Kornimate/medical-research-clean huggingface dataset:
reducing obesity using social ties program

Conditions: Obesity

Summary: this trial aims to test the feasibility and acceptability of addressing interpersonal barriers to weight-related behavior change. specifically, the study will test if, by including up to two friends, family members, or co-workers in a lifestyle intervention for weight loss, the person enrolled in the study loses more weight than someone whose friends, family members, or co-workers were not invited to participate.

the investigators will evaluate whether the robust intervention not only addresses individual-level behaviors (i.e., healthy eating, increased physical activity) but also: 1. reduces social undermining as well as changes perceived health norms by activating communal coping - a behavioral process that involves thinking, communicating, and acting as if a health risk (i.e., type 2 diabetes) is shared; and 2. dampens the harmful effects of increased interpersonal conflict on weight by teaching participants how to induce a positive affect and self-affirming mindset participants in the control arm will receive the same number of lifestyle sessions as those randomized to the social network intervention. participants will: 1. be randomly assigned to either the study group, which is asked to invite up to two friends or family members to join them at three coaching sessions, or the group that does not invite anyone. 2. receive 15 coaching sessions over 24 weeks. 3. complete an online questionnaire about eating and physical activity habits, confidence in developing healthier habits, mood, and health habits of twelve of their closest friends and family members. 4. complete a 3-day weekly food log and wear a provided fitbit for at least 9 hours daily. 5. the invited friends and family members will also be asked to complete a brief questionnaire about their eating and physical activity habits when they start and end the study.

Eligibility criteria:
inclusion criteria: * index participant: 1. black race or hispanic ethnicity 2. male or female 18 years of age or older 3. calculated bmi \> 30kg/m2 from objectively measured height and weight by study staff 4. access \& willingness to use program food intake app via home computer or a smartphone 5. ability to identify at least one adult social network member who will participate in the study * social network member: 1. male or female 18 years of age or older 2. access to the internet or a smartphone exclusion criteria: * index participant: 1. active enrollment in a weight-loss program, use of weight-loss medications, or planning weight-loss surgery 2. advanced medical illness, dementia, hospitalization, injury, or pregnancy that inhibits regular physical activity 3. contraindications to exercise based on the physical activity readiness questionnaire or lack of clearance from a health care provider 4. unresolved food insecurity 5. speaks a language other than english or spanish * social network member: 1. speaks a language other than english or spanish

Keywords: weight loss undermining communication
interest of a teteleconsultation of a psychological support nurse on psychological distress in patients with a primary malignancy of the central nervous system

Conditions: Central Nervous System Cancer; Psychological Distress

Summary: the goal of this clinal trial is to compare the effectiveness of nurse-led teleconsultation with usual care (intervention group) on psychological distress in patients with primary malignant tumors of the central nervous system between diagnosis and first anti-cancer treatment, versus usual care alone (control group). participants will be randomized into two groups : * group a) intervention: usual care + nurse teleconsultation for psychological support * group b) control: usual care alone enrolment = day0 (d0) participants will : * groups a and b: d0: complete 4 questionnaires (quality of life, screening for distress, screening for anxiety and depression, social support questionnaire) * group a : d0+2/4 das : nursing teleconsultation for psychological support * groups a and b: d0+10days : telephone call to complete the same 4 questionnaires as at inclusion * group a : d0+15days: semi-directive interview, at home, for voluntary patients.

the expected benefits are as follows: for the patient : * reduction in pre-treatment psychological distress * reduced pre-treatment anxiety and depression * better understanding of disease and treatments * better adherence to the care proposed in the treatment pathway * reduced stress during first hospital treatment for healthcare professionals : * early detection of psychological distress * early detection of unmet needs and appropriate individualized responses * establishment of a climate of trust between patient and caregiver * improved professional practices for the healthcare system : * lower healthcare costs (fewer anxiolytic treatments, etc.) * therapy to be integrated into the treatment pathway of patients with central nervous system cancer * reduced socio-territorial inequalities in healthcare provision

