Kornimate/medical-research-clean huggingface dataset:
anatomopathology of the subscapularis and infraspinatus muscles in children with brachial plexus obstetric paralysis

Conditions: Brachial Obstetrical Palsy

Summary: popb is a consequence of the stretching of the nerve roots (c5, c6 + / c7, c8 or t1) of the brachial plexus at birth. one third of patients will have sequelae. the most common is the appearance of a deficit of passive and active mobilities in the movements in external rotation of the shoulder especially in external rotation (re) elbow to the body, despite daily rehabilitation. at present, this stiffness is attributed to an imbalance between the external rotator muscles (mainly infraspinatus) that would be atrophied and the internal rotator muscles (subscapularis, pectoralis major, latissimus dorsi) that would be slightly affected in case of no or negative re from the age of 1 year, there is a surgical indication to operate these children. at present, surgery to lift internal retractions is the only therapy used, but despite this surgery and intensive rehabilitation, in some patients mobility deficits re-occur in a few years. thus, some teams systematically perform a muscle transfer to strengthen the outer rotator muscles deficit during the initial operation. other teams (of which principal investigator is part) do this transfer only secondarily and in some patients. investigators lack objective and scientific criteria for the indication of this second muscle transfer surgery and the etiology of retractions is not clearly defined. in humans, subscapularis is innervated by the c5 and c6 roots, which are constantly affected in popb. it can be assumed that subscapularis may have an atrophy in popb patients. to date, no anatomopathological study has been performed on the internal / external rotator muscles of patients with popb that can give indications on recurrences. based on our clinical observations and literature data, the main hypothese is there is amyotrophy of subscapularis and / or infraspinatus in popb patients with shoulder stiffness.


Eligibility criteria:
inclusion criteria: * child with popb presenting a stiffness in external shoulder rotation after the age of 1 year with a surgical indication of anterior release of shoulder is asked * obligation to obtain written informed consent from parents. exclusion criteria: * patient with another neuromuscular pathology * significant traumatic history of the upper limb (fracture or surgical intervention) or any other pathology affecting the mobility of the joints of the upper limb (either on the pathological side or on the healthy side) * patient with a contraindication to surgery (precarious general condition, major coagulation disorders, anesthetic contraindication) * child over 10 years old * refusal of the patient or family

Keywords: brachial obstetrical palsy
a study of robotic assisted laparoscopic sacral colpopexy using alyte mesh

Conditions: Pelvic Organ Prolapse; Urinary Incontinence; Mesh Erosion

Summary: robotic approach to sacral colpopexy is a relatively new procedure. the literature is scarce in regard to long term outcomes. this advanced procedure is offered at morristown memorial. this protocol will review the one year outcome of patients who underwent this pocedure using a polypropylene mesh. these outcomes will incude anatomical and quality of life measures.


Eligibility criteria:
inclusion criteria: * any patient receiving robotic assisted laparoscopic sacral copopexy with polypropylene mesh * \>21 y.o exclusion criteria: * graft material other than polypropylene mesh * enrollment in another study

Keywords: uterine prolapse vaginal prolapse mesh erosion urinary incontinence bowel symptoms
weight change in pws over six months

Conditions: Weight Change, Body

Summary: this is a completely text-messaging based study and all data will be collected via surveys administered on a mobile phone. for this study, we will gather and analyze data on changes in body weight over a 6-month interval in individuals aged 12 and over. this will help us learn more about the normal variation in weight, over time, in the pws population.

the incidence and natural history of several pws symptoms are poorly defined. in this text-messaging based study we will gather and analyze data on changes in body weight over a 6-month interval, in individuals aged 12 and over. we would like to learn about the normal weight variation in the pws population. we anticipate that this study will inform future clinical trials for hyperphagia/obesity related therapies, and provide a basis for understanding how well potential therapies are working. for this study, there will be no intervention and the all data will be collected via texting.

