Kornimate/medical-research-clean huggingface dataset:
mechanisms in heart failure with normal ef

Conditions: Heart Failure

Summary: the guiding hypotheses are that (1) mechanisms in addition to diastolic dysfunction, while normal at rest, are compromised with stress, leading to symptoms of hf, and (2) that an increased proportion of the increase in lv diastolic pressures seen in hfpef is mediated via exaggerated pericardial/right heart-lv coupling (restraint).

nearly half of all patients with heart failure have a preserved ejection fraction (hfpef)1-3. this group is increasing in prevalence, has similar morbidity and mortality to systolic hf, and, despite increasing awareness of the healthcare burden, is without proven treatments1. this is related largely to a limited understanding of the basic mechanisms causing the disease3. recent studies have added to contemporary understanding, but the pathophysiology remains controversial and incompletely understood4-8. a limitation of most prior studies is that the noninvasive measurements employed are merely surrogates for gold standard, invasive hemodynamic assessment9. there is general consensus that hfpef patients have increased left ventricular filling pressures (lvdp) and relatively normal systolic function at rest5,8,10, but two critical questions remain: what causes the increase in lvdp, and, are there important deficits in the cardiovascular response to exercise stress in hfpef patients3,4? the current study will resolve these questions by performing comprehensive hemodynamic analysis in hfpef patients referred to the cardiac cath lab, compared to age and gender matched controls without hf. lv systolic, diastolic, and vascular function will be examined at rest and during graded supine exercise at fixed and varied preload to definitively characterize both baseline differences and discrepancies in cardiovascular reserve function that only become apparent during stress, when hfpef patients typically become symptomatic11. this study will yield valuable information describing the roles for systolic, diastolic and pericardial abnormalities in the pathogenesis of hfpef, providing critical preliminary data upon which better targeted therapeutic trials of this common disorder can be based.

Eligibility criteria:
inclusion criteria: * age\>18, ef≥50% at echocardiography within 6 months, referred for cath. hfpef subjects exclusion criteria: * patients with: any medical conditions that would limit study participation, pregnancy, myocardial infarction within 30 days of enrollment, hemodynamically significant valvular disease, hf due to thyroid disease, myocarditis, restrictive or hypertrophic cardiomyopathy, cor pulmonale (pvr\>5 wood units with rv dysfunction), lv thrombus, atrial fibrillation or other persistent irregular rhythm, dyspnea felt predominantly due to pulmonary disease, significant coronary artery stenoses (\>70%, or 50-70% with ffr\<0.8) or other abnormalities detected during the clinical catheterization procedure which require revascularization or other directed therapy.

Keywords: heart failure heart failure, diastolic stroke volume
covid-19 testing and vaccination among spanish speakers

Conditions: COVID-19; Vaccinations

Summary: latinx communities are disproportionately affected by the covid-19 pandemic, with spanish-speaking latinx communities carrying even heavier burdens of infection, hospitalization, and mortality. major barriers to covid-19 testing and vaccination exist, and a profound need remains to understand and address the social, ethical, and behavioral implications (sebi) of covid-19 testing and vaccination within latinx communities. our community-academic partnership proposes a rigorous mixed-methods, community-based participatory research study to better understand the sebi of covid-19 testing and vaccination and to refine and test a novel and culturally congruent intervention that integrates two evidenced-based strategies - peer navigation and mhealth - to increase covid-19 testing and vaccination within spanish-speaking latinx communities.

a profound need remains to understand the social, ethical, and behavioral implications (sebi) of covid-19 testing and vaccination interventions within spanish-speaking latinx communities. the proposal is a conceptually integrated community-based participatory research (cbpr) study that includes systematic data collection on the multilevel factors that influence covid-19 testing and vaccination; refinement of an efficacious intervention that uses complementary theory-based strategies (i.e., peer navigation and mhealth); intervention implementation and evaluation using a longitudinal group-randomized trial design; and dissemination of findings.

