Kornimate/medical-research-clean huggingface dataset:
connect trial of esupport online health-coach moderated support groups for multiple sclerosis

Conditions: Multiple Sclerosis

Summary: within-subject waitlist-control group design trial of esupport health-coach moderated online support group participation to address mental health needs in persons with multiple sclerosis (pwms) from historically underrepresented groups (i.e., black and latinx patients).

the purpose of this research is to see how well a new online esupport health weekly group sessions program addresses the needs and improves the mood of adults with ms. this study is focusing on improving the online esupport weekly group session program for people with ms while assessing the impact of the program, particularly for black and latinx individuals as clinical research has often not included their experience. the entire study is done remotely by computer, tablet, or smartphone with a web camera and with a stable internet connection. subjects will be enrolled into closed, private, health-coach facilitated online support groups called esupport health weekly group sessions. these sessions are hosted on esupport health's proprietary zoom-based secure hipaa-compliant telehealth platform. each group is expected to have 10 participants and will meet weekly for 12 weeks. a licensed therapist ("study coach") leads the group sessions. the company's mutual respect \& trust (mrt)-based coaching method is utilized.

Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form (icf) * able to speak, read and understand english * reside in the u.s. * willingness to enroll as a member in esupport health * stated willingness to comply with all study procedures and availability for the duration of the study * willingness to adhere to the schedule of weekly online meetings with a minimum of 50% attendance (i.e., 6 of 12 meetings) * males and females; age 18+ * self-reported diagnosis of multiple sclerosis including the date of the diagnosis (month and year) and the name of the diagnosing physician * access to necessary resources for participating in a technology-based intervention (i.e., computer or tablet with a web camera and with a stable internet connection in a private setting) and demonstrated basic ability to use a computer by completing the electronic icf completion process and meeting with the study coach via zoom telehealth secured platform at the enrollment session. * provide identification to verify name, date of birth, and address. exclusion criteria: 1. current participation in another treatment or intervention study 2. presence of a condition(s) or diagnosis, either physical or psychological that precludes participation such as significant brain injury and developmental disability 3. current suicidal intent 4. anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.

Keywords: online support group
effectiveness of human rotavirus vaccine, rotarix™ against rotavirus severe gastroenteritis (rv sge) in infants

Conditions: Rotavirus Severe Gastroenteritis

Summary: this study aims to evaluate the effectiveness of rotarix™ vaccine in the general population in singapore by monitoring the overall reduction in rv sge and also by assessing the direct protection offered by the vaccine in hospitalised infants through a case-control study.

this protocol posting has been updated following an amendment of the protocol.

Eligibility criteria:
inclusion criteria: inclusion criteria for surveillance subjects * a male or female child aged \< 60 months at the time of admission (a child becomes ineligible on the day of its fifth birthday). * subject admitted with acute ge as an inpatient to the study site during the study period. * written informed consent obtained from the parent or guardian of the subject. selection criteria for cases cases will be limited to those surveillance subjects: * who are born after 1 november 2005 (date of availability of rotarix™ vaccination in singapore), * who are aged at least 16 weeks at the time of hospital admission. * whose stool samples are tested positive for rv. selection criteria for controls all controls must satisfy the following criteria at study entry: * admitted for acute disease with non-ge causes in the same hospital as the case , with the closest admission date to the cases. * aged at least 16 weeks at the time of hospital admission. * born within a range of ± 2 weeks from the date of birth of cases. in case there is no suitable match, then the range would be extended to ± 4 weeks. * written informed consent obtained from the subject's parents/guardians. exclusion criteria: for enrolment of surveillance subjects the following criteria should be checked at the time of study entry. if any apply, the subject must not be included in the study: * the diagnoses at admission to the study site do not include acute ge. * children for whom stool samples are not available up to 48 hours after admission. * the onset of ge is after 48 hours of admission to the hospital (i.e. nosocomial ge). * children with a history of chronic and genetic diseases. for selection of cases in addition to the exclusion criteria for surveillance subjects, cases will not be selected if the following criterion applies: * subjects who had a previous episode of acute ge less than a week back i.e. recurrent ge episode. * subjects who have been already enrolled in the study. * subjects whose vaccination history could not be ascertained. for selection of controls the following criteria should be checked at the time of study entry. if any apply, the controls must not be included in the study: * child who has symptoms of ge on the day of interview of his/her parent or guardian or had an episode of ge within 14 days prior to the day of interview. * child who has been already enrolled in the study as case or control. * the onset of ge occurs after admission at the hospital. * child whose vaccination history could not be ascertained.
antimicrobial resistance rate in escherichia coli and klebsiella pneumonia : a retrospective study

Conditions: Antibiotic Reaction

Summary: antibiotics are medicines used to avoid and treat bacterial infections. antibiotic resistance is increasing to dangerous level globally.

antibiotics resistance is a global health problem.

