Kornimate/medical-research-clean huggingface dataset:
registro malattia diverticolare (registry of diverticular disease)

Conditions: Diverticulum, Colon; Diverticulitis

Summary: to determine the clinical characteristics and risk factors for the onset of diverticular disease and its complications in the italian population.

diverticulosis and diverticular disease present a high prevalence rate in the world population, especially in the western world. diverticulosis of the colon is an extremely common condition in industrialized countries and its prevalence rate increases with age, and exceeds 60% in patients aged over eighty. although the course of diverticulosis is normally free of symptoms and complications, about 15% of patients develop symptoms often undistinguishable from those of the irritable bowel syndrome, such as abdominal pain, bowel disorders and bloating. about 5% of patients with diverticular disease develop an episode of uncomplicated acute diverticulitis with abdominal symptoms accompanied in some cases by systemic symptoms, such as fever or malaise and laboratory evidence of activation of the inflammatory process. in a minority of these cases, the patient suffers major complications such as the development of abscesses, fistulae, haemorrhage or stenosis (1). the pathogenesis of diverticulosis and diverticular disease remains unclear. genetic predisposition, risk factors (2), relationships with the irritable bowel syndrome (3-5), a low-fibre diet, involvement of intestinal microbiota and the mucosal immune activation (6-7) remain elements whose significance is yet to be confirmed. the management, medical and surgical approach and the prevention of relapses of diverticular disease remain above all empirical and supported by few controlled clinical studies (8-9). this scenario of uncertainty may result in waste and diagnostic/therapeutic pathways not always suitable for a disease with such a high prevalence rate. on the basis of these considerations, there is a need to collect systematic information useful for determining aetiopathogenetic aspects and outcomes with greater accuracy. objectives of the study the purpose of the study is to structure a national register on an it platform useful for determining: 1. the clinical aspects of diverticulosis/ diverticular disease 2. the risk factors of diverticulosis/ diverticular disease 3. the risk of complications of diverticular disease and the factors of risk and protection against complications. 4. the management of medical and surgical treatments

Eligibility criteria:
inclusion criteria: all consecutive patients satisfying the following inclusion criteria are recruited: 1. acceptance to sign the informed consent form 2. age \>18 3. instrumental evidence (endoscopic or radiological) of diverticula in the colon. exclusion criteria: 1. refusal to sign the informed consent form 2. inability to comply with the study procedures

Keywords: registry diverticular disease diverticulitis uncomplicated diverticular disease
delaying the superficial inferior epigastric artery (siea) flap and determining the change in siea diameter and blood flow

Conditions: Breast Neoplasms

Summary: the purpose of this study is to determine whether delaying the superficial inferior epigastric artery (siea) flap results in widening of diameter and enhancing of blood flow of its donor artery.


Eligibility criteria:
inclusion criteria: * patients undergoing surgery for lower extremities varicose veins exclusion criteria: * patients who previously underwent operations of the lower abdomen (abdominoplasty and inguinal hernia repair)

Keywords: superficial inferior epigastric artery flap, delay phenomenon
using videos in advance care planning for patients with advanced cancer

Conditions: Advanced Cancer

Summary: to compare the decision making of subjects with advanced cancer having a verbal advance care planning discussion compared to subjects using a video.

a.1. aim 1: to recruit 150 subjects with advanced cancer and randomly assign these subjects to one of two advance care planning (acp) modalities: 1. a video visually depicting cpr (intervention) or 2. a verbal narrative describing the cpr. hypothesis 1: it is feasible to recruit and randomize 150 subjects with advanced cancer. a.2. aim 2: to compare the care preferences for cpr among 150 subjects randomized to video vs. verbal narrative intervention. hypothesis 2: subjects randomized to the video intervention will be significantly more likely to opt not to have cpr compared to those randomized to the verbal narrative. a.3. aim 3: to compare knowledge assessment of cpr for 150 subjects randomized to video vs. verbal narrative intervention. hypothesis 3: when compared to subjects randomized to the verbal narrative arm, subjects in the video group will have higher knowledge assessment scores when asked questions regarding their understanding of cpr.

