Kornimate/medical-research-clean huggingface dataset:
association between cardiovascular diseases and mental illness

Conditions: Cardiovascular Diseases; Mental Disorder

Summary: cardiovascular diseases (cvd) are important public health concerns around the world and closely associated with the development and progression of mental illness, which in turn increases the risk of developing cardiovascular diseases. this study aimed (1) to explore the known or unknown protective and risk factors underlying this comorbidity using questionnaires; (2) to study the biomarkers (body fluid, imaging) of the participants, and to find the influence on the relationship between cvd and mental health; (3) to identify high-risk populations for mental disorders in cvd patients and to establish prediction models. (4) to establish a specialized medical database.

patients with depression and cardiovascular comorbidities have a worse prognosis, a sharply reduced quality of life, and a much higher incidence of fatal cvd events, such as acute infarction, than patients with a single disease. however, due to the variety of potential causative factors and clinical manifestations, population variability, long duration of the disease, as well as neurological disorders of the exact causative mechanism still unclear, the psychological assessment among patients with cardiovascular diseases is remarkably inadequate studied. in this study, two cohorts are established that include 2000 hospitalized patients and 5000 of the entire population. all individuals are screened for depression and anxiety. those who score positive will be advised to enroll in this study. patients are then randomized to receive collaborative care involving the patient, the patient's primary care physician, cardiologist and nurse case manager, or usual care is defined for each patient. whole blood and serum samples are obtained from all patients, which will be measured for a panel of metabolic and inflammatory indicators. patients in both cohorts will be monitored for depression severity and duration at 6 and 12 months after enrollment. a statistical technique is applied to determine the effect size of potential risk factors.

Eligibility criteria:
inclusion criteria: 1. outpatient and inpatient cardiology patients, diagnosed with at least one cardiovascular disease and at least one psychological disorder 2. cardiovascular diseases: acs (stemi, non-stemi, unstable angina), arrhythmia (atrial fibrillation, atrioventricular block), heart failure (stable/unstable), hypertension, cardiomyopathy (hypertrophic, dilated) 3. psychological disorders: structured interview diagnosed as depression, anxiety, insomnia; phq-9/gad-7 score ≥ 10 points. 4．18-70 years old exclusion criteria: 1. clear suicidal ideation: phq-9 item 9 suicide ideation ≥ 3 points 2. severe mental illnesses such as bipolar disorder, schizophrenia 3. currently under psychotherapy 4. severe cardiovascular diseases or other severe chronic life-threatening diseases 5. refusal to participate 6. abuse of alcoholism and drugs 7. pregnant or breastfeeding 8. cognitive impairment
positive emotional processing: exploring novel treatment targets in social phobia

Conditions: Social Anxiety Disorder

Summary: the purpose of this study is to test the effects of a computerized approach/avoidance training (aat) procedure in a sample of individuals diagnosed with social anxiety disorder (sad). the training procedure is designed to modify automatic approach responses for positive social stimuli. previous research has shown that a single administration of approach-positive aat influences social behavior in the laboratory. the goal of this study is to examine the effects of a four-session aat procedure on measures of positive social-emotional functioning. the investigators hypothesize that individuals assigned to the approach-positive aat condition will demonstrate larger increases in positive affect and improvements in social relationship functioning from pre- to post-assessment compared to those assigned to the control condition.


Eligibility criteria:
inclusion criteria: * age 18-55 * principal psychiatric diagnosis of generalized social anxiety disorder * liebowitz social anxiety scale (lsas) score ≥ 60 * ability to read and speak english sufficiently to complete study procedures exclusion criteria: * history of psychosis, mania, or substance dependence * current severe medical disorder that requires inpatient treatment or frequent medical follow ups including but not limited to: unstable hypertension, unstable angina, unstable diabetes mellitus, unstable cardiac arrhythmias, transient ischemic attacks, severe coronary artery disease, severe peripheral vascular disease, severe hepato-gastro-intestinal disease, severe infectious disease (e.g. hiv), recurrent severe headache or migraine, fainting spells, seizures, and history of traumatic brain injury with loss of consciousness \>30 minutes * current use of the following medications: antidepressants, benzodiazepines, antipsychotics, mood stabilizers, or other drugs that can acutely affect the hemodynamic response (methylphenidate and acetazolamide) * caffeine intake \>10 cups/day or recent significant changes in consumption * mri exclusions, including claustrophobia, cardiac pacemaker, metal fragments in eyes/skin/body (shrapnel), aortic/aneurysm clips, prosthesis, by-pass surgery/coronary artery clips, hearing aid, heart valve replacement, shunt (ventricular or spinal), electrodes, metal plates/pins/screws/wires, or neuro/bio-stimulators (tens unit), persons who have ever been a metal worker/welder, history of eye surgery/eyes washed out because of metal, women who are or may be pregnant (determined by a positive pregnancy test), women using an intrauterine device, vision problems uncorrectable with lenses, claustrophobia, inability to lie still on one's back for 60 minutes; prior neurosurgery; older tattoos with metal dyes; unwillingness to remove nose, ear, tongue, or face rings.
acetaminophen transfer across the placenta and the assessment of fetal well-being