Eligibility criteria:
inclusion criteria: to be eligible to participate in the in the nuestrasaludsegura intervention as a navegante: * participant must self-identify as hispanic/latinx * participant must be spanish speaking * participant reports having been vaccinated against covid-19 * participant must be ≥18 years of age * participant must provide informed consent inclusion criteria: to be eligible to participate in the interviews as a social network member: * participant must self-identify as hispanic/latinx * participant must be spanish speaking * participant must be ≥ 18 years of age * participant must provide informed consent exclusion criteria: * less than 18 years of age

Keywords: covid-19 vaccinations spanish-speaking latinx hispanic/latino populations
a study examining adolescents with non-suicidal self-injury

Conditions: Self-Injurious Behavior; Deliberate Self-Harm

Summary: this study will examine longitudinal brain development in young adolescent girls with a history of non-suicidal self-injury (nssi). specifically, three constructs outlined by the the research domains criteria (rdoc) will be examined through self-assessment, mri, and a cognitive battery.

this study is designed to study brain development in 12-14 year old females with a history of nssi. assessments will take place over the course of three years, with three visits per year - a total of nine visits. the first visit will take place at the ambulatory research center (arc) at the fairview riverside hospital complex. this visit will include a number of questionnaires designed to gather information about the participant's physical and psychological health. additionally, measures of intelligence quotient (iq) and demographics will be assessed. the second visit will again take place at the arc. for this visit, participants will be asked to partake in the trier social stress test (tsst) in which they prepare a short, five-minute speech and deliver the speech to an audience with an additional task to follow. the tsst will be videotaped. following the completion of this task, the participant will complete computer tests in order to measure things like attention and memory. during the second visit, five saliva samples will be collected to measure levels of the hormone cortisol. the participant will need to collect additional saliva samples at home. the third visit will take place at the university of minnesota center for magnetic resonance research (cmrr) and will involve a brain mri. before the mri the participant will be asked to provide a urine sample and complete a drug and pregnancy test. during the mri, the participant will be asked to lie quietly in the scanner. the participant will do activities such as resting, listening to music, and playing games using a button box while in the scanner. the participant will need to come in to complete these assessments twice more at one and two years following the completion of the first set of visits - a total of nine visits overall.

Eligibility criteria:
inclusion criteria: * 12-16 years old * female * has had first menstruation * willingness to have de-identified data shared with rdoc database inclusion criteria - adolescents with non-suicidal self-injury: * any history of self harm inclusion criteria - healthy controls: * no history of self harm exclusion criteria: * male * pregnancy * mri incompatibility * iq of less than 80 * major medical illness * diagnosis of any of the following: primary psychotic disorder, bipolar spectrum disorder, autism spectrum disorder, current or past substance use disorder

Keywords: anxiety depression
glycaemic control effect of bsg and underlying gut - related mechanism in singapore adults with metabolic syndrome

Conditions: Metabolic Syndrome; Diabetes

Summary: the purpose of this research project is to assess the glycaemic controlling effects of consuming bsg and bio-transformed bsg-containing biscuits and its underlying gut - related mechanism in adults with mets using in-vivo setting.

this is a double-blind, randomised, parallel experiment, all subjects (38 adults in singapore with mets) will complete a 12-week intervention period. subjects will be randomly assigned to consume their habitual diet with biscuit that either does not contain or contains autoclaved bsg or bio-transformed bsg for 12 weeks. throughout the intervention, subjects will be assessed for glucose, insulin, lipid and amino acid responses, biomarkers of gut health, and as well as other markers of health.