Eligibility criteria:
inclusion criteria: 1. diagnosis of cancer that falls under one of the following: a. all patients with brain cancer, inoperable hepatocellular/bile duct/gallbladder cancer, incurable non-small cell lung carcinoma (wet iiib or iv), extensive stage small cell lung cancer, inoperable mesothelioma, inoperable pancreatic cancer or; metastatic gastric or esophageal cancer, metastatic melanoma, or b. patients with the following cancers, if first-line therapy has failed and limited response is expected to second-line therapy: breast cancer, colorectal cancer, head and neck cancer, leukemia, ovarian cancer, prostate cancer, renal cancer, sarcoma, lung cancer, myeloma, or lymphoma, or c. less than one year prognosis. 2. ability to provide informed consent, 3. cognitive ability to participate in the study 4. ability to communicate in english. exclusion criteria: 1. inability to make decisions, 2. non-english speaking, 3. new patient visit

Keywords: advanced cancer
preoperative progression of macular holes

Conditions: Macular Holes

Summary: knowledge of the natural history and progression of macular holes is mainly limited to the studies from the pre-optical coherence tomography era. by observing macular holes preoperatively we are able to determine the extent of the preoperative macular hole progression. at our institution macular holes are treated in an elective setting. the majority of macular holes undergo a 2-step sequence of phacoemulsification and intraocular lens implantation followed by vitrectomy. we wish to observe the effect of time and cataract surgery on the progression of macular holes prior to vitrectomy.


Eligibility criteria:
inclusion criteria: * idiopathic macular hole stage ii-iv * informed consent * duration of symptoms ≤ 24 months exclusion criteria: * previous vitreomacular surgery * ocular trauma * significant visual function affecting disease (proliferative diabetic retinopathy, diabetic macular edema, exudative macular degeneration)

Keywords: macular holes progression
a study of indoximod in combination with (7+3) chemotherapy in patients with newly diagnosed acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: the purpose of this study is to characterize the regimen limiting toxicities (rlt) and recommended phase 2 dose (rp2d) of indoximod in patients with newly diagnosed aml receiving remission induction chemotherapy with cytarabine and idarubicin.


Eligibility criteria:
inclusion criteria: * a histologically or pathologically confirmed diagnosis of aml based on who classification with or without extramedullary disease except for central nervous system disease. * ecog performance status ≤ 2 * left ventricular ejection fraction (lvef) ≥ 50% * female patients of childbearing potential must have a negative pregnancy test \< 1 week prior to enrollment. * ability to understand and willingness to sign a written informed consent document. exclusion criteria: * patients receiving any other investigational agents or immunotherapy * patients who have received prior chemotherapy for aml with the exception of hydroxyurea or leukapheresis for leukocytosis; prior hypomethylating or immunomodulatory agents for mds are allowed * previous allo-hsct of any kind * active, uncontrolled infection including known hepatitis b or c * active autoimmune disease and chronic inflammatory conditions requiring concurrent use of any systemic immunosuppressants or steroids. * history of any other active cancer diagnosis * pregnant women * known hiv-infected patients

Keywords: aml
investigating the potential psychological impact of early screening and long-term monitoring for adolescent idiopathic scoliosis among patients and caregivers

