Kornimate/medical-research-clean huggingface dataset:
comparisons between low thoracic and lumbar epidural analgesia on postoperative pain low thoracic v.s. lumbar epidural for post-cesarean pain

Conditions: Post-cesarean Pain Control Quality

Summary: whether low thoracic epidural analgesia improves postoperative cesarean pain qualities than conventional lumbar epidural analgesia?

postoperative pain remains the leading cause of concern in women faced with undergoing a cesarean delivery. inadequate acute pain management is associated with numerous negative effects, including delayed postpartum recovery, interference with mother-child bonding because postoperative pain limits breastfeeding, and a high risk of postpartum depression and persistent pain. epidural analgesia (ea) is being increasingly preferred to systemic opioid because of better analgesic effect. although ea is widely used for cesarean delivery, the effect of the site of epidural catheter insertion on the quality of postoperative pain management remains inadequately investigated. for example, placement of the epidural catheter in the low thoracic intervertebral spaces may be more suitable for catheter-incision-congruent analgesia during caesarean delivery than in the lumbar intervertebral space; however, epidural catheter insertion is conventionally recommended at the lumbar intervertebral space. therefore, in this study, we aim to investigate the difference in post-cesarean pain control quality between low thoracic ea and lumbar ea.

Eligibility criteria:
inclusion: 1. age between 20-yr and 50-yr parturients 2. elective cesarean delivery exclusion: 1. contraindicated to regional anesthesia, eg. coagulopathy (inr\> 1.5; platelet\< 80000...etc) 2. significant co-morbidities, eg. preeclamspia, heart failure with new york heart association (nyha) classification\> class 2 3. allergy to opioids or local anesthetics

Keywords: patient controlled epidural analgesia ,cesarean delivery,pain management,epidural opioid
real world observational study of sotatercept for pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: the purpose of this study seeks to describe the real world initial experience with sotatercept in the treatment of pulmonary hypertension.


Eligibility criteria:
inclusion criteria: * adults age 18 or greater who are being treated with sotatercept in the mayo pulmonary hypertension clinic. exclusion criteria: * adults lacking capacity to consent
rct of air insufflation versus water infusion colonoscopy by supervised trainees

Conditions: Colorectal Cancer

Summary: our aim is to perform a randomized-controlled trial comparing air insufflation sedated colonoscopy (conventional method) vs. water infusion sedated colonoscopy (study method) by supervised trainees. randomized trials demonstrating reduced need for sedation medications without compromising patients' comfort, cecal intubation rates or polyps detection may cause a paradigm shift and positively alter the way traditional colonoscopy is performed and future endoscopists are trained.

background: a novel water method permitted 52% of patients accepting on-demand sedation to complete colonoscopy without medications and significantly increased successful cecal intubation from 76% to 97% in patients accepting scheduled unsedated colonoscopy. aim: to perform a randomized controlled trial comparing air insufflation (conventional method) vs. water infusion in lieu of air (study method) colonoscopy in minimally sedated patients by supervised trainees. hypothesis: compared with the conventional method, patients examined by the study method have lower pain scores and require less medication but have similar cecal intubation rate and willingness to repeat future colonoscopy. setting: outpatient colonoscopy in a single va hospital methods: after informed consent and standard bowel preparation, patients received pre-medications administered as 0.5 increment of fentanyl (25 μg) and 0.5 increment of versed (1 mg) plus 50 mg diphenhydramine. the conventional and the study method for colonoscopy were implemented as previously described. additional pain medications were administered at the patients' request. outcome measures: increments of medications, pain scores, cecal intubation and willingness to repeat colonoscopy. limitations: single va site, older male population

Eligibility criteria:
inclusion criteria: * adult (\> 50 years old) male and female patients who are scheduled and consented for screening or surveillance colonoscopy, * accept randomization to the study or the conventional method, and agree to complete study questionnaires * the adults will be normal healthy patients or patients with mild systemic disease, asa 1 or asa 2 exclusion criteria: * patients who have contraindications for sedation, decline to participate, unable to give informed consent or complete the questionnaires due to language or other difficulties will be excluded * excluded patients will be managed by usual procedures