Eligibility criteria:
inclusion criteria: 1. patients with uti 2. patients with dysuria 3. patients with loin pain exclusion criteria: 1. patients with surgery 2. patients with cancer

Keywords: antibiotics, urine, resistance
validation of the korean confusion assessment method for the intensive care unit (cam-icu)

Conditions: Critical Care

Summary: the purpose of this study is to translate and validate the cam-icu for use in the korean icu setting.


Eligibility criteria:
inclusion criteria: * older than 18 years * admitted to medical icu at seoul national university hospital longer than 24 hours exclusion criteria: * comatose or moribund state throughout the study period * preexisting neurologic problem
prospective post-market clinical follow-up study of the hbs 2 resorb mg in patients with intra- and extraarticular fractures, pseudarthroses and arthrodesis of small bones and bone fragments.

Conditions: Intraarticular Fracture; Extraarticular Fracture; Pseudarthrosis; Arthrosis

Summary: this study is a multi-centre, prospective, clinical observational study to evaluate the ce-marked hbs 2 resorb mg screws under routine conditions. the device will be used according to its intended use. the data collected for this study does only include measurements which are standard of care.


Eligibility criteria:
inclusion criteria: * patient is 18 years and older * patient is undergoing surgery with hbs 2 resorb mg * written informed consent obtained for the treatment * treatment of intra-articular and extra articular fractures and pseudarthroses of small bones and bone fragments as well as arthrodeses in the treatment of: * scaphoid fractures and scaphoid pseudarthroses * proximal radius head fractures * fractures of the radial styloid process * fractures of the ulnar styloid process * metacarpal fractures * metatarsal fractures exclusion criteria: * any not medically managed severe systemic disease * recent history of substance abuse (i.e. recreational drugs, alcohol) that would preclude reliable assessment * pregnancy or women planning to conceive within the study period * persons who are legally detained in an official institution * participation in any other medical device or medicinal product study within the previous month that could influence the results of the present study * skeletally immature * intraoperative decision to use implants other than the device under investigation

Keywords: small bone resorbable implant magnesium
effect of awareness-based stress reducatıon program applıed to parents wıth a chıld wıth autısm

Conditions: DEPRESSION; ANXIETY; STRESS; HOPELESSNESS; MİNDFULNESS

Summary: this research was planned to examine the effect of mindfulness-based stress reduction program applied to parents with autistic children on the level of depression, anxiety, stress and hopelessness.

the program applied to parents with children with autism will be carried out once a week for 60 minutes, for 8 weeks, in 8 sessions in total. the program will be conducted in face-to-face groups. sessions will be held in a suitable area in the practice area. in each 60-minute session, it is planned to be 20 minutes of narration on the subject of the session, accompanied by a power point presentation, and the remaining 40 minutes of exercise, meditation practices and sharing experiences. in the table indicating the general operation of the sessions within the scope of the research; the purpose, target, teaching method, material place, time, session content and application steps of each session will be given to the participants. awareness-based stress reduction program applied to parents with children with autism will be given to the participants in the first week, including the important points of the program, prepared by the researchers, and expert opinions will be taken.

Eligibility criteria:
inclusion criteria * being a parent of a child with autism * being literate and able to communicate in turkish exclusion criteria: * having a diagnosed mental and mental health problem * having a chronic, mental and mental health problem other than autism in a child with autism * having previously participated in a mindfulness-based stress reduction program * having another disabled child
evaluation of one day discharge after laparoscopic appendectomy for uncomplicated appendicitis in children.

Conditions: Appendicitis Acute

Summary: the aim of this study was to evaluate the value and safety of discharge of a child to home care within 24 hours after laparoscopic appendectomy for uncomplicated appendicitis to reduce the impact on the child's psyche and need for hospitalisation. baseline demographic data and intraoperative finding will be recorded. parents are given a two-page questionnaire that is completed in three cycles (immediately after discharge, daily until the first control and immediately before the first control). all data will be statistically processed using descriptive statistics.

the research would include children who underwent laparoscopic surgery due to uncomplicated acute appendicitis in the period from october 2021 to october 2023 at the clinic for pediatric surgery of the university hospital center split. after the suspicion of acute inflammation of the appendix is established, the pediatric surgeon decides on surgical treatment. recently, laparoscopic appendectomy has been performed in a standardized manner at the clinic for pediatric surgery of the clinical hospital center split. after the operation, and in the current practice, the children would stay in hospital for 2 to 4 days. as the generally known psychological aspects of changes in children's behaviour in involuntary hospital stays, and now even more pronounced due to the sars-cov-2 (severe acute respiratory syndrome coronavirus 2) covid19 virus pandemic and reduced opportunities for parents to stay with children, the main goal of this study is to evaluate and possibly reduce hospital stay to a minimum and proof that there are no complications in treatment outcomes due to shortening the length of hospital treatment. to conduct this research, parents are given a two-page questionnaire that is completed in three cycles (immediately after discharge, daily until the first control and immediately before the first control). baseline demographic data and intraoperative findings will be recorded. all data will be statistically processed using descriptive statistics.

