Kornimate/medical-research-clean huggingface dataset:
artificial intelligence algorithms for discriminating between covid-19 and influenza pneumonitis using chest x-rays

Conditions: COVID-19; Pneumonia, Viral; Influenza With Pneumonia; Flu Symptom; Flu Like Illness; Pneumonia, Interstitial; Pneumonia, Ventilator-Associated; Pneumonia Atypical

Summary: this project aims to use artificial intelligence (image discrimination) algorithms, specifically convolutional neural networks (cnns) for scanning chest radiographs in the emergency department (triage) in patients with suspected respiratory symptoms (fever, cough, myalgia) of coronavirus infection covid 19. the objective is to create and validate a software solution that discriminates on the basis of the chest x-ray between covid-19 pneumonitis and influenza

this project aims to use artificial intelligence (image discrimination) algorithms; * specifically convolutional neural networks (cnns) for scanning chest radiographs in the emergency department (triage) in patients with suspected respiratory symptoms (fever, cough, myalgia) of coronavirus infection covid 19; * the objective is to create and validate a software solution that discriminates on the basis of the chest x-ray between covid-19 pneumonitis and influenza; * this software will be trained by introducing x-rays from patients with/without covid-19 pneumonitis and/or flu pneumonitis; * the same ai algorithm will run on future x-ray scans for predicting possible covid-19 pneumonitis

Eligibility criteria:
inclusion criteria: * flu-like symptoms: myalgia, cough, fever, sputum * chest x-rays * covid-19 biological tests exclusion criteria: * patient refusal * uncertain radiographs * uncertain tests results

Keywords: artificial intelligence cnns covid-19 chest x-ray emergency department triage flu
optimizing counceling on feeding options of babies from mothers living with hiv

Conditions: Hiv

Summary: semi structured interviews will be performed to determine attitudes and experiences of people living with hiv and health care providers on counseling on feeding options of babies from mothers living with hiv in order to optimize counseling in the future


Eligibility criteria:
inclusion criteria: * health care provider involved in care for people living with hiv in duth hiv treatment facility or * person living with hiv + age 18-45 + prior pregnancy/desire to have children exclusion criteria: * insufficient command of dutch or english language (oral)
dose titration investigation of the pharmacokinetics of testosterone transdermal systems in hypogonadal men

Conditions: Hypogonadism

Summary: the study will evaluate the pharmacokinetics of testosterone transdermal systems at steady-state in hypogonadal men.

subjects will receive testosterone for 4 weeks. based on a single morning testosterone measurement performed at the end of week 1, the dosage can be titrated up or down to the next dose level to maintain testosterone levels in the normal range. at the end of 4 weeks of treatment, a pharmacokinetic profile for total testosterone and metabolites will be obtained.

Eligibility criteria:
inclusion criteria: * males in good general health, 18 years of age or older. * have a previously documented testosterone deficiency. * willing and able to comply with the requirements of the protocol. exclusion criteria: * have a history of intolerance to androderm or other testosterone products. * prostate specific antigen (psa) level ≥ 4.0 ng/ml * prostate cancer or severe benign prostatic hypertrophy (bph) * have significant abnormalities in the physical examination at screening. * have current dermatological disease, skin damage or blemishes. * have participated in an investigational drug study within 30 days prior to screening.

Keywords: hypogonadism testosterone hormone replacement therapy
a study for dacogen treatment in patients with myelodysplastic syndrome

Conditions: Myelodysplastic Syndrome

Summary: the purpose of this study is to evaluate the effectiveness and safety of decitabine (dacogen) intravenous injection in patients with myelodysplastic syndrome.

this is a prospective (in which the patients are first identified and then followed forward as time passes), multi-center (study conducted at multiple sites), observational study (a scientific study to make a clear and easy understanding of the cause and effect relationship) to evaluate the effectiveness and safety information of a 5 day decitabine (dacogen) regimen in patients with myelodysplastic syndrome. this study consist of 3 phases; pre-treatment phase, treatment phase and end of treatment (day 28\~61 after last administration of dacogen). the patients will receive decitabine intravenous injection 20 mg/m2 one hour once daily for 5 consecutive days for every 4 weeks. safety evaluations including adverse events and clinical laboratory tests and will be evaluated with adverse events reported for the period ranging from informed consent and during the study to the end of treatment visit including 56 days (8 weeks) after the last administration of the clinical study treatment.

