Kornimate/medical-research-clean huggingface dataset:
half dose of prasugrel and ticagrelor in acute coronary syndrome (hope-tailor)

Conditions: Acute Coronary Syndrome

Summary: east asian patients will be required optimal dose of newer p2y12 inhibitors (prasugrel or ticagrelor) to determine the safer treatment and better outcome. whether lower dose of these regimens are more adequate for clinical practice in korea is unclear. therefore, the investigators aim to evaluate efficacy and safety of half dose of new oral p2y12 inhibitors in korean patients with acute coronary syndrome (acs) undergoing percutaneous coronary intervention (pci).

in recent years, newer oral p2y12 receptor blockers (prasugrel or ticagrelor) have been strong recommendations for management of patients with acs undergoing (pci). these drugs provided more profound inhibitory effects than clopidogrel, which could lead to marked reduction in ischemic events, with relatively increase in bleeding complication, specific to low body weight, especially in women and east asian patients.

Eligibility criteria:
inclusion criteria: * patients present with acute coronary syndrome undergoing primary pci. * patients receive dapt (conventional dose of p2y12 inhibitors+aspirin) at least 1 month. * patients provide written informed consent prior to enrollment. exclusion criteria: * low body weight (\<60kg). * history of transient ischemic attack or stroke. * history of upper gastrointestinal bleeding in recent 6 months. * renal dysfunction defined as serum creatinine \> 2.5 mg/dl * severe hepatic dysfunction defined as serum transaminase \> 3 times normal limit * on treatment with oral anticoagulant (vitamin k antagonists, dabigatran, rivaroxaban). * bleeding tendency. * thrombocytopenia defined by platelet \< 100,000/ml. * anemia defined by hemoglobin \< 10 g/dl. * current treatment with drugs interfering with cyp3a4 metabolism (to avoid interaction with ticagrelor): ketoconazole, itraconazole, voriconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir, and telithromycin. * known severe chronic obstructive pulmonary disease or bradycardia (sick sinus syndrome (sss) or high degree av block without pacemaker protection). * contraindication for study drugs.

Keywords: half dose newer oral p2y12 receptor inhibitors acute coronary syndrome
in-person mindfulness-based intervention for adolescents with autism spectrum disorder and their caregivers

Conditions: Autism Spectrum Disorder; Autism

Summary: adolescents with asd often have co-occurring mental health symptoms like stress, anxiety, and depression. the investigators are conducting this research study to develop interventions for adolescents with asd that will improve co-occurring mental health symptoms.

adolescents with asd and their parents will complete a 3-hour in-person screening visit to determine eligibility for the study. adolescents with asd and their caregivers will participate in an 8-week mindfulness-based group intervention that meets once weekly at sarrc in phoenix, arizona. each meeting will last approximately 2-hours. teens and parents/caregivers will have separate meetings with separate group leaders but will reunite for approximately 15-minutes as a larger group to review home practice for the upcoming week. teens and parents will each be given a free 1-year subscription to ten percent happier, a commercially available mobile app focused on mindfulness meditations. each week teens will be assigned home practice, which means we will ask participants to practice mindfulness meditation every day. the investigators will recommend specific meditations and activities to complete, but participants will have access to all mindfulness meditations on the ten percent happier app. teens and caregivers will be asked to complete questionnaires assessing things like mood, anxiety, quality of life, mindfulness in day-to-day life, and their perception of the intervention. these questionnaires will be done immediately before the intervention, immediately after completing the intervention, and at 2-month follow-up.

