Kornimate/medical-research-clean huggingface dataset:
the role of sensory processing sensitivity in pediatric chronic pain

Conditions: Chronic Pain

Summary: the aim of this project is to increase scientific understanding of whether the trait of sps can help explain increased pain sensitivity and hence vulnerability for chronic pain. additionally, it will be tested whether participants with high sps report differences in pain intensity in response to positive, negative, or neutral mood induction compared to individuals with lower sps.

background: pain is defined as an unpleasant sensory and emotional experience and in its chronic form, pain is highly prevalent, up to 25% of children and adolescents are affected by it. the exact etiology of many forms of chronic pain remains unknown. one mechanism that has been proposed to underlie increased pain sensitivity is central sensitization, i.e., increased efficacy of the nervous system in transmitting pain signals, which manifests itself as a lower pain threshold. a lower pain threshold in turn has been recognized as a risk factor for the development of chronic pain. being more sensitive to pain is one feature commonly shared by those with high sensory processing sensitivity (sps), who are thought to react more strongly to both positive and negative environmental influences. the relationship between this increased sensitivity and pain tolerance has not been studied to date, but could contribute to our understanding of why some children and adolescents are more vulnerable to developing chronic pain than others. objectives and aims: the aim of this project is to increase scientific understanding of whether the trait of sps can help explain increased pain sensitivity and hence vulnerability for chronic pain. additionally, it will be tested whether participants with high sps report differences in pain intensity in response to positive, negative, or neutral mood induction compared to individuals with lower sps. methods: to examine differences in pain perception of an experimentally induced pain stimulus between people with varying levels of sps and whether pain perception can modulated by positive, negative, or neutral mood induction, i will apply a heat pain paradigm in a sample of healthy adolescents. participants will be randomized to either neutral, positive or negative mood induction and i will test whether their pain sensitivity differs as a function of their scores on a high sensitivity scale and with regard to mood induction. expected results: we expect highly sensitive adolescents to have a lower pain threshold and tolerance and to react more strongly to positive (with decreased pain ratings) and negative (with increased pain ratings) mood induction compared to those with lower scores on the sensitivity scale.

Eligibility criteria:
inclusion criteria: * healthy adolescents aged 16-19 years exclusion criteria: * chronic pain or another chronic condition * skin pathologies * sensory abnormalities affecting the tactile or thermal modality * pregnancy * current medication * current psychological or psychiatric treatment * insufficient language skills to understand the instructions

Keywords: sensory processing sensitivity
study of overactive bladder in women with prolapse

Conditions: Urinary Bladder, Overactive; Pelvic Organ Prolapse

Summary: pelvic organ prolapse (pop) is a common problem. symptoms of overactive bladder (oab) are present in approximately 50% of patients with pop. for many women the accompanying symptoms of oab are an important reason for seeking help for their pop. surgical repair of prolapse may improve oab complaints. persisting or de novo oab symptoms are strongly correlated with dissatisfaction with the final results of an operation for pop. the primary aim of this research project is to investigate the difference in prevalence (i.e. improvement) of oab and bothersome oab symptoms at 6 and 12 months after pop repair surgery. the secondary objectives are to determine changes in bladder function at 6 and 12 months after surgery and to identify predictive factors for persistence, disappearance or de novo symptoms of oab after pop surgery. women who present with pop and who will undergo surgical treatment will be evaluated at baseline before their surgery and will be followed for the duration of one year after surgery.


Eligibility criteria:
inclusion criteria: * female patients, age 18 or greater, with a pelvic organ prolapse stage ii to iv as defined by the pop-q system * patient is a candidate for prolapse repair surgery (as based on history and physical examination) * patient is capable to fill out bladder diaries and questionnaires and understands the dutch written and spoken language exclusion criteria: * patients who currently use anticholinergic medication * patients with neurological causes of oab * patients who are pregnant * patients with a history of cancer in the pelvic region, treated with radiotherapy or surgery

Keywords: urinary bladder, overactive pelvic organ prolapse gynecologic surgical procedures urodynamics
caspa: cardiac sarcoidosis in papworth