Eligibility criteria:
inclusion criteria: patients diagnosed with (primary or secondary) myelodysplastic syndrome including chronic myelomonocytic leukemia (cmml) with an international prognostic scoring system more than or equal to interferon-1 * patients who have never treated with hypomethylating agent (azacitidine and decitabine) * female patients who are postmenopausal or received contraceptive operation or refrain from sexual relations. * women of childbearing potential should conduct an effective method of birth control as defined in protocol, in case of male patients who will not have a baby within 2 months after the completion of decitabine therapy exclusion criteria: * patients diagnosed with acute myelogenous leukemia (bone marrow stem cell counts exceeding 20 %) or other progressive malignant diseases * patients with active infection of virus or bacteria * patients who used to be treated with azacitidine or decitabine * patients who are hypersensitive to excipients of decitabine * patients who are pregnant and breast-feeding

Keywords: myelodysplastic syndrome dacogen decitabine epigenetic therapy hypomethylating agent
behavioral parent training for families with deaf and hard of hearing preschoolers

Conditions: Deafness; Hearing Loss; Parenting; Child Behavior

Summary: children who are deaf and hard of hearing (dhh) rarely receive behavioral interventions to prevent the long-term costly outcomes of behavior problems. this project will systematically adapt an evidence-based parent training intervention to increase its acceptability and relevance for parents of young dhh children. effectiveness of the adapted intervention and its implementation with parents of young dhh children followed in "real world" hearing healthcare clinics will be assessed.


Eligibility criteria:
inclusion criteria: * parent is age 18 or older * parent is custodial guardian of child * parent can either speak/understand english or use american sign language * parent lives in a state with an established referral network for parents of dhh children if additional services are needed * at baseline, child is between the ages of 3 and 6 years * at baseline, child lives majority of time in the parent/guardian's home * child is deaf or hard of hearing * child has used hearing aid(s), cochlear implant(s) and/or bone conduction device(s) for greater than 6 months exclusion criteria: * active child protective services case is open * parent has already accessed behavioral health services for the child * parent participated in formative research for this study
delayed or immediate local treatment of veins

Conditions: Varicose Veins Leg

Summary: varicose veins affect a majority of adult patients and cause a decreased quality of life. in recent years, standard practice has been to perform thermoablation and local phlebectomies in the same procedure. there is conflicting data on the long-term outcome of the local varicose veins; there seems to be a need for more re-interventions if the local varicosities are not treated immediately. on the other hand, the prolonged combined procedure increases procedural pain and bleeding, as well as the risk for complications from deep vein thrombosis/pulmonary embolism. this trial aims to evaluate the need for immediate treatment of local varicosities and the potential sufficiency of main trunk treatment.


Eligibility criteria:
inclusion criteria: * ultrasound verified insufficiency of great saphenous vein (gsv) * gsv diameter 5-10 mm * c2-c4 varicosities * most proximal insufficient branch in the distal thigh * written and signed informed consent exclusion criteria: * peripheral arterial disease * body mass index \>40 * lymphoedema * known allergy to sclerosant * any known coagulopathy or history of deep vein thrombosis * severe illness * pregnancy

Keywords: varicose veins, phlebectomy
an explorative trial to explore the safety, acceptability and vaginal bleeding pattern of three etonogestrel-releasing medicated intrauterine systems (study p06060)

Conditions: Contraception

Summary: this is a phase 2, randomized, active-controlled, parallel-group, multicenter, single-blind trial of three different doses of etonogestrel releasing medicated intrauterine systems (eng-mius) in healthy parous women in need for contraception. the primary trial objective is to explore safety and acceptability of three doses of an eng-releasing medicated intrauterine system (eng-mius) as compared to multiload-cu 375®.