Eligibility criteria:
inclusion criteria: participants with pws are eligible for this study. eligible pws participants must be 12 years and older. participant/legal representative of participant must have a text messaging enabled mobile phone in order to participate in the study participants must reside in the u.s. or canada - exclusion criteria:
effect of intravenous 5% dextrose infusion during recovery from anesthesia on the quality of early postoperative recovery in patients undergoing painless gastrointestinal endoscopy

Conditions: Insulin Resistance; Postoperative Nausea and Vomiting; Quality of Recovery; Dizzyness

Summary: the aim of this study was to determine the effect of intravenous infusion of 5% dextrose injection during the recovery period of anesthesia for painless gastroenteroscopy on the patient's blood glucose level, incidence of hypoglycemia and time of awakening from anesthesia, postoperative vertigo, postoperative nausea and vomiting, and quality of recovery in the early postoperative period.


Eligibility criteria:
inclusion criteria: 1. patients who meet the indications for painless gastrointestinal endoscopy and are aged 18 to 79 years. 2. the patient or his/her guardian or immediate family members gave informed consent; 3. american society of anesthesiology (asa) anesthesia risk classification ≤ grade iii. exclusion criteria: 1. patients with contraindications to sedation/anesthesia for gastrointestinal endoscopy: e.g., severe hepatic and renal dysfunction, cardiac insufficiency; 2. patients receiving chemotherapy and opioid treatment; patients with a history of sleep apnea hypoventilation syndrome; 3. intravenous nutritional support within 8 hours prior to the examination; 4. patients diagnosed with type i or type ii diabetes.

Keywords: glucose injection solution ponv
lumina : measure the effectiveness of the booklet named "comprendre les essais cliniques"

Conditions: Rheumatic

Summary: various studies have shown that many patients do not understand all the information provided by the study investigator and by the information sheet before entering a clinical research protocol. many materials has been developped in previous research, trying to improve patients' understanding. nonetheless, their effectiveness remains uncertain. the "lumina" project aims to measure the effectiveness of the booklet named "comprendre les essais cliniques" with patients included or not included in clinical trials within the clinical neurosciences - rheumatology pole of the chu de nice. the design of this study is "before/after". a questionnaire was submitted to the patients before and after reading the booklet. that method is used in order to show if there was a difference between the score obtained from the questionnaire before and after reading. this difference could reflect an improvement in patients' comprehension and, by extension, the effectiveness of the support the team developed.


Eligibility criteria:
inclusion criteria: * age \<18 * patient coming for a consultation or an hospitalization within the clinical neurosciences-rheumatology pole of the chu de nice, or companions/caregivers who helps the patients understand * patient able to read and to understand the french language, * patient included or not in clinical trials. exclusion criteria: * participants unable to read * patient unable to understand the french language
a study to assess long-term safety, tolerability and efficacy of rozanolixizumab in subjects with chronic inflammatory demyelinating polyradiculoneuropathy

Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Summary: the purpose of the study is to assess long-term safety and tolerability of weekly doses of rozanolixizumab in subjects with chronic inflammatory demyelinating polyradiculoneuropathy (cidp).


Eligibility criteria:
inclusion criteria: * subject who has completed one of the previous rozanolixizumab study(ies) that allow access to the present study (e.g. study cidp01) * female subjects of childbearing potential must agree to use a highly effective method of birth control, during the study and for a period of 3 months after their final dose of investigational medicinal product (imp) * male subjects with a partner of childbearing potential must be willing to use a condom when sexually active during the study and for 3 months after the final administration of imp exclusion criteria: * subject has any medical (acute or chronic illness) or psychiatric condition that, in the opinion of the investigator, could harm the subject or would compromise the subject's ability to participate in this study * subject has a clinically relevant active infection (eg, sepsis, pneumonia, abscess) * subject has a known hypersensitivity to any components of rozanolixizumab * subject intends to have a live vaccination during the course of the study or within 7 weeks following the final dose of rozanolixizumab * subject has an ongoing serious adverse event (sae) or a medical condition in the parent study that the investigator considers to put the subject at a significantly increased risk of participating in cidp04 * subject has any planned elective surgery due to occur during the study dosing period which in the opinion of the investigator could interfere with study procedures

