Kornimate/medical-research-clean huggingface dataset:
epidural morphine following vaginal delivery

Conditions: Pain

Summary: the investigators believe that pain management following a vaginal delivery can be improved. many women receive epidural medication during labor and delivery, and the investigators felt that using the epidural following delivery might improve the first day pain. this study is to determine whether a single dose of epidural morphine given to mothers after a vaginal delivery will reduce the perineal pain in the postpartum period.

vaginal deliveries comprise 80-85% of all deliveries. although this is felt to be natural and safe, this route can be associated with significant perineal trauma and subsequent postpartum perineal pain. the degree of perineal trauma varies from the minimum of vaginal stretching and distension associated with labor, to episiotomy and significant perineal tears. in spite of the differences in the degree of injury following vaginal delivery, postpartum pain therapy is poorly organized and at best consists of simple analgesics and anti-inflammatory drugs. the purpose of this study is to determine if a single dose of epidural-administered morphine offers additional advantage to an organized program for the management of immediate postpartum perineal pain following vaginal delivery.

Eligibility criteria:
inclusion criteria: * healthy parturients (asa 1 or 2) of \> 34 weeks gestational age who chose epidural analgesia for labor, and deliver vaginally. exclusion criteria: * women whose labor is terminated by cesarean delivery * parturients with known morphine allergy * parturients with narcotic addiction past / present

Keywords: postpartum perineal pain epidural morphine randomised clinical trial
direct factor xa inhibitor ym150 for prevention of stroke in subjects with non-valvular atrial fibrillation

Conditions: Atrial Fibrillation

Summary: to evaluate the safety and tolerability of ym150 in subjects with non-valvular atrial fibrillation (nvaf)and to obtain information on pharmacokinetics and pharmacodynamics (anti-thrombotic potential) in the target population


Eligibility criteria:
inclusion criteria: subjects are eligible for the study if all of the following apply: * subject has paroxysmal permanent or persistent nvaf * subject has inr of 2.0 or below and an aptt ≤ 1.5 times the upper limit of normal at the baseline visit. * legal minimum age requirement (country-specific). * written informed consent has been obtained. exclusion criteria: * history of heart valve disorders * history of rheumatic fever. * history of stroke and/or systemic embolism (including tia). * history of acute coronary syndrome (acs). * indication for warfarin other than nvaf. * known hemorrhagic disorder and/or coagulation disorder. * active bleeding or any condition associated with increased risk of bleeding.

Keywords: factor xa inhibitor atrial fibrillation stroke ischemic attack thromboembolism prevention and control
early detection of skin cancer with sensor technology

Conditions: Carcinoma, Basal Cell

Summary: skin cancer represents a large problem in today's healthcare setting. the majority of cancer diagnoses are attributed to malignant skin diseases including its major types: basal cell carcinoma, squamous cell carcinoma and melanoma. early diagnoses is critical given early detection of malignant lesions largely increases chances of successful treatment. the current gold standard of diagnosis is histopathological examination of biopsied skin. biopsies are not only invasive and expensive, they have variable positive predictive value, meaning they may often be preformed unnecessarily. as such, the investigators have developed a skin scanner, which is less bulky and expensive than existing similar technologies, as a tool to evaluate skin lesions prior to determining the need for a biopsy. their objective is to obtain information in order to validate this skin scanner in the context of its ability to accurately identify basal cell carcinoma skin lesions.


Eligibility criteria:
inclusion criteria: * patient requiring skin biopsy for suspected basal cell carcinoma skin lesion * 18 years of age or older exclusion criteria: -poor english fluency, pregnancy

Keywords: detection
analyses of cerebrospinalfluid in patients with delirium

Conditions: Delirium

Summary: the current project aims to measure biomarkers in the cerebrospinalfluid (csf) and serum samples from patients with delirium. we hope to uncover new insights into the pathophysiology of delirium and explore its link to dementia.

delirium is a common and serious complication to acute illness, and is characterized by acute disturbances in attention, awareness, and cognition. dementia is a major risk factor of delirium, and delirium increases the risk of dementia progression and development. as the conditions share both clinical and epidemiological features, some researchers suggest that also pathophysiological links are shared. understanding delirium pathophysiology, which is poorly understood, may thus help elucidate early molecular mechanisms in dementia. this study aims to to increase our understanding of the pathophysiology of delirium and molecular links between delirium and dementia, by exploring cerebrospinal fluid (csf) biomarkers.

Eligibility criteria:
inclusion criteria: * patients with acute hip fracture exclusion criteria: * moribund patients. * lack of consent
effect of escalating doses of a novel viscous polysaccharide on postprandial glycemia

Conditions: Blood Glucose, Postprandial

Summary: to determine palatability and extent to which escalating doses of a novel highly viscous polysaccharide \[nvp\] reduces postprandial glycemia when added to a liquid and a solid meal.