Conditions: Fetal Testing; Transplacental Transfer of Acetaminophen

Summary: this study has two aims: 1. to evaluate placental transfer of acetaminophen from mother to baby transplacentally given from 30 minutes to 24 hours prior to cesarean delivery (34 patients) 2. to understand the impact of maternal acetaminophen use on fetal movement and breathing (20 patients)


Eligibility criteria:
inclusion criteria * pregnant females * age 18-44 * any race * any parity * singleton gestations * weight between 60-90 kg exclusion criteria * acetaminophen allergy * contraindication to acetaminophen use * chorioamnionitis * preeclampsia * diabetes mellitus * placental abruption * placenta previa * fetal anomaly * intrauterine growth restriction (iugr) * multiple gestations * maternal medical disease * acetaminophen use in the last 3 days * plan to donate or bank fetal cord blood

Keywords: fetal movement fetal breathing acetaminophen
extension study investigating the long-term safety and tolerability of repeat doses of fe200486 in prostate cancer patients

Conditions: Prostate Cancer

Summary: participants responding well in study fe200486 cs06 (nct00117949) were given the opportunity to continue treatment with degarelix under a clinical study until fe200486 was available on the market or until the study was discontinued. study fe200486 cs06a was to provide knowledge of the long-term safety and tolerability of fe200486.

the data include participants from both the main study (fe200486 cs06; nct00117949) and the extension study fe200486 cs06a.

Eligibility criteria:
inclusion criteria: each patient must meet the following inclusion criteria before entry into the study: * has given written consent before any study related activity is performed. a study related activity is defined as any procedure that would not have been performed during the normal management of the patient. * has had sufficient testosterone suppression (as defined in the withdrawal criteria of fe200486 cs06) for at least 28 days. exclusion criteria: any patient meeting any of the following exclusion criteria will not be entered into the study: * has been withdrawn from study fe200486 cs06 due to an adverse event, failure to achieve at least 28 days of testosterone suppression, insufficient prostate-specific antigen (psa) suppression as defined in study fe200486 cs06 in the absence of concomitant rise in testosterone level or non-compliance with protocol required procedures. * requires hormonal therapy for neoadjuvant purposes. * requires treatment with any other drug modifying the testosterone level or function. * is considered to be a candidate for curative therapy, i.e., radical prostatectomy or radiotherapy, within 6 months after visit 1. * has a history of severe asthma requiring daily treatment with inhalation steroids, angioedema or anaphylactic reactions. * has hypersensitivity towards any component of the investigational product. * has had a cancer disease within the last 10 years except for prostate cancer, and surgically removed basocellular or squamous cell carcinoma of the skin. * has a clinically significant neurologic, gastrointestinal, renal, hepatic, cardiovascular, psychological, pulmonary, metabolic, endocrine, hematological, dermatological or infectious disorder or any other condition, including excessive alcohol or drug abuse, which may interfere with trial participation or which may affect the conclusion of the study, as judged by the investigator. * any clinically significant laboratory abnormalities which, in the judgment of the investigator, would interfere with the patient's participation in this study or evaluation of study results (liver transaminases and bilirubin must be within normal limits). * has a mental incapacity or language barrier precluding adequate understanding or co-operation.

Keywords: prostate cancer androgen ablation therapy
comparison of manual skills, visual-motor integration and participation of children with and without type 1 diabetes

Conditions: Type 1 Diabetes; Hand Skills; Visual Motor Integration; Participation

Summary: the aim of this study is to compare visual-motor integration, academic achievement and participation in activities of daily living with and without type 1 diabetes.

there are two different groups in this study. the first group includes children with type 1 diabetes and the second group includes healthy children. children aged 8-12 years were included in the evaluation. beery-buktenica developmental test of visual motor integration , academic achievement (turkish, mathematics, social sciences exam scores) participation and environment measure-children an youth, jebsen taylor hand function test were used for evaluation.

