Kornimate/medical-research-clean huggingface dataset:
cognitive processing therapy (cpt) for posttraumatic stress disorder and borderline personality disorder (ptsd-bpd)

Conditions: Posttraumatic Stress Disorder; Borderline Personality Disorder

Summary: posttraumatic stress disorder (ptsd) with co-occurring borderline personality disorder (bpd) (i.e., ptsd-bpd) is common (as high as 58%), debilitating, costly, and limited treatment options available for this population. ptsd-bpd is associated with even greater functional impairment and higher healthcare burden than either disorder alone. there are surprisingly few treatments available for this clinical profile, despite its association with major negative health outcomes, cost, and morbidity. there is a pressing need to innovate treatments that can effectively and efficiently treat ptsd-bpd. the existing treatments used for ptsd-bpd are lengthy, laborious, resource-intensive, and require complete cessation of suicidal behaviors prior to treatment. furthermore, no integrated treatment has been innovated to deliver the active ingredients to efficiently affect the mechanisms underpinning this comorbidity. the investigators propose to examine an adapted version of a first-line ptsd intervention, cognitive processing therapy, augmented with a suicide risk management, i.e., (cpt+srm) as a brief (12 sessions) and more parsimonious treatment alternative that strategically targets shared mechanisms underpinning ptsd and bpd. the purpose of this pilot study is to 1) collect initial feasibility, acceptability, and safety data on this adapted treatment, 2) conduct a pilot randomized clinical trial evaluating the efficacy of cpt+srm versus treatment as usual (tau) + srm, and 3) evaluate two targets (i.e, improvements in emotional intensity and cognitive dysfunction) as mechanisms leading to change in our primary outcomes. both treatment conditions will be administered via telehealth. potential benefits include reduction in participants' ptsd, bpd and other mental health symptoms. additionally, this work could benefit the community by improving the treatment repertoire for ptsd-bpd. potential risks include emotional distress, suicidality, and/or self-harm. participants may experience discomfort and/or distress while discussing participants trauma(s) and mental health. these risks will be mitigated using a suicide risk management protocol which therapists in the assessment of risk and protective factors of suicide, followed by documentation for the decision-making around the management of risk.


Eligibility criteria:
inclusion criteria: * aged 18-65 years * must reside in the bay area, ca * current dsm-5 diagnosis of ptsd and bpd * must be willing to be audio- or videorecorded for assessment and treatment sessions exclusion criteria: * acute mania, acute psychosis, or intellectual disability * conditions requiring medical attention to a potentially life-threatening illness (e.g., severe anorexia nervosa) * severe impairments in written and aural comprehension * eu individuals

Keywords: cognitive processing therapy suicide risk management suicide self-harm
platelet rich plasma (prp) as a treatment for achilles tendon tears

Conditions: Achilles Tendon Tear

Summary: to review the influence of patient derived prgf on the healing process of achilles tendon after a surgical correction of a complete tear.

autologous platelet-rich matrices may aid in post surgical patients by promoting and accelerating tissue healing because of the release of growth factors including transforming growth factor (tgf)-beta1 and platelet-derived growth factor (pdgf) from platelet alpha-granules.

Eligibility criteria:
inclusion criteria: * a complete tear of achilles tendon * age 18-50 years old exclusion criteria: * under 18 year of age * pregnancy * physical or mental disabilities

Keywords: achilles tendon
transcranial alternating current stimulation (tacs) in stuttering

Conditions: Stuttering, Adult; Stuttering, Childhood; Stuttering, Developmental

Summary: the purpose of this study is to investigate how mild, noninvasive electrical brain stimulation affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people that stutter. the long-term goal of this study is to test the therapeutic potential of transcranial alternating current stimulation (tacs) for the treatment of stuttering. the study team hypothesizes that if stuttering involves impaired initiation of motor programs, delta-tuned tacs will strengthen communication between brain regions and decrease stuttering. therefore, the study team delta-tuned sensorimotor tacs will be paired with fluency-induced speech (choral reading), which is hypothesized to decrease stuttering via improved auditory motor integration. however, if the primary impairment lies in planning of motor programs, the study team hypothesizes that theta-tuned tacs will strengthen communication between prefrontal and temporal brain regions and decrease stuttering.

participants will have screening and baseline visits that include a variety of tests and procedures (i.e. standardized tests of speech, language, hearing test, music training questionnaire, working memory tests, and speech sample to characterize stuttering, magnetic resonance imaging (mri) and electroencephalography (eeg)). following these, participants will have 5 sessions (active and sham conditions) and then a one month follow-up phone call. of note, there will be an embedded pilot study to refine the experimental protocol in terms of practicality and feasibility and these participants will not be included in this registration. the only purpose of this embedded study is to refine the protocol and it does not have any health or behavioral outcomes.