Eligibility criteria:
inclusion criteria: * male and female participants, aged 35-85 years old * english-literate and able to give informed consent in english * willing to follow the study procedures * meet any 3 of the 5 following ncep-atp iii mets criteria: waist circumference \> 102 cm (male), \> 88 cm (female) (for asian population: waist circumference \> 90 cm (male), \> 80 cm (female)); fasting glucose concentration ≥ 100 mg/dl or on medication; triglyceride ≥ 150 mg/dl or on medication; high density lipoprotein cholesterol (hdl) \ 130/85 mmhg or on medication); exclusion criteria: * significant change in weight (≥ 3 kg body weight) during the past 3 months * allergy to barley, wheat, corn, egg, or other ingredients found inside the biscuits. * acute illness at the study baseline * exercising vigorously\* over the past 3 months. \*defined as having \> 6 metabolic equivalents of exercise daily; approximately 20 mins of moderate intensity exercise (e.g. slow jogging) a day * following any restricted diet (e.g. vegetarian) * smoking * have a daily intake of more than 2 alcoholic drinks per day * taking dietary supplements or food which may impact the outcome of interests (e.g. fermented foods, probiotic supplement etc.) * consumption of antibiotics over past 3 months. * pregnant, lactating, or planning pregnancy in the next 6 months * insufficient venous access to allow the blood collection * prescribed and taking antihypertensive/cholesterol-lowering/ type-2 diabetic medication which started less than 3 years prior to the intervention participation * high current intake of fibre\* from brown rice or wholemeal products. \*high, moderate or low intake taken as ≥ 6 servings, 4 - 5 servings, and ≤ 3 servings daily respectively based on my healthy plate guidelines * high current intake of fibre\* from vegetables. \* high, moderate or low intake taken as ≥ 2 servings, 2 servings, and ≤ 1 serving respectively based on my healthy plate guidelines

Keywords: metabolic syndrome middle-aged and older adults post-prandial glycaemic response bio-transformed food
paired associative stimulation in methamphetamine addiction

Conditions: Methamphetamine-dependence

Summary: the investigators use paired associative stimulation (pas) protocols to target cortico-cortical and cortico-subcortical networks to study cognitive deficits in methamphetamine addiction.

paired associative stimulation (pas) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses, producing long-term potentiation (ltp) or long-term depression (ltd) effect. the investigators use paired associative stimulation (pas) protocols to target cortico-cortical and cortico-subcortical networks (frontoparietal control pathway) by using different intervals between the paired pulses to explore the mechanism of cognitive deficits in methamphetamine addiction. the investigators hypothesize that different temporal sequences of cortical stimulation could produce facilitation or inhibition effect.

Eligibility criteria:
inclusion criteria: * in accordance with the diagnostic and statistical manual of mental disorders-5 (dsm-5) for methamphetamine (ma) use disorders * junior high school degree or above * normal vision and hearing * dextromanual exclusion criteria: * have a disease that affect cognitive function such as history of head injury, cerebrovascular disease, epilepsy, etc * have cognitive-promoting drugs in the last 6 months * other substance abuse or dependence in recent five years (except nicotine) * mental impairment, intelligence quotient (iq) \< 70 * mental disorders * physical disease

Keywords: paired associative stimulation frontoparietal pathway transcranial magnetic stimulation cognitive function
optimizing football training: integrating portable force plates for advanced performance analysis

Conditions: Injury;Sports

Summary: optimizing football training at multan sports complex: integrating portable force plates for advanced performance analysis," aims to enhance football training through innovative technology. under the supervision of dr. junaid gondal, this ms rehabilitation science project explores the use of portable force plates to provide real-time data on players' biomechanics, enabling personalized training programs that improve performance and reduce injury risks.

the research adopts a randomized control trial design, involving 30 male football players aged 18-35. participants are divided into intervention and control groups, with the former using portable force plates during training. data analysis will be conducted using ibm spss. this study underscores the significance of advanced performance analysis in football training, advocating for the integration of cutting-edge technology to refine training methods and enhance athletic performance at the multan sports complex.

Eligibility criteria:
inclusion criteria: * male football players at multan sports complex * aged 18-35 * willing to consent. exclusion criteria: * female players * unregistered players * those with unstable medical conditions.
comparison of corneal incision versus toric intraocular lens techniques used in cataract surgery

Conditions: Cataract Surgery

Summary: eyesight and quality of life improves in patients after refractive cataract surgery because this surgery treats myopia, hyperopia and presbyopia except astigmatism. in order to make a patient spectacle free ophthalmologists use different methods during cataract surgery to minimize astigmatism.

these methods includes limbal relaxing incisions (lris) or the insertion of toric iols, which are specifically intended to cancel out pre-existing astigmatism and astigmatic keratometry. this research will be conducted to see which method benefits more for treating preoperative astigmatism in eye.

