glaucoma, and bleb leakage associated endophthalmitis. in addition, patients who underwent trabeculectomy will have decreased visual acuity in a couple of years due to accelerated development of cataract. since a thickened and anterior-positioned lens could play a crucial role in the pathogenesis of aacg, cataract surgery has also been used. accumulative evidence shows lens extraction alone is an efficient way in treating the early stage of acg but has limited success rate in aacg. lens extraction combined with goniosynechialysis (leg) has been proved to be better than lens extraction alone in re-opening the anterior chamber angle for acg patients with extensive peripheral anterior synechia and possibly have better effect than trabeculectomy as well from our preliminary data, which has not been proved yet. thus, this investigation is designed to compare the effect of leg and trabeculectomy in aacg patients prospectively in 3 years of follow-up. the investigators hypothesize that leg could have better iop control and better visual function than trabeculectomy in long term for aacg patients.

Eligibility criteria:
inclusion criteria: 1. age between 40 years old to 80 years old 2. more than 180-degree synechial closure of anterior chamber angle on gonioscopy 3. iop higher than 21mmhg under the use of more than two anti-glaucoma eye drops 4. mean deviation of visual field worse than -12db on humphrey 24-2 5. phakic eyes exclusion criteria: 1. snellen visual acuity worse than 0.02 2. history of ocular trauma 3. uveitis 4. previous ocular surgeries 5. significant conjunctival scar 6. visible neovascular on iris or anterior chamber angle 7. other severe eye diseases that would affect visual function significantly, such as age-related macular degeneration and pathogenic myopia.

Keywords: phacoemulsification goniosynechialysis trabeculectomy
short intervention for medication overuse headache (moh) - pilot

Conditions: Medication Overuse Headache

Summary: the purpose of the study is together with the bimoh (nct01314768) rct study to evaluate whether training of gps in the detection and treatment of medication overuse headache leads to improved care for these patients as compared to "business as usual".

the present pilot study focuses on testing the logistics and the methodology of short intervention on a pilot group of gps and their patients. due to low recruitment and the pilot study focus on logistics and methodology, the study was changed to not include a control (business as usual) arm. the outcomes were evaluated as "before - after" data and qualitative comments on acceptability and utility of the method. primary outcomes were changed to be the acceptability and utility (previously listed as secondary outcomes) while secondary outcomes were headache days and medication days (previously listed as primary).

Eligibility criteria:
inclusion criteria: * diagnosed with medication overuse headache exclusion criteria: * other complicating pain condition