Kornimate/medical-research-clean huggingface dataset:
impact of a tolerability switch to dorzolamide/timolol preservative-free fixed combination on ocular surface symptoms

Conditions: Open Angle Glaucoma

Summary: this study aims at validating in real-life clinical practice and using the self-reported glaucoma symptom scale (gss) questionnaire, the impact of a switch to preservative-free dorzolamide/timolol fixed combination (dtfc) in patients using preserved topical therapy for glaucoma.

the study is an 8-week multi-center, prospective, observational and non-interventional, open-label study aiming at assessing a change in visual-related quality of life of glaucoma patients that switch therapy to preservative-free dtfc. as a non-interventional study, the decision for the to switch was at the discretion of the physician. patients scheduled to switch therapy to preservative free dtfc will be asked to fill in the 10 item, linkert-type gss questionnaire at baseline, at week 4 and at week 8 of therapy switch. the study data will be collected at a baseline and at 2 follow-up visits occurring 4 weeks +/- 1 week and 8 weeks +/- 1 week. if no visit was scheduled, the patient was asked to send the completed documents to the physician.

Eligibility criteria:
inclusion criteria: * adults patients aged over 18 years old at inclusion visit * diagnosed as having oag in one or both eyes * who have used the previous preserved eye drops treatment for at least 4 weeks in one eye or both eyes * experiencing pre-established ocular surface disease symptoms, as defined in the 2007 report of the international dry eye workshop * being scheduled by their ophthalmologist for a switch to preservative-free dtfc eye drops (as monotherapy or replacement of one preserved product of a combined therapy) at inclusion visit due to tolerability issues * accepting to participate in the study and who has provided a written informed consent exclusion criteria: * patients who had filtering or other ocular surgery within the 6 months preceding the inclusion visit * who have already been treated with preservative-free dtfc * whose visual acuity is importantly impaired by a severe ocular disease other than oag, as assessed by the physician * currently involved in a clinical trial or study cohort or pharmaco-epidemiology study or interventional study * with serious mental or physical disability which could interfere with a patient-reported assessment * pregnant women.

Keywords: glaucoma
the use of shear wave elastography, transvaginal ultrasound and pelvic mri in the diagnosis of adenomyosis

Conditions: Adenomyosis; Elastography; Transvaginal Ultrasound; Fibroid Uterus

Summary: in this prospective cohort study, the patients who were diagnosed with either uterine fibroid (control group) or adenomyosis (study group), were examined with transvaginal ultrasound and shear wave elastography. definitive diagnosis was established by pelvic mri. shear wave elastography data of both groups were compared. features of adenomyosis on transvaginal ultrasound were also recorded for study group.

in this prospective cohort study, the patients who applied to the gynecology and infertility outpatient clinic in istanbul university faculty of medicine between october 2018 and october 2021 due to abnormal uterine bleeding, pelvic pain, infertility were evaluated. the patients who were diagnosed with adenomyosis and uterine myoma according to clinical evaluation were included and grouped. clinical diagnosis were confirmed with contrast enhanced pelvic magnetic resonance imaging. no histopathological confirmation were included in this study. 34 patients were included in adenomyosis group and 31 patients were included in myoma group. all patients were evaluated with shear wave elastography; 3 regions of interest were selected for each elastographic evaluation. average shear values were determined automatically; then, minimum and maximum mean shear values were recorded accordingly. elastography values of both groups were compared in order to detect any statistically significant difference between 2 groups. in addition to elastography evaluation, the compatibility of transvaginal ultrasound and magnetic resonance were evaluated.

