Kornimate/medical-research-clean huggingface dataset:
effect of hypnosis on dyspnea

Conditions: Healthy; Dyspnea

Summary: the purpose of this protocol is to test the effect of hypnosis on laboratory dyspnea.

this is a study of permissive suggestion in two laboratory models of dyspnea ("work/effort", "air hunger"). breathing discomfort rating induced by laboratory models of dyspnea will be assessed before, during and after hypnosis.

Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * pregnancy * ongoing pain * respiratory disease * high levels of depression, panic disorder, or other significant mental health problems * not fluent in french
physical activity intervention for improving vascular comorbidity risk in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: vascular comorbidities, such as high cholesterol, obesity, high blood pressure, and diabetes, are common among people with multiple sclerosis (ms), and can negatively impact disease diagnosis, treatment, and progression. physical inactivity may be one possible reason for this increased risk and may occur through changes in cardiorespiratory fitness (the ability of the body to transport and use oxygen during sustained physical activity). while exercise training is effective for improving fitness, factors such as accessibility to facilities and financial cost may not make it a viable option for most people with ms. an alternative approach for improving fitness is by increasing daily physical activity levels. the research team has developed and tested an internet-delivered lifestyle physical activity intervention that has been shown to improve physical activity levels among people with ms. this lifestyle intervention is a promising approach for also increasing fitness and managing vascular comorbidity risk in persons with ms. this randomized clinical trial will examine the efficacy of a 6-month lifestyle physical activity intervention on cardiorespiratory fitness and vascular comorbidity risk in persons with ms.


Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis * relapse-free in the past 30 days * stable course of disease modifying therapy over the past 6 months * being non-active, defined as not engaging in regular exercise (i.e., ≥30 minutes/day on \>2 days/week during the last 6 months) * internet access * ability to comprehend study materials and communicate in english * expanded disability status scale (edss) score \<6.0 * willingness to complete three testing sessions at the university of ottawa separated by 6 months * willing to undergo randomization to a lifestyle physical activity condition or general wellness condition for 6 months * intermediate risk level for cardiovascular disease based on the framingham cardiovascular disease risk score calculator * asymptomatic (i.e., no major signs or symptoms of acute or uncontrolled cardiovascular, metabolic, or renal disease; e.g., chest pain) based on the get active questionnaire and the health history section of the american heart association (aha)/american college of sports medicine (acsm) health/fitness facility pre-participation screening questionnaire * physician approval for participation exclusion criteria: * pregnancy * previous enrollment in lifestyle physical activity behaviour interventions

Keywords: exercise fitness co-morbidity
effect of sepsis response team in the emergency department

Conditions: Sepsis

Summary: does sepsis response team in the emergency department increase the portion of sepsis patient who receive adequate treatment within one hour?

does sepsis response team in the emergency department increase the portion of sepsis patient who receive adequate treatment within one hour? the time from the patients arrive at the emergency department to an adequate antibiotic is given, before and after introduction of a sepsis response team, was registered.

Eligibility criteria:
inclusion criteria: * patients with suspected sepsis exclusion criteria: * patients who was consider not to need antibiotics
evaluation of ventilatory strategies during laparoscopic surgery

Conditions: Pneumonia

Summary: atelectasis involving declive areas often occurs during general anesthesia and may persist postoperatively. this phenomenon could be amplified by pneumoperitoneum and trendelenburg position. hypothesis: to evaluate whether the shape of the airway pressure-time curve, stress index (si), during constant flow inflation can lead ventilator setting during general anesthesia.