Keywords: colorectal cancer screening optical colonoscopy water method sedation
study on hypoallergenic hair dye

Conditions: Contact Dermatitis; Allergy; Dermatitis; Dermatitis

Summary: permanent hair dyes are commonly used in over the counter direct to consumer products and within hair salons. allergy, also known as contact dermatitis, to hair dye is a well known phenomenon. herein, we seek to decrease the risks of allergy to hair dyes by testing a novel version of p-phenylenediamine (ppd) with less allergy potential.

for patients with ppd sensitizations, it is important to find alternatives for dark hair dyes. p-toluenediamine (ptd) and potentially also 2-methoxyethyl p-phenylenediamine (me-ppd) show cross-reactivity with ppd and therefore we want to prove that our new compounds ppd-6 and ppd-7 show no or significantly reduced cross-reactions with ppd and do not induce relevant allergic reactions in patients with proven ppd sensitizations. our specific aims for this study are the following: a1) to show that ppd 6 and ppd 7 have reduced or optimally no reaction in standard patch tests in patients with proven allergy to ppd a2) to compare the sensitization pattern to other possible commercially available alternatives for hair dye, such as me-ppd and ptd a3) to evaluate and rule out any possible non-specific irritant reaction of ppd-6 and ppd-7 in these patch tests (i.e. confirm in-vitro safety profile in-vivo)

Eligibility criteria:
inclusion criteria: - proven diagnosis of ppd and/or ptd sensitization (patch tests and clinically relevant eczematous reactions to hair dye) exclusion criteria: * use of oral immunosuppressive, anti-inflammatory and chemotherapy medications, particularly corticosteroids for at least 1 month before testing. * immunocompromised patient (e.g. cancer, diabetes mellitus, medication, immunodeficiency, radiation therapy) * history of acute hepatitis, chronic liver disease or end stage liver disease. * history of human immunodeficiency virus (hiv) or acquired immune deficiency syndrome. * use of illicit drugs within the past 6 months prior to study start and/or opioid use disorder. * pregnancy as established by questionnaire
prophylactic central lymph node dissection in papillary thyroid microcarcinoma

Conditions: Thyroid Cancer

Summary: the purpose of this study is to determine whether the prophylactic ipsilateral central lymph node dissection is equally effective in the management of papillary thyroid microcarcinoma(ptmc) to the bilateral central lymph node dissection.

the extent, the advantage and disadvantage of prophylactic central lymph node dissection was not fully established up to now in papillary thyroid microcarcinoma. prophylactic bilateral central lymph node dissection can give a important clinical information about the status of lymph nodes, and possibly guide a further adjuvant treatment. however, it causes high postoperative morbidity, including hypocalcemia and hoarseness. in this respect, some advocate no central lymph node dissection in prophylactic settings. thus, we aimed to prove the efficacy of prophylactic ipsilateral central lymph node dissection in thyroid papillary microcarcinoma, compared to the bilateral dissection and no dissection. type of study design: prospective randomized, controlled double-blinded (to subjects and observers) study. group i: limited/ipsilateral central lymph node dissection (unicnd) group ii: comprehensive/bilateral central lymph node dissection (bicnd) group iii: no central lymph node dissection (nocnd) outcomes: vocal cord palsy, hypocalcemia, locoregional recurrence, distant metastasis

Eligibility criteria:
inclusion criteria: * age: 18 to 70 * sonographically node-negative cytology confirmed thyroid papillary carcinoma * tumor size less than 1 cm in sonography * tumor confined to the one lobe of the thyroid gland * one who provides the informed consent exclusion criteria: * history of radiation treatment to head and neck area * history of other malignancy except thyroid cancer * poor performance status (ecog 3-4)

Keywords: papillary thyroid carcinoma lymph node dissection lymph node metastasis prophylactic node dissection central lymph node metastasis
efficacy of traumatic memory modification using memory reconsolidation and propranolol among adolescents with ptsd

Conditions: Post Traumatic Stress Disorder

Summary: the aim of this study is to demonstrate the effectiveness of propranolol in blocking reconsolidation by reducing ptsd symptoms in the short and long term in adolescents with ptsd for more than 3 months.


