Kornimate/medical-research-clean huggingface dataset:
impact of non-magnetic screen respiratory self-guidance during mri-guided radiotherapy sessions for mobile lesions

Conditions: Patient With Radiotherapy (Linac MRI); Mobile Cancerous Lesion

Summary: the patients eligible for the study are those treated by radiotherapy on linac mri for a mobile cancerous lesion (pancreas, liver, kidneys, adrenals, lung, adenopathy above or below the diaphragm ...). after signing the consent form, each patient will be randomized to one of two treatment arms: * standard arm : radiotherapy treatment with linac mri without non-magnetic shielding * experimental arm : radiotherapy treatment with linac mri with non-magnetic screen the aim is to evaluate the effect of using a non-magnetic screen visible to the patient in the bunker during radiotherapy sessions delivered by linac mri on decreasing the ratio between the actual treatment time and the treatment time predicted by the machine.

the patients eligible for the study are those treated by radiotherapy on linac mri for a mobile cancerous lesion (pancreas, liver, kidneys, adrenals, lung, adenopathy above or below the diaphragm ...). after signing the consent form, each patient will be randomized to one of two treatment arms: * standard arm : radiotherapy treatment with linac mri without non-magnetic shielding * experimental arm : radiotherapy treatment with linac mri with non-magnetic screen the aim is to compare the effect of the non-magnetic screen on the blocking of the patient's breathing versus the current procedure (the blocking of the breathing is informed by the staff) the patients will each receive 5 sessions of radiotherapy on linac mri. 100 patients are expected to participate in this study before each session will be assessed for anxiety and stress. after each session will be evaluated patient satisfaction, pain intensity and respiratory effort. the duration of the treatment and therefore of the follow-up of the patient in the study is 1 to 2 weeks

Eligibility criteria:
inclusion criteria: * patient is at least 18 years old * patient starting radiotherapy on linac mri for a mobile cancerous lesion most often in the pancreas, liver, kidneys, adrenals, lung, supra or subdiaphragmatic adenopathy * patient affiliated to the social security system exclusion criteria: * patient with lesions not detected by the device's tracking system * patient with visual disturbances * contraindications to treatment with linac mri (epileptic patients, pregnant or breastfeeding women, metallic prosthesis or pacemaker not compatible with mri) * patients with cognitive disorders * persons deprived of liberty or under guardianship (including curatorship) * pregnant or nursing woman * refusal to participate in the study

Keywords: linac irm pancreatic cancer liver cancer kidney cancer adrenal cancer lung cancer adenopathy above or below the diaphragm
androgenetic alopecia in fabry disease

Conditions: Fabry Disease

Summary: the purpose of this study is to assess whether patients with the classic form of fabry disease have significantly less androgenic alopecia (male pattern baldness).

objectives: to test the hypothesis that adult males with classic form of fabry disease have a significantly lower incidence of androgenic alopecia than matched controls. study population: 120 patients aged 20-64 with fabry disease that have gla mutations or alpha-galactosidase a activity associated with no residual enzyme activity and non-fabry male controls of the same age range and the same number of non-fabry controls. design: this is a cross-sectional study comparing the prevalence of androgenic alopecia in two groups of subjects. outcome measures: the levels of the outcome will be no androgenic alopecia and frontal only androgenetic alopecia opposed to vertex only and frontal and vertex androgenetic alopecia.

Eligibility criteria:
inclusion criteria: * male patients with fabry disease age 20-64 years old. * healthy male controls age 20-64 years old * gla gene mutations associated with the classic form of fabry disease or having alpha-galactosidase a activity that is essentially zero * patients who freely agree to participate in this study and understand the nature, risks and benefits of this study and give their written informed consent.

Keywords: fabry disease male pattern baldness alopecia gla gene mutation alpha-galactosidase a
a 12-gene blood-based signature for detecting metastatic bladder cancer

Conditions: Bladder Cancer

Summary: the purposes of this study is to evaluate a new genetic-based test which will identify patients diagnosed with muscle-invasive bladder cancer before their surgery, who might have specific genes, which will increase their chances of recurrence of cancer after their surgery. some patients who are diagnosed with bladder cancer and have their had bladder removed, will have a recurrence of cancer sometime after their surgery. this recurrence is usually caused by tumor cells that originated from the bladder tumor and traveled to other parts of the body, which is called metastatic cancer. some patients are more likely than others to have metastatic disease. this test may help in identifying these patients who might develop metastases from having these specific genes.


