Kornimate/medical-research-clean huggingface dataset:
the men on the move study

Conditions: Physical Inactivity; Mobility Limitation; Older Men

Summary: the men on the move study is a randomized, controlled, feasibility study designed to address the health problem of physical inactivity in older men.

men on the move is a randomized, controlled, feasibility study to provide preliminary evidence of feasibility and efficacy for promoting mobility through the uptake of physical activity among men aged 65 years and older who are physically inactive. specifically, men on the move will evaluate the effects of a choice-based physical activity model paired with an active transportation model. the choice-based physical activity model encourages older men to use existing community-based resources to create and implement actions plans for physical activity. it also provides ongoing face-to-face and telephone-based support from trained activity coaches. the active transportation model provides transit passes and active travel planning to promote use of transit and walking to destinations of interest. the feasibility of delivering the intervention will be assessed. accelerometry and travel diaries will be used to measure the effects of the intervention on physical activity.

Eligibility criteria:
inclusion criteria: 1. 65 years of age and older; 2. identify as a man; 3. english speaking; and 4. demonstrate readiness for physical activity (by the par-q+ questionnaire or a letter of recommendation from their physician) exclusion criteria: 1. participated in any strength training in the past 3 months; 2. participated in any aerobic exercise class in the past 3 months; 3. live in a nursing home or assisted living facility; or 4. have plans to be out of town for more than 7 days during the 12-week intervention period.
a research study to compare two forms of semaglutide in two different pen-injectors in people with overweight or obesity

Conditions: Overweight; Obesity

Summary: the study will look at how two different forms of semaglutide reach and stay in the blood after injection. none of the two forms of semaglutide have been approved by the authorities to treat obesity. participants will get 1 of the 2 forms of semaglutide - which one is decided by chance. participants will get the medicine as an injection under the skin of the stomach with the use of a pen-injector. the type of pen-injector is different for the two forms of semaglutide. the study staff will teach participants how to inject themselves with the medicine. as part of this training participants will self inject placebo (dummy medication) 3 times. participants will take an injection once a week and will get 21 injections in total of study medication. the study will last for about 27-30 weeks. participants will have 25 study visits with the study doctor. for 2 of the visits, participants will stay in the clinic for 3 days and 2 nights. participants may have to stop the study if the study doctor thinks that there are risks for their health. women cannot take part if they are pregnant, breast-feeding or planning to become pregnant during the study period.


Eligibility criteria:
inclusion criteria: * male or female, aged 18-65 years (both inclusive) at the time of signing informed consent * body mass index (bmi) between 27.0 and 34.9 kg/m\^2 (both inclusive) * body weight between 70.0 and 130.0 kg (both inclusive) exclusion criteria: * female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using a highly effective contraceptive method * any disorder which in the investigator's opinion might jeopardise subject's safety or compliance with the protocol * inability or unwillingness to perform self-injection
study evaluating etanercept and methotrexate in plaque psoriasis

Conditions: Psoriasis; Arthritis, Psoriatic

Summary: the purpose of this study is to evaluate the efficacy to clear or almost clear the plaques in plaque psoriasis patients, treated with the combination etanercept and methotrexate compared to etanercept alone.


Eligibility criteria:
inclusion criteria: * active plaque psoriasis involving \>10% body surface area and/or minimal screening pasi score 8. * methotrexate \>7.5 mg/week for the last 3 months exclusion criteria: * predominantly guttate, erythrodermic or pustular psoriasis * other skin conditions than psoriasis

Keywords: psoriasis arthritis
pulse oximeter for sleep evaluation

Conditions: Obstructive Sleep Apnea

Summary: the investigators will conduct this study to validate belun ring for sleep assessment. the investigators will compare belun ring data collection and overnight in-lab polysomnography (psg) measures of sdb and sleep architecture in adults with osa symptoms. the investigators propose to recruit a total of 40 participants with symptoms of obstructive sleep apnea. the investigators will i) validate the overall accuracy, sensitivity and specificity of belun ring to assess sdb and sleep architecture, using psg analysis as a gold standard.