Eligibility criteria:
inclusion criteria: * both genders were included. * patients having astigmatism was included. patients having cataract was included. * eyes having no other ocular pathology was included. * patients having no history of corneal scar was included exclusion criteria: * eyes having any ocular pathology will be excluded. * patients with corneal suture will be excluded. * those using contact lenses instead of spectacles for vision correction will be excluded. * participants with a history of eye surgery within the past year will be excluded.
phase 3 open-label extension trial with rotigotine in idiopathic restless legs syndrome subjects

Conditions: Idiopathic Restless Legs Syndrome

Summary: this is a multicenter, open-label trial to assess safety and tolerability of rotigotine in subjects with idiopathic restless legs syndrome (rls), administered at an optimal dose for up to 1 year in subjects who previously participated in sp790 (6-month pivotal trial) or sp794 (sleep lab trial). subjects who successfully completed the maintenance period and the taper period of sp790 or sp794 are allowed to enroll in this trial.


Eligibility criteria:
inclusion criteria: * subject completed the maintenance period and taper period of sp790 or sp794 exclusion criteria: * subject has an ongoing serious adverse event (sae) from sp790 or sp794 that is assessed to be related to the trial medication by the investigator and/or the sponsor. * subject has any medical or psychiatric condition that, in the opinion of the investigator, can jeopardize or would compromise the subject's ability to participate in this trial

Keywords: rotigotine restless legs syndrome
telephone calls for health for homebound older adults

Conditions: Loneliness; Social Isolation; Depression

Summary: a randomized controlled trial of the effect of 4 weeks of regular check-in calls, up to 5 per week based on participant's choice and 2 survey collection calls and possible referral of other services, versus no daily check-in calls, on self-reported loneliness measures for current meals on wheels participants (mow).

the intervention arm will include 125 mow clients to receive a call of between 5 - 10 minutes in length each by a consistent caller, five times a week, monday through friday for 4 consecutive weeks to check in on them. after the first week of calls, subjects in the intervention arm will be asked if the frequency of calls is acceptable or if they would like to reduce the call frequency, potentially to a minimum of twice per week. brief guidance and training will be provided for the daily conversation to maximize time spent speaking by the recipient but otherwise, the calls are unscripted other than specific prompts to ask about the recipient's general sense of well-being. "how are you doing today?" the control arm will include 125 mow clients who will be randomized to a control group that will not receive the intervention calls. the control group will receive calls from a member of the research team at the beginning of the study to collect baseline survey data and at the post-4-week period to collect post-study survey data.

Eligibility criteria:
inclusion criteria: * adult (18+) clients of meals on wheels of central texas exclusion criteria: * cognitive impairment or in a hospice program.
asociación española de gastroenterologia (spanish gastroenterology association) gastroesophageal reflux disease guideline - prospective study

Conditions: GERD

Summary: to evaluate symptomatic outcome and hrqol in gerd patients treated following a new cp guideline.


Eligibility criteria:
inclusion criteria: * signed informed consent * age above 18 * subjects with typical gerd symptoms: predominant heartburn/regurgitation * naive patients or off ppi treatment in the last 2 months exclusion criteria: * inability to read and understand pro instructions * patient not suitable to be treated following the aeg guidelines * concomitant treatment with nsaid, antiplatelet drugs * previous ppi failure

Keywords: gerd clinical guideline symptoms clinical outcome
the study of anesthesia-related risk factors for postoperative death in elderly non-cardiac surgery patients in china

Conditions: Postoperative Mortality; Anesthesia; Elderly Patients; Noncardiac Surgery

Summary: at present, the elderly population in china has reached 241 million, and there are more than 20 million elderly surgical patients every year, accounting for about 25% of the surgical population. however, there is no research report on the anesthesia related risk factors of death of elderly patients in hospital. the purpose of this study is to analyze the perioperative data of multicenter database, and to explore the anesthesia related death risk factors of elderly patients with noncardiac surgery in the investigator's country, especially within 24 hours after surgery, so as to help improve the anesthesia management technology of elderly patients during surgery, improve the medical quality of perioperative period, and improve the prognosis of patients.


