Kornimate/medical-research-clean huggingface dataset:
effectiveness of progressive muscle relaxation on sleep disturbance in athletes

Conditions: Sleep Disturbance in Athletes

Summary: literature supports that athletes have so many reasons for sleep disturbance in their day to day practice and during competition. this study is aimed to build familiarity with the significance of sleep for greatest athletic execution as well as providing progressoive muscle relaxation(pmr),(a technique proposed by jackobson to improve sleep and degrease the anxiety) as strategy to improve sleep prior to a significant competition during tournament

adequate sleep is necessary to accomplish ideal athletic performance, cognitive functioning and overall well-being. inadequate sleep is likewise connected to slow reaction time, delayed perception which can prompt impaired performance and increase risk of injury. a few investigations on sleep and athlete performance have additionally shown that sleep quality can be disturb for so many reasons. a range of interventions are available that may be beneficial or are commonly utilized in athletes to enhance sleep quantity and quality in athletes. drug strategies and hypnotics are related with side effects, for example, drug resistance and withdrawal symptoms. thus, there has been increase in utilization of non-drug strategies for further developing sleep quality. among such strategies are relaxation methods. it has been considered as one of the cost effective and simple methods for easing sleep. progressive muscle relaxation (pmr) is a method that involved efficiently relaxing global muscles of body with the objective of mental and physical relaxation. pmr is widely used previously to improve sleep in general population however there is currently no evidence to support pmr to improve sleep quality during a competition/tournament as a non-pharmacological method to improve participating athlete's sleep. the aim of this study is to build familiarity with the significance of sleep for greatest athletic execution as well as providing pmr as strategy to improve sleep prior to a significant competition during tournament.

Eligibility criteria:
inclusion criteria: participants falling in this category would be recruited into the study. * active athletes who are training for a competition. * age between 18 -36 years. * athletes score falling above 4 on "athletic sleep screening questionnaire" exclusion criteria: participant failing to fall in this category would be excluded of the study. * athletes who are not performing for more than a year. * history of metabolic diseases. * athletes taking sleeping aids i.e. sleeping pills. * having acute injury
role of hemostatic powder (endo-clottm) in prevention of bleeding within high risk patients after esd

Conditions: Iatrogenic Ulcer After ESD

Summary: sd has become a standard treatment of gastric neoplasm confined to mucosa(epithelium). but after procedure, formation of iatrogenic gastric ulcer is inevitable. and post esd ulcer bleeding rate reported about 5% \~ 10% of all cases. antiplatelet or anti-coagulation treatment might be associated higher incidence of rebleeding after esd and iatrogenic ulcer bigger than 40mm in size is also associated. though several previous study have failed to show efficacy of 2nd look egd, but those reports pointed out that visible vessels with current bleeding or highly suspect of recent bleeding (forrest type ia\~iib) was observed about 10\~20% of patients. such patients are at high risk of bleeding. so, investigators hypothesize that appliance of endo-clot(tm) at post esd ulcer have a significant role of protection from gastric acidic juice and help mucosa heal earlier. thus visible vessels with risk of bleeding is going to be rarely observed at 2nd look egd. and finally this protective effect might have an effect for prophylaxis of post esd ulcer bleeding.


Eligibility criteria:
inclusion criteria: a. older than 19 years old and younger than 80 years old b. pathologically confirmed gastric adenoma and/or early gastric cancer c. iatrogenic gastric ulcer after esd(endoscopic submucosal dissection) more than 40mm (at prediction) d. patients who is taking medication such at aspirin and/or coumadin (and other anti-coagulation medication) e. ecog performance status 0 or 1 f. adequate renal function (serum creatinine \< 1.5 mg/dl or calculated creatinine clearance ≥ 60 ml/min) g. adequate liver function (total bilirubin \< 1.5 x the upper limits of normal (uln), ast and alt \<3 x unl, and alkaline phosphatases \< 3 x uln or \< 5 x uln in case of liver involvement) h. adequate bm function (wbc ≥ 3,500/µl, absolute neutrophil cell count ≥ 1,500 /µl, platelet count ≥ 100,000/µl) i. subjects who given written informed consent after being given a full description of the study exclusion criteria: a. previously treated by radical gastrectomy b. adverse effect on this medication c. pregnant or on breast feeding d. patients who are unwilling or unable to provide informed consent, such as those with psychiatric problem, drug abuse or alcoholism

Keywords: post esd ulcer bleeding prophylaxis
the effect of insoles in plantar fasciitis

Conditions: Plantar Fasciitis

Summary: it aims to investigate the effect of two personalized insoles made of different materials designed to reduce pain in individuals with plantar fasciitis on muscle activation and gait parameters at 3-month follow-up.

