Kornimate/medical-research-clean huggingface dataset:
effects of visual feedback therapy on post burn children

Conditions: Burn Hand

Summary: visual feedback therapy is a cheap, easy, and, most importantly, patient-directed treatment that may improve the recovery of hand motor functional skills. visual feedback therapy consists of repeated bilateral, symmetrical movements in which the patient moves the affected body part as much as he/she could while observing the reflection.the hands account for less than 5 % of total body surface area. many burns requiring hospitalization involve the upper extremity considered severe injuries by the american burn association and should be referred to specialized care centers to minimize sequella of thermal injury including nail deformities, hypertrophic scars, boutonniere deformity, digit loss, and contractures. visual feedback therapy is a treatment method based on neuroplasticity of the brain.although recent studies have demonstrated the benefit of visual feedback therapy for various diseases, research that applies visual feedback therapy to improve the restorative capability of hand function of patients with reduced hand function due to mutilated injury has not been reported yet.

this study will be a randomized controlled trial. study will be approved by ethical committee. after that informed consent will be taken and patients will be included in the study based on the inclusion criteria. non probability convenience sampling technique will be used and study will be conducted on 36 patients diagnosed with post burn hand contractures 8-12 years old children. patient will be randomly categorized into two groups by using flip coin method. experimental group will receive visual feedback therapy and conventional therapy treatment protocol. control group will receive only conventional therapy. pre and post interventions assessment will be made for both groups. post burn hand contractures of the patients will be assessed by checking roms of hands with goniometer. the abilhand questionnaire will also be performed to check the functional movements of hands and visual analogue scale will be used for pain assessment. data will be analyzed by using spss 25.0 statistical tool. appropriate statistical test will be used after checking normality of data.

Eligibility criteria:
inclusion criteria: * 8 to 12 years old children with post burn hand contractures * patients with flame burns * patients with 2nd degree burns exclusion criteria: * patients with hand burns with any post burn complications * patients with wound infections * patients with 3rd degree burns patients with hand fractures

Keywords: burns, goniometer, hand contractures visual feedback therapy
recover-energize platform protocol_appendix b (structured pacing (pem))

Conditions: Long COVID; Long Covid19; Long Covid-19

Summary: this is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical covid-19 management programs and treatment plans if results achieve key study outcomes. this protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating interventions to address and improve exercise intolerance and post-exertional malaise (pem) as manifestations of post-acute sequelae of sars-cov-2 infection (pasc). the focus of this protocol is to assess interventions that can improve exercise capacity, daily activities tolerance, and quality of life in patients with pasc.

study interventions will be added to the platform protocol as appendices. each appendix will leverage all elements of the platform protocol, with additional elements described in the individual appendix. study intervention appendices may be added or removed according to adaptive design and/or emerging evidence. the platform protocol enrolls participants who meet study eligibility criteria. after completing initial screening assessments, eligible participants are assigned to one of the study intervention appendices that are actively enrolling. participants must meet certain criteria within a specific appendix in order to be included in that appendix. once assigned to an appendix, eligible participants are randomized to either the study intervention group or a control group.

Eligibility criteria:
• see nct06404047 for recover-energize: platform protocol level inclusion and exclusion criteria which applies to this appendix additional appendix b (structured pacing (pem)) level inclusion criteria: 1. participant identifies new pem following a sars-cov-2 infection that has persisted for at least 12 weeks and is still present at the time of consent 2. score of 2 or greater for both frequency and severity for any of the first 5 questions on the screening mdsq-pem and answer of yes to either item 7 or 8 on screening mdsq-pem, and response of \>14 h in item 9. or score of 3 or greater on any severity question(regardless) and answer of yes to either item 7 or 8 on the screening mdsq-pem, and response of \>14h in item 9. additional appendix b (structured pacing (pem)) level exclusion criteria: 1. inability to attend in-person screening visit or participate in weekly visits (in-person \[≥ 1\] and remote) 2. participant was previously enrolled in appendix a of this protocol and has not completed the full study follow-up period of appendix a

Keywords: pasc exercise pem (post exertional malaise)
gut hormone response, appetite and intestinal transit time in good and poor weight responders after gastric bypass

Conditions: Obesity

Summary: the aim of the study is to describe differences in meal-stimulated gut hormone response, appetite and intestinal transit time between good and poor responders 1-2 years after gastric bypass surgery for obesity.


Eligibility criteria:
inclusion criteria: * age 20-60 years * completed laparoscopic gastric bypass surgery without complications (cases) * no previous gastric bypass surgery (controls) exclusion criteria: * diabetes * disease or treatment interfering with appetite or gastrointestinal motility * pregnancy or breastfeeding * excess weight loss 1 year after gastric bypass \> 50% and =\< 60% (cases)

Keywords: obesity gastric bypass gut hormone intestinal transit time
a study to evaluate the efficacy and safety of br1019a and br1019b combination therapy

Conditions: Essential Hypertension; Type 2 Diabetes Mellitus

Summary: the objective of this clinical study is to evaluate the efficacy and safety of br1019a and br1019b combination therapy in patients with essential hypertension and type 2 diabetes mellitus


Eligibility criteria:
inclusion criteria: * those with type 2 diabetes mellitus \& essential hypertension * those who agree to discontinue existing antihypertensive and/or oral hypoglycemic drugs during the clinical trial * those who are judged medically reasonable by investigator to be able to discontinue existing antihypertensive and/or oral hypoglycemic drugs(except for metformin) during the clinical trial exclusion criteria: * those who meet the following criteria * those with a history of secondary hypertension or suspected secondary hypertension; (including but not limited to; e.g., renovascular disease, adrenal medullary and cortical hyperfunctions, coarctation of the aorta, primary hyperaldosteronism, unilateral or bilateral renal artery stenosis, cushing's syndrome, pheochromocytoma and polycystic kidney disease, etc.) * those with clinical significant orthostatic hypotension accompanied by symptoms * those with diabetes mellitus taking renin inhibitors(aliskiren) or moderate to severe renal impairment * those with diabetic nephropathy taking ace inhibitors * those with type 1 diabetes mellitus, secondary diabetes mellitus, severe insulin-dependent diabetes, diabetic ketoacidosis or lactic acidosis * those with uncontrolled, severe diabetic complications (micro-vascular complications(e.g., nephropathy, retinopathy, neuropathy, etc.), macro-vascular complications) * diabetic coma or pre-coma
using immersive virtual reality to treat pediatric anxiety

Conditions: Specific Phobia; Specific Phobia, Situational; Specific Phobia, Animal; Specific Phobia, Natural Environment; Childhood Anxiety Disorder

Summary: anxiety is a common and impairing problem for children. the principle treatment for pediatric anxiety involves facing a child's fears in a stepwise approach through a therapeutic exercise called exposures. while exposures are effective, some feared situations cannot be confronted in a clinician's office (e.g., heights, public speaking, storms). this poses a logistical challenge in treatment that: (1) takes time away from patient care, (2) leads clinicians to rely on imagined exposures, and/or (3) requires families to complete exposures outside of the therapy visits. this creates a burden for clinicians and families, and impedes treatment success. immersive virtual reality (vr) presents an innovative solution that allows children to face fears without leaving the clinician's office. while vr has been used to distract children during painful medical procedures, it has not been well examined as a primary treatment for pediatric anxiety. this study proposes to examine the effectiveness and acceptability of using immersive vr exposures to treat children and adolescents with specific phobias.


Eligibility criteria:
inclusion criteria: * 8-17 years (inclusive), * meet diagnostic criteria for one or more phobias on a structured diagnostic interview (adis-c/p). this specifically includes natural environments (e.g., storms, heights) and/or situational settings (e.g., airplanes, public speaking). * be fluent in english. exclusion criteria: * unable to complete rating scales, or * attend study visits.

Keywords: exposure therapy virtual reality
the effect of exercise-oriented training on physical activity level and exercise awareness in overweight and obese women

Conditions: Obesity; Overweight; Physical Inactivity

Summary: this study aimed to investigate the effect of an exercise-oriented training on physical activity level and exercise awareness in overweight and obese women. participants will randomized into intervention group (ig) and control group (cg) and followed-up for three months. the international physical activity questionnaire short form (ipaq) will be applied to both groups at the beginning and end of the study to determine the level of physical activity, and the exercise health belief model scale (ehbm) will be applied to evaluate the exercise awareness level, and anthropometric measurements (weight, body mass index, waist circumference) will recorded. the cg will receive no other interventions other than routine recommendations. the ig will be given face-to-face training to increase exercise awareness along with routine recommendations after the first meeting, and they will be contacted by phone every two weeks for three months.

obesity and insufficient physical activity are among the most important health problems of today. both obesity and physical inactivity are risk factors for many chronic diseases. this study aimed to investigate the effect of an exercise-oriented training on physical activity level and exercise awareness in overweight and obese women. participants (n=112) were randomized into intervention group (ig) and control group (cg) and followed-up for three months. the international physical activity questionnaire short form (ipaq) was applied to both groups at the beginning and end of the study to determine the level of physical activity, and the exercise health belief model scale (ehbm) was applied to evaluate the exercise awareness level, and anthropometric measurements (weight, body mass index, waist circumference) were recorded. the cg received no other interventions other than routine recommendations. the ig was given face-to-face training to increase exercise awareness along with routine recommendations after the first meeting, and they were contacted by phone every two weeks for three months.

Eligibility criteria:
inclusion criteria: * bmi 25-34.9 g/m2 * female * turkish exclusion criteria: * individuals with disabilities to exercise * pregnant/breastfeeding women * individuals with stage 2-3 obesity (bmi \>35 kg/m2)
the lysa (linking you to support and advice) trial

Conditions: Survivorship; Breast Cancer; Cervical Cancer; Endometrial Cancer

Summary: this study's aim is to evaluate the feasibility of introducing a women's malignancy survivorship clinic incorporating symptom management through epro collection (complex intervention) into routine follow up care in patients with early-stage hormone receptor(hr)-positive breast and gynaecologic cancer post primary curative therapy.

study design: complex interventional study. specific aims: to evaluate the feasibility of introducing a women's malignancy survivorship clinic in ireland incorporating symptom management through electronic patient reported outcomes (epros) collection (complex intervention) into routine follow-up care in patients with early-stage hr-positive breast and gynecologic cancer post-primary therapy. sampling method: randomized control design (parallel arms). sample size: 200. entry criteria: women with early-stage breast/gynecologic cancer within 12 months of completion of primary curative therapy: * breast cancer: stage i-iii hormone receptor-positive (defined as estrogen receptor and/or progesterone receptor ≥ 1%) and her2-negative per asco-cap guidelines on or recommended to commence adjuvant endocrine therapy during the study period. * cervical cancer: stage i to iii treated with curative intent. * endometrial cancer: treated with curative intent adjuvant radiotherapy +/- chemotherapy

Eligibility criteria:
inclusion criteria: 1. women aged \> or = 18 years. 2. ability to read and understand english. 3. access to internet. 4. early-stage breast/gynaecologic cancer within 12 months of completion of primary curative therapy: * breast cancer: stage i-iii hormone receptor-positive (defined as estrogen receptor and/or progesterone receptor ≥ 1%) and her2-negative per asco-cap guidelines on or recommended to commence adjuvant endocrine therapy during the study period. * cervical cancer: stage i to iii treated with curative intent. * endometrial cancer: treated with curative intent adjuvant radiotherapy +/- chemotherapy exclusion criteria: 1. patients who are not treated with curative intent as above. 2. patients with premalignant disease. 3. persons who, in the opinion of the researcher or supervising clinician, are unable to cooperate adequately with the study protocol. 4. recent (within 12 months) participation in a study/programme involving a lifestyle intervention (e.g diet, exercise, survivorship). note: per discretion of pi as to whether may impact the outcome of this study intervention.

Keywords: survivorship complex interventional study randomised electronic patient reported outcomes breast cancer cervical cancer endometrial cancer nurse lead clinic dietitian intervention nurse intervention symptom management quality of life self-care agency
control of blood loss during caesarean section

Conditions: Complications; Cesarean Section

Summary: trial of 3 protocols to determine the best one to control blood loss during caesarean section

the study population will be divided into 3 groups each containing 200 women: group (a): 200 patients will receive 5-iu oxytocin bolus over 3 minutes after delivery of the baby. group (b): 200 patients will receive 5-iu oxytocin bolus over 3 minutes and 30-iu oxytocin infusion in 500 ml 0.9 % saline over 4 hours after delivery of the baby. group (c): 200 patients will receive misoprostol 800 micrograms intrauterine, placed manually on the bottom of the uterine cavity after delivery of the placenta and cleaning of the cavity. operative blood loss will be estimated in theatre based on the volume in the suction bottle and the weight of swabs used. we will record blood loss up until the time the woman will be discharged from the theatre recovery ward. hemoglobin level and haematocrit value will be done as follow:- 1. after admission of each case in the pre-operative period. 2. immediately post- operative. 3. 24 hours post- operative.

Eligibility criteria:
inclusion criteria: * patients booked for elective cesarean section. * singleton pregnancies. * primigravida or multipara ,first cesarean section or previous . exclusion criteria: * patients with obstetric hemorrhage. * uterine laceration. * placenta previa. * blood dyscrasias. * large fibroids. * multiple pregnancy. * pre-eclampsia. * marked maternal anemia. * previous history of pph.

Keywords: caesarean section, intrapartum haemorrhage
low-osmolar water soluble contrast agent in management of adhesive small bowel obstruction

Conditions: Small Bowel Adhesion; Small Bowel Obstruction

Summary: adhesive small bowel obstruction (asbo) is a condition that is commonly found in patients with history of abdominal surgery. the management for such condition can be controversial. in terms of conservative treatment, recent studies have shown conflicting outcomes on whether water soluble contrast would provide benefit in reducing number of patients needed for surgery. in addition, there are a limited number of literature that investigates the role of low-osmolar contrast in reducing operative need in patients diagnosed with asbo. the objective of this study is to compare the operative rate of patient diagnosed with asbo between patients who were treated with low osmolar water soluble contrast (iohexol) and patients who were treated traditionally.

this study is a randomized, controlled and double-blinded study, where participants who were diagnosed with asbo will be randomly allocated into two groups: (i) a contrast group (cg): patients will be treated conservatively and received omnipaque (iohexol) via nasogastric tube (ii) a traditional group (tg): patients will be treated conservatively and received sterile water via nasogastric tube after obtaining informed consent, the patient will be administered with either 100 ml of 350 mg omnipaque or 100 ml of sterile water via nasogastric tube. the nasogastric tube will be clamped for 1 hour and patient will be positioned with 30 degree head elevation. in the contrast group (cg), surgery is indicated when contrast failed to reach the colon. failure of conservative treatment is considered when there are no clinical improvements after 48 hours and the patient will then be proceeded for surgery.

Eligibility criteria:
inclusion criteria: * patients who are presented with clinical manifestation of small bowel obstruction due to adhesion and require radiological investigations * patients who has history of abdominal surgery over 30 days exclusion criteria: * patients with clinical signs and symptoms of bowel strangulation, ischemia, perforation or peritonitis * patients with clinical signs and symptoms of bowel obstruction from non-adhesive causes, including malignancy, herniation, inflammatory bowel disease, crohn's disease, and others. * patients who has history of allergy to water soluble contrast agent
physical conditioning in management of chronic venous insufficiency

Conditions: Venous Insufficiency

Summary: the purpose of this research is to evaluate the efficacy of a structured program of physical therapy in ameliorating the adverse consequences of chronic venous insufficiency (cvi). the study will also investigate the interrelationship among measure of chronic venous diseases: lower limb muscle strength, mobility, and other symptoms of cvi important to the quality of life. sixty patients will be randomized to a 6 months physical therapy program or to a control group.

the purpose of this research is to evaluate the efficacy of a structured program of physical therapy in ameliorating the adverse consequences of chronic venous insufficiency (cvi). a secondary purpose is to investigate the interrelationship among measure of chronic venous diseases: lower limb muscle strength, mobility, and other symptoms of cvi important to the quality of life. sixty patients will be randomized to a 6 months physical therapy program or to a control group. all subjects will undergo a complete hemodynamic and psychiatric assessment. key measures will be repeated twice to quantify trend and stability of the baseline measures. skin biopsies will be obtained in selected patients who demonstrate a response to the physical therapy to evaluate the ultrastructural response therapy. physical therapy will be conducted 1-3 times per week. participants will be visited at home and a program will be tailored for each individual to maximize compliance. validated, standardized questionnaires (fim, sf-36, oars, chart) and functional ratings will be employed at commencement,3,6 and 12 months. evaluations of hydrodynamics, muscle strength, and ankle motion will be conducted monthly during active physical therapy. participants in active therapy will be offered to wait listed control group after 6 months.

Eligibility criteria:
patients with severe form of chronic venous insufficiency

Keywords: venous insufficiency, plethysmography, hypertension
neosamba: neoadjuvant: does the sequence of anthracycline and taxane matters: before or after?

Conditions: Breast Cancer

Summary: the purpose of this study is to evaluate the usual and the reverse sequence of an anthracycline followed by a taxane in locally advanced breast cancer.

anthracylines and taxanes are the most active chemotherapy agents in the treatment of breast cancer. the usual sequence of an anthracycline followed by a taxane is due to the timing of their discovery and introduction in the treatment armamentarium. more recent evidence suggests that there is pre clinical as well as clinical rational for the reverse sequence. the neoadjuvant approach allows quick evaluation of these different treatment strategies. at the same time, the study will collect tissue biopsies and blood at different time points in order to evaluate predictive biomarkers.

Eligibility criteria:
inclusion criteria: 1. stage iib to iiib her-2 negative breast cancer 2. ecog performance status ≤ 2 3. neuropathy grade \<1 by the common terminology criteria for adverse events version 3.0 (ctcae v 3.0) 4. adequate hematologic function with: * absolute neutrophil count (anc) \>1500/μl * platelets ≥100,000/μl * hemoglobin ≥ 9 g/dl 5. adequate hepatic and renal function with: * serum bilirubin ≤ 1.5 x the institutional upper limit of normal (uln) * aspartate aminotransferase (ast) and alanine aminotransferase (alt) ≤2.5 x institutional uln * alkaline phosphatase ≤2.5 x institutional uln * serum creatinine ≤1.5 x uln or calculated creatinine clearance ≥ 50 ml/min 6. adequate cardiac function * left ventricular ejection fraction (lvef) within institutional normal range 7. knowledge of the investigational nature of the study and ability to provide consent for study participation exclusion criteria 1. pregnancy 2. bilateral, synchronous breast cancer 3. previous diagnosis of breast or other cancer 4. any other disease(s), psychiatric condition, metabolic dysfunction, that contraindicates the use of study drugs or that would make the patient inappropriate for this study

Keywords: neoadjuvant therapy drug therapy
plasma protein binding characteristics of voriconazole

Conditions: Focus of the Study:Protein Binding Characteristics of Voriconazole.

Summary: the purpose of this study is to investigate the influence of hypoalbuminemia on the protein binding characteristics of the antifungal drug voriconazole in icu patients.


Eligibility criteria:
inclusion criteria: * treated with voriconazole exclusion criteria: * none

Keywords: protein binding voriconazole pediatrics hematology intensive care albumin alpha-1-acid-glycoprotein