Eligibility criteria:
inclusion criteria: 1. age between 18 to 80 years old. ideally balanced for sex and age (18 to 80 years old) * no more than 75% of subjects in one bin of: (male, female) * no more than 50% of subjects in one age-group (18-29, 30-39, 40-49, 50-59, 60-80) 2. patients with osa symptoms (snoring, excessive daytime sleepiness or witnessed apnea, etc.) 3. without any unstable medical or psychiatric co-morbidities that would be expected to interfere with the study. 4. if taking any medication, must be on a stable dose of medication for a month 5. able to read and understand english exclusion criteria: 1. presence of any significant systemic or unstable medical condition which could lead to difficulty complying with the protocol, suicidality, current regular use of psychiatric medications, opiates, or thyroid medications, dementia, current substance abuse, post-traumatic or psychotic disorders, bipolar disorder; any significant neurologic disease, including possible and probable dementia, parkinson's or huntington's disease, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, history of significant head trauma, history of alcohol or substance use disorder within the past 2 years (dsm v criteria); 2. if positive airway pressure (pap) titration study or split night study (diagnostic and pap titration study combined) 3. under 18 or over 80 years of age

Keywords: obstructive sleep apnea pulse oximeter polysomnography
fecal microbiota transplantation for ibs

Conditions: Irritable Bowel Syndrome; Diarrhea

Summary: the purpose of this study is to learn the efficacy and safety of fecal microbiota transplantation (fmt) using stool from a donor with low proteolytic activity and containing the bacteria alistipes putredinis in patients with irritable bowel syndrome (ibs) and high proteolytic activity. proteolytic activity is the breakdown of proteins into smaller polypeptides or amino acids.


Eligibility criteria:
inclusion criteria: * ibs defined by rome iv criteria * non ibs-c * moderate to severe symptoms defined by ibs-sss≥175 * able to safely undergo and consent to colonoscopy exclusion criteria * immune deficiency or treatment with immunosuppressive medications * severe bowel or medical disease precluding administration of bowel prep * severe bowel or medical disease precluding colonoscopy with conscious sedation * active cancer * pregnant or lactating * abdominal surgery (exception of splenectomy, partial hepatectomy, partial/unilateral nephrectomy, laparoscopy, pelvic floor repair, mesh, liposuction, fundoplication, tubal ligation, gastric sleeve, oophorectomy, hernia, appendectomy, cholecystectomy, caesarean section and hysterectomy) * severe psychiatric disorder (hads-a or d\>16), or diagnosed alcohol or drug abuse disorder * new probiotics or treatment with antibiotics, nsaids (within 4 wks prior to study entry) * use of treatments known to affect colonic motility (with exception of loperamide) * diagnosed h/o bleeding disorder * organic gi diseases (ibd, celiac disease, microscopic colitis) * chronic kidney or liver disease * absolute neutrophil count (anc) \<500 iu/ml

Keywords: post-infection irritable bowel syndrome with diarrheal post-infection irritable bowel syndrome with mixed symptoms
effects of spinal cord injury on female sexual response

Conditions: Female Sexual Dysfunction; Multiple Sclerosis; Spinal Cord Injury

Summary: the long term aims of this project are to 1) understand the effect of varying degrees and levels of sci and dysfunction(sci/d)on females sexual response: 2) identify the specific neuronal pathways involved in female sexual responses; and 3) develop and evaluate new assessment and treatment methods for neurogenic sexual dysfunction in women.


Eligibility criteria:
inclusion criteria: * ms or sci * normal menstrual periods * normal hand function * have ability to feel sensation from lower abdomen to upper thigh region. exclusion criteria: * pregnant * menopausal

Keywords: sexual response sexual dysfunction in females spinal cord injury
a new 3d geometrical modelisation of adolescent idiopathic scoliosis and conception of a personal brace

Conditions: Scoliosis

Summary: adolescent idiopathic scoliosis (ais) involves complex tridimensional deformities of the spine. in case of progressive curve deformity, the use of spinal bracing remains the standard non operative treatment of moderate ais. most of the time, the different types of braces don't take into account the individual biomechanical properties of each patient's spine. actually, it is essential to better understand the effect of the loads applied on the trunk and on the spine, and a 3d geometrical modelisation of these components is essential. many studies have been publishing concerning the use of radiographs for the geometrical reconstruction of the spine, and more recently the eos system. but even then, it is still necessary to obtain an important number of geometrical data and discretisation is still a long procedure.


