Kornimate/medical-research-clean huggingface dataset:
fentanyl background infusion for acute postoperative pain

Conditions: Analgesia Disorder

Summary: we investigated the efficacy and the safety of the pharmacokinetic model-based patient-controlled analgesia (pca) regimens of fentanyl for postoperative analgesia after total intravenous anesthesia (tiva).

infusions of fentanyl (2 ml/hr of diluent was equivalent with 0.5 μg/kg/hr of fentanyl) were maintained at the fixed-rate of 2 ml/hr until the postoperative 24 hr, or at the decremental rates of 6.0 ml/hr or 8.0 ml/hr during 1 hr, 4.0 ml/hr during 1\~3 hr and 2.0 ml/hr during 3\~24 hr, postoperatively.

Eligibility criteria:
inclusion criteria: * patients who had undergone patient-controlled analgesia (pca) after hysterectomy exclusion criteria: * neurologic disorders * psychiatric disorders * renal or hepatic disorders

Keywords: analgesia fentanyl total intravenous anesthesia
pharmacokinetic evaluation of fluoroquinolone antibiotics administered intravenously in intensive care patients with normal renal function and with renal hyperfiltration

Conditions: Infection

Summary: at the intensive care unit (icu) fluoroquinolone antibiotics, like levofloxacin, are frequently used for the treatment of infections. adequate blood levels are required for a good efficacy of the antibiotic. due to the fact that levofloxacin is almost completely eliminated renally, the blood levels for this antibiotic are strongly influenced by the renal function. therefore, this study aims to evaluate the pharmacokinetics of levofloxacin in patients with hyperfiltration, in comparison with critically ill patients with normal renal function.


Eligibility criteria:
inclusion criteria: * patients hospitalized at the department intensive care unit who are being treated with levofloxacin i.v. (500mg, twice daily) for an infection. exclusion criteria: * younger than 18 years * no informed consent * no arterial catheter * hematocrit ≤ 21 * pregnancy and lactation * creatinine clearance \< 80 ml/min

Keywords: patients hospitalized at intensive care unit treated with levofloxacin iv
mupirocin-iodophor icu decolonization swap out trial

Conditions: Staphylococcus Aureus

Summary: the swap out trial is a cluster randomized controlled trial of hca hospitals, evaluating the non-inferiority of two decolonization regimens: arm 1 routine care: icu nasal decolonization with mupirocin twice daily for 5 days in the context of chlorhexidine for daily bathing; arm 2 intervention: icu nasal decolonization with iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing note: that enrolled "subjects" represents 137 individual hca hospitals (representing \~235 icus) that have been randomized.


Eligibility criteria:
inclusion criteria: * inclusion criteria includes all u.s. hca hospitals with an adult icu; * note: unit of randomization is the hospital, but the participants are hospital adult icus * all patients within adult icus are included, including rare patients \ =12 years. exclusion criteria: * exclusion criteria includes icus with an average length of stay of less than 2 days; * hca hospitals that are not able to transfer or merge data into the centralized data warehouse for the baseline and intervention periods of the study are also excluded.

Keywords: mrsa healthcare-associated infections mupirocin iodophor resistance
myocardial protection effect of simvastatin undergoing cardiac surgery

Conditions: Congenital Heart Disease; Heart Valve Disease

Summary: statins have been used to low cholesterol to prevent and treat coronary artery diseases. it was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft. the investigators recent found simvastatin reduced myocardial injury during noncoronary artery cardiac surgery in single medical center. the investigators further investigate that whether simvastatin can protect myocardium during noncoronary artery cardiac surgery with cardiopulmonary bypass and improve cardiac function with long term use postoperatively in two medical centers.