Eligibility criteria:
inclusion criteria: * 1.patients larger than 65 years old at the time of surgery 2.patients hospitalized for surgery between jua 2008 to april 2020 exclusion criteria: - 1.critical demographic information and course records are inaccurate or missing. 2.the outcome could not be determined during the hospitalization. 3.cardiac surgery patients 4.patients undergoing surgery under local anesthesia
dryvax dilution-prev vacc adults

Conditions: Smallpox

Summary: a double-blind, randomized, dose-response study of four dilutions of dryvax in previously vaccinated adults in order to assess the clinical success rates, humoral responses, and virus-specific actifity of cytotoxi t cells and interferon-y producing t cells


Eligibility criteria:
inclusion criteria: * for cohort e (never vaccinated): aged 18-31; never been vaccinated for smallpox. * if female, not pregnant or lactating. * promise to use an effective method of birth control for 7 months after vaccination. * negative result on a test for hiv, aids, hepatitis b and c. * acceptable as blood donors. * for cohorts a, b, c, d (previously vaccinated): aged 32 to 60 years; known history of smallpox vaccination with a typical vaccinia scar; no smallpox vaccination after 1971. * healthy adults (aged 18-60). exclusion criteria: * eczema or history of eczema, or other chronic skin disorder. * pregnancy or lactation. * history of immunodeficiency, liver disease, severe kidney impairment, malignancy, hiv, hepatitis b, or hepatitis c. * household contact with persons who are under 12 months of age, pregnant or lactating, or have any of the specified diseases.
lanreotide autogel and pegvisomant combination therapy in acromegalic patients

Conditions: Acromegaly

Summary: the main aim of this study is to assess the efficacy of the co-administration of lanreotide autogel 120 mg (administered via deep sub-cutaneous injections every 28 days) and pegvisomant (administered at 40 to 120 mg per week via sub-cutaneous injection given once or twice a week) on igf-1 levels over 28 weeks in acromegalic patients. the primary endpoint will be the percentage of acromegalic patients with normalised (age and sex adjusted) igf-1 level at the end of the co-treatment period.


Eligibility criteria:
inclusion criteria: * the patient must have had documentation supporting the diagnosis of acromegaly, including elevated gh and/or igf-1 levels * the patient is treated with pegvisomant, because of igf-1 level remaining above uln when treated with somatostatin analogue, on a daily basis for at least 3 months and has normal (age and sex adjusted) igf-1 level, or igf-1 level above the upper limit of normal (uln) after treatment with pegvisomant 30 mg per day, or the patient is treated with lanreotide autogel or octreotide lar for at least 6 months including 3 months at the highest marketed dose and has a serum igf-1 level above uln, 28 days after the last injection * at the end of the run-in period, the patient has a serum igf-1 level above 1.2 x uln, or a serum igf-1 level between uln and 1.2 x uln and a serum gh nadir \> 1 µg/l (assessed by an ogtt), 28 days after the 3rd injection of lanreotide autogel 120 mg or the patient is diabetic and has a serum igf-1 level above 1.2 uln, 28 days after the 3rd injection of lanreotide autogel 120 mg exclusion criteria: * the patient has undergone pituitary surgery or radiotherapy within 6 months prior to study entry, or it is anticipated that it will be done during the study * the patient has already been treated with a somatostatin analogue associated with a gh antagonist * the patient has received dopamine agonist within 6 weeks prior to the study entry * the patient has abnormal hepatic function at study entry (defined as ast, alt, ggt, alkaline phosphatase, prothrombin time or total bilirubin above 2 uln) * the patient is at risk of pregnancy or is lactating