Eligibility criteria:
inclusion criteria: * aged 18 and over * being treated for a primary malignant tumor of the central nervous system (positive biopsy) * with a mini-mental state score greater than 24 * not receiving first-line treatment (chemotherapy, targeted radiotherapy, surgery) * with a distress score above 3 on the psychological distress thermometer * have access to computer equipment equipped with a microphone and webcam (smartphone, computer) * able to read, write and speak french * have given free and informed consent * being affiliated to a social security scheme exclusion criteria: * with a history of psychiatric illness * with recurrent cancer of the cerebral nervous system * having begun first-line treatment (drug therapy, curative surgery, radiotherapy or palliative care) * under guardianship, curatorship or deprived of liberty
applicability and safety of vibration therapy in intensive care unit (icu) patients

Conditions: Respiratory Failure; Sepsis; Brain Injury

Summary: vibration therapy is used for different indications in rehabilitation and sports medicine. so far, vibration therapy has not been investigated within the icu setting. the investigators created this setting to show safety and applicability of vibration therapy in icu patients. 30 patients will be stimulated by vibration therapy on two separate days during their icu stay. three collectives of equal size will be observed: one with patients on mechanical ventilation without signs of infection or suspected intracranial pressure problems, a second one with patients on mechanical ventilation in addition to signs of systemic inflammation but absence of suspected intracranial pressure problems, and a third one with patients on mechanical ventilation, signs of systemic inflammation in addition to presence of controlled intracranial pressure problems. typical parameters of hemodynamic status, intracranial pressure and energy metabolism will be recorded for a defined period of time before, during and after vibration therapy itself. vibration therapy will be combined with protocol based physiotherapy. our aim is to show the effects of vibration therapy in icu patients and its safe applicability. addition 06th of may 2011: additionally we will perform euglycaemic hyperinsulinemic clamp and intervention on one day of icu stay in 20 patients. under clamp conditions we will perform a vibration therapy (promedvi vibrosphere™) on patients' legs. on top we will perform electrical muscle stimulation (schwa-medico, muskelaktiv™) on one ventral upper leg, randomized chosen. measuring the local skeletal muscle metabolism will be done by microdialysis in vastus lateralis on both sides - comparing vibration therapy and vibration therapy combined with electrical muscle stimulation.


Eligibility criteria:
inclusion criteria: * immobilized icu patients: * with mechanical ventilation without signs of infection * with mechanical ventilation and sirs or sepsis * with mechanical ventilation, with controlled elevated intracranial pressure and with or without sirs or sepsis * signed declaration of consent by the patient or its legal proxy exclusion criteria: * age \< 18 years old * already known neuromuscular disease * missing declaration of consent by the patient or its legal proxy * implanted heart pacemaker or defibrillator * pregnancy * acute thrombosis * not yet healed fracture ad the part of the body which will be trained * implants ad the part of the body which will be trained * a nearly done ophthalmic surgery * acute disc prolapse * infaust prognosis, that means death is expected into the next couple of hours, although maximum therapy is done

Keywords: vibration icu blood pressure intracranial pressure infection indirect calorimetry
cartilage versus temporalis fascia graft in tympanoplasty for recurrent tympanic membrane perforation '' comparative study ''

Conditions: Tympanic Membrane Perforation

Summary: use of cartilage versus temporalis fascia as a graft in tympanoplasty for recurrent tympanic membrane perforation

the main aim of successful tympanoplasty is to create a well aerated closed cavity after total removal of the disease. numerous types of grafting materials have been used for closure of the tympanic membrane including fascia, periosteum, perichondrium, cartilage, vein, skin, and fat tissue . autografts are thought to be the most compatible grafting materials with the best surgical results in tympanoplasty temporal muscle fascia is composed of irregularly arranged elastic fibers and fibrous connective tissue. for this reason postoperative dimensions of temporal muscle fascia are unpredictable. cartilage has a constant shape, firmer than fascia and also lack fibrous tissue, so that postoperative dimensions remains the same and beside this, it is also nourished by diffusion and show great adaptation with tm . these advantages make the cartilage graft more preferable by otologists recently. the use of cartilage graft in many different ways such as perichondrium cartilage island technique, palisade technique or cartilage reinforcement technique