Eligibility criteria:
inclusion criteria: * more than 18-year-old, * congenital heart disease(not complex), * isolated heart valve disease, exclusion criteria: * coronary artery disease * allergy for statins * poor liver function,hepatitis * gestation women and breast-feeding women
hcc response assessment by mri after sbrt

Conditions: Carcinoma, Hepatocellular

Summary: the aim of this work was to describe sbrt different presentations, to study predictive factors for tumor responses following treatment, and to compare tumor response assessments according to the response evaluation criteria


Eligibility criteria:
* inclusion criteria: the standard criteria for treating hcc patients with sbrt : an eastern cooperative oncology group (ecog) score of 2, inoperable tumors (e.g. the patient being unfit for surgery, or tumor-related contraindications), and a maximum tumor diameter of 6 cm. the hcc diagnosis could be histological or based on the radiological criteria of the american association for the study of liver diseases (aasld) * exclusion criteria:no follow-up by mr imaging

Keywords: mri stereotactic body radiation therapy
stopping postpartum vitamin a supplementation: missing concealed benefit

Conditions: Vitamin A Deficiency

Summary: the purpose of this study is to evaluate the effect of post-partum maternal vitamin a supplementation on breast milk bioactive compounds and immune status, growth and morbidity of children in the first four months of life.

the effect will be assessed by the milk and blood.

Eligibility criteria:
inclusion criteria: * pregnant women \>-18 years of age with low-risk obstetric exclusion criteria: * pregnant women expecting a multiple birth * take vitamin a supplements during postpartum apart from study intervention * premature birth * newborn babies with birth defects and / or other serious diseases

Keywords: vitamin a breast milk postpartum vitamin a supplementation infant vaccine response
impact of the immune system on response to anti-coronavirus disease 19 (covid-19) vaccine in allogeneic stem cell recipients (covid vaccin allo)

Conditions: Coronavirus Disease 2019 (Covid19); Hematopoietic Neoplasms

Summary: the present study is a prospective phase iv study. all participants will receive the anti-coronavirus disease 2019 (covid-19) vaccine (messenger ribonucleic acid-based vaccine, bnt162b2 or comirnaty®, commercialized by pfizer-biontech) being authorized in the european union since december 2020. the vaccine is administered intramuscularly after dilution as a series of two doses at least 21 days apart.

the central question is whether allo-hematopoietic cell transplantation (allo-hct) recipients can develop protective immunity against covid-19 upon vaccination. this question needs to be answered urgently and would help the hematologist to provide recommendation / best treatment for these patients. in this pilot project cov-allo, this important question will be addressed in a cohort in which allo-hct recipients will be vaccinated with the mrna available covid-19 vaccine according to the belgian vaccination program. the primary objective is to assess immune response after administration of covid-19 mrna vaccine bnt162b2 (comirnaty®; pfizer-biontech) in a population of 50 patients allo-hct recipients. this number is based on the availabilities of vaccines and eligible patients. moreover, as the study is observational and exploratory, no sample size calculation could be provided for this study.

Eligibility criteria:
inclusion criteria: * prior allogeneic hematopoietic stem cell transplantation 3 months to 5 years earlier (any donor type) * age \> or = 18 years at inclusion. * written informed consent exclusion criteria: * hiv seropositivity * pregnancy * active malignant disease at inclusion * current grade iii-iv acute graft versus host disease (gvhd) * in vitro t-cell depletion of the graft if vaccination within the 6 months after transplantation. * rituximab administration in the 6 months prior to study inclusion * prior documented covid-19 infection
feasibility of a digital therapeutic for adults with binge eating and obesity

Conditions: Binge Eating; Obesity

Summary: the primary objective of this study is to test the feasibility of a digital therapeutic to address comorbid binge eating and obesity in adults.

this single-arm, open-label clinical trial will test the feasibility, usability, acceptability, and preliminary efficacy of a digital therapeutic in reducing binge eating and weight in 30 adults with comorbid recurrent binge eating and obesity.

