Kornimate/medical-research-clean huggingface dataset:
cognitive enhancement on working memory in patients with schizophrenia

Conditions: Memory Deficits; Schizophrenia; Neurostimulator; Complications

Summary: the investigators plan to investigate the effect of enhancement on working memory (wm) in patients of chronic schizophrenia and determine the predictive factors of effective treatment.

schizophrenia is a chronic and disabling disease with a prevalence of 0.5%\~1.5% in the general population. it's estimated 98% of patients with schizophrenia exhibit variable degrees of cognitive deficits which have been well established to be predictive of patient functioning. a number of treatments had been developed for cognitive enhancement in patients with schizophrenia, nevertheless none of them showed satisfying results. transcranial direct current stimulation (tdcs) is a safe and convenient treatment which has showed some evidence of beneficial effects on working memory (wm) in both healthy and neuropsychiatric populations. however, studies of tdcs for cognitive enhancement in patients with schizophrenia are still quiet limited. the results of our previous studies in healthy participants and patients with diabetic polyneuropathy suggest that the anodal tdcs over right dorsolateral prefrontal cortex (dlpfc) improved spatial wm capacity, particularly when task difficulty demands more complex mental manipulations and for the low-performing patients in baseline assessments. thus, we hypothesize that in the baseline the more severe the patients' cognitive deficit are, the greater their wm capacity improvement would be after applying the anodal tdcs over right dlpfc. the investigators plan to recruit 40 patients with chronic schizophrenia. first, the investigators will collect baseline characteristics including disease severity, cognitive deficits and brain connectivity. then the investigators will adopt a sham-active crossover design for tdcs treatment with the order of the two sessions (sham and active) counterbalanced across participants. the investigators will perform pre- tdcs and post- tdcs assessments of their spatial wm and verbal wm as well as statistical analyses to see if the effect of cognitive enhancement reaches a significant level. in addition, the investigators will explore the possible predictive indicators of effective treatment.

Eligibility criteria:
inclusion criteria 1. inform consent acquired 2. age 20 to 50 3. right-handed 4. patients with schizophrenia diagnosed according to dsm-5 criteria exclusion criteria 1. participants who are pregnant or breastfeeding 2. participants who have metal implants 3. participants who have alcohol/substance use disorder or received electro-convulsive therapy within the past 6 months. 4. participants who have history of head injury with loss of consciousness 5. participants who have history of brain lesions, infection, or epilepsy 6. skin lesions on the electrodes placed 7. cancer patients 8. patients with high fever 9. patients with significant sensory loss

Keywords: schizephrenia cognitive enhancement transcranial direct current stimulation non-invasive brain stimulation working memory
risi in the treatment of recurrent chest wall malignancies after ebrt

Conditions: Chest Wall Tumor

Summary: this study will observe the efficacy and toxicities of 3-dimensional printing noncoplanar template assisted ct guided radioactive iodine-125 seeds implantation in the treatment of patients with recurrent chest wall malignancies after external beam radiotherapy prospectively, and analyzes the influence of clinical and dosimetric factors on the outcomes.

radioactive iodine-125 seed brachytherapy is a conventional treatment in peking university third hospital. radioactive iodine-125 seed brachytherapy is the implantation of iodine-125 seed into tumors.the radioactive iodine-125 seed can release low dose of irradiation persistently which kills tumors cell and causes less damage to normal tissue at the same time. this study will enroll the patients with recurrent chest wall malignancies after external beam radiotherapy (primary or metastasis) who underwent ct-guided radioactive iodine-125 seed implantation assisted by 3d-printing template from 2019 to 2021. the investigators evaluate the dose that covers 90% target volume(d90) and other parameters after the implantation. the efficacy and adverse events will be observed. local control(lc) time and overall survival(os) time are evaluated.

Eligibility criteria:
inclusion criteria: * histological proven malignant tumor * tumor located in chest wall and lesion diameter \<= 10 cm * recurrence after external beam radiotherapy * there is no bleeding tendency * there are no serious or uncontrolled underlying diseases (such as severe or uncontrolled hypertension, diabetes, cardiovascular and cerebrovascular diseases, and/or organ dysfunction * there is an appropriate puncture path which is expected to achieve the treatment dose * kps \> 70, which is expected to be able to tolerate puncture/ brachytherapy, and the expected survival time is longer than 3 months exclusion criteria: * there are skin ulceration, or with high risk of skin infection and ulceration * liquefaction and necrosis in a large area in tumor with poor expected seeds distribution * pregnant women, lactating women, psychiatric patients * patients with poor compliance can not complete the treatment * patients that researchers considered inappropriate to participate in this clinical trial

Keywords: radioactive iodine-125 seeds implantation 3d-printing template chest wall malignancies
mobile interventions for the prevention and detection of distress

Conditions: Depression; Anxiety; Stress; Loneliness

Summary: stress, anxiety, distress and depression are exceptionally high among healthcare providers at the frontline of the covid-19 pandemic. knowledge of factors underlying distress and resilience and evidence based interventions to impact the mental wellbeing of frontline healthcare providers is limited. this study will evaluate a novel mobile platform to gather the "distress experience" of healthcare workers at unity health toronto in real time during and after the covid-19 pandemic, use automated personalized mobile interventions (e.g. routine, sleep, exercise) to nudge active/passive parameters to manage distress.


Eligibility criteria:
inclusion criteria: * staff or healthcare providers working at unity health toronto * 18 years of age or older * must own a mobile phone running android version 6.0 and higher, or an iphone 6 running os 14 and higher) exclusion criteria: * non-unity health toronto staff

Keywords: depression anxiety stress loneliness mobile intervention
tibial tunnel placement for acl reconstruction

Conditions: Complete Tear, Knee, Anterior Cruciate Ligament; Rupture of Anterior Cruciate Ligament

Summary: although extensive research has been carried out on anterior cruciate ligament (acl) femoral tunnel placement, very little attention has been given to the tibial tunnel. researchers have suggested that the tibial tunnel be placed in the center of the acl footprint, which they described as being approximately 43% of the way (anterior-to-posterior) across the proximal tibia at its widest extent. however, others have suggested that a more anterior placement may yield improved biomechanical and clinical results. the center of the acl footprint and the posterior aspect of the anterior horn of the lateral meniscus does not yield tibial tunnel placement a consistent percentage of the way across the tibial plateau; therefore, guidelines should be based on intraoperative fluoroscopic measurements. however, the question remaining is what percentage of the anterior-to-posterior distance across the tibia is the ideal location for the tibial tunnel in acl reconstruction. this study will help answer that question. patients with a diagnosed rupture of the acl who are scheduled for surgical reconstruction will be considered for enrollment. eligible patients will be allocated to one of two groups based on the location of the tibial tunnel (anterior vs. posterior) during the surgical procedure. in addition to a baseline (pre-operative) evaluation, participants will return for follow-up visits at 6, 12, and 24 months post-surgery. follow up will be completed at 24 months. the primary objective of this study is to collect subjective and objective measures of knee-related function in patients with an anterior vs. posterior placed tibial tunnel through 24 months postoperative care.


Eligibility criteria:
inclusion criteria: * age at time of randomization: 16 - 50 years (skeletally mature) * primary, uncomplicated acl reconstruction * autograft (stg or bptb) exclusion criteria: * multiple ligament knee injury (full thickness) * revision acl reconstruction * acl reconstruction with allograft * meniscectomy \> 75% * treatable articular cartilage lesions * diagnosis of tibiofemoral or patellofemoral osteoarthritis (kellgren lawrence grade \> ii) * valgus alignment on long-leg cassette (weight bearing line outside of joint center) * prior surgery in the ankles, knees, or hips * clinical evidence of hip disease * patellofemoral joint instability * significant patellar or tibiofemoral mal-alignment * bmi \> 35 * type 1 diabetes mellitus * known connective tissue disorder (e.g. ehlers-danlos) * peripheral neuropathy * neurovascular/ circulatory disorder * any form of inflammatory arthritis (e.g. rheumatoid arthritis, gout, pseudogout, lupus, etc.) * significant co-morbid conditions as determined by the investigator (e.g. malignancy, renal, hepatic disease, etc.) * known or suspected psychological disorder
study of circulating markers in serum of patients treated for metastatic colorectal cancer

Conditions: Metastatic Colorectal Cancer

Summary: the primary purpose of the study is to confirm the results of previous study about the usefulness of the serum carcinoembryonic antigen (cea) kinetic for chemotherapy monitoring in patients with unresectable metastasis of colorectal cancer (j clin oncol 2008;26:3681-6). the secondary purpose is to evaluate the value of circulating free mutant dna and circulating tumor cells (ctc) and their variations during the treatment.

prospective cohort study of patients treated with systemic chemotherapy for unresectable metastatic colorectal cancer. the chemotherapy monitoring is currently based on radiological evaluation (recist criteria) and clinical evaluation. circulating markers as cea, free mutant dna, ctc represent an alternative approach. a previous study on usefulness of the serum carcinoembryonic antigen (cea) kinetic for chemotherapy monitoring in patients with unresectable metastasis of colorectal cancer has been published (j clin oncol 2008;26:3681-6). the present study is designed to validate the previous data. the secondary purpose is to evaluate variations of free mutant dna and ctc during the chemotherapy. patients will be included prospectively in 4 centers in normandy. all systemic chemotherapy and biotherapy validate in this clinical situation by the french national cancer institute (inca) is accepted. evaluation of response based on recist criteria will be performed every 3 months. blood samples for cea and ca 19-9 levels will be performed every courses of chemotherapy during first 3 months. blood samples for detection of free mutant dna and ctc will be performed at day 1 and 42 of chemotherapy.

Eligibility criteria:
inclusion criteria: * patient has stage iv colorectal adenocarcinoma histologically proved * patient has at least one measurable lesion * patient has performance status 0-2 on the who performance scale * patient is male or female, and \> 18 years of age * patient has agree to participate by giving written informed consent exclusion criteria: * patient has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study.

Keywords: metastatic colorectal cancer circulating tumor markers circulating tumor cell circulating tumor dna marker's kinetic
hearing aids and the brain

Conditions: Hearing Loss

Summary: hearing aids are being fit on inexperienced hearing aid users and the short-term and long-term effects are measured. this research aims to improve understanding of the individual factors that contribute to receiving benefit from hearing aids and lead to more individualized treatment of hearing loss.

hearing aids are used to improve audibility for patients with hearing loss and improve speech perception. in addition to these immediate benefits, amplification has the potential to have long-term effects on higher level auditory processing abilities, such as cognition or other abilities required for complex listening tasks. these long-term acclimatization effects are not well understood and merit further behavioral and physiological examination. hearing aids will be fit on inexperienced hearing aid users and outcome measures will be used to determine immediate and long-term effects of hearing aids. this research may provide a more detailed view of individual differences that contribute to receiving benefit from a hearing aid and may lead to more individualized treatment of hearing loss.

Eligibility criteria:
inclusion criteria: * 50 years of age or older * bilateral, mild to moderately severe hearing loss * inexperienced hearing aid users exclusion criteria: * subject deciding that they do not wish to wear hearing aids as necessitated per study protocol * audiometric thresholds that suggest research stimuli would not be audible * conductive hearing loss and/or other significant ear or hearing problems * non-native english speakers * conditions or circumstances that would preclude a participant from wearing hearing aids consistently or finishing the study * an inability to perform or complete the experimental tasks

Keywords: auditory perception hearing
systematic review and meta-analysis of venous thromboembolism (vte) risk assessment in hospitalized medical patients

Conditions: Venous Thromboembolism

Summary: a systematic review and meta analysis will be performed of risk assessment models for venous thromboembolism ("vte" including pulmonary embolism "pe" and deep venous thrombosis "dvt")in hospitalized medical patients. the goal of this study is to evaluate whether the incidence of vte is lower in patients that are evaluated with a risk assessment model and treated with thromboprophylaxis for their assigned level of risk.

venous thromboembolism ("vte" including pulmonary embolism "pe" and deep venous thrombosis "dvt") is associated with significant morbidity and mortality. only about half of eligible hospitalized medical patients receive appropriate thromboprophylaxis. understanding vte risk factors predictive of vte among hospitalized medical patients may promote superior thromboprophylaxis. to date a systematic review of vte risk assessment strategies among hospitalized medical patients, and a meta-analysis reporting the rate of vte among patient groups at varying levels of risk for vte does not exist. the investigators will use the preferred reporting items for systematic reviews and meta-analyses (prisma) checklist for reporting systematic reviews and meta-analyses to develop this systematic review and meta-analysis. the investigators will perform a systematic review of the literature and report vte risk assessment models that have been derived and validated among hospitalized medical patients. the investigators will perform a meta-analysis of studies that report a rate of vte among patients identified as being at elevated risk for vte and those that are not. the investigators pre-specify that they are going to analyze the prospective and retrospective studies captured by the literature search in two ways. first, the investigators will perform an analysis that groups both prospective and retrospective studies together. the investigators will also perform an analysis that separates out the prospective and retrospective studies. while this will decrease our sample size (and thus power), this approach may allow us to identify any bias or confounding present due to the retrospective study design and then control for it. notably confirmation that both retrospective and prospective studies identified the same findings would enhance the clinical usefulness of our findings.

Eligibility criteria:
inclusion criteria: * adults * hospitalized exclusion criteria: * surgical patients * pregnant patients

Keywords: vte dvt pe risk assessment risk score risk analysis venous thromboembolism risk
clinical and therapeutic impact of molecular markers in myeloproliferative disorders

Conditions: Myeloproliferative Neoplasms

Summary: myeloproliferative neoplasms (mpn) are clonal hematopoietic disorders sharing a common natural evolution: a chronic phase, characterized by a major risk of vascular events, followed by an accelerated phase eventually leading to transformation to acute leukemia. mpn include polycythemia vera, essential thrombocythemia, primary myelofibrosis, and rarer entities. during the past years, cml became a paradigm for targeted therapy and personalized cancer medicine. for other mpns, the discovery of the jak2v617f mutation followed by many other mutations, opened similar perspectives. however, several questions remain to be answered in mpns regarding the clinical implication of these major scientific discoveries: what is the clinical impact of jak2v617f and other molecular biomarkers on the risks of complications and progression? can these new biomarkers be used in the perspective of a personalized therapy of mpns? his project will focus on the qualification of a series of known mutations as biomarkers in mpns based on large multicenter cohorts of patients with well-annotated samples


Eligibility criteria:
inclusion criteria: * patients suffering from myeloproliferative neoplasms (mpn) diagnosed between 2005 and 2013 * sample dna diagnostics available: 500 mcg * untreated or treated with hydroxyurea, ruxolitinib, alpha interferon, * patient has given his(her) own consent for the use of the sample for research on the pathology and genetic analyzes exclusion criteria: * refused to participate * patient treated with another molecule that hydroxyurea, ruxolitinib, or alpha interferon
national recommendations and the actual rehabilitation provided for low back pain patients

Conditions: Guideline Adherence; Low Back Pain

Summary: purpose and background: the purpose of the study is to investigate physiotherapeutic courses of rehabilitation in the primary sector for low back pain patients. this is done by identifying both how physiotherapeutic rehabilitation is organized in the primary sector and further what different types of physiotherapeutic interventions are offered for this patient group. furthermore the study aims to evaluate to what extent existing physiotherapeutic rehabilitation practice adheres with the national and international guidelines and recommendations for low back pain rehabilitation. methods: a quantitative survey is carried out, which includes development and validation of a questionnaire for the purpose, and this is subsequently distributed electronically to private and public providers of physiotherapy rehabilitation in all 19 municipalities in central denmark region. approximately 500 physiotherapists will be asked to participate in the survey in the period february to march 2018.


Eligibility criteria:
inclusion criteria: * physical therapists working with low back pain rehabilitation in the primary sector in central denmark region exclusion criteria: * physical therapists that have less than 1 consultation per week with low back pain patients.
randomized, double blind, multicenter study of the safety and efficacy of valdecoxib 40 mg once daily compared with diclofenac 75 mg twice daily in acute low back pain

Conditions: Low Back Pain

Summary: the pain relief, safety, and tolerability of valdecoxib 40 mg once daily compared with diclofenac 75 mg twice daily for acute low back pain was studied. the effect of valdecoxib on the patient's level of disability and quality of life was also studied.


Eligibility criteria:
inclusion criteria: * acute low back pain, defined as either class 1a or class 2a according to the quebec task force classification and categorized as moderate-severe in the pain intensity categorical scale and visual analogue score (vas) greater or equal to 50 mm * acute low back pain was to have started at least 72 hours prior to inclusion in the trial and more than 6 weeks after the last episode of acute low back pain * history of at least 1 reported episode of acute low back pain in the last 5 years exclusion criteria: * history of inflammatory arthritis, chronic pain, metastasis, paget's disease, or other diseases known to cause pain * moderate to severe scoliosis * back pain due to major trauma or visceral disorder * unwilling to refrain from commencing concomitant physiotherapy * active or suspected esophageal, gastric pyloric channel, or duodenal ulceration or bleeding within 30 days prior to the first dose of study medication * any known laboratory abnormality, which in the opinion of the investigator, would contraindicate study participation * subject was pregnant or lactating woman , or was a woman of childbearing potential not using an acceptable method of contraception

Keywords: acute low back pain
effects of different revascularization strategies in complex coronary artery disease (edge)

Conditions: Coronary Artery Disease

Summary: coronary heart disease is one of the most serious diseases that endanger people's health. complex coronary artery disease is critical and has high mortality. therefore, it is urgent to explore the best treatment method for complex coronary artery disease. some previous studies have shown that patients with left main coronary artery disease with a syntax score\> 32 points, and diabetic/non-diabetic three-vessel disease patients with coronary heart disease with a syntax score \> 22 points, cabg is recommended for revascularization. however, with the continuous innovation of surgical technology and the rapid development of surgical instruments, the treatment of patients with complex coronary artery disease is increasing. therefore, it is necessary to investigate the effects of different revascularization strategies on long-term prognosis in patients with complex coronary artery disease (syntax score \> 22 points).


Eligibility criteria:
inclusion criteria: 1. male/female aged 18-80 years; 2. having complex coronary artery disease (syntax score \> 22 points) undergoing myocardial revascularization exclusion criteria: 1. cardiogenic shock or hemodynamic instability; 2. undergoing other heart surgery at the same time; 3. previous coronary artery bypass surgery; 4. history of cerebral hemorrhage; 5. ischemic stroke in the past six months; 6. history of cancer; 7. life expectancy no more than 12 months

Keywords: pci cabg hcr complex coronary artery disease