Kornimate/medical-research-clean huggingface dataset:
exploration of neuroimaging and biochemical prognostic indicators for pocd

Conditions: Postoperative Cognitive Dysfunction; Cognitive Impairment

Summary: postoperative cognitive dysfunction (pocd) may lead to serious consequences. but the underlying mechanisms are still unclear. blood oxygen level dependent (bold) fmri and biochemical indicators will be used to explore the underlying mechanisms and represent a promising precursory target for diagnosis and treatment of pocd.

postoperative cognitive dysfunction (pocd) is one of the most common complications in patients undergoing cardiac surgery. pocd will not only increase the incidence of complications and mortality, but also influence the quality of life after discharging from the hospital. many factors are associated with pocd, such as neuroinflammation, age, anesthetics, surgery stress response and genetic factors. but the underlying mechanisms are still unclear. blood oxygen level dependent (bold) fmri, which could monitor the peripheral neuron spontaneous activity according to the ratio of oxyhemoglobin and deaeration hemoglobin in blood, will be used to investigate whether pocd is induced by the variance in neurons metabolism and spontaneous activity in brain regions. meanwhile, biochemical indicators will be detected to explore the prompting indicators of pocd. the present study is aimed to represent a promising precursory target for diagnosis and treatment of pocd, and provide novel evidence and insights on the brain changes induced by pocd.

Eligibility criteria:
inclusion criteria: * aged 18-80 years old * underwent selective cabg surgery exclusion criteria: * history of central nervous system or psychiatric disorders * history of taking sedative, antidepressants, or alcoholism * mmse score less than 23 * visual or auditory disorders * educated less than 7 years * claustrophobia * can not be supine * can not tolerate iodinated contrast agents

Keywords: inflammation coronary artery bypass graft magnetic resonance imaging
the effect of depth of anesthesia as measured by bispectral index (bis) on emergence agitation in children

Conditions: Emergence Agitation

Summary: the purpose of this study is to determine whether depth of anesthesia has an effect on emergence agitation (ea) in children age 2 - 8 years old. ea is a common problem in pediatric patients who receive general anesthesia with inhaled anesthetics, and the effect of depth of anesthesia on ea has not been studied. the study will randomize 40 children undergoing ophthalmologic surgery under general anesthesia to either light anesthesia (bis 55-60) or deep anesthesia (bis 40-45). ea will be measured by the peak pediatric assessment of emergence delirium (paed) score in the recovery room, which rates agitation behaviors on a scale of 0 - 20. the hypothesis is that light anesthesia is associated with more ea.


Eligibility criteria:
inclusion criteria: * children age 2 - 8 (inclusive) undergoing ophthalmologic surgery * american society of anesthesiology (asa) physical status 1 or 2 exclusion criteria: * surgery precluding placement of bis monitor * non-english speaking, until additional language consent forms are approved * previous history of severe emergence agitation

Keywords: emergence delirium bispectral index depth of anesthesia
spot-check noninvasive hemoglobin (sphb) clinical validation of invsensor00026

Conditions: Anemia

Summary: the primary objective of this clinical investigation is to evaluate the accuracy of using masimo's invsensor00026 pulse co-oximeter and sensor to measure hemoglobin, as compared to hemoglobin measurements obtained from various lab analyzer(s) and point of care device(s).


Eligibility criteria:
inclusion criteria: * 18 years of age or older * subject has given written informed consent to participate in the study exclusion criteria: * (\*) pregnant or positive human chorionic gonadotropin (hcg) test * (\*) any severe coagulopathy, chronic bleeding disorders (i.e., hemophilia) or recent thrombolysis * (\*) hemoglobinopathies and synthesis disorders (i.e., sickle cell, thalassemias, etc.) * (\*) subjects who are currently taking anticoagulant medication * (\*) subjects with allergies to lidocaine, pain ease, latex, adhesives, or plastic * (\*) subjects with skin abnormalities at the planned application sites that may interfere with sensor application, per directions-for-use (dfu) or trans-illumination of the site, such as psoriasis, eczema, angioma, burns, scar tissue, substantial skin breakdown, nail polish, acrylic nails, infections, abnormalities, etc. * (\*) subjects unlikely to be able to refrain from excessive motion during data collection. excessive motion includes postural changes, making hand gestures, involuntary muscular movements, etc. * (\*) subjects with elevated blood pressure, skin or wrist abnormalities that may interfere with an arterial blood draw as determined by investigator or research medical staff. * (\*) subjects who intend on participating in heavy lifting, repetitive movement of their wrist (including riding a motorcycle) or exercise (working out, riding a bike, etc.), or any activity that will put additional stress on the wrist within 24 hours following a study involving an arterial blood draw * subjects deemed not suitable for the study at the discretion of the investigator or research medical staff note: (\*) may be self-reported by subject
galantamine in the treatment of post-traumatic headache

