Kornimate/medical-research-clean huggingface dataset:
validity and reliability of the turkish version of hande

Conditions: Scleroderma; Hand Rheumatism

Summary: the aim of the present study was to translate and cross-culturally adapt the hand scleroderma experienced experience (hande) scale into the turkish language and investigate its reliability and validity in turkish-speaking patients with systemic sclerosis.

objective: the aim of the present study was to translate and cross-culturally adapt the hand scleroderma experienced experience (hande) scale into the turkish language and investigate its reliability and validity in turkish-speaking patients with systemic sclerosis. methods: the hande was cross-culturally adapted according to beaton's guideline. participants completed the turkish version of hande scale (hande-t), the mouth handicap in systemic sclerosis scale (mhiss), 36 item short form survey (sf-36), health assessment questionnaire (haq). internal consistency of the hande-t questionnaire was evaluated by cronbach's alpha coefficient. convergent validity was tested using pearson's correlation coefficient. the construct validity of the hande-t questionnaire was assessed by factor analysis. the construct validity of the hande-t was evaluated by correlating the scores between hande-t and haq, sf-36 pcs, sf-36 mcs and mhiss scores.

Eligibility criteria:
inclusion criteria: * 1) being 18-65 years of age, * 2) being diagnosed of ssc according to do 2013 american college of rheumatology (acr) criteria and/or european league against rheumatism (eular) criteria, * 3) being literate in turkish, * 4) being agreed to participate in the research. exclusion criteria: * 1) being in a psychological or cognitive disorders that would prevent to answer questions.

Keywords: hand reliability scale validation scleroderma
real-world data study to understand effectiveness of treatments in peyronie's disease

Conditions: Peyronie's Disease

Summary: this is an observational study, meaning participants will not receive any investigational treatment as part of this study. researchers will collect real-world data (rwd) to gain a more in-depth knowledge of the treatment of peyronie's disease (pd) to evaluate the management of pd.

each participant of the study will have their data collected from the date of confirmed diagnosis of pd to the date of enrollment in the registry, post consent. data will be collected from the participant's clinical records as well as from the participant directly. data will be collected through pulse infoframe's technology platform.

Eligibility criteria:
key inclusion criteria: * any adult with a confirmed clinical diagnosis of pd. * age 18 years (or age of majority in their jurisdiction) or older at time of enrollment. * willing to participate in the registry (including completion of epros) and complete the informed consent form. * having received pd treatment within 2 weeks before enrollment, at enrollment or any time after the date of enrollment. after a confirmed diagnosis of pd, not having received pd treatment. * able to participate in english based registry. key exclusion criteria: * not having a clinical diagnosis of pd. * age less than 18 years. * do not provide informed consent.

Keywords: real world data retrospective prospective registry
manual therapy on head-repositioning accuracy and static postural balance in neck pain patients

Conditions: Neck Pain

Summary: to investigate the effect of cervical manual mobilization on head repositioning accuracy and postural balance in patients with chronic mechanical neck pain in a randomized controlled trial. hypothesis: there is no difference between the intervention group (manual mobilization) and control group head repositioning accuracy and postural balance.

the aim of the study is to investigate the effectiveness of manual therapy to standing balance and head-neck proprioception sense in patients with chronic neck pain. the study will recruit 120 chronic neck pain patients and randomize the into 2 groups of 60. group 1 will receive a course of manual therapy and infrared radiation for 15 minutes (twice weekly for 12 sessions). the other group (control) will receive infrared radiation therapy only. manual therapy will be provided by experienced physiotherapists and assessed by a separate assessor. all outcome measures will be assessed at the beginning of study, upon completion of intervention, 3-month and 6-month after the completion of study. all measurements collected will be analysed by computerized statistical software in order to calculate the effectiveness of manual therapy and relationship among those outcome measurements.