Conditions: Interstitial Lung Disease; Pulmonary Sarcoidosis; Cardiac Sarcoidosis

Summary: sarcoidosis is a disease of unknown cause which affects adults of all ethnic backgrounds. clumps of tissue called granulomas develop primarily in the lungs, but can damage other organs, especially the heart. anecdotal evidence from autopsy studies suggests the heart is affected in up to 68% of patients, but there is much uncertainty about this figure. if undetected and untreated, it can lead to serious complications or even sudden death. the current recommendation is to perform heart tracings (ecg s) on all patients, but this detects fewer than half of those with heart involvement. blood markers traditionally used to diagnose heart disease are unreliable, meaning there is no simple blood test in use. the investigators propose a study with three aims. firstly, identify the true prevalence of heart disease by performing magnetic resonance imaging (mri) scans on a group of patients with newly diagnosed lung sarcoidosis. those found to have heart disease will have specialist (but routine) electrical heart tests. secondly, (and perhaps the most immediate and clinically relevant) to identify the best method of diagnosing heart involvement using a combination of three simple tests: advanced ecg, 24-hour continuous ecg and a new type of computerised ultrasound scan. thirdly, to identify proteins in the blood that could be used to develop a simple blood test for heart involvement in patients with lung sarcoidosis.


Eligibility criteria:
inclusion criteria: * newly referred adult patients with pulmonary sarcoidosis and diagnosis made at multidisciplinary meeting as per current joint bts/ats guidance * patient may be on ≤10mg prednisolone at time of recruitment (if already started at another site prior to referral). * able to give informed consent and able to comply with protocol * ≥\>18 yrs exclusion criteria: * history of other cardiac disease (e.g. coronary artery disease)cardiac surgery or previous myocardial infarction (mi) * inability to give informed consent * \<18 yrs * patient may be on \>10mg prednisolone at time of recruitment (if already started at another site prior to referral). * on non-steroidal medication including methotrexate * pregnancy * alcoholism * illicit drug abuse exclusion criteria for mri: * cardiac pacemakers * surgical clips in the head (particularly aneurysm clips) * electronic inner ear implants (bionic ears) * ocular metal fragments • electronic stimulators • implanted pumps * severe claustrophobia

Keywords: sarcoidosis cardiac mri echocardiography pulmonary cytokine
adjuvant peritoneal dialysis on a background of thrice-weekly hemodialysis

Conditions: Functionally Anuric; Hemodialysis/Peritoneal Dialysis

Summary: 1. to assess the feasibility and safety of applying a 12-week course of adjuvant low-frequency icodextrin-based peritoneal dialysis to an ongoing regimen of thrice-weekly in-center hemodialysis. hypothesis: icodextrin-based peritoneal dialysis can be safely and feasibly implemented in the context of ongoing thrice-weekly in-center hemodialysis. 2. to measure the effects of a 12-week course of adjuvant low-frequency icodextrin-based peritoneal dialysis to ongoing thrice-weekly maintenance hemodialysis on: inter-hemodialytic weight gain, achievable hemodialytic dry weight, total body water, ambulatory blood pressure, serum phosphorus, and pre-to-post hemodialysis changes in serum potassium and ph, and kidney disease quality of life-sf physical functioning, energy fatigue, and general health scores. hypotheses: addition of adjuvant icodextrin-based peritoneal dialysis will: 1. reduce inter-hemodialytic weight gain\* 2. enable achievement of lower hemodialytic dry weight 3. reduce total body water 4. improve ambulatory blood pressure control 5. reduce serum phosphorus 6. minimize per-hemodialytic changes in serum potassium and ph 7. have favorable effects on indices of physical function and global health * indicates co-primary outcomes.


