Kornimate/medical-research-clean huggingface dataset:
extended cancer education for longer-term survivors in primary care for patients with stage i-ii breast or prostate cancer or stage i-iii colorectal cancer

Conditions: Stage I Breast Cancer; Stage I Colorectal Cancer AJCC v6 and v7; Stage I Prostate Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage II Colorectal Cancer AJCC v7; Stage II Prostate Cancer; Stage IIA Breast Cancer; Stage IIA Colorectal Cancer AJCC v7; Stage IIA Prostate Cancer; Stage IIB Breast Cancer; Stage IIB Colorectal Cancer AJCC v7; Stage IIB Prostate Cancer; Stage IIC Colorectal Cancer AJCC v7; Stage III Colorectal Cancer AJCC v7; Stage IIIA Colorectal Cancer AJCC v7; Stage IIIB Colorectal Cancer AJCC v7; Stage IIIC Colorectal Cancer AJCC v7

Summary: this study tests four different methods of educating patients about follow-up care (nci facing forward, brochure, excels website alone, excels health coaching alone and excels website \& health coaching combination) after cancer treatment ends. while it is known that patients need information to guide follow-up it remains unknown how to best provide this in primary care.

primary objectives: i. develop the excels intervention to facilitate engaged self-management of cancer follow-up for cancer survivors. ii. evaluate the efficacy of excels intervention in a small randomized controlled trial. iii. assess/refine intervention usability and acceptability for primary care patients. outline: phase i: excels intervention is developed and assessed. phase ii: participants are randomized into 1 of 4 arms. arm i: participants receive national cancer institute's facing forward brochure. arm ii: participants have untimed access to the excels mobile web application. arm iii: participants also receive 4 calls of 15-20 minutes each over 3 months focusing on assisting survivors with addressing challenges to receiving preventive service and health care. arm iv: participants have access to excels website as in arm ii. participants also receive 4 health coaching calls as in arm iii. patients are followed up at 6 months, 12 months and 18 months post randomization.

Eligibility criteria:
inclusion criteria: * have been diagnosed with localized breast or prostate (stages 1-2) or colorectal cancer (stage 1-3) * have completed active treatment for their cancer diagnosis (excluding hormonal therapy) * have access to a phone for contact with health coach * be able to communicate in english; and be competent to consent * usability testing and the randomized control trial (rct): have access to a computer, a smartphone or an i-pad/tablet equivalent with internet access exclusion criteria: * patients who are required because of their disease to see primarily oncologists for follow-up will be excluded (i.e., those diagnosed with lymph node or distant metastasis, those with a new primary cancer)
comparative evaluation between the effectiveness of vibration assisted syringe and conventional syringe

Conditions: Anxiety, Dental

Summary: the study will be conducted to evaluate the effect of the vibration assisted syringe on pain perception and anxiety in children during intra oral injection of local anesthesia in comparison with conventional syringe.

as for granted the main concern in pediatric dentistry is to guarantee a positive response from child for any further appointments, that's why we aim to manage a successful dental procedure keeping a stress free situation. conventional local anesthetic technique is the most commonly used technique for anesthetizing teeth but in turn it has shown the highest levels of discomfort in comparison with other techniques. vibraject is vibration associated syringe device, it is simple and cost effective solution to alleviate injection discomfort. it works because the light pressure of a vibraject injection is carried rapidly to the brain by thicker insulated nerve tissues. in contrast, the needle prick travels on thinner nerve tissues, arriving too late for the brain to register the sensation. vibraject is good news for the patient, because the anesthetic itself causes virtually no discomfort and good news for the dentist, who can work easily knowing that patient, is comfortable.