Eligibility criteria:
inclusion criteria: * patients who applied to outpatient clinic due to abnormal uterine bleeding, pelvic pain, infertility. exclusion criteria: * patients who are currently pregnant or has current malignancy, use combined oral contraceptives, gonadotropin releasing hormone agonist, intrauterine device or currently taking hormonal replacement therapy.
addressing uncontrolled diabetes in primary care: a lifestyle redesign approach

Conditions: Diabetes Mellitus

Summary: this study is examining the feasibility of implementing an occupational therapy intervention addressing diabetes management in a primary care clinic within the los angeles county department of health services (lac-dhs), as well as the impact of this intervention approach on clinical outcomes, efficiency and patient-centeredness of care. this implementation science study is evaluating two emerging trends in healthcare delivery: (1) the integration of nontraditional providers into primary care medical home (pcmh) settings to facilitate the delivery of high-quality, comprehensive primary care while reducing the burden on physicians; and (2) the potential value of using occupational therapists to address chronic disease management in this setting


Eligibility criteria:
inclusion criteria: * current patient at los angeles county-usc medical center adult west primary care clinic * diagnosed diabetes (type 1 or type 2) documented in emr * most recent hba1c level \>9.0% or has not had an hba1c measurement within past 12 months * per provider judgment, would be willing to make lifestyle changes related to diabetes self-care exclusion criteria: * active, untreated substance use or behavioral health disorder which interferes with participation in major life activities
coaching for hcv and hiv

Conditions: Hepatitis C; HIV Infections; Opioid-use Disorder

Summary: the objective of this study is to determine the feasibility and acceptability of a peer recovery coach (prc) intervention to improve linkage to hepatitis c (hcv) and/or human immunodeficiency virus (hiv) care, treatment initiation, and evaluation for hiv pre-exposure prophylaxis (prep) (when applicable) among individuals with a history of opioid use disorder accessing a substance use low-barrier-to-access (lba) walk-in clinic. in-depth interviews will be administered to participants at baseline, three- and six-months for study participants (40 total participants). the investigator will also follow-up with the per recovery coach and administer surveys to assess the feasibility of a peer recovery coaching intervention in improving hcv/hiv related linkage to care and management. patient medical records and peer recovery coach monthly reports will be accessed and reviewed to determine fidelity to research protocols.

\*note\* due to the covid-19 pandemic, surveys were conducted via telephone and not all participants could be contacted. therefore, the number of results from participants at three months and six months vary. the data gathered are from participants that were reachable and completed the surveys.

Eligibility criteria:
inclusion criteria: * individuals with opioid use disorder, non-reactive hiv antibody test and reactive hcv antibody testing at the bmc lba walk-in clinic * able to speak english * individuals providing contact information of two family members or friends * individuals signing a medical records release form exclusion criteria: * individuals already linked to substance use care * individuals co-infected with hiv and hcv and engaged in care

Keywords: peer recovery coach (prc) pre-exposure prophylaxis (prep) hiv care hcv care low-barrier-to-access (lba)
restoring upright mobility after spinal cord injury

Conditions: Spinal Cord Injuries; Spinal Cord Diseases

Summary: up to 15 able-bodied individuals will participate in one testing session to evaluate the effectiveness of the a-fes system. up to 20 individuals with sci will participate in 12 sessions of a-fes therapy. at each session, participants will stand on a force plate (accu sway, amti, usa) with the a-fes system (compex motion ii, compex motion, switzerland) donned. the centre of pressure (cop) will be calculated in real time using the force plate data. the calculated cop will be presented to participants on a monitor and they will be instructed to shift their cop in the indicated directions as represented by a cursor (i.e. training with visual feedback). the intensity of electrical stimulation provided by the a-fes system will be regulated by the measured cop in a closed-loop manner. in this study we propose to develop and evaluate the clinically-feasible a-fes system for the training of standing balance.