Conditions: Post-Traumatic Headache; Head Trauma,Closed; Retention Disorders,Cognitive

Summary: most patients with cpth present with additional major cognitive, behavioral and somatic problems. most drugs used currently have a negative influence on cognition. therefore, treatment strategies addressing both the headache and cognitive disturbances in patients with cpth are necessary. (cpth; chronic post traumatic headache).

headache is the most common symptom after a closed head injury, persisting for more then 2 months in 60% of the patients. cpth is an important cause of consultations in neurology offices and headache clinics, posing a severe burden and affecting the quality of life of sufferers.

Eligibility criteria:
inclusion criteria: age range 18-75 cpth according to ichd-2 fertile woman using adequate birth control willing and able to give informed consent willing and able to complete the entire course of the study to comply with study instructions stable does of preventive medication - exclusion criteria: subject is pregnant or lactating significant medical or psychiatric disease previous failure to 4 or more adequate trials of preventive medication patient on non-stable dose of medication used to prevent cpth -

Keywords: post traumatic headache cognitive
surgery of the pilon fractures

Conditions: Pilon Fractures; Fractures; Bone; Leg Injuries

Summary: the assessment consists in comparing the osteosynthesis plate with minimally invasive technique versus open reduction and internal fixation. the aim of study is to compare (period of bandage, efficacy, safety), these two types of surgical technique by using a prospective, randomized analysis.

several surgical techniques exist and among plate osteosynthesis, there is a minimally invasive method and the open reduction method. investigators think that the minimally invasive method with intern plate is more efficient than the open reduction method. these techniques may better preserve perifracture soft tissues, hematoma. it may lead to a smaller muscle detachment. the minimally invasive technique allows a more efficient vascularization of the fracture site, what would increase bone healing and the functional prognosis of tibial pilon lesions. it's all these issues investigators would like to assess with a randomized study.

Eligibility criteria:
inclusion criteria: * more than 18-year-old with opened or closed pilon fracture cauchoix type 1, * signed patient consent exclusion criteria: * open pilon fracture cauchoix type 2 or 3, * infection of the operating site, * previous osseous disease * patient who are unwilling or unable to give consent

Keywords: pilon fractures osteosynthesis mini invasive plate osteosynthesis locked plate open reduction
the effect of progressive relaxation exercises by nursing students before clinical practice

Conditions: Healthy; Stress; Exercise

Summary: aim: we conducted this randomized controlled study to determine the effect of progressive relaxation exercises practiced by first year nursing students before clinical practice on their perceptions of stress, psychological resilience and meaning of life. background: progressive relaxation exercises has a positive effect on the person's mental/general health, life satisfaction and psychological well-being and enables the person to cope with stress. design: in this experimental randomized and controlled study including a control group, we administered a pre-test, post-test one and post-test two to the participating students. methods: we are planning the study with 40 first year nursing students in the intervention group, and 40 first year nursing students in the control group. the students in the intervention group took part in eight sessions of progressive relaxation exercises for four weeks, twice a week. we used the student introduction form, perceived stress scale, brief psychological resilience scale and meaning and purpose of life scale to collect the study data.


Eligibility criteria:
inclusion criteria: who did not have any diagnosed psychiatric diseases, who had not done progressive relaxation exercises and / or did not have any clinical experience previously were included exclusion criteria: who withdrew from the study at any stage, those who did not participate in the exercise sessions regularly those who used another relaxation method during this period, those who took antidepressants, those who were unwilling to participate in the study, those who lost one of their loved ones in the last 6 months were excluded from the research.

Keywords: progressive relaxation exercises nursing students
continuous activity monitoring during fractionated radiotherapy in patients with head and neck, lung, or gastrointestinal cancer

Conditions: Digestive System Carcinoma; Head and Neck Carcinoma; Lung Carcinoma

Summary: this pilot research trial studies continuous activity monitoring during fractionated radiotherapy in patients with head and neck, lung, or gastrointestinal cancer. this study explores the use of fitness trackers to study the activity levels of patients before, during, and after radiation therapy and the use of weekly assessments to measure the patients' quality of life during radiation therapy. this may allow doctors to see if there is any relationship between activity levels, quality of life, treatment interruptions, hospitalizations, and clinical outcomes.

primary objectives: i. to demonstrate the feasibility of continuous, accelerometer-based evaluation of patient activity levels before, during, and after treatment with fractionated external beam radiotherapy. secondary objectives: i. to demonstrate the feasibility of performing weekly quality of life assessments during fractionated external beam radiotherapy. ii. to explore how accelerometer-based metrics change throughout patients' treatment courses and if these changes are associated with quality of life assessments, treatment interruptions, hospitalizations, and clinical outcomes. outline: patients wear an activity monitor throughout and up 4 weeks after completion of radiation therapy. patients who are willing may continue to wear the monitor through routine follow up appointments. patients also complete questionnaires at evaluations, which take place prior to radiotherapy initiation, weekly during radiotherapy, and then 2 and 4 weeks after the completion of radiotherapy.