Eligibility criteria:
inclusion criteria: * adolescents must be ages 13 to 18 years * formal clinical or educational asd diagnosis confirmed by the study team (i.e., review of the formal diagnostic or educational report) * must be able to attend at least 7 of the 8 in-person group meetings * english speaking: adolescents and their parent/caregivers must be english-speaking because the screening and behavioral measures are in english, as well as the intervention content exclusion criteria: * non-verbal participants will be excluded to ensure test compliance and increase sample homogeneity. * participants with iq scores \<70 will be excluded because the intervention was developed for individuals without intellectual disabilities. * participants with a physical disability or co-occurring condition that may prevent participation in the weekly group meetings (e.g., selective mutism; aggressive behavior; inability to participate in a 90-minute video conference meeting each week) * participants who report active suicidal ideation
outpatient lung impedance-guided preventive therapy in patients with chronic heart failure (chf)

Conditions: Chronic Congestive Heart Failure

Summary: patients suffering from chronic heart failure (chf) are hospitalized for acute heart failure (ahf) several times a year. currently, we have no method for prediction of future developments of ahf. in our center we have investigated the monitoring of lung impedence as a predictor for future deterioration. it was found that a decrease in lung impedence of more than 15% from normal value predicts ahf development with sensitivity of 98%. in this study we try to prove the hypothesis that preventive treatment according to lung impedence value may prevent future hospitalizations for ahf and improve clinical outcome. patients recruited by year: 2011 - 50; 2012 - 25; 2013 - 35; 2014 - 30; 2015 - 50; 2016 - 5


Eligibility criteria:
inclusion criteria: * patients suffering from chf, nyha ii-iv class * lv lower than 35% to lv lower than 45% exclusion criteria: * patients with additional disease with life-expectancy of less than 2 years
airway stent modified with 3d printing for gastro-respiratory fistula involving carina and distal bronchi

Conditions: Airway Disease; Fistula Bronchial; Fistula, Gastric

Summary: in this study, the investigators used the covered metallic segmented airway stent modified with 3d printing to treat gastro-respiratory fistula involving carina and distal bronchi and aimed to determine the feasibility, efficacy and safety of this technique.


Eligibility criteria:
inclusion criteria: * patients with gastro-respiratory fistula involving carina and bronchi distal to carina based on the diagnosis by bronchoscopy , gastroscopy and ct. * the patients who could not tolerate surgery and did not have clinical improvement after conservative treatment. exclusion criteria: * severe infection * coagulation disorders

Keywords: 3d printed airway stent carina distal bronchi
upper trapezius myofascial trigger point in overhead athletes after upper trapezius muscle fatigue

Conditions: Myofascial Trigger Point Pain; Fatigue

Summary: the healthy overhead athletes with and without upper trapezius myofascial trigger point will be asked to perform a scapular elevation task until the upper trapezius muscle fatigue. the first hypothesis is that the subjects with upper trapezius myofascial trigger point will show significant difference in scapular kinematics and muscles activities when compared to subjects without upper trapezius myofascial trigger point. besides, the investigators suggest that subjects with/without upper trapezius myofascial trigger point will show significant difference in scapular kinematics and muscles activities after upper trapezius muscle fatigue, especially in subjects with upper trapezius myofascial trigger point.

the investigators will recruit healthy overhead athletes with and without upper trapezius myofascial trigger point. participants will be asked to perform a sustained scapular elevation task at their peak force until the force decrease 50 %, which indicates upper trapezius muscle fatigue. there are two purposes in the current study: (1) to compare the differences between overhead athletes with/without upper trapezius myofascial trigger point during arm elevation in scapular kinematics and muscles activities (2) to investigate the effects of upper trapezius muscle fatigue on scapular kinematics and muscles activities in overhead athletes with/without upper trapezius myofascial trigger point. the first hypothesis is that the subjects with upper trapezius myofascial trigger point will show significant difference in scapular kinematics and muscles activities when compared to subjects without upper trapezius myofascial trigger point. besides, the investigators suggest that subjects with/without upper trapezius myofascial trigger point will show significant difference in scapular kinematics and muscles activities after upper trapezius muscle fatigue, especially in subjects with upper trapezius myofascial trigger point. the outcome measurements includes scapular kinematics (upward/downward rotation, external/internal rotation, posterior/anterior tilting) and muscles activities (upper trapezius, serratus anterior, lower trapezius).