Eligibility criteria:
inclusion criteria: * - adolescents aged 12 to 18 years; * exposed to a single traumatic event or to events circumscribed in time, including sexual abuse in the absence of reminders in the environment; * fluent in french; * positive diagnosis of ptsd with the scid-5; * disorders evolving for at least three months; * heart rate ≥ 55 bpm; * systolic blood pressure ≥ 100 mmhg; * written parental or legal guardian consent; * written agreement by the adolescent; * adolescents affiliated, via their parents, to the french social security body. exclusion criteria: * - medical condition contraindicating administration of propranolol (copd, asthma, cardio-vascular insufficiency, heart failure as second- and third-degree atrioventricular blocks, prinzmetal angor, pheochromocytoma, raynaud disease, history of an anaphylactic reaction, sinus node disease, hypoglycemia, av blocks) * known chronic renal or hepatic insufficiency * schizophrenia; * mental retardation; * autism spectrum disorder; * acute severe suicidal ideation * traumatic brain injury (loss of consciousness \> 10 minutes); * currently treated for substance or alcohol dependence; * currently treated for attention deficit hyperactivity disorder; * currently treated with a drug that can interfere with propranolol and that can represent a danger according to medical advice if it's suspended more than 24 hours. * currently treated with a bradycardic drug; * concurrent psychotropic medication with the exception of cyamemazine (suspended 48 hours before session) * concurrent trauma-focused psychotherapy in progress or stopped less than 1 month ago; * pregnancy or breast feeding. * current use of "recreative" toxic drugs * concurrent participation to another interventional study
intramuscular ketorolac versus oral ibuprofen for pain relief in first trimester suction curettage

Conditions: Pain

Summary: the aim of this study is to compare the effect of pre-procedural ketorolac to ibuprofen on immediate post-procedural pain scores in patients undergoing first trimester suction curettage with local anesthesia only. our primary hypothesis is that im ketorolac compared to oral ibuprofen will result in an approximate 30% reduction in pain scores on a 21-point numerical rating scale immediately after the procedure. secondary hypotheses include: * pain scores on the 21-point scale will also be significantly lower in the ketorolac group immediately after cervical dilation and 15 minutes post-procedure. * fewer patients in the ketorolac group will rate their pain as "severe" on a subjective pain rating scale. * patients in the ketorolac group will be more satisfied with their pain control. * side effects will be similar between groups.


Eligibility criteria:
inclusion criteria: * women age 18 or older seeking suction curettage at planned parenthood league of massachusetts (pplm) * gestational age less than or equal to 11+6, confirmed by ultrasound * eligible for suction curettage according to pplm protocols * choice of local anesthesia exclusion criteria: * choice of iv sedation for pain control * hypersensitivity to nsaids or lidocaine * contraindications to nsaids: active renal disease active hepatic disease gastric ulcer disease or gastritis long-term nsaid or aspirin use bleeding disorder * nsaids taken \< 8 hours prior to procedure * need for cervical ripening with either misoprostol or mechanical priming agent (laminaria/dilapan) * long-term narcotic use * unable or unwilling to complete required study procedures * previous participation in the study

Keywords: pain suction curettage
a study of bms-863233 in patients with advanced and/or metastatic solid tumors

Conditions: Advanced Solid Cancers; Metastatic Cancer

Summary: the purpose of this study is to determine safety, tolerability and maximum tolerated dose of bms-863233 in subjects advanced and/or metastatic solid tumors.


Eligibility criteria:
phase 1 inclusion criteria: * subjects with advanced and/or metastatic solid tumors who are either refractory to or have relapsed from standard therapies, or for whom a standard therapy does not exist. * ecog performance status ≤ 2 * accessible for treatment, pk sample collection and required study follow-up * total bilirubin ≤ 1.5 x uln and alt, ast ≤ 2.5 x uln exclusion criteria: * women who are pregnant or breastfeeding * subjects with known or suspected brain metastasis, primary brain tumors, or brain as the only site of disease * exposure to any investigational agent within 4 weeks of study drug administration * subjects a history of gastrointestinal disease

Keywords: advanced and/or metastatic solid cancers
a study of teduglutide in japanese people with short bowel syndrome

Conditions: Short Bowel Syndrome

Summary: the main aims of this study are to check for side effects from treatment with teduglutide (revestive) and how well teduglutide controls symptoms of short bowel syndrome. the study sponsor will not be involved in how the participants are treated but will provide instructions on how the clinics will record what happens during the study. during the study, participants with short bowel syndrome will receive an injection of teduglutide just under the skin (subcutaneous) according to their clinic's standard practice. the study doctors will check for side effects from teduglutide for 36 months.


Eligibility criteria:
inclusion criteria: * all participants in japan who received teduglutide will be enrolled in this post marketing surveillance. exclusion criteria: * none
vebreltinib plus plb1004 versus platinum-based doublet chemotherapy in patients with egfrm, met+, locally advanced or metastatic nsclc following egfr-tki failure

Conditions: Non-Small-Cell Lung Cancer

Summary: efficacy and safety of vebreltinib in combination with plb1004 versus platinum-based doublet chemotherapy in patients with egfr mutations, met amplification and/or overexpression, locally advanced or metastatic non-small cell lung cancer following egfr-tki treatment failure

a randomized, controlled, open label, multicenter phase iii study to evaluate the efficacy and safety of vebreltinib in combination with plb1004 versus platinum-based doublet chemotherapy in patients with egfr mutations, met amplification and/or overexpression, locally advanced or metastatic non-small cell lung cancer following egfr-tki treatment failure

Eligibility criteria:
inclusion criteria: 1. ability to understand and willingness to sign a written informed consent document. 2. aged at least 18 years old. 3. histologically or cytologically confirmed locally advanced or metastatic nsclc (stage iiib\~iv). 4. at least one measurable lesion as defined by recist v1.1. 5. ecog performance status 0 to 1. exclusion criteria: 1. there are mutations of alk or ros1. 2. have symptomatic and neurologically unstable central nervous system (cns) metastases or cns disease that requires increased steroid doses for control. 3. before randomization, patients did not recover from any toxicity and/ or complications of previous chemotherapy, surgery, radiotherapy and other anti-cancer treatments, that is, did not fall to grade 1 or lower (national cancer research common toxicity criteria for adverse events \[nci-ctcae\] v5.0), except for hair loss and irrecoverable permanent radiation damage. 4. major surgery or had significant traumatic injury within 4 weeks prior to the first dose of the investigational product. 5. pregnant or nursing women.

Keywords: nsclc lung cancer met amplification egfr l858r egfr exon 19 deletion egfr
physiotherapy in exacerbation chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is a chronic condition. its evolution can be aggravated in some periods by an increase of the symptoms (above all the cough, the dyspnoea and the quantity of sputum purulence). this is known as exacerbation and it is the most frequent cause of hospital stay, urgences services and death in copd. a physiotherapy program is carrying out in patients attending to the hospital because of an exacerbation. the hypothesis of this study is that a physiotherapy program added to a medical treatment increase the ventilatory function, the physiques variables, decrease depression and anxiety and improve the quality of life. additionally, it is going to be assessed the effect of physiotherapy in time using phone calls and visits to the patient's home.

the benefits added to the respiratory physiotherapy and physical activity have been evidenced previously in the treatment of copd. this justify the need of a short physiotherapy intervention program regarding to the hospital stay in exacerbation of copd and a follow-up after the hospital stay. 4% of europeans have been reported to have medical intervention caused by respiratory exacerbation. 20% of these patients are patients with copd. the mortality of copd exacerbation is about 14% and 30% if mechanical ventilation is needed. in order to that, it is very important to improve the quality of life and the recuperation of patients. it is relevant to mention the the high cost associated to this condition.

Eligibility criteria:
inclusion criteria: * copd diagnosis with exacerbation. * no contraindication of physiotherapy. * signed written consent. * medical approval for inclusion. exclusion criteria: * heart disease. * neurological patients. * contraindications of physiotherapy.

Keywords: copd, physiotherapy, exacerbation
a lead-in study evaluating efficacy of guesswhat mobile app therapy for children with autism

Conditions: Autism; Autism Spectrum Disorder

Summary: the following study aims to assess the efficacy, safety data, and best outcome measurements of the mobile game platform, guesswhat, in delivering behavioral therapy to children with autism spectrum disorder (asd). guesswhat is a mobile application (available for free for ios and android) which contains a suite of games: pro-social charades, emotion guessing, and quiz. participant families will use their personal smartphones to download the app and play it with their child according to a predetermined regimen.

the following study aims to understand the efficacy and safety of the mobile game platform, guesswhat, in delivering behavioral therapy to children with autism spectrum disorder (asd). guesswhat is a mobile application (available for free for ios and android) which contains a suite of games: pro-social charades, emotion guessing, and quiz. participant families will use their personal smartphones to download the app and play it with their child according to a predetermined regimen. the study will enroll parents who are at least 18 years old and have a child between 3 and 12 years old with a formal asd diagnosis. parents will be asked to complete two clinical outcome measure questionnaires immediately prior to and up to 1 week after playing guesswhat with their child 3 times per week for 4 weeks.

Eligibility criteria:
inclusion criteria: 1. parent who is at least 18 years old of child with autism. 2. child with autism is between 3 and 12 years old at time of baseline data collection. exclusion criteria: 1. parent is unable to read english. 2. parent does not have an android or ios smartphone compatible with guesswhat app--the app will be available on android after further development and we will notify interested families when it becomes available.

Keywords: digital health mhealth autism intervention behavioral therapy
trimetazidine in myocardial injury after percutaneous coronary intervention in patients with angina and diabetes

Conditions: Diabetes Mellitus; Angina, Unstable

Summary: introduction: recent studies have suggested that trimetazidine may help reduce myocardial damage following percutaneous coronary intervention. however, the evaluation of the potential of this medication in the reduction of myocardial damage in patients with diabetes mellitus and unstable angina, in a prospective and randomized way, has not yet been described. objective: the aim of this study was to evaluate the efficacy and safety of the use of trimetazidine versus placebo in patients with diabetes mellitus and unstable angina undergoing coronary stent angioplasty. methodology: for this, a unicentric, randomized, double blind and prospective study will be performed in a comparative manner. hospital data (test results, medical outcomes, drug dose, complications) of patients will be analyzed for safety and effectiveness. myocardial damage will be measured by means of ultrasensitive troponin dosages. expected results: the use of trimetazidine reduces myocardial damage in patients with diabetes mellitus and unstable angina undergoing coronary stent angioplasty.


Eligibility criteria:
inclusion criteria: * adult men and women aged\> 18 years. * diagnosis of unstable angina with chest pain at least 2 hours after arrival at the emergency unit. * measurement of troponin less than the upper limit of the normality of the method. * indication of cardiac catheterization and need for percutaneous coronary intervention with uniarterial stent within 24 hours of admission. * no known allergy to trimetazidine. * prior diagnosis of diabetes mellitus under specific treatment. * clcr\> 30 ml / min. * signed consent form. exclusion criteria: * pregnancy. * hemodynamic instability (pulmonary congestion / systolic blood pressure less than 90 mmhg). * sca with st elevation or troponin elevation. * body mass index greater than 40 kg / m2. * use of oral anticoagulant. * orotracheal intubation. * left ventricular outflow tract obstruction. * allergy to iodinated contrast. * thoracic trauma in the last 30 days. * previous surgical myocardial revascularization. * presence of ventricular arrhythmias.