Kornimate/medical-research-clean huggingface dataset:
liver fat quantification by magnetic resonance imaging (mri) - prediction of postoperative complications

Conditions: Fatty Liver; Surgery

Summary: the purpose of this study is to objectively quantify liver fat content (lfc) by magnetic resonant imaging (mri) prior to major liver surgery, and to investigate its association with post-operative complications.

lack of agreement exists among expert pathologists in the standard histological assessment of hepatic steatosis on biopsy. the impact of different grades of steatosis on postoperative complications after major liver resection remains controversial.

Eligibility criteria:
inclusion criteria: * major liver resection (\>= 3 resected segments). * patients that received a pre-operative magnetic resonance imaging (mri). * patient over 18 years of age exclusion criteria: * patients that underwent liver surgery but \< 3 segments were resected (e.g. wedge liver resection). * patient that did not receive a pre-operative mri * patient age less than 18 years of age.

Keywords: fatty liver liver magnetic resonance imaging surgery
effects of app-based versus personal on-site instruction on neuromuscular activity in injury prevention exercises

Conditions: Musculoskeletal Injury; Injury, Knee

Summary: therefore, the aim of the present study was to evaluate neuromuscular characteristics observed during a single bout of selected and validated injury preventive exercises instructed by an app (in accordance with 'get set - train smarter') versus gold standard instruction, supervision and feedback provided on-site by an expert. the present evaluation targets a population of female football and handball players without any previous exposure to injury prevention training.


Eligibility criteria:
inclusion criteria: * female handball or football player (≥ 18 years old) competing at sub-elite level (i.e., 2-3 weekly training sessions) exclusion criteria: * previous traumatic knee injury, lower limb injury at the time of testing and/or previous engagement in injury prevention practices.
open-label study to evaluate the safety and tolerability of iv lacosamide in japanese adults with partial-onset seizures

Conditions: Epilepsy; Partial-onset Seizures

Summary: ep0024 is a phase 3, multicenter, open-label study to evaluate the safety and tolerability of intravenous (iv) lacosamide (lcm). adjunctive iv lcm therapy (200 mg/day to 400 mg/day) will be administered for 5 days as replacement for oral lcm tablets in japanese adults with partial-onset seizures.


Eligibility criteria:
inclusion criteria: * subject is japanese and enrolled in ep0009 (nct01832038) receiving oral lacosamide (lcm) for the treatment of partial-onset seizures and has been enrolled for at least 8 weeks * subject has been on a stable twice daily (bid) dosage regimen of lcm 200 mg/ day to 400 mg/ day, for the 2 weeks prior to entry into ep0024 * subject has been receiving no more than 3 concomitant antiepileptic drugs (aeds) at doses that have remained stable for the 2 weeks prior to entry into ep0024 exclusion criteria: * subject has a history of any kind of status epilepticus within 12-month period prior to study entry * subject has actual suicidal ideation as indicated by a positive response ("yes") to either question 4 or question 5 of the "since last visit" version of the columbia-suicide severity rating scale (c-ssrs)

Keywords: lacosamide lcm epilepsy partial-onset seizures iv
a study to evaluate the long-term safety and tolerability of lucerastat in adult subjects with fabry disease

Conditions: Fabry Disease

Summary: a study to determine the long-term safety and tolerability of oral lucerastat in adult subjects with fabry disease. this study includes a sub-study evaluating kidney gb3 inclusions (and other histologic lesions) in male participants with classic fabry disease who have been treated for at least 2 years with lucerastat monotherapy in study id-069a302.

study id-069a302 will continue at each site until lucerastat is commercially available in the respective country or until all subjects have reached month 24 (for subjects participating only in stage 1) or month 48 (for subjects participating in stages 1 and 2) or month 72 (for subjects participating in stages 1, 2 and 3), whichever is earliest.