Eligibility criteria:
inclusion criteria: * healthy female subjects in need for contraception will be selected to participate in the trial; * each subject must be \>=18 to \<=40 years of age at screening and in need for contraception; * each subject must have given birth to at least one child (gestational age \>=28 weeks); * each subject must have a uterus with a measured length between 6.0 and 9.0 cm (extremes included) from external os to fundus uteri. exclusion criteria: * a subject must not be pregnant or suspected to be pregnant; * a subject must not have had an ectopic pregnancy in the past or must not have a history or presence of predisposing factors for this condition such as salpingitis, endometritis or pelvic peritonitis; * a subject must not have a history or presence of any malignancy; * a subject must not have a history or presence of premalignant disease of the uterus or cervix, including endometrial hyperplasia, or (other) sex-steroid sensitive premalignancies; * a subject must not have an active venous thromboembolic disorder (e.g. deep vein thrombosis, pulmonary embolism); * a subject must not have a history or presence of severe hepatic disease with ast and/or alt levels of \>=3 times the upper normal limit; * a subject must not have congenital or acquired malformations or distortions of the uterus or cervix; * a subject must not have large or multiple uterine fibromyomata, or a smaller uterine fibromyoma which may interfere with the insertion of the mius/iud according to the investigator; * a subject must not have vaginal bleeding of undiagnosed etiology; * a subject must not have dysmenorrhea interfering with daily activities or menorrhagia
bedside assessment of fall risk in emergency department elders

Conditions: Accidental Falls

Summary: the purpose of this study is to assess the risk for falls among elderly emergency department (ed) patients.this study will use 2 tests of balance, the bertec balance screening test and the "up and go" test. these tests measure how steady a person is while standing, walking, and turning 180 degrees. after patients have returned home, they will be contacted at 7 days, 30 days and 6 months to determine if they have sustained a fall during these intervals in order to find out how predictive the balance tests are in determining the risk of future falls.

falls are one of the most significant health risks to older americans. in the u.s., 30-60% of community dwelling elders will fall each year.studies have found rates of serious injury among elders who fall to range from 5-24%. five percent of those who fall are hospitalized. among elders, falls cause 2/3 of the deaths due to unintentional injury, the 6th leading cause of death in this age group. additional major morbidity due to falls includes loss of independence as well as anxiety due to fear of falling. this results in limitation of function and often in a requirement for long-term care. up to 40% of nursing home admissions are due to falls or fear of falling. expenditures for fall-related injuries account for 6% of all medical expenditures in geriatric patients. several interventions have been proven effective to reduce rates of fall. implementation of these interventions requires physician appreciation of the risk for falls in individual patients. the emergency department (ed) may provide a location to identify patients at increased risk of falling. unfortunately, successful ed based studies to identify and intervene on at-risk elders have been rare and not widely reproducible. the results of these previous ed studies demonstrate that a rapid, efficient, measurable assessment of balance is required if emergency physicians are to regularly consider such factors in their care plans and disposition decisions. development of a single, simple screening test to identify ed elders at who fall may improve falls screening in the ed and prevent unnecessary morbidity and mortality by facilitating early identification and intervention.

Eligibility criteria:
inclusion criteria: * age \> 59 years * discharge from emergency department * self-reported weight \< 300 pounds * patient resides in the community or a personal care home * patients must also confirm that they are able to walk 30 feet without help of another person.they may do this with use of an assistive device. exclusion criteria: * age \<60 years * subject is incarcerated * non-english speaking * lack of ability of patient to give consent or complete the study tasks * patient resides in a nursing home or rehabilitation facility * primary evaluation by the trauma team * inability to walk 30 feet without assistance from another person
the role of circulating soluble cd74 in acute lung injury

Conditions: Acute Lung Injury; Acute Respiratory Distress Syndrome

Summary: efforts to identify circulating factors that predict severity of acute lung injury/acute respiratory distress syndrome（ali/ards） patients is unrevealing. the primary purpose of this study is to verify our hypothesis that soluble cd74 might be a potential novel ali/ards biomarker.