Eligibility criteria:
inclusion criteria: 1. a traumatic or non-traumatic, non-progressive (ais) c or d sci; 2. ≥18 years old; 3. able to stand independently for 60s; 4. moderate level of trunk control as evidenced by the ability to reach forward \>2 inches in standing (i.e. score of 2 on the bbs reaching forward task50,51); and 5. free of any other condition besides sci that significantly affects walking or balance (e.g., no vestibular disorder, significant vision loss, stroke). exclusion criteria: 1. severe spasticity in the legs; 2. contractures in the lower extremities that prevent achieving a neutral hip and ankle position, or extended knee; 3. a prior lower extremity fragility fracture; 4. an injection of botulinum toxin to leg muscles in the past six months; 5. peripheral nerve damage in the legs (i.e. leg muscles unresponsive to electrical stimulation); 6. a pressure sore (\>grade 2) on the pelvis or trunk where the safety harness is applied; o 7. contraindications for fes52 (i.e. implanted electronic device, active cancer or radiation in past 6 months, epilepsy, skin rash/wound at a potential electrode site). participants will be withdrawn from the study if fes irritates their skin.

Keywords: balance functional electrical stimulation
stress management and resiliency training (smart) for family medicine residents at eglin afb

Conditions: Stress; Quality of Life

Summary: this research seeks to identify if the practice of the smart program mindfulness decreases stress and increase resilience in family medicine residents.

this research seeks to identify if the practice of the smart program mindfulness decreases stress and increase resilience in family medicine residents.

Eligibility criteria:
\*\*patients must be able to get care at eglin air force base (a military installation) in order to participate in this study\*\* inclusion criteria: * male and female active duty military family medicine residents * age 18 or older * amenable to participation in training and filling out questionnaires exclusion criteria: * unwilling to participate
reducing drug craving memories

Conditions: Cocaine Addiction

Summary: the primary objective is to investigate the potential ability of inderal (propranolol hydrochloride) to diminish the reconsolidation of motivationally potent drug-related cues in cocaine dependent participants. if effective in this laboratory model, inderal may have clinical efficacy.


Eligibility criteria:
inclusion criteria: * 60 psychotropic medication-free men or women (15 subjects x 4 groups) who have met dsm-iv-tr diagnostic criteria for cocaine dependence for the past 6 months (age 18 - 50 years old); * minimum of three days cocaine abstinent on study days; * primary use of cocaine is intra-nasal or smoked crack exclusion criteria: * medical conditions that might be aggravated by participation in the study: * cardiovascular disorders that might be aggravated by participation in the study: hypotension (sbp: \ 160 mmhg; dbp: \> 100 mmhg), myocardial infarction, history of chest pain and admission to ed for chest pain; * respiratory disorders: bronchial asthma and chronic obstructive pulmonary disease; * diabetic patients treated with insulin or oral hypoglycemic agents. propranolol may mask the first signs of a developing hypoglycemia. * seropositive pregnancy test * comorbidity with current axis i psychiatric disorders other than anxiety, affective and substance use disorders * severe liver disfunction * current or recent (\< 5 half lives) use of medications that may interact with inderal (see above) * positive urine tox screen for barbiturates. positive breath alcohol screen. {note: all urine tox screen results will be destroyed immediately after collection. the information will not be stored}

Keywords: cocaine addiction treatment craving
digital vs. speculum exams for pprom

Conditions: PPROM

Summary: after preterm prelabor rupture of membranes (pprom)\[breaking of the amniotic sac prior to 37 weeks gestation in pregnancy\], patients are recommended for inpatient admission and close monitoring for complications including preterm labor, intraamniotic infection (infection of the sac around the baby), and placental abruption (separation of the placenta from wall of the uterus). when evaluation of cervical dilation is clinically indicated, obstetricians traditionally perform sterile speculum exams due to concern for decrease in pregnancy latency (length of time between breaking the water and delivery) with sterile digital exams in retrospective studies. these studies are concerning, however, by the indications for the exams and are at risk for confounding by indication. this is a randomized, non-inferiority trial to examine if sterile digital versus speculum exams effect latency of pregnancy in patients with pprom.