Keywords: chronic inflammatory demyelinating polyradiculoneuropathy cidp ucb7665 rozanolixizumab
multimodal neuromonitoring in acute brain injury

Conditions: Acute Brain Injury

Summary: acute brain injury due to aneurysmal subarachnoid haemorrhage (sah) or traumatic brain injury (tbi) is a condition with a high mortality, and surviving patients often have permanent disabilities. multimodal neuromonitoring of intracranial pressure, brain tissue oxygen tension (pbto2), and brain energy metabolism (measured with microdialysis (md)) may help individualise the treatment of this patient group to protect the brain and potentially improve outcomes. however, there is still a significant lack of knowledge regarding the advantages and disadvantages of this type of monitoring. the present study consists of four substudies with the overall aim of examining which factors are most influential for regulating commonly measured intracerebral parameters such as oxygenation, glucose, and lactate. additionally, the influence of these of parameters on functional outcome and mortality will be explored. the individual studies are detailed below:

substudy 1: this study investigates the relationship between glucose in blood and microdialysate (md-glucose) in patients with severe traumatic brain injury (tbi) or aneurysmal subarachnoid haemorrhage (sah). substudy 2: the aim of this substudy is to examine the contribution of arterial oxygen tension (pao2) to pbto2 in patients with acute brain injury. we hypothesize that there is an association between the two parameters, that this relationship is altered in patients with concurrent intracranial hypoertension, and that a higher burden of cerebral hypoxia is associated with poor functional outcome and mortality. substudy 3: the study aims to estimate the contribution of systemic lactate to microdialysate lactate, hypothesizing that: 1. pbto2 and cerebral perfusion pressure are independent predictors of microdialysate lactate in patients with cerebral hypoxia (pbto2\<20). 2. systemic lactate is an independent predictor of microdialysis lactate in patients without cerebral hypoxia. substudy 4: the study aims to establish whether there is a predictive threshold value of md-glutamate for unfavourable functional outcome 6 months after ictus of brain injury. additionally, we aim to explore whether there is a pattern of md-glutamate that can predict episodes of neuroworsening.

Eligibility criteria:
inclusion criteria: * adult patients admitted to the neurointensive care unit at rigshospitalet, copenhagen * diagnosis of traumatic brain injury or subarachnoid haemorrhage * multimodal neuromonitoring consisting intracranial pressure, brain tissue oxygen tension, and/or cerebral microdialysis exclusion criteria: * age below 18 years * acute brain injury due to causes other than the above mentioned

Keywords: brain injury intensive care neurointensive care anaesthesiology multimodal neuromonitoring
a pilot randomised controlled trial of a health champion intervention

Conditions: Schizophrenia; Bipolar Disorder; Major Depressive Disorder

Summary: this study is a pilot rct to evaluate the effectiveness and implementation challenges of an intervention using volunteer 'health champions' matched with service users to support service their physical health goals.


Eligibility criteria:
inclusion criteria: * older than 18 years old with a serious mental illness (mood \[affective\] disorders \[f30-f39\], schizophrenia, schizotypal, delusional, and other non-mood psychotic disorders \[f20-f29\]). * currently with a community mental health team (cmht). * want to make changes to their physical health. * has capacity to give written informed consent to take part in the project. * able to provide a named care coordinator or point of contact reachable in the event of a health crisis. exclusion criteria: * • under 18 years of age * unable to give informed consent
online mindfulness therapy for pandemic fatigue and resilience in covid-19 nurses

Conditions: Mindfulness; Nurses in COVID-19; Pandemic Fatigue; Resilience

Summary: this study evaluates online mindfulness therapy's impact on pandemic fatigue and resilience in covid-19 quarantine ward nurses. sixty nurses were divided into experimental and control groups, with the experimental group receiving a 6-week online mindfulness course.

this study evaluates the effectiveness of online mindfulness therapy on reducing pandemic fatigue and enhancing resilience among nurses in covid-19 quarantine wards. using a repeated-measures quasi-experimental design, 60 nurses were divided into experimental and control groups. the experimental group participated in a 6-week online mindfulness course. outcomes were measured using pandemic fatigue and resilience questionnaires at the pre-test , three weeks and after six weeks.