Eligibility criteria:
inclusion criteria: * age ≥ 12 years * pre menarchial for the girls * risser 0 et risser 3 on x rays. radiologic classification of spine maturity (ossification of the iliac crests). five stages. * cobb angle ≥25° and \< 40° * information to the parents and child, and signed approval exclusion criteria: * no idiopathic scoliosis * previous brace treatment * immediate indication for surgery * previous thoracic surgery
exercise therapy in head and neck squamous cell carcinoma (hnscc)

Conditions: Head and Neck Squamous Cell Carcinoma HNSCC

Summary: the goals of this clinical trial are to learn 1. determine the feasibility of a home-based exercise analog therapy using transcutaneous electrical nerve stimulation (tens), 2. determine the effects of exercise analog therapy on muscle mass, strength, and clinical outcomes, and 3. determine the effects of exercise analog therapy on immune phenotype and inflammation response in patients undergoing radiation for head and neck squamous cell carcinoma (hnscc). the main question it aims to answer are: does an exercise regimen using an analog tens unit during the course of cancer treatment for those with hnscc improve muscle mass, strength, clinical outcomes and immune response compared to those that do not perform the exercise regimen during their cancer treatment? researchers will compare outcomes of patients undergoing cancer treatment + tens unit exercise to those being treated for their cancer with no exercise tens unit. in the exercise arm, subjects will use the tens unit for 30 minutes of exercise a day, 3 times a week for the extent of their cancer treatments. weekly check-ins by phone or less frequently at scheduled in person visits. participants will keep a log of their exercise sessions to make sure that the exercise occurs 3 times a week for 30 minutes each and note any reasons why a session may have been missed or time shortened. both arms will have a blood draw at the beginning of their cancer treatment and approximately 4 weeks after the last cancer treatment (\~40ml). these samples will be tested for molecules that signal a higher or lower immune response with the addition of the exercise in one group compared to the cancer therapy only group.


Eligibility criteria:
inclusion criteria: * adult patients (18 years or older) * diagnosed with head and neck squamous cell carcinoma * hpv negative * undergoing treatment at olol h\&n center exclusion criteria: * any subject less than 18 years of age. * subjects who have hpv positive hnscc * subjects who have a pacemaker or electronic implant

Keywords: exercise therapy tens unit therapy exercise and cancer exercise and immune response
doc utility: screening of depression, obstructive sleep apnea and cognitive impairment

Conditions: Stroke; Transient Ischemic Attack; Depression; Obstructive Sleep Apnea; Cognitive Impairment

Summary: the primary objective of this study is to determine whether baseline doc screening can add to clinical and demographic data to predict the occurrence of a composite negative outcome (any of: recurrent stroke, myocardial infarction, death, or admission to a long-term care (ltc) / complex continuing care (ccc) facility) within one year of screening, in stroke prevention clinic patients.

the doc screen will be routinely applied to all patients presenting to three high volume regional stroke prevention clinics (combined first visits \>2,800 patients per year). data will be abstracted from the patient chart using methodologies developed and validated in the registry of the ontario stroke network. the investigators have reb approval to collect this data and to link with administrative datasets through the institute for clinical and evaluative sciences (ices). the investigators will use regression models to determine whether doc screen scores add to baseline clinical and demographic data to predict the main negative outcomes. the investigators hope to identify which patients presenting to tia/stroke prevention clinics are at highest risk of adverse long-term events so focused interventions can be developed to improve survival, outcomes and function of stroke prevention clinic patients.

