Kornimate/medical-research-clean huggingface dataset:
comparison between lumbar stabilization exercises and lumbar manipulation on multifidus muscle in chronic low back pain this study will investigate and compare the effect of lumbar stabilization exercises and manipulation on multifidus muscle in chronic low back pain

Conditions: Chronic Low Back Pain (CLBP)

Summary: histological and morphological changes of multifidus muscle have been reported in lumbar disc herniation (ldh), but there is scarce research comparing the efficacy of different treatment programs that can correct multifidus dysfunction in chronic low back pain (lbp) with ldh. the purpose: this study will be to investigate and compare the effect of lumbar stabilization exercises and manipulation on multifidus muscle in chronic lbp patients with ldh. subjects: sixty patients aged ranged from 45 - 65 years suffering from chronic lbp with ldh will be randomly assigned into three groups, each group includes 20 patients. method: group (a) (control group) will receive general exercises for back muscles, group (b) will receive general exercises and lumbar stabilization exercises, and group (c) will receive general exercises and lumbar manipulation (b and c experimental groups). the outcome measurements pre and post 6 weeks of treatment will be pain intensity by visual analogue scale (vas), functional disabilities by oswestry disability index (odi), lumbar repositioning by biodex system (lr), cross sectional area (csa) and the asymmetry of both sides of multifidus muscle at the fourth and fifth lumbar vertebrae by ultrasonography.


Eligibility criteria:
inclusion criteria: * the selected subjects had chronic lbp with magnetic resonance imaging (mri) evidence of disc herniation at levels of l4-l5 and/or l5-s1 diagnosed by physician (orthopedist, neurosurgeon). * a period of continuous complaints of pain for more than 12 weeks. * all patients reported an average pain level of at least 5 on a scale of 0 to 10. exclusion criteria: * acute inflammatory diseases of musculoskeletal system. * pathology or deformities of hip, knee and ankle joints. * history of surgical approach to their back or had special pathology or non spinal condition causing referred back symptoms. * patient who indicated for surgery to treat lumbar disc herniation (i.e. sever intolerable pain, motor weakness, and cannot control urine and stool). * cardiopulmonary diseases which decrease the patient's tolerance and activities. * spondylolisthesis. * diabetic neuropathy. * osteoporosis. * a recent history of vestibular disorder or inner ear infection with associated balance and coordination problems. * a history of cerebral trauma with unresolved neurosensory symptoms or neurological deficits.
efficacy of the new closure device in improving patient compliance in treatment of hypertension with valsartan+/-hydrochlorothiazide (hctz) at 6 months

Conditions: Hypertension

Summary: this study will evaluate the efficacy of the reminder device remind cap® in improving patients' compliance in the consumption of valsartan +/- hydrochlorothiazide (hctz) in the treatment of hypertension


Eligibility criteria:
inclusion criteria: * patients with hypertension that have newly started using valsartan+/-hctz exclusion criteria: * pregnancy or hypersensitivity to valsartan+/-hctz other protocol-defined inclusion/exclusion criteria may apply

Keywords: hypertension, compliance, valsartan, hydrochlorothiazide (hctz)
cartilage autograft implantation system (cais) for the repair of knee cartilage through cartilage regeneration

Conditions: Defect of Articular Cartilage; Osteochondritis Dissecans

Summary: the cartilage autograft implantation system (cais) is designed as a single surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight or low weight-bearing region. cais is indicated for the repair of articular cartilage lesions and osteochondritis dissecans (ocd) of the knee through cartilage regeneration.

the cartilage autograft implantation system (cais) is a kit of devices that utilizes morselized autologous hyaline cartilage harvested arthroscopically, affixed onto a synthetic, resorbable implant using a fibrin sealant and implanted in a single surgical procedure. the system is designed as a surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight or low weight-bearing region.

Eligibility criteria:
inclusion criteria: * a male or female 18 to 55 years of age, * has 1 or 2 focal chondral lesions, that require repair, per index knee presenting with moderate to severe knee pain. each lesion is ≤6 mm in depth and has an area of ≥1 cm2 and ≤10 cm2. arthroscopic confirmation indicates that the lesions are either a non-ocd lesion between grades i and iii (d) or an ocd lesion between grades i and iv(a) * prior failed chondral treatment is allowed if the procedure occurred \> 6 months for debridement and lavage or \> 1 year for marrow stimulation techniques. exclusion criteria: * have more than 2 chondral lesions on the index knee, * bipolar lesions on the index knee, * greater than 5 degrees of malalignment, * require bilateral surgery * have a diagnosis of clinical and/or radiographic disease of the index joint.
video-assisted anal fistula treatment (vaaft) versus fistula-tract laser closure (filac) versus conventional seton in the management of anal fistula