Eligibility criteria:
inclusion criteria: 1. english speaking male or female patients, 18-70 years 2. patients with recurrent binge eating (≥12 episodes in 3 months) and obesity (bmi ≥30) 3. understand written and spoken english 4. own an iphone with ios 11 or higher, or android with os 8.1 or higher 5. willing and able to complete enrollment procedures 6. able to understand the nature of the study and provide written informed consent exclusion criteria: 1. patients with active psychosis 2. patients who are acutely intoxicated at the time of enrollment 3. currently enrolled in other treatment studies for the symptoms and behaviors targeted 4. patients who are cognitively impaired 5. patients who, in the judgment of the investigator, would have an unfavorable risk/benefit profile with respect to the digital therapeutic
combined behavioral and pharmacologic treatment of polydrug abuse

Conditions: Opioid Dependence; Cocaine Abuse

Summary: the primary goal of this study is to determine how contingency management can best be combined with standard or high doses of methadone to increase simultaneous abstinence from heroin and cocaine.

a study of people pmaintained on methadone using contingency management

Eligibility criteria:
inclusion criteria: * opioid dependence; cocaine use exclusion criteria: * medical or psychiatric conditions that would contraindicate participation in a methadone maintenance study; inability to give informed consent; inability to attend clinic seven days a week
esophageal dysmotility - prospective study evaluating methods for esophageal dilation

Conditions: Esophageal Dysmotility

Summary: the purpose of the study is to prospectively evaluate the most effective treatment of esophageal dysmotility that alleviates symptoms of dysphagia and improves quality of life. current practice uses either semi-rigid savary dilators or balloon dilators for esophageal dilation to treat dysphagia due to esophageal dysmotility. the study aims to show which treatment method is more effective in alleviating symptoms, since there are no other treatments available. the null hypothesis is that there is no difference between the clinical benefits of each treatment.

both the savary and balloon dilators are used as routine procedure at university of massachusetts (umass) medical school's academic medical center umass memorial health care (ummhc). gastroenterologists are required as part of their training to be familiar with both types of procedures. this study aims to definitively determine which treatment method is more effective in alleviating the symptoms of esophageal dysmotility. the primary clinical endpoint is to assess the therapeutic efficacy of different types of dilators in an esophageal dilation procedure in patients with esophageal dysmotility. this will be evaluated through the use of the dysphagia scale (knyrim et al, 1993). the secondary aims are to assess time to relapse, diet improvement, as well as change in quality of life. investigators will determine time to relapse by time between the dilation procedures. participants are instructed to contact the gi office to schedule another dilation if they feel as though the therapeutic effect of the procedure has subsided and they are in need of additional relief. diet will be assessed using the diet score (cox et al, 1998) and quality of life will be assessed using the short form (sf) sf-12 health survey. if patients fail the first procedure, they can be offered the alternative procedure at a later date. both the patient and physician must agree that the treatment has not worked, and then the patient will be given the opportunity to cross over to the other procedure, still blinded to the device that will be used. investigators will conduct an interim evaluation to assess the progress of the study and degree of crossover. this will ensure that all subjects are given the opportunity to have both devices used in the event that one is significantly superior to the other.

Eligibility criteria:
inclusion criteria: * \> 18 years old * dysphagia to liquids and/or solids * diagnosis of esophageal dysmotility * normal endoscopic exam exclusion criteria: * diagnosis of achalasia * defined strictures or webs * vulnerable populations: * adults unable to consent (individuals who are not yet adults (infants, children, teenagers), pregnant women, prisoners)
a study to compare the efficacy and safety of ultrasound guided lead implantation for sacral neuromodulation (snm) in subjects with overactive bladder (oab) with x-ray guided technique

Conditions: Refractory Overactive Bladder

Summary: overactive bladder(oab,urgency) was determined by international continence society as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence, in the absence of urinary tract infection (uti) or other obvious pathology.the snm treatment involves a two-stage surgical procedure performed under local anesthesia. the device include ipg (implantable programme generator) and lead. in the initial test phase, 1st stage, electrode is placed near the sacral nerve and requires a 2 weeks assessment. this allows your doctors and you to assess your initial response according to your voiding dairy and satisfaction. in 2nd stage, snm procedure is implantation of the ipg. x ray guidance is harmful to both patients and doctors, while ultrasound guidance is real time visual guidance ,easy to operate by doctors and a radiation free option to challenge anatomy. urologists are skilled in both ultrasound operations and anatomy basics and dedicating to developing better guidance technique in surgery. the study here compare the efficacy and safety of ultrasound versus x ray guidance technique in snm.