Eligibility criteria:
inclusion criteria: * american society anesthesiology (asa) i, ii; * age \> 18 years; * elective surgery exclusion criteria: * asa iii, iv; * age \< 18 years; * emergency surgery

Keywords: atelectasis laparoscopic surgery anesthesia mechanical ventilation prevent shape of the airway pressure-time curve
efficacy of corrective rubber insoles in healthcare professionals with foot overpronation

Conditions: Hyperpronation; Overpronation; Pes Planus

Summary: foot hyperpronation is a common postural condition that can lead to pain, deformities (such as hallux valgus), and muscular issues. this problem is especially relevant among adults who spend long hours standing, such as healthcare workers. custom-made foot orthoses with a medial wedge have proven effective in improving comfort and correcting certain biomechanical alterations, even in asymptomatic individuals. the study described has two main objectives: * to validate the italian version of the foot health status questionnaire (fhsq), already validated in english and spanish, by assessing its reliability and reproducibility as a tool to measure foot health. * through a pilot study, to analyze the effects of using specific professional footwear in healthcare workers with hyperpronation, evaluating perceived benefits in terms of pain reduction and postural improvement.


Eligibility criteria:
inclusion criteria: * healthworker (attendings, residents, or nurses, er nurses, therapists...) * maximum age inferior to 65 y.o. at recruitment time * partecipants stands from 60% to 80% of their working time * uses mostly healthcare shoes while working * hyperpronation condition * no other pathologic condition of the feet * partecipants accept to wear medially wedged orthesis for at least 3 months * signatures of consensus to join the study * partecipants must be aware of the implication of the study exclusion criteria: * other pathologic condition of the foot * age superiore to 65 y.o. at the recruitment time
study to investigate the effect of a single dose of azd7624 on inflammation caused by an endotoxin challenge

Conditions: LPS Challenge, Neutrophils

Summary: study to investigate the effect of a single dose of azd7624 on inflammation caused by an endotoxin challenge.

this is a double-blind, randomised, placebo controlled, 2-way cross-over study to investigate the effects of a single dose of inhaled azd7624 on white blood cells and inflammatory markers in induced sputum and blood after oral inhalation of lps as well as the safety, tolerability and pharmacokinetics (pk) of azd7624 following a single inhaled dose.

Eligibility criteria:
inclusion criteria: 1. healthy male and/or female volunteers aged 18 to 55 years (inclusive) with suitable veins for cannulation or repeated venipuncture. (healthy as determined by medical history and physical examination, laboratory parameters, and ecg performed before the first administration of the ip) 2. female volunteers must have a negative pregnancy test at visit 1 and on admission (day -1 of visit 3 and visit 5) to the study centre, must not be lactating and must be of non childbearing potential 3. be able to produce a minimum of 100 mg sputum (pellet weight) of good quality with total cell count (defined as total cell count \<14 x 106/g, eosinophils \<3%, sputum neutrophil % differential \<65%, \<30% squamous cell contamination and a minimum of 50% ce 4. have normoresponsive airways with a methacholine pc20 \>16 mg/ml. screening methacholine provocation is not required if the volunteer has been tested by the centre in the past 1 year, with documented records of this testing 5. be able to inhale from spira nebuliser exclusion criteria: 1. history of any clinically important disease or disorder which, in the opinion of the investigator, may either put the volunteer at risk because of participation in the study, or influence the results or the volunteer's ability to participate 2. any infection within the previous 4 weeks. volunteers who get an infection between visit 1 and admission to the centre can be rescreened 3. history of severe allergy/hypersensitivity or ongoing clinically important allergy/hypersensitivity, as judged by the investigator or reason to expect untoward reactions to lps and/or azd7624 4. history of chronic respiratory disease 5. volunteers who are vegans or have medical dietary restrictions -

Keywords: healthy volunteers, phase 1
chronic ankle instability diagnostic tests determining underlying deficits

Conditions: Ankle Dislocation; Chronic Ankle Instability

Summary: chronic ankle instability is a common condition in the active adult population and characterized by the occurrence of repeated giving way and/or recurrent ankle sprains. multiple underlying deficits have been proposed, among which ankle muscle strength deficits, proprioception deficits, ( static and dynamic balance disorders, and articular laxity. unfortunately, no consensus exists on which clinical tests should be realized to determine if one of these underlying deficits is predominant and as a result could guide the rehabilitation process. the study hypothesis is that people with chronic ankle instability might be heterogenous and could be divided in different subgroups as a function of underlying deficits. therefore, this study aims to evaluate the capacity of different clinical tests to differentiate people with chronic ankle instability from healthy people as well as between each other.