Eligibility criteria:
inclusion criteria: * aged 18 to 65 years * presented with a complaint of neck pain (defined as pain in the region from the upper thoracic spine to the occiput and the surrounding musculature) for more than 7 weeks. * had not received neck pain treatment in the past 1 month exclusion criteria: * onset of presenting neck pain episode after trauma (eg, whiplash) * history of cervical injury of trauma since the onset of presenting neck pain episode * history of cervical injury or trauma * neck pain due to fracture, tumor, infection, severe spondyloarthropathy, or other non-mechanical cause such as inflammatory arthritis; * progressive neurological deficit, myelopathy, herniated nucleus pulpous, or severe incapacitating pain; * being treated by electrical devices; * blood coagulation disorder or were using corticosteroids or anticoagulant medications; * history of stroke or transient ischemic attacks; * vertebrobasilar artery insufficiency; * neurologic disease (eg, multiple sclerosis, parkinson's disease, syringomyelia); * congenital anomalies involving the c-spine; * systemic disease (eg, diabetes mellitus); * pain involving third-party liability or workers' compensation.

Keywords: musculoskeletal manipulations proprioception postural balance
motiv82change: an hiv prevention study for young latino men

Conditions: HIV Infections

Summary: the purpose of this study is to develop and pilot test a culturally and developmentally tailored motivational enhancement intervention (mei) to reduce risky sex (unprotected anal sex and multiple partners) among young hispanic men who have sex with men (yhmsm).

stage 1, divided into stage 1a and stage 1b, focuses on development, refinement, and pilot testing of interventions. the formative research leading to and including intervention development is completed in stage 1a. a pilot study to provide acceptability/feasibility data and obtain effect size estimates of the intervention's strength in changing a desired outcome is conducted in stage 1b. if stage 1b results are "promising," the intervention moves to full scale efficacy testing in stage 2 using the classic experimental design of a randomized control trial (rct). the intervention is ready for stage 3 effectiveness testing only after its efficacy has been demonstrated in at least two stage 2 trials.

Eligibility criteria:
inclusion criteria: to be eligible, participants must: 1. be male; 2. self-identify as hispanic/latino; 3. be 18 - 29 years of age; 4. live in south florida; 5. have had at least 1 episode of unprotected anal sex with a man in the last 6 months; 6. have had at least 2 male sex partners in the last 6 months; 7. be hiv negative or not known to be hiv positive; and 8. have not previously participated in this study. exclusion criteria: 1. living with hiv infection

Keywords: hiv hiv seronegativity prevention hispanic latino msm men
rapid ventricular pacing during cerebral aneurysm surgery: a retrospective study concerning the safety for heart and brain

Conditions: Cardiac Pacing, Artificial; Aneurysm, Brain; Arteriovenous Malformations, Cerebral

Summary: rapid ventricular pacing (rvp) is a technique to obtain flow arrest for short periods of time during dissection or rupture of the aneurysm. rvp results in an adequate fall of blood pressure which presents as an on-off phenomenon. it is not clear whether repetitive periods of pacing are harmless for the patient. silent cardiac and cerebral infarcts may be undetected. the investigator will study the safety of rvp, particularly for the heart and the brain, retrograde by studying troponin levels and magnetic resonance imaging or computed tomography.

rapid ventricular pacing (rvp) is a technique to obtain flow arrest for short periods of time during dissection or rupture of the aneurysm. rvp results in an adequate fall of blood pressure which presents as an on-off phenomenon. the technique facilitates the dissection and manipulation of cerebral aneurysms and arteriovenous malformations (avms) and can be lifesaving in the case of an intraoperative bleeding or rupture. in a former study blood pressure and clinical outcome were used as study parameters. however it is not clear whether repetitive periods of pacing are harmless for the patient. silent cardiac and cerebral infarcts may be undetected if only clinical outcome is taken as a study parameter. in this retrograde study, the investigators will study the safety of rvp, particularly for the heart and the brain, using magnetic resonance imaging or computed tomography and troponin levels. the purpose of this study is to evaluate the effect of repetitive periods of rvp on the oxygenation of the heart and brain using magnetic resonance imaging and troponin levels both markers for ischemia damage.