Eligibility criteria:
inclusion criteria: * signed icf prior to any study-mandated procedure; * subject completed the 6-month, double-blind treatment period in study id 069a301 * woman of childbearing potential only if agreement 1) to follow a specified contraception scheme, 2) to undertake monthly urine pregnancy tests. * fertile male only if agreement 1) to use a condom, 2) to not father a child. exclusion criteria: * pregnant / planning to be become pregnant or lactating subject; * subject considered to be at high risk of developing clinical signs of organ involvement within the time period of the study, as per investigator judgment; * any known factor or disease that might interfere with treatment compliance, study conduct or interpretation of the results as per investigator judgment. in addition, the subject must not be enrolled in study id-069a302 if at any time during study id-069a301, one of the following criteria was met: * subject's egfr per the chronic kidney disease epidemiology collaboration creatinine equation \< 15 ml/min/1.73 m2; * subject experienced an event of acute kidney injury common terminology criteria for adverse event (ctcae) grade 2 or above; * subject experienced an event of stroke ctcae grade 3 or above; * subject experienced an event of heart failure leading to in-patient hospitalization or prolongation of ongoing hospitalization.
neuropsychiatric scleroderma study: systematic evaluation of neuropsychiatric involvement in systemic sclerosis

Conditions: Systemic Sclerosis

Summary: systemic sclerosis is a rare disease with vascular involvement and systemic fibrosis. this disease is usually thought to spare central nervous system. however, neuropsychiatric manifestations like depression and cognitive functions impairment seem to be frequent. pathophysiology of this neuropsychiatric manifestations is currently unknown. white matter hyperintensities have been reported suggested cns vascular manifestations in systemic sclerosis. whether this cns vascular involvement plays a role in neuropsychiatric manifestations in systemic sclerosis is unknown. the primary objective of this prospective and multicentre study is to assess a link between neuropsychiatric manifestations and cns involvement in systemic sclerosis. secondary objectives are to assess the frequency of neuropsychiatric manifestations, to compare central nervous system abnormality between scleroderma patient and healthy subjects. central nervous system involvement and neuropsychiatric manifestations will be systematically assessed through central nervous system imaging and questionnaires.


Eligibility criteria:
inclusion criteria: * male or female between 18 and 65 yo * with scleroderma (american college of rheumatology and/or leroy et medsger) * informed consent given exclusion criteria: * other auto-immune disease * non french native speakers * severe arterial hypertension * diabetes * anemia * renal insufficiency * cranial trauma * history of neurological disorder or neurotoxic treatment * pregnancy or breast feeding * impossibility or non compliance to perform the protocol flow chart * contra indications to mri

Keywords: systemic sclerosis neuropsychiatric manifestations magnetic resonance imaging
noninvasive determination of cerebral tissue oxygenation in pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: to study the effect of acute pulmonary vasodilatation on cerebral tissue oxygenation (cto) and cerebral blood flow (cbf) as indicator for cerebrovascular autoregulation in comparison to the effects of supplemental oxygen, decreased carbon dioxide by hyperventilation and exercise in patients with pulmonary hypertension (ph) undergoing clinically indicated right heart catheterisation (rhc). oxygenation and hemodynamic parameters will be assessed during rhc according to standard procedures. non-invasive near infrared spectroscopy (nirs) and a nasal canula will be additionally applied to measure cto, cbf and endtidal co2 (etco2). all parameters will be obtained at rest breathing room air, during an oxygen challenge, during standardized hyperventilation, under vasodilatation testing and during exercise in random, single-blinded sequences (except for exercise and hyperventilation). pulmonary, systemic and cerebral oxygenation parameters and hemodynamics will be correlated with each other and functional class, quality of life, exercise and cognitive assessments at the time of the rhc and after three month.


Eligibility criteria:
inclusion criteria: inclusion criteria are age 18 years or older, to be scheduled for rhc due to suspected or known ph and the ability to give informed consent. both genders will be accepted. exclusion criteria: exclusion criteria are: inability to follow the study due to language or cognitive problems (e.g. a major active psychiatric disorders, prior traumatic brain injury, and neurologic disease), dementia on the basis of a mini mental state test and pregnant women.

Keywords: pulmonary hypertension, nirs, near-infrared spectroscopy, cerebral tissue oxygenation, cerebral blood flow
correlation between blood biomarkers and postoperative delirium in elective non-cardiac surgery.