acute lung injury (ali) or acute respiratory distress syndrome (ards) is a devastating cause of morbidity and mortality characterized by alveolar epithelial and endothelial injury. despite recent advances in pathogenetic mechanisms and therapy strategies of ali, efforts to identify circulating factors that predict severity of ali/ards patients have been unrevealing. cd74 (also known as a major histocompatibility complex (mhc) class ii invariant chain) is a type ii transmembrane protein, recently found to be the high-affinity receptor of macrophage migration inhibitory factor (mif). mif promotes neutrophil accumulation in alveolar space via binding to cd74 expressed on the cell surface. our previous study， consistent with others, has shown that mif was highly expressed in acute lung injury (ali). in addition, we also detected highly cd74 expression in lipopolysaccharide (lps)-induced ali mouse model. recently, a circulating form of cd74 was discovered in autoimmune liver disease. similarly, we investigated the existence of soluble form of cd74 in serum and bronchoalveolar lavage fluid (balf) in ali mouse model and burn or trauma related ali patients. based on these finds, we postulated that soluble cd74 might participate in regulating lung inflammation and be a potential novel ali/ards biomarker.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of ali/ards * informed consent was obtained from either the subjects themselves or from designated surrogates before enrollment in the study. exclusion criteria: * patients who have chronic lung disease before enrollment. * patients who have severe organ dysfunction, autoimmune diseases and tumor. * women who are pregnant or breast-feeding. * patients who, in the opinion of the investigator, have any other medical condition which renders the patient unable to complete the study or which would interfere with optimal participation in the study or produce significant risk to the patient. * patients participating in or planning to enroll in another clinical trial during the time of the study.
study of ag-013736 (axitinib) as second-line treatment in patients with metastatic renal cell cancer (mrcc)

Conditions: Carcinoma, Renal Cell

Summary: to investigate objective tumor response of ag-013736 for metastatic renal cell cancer (mrcc)


Eligibility criteria:
inclusion criteria: * patients histologically diagnosed as metastatic renal cell cancer with a component of clear cell cancer. * patients who are refractory to cytokine therapy as 1st line. * patients who experienced nephrectomy. * patients with at least 1 target lesion, as defined by recist. * patients with no uncontrolled hypertension. exclusion criteria: * gastrointestinal abnormalities * current use or anticipated inability to avoid potent cyp3a4 inhibitors or cyp1a2/3a4 inducers. * active seizure disorder or evidence of brain metastases. * patients with hemoptysis.

Keywords: ag-013736 rcc phase 2
safety and efficacy study of transplantation of epcs to treat idiopathic pulmonary arterial hypertension

Conditions: Idiopathic Pulmonary Arterial Hypertension

Summary: experimental data suggest that transplantation of endothelial progenitor cells (epcs) attenuates monocrotaline-induced pulmonary hypertension in rats and dogs. in addition, clinical studies suggest that autogolous progenitor cells transplantation is feasible and safe in patients with ischemic disease. this study will investigate the feasibility, safety, and initial clinical outcome of intravenous infusion of autologous epcs in patients with idiopathic pulmonary arterial hypertension.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of idiopathic pulmonary arterial hypertension 1. in new york heart association (nyha) functional class ii to iii 2. a mean pulmonary artery pressure more than 30 mmhg on right heart catheterization 3. the ability to walk ≥50 m during a standardized 6-minute walk test exclusion criteria: * pulmonary hypertension as a result of heart disease, pulmonary disease, sleep-associated disorders, chronic thromboembolic disease, autoimmune or collagen vascular disease, hiv infection, liver disease, nyha functional class iv, major bleeding requiring blood transfusion, diabetes, renal dysfunction, and evidence for malignant diseases were excluded
trends and outcomes in laparoscopic versus open surgery for rectal cancer

Conditions: Colorectal Adenocarcinoma; Colorectal Surgery

Summary: retrospective cohort study used to analyze trends in minimally invasive versus open surgery in colorectal surgery, over time, in outcome in the laparoscopic, robotic and open surgery groups in patients receiving colorectal resections. analysis will be performed using data collected through the american college of surgeons (acs) national surgical quality improvement project (nsqip) database, a national database with deidentified data entered by trained nurse data reviewers.