plantar fasciitis (pf) occurs after inflammation and thickening of the fascia, which originates from the medial tuberosity of the calcaneus and runs in the medial plantar part of the foot and has a thick fibrous band structure. it aims to investigate the effect of two personalized insoles made of different materials designed to reduce pain in individuals with plantar fasciitis on muscle activation and gait parameters at 3-month follow-up. the participants of the study will consist of male and female individuals between the ages of 18-65 who are diagnosed with plantar fasciitis by a specialist doctor, who apply to the prosthetic orthotics center (pomer) with a personalized insoles prescription, and who volunteer to participate in the study.participants will be provided with demographic information, foot function assessment, pedobarographic analysis, gait assessment, muscle activity assessment, and satisfaction assessment. the foot function index (ffi) will be used to assess foot function in individuals with plantar fasciitis. foot plantar pressure distribution analysis will be performed using the tekscan software of the escoscan® pedobarographic assessment device. the plantar pressure analysis and physical evaluation of the individual will be performed and produced by computer aided design and computer aided manufacturing (cad-cam) method. muscle activation data will be recorded with biosignalsplux researcher kit brand emg device. satisfaction assessment-orthotic prosthesis users questionnaire (opka-m) will be used. sensory evaluation will be evaluated with semmes weinstein monoflaments. all data will be evaluated by statistical analysis methods.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-65, * being diagnosed with plantar fasciitis, * being prescribed custom insoles, * having complaints for at least 3 months, * heel pain complaint is at the plantar medial calcaneal tubercle, * pain complaint is most evident in the first steps taken in the morning or in the steps after resting, * having a roles and maudsley score of 3 or 4 in the initial evaluation exclusion criteria: * having a body mass index greater than 30 kg/m2, * having any cardiopulmonary, dermatological, neurological or orthopedic problems other than plantar fasciitis, * having a history of foot or ankle surgery, * using an assistive device (walker, canadiens, etc.) * not using appropriate shoes, * having cognitive, mental and/or psychological problems * being pregnant

Keywords: plantar fasciitis insole eva 3d printer muscle activation
bacterial epidemiology and empirical antibiotherapy in patients with prosthetic joint infection

Conditions: Joint Infection

Summary: the purpose of this study is to establish a bacterial epidemiology in patients who present a prosthetic joint infection and for which a surgery is necessary. at the time of the first surgery, as the bacteria responsible for the infection are not known, a probabilistic antibiotherapy is initiated at once after the surgical treatment. the antibiotherapy is then adapted to the bacteria from samples collected during the surgery when they are identified (the delay is 14-21 days). the study will focus on bacteria identified on samples collected during the surgery; the delay between the implantation of the prosthesis and the presentation of symptoms will be considered : more than one year vs. less than one year. investigators assume that there is not the same type of bacteria involved in those two cases of delays and that the probabilistic antibiotherapy may be not optimal when the symptoms are presented more than one year after implantation of the prosthesis. a probabilistic antibiotherapy not adapted lead to develop resistance for the bacteria and decrease the chance to cure the patient (increasing of relapse). the result of this study will allow medical doctors to have an optimal probabilistic antibiotherapy, depending on the delay between implantation of the prosthesis and the presentation of the symptoms.


Eligibility criteria:
inclusion criteria: * patient with prosthetic joint infection and treated with probabilistic antibiotherapy, between 2010 and 2015, at the croix-rousse hospital exclusion criteria: * none

Keywords: probabilistic antibiotherapy prosthetic joint infection treatment failure
early adiposity rebound amongst 4-y.o. children and overweight risk amongst 11-y.o children : third phase of a cohort study in franche-comté

Conditions: Childhood Obesity

Summary: this study aims to assess different methods for early adiposity rebound determination at the age of 4/5 years old according to current medical screening criteria in schools, and to assess their prognostic value for obesity amongst 11 years old pre-adolescents according to the known risk factors.


Eligibility criteria:
inclusion criteria: * boys and girls born between 1st july 2003 and 30th june 2004 * attending school in haute-saône * enrolled in the 2008 cohort survey exclusion criteria: * children whose parents refused to take part in this cohort study.
optimal standard treatment selection for solid tumor patients by biologically-informed multi-agent system

Conditions: Advanced Solid Tumors

Summary: this study is an exploratory cohort study conducted under real-world conditions, aiming to evaluate the feasibility of an artificial intelligence (ai)-guided standard treatment selection model for advanced solid tumors, as well as its superiority compared to clinician-selected treatment plans. a multi-agent system based on multimodal ai models will rank the priority of standard treatment options based on the personalized information of the patients, including including demographics, clinical information, and multi-omics data. the final treatment plan will be jointly selected by the patient and the clinician from the ai-recommended options, thereby delivering a personalized treatment.

this study is an exploratory cohort study conducted under real-world conditions, aiming to evaluate the feasibility of an artificial intelligence (ai)-guided standard treatment selection model for advanced solid tumors, as well as its superiority compared to clinician-selected treatment plans. the study will prospectively collect patient data of multiple dimensions, including demographics, clinical information (pathological classification, tumor staging, imaging findings, previous treatment regimens and their effectiveness, performance status scores), and multi-omics data (dna gene panel testing, whole-exome sequencing, transcriptome sequencing, etc.). a multi-agent system based on multimodal ai models will rank the priority of standard treatment options based on the personalized information of the patients. the final treatment plan will be jointly selected by the patient and the clinician from the ai-recommended options, thereby delivering a personalized treatment.