Eligibility criteria:
inclusion criteria: * 18-50 years old active overhead athletes * no symptoms in the shoulder of dominant side in the past 6 months * regularly perform overhead sports activity ≥ 3 hr/wk for more than 6 months exclusion criteria: * history of major shoulder/cervical injury or surgery in the past 6 months * experiencing shoulder pain, or participating in rehabilitation for shoulder pain in the past 6 months before the study

Keywords: upper trapezius myofascial trigger point muscle fatigue overhead athlete
mri pseudo-ct sequences for obstetrical pelvimetry.

Conditions: Obstetric Labor Complications

Summary: it is possible to perform a pelvimetry by mri as a substitute to pelvimetry by ct, hence sparing the patient from a dose of irradiation.

the principal investigator want to evaluate new mri sequences offering both an optimal contrast between mineral bone and soft tissues, and a shorter acquisition time. indeed, the recent developments of specific mri sequences to preferentially image the mineral bone (namely the zte and lavaflex 3d t1-weighted spgr sequences) allow performing pelvimetry measurements on mr images offering an optimal "pseudo ct" contrast, with an mr acquisition time that is less than 10 minutes. preliminary tests of these sequences have been carried out in our center in order to be able to implement these sequences on our clinical and research mri machines. the study team wish to undertake a study to validate the use of this rapid and non-irradiating mri approach, with the aim to replace a ct pelvimetry by a mri pelvimetry demonstrated as being as reliable.

Eligibility criteria:
inclusion criteria: * pregnant woman 33 to 41 week * woman who gave birth by cesarean section, for whom the obstetrician requests a pelvimetry ct for the next pregnancy * pelvimetry planned by the obstetrical team outside of "emergency" pathway * adhere to the study protocol after reading the patient information document have signed the informed consent form to participate in the study exclusion criteria: * usual contraindications to mri (pacemaker, metallic foreign body, cochlear implant,...) * severe claustrophobia * uncomfortable back position

Keywords: technological progress
randomized minima stem with delta tt or delta st-c

Conditions: Osteoarthritis, Hip

Summary: this study is aimed to provide a clinical and radiographic evaluation of 120 suitable subjects who underwent a total hip arthroplasty with minima stem coupled with delta tt or delta st-c cup.

this is a post-market, interventional, prospective, randomized, not comparative, open label study designed to reflect real life clinical practice as closely as possible.

Eligibility criteria:
inclusion criteria: * both genders * any race * a diagnosis in the target hip of one or more of the following: a) non-inflammatory degenerative joint disease such as osteoarthritis, avascular necrosis; b) rheumatoid arthritis; c) post-traumatic arthritis; d) fractures of femoral neck; * patien willingness to partecipate and signature of informed consent form exclusion criteria: * local or systemic infection * septicaemia * persistent acute or chronic osteomyelitis * confirmed nerve or muscle lesion compromising hip joint function * vascular or nerve disease affecting the concerned limb * poor bone stock (for example due to osteoporosis) compromising the stability of the implant * metabolic disorders which may impair fixation and stability of the implant * any concomitant disease and dependence that might affect the implanted prosthsis * metal hypersensitivity to implant materials * required revision of previous standard femoral stem * women of childbearing potential who are pregnant, nursing, or planning to become pregnant, and those who do not agree to remail on an acceptable method of birth control throughout the entire study period * life expectancy less than 5 years
ultrasound assessment for comparison of gastric residual volume after ingestion of carbohydrate drink and water in obesity class ii and iii volunteers at risk of aspiration

Conditions: Obesity; Gastroesophageal Reflux

Summary: the goal of this clinical trial is to compare gastric residual volume between drinking a carbohydrate drink and water in obesity class ii and iii volunteers at risk of aspiration.