Eligibility criteria:
inclusion criteria: * children 6 to 18 years * uncomplicated acute appendicitis treated with laparoscopic approach * children released within 24 hours exclusion criteria: * children under 6 years * complicated acute appendicitis * intraoperative complication * operated by classical approach * children needing longer hospital care and parental therapy * children with significant comorbidities that could affect treatment outcomes

Keywords: pediatric surgery one day discharge parental satisfaction questionnaire laparoscopic appendectomy
phase 3 trial to evaluate the efficacy and safety of dkp21102_b added on to dkp21102_a compared with dkp21102_a

Conditions: Dyslipidemias

Summary: phase 3 study to evaluate the efficacy and safety of dkp21102_b added on to dkp21102_a compared with dkp21102_a

phase 3 study to evaluate the efficacy and safety of dkp21102 in patients with mixed dyslipidemia where ldl-c is properly controlled but triglyceride and hdl-c levels are not regulated by dkp21102_a alone.

Eligibility criteria:
inclusion criteria: * a man or woman over 19 years old. * patients with coronary heart disease or risk of coronary heart disease exclusion criteria: * history of unstable angina, myocardial infarction etc * uncontrolled hypo-thyroidism (tsh≥1.5xuln), diabetes(hba1c ≥ 9.0%) * renal impairment (creatinine clearance \< 60 ml/min) etc.
human papilloma virus (hpv) vaccination among rural african american primary caregivers and daughters

Conditions: Human Papillomavirus

Summary: african american women living in the rural south are twice as likely as caucasian women to develop cervical cancer and die of invasive cervical cancer at a higher rate than any other racial/ethnic group in the us (1). reasons for low hpv vaccination rates among rural african americans are not well understood. hpv vaccination compliance is likely influenced by barriers to health care access, misinformation regarding vaccinations, religious beliefs related to sexual health and behaviors, and mistrust of the medical community (2, 3). because the vaccination of minors requires primary caregiver consent, vaccination commitment and compliance is strongly influenced by family beliefs and communication regarding health and sexuality. to date, little research has examined the cultural, familial, and intrapersonal influences on hpv vaccination compliance among rural african american women. this study will address these gaps in the literature and provide data needed to develop effective interventions and health promotion materials to encourage hpv vaccination among rural african american women. from a pool of approximately 800 families who are participating in ongoing longitudinal research through the center for family research at the university of georgia, the investigators will recruit 200 rural female african american youth aged 13-17 who have not received the hpv vaccine and their primary caregivers (n=200) into an observational, prospective study on vaccination commitment and compliance. the investigators hypotheses are as follows: 1. sociocultural factors that rural african americans experience, including discrimination, previous health care experience, religious beliefs, and community norms regarding hpv vaccination and adolescent sexual behavior, will forecast primary caregivers' hpv vaccination commitment and compliance for their daughters. the investigators also predict that primary caregivers' hpv-related knowledge and attitudes will mediate this association. 2. sociocultural factors will influence sexual health-related family communication and interaction, primary caregivers' and youths' hpv-related attitudes, and hpv vaccination commitment and compliance. 3. primary caregivers' attitudes, youths' attitudes, and family health communication will contribute to youths' and caregivers' vaccination commitment and compliance. 4. youths' sexual behavior will influence their attitudes, family health communication, and vaccination commitment and compliance.


Eligibility criteria:
inclusion criteria: * rural african american girls aged 13-17 * female parent or primary caregiver of participating daughter exclusion criteria: * girls can not be younger than age 13, or older than 17 * the target's female parent or primary caregiver must also live in the same household and agree to participate

Keywords: hpv african american rural
clinical trial comparing heparin and protamine fixed and titrated doses in cardiac surgery with cardiopulmonary bypass

Conditions: Cardiac Surgery; Cardiopulmonary Bypass; Anticoagulation

Summary: there are currently several schemes described for anticoagulation with heparin and its reversal with protamine during cardiac surgery with cpb. the oldest, and most used in our routine environment, is the scheme of fixed doses, in which a bolus dose of heparin at the start of cpb is established in iu/kg of body weight and the dose of protamine at the end of cpb is calculated based on the initial dose of heparin administered. these schemes do not take into account the variability inter-patients and can result in overdose or sub-doses of one or both drugs. the titration schedule of doses of heparin and protamine through the principle of dose-response curve of bull promotes individualization of dosage according to the response of each patient. this scheme has been associated with an effective reversal of the effect of heparin after cpb and with reduction of post-operatory bleeding and transfusion. the restoration of a state of anticoagulation by heparin after its reversal by protamine is called "rebound effect". it is a phenomenon explained by the recirculation of heparin stored in the reticulum-endothelial system and connective tissue, or by free residual concentration of heparin after clearance of protamine. this effect may be present for more than 6 hours of post-operatory and may contribute to increase post-operatory bleeding.