Eligibility criteria:
inclusion criteria: 1. being between the ages of 8 and 12, 2. to be diagnosed with type 1 diabetes, 3. to be receiving education at primary education level, 4. children who agree to participate in the cooperative during the evaluations, 5. parents and children accepted to participate in the study. exclusion criteria: 1. any acute or chronic illness that affects the level of physical activity, 2. other types of diabetes, 3. mental problems, 4. having received psychiatric treatment, 5. having vision problems.
effect of prophylactic antibiotics on intra-operative culture results

Conditions: Infection; Arthroplasty

Summary: subjects will be consented and then determined randomly whether they will receive antibiotics prior to their surgery or during their surgery. each patient will have cultures taken before and during their surgery from the infected hip or knee. results will be compared after completion of the study.

it is unknown whether giving pre-operative antibiotics affects the results of intraoperative bacterial cultures. this is an important question as antibiotics are often not given prior to surgery out of concern that accurate culture results will not be obtained. it is important to obtain accurate cultures so that targeted antibiotic therapy can be used. however, delaying the administration of antibiotics also delays the onset of treatment. currently, the optimal course of action is unknown. the purpose of this study is to resolve this issue and determine if prophylactic antibiotics affect intra-operative culture results in patients undergoing revision hip or knee arthroplasty surgery for infection. this is a prospective randomized clinical study to determine if prophylactic antibiotics affect intra-operative culture results in patients undergoing revision hip or knee arthroplasty surgery for infection. pre-operatively, patients will have their affected joint aspirated and this fluid will be sent for cultures. patients are then randomized to receive prophylactic antibiotics (vancomycin and ancef) within one hour prior to surgery or to have pre-operative antibiotics withheld. every patient then has their affected joint cultured intra-operatively. all samples will be evaluated for the presence of aerobic bacteria, anaerobic bacteria, mycobacteria, and fungus. pre-operative and post-operative cultures in both study populations are compared to determine the effects of pre-operative antibiotics.

Eligibility criteria:
inclusion criteria: * prior arthroplasty surgery of the hip or knee * presentation to clinic with infected joint * scheduled for revision surgery exclusion criteria: * patients who have received antibiotics for any reason within 4 weeks of their pre-operative culture * infected native joints * septic patients * refusal of participation

Keywords: revision infection knee hip replacement antibiotics
prevalence of female circumcision among young women in beni-suef, egypt

Conditions: Woman Abuse

Summary: female circumcision (fc) is a deeply-rooted practice in egypt with deblitating physical and psychological consequences, however the previous two decades witnessed sincere efforts to counterfight this practice. the objective of this study is to investigate the prevalence of circumcision among young women (12-25 years) in beni-suef , egypt.

this cross-sectional study was conducted on a total of 3353young women residing urban and rural quraters in beni-suef city. data was collected usinga questionnaire that included information about the socio-demographic charcteristics of the women, their gynecological data, exposure to fc, and complaints associated with menses during the previous year.

Eligibility criteria:
inclusion criteria: * young women aged 12 to 25 years living in beni-suef city of egypt. the urban metropolitan of beni-suef city was classified according to the socioeconomic level of its quarters to low, middle, and high levels. out of each level, one quarter was selected randomly, by a card withdrawal, where households residing these quarters were chosen using a random start. for the rural villages surrounding the urban metropolitan, three villages were selected randomly; one on the road to the north, one on the road to the west, and the last one on the road tothe south. each village was clustered roughly into two sites; one to the east of the water channel and one to the west of the same water channel exclusion criteria: * women from other places in egypt.

Keywords: female circumcision, young women, dysmenorrhea,dysuria
neonatal brain ultrasound with ceus and elastography

Conditions: Neonatal Hypoxic Ischemic Encephalopathy; Neonatal Stroke; Neonatal Encephalopathy, Unspecified

Summary: the aim of our study is to investigate changes of brain perfusion and elasticity in neonates during the time that a neonate is adapting to live outside the womb and during diseases that are suspected to affect neonatal brain perfusion. we use contrast enhanced ultrasound (sulphur hexafluoride) and ultrasound-assisted elastography to evaluate the state of brain perfusion. we will study neonates recruited from the neonatal units of turku university hospital.