Eligibility criteria:
inclusion criteria: * bmi ≥ 35 kg/m2 (obesity class ii and iii) * gastroesophageal reflux disease and/or active gastroesophageal reflux symptoms in 6 months (heartburn and/or acid regurgitation) * asa status i-iii * npo for 8 hours before the study exclusion criteria: * chronic kidney disease or end-stage renal disease * diabetes mellitus * use of any medication that affects gastric secretion or emptying within the past 24-hour * pregnancy * history of major upper gastrointestinal surgery * allergy to ultrasound gel

Keywords: carbohydrate drink gastric residual volume gastric ultrasound
effect of consuming beans for one month on blood lipids, satiety, intake regulation and body weight

Conditions: Overweight; Obesity; Metabolic Syndrome; Diabetes; Hypertension

Summary: this project investigates the effect of regular consumption of commercially available processed white beans (5 cups per week) on food intake, body weight, blood pressure, satiety hormones and glycemic response over a 4-week period. we have chosen to provide participants with canned white beans, the most accessible and frequently consumed bean in north america. they are inexpensive, a good source of high quality nutrients and ready to eat. based upon published literature and short-term studies conducted in our laboratory, we hypothesize that regular consumption of commercially available canned beans will increase satiety and improve the control of food intake, body weight, blood glucose and blood lipids.

the metabolic syndrome is a clustering of chronic disease risk factors, including abdominal obesity, dyslipidemia, elevated blood pressure and elevated fasting blood glucose. a main treatment for metabolic syndrome is lifestyle modification (alterations in diet and/or physical activity patterns) resulting in weight loss. beans are easily incorporated into the diet and may lead to the attainment and maintenance of healthy a body weight and improved metabolic control. canned baked navy beans (with tomato sauce) have a low glycemic response following consumption, however, whether this effect has long-term benefits on glycemic control requires further investigation. objective to determine the effect of consuming 5 cups per week of commercially available canned navy beans over 4 weeks on risk factors associated with the metabolic syndrome. subjects inclusion criteria: men and women (n=16) between 35 and 55 years of age with a body mass index (bmi) of 27 to 40 kg/m2. exclusion criteria: smoking or any major surgery/medical condition within the last 6 months, use of medications that could interfere with the study outcomes, gastrointestinal, liver or kidney disease and women who were pregnant/lactating

Eligibility criteria:
inclusion criteria: * bmi 27-40 kg/m2 exclusion criteria: * smokers and individuals who have prescribed medications over the past 6 months that could interfere with the study outcomes (i.e. statins, metformin). breakfast skippers, those on a restricted energy diet or pregnant/lactating women

Keywords: beans pulses satiety appetite obesity overweight diabetes metabolic syndrome hypertension blood glucose insulin cholesterol hdl ldl leptin glp-1 adiponectin peptide yy diet
"cataract surgery in eyes with epiretinal membrane"

Conditions: Epiretinal Membrane; Pseudophakic Cystoid Macular Edema; Irvine-Gass Syndrome; Cataract

Summary: the purpose of the study is to evaluate retinal thickness change and the occurrence of central structural retinal changes after uneventful small-incision cataract surgery in eyes with asymptomatic early stages of epiretinal membrane.

optical coherence tomography (oct) is nowadays used in daily clinical practice and has become a helpful tool for detection of macular changes also in presence of opacification of the lens before cataract surgery. using recent high-resolution oct technology, early stages of epiretinal membranes can easily be detected and analysed. since cataract surgery is one of the most frequently performed operations worldwide, this study was aimed to investigate the influence of uncomplicated cataract surgery on central retinal thickness and the incidence of structural and morphological macular changes after surgery in eyes with asymptomatic epiretinal membrane.

Eligibility criteria:
inclusion criteria: * visually compromising cataract and asymptomatic early stages of epiretinal membrane with no structural changes such as cysts or photoreceptor distribution in optical coherence tomography. exclusion criteria: * visual impairment or metamorphopsia due to epiretinal membrane * history of branch retinal vein occlusion * central retinal vein occlusion * wet or dry macular degeneration * diabetic retinopathy * uveitis or other inflammatory eye disease.