Eligibility criteria:
inclusion criteria: * voluntarily participate in the clinical study, fully understand and be informed about the study, sign the informed consent form, and be willing and able to comply with and complete all trial procedures. * aged ≥18 years, no gender restrictions. * patients with advanced or metastatic malignant tumors confirmed by histology or cytology. * able to provide tumor tissue and peripheral blood samples for multi-omics testing, or able to provide qualified whole-exome sequencing and transcriptomics data. exclusion criteria: * as assessed by the investigator, no standard treatment is available, or the patient is unsuitable for guideline-recommended anti-tumor therapies. * other conditions deemed unsuitable for participation in this study by the investigator.

Keywords: artificial intelligence real world study advanced solid tumors standard treatment multi-omics
phase ii trial of stereotactic radiation therapy (srt) versus srt plus vertebral augmentation procedure (vap) for vertebral metastasis

Conditions: Vertebral Metastasis

Summary: the purpose of this study is to determine pain control rate (percentage of patients in each arm that achieve pain control) at the treated site(s) at 1 month, 2-4 months and 5-6 months post-treatment.

eligible vertebral metastatic lesion/s-\> randomized-\> srt versus srt+ vap stereotactic radiation therapy(srt): 16 gy x 1 evaluation: prior to treatment; 1 month, 2-4 months, 5-6 months and 1 year post-treatment

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years. 2. ecog performance status 0-1. 3. known histologically proven malignancy. 4. localized osteolytic spine metastases from t7 to l5 demonstrated by mri, ct, pet or bone scan: a solitary spine metastasis; two separate spine levels; or up to 3 separate sites (each site may have a maximal involvement of 2 contiguous vertebral bodies with or without a paraspinal mass of no more than 5 cm). 5. negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potential. 6. women of childbearing potential and male participants who are sexually active must agree to use a medically effective means of birth control. 7. numerical rating pain scale (nrps) and movement-related pain score(mrps) within two (2) weeks prior to registration. 8. the patient must have a score of ≥ 5 for at least one of the planned sites for srt. 9. patients must provide study specific informed consent prior to study entry. 10. required pre-treatment evaluations: baseline numerical rating pain scale (nrps), movement-related pain score, dose and frequency of all pain medications; qol measure using the oswestry disability questionnaire, and euroqol(eq-5d). exclusion criteria: 1. non-ambulatory patients. 2. frank spinal cord compression or epidural compression within 3 mm of the spinal cord. 3. osteoblastic vertebral metastasis. 4. prior radiation to the index spine. 5. patients with rapid neurologic decline.

Keywords: vertebral metastasis pain control vap srt+vap
evaluation of elisa assay on human papilloma viruses (hpv) infection population

Conditions: Patient With Invasive Cervical Carcinoma; Patient With CIN Lesion; Patient With HPV Infected Patients Without Histopathologic Lesion; Normal Populations.

Summary: cervical cancer the most frequent neoplasm and the fifth mortality rate of malignancies of the women in the world. it results in about 1,000 women in taiwan and about 200,000 women worldwide dying of cervical cancer each year. human papilloma viruses (hpv) have been consistently implicated in causing cervical cancer especially those high-risk types (hpv 16,18,31,45) have been strongly associated with cervical cancer. around 50-80 % of women are infected by hpv within their whole lives. however, only 1% of hpv-infected women have cervical cancer eventually. seventy and 91% of hpv infection could be cleaned up by host immune responses within 1 and 2 years later. it shows that host immunity plays an important role in the progression, persistence, or regression of hpv infection. there are two main defense lines in the host immunity including innate immunity and adoptive immunity. adoptive immunity plays more important roles in the defense of hpv infections than innate immunity. the adoptive immunity could be further divided into humoral immunity and cell-mediated immunity. humoral immunity regulated by th2 helper t lymphocytes to generate memory b cells to produce antibody which provide the protective function to hpv infection. cell-mediated immunity regulated by th1 helper t lymphocytes to induce antigen-specific cytotoxic t cells which could kill the hpv-infected cells. although there are many researches focused on the immunity to hpv infection, there is no conclusion about the relationship between humoral and cell-mediated immunities on hpv infection and roles of humoral and cell-mediated immunities in the prognosis of hpv-infected population and cervical cancer patients. our research team has focused on the establishment of platforms on cell-mediated immunity to hpv infection and on the correlation of cell-mediated immunity and prognosis of hpv-infected population and cervical cancer patients for years. in order to survey the host immunity to hpv infection more comprehensively, we propose this proposal. first, we would like to set up the platforms to elucidate the humoral immunity to hpv infection in normal population and patients with cin lesion or cervical cancer. second, we would to survey the correlation betweem humoral immunity and status and clinico-pathologic items of hpv-infected populations. our research results will have a more comprehensive overview in the host immunity to hpv infection and its related diseases. it could provide more information in the prevention and treatment of hpv infection in the future.