Eligibility criteria:
inclusion criteria: * patients who are functionally anuric (urine volume \<100ml/day) * receiving chronic maintenance dialysis for treatment of end-stage renal disease * transitioning from hemodialysis (hd) to peritoneal dialysis (pd) * transitioning from pd to hd * receiving pd and have a functional arteriovenous access already in place exclusion criteria: * \< 18 years of age * anticipate living related kidney transplant or transfer of care away from a participating unit within the next 6 months * have anticipated survival \<6 months * have contraindications to pd therapy * history of complicated bowel or abdominal aortic surgery * known abdominal wall defects * pregnancy (including pre-menopausal women not surgically sterilized or on hormonal contraception) * indwelling trans-abdominal prosthetic devices (e.g., feeding or biliary tubes) * known hypersensitivity to peritoneal dialysate

Keywords: hemodialysis/peritoneal dialysis functionally anuric icodextrin kidney disease quality of life
comfort operative ocular light study

Conditions: Cataract

Summary: digital 3d microscopes require less light and may be more comfortable for patients requiring cataract surgery under topical anesthesia compared to conventional microscopes. to date, no studies have evaluated the comfort and subjective visual sensations related to the light of the 3d digital microscope in cataract surgery patients. the purpose of this study is to evaluate the effectiveness of the ngenuity 3d digital operating system (alcon, fort worth, tx) compared to conventional microscopes on the comfort and subjective visual sensations related to of patients undergoing initial cataract surgery under topical anesthesia (pure or combined with intravenous sedation).

patients will be recruited during the preoperative consultation where the indication for cataract surgery. the allocation of the management arm (3d digital microscope or conventional microscope) will be randomized in a stratified way on the center. prior to his or her operative session, the surgeon will set up the microscope with his or her usual parameters. the light intensity will be measured at the beginning of the operating session with a calibrated light meter. the type of anesthesia (pure topical or associated with intravenous sedation), the duration of the operation, intraoperative complications (frequency and type), and the possible use of an anesthesiologist to inject additional intravenous anesthetic will be collected. before the patient is discharged from the ambulatory surgical unit, the clinical study technician will ask the patient the 4 questions of the standardized questionnaire assessing comfort and subjective visual sensations related to the microscope light.

Eligibility criteria:
inclusion criteria: * indication for a first surgery (= first eye to be operated) of cataract alone under topical anesthesia (pure or associated with intravenous sedation) * express consent to participate in the study exclusion criteria: * patient benefiting from a legal protection measure * patient with comprehension problems or who does not understand french well * pregnant or breastfeeding woman * indication for another surgery on the operated side (e.g. vitrectomy combined with cataract surgery)

Keywords: ngenuity 3d digital operating system
evaluation of the effectiveness of vaccination with 2009 h1n1 vaccines during influenza season 2010-11

Conditions: Influenza Caused by the 2009 H1N1 Influenza Virus

Summary: a cohort of 3000 adults is followed to evaluate the effectiveness of the monovalent 2009 h1n1 vaccines used 2009-2010 and seasonal influenza vaccines used 2010-2011 in preventing the first laboratory-confirmed 2009 h1n1 influenza during the influenza season 2010-11.

in the beginning of the study, changes in the background information collected in the original study (conducted 2009-2010) are asked with a questionnaire. information on influenza vaccinations is collected with vaccination cards and monthly short message service (sms), and verified in registers, if needed. if an epidemic caused by the 2009 h1n1 virus starts in finland, the participants are asked to actively report symptoms of influenza like illnesses (ili). the symptoms are also monitored by weekly sms. in case of ili, nasal and oral swabs are collected to verify the 2009 h1n1 influenza cases. paired serum samples are collected at the acute on convalescence phase of the disease. the occurrence of laboratory-confirmed 2009 h1n1 influenza cases is compared between vaccinated and not (yet) vaccinated persons.

Eligibility criteria:
inclusion criteria for the interview follow-up: * participating in the study "evaluation of a vaccination campaign with a(h1n1)v pandemic vaccines: a prospective cohort study" (ah1n1-483-09thl) * assigned to use the services of tampere health care centre; * written consent for the interview follow-up phase obtained by mail; * able to adhere to all protocol-required study procedures without any special burden or risk, as judged by the participant himself/herself inclusion criteria for the confirmation of 2009 h1n1 influenza cases: * participating in the study interview follow-up of the current study 'evaluation the effectiveness of vaccination with 2009 h1n1 vaccines during influenza season 2010-11 (h1n1-495-10thl) * assigned to use the services of tampere health care centre * written informed consent for the confirmation phase obtained at the first study visit * able to adhere to all protocol required study procedures without any special burden or risk, as judged by the investigator or designate exclusion criteria: * no specific exclusion criteria will be applied

Keywords: 2009 h1n1 influenza vaccination pandemic effectiveness
earliest lung ultrasound time for predicting the need of surfactant

Conditions: Respiratory Distress Syndrome

Summary: lung ultrasonography (lus) is fast and easy technique. it also has high reliability, so it has started to be used more in evaluating respiratory distress in the neonatal period. the most important feature of lus is being radiation-free. three lus findings that show respiratory distress syndrome were described. they were white lung appearance, lack of preserved areas and loss of pleural integrity. the sensitivity of these findings was found to be 98-100% and the specificity 92-100%. a few studies have shown that surfactant need can be determined by lus. it was observed that lung findings were more severe in lus performed in the early period because of non-completed fetal lung fluid clearence, but the findings could be improved during follow-up. therefore, it is not known when the earliest time of lus shows the actual clinical condition and course of the patient. this study was planned to find the most reliable and earliest us time. evaluation with lus was done at 30 minutes and repeated at 1, 2, 4 and 6 hours of life. the lus findings would be compared with x-ray findings and the correlation of surfactant need with lus findings would also be investigated.


Eligibility criteria:
inclusion criteria: * preterm babies with a gestational age 32 weeks or less * babies treated with cpap exclusion criteria: * if a baby was intubated in delivery room because of the responsiveness to face-mask ventilation, he/she was excluded. * congenital heart diseases * complex congenital malformations * chromosomal abnormalities.
global non-interventional heart failure disease registry

Conditions: Acute Heart Failure

Summary: the clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (hf) or decompensation of chronic hf are poorly understood worldwide. report-hf is a global, prospective, and observational hf disease registry designed to characterize patient trajectories longitudinally during and following an index hospitalization for acute hf.


Eligibility criteria:
inclusion criteria: patients at least 18 years old, or older for those countries where the adult age is above 18 years of age, hospitalized with a primary diagnosis of acute heart failure. exclusion criteria: 1-concomitant participation in any/a clinical trial with any investigational treatment (for any sponsor). 2. use of investigational drugs within 5 half-lives of enrollment, or until the expected pharmacodynamic effect has returned to baseline, whichever is longer.

Keywords: registry heart failure hospitalized global morbidity mortality quality of life ahf
systolic hypertension in the elderly program (shep)

Conditions: Cardiovascular Diseases; Cerebrovascular Disorders; Heart Diseases; Hypertension

Summary: the primary objective was to assess whether long-term administration of antihypertensive therapy to elderly subjects with isolated systolic hypertension reduced the combined incidence of fatal and non-fatal stroke. the secondary objectives were to evaluate: the effect of long-term antihypertensive therapy on mortality from any cause in elderly people with isolated systolic hypertension; possible adverse effects of chronic use of antihypertensive drug treatment in this population; the effect of therapy on indices of quality-of-life; the natural history of isolated systolic hypertension in the placebo population.

background: more than 3 million persons in the united states over the age of 60 have isolated systolic hypertension. they face an excess risk (2-3 fold) of stroke, other cardiovascular disease and death. population-based data show that the prevalence rises from approximately 8 percent in the age group 60-69 years to approximately 20 percent over the age of 80. based on available data, an annual stroke rate of 2.0 percent has been estimated in this population. the full-scale clinical trial followed a pilot study conducted from 1980 to 1983. recruitment in the trial began in march 1985 and was finished in january 1988. follow-up ended in february 1991. data analysis continued through october 1996. design narrative: a randomized, double-blind trial in which 2,365 subjects were assigned to active treatment and 2,371 to placebo. for the active treatment group, a stepped-care regimen was used which included chlorthalidone 12.5 or 25 mg/day, and as needed, addition of atenolol 25 or 50 mg/day or reserpine, 0.05 or 0.10 mg/day. treatment goal was to reduce systolic blood pressure by at least 20 mm hg from baseline and to below 160 mm hg with minimal amounts of study medication. the primary endpoint was the incidence of fatal and non-fatal stroke. secondary endpoints were cardiovascular and coronary morbidity and mortality, all-cause mortality, and quality-of-life measures.

