Kornimate/medical-research-clean huggingface dataset:
effects of oral iron supplementation before vs at time of vaccination on immune response in iron deficient kenyan women

Conditions: Iron Deficiency Anemia

Summary: iron deficiency (id) anemia (ida) is a global public health problem, with the highest prevalence in africa. vaccines often underperform in low- and middle-income countries (lmic), and undernutrition, including id, likely plays a role. recent studies have shown the importance of iron status in vaccine response. intravenous iron given at time of vaccination improved response to yellow fever and covid-19 vaccines in ida kenyan women. whether oral iron treatment would have a similar beneficial effect on vaccine response is uncertain. also, timing of oral iron treatment needs further investigation. the co-primary objectives of this study are to assess 1) whether ida in kenyan women impairs vaccine response, and whether oral iron treatment improves their response; 2) the timing of oral iron treatment to improve vaccine response (prior to vaccination vs at time of vaccination). we will conduct a double-blind randomized controlled trial in southern kenya to assess the effects of iron supplementation on response to three single-shot vaccines: johnson \& johnson covid- 19 (jj covid-19), the quadrivalent meningococcal vaccine (menacwy) and the typhoid vi polysaccharide vaccine (typhim vi). women with ida will be recruited and randomly assigned to three study groups: group 1 (pre- treatment) will receive 100 mg oral iron as ferrous sulfate (feso4) daily on days 1-56; group 2 (simultaneous treatment) will receive matching placebo daily on days 1-28, and 200 mg oral iron as feso4 daily on days 29-56; and group 3 (control) will receive matching placebo daily on days 1-56. women in all groups will receive the jj covid-19 vaccine, the menacwy and the typhim vi vaccine on day 28. cellular immune response and serology will be measured at 28 days after vaccination in all groups.


Eligibility criteria:
inclusion criteria: * willing and able to give informed consent for participation in the trial * female aged 18-49 years * moderate anemia (hb \<110 g/l, but not severely anemic with hb \<80 g/l) * iron deficient (znpp \>40 mmol/mol haem) * anticipated residence in the study area for the study duration exclusion criteria: * major chronic infecious disease (e.g., hiv infection); * major chronic non-infecious disease (e.g., type 2 diabetes, cancer); * chronic medications; * use of iron-containing mineral and vitamin supplementation 2 weeks prior to study start; * covid-19 vaccine or confirmed covid-19 infection within the past 2 years * menacwy vaccine in the past * typhim vi vaccine in the past * pregnant (confirmed by rapid test during screening) * malaria (confirmed by rapid test) à study start will be postponed
comparing newly developed precore needle with conventional fine needle in suspected unresectable pancreatic cancer

Conditions: Pancreatic Cancer

Summary: background: pancreatic cancer is associated with a poor prognosis. therefore, rapid and accurate diagnosis of a pancreatic mass is important to direct patient management. endoscopic ultrasonography-guided fine needle aspiration (eus-fna) is the current standard for sampling pancreatic mass lesions, with diagnostic accuracy of 78% to 95%. but, the eus-fna has some limitations include stromal cell tumors and lymphomas may be difficult to diagnose. to overcome these limitations, a new needle device with procore reverse-bevel technology was developed recently. aims: the objective of this prospective study is to compare the rate of diagnostic sufficiency in the eus sampling by using newly developed procore needle with conventional fna needle in suspected unresectable pancreatic cancer. we will also compare the safety, the yield of histologic core tissue and the cost-effectiveness between these modalities.

patient: newly diagnosed pancreatic cancer patient whose cancer lesion is suspected unresectable in diagnostic imaging such as ct or mri procedure: each eus-guided fna and procore aspiration will performed twice in same patient. the priority of order will be given by randomization assignment. the number of patients required: total sixty five patients will be required.

Eligibility criteria:
inclusion criteria: * patients who agree to participate in research * 18 years of age and older patients less than 80 years old * patients who have suspected unresectable pancreatic cancer in imaging studies exclusion criteria: * contraindication to endoscopy * patients younger than 18 years old or older than 80 years old * bleeding tendency * cardiopulmonary dysfunction * pregnancy
brain electrophysiological patterns in obesity

Conditions: Obesity

Summary: there is growing evidence of behavioural and neurobiological overlaps between obesity and drug abuse. reduction of the amplitude of p300, a component of event-related potentials (erp) elicited by an oddball paradigm, is an electrophysiological characteristic and a marker of vulnerability in substance abuse. we want to determine whether obesity is associated with such electrophysiological features during an auditory oddball paradigm. we postulate that obesity could be associated with electrophysiological abnormalities that could be viewed as a possible vulnerability marker for food addiction.