Eligibility criteria:
inclusion criteria: * healthy volunteers * people infected with hpv type 16 but without cin lesions * patients with cin lesions * patients with cervical cancer from national taiwan university hospital * informed consent is obtained, and the protocols are reviewed and approved by the appropriate investigative review boards
two-year surveillance of rotavirus genotypes causing acute diarrhea in children younger than 5 years requiring emergency room (er) and hospital admission in chile

Conditions: Acute Diarrheal Disease; Rotavirus Infection

Summary: the purpose of this study is to prospectively determine the rotavirus vp7/vp4 genotypes associated with moderate to severe disease (requiring emergency room (er) consult or hospitalization) in a large public hospital from valparaiso and another from santiago.

rotavirus is the leading cause of gastroenteritis in children. our group has developed a surveillance system for acute rotavirus diarrhea in two large hospitals in chile since 2006. patients visiting the er for acute non-bloody diarrhea will be enrolled after an informed consent is signed by parents. a fresh stool sample will be collected to prospectively determine the rotavirus vp7/vp4 genotypes associated with moderate to severe disease (requiring emergency room (er) consult or hospitalization. stool samples will be tested for rotavirus by elisa ideia - rotavirus - oxoid. rotavirus positive samples will be genotyped as described previously (iturriza-gomara et al. j. clinical virol 2004). overall medical visits and hospitalizations, proportion of visits and hospitalizations caused by acute diarrhea, estimated numbers of rotavirus visits and hospitalizations will be calculated for each site. proportion of rotavirus vp7 and vp4 genotypes will be calculated for three month periods per center. differences in proportion will be compared by chi square and fischer's exact test when appropriate.

Eligibility criteria:
inclusion criteria: * children with acute diarrhea * children younger than 5 years exclusion criteria: * illiterate parents * chronic gastrointestinal disease

Keywords: diarrhea rotavirus genotype vp4 vp7
impact of parathyroidectomy on renal function

Conditions: Primary Hyperparathyroidism

Summary: primary hyperparathyroidism (phpt) is a disorder of one or more of the parathyroid glands. the parathyroid gland(s) becomes overactive and secretes excess amounts of parathyroid hormone (pth). as a result, the blood calcium rises to a level that is higher than normal. phpt is associated with several other metabolic complications as osteoporosis, kidney stones, hypertension, insulin resistance, cardiac calcifications, cardiac arrhythmias, and kidney failure. renal function deterioration over time has also been reported. however, the role of parathyroidectomy on renal function remains controversial in patients with phpt. in some studies, surgical cure of phpt has been shown to halt renal function deterioration in patients with coexisting renal disease. on the other hand, other studies showed no significant impact of parathyroidectomy on renal function. consequently, the goal of this study was to evaluate renal function before and after parathyroidectomy in a large cohort of patients with phpt.

primary hyperparathyroidism (phpt) is a disorder of one or more of the parathyroid glands. the parathyroid gland(s) becomes overactive and secretes excess amounts of parathyroid hormone (pth). as a result, the blood calcium rises to a level that is higher than normal. phpt is associated with several other metabolic complications as osteoporosis, kidney stones, hypertension, insulin resistance, cardiac calcifications, cardiac arrhythmias, and kidney failure. renal function deterioration over time has also been reported. however, the role of parathyroidectomy on renal function remains controversial in patients with phpt. in some studies, surgical cure of phpt has been shown to halt renal function deterioration in patients with coexisting renal disease. on the other hand, other studies showed no significant impact of parathyroidectomy on renal function. consequently, the goal of this study was to evaluate renal function before and after parathyroidectomy in a large cohort of patients with phpt. criteria are detailled in "outcomes measures"

Eligibility criteria:
inclusion criteria: - patients undergoing parathyroidectomy for primary hyperparathyroidism with surgical cure defined as postoperative normocalciemia exclusion criteria: * patients on dialysis * gfr \< 15 ml/min * renal graft

Keywords: primary hyperparathyroidism renal function