Eligibility criteria:
inclusion criteria: * healthy individuals * 18-75 years old * bmi less than 35 kg/m2 exclusion criteria: * medications influencing gastrointestinal function * pregnancy

Keywords: viscous fibre polysaccharide blood glucose post prandial
prehabilitation rectal cancer during adjuvancy vs before surgery

Conditions: Colo-rectal Cancer

Summary: preoperative preparation protocol (prehabilitation) for patients diagnosed with colorectal cancer who need surgery. it consists of a change in the preoperative preparation. the patient is an active part of their preparation and the professionals help to achieve a better functional capacity to diminish morbidity and accelerate recovery. three levels are controlled: * physical: control and stimulation to exercise at home. * nutrition: control and advice through homemade recipes. * emotional: control of the level of haste or depression and advice of mindfullness techniques at home. if they need specific help they are derived from specialized professionals (rehabilitator, nutritionist / endocrinologist, psychologist).

protocol for colorectal neoplasia patients who need surgery by modifying the current one. until now, in the preoperative time, the anesthetist evaluated the need for some specific action such as pre-operative iron administration to avoid perioperative transfusions or the need to assess some of the patient's morbidities to try to optimize it. in the perioperative period in our hospital, the criteria of the multimodal and fast-tcack rehabilitation programs have been applied for a long time and there are some trajectories that allow standardization of patient management once they have been admitted. it is demonstrated in other centers and in other surgical pathologies that, in addition to what we are already applying to our center, modify the preoperative preparation of our patients and try to improve their "functional capacity" results of lower morbidity and mortality and the subsequent recovery of patients can greatly improve . this is called prehabilitation. pretreatment consists in a change in preoperative preparation at three levels. the concept of preoperative preparation changes and the patient is actively involved in it. three levels of the patient are controlled: functional or physical level, nutritional level and emotional level, by means of pots and they are encouraged to make a series of changes in their habitual life (exercise, dietary advice, mindfullness techniques) that increase its functional capacity. this is related to a decrease in morbidity and mortality and in addition to a better and faster postoperative recovery.

Eligibility criteria:
inclusion criteria: * patient diagnosed with colorectal neoplasia * need colorectal surgery with curative indication * scheduled surgery exclusion criteria: * patients who refuse to enter the study * patients with indication of palliative surgery * surgeries that involve colon and other organs * urgent surgery * basic pathology that does not allow to carry out some of the explorations necessary to carry out the trimodal pre-treatment.

Keywords: colon cancer, rectal cancer, prehabilitation
nola gem: feasibility and acceptability of an mhealth intervention for violence-affected plwh

Conditions: HIV; Mental Health; Substance Use

Summary: the objective of the proposed research is to conduct formative work to develop, pilot and refine a smartphone delivered intervention for violence affected people living with hiv utilizing a novel spatial-temporal methodology, geographical ecological momentary assessment (gema), to first identify the activity spaces and daily psychosocial experiences (mental health symptoms, substance use, self-efficacy, coping) impacting adherence and viral suppression, and apply them to intervention. guided by an ecological perspective, the investigators will adapt living in the face of trauma to a mobile platform with gema informed intervention targets. the resulting app shall be referred to as nola gem. our long-term goal is delivering accessible interventions informed by daily experiences that affect health for plwh. the investigators will test feasibility, acceptability and preliminary efficacy of the gema-informed nola gem app against gema alone on adherence and care, and secondary outcomes of mental health and substance use.


Eligibility criteria:
inclusion criteria: * having a reported hiv infection and being on art. exclusion criteria: -

Keywords: adherence mhealth care engagement
noise exposure and near-infrared light

Conditions: Hearing Loss, Noise-Induced

Summary: the primary objective of this work is to determine the effect noise has on the auditory system (both auditory health and performance) and also the degree to which the effect of pre-noise therapy such as near infrared (nir) light can mitigate the effects of noise exposure.


Eligibility criteria:
inclusion criteria: * 18-45 years old, male or female * pass hearing exam with a threshold of 25 decibels (db) hearing or less, for each ear, for all frequencies tested from 500 hz to 8000 hz * normal otoscopic exam, otoacoustic emissions (oaes), and middle ear function as demonstrated by a normal tympanogram * completion of a hearing history questionnaire exclusion criteria: * screening hearing test failure * pregnant females * adults unable to provide consent * history of significant ear surgery

Keywords: noise induced hearing loss near infrared energy hering test
detection of functioning pituitary microadenoma: pet/mri versus pet/ct

Conditions: Pituitary Adenoma

Summary: this is a prospective case-control study to compare the usefulness of 18f-fdg pet/mri with that of 18f-fdg pet/ct in detection of functioning pituitary microadenomas.a single dose of 370 mega-becquerel (mbq) 18f-fdg will be injected intravenously.visual and semiquantitative method will be used to assess the pet/mri and pet/ct images.

magnetic resonance imaging (mri) may be insufficient to locate functioning pituitary microadenoma.this study compared the usefulness of 18f-fdg pet/mri with that of 18f-fdg pet/ct in detection of functioning pituitary microadenomas in patients with inconclusive conventional mri findings. trans-sphenoidal adenomectomy was performed within 2 weeks of imaging.the pet/ct and pet/mri findings and tracer uptake levels were correlated with the surgical findings and pathological results.