Keywords: central retinal thickness epiretinal membrane cataract surgery pseudophakic cystoid macular edema
behavioral activation for smoking cessation in ptsd

Conditions: Tobacco Dependence; PTSD

Summary: the purpose of this study is to examine whether behavioral activation as an adjuvant to standard smoking cessation treatment improves smoking cessation outcomes among veterans with ptsd relative to a comparably intense combination of standard smoking cessation treatment + health and smoking education. it is expected that behavioral activation will produce more successful results than health and smoking education when paired with standard smoking cessation treatment.

the purpose of this study is to examine whether behavioral activation as an adjuvant to standard smoking cessation treatment improves smoking cessation outcomes among veterans with ptsd relative to a comparably intense combination of standard smoking cessation treatment + health and smoking education. it is expected that behavioral activation will produce more successful results than health and smoking education when paired with standard smoking cessation treatment. after an initial phone screen, in-person screening, and baseline assessment, enrolled participants will be randomized to either behavioral activation therapy and standard smoking cessation treatment (ba+st) or health and smoking education and standard smoking cessation treatment (hse+st). both groups will meet with a therapist once a week for 8 weeks to receive either ba+st or hse+st. participants' mood and smoking outcomes will be monitored throughout the 8 weeks of treatment and at 2 follow-up visits and 2 follow-up phone calls.

Eligibility criteria:
inclusion criteria: * report smoking an average of 10 or more cigarettes daily for at least six months * report a desire to quit smoking * meet criteria for current ptsd * speak and read english * agree to participate in the study * be 18 years old * be a veteran exclusion criteria: * meeting criteria for psychotic or bipolar disorder * psychoactive substance abuse or dependence (excluding nicotine dependence) within the past 6 months * inability to give informed, voluntary, written consent to participate * current use of any pharmacotherapy for smoking cessation not provided by the researchers during the quit attempt * use of non-cigarette tobacco products as a primary form of tobacco use * being currently suicidal or homicidal * being medically unable to use the nicotine patch or nicotine gum/lozenge * psychotropic medication changes within 3 months of study initiation and during active treatment * current engagement in evidence-based therapies for ptsd or depression * pregnant or trying to become pregnant * incarceration

Keywords: tobacco dependence ptsd behavioral activation therapy
to evaluate an mri-based optimized prostate cancer diagnostic pathway powered by artificial intelligence

Conditions: Prostate Cancer

Summary: it is a prospective paired-cohort study for diagnostic test evaluation. the study aim to determine the accuracy of ai review and investigate whether ai review could detect mri visible significant cancer as effective as radiologist review. mri image of about 368 men recommended for biopsy will be reviewed by an ai model and an experienced radiologist, respectively. ai review (index) and radiologist review (standard) will be blinded to each other, while biopsy urologists will be well-informed of the findings of both ai review and radiologist review and make personalized biopsy plan by combining both findings. the pathological results of mri-ultrasound fusion biopsy (reference) will serve as the gold standard to assess the diagnostic accuracy.

prostateai is a prospective paired-cohort study for diagnostic test evaluation. prostateai will determine the accuracy of ai review and investigate whether ai review could detect mri visible significant cancer as effective as radiologist review. mri image of about 368 men recommended for biopsy will be reviewed by an ai model and an experienced radiologist, respectively. ai review (index) and radiologist review (standard) will be blinded to each other, while biopsy urologists will be well-informed of the findings of both ai review and radiologist review and make personalized biopsy plan by combining both findings. the pathological results of mri-ultrasound fusion biopsy (reference) will serve as the gold standard to assess the diagnostic accuracy.

Eligibility criteria:
inclusion criteria: * patients recommended for prostate biopsy for diagnosis or re-assessment. * men at least 18 years or over * patients with prostate mri image eligible for radiologist review and ai review. * patient informed consent is signed. exclusion criteria: * patient contraindicated to prostate biopsy * patient failed to complete the biopsy procedure