Eligibility criteria:
inclusion criteria for stutterers: * have normal language, hearing, and cognition * speak english as the primary language * currently stutter * score (per protocol) a certain value on the stuttering severity instrument (ssi-4). * have not received any treatment for stuttering within the past year exclusion criteria for stutterers: * history of seizures * major medical or neurological illness (e.g., stroke, serious head trauma, brain infection, parkinson's disease, etc.) * history of closed head injury with loss of consciousness (e.g., concussion) * metal or electronic implants such as cochlear implants and pacemakers anywhere in the body * braids or other hair styling that prevents direct access to the scalp (if removal not possible) * currently pregnant

Keywords: tacs magnetic resonance imaging electroencephalogram auditory perturbation neural oscillations nonword repetition brain stimulation
dyadic approach to active living and eating healthy: the date study

Conditions: Obesity

Summary: the purpose of the date study is to evaluate the feasibility and acceptability and a preliminary evaluation of the efficacy of a dyadic health behaviour change intervention to improve healthy eating, physical activity, and dyadic coping among older obese couples. this novel intervention will use a dyadic adaptation of common health behaviour change strategies and will promote a dyadic coping approach to health behaviour change that emphasize partners' interdependence and shared responsibility for the creation of a home environment conducive to a healthy lifestyle. for this project 35 obese older adults cohabiting dyads will be randomized to either the couples-based dyadic health behaviour change intervention or a couples-based nutrition counselling control condition.


Eligibility criteria:
inclusion criteria: * at least one of the partners is retired * partners cohabitating for at least 2 years. * obesity: bmi between 30-45 kg/m2 exclusion criteria: 1. currently enrolled in a weight loss program 2. on a special diet 3. eating disorder 4. uncontrolled diabetes 5. stroke 6. heart problems (heart attack, heart failure, surgery of the heart or of the carotid arteries, pacemaker) 7. other medical issues or medical treatment that would prevent doing physical activity
diabetes, insulin resistance and body composition

Conditions: Insulin Resistance, Diabetes

Summary: the goal of this retrospective study is to learn about the correlation between diabetes, insulin resistance and body compositions. the main question\[s\] it aims to answer are: * \[the difference of body composition between the individuals of insulin resistance and diabetes\] * \[the effect of diabetes on body composition\]


Eligibility criteria:
inclusion criteria: 1. adults aged 18 years and older. 2. diagnosed with type 2 diabetes mellitus according to recognized diagnostic criteria. 3. availability of complete body composition data (e.g., dxa measurements). 4. documented hba1c levels and other glycemic control data. 5. continuous medical records available during the study period exclusion criteria: 1. presence of other severe metabolic diseases, such as liver failure or kidney failure. 2. use of medications affecting muscle mass (e.g., glucocorticoids) for more than three months. 3. history of malignancy or ongoing treatment for cancer. 4. missing critical research data (e.g., diabetes duration or hba1c levels). 5. history of surgeries causing significant body composition changes (e.g., bariatric surgery).
hands on nutrition education to improve childhood health

Conditions: Health Behavior; Nutrition Poor

Summary: the main goals of this study is to better understand how an experiential cooking, movement and mindfulness intervention influence elementary school children at spring valley school. program diet, fitness, metabolic outcomes, health literacy and overall well-being. specifically, the role of the novel empowering experiential learning through a cooking and fitness intervention activities will play on health literacy and metabolic outcomes, engagement in fitness and motivation, and stress levels will be evaluated.

nutrition and mindful movement program activities will take place during the school day. children will be given the opportunity understand the value of quality nutrition in the prevention com-morbidities of treatment and poor lifestyle choices. the intervention will consist of ten sessions. this includes pre- and post-assessments (weeks 1 and 10) and eight weekly 1-hour interactive culinary medicine education sessions. children will be asked questions about their diet, feelings, physical activity. height, weight, waist circumference, and grip strength will also be measured. this will take about one hour prior to beginning the education portion of our program. each week, \\a nutrition lecture, a cooking demo and fitness activities will be completed over two-45 minutes sessions during pe class. these hands-on applied nutrition sessions include fundamental of nutrition, cooking skills, cooking skills, and activities. experiential or hands-on applied learning, including culturally appropriate meal preparation and personalized nutrition and mindful movements, represents a potential tool to increase adolescent health literacy as well as empower adolescent to engage their families. cooking as medicine helps people make the healthy behavior changes they are seeking because it allows hands-on teaching and learning in a fun interactive environment, without stigma. this strategy encompasses combination of thinking and doing skills that are applied during home food preparation, as well as conceptual and perceptual abilities on food handling, safety and storage, and other factors related to nutrition. the delivery of cooking as medicine programs serves as a way to improve and promote confidence, well-being, and enhance meal quality and preparation practices and offer a valuable platform to engage children and families via inclusive social activities, whilst positively impacting their dietary profiles and health outcomes.