Eligibility criteria:
inclusion criteria: * case subject : at least one initial lateral ankle sprain more than 12 months before inclusion * case subject : at least one residual symptom among (1) giving way, (2) sensation of instability, (3) recurrent ankle sprain. this item is confirmed by a score inferior than 24 on the chronic ankle instability tool (cait) * case subject : impact on activities of daily living and sport, confirmed by a score of less than 90% on the foot and ankle ability measure (faam) and less than 80% on faam-- - -- control subject : matched by age and sex to case subjects exclusion criteria: * surgery of one of the lower limbs less than 3 years ago * presence of heavy pain (eva \> 8) regardless of its origin * acute lateral ankle sprain less than 4 months before inclusion * neurological disorders of any kind * medical treatment (drugs) interfering with muscle tone, balance and proprioception disorders * pregnant or breastfeeding women * body mass index \> 30 * bilateral chronic ankle instability

Keywords: chronic instability strength proprioception rehabilitation ankle balance
dual antiplatelet therapy in patients with clopidogrel resistance following off-pump coronary artery bypass

Conditions: Multi Vessel Coronary Artery Disease

Summary: ticagrelor, a direct-acting oral p2y12-receptor antagonist, provides greater and more consistent platelet inhibition than clopidogrel. this study aimed to compare outcomes of ticagrelor plus aspirin versus clopidogrel plus aspirin 1 year after off-pump coronary artery bypass grafting (opcab) in patients with clopidogrel resistance.

between november 2014 and november 2020, 1739 patients underwent opcab. aspirin (100mg daily) and clopidogrel (75mg daily) were administered beginning at aday 1 after surgery. on the 7th postoperative day, the clopidogrel resistance was evaluated by point-of-care assay. among them, the patients had clopidogrel resistance were enrolled in this study. investigators divide them into two groups \[a: ticagrelor, b; clopidogrel\]. primary endpoint was all-cause of mortality 1 year after opcab. secondary endpoint included major adverse cardiovascular events (mace: cardiac death, myocardial infarction, or stroke). multivariate cox regression was used to evaluate predictors of end points.

Eligibility criteria:
inclusion criteria: 1. patients aged 19 years or older 2. undergoing elective opcab surgery with multi-vessel coronary artery disease. exclusion criteria: 1) patient had aspirin resistance

Keywords: antiplatelets coronary artery bypass surgery
comparison of mri versus three dimensional ultrasound in the diagnosis of mullerian duct anomalies

Conditions: Mullerian Duct Anomaly

Summary: mullerian duct anomalies (mdas) are relatively common disorders, with a prevalence estimated to be around 2% in the general population, and 6% to 7% in women with a history of recurrent pregnancy loss. mullerian duct anomalies are associated with recurrent pregnancy loss, intra uterine growth retardation, and preterm labor and birth. the prevalence of preterm birth and pregnancy loss varies with the type of mda. patients can benefit from surgery or hysteroscopic interventions like metroplasty based on the type of mda. therefore, to optimize patient outcomes, accurate diagnosis and description of mdas is essential. magnetic resonance imaging (mri) is an excellent way of evaluating the uterus for mdas. mri, although costly, is less expensive than laparoscopy and hysteroscopy and is non-invasive. pellerito et all evaluated 26 women with surgically proven mdas and found that in 24 cases mri was able to correctly diagnose the mdas. therefore mri is generally considered as a reference standard for uterine evaluation. in a study comparing mri and endovaginal two-dimensional ultrasound (2dus), mri appeared to be more accurate than 2dus with a sensitivity of 77%, specificity of 33%, and a positive predictive value of 83%. endovaginal three-dimensional ultrasound (3dus) is a relatively new technology that creates three-dimensional volumes from a series of two-dimensional images. this technique allows the user to acquire coronal or face-on-view of the uterus which is essential in evaluating the uterus for the presence of mdas. kupesic and kurjak used 3dus to evaluate 86 patients and found that it had sensitivity of 98.38%, specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 96% in the diagnosis of septate uteri \[7\]. endovaginal 3dus is less expensive, less invasive, and less-time consuming than hysteroscopy or mri and appears to be a very promising technology for the evaluation of mdas. 3dus appears to be at least as accurate as mri in the diagnosis of mdas. in addition, 3dus is less expensive than mri and in some patients better tolerated. if validated using prospective studies, 3dus has the potential to become the reference standard for the diagnosis of mdas.