Eligibility criteria:
inclusion criteria 1. cooperative patient. (rating 4 or 3 based on frankl behavior scale). 2. children aging from 4 to 6 years 3. suffering from one or more deep carious lesions in their primary molars. 4. restorable primary molars exclusion criteria: 1. medically compromised patients. 2. uncooperative children (rating 1 or 2 on the frankl behavior scale) needing special line of treatment through general anesthesia. 3. signs and symptoms of irreversible pulpitis, spontaneous pain, necrosis or any signs and symptoms of abscess. 4. presence of any radiographic signs of abscess, bone loss, internal or external root resorption.
optimizing expectations in cardiac surgery patients

Conditions: Coronary Artery Bypass Graft Surgery (CABG); Patients' Expectations; Coronary Heart Disease

Summary: the purpose of this study is to evaluate the potential benefit of targeting patients' expectations before coronary artery bypass graft surgery through a brief psychoeducational intervention.

coronary artery bypass graft surgery (cabg) is an extremely invasive medical intervention.it is postulated that even under these conditions, treatment outcome is substantially determined by non-specific effects, e.g. patient's expectation. targeting patients' expectations at an early stage might have potential to optimize outcomes after cardiac surgery. the purpose of this research project is to optimize patients' outcome expectations before undergoing cardiac surgery through a brief psycho-educational program. using a randomized controlled design, 180 patients who are scheduled to undergo elective cabg are randomly assigned either to standard medical information alone, or to an additional expectation manipulation intervention (emi) during the two weeks before surgery, or to an attention-control group ("supportive therapy"). the main goal is to enhance positive expectations (surgery 'non-specific effects') about favorable outcome through emi, about coping abilities to deal with adverse events, and to reduce negative expectations and misconceptions. assessment takes place before and after emi, 10 days after surgery and 6 months later; same assessment points are used for the 2 control conditions. primary outcome is disability, which has been shown to be strongly determined by patient's expectation in previous studies. moreover, psychological and biological predictors and mediators of treatment success are analyzed. a positive result for this expectation intervention would have major implications for clinical practice. in order to optimize treatment outcome, it is not only necessary to improve the treatment-specific procedures (e.g., cardiac surgery) but also to address non-specific factors such as patients' expectations.

Eligibility criteria:
inclusion criteria: * patients scheduled on the elective waiting list for first time coronary artery bypass graft surgery wiht the use of heart-lung-apparatus at the department of cardiovascular surgery, medical school, university of marburg * sufficient knowledge of german language * ability to give informed consent exclusion criteria: * emergency surgery * presence of a serious comorbid psychiatric condition * presence of a life threatening comorbid medical condition * current participation in other research

Keywords: coronary artery bypass graft surgery (cabg) patients' expectations coronary heart disease illness perception intervention randomized controlled trial
corneal elastography and patient specific modeling

Conditions: Cornea; Ectasia; Refractive Errors; Keratoconus

Summary: the goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. patients who either 1) have keratoconus and are being evaluated for corneal crosslinking or 2) have refractive error and are being evaluated for refractive surgery procedures such as lasik will have their eyes imaged to assess their mechanical properties and will have computational simulations performed to predict the response to treatment. one aim of the study is to test the hypothesis that computational models can predict the cornea's shape changes within clinically acceptable limits of error.

the mechanical condition of the cornea is an important but elusive property of the eye to characterize. weakness in the cornea is thought to be one of the primary causes of corneal ectasia, a major cause of visual impairment worldwide. corneal weakness is also important to identify in refractive surgery candidates since such surgeries often involve tissue removal that could lead to corneal instability in certain predisposed patients. in this study, subjects will undergo imaging with an optical coherence tomography (oct)-based system to characterize corneal biomechanical properties. in addition, computational representations of the eye will be built from images and interventions will be simulated and compared to actual treatment outcomes. no investigational procedures or study-specific interventions other than imaging are involved.

Eligibility criteria:
inclusion criteria: * any patient with keratoconus diagnosed by standard criteria, including topographic steepness, irregular astigmatism with a pattern consistent with keratoconus. * any patient deemed a candidate for lasik (laser vision correction) and scheduled for surgery. exclusion criteria: * inability to provide informed consent, including non-english speaking (if interpreter not available) and cognitively/mentally impaired (if legal guardian not available).
environmental assessment of sleep in youth

Conditions: Sleep Disorders in Children; Environmental Exposure

Summary: in this research study, investigators want to learn more about the factors that influence children's breathing during sleep and their sleep quality. specifically, investigators are interested in factors that are related to risk of snoring, sleep apnea (a condition where breathing stops during sleep), and poor sleep quality.

