Kornimate/medical-research-clean huggingface dataset:
icancope with pain: a smartphone and web self-management program for adolescents and young adults with chronic pain

Conditions: Chronic Pain

Summary: chronic pain in adolescents and young adults (aya, aged 15-25) is a common problem. pain that is not treated properly can reduce quality of life. programs to help aya learn to live with and manage pain are very important. our team is developing a smartphone application (app) and website for aya with chronic pain. the app will help aya to track pain, sleep, mood, activities, and exercise and help aya set and achieve goals. the website will give information about pain and how to manage it independently. we will build the program and make sure it is easy to use and understand. we will also test if the program can be put into practice as planned and if aya using the program feel less pain, have less limitations, and a better quality of life.


Eligibility criteria:
inclusion criteria: * diagnosed with chronic pain of at least 3 months duration according to medical chart * able to speak and read english * willing and able to complete online measures * participants are active patients at pain clinic at one of the respective participating study sites * have access to an internet-connected computer according to self-report. exclusion criteria: * moderate to severe cognitive impairments, as assessed by reviewing medical chart and consultation with the patient's healthcare provider * major co-morbid psychiatric (e.g. conversion disorder, depression, anxiety disorder) illness that may impact patient's ability to understand and use the icancope with pain intervention via self-report, as determined by their health care provider * patient from the department of haemology/oncology * participated in the phase 2b icancope usability study * requires urgent cbt treatment as per their health care provider * individuals who have received more than 4 cbt sessions for pain management in the past 6 months, as per their health-care provider and self-report
intraperitoneal lidocaine in ovarian cancer surgery

Conditions: Ovarian Cancer; Post Operative Pain

Summary: the main objective of this trial is to improve the postoperative analgesia effect and prognosis of patients with ovarian cancer after laparotomy surgery. this is a randomized, double-blind, controlled trial to evaluate analgesia and patient outcomes after local peritoneal anesthesia after surgery.

this is a prospective, randomized, controlled clinical study. sixty patients were expected to participate in a centralized randomized study method divided into two groups of 30 patients per group: the intraperitoneal analgesic group and the normal saline control group. standard routine anesthesia was performed in both groups using the same method, and intravenous analgesia pump was routinely used in clinical use after surgery. the intraperitoneal analgesic group was continuously pumped with local anesthetics into the abdominal cavity, while the control group was pumped with normal saline. visual analogue pain score (vas), amount of remedial analgesia and use of analgesia pump were recorded at 1, 2, 4, 8, 12, 24, 36, 48, 60 and 72 hours after operation. record the time when the patient began drinking and eating, and the time when gastrointestinal function (defecation or exhaust) recovered. the time of starting to walk on the ground (including the time of needing attendant assistance or not) and the time of meeting the standard of postoperative discharge preparation. perioperative peripheral blood samples were collected for five times (t0 before anesthesia induction, t1 after tracheal extubation, t2 on the morning of the first postoperative day, t3 on the morning of the second postoperative day, and t4 on the morning of the third postoperative day), and inflammatory factors and tumor-related indicators were monitored. adverse reactions were recorded. the prognosis of the patients was followed up 5 years after operation.

Eligibility criteria:
inclusion criteria: * the american society of anesthesiologists (asa) rated them as grade i to ii, aged 18 to 75 years. * patients undergoing elective laparotomy for ovarian cancer reduction (surgical resection includes the whole uterus with or without double adnexa, lymph node biopsy, dissection, appendectomy, etc.). exclusion criteria: * suffering from mental illness or unable to cooperate with pain and related index scoring, unable to use automatic pump. * peritoneal infection existed before surgery * past history of arrhythmia * severe liver and kidney dysfunction existed before surgery * known allergy to local anesthetics * do not agree to participate in the research

Keywords: postoperative intraperitoneal lidocaine intraperitoneal analgesic ovarian cancer prognosis
"point of care" ultrasound and renal colic

