Kornimate/medical-research-clean huggingface dataset:
spinal manipulation and dry needling versus conventional physical therapy in patients with sacroiliac dysfunction

Conditions: Sacroiliac Joint Dysfunction

Summary: the purpose of the research project is to compare the effectiveness of non-thrust mobilization and exercise versus thrust manipulation and dry needling in patients with sacroiliac dysfunction. physical therapists commonly use both approaches to treat sacroiliac joint dysfunction, and this study is attempting to determine if one approach is more effective than the other.

patients with sacroiliac pain will be randomized to receive 1-2 treatments per week for 6 weeks (up to 10 sessions total) of either: 1. high-velocity, low-amplitude (hvla) thrust manipulation and dry needling group, or 2. conventional physical therapy (stabilization, force closure, motor control exercises and manual therapy) group.

Eligibility criteria:
inclusion criteria: 1. patient must report sacroiliac dysfunction, defined as: * pain of any duration (acute, subacute, or chronic) in the fortin region (the pain may also project to the groin, thigh, lower leg and/or foot; however, it may only be local fortin region pain in some subjects). * pain does not centralize with repeated movements or sustained postures * a minimum of 3 positive pain provocation tests using either the laslett et al. (2003, 2005) or van der wurff et al (2006) multi-test regiments: * 3 or more of the following 6 pain provocation tests (laslett et al, 2003, 2005): * posterior thigh thrust * gaenslen's test (right) * gaenslen's test (left) * asis distraction * asis compression * sacral compression 2. a minimum pain rating of 2/10 using the nprs (numeric pain rating scale 0---10) 3. a minimum odi score of 10/50 (i.e. 20% minimum on oswestry disability index) exclusion criteria: 1. cauda equina syndrome 2. neurologic presentation consistent with upper or lower motor neuron dysfunction due to spinal involvement (ie myelopathy or nerve compression, hyperreflexia, pathologic reflexes, depressed or absent reflexes in the lower extremities, motor weakness involving major muscle groups of lower extremity, unsteady gait, diminished or absent pin prick sensation in the legs and/or feet) 3. spinal fractures 4. currently pregnant 5. co-existing medial problems / comorbidities (e.g., severe osteoporosis, tumors, inflammatory or infectious conditions, diabetes, angina, severe hypertension, ra, etc.) 6. involvement in litigation of worker's compensation claim for low back 7. physical therapy or chiropractic treatment for low back pain in the 3 months before initial examination 8. any indication that might contraindicate spinal manipulative therapy. 9. recent surgery to the lumbar or thoracic spine.
idiopathic central precocious puberty and associated neurodevelopmental syndromes and pathologies: evaluation of frequency and comparison of diagnostic and developmental characteristics

Conditions: Central Precocious Puberty (CPP)

Summary: observational, retrosopective, single-centre, non-profit study focused on the frequency of central precocious puberty idiopathic, or associated to neurodevelopmental syndromes and pathologies, and comparison of diagnostic and developmental characteristics of patients.

the study enrolls both male and female patients referred to the pediatrics unit of the irccs azienda ospedaliero-universitaria policlinico di sant'orsola between 01/01/2013 and 31/12/2023 for central precocious puberty and treated with gnrh analouge. the primary aim of the study is to assess the frequency of diagnosis of idiopathic or syndromic central precocious puberty in the last decade. the secondary aims are to compare clinical, laboratory and instrumental characteristics at diagnosis and in follow-up between patients with idiopathic and syndromic ppc, and to identifying possible pathogenetic factors characterising different forms of central precocious puberty.

Eligibility criteria:
inclusion criteria: * patients diagnosed with central precocious puberty presenting an indication to undertake treatment with gnrh analogue: appearance of secondary sexual characteristics (thelarche or gonadarche) before the age of 8 for females and 9 for males; acceleration of the rate of statural growth and advancement of bone age one year older than the chronological age; lh peak \> 5 iu/l on gnrh test and a longitudinal uterine diameter \> 36 mm in females, with or without the appearance of endometrial rhyme; * age at onset of entral precocious puberty between 2 and 8 years (females) or between 2 and 9 years (males); * age at enrollment \< 18 years; * follow-up of at least 12 months; * obtaining informed consent from parents/legal guardian of peduatric patients. exclusion criteria: * isolated telarche and/or pubarche; * peripheral forms of precocious puberty; * patients diagnosed with primary organic central precocious puberty due to tumour- or non-tumour-causing hypothalamic lesions.