perioperative outcomes in patients undergoing laparoscopic compared to open surgery have been improving, and adoption of these procedures has rapidly escalated. despite this, minimally invasive surgery in rectal cancer is more controversial now than ever before. while laparoscopy was initially limited to non-oncologic operations, it has been shown to produce equivalent oncologic outcomes as open surgery and is now a preferred technique for colon cancer resection. however, laparoscopy is technically challenging in the deep pelvis, and there is concern for adequate resection of rectal cancers. multiple clinical trials are ongoing to assess long-term oncologic outcomes in patients with laparoscopically-resected rectal cancers (acosog, alacart, color ii, corean)1-4; yet, current data examining perioperative outcomes in these patients is limited.5,6 as there are conflicting conclusions between ongoing randomized control trials about the appropriateness of laparoscopic surgery for rectal cancers, knowledge about perioperative outcomes and trends in these outcomes over time may give surgeons more information to make clinical decisions. to address this gap, the american college of surgeons (acs) national surgical quality improvement program (nsqip) database was examined to determine the prevalence of laparoscopic surgery and 30-day outcomes over a ten-year period in patients undergoing open and laparoscopic surgery for rectal cancer. using the acs-nsqip database from 2005-2016, resections for rectal cancer will be studied. the proportion of laparoscopic versus open surgeries performed will be determined by year, and 16 30-day outcomes will be studied in each group. outcomes include: death, cardiac arrest, cerebrovascular accident, myocardial infarction, pulmonary embolism, venous thromboembolism, pneumonia, prolonged ventilation, superficial or deep incisional surgical site infection, organ space infection, renal insufficiency, acute renal failure, urinary tract infection, length of hospital stay, and operating room time. multiple logistic regression will be utilized to determine the association between laparoscopic and open technique as well as odds of outcome over time.

Eligibility criteria:
inclusion criteria: * primary diagnosis of rectal cancer exclusion criteria: * emergency surgery

Keywords: colorectal cancer colorectal colorectal surgery surgical complications rectal rectal cancer
effects of filter ventilation on sensory response, smoking topography, and inhalation in current every day cigarette smokers

Conditions: Cigarette Smoker; Current Every Day Smoker

Summary: this trial examines the effects of filter ventilation on sensory response, smoking topography, and inhalation in current every day cigarette smokers. the physical design features of cigarettes directly impact their appeal by influencing cognitive and sensory perceptions. the introduction of a now common design feature, filter ventilation, has led to greater public harm than benefit because of the potential for greater toxicity while enhancing product appeal among smokers. ventilated cigarettes dilute smoke, which promotes perceptions of ?smoothness? and therefore lower health risk, contributing to the overall appeal of these products. the purpose of this study is to assess whether removing ventilation from cigarette filters lowers cigarette product appeal among smokers.

primary objectives: i. to assess the link between marketing proxies for filter ventilation (product descriptors, packaging) and risk beliefs. outline: patients smoke 5 cigarettes separated by 30 minute washout periods. between 48 hours and 1 week later, patients smoke another 5 cigarettes separated by 30 minute washout period with cressmicro topography measurement device and bioradio device for recording inhalation patterns.

Eligibility criteria:
inclusion criteria: * currently smoking daily at least 5 cigarettes per day for at least one year * primarily using factory-made filtered cigarettes with filter ventilation * fair and above physical health * fair and above mental health * not actively trying to quit smoking or planning to quit in the next 30 days * able to converse, read, and write in english * no alcohol or illegal drug use * not pregnant or breastfeeding exclusion criteria: * currently smoking daily less than 5 cigarettes per day for at least one year * using roll-your-own cigarettes or unventilated filter cigarettes * currently using any other tobacco product daily * actively trying to quit smoking or planning to quit in the next 30 days * not able to converse, read, and write in english * adults unable to consent * prisoners * poor physical health by self report * poor mental health by self report * alcohol and illegal drug use * pregnant or breastfeeding by self report