Conditions: Renal Colic

Summary: the management of renal colic in emergency departments follows the recommendations established at the 8th consensus conference of 2008 on the management of renal colic in emergency services. it recommends the control of pain by nonsteroidal anti-inflammatory drugs and analgesics, the implementation of an urinary test strip and the use of emergency imaging for compiled forms and patient with medical specificities. currently, two imaging techniques are recommended during an episode of renal colic: 1. abdominal x-ray/ultrasound or non-injected scanner for simple forms to be performed within 24-48h 2. the non-injected scanner for complicated forms in simple forms, the decision to perform any examination remains at the discretion of the physician but with a tendency to carry out a scanner systematically even in the absence of criteria of severity or complication. the use of the scanner exposes the patient to large doses of radiation even if it is a low dose scanner. in recent years, studies have been conducted to determine whether the ultrasound, particularly "point of care" ultrasound performed by an emergency physician could be an alternative in the management of renal colic. studies show that the sensitivity and specificity of ultrasound is comparable to that of the scanner. it has been found that the performance of an ultrasound by the emergency physician allows the decrease in irradiation and also in costs. in 2014,a study published in the new england journal of medicine emphasized that the ultrasound performed by the emergency physician would perform just as well as that performed by the radiologist and would result in a decreased time in the emergency room. the korean study, published in 2016 in the clinical and experimental emergency medicine (ceem), despite some statistical inconsistencies, shows a significant reduction in the time of care by 74 minutes. in this context, we would like to conduct a single-centre, randomised, controlled, open-label study comparing a group of patients benefiting from point of care ultrasound versus a group of patients not benefiting from it. the goal is to determine whether the early ultrasound performed by the emergency physician by detecting expansions of the pelvicalyceal cavities reduces the time spent in the emergency department.


Eligibility criteria:
inclusion criteria: * adult patients admitted in er for suspicion of simple renal colic * signed informed consent exclusion criteria: * protected adults (tutorship or guardianship) * fever ≥ 38.5°c * chronic endstage kidney failure (glomerular filtration rate \< 30%) * solitary kidney * urinary tract catheter or percutaneous nephrectomy * pregnancy * traumatic back pain * renal colic diagnosis in the past three months

Keywords: ultrasound renal colic emergency room point of care
single gene polymorphisms associated with molar-incisor hypomineralization

Conditions: Molar-Incisor Hypomineralization

Summary: the genetic factors associated with molar-incisor hypomineralization (mih), a dental condition affecting permanent molars in individuals aged 8-13. buccal swab samples collected from 90 mih-affected participants and 90 systemically healthy controls. the goal is to identify potential genetic markers contributing to the etiology of mih, shedding light on previously unexplored aspects of genetic susceptibility.

the aim of study is to elucidate the unknown aspects of genetic predisposition that may be effective in the etiology of molar-incisor hypomineralization (mih), that is, to identify unexplored genes that may be associated with mih. the buccal swab method will be used for the purpose of collecting dna samples.samples will be collected from the inner cheek using a swab. the collected samples will be placed in single-use sterile eppendorf tubes containing phosphate buffered saline (pbs) solution. the samples will be stored at +4 degrees celsius in a refrigerator, and dna isolations will be performed within a few days. .

Eligibility criteria:
inclusion criteria: * patients aged between 8 and 13 years * patients whose parents consent to participate in the study * patients who provide cooperation for treatment and study * for the study group: patients with at least one molar tooth showing molar-incisor hypomineralization * for the control group: patients without molar-incisor hypomineralization * patients without a genetic disease in themselves or their family exclusion criteria: * patients with a genetic disease in themselves or their family
study to analyze the efficacy of chronic intake with a β-alanine supplement in recreational cyclists

Conditions: Beta Alanine Supplementation

Summary: randomized, controlled, double-blind, single-center, controlled clinical trial with three parallel arms depending on the product consumed (experimental product dose 1 and dose 2 and placebo product) to measure the efficacy of 28-day consumption of a sustained-release beta alanine on the physiological efficacy of physical performance in recreational cyclists.

subjects meeting the selection criteria will be randomly assigned to each of the study groups (investigational product dose 1 or dose 2, or placebo, depending on the group to which they have been assigned). the product to be consumed is beta alanine. participants will consume the product for 28 days. they will have to take 4 intakes every three hours, the first intake being two hours after waking up. the study subjects will have to make 2 visits to the laboratory. physical performance and physiological changes will be evaluated with a 10-minute time trial. the first test will be performed without product consumption and the second after 28 days of consumption.

Eligibility criteria:
inclusion criteria: * male cyclists with more than two years of cycling experience. * perform tests without fatigue. * road bike training at least twice a week. exclusion criteria: * participants with chronic illness. * have a long-term injury that prevents you from training in the previous month. * inability to understand informed consent. * have consumed beta alanine in the three years prior to the start of the study. * consumption of other supplements that may alter performance.

Keywords: chronic effect beta alanine
modified versus traditional thoracic drainage after thoracoscopic surgery

Conditions: Lung Neoplasms; Lung Cancer; Pulmonary Neoplasm; Postoperative Pain; Thoracoscopic Surgery

Summary: lung cancer is the leading cause of cancer-related death worldwide. thoracoscopic pulmonary resection is a prevalent management for early stage of lung cancer. placement of traditional chest tube is the standard procedure after surgery, which causes pain that cannot be ignored. we aimed to determine whether a modified thoracic drainage strategy based on pigtail catheter associated with better clinical results compared with traditional methods after thoracoscopic surgery for lung cancer.