Eligibility criteria:
inclusion criteria: * 22 weeks 0 days gestation to 33 weeks 5 days gestation * clinical or laboratory confirmation of pprom * at least 8 hours after rupture event * english speaking notably, for patients \<25 weeks, approach for enrollment will be deferred until after the patient has discussed their desires for fetal resuscitation with the care team and are at a gestational age where they would desire this resuscitation. exclusion criteria: * contraindications to digital examination * covid-19 positive on admission

Keywords: pprom speculum exam preterm birth preterm prelabor rupture of membranes
a study to evaluate procrit (epoetin alfa) for maintenance phase treatment of patients with anemia due to chronic kidney disease (prompt)

Conditions: Anemia; Chronic Renal Insufficiency

Summary: the purpose of this study is to evaluate the effectiveness and safety of less frequent dosing of procrit (epoetin alfa) in patients with anemia due to chronic kidney disease (ckd) as assessed by hemoglobin maintenance, adverse events and health-related quality of life.

epoetin alfa has been widely utilized as treatment for anemia associated with chronic kidney disease (ckd). epoetin alfa has been shown to increase hemoglobin (hb) levels by an average of 1.5 g/dl to 2 g/dl in these patients over 12 weeks (data on file ortho biotech products, l.p.). this improvement in hb levels is maintained while the patient is receiving epoetin alfa and is associated with significant improvements in survival, exercise tolerance, and quality of life. literature has suggested that epoetin alfa can be given less frequently and still maintain an optimal hemoglobin while also allowing patient's greater convenience. this study will further confirm that less frequent dosing of epoetin alfa is safe and effective. this is an open-label, randomized multicenter study in patients with ckd. ckd patients who are currently receiving procrit therapy for at least 2 months or more and with a stable hb (\>= 11g/dl) will be randomized to one of four treatment groups. a stable hemoglobin will be defined as a value that is ± 10% for 3 consecutive laboratory values. this study is designed to demonstrate that there is no meaningful difference in hemoglobin level with more extended dosing regimens as compared to once weekly. a clinically meaningful difference is defined as a difference that is less than 10%. patients will be randomized to one of 4 treatment groups: all will receive subcutaneous (under the skin) epoetin alfa for a period of 16 weeks. group 1: 10,000 units every week group 2: 20,000 units every two weeks group 3: 30,000 units every three weeks group 4: 40,000 units every four weeks

Eligibility criteria:
inclusion criteria: * ckd patients (defined as serum creatinine 1.5 to 6.0 mg/dl for women and 2.0 to 6.0 g/mg/dl for men) * stable hb (\>= 11.0g/dl) and currently receiving procrit therapy for 2 months or more. a stable hemoglobin will be defined as a value that is ± 10% for 3 consecutive laboratory values. exclusion criteria: * lactating or pregnant women * uncontrolled hypertension * known hypersensitivity to mammalian cell-derived products and human albumin * receiving dialysis or scheduled to receive dialysis during the course of the study * gastrointestinal bleeding * severe congestive heart failure (new york heart association class iv) * concurrent chemotherapy for cancer * history of/or active blood disorders, liver diseases or seizures * hiv positive * received a kidney transplant

Keywords: anemia low blood count chronic kidney failure chronic kidney disease epoetin alfa recombinant human erythropoietin
safety and immunogenicity of 2-dose inactivated covid-19 vaccine in kidney transplant recipients

Conditions: Kidney Transplantation; SARS-CoV-2 Acute Respiratory Disease; Vaccine

Summary: the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) has a major impact on transplant recipients, with mortality rates up to 20%. however, immunocompromised individuals have been excluded from studies of sars-cov-2 vaccines. in such patients, the immune response to vaccination may be blunted. to better understand the immunogenicity of sars-cov-2 vaccines in transplant recipients, we quantified the humoral response to sars-cov-2 vaccine in kidney transplant recipients.