Eligibility criteria:
inclusion criteria * elective cerebral aneurysm clipping surgery * arteriovenous malformation surgery * craniotomy * american society of anesthesiologists 1,2 and 3 exclusion criteria: * cardiac abnormalities * coronary heart disease * valvular heart disease * pregnancy
study evaluating pantoprazole in peptic ulcer hemorrhage

Conditions: Peptic Ulcer Hemorrhage

Summary: the purpose of this study is to evaluate the efficacy and safety of intravenous pantoprazole in the prevention of rebleeding in patients with bleeding peptic ulcer disease after successful endoscopic hemostatic therapy.


Eligibility criteria:
inclusion criteria: * patients must be men or non-pregnant women at least 18 years of age * patients who present with a gastric or duodenal ulcer exclusion criteria: * patients with ulcer appearance of clean base (non-oozing, non-spurting) or flat pigmented spot; adherent clots not removed by irrigation * patients presenting with active bleeding and/or nbvv at 2 or more separate sites * patients with any severe concomitant diseases, eg, end stage liver or renal disease, or unstable cardiovascular, pulmonary, renal, hepatic, or gastrointestinal diseases

Keywords: peptic ulcer hemorrhage
shoe orthotics for improvement of biomechanics and symptoms of knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: knee osteoarthritis (oa) is a widespread problem in canada, leading to decreased quality of life and increased economic burden. current research has focused on expensive, invasive treatments, whereas inexpensive conservative treatments have received less attention. one such treatment is the use of orthotics to reduce pain and increase function in people with knee oa. currently, clinical practice guidelines for the use of orthotics are vague and contradictory, and could benefit from more research taking into account foot posture. this study aims to compare the use of two orthotics designs in people with knee oa.


Eligibility criteria:
inclusion criteria: i) age 50 - 80 years (to meet the american college of rheumatology clinical definition of oa) ii) medial tibiofemoral oa, defined as medial knee pain on most days of the past month and evidence on radiographs of a definite osteophyte in the medial tibiofemoral compartment iii) pronated feet, defined as a foot posture index that is 0.5 standard deviations above the reported population mean. exclusion criteria: i) low pain score on a numerical rating scale of pain (average knee pain on walking ≤3 out of 10 over previous week) to allow detection of treatment response ii) knee surgery or intra-articular corticosteroid injection within the previous six months iii) current or recent (within 4 weeks) oral corticosteroid use iv) any muscular, joint or neurological condition affecting lower limb within the past 6 months v) ankle/foot pathology or pain that precludes the use of orthotics vi) current use of foot orthotics vii) use of footwear unable to accommodate an orthotic viii) unable to walk without a gait aid ix) inability to speak english or have a family member present to translate (required for the validity of the questionnaires)

Keywords: osteoarthritis knee biomechanics treatment symptoms
interleukin-2 (il-2), interleukin-5 (il-5) and interleukin-17 (il-17) levels of patients with stainless steel crowns

Conditions: Saliva; Dental Crown; Nickel Sensitivity

Summary: the aim of this study is to investigate whether nickel hypersensitivity following stainless steel crown treatment in children aged 3-9 leads to an increase in il-2, il-5, and il-17 levels by analyzing saliva samples. by doing so, the study seeks to prevent potential hypersensitivity reactions after stainless steel crown treatment. the main question it aims to answer is: which interleukin level increases in the controls 1 week after stainless steel crowns are applied? researchers will investigate whether there is a significant increase in interleukin levels in children's saliva before and after the procedure. participants will: they will provide saliva samples before stainless steel crowns are applied they will visit the clinic after 1 week for check-ups and tests.

expression levels of il-2, il-5 and il-17 in the saliva of individuals aged 3-9 years who underwent stainless steel crown will be recorded before and after the procedure. before the saliva sample collection procedure, the patient will be asked to rinse their mouth with sterile water and then spit into sterile plastic cups. after collecting approximately 5 ml of saliva, the saliva will be transferred to appropriate eppendorfs and stored at -40 degrees celsius. for the second post-procedure, the same algorithms will be applied for saliva collection seven days after the crown procedure. also ph value and ion levels of saliva will be measured.