Eligibility criteria:
inclusion criteria: * eastern cooperative oncology group (ecog) performance status 0-2 * able to ambulate independently (without the assistance of a cane or walker) * diagnosis of invasive malignancy of the head and neck region, lung, or gastrointestinal tract * planned treatment with fractionated (\>= 15 treatments) external beam radiotherapy with concurrent chemotherapy with curative intent * women of childbearing potential must: * have a negative serum or urine pregnancy test within 72 hours prior to the start of study therapy * agree to utilize an adequate method of contraception throughout treatment and for at least 4 weeks after study therapy is completed * be advised of the importance of avoiding pregnancy during trial participation and the potential risks of an unintentional pregnancy * all patients must sign study specific informed consent prior to study entry
diagnosis by comprehensive cardiovascular imaging for stroke and tia

Conditions: Stroke; Transient Ischaemic Attack

Summary: stroke affects over 125,000 people each year in the uk and leaves at least 50% disabled. after a first stroke, there is a significant risk of recurrence (around 5-10% over the first year). while there are benefits from addressing general risk factors such as exercise, weight and smoking, selecting the best treatments for preventing a further stroke depends on understanding the underlying mechanism. most strokes results from a blood clot causing a blockage in a blood vessel in the brain ("ischaemic" strokes, about 85% of cases). the clot may originate in the heart, the major blood vessels supplying the head, or result from disease of the small blood vessels in the brain itself (around 25% of cases each), and in around 25% of people a cause cannot be determined (sometimes because more than one exists). different treatments are given depending on cause (for example, anticoagulant medication for clots from the heart, surgery for some arising from large arteries in the neck). current investigations involve multiple tests spread across different hospital departments, and commonly take several weeks to be completed. this may contribute to a high rate of strokes of uncertain cause, and may delay the start of the best treatment. this trial will investigate the value of a single comprehensive scan to look at the heart and major blood vessels (using ct scanning) in a pilot study, comparing the classification of causes of stroke and the time to starting treatments with routine care, in a randomised study of patients with recent stroke or transient ischaemic attack (tia, a short-lived stroke episode).


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ischaemic stroke or tia * male or non-pregnant female≥18 years of age. * informed consent. exclusion criteria: * known impaired renal function precluding contrast computed tomography (ct). * contraindications to mri scans * known severe hypersensitivity to iodine based contrast media for ct or gadolinium based contrast agents for mri. * severe concurrent medical condition that would prevent participation in study procedures (e.g. severe pulmonary oedema or severe septicemia) or with life expectancy ≤ 1 months.
enucleation of pancreatic tumor by blocking abdominal trunk and superior mesenteric artery

Conditions: Tumor of Pancreas; Surgical Blood Loss

Summary: pancreatic enucleation could preserve more healthy pancreatic tissues and functions with a low recurrence risk. however, conventional enucleation can cause significant intraoperative bleeding, especially in which tumors in the pancreatic head, neck, and uncinate process of pancreas, as these tissues are rich in blood supply, mainly including the abdominal trunk and the superior mesenteric artery. in this study, we developed a novel method to control the pancreatic blood flow in laparoscopic enucleation--blocking the abdominal trunk and superior mesenteric artery with vascular occlusion clips in the process of resection, and evaluated its effectiveness and safety.

between march 2023 and may 2026, patients who underwent laparoscopic pancreatic enucleation by blocking both the abdominal trunk and superior mesenteric artery in the second affiliated hospital of zhejiang university would be included in our prospective study. inclusion criteria: 1) benign or borderline tumors diagnosed pathologically, such as pancreatic neuroendocrine tumors, solid pseudopapillary tumors, and cystadenomas, without vascular invasion or distant metastasis;.2) tumors sited in the pancreatic head, neck, and uncinate process of pancreas; 3) blockade of both the abdominal trunk and superior mesenteric artery in the laparoscopic enucleation. exclusion criteria:1) highly malignant pancreatic tumors, or tumors with infiltration or metastasis; 2) tumors of the body and tail of the pancreas;3) transfer to lpd or laparotomy. patient characteristic including clinical, biochemical and radiological data will be recorded and analyzed. all patients will provide written informed consent before inclusion.