Eligibility criteria:
men and women, aged 60 or over, with isolated systolic hypertension.
finding early rheumatoid arthritis

Conditions: Joint Pain; Stiffness

Summary: research has shown that early aggressive use of medicines may stop rheumatoid arthritis (ra)or slow its damage. the key to this is to find people with early symptoms which could be ra and have them get a diagnosis, treatment and follow-up. this study will recruit persons who've gone to the internet looking for information about their symptoms. after answering a screening survey, the person with possible symptoms will be linked to the study website for a more detailed symptom questionnaire. after completing that questionnaire the person will receive information about the second part of the study which includes an examination with a rheumatologist (arthritis doctor)and laboratory tests. based on the joint examination and laboratory tests, the rheumatologist will tell the person the likelihood of having ra, and make recommendations and if needed a referral for care and treatment. treatment is not a part of this study. this study will also compare the information on the subject's questionnaires to the doctor's joint examination and the laboratory tests with the hope of developing a simple inexpensive case finding questionnaire.


Eligibility criteria:
inclusion criteria: * joint pain or swelling for less than 3 months * be able to use the internet exclusion criteria: * non english speaking * diagnosis of rheumatoid arthritis

Keywords: joint pain stiffness
early diagnosis of pulmonary nodules

Conditions: Precancerous Conditions; Carcinoma

Summary: this study is intended to determine the positive predictive value (ppv) and negative predictive value (npv) of the multiprotein classifier based on the observed study prevalence of non-small cell lung cancer (nsclc) in the study participants.

patients must present with previously non-diagnosed lung nodules as found on ct. there is no change to the typical standard of care that any of the investigating physicians and/or centers provide the patients enrolled in this study. the data from this study will not be used to diagnose cancer nor be used to influence treatment decisions for the study participants.

Eligibility criteria:
inclusion criteria: * age ≥ 40 years * smoking history: never, former, current * subject undergoing diagnostic evaluation for a lung nodule * subject undergoing evaluation for a lung nodule by a pulmonologist, and/or by a thoracic surgeon * baseline ct scan identifying lung nodule performed within 60 days of subject enrollment * nodule(s) identified by ct scan previously not followed * subject willing to provide informed consent for the collection of blood specimens exclusion criteria: * nodule work-up at the time of enrollment eligibility indicates any prior attempted or completed diagnostic biopsy procedure, such as transthoracic needle aspiration, bronchoscopic biopsy or surgery * a prior ct scan is available that previously identifies the same lung nodule under consideration for study inclusion on the most current ct scan; and the prior ct scan was performed more than 60 days before the current ct scan, irrespective of the candidate nodule's radiographic characterization such as size, density or appearance * current diagnosis of any cancer * prior diagnosis of any cancer within 2 years of lung nodule detection, except for non-melanoma skin cancer * administration of blood products, e.g. packed red blood cells, fresh frozen plasma, or platelets, within 30 days of subject enrollment * history of human immunodeficiency virus (hiv) or hepatitis c

Keywords: precancerous conditions carcinoma
efficacy comparison of two kinds of treatment in treating dry eye caused by meibomian gland dysfunction

Conditions: Dry Eye Syndrome

Summary: this study aims to evaluate the efficacy of intense pulsed light in treating dry eye caused by meibomian gland dysfunction and make a comparison between the traditional treatment.


Eligibility criteria:
inclusion criteria: * patients with dry eye syndrome and diagnosed as mgd exclusion criteria: * an infection or inflammatory disease; * ocular surgical history with in the last 3 months * sgogren syndrome

Keywords: ipl mgd