Kornimate/medical-research-clean huggingface dataset:
subjective sleep and fatigue during and after acute diverticulitis

Conditions: Acute Diverticulitis

Summary: the purpose of this study is to investigate subjective sleep quality and fatigue during and after acute uncomplicated diverticulitis assessed by questionnaires and a sleep-diary. the investigators hypothesis is that subjective sleep and fatigue are correlated with the inflammatory activities.

an increasing number of experimental studies have showed that inflammation can induce disturbances in sleep architecture, mediated by cytokines. some studies showed that cytokines also induce daytime fatigue. in this study the investigators aim to describe the patient experiences of sleep and fatigue during the acute inflammation and the recovery, and the investigators seek to exam the correlation of fatigue with polysomnography-measured night sleep and cytokine levels in plasma. following methods will be applied * other: karolinska sleepiness scale * other: physical fatigue scale * other: visual analog scale and 10 point-scales to measure fatigue, general well-being, subjective sleep and pain * other: sleep-diary * device: polysomnograph - embla titanium (natus medical incorporated, usa) * procedure: plasma cytokines (il-2, il-6 and tnf-alfa(tumor necrosis factor)) * procedure: plasma crp(c reactive protein) and leukocytes * device: wrist-actigraph - octagonal basic motionlogger, ambulatory monitoring inc, new york, usa

Eligibility criteria:
inclusion criteria: * ct-verified diverticulitis patients managed by antibiotic treatment at herlev hospital * pain and fever occurred less than 72 hours prior to the admission * asa (american society of anesthesiologists) score i to iii exclusion criteria: * surgical intervention needed * complicated diverticulitis * complications in relation to diverticulitis * pain and fever occurred more than 72 hours prior to the admission * in anticoagulant treatment and heart rate control treatment * known autoimmune disease * known medically treated sleep-disorder (insomnia, restless legs etc.) and sleep apnea * shift-work or jetlag * daily use of opioid, psychopharmaca, opioids or anxiolytics (including hypnotics) * known psychiatry conditions in treatment with psychopharmaca * daily alcohol intake of more than 5 units or drug abuse * missing written consent * diabetes mellitus * predicted bad compliance * pregnant or breast-feeding * urine or fecal incontinence * severe kidney disease * current cancer
menstrual cycle phase and diabetes management

Conditions: Type 1 Diabetes Mellitus

Summary: this study examines how menstrual cycle phases affect glycemic control and insulin requirements in women with type 1 diabetes (t1d). it aims to analyze differences in insulin needs and glucose levels, translating to changing levels of insulin sensitivities, between follicular and luteal phases using data from the tidepool data platform. key parameters include mean glucose, time in range (tir), and total insulin administration. secondary objectives involve assessing phase-specific glucose fluctuations, aggregated differences, and insulin adjustment strategies. the study follows a decentralized, anonymous data collection approach with participants using cgms and insulin pumps or smart pens. statistical analysis includes linear mixed-effects modeling to compare glycemic variability and changes in insulin sensitivity across cycle phases. the study also explores whether clusters of glycemic control and insulin sensitivity patterns can be identified among participants. findings aim to enhance our understanding of diabetes management during the menstrual cycle and potentially inform future treatment strategies.


Eligibility criteria:
inclusion criteria people are eligible to participate in the study if they: * are living with t1d; * are willing to upload diabetes-related data to the tidepool data platform; * are using a continuous glucose monitoring (cgm) system; * are using an insulin pump or a smart pen for most of their insulin delivery; * are willing to track and share their menstrual cycle data; * are 18 years old or older; * give consent to share their anonymized data for research.

Keywords: insulin sensitivity menstrual cycle diabetes management
efficacy and safety of meditoxin® in cervical dystonia

Conditions: Cervical Dystonia

Summary: the purpose of this study is to test the hypothesis that the efficacy and safety of meditoxin® are not inferior to botox®'s in the treatment of cervical dystonia.

the allocated subject is injected investigational product(meditoxin® or botox®) 200\~300u in cervical muscles. the efficacy and safety are evaluated for 12weeks through 4 follow up visits.

Eligibility criteria:
inclusion criteria: * men and women aged between 20 and 75. * patient who is diagnosed with primary cervical dystonia over 1 year. * patients whose total score is over 20 in twstrs and the severity score is over 10 in twstrs. * for patients with prior treatments of botox®, over 12 weeks have passed. * patients who voluntarily sign the informed consent * patients who can comply with the study procedures and visit schedule exclusion criteria: * patient who has been diagnosed with pure anterocollis. * patient who has been diagnosed with neuromuscular disorder(myasthenia gravis, eaton-lambert syndrome, amyotrophic lateral sclerosis, etc.)\\ * severe respiratory function disorder or dysphasia * allergy in investigational product. * pregnant women, breast feeding women and patients disagreeing to use an acceptable contraception method * investigator's decision.