Eligibility criteria:
inclusion criteria: * the inclusion criteria for the study are men and women aged 20-60 years, bmi 18.5-24.9 kg/m2 for control subjects and bmi\>30 kg/m2 for obese subjects, stable body weight over the previous 3 months, report of sedentary or moderate physical activity exclusion criteria: * the exclusion criteria are pregnancy, post-menopausal women, any physiological or psychological illness that could influence the results, subjects likely to take medical drugs interfering with the electrophysiological parameters of the study, diabetes, hearing disorder, intense physical activity and report or evidence of excessive alcohol consumption, depressive state or eating disorders according to diagnostic and statistical manual of mental disorders (dsm-iv).

Keywords: obesity cognitive process reward p300 erp event-related potential during oddball paradigm brain electrophysiological patterns externalizing factor
tdcs and robotic training in adults with cerebral palsy

Conditions: Cerebral Palsy; Hemiplegia

Summary: the purpose of this study is to improve arm function in adults with hemiplegic cerebral palsy. participants will receive transcranial direct current stimulation (or sham) in combination with upper extremity robotic therapy.

therapy consists of 20 minutes of non-invasive, low-level brain stimulation (transcranial direct current stimulation, tdcs), followed by one hour of shoulder/wrist robotic training. participants will be enrolled in therapy 3 times per week for 12 weeks (or 36 sessions). before and after therapy, participants will receive and assessment of their arm function, as well as an assessment of their brain activity, using electroencephalography (eeg) and transcranial magnetic stimulation (tms).

Eligibility criteria:
inclusion criteria: * participant willing and able to provide informed consent * diagnosis of hemiplegic cerebral palsy * joint mobility: wrist extention (20 degrees), metacarophalangeal and proximal interphalangeal joints (10 degrees) exclusion criteria: * cognitive deficits that impede understanding of study protocol * current medical illness unrelated to cp * visual problems (uncorrected by glasses/contact lenses) * high motor ability in affected arm * severe spasticity * lack of asymmetry in hand function * orthopedic surgery in affected arm within 2 years * dorsal root rhizotomy * botulinum toxin therapy in either upper extremity during last 2 months, or planned during study period * currently receiving intrathecal baclofen * seizure beyond age 2, use of anti-seizure medication, history of epilepsy (in self or first degree relatives), brain surgery, cranial metal implants, structural brain lesion, deices that may be affected by tms (pacemaker, medication pump, cochlear implant, implanted brain stimulator) * true positive response on the transcranial magnetic stimulation safety screen * current use of medications known to lower the seizure threshold * previous episode of neurocardiogenic snycopy

Keywords: robotics upper extremity
the effect of dexmedetomidine on hemodynamic response during double lumen endotracheal intubation

Conditions: Intubation Complication; Tracheal Intubation Morbidity; Anesthesia Intubation Complication; Hypertension; High Blood Pressure; Tachycardia

Summary: the purpose of this study is to evaluate the effect of dexmedetomidine on hemodynamic responses during laryngoscopy and double lumen endotracheal intubation and assess the adverse effect related to complications of dexmedetomidine.

the cardiovascular responses to laryngoscopy and tracheal intubation are mediated by both sympathetic and parasympathetic nervous system. the hemodynamic responses resulting from sympathetic nervous system stimulation are tachycardia, cardiac arrhythmias, hypertension, increased intraocular pressure, increased intracranial pressure, bronchospasm and myocardial ischemia. tachycardia is one of the major predictor of intraoperative myocardial ischemia and causes an imbalance of myocardial oxygen supply and demand. although hemodynamic responses to laryngoscopy and intubation is transient, these effect may be harmful to patients suffering from myocardial and cerebrovascular diseases. the placement of double lumen endotracheal tube may produce similar or greater pressor response than endotracheal tube because of larger sizes and greater carinal stimulation.

Eligibility criteria:
inclusion criteria: * asa physical status i-iii * undergoing elective thoracotomy or thoracoscopy * required left sided-double lumen endotracheal intubation exclusion criteria: * patients with bradycardia (heart rate \< 50 beat per minute) or heart block * suspected of difficult intubation * patients who are at risk for rapid change of hemodynamics * allergic to dexmedetomidine * hepatic or renal impairment (preoperative serum creatinine \> 1.5 mg/dl) * pregnancy
trial to evaluate the efficacy on local anesthesia and safety of 2% lidocaine hcl with different epinephrine concentration in patients undergoing surgical extraction of impacted lower third molars

Conditions: Third Molar

Summary: this study is phase 4 trial which evaluates the safety and efficacy of 2% lidocaine hcl with different epinephrine concentration in patients undergoing surgical extraction of impacted lower third molars


Eligibility criteria:
inclusion criteria: * age over 19 * physical grade 1 or 2 by american society of anesthesiologists (asa) * mesioangular or horizontal angulation categorized by winter classification exclusion criteria: * allergy or hypersensitivity about the investigated products * any infection or edema during the extraction * the following patients: clotting disorder, hyperthyroidism, arteriosclerosis, cardiac insufficiency, other cardiovascular disorders * pregnancy or breast-feeding * any conditions that the investigator considers not to appropriate for this study
an evaluation of a developmentally-based parent training program for children with autism

Conditions: Autistic Disorder

Summary: the purpose of this study is to assess the efficacy of a parent training program in the treatment of social and communication deficits in children with autism. specifically, this study will evaluate a developmentally based parent delivered intervention in the community developed by pacific autism center for education (pace).

there are many treatments that claim to be effective for children with autism; however many of these treatments have not been investigated using scientifically rigorous methodology. a variety of developmentally based parent delivered interventions are gaining popularity as a type of treatment parents utilize to improve symptoms related to their child's diagnosis of autism. pacific autism center for education (pace)is a agency that provides a developmentally based parent delivered intervention in the community. currently, this parent training program has not been evaluated using scientific methodology. investigation into this community delivered treatment and its effectiveness to improve social and communication deficits will aid clinicians in providing better care for children with autism.

Eligibility criteria:
inclusion criteria: * meets dsm-iv-tr criteria for an autism spectrum disorder (pervasive developmental disorder) on the basis of clinical evaluation and the research diagnostic methods * age range between 18 months and 6.11 years * male or female in good medical health * will be starting pace parent training program * intends on continuing pace program for a minimum of 12 weeks exclusion criteria: * medically unstable (e.g., more than one seizure a month) * a medical diagnosis that causes autism like symptomology (e.g., fragile x, down syndrome, angelman's syndrome, tuberous sclerosis, rett's disorder)

Keywords: pace
comparison of obturator nerve block with ultrasound guidance and anatomical signs

Conditions: Succesful Obturator Nerve Block; Bladder Tumor; Bleeding

Summary: comparison of the obturator nerve block in patients undergoing transurethral resection due to bladder tumor, technically using ultrasound guided or blinded with anatomical signs.

the primary aim of this study is to compare the success rates of onb techniques performed with ultrasound guided or blind technique. its secondary purpose is to compare the effect of peroperative bleeding and control cystoscopy performed in the postoperative 3rd month on the presence of recurrent tumor.

Eligibility criteria:
inclusion criteria: * asa i-ii patients exclusion criteria: * tumors that disrupt the integrity of the bladder, * bladder floor tumors, * coagulation disorders, * motor in the lower limbs * with sensory disturbances, * uncooperative patients, * known allergy to local anesthetics * patients with localized infection at the procedure site

Keywords: obturator nerve block bladder tumor ultrasonografi anatomical signs
longitudinal study of different surgical approaches in chinese patients of uterine cervical cancer

Conditions: Uterine Cervical Neoplasms; Laparotomy; Laparoscopy; Survival; Mortality; Recurrence

Summary: this multi-center longitudinal study aims to compare the survival outcomes (including overall survival, progression-free survival and disease-free survival between uterine cervical patients receiving different surgical routes (vaginal, laparotomy and laparoscopy), which is the primary study objective. all clinical and pathological data would be retracted from case reviews, and all survival data would be reached by clinic, telephone and mail follow-up. this study also would analyze the impact on survival outcomes of other factors, including nerve-sparing techniques, neoadjuvant chemotherapy, neoadjuvant radiotherapy and infection of human papillomavirus. the predictive effects of different following protocol and imaging plans will be also compared. last, the influences of surgical routes on the fertility outcomes (pregnancy and its complications) and the ovarian reserve are important secondary study objectives.


Eligibility criteria:
inclusion criteria: * pathological confirmed as uterine cervical cancer * having definite clinical information * having received radical hysterectomy or trachelectomy exclusion criteria: * not satisfying any of the inclusion criteria
biomarkers in bone marrow samples from pediatric patients with high-risk acute myeloid leukemia

Conditions: Childhood Acute Basophilic Leukemia; Childhood Acute Eosinophilic Leukemia; Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Minimally Differentiated Myeloid Leukemia (M0); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myelomonocytic Leukemia (M4); Recurrent Childhood Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

Summary: this pilot research trial studies biomarkers in bone marrow samples from pediatric patients with high risk acute myeloid leukemia. studying samples of bone marrow from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.

primary objectives: i. to provide a detailed, molecular map of pediatric high risk acute myeloid leukemia (aml). ii. to identify mutations, expression profile, gene copy number, loss of heterozygosity (loh) status and genomic methylation patterns in order to identify novel changes associated with pediatric aml. iii. to generate fibroblast cell lines in order to obtain germline nucleic acids from marrow specimens from aml patients with induction failure. iv. to identify genomic alterations contributing to induction failure in childhood aml. outline: banked bone marrow samples from diagnosis and remission are used to develop a detailed molecular map of pediatric high-risk acute myeloid leukemia. analysis includes genome single nucleotide polymorphism (snp) genotyping, expression, and methylation profiling.

Eligibility criteria:
inclusion criteria: * diagnosis of acute myeloid leukemia * high-risk disease * treated on cog-aaml03p1 or cog-aaml0531 * meets the following criteria: * initial remission with no known adverse risk factors * high quantity and quality of ribonucleic acid (rna) and deoxyribonucleic acid (dna) available * highly enriched specimens with \>= 50% blast available
association between neuromuscular parameters and functional assessment after acl reconstruction

Conditions: ACL Injury

Summary: the anterior cruciate ligament (acl) injury is common in athletes aged 18 to 35. acl reconstruction (aclr) aims to restore knee stability in the process of returning to sports. post-surgical rehabilitation focuses on optimizing biomechanical parameters, with neuromuscular and functional tests assessing muscle strength, proprioception, and dynamic stability. isokinetic allows the measurement of muscle strength symmetry and proprioception, while the single-leg hop and landing tasks assess functional stability and are predictive of sports resumption and injury prevention. despite progress, concerns remain about neuromuscular factors impacting knee stability, especially during landings, which can increase the risk of secondary acl injuries. this study proposes examining knee strength and proprioception using isokinetic dynamometry, alongside biomechanical assessments from functional tests, to explore their relationship to biomechanical features during landings, at 6-to-12 months post-acl reconstruction. the hypothesis is that better muscle strength and proprioception correlate with improved knee control during landing tasks.


Eligibility criteria:
inclusion criteria: * adult patients, aged 18-40, who have undergone a first acl reconstruction more than 6 months ago and are being followed in a sports medicine care pathway * affiliated with a health insurance plan * information form: non-objection to the use of data for research purposes exclusion criteria: * previous ligament surgery of the lower limbs prior to acl reconstruction * complex ligament injury (lateral ligaments, posterior cruciate ligament) * recent muscle injuries * history of injury to the uninjured knee * pregnant woman * neurological history with residual effects or taking medication that affects balance/coordination * inability to perform a muscular assessment * postoperative complications (deep vein thrombosis, sepsis, stiffness/arthrofibrosis)
predictors of occult atrial fibrillation in 171 patients with cryptogenic tia and minor stroke

Conditions: Cryptogenic Transient Ischemic Attack and Minor Stroke

Summary: retrospective study, single-center, on 171 patients, presented a cryptogenic tia and minor stroke. this study objective is to determine profitability of holter 21 days for screening paroxystic acfa / flutter in cryptogenic tia/minor stroke, and identify the predictive factors of discovery a paroxystic acfa on holter 21 days. clinical and échocardiographics factors, and brain imaging (scanner and mri) will be analyzed.


Eligibility criteria:
inclusion criteria: * cryptogenic tia/minor stroke * age \> 18 years * medical care in neuro vascular unit of ch versailles * holter 21 days performed exclusion criteria: 1. acfa history 2. ecg or telemetry who showed acfa before the holter initializing 3. carotid stenosis / symptomatic vertebral 4. arterial dissection 5. prothrombotic state demonstrated by laboratory tests 6. infective endocarditis
conservative management of symptomatic pelvic organ prolapse using vaginal pessaries: generation of a standardized management protocol

Conditions: Pelvic Organ Prolapse; Quality of Life

Summary: genital prolapse is a common condition (up 20%), affecting the quality of life. treatment can be surgical or conservative using vaginal pessaries. these devices are introduced into the vagina aiming to reduces the prolapse. pessaries have shown effectiveness in improving symptoms and quality of life. there are no randomized studies comparing them with surgery. this study design would be difficult to perform, because the inclusion criteria for both treatments are different. there are no currently standard protocols for the use of pessaries. this makes harder to widespread the usage of this conservative treatment. the aim of the investigators is to identify variables that influence the success of conservative management of genital prolapse at 1 year of follow up. using these variables and an expert panel opinion the investigators will develop a standardized protocol for pessary management. chile has a primary gynecological care system based midwives. therefore having algorithms for pessaries usage becomes relevant. this algorithm can be implemented with basic training. this would increase the respond capacity, by the health care system to this disease, considering the scarce access to surgery. the investigators hypothesis is: it is possible to generate a standardized protocol of conservative management of symptomatic genital prolapse in patient's beneficiary of public health system in santiago, chile, using pessaries through a prospective cohort study based in the success of these devices with 1 year of follow up, measured with questionnaires of symptoms, quality of life and sexuality


Eligibility criteria:
inclusion criteria: * symptomatic pelvic organ prolapse * commitment to attend controls * current negative cervical cytology * informed consent signed exclusion criteria: * urinary incontinence as the only pessary indication * vaginal bleeding of undetermined cause * unable to return to controls

Keywords: pelvic organ prolapse quality of life symptoms pessary treatment