Eligibility criteria:
inclusion criteria: * patients in whom pelvic lymph node dissection can be performed; * any male and/or female, who is ≥18 years of age; * pathological diagnosis of urothelial carcinoma of the bladder; * localized muscle-invasive disease defined as clinical stage t2-4an0m0 tumors; * did not receive neoadjuvant therapy; * no radiographic evidence of metastatic disease on ct scans of the abdomen and pelvis, chest x-ray, or bone scan; * informed consent before study participation exclusion criteria: * prior systemic chemotherapy; * prior radiation therapy; * a history of another ongoing malignancy within the past 5 years other than basal cell carcinoma of the skin

Keywords: urinary bladder bladder blood sample lymph nodes
is topiramate effective in treating dizziness in patient's with migraine-associated dizziness

Conditions: Migraine; Headache; Dizziness

Summary: the purpose of this study is to determine whether topiramate effective in treating dizziness symptoms that are associated with migraine headaches.

migraine is a common disorder, often associated with dizziness symptoms. in many cases, dizziness is one of the only manifestations of migraine headaches. various classes of drugs have been advocated as treatment for migraine-associated dizziness, though none has been shown to be superior over the others. topiramate is a drug approved for migraine prophylaxis. this study is designed to assess if there are significant changes in dizziness frequency and severity in patients diagnosed with migraine-associated dizziness treated with topiramate. demonstrating benefit of topiramate with a placebo-controlled study to alleviate symptoms of dizziness would serve to clarify effective treatment options for patients with migraine-associated dizziness.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of migraine-associated dizziness. exclusion criteria: * previous or current use of topiramate prior to study enrollment. * need for continued use of the following medications for any medical reason during the study: ergots, anti-epileptics, beta-blockers, calcium channel blockers, monoamine oxidase inhibitors, high-dose magnesium, high-dose riboflavin, corticosteroids, local anesthetics, botulinum toxin, or herbal preparations. * history of nephrolithiasis. * women whom are pregnant or breastfeeding. * patients with known sensitivity to topiramate. * patients with a history of glaucoma. * patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study.

Keywords: migraine headache dizziness vertigo topiramate topamax
the dissemination of consensus recommendations on upper gastrointestinal bleeding

Conditions: Peptic Ulcer Hemorrhage

Summary: the purpose of this study is to assess whether adherence to nvugib guidelines is improved with implementation of a national, tailored multifaceted intervention. outcomes include adherence rates to two key endoscopic and pharmacological therapy guidelines together (primary), or adherence to these individually as well as to other recommendations (secondary). patient outcomes and economic data are also assessed (tertiary).

clusters are randomized to receive a published algorithm and guidelines (control group), or a multifaceted, tailored educational intervention (see details in protocol - intervention group). the charts of treated patients with non variceal upper gi bleeding are reviewed and adherence to selected guidelines recorded.

Eligibility criteria:
inclusion criteria: * age 18 or over. * treated during the study duration * primary or secondary discharge diagnoses of nvugib (per charted icd-10 code). additional confirmation of nvugib using endoscopic findings or patient symptoms done as previous. exclusion criteria: * patients initially assessed at another institution for the present episode of nvugib and subsequently transferred to the participating site with unavailable initial data. * endoscopy noted no gastro-duodenal ulcer bleeding, to ensure patient homogeneity.

Keywords: peptic ulcer bleeding upper gi hemorrhage adherence to guidelines knowledge transfer
effectiveness of deep cervical flexor muscle exercises in patients with tension-type headache

Conditions: Tension-Type Headache

Summary: the aim of this study is to evaluate the effects of deep cervical flexor muscle exercises on pain, spinal posture, and sensory sensitivity in patients with tension-type headaches. designed as a single-blind randomized controlled trial, the study will assess participants' pain levels using the visual analog scale (vas), sensory sensitivity through the sensory sensitivity scale, and spinal posture via a digital inclinometer for objective measurements. this research seeks to determine the effectiveness of these exercises in managing pain, improving spinal posture, and contributing to the enhancement of sensory sensitivity.