Eligibility criteria:
\*\*inclusion criteria:\*\* * patients with teeth requiring stainless steel crowns due to having caries on two or more surfaces. * pediatric patients between 3-9 years old \*\*exclusion criteria:\*\* * patients having any dental materials, such as fillings, fissure sealants, root canal treatments, or space maintainers * patients with known allergies to various foods and materials. * patients with systemic diseases that affect the immune system. * patients with a history of chemotherapy or radiotherapy.

Keywords: saliva dental crown gene expression
guided imagery in the perioperative period in gynecologic oncology patients

Conditions: Uterine Cervical Neoplasms; Uterine Neoplasms; Ovarian Neoplasms; Urogenital Neoplasms; Fallopian Tube Neoplasms

Summary: the purpose of this study is to evaluate the effectiveness of self-administered perioperative guided imagery to reduce perioperative distress in gynecologic oncology patients undergoing surgical management for a presumed cancer diagnosis.


Eligibility criteria:
inclusion criteria: * undergoing surgical management for a suspected diagnosis of gynecologic malignancy (endometrial, ovarian, vulvar, vaginal, primary peritoneal, fallopian tube) * age 18 or greater * receiving care at university of michigan comprehensive cancer center gynecologic oncology clinic or at st. joseph mercy hospital, alexander cancer care center * able to understand and read english * eastern cooperative oncology group (ecog) performance status of 0-2 * patients must have working telephone, mobile or land line exclusion criteria: * severe hearing impairment that limits the ability to use audio-based guided imagery modules * current documented alcohol abuse or illicit drug substance abuse * planned outpatient surgery * patients currently participating in a meditation practice for more than 1 hour per week prior to preoperative visit.

Keywords: gynecologic cancer guided imagery postoperative distress perioperative distress
opt-in: osteopathic plagiocephaly treatment for infants and neonates

Conditions: Plagiocephaly, Nonsynostotic; Plagiocephaly, Positional; Plagiocephaly; Cranium; Deformity

Summary: the goal of this crossover randomized clinical trial is to assess the effects of osteopathic manipulative treatment (omt) compared to standard of care repositioning in children diagnosed with positional/deformational plagiocephaly. the main hypothesis is that children who received omt will show significantly improved anthropometric measures of cranial symmetry over those receiving the current pediatric standard of care of repositioning. this is a two-arm, randomized cross-over clinical trial. with parental consent, pediatric patients (infants \<4 months of age) will be organized into one of two groups: 1. those who receive omt with emphasis on osteopathic cranial manipulative medicine (ocmm) to restore cranial symmetry. 2. those who receive standard care only with repositioning attention from the parents after 8-weeks of being in the first group, each participant will cross-over into the second group (omt or repositioning) n = 122 subjects diagnosed with deformational plagiocephaly (dp) are to be recruited (to allow for natural attrition and loss to follow up) with the recruitment to continue until 61 patients have been placed in each of the two groups and will cross-over to the respective treatment group (omt and standard of care repositioning therapy). timeline: it is projected that to recruit and carry out the assessments and interventions (8-weeks of each group with 12-months of follow-up longitudinally), it will require two years (24-months) from the beginning of the study to completion.


Eligibility criteria:
inclusions: * diagnosed with positional plagiocephaly * under 4-months of age (between birth - 4 months) at the time of enrollment exclusions: * preterm birth (\<37 weeks) * genetic syndromes * craniofacial defects/deformities (e.g. cleft lip/palate) * brachycephaly/scaphocephaly * hypotonia * hypertonia * craniosynostosis * head trauma or other neurological illnesses * lost to follow up * patient whose parents (or legal guardians) disagree to attend 8-treatments of omt and 2 additional measurement sessions * prior helmet therapy, physical therapy, or omt before the date of enrollment