Eligibility criteria:
inclusion criteria: * speak and read english able to ambulate student at selected school exclusion criteria: * medical condition precluding participation
disseminating evidence-based practice to the schools: cbt for child anxiety

Conditions: Anxiety Disorders

Summary: the present study aims to test the implementation and sustainability of (a) a computer-assisted cognitive-behavioral treatment (cacbt) for youth anxiety and (b) the basc-2 trs to identify anxious youth in the school setting using a cohort-sequential design (i.e., three years at 20 schools over the span of five years). 'camp cope-a-lot (computer-assisted cbt program)'

the present study will test the implementation and sustainability of (a) a computer-assisted cognitive-behavioral treatment (cacbt) for youth anxiety and (b) the basc-2 trs to identify anxious youth in the school setting using a cohort-sequential design (i.e., three years at 20 schools over the span of five years). there are 3 phases: phase i (baseline): gather data on prevalence and services provided via screening measures and treatment trackers: phase ii (implementation): train school staff in the identification of anxious youth (i.e. basc-2 trs) and the provision of the intervention (i.e., cacbt), modifying assessment and treatment procedures so as to best fit each individual school. identify barriers and facilitators of implementation by gathering the qualitative experience of school staff: phase ii (sustainability): discontinue training and supervision. assess sustainability of the assessment and intervention. identify barriers and facilitators of implementation by gathering the qualitative experience of school staff. 'camp cope-a-lot (computer-assisted cbt program)"

Eligibility criteria:
inclusion criteria: * all mental health workers (e.g., guidance, social work, school psychologists) in the schools will be eligible to be trained. exclusion criteria: * none.
cutaneous effects of cryogen spray cooling

Conditions: Pain

Summary: cryogen spray cooling spurt is applied to the skin surface immediately before laser exposure. as liquid cryogen rapidly evaporates, the superficial skin temperature is reduced as a result of supplying the latent heat of vaporization. tetrafluoroethane, an environmentally compatible, non-toxic, non-flammable freon substitute, has been demonstrated in multiple studies to be a safe and effective cooling agent and is the only cryogenic compound currently approved for dermatologic use by the food and drug administration.

the researcher can use laser treatment in combination with cryogen spray cooling. the specific aim of this study is to characterize the clinical cutaneous effects of varying spurt durations and spurt delivery patterns that spurt durations of 100 ms or less will result in a very low incidence (less than 2%) of clinical skin effects (redness, blistering, local skin allergic reaction or skin discoloration) in any skin type. researchers can use cryogen spray cooling to protect the skin epidermis during laser therapy to decrease treatment pain, allow safe treatment of darker skin types, and safe use of high laser fluences. cryogen spray cooling with tetrafluoroethane has been incorporated into many food and drug administration approved, commercially available laser devices currently used for treatment of vascular lesions, hair removal and non-ablative skin rejuvenation.

Eligibility criteria:
inclusion criteria: * adult 18 years and older exclusion criteria: * age \<18 * history of cold sensitivity * inflammatory rash on the test site

Keywords: skin cooling during laser treatment
construction and preliminary application of com-b based sedentary behavioural booster intervention programme for elderly stroke patients

Conditions: Stroke

Summary: explore the application effect of the sedentary behaviour intervention program for elderly stroke patients based on the com-b model.

the goal of this clinical trial is to text about in the application effect of the sedentary behaviour intervention program for elderly stroke patients based on the com-b model. the main question it aims to answer are: * changes in sedentary behaviour in elderly stroke patients participants will received a 12-week sedentary behaviour intervention programme. researchers will compare differences in sedentary behaviour between routine care control and intervention groups.

Eligibility criteria:
inclusion criteria: * meet the diagnostic criteria for cerebral infarction and cerebral hemorrhage in the diagnostic points for various major cerebrovascular diseases in china 2019 issued by the cerebrovascular disease group of the neurology branch of the chinese medical association; * age ≥60 years; * national institute of health stroke scale (nihss) score \<5 (i.e., mild stroke), stable vital signs, and able to cooperate with the survey; * total sedentary time ≥6 hours/day measured using the international physical activity questionnaire; * resident for ≥6 months in the community residents; * patients or under the guidance of others can use wechat. exclusion criteria: * functional ambulation category scale (fac) score \<2; * serious myocardial infarction, cerebral hemorrhage and pulmonary embolism in the acute stage of the need to limit the activities of the situation; * is participating in other physical activity or sedentary behavioral intervention programs; * severe muscle weakness, fractures and other diseases resulting in limited physical activity; * serious mental disorders such as schizophrenia or dementia resulting in severe cognitive impairment; * speech and communication disorders.
rectal misoprostol as a hemostatic agent during abdominal myomectomy