investigators are doing a research study to gather information to help better understand why snoring and sleep problems are so common in the community, and how the home and neighborhood environment impacts sleep in children. investigators want to know if factors such as the quality of air, household dust, environmental noise, and family routines impact sleep and other health and behavioral factors associated with sleep. investigators want to test how sleep is influenced by factors such as: the quality of air inside and outside the child's home (including measuring pollution, second hand smoke, and dust); temperature and humidity; family routines and interactions; and characteristics of the home. investigators will ask participants to come in for a one time visit for undergoing procedures as well as answering questions regarding general health, asthma and sleep. 10% of the participating children will have a second home assessment and sleep monitoring procedures performed 6 months after the initial home assessment.

Eligibility criteria:
inclusion criteria: * age 6-12 years * children living (50% of the time or more) at their current residence for at least 1 month exclusion criteria: * children with severe chronic diseases (e.g. cancer, genetic or congenital disorders interfering with mobility) * children with severe neurobehavioral, neurodevelopmental or psychiatric disorders requiring special assistance * children living in the current residence for \< 1 month will be not be eligible. * families who do not speak english or spanish well enough to complete the neuropsychological measures, as validated versions in other languages are not available for all of the measures.

Keywords: sleep sleep in children children and sleep environment environment and sleep environment and children
evaluation of the h.o.o.v.e.s. healing intensives program

Conditions: Anxiety; PTSD; Depression

Summary: the aim of this study is to measure the impact of these h.o.o.v.e.s. healing intensives on veteran participants using several psychological instruments. the investigators are planning to administer the demographic questionnaires and psychological instruments to veteran participants before the healing intensives. psychological instruments will be administered immediately pre-intervention, pre- and post-session for each session, post-intervention, 90, 120 and 360 days post-intervention. the primary aim is to assess for statistically significant changes pre- to post session and pre- to post-intervention.


Eligibility criteria:
inclusion criteria: * veterans who have served in the military * must be enrolled in a h.o.o.v.e.s. healing intensives program * english speakers

Keywords: horses anxiety ptsd depression
use of ha 330-ii for hemofiltration in patients with alf as a bridge to liver transplantation .

Conditions: Acute-On-Chronic Liver Failure

Summary: alf (alf) is defined by three criteria: (1) rapid development of hepatocellular dysfunction (jaundice, coagulopathy), (2) hepatic encephalopathy, and (3) absence of a prior history of liver disease. interval between onset of acute hepatic injury (jaundice) and onset of liver failure (encephalopathy with or without coagulopathy) in such patients (icterus-encephalopathy interval; iei) has been described to be between 4 weeks (indian definition) to 24 weeks (aasld-alf study group). further, due to the diverse natural course, alf has been sub-classified as hyperacute (iei ≤ 7 day), acute (iei ≤ 4 weeks) and sub-acute alf (iei ≥ 5 week to ≤12 weeks) by british authors.

since the 1960s, liver transplantation (lt) has emerged as a cornerstone intervention to cure liver failure. mortality in patients with liver failure who cannot be rescued with liver transplantation remains high despite improvements in supportive care. artificial liver support system (alss) in alf aim to remove excess inflammatory cytokines and attenuate inflammatory response, to remove albumin-bound and water-soluble toxins, to restore and preserve hepatic function and mitigate or limit the progression of multiorgan failure while hepatic recovery or liver transplant occurs. alss may also provide benefit in instances where lt is contraindicated. the following beneficial effects have been documented with alss in alf patients: improvement of jaundice, amelioration of hemodynamic instability, improvement of hepatic encephalopathy, sofa score and survival. ha 330-ii is a broad-spectrum adsorbent made of neutral macroporous resin, removes toxins such as inflammatory mediators (il-1, il-6, il-8 \& tnf-α) along with hepatic toxins such as phenol, mercaptan, aromatic amino acids, false neurotransmitters and indirectly ammonia by improving liver function recovery. however, this indirect ammonia removal with ha 330-ii is insignificant. by removing excess inflammatory cytokines and attenuating uncontrolled immune response, ha 330-ii prevents worsening of encephalopathy, improves liver function recovery and improves prognosis.