Eligibility criteria:
inclusion criteria: * 18\<age\<80; * patients with lung cancer; * thoracoscopic lung resection; * single chest-tube insertion. exclusion criteria: * a history of preoperative chemotherapy or radiotherapy; * presence of distant tumor metastasis; * pneumonectomy; * dysfunction of cardiorespiratory system or other surgical contraindications.

Keywords: chest tube pigtail catheters chest tube drainage thoracic drainage lung cancer thoracoscopic surgery pulmonary neoplasm
novel detection system for lung cancer curative effect monitoring

Conditions: Lung Neoplasms

Summary: the purpose of this study is to investigate the sensitivity，specificity and concordance rate of egfr testing results in plasma in comparison of results in matched tumor tissues tested by amplification refractory mutation system(arms). moreover, the investigators correlate our findings in plasma with survival of advanced patients.

non-small cell lung cancer (nsclc), accounting for 80% of all lung cancers, is a leading cause of cancer deaths worldwide. inhibition of epidermal growth factor receptor (egfr) kinase activity by egfr tyrosine kinase inhibitors, such as gefitinib and erlotinib, can result in improved response and prolonged progression-free survival (pfs) in selected non-small cell lung cancer (nsclc) patients harboring sensitizing egfr mutations, especially the exon 19del and exon 21（l858r） mutations. unfortunately, about 50%-60% patients who accept egfr tyrosine kinase inhibitors with sensitizing mutations will receive resistance mutations, the t790m resistance is a target of active pharmaceutical development. so egfr mutation testing is a step in identifying the right patients for egfr tyrosine kinase inhibitors treatment. now tissue samples and tumor cytologic samples are accepted as appropriate sample types for egfr mutation detection, but these samples are not always available on or after diagnosis, and, even when available, they may be of insufficient quality or quantity for mutation testing. noninvasive techniques for tumor genotyping may be needed to fully realize, such as plasma sample. cell-free dna (cf-dna) in plasma is a kind of fresh and realtime sample, and has been shown to be promising for the detection of sensitizing egfr mutations even the resistance mutation（t790m). however, a challenge was also raised about how to detect the low abundance of mutant alleles in plasma. in our study droplet digital polymerase chain reaction and realtime polymerase chain reaction will be used to assess the egfr mutation in plasma dna samples from patients with advanced nsclc before and after egfr tyrosine kinase inhibitors therapy.

Eligibility criteria:
inclusion criteria: 1. aged 18-85 years old; 2. the diagnosis of lung cancer by pathological examination; 3. at least one specific measurable lung cancer lesions (according to recist criteria, application of spiral ct, the lesion diameter 10 mm or higher); 4. people understand and are willing to accept the study, and sign the informed consent exclusion criteria: 1. with severe hemorrhagic disease; 2. compliance is poor, can't cooperate with the visitor.

Keywords: lung neoplasms digital polymerase chain reaction
partner notification for chlamydia in primary care

Conditions: Chlamydia Infections

Summary: the purpose of this study was to compare the effectiveness of partner notification by general practice nurses with referral to a specialist clinic for people with genital chlamydia diagnosed in a community setting. we hypothesised that referral to a specialist would be more effective in ensuring treatment of the sexual partners of infected people than the simpler nurse-led strategy.

partner notification (contact tracing) is essential to the control of sexually transmitted infections. reports of new chlamydia infections have increased by 66% in the past five years. a national chlamydia screening programme in england, and increasing primary care provision of sexual health care are part of the united kingdom government's strategy for tackling increasing rates of sexually transmitted infections. new strategies for managing chlamydia in non-specialist settings are urgently required: genitourinary medicine clinics are failing to cope with their increasing workload; and 45% of cases detected in the chlamydia screening pilot studies were diagnosed in general practice. partner notification involves informing the sexual partners of someone with a sexually transmitted infection of the possibility of exposure, offering them diagnosis and treatment, and providing advice about preventing future infection. in the united kingdom, this is usually done by specialist sexual health advisers in departments of genitourinary medicine. the effectiveness of partner notification in non-specialist settings in developed countries is not known. we conducted a randomised controlled trial to compare the effectiveness of practice nurse-led partner notification with referral to a genitourinary clinic for partner notification conducted by a specialist health adviser, and to compare the resources used by each strategy. comparisons: partner notification at the time of receiving diagnosis and treatment by general practice nurses who received a one-day training course and ongoing support by telephone calls or visits from a specialist adviser in sexual health, compared with referral to a genitourinary medicine clinic for partner notification by a specialist adviser in sexual health.