Keywords: cd phase iii
mesna injection for tmj internal derangement

Conditions: TMJ Disorder

Summary: the pathogenesis of temporomandibular disorders focusing on the biochemistry of the synovial fluid in various stages of temporomandibular joint disease. the role of inflammation has been investigated and proposed as an underlying mechanism of pain and dysfunction of temporomandibular joint. mesna (sodium 2-mercaptoethanesulfonate) was approved several years ago and marketed in several formulations as a mucolytic agent in the respiratory field, since it breaks the disulfide bonds between polypeptide chains of mucus. the tissue distribution of mesna is negligible, and the elimination of the substance is rapidly and completely achieved by kidney


Eligibility criteria:
inclusion criteria: * patients with tmj internal derangement with reduction exclusion criteria: * inflammatory or connective tissue disease * autoimmune disease history * neurologic problems
very old intensive care patients - perfusion

Conditions: Microcirculation; Intensive Care; Very Old Intensive Care Patients

Summary: shock is a frequent, etiologically heterogeneous and often lethal clinical condition of intensive care medicine. this is particularly true for very old intensive care patients (vips), who are among the fastest-growing subgroups of all intensive care unit (icu) patients and who suffer from a significantly impaired outcome. in addition to the treatment of the causes of shock, current therapeutic approaches focus on the stabilization of vital parameters, which in general all reflect macrocirculatory measured values such as blood pressure. in contrast, a disturbance of the microcirculation (blood circulation of the smaller blood vessels \<100 µm) is only poorly measurable and delayed. the last generation of ava-software (microvisionmedical) will calculate different parameters about the capillary densitiv and perfusion in a user-independent way. vipper investigates whether a non-invasive measurement of microcirculation using the sublingual mucosa in very old intensive care patients in shock leads to faster recognition and specific treatment of organ dysfunctions. secondly, this study checks whether this measurement predicts outcome.


Eligibility criteria:
inclusion criteria: * ≥ 80 years * acute icu admission * shock at the time point of admission to the icu or in the first 3 hours defined as lactate ≥ 2 mmol/l and need for vasoactive substances to maintain a map ≥ 65 mmhg in the presence of adequate volume status exclusion criteria: * \< 80 years * inaccessibility for sublingual measurement * no informed consent

Keywords: microcirculation intensive care critical care shock very old intensive care patients risk stratification sdf-measurement
the conus brugada syndrome study

Conditions: Brugada Syndrome

Summary: an observational, analytical, cross sectional study investigating the effects of conus branch and right ventricular (rv) branch occlusion on surface ecg and intra-cardiac electrograms in patients undergoing percutaneous coronary intervention (pci).


Eligibility criteria:
inclusion criteria: * aged 18-85 * patients able and willing to give their written informed consent. * planned pci of a cto of a right coronary artery * planned use of an anchor balloon in the conus branch or rv branch exclusion criteria: * patients considered unsuitable to participate by the research team (e.g., due to medical reasons, laboratory abnormalities, or subject's unwillingness to comply with all study related procedures). * patients with a pre-existing, confirmed or possible diagnosis of brugada syndrome * marked st elevation or j point elevation on baseline (prior to procedure) ecg in the precordial leads (v1-v3) * pregnancy. this will be tested by urine hcg measurement
activation intervals effects on non-surgical maxillary expansion in adults

Conditions: Maxillary Anomaly

Summary: objective: to evaluate the effects of different time intervals activations on the non-surgical maxillary expansion in adults. methods: this study will include two groups, 10 adult patients each (mean age 20-35) with maxillary transverse deficiency and unilateral or bilateral crossbite. in the first group, the expansion is going to be activated every four days. in the second group, activation will occur every eight days. the primary outcomes are transverse dimension, the buccal cortical bone formation, and the upper premolar and molar labial inclination. dentoalveolar changes will be evaluated using cbct images and digital models.


Eligibility criteria:
inclusion criteria * presence of transverse maxillary deficiency unilateral or bilateral in which the maxillary cusps of at least two premolars and/or maxillary molars occluded on the central fossa of the antagonist's teeth * the needs of maxillary expansion for the correction of their malocclusion * age range from 20 to 35 * non-gingivitis or untreated caries at the start of orthodontic treatment * probing depth less than 4mm across the entire dentition * gingival index ≤ 1 * plaque index ≤ 1 exclusion criteria: * increased monson curve * patients with systemic disease * patients with congenital anomalies * medicated patients (long term use of antibiotics, phenytoin, cyclosporine, anti-inflammatory drugs, systemic corticosteroids, and calcium channel blockers) * pregnancy * poor oral hygiene for more than two visits * radiographic evidence of moderate to severe bone loss * current periodontal disease * patients who smoke * individuals with inadequately treated endodontic problems in the study area.

