Kornimate/medical-research-clean huggingface dataset:
clinical performance of 59% hioxifilcon a vs. marketed hydrogel contact lenses in habitual hydrogel wearers

Conditions: Refractive Error - Myopia Bilateral

Summary: the study will compare the short-term clinical performance and wearer and practitioner acceptability of a new-to-market spherical daily disposable (dd) hydrogel soft contact lens to a currently marketed spherical dd hydrogel soft contact lens.

this randomized clinical trial will compare the short-term clinical performance, and wearer acceptability of a new-to-market hioxifilcon a spherical daily dd contact lenses against marketed dd lenses in a short cross-over clinical trial. the primary outcome variable for this study is overall subjective comfort.

Eligibility criteria:
inclusion criteria: * currently wearing hydrogel, spherical dd contact lenses at least 5 days/week * vision correctable to 20/30 acuity in each eye with spherical dd contact lenses * no ocular or systemic disease that contra-indicates soft contact lens wear exclusion criteria: * currently wearing silicone hydrogel dd contact lenses * currently wearing 1-day acuvue® moist (comparator) contact lenses * currently using rewetting drops with habitual contact lenses * vision not correctable to 20/30 * participating in another clinical trial
comparison of a pain pump versus injectable medication for analgesia in knee arthroscopy

Conditions: Pain

Summary: hypothesis: ropivacaine, morphine and ketorolac injected after knee arthroscopy is as effective as this solution plus ropivacaine administered intra-articularly for twenty-four hours. three groups were assigned random patients, each group provided a different method of pain medication in order to determine the effectiveness of each treatment.

arthroscopic knee patients were randomized to 1 of 3 groups. a) 30ml of ropivacaine (0.5%), 30mg of ketorolac and 8mg of morphine sulfate injected plus a pain pump containing 100ml of ropivacaine (0.5%) administered at 4 ml/hour; b) an identical solution plus a pain pump containing 100-ml of normal saline administered at 4 ml/hour; c) an identical solution and no pain pump. pain level, the amount of pain medication used and time to discharge were recorded. clinical and radiographic evaluation was performed at nine months after surgery.

Eligibility criteria:
inclusion criteria: all subjects who underwent: * knee arthroscopy + synovectomy * knee arthroscopy + partial or complete meniscectomy * knee arthroscopy + chondroplasty * knee arthroscopy + microfracture * knee arthroscopy + autologous osteoarticular transplantation exclusion criteria: * a surgical procedure that required an incision other then an arthroscopic portal * a surgical procedure within the same joint within ninety days * a acute or chronic knee infection * any diagnosis of complex regional pain syndrome * a known allergy to one of the study drugs * a documented history of narcotic use * a score of less than two standard deviation on the sf-12 mental component * any major systemic or cardiac illness (heart failure, uncontrolled angina, bifascicular blocks, renal insufficiency, or liver disease) * under the age of eighteen years
validation of the spanish version of the neck disability index

Conditions: Neck Pain; Cervicalgia

Summary: the primary purpose of this study is to adapt the neck disability index (ndi)and the cervical core set 6 (ccs6) to the spanish population. other objectives are to determine the correlation between intensity of cervical pain, degree of disability, and quality of life; to determine the correlation between the ndi, ccs6 and the northwick park neck pain questionnaire; and to determine factors that predict the chronification of disability.


Eligibility criteria:
inclusion criteria: * patients who visit physician for cervicalgia * with or without referred pain * must be able to read and write exclusion criteria: * disease of central nervous system, with or without treatment * migraine * indications for surgery * suspicion of systemic disease

Keywords: neck pain cervicalgia quality of life disability
corneal collagen crosslinking with riboflavin for keratoconus treatment: a brazilian study

Conditions: Keratoconus

Summary: cross-linking of the cornea increases the mechanical and biochemical stability of the stromal tissue. the purpose of this study is to assess the effectiveness of riboflavin-ultraviolet light induced cross-linking of corneal collagen in improving visual acuity and reducing progression of keratoconus in the brazilian population.


Eligibility criteria:
inclusion criteria: * age from 18 to 35 years. * diagnosis of keratoconus. * progression of ametropia. * written informed consent. exclusion criteria: * corneal thickness \< 395 micra at thinnest point. * other active ocular disease than keratectasia. * cornea guttata. * previous ocular surgery. * pregnancy. * known sensitivity to riboflavin.

Keywords: keratoconus
eyecontrol communication platform for delirium management in intensive care units (emerge)

Conditions: Delirium; Delirium in Old Age; Critical Illness; Intensive Care Unit Delirium

Summary: the purpose of this research is to investigate whether addition of the eyecontrol-pro platform as an adjunct to standard guideline-based intensive care unit management of critically ill patients is effective in reducing delirium incidence and severity.

this is a prospective, binational, single-blind, multicenter, randomized control trial, conducted according to international good clinical practice (gcp) ethical and quality standards. critically ill, mechanically ventilated patients aged \>=50 years with richmond agitation sedation scale (rass) score of -3 to +1 (at time of screening) who are anticipated to require ventilation for \>=24 hours will be eligible for recruitment. the study will be conducted simultaneously at beth israel deaconess medical center (bidmc) boston, usa, assuta ashdod medical center (ashdod, israel) and rabin medical center (petah tikvah, israel) with bidmc contributing up to 50% of the total enrollment. participants will be randomized to either a) sham device or b) active intervention arm (details described below). legally appointed representatives, patients and caregiver teams will be administered an optional questionnaire to assess their experience with the study device at the conclusion of the study protocol. study subjects will be administered the telephone-montreal cognitive assessment (t-moca); total score of 22 - missing 8 points present in montreal cognitive assessment (moca) pertaining to drawing/executive function not feasible over phone) or moca (if still in-hospital; assessed out of total score of 30) and hospital anxiety and depression scale (hads) questionnaire 30 days post-randomization. hebrew versions of these questionnaires will be used at israeli sites.

Eligibility criteria:
inclusion criteria: * mechanically ventilated patients aged \>=50 years * rass score of -3 to +1 and * anticipated to require \>=24 hours of mechanical ventilation exclusion criteria: * not expected to survive \>=24 hours * have limitations in care (do not resuscitate, or comfort-focused care orders) * receiving paralytic neuromuscular blocking agent (nmba) infusion or anticipated need for nmba use * have advanced dementia or cognitive impairment including post-concussive syndrome. * have acute or subacute neurological disorders. * have severe uncorrected psychiatric disorders. * have uncorrected hearing or visual impairment. * acute or subacute neurological disorder hindering communication or ability to participate in cam icu assessments * enrolled in a clinical trial which prohibits co-enrollment. * incarcerated * have no identified legally appointed representative (lar) * are unable to communicate in the predominant local language (english at us site and english/hebrew/arabic/russian in israel) * refusal of treating clinical team.
3dv+tps applied to radiotherapy for nasopharyngeal carcinoma

Conditions: Nasopharynx Cancer; Radiotherapy

Summary: verify that 3dv+tps is non-inferior compared to existing imported tps and superior to existing domestic tps.

the main purpose of the study was to verify that 3dv+tps is non-inferior compared to existing imported tps and superior to existing domestic tps. a total of 100 patients were enrolled. the primary endpoint of the study was the objective response rate (orr), and the secondary endpoint was the local control rate and the incidence of treatment-related side effects.

Eligibility criteria:
inclusion criteria: 1. consolidate other serious diseases that affect quality of life or treatment; 2. reluctant to actively cooperate with the investigator; 3. mergers with distant transfers; 4. patients who have undergone head and neck surgery and radiotherapy; 5. subjects who are affected by the disease who sign a written informed consent or follow the study procedure; or who are unwilling or unable to comply with the research requirements. 6. those who have a history of psychotropic substance abuse who are unable to quit or have a mental disorder; 7. participated in other clinical trials of anti-tumor drugs within 4 weeks before enrollment; 8. pregnant or lactating women; 9. the investigator judges other conditions that may affect the clinical study and the outcome of the study. exclusion criteria: 1. those who did not follow the protocol. 2. the subject is aggravated or has a serious adverse reaction. 3. the subject himself requested to withdraw from the trial. 4. the patient is lost to follow-up or died. 5. the researcher believes that there is reason to withdraw

Keywords: nasopharynx cancer radiotherapy
a multifactorial exercise program to reduce falls in people with parkinson disease

Conditions: Parkinson Disease

Summary: the primary objective of this study is to investigate the effects of a theoretically driven, highly challenging exercise program (balance and strengthening exercises) in reducing fall rate, improving balance and reducing fear of falling in persons with parkinson's disease. in this pilot, randomized, cross-over study, 32 participants with parkinson disease will be randomly assigned to either an early start (immediately following enrollment) or late start (3 months after enrollment) multifactorial exercise program which will meet 2 times per week for 1.5 hours over 3 months. the exercise program will consist of balance and strengthening exercises which will be individualized depending on the ability of each participant. fall rate, balance, walking ability, fear of falling, mood, anxiety, and quality of life will be measured prior to the start, at 3 months and 6 months after enrollment. subjects will be enrolled for 6-7 months.


Eligibility criteria:
inclusion criteria: * have a diagnosis of idiopathic parkinson's disease (using uk brain bank criteria) * have a hoehn \& yahr stage of 2-4 during the "on" state * mini mental status score \> 26 * be 40 years of age or older, so as to represent the typical age range of pd * be on a stable dose of parkinson's medications for at least 2 weeks prior to study onset and during the 3 month study period. * have experienced at least one fall in the past 3 months and greater or equal to 2 falls in the past one-year (a fall was defined as an unexpected event where the person inadvertently came to rest on the ground or other lower level not due to a major intrinsic or extrinsic event) * able to walk without physical assistance or an assistive device for at least 5 continuous minutes * able to understand, communicate with and be understood by recruitment personnel * able to attend the exercise program twice per week at sargent college * be interested in participating and provide informed consent exclusion criteria: * have a diagnosis of atypical parkinsonism * have a hoehn \& yahr stage of 1 or 5 * have had previous surgical management of pd (i.e., deep brain stimulation surgery; pallidotomy) * serious co-morbidities that may interfere with ability to participate in an exercise program (i.e., musculoskeletal, cardiovascular, and neurological (other than parkinson's)) * be pregnant

Keywords: postural instability (falling) gait disturbances (e.g., freezing) bradykinesia (slowness of movement), rigidity
octreotide improves human lymphatic fluid transport a translational trial

Conditions: Lymphatic Diseases; Chylothorax

Summary: this study aims to investigate whether octreotide, a medication used off-label to treat chylothorax, has a direct effect on human lymphatic drainage. to study the effects of octreotide, the researchers conducted a pre-clinical experiment using human lymphatic vessels mounted in a myograph chamber and a clinical experiment in which a double-blinded, randomized, cross-over trial was conducted in 16 healthy adults. the results of the study will be used to determine the role of octreotide in the treatment of chylothorax and other lymphatic disorders.

this study aimed to investigate whether octreotide, a medication used off-label to treat chylothorax, has a direct effect on human lymphatic drainage. chylothorax is a condition in which there is an accumulation of lymphatic fluid in the chest cavity, and the mechanism through which octreotide helps to resolve this condition is not well understood. it has been speculated that the drug may reduce lymph production, but this has not been directly demonstrated. to study the effects of octreotide on human lymphatic vessels, the investigators conducted two experiments: a pre-clinical experiment using human lymphatic vessels mounted in a myograph chamber, and a clinical experiment in which a double-blinded, randomized, cross-over trial was conducted in 16 healthy adults, assessed by using plethysmography and near-infrared fluorescence imaging. the results of the study will be used to determine the role of octreotide in the treatment of chylothorax and to clarify the mechanism through which it acts. it is important to continue researching and developing effective treatments for chylothorax, as it can be a difficult condition to manage and may cause serious complications if left untreated.

Eligibility criteria:
inclusion criteria: \* healthy exclusion criteria: * no daily medication (except birth control), or allergies towards contrast agents.
dexamethasone added in ultrasound-guided transversus abdominis plain block for postoperative analgesia

Conditions: Postoperative Pain

Summary: dexamethasone added to levobupivacaine in ultrasound-guided tranversus abdominis plain block increased the duration of postoperative analgesia after laparoscopic cholecystectomy.

in the ultrasound-guided tap-block with dexamethasone group, dexamethasone is added to levobupivacaine in ultrasound-guided tranversus abdominis plain block after laparoscopic cholecystectomy. in the ultrasound-guided tap-block with saline group, saline is added to levobupivacaine in ultrasound-guided tranversus abdominis plain block , after laparoscopic cholecystectomy. in the ultrasound-guided tap-block with intravenously dexamethasone group, dexamethasone is intravenously injected , after laparoscopic cholecystectomy. after surgery the extension of postoperative analgesia, incident and rest pain were evaluate in each group.

Eligibility criteria:
inclusion criteria: * patients with asa score i and ii * age 18 years exclusion criteria: * allergy to local anesthetics * allergy to general anesthetics * allergy or intolerance to acetaminophen * severe renal impairment * severe hepatic impairment * congestive heart failure * coagulation disorders * hypoprotidemia * diabetes mellitus history * age greater than 70 years * age below 18 years * asa physical than 3 status * lack of informed consent * patients unable to discernment * intolerance to opiates * peptic ulcer * abuse of alcohol and / or drugs

Keywords: analgesia dexamethasone levobupivacaine ultrasound-guided tranversus abdominis
comparıson of peng block wıth intra-articular and quadratus lumborum block i̇n primary total hip arthroplasty

Conditions: Hip Arthropathy

Summary: 90 patients asa i-iii, undergoing total hip arthroplasty (tha) under spinal anesthesia, will be randomly assigned into one of three groups, namely group a (n=30), where an peng block, group b (n:30) where an inra-articuler, and group c (n=30) where quadratus lumborum block will be performed preoperatively. all patients will receive a standardized postoperative analgesia regimen. nrs scores will be evaluated in static and dynamic conditions during the first 48 hours postoperatively.

total hip arthroplasty (tha) is the second most common joint replacement surgery, partly due to the aging population. the primary aim of this study is to compare the analgesic efficacy of pericapsular nerve group (peng) block with intra-articular and quadrotus lumborum block (qlb). regional anesthesia (ra), such as the recently described pericapsular nerve group (peng) block, may provide additional analgesic benefit in this situation. pericapsular nerve group (peng) block is a new regional anesthesia technique to provide analgesia after hip fractures and hip arthroplasty. the aim of this single-center, double-blind, randomized controlled trial is to confirm the efficacy of peng block for postoperative recovery after primary tha. routine multimodal analgesia will be used for postoperative analgesia

Eligibility criteria:
inclusion criteria: * physical status according to american society of anesthesiologists (asa ) i-iii exclusion criteria: * previous operation on the same hip * hepatic or renal insufficiency * younger than 18 years old and older than 85 * patients undergoing general anesthesia * allergy or intolerance to one of the study medications * bmi \>40 * asa iv * chronic gabapentin/pregabalin use ( regular use for longer than 3 months) * chronic opioid use ( taking opioids for longer than 3 months, or daily oral morphine equivalent of \>5 mg/day one month

Keywords: peng block intra-artikuler quadrotus lumborum block hip arthropathy
partner assistance in learning and performing skin self-examination

Conditions: Melanoma

Summary: this study is a behavioral science study designed to identify aspects of the dyadic relationship that promote skin self-examination (sse) in patients at high risk of developing melanoma. the patient is randomized to receive the educational intervention either as a solo learner or with the partner.


Eligibility criteria:
inclusion criteria: * personal or family history of melanoma. if a personal history of melanoma, the patient was treated at least 1 month ago * evidence of dysplastic nevus syndrome or a large number of moles (greater than 50) * able to see to read a newspaper, can read at an eighth grade level * speaks english * 18 to 70 years old with a spouse or cohabitating partner exclusion criteria: * under 18 years of age * patient overburden by other co-morbid diseases such as chronic immunosuppression from organ transplantation * have insufficient vision to to read a newspaper * unable to read english * have insufficient cognitive skills to follow instructions provided at an eighth grade language level

Keywords: skin self-examination sse melanoma
morphofunctional imaging and developmental dyslexia

Conditions: Developmental Dyslexia

Summary: developmental dyslexia is a frequent learning disability. the aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. they are compared to control adults paired with age and laterality. to study phonological treatment, the researchers used functional magnetic resonance imaging (fmri) with a rime judgement task and silent word generation.


Eligibility criteria:
inclusion criteria: * developmental dyslexia according to critchley. * normal performance intelligence quotient (piq) * age: 18-35 years * sex: male * right handed * no hearing deficit. exclusion criteria: * no head injury * no attention deficit hyperactivity disorder (adhd)

Keywords: phonological treatment language fmri
effects of postoperative pain management on immune function after laparoscopic resection of colorectal cancer

Conditions: Colorectal Surgery

Summary: the purpose of this study is to compare postoperative immune function (e.g. nk cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery


Eligibility criteria:
inclusion criteria: * asa class i-iii * 20-80 years old * elective laparoscopic colorectal surgery for cancer exclusion criteria: * drug allergy * significant renal or hepatic impairment * sign of infection

Keywords: analgesia; colorectal surgery; immunity; local anesthetics; opioids
impact of local anesthetic wound infiltration on postoperative pain following cesarean delivery

Conditions: Pain

Summary: the purpose of this study is to determine if the infusion of the local anesthetic ropivacaine (a numbing medicine) and the non-steroidal anti-inflammatory drug ketorolac (a pain killer similar to ibuprofen) through a catheter placed along the cesarean delivery incision, will reduce the pain experienced after cesarean section and need for narcotic pain medicine.


Eligibility criteria:
inclusion criteria: * american society of anesthesiology (asa) class 1,2, and 3 * english speaking women at a gestational age \> 37 weeks * scheduled for cesarean delivery under spinal or combined spinal epidural anesthesia exclusion criteria: * bmi \> 50 kg/m2 * history of intravenous drug or opioid abuse * previous history of chronic pain syndrome * history of opioid use in the past week * allergy or contraindication to any of the study medications * non-english speaking

Keywords: cesarean section