sonovue (sulphur hexafluoride) is a contrast agent composed of micro bubbles. it increases echogenicity of the ultrasound thus enhancing the visualisation of vessels and giving better insights into tissue perfusion. the use of sulphur hexafluoride has been approved by fda and it has been in off-label use in europe for years. sonovue is thought to be especially useful for children, because it can enhance the diagnostic capabilities of ultrasound and the examination can be performed without radiation or sedation. elastography is a method to investigate the elasticity of a tissue by tracking the shear waves generated by the ultrasound beam. also this method has been used in europe and america for years. the aim of our study is to examine cerebral hemodynamics in neonates using ultrasound of the brain, contrast enhanced ultrasound (ceus) and ultrasound-guided shear-wave elastography (us-swe). we aim to recruit four groups of infants: those with no suspected diseases affecting brain perfusion on the first days after birth and infants with either asphyctic injury, stroke or other diseases affecting central nervous system. total recruitment for different groups is 100 infants in total, during this first study phase. the recruitment period will be up to seven years if needed. the injections of sonovue will be administered through pre-existing venous cannulas. the first examination after brain injury will be done as soon as the parental consent has been given. the ultrasound examination altogether is estimated to take about 20 minutes per day. safety monitoring period is conducted after the injection. the studies will be repeated 0-4 times according to the approval of the caretakers of the child and the disease the child is affected by. ceus data will be analysed with proper software. us-swe will be measured repeatedly on both brain hemispheres and on different areas to validate the measurements.

Eligibility criteria:
inclusion criteria: * babies less than 7 months treated at the neonatal units of turku university hospital exclusion criteria: * pre-known genetic disease * difficult congenital malformations that need surgical treatment * central nervous system tumors * weight less than 2,5 kg during examination * medical history of sonovue hypersensitivity * uncontrolled systemic hypertension * systolic pulmonary artery pressure \> 90 mmhg * unstable cardiovascular state
pain clinic provides public health safety

Conditions: Social Functioning; Addiction, Substance; Safety Issues; Road Injury; Patient Compliance; Chronic Pain

Summary: chronic pain is associated with psychological disorders; which may affect a patient's socioeconomic, legal, domestic, and employment situations. this prospective observational study evaluates the impact of pain management on patients' health, social, economic, and employment status. it explores the impact of pain clinic services on patients' mental health, family health, public health, road safety, addiction situation, public safety, injury rehabilitation and employment situation.

chronic pain is associated with many behavioral or psychological disorders. the psychological disorders may have negative impact on the patient's social, economic, health, legal, domestic, relationship and employment situations. this prospective observational study evaluates the impact of pain management services on the patients' health, social, economic, and employment status. the clinical study explores the impact of pain clinic services on patients' mental health, childcare, family health, public health, road safety, addiction situation, public safety, injury rehabilitation, employment status and housing situation.

Eligibility criteria:
inclusion criteria: * adult chronic pain patients * patients with psychosocial problems exclusion criteria: * pediatric patients * patients with severe cognitive dysfunction
hexadecanal as an addon to cognitive processing therapy for ptsd

Conditions: Post Traumatic Stress Disorder (PTSD)

Summary: this rct investigates whether cognitive processing therapy, a first line treatment for ptsd, can be enhanced by the use of the odor molecule hexadecenal (hex). hex is secreted from body odor and has been shown to promotes psychological well-being and positive social interaction. for the active group hex will be diffused in the treatment room during all treatment sessions. for the control group a vehicle placebo molecule will be diffused. both therapists and patients will be blind to study condition.

in this triple blind (patient, therapist, independent evaluator) rct, 40 patients with ptsd receiving standard cognitive processing therapy will be randomized in a 1:1 ratio to receive either odorless hexadecanal molecules or odorless mineral oil molecules (control) diffused in the treatment room at all therapy sessions. inclusion criteria: age\>18 years, ptsd diagnosis according to dsm-5-tr. exclusion: bipolar, psychotic, or neurological disorders, drug abuse, any parallel psychotherapy, anosmia. primary outcome: pre-to-post treatment change in ptsd symptom severity measured by the ptsd check list for dsm-5 (pcl-5). additional outcomes: depression (phq-9), anxiety (gad-7), anger (dar-5), therapeutic alliance (wai-sf).

Eligibility criteria:
inclusion criteria: * diagnosis of ptsd according to dsm-5 * age 18 years and over * eligible for cpt treatment at the national center for traumatic stress and resilience exclusion criteria: * bipolar disorder, psychosis, neurological disorders * drug addiction * parallel psychotherapy * congenital or acquired anosmia.

Keywords: ptsd posttraumatic stress disorder hexadecanal treatment cpt cognitive processing therapy