Eligibility criteria:
inclusion criteria: 1. age \> 16 years; 2. subjects suitable for snm surgery; 3. normal upper urinary tract function; 4. bladder volume \> 100 ml; 5. good compliance and able to complete the follow-up assessments. exclusion criteria: 1. psychiatric or neurologic disabilities on neurologic evaluation such as multiple sclerosis, spinal cord injury, epilepsy, parkinson's disease, stroke; 2. bladder lithiasis or tumor (cystoscopy or ultrasonography); 3. stress urinary incontinence; 4. bladder outlet obstruction; 5. diuresis \> 3 liters per 24 hours; 6. negative at the test period or previous treatment with snm; 7. pregnancy and plan to be pregnancy in 2 years.
non-invasive and non-contact intracranial pressure waveform recording using dynamic video ophthalmoscopy

Conditions: Intracranial Pressure Increase

Summary: this study will test the use of video ophthalmoscope to provide information about intracranial pressure without the use of invasive methods, anesthesia or contact with the eye.

the monitoring of intracranial pressure (icp) is crucial in head injuries and pathologies such as brain edema, arachnoid cyst, craniosynostosis or, in very-low-birthweight infants, post-hemorrhagic hydrocephalus. some current methods of icp are invasive and, in the case of lumbar puncture, require anesthesia, which can distort the measurement by 5-10 mmhg. the golden clinical standard is direct measurement using a surgically-implanted intraventricular drain connected to an external pressure transducer ("icp probe"). however, this method carries risks such as hemorrhage, malfunction, obstruction or infection . the risk in pediatric patients is up to 5% and in adults the risk of fatal hemorrhage is 4-5% in patients with subdural and intraparenchymal monitoring devices. due to these risks and the financial burden on patients, there have been attempts to develop tools for non-invasive icp estimation. this study will test the use of a video ophthalmoscope that will calculate the relative waveform of intracranial pressure and provide information about intracranial compliance without the use of anesthesia, invasive methods or contact with the eye.

Eligibility criteria:
inclusion criteria: * must be able to sit still and fix their eyes on a target in the vo objective. * icp participants must have an inserted icp probe for clinical purposes. exclusion criteria: * diagnosis of glaucoma, retinopathy or head tremor.

Keywords: video ophthalmoscope intraocular pressure electrocardiogram photoplethysmography retinal pulsatility spontaneous venous pulsation blind source separation
bimatoprost monotherapy vs. dual therapy with travoprost and timolol in patients with glaucoma and ocular hypertension

Conditions: Glaucoma

Summary: evaluate the iop-lowering efficacy and quality of life in patients using bimatoprost 0.03% monotherapy versus dual therapy with travoprost 0.004% and timolol 0.5% for the treatment of glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * · male or female \> 18 years of age * diagnosis of primary open-angle glaucoma or ocular hypertension * untreated iop \> 18 mm hg in each eye at the baseline evaluation * ability to provide informed consent and likely to complete all study visits exclusion criteria: * · known contraindication to bimatoprost, travoprost, timolol, or any component of any study medication * uncontrolled systemic disease * active ocular disease other than poag or ocular hypertension * required use of ocular medications other than the study medications during the study (intermittent use of otc artificial tear products will be permitted) * history of intraocular surgery within the last 3 months * patient must not have discontinued use of any medication included in this study in the past for reasons of efficacy or intolerance
place of glycation in diabetic retinopathy