Conditions: Adolescent Idiopathic Scoliosis; AIS; Scoliosis

Summary: adolescent idiopathic scoliosis (ais) is a three-dimensional deformity of the spine of unknown aetiology, characterised by a lateral curvature and vertebral rotation. its prevalence is estimated to be 2.5% in children between aged 10 and 16 in hong kong. despite concerns regarding the psycho-social issues patients face at and after ais screening, there is no study that directly address this subject. the investigator propose to conduct a prospective longitudinal study on the psycho-social impact of ais early screening and long-term monitoring amongst patients and their caregivers. the proposed study will bridge this research gap by evaluating a cohort of newly-diagnosed patients with ais through the school screening program and their caregivers. a mixed-methods research approach to tap into the distinct social, behavioural, emotional and parental experiential profiles will be used. patterns across different profiles can enhance the investigator's understanding of which aspects of ais early screening and long-term monitoring can adversely affect patients' psychological well-being. findings will facilitate targeted approaches to address specific psycho-social impact of scoliosis and its treatment, heighten compliance to long-term monitoring and prevention of scoliosis progression, and mobilise a new clinical care model that addresses patient and clinician concerns.


Eligibility criteria:
inclusion criteria: 1. diagnosis of structural scoliosis, and 2. developmentally normal cognitive function exclusion criteria: 1. a nonspinal cause of scoliosis, patients who do not intend to stay in this country for the duration of treatment, and 2. those who cannot fill in the questionnaires

Keywords: psychological impact
use of pancreatic enzymes in short bowel syndrome

Conditions: Short Bowel Syndrome

Summary: patients with short bowel syndrome have a high mortality rate that is mainly attributed to complications from central lines and long-term intravenous (iv) nutrition. there are few medical therapies to date that improve gut absorption in patients with short bowel syndrome. the primary objective of this study is to evaluate if absorption from the gi tract improves in subjects with short bowel syndrome following therapy with pancreatic enzymes.

this is an interventional study of subjects with short bowel syndrome to determine if enteral absorption improves following therapy with pancreatic enzymes. the study will assess enteral absorption and nutritional status at baseline through a series of stool tests, blood tests, and anthropometric measurements. following approximately ten days of therapy with pancreatic enzymes, the study will reassess enteral absorption.

Eligibility criteria:
inclusion criteria: * history of a small bowel resection with subsequent dependence on parenteral nutrition for at least three months * age 4 years to 65 years * usual state of health for the past two weeks with no medication changes * able to participate in a study for about four weeks with four study visits * able to take pancreatic enzyme medication orally exclusion criteria: * significant disease other than short bowel syndrome affecting the gastrointestinal tract that impacts absorption or digestions * motility disorder * medications that directly alter fat absorption * cholestatic liver disease defined as a serum conjugated bilirubin greater than 1.0 mg/dl, chronic renal failure, gout, or hyperuricemia * history of a pork allergy * women who are pregnant or lactating * history of fibrosing colonopathy those subjects who are eligible for the malabsorption blood test (mbt) test will be excluded if they have a history of a soy or safflower oil allergy.

Keywords: pancreatic enzymes
influences of different temporary cement on retention rate of temporary crowns

Conditions: MTA; Calcium Hydroxide; Dental Crown

Summary: the aim of this study is through a randomized clinical trial, double blind, split-mouth, evaluate the success rate (retention rate and dental sensibility) of temporary dental crown cemented on vital teeth. the composition of the cement (based on calcium hydroxide; and based on mineral trioxide aggregate) will be evaluated. data will be collected, tabulated and submitted to statistical analysis.

the confecction of temporary prosthesis is a fundamental step in the prosthetic process of definitive total crowns. the temporary cementation should provide sufficient retention between the intervals of the consultations, be biocompatible and not present high solubility. the aim of this study is through a randomized clinical trial, double blind, splithmouth, evaluate the success rate (retention rate and dental sensibility) of temporary dental crown cemented on vital teeth. the composition of the cement (based on calcium hydroxide; and based on mineral trioxide aggregate) will be evaluated. twenty participants with at least two vital teeth with the need to confection of definitive total crowns (each participant) will be selected who present. the teeth will be randomly divided into 2 different groups according to the temporary cement composition (based on calcium hydroxide; and based on mineral trioxide aggregate). data will be collected, tabulated and submitted to statistical analysis

