Kornimate/medical-research-clean huggingface dataset:
physiotherapy vs telerehabilitation after volar plating of distal radius fracture

Conditions: Orthopedic Procedures; Physical Therapy Modalities; Postoperative Care; Rehabilitation; Wrist Fractures

Summary: trial purpose is to research the outcome comparing traditional physiotherapy vs telerehabilitation after volar plating of distal radius fracture. patients with distal radius fracture that meet the operative criteria set by the finnish current care guidelines are randomized (1:1 computer generated sequence with random block size) to two parallel groups and will undergo operative treatment and traditional physiotherapy vs telerehabilitation. baseline data is collected preoperatively and patients are followed at 1, 3 and 12 months after enrollment. the primary end-point is 3 months and the primary outcome is the patient-rated wrist evaluation (prwe).


Eligibility criteria:
inclusion criteria: * distal radius fracture, which applies the surgical requirements * age between 18 to 65 years * non concomitant injuries including ligament injuries and distal ulna fractures, however ulnar styloid avulsion is accepted * no significant comorbidities * no previous problems with the examined hand * ability to understand finnish fluently exclusion criteria: * high energy or multiple injuries * open fractures * injury of both upper extremities * other operative injury on the same side * rheumatoid arthritis of other inflammatory joint disease * heavy smoker (over 20 cigarettes per day) * disease of medication slowing ossification * alcohol or drug abuse * psychiatric disorder with poor treatment balance * neurological disorder which affects the function of the injured extremity * fixation material other than a volar locking plate * fracture fixation is not stable enough to start rehabilitation after 14 days
fluid administered according to pvi versus fluid management in laparoscopic trendelenburg surgeries

Conditions: Fluid Overload Without Edema

Summary: investigating the ideal fluid management in trendelenburg positions during lower abdominal laparoscopic surgeries in gynecological oncology and surgical oncology patients

laparoscopic lower abdominal surgeries include carbon dioxide (co2) insufflation and an advanced trendelenburg position with the head down. increased intra-abdominal pressure can reduce cardiac index and cause changes in total body fluid balance. however, the head down trendelenburg position increases intracranial pressure and preload. according to traditional fluid management, intraoperative fluid deficit is calculated according to the 4-2-1 rule, by summing up hourly basal fasting level, intraoperative losses due to degree of tissue trauma (1-2mlt/kg/h in minor surgeries, 2-4mlt/kg/h in medium surgeries, 4-8mlt/kg/h in major surgeries), blood losses, urine and losses from nasogastric tube. preservation of intravascular volume and thus provision of hemodynamic stability are among the factors affecting postoperative morbidity and mortality. some studies have shown that standard fluid therapy is more than necessary. current guidelines recommend more restrictive approaches by ensuring hemodynamic stability. masimo, which we also use routinely in our clinic, is a device designed for continuous noninvasive monitoring of arterial hemoglobin functional oxygen saturation (spo2), pulse rate (pr), pleth variability index (pvi) and pleth respiratory rate (rrp) pi (perfusion index) values. in our study, in the individualization of the recommended target-oriented restrictive fluid therapy in major surgeries, by comparing the calculated fluid amount with traditional fluid management with pvi values (pvi is evaluated between 0-100. normavolemia 15-25 low fluid responsiveness \ 25) and when the patient's massimo pvi score is \>25, 300cc bolus fluid will be administered and fluid will be loaded at an average speed and the pvi value will be reduced below 25. when the patient's massimo pvi value is below 25, restrictive fluid therapy will be followed.(a crystalloid fluid infusion of 2 ml/kg was administered to the patients.) the aim was to investigate the ideal fluid management in trendelenburg positions in lower abdominal laparoscopic surgeries performed in gynecological oncology and surgical oncology patients.

Eligibility criteria:
i̇nclusion criteria: * between the ages of 18-80 * patients with asa score ii iii * laparoscopic lower abdominal surgery (patients undergoing gynecological oncology and surgical oncology surgery) exclusion criteria: * asa score iv * patients with heart failure and chronic kidney disease * patients who did not agree to participate in the study * cases that started laparoscopically and converted to laparotomy
transdermal ketoprofen to treat mild to moderate osteoarthritis (oa) pain of the knee

Conditions: Pain; Osteoarthritis, Knee

Summary: the purpose of the study is to evaluate the safety and effectiveness of the investigational ketoprofen patch with a controlled heating patch, compared to placebo (inactive substance) for the treatment of pain caused by osteoarthritis.