Keywords: palatal expansion technique cone-beam computed tomography
living well with chronic pain

Conditions: Chronic Pain, Widespread

Summary: the goal of this project is to test the effect of an interactive e-health intervention for people with chronic pain.

chronic pain conditions are common and difficult to cure. as much as 30% of adults in norway experience moderate-to-severe chronic pain, i.e., pain having lasted more than 3 months. chronic pain is also the most common cause of sick leave and disability pension in norway. despite a clear request from the authorities, e-health interventions for chronic pain has not yet been tested and implemented. the aim of this study is to investigate the effect of an interactive e-health intervention for people living with chronic pain, using outcome measures such as pain intensity, pain acceptance, anxiety/depression and quality of life. the e-health intervention will first be tested in a pilot study with 50 patients with different pain diagnoses and eventually in a randomized controlled trial with a sample of 240 patients with different pain diagnoses. the intervention will consist of one face-to-face introductory group followed by 9 app-based modules containing cognitive behavioral pain self-management material. the 9 modules will be distributed over minimum 27 days (minimum 3 days per module). the participants in the randomized controlled trial will be randomly assigned to use the e-health intervention or to a treatment as usual control group. both groups will receive outcome measures to complete at baseline and at 3, 6 and 12 months. post-rct, the epio study will also include a non-randomized group receiving the app-based epio program but without receiving an introduction session and follow up phone calls to examine potential benefits from receiving the app-based program only.

Eligibility criteria:
inclusion criteria: * chronic pain (pain \> 3 months) * \> 18 years of age * able to write/read/speak norwegian * have their own smart phone, pc or tablet exclusion criteria: * cancer related pain * migraine

Keywords: pain chronic pain self-management e-health appication app intervention cognitive behavioral therapy cbt acceptance and commitment therapy act psychological well-being
trans-vaginal aspiration of small ovarian endometrioma. comparison of two different techniques before icsi

Conditions: Ovarian Endometrioma

Summary: women candidate for icsi and having ovarian endometrioma smaller than 5 cm will be randomized to either transvaginal aspiration alone or transvaginal aspiration follwed by injection of small parts of oxidized regenerated cellulose within the cyst cavity during the cycle that preceded the induction cycle of icsi

women candidate for icsi and having ovarian endometrioma smaller than 5 cm will be randomized to either transvaginal aspiration alone or transvaginal aspiration follwed by injection of small parts of oxidized regenerated cellulose within the cyst cavity during the cycle that preceded the induction cycle of icsi. transvaginal aspiration will be done under ultrasonographic guidance with spinal needle insertion inside the cyst cavity followed by aspiration of the chocolate material from the cyst \& then irrigation of the cyst cavity with normal saline solution till complete elimination of the chocolate material. the needle will be withdrawn in women in non-surgicel group while injection of small pieces of surgicel inside the cyst cavity will be done for women in the surgicel group followed by withdrawal of the needle.

Eligibility criteria:
inclusion criteria: * subfertile women indicated for icsi * having a single endometrioma of less than 5 cm with typical sonographic criteria; a cyst with 1 to 4 locules and ground glass appearance of the cyst fluid with no papillary projections and no or minimal vascularization of the cyst capsule. since endometriotic cysts measuringmore than 1 cm are readily diagnosed by ultrasound,25 we chose a diameter of 2 cm as the lower limit to declare a cyst as endometrioma. * all cases had a normal uterine cavity demonstrated by ultrasonography and hysteroscopy. exclusion criteria: * bilateral or multiple endometriomas, lesions of more than 5 cm or showing atypical sonographic features presence of uterine pathology (eg, polyp or fibroid) * follicle-stimulating hormone (fsh) of more than 10, * body mass index of more than 30, age more than 40 years, * cases who received previous gnrh therapy for treatment of endometriosis within 12 months of the study * patients who received oral contraceptive pills or any form of hormones for the previous 3 months, * patients with previous surgical resection of endometrioma * severe male factor.
oral bacterial and viral mapping by dental plaque in elderly patients with and without alzheimer's disease(oral microbiology in alzheimer's patients)

Conditions: Periodontitis; Alzheimer Disease

Summary: the neurological disorders that accompany aging represent a major public health problem. the management of these diseases is a major medical and social priority. this project is based on the assumption that the oral cavity represents a privileged observation space to address these issues. the mouth is a site of easy access for painless sampling; there is therefore a major interest in identifying early oral infectious markers of the development or evolution of senile dementia. in addition to the interest of an early oral diagnosis, the mapping of the oral microbial flora in the demented elderly would allow a better understanding, prevention or even control of the evolution of neurodegenerative diseases. the final objective of our approach is to characterize the oral pathogens, or more probably the group of oral pathogens, which are significantly associated with alzheimer's disease.


