Kornimate/medical-research-clean huggingface dataset:
improving memory in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: people with multiple sclerosis (ms) suffer from cognitive and other brain problems. this study will examine the effectiveness of the drug donepezil and of sugar water for enhancing memory in individuals with ms. donepezil (also known as aricept) has been fda approved for improving memory and learning in individuals with alzheimer's disease.

cognitive dysfunction is one of the leading causes of disability in people with ms. memory involving specific words (verbal memory) is particularly affected in individuals with ms. attempts to rehabilitate cognitive dysfunction in ms have had only limited success. this study will determine the efficacy of donepezil therapy and glucose administration for enhancing verbal memory functioning in individuals with ms. the study will also measure secondary outcomes assessing other areas of cognitive dysfunction (i.e., nonverbal memory, conceptual thinking, processing speed) which may improve with intervention. forty participants with ms will be randomly assigned to receive either donepezil or placebo for 24 weeks. participants will complete memory and cognitive tests at the beginning and end of the 24 week period. twenty participants with ms will be randomly assigned to drink a beverage sweetened with either glucose or saccharin (placebo). participants will then complete memory and other cognitive tests. two weeks later, participants will drink a beverage sweetened with the alternative sweetener and again complete the memory and cognitive tests.

Eligibility criteria:
inclusion criteria * ms as defined by the poser criteria * expanded disability status scale (edss) score of 0 to 6.5 * stable neurologic function for at least 30 days prior to study entry * agree to continue all current medications for study duration * rey auditory verbal learning test score in low normal range or below * mini-mental status exam score of 26 or higher * montgomery-asberg depression scale scaled score of 14 or lower * fluent in english exclusion criteria * use of anticholinergic or benzodiazepine medication * change in dosage of medications judged to have the potential to impact cognitive function (e.g., antispasticity medications) within 2 weeks of study entry * current alcohol or substance abuse * history of neurological or major medical problem that has a known effect on cognitive functioning * history of noncompliance * visual or upper extremity impairment which precludes ability to participate in cognitive assessment

Keywords: multiple sclerosis cognitive dysfunction treatment interventions verbal memory deficits
socio-psychological factors involved in the hematopoietic stem cell transplantation process in people with hemopathies

Conditions: Leukemia

Summary: identify the psychological factors (i.e. personality and transactional factors), beneficial and deleterious, at different phases of the transplant process, on the patient's mental health (quality of life, short and long-term post-transplant recovery) and physical health (e.g. infections, relapse, length of hospitalization or even death).

to reach the research purposes, questionnaires will be given to patients at different times during the transplant process : 1. pre-admission transplant questionnaire: given and collected by the transplant physician during the pre-graft consultation before entering hospitalization (approximatively 15 days before). to be completed by the patient on site (approximately 45 minutes to complete the questionnaire) 2. transplant admission questionnaire: given during the first days of hospitalization. to be completed within 6 days and returned to the transplant physician (approximately 30 minutes to complete the questionnaire) 3. post-transplant follow-up questionnaire: given in consultation at 6 months by the transplant physician (between 30 and 45 minutes to complete the questionnaire in consultation) the questionnaires include validated and standardized scales. the first questionnaire contains scales on dispositional factors (i.e. personality factors) . the second one is on the so-called transactional adjustment factors. and the third is on post-transplant factors (e. g. post-traumatic growth). scales from the first and second questionnaire will be used to obtain a longitudinal view. the study population concerns all patients going to receive an allograft transplantation, aged over 18 years, who have consented to answer the various questionnaires over a period of approximately 7 months . the participants come from the hematology departments of the saint-louis hospital in paris, the estaing university hospital in clermont-ferrand and the brabois hospital in nancy.

Eligibility criteria:
inclusion criteria: * patient with hematopathy with allograft hsc indication * allograft protocol * patient over 18 years of age * patient who has read and understood the information note and who has consented has not objected to participating in the research * patient affiliated to a social security system (beneficiary ) exclusion criteria: * patients receiving autograft * patient under 18 years of age * patient under guardianship or curatorship
weight loss via bariatric surgery and lifestyle modification

Conditions: Obesity; Weight Loss

Summary: gastric myoelectric, inflammatory, and hormonal responses, body compositional, energy expenditure, and metabolic changes during the development of obesity and the weight loss process are underinvestigated. this project studied the myoelectrical inflammatory and hormonal responses of the stomach, in addition to energy expenditure and body composition changes during weight loss via bariatric surgery and lifestyle intervention.

gastric myoelectric, inflammatory, and hormonal responses, body compositional, energy expenditure, and metabolic changes during the development of obesity and the weight loss process are underinvestigated. this project studied the myoelectrical, inflammatory, and hormonal responses of the stomach, in addition to energy expenditure and body composition changes during weight loss via bariatric surgery and lifestyle intervention. methods: we recruited 79 participants who were assigned to three groups: bariatric surgery (bs group n=27), lifestyle intervention (ls group, n=22), and waitlist control (c group n=30). for all participants, electrogastrography, inflammatory cytokines, gastric hormones analysis, body composition analysis, energy expenditure, and dietary assessment were done at baseline and at 6 months.