Eligibility criteria:
inclusion criteria: 1. age ≥ 16 2. patients with suspected mullerian duct anomalies (history of recurrent miscarriage or history of primary or secondary infertility). 3. patients scheduled to undergo routine endovaginal or transabdominal ultrasonography and pelvic mri to evaluate possible mdas exclusion criteria: 1. age \< 16 2. general contraindications to mri such as pacemaker etc.

Keywords: mullerian duct anomaly 3-dimensional ultrasound magnetic resonance imaging
modified limberg procedure versus lateral advancement flap with burrow's triangle procedure in the treatment of pilonidal sinus

Conditions: Sacrococcygeal Pilonidal Disease

Summary: the investigators want to share our study that is the "comparison of modified limberg flap transposition and lateral advancement flap transposition with burrow's triangle in the surgical treatment of sacrococcygeal pilonidal sinus.

pilonidal sinus disease (psd) is a common and chronic entity of the young adults. so far, many options regarding the surgical treatment of the disease has been described, the consensus about treatment stills remains unsatisfactory, as all the surgical methods have encountered with different rate of recurrences. our aim in this study is to compare the widely used technique in pilonidal sinus surgical treatment modified limberg flap transposition and relatively less used technique lateral advancement flap transposition with burrow's triangle, in the terms of vas scores, recurrence, postoperative complications, surgical site infections in the first 6 months.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of pilonidal sinus disease * must be able to suitable for the surgery exclusion criteria: * patients with recurrent pilonidal sinus disease * patient whom is not suitable for surgery

Keywords: flap pilonidal sinus vas recurrence
second laparoscopic surgery for recurrent unilateral endometriomas.

Conditions: Endometrioma; Endometriosis; Surgery

Summary: this retrospective case-control study was performed in an academic centre for the diagnosis and treatment of endometriosis. it included patients with recurrent unilateral endometriomas who were previously operated for the same condition (cases) and patients without recurrency who previously underwent surgery for unilateral endometrioma (controls). the primary outcome of the study was to assess the impact on ovarian reserve of second surgery for recurrent unilateral endometriomas. the evaluation of ovarian reserve was performed by assessing serum anti-mullerian hormone (amh) level, serum follicle-stimulating hormone (fsh) level, 17-beta estradiol level and antral follicle count (afc).


Eligibility criteria:
inclusion criteria: * reproductive age (at the time of both surgical procedures); * two surgical procedures on the same ovary (stripping of endometrioma with * largest diameter ≥ 4 cm; cases) performed at our institution; * one surgical procedures (stripping of endometrioma with largest diameter ≥ 4 cm; controls) performed at our institution; * histological diagnosis of ovarian endometriomas; * complete assessment of ovarian reserve at routinary follow-up at our institution. exclusion criteria: * patients aged ≥ 40 years at the time of primary surgery; * surgical procedures on the contralateral ovary (at primary or second-line surgery); * previous salpingectomy or hysterectomy; * unilateral ovariectomy at the time of first or second surgery; * ultrasonographic diagnosis of persistent endometrioma after first surgery; * additional surgical procedures for endometriomas or for other ovarian diseases before first surgery and between first and second surgery; * hormonal treatment within 3 months from ovarian reserve assessment; * patients followed-up \< 3 months after second-line surgery (for cases). * pregnancy and/or breastfeeding during the study period.
therapy of obesity and diabetes mellitus type 2

Conditions: Obesity; Diabetes Type 2; Weight Loss

Summary: to evaluate a standardized weight-loss program as treatment option for obesity and type 2 diabetes, changes in body composition and metabolic control are investigated in obese patients with diabetes.

men and women with obesity and diabetes mellitus type 2 are invited to join a standardized weight-loss program (six weeks of formula diet, followed by the reintroduction of regular food with gradually increasing energy intake over nine weeks) for a duration of 15 weeks. all subjects undergo bioelectrical impedance analyses to investigate body composition and magnet resonance imaging to measure fat mass and fat fractions of abdominal organs, at three time points: first before the program, then at the end of the six weeks of formula diet and finally, at the end of the program after 15 weeks. laboratory data are measured before and after the program.