Eligibility criteria:
inclusion criteria: * age greater than or equal to 70 years old * patient (or trusted person) having read and understood the study information note and signed the informed consent form * membership in a social security scheme * for cases : diagnosis of possible or probable alzheimer's disease according to the dsm-v exclusion criteria: * presence of a neurodegenerative pathology (excluding alzheimer's disease for cases) * presence of a neurocognitive disorder (excluding alzheimer's disease for the cases) * patient with or having had any kind of cancer, including oral or aerodigestive tract * patients with or having had autoimmune diseases (hiv, hepatitis) * patients with inflammatory diseases (such as rheumatoid arthritis (ra) or gougerot-sjogren's syndrome (gsj)) * patients with severe haemopathy * patients with severe acute or chronic cardiovascular, renal, hepatic, gastrointestinal, allergic, endocrine, pulmonary, neuropsychiatric pathologies, judged by the investigator to be incompatible with the study, as all these pathologies may interfere with the results of the oral flora sampling * patients who have undergone oral surgery in the two months prior to sampling * patients treated with oral retinoids, bisphosphonates, oral anticoagulants or anticonvulsants * patients who have had anti-cancer or immunosuppressive chemotherapy within the last 6 months * patient who has had antibiotic or anti-inflammatory treatment in the last 4 weeks * a history of treatments (drugs and probiotics) taken in the month prior to sampling will be taken, as well as a record of toxic habits (tobacco, alcohol, other)
curcuminoids and contrast-induced acute kidney injury

Conditions: Acute Kidney Injury; Contrast Media Toxicity; Curcuminoid; Chronic Kidney Diseases

Summary: the objective of this study was to evaluate the role of curcuminoids in the prevention of ci-aki in ckd patients.the result of the study was prophylactic administration with curcuminoids in addition to standard treatment reduce the incidence of ci-aki ckd patients undergoing elective cag.

this study was a single-center, prospective, double-blinded, randomized placebo-controlled trial in ckd patients undergoing elective coronary angiography (cag) at vajira hospital from october 2018 to march 2019. patients were stratified according to baseline estimate glomerular filtration rate (egfr) and diabetes status. they were randomized to curcuminoids 1,500 milligrams per day starting 3 days before and 2 days after coronary procedure or placebo. the primary outcome was the development of ci-aki, defined as serum creatinine rising ≥ 0.3 mg/dl within 48 hours after coronary angiography. the secondary outcomes were overall aki incidences within 7 days after cag, changes in egfr, il-6 hs-crp, and other adverse events. a total of 60 patients were enrolled( 30 in curcuminoids group, and 30 in the control group). overall aki developed in 5 patients in control group and none in curcuminoids group (16.67% versus 0%, p-value 0.052). the results showed that curcuminoids could preserve changes in egfr compared to the placebo group (-1.5 vs 2.5 ml/min/1.73m2, p-value \<0.001 within 48 hours and -4 versus 1 ml/min/1.73m2, p-value 0.002 within 7 days). the high-sensitive c-reactive protein (hs-crp) and il-6 levels were not different between patients receiving curcuminoids and placebo. in curcuminoids group, 3 patients developed mild nausea and diarrhea that improved with supportive care. no serious adverse events were found in both groups.

Eligibility criteria:
inclusion criteria: * all the patients undergoing elective cag at vajira hospital from october 2018 to march 2019 were included in the study * older than 18 years old * stable egfr 15-60 ml/min/1.73m2 in last 3 months. exclusion criteria: * dialysis-dependent * post-kidney transplantation * acute heart failure or critically ill * history of contrast or turmeric allergy * increasing of alanine aminotransferase (alt) or alkaline phosphatase (alp) more than three times of normal upper limits or post-cholecystectomy * history of aki (as evidence by scr change ≥ 0.3 mg/dl) within 14 days before the study - using medication included nsaids, warfarin, immunosuppression, n-acetyl cysteine, ascorbic acid or contrast agents within 14 days before the study * pregnancy or lactation o * denied consent .

Keywords: contrast-induced acute kidney injury curcuminoids coronary angiography