Eligibility criteria:
inclusion criteria: * bmi \> 35 kg/m2, * being free of any acute medical condition, inflammatory conditions, malignancy, or psychiatric disorders exclusion criteria: * taking weight-losing pharmacotherapy * who underwent previous bariatric surgery

Keywords: gastric myoelectric activity inflammatory bariatric surgery lifestyle intervention weight loss body composition
effect of radiofrequency of suprascapular nerve in shoulder reverse arthroplasty

Conditions: Rotator Cuff Tear Arthropathy; Post Operative Pain

Summary: the purpuse of this study is to asses if the pulsed radiofrecuency of the supraescapular nerve and accesory nerve have the same or superior efectivity controlling the acute postoperative pain than interscalenic braquial plexus block

this is a randomized, double-blind trial that compares the effect in postoperative pain of pulsed radiofrecuency of the supraescapular nerve carried out at least two to four weeks before reverse total shoulder arthroplasty surgery with interscalenic braquial plexus block done at the moment of the surgery. all the patients received conventional general anaesthesia and multimodal postoperative analgesia with additional patient-controlled rescue analgesics were prescribed

Eligibility criteria:
inclusion criteria: * over 18 y.o. * cronic pain (more than 3 months) due to rotator cuff arthropathy * vas higher than 4 * decrease constant score * conservative treatment (physiotherapy and nsais) unsuccessful exclusion criteria: * psychiatric illness * drug abuse. * previous surgeries. * acute traumatic pathology or ethiology different from rotator cuff arthropathy * pacemaker * infectious process

Keywords: rotator cuff arthropathy reverse shoulder arthroplasty supraescapular nerve radiofrecuency post operative pain
acute ischemic apoplexy syndrome specificity and acupuncture intervention research

Conditions: Acute Ischemia

Summary: this project optimizes the tcm symptoms and symptoms scale. a curative effect evaluation system of acupuncture in the treatment of acute ischemic stroke is formed to provide clinical evidence by the following indexes: neurological impairment, motor dysfunction, tcm symptoms and symptoms scale, combined with the patients' head mri, plasma bdnf, mmp-9 and other biomarkers.

based on the previous work, this project optimizes the tcm symptoms and symptoms scale. through the cohort study method, 194 patients with acute ischemic stroke were evaluated for neurological impairment, motor dysfunction, tcm symptoms and symptoms scale, combined with the patients' head mri. , plasma bdnf, mmp-9 and other biomarkers, screen tcm syndromes related to stroke outcome indicators, and adopt targeted comprehensive acupuncture and moxibustion program intervention and follow-up to establish a stroke-specific intervention outcome prediction model with tcm characteristics. a curative effect evaluation system of acupuncture and moxibustion in the treatment of acute ischemic stroke is formed to provide clinical evidence.

Eligibility criteria:
inclusion criteria: * (1) it meets the diagnostic criteria in the "chinese guidelines for the diagnosis and treatment of acute ischemic stroke 2014"; with the support of brain ct or mri imaging examination, the vital signs are stable, the state of consciousness is clear, and the gcs\>8 points; （2）.onset is less than 2 weeks; （3）. there is no indication for thrombolysis, or the patient do not accept thrombolysis; （4）. for moderate to severe patients, the national institute of health stroke scale (nihss) ≥ 4 points;（5）.glasgow coma standard (gcs)\>7 points;（6）.no serious disability before admission, and modified rankin scale (mrs) ≤ 3;（7）. the patient himself or his immediate family members signed the informed consent form. exclusion criteria: - (1) cerebral hemorrhage or subarachnoid hemorrhage; (2) cerebellar and brainstem infarction (including lacunar infarction); (3) cerebral herniation is formed upon admission; (4) patients with severe heart, lung, liver, and kidney diseases; (5) severe upper gastrointestinal bleeding occurred after the onset; (6) the patient has participated in other clinical trials within the past 3 months; (7) patients with mental illness, or those with severe cognitive impairment (mmse score ≤9 points) (8) those with a pacemaker, a metal foreign body at the treatment site, or a severe bleeding tendency. (9) the investigator believes that other diseases accompanied by the patient may interfere with the correct evaluation of neurological function, or participating in this trial may cause other complications in the patient.
an intervention study to reduce drug-related problems and readmissions among old people with dementia