Keywords: positional plagiocephaly nonsynostotic plagiocephaly repositioning osteopathic manipulative treatment cranial asymetry
pembrolizumab in first-line treatment of advanced-stage classical hodgkin lymphoma

Conditions: Hodgkin Lymphoma

Summary: the primary objective of this trial is to estimate efficacy of the novel regimen. the primary endpoint is the 1-year pfs rate after treatment with one dose of pembrolizumab followed by four to six cycles of chemo-immunotherapy with p-brecadd, and pet-guided radiotherapy as per standard of care


Eligibility criteria:
main inclusion criteria: * age 18-60 * advanced stage classical hodgkin lymphoma * no previous treatment for chl main exclusion criteria: * nodular lymphocyte-predominant hodgkin lymphoma or composite lymphoma * chemotherapy or radiotherapy in medical history * prior or concurrent disease that prevents treatment according to protocol

Keywords: advanced stage first line treatment pd-1 inhibitor
enhancing substance use treatment services to decrease dropout and improve outpatient treatment utilization in emerging adults

Conditions: Substance Use Disorders

Summary: emerging adults (ages 18-25) are at higher risk for substance use disorders, including opiate addiction, than any other age group but are also more likely to drop out early from substance use treatment services. this project will evaluate an enhancement to usual services, delivered by peer recovery supports, specifically aimed at improving treatment adherence and reducing dropout in this age group. the study will also answer key questions about risk factors for dropout among emerging adults and the financial sustainability of enhancing services to reduce dropout.

emerging adults (eas; ages 18-25) have higher rates of substance use disorders than any other age group and have been hit particularly hard by the opioid crisis. eas also demonstrate poor adherence to healthcare regimens associated with substance use services, with higher dropout rates and lower service utilization than any other age group. this poor adherence leads to devastating outcomes, including continued substance use, incarceration, and overdose. in addition, high dropout rates contribute to skyrocketing costs to treatment systems as a result of more acute service needs, expensive service utilization, and long waitlists. cost-effective strategies that are aimed at improving treatment adherence to substance use services and tailored to meet the unique developmental needs of eas are an imminent need. further, little is known about risk factors for dropout specific to this age group, hindering effective system responses to this significant problem. at the same time, substance use service systems are increasingly using peer recovery supports (prs; i.e., paraprofessionals who have "lived experience" with substance use problems) to bolster treatment outcomes without incurring considerable additional costs. however, services delivered by prs have not been tailored specifically to reduce ea dropout, and few have been rigorously tested at all. the current study will evaluate an innovative ea-specific dropout prevention enhancement to usual treatment services, delivered by prs in community-based substance use treatment clinics (aim 1). the investigators will employ a stepped-wedge cluster randomized design, resulting in each clinic having a longitudinal usual services phase and a longitudinal dropout prevention phase. the two phases will be compared on rates of ea dropout and service utilization using objective data from clinical charts.

Eligibility criteria:
inclusion criteria: * 18-25 * initiating outpatient treatment for a substance use problem

Keywords: peer recovery supports emerging adults recovery support services
terminal weaning of mechanical ventilation or extubation in anticipation of death in the intensive care unit

Conditions: Withdrawal; Anxiety; Depression; Posttraumatic Stress Disorder

Summary: the purpose of the study is to assess the dying process in critically ill patients with decision to withdraw invasive mechanical ventilation in anticipation of death and to compare effects of extubation and those of terminal weaning of mechanical ventilation on relatives and care givers. the investigators primary hypothesis is that extubation is associated with less symptoms of post-traumatic stress disorders in relatives, as compared to terminal weaning.


Eligibility criteria:
inclusion criteria: * end of life decision to withdraw invasive mechanical ventilation after at least 48 hours of icu stay exclusion criteria: * age under 18 years * non invasive mechanical ventilation * brain death * death before withdrawal of mechanical ventilation * no french-speaking relative * refusal of relative to participate the study

Keywords: mechanical ventilation end of life extubation terminal weaning complicated grief