Keywords: central precocious puberty
viapaed study in children and adolescents with asthma

Conditions: Asthma

Summary: asthmatic children who remain symptomatic on inhaled corticosteroids (ics) require an adjustment of their asthma therapy. current guidelines suggest that the treatment options are either an increased dose of inhaled corticosteroid or the addition of other therapy such as a long-acting beta-agonist (laba). in the pediatric age range, major concerns with respect to high dose ics therapy are growth retardation and the suppression of the hypothalamic-pituitary-adrenocortical (hpa) axis. previous studies in adults have shown that a combination product that included a laba as well as the ics allowed to reduce the steroid dose and was still at least as effective in achieving asthma control as treatment with a higher dose of ics. these treatment options shall be compared in the present study. children who remain symptomatic while inhaling 100 µg fluticasone (fp) twice daily shall be randomized to receive the salmeterol/ fluticasone combination product, viani (seretide) 50/100 µg, or fluticasone 200 µg as a comparator drug, inhaled twice daily via the diskus for a period of eight weeks.


Eligibility criteria:
inclusion criteria: * children aged 4 to 16 years with an established history of perennial asthma. * subjects who are treated with an inhaled corticosteroid according to bdp (budesonide) 200-400 µg/day or equivalent during the last 4 weeks before run-in. * 15 minutes after inhaling 200µg of salbutamol, reversible increase in fev1 of at least 12% of the pre-dose value. * willingness to substitute previous controller medication on the twice daily inhalation of fluticasone 100µg bid via diskus®. * subjects/guardians who have given written informed consent to participate in the study. * subjects /guardians who are able to understand and complete a diary record card (drc). * subjects who are able to use a mini-wright peak flow meter. * sexually active female adolescents must use adequate contraception. * willingness to refrain from any other controller medication (including anti-leukotrienes) or from regular use of short-acting beta agonists or anticholinergics during the treatment period.

Keywords: moderate asthma fluticasone children salmeterol steroid-sparing asthma
randomized controlled trial of antibiotics in the management of children with community-acquired abscess

Conditions: Abscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess

Summary: the purpose of this study is to better understand why children develop methicillin-resistant staphylococcus aureus (mrsa) skin infections that require surgical drainage and whether antibiotics are helpful after the infection is drained in the operating room.

the emergence of community acquired methicillin-resistant staphylococcus aureus (mrsa) as a pervasive cause of skin and soft tissue infections has increased the number of children requiring incision and drainage (i\&d) procedures and heightened concerns about the optimal treatment strategy. data on patients with methicillin-sensitive staphylococcus aureus (mssa) abscesses, as well as emerging data on children with minor mrsa skin and soft tissue abscesses suggest that i\&d alone is sufficient therapy. however, given concerns about the pathogenicity of mrsa infections, many patients who require hospital admission and i\&d in the operating room receive postoperative antibiotics. the primary objective of this randomized controlled trial is to compare the effect of 5 days versus 1 day of postoperative antibiotics on the rate of treatment failure following i\&d of abscesses in children in the era of pervasive mrsa infection. secondary outcomes to be measured include incidence of additional skin and soft tissue infections in other body sites and incidence of these infections in family members and household contacts. prospective data will be collected from wound cultures, as well as from nasal, rectal and skin cultures sent at the time of initial i\&d to assess for mrsa carrier status. finally, survey data will be used to assess epidemiologic risk factors.