Conditions: Postoperative Delirium; Elective Non-Cardiac Surgery

Summary: more than 20% of patients over 60 years old develop postoperative delirium following non-cardiac surgery . delirium increases morbidity and mortality , and may lead to long-term cognitive impairment . the underlying mechanisms behind delirium are not understood , endothelial dysfunction and disruption of the blood brain barrier (bbb ) caused by perioperative systemic inflammation may play a important role in the development of delirium . this study intends to evaluate the relationship between neuroinflammation and postoperative delirium in elderly non-cardiac surgery patients . the results of the study are to identify risk factors and explore the biomarkers most closely linked to each step of the proposed pathway .

the investigators do the neuropsychological tests , mini-mental score examination (mmse ) , charlson comorbidity index (cci ) , quality of recovery score - 40 (qor-40 ) 1 day before the surgery（baseline ) . serum of the patients was collected before operation and at pod1 , and then detect the concentration change of biomarkers of endothelial dysfunction , blood brain barrier disruption and neuronal injury . also , the patients were interviewed once before discharge from pacu and twice on postoperative days 1-3 by the confusion assessment method and then divided them into pod and non-pod groups . meanwhile , the severity of pain (numerical rating scale（nrs )) was evaluated at the same time and qor-40 at 1 day after surgery .

Eligibility criteria:
inclusion criteria: 1. patients undergoing selective major noncardiac surgery and general anesthesia; 2. age 60-90 yrs; 3. anesthesia society of american (asa) scale ii\~iii; 4. anticipated surgery time 2-6 hrs 5. written informed consent; exclusion criteria: 1. decline to participate 2. dementia patients（mini-mental state examination\< 20） 3. factors existed that affect cognition assessment such as language,visual,and auditory dysfunction.

Keywords: delirium blood biomakers endothelial dysfunction blood brain barrier (bbb)
investigation of the effects of frailty and sarcopenia on postoperative recovery and complications in geriatric patients

Conditions: Frailty; Sarcopenia

Summary: after obtaining ethical approval, 42 patients with american society of anesthesiologists (asa) scores i-iii who were scheduled for surgery under general anesthesia were included in our prospective study. patients were monitored in the preoperative preparation room in the operating room and frailty was assessed using the frail scale and sarcopenia was assessed using the star ratio. the thickness of the rectus femoris and vastus intermedius muscles of the patients was measured and recorded by ultrasonography. thigh lengths were measured and recorded. rectus femoris/thigh length (rf/b), vastus intermedius/thigh length (vi/b), and total muscle thickness/thigh length (t/b) were calculated and recorded. patients were followed up according to the modified aldrete score after surgery in the anesthesia recovery unit, and the time to reach 9-10 points was recorded, and the time to leave the recovery unit was recorded. postoperatively, complications were followed up according to the clavien-dindo classification, and discharge times from the hospital were recorded.

frailty is a clinically identifiable state of heightened vulnerability resulting from age-related declines in physiological systems and functions, leading to impaired resilience to stressors. frailty is highly prevalent among the elderly and is associated with an increased risk of falls, disability, hospitalization, and mortality. magnetic resonance imaging (mri) and computed tomography (ct) are considered the gold standard for sarcopenia diagnosisct is also limited due to radiation exposure and similar logistical constraints. in contrast, ultrasonography (usg) is portable, cost-effective, and can be performed at the bedside without radiation exposure. using high-frequency ultrasound probes, peripheral muscle tissues and their dimensions can be rapidly assessed.

Eligibility criteria:
inclusion criteria: * patients over 60 years of age who are undergoing colorectal malignancy surgery under general anesthesia * patients willing to participate in the study * patients with asa score i-iii exclusion criteria: * patients with parkinson's disease, * alzheimer's disease, * history of cerebrovascular events, * neuromuscular disease, * cognitive dysfunction, * severe liver disease, * severe heart disease, * impaired cooperation due to kidney disease, * emergency and trauma patients, * patients with bilateral lower extremity amputations

Keywords: geriatric anesthesia sarcopenia ultrasonography postoperative complications quadriceps femoris
covid-19 pandemic and academic performance of veterinary students

Conditions: COVID-19

Summary: the study aims to analyze the effect of covid-19 pandemic on the academic performance of veterinary students, veterinarians, and researchers during the lockdown.