Eligibility criteria:
inclusion criteria: * consecutive patients referred to regional stroke prevention clinics. * this includes those discharged from hospital with a diagnosis of stroke or tia, as well as emergency department referrals. * the doc crf will also be completed for patients who are unable to complete the screen due to severe aphasia, severe motor dysfunction and language barriers (those who are not fluent in english without translation available). exclusion criteria: * patients whose reason for referral to the clinic is neither stroke nor tia, as well as those who have been admitted to ltc/ccc facilities at the time of clinic visit.
pediatric feeding disorder evolution in amiens university hospital

Conditions: Feeding Disorders; Eating Behaviors; Dysphagia; Nutritional Status; Malnutrition; Children

Summary: pediatric feeding disorders (pfdss) affect children with age-inappropriate oral intakes lasting at least 2 weeks, associated with medical, nutritional, psychosocial or feeding skills dysfunction. feeding is a complex function involving the digestive tract, and different structures. it evolves throughout the child's development. it involves the caregiver-child relationship. dysfunction of one or more of these systems may be the cause of pediatric feeding disorders. pfds affect 25% of children, 5% with severe forms. pfds can have severe nutritional consequences. they often cause malnutrition, even undernutrition, and sometimes overweight.


Eligibility criteria:
inclusion criteria: * children \<18 years old * with at least two pediatric gastroenterology pfds consultations at chuap , * with an inapropriate oral intakes for at least 2 weeks, * association with medical, nutritional, psychosocial or eating-skills dysfunction. exclusion criteria: * anorexia nervosa

Keywords: feeding disorders eating behavior dysphagia nutritional status malnutrition artificial nutrition children
comparison of two techniques for the treatment of carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: the main objective of this study is to compare the complete section of the transverse carpal ligament with another median nerve release technique and to determine if the incidence of post-surgical pillar pain is lower for either of the two surgical techniques. as secondary objectives, we also seek to determine if the postsurgical grip and pincer strength and the boston carpal tunnel questionnaire (bctq) score are better for either of the two surgical techniques.

it will be a randomized clinical trial with a sample size of about 80 patients. it will have two study groups: the experimental group (in which 40 patients will be included) where a z-plasty technique will be applied; and the control group (another 40 patients) who will undergo the conventional technique of complete section of the transverse carpal ligament. the main variable will be the presence or absence of post-surgical pillar pain and, as secondary variables, the recovery of grip and pincer strength and the improvement in the bctq score will be studied. the study population will be patients with carpal tunnel syndrome diagnosed clinically (pain and paresthesias in the first three fingers and radial edge of the fourth finger, nocturnal paresthesias, thenar muscle atrophy, loss of thumb opposition), examination (durkan's signs , phalen and tinnel positive) and with a positive electromyogram test classified as "moderate" or "severe". as inclusion criteria, patients \>18 years of age with moderate-severe carpal tunnel syndrome whose symptoms hinder the daily activities of the patient and who have failed conservative treatment will be considered. those who have already undergone a previous surgical intervention for carpal tunnel syndrome in the same hand, who have traumatic or congenital sequelae in the hand or who do not have the capacity to understand the process or the tests to be performed will be excluded. the total expected duration of each patient in the study will be 6 months and the following visits and procedures will be carried out: clinical study and quality questionnaires prior to surgery and post-surgical follow-up at 3-4 weeks and at 6 months in consultation, with repetition of clinical examination and quality questionnaires. the incidence of pillar pain (defined as pain/sensation of allodynia in the area of the thenar and/or hypothenar eminence, hyperalgesia in the scar, pain when supporting the heel of the hand, dysesthesia at rest) will be analyzed applying the principle of intention to treat, using the mann whitney test to compare the score in the tests used.

Eligibility criteria:
inclusion criteria: * age \> 18 years * moderate-severe carpal tunnel syndrome * symptoms that hinder the patient's daily activities * correct conservative treatment without success exclusion criteria: * previous surgical intervention for carpal tunnel syndrome * traumatic or congenital sequelae of the hand * incompetence to understand the process and the tests to be carried out

Keywords: carpal tunnel syndrome pillar pain grip strength pincer strength
a study of arry-371797 in patients with osteoarthritis of the knee

Conditions: Osteoarthritis of the Knee

Summary: this is a phase 2 study, involving a 4-week treatment period, designed to test the ability of investigational study drug arry-371797 to reduce pain in patients with moderate to severe pain due to osteoarthritis (oa) of the knee, and to further evaluate the drug's safety. approximately 150 patients from the us will be enrolled in this study.