Eligibility criteria:
inclusion criteria: • acute liver failure patients with sirs and hepatic encephalopathy, without hyperbilirubinemia. exclusion criteria: * patients with age less than 18 years or more than 65 years * extremely moribund patients with an expected life expectancy of less than 24 hours or with poor prognosis * with poor blood clotting function and pta \<30%. * active bleed * chronic heart, lung or kidney disease * malignant tumors including liver cancer * past history of organ transplantation
does serum-dxm increase diagnostic accuracy of the overnight dxm suppression test in the work-up of cushing's syndrome?

Conditions: Cushing's Syndrome; Adrenal Incidentalomas; Alcoholism; Obesity

Summary: background: the evaluation for hypercortisolism includes an overnight 1mg dexamethasone (dxm) suppression test. an important shortcoming is the diagnostic specificity of only 80%, which is likely due to inter-individual differences in gut absorption or metabolism of dxm. study hypothesis: the investigators hypothesize that serum-dxm measurements will increase the diagnostic accuracy of the overnight dxm-test in the work-up of hypercortisolism. aims: the primary aim of this prospective study is to evaluate if serum-dxm measured simultaneously with serum-cortisol in morning samples could increase the diagnostic accuracy this diagnostic test. there are several secondary aims. one is to estimate the prevalence and causes of unusual dxm absorption or metabolism. the investigators will also evaluate the feasibility and diagnostic accuracy of salivary dxm. moreover, the diagnostic accuracy of midnight salivary cortisol and cortisone, and urinary cortisol, will be evaluated and compared. design: levels of dxm in morning serum following an overnight dxm-test will be analyzed in patients under evaluation for hypercortisolism (including incidentalomas). a cut-off level to identify inadequate dxm concentrations in serum to suppress endogenous cortisol production will be established based on the negative tests. this cut-off level will then be applied in a retrospective analysis of the diagnostic accuracy of dxm-tests. this prospective study has a blinded design as the dxm measurements are disclosed after the end of the trial.


Eligibility criteria:
inclusion criteria: * age over 18 years * under investigation for hypercortisolism * able and willing to make informed consent exclusion criteria: * use of systemic or local glucocorticoids

Keywords: hypercortisolism, dexamethasone, alcoholism,obesity.
headache inducing effect of cromakalim in migraine patients

Conditions: Headache, Migraine

Summary: to investigate the role of katp channels on the cerebral hemodynamic in migraine patients.


Eligibility criteria:
inclusion criteria: * migraine patients of both sexes. * 18-60 years. * 50-90 kg. * women of childbearing potential must use adequate contraception. exclusion criteria: * headache less than 48 hours before the tests start * daily consumption of drugs of any kind other than oral contraceptives * pregnant or nursing women. * cardiovascular disease of any kind, including cerebrovascular diseases.

Keywords: levcromakalim
rehabilitation of stroke patients for maximal neurological restoration

Conditions: Stroke

Summary: multimodal imaging of stroke patients. patients included in the study will be investigated with multiparametric imaging tools including mri and eeg imaging. improvements in motor skills will be monitored clinically.

we aim to (i) quantify the size of the brain lesion and assess the surviving functional neural network connections; (ii) analyze the type and degree of inflammation initiated by the stroke-induced brain lesion. we will stratify inflammation according to lesion volume, surviving functional neural network connections, age, nihss and modified rankin scale (mrs) and analyze how inflammation markers change during rehabilitation; (iii) train the surviving neural network to create new synaptic connections that can maximize restoration of motor functions; (iv) apply and develop advanced mathematical and computational methods to model and predict how stroke rehabilitation can rewire the neural network connections to best facilitate restoration of lost motor function.

Eligibility criteria:
inclusion criteria: * subcortical strokes resulting in arm motor deficits. * admitted to the stroke unit, st olav´s hospital during 2021-2023 exclusion criteria: * previous stroke * neurodegenerative disease * brain tumors * previous neurotrauma or brain operation * aphasia * cognitive dysfunction and claustrophobia preventing mri examinations.