Eligibility criteria:
inclusion criteria: * veterinary students and researchers exclusion criteria: -
the roles of cytokines in the mechanism of insulin resistance and energy balance

Conditions: Metabolic Syndrome X; Cachexia; Insulin Resistance

Summary: insulin resistance and disturbances in energy homeostasis are associated with body weight changes, such as diabetes, hypertension, hyperlipidemia, obesity, cancer cachexia, aging, and acute or chronic infectious diseases. cytokines secreted by adipose tissue and inflammatory cells play important roles in the pathological conditions. several novel cytokines were disclosed recently, but their functions have not been well known. further investigation of these cytokines, resulting in insulin resistance and energy homeostasis, is very important to elucidate the mechanisms and develop new therapeutic strategies.

we are studying patients with body weight change, increased or decreased. healthy people are the control group. we are recording body weight, body height, and physical exam results. in addition, we are drawing peripheral blood for further biochemical and cytokine assays.

Eligibility criteria:
inclusion criteria: * insulin resistance condition

Keywords: metabolic syndrome
nasal bubble continuous positive airway pressure in reducing respiratory distress in children with bronchiolitis

Conditions: Bronchiolitis Acute Viral; Bronchiolitis; Bronchiolitis Acute; Bronchiolitis, Viral; Nasal Continuous Positive Airway Pressure

Summary: this study is designed to assess the effectiveness of nasal continuous positive airway pressure in reducing respiratory distress in children with bronchiolitis

in this study, after taking consent from caretakers, patients of brochiolitis will be randomly assigned to either a standard care group or a nasal continuous positive airway pressure group. both groups will be followed for respiratory distress. respiratory distress will be compared by using seattle sore of respiratory distress.

Eligibility criteria:
inclusion criteria: * children presenting with history of cough, and tachypnea and wheezing on clinical examination exclusion criteria: * patients needing mechanical ventilation at the time of admission * patients whose caretakers refuse written informed consent * patients having consolidation on chest x-ray
randomized double-blind placebo-controlled crab or shrimp allergy reduction study using nambudripad allergy elimination techniques

Conditions: Food Allergies

Summary: purpose of this study is to determine whether naet procedures are effective in the treatment of crab or shrimp allergy. hypothesis: experimental group will show a significant improvement over the control group in allergic symptom, serum crab- or shrimp-specific ige and skin test for crab or shrimp extract.

nambudripad allergy elimination techniques (naet) were developed by dr. devi nambudripad in 1983. many patients have been relieved of allergy and allergy-related disease by this treatment. lack of well-controlled clinical study prevents naet from being accepted as a treatment option in current medical system. the aim of this project is to conduct a double blind-placebo controlled study of applying naet to treat crab or shrimp allergy. the parameters to be measured are allergic symptom, crab- or shrimp-specific ige and skin test before and after naet treatment

Eligibility criteria:
inclusion criteria: * older or equal to 20 years old * history of allergic to crab or shrimp * positive serum crab- or shrimp-specific ige exclusion criteria: * history of anaphylactic shock * on medication of anti-histamine or steroid * pregnancy

Keywords: food allergies
a study of hospital-at-home for people receiving tarlatamab

Conditions: Small-cell Lung Cancer; Small Cell Lung Carcinoma

Summary: the purpose of this study is to find out whether a hospital-at-home (hah) program is a more efficient way to monitor people's health after receiving tarlatamab than monitoring in the hospital (inpatient).