Conditions: Video Assisted Anal Fistula Treatment

Summary: anal fistula is a chronic inflammatory tract connecting an internal opening in the anal canal with one or more than one external openings in the perianal skin aim of the work this prospective randomized control trial, we will compare video-assisted anal fistula treatment (vaaft) and fistula laser closure (filac) and conventional seton as regards, recurrence rate as a primary outcome. secondary outcome includes; operative and post-operative data, hospital stay, pain score, healing time, return to work and continence


Eligibility criteria:
inclusion criteria: * patients of both genders aging between 18-65 years with cryptoglandular anal fistula will be included. exclusion criteria: * we will exclude patients with associated anorectal pathology such as anal fissure, hemorrhoids, rectal prolapse, neoplasm, solitary rectal ulcer, inflammatory bowel diseases, and patients on long acting corticosteroids or immunosuppressive drugs will be also excluded.
home-based action observation training for chewing and swallowing function

Conditions: Cerebral Palsy; Chewing Disease; Action Obervation Training

Summary: the goal of this clinical trial is to investigate the effects of home-based action observation training (aot) applied together with functional chewing training (fuct) on chewing and swallowing functions and feeding behavior in children with cerebral palsy (cp) who have chewing disorders. the main questions it aims to answer are: * is the application of home-based aot together with fuct effective on chewing function in children with cp? * is the application of home-based aot together with fuct effective on swallowing function in children with cp? * is the application of home-based aot together with fuct effective on feeding behavior in children with cp? within the scope of the study, children with cp will be divided into two groups as the study group and the control group. all groups will implement fuct routines, comprising 5 sets per day, 5 days a week, for 12 weeks. additionally, the study group will be included in an aot program, conducted via telerehabilitation, for 1 set per day, 3 days a week, for 12 weeks, with the guidance of a physiotherapist. all children with cp will be evaluated at the beginning, after 6 weeks, and at the end of the study.


Eligibility criteria:
inclusion criteria: * diagnosed with cerebral palsy, * age between 6 and 18, * iq level of 70 or above, * having complaints related to chewing function and inability to manage solid food intake * feeding orally. exclusion criteria: * having a neurodegenerative disease other than cerebral palsy * having additional chronic illnesses such as systemic diseases, cancer, kidney diseases, gastrointestinal system diseases, etc., that may affect nutritional status, * experiencing visual or hearing impairment, * using any medication and/or oral device that may affect chewing performance, * having received previous chewing and/or swallowing training.
an international study of the safety and tolerability of corlux for psychotic symptoms in psychotic major depression

Conditions: Major Depressive Disorder

Summary: corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress, triggering a healthy stress response. people who suffer from psychotic major depression may have unusually high levels of cortisol circulating within them or abnormal patterns of cortisol levels, overloading the stress response mechanism and causing symptoms of psychosis such as delusional thoughts or hallucinations. if corlux can keep the body's cortisol receptors from being overloaded, the stress response system may return to normal function, which may result in improvement of symptoms. the purpose of this 56 day study is to learn the safety and effectiveness of corlux in patients who have been diagnosed with psychotic major depression (pmd).


Eligibility criteria:
inclusion criteria: * are 18 to 75 years of age * have a diagnosis of major depressive disorder with psychotic features (diagnostic and statistical manual of mental disorders, fourth edition \[dsm iv\] 296.24 or 296.34) * are able to provide written informed consent. exclusion criteria: * have a major medical problem * have previously participated in a corlux (c-1073, mifepristone) clinical trial * have a history of an allergic reaction to corlux (c-1073, mifepristone).

Keywords: psychotic major depression pmd depression major depression psychosis
supraglottic jet oxygenation and ventilation for gastrointestinal endoscopy at high-altitude

Conditions: Hypoxia; High Altitude

Summary: this study aims to determine whether the use of sojv could reduce the rate of hypoxia during gastrointestinal endoscopic procedures in deeply sedated patients sedated at high altitude comparing to the supplemental oxygen administration via nasal cannula.

the participants will be randomly allocated to either sjov or nasal cannula oxygen supply in a 1:1 ratio using block randomization with variable block sizes of four or six randomized. in the nasal cannula oxygen supply group, oxygen supplementation at 2 liters min-1 is delivered via a nasal cannula. in the sjov group, sjov is conducted using a wei nasal jet tube (wnj, well lead medical co. ltd, guangzhou, china) which is connected to a manual jet ventilator (well lead medical co. ltd, guangzhou, china) via its jet port.