proof-of-concept study, multicenter, randomized, double-blind, parallel-group, placebo-controlled study designed to evaluate the safety and efficacy of a transdermal ketoprofen patch with chadd heat versus a placebo patch with dummy heat in patients with mild to moderate pain associated with osteoarthritis of the knee. after screening, patients discontinue all analgesic medication (except ≤325 mg aspirin daily for cardioprotective purposes). patients selected a target knee (right or left), and all efficacy evaluations were completed with respect to this target knee. after discontinuing analgesics for at least 48 hours, and when the average pain intensity over the previous 24 hours for the target knee was ≥40 mm using a 100 mm visual analog scale (vas), patients were randomized in a 1:1 fashion to receive treatment with either the transdermal ketoprofen patch with chadd heat or the placebo patch with dummy heat. patients treated the target knee each night for 12 hours (± 1 hour) for 4 weeks. patients returned to the study site every 7 days (± 1 day) for study evaluations. throughout the study, patients were allowed to take up to 2000 mg acetaminophen per day as rescue medication; however, rescue medication was not allowed within the 48 hours prior to efficacy evaluations.

Eligibility criteria:
inclusion criteria: * patient is between forty (40) and seventy-five (75) years of age. * patient has clinically diagnosed radiographic evidence of osteoarthritis of the knee within the past year. exclusion criteria: * patient has known allergy to nonsteroidal anti-inflammatory drugs (nsaids) (including aspirin) or has a suspected hypersensitivity, allergy or other contraindication to any compound present in the study medication. * patient has a history of significant gastrointestinal disease or previous gastrointestinal upset following nsaid administration.

Keywords: pain osteoarthritis oa mild to moderate osteoarthritis (oa) pain of the knee
sarcopenia and aging

Conditions: Sarcopenia

Summary: objective: evaluate the muscular strength in the ageing process and identify the changes between the abdominal muscles, upper and louver edges. method: 48 individuals participated in this study, being divided into four groups according to the age: (g1) 11to 18 years old, (g2) 20 to 26 years old, (g3) 45 to 60 years old and (g4) 66 - 82 years old. the excluding criterion included people who work out more than three times a week, severe arthrosin, stroke, significant cognitive deficit , obesity, use of ortheses for louver members or any break, with or without metallic implant. the evaluation instruments used were: (1) esfigmomanômetro (em), (2) trunk flexor in the supine position,, (3) jamar dinamômetro and (4) preston pinch gauge dinamômetro.

forty-eight subjects participated voluntarily in this work and is divided into four groups of 12 participants with 6 men and 6 women: (g1) 11 to 18 years (g2) 20 to 26 years (g3) from 45 to 60 and (g4) 66 to 82 years, selected in dependency of unifran and residences of the city of franca, sao paulo - brazil. to evaluate muscle strength, a bd sphygmomanometer was used to analyze the strength of flexors and extensors of the knee. the jamar dynamometer was used to assess the functional integrity of the upper and preston pinch gauge dynamometer for evaluation of gripper hands.

Eligibility criteria:
inclusion criteria: * absence of the basic pathology that interferes directly in the muscle exclusion criteria: * people who work out more than three times a week * severe arthrosin * stroke * significant cognitive deficit * obesity * use of ortheses for louver members or any break * with or without metallic implant

Keywords: ageing sarcopenia muscular contraction
tailored versus empiric therapy for helicobacter pylori treatment

Conditions: Helicobacter Pylori Infection

Summary: with markedly increased antibiotic resistance and unsatisfactory efficacies of common empiric eradication regimens in the mainland of china, tailored therapy may be the best choice to achieve good efficacy. this study compared the eradication rates, safety, and compliance of antibiotic sensitivity-based tailored therapy compared with empiric bismuth quadruple therapy in the naive patients with helicobacter pylori infection.


Eligibility criteria:
inclusion criteria: * participants with non-ulcer functional dyspepsia or scarred peptic ulcer disease * ability and willingness to participate in the study and to sign and give informed consent * confirmed h. pylori infection exclusion criteria: * previous h. pylori eradication therapy * less than 18 years old * with history of h. pylori infection treatment * with previous gastric surgery * major systemic diseases * pregnancy or lactation * allergy to any of the study drugs * administration of antibiotics, bismuth, antisecretory drugs in 8 weeks prior to inclusion

Keywords: helicobacter pylori bismuth quadruple therapy tailored therapy empiric therapy clarithromycin susceptibility
evaluation of the efficacy of repetitive transcranial magnetic stimulation (rtms) low-frequency on craving in smoking dependence

Conditions: Smoking Cessation; Addiction

Summary: the fight against smoking is a public health priority. without help, fewer than 5% of des smokers are abstinent at 12 months after smoking cessation. despite well-managed attempts at smoking cessation with nicotine substitutes, the rate of success at 12 months in patients dependent on nicotine is only 18%. moreover, other therapeutic strategies (acupuncture, hypnosis...) have not proved to be effective. the investigators propose a new therapeutic strategy for smoking cessation, which is based on associating nicotine substitutes (to reduce physical symptoms of weaning from nicotine) with rtms at 1 hz to the right dorsolateral prefrontal cortex (dlpfc) for 2 weeks (to diminish craving for tobacco). the principal objective is to improve the success rate for smoking cessation attempts in patients who are highly dependent on nicotine, and who have failed using usual smoking cessation strategies.


Eligibility criteria:
inclusion criteria: * adult 18-65 years old * wishing to stop smoking * highly dependent on nicotine (score ≥ 7 on the fagerström self-questionnaire) * history of at least 2 failed attempts to stop smoking despite recommended treatments (nicotine, vareniciline, bupropion) exclusion criteria: * abstinence in the 3 previous months * absence of effective contraception for women * progressive chronic disease * ongoing psychiatric disorders * current addiction to other substances or cessation of less than one year * current treatment with psychotropic agents * epilepsy and other contra-indications for rtms (pacemaker, metallic clips or other electronic implants, head trauma, intracranial hypertension). * contra-indications for transdermal nicotine substitutes (recent myocardial infarction, unstable or worsening angina, prinzmetal angina, severe heart rhythm disorders, recent stroke, skin disorders that could interfere with the use of transdermal treatments, hypersensitivity to one of the constituents). * personnel working in the psychiatric and addictology unit of the chu (conflict of interest)
self-controlled study between 4-hour and 24-hour delayed radiographs in hsg using oscm

Conditions: Infertility

Summary: background of the study: hysterosalpingography (hsg) is widely used for the female infertility workup. many studies have demonstrated that the use of oil-soluble contrast medium (oscm) ethiodized oil for hsg surgery can improve pregnancy rates. however,the 24-hour delayed radiographs of oscm hsg also brought some inconvenience to the patients , for example, patients need to make two trips to the hospital. objective of the study: the purpose of this study was to compare oscm hsgs using 4-hour and 24-hour delayed radiographs in terms of diagnosing tubal patency and identifying the presence of pelvic adhesions. study design: prospective, open label, self - controlled study study population: infertile patients scheduled for an oscm hsg


Eligibility criteria:
inclusion criteria: * having spontaneous ovulation or inducing ovulation; * infertility lasting for 12 months; * conforms to the indications of hysterosalpingography; * understand and sign the informed consent; exclusion criteria: * iodine allergy or hyperthyroidism * acute genital tract inflammation or abnormal leucorrhea examination; * abnormal vaginal bleeding; * fever or preoperative temperature higher than 37.5℃ within 3 days before angiography; * severe insufficiency of cardiopulmonary or liver function; * during pregnancy and menstruation; * with complications that may cause subjects to be unable to follow the study plan or even endanger the patient's safety or social environment; * patients who are participating in other clinical studies or who are not suitable for inclusion in this study due to other reasons considered by the researchers.

Keywords: infertility hysterosalpingography oil-soluble contrast medium
non-invasive clinical imaging of cerebral metabolism following brain injury using 13c magnetic resonance spectroscopy.

Conditions: Traumatic Brain Injury

Summary: despite the decline in fatal traumatic brain injury (tbi) incidence in recent years, tbi morbidity remains a public health challenge and is the leading cause of disability in the united states. detailed knowledge of the metabolic alterations following tbi will provide a significant advancement to our understanding of the hypometabolic response to tbi, which is key information for the future development and testing of novel therapeutic interventions that by-pass or compensate for the metabolic dysfunction. the goal of this study is to determine the clinical utility of in vivo 13c mrs to identify specific metabolic alterations following tbi. we hypothesize that following tbi, metabolic pathways are altered causing an incomplete oxidative of glucose in neurons and astrocytes resulting in a decrease in cerebral metabolism.

despite the decline in fatal traumatic brain injury (tbi) incidence in recent years, tbi morbidity remains a public health challenge and is the leading cause of disability in the united states to combat these effects, new research is needed to identify mechanisms of injury that will lead to potential targets for therapeutic interventions that improve neurological outcome. one promising area of research is the cerebral metabolic dysfunction following tbi. studies of post-traumatic cerebral metabolism have shown that cerebral metabolic rate of glucose (cmrglc) decreases for a period of days, weeks or months after injury with the duration and degree of hypometabolism correlating to level of consciousness and a strong predictor of long-term neurological outcome. however, specific changes in intermediary carbohydrate metabolic pathways have not yet been identified. in addition, the role of astrocyte metabolism in the post-injury metabolism has not been studied. this study uses in vivo 13c magnetic resonance spectroscopy (mrs) at 3 tesla, a novel method in the clinical study of tbi, to non-invasively study the metabolic fate and flux of glucose (metabolized in both neurons and astrocytes) and acetate (metabolized in astrocytes) through metabolic pathways during the hypometabolic period.