Eligibility criteria:
inclusion criteria: receiving kidney transplantation in west china hospital, sichuan university exclusion criteria: 1) history of rejection or infection over the previous 3 months; 2) receiving kidney transplantation \>3 months; 3) combined with hbv/hvc/hiv infection in the donor or recipient; 4) malignancy history in the donor and recipient; 5) organ transplant history in the recipient.
validation of the french version of the inflammatory bowel disease questionnaire (ibdq) for ulcerative colitis and crohn's disease

Conditions: Ulcerative Colitis; Crohn's Disease

Summary: the purpose of the study is to develop a validated french version of the ibdq in a cohort of patients suffering from inflammatory bowel diseases, namely crohn's disease and ulcerative colitis.

importance of measuring subjective aspects of the patient's health, often referred to as quality of life (qol), become increasingly recognized and integrated into healthcare. for this purpose, the inflammatory bowel disease questionnaire (ibdq) is a widely used questionnaire for qol assessment specific for patients who suffer from inflammatory bowel diseases. however, the ibdq was originally developed in a cohort of canadian patients in english language. since qol is impacted by underlying cultural trends, any translation of the ibdq should be reassessed in relation to its validity, reliability, and sensitivity to detect change in the new language and cultural context. while the linguistic french translation of the original ibdq has been validated, the french ibdq has never been tested adequately on a french cohort of patient that we aim to perform.

Eligibility criteria:
inclusion criteria: * men and women ≥ 18 years of age, * patient with definite diagnosis of uc or cd for at least 6 months exclusion criteria: * adults legally protected (under judicial protection, guardianship, or supervision), persons deprived of their liberty * inability to comprehend or complete the self-administered questionnaire * psychiatric diagnosis that prevents participation (many pts will have anxiety or depression and should not be excluded) * stoma * malignancy

Keywords: inflammatory bowel diseases inflammatory bowel disease questionnaire (ibdq)
the efficacy of computerized alcohol screening and intervention (casi) in at-risk emergency department and trauma patients

Conditions: Alcohol Consumption

Summary: the purpose of this research is to examine the effectiveness of computerized alcohol screening and brief intervention in the uc irvine medical center emergency department (ed) and trauma patients. brief interventions have a high potential impact in ed and trauma populations. computerized alcohol screening and brief intervention (casi) is a fast and easy to use tool for patients and healthcare providers. casi mitigates barriers to proper screening and intervention, including time, availability of trained personnel, patient comfort, and language barriers. casi provides the alcohol use disorders identification test (audit) followed by a brief intervention and customized alcohol intake recomendations for the patient. the intervention of this study will be the addition of a brief casi questionnaire to the standard of care for a random subset of subjects. all subjects who screen positive for hazardous alcohol use will be followed up and reassessed for alcohol use. the researchers hypothesize that the addition of casi will lead to a decrease in alcohol intake within three months. the basis of this research is evidence of the effectiveness in the casi system, the growing public health issue of alcohol abuse, the need to be able to provide effective screening and brief intervention in the high volume ed settings, and findings that the primary method to reduce traumatic death is prevention.


Eligibility criteria:
inclusion criteria: * 18 years or older * trauma and ed patients exclusion criteria: * under the age of 18 * intoxicated * psychiatric
a retrospective study to evaluate the predictability of abnormal arterial blood gas measurements through novel observations of continuous trends in electronically measured respiratory rate in a mixed cohort of respiratory compromised patients

Conditions: Respiratory Failure; COPD; Pneumonia; Community-acquired Pneumonia; COVID-19; Pulmonary Disease

Summary: a retrospective study to evaluate the predictability of abnormal arterial blood gas measurements through novel observations of continuous trends in electronically measured respiratory in a mixed cohort of respiratory compromised patients.


Eligibility criteria:
inclusion criteria: * respiratory condition is the primary admission diagnosis exclusion criteria: * pregnant patients in their 2nd or 3rd trimester

Keywords: respiratory rate arterial blood gas