Eligibility criteria:
inclusion criteria: 1. 18 years or older; 2. underwent routine gastrointestinal endoscopy under procedural sedation; 3. consented to participate in this trial. - exclusion criteria: 1. infection of the upper airway; 2. anatomical abnormalities of the face, nose, and upper airway; 3. coagulopathies; 4. anticipated or known difficult airway; 5. known allergy against propofol, soybeans, and egg; 6. absence from the high-altitude environment during the past 3 months. -
3d analysis of peri-implant soft tissue with two different connection types

Conditions: Tooth Loss

Summary: objectives: assessment of dimensional soft tissues change after single tooth gap implantation with a closed healing approach and using conical and butt-joint implant-abutment connection type. material and methods: forty patients were enrolled in the study and received randomly allocated implants with conical and butt-joint implant-abutment connection type. a standard healing abutment was placed after 6 months for two weeks. the definitive screw retained crowns were manufactured in a digital workflow. the soft tissue profile was digitized using ios on following stages: pre-op, immediately, two, 7 and 14 days post-op, pre-exposure, immediately after exposure, two weeks after exposure (pre-delivery), immediately after crown delivery, 6 and 12 months after delivery. the intraoral scans were matched in the metrology software (geomagic control x). the mean maximum and mean average differences in mm were gathered to assess the soft tissues change. various anamnesis parameters have been taken into account.


Eligibility criteria:
inclusion criteria: * presence of a single tooth gap, completion of conservative and periodontal treatments, diagnostic preoperative models, and a recent panoramic radiograph not older than 6 months. exclusion criteria: * abnormal jaw anatomy, insufficient bone volume, bone conditions (e.g., cysts, tumors), oral mucosa abnormalities (e.g., lesions, diseases), untreated periodontal disease, acute inflammation, pregnancy, temporary medication contraindications, psychological issues (e.g., substance abuse), poor compliance, and general medical contraindications.

Keywords: dental implants, implant-abutment connection types, conical connection, butt-joint connection, peri-implant soft tissue, digital monitoring
influence of beta amyloid imaging on care of patients cognitive complaints.

Conditions: Alzheimer's Disease; Mild Cognitive Impairment

Summary: when older patients develop cognitive problems - like memory loss - there may be any of several underlying causes, sometimes occurring in combination. clinicians have a better chance of providing appropriate treatment if they understand what the cause of the problem is. a diagnostic tool can help the patient by helping the clinician to make a more accurate diagnosis. this study investigates whether a new diagnostic tool - beta amyloid imaging - may potentially improve medical practice. the tool can potentially improve practice only if it can influence clinical judgment. this study investigates whether the provision of beta amyloid imaging information influences clinical judgment. the investigators will conduct a survey that presents clinicians with descriptions of hypothetical older patients with cognitive complaints. some of the respondents also receive beta amyloid imaging information. the investigators will test the investigators hypothesis that the information will affect diagnostic judgment and management recommendations by comparing the responses of clinicians who receive the beta amyloid information to the responses of clinicians who do not.


Eligibility criteria:
inclusion criteria: * practicing clinicians describing their training and practice as any of the following: neurologist, geriatrician, psychiatrist. * included respondents must also attest that they are a physician who is experienced in the assessment and diagnosis of dementia.

Keywords: alzheimer's disease mild cognitive impairment neuroimaging diagnostic tool
comrade: collaborative care management for distress and depression in rural diabetes

Conditions: Type 2 Diabetes Mellitus; Diabetes-related Distress; Depression

Summary: the study will implement and evaluate, using a pragmatic comparative effectiveness trial, a unique collaborative, stepped-care intervention for patients with uncontrolled type 2 diabetes and co-morbid distress and/or depression.