the objectives were, primarily, to compare intraoperative fixed versus titrated doses of heparin and protamine in cardiac surgeries with cpb regarding blood loss and transfusion requirements during the first 24 post-operative (po) hours. secondarily, the investigators compared continuous infusion of small doses of protamine (25mg/hour) and placebo during the first 6 po hours to neutralize heparin rebound effect. the investigators measured kttp and fibrinogen levels during the first 24 po hours and also the difference in blood loss and transfusion requirements between the groups. the study included patients from 18 to 75 years-old submitted to cardiac surgeries with cardiopulmonary bypass.

Eligibility criteria:
inclusion criteria: * patients submitted to an elective cardiac surgery with cardiopulmonary bypass * age 18 to 75 years-old exclusion criteria: * hematocrit \< 30 * inr \> 1,3 * platelets \< 100,000 * altered kttp * receiving non-fractioned heparin or low-molecular weight heparin * renal insufficiency or creatinine \> 2,0 * liver failure or altered alt/ast * von willebrands'disease, haemophilia, sepsis * use in the past 7 days of antiplatelet-therapy(ticlopidine or clopidogrel)

Keywords: heparin protamine cardiopulmonary bypass titration
effect of musical auditory training on subjects with tinnitus disorder

Conditions: Tinnitus

Summary: among the theories of tinnitus generation, there is that of central neuroplastic changes, which reports the association between changes and reorganization that occur in central auditory pathways and impacts on associated areas due to the altered neural signal. auditory training modifies these altered pathways through auditory exercises, which provoke positive neuroplasticity. musical auditory training is a proposal to stimulate auditory, cognitive and metalinguistic skills with activities focused on musicality. therefore, the objective of this study is to verify the effect of musical auditory training (mat) on the neuroplasticity of the auditory system and the perception of tinnitus disorder in young adults.


Eligibility criteria:
inclusion criteria: * individuals of both sexes aged between 18 years and 55 years; * complaint of chronic tinnitus (minimum perception of six months) unilateral or bilateral; * hearing thresholds within normal limits bilaterally or even mild sensorineural hearing loss in the four-tone average (500, 1000, 2000 and 4000hz); * annoyance score of at least four on the visual analogue scale, considered a moderate symptom discomfort; * have normality in the mini mental state examination (cognitive screening). exclusion criteria: * apparent speech, psychiatric or neurological changes; * history of head or brain trauma; * objective tinnitus (somatosensory and vascular); * present symptoms and/or diagnosis of middle ear involvement; * having started a new treatment (pharmacological or therapeutic) or having been diagnosed with a disease of any origin in the last month. * be carrying out another intervention for tinnitus during the research; * use of electronic assistive hearing devices.

Keywords: plasticidade neuronal zumbido processamento auditivo central
a study evaluating desvenlafaxine sustained release (dvs sr) in adult female outpatients with fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of this study is to evaluate if dvs sr is safe and effective in the treatment of pain associated with fibromyalgia syndrome, and if so to identify the efficacious doses.


Eligibility criteria:
inclusion criteria: - fibromyalgia diagnosed according to 1990 american college of rheumatology criteria exclusion criteria: * unstable medical or psychological conditions that would compromise the subject's safety or put the subject at greater risk during study participation * other painful conditions that may confound the diagnosis or assessment of fibromyalgia * treatment with other drugs for fibromyalgia with 14 days of study start or during the study
single dose pharmacokinetics of egalet® hydrocodone

Conditions: Pain

Summary: the purpose of the study is to evaluate the pharmacokinetic profile of different egalet® hydrocodone formulations and compare to a marketed hydrocodone drug.

outcomes: pharmacokinetic parameters and bioequivalence testing.

Eligibility criteria:
inclusion criteria: * non-smokers * ≥18 and ≤55 years of age * bmi ≥19 and ≤30.0 exclusion criteria: * clinically significant abnormalities, physical or psychological illnesses or conditions contraindicating hydrocodone treatment * history of significant abuse, dependance or addiction of alcohol, drugs or hard drugs within one year prior to screening * allergic to hydrocodone, hydromorphone, other opioids, or related drugs * use of any drugs known to induce or inhibit hepatic drug metabolism within 30 days prior to study drug administration * pregnant or breast-feeding

Keywords: hydrocodone pharmacokinetics safety & tolerability