Eligibility criteria:
inclusion criteria: * healthy volunteers; both genres; presence of at least two teeth with indication of total crowns; good oral hygiene. exclusion criteria: * dentures or orthodontics; presence of periodontal disease and,or parafunctional habits; systemic disease and, or severe psychological; constant use of analgesic and, or anti-inflammatory or allergic response to dental products.
sleep apnea and visual perceptual skill learning

Conditions: Apnea

Summary: the purpose of this study is to determine whether obstructive sleep apnea affects sleep dependent memory and learning. subjects with apnea will be given a test of perceptual skill learning (the visual discrimination task (vdt)) that has previously been shown to depend on sleep. subjects will be tested on this task before and after sleep. the difference in performance after sleep compared to before sleep provides a measure of sleep dependent learning. participants will be tested on one night when they have less apnea because they are using continuous positive airway pressure (cpap) as prescribed by their physician, which is well known to reduce apnea; and on another night when they are in their native state and have a greater degree of apnea. memory performance will be compared between the two nights to determine how apnea affects sleep dependent memory.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of sleep apnea * use pap therapy as prescribed by his/her physician for 3-4 weeks prior to enrollment * right-handed exclusion criteria: * major neurological or psychiatric condition * chronic pain condition * learning disabilities * serious brain or head injury (e.g. seizure, stroke, head trauma) * major surgery or general anesthesia in the past year * pregnant or nursing * problems with eyes or vision (besides corrected-to-normal with glasses or contacts) * past diagnosis of infection that can affect the brain (e.g. meningitis, hiv/aids) * medications that affect sleep (antidepressants, muscle relaxants, sleep aids, beta-blockers, stimulants, or corticosteroids) * recreational drug use, including marijuana * night-shift work * cancer or cancer treatment in the last 2 years * smoke more than 10 cigarettes per day * consume more than 3 caffeinated foods or beverages per day

Keywords: memory
aerobic capacity and strength exercise in takayasu's arteritis

Conditions: Physical Activity; Takayasu Arteritis

Summary: takayasu's arteritis is a primary systemic vasculitis that affects large vessels and their main branches. the objectives of the present study were to assess: a) the aerobic capacity (ca); b) security of the acute strength exercise session; c) correlation between ca, as well as strength exercise session, with demographic, clinical, therapeutic, comorbid parameters, and presence and degree of vascular damage; d) serum levels of the cytokines

takayasu's arteritis (ta) is a primary systemic vasculitis that affects large vessels and their main branches. it mainly affects young women. blood vessel inflammation may result in stenosis, occlusions, ectasias and/or aneurysms and, consequently, difference of blood pressure between limbs and vascular claudication. aerobic capacity (ca) is the measure of oxygen uptake, transport and use by the body, characterizing the individual's ability to perform activity. it is also a tool that can predict cardiovascular diseases. our group has been a pioneer in demonstrating that ca is decreased in the small sample of the young women with ta. in addition, the safety and efficacy of aerobic exercises in this sample of patients were shown, as well as the influence of these sessions on the pro-inflammatory and angiogenic serum levels of the cytokines. however, due to the small samples, it was not possible to correlate ca with clinical and laboratory parameters and also with the presence of vascular damage. moreover, to date, no studies have evaluated securityof an acute strength exercise session in ta.therefore, thes objectives of the present study were to evaluate: a) the ca; b) security of the acute strength exercise session; c) correlation between ca, as well as strength exercise session, with demographic, clinical, therapeutic, comorbid parameters, and presence and degree of vascular damage; d) serum levels of the cytokine.