Eligibility criteria:
inclusion criteria: * children between 1 month and 17 years of age who undergo incision and drainage of a skin and soft tissue abscess by a member of the children's memorial hospital pediatric surgery faculty. exclusion criteria: * children who developed their infection while hospitalized or within 2 weeks of unrelated hospital discharge will be excluded. * children with surgical site infections will be excluded. * children with inherent or acquired immunodeficiency, including but not limited to transplant patients and patients on chemotherapy or systemic corticosteroids will be excluded. * patients admitted to the infectious disease service may be excluded at the discretion of the id attending. * patients who are found to have no discreet fluid collections at the time of attempted incision and drainage will be excluded. * patients allergic or intolerant to both bactrim and clindamycin will be excluded. * patients with cellulitis greater than 5 cm beyond the lateral margin of the abscess (as determined by intraoperative measurements) will be excluded.

Keywords: skin and soft tissue abscess methicillin-resistant staphylococcus aureus (mrsa) incision and drainage clindamycin trimethoprim-sulfamethoxazole skin infection
mindfulness and self-compassion focussed walking

Conditions: Breast Cancer; Fatigue

Summary: this research study is evaluating the effects of two training programs (1. walking, 2. mindfulness and self-compassion focussed walking) on tumor-specific symptoms of fatigue in women with breast cancer undergoing chemo- and/or radiotherapy.

this randomized research study is evaluating the effects of two training programs (1. walking, 2. mindfulness and self-compassion focussed walking (mscw)) on tumor-specific symptoms of fatigue in women with breast cancer undergoing chemo- and/or radiotherapy. the results of both groups are compared with each other and with those of a control group. the mscw program combines endurance based physical activity in the form of medically controlled walking, as well as standardized, evidence-based mindfulness exercise elements in a training program. the participants of both active groups (walking and mscw) practice for 12 weeks, once a week for 60 minutes under the guidance of a trainer in a group and 2 additional times (60 minutes each) independently at home. the purpose of this study is to prevent a sharp decline in quality of life due to fatigue symptoms by participating in the mscw training program. a total of 135 participants will be included in the study. all participants are followed for 1 year.

Eligibility criteria:
inclusion criteria: * patients diagnosed with breast cancer who have started antineoplastic therapy (chemotherapy / radiotherapy). * age ≥18 years * the patient must be able to perform the study intervention (physically and psychologically). * oral and written consent to participate in the study. exclusion criteria: * distant metastases * severe mental and / or additional organic illnesses * clinically relevant cardiac arrhythmias or angina pectoris * severe pulmonary disease * inadequate walking ability or gait disturbance (including neurological deficits, endoprosthesis supply that lead to gait insecurity) * regular meditation practice (several times a week) * planned start of meditation, relaxation, mbsr, yoga, qi gong courses over the next 24 weeks. * participation in other intervention studies on walking or meditation * insufficient knowledge of the german language

Keywords: tumor-specific fatigue syndrome mindfulness self-compassion
fitball program versus task-oriented motor program on improving postural control in developmental coordination disorder

Conditions: Developmental Coordination Disorder

Summary: children with developmental coordination disorder (dcd) often have poor postural control and motor skills that affect their activities of daily living and participation in school activities. the aim of this randomized controlled trial is to compare the effects of fitball training versus task-oriented motor training for children with dcd.


Eligibility criteria:
inclusion criteria: * diagnosis of dcd according to dsm-iv criteria * poor motor skills (movement assessment battery for children score \<15 percentile, or any two or more of subtests in bot ii \< 1.5 sd) * aged between 6-12 years old exclusion criteria: * have attended treatment for motor problems in the previous 6 months * any major co-morbid medical / neurological / sensory problems such as moderate to severe mental disability, profound visual or hearing impairment, severe sensory problems, or had any major behavioral problems.