Eligibility criteria:
inclusion criteria: * patients with safe chronic suppurative otitis media patient with recurrent perforation patirnt with coductive hearing loss exclusion criteria: * sensorineural hearing loss active infection compromised immune system
safety and efficacy of nebivolol in the treatment of hypertension in african americans

Conditions: Hypertension

Summary: the purpose of this study is to evaluate the effects of nebivolol on blood pressure and heart rate in african american patients with hypertension.

despite the established benefits of beta-blockers, their use is limited by their side effect profile and by a perception of reduced efficacy in certain populations such as african americans (amudha, 2003). this is a double-blind, randomized, placebo and active-controlled, multi-center, parallel group, forced titration study. patients will be stratified across all treatment arms by age, gender, and diabetes status (history of diabetes mellitus vs no history of diabetes mellitus). the study consists of 3 periods: screening run-in, double-blind, randomized, forced titration and double-blind, washout period (only for patients who complete the double-blind, forced titration period and who are not participating in the long-term follow-up study). after a 14-28 day, single-blind, placebo controlled, run-in period, which includes washout (if applicable), eligible patients will be randomized to one of 3 treatment regimens for approximately 12 weeks. this study will test the safety and efficacy of nebivolol in the treatment of african american patients with hypertension.

Eligibility criteria:
inclusion criteria: * african americans with stage 1-2 hypertension exclusion criteria: * recent myocardial infarction or stroke * contraindications to beta-blocker therapy or stopping prior antihypertensive therapy

Keywords: nebivolol
a study to determine if an investigational pain medicine provides relief of chronic pain after a shingles outbreak

Conditions: Postherpetic Neuralgia

Summary: the purpose of this study is to determine whether t-62 is effective in providing relief of pain that can occur after an individual experiences a shingles outbreak, which is an infection in adults caused by the same virus that causes chicken pox.


Eligibility criteria:
inclusion criteria: * has a clinical diagnosis of postherpetic neuralgia (phn) * experiencing pain for at least 3 months after the healing of shingles rash * has at least a weekly average pain intensity of equal to or greater than 4 out of 10 * females must not be pregnant or breastfeeding and practicing an acceptable method of birth control, or be surgically sterile or post-menopausal * will not consume grapefruit or grapefruit juice during the study exclusion criteria: * has a current acute or unstable chronic disease other than postherpetic neuralgia (phn) * has clinically important medical disorder * uses certain types of medications for heart conditions * unwilling/unable to discontinue use of medications for treatment of neuropathic pain * has a history of hypersensitivity to any medication or soy product * has liver or kidney disease * has asthma that required treatment within the last year * has hiv or hepatitis (other than hepatitis a) * has a history of alcohol abuse within the past 2 years * has a history of (within last 2 years) or currently abuses prescription or illegal drugs

Keywords: pain postherpetic neuralgia neuralgia, postherpetic shingles herpes zoster neuropathic pain
real-world registry study of red light treatment on myopia control: a focus on non-responders to conventional treatments

Conditions: Myopia; Repeated Low-level Red Light

Summary: this real-world observational registry study aims to assess the effectiveness of repeated low-level red light (rlrl) therapy in controlling myopia progression among children aged 8 to 16 who have not responded to conventional treatments like orthokeratology and atropine eyedrops. the primary focus is to determine if rlrl therapy can limit axial length (al) elongation to less than 0.1mm per year and spherical equivalent refraction (ser) progression to less than 0.25 diopter per year, while also evaluating safety and visual outcomes.