Eligibility criteria:
inclusion criteria: * classification criteria of takayasu's arteritis * sedentarism exclusion criteria: * peripherical arterial diseases * non-controlled cardiovascular diseases * neurological diseases * patients with walking problem

Keywords: takayasus's arteritis physical exercises rheumatic diseases systemic vasculitis
an intervention to reduce sedentary behavior for black adults with chronic kidney disease

Conditions: Chronic Kidney Disease(CKD)

Summary: reset-ckd is evaluating an intervention to support black adults with chronic kidney disease (ckd) to reduce their sedentary (e.g., sitting) time. half of the participants will be randomized to the intervention, where the goal is to support individuals to reduce their sitting time, and the other half will be randomized to an attention control condition that provides ckd-related education not related to sedentary behavior. all participants will be followed for 12 weeks.


Eligibility criteria:
inclusion criteria: * self-identifies as black or african american * age ≥35 to ≤80 years old * ckd stage 1-4 * self-reported 6 or more hours/day of sedentary time * ability to speak/read/understand english * has access to a telephone exclusion criteria: * being unable to walk 1 block * being unable to stand from a seated position without assistance * using a wheelchair, walker, or cane for all of their ambulation * presence of a condition(s) or diagnosis, either physical or psychological, that precludes participation, including: lower-extremity amputation (aka or bka) without prosthetic, orthopedic condition that would preclude prompted sit-to-stand transitions or standing, neurologic or psychiatric condition that would preclude prompted sit-to- stand transitions or standing, severe cognitive impairment, unstable coronary artery disease (i.e., angina with activity), orthostatic hypotension * kidney transplant * any other condition that the investigator considers precludes participation in the trial * participated in the patient advisory board

Keywords: sedentary
0.01% hypochlorous acid in the treatment of blepharitis

Conditions: Blepharitis

Summary: this is a multi-center, multidisciplinary, open-label, randomized controlled prospective clinical study.


Eligibility criteria:
inclusion criteria: 1. age 18 or older. 2. anterior or mixed (anterior + posterior) blepharitis. 3. similar clinical condition of both eyes. 4. a negative urine pregnancy test result for women of childbearing potential 5. normal lid position and closure 6. ability to understand and provide informed consent to participate in this study 7. willingness to follow study instructions and likely to complete all required visits. exclusion criteria: 1. any ocular surface disease other than blepharitis. 2. known allergy to hypochlorous acid or boric acid. 3. eye surgery in the last 6 months. 4. history of stevens-johnson syndrome or ocular pemphigoid 5. ocular trauma in the last 6 months. 6. use of contact lenses in the last 6 months. 7. pregnancy or lactation. 8. daily use of makeup on lashes. 9. any ocular or systemic medication that might affect the ocular microbiota (antibiotics, immunosuppressants, steroids). 10. pregnant or lactating women 11. signs of current infection, including fever and current treatment with antibiotics 12. liver, renal, or hematologic disease 13. the use of any other investigational drug

Keywords: blepharitis hypochlorous acid eyelid cleanser eyelid hygiene meibomian gland dysfunction
an investigation to evaluate sound coding enhancements in adult cochlear implant recipients

Conditions: Cochlear Implant Recipients; Hearing Loss, Cochlear

Summary: this study will evaluate a range of experimental sound coding strategies that may improve hearing for cochlear implant recipients.


Eligibility criteria:
inclusion criteria: * users of an approved nucleus cochlear implant. * aged 18 years or older (no upper age limit). * open set speech understanding sufficient to complete the study protocol as judged by the investigator. * fluent speaker in the language used to assess speech perception performance, as determined by the investigator. * willing and able to provide written informed consent. exclusion criteria: * unable or unwilling to comply with the requirements of the clinical investigation as determined by the investigator. * additional health factors, known to the investigator, that would prevent or restrict participation in the audiological evaluations. * investigator site personnel directly affiliated with this study and/or their immediate families; immediate family is defined as a spouse, parent, child, or sibling. * cochlear employees or employees of contract research organisations or contractors engaged by cochlear for the purposes of this investigation * current participation, or participation in another interventional clinical study/trial in the past 30 days, involving an investigational drug or device (unless the other investigation was/is a cochlear sponsored investigation and determined by the investigator or sponsor to not impact this investigation).