the objective of this study is to comprehensively evaluate the impact of deep cervical flexor muscle exercises on three key outcomes in patients suffering from tension-type headaches: pain intensity, spinal posture, and sensory sensitivity. tension-type headaches, often associated with poor posture and muscular dysfunction, can significantly affect daily functioning and quality of life. this study seeks to explore whether targeted exercises for the deep cervical flexor muscles can alleviate these symptoms. designed as a single-blind randomized controlled trial, this research will involve carefully selected participants who will be randomly assigned to either an intervention group or a control group. the intervention group will undergo a structured exercise regimen focusing on deep cervical flexor muscles, while the control group will not receive this specific intervention. to measure the effectiveness of the intervention, three primary assessment tools will be employed: pain levels will be evaluated using the visual analog scale (vas), which provides a subjective yet widely accepted measure of pain intensity; sensory sensitivity will be assessed using the sensory sensitivity scale, offering insight into changes in sensory perceptions related to the headache condition; and spinal posture will be objectively measured using a digital inclinometer, which quantifies postural alignment and deviations. this research aims to contribute to the understanding of non-pharmacological interventions for tension-type headaches, providing evidence on whether deep cervical flexor exercises can reduce pain, improve spinal posture, and positively influence sensory sensitivity, potentially offering a holistic approach to managing these chronic headaches.

Eligibility criteria:
inclusion criteria: * being diagnosed with tension-type headache exclusion criteria: * whiplash injury, * significant neck trauma (caused by trauma to the neck, fracture, distortion, or violent attack that have caused the current np), * nerve root compression of the cervical spine, * persistent headache attributed to traumatic injury to the head * cluster headache, * trigeminal neuralgia, * pregnancy, * breastfeeding, * severe physical and/or mental illness

Keywords: tension-type headache pain posture sensory sensitivity
cardio-respiratory responses during hypoxic exercise in individuals born prematurely

Conditions: Hypoxia; Altitude Sickness; Tolerance

Summary: this project will consist of two studies, each investigating resting and exercise cardio-respiratory responses during exposure to hypoxia in individuals born prematurely and individuals born at full term of two different age groups: kids (10-14 yrs) and adults (18-22 yrs).additional study will be performed on a preterm adult cohort (15 participants) that will investigate potential differences between hypobaric and normobaric hypoxia as outlined in the following section.

the study protocol in each age group will comprise two visits to the laboratory testing sessions in a randomized order. on one occasion the participants will perform a resting hypoxia test and a graded exercise test to voluntary exhaustion in normoxic condition ((norm; fraction of inspired oxygen (fio2)=0.209, placebo). on a second visit the participants will perform a hypoxia sensitivity test and a graded exercise test to voluntary exhaustion in hypoxic condition (hypo; fio2=0.120 corresponding to terrestrial altitude of approx. 4000 m). indirect calorimetry, near infrared spectroscopy and ecg measurements will be performed throughout all tests. during both testing sessions the participants will also undergo anthropometry measurements and pulmonary function testing. the outline of the research visits is presented in the bellow figure:

Eligibility criteria:
inclusion criteria: healthy male individuals preterm group; gestational age: ≤ 32 weeks; gestational weight ≤ 1500 g control group: full term born individuals ≤ 38 weeks exclusion criteria: medication required that may interfere with the interpretation of the results chronically illnesses hormonal therapy recent sub-standard nutritional status family history of respiratiory, cardio-vascular, renal or hematological disease history of: thyroid dysfunction, renal stones, diabetes, allergies, hypertension, hypocalcaemia, uric acidaemia, lipidaemia or hyperhomocystinaemia history of mental illness smoker within six months prior to the start of the study abuse of drugs, medicine or alcohol participation in another study up to two months before study onset no signed consent form before the onset of the experiment blood donors in the past three months before the onset of the experiment vegetarian and vegans migraines history of vestibular disorders claustrophobia
a study comparing topical skin adhesive or sutures for closure due to episiotomy or perineal tears following childbirth

Conditions: Episiotomy; Perineal Tear

Summary: this is a randomized controlled trial and multi-centered study with a 2-arm design. the treatment group will receive topical skin adhesive for skin closure of their wound and the control will receive sutures. subjects will be assessed at follow-up visits. patients are required to maintain a diary postpartum.


Eligibility criteria:
inclusion criteria: * patient is at least 18 years of age. * patient has an episiotomy incision or perineal tear resulting from a vaginal delivery. * patient agrees to participate in the follow-up schedule of assessments and completion of a daily diary. * patient has signed the informed consent form. exclusion criteria: * patient has peripheral vascular disease. * patient has insulin dependent diabetes mellitus. * patient has a blood clotting disorder that requires therapy. * patient has a personal or family history of keloid formation or hypertrophy. * patient has a known allergy to cyanoacrylates or formaldehyde. * patient has impaired wound healing by history. patient is a chronic steroid user.