Eligibility criteria:
inclusion criteria: * over 20 years old. * nurses of covid-19 dedicated wards and dedicated intensive care units. exclusion criteria: * difficulty in attending * less than 80% of the total number of online mindfulness therapy sessions

Keywords: online mindfulness covid-19 quarantine ward nurses pandemic fatigue resilience
comparison of optic nerve head and retinal nerve fiber layer parameters derived from two different methods of scan alignment

Conditions: Glaucoma

Summary: this prospective, monocentric, non-invasive clinical study is designed to measure normal structural parameters of the optic nerve head, the peripapillary retinal nerve fiber layer, and the macula using the heidelberg spectralis oct device. this study is conducted in normal, healthy volunteers and glaucoma patients. the main goal of the study is to provide an analysis of the comparability of these parameters between two different software versions and their respective method of scan centration on the optic disc center. the study will include at least 40 eyes of 40 subjects; 20 normal, healthy subjects and 20 glaucoma patients. all subjects will undergo spectralis oct imaging, biometric and ophthalmoscopic examination, and visual field testing in one single visit. total study duration (first patient first visit to last patient last visit) is anticipated to be approximately 4 weeks.


Eligibility criteria:
inclusion criteria: * able and willing to undergo the test procedures, give consent, and to follow instructions * subjects that understand the nature of the trial * signed informed consent * age : 18 years or older * for "normal subjects", "normal" means, there is no reason that would prevent imaging of the eye, therefore: * self-reported healthy eyes without prior intraocular surgery (except cataract surgery and laser in situ keratomileusis) and without clinically significant vitreal, retinal or choroidal diseases, diabetic retinopathy, or disease of the optic nerve (e.g. impacting central va or rnflt measurements as determined by the expertise of the investigator) * visual field ght within normal limits * for "glaucoma subjects": early to advanced glaucoma according to existing medical charts and visual field ght outside normal limits on at least two occasions during the testing. * refraction between +6 and -6 diopters spherical equivalent and astigmatism ≤ 2 diopters * when both eyes are eligible, one randomly selected eye will be evaluated in the analysis exclusion criteria: * vulnerable subjects (as defined in iso 14155 gcp)with the exception of employees of the site, and , if applicable, students of the respective university. staff that is directly involved in the study is excluded from participation. * subjects unable to read or write * unreliable visual field. the reliability indices should be used as guide as well as the perimetrist's notes. * unusable disc stereo photos. * inability to undergo the tests. * insufficient quality of spectralis oct images (this is not determined until after spectralis oct examination, and is an unusual circumstance). minimum requirements are: * retina completely included in image frame, * quality score ≥ 20 in the stored art mean images, and * for onh-r scan: center position error ≤ 100 μm. * note: inability of a subject to perform one of the two scan patterns or insufficient image quality in one scan pattern does not exclude the subject or eye from the study.
depiction of delayed enhancement in patients with documented myocardial infarction

Conditions: Myocardial Infarction

Summary: the purpose of this study is to determine the dose of drug which is most effective in the delineation of dead heart muscle.

this study has previously been posted by berlex, inc. berlex, inc. has been renamed to bayer healthcare pharmaceuticals, inc.bayer healthcare pharmaceuticals, inc.is the sponsor of the trial.