Eligibility criteria:
inclusion criteria: 1. subjects will be at least 18 years of age without gender or ethnic restrictions. 2. severe accidental tbi defined as the lowest post-resuscitation gcs \< 8 prior to administration of sedatives or paralytics. 3. eligibility for mri per routine screening checklist. exclusion criteria: 1. history of neurosurgical intervention, excluding the placement of ventriculostomy shunt 2. history of a prior known brain injury with associated loss of consciousness. 3. history of a known neurological disorder prior to qualifying injury. 4. history of psychiatric disorder. 5. history of diabetes or current unstable serum glucose level. 6. renal insufficiency or known history of kidney disease. 7. known contraindication to mri such as, pacemaker, pregnancy, and/or other non-mr compatible implanted device.
evaluation of the efficacy of somatosensory rehabilitation of pain by vibrotactile stimulation on static mechanical allodynia

Conditions: Allodynia

Summary: this study aims to demonstrate that somatosensory rehabilitation of pain associated with static mechanical allodynia has superior efficacy over placebo treatment as well as over spontaneous changes.

this is a monocenter study. 45 patients will be enrolled in the study, allocated by randomization in 3 arms of 15 patients each. during the 38 week duration of the study, enrolled patients will be assessed at: * initial evaluation (first week of the study), * intermediary evaluation for every week and every modification of intensity of pain, * final evaluation at 10 weeks, * follow-up evaluation at 6 months.

Eligibility criteria:
eligibility criteria 1. male or female patients aged ≥18 years; 2. static mechanical allodynia for less than 3 months, whatever its etiology and topography; 3. probable peripheral or central neuropathic pain or defined according to the iasp criteria; 4. neuropathic pain diagnostic questionnaire dn4 score ≥ 4/10; 5. chronic pain with average intensity ≥ 4/10; 6. analgesic treatment unchanged within 15 days prior to screening, and not planned to be modified during the study; 7. patient who can attend follow-up visits during the study; 8. patient affiliated to a health insurance plan or entitled; 9. patient must be able to give informed consent in accordance with ich gcp guidelines and local legislation and/or regulations. exclusion criteria: 1. patient with neuralgia (spontaneous pain) with or without allodynia; 2. patient not able to participate actively to the rehabilitation exercises for physical reason, cognitive reason (ability to understand instructions) or behavioural reason (e.g. addiction...); 3. patient with complex regional pain syndrome (type i); 4. patients for whom cares cannot avoid any touch with allodynia area; 5. patient previously treated by a transcutaneous electrical nerve stimulation (tens); 6. prior treatment by somatosensory rehabilitation; 7. duration of stay in the medical center \< 11 weeks; 8. patient with cognitive disorder; 9. allodynia area of the patient presenting with conditions not recommended for vibrotactile stimulation: wound, unhealed nerve suture, recent skin transplantation, fragile organ such as eye.

Keywords: static mechanical allodynia somatosensory rehabilitation vibrotactile stimulation
prognostic value of each codon-specific kras mutation in colorectal cancer

Conditions: Colorectal Cancer

Summary: this retrospective study reviewed 3,144 patients who underwent surgery for colorectal cancer. this study was designed to comprehend the clinicopathological characteristics associated with individual codon-specific kras mutations in colorectal cancer.

this study was designed to comprehend the clinicopathological characteristics associated with individual codon-specific kras mutations in colorectal cancer including codon 12, 13, and 61. furthermore, the main objective of this study was to determine whether kras codon 13 mutation could serve as a prognostic biomarker of colorectal cancer in a relatively large cohort of subjects. overall survival (os) and recurrence-free survival (rfs) were calculated from the date of surgery and compared using the kaplan-meier method and log-rank test. for analysis of risk factors for tumor recurrence, cox proportional hazards regression model was used with the covariance input criterion set as \< 0.1. patients were subdivided based on primary tumor location (colon versus rectum), and msi status (mss/msi-low versus msi-high).

Eligibility criteria:
inclusion criteria: * patients underwent surgery for colorectal cancer from january 2009 to december 2019. exclusion criteria: * incomplete data on kras mutation * incomplete data on microsatellite instability (msi) status * dual or triple kras mutation * stage iv
artificial intelligence model for growth prediction of ovarian cancer organoids

Conditions: Ovarian Cancer

Summary: the present study aims to collect early bright field image of patient-derived organoids with ovarian cancer. by leveraging artificial intelligence, this study will seek to construct and refine algorithms that able to predict growth of ovarian cancer organoids.


Eligibility criteria:
inclusion criteria: * patients must have histologically confirmed diagnosis of epithelial ovarian cancer * patients received biopsy or puncture to obtain tumor tissues or malignant effusion * patients voluntarily participated in the study and signed informed consent. exclusion criteria: * non-epithelial ovarian cancer * no sufficient amount of tumor tissues or malignant effusion for organoids establishment.