Conditions: Myomectomy; Surgical Blood Loss

Summary: purpose is to identify if misoprostol in addition to local vasopressin decreases blood loss when compared to vasopressin alone, which is our current practice at this time. the study will be double-blinded with neither the patient nor the researcher knowing whether the placebo or the misoprostol was given. we will monitor patients for decrease in hemoglobin and hematocrit, need for transfusion, and operative time among other measures of perioperative morbidity to see if the addition of misoprostol makes a significant difference. we will also observe patients to see if there are any side effects of misoprostol that make its use undesirable.

all women with planned myomectomy receive depo leupron prior to surgery per standard care and undergo routine pre-operative laboratory testing including hemoglobin and hematocrit. if enrolled in the study, patients will be consented at their pre-op appointment for the study and be asked to complete a visual analog scale to assess pre-operative pain. patients will be randomized to receive misoprostol 800mcg per rectum or an identical inert tablet(s) per rectum 30 minutes preoperatively. randomization will be performed by a third party so that neither the surgeon nor patient will know which intervention was performed, and interventions will be placed in sealed, sequentially numbered, opaque envelopes. researcher team will have all needed data corresponding with randomized code which will be broken at conclusion of study and will be able to match code with patient's initials and medical record number after study completion to analyze data. myomectomy will then be performed per standard care with the use of local vasopressin to aid in decreasing blood loss per our normal standard of care.

Eligibility criteria:
inclusion criteria: * female age 20-50 y/o who plan to undergo abdominal myomectomy for symptomatic myomatous uterus exclusion criteria: * patient with contraindication to misoprostol or vasopressin, personal history or cardiac or pulmonary disease, history of prior myomectomy

Keywords: myomectomy, misoprostol, vasopressin, blood loss
interval training and resting metabolism

Conditions: Healthy Subjects

Summary: it has been reported that obese individuals are seated 2 ½ hour more than lean individuals and that non exercise thermo genesis (neat) may vary with as much as 2000 kcal/day between equal size people due to different occupational and leisure time activities. the primary aim of the study is to investigate if 10 weeks of exercise training increase neat in sedentary men. subject will be randomized to three different training intervention, with 3 exercise session each week for 10 weeks. neat will be measured using an activity sensor and recorded over a 7 day period both before and after training.


Eligibility criteria:
inclusion criteria: * male gender * age 18-50 * bmi 25-30 kg x m2 * no significant comorbidities * abel to exercise * not partaking in organized physical activity exclusion criteria: * inability to exercise due to musculoskeletal conditions * known ischemic cardiovascular disease * high daily physical and occupational activity levels

Keywords: neat maximal oxygen uptake stroke volume
safety and efficacy study of intravenous loading dose of ibandronate in breast cancer patients

Conditions: Breast Cancer

Summary: the purpose of the study is to determine the efficacy and safety of a three time repeated loading dose of intravenous ibandronate (ibandronic acid), 6 mg, in breast cancer patients with painful skeletal metastases.

painful skeletal metastases are a common site of advanced disease. for instance, in breast cancer, and despite cancer treatments (radiotherapy, cytotoxic treatment and adequate treatment of pain), the patients often need additional treatments that may relieve their symptoms. bisphosphonates, such as ibandronic acid, have in pilot studies shown a significant decrease in pain scores, both after loading dose and after long-term treatment. in this study the safety and efficacy of an intravenous loading dose of three times 6 mg ibandronate during three consecutive days in breast cancer patients with painful skeletal metastases will be studied.

Eligibility criteria:
inclusion criteria: * breast cancer with presence of bone metastases * pain score over 4 on the vas exclusion criteria: * patients with pathological fractures or medulla compression or neuropathic pain * patients with infection or corticosteroid treatment * pregnant or lactating patients

Keywords: breast cancer skeletal metastases bisphosphonate therapy breast cancer with painful skeletal metastases
preoxygenation with optiflow™ - the effect of speech on lung oxygenation.

Conditions: Unrecognized Condition

Summary: if a patient speaks during the process of preoxygenation with high-flow nasal oxygen via the optiflow™ system, is the efficacy reduced as measured by end-tidal lung oxygen content?

this is a randomised controlled trial on 34 patients undergoing routine elective surgery at the princess anne hospital, southampton. the study will take place from september 2018 to january 2019 and involve preoxygenating all participants for three minutes using the optiflow™ device. during this time, participants will be instructed to either read aloud a standardised text or to breathe through their nose with a closed mouth. at the end of 3 minutes, the primary outcome, eto2, will be measured and recorded.

Eligibility criteria:
inclusion criteria: * bmi 18-35, asa category 1 or 2 exclusion criteria: * inability to read/ follow instructions, heavily sedated

Keywords: optiflow high flow nasal oxygen preoxygenation speech