Eligibility criteria:
inclusion criteria: * patients who were pathologically diagnosed with pituitary adenoma after surgery were recruited, and were able to provide basic information and sign the written informed consent form. exclusion criteria: * the exclusion criteria included claustrophobia, kidney or liver failure, and inability to fulfill the study.
muscle activation characteristics during spinal manipulation in healthy and low back pain participants

Conditions: Back Pain

Summary: to characterize muscle activity through electromyography (emg) of the lumbar spine during high velocity, low amplitude (hvla) spinal manipulation according to parameters of practitioner contact (location, applied force) in healthy participants and two categories of low back pain participants.


Eligibility criteria:
inclusion criteria: * male and female participants ages 18 to 55 years old exclusion criteria: active worker's compensation claim related to low back pain episode active personal injury case related to low back pain episode currently taking muscle relaxers, steroids, or narcotics * body mass index \> 30 kg/m2 * active cancer process * active infection * pregnancy * high risk of osteoporosis assessed using the world health organization fracture risk assessment tool (included in submission) * osteogenic conditions (see screening questionnaire) * premature menopause * latex allergies * lumbar spine or pelvic surgery * past spinal trauma producing spinal fracture

Keywords: manipulation spinal electromyography kinetics kinematic
upper extremity asymmetries in overhead athletes

Conditions: Extremity Asymmetries; Injury;Sports; Performance

Summary: although overhead sports have different characteristics, the movements in the shoulder and upper extremity are similar. these sports may involve a combination of symmetrical, asymmetrical, bilateral and unilateral movements. in sports involving asymmetric movements, biomechanical changes are observed in that area due to the use of the dominant extremity. one of the reliable methods to reveal the stress effects caused by biomechanical stresses is to determine limb asymmetries. considering the literature, limb asymmetries may be related to injury and performance.


Eligibility criteria:
inclusion criteria: * 15 years and older * attending regular sports training and competitions exclusion criteria: * acute injury during tests

Keywords: asymmetry injury performance overhead
transcranial electrical stimulation (tes) for the treatment of depression.

Conditions: Major Depression

Summary: this study is a rct of transcranial electrical stimulation in depressed patients. mood, cognitive test performance and biomarkers will be measured during the trial.


Eligibility criteria:
inclusion criteria: * dsm-iv major depressive episode (as part of a major depressive disorder or bipolar disorder), of minimum 4 weeks duration. * madrs score ≥ 20 at study entry. exclusion criteria: * dsm-iv psychotic disorder; * drug or alcohol abuse or dependence (preceding 12 months); * inadequate response to ect (current episode of depression); * anticonvulsant or benzodiazepine medication; * rapid clinical response required, e.g. high suicide risk; clinically defined neurological disorder or insult; * metal in the cranium, skull defects, or skin lesions on scalp (cuts, abrasions, rash) at proposed electrode sites; * pregnancy.
safety of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for testicular injury and oligospermia

Conditions: Testicular Injury; Oligospermia

Summary: this trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of testicular injury and oligospermia

this patient funded trial aims to study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells (uc-mscs) for the treatment of testicular injury and oligospermia. patients will receive a single intravenous infusion of uc-mscs. the total dose will be 100 million cells. patients will be evaluated within one month pre treatment and at 1, 6, 12, 24, 36, and 48 months post treatment for safety and efficacy. for patients with more severe disease an autologous effector cells (activated lymphocytes) treatment will be utilized created from the patient's own cells obtained by apheresis.

