Kornimate/medical-research-clean huggingface dataset:
a real-world study to assess the characteristics and long-term effectiveness of inclisiran in chinese adult patients

Conditions: Hypercholesterolemia

Summary: this was a single-center, retrospective, observational study (non-interventional study with secondary use of data) among patients in a real-world setting. this study used the medical record data from patients in yiling. eligible patients who newly initiated inclisiran from 26 january 2022 to 21 august 2023 were included. the retrospective data up to the date of ethics committee approval (april 2024) was collected. the study team collected patient data using an electronic case report form (ecrf) from april 2024 to june 2024.


Eligibility criteria:
inclusion criteria: * received at least one inclisiran injection during the indexing period. * had at least 9 months of follow-up from the index date (had at least one ldl-c assessment during baseline period and at least one ldl-c assessment at 9 months or later). * patients signed the informed consent form. exclusion criteria: • participated in any blinded interventional clinical studies anytime during the study period.

Keywords: elevated low-density lipoprotein cholesterol inclisiran real-world
the effect of occupational therapy intervention in hemodialysis patients

Conditions: Quality of Life

Summary: the aim of this study is to investigate the effect of person-centre occupational therapy intervention on activity performance and quality of life in hemodialysis patients. the results of the study will guide the intervention programs for prevention, coping and improving the quality of life of hd patients.


Eligibility criteria:
inclusion criteria: * diagnosed as chronic renal failure. * between 18-65 years * undergoing hd treatment for at least 1 year exclusion criteria: * beck depression scale score of 17 or higher
a study of apg-2575 in patients with mild-to-moderate systemic lupus erythematosus.

Conditions: SLE

Summary: to evaluate the safety, tolerability, pharmacokinetics and pharmacokinetics of multi-dose apg-2575 in mild-to-moderate systemic lupus erythematosus (sle).

this is a randomized, double-blind, placebo-controlled phase i/ii study. about 40 participants will be recruited to receive either apg-2575 or a placebo, with doses from 200mg up to 800mg.

Eligibility criteria:
inclusion criteria: * 1. diagnosis of systemic lupus erythematosus for at least 6 months. * 2. on stable treatment for systemic lupus erythematosus before first dose at least 28 days. * 3. sledia-2000 score: 4-12 * 4.other than systemic lupus erythematosus, subject should be in general good health. exclusion criteria: * 1. severe systemic lupus erythematosus. * 2. significant autoimmune disease other than lupus. * 3. significant, uncontrolled or unstable disease in any organ.

Keywords: sle apg-2575
the impact of equine-assisted psychotherapy on depression, anxiety, and stress in patients with substance use disorder in a psychiatric hospital

Conditions: Substance Abuse Disorder; Anxiety; Depression Secondary to Other Disease

Summary: this study aims to assess whether an eap program affects anxiety, depression, and stress, which are often associated with substance use disorder. the management of these conditions has a major impact on the control of the addiction.

this study aimed to evaluate the effect of an eap program on 32 respondents in the experimental group and 36 in the control group. these respondents were patients in a psychiatric hospital who were taking part in an addiction treatment program. the eap program was conducted weekly over four weeks, with each session lasting three hours. the treatment effects were assessed using the stai-y modules 1 and 2, bai, pss, and dass-21 questionnaires. the groups were compared before and after the four-week observation period.

Eligibility criteria:
inclusion criteria: patients of psychiatric hospital of kosmonosy with substance use disorder exclusion criteria: exclusion criteria were possible cognitive deficit or reluctance to work with animals. participants who did not complete all required materials or left the treatment program before completion were excluded from the study (n = 9).

Keywords: equine asssited psychotherapy substance use disorder psychotherapy
analysis of the patients who need rehospitalization due to stroke rehabilitation only

Conditions: Stroke Rehabilitation

Summary: the aim of this study was to investigate the clinical and laboratory data of patients who were rehospitalised due to "stroke rehabilitation cause only" the patients who were hospitalized in the hospital between january 2015 and july 2018, according to icd 10 code; hemiplegia (g81), flaccid hemiplegia (g81.0), hemiplegia, unspecified (g81.9), spastic hemiplegia (g81.1) scanned from the hospital database.

all comorbid diseases were included to rehospitalisation rates in stroke patients in the literature. the aim of this study was to investigate the clinical and laboratory data of patients who were rehospitalised due to "stroke rehabilitation cause only" the patients who were hospitalized in the hospital between january 2015 and july 2018, according to icd 10 code; hemiplegia (g81), flaccid hemiplegia (g81.0), hemiplegia, unspecified (g81.9), spastic hemiplegia (g81.1) scanned from the hospital database. there were 554 patients with these diagnoses. 9 patients of them were excluded because of the hemiplegic due to trauma, cancer and intracranial operation. detailed epicrisis of 545 patients with ischemic or hemorrhagic stroke were examined. 328 patients who did not have missing data were included in the study. age, sex, hemiplegia etiology, admission season, hemiplegia time, hemiplegic side, 25 (oh) vitamin d and vitamin b12 levels, brunnstrom stage of upper extremity, lower extremity and hand functional ambulation classification (fac). brunnstrom staging was used to identify motor function with 6 levels in the upper extremity and hand. rom for abduction, flexion, internal rotation, and external rotation were passively measured. brunnstrom staging was used to evaluate motor development, and stroke patients were defined as 6 stages. the flask phase without the lowest voluntary movement is considered to be stage 1, while the presence of isolated movements is considered to be stage 6. in the brunstromm staging, upper, lower extremity and hand evaluation are performed separately. fac is defined as 5 stages according to the basic motor skills required for functional ambulation. fac stage 0 is used for non-functional ambulation, stage 5 is used for independent walking at each speed and ground.

Eligibility criteria:
inclusion criteria: * being hospitalized in the hospital between january 2015 and july 2018, according to icd 10 code; hemiplegia (g81), flaccid hemiplegia (g81.0), hemiplegia, unspecified (g81.9), spastic hemiplegia (g81.1) * being ischemic or hemorrhagic stroke exclusion criteria: * being hemiplegic due to trauma, cancer and intracranial operation
a randomised controlled trial to investigate the effects of a mindfulness smartphone app on well-being in the workplace

Conditions: Well-being, Work Stress

Summary: we propose a randomised controlled trial in a workplace setting to investigate whether a smartphone-delivered programme of mindfulness meditation influences psychological and biological indicators of well-being. we hypothesise that after 8 weeks participants who complete the meditation programme will show increases in psychological well-being and reduced activation of stress-related biological pathways.

mindfulness-based therapies can reduce depressive symptoms in patients and healthy subjects. therapies such as mbsr (mindfulness-based stress reduction) typically consist of 8 group sessions led by an experienced practitioner, plus home practice and one full day of meditation. in this study we aim to investigate whether a mindfulness programme delivered as a series of podcasts on a mobile phone app could lead to gains in well-being and a reduction in stress.

Eligibility criteria:
inclusion criteria: * employees of a uk high-tech company * raised levels of work stress (overcommitment\>2) or depression (cesd\>1) exclusion criteria: * treated for anxiety, depression or hypertension * taking medication containing steroids

Keywords: mindfulness meditation stress well-being work stress blood pressure cortisol
thoracoscopic sympathectomy for blushing

Conditions: Facial Blushing

Summary: to determine outcome and side effects following thoracoscopic sympathectomy in patients treated for disabling isolated facial blushing and investigate if there are any significant differences between two different routine procedures: t2 or t2-t3 sympathectomy.

to determine the outcome and side effects following thoracoscopic sympathectomy in patients treated for disabling isolated facial blushing. in addition, following randomization investigate if there are any significant differences between two different routine procedures: t2 or t2-t3 sympathectomy. includes qol before and 12 months after surgery

Eligibility criteria:
inclusion criteria: * isolated disabling facial blushing * over 18 years of age * willing to be randomized exclusion criteria: * primary hyperhidrosis in palms or axillae * previous lung surgery * bradycardia * arrythmias * pregnancy

Keywords: facial blushing sympathectomy
opsoclonus myoclonus syndrome/dancing eye syndrome (oms/des) in children with and without neuroblastoma (nbpos and nbneg)opsoclonus myoclonus syndrome/dancing eye syndrome (oms/des) in children with and without neuroblastoma (nbpos and nbneg)

Conditions: Opsoclonus Myoclonus Syndrome; Neuroblastoma

Summary: the oms/des study is a multinational european trial for children with the opsoclonus myoclonus syndrome / dancing eye syndrome. this trial brought on the way by specialists of the epns (european paediatric neurology society), the gpoh (gesellschaft für pädiatrische hematologic und oncologie) and the siopen (siop (international society oncology pediatric) europe neuroblastoma). this protocol will investigate an escalating treatment schedule starting with a corticosteroid standard treatment with dexamethasone pulses (first step), which is followed, if response has been inadequate after 3 months of treatment, by the addition of cp (second step) and, if still no sufficient improvement, by the replacement of cp by rituximab (third step). treatment intensification is decided on the basis of standardized scoring of oms/des severity.


Eligibility criteria:
inclusion criteria: * children with newly diagnosed oms/des either nb-pos or nb-neg. three out of the following four components are necessary for the diagnosis of oms/des: * opsoclonus or ocular flutter (but not nystagmus) * ataxia and/or myoclonus * behavioural change and/or sleep disturbance * neuroblastoma the diagnosis of oms/des may be difficult in some patients. opsoclonus, in particular, may be intermittent or late in onset. a video example will be available at www.dancingeyes.org.uk. if uncertain, please contact the national coordinator for support in interpreting clinical features. * age 6 months or over up to less than 8 years (\< 8th birthday) the date of diagnosis of oms/des is the date on which a doctor confirms the condition to be oms/des. the date of symptom onset needs also to be documented. * treatment start with the standard corticosteroid treatment with dexamethasone pulses as proposed by the guidelines given in this trial protocol (see 11.10, page 71). * in patients with presumed nb-neg oms/des, neuroblastoma must be excluded according the guidelines of this trial (see chapter 4.4.1.4, page 30, and appendix 11.9, page 70) * documented informed consent for treatment and enrolment in the trial by parents / legal representatives. exclusion criteria: •patients with opsoclonus, myoclonus or ataxia caused by other identified disease (e.g. current active cns infection, neurometabolic disorder or demyelination). an identified viral precursor is not an exclusion criterion. * prior or parallel use of chemotherapy (other than required for treatment of the neuroblastoma) * corticoid steroid for oms/des or other reasons lasting 14 days or more immediately before treatment start according the standard treatment proposed (treatment with corticosteroids for less than 14 days will be allowed) * contre-indication of use of one of the experimental study drug (cf summary of product characteristics used in this study)
92/5000 preoperative efficacy of traumeel versus dexamethasone in the control of pain, swelling and trismus

Conditions: Molar, Third; Surgery

Summary: to compare the efficacy of intramuscular injection of two anti-inflammatory drugs, traumeel and dexamethasone, used in the control of postoperative complications pain, edema and trismus after third molar extraction mandibular


Eligibility criteria:
inclusion criteria: * patients with indication of asymptomatic bilateral extractions of lower third molars; * aged 18 years or older; * have a good health and no disease. exclusion criteria: • patients with history of any medication treatment within 15 days before the beginning of the research, history of allergy to the drugs, substances or materials used in this study, pregnancy or lactation

Keywords: third molar surgery swelling
fluorescent cholangiography during acute cholecystitis

Conditions: Acute Cholecystitis

Summary: this study compares the visualizationrate of fluorescent and x-ray cholangiography during laparoscopic cholecystectomy for acute cholecystitis


Eligibility criteria:
inclusion criteria * patient scheduled for acute laparoscopic cholecystectomy due to acute cholecystitis with ≤ 5 days of complaints (in denmark the national consensus for surgical window) exclusion criteria * laparoscopic operation converted to open operation prior to completed fluorescent and x-ray cholangiography * allergy towards iodine, iohexol or indocyanine green * legally incompetent (any reason) * cholangitis (as defined above)15 * withdrawal of inclusion consent at any time

Keywords: fluorescence cholangriography cholecystectomy
effect of a virtual reality program on patient comfort in the surgical intensive care unit

Conditions: Immersive Virtual Reality; Discomfort; IPREA; Intensive Care Unit; Delirium

Summary: admission to a surgical intensive care unit (icu) following major surgery is associated with a number of discomforts, not only related to the disease itself, but also to the care provided or the icu environment itself (lights, sounds, pain, sleep deprivation, thirst...). this discomfort is real, and can be associated with psychological consequences. the investigators hypothesized that the use of immersive virtual reality (ivr) with hypnovr® is feasible and can help reduce discomfort in intensive care.the zion trial is a prospective, monocentric trial, randomizing 194 patients admitted in a surgical intensive care unit after a major surgery. the inclusion criterion are patients admitted in a surgical intensive care for at least 48 hours following major surgery (cardiac, thoracic or major abdominal surgery). patients will be allocated to the intervention group (n=97) or the control group (n=97). in the intervention group, patients will receive ivr using hypnovr®, twice a day, during the icu stay (2 to 5 days). in the control group, postoperative care will be conducted according to standard cares without ivr. the primary endpoint will be the 18-items iprea questionnaire on the day of icu discharge or at day 5 after ivr initiation. the secondary endpoints will include intensity of discomfort symptoms (anxiety, pain, dyspnea, thirst and sleep deprivation), the 18-item iprea questionnaire assessed daily from randomization to v1 follow-up visit (icu discharge or at day 5 after ivr initiation), incidence of delirium, cumulative morphine consumption at icu discharge, length of icu stay, and anxiety or depression at 1 month after discharge from intensive care and patient experience of device use.


Eligibility criteria:
inclusion criteria: * patients over 18 years old * scheduled for a major surgery (cardiothoracic surgery or a major abdominal surgery) * written informed consent from patient or next of kin. * admitted in a surgical icu for a postoperative care for at least 48 hours. * absence of delirium at inclusion (rass and cam-icu scale) exclusion criteria: * missing informed consent * patient strictly under 18 years old * inclusion in other study within the last 30 days * pregnancy * emergency hospitalization * progressive sepsis * patient transferred from another intensive care unit * short-term life-threatening condition * active psychiatric illness requiring antidepressant, antipsychotic or anxiolytic treatment * mechanical ventilation \> 48 hours * patient known to have cognitive disorders. * unbalanced epilepsy * visual problems (absence of binocular vision, blindness) and/or auditory problems (deafness) preventing the use of virtual reality * pregnant or breast-feeding women * patients under guardianship or deprived of their liberty * patients not registered with the national social security system

Keywords: immersive virtual reality discomfort iprea intensive care unit delirium
influence of renal replacement therapy on indirect calorimetry

Conditions: Acute Renal Failure; Mechanical Ventilation

Summary: renal replacement therapy may affect carbon dioxide elimination, which may theoretically influence measurement of energy expenditure by means of indirect calorimetry. however, available clinical studies are noct conclusive on this issue. this observational study aims to investigate the effect of renal replacement therapy on indirect calorimetry in critically ill mechanically ventilated patients.

optimal nutrition of the critically ill is still a clinical challenge. current guidelines recommend that measurement of energy expenditure using indirect calorimetry should be favoured in critically ill patients. the technique is based on measurement of oxygen consumption and carbon dioxide elimination. experimental studies have reported on carbon dioxide elimination via renal replacement therapy. since acute kidney injury with requirement for renal replacement therapy (rrt) is common in the intensive care unit, the significance of carbon dioxide elimination via the dialyser should be clarified. however, available evidence from clinical studies is contradictory, one reason being the heterogenous study design. in this prospective observational study on critically ill mechanically ventilated medical patients requiring rrt, indirect calorimetry (ic) will be conducted twice on the same day with and without rrt: either immediately before commencement of rrt followed by a second ic with rrt after an rrt run time of an hour, or immediately before the end of an rrt session followed by a second ic an hour after the termination of rrt.

Eligibility criteria:
inclusion criteria: * simultaneous requirement for mechanical ventilation and renal replacement therapy * informed consent exclusion criteria: * age \<18 years * requirement for therapeutic hypothermia * serum lactate \>4 mmol/l * requirement for inspiratory oxygen fraction \>0.6 and positive end-expiratory pressure \>12 mbar * leak in the ventilator circuit (e.g. due to a chest tube) * requirement for extracorporeal circulatory support * refusal to participate in the study.

Keywords: indirect calorimetry energy expenditure carbon dioxide elimination renal replacement therapy respiratory quotient
surveying the outcomes of lubiprostone (the stool study) in nursing home residents

Conditions: Constipation

Summary: the purpose is to assess the efficacy, clinical outcomes, and potential quality indicator benefits associated with the use of lubiprostone in nursing home residents with a confirmed diagnosis of chronic idiopathic constipation.

the study is a prospective, observational, open-label, non-placebo, controlled study to measure the effects of lubiprostone on cic in nursing home residents. all clinical sites will follow a common protocol using standardizes definitions in which eligible patients will be asked to participate in the proposed study. during the course of the study, various selected parameters will be measured and compared to establish the clinical efficacy of lubiprostone in the treatment of cic. the study sample (n=105) will be comprised of nursing home residents with a confirmed diagnosis of cic. a power analysis generated a sample size of 97 residents. to protect the validity of the test, 8 residents were added to the final study sample to allow for losses to followup. therefore, a final sample size of 105 residents was identified for the study. patients meeting the inclusion criteria will be recruited for participation in the study. 3 sites in central florida with multiple nursing homes per site will be recruited to participate in the proposed study.

Eligibility criteria:
inclusion criteria: patients must meet all of the following criteria to be eligible for the study: * adult men and women nursing home residents; * confirmed diagnosis of cic using rome criteria; * prescribed two or more laxatives, at recruitment; * taking 9 or more oral medicines (including prescription, otc and prn) * free from conditions likely to be fatal within six months; * able to read or understand english; and * able and willing to provide informed consent or has a guardian/agent who can provide consent. exclusion criteria: * currently pregnant; * presence of megacolon; * presence of rectal sigmoid cancer; * presence of colon cancer; * presence of anal incompetence; * conditions likely to be fatal within six months; * taking 8 or fewer medicines; * enrolled in hospice; * non-english speaking patients; and * unwilling or unable to provide informed consent and has no guardian/agent. * expected to be discharged within 3 months.

Keywords: constipation nursing home quality indicator