Conditions: Cognitive Impairment

Summary: the aim of this randomized controlled study is to investigate if medication reviews performed by a clinical pharmacist as part of a ward team can reduce drug related problems and reduce readmissions to hospital among elderly patients (≥65 years) with dementia and cognitive failure. four hundred and sixty patients will be recruited and randomized to control (usual care) and intervention group (enhanced service in which a pharmacist is part of the health care team). six months after the last patient of the 460 has been discharged the study will be closed. data about the number of readmissions and visits to the emergency room will be collected during the six-month follow-up and also, the costs associated with each visit or admission. time until institutionalization will be compared between intervention group and control group.


Eligibility criteria:
inclusion criteria: * patients with dementia or cognitive impairment * patients ≥ 65 years exclusion criteria: * patients previously admitted to the study wards during the study period

Keywords: drug related problems
probiotics in the treatment of irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: evidence have shown benefits of gut flora modulation in treatment of irritable bowel syndrome (ibs), but few reports are available on the effects of multistrain probiotics and there are few reports available in this regard from our society. thus, we investigated if probiotics are effective in our patients as well. we hypothesize that the multistrain probiotic balance containing seven bacteria species including lactobacillus strains, bifidobacterium strains, and streptococcus thermophiles reduces the symptoms of irritable bowel syndrome.


Eligibility criteria:
inclusion criteria: * age between 18 and 65 * diagnosis of ibs based on the rome iii criteria * willingness to participate exclusion criteria: * receiving other probiotics compound during the study * receiving antibiotics during the study

Keywords: irritable bowel syndrome functional gastrointestinal disorders gut flora probiotics
trial of pre-pregnancy supplements

Conditions: Anemia

Summary: the purpose of this study is to determine whether daily oral supplements of multivitamins (including vitamins b-complex, c and e) along with iron and folic acid given to non-pregnant women results in lower prevalence of anemia in preparation for pregnancy when compared to daily iron and folic acid supplements or folic acid alone.

globally, more than half a million women die from pregnancy or childbirth-related complications, most of them in developing countries. the global community committed to reducing the maternal mortality ratio by three quarters between 1990 and 2015 (mdg5). women die from a range of complications in pregnancy, childbirth or the postpartum period. 80% of maternal deaths are due to severe bleeding (mostly bleeding postpartum), infections, hypertensive disorders in pregnancy and obstructed labor. additionally, low birth weight and neonatal mortality are common problems in developing countries. the benefit of periconceptual folate on preventing congenital anomalies has been established in randomized trials; however, the role of other nutrients needs to be examined further. anemia is strongly associated with adverse perinatal outcomes including maternal mortality and low birthweight.

Eligibility criteria:
inclusion criteria: 1. girls aged \> =15 years and \<= 29 years 2. have not missed a menstrual period during recruitment (no amenorrhea) 3. has not been pregnant or given birth within the last 6 months 4. intend to stay in the study area for at least 6 months after enrollment 5. have provided written informed consent exclusion criteria: 1. amenorrhea or confirmed pregnancy at screening or enrollment. 2. has given birth within 6 months 3. already taking long-term vitamin supplementation. 4. any severe illness requiring hospitalization at screening or enrollment (women who have been deemed to have recovered will be eligible once they return home).

Keywords: multivitamins folate iron periconception
rotational stability and clinical response of the asqelio toric biaspheric monofocal lens.

Conditions: Cataract

Summary: the goal of this observational study is to evaluate the rotational stability and clinical performance of the asqelio toric lens in candidates for cataract surgery with asquelio toric intraocular lens (iol) implantation. information will be obtained from patients operated by routine clinical practice with toric monofocal asqelio iol in at least one eye. after confirmation of inclusion, the preoperative examination will be performed, and after surgery an evaluation will be performed the following day, one week, one month and three months after surgery.

in cataract surgery, the opacified lens is removed by phacoemulsification and replaced by an artificial iol.the most common risk of cataract surgery is the development of a condition called posterior capsular opacification (pco) that causes further deterioration of visual function. toric intraocular lenses correct corneal astigmatism and avoid residual refractive errors in these subjects. for their efficacy in this refractive error correction, it is essential that, once implanted, these lenses are rotationally stable.the goal of this observational study is to evaluate the rotational stability and clinical performance of the asqelio toric lens during the first 3 months after implantation. all patients participating in the study are candidates for cataract surgery with asquelio toric intraocular lens (iol) implantation model tlio130 from ast products, inc., with ce marking.