Eligibility criteria:
inclusion criteria: * at least 8 weeks post-documented myocardial infarction (heart attack) exclusion criteria: * history of radiation therapy to the chest * clinically unstable * any contraindication for mri
clinical assessment of age-related macular degeneration patients after early diagnosis and treatment with ranibizumab

Conditions: Age-Related Macular Degeneration

Summary: to determine if patients treated early after diagnosis of wet age-related macular degeneration can return/maintain to their baseline pre-disease bcva.

we will conduct an open label, multi-center study of naïve amd patients that are identified early upon disease progression (had a normal va, fa or oct within 4 months prior to entry) to assess if treating with ranibizumab monthly can restore all patients to their baseline vision pre-amd. recent randomized clinical trials (marina, anchor) have conclusively demonstrated that continued intravitreal therapy with ranibizumab in patients with subfoveal cnv from amd leads to stabilization of vision in over 90% of patients and improvement in vision in at least a third of the patients and has led to the approval of ranibizumab (0.5 mg) for the treatment of neovascular amd. patients will receive monthly intravitreal ranibizumab injections for 12 months (with dose holding for return to baseline/ 20/20 or better and no evidence of fluid on sd-oct or fa). all patients will have etdrs vision and sd-oct, and complete exam at each monthly visit. patients will each have a blood analysis for genetics (either during the galley study in which they converted to wet amd and entered compass or during this study).

Eligibility criteria:
inclusion criteria: * ability to provide written informed consent and comply with study assessments for the full duration of the study * age \> 50 years * naïve wet-amd within 4 months of disease onset (for galley patients) and within 3 months of disease onset for all others * patients that have lost \> 5 letters from baseline best vision * bcva 20/25-20/320 exclusion criteria: * pregnancy (positive pregnancy test) or lactation * premenopausal women not using adequate contraception. the following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an iud, or contraceptive hormone implant or patch. * any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated * participation in another simultaneous medical investigation or trial which includes an intervention (patients could be participating in a non-interventional study such as the galley study) * juxtafoveal and extrafoveal wet-amd

Keywords: amd choroidal neovascularization ranibizumab age-related macular degeneration genome
acute effect of epap and noninvasive ventilation on pulmonary function and lung regional ventilation on bariatric surgery

Conditions: Bariatric Surgery; Obesity; Physical Therapy Modalities

Summary: obesity is a non-communicable chronic disease of multifactorial, involving biological, historical, ecological, economic, social, cultural and political. currently, bariatric surgery is considered an effective method of refractory obesity treatment, and only severe obesity effective treatment that leads to reduced long-term weight. it is well documented in the literature regarding the association of abdominal surgery and the incidence of respiratory complications and its main characteristics are: atelectasis, pneumonia, respiratory dysfunction and pleural effusion. all these respiratory complications can be minimized or avoided with the use of a respiratory therapy care protocol, since the pulmonary atelectasis is considered the main cause of complications. an arsenal of resources to physical therapy lung expansion, among these, the application of positive pressure through a valve epap (expiratory positive airway pressure) and the use of noninvasive ventilation, and aims to prevent and / or improve the complications resulting from postoperative. the electrical impedance tomography (eit) is an alternate to allow assessment of the respiratory system, without suffering the same interference conditions of patients, such as pain and bed rest. tie consists of a method that measures passively regional lung ventilation. the aim of this study is to compare the effects of the application of epap and niv on pulmonary ventilation we post bariatric surgery. this is a randomized controlled trial where patients will be divided into two groups: epap and niv and assessed by spirometry, manometer and tie. the techniques will be applied in the 1st and 2nd postoperative day where they will be evaluated before, during and after the application of the techniques.


Eligibility criteria:
inclusion criteria: * patients undergoing bariatric surgery, of both sexes and aged between 20 and 50 years. exclusion criteria: * severe lung disease; * patients with congestive heart failure (nyha class iii or iv); * coronary artery disease; * presented hemodynamic instability (map \<60 mmhg) or arrhythmias during the performance of techniques, plus any contraindications to perform the bs techniques, epap and niv to consider: trauma / facial injury that prevents the attachment of the mask, extreme anxiety, hypotension and lack of patient cooperation.

Keywords: electrical impedance tomography