Eligibility criteria:
inclusion criteria: * chlamydia trachomatis diagnosed through a population-based screening study * chlamydia test result received at patient's general practice * chlamydia cases diagnosed in general practice exclusion criteria: * none

Keywords: chlamydia trachomatis chlamydia infections randomized controlled trials contact tracing family practice
evaluation and treatment of people with eye diseases

Conditions: Eye Diseases

Summary: this study will evaluate and provide standard treatments for people with various eye conditions. it will provide a resource for enrollment into new research protocols throughout the eye institute and will allow institute specialists the opportunity to maintain their expertise and gain additional knowledge of the course of various eye disorders. the information obtained will allow for the evaluation of standard treatments and may lead to ideas for future research. people with diagnosed or undiagnosed eye disease and first-degree relatives of people with a genetic or developmental eye disease may be eligible for this study. participants are evaluated and treated in the national eye institute. blood or other tissue samples (e.g., urine, stool, hair, saliva or cheek swab) may be collected for future laboratory studies.

the national eye institute (nei) is conducting a study to evaluate and provide standard treatment to participants with various diagnosed and undiagnosed ocular conditions. objectives: the primary objective of this protocol is to provide a reservoir of patients for enrollment into new research protocols throughout the nei laboratories. evaluating and treating participants will allow the nei specialists to maintain their expertise and gain additional knowledge of the course of various eye disorders. the information obtained will allow for the evaluation of standard treatments of the studied eye diseases. this understanding may lead to ideas for future protocols. in some cases, blood or other biologic samples (including tear fluid, urine, saliva, hair, stool or a cheek swab) will be obtained for future laboratory studies. study population: the number of participants to be enrolled has no logical upper limit, but will be set to 5,000 patients with ocular diseases and their unaffected first-degree relatives. design: this is an observational natural history study of multiple ocular diseases and their progression and physiology. outcome measures: no formal outcomes will be measured; however the clinical assessments of enrolled participants can be used to measure the response to standard treatment. in addition, dna samples obtained may be used to identify and verify causative mutations, which may help establish pathogenic mechanisms and genotype-phenotype correlations.

Eligibility criteria:
* inclusion criteria: participants will be eligible if they: * have either a diagnosed or undiagnosed eye disease, or are an unaffected first-degree relative of a participant with a genetic or developmental eye disease. * have the ability to understand and sign an informed consent or have a parent/legal guardian to do so if they are minor children. exclusion criteria: participants will not be eligible if they: * are unable or unwilling to give informed consent. * are unwilling or unable to be followed as clinically indicated. * have a systemic disease that compromises the ability to provide adequate ophthalmologic examination or treatment.

Keywords: evaluation and treatment eye diseases
employing end tidal capnography in continuous flow ventricular assist device patients

Conditions: Cardiomyopathy; Cardiovascular Disease; Heart Disease

Summary: the purpose of this study is to explore how the end tidal carbon dioxide monitoring via nasal cannula (etco2-nc) device may allow for earlier detection of respiratory complications. this device will detect the amount of carbon dioxide exhaled with each breath and may better predict high levels of this than traditional monitoring. this may reduce the number and severity of respiratory issues. a convenience sample of 60 participants either scheduled for continuous flow left ventricular assist device (cf-lvad) implant or who have been readmitted to an icu with a cf-lvad will be recruited and randomized to usual care or usual care plus etco2-nc throughout their stay in the icu.

the purpose of this proposal is to explore the relationships between end tidal carbon dioxide (etco2) via nasal cannula (etco2-nc) and routinely measured physiologic and participant reported parameters in extubated participants who have received a continuous flow left ventricular assist device (cf-lvad), and to determine if the addition of etco2-nc monitoring to usual care is associated with decreased incidence and severity of respiratory issues. a convenience sample of 60 participants either scheduled for mechanical circulatory support device (mcsd) implant or who have been readmitted to an intensive care unit (icu) with a cf-lvad will be recruited and randomized to usual care or usual care plus etco2-nc throughout their stay in the icu. investigators seek to examine the relationship between etco2-nc with traditional physiologic measures, clinical assessments, and participant reported symptoms in persons with a cf-lvad. additionally, this study intends to compare the respiratory outcomes of extubated persons with a cf-lvad randomized to usual care to those receiving usual care plus etco2- nc.

Eligibility criteria:
inclusion criteria: * scheduled for mechanical circulatory support device (mcsd) implant or have been readmitted to an intensive care unit (icu) with a continuous flow left ventricular assist device (cf-lvad) * new york heart association (nyha) functional class iii to iv * ability to read, write, and speak english exclusion criteria: * requiring mechanical ventilation during the active phase of the trial