Eligibility criteria:
inclusion criteria: * benign or borderline tumors diagnosed pathologically, such as pancreatic neuroendocrine tumors, solid pseudopapillary tumors, and cystadenomas, without vascular invasion or distant metastasis * tumors sited in the pancreatic head, neck, and uncinate process of pancreas * blockade of both the abdominal trunk and superior mesenteric artery in the laparoscopic enucleation exclusion criteria: * highly malignant pancreatic tumors, or tumors with infiltration or metastasis * tumors of the body and tail of the pancreas * transfer to lpd or laparotomy

Keywords: enucleation pancreatic tumors blood loss the abdominal trunk superior mesenteric artery
microwave ablation in mild axillary hidradenitis suppurativa

Conditions: Hidradenitis Suppurativa; Acne Inversa

Summary: with microwave ablation (mwa), using the heat generated from electromagnetic waves in the microwave energy spectrum, hair follicles and apocrine glands in the (hypo)dermis are ablated through thermolysis. mwa was recently approved for the treatment of axillary hyperhidrosis (miradry) and removal of axillary hair (mirasmooth). by permanent removal of hairs and sweat glands, the investigators hypothesize a beneficial and long-term sustainable preventive effect of mwa in hs patients.

hidradenitis suppurativa (hs) is a chronic, inflammatory skin disease of the hair follicle, and is predominantly located in the axillary, inguinal and anogenital regions. current treatment options for hs include systemic oral antibiotics, anti-tnfα, and surgery, which are used to treat the consequences rather than treating the primary pathogenesis of hs. with microwave ablation (mwa), using the heat generated from electromagnetic waves in the microwave energy spectrum, hair follicles, eccrine and apocrine glands in the (hypo)dermis are ablated through thermolysis. mwa was recently approved for the treatment of axillary hyperhidrosis (miradry) and removal of axillary hair (mirasmooth). by permanent removal of hairs and sweat glands, the investigators hypothesize a beneficial and long-term sustainable preventive effect of mwa in hs patients.

Eligibility criteria:
inclusion criteria: * adult (≥ 18 years of age) male or female patients with mild hs and able to participate, willing to give written informed consent and to comply with the study restrictions; * minimum of 3 an-count located in each axilla; * maximum of 5 an-count located in each axilla. exclusion criteria: * patients with \>1 abscesses or draining fistulas per axillary region; * an-count ≥ 5 in other regions than the axillary area; * any current and / or recurrent clinically significant skin condition in the treatment area other than hs; * surgical scars covering more than 25% of each individual axillary area; * open surgical wound(s) in the axillary areas prior to randomization; * use of anti-inflammatory or immunomodulatory medication (intralesional corticosteroids, oral antibiotics, biologics, prednisone) within 2 weeks prior to randomization; * contraindication for miradry therapy; * heart pacemakers and other electronic device implants; * supplemental oxygen; * resistance to or history of intolerance of local anesthesia including lidocaine and epinephrine; * previous use of miradry therapy or mwa in the axillary area; * previous use of successful laser or light therapy for hair removal in the axillary area; * use of botulinum toxin injections 6 months prior to randomization; * use of aluminiumhydroxychloride 1 month prior to randomization; * pregnant or lactating women at randomization.

Keywords: microwave ablation hair follicle sweat gland
body weight growth after birth and bronchopulmonary dysplasia

Conditions: Bronchopulmonary Dysplasia; Preterm

Summary: bronchopulmonary dysplasia (bpd) is one of the most common, complex, and severe diseases in preterm infants. bpd was first described as chronic pulmonary disease in survivors of severe respiratory distress syndrome (rds) in 1967, which was also called as the "old" bpd. in recent years, the definition for bpd has developed a lot. the national institute of child health and human development (nichd) workshop in 2018 assessed bpd at 36 post-menstrual age (pma) along with radiographic confirmation and used a severity grading of i-iii. although with effective surfactant supplement and oxygen support, bpd brings a great challenge to neonatologists.

besides persistent inflammation, prolonged invasive ventilation and oxidative damage. body weight is the one of the most important factors to induce bpd. poor extrauterine growth is commonly described in extremely preterm infants. but, the relationship of postnatal growth with bpd and respiratory morbidity is not entirely understood. the aim of the present study is to assess whether body weight growth after birth is the risk factor for bpd.

Eligibility criteria:
inclusion criteria: * equal to or less than 32 weeks' gestational age exclusion criteria: * main congenital malformation * parents' refusal