Eligibility criteria:
inclusion criteria: * subjects 22 years of age or older undergoing cataract surgery in at least 1 eye and implanted with lio asqelio. * subjects for whom postoperative emmetropia was planned (±0.5 d spherical equivalent) exclusion criteria: * preoperative corneal astigmatism less than 0.75d * patients who do not provide informed consent * patients who do not understand the study procedure. * previous corneal surgery or trauma. * irregular cornea (e.g. keratoconus). * microphthalmos. * severe corneal dystrophy. * pregnant or breastfeeding'. * rubella * mature/dense cataract making eye bottom preoperative examination difficult. * previous retinal detachment. * concurrent participation in other research with drugs or clinical devices. * expect to require another eye surgery during the study period.

Keywords: cataract
resuscitative endovascular balloon occlusion of the aorta in haemorrhagic shock

Conditions: Non-compressible Torso Hemorrhage; Trauma Injury

Summary: resuscitative endovascular balloon occlusion of the aorta (reboa) is a procedure that has the goal to stabilize trauma patients with non-compressible torso hemorrhage by temporarily occluding the aorta with a ballon catheter to increase central perfusion and stop uncontrollable bleeding from the diaphragm downwards. the investigators are planning to evaluate all patients who had a reboa catheter placed at their clinic or in the pre-clinical setting from the start of 2019 to the 31.12.2022 who were transferred to their clinic, with basic demographic and clinical data, the procedural specifics, and their potential complications.

resuscitative endovascular balloon occlusion of the aorta (reboa) is a procedure that has the goal stabilize trauma patients with non-compressible torso hemorrhage by temporarily occluding the aorta with a ballon catheter to increase central perfusion and stop uncontrollable bleeding from the diaphragm downwards. the investigators plan to evaluate all patients who had a reboa catheter placed at their clinic or in the pre-clinical setting from the start of 2019 to the 31.12.2022 who were transferred to their clinic, with basic demographic and clinical data, the procedural specifics, and their potential complications. investigators will search for patients who had a reboa catheter placed in the study period in the clinical documentation system (openmedocs) and the database of the german trauma registry. documentation will include hemodynamic parameters, transfused blood products, complications, basic demographics and mortality up to thirty days after reboa placement. the investigators will then try to find patients with similar trauma mechanism and severity of trauma in the german trauma registry and match them with their reboa patients.

Eligibility criteria:
inclusion criteria: * patient with non-compressible torso hemorrhage following major trauma with reboa placement * age\>18 years * reboa placement during the initial resuscitation exclusion criteria: * age\<18 years * missing data

Keywords: uncontrollable hemorrhage trauma ballon occlusion of the aorta
longitudinal (weekly) follow-up of active plaques in multiple sclerosis with 3 teslas multi-modality mri using diffusion, perfusion, venography and proton spectroscopy

Conditions: Lesions; Multiple Sclerosis

Summary: it is difficult to determinate prognostic criteria of multiple sclerosis with conventional mri insofar as physiopathology is not well-known: the precise sequences of events leading to plaque formation and axonal injury are still not completely understood. some elements involved in plaque formation can be studied thanks to mr techniques (cerebrospinal fluid and periveinular spaces, neuronal injury, microglia, and cerebral microcirculation's dysfunction). this study aims at giving a better understanding of ms plaques' physiopathology, using data from modern mri through a longitudinal followed up with weakly mr 3t examination.

the objective of this work are: * study weakly development of the active ms plaque with multimodal mri parameters using advanced mri techniques: veinography/3d flair, diffusion (cda), perfusion (cbv, cbf, mtt) mr spectroscopy (naa, myo-inositol, choline, lactate...) and enhanced 3dt1 sequences. * define prognostic markers of ms aggressiveness ("black holes") * study development of ms plaque around venous structures.

Eligibility criteria:
inclusion criteria: * age between 18 and 50 years. * health coverage. * any form of ms defined by mc donald's criteria (2005). * patients having shown an enhanced plaque on a less than six month mri examination. exclusion criteria: * patients with an immunomodulating therapy like natalizumab (tysabri) and intravenous immunosuppressive therapies. other therapies will not be excluded from this study. for patients treated by systemic corticotherapy, a one-month delay will be necessary before a mri examination. * cerebral microangiopathy (diabetes, arterial hypertension, vascularitis...) * patient with classical mri contraindication like pace-maker, cardiac valvulosis, claustrophobia, allergy to contrast agent ... * pregnancy or pregnancy desire. * patient with a low creatinine clearance \<60 ml/mn

Keywords: multiple sclerosis active plaque multimodal analysis 3t mri weekly follow-up physiopathology physiopathology of active lesions formation in multiple sclerosis using multimodal mr sequences