the investigators plan to implement and evaluate, using a pragmatic comparative effectiveness trial, a unique collaborative, stepped-care intervention for patients with uncontrolled type 2 diabetes and co-morbid distress and/or depression. the investigators approach will combine practice-based medical and cognitive behavioral treatment with strong community-based support to immediately place the patient at the right level of intervention based on disease and severity and to step-up treatment intensity and follow-up if the initial response is inadequate. the practice-based component will use a care manager linked to medical, pharmacologic, and behavioral colleagues. the community based component will utilize community health workers to provide support and facilitate access to resources. goals include: 1) implementing and evaluating the effectiveness of this intervention; 2) examining the impact of this approach on psychological mediators of improved glycosylated hemoglobin (hba1c); and 3) building, sustaining, and disseminating a cost-effective care model.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of type 2 diabetes mellitus 2. glycosylated hemoglobin (hba1c) \> 7.0 = uncontrolled 3. positive score on diabetes related distress 2 question screener and/or 4. positive score on patient health questionnaire (phq-2) 2 question screener exclusion criteria: a diagnosis \[from billing records using international classification of disease, 9th edition (icd-9) codes\] of: 1. advanced disease (e.g., end stage renal disease, advanced heart failure, blindness, metastatic cancer and including those who are in active treatment for cancer), or 2. alcoholism or 3. cognitive impairment, or 4. major psychiatric disease or 5. any type of physical or mental impairment that would preclude active participation
regimens comparison for breast cancers of positive lymph nodes

Conditions: Breast Cancer

Summary: to compare the efficacy and safety of ec-t and et regimen as adjuvant treatment of breast cancer patients with positive lymph nodes

ec-t regimen: epirubicin 90mg/m2 day1, ctx 600mg/m2, day 1, 21 days per cycle \*4cycle. followed by paclitaxel 175mg/m2,d1,21days per cycle, 4 cycle. et regimen: epirubicin 75mg/m2 day1,paclitaxel 175mg/m2,d2,21days per cycle, 6 cycle

Eligibility criteria:
inclusion criteria: * patients with breast cancer after breast cancer surgery with positive lymph nodes age 18-70 years old exclusion criteria: * with other malignance disease

Keywords: positive lymph node
outcomes following medical or surgical management of endocarditis

Conditions: Endocarditis

Summary: infective endocarditis is a rare disease, and while there have been several large reviews of the incidence of endocarditis in the pediatric patient population, relatively little has been published regarding the short and medium-term outcomes following medical and surgical therapy for this disease. the goal is to compare the outcome for children treated for endocarditis with either medical management or surgery by looking at the success of these two treatment strategies. another goal is to attempt to identify risk factors for medical management that might identify patients who would be better served by early surgery.

after identification of qualified subjects, the families of surviving patients will be mailed a package containing a cover letter explaining the study, a consent form, an assent form if applicable, a questionnaire (designed to evaluate longer-term outcome measures including the occurrence of recurrent endocarditis, late surgical intervention or the need for re-operations) and a self addressed stamped envelope to be used to return the consents and the questionnaire. the data will then be entered into a database and analyzed.

Eligibility criteria:
inclusion criteria: * all patients discharged from children's healthcare of atlanta at egleston with a discharge diagnosis of endocarditis or those who underwent surgery with a preoperative diagnosis of endocarditis. * admitted to the hospital between january 1, 1984 - december 31, 2004, inclusive. * signed informed consent. exclusion criteria: * patients who do not have documented endocarditis based upon microbiology and echocardiography criteria.

Keywords: pediatric cardiology
an enhanced artificial intelligence breast mri interpretation system

Conditions: Breast Cancer

Summary: interpretation of breast mr images is a very time-consuming process and places a great burden on breast radiologists. this project aims to develop a technical solution that addresses this healthcare challenge by developing a system that is able to automatically interpret breast mr images in order to aid the radiologist in their diagnosis.

breast cancer is the most common type of cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2015. in the uk, one in five cases of breast cancer results in a fatality. the intelliscan project aims to develop a technological solution that addresses a significant healthcare challenge. intelliscan will develop a software system that will be able to interpret breast mr images automatically in order to identify potential breast cancers. regular mri screening of the breast is offered to women from the age of 20, who are at higher risk of developing breast cancer. mr image sequences provide a large amount of information to the radiologist and the interpretation of images is a manual process, which is very time consuming. the high number of women eligible for mri screening combined with the amount of data provided by mri scans places a great burden on healthcare systems. therefore, automatisation of this process would greatly relieve this burden and also has the potential to provide more accurate diagnoses. in this first study, the system's user interface as well as the algorithm will be developed using existing mri scans. existing mri scans with known breast anomalies will be used to develop the decision-making basis for the algorithm. the system will then be tested using existing mri scans without information about possible anomalies and results will be compared to results from the software system currently in use. in addition, the user-friendliness of the system's user interface will also be evaluated.

Eligibility criteria:
inclusion criteria: * breast mri scans * mri examinations undertaken at partner nhs trust in the uk * mri examinations undertaken on the mri system currently installed at partner nhs trust site (since 2008) exclusion criteria: * incomplete breast mri datasets * breast mri without lesions * breast lesion on mri not biopsied

Keywords: artificial intelligence magnetic resonance imaging breast cancer