Eligibility criteria:
inclusion criteria: * known type 2 diabetes * body-mass-index between 27 and 45 kg/m² exclusion criteria: * treatment with incretin mimetic drugs \< 3 month * pregnancy * immobilization * severe heart, liver or renal failure * dementia * eating disorder * alcoholism

Keywords: formula diet
assessing the role of intravenous lipid emulsion as a life saving therapy in pesticides toxicity

Conditions: Pesticide Poisoning

Summary: intravenous lipid emulsion is an established, effective treatment for local anesthetic systemic toxicity. it is also efficacious in animal models of severe cardiotoxicity caused by a number of other medications. recent case reports of successful resuscitation suggest the efficacy of lipid emulsion infusion for treating non-local anesthetic overdoses across a wide spectrum of drugs. the present study will focus on the potential role of intravenous lipid emulsion as an adjuvant therapy in pesticides toxicity.


Eligibility criteria:
inclusion criteria: * patients with acute pesticide intoxications with poison severity score 2 or 3 admitted in icu of pcc-asuh exclusion criteria: * patients less than 18 years and more than 65 years. * pregnant and lactating females. * presence of medical diseases (e.g. renal, hepatic, cardiovascular, neurological diseases and chronic pancreatitis.) * allergy to soya-, egg-or peanut protein
effects of oral inositol supplementation on obstetrics outcomes in pcos women

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovarian syndrome (pcos) is a heterogeneous, multifaceted and complex disorder characterized by insulin resistance (ir), hyperinsulinemia, and hyperandrogenism leading ovarian disfunction and infertility. given the central pathogenic role of ir in the endocrine, reproductive, and metabolic disturbances of pcos, several pharmacological and non-pharmacological approaches have been proposed to counteract the hyper insulinemic ir typical of the syndrome. two inositol stereoisomers, myo-inositol (mi) and d-chiro-inositol (dci), captured the attention of researchers for their insulin-sensitizing actions, which configure them as proper candidates for the treatment of pcos. very few studies reported on spontaneous clinical pregnancy rates, none were powered for this outcome, and none reported on the clinically relevant outcome of live birth. therefore, data about clinical pregnancy rate, live birth rate, and miscarriage rate comparing inositols with placebo are limited. nevertheless, regarding infertility the primary outcomes that should be considered are clinical pregnancy rate, miscarriage rate and live birth rate. although many studies showed improved hormonal and metabolic profile and improved ovulation rate and higher quality and number of oocyte retrieved in assisted reproductive technology (art) in pcos women after inositols administration, data about clinical pregnancy rate, live birth rate, and miscarriage rate are limited with several concerns regarding interpretation of the studies. furthermore, independently by the effect on pcos related infertility, few data are available about the role of inositol on obstetrics outcomes of pregnancies conceived after treatment with inositol and/or orally supplemented during pregnancy. considering that the combination of mi and dci alleviate many of the metabolic dysregulations typical of pcos thanks to insulin-sensitizing actions, it is plausible consider a beneficial effects on pregnancy complications such as gestational diabetes and preeclampsia.


Eligibility criteria:
inclusion criteria: * pregnancy spontaneously conceived in women with pcos diagnosed by rotterdam criteria that starts oral supplementation before conception. exclusion criteria: * any kwon pre-pregnancy disease. * any other pharmacological, non-pharmacological or nutraceutical treatment (beside oral folic acid supplementation) more than 3 months before the enrollment (wash-out period) or during the trial, or until the development or pregnancy-induced/related diseases requiring pharmacological treatments.

Keywords: inositol polycystic ovarian syndrome pregnancy obstetrics outcomes gestational diabetes preeclampsia