Keywords: childbirth
trial of long-term therapeutic hypothermia for poor-grade aneurysmal subarachnoid hemorrhage

Conditions: Hypothermia; Aneurysmal Subarachnoid Hemorrhage

Summary: this study is a prospective, multi-centre, randomized,controlled trial to compare the efficacy of long-term mild hypothermia with normothermic intensive management in patients with poor-grade aneurysmal subarachnoid hemorrhage. the primary hypothesis is that the induction of mild hypothermia (maintained at 32-35℃) for at least 5 days would improve the outcome of patients at six months post hemorrhage compared with normothermia.

aneurysmal subarachnoid hemorrhage (asah), especially poor-grade asah, is a medical emergency with very high morbidity and mortality rates. sah constitutes a major public health concern in developed and developing countries. there were several clinical trials of hypothermia for asah conducted, however, with conflicting results. hypothermia therapy treatment is currently used in our department and other large neurosurgical centers across china to decrease the intracranial pressure (icp), mitigate some of the destructive processes, and improve the functional outcome of patients with poor-grade asah. when the decision was made, the patients would be placed in wrapped cooling blankets or intravascular cooling device after they were sedated, intubated and mechanically ventilated. the patients would receive continuous infusions of some drugs using an infusion pump to prevent shivering. once the patient's rectal, nasopharyngeal or blood temperature reached 32˚c, it was kept at approximately that temperature (32-35˚c) 3 to 7 days. then the patients were passively rewarmed to a temperature of 36 to 37˚c at a rate no greater than 0.25˚c/hour, by gradual adjustment of the blanket thermostat. the present multi-center, randomized controlled trials is designed to investigate the efficacy and safety of long-term (3 days) mild hypothermia versus normothermia on the outcome of patients with poor-grade asah. the primary outcome is the neurological function assessed at 1,3, 6 months post injury with the glasgow outcome score (gos). additionally, the following data will also be recorded and compared: the baseline data, glasgow coma score,imaging examination (e.g. ct scan), intracranial pressure, laboratory tests (e.g. blood routine test, liver and kidney function, blood gas analysis, etc), the complications (e.g. pneumonia, significant bleeding) and so on.

Eligibility criteria:
inclusion criteria: * age 18 - 65 years within 72 hours after subarachnoid hemorrhage; * neurosurgical clipping or coiling for aneurysm; * hunt-hess iv-v scale; * the intracranial pressure is more than 20 mmhg. exclusion criteria: * gcs of 3 with bilateral fixed and dilated pupils; * no spontaneous breathing or cardiac arrest at the scene of hemorrhage; * no consent; * pregnancy.
comparison of adenoma detection miss rates at colonoscopy associated with different withdrawal times

Conditions: Adenoma and/or Adenocarcinoma; Adenoma

Summary: the objective of this study is to determine the optimal withdrawal time for colonoscopy. a 6-minute withdrawal time is currently the standard of care but has only been evaluated in an observational fashion. the investigators believe that this should be validated in a standardized fashion. if the benefits of a 6 minute withdrawal are proven in this study (ie a low polyp/adenoma miss rate and a high polyp/adenoma detection rate), then this will support widespread adoption of a 6 minute withdrawal as the standard of care. this in turn may decrease the occurence of 'interval colon cancers', which are early colon cancers arising in subjects despite their having undergone colonoscopy. our hypothesis is that the polyp/adenoma detection rate will be unacceptably low and the polyp/adenoma miss rate will be unacceptably high in the 3-minute withdrawal group when compared to the 6-minute withdrawal group.

eligible patients will be randomized to colonoscopy with either a 6-minute withdrawal time or a 3-minute withdrawal time. patients will then undergo colonoscopy. all colonoscopies will be performed by a gi attending (standard of care). the colonoscopy is typically performed under conscious sedation using medications such as fentanyl and midazolam for comfort (standard of care). occasional patients undergo colonoscopy under general anesthesia. for all patients, advancement of the colonoscope to the cecum will be followed by segmental withdrawal of the colonoscope in each of 3 segments of the examined colon (right side of colon, transverse colon and left side of colon). following examination of each individual segment, the colonoscope will be readvanced to the proximal end of the segment and a 2 minute withdrawal will be re-performed. for those randomized to the 6-minute withdrawal each segment will be examined over 2 minutes, followed by a "second look" over each segment over 2 minutes by the same endoscopist. for those randomized to the 3-minute withdrawal time, advancement to the cecum will also be followed by segