Kornimate/medical-research-clean huggingface dataset:
sarcopenia in head and neck cancer patients treated with curative hadrontherapy

Conditions: Head and Neck Cancer

Summary: the study focuses on the impact of sarcopenia on acute and late toxicities in head and neck tumor affected patients treated with particle therapy.

to evaluate in hnc patients treated with particle therapy the impact of sp (measured by low skeletal muscle mass at the c3 vertebral body) on toxicity profile assessed according to nci's common terminology criteria for adverse events ctcae (version 5.0), defined as: * acute toxicity: within 3 months from the beginning of particle rt * late toxicity: more than 6 months after the end of particle rt. to investigate possible association between sp and nutritional

Eligibility criteria:
inclusion criteria: * all hnc histologies and stages * histological and/or radiological diagnosis of head and neck tumors * the patient is able to give consent * definitive/postoperative treatment with curative intent * age \>18 years * kps\> 80 exclusion criteria: * plurimetastiatic disease * palliative intent and re-irradiation treatments * known cases of any psychiatric and neurological diseases leading to disability (eg, manic disorder, schizophrenia etc..), which could impair compilation of questionnaires

Keywords: particle therapy head neck cancer sarcopenia hadrontherapy
course of face-to-face interactions in adults with autism

Conditions: Autism Spectrum Disorder (ASD); Neurotypical

Summary: this research explores how adults with autism make eye contact during formal and informal interactions; to what extent the nature of a conversation influences how eye contact is made in terms of length, frequency and overall presentation. also what physiological responses to eye contact are, in order to determine to what extent eye contact leads to an increased, decreased or unchanged stress level. in addition, to gain insight into the similarities and differences in how people with asd respond to eye contact of others compared to their own eye contact.

this research explores how adults with autism make eye contact during formal and informal interactions; to what extent the nature of a conversation influences how eye contact is made in terms of length, frequency and overall presentation. also what physiological responses to eye contact are, in order to determine to what extent eye contact leads to an increased, decreased or unchanged stress level. in addition, to gain insight into the similarities and differences in how people with asd respond to eye contact of others compared to their own eye contact. the research design chosen is an exploratory mixed methods study, which was developed in co-design with an expert by experience. the design consists of two parts. in the first part, the researcher will have a conversation (with a formal and informal phase, in which the subject will be given the idea that only the formal part is part of the research) with an adult with asd, during which hidden recordings of the subject's eye behavior will be made, and in addition, skin conductance and duration/frequency of the subject's eye contact will be recorded, without the subject knowing that this is intended for research into eye contact. in the second part, the researcher and subject watch the hidden recording of the subject's eye behavior, during which the subject's skin conductance will be recorded and special features of the subject, as seen by the researcher. both the arrangement of the subjects and researcher, as well as the physiological measurements, will be tested in advance.

Eligibility criteria:
inclusion criteria * neurotypical adults and adults with an asd, determined according to an internationally recognized classification system. * able to understand the instructions. * motivation to participate in research. exclusion criteria * no good command of the dutch language. * use of alcohol and/or recreational drugs during the research. * mentally too unstable to participate in the research. * familiarity with treatment in the vgz.

Keywords: eye contact autism spectrum disorder asd experiment neurotypical interaction physiology reflection
study of efficacy and safety of ginger extract compared with loratadine for treatment of allergic rhinitis

Conditions: Rhinitis,Allergic

Summary: efficacy and adverse effects of ginger extract in treating allergic rhinitis patients compared with loratadine.the double blind randomized controlled trial study was approved by the human research ethics committee of thammasat university no.1.

the double blind randomized controlled trial study. patients who meet the inclusion criteria and do not fall into any exclusion criteria will be randomly placed into the experimental group, who will receive ginger extract capsules, or the control group, who will receive loratadine for 42 days.

Eligibility criteria:
inclusion criteria: 1. patients have moderate allergic rhinitis (itching and nasal obstruction, watery nasal discharge, sneezing and congestion )with a minimum total nasal symptom score 7 point 2. these patients do not have the respiratory disease such as tuberculosis, nasal polyps. 3. these patients do not have the history of disease: heart disease, kidney disease, liver disease, epilepsy, high blood pressure and severe asthma. 4. these patients are not pregnant or breastfeeding. 5. these patients have normal bmi and vital signs. exclusion criteria: 1. those who have taken anti-coagulant and anti-platelet aggregation medications. 2. those who get serious side effects from loratadine and ginger allergy. 3. communication problems especially listening and interview.
administration of protein c concentrates in adult critically ill septic patients

Conditions: Sepsis

Summary: severe sepsis and septic shock are life threatening medical emergencies and are among the most significant challenges in critical care. case reports and case series suggest that plasma-derived protein c concentrate may improve the outcome of patients with acquired protein c deficiency. evidence has accumulated on the clinical relevance of the pc pathway in modulating overwhelming inflammation and preventing coagulation derangements, two key mediators of organ damage, and thus of mortality and morbidity, in sepsis. the experience collected through these studies shows that pc is safe, in that it is not associated with bleeding or severe allergic complications,and possibly useful, at least to improve the coagulation abnormalities brought about by sepsis. unfortunately, however, all we know comes from case series or case reports or an underpowered randomized controlled study. a randomized clinical trial, adequately powered for mortality or clinically relevant outcome, is necessary to confirm pc efficacy.the aim of this study is to demonstrate that protein c zymogen has clinically relevant implications in terms of reduction of thromboembolic events, 30 days mortality, length of intensive care and hospital stay, time on mechanical ventilation, length of icu and hospital stay. the study will also confirm that there is no bleeding concern with the use of protein c concentrates.the study drug will be administered in the intensive care unit for 72 hours and the patients observed till icu discharge. telephone followup will be performed at 30 days and at one year.


Eligibility criteria:
inclusion criteria: * written informed consent * age \> 18 years * at least one of the following 3 criteria: * venous-venous extra corporeal membrane oxygenation (ecmo) for septic adult respiratory distress syndrome (ards) * septic disseminated intravascular coagulopathy (dic) * sepsis induced organ dysfunction associated with a clinical assessment of high risk of death exclusion criteria: * previous unusual response to pc or any of their components (murine proteins and heparin) * pc administration or inclusion in other randomized protocols in the previous 30 days * do not resuscitate orders * refractory cardiogenic shock
system accuracy evaluation of karajishi contour and karajishi ts blood glucose monitoring systems following iso 15197:2013

Conditions: Diabetes

Summary: the study consists of 2 parts: the objective of part 1 of this study is the performance of a short evaluation of system accuracy for 25 subjects in order to familiarize the study personnel with the study bgms to be used during the planned evaluation of system accuracy (see idt-1416-bl (part 2)), ensure that the karajishi meters are fully functioning, assure and document the accuracy of the comparison method, evaluate and validate the processes and procedures of the study methodology. the objective of part 2 of this study is the evaluation of system accuracy following iso 15197:2013 (e), clause 6.3 in which accuracy requirements and applicable test procedures for blood glucose monitoring systems intended for self-monitoring of blood glucose by patients are stipulated. this study will be performed for karajishi contour and karajishi contour ts (manufacturer: bayer healthcare diabetes care) with 3 reagent system lots for each bgms.


Eligibility criteria:
inclusion criteria: * male or female, with type 1 diabetes, type 2 diabetes or no diabetes * for provoked blood glucose excursions due to insulin dose adjustment: male or female with type 1 diabetes or type 2 diabetes and intensified insulin therapy or insulin pump therapy. * minimum age of 18 years * signed informed consent form * legally competent and capable to understand character, meaning and consequences of the study exclusion criteria * pregnancy or lactation period * severe acute disease (at the study physician's discretion) * severe chronic disease with potential risk during the test procedures (at the study physician's discretion) * physical or mental constitution that compromises the subject's capability to participate in the study (at the study physician's discretion) * incapability of giving informed consent * \< 18 years * legally incompetent * accommodated in an institution (e.g. psychiatric clinic) * language barriers potentially compromising an adequate compliance with study procedures * dependent from investigator or sponsor * for provoked blood glucose excursions 50 - 80 mg/dl: * coronary heart disease * condition after myocardial infarction * cerebral incidence * peripheral arterial occlusive disease * hypoglycemia unawareness
max covid19- study

Conditions: COVID-19

Summary: in view of the increasing cases of covid-19 in india and the possibility of the exponential rise of the cases, this study has been designed to collect data of the healthcare workers of max hospital and the general population. our objective is to identify individuals with flu-like symptoms in suspicion of covid-19 and follow them weekly up to 8 weeks until the pandemic resolves. the data will be collected through an online questionnaire circulated via emails or whatsapp.

the primary objective of this study is to screen and identify individuals with flu-like symptoms and follow-them up weekly. in the study, baseline data will be collected online and then weekly follow up will be done with the participants for 4 weeks via opted communication method. there will be no physical contact and we are also avoiding the use of papers so as to avoid possible transmission. participation in this study will be entirely voluntary and the questionnaire will be accessible to the participants only when they mark "agree" on the form. the data collection form is available in english and hindi. the study questionnaire includes questions related to general health status, clinical symptoms, food security, and job security.