Eligibility criteria:
inclusion criteria: * diagnosis of testicular injury or oligospermia * understanding and willingness to sign a written informed consent document exclusion criteria: * active infection * active cancer * chronic multisystem organ failure * clinically significant abnormalities on pre-treatment laboratory evaluation * medical condition that would (based on the opinion of the investigator) compromise patient's safety. * continued drug abuse * previous organ transplant * hypersensitivity to sulfur

Keywords: oligospermia testicular injury stem cell treatment
the reliable nutritional risk screening tools

Conditions: Malnutrition, Child

Summary: * assess the subjective global validity and reliability of using the pediatric yorkhil malnutrition score (pyms) and merits of using the screening tool for risk on nutritional status and growth (strongkids) as a nutrition screening tool * correlate it with the severity of their nutritional derangements in comparison to the screening tool for the assessment of malnutrition in pediatrics (stamp)in hospitalized egyptian children aged (2-5)years in assiut university children hospital (auch).

malnutrition is responsible for around 3.1 million child deaths annually in low and middle income countries,the malnutrition is involved in about 45% of under-five children deaths in numerous developing countries. malnutrition is associated with negative outcomes for inpatients, including increased risks of infections , increased muscle loss , impaired wound healing, longer hospital stay and increased morbidity and mortality . malnutrition may be responsible for delayed recovery and need for intensive nursing care, thus increasing the cost of hospitalization . nutritional support for inpatients has made progress and it is provided systematically through multidisciplinary nutritional support teams (nsts) in most hospitals. the first step to run and manage the nst effectively and efficiently in each hospital may be proper screening and selection of the patients who are at risk of malnutrition requiring nutritional support during hospitalization routine nutritional screening is rarely carried out in pediatric patients because of the lack of a simple and properly validated nutritional screening tool. the current practice of identifying children at risk of malnutrition is reliant on interpretation of anthropometric data and clinical judgement; the reliability of which is dependent on nutritional knowledge of pediatricians . severe cases of malnutrition are easily recognized; however, the identification of children with lesser degrees of malnutrition or at risk of malnutrition, which is also important, is not as easily achieved.

Eligibility criteria:
inclusion criteria: * all patients at the age of 2-5 years admitted in assiut university children's hospital exclusion criteria: * no
functional microscale organotypic assays to predict patient response to anti-angiogenesis therapies

Conditions: Renal Cell Carcinoma

Summary: the primary objective of this research is to evaluate response to systemic therapy, including anti-angiogenesis therapy and/or immune-based therapies via 18f-dcfpyl prostate-specific membrane antigen (psma)-based positron emission tomography/computed tomography (pet/ct) in patients with metastatic renal cell carcinoma (rcc) and to compare qualitatively with conventional imaging response criteria - response evaluation criteria in solid tumors (recist 1.1) and histopathological endpoints including isolation, enumeration and staining of circulating tumor cells (ctc).

response of systemic therapy, including anti-angiogenesis therapy and/or immune-based therapies will be quantified using psma-based pet imaging using a novel agent,18f-dcfpyl, as a non-invasive imaging biomarker of tumor neovasculature to functionally monitor renal cell cancer neovasculature in patients undergoing systemic anti-angiogenesis therapy. psma pet will be compared with response to anti-angiogenesis therapy using conventional imaging computed tomography(ct)-based recist1.1 criteria as well as histopathological endpoints (tumor vascular density, immunohistochemical staining for psma and neovascularization (cluster of differentiation(cd)105, cd31). whole body psma pet/ct scans will be obtained at baseline, following adjuvant anti- angiogenic therapy and when the patient becomes refractory to treatment. the rationale and time points for obtaining pet scans is planned with respect to the typical natural history of metastatic rcc. this project will obtain information from tumors that are responding to anti-angiogenesis therapy and those resistant to treatment.

Eligibility criteria:
inclusion criteria: * patients diagnosed with locally advanced (\>/=ct3) or metastatic clear cell rcc as proven by biopsy. * adults, 18 years of age or older. * surgical candidates who have clinical indication for nephrectomy and standard-of-care biopsy of metastatic disease followed by possible standard of care systemic anti-angiogenesis based treatment regimen * have consented to participate in the university of wisconsin carbone cancer center biobank. exclusion criteria: * patients who have received prior rcc systemic therapies * prior history of prostate cancer * prior history of any other malignancy within the last 2 years, other than skin basal cell or cutaneous superficial squamous cell carcinoma that has not metastasized and superficial bladder cancer * unable to lie flat during or tolerate pet/ct * serum creatinine \> 2 times the upper limit of normal

Keywords: clear cell kidney cancer rcc
efficacy of microcurrent therapy for treatment of knee pain

Conditions: Acute Knee Pain

Summary: the purpose of this study is to evaluate the effect of microcurrent therapy at the knee pain.


Eligibility criteria:
inclusion criteria: * pain perceived as a minimum of 3/10 on a 0-10 pain scale * no phobia of electrical stimulation * no pain or anti-inflammatory medication will be taken during study * injury that began prior to 6-weeks ago before the onset of pain * grade ii soft tissue injury exclusion criteria: * pregnancy * diabetes mellitus * neuropathy * smoker * uncontrolled htn * past surgery in the region to be treated by microcurrent * arthritis (ra) in the area to be treated by microcurrent * cardiovascular disease * allergic to tape/electrodes * ligament injury * patella femoral pain syndrome (anterior knee pain) * dementia * grade iii soft tissue injury