Conditions: Descriptor

Summary: 1. definition: diabetic retinopathy is a microangiopathic complication of diabetes diabetes mellitus. its pathophysiology includes glycation and intracellular hypoxia. diabetic retinopathy (dr) is a microvascular complication of diabetes. it is the leading cause of it is the leading cause of blindness and visual impairment in people under the age of 60 in industrialized countries. chronic hyperglycemia during diabetes plays a major role in the occurrence of diabetic diabetic retinopathy by promoting protein glycation and the accumulation of glycation end products (gtps). gtps are a heterogeneous group of compounds resulting from non-enzymatic and irreversible reactions between reducing sugars and amine groups of biological molecules such as proteins, lipids or nucleic acids. 2. interest: the aim of our work is to describe the mechanisms by which glycation participates in the pathophysiology of diabetic retinopathy and to discuss the use of ages as biomarkers in this biomarkers in this pathological context and the therapeutic means that limit the toxicity of of ages. the study is designed through a retrospective and prospective observational study to establish the of glycation in the occurrence of diabetic retinopathy. it will describe the demographic demographic profiles, glycemic control, clinical and paraclinical status of patients with diabetic diabetic retinopathy and will evaluate the relationship between glycation and diabetic retinopathy as well as the factors that influence this glycation in these patients, and induce the occurrence and / or of diabetic retinopathy. the data collected will allow to improve the knowledge, the diagnosis and the treatment of diabetic diabetic retinopathy, as well as a good management of the patients who should benefit from a more individualized and individualized and adequate treatment.


Eligibility criteria:
inclusion criteria: * diabetic patients type 1 and type 2, of both sexes, and of all ages. regular follow-up exclusion criteria: * other types of diabetes. irregular follow-up.

Keywords: glycation diabetic retinopathy
airtime incentive amounts to improve interactive voice response surveys in bangladesh and uganda

Conditions: Surveys and Questionnaires; Noncommunicable Diseases

Summary: this study evaluates the effect of two different airtime incentive amounts on interactive voice response (ivr) survey cooperation, response, refusal, and contact rates, as compared to control group, in bangladesh and uganda.

using random digit dialing sampling techniques, the investigators randomized random digit dialed (rdd) participants to one of three airtime incentive amounts contingent on them completing the noncommunicable disease risk factor survey. this mobile phone survey was sent as an interactive voice response (ivr). in ivr surveys, participants use their touch tone key pad to answer pre-recorded questions. (i.e. if you are male, press 1; if you are female, press 2). this study was conducted in both bangladesh and uganda

Eligibility criteria:
inclusion criteria: * access to a mobile phone * greater or equal to 18 years of age * in bangladesh, conversant in either english or bangla language. in uganda, conversant in either luo, luganda, runyakitara, or english languages exclusion criteria: * less than 18 years of age

Keywords: mobile phone surveys interactive voice response incentive
ventilatory strategy for the prevention of atelectasis during bronchoscopy under general anesthesia, vespa trial

Conditions: Lung Disorder

Summary: this trial compares two different types of ventilation for the prevention of partial or complete collapsed lung (atelectasis) in patients undergoing bronchoscopy under general anesthesia. ventilatory strategy to prevent atelectasis (vespa) may work better than standard of care mechanical ventilation to reduce the intra-procedural development of atelectasis during bronchoscopy under general anesthesia.

primary objective: i. to determine if our ventilatory strategy to prevent atelectasis (vespa) can reduce the intra-procedural development of atelectasis during bronchoscopy under general anesthesia when compared with conventional mechanical ventilation. secondary objectives: i. to describe proportion of vespa-induced complications. ii. to describe and compare proportion of bronchoscopy-induced complications in vespa and control arms. outline: patients are randomized to 1 of 2 groups. group i: patients receive anesthesia using a standard short breathing tube called laryngeal mask airway (lma) and then undergo standard of care bronchoscopy. group ii: patients receive anesthesia using a longer breathing tube called an endotracheal tube and then undergo standard of care bronchoscopy.

Eligibility criteria:
inclusion criteria: * adult patients undergoing bronchoscopy with radial probe endobronchial ultrasound (rp-ebus) for peripheral lung lesions * recent (\< 4 weeks) chest computed tomography (ct) performed prior to the bronchoscopy * voluntary informed consent to participate in the study exclusion criteria: * patients with baseline lung consolidation, interstitial changes or lung masses (\> 3 cm in diameter) in dependent areas of the lung (right/left \[r/l\] b6, 9, or 10 bronchial segments) as seen on most recent ct * pregnancy * ascites * known diaphragmatic paralysis * air-trapping with residual volume \> 150% of predicted * history of primary or secondary spontaneous pneumothorax * lung bullae \> 5 cm