Eligibility criteria:
inclusion criteria: * indian males and females currently living in india, or * all the employees of max super speciality hospital, new delhi, india exclusion criteria: * anyone who has filled the questionnaire once per household
comparison between bioactive silica graft plus platelet rich fibrin and only platelet rich fibrin graft in intrabony defects with diabetes

Conditions: Intrabony Periodontal Defect

Summary: various regenerative procedures used for the treatment of intabony defects.the aim of this study is to compare the treatment outcome of bioactive silica graft with platelet rich fibrin vs bioactive silica graft in the treatment of intrabony defects in patients with diabetes mellitus.

platelet rich fibrin has emerged as one of the promising regenerative material.it is a second generation platelet concentrate and is defined as an autologous leucocyte-and platelet-rich fibrin biomaterial.platelet-rich fibrin membrane consists of a fibrin 3-d polymerized matrix in a specific structure ,with the incorporation of almost all the platelets and more than half of leucocytes along with growth factors.it enhance the stabilization and revascularization of the flaps and grafts. bioactive silica graft (novabone dental putty )is being used for regenerative procedures is a premixed composite of bioactive calcium -phospho-silicate particulate which is composed solely of elements that exist naturally in normal bone (ca,p,na,si,o) and an absorbable binder which is a combination of polyethylene glycol and glycerine.treatment of intrabony defects with bioactive silica graft has led to clinically and statistically significant probing depth reduction ,relative attachment level gain and radiographic osseous defect fill.

Eligibility criteria:
inclusion criteria: * two or three walled defects with relative clinical attachment loss ≥3mm probing depth≥5mm patients with known diabetes(type 2 hba1c 6 to 7.4) exclusion criteria: * one wall defects other systemically compromised patients non- compliant patients individuals allergic to medication pregnant or lactating mothers smokers
postoperative opioid and respiratory depression in opioid naive and chronic opioid patients

Conditions: Medical Complication

Summary: aim: to describe the duration of desaturation and bradypnea in postoperative opioid-naïve and chronic opioid patients. patients: 691 patients included from two previous ward (wireless assessment of respiratory and circulatory distress) projects. outcome: respiratory deviations four hours after opioid administration

aim: to describe the duration of desaturation and bradypnea in postoperative opioid-naïve and chronic opioid patients within the first four hours following opioid administration in addition to the chronic dose, using a continuously wireless monitoring system. patients: 691 patients included from two previous ward (wireless assessment of respiratory and circulatory distress) projects. continuous wireless monitoring data of peripheral tissue oxygenation (spo2) and respiratory rate (rr) was conducted in postoperative patients. data were stratified into opioid-naïve and chronic opioid patients, based on their preoperative opioid history. patients who did not receive opioids postoperatively were served as the control group. data was evaluated one hour before and four hours after opioid administration. the primary outcome was the cumulative duration of spo2 \<88%.

Eligibility criteria:
inclusion criteria: * patients from studies ward surgery observational \[gov: nct03491137\] * the control group from ward surgery randomized controlled trial \[gov: nct04640415\] exclusion criteria: * less than 30 minutes of continuous monitoring data within the 60-minute window prior to opioid administration * less than 120 minutes (\<50% of theoretical maximum) of monitoring data available during the four-hour observation period * patients who received transdermal fentanyl as postoperative opioid * patients with a baseline saturation or respiratory rate below the prespecified thresholds * patients with a bmi of ≥40 or diagnosed with copd were excluded in the analysis of spo2 \<92%

Keywords: opioid-induced respiratory depression postoperative opioid opioid-naïve patients chronic opioid patients desaturation bradypnea continuous monitoring patient safety
effects of taping on pregnancy-related back pain

Conditions: Pregnancy; Low Back Pain; Pelvic Girdle Pain

Summary: back pain during pregnancy is common with up to 90% of pregnant women experiencing either low back pain (plbp), pelvic girdle pain (pgp) or a combination of both pains. although pregnant women seek out various forms of pain relief methods such as pain medication, exercise, education, pelvic support belts, and chiropractic treatments, there is limited evidence with regards to the efficacy of these treatments. recently manual therapists, such as chiropractors, have used tape in an effort to relieve pain from musculoskeletal injuries with varying results. in the pregnant population, there have been limited studies to date on the role of taping and pregnancy-related back pain and none of this research delineates the efficacy of tape with respect to the 3 pain patterns experienced by pregnant women.

this study is a randomized control trial with 3 main parts associated. 1) initial visit: potential participants will be recruited from 2 antenatal clinics at the participating hospital. a person from the circle of care will ask if they are interested in participating in a study regarding pregnancy-related lbp. participants are pre-screened by a research investigator, if patients meet the eligibility criteria, they will be invited to participate. research personnel will explain the study in full including the rationale (per the project consent form), visit requirement, treatment protocol and follow-up. once consent is obtained, a pre-visit questionnaire will be administered while they are awaiting their antenatal appointment. 2) physical exam and treatment: following their appointment, research personnel will walk the participant to the obstetrical day unit where the chiropractor will review the consent and questionnaire, perform a brief physical exam to ensure proper stratification of pain, randomized the participant (as pre-determined by the biostatistician) and apply the appropriate taping protocol (intervention vs sham). 3) follow-up: five to 7 days later, research personnel will follow-up with the participant by phone and administer a questionnaire pertaining to their experience with the taping protocol. the total visit should take no more than 30 minute

Eligibility criteria:
inclusion criteria: * healthy females of childbearing age * currently experiencing a healthy, singleton pregnancy and are at 28 weeks of gestation or later * proficient competency in the english language exclusion criteria: * does not wish to participate * carrying multiples * inability to understand the questionnaire due to a lack of understanding of the english language * allergy to tape and/or adhesives (acrylic copolymer) * prior spinal surgery * a known and current disc pathology

Keywords: pregnancy low back pain pelvic girdle pain kinesiotape
comparison of early and late therapy for adults with operatively treated distal radius fractures

Conditions: Distal Radius Fractures

Summary: the purpose of the study is to compare two common ways of rehabilitating after surgery for distal radius fractures treated operatively with a volar plate.

over the last three decades, operative treatment of distal radius fractures has become increasingly common compared to non-operative treatment. over the last 15 years there has been a trend towards more invasive, internal plate fixation of fractures of the distal radius. one argument in favor of internal fixation for these fractures is that, similar to other periarticular fractures, it would be beneficial to allow early movement of the wrist articulation. there is not, however, any data to support this statement. in fact, data regarding external fixation that either immobilizes the wrist or allows wrist motion suggest that early wrist mobilization is not as important as the overall alignment of the bone in terms of final wrist motion. this question is important in patient care and in decision-making regarding these fractures. additionally, many companies use this claim as a marketing point in spite of the lack of evidence. we consider that good quality data is needed to determine the answer to this issue and to help to resolve the related problems described above.

Eligibility criteria:
inclusion criteria: * gender: male or female * age: older than 18 * isolated distal radial fracture * fracture treated with volar plates, stable fixation * initial treatment within 4 weeks of trauma exclusion criteria: * complex fractures that require additional or different material than volar plates * unstable fractures in which early mobilization is contraindicated

Keywords: distal radius fracture rehabilitation volar plate fixation dash questionnaire
study of clinic-based versus self-use of medical abortion pills

Conditions: Induced Abortion; First Trimester Abortion; Misoprostol; Mifepristone

Summary: the goal of the study is to determine whether important clinical outcomes differ among women who access a combined medical abortion regimen from a pharmacy when compared with those who access it from a facility.

medical abortion with mifepristone and misoprostol within the first 10 weeks of pregnancy is safe and highly effective. investigators aim to assess whether self-use of early (\<9 weeks) medical abortion using mifepristone with misoprostol results in non-inferior rates of clinical outcomes when compared with clinic-based provision of medical abortion. the investigators will prospectively recruit women who obtain medical abortion medication from pharmacies and clinics. follow-up will occur by telephone during two phone calls within 30 days following the woman's abortion. a small number of adolescents will be recruited into a qualitative substudy.

Eligibility criteria:
inclusion criteria: women are eligible for participation if they have purchased abortion medications (mifepristone-misoprostol) independently at a pharmacy or received them from a clinic for an unwanted pregnancy at less than 9 weeks since her last menstrual period (lmp). she must meet the following criteria: * be at least 15 years of age (may vary by country) * have a known lmp of less than 9 weeks * no contraindications to medical abortion (list) * willing and able to give informed consent * have a mobile phone of which they are the independent user or be willing to be followed-up in person * willing to be contacted with questions about her abortion by telephone (optional in-person visit) at 3, 10-14 and 30 days following initial contact. * resident of country of study. exclusion criteria: * contraindications to mifepristone-misoprostol * age \<15

Keywords: medical abortion self-use