Eligibility criteria:
key inclusion criteria: * diagnosis of oa of the knee, based on american college of rheumatology (acr) criteria, confirmed by x-ray (k-l grade ii/iii within the last year). * at least moderate or severe pain due to oa in one knee. * on nonsteroidal anti-inflammatory drug (nsaid) 28 days previous to study start and willing to continue on nsaid throughout study. * discontinuation of opioids prior to study start. * additional criteria exist. key exclusion criteria: * current or recent infection in the last 7 days; infection requiring hospitalization or parenteral antibiotics within the last 6 months; history of or currently active tuberculosis, hepatitis b or c, or human immunodeficiency virus (hiv). * surgery on the index knee within the previous 6 months. * trauma or other surgeries within the previous 8 weeks. * specific abnormal laboratory values or electrocardiogram abnormalities. * gastrointestinal surgery that may interfere with motility or absorption. * on non-stable dose of bisphosphonates, or any prior denosumab or parathyroid hormone (pth) therapies. * prior parenteral tumor necrosis factor (tnf) inhibitor or anti-nerve growth factor (ngf) therapies. * intramuscular, intravenous or oral corticosteroids within the previous 6 weeks. * intra-articular corticosteroids in the index knee within the previous 8 weeks or viscosupplementation in the index knee within the previous 4 months. * currently enrolled in or participated in another clinical trial within the previous 3 months. * additional criteria exist.

Keywords: osteoarthritis knee pain nsaid
modula modul 7 vrr

Conditions: Atrial Fibrillation

Summary: this study will look at the correlation between ventricular rate regulation (vrr) and the percentage of biventricular pacing as well as subjective quality of life and level of physical ability in crt patients with atrial fibrillation.

to investigate whether vrr can increase the amount of biventricular pacing in crt patients with conducted atrial arrhythmias. secondarily, an investigation will be carried out to determine whether this increase in biventricular pacing results in an improvement in quality of life, as well as an improvement in the symptoms caused by the atrial arrhythmia and an improvement in the level of physical ability.

Eligibility criteria:
inclusion criteria: * patients with crt system with the vrr algorithm * patients with permanent atrial fibrillation * occasional conducted atrial fibrillation resulting in ventricular rates \> 70 beats per minute (bpm) * qrs complex \> 120 ms exclusion criteria: * patients with third degree atrioventricular (av) block

Keywords: heart failure
possibility to stop perdialytic heparin therapy in hemodialysed patients with hepran ™ membrane and treated by long-term anticoagulation with vka

Conditions: Chronic Hemolysis; VKA; Anticoagulants / Administration & Dosage; Coated Materials; Biocompatible; Heparin / Administration & Dosage; Membranes Artificial; Prospective Studies; Renal Dialysis / Methods; Renal Insufficiency / Therapy

Summary: use hepran ™ membrane (coated with heparin) should be allow the success of dialysis sessions, with adequate dialysis parameters, in patients treated by long-term anticoagulation with vka, without addition of heparin perdialytic. less use of heparin (ufh or lmwh) during hemodialysis session should be allow a decrease of bleedings (moderate or major) and blood transfusions for hemodialysed patients with hepran ™ membrane and treated by long-term anticoagulation with vka

the aim will be to study possibility of hemodialysis sessions success, without perdialytic anticoagulation but with adequate dialysis parameters (defined by the patient's kt / v machine), in patients treated by long-term anticoagulation with vka and dialysed with the hepran ™ membrane.

Eligibility criteria:
inclusion criteria : * 18 years old and older * chronic hemodialysis for at least 3 months * treated by long-term anticoagulation with vka * hemodialysis with the hepran® membrane * per dialytic heparin therapy (ufh or lmwh) * dialyzed at reims university hospital * agreeing to participate in the study exclusion criteria * chronic hemodialysis without per dialytic heparin * patient dialized with single lumen catheter for vascular access * less than 18 years old * pregnant or lactating women * protected by law