Eligibility criteria:
inclusion criteria: 1. age: 8 to 16 years at the time of data collection, aligning with the approved usage guidelines of the rlrl device. 2. diagnosed with myopia and have been under conventional myopia treatments (include orthokeratology, defocus incorporated multiple segments spectacles or equivalent, and 0.01% atropine or 0.05% atropine eyedrops) for at least six months. eligible patient data must demonstrate insufficient control of myopia progression, defined as an axial elongation of 0.3 mm or more, or ser progression of 0.5 diopter or greater per year. 3. best corrected visual acuity (bcva): 20/20 or greater. 4. data from patients who have utilized or are utilizing red light therapy as part of their myopia management strategy. exclusion criteria: 1. ophthalmic diseases other than refractive errors, including but not limited to strabismus and binocular vision abnormalities in either eye. 2. presence of systemic diseases (e.g., endocrine, cardiac diseases) and developmental abnormalities. 3. concurrent use of atropine eye drops and rlrl therapy.
effect of kangaroo mother care on oxidative stress and bonding

Conditions: Kangaroo Mother Care; Oxidative Stress

Summary: the goal of this clinical trial is to learn if kangaroo mother care can have effect on oxidative stress in premature neonates. it will also learn about the bonding between mother and her premature infant. the main questions it aims to answer are: * does kangaroo mother care lower the biomarker of oxidative stress in premature neonates? * is kangaroo mother care associated with mother-infant bonding? researchers will compare kangaroo mother care to conventional incubator care to see if kangaroo mother care works to have effect on oxidative stress. participants will be: * given kangaroo mother care on third day of life or standard incubator care for one hour * urine sample for oxidative stress biomarker will be collected via noninvasive method before and after kangaroo mother care or conventional incubator care from premature neonates. * mother-infant bonding scale will be filled by mothers of enrolled premature infants before and after kangaroo mother care and conventional incubator care

researcher will follow existing guidelines for shifting of infant from incubator to the mother's chest. the researcher will assist the mothers to have the baby from the incubator and to sit in the special kmc chair and bed. urine will be collected from premature infants before and after kmc/incubator care on third day of life by applying urine collection bag. this method is highly successful in collecting urine non-invasively. collected urine is then placed in ice box till transportation to lab at university of health sciences(uhs). and stored at -80 °c. after completion of data collection enzyme-linked immunosorbent assay elisa kit of oxidative stress biomarker (allantoin) will be used for checking level of allantoin in stored samples within a week. mothers of both the kmc and control groups will be given the mother-infant bonding scale (mibs) self-rating instrument on 3rd day postpartum before and after kmc and incubator care for bonding assessment.

Eligibility criteria:
inclusion criteria: * for pre-term neonates: 1. 24-36 weeks' gestation premature infants 2. medically stable as determined by a score of neonatal acute physiology \& perinatal extension (snappe-ii); pre-term neonates with score of less than 9. 3. both gender 4. weight 1.5kg to 2.499 kg for mothers of pre-term neonates: 1. medically stable mothers. exclusion criteria: the criteria for exclusion will be as follows: for pre-term neonates: those will be excluded who are with below given conditions: 1. require any kind of surgery. 2. intraventricular hemorrhage (ivh) \> or equal to grade 3. 3. on medication such as morphine, fentanyl, midazolam, muscle relaxants, phenobarbital. 4. severe cyanotic heart disease or severe rds. 5. abdominal wall or intestinal anomaly or injury. 6. chromosomal disorder 7. facial anomaly. for mothers of pre-term neonates: 1. mothers having complications of delivery like post partem hemorrhage. 2. any acute illness 3. complicated cesarean section

Keywords: bonding kangaroo mother care oxidative stress prematurety allantoin
a trial comparing two approaches to weight loss

Conditions: Overweight and Obesity

Summary: this study compared the recently developed transforming your life (tyl) weight loss program to the diabetes prevention program (dpp), considered the "gold standard" in behavioral weight loss treatment.

weight loss programs evidence considerable variability in treatment outcomes and weight regain is common, signaling the need for the refinement of effective treatments. this study compared the recently developed transforming your life (tyl) program to the diabetes prevention program (dpp), considered the "gold standard" in behavioral weight loss treatment.

Eligibility criteria:
inclusion criteria 1. overweight/obese (body mass index\>27 kg/m2) 2. free from serious medical conditions that would complicate participation in the intervention via adherence or mobility (e.g., serious heart disease or musculoskeletal problems that would interfere with moderate exercise) 3. had not undergone bariatric surgery 4. able to provide medical clearance from their physician. exclusion criteria 1. evidence of medical conditions that would complicate participation in the intervention via adherence or mobility (e.g., serious heart disease or musculoskeletal problems that would interfere with moderate exercise) 2. had undergone bariatric surgery,

Keywords: weight loss treatment obesity
effects of 3% sodium chloride on post-operative dysphagia following anterior cervical spine surgery

Conditions: Dysphagia

Summary: post-operative dysphagia is a significant issue following anterior cervical spine surgery. the investigators are studying the effects of perioperative 3% sodium chloride, given over a period of 24 hours, on post-operative dysphagia. the goal is to reduce the incidence and severity of post-operative dysphagia.

based on a priori analysis the investigators will need 100 subjects in a placebo arm (normal saline) and 100 subjects in a treatment arm (3% sodium chloride), for a total of 200 patients. this study will be conducted on healthy subjects with normal renal function undergoing anterior cervical discectomy and fusion for degenerative indications only. subjects will be randomized to the treatment or placebo arm (which will be double blinded). subjects in the treatment arm will begin to receive intravenous 3% sodium chloride before the incision is made. the solution will be given at a rate of 10 cc/hour over a period of 24 hours. baseline, post-operative, and delayed post-operative dysphagia surveys will be administered either in person or by telephone. the investigators hope to decrease the incidence and severity of post-operative dysphagia.

Eligibility criteria:
inclusion criteria: * adult patients undergoing anterior cervical discectomy and fusion for degenerative indications exclusion criteria: * history of cervical trauma * baseline dysphagia * age less than 18 years old * history of previous anterior neck surgery * creatinine clearance less than 30 * creatinine greater than 1.0 * baseline sodium greater than 145 * patients with known electrolyte abnormalities * congestive heart failure
an intervention to improve nutrition and physical activity in preschoolers in cuenca, ecuador

Conditions: Obesity; Overweight; Underweight

Summary: the aim of this study is to design and evaluate an educational and behavioral intervention focused on improving nutrition and physical activity habits among preschoolers in cuenca, ecuador, with the overarching goal of preventing overweight/obesity and promoting the formation of healthy nutrition/physical activity habits.

in ecuador and in the city of cuenca, the prevalence of obesity is high (approximately 22% of the population). simultaneously, there is high prevalence of chronic malnutrition (e.g., stunting). in a previous study in school-aged children in cuenca, the prevalence of overweight or obese was 30%. the objective of this study is to design an intervention to improve nutrition and physical activity habits and behaviors in preschoolers. the study will begin with a baseline survey that will be used to develop the educational and behavioral intervention. the intervention will consist of didactic material for teachers, educational material for parents, and activities for the children. the investigators will carry out the intervention over the course of the school year. the intervention will be primarily delivered in the preschool setting, but will also include workshops for parents. the investigators hope that this study will help promote the health of children in cuenca and can be a pilot study to test similar interventions in larger populations in ecuador.

Eligibility criteria:
inclusion criteria: any child attending a preschool of the municipality exclusion criteria: any child whose parents decline inclusion in the study

Keywords: nutrition physical activity overweight obesity malnutrition