Eligibility criteria:
inclusion criteria: patient * diagnosis of extensive stage small cell lung carcinoma (es-sclc) * treatment plan of commercially available tarlatamab monotherapy as standard of care * patients must be 18 years of age or older * eastern cooperative oncology group (ecog) performance status \<2 * patients must have adequate organ and bone marrow function, defined by the following laboratory results obtained within 28 days prior to the first study treatment: * anc ≥ 1000 cells/μl (without granulocyte colony stimulating factor support within 4 weeks prior to cycle 1, day 1) * platelet count ≥50,000/μl (without transfusion within 4 weeks prior to cycle 1, day 1) * hemoglobin ≥8.0 g/dl (without transfusion within 4 weeks prior to cycle 1, day 1) * alanine aminotransferase (alt), aspartate aminotransferase (ast) ≤ 3 x upper limit of normal (uln). serum bilirubin ≤ 1.5 x uln. patients with known gilbert disease who have serum bilirubin level ≤ 2 x uln may be enrolled. * estimated glomerular filtration rate (egfr) ≥ 30ml/min using the ckd-epi formula. * the patient is willing to give and sign informed consent * appropriate homebound setting as defined by one of the following: * lodging at msk residence or hotel * 5 new york city boroughs, lower westchester county (northern boundary cross county parkway) and nassau county (eastern boundary wantagh state parkway). this is based on the community paramedic (seniorcare) 60-minute response time catchment area. if there is any uncertainty about patient residence eligibility, the principal investigator will decide after discussion with seniorcare. * patients must be accompanied by a caregiver for the period of time the patient is enrolled in the hah intervention. for cases where there is uncertainty, the principal investigator will make the final determination. caregiver * primary caregiver as identified by patient enrolled on studyphysician * treating physician for patient(s) enrolled on study; managing treatment plan of commercially available tarlatamab as standard of care exclusion criteria: patient * patients with a documented active infection prior to starting tarlatamab. this includes grade 3 or higher viral, bacterial, or fungal infection. * patients with baseline dementia or cognitive barriers * uncontrolled arrhythmias caregiver * caregiver deemed inappropriate by treating physician physician * no exclusion criteria

Keywords: small-cell lung cancer small cell lung carcinoma tarlatamab memorial sloan kettering cancer center 25-077
4d-ct-based ventilation imaging for adaptive functional guidance in radiotherapy

Conditions: Lung Cancer

Summary: to develop and investigate a novel radiotherapy technique for preserving lung function based on a map of lung function.


Eligibility criteria:
inclusion criteria: * eligible disease(s)/stage(s) ajcc stage i, ii, iii or iv lung cancer of any histology to be treated using radiotherapy will be eligible for this study. note that we will carefully consider the inclusion of cases with turbulent flow or greater flow velocities (cabahug et al., 1996; crawford et al., 1990) and copd cases (magnant et al., 2006) due to the impaction of aerosol particles in central airways. * allowable type and amount of prior therapy. any types and amounts of prior therapy will be allowed for this study. * age restriction and/or gender/ethnic restrictions * patients must be greater than or equal to 18 years of age. * there are no gender or ethnic restrictions. * life expectancy restrictions - none. * ecog or karnofsky performance status * not employed. note that patients will need to be sufficiently healthy to undergo audiovisual (av) biofeedback to generate high quality 4d-ct images. * requirements for organ and marrow function none. * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: children (less than 18 years of age), pregnant women, stanford employees or students, or prisoners will be excluded from this study.
ilioinguinal nerve excision in open mesh repair of inguinal hernia,a randomized clinical trial

Conditions: Postoperative Pain; Postoperative Hyposthesia

Summary: this study was designed to evaluate the effect of routine excision of the ilioinguinal nerve in an attempt to decrease the incidence of chronic inguinodynia in patients who undergo open anterior hernia mesh repair.

as chronic pain is the 2nd most common complication following open hernia repairs and it causes limitations and dysfunctions for the patients and also according to some previous studies elective ilioinguinal neurectomy could result in less postoperative pain,we decided to perform a randomized double blind clinical trial.the primary goal of this study was evaluation of the effect of this type of neurectomy on postoperative pain and hyposthesia.

Eligibility criteria:
inclusion criteria: * having an age of over 18 years exclusion criteria: * those with diabetes, incarcerated, bilateral and recurrent hernias and visual problems were excluded from the investigation.

Keywords: inguinal hernia herniorrhaphy mesh repair ilioinguinal neurectomy postoperative pain in cases and controls during one year. postoperative hyposthesia in cases and controls during one year.