Keywords: motor balance developmental physiotherapy
the effect of hatha yoga on mental health

Conditions: Depression; Anxiety; Mental Health Issue

Summary: the goal of this clinical trial is to determine the effects of a 10-week (2x a week; 45-minute per session) hatha yoga intervention in adults ages 18-25 (n = 45) on mental health outcomes. the main questions it aims to answer are: what is the effect of a hatha yoga intervention on depression and anxiety symptoms? what is the effect of a hatha yoga intervention on electroencephalogram (eeg) alpha and theta band power? what is the effect of hatha yoga intervention on heart rate variability? participants will be randomized to three groups: waitlist control (usual routine), hatha yoga (experimental group), and meditation (active comparative group). participants in the hatha yoga experimental group will attend 10 weeks of twice-weekly 45-minute yoga sessions. the active comparison meditation group will participate in 10 weeks of twice-weekly 45-minute meditation sessions. the control group will continue with their usual routine. researchers will compare changes in depression and anxiety symptoms, eeg alpha and theta band power, and heart rate variability between the three groups.

there are knowledge gaps that need to be addressed in understanding the effects of yoga, specifically long-term interventions, on physiological markers, electroencephalography (eeg) and heart rate variability (hrv) and elevated mental health symptoms in young adults. the present study will address the knowledge gaps by evaluating the effect of a 10-week (2x a week; 45-minute per session) hatha yoga intervention in adults ages 18-25 (n = 45). participants will be truly randomized to three groups: waitlist control (usual routine), hatha yoga (experimental group), and meditation (active comparative group). this design will allow the investigators to determine the effects of hatha yoga on relevant outcome measures. changes in depression symptoms (bdi), anxiety symptoms (bai), eeg alpha and theta band power, heart rate variability indices (rmssd, lf/hf) will be assessed. compared to the control group, investigators hypothesize that both the hatha yoga and meditation groups will exhibit an improvement in depression and anxiety symptoms, an increased alpha and theta band power at rest, and an increased rmssd and decreased lf/hf at rest. moreover, the investigators hypothesize that the hatha yoga group will improve body composition, flexibility, muscular endurance and strength, and cardiovascular recovery more than the meditation group.

Eligibility criteria:
inclusion criteria: * ages 18-35 * medically healthy to participate in physical activity as determined by the physical activity reading questionnaire (par-q) * concerned about or experiencing heightened anxiety, depression, and/or stress symptoms exclusion criteria: * those with diagnosed with an intellectual or developmental disability, currently diagnosed with a concussion, physically unhealthy to participate in physical activity * anyone currently taking beta-blockers
use of beetroot juice to protect against postoperative ileus (poi) following colorectal surgery: a pilot study.

Conditions: Postoperative Ileus

Summary: the beet it study investigates the possible protective effect of beetroot juice on poi following colorectal surgery in (partially) blinded single-center phase 2 randomized trial (pilot study).

postoperative ileus (poi) is a transient impairment of gastrointestinal motility following abdominal surgery, which leads to increased morbidity, prolonged hospitalization and increased healthcare cost. the pathogenesis of poi involves inflammation and oxidative stress, similar to ischemia/reperfusion injury that can be counteracted with beetroot juice. beetroot juice is a source of inorganic nitrate, which by conversion of nitrate to nitrite in the body, exerts its protective effect. we before demonstrated in a preclinical model that administration of exogenous nitrite was shown to protect against poi. the aim of this pilot study is to investigate the possible protective effect of beetroot juice ingestion on poi following colorectal surgery.

Eligibility criteria:
inclusion criteria: • all patients undergoing colonic or upper rectum laparoscopic surgery. exclusion criteria: * pregnancy or breast feeding * psychiatric pathology capable of affecting comprehension and judgment faculty * history of metastatic disease * history of prior abdominal bowel surgery * abdominal radiation treatment * chronic constipation (defined as two or fewer bowel movements per week) * gut motility influencing agents (e.g. tricyclic antidepressants, chronic use of laxatives) * frequent use of mouthwash, as this affects the enterosalivary circulation of nitrate * current use of broad-spectrum antibiotics, which will affect the oral flora and likely affect the nitrate reductase activity * more than one bowel anastomosis during this surgery
a trial of shr1701 combined with radiotherapy for metastatic non-small cell lung cancer failure after first-line treatment

Conditions: Non-Small-Cell Lung Cancer

Summary: this study is a single center, single arm, open study design. the main purpose of this study is to evaluate the tolerance and efficacy of shr1701 with synchronous radiotherapy in patients with metastatic non-small cell lung cancer who have failed after systematic treatment. large fraction radiotherapy is given to all lesions as much as possible, and low-dose radiotherapy is given to the lesions that cannot be tolerated or have no obvious benefit.


Eligibility criteria:
inclusion criteria: * subjects voluntarily participate in this study and sign informed consent. * nsclc in stage iv. * no clear driven genes (including but not limited to egfr、alk、ros1、cmet). * previously received more than 1 chemotherapy regimen and progressed/ recurred. * at least one lesion is suitable for hypofraction radiotherapy. * there is at least one measurable lesion. * 18 to 75 years old * ecog 0-1 * the function of vital organs meets the following requirements. anc ≥ 1.5×10\^9/l, plt≥100×10\^9/l, hb≥9g/dl, alb≥3g/dl, tsh ≤uln, bilirubin ≤ 1 times uln; alt and ast ≤1.5 times uln. akp ≤ 2.5 times uln. crea ≤1.5 times uln or ccr≥60ml/min# * the estimated survival period is more than 3 months. * female subjects of childbearing potential must have a negative serum pregnancy test within 72 hours before the first dose and must be willing to use very efficient barrier methods of contraception for the course of the study through 3 months after the last dose of study treatment exclusion criteria: the subjects had any history of autoimmune disease or active autoimmune disease. * subjects are using immunosuppressive agents, or systemic, or absorptive, local hormone therapy to achieve immunosuppression.it is still in use within 2 weeks of the entry. * subjects with severe allergic reactions to other monoclonal antibodies. * the subjects had a central nervous system metastases of clinical symptoms. * central squamous cell lung carcinoma. * imaging (ct or mri) shows that tumors invade large blood vessels or are indistinct with blood vessels. * imaging (ct or mri) showed significant pulmonary vacuity or necrotic tumors,borderline adenocarcinoma accompanied by a cavity can be considered after discussion with investigator. * failing to properly control the clinical symptoms or disease of the heart. * subjects had active infections. * subjects may receive other systemic antitumor therapy during the study period. * other clinical trials of drugs were used in the first four weeks of the first medication.

Keywords: shr1701,radiotherapy,nsclc
low-dose coronary computed tomographic angiography for early triage of acute chest pain

Conditions: Chest Pain

Summary: this study is to see whether the low-dose coronary computed tomographic angiography (ccta) protocol is as safe and efficacious as conventional-dose protocol in early triage of acute chest pain.

currently, ccta is a valuable tool for early triage of low to intermediate risk acute chest pain patients in emergency department. however, it has been criticized for causing unnecessary radiation exposure in the population where its majority has no coronary lesion. a low-dose ccta protocol comprised with 1) dedicated cardiac imaging protocol (rather than triple rule-out protocol), 2) prospective gating and 3) without additional imaging for calcium scoring will be used to implement the low-dose imaging. we hypothesized that the low-dose ccta protocol will be as safe and efficacious as conventional dose protocol while decreasing the amount of radiation exposure significantly.

Eligibility criteria:
inclusion criteria: - patients visiting emergency department for a) acute onset (\<12hr) chest pain or equivalent symptoms b) aged between 25-55, c) that requires to rule out acute coronary syndrome. exclusion criteria: 1. known coronary artery disease and/or any related intervention (stent, cabg) 2. elevated cardiac biomarkers (ck-mb, troponin i) 3. ischemic ecg changes 4. documented evidence of low lv systolic function (ejection fraction ≤ 45%) 5. timi risk \>4 6. unstable vital sign (e.g. hypoxemia, shock) 7. patients with contraindication to iodinated contrast and/or beta blockers including renal failure or reactive airway diseases such as copd or asthma 8. atrial fibrillation on initial ecgs 9. active renal disease, serum creatinine ≥1.5 mg/dl 10. negative coronary angiography or ccta within 6 months 11. modified wells criteria \>4 or d-dimer \> 0.5ug/ml 12. suspicious of aortic dissection or d-dimer \> 0.5ug/ml

Keywords: acute coronary syndrome cardiac computed tomographic angiography radiation dose reduction medical radiation exposure