Keywords: rehabilitation
eeva™ pregnancy pilot study (pps)

Conditions: Infertility

Summary: the purpose of this clinical investigation is to gather pilot data to evaluate the impact of using eeva™, a time-lapse enabled embryo test, in combination with traditional morphology on clinical pregnancy rates.


Eligibility criteria:
inclusion criteria: * women undergoing fresh in vitro fertilization treatment using their own eggs * ≤ 40 years * ≥ 4 diploid embryos (i.e. having 2 pns) * ≤ 3 prior art cycles (ivf, icsi and related procedures) * all 2pn embryos (for all 3 arms) must be imaged by eeva * subject willing to comply with study protocol and procedures * subject willing to provide written informed consent exclusion criteria: * preimplantation genetic diagnosis or preimplantation genetic screening * planned "freeze all" cycle (eggs or embryos) * asherman's syndrome * donor egg * gestational carrier * presence of hydrosalpinx on ultrasound * concurrent participation in an interventional clinical study

Keywords: in vitro fertilization
whey protein ingestion and glucose control in pre- and post diabetic individuals

Conditions: Prediabetes / Type 2 Diabetes

Summary: to examine the effects of twice daily whey protein consumption on blood glucose and insulin in pre-diabetic and diabetic individuals

protein consumption in the morning has been shown to reduce appetite and caloric intake (19). in addition, premeal whey consumption reduces post prandial blood glucose, reduces gastric emptying rate, and increases peak blood insulin (10). thus, it is proposed that ingestion of whey protein within 1hr of waking (and prior to breakfast) and 30 minutes prior to dinner will be more effective in suppressing appetite, carbohydrate intake, and glucose auc. ingestion upon waking will mitigate the cortisol-induced drive for carbohydrate intake. ingestion prior to dinner, the most frequently consumed and largest meal in america (20), will reduce food intake, post meal blood glucose, and insulin area under the curve (21). specific aims 1. determine the effect of wp ingestion within 1hr of waking and prior to breakfast, and 30min prior to dinner, on appetite suppression, carbohydrate and caloric intake, and 24hr glucose auc over 7d in pre-diabetic (a1c 5.7%-6.4%) and diabetic (a1c 6.5%-7.5%) individuals. 2. determine the effect of wp ingestion within 1hr of waking and 30min prior to dinner on changes in ogtt, matsuda index, and whole-body protein balance (compared to control) before and after 7d of wp consumption in pre-diabetic and diabetic individuals. 3. determine outcome differences between pre-diabetic and diabetic individuals.

Eligibility criteria:
inclusion criteria: 1. males and females ages 50-70 years. 2. capable of providing informed consent. 3. covid-19 negative and/or asymptomatic. 4. willing to abstain from drinking alcohol or consuming marijuana and cbd products during the 7-day study meal period on two occasions. 5. hba1c: 5.7-6.4% or 6.5% to 7.5% exclusion criteria: 1. subject who does not/will not eat dairy protein sources. 2. subjects taking exogenous insulin injections or glp /gip injections or other appetite suppressants. 3. unwilling to keep a detailed 7 day food journal on two occasions 4. unwilling to wear a cgm for 7 days on two occasions and share the data with the research team. 5. lactose intolerance. 6. hemoglobin \<10g/dl at screening. 7. history of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment. 8. history of gastrointestinal bypass/reduction surgery. 9. pregnant or lactating individuals. 10. history of a chronic inflammatory disease (e.g. lupus, crohn's disease) 11. currently receiving androgen (e.g., testosterone) or anabolic (e.g., gh, igf-i) therapy. 12. currently using corticosteroid medications (cortisone, hydrocortisone, prednisone, etc.). 13. unwilling to avoid using protein or amino-acid supplements during participation. 14. unwilling to fast overnight. 15. any medical condition or medication that the pi or clinical study staff finds contradictory to this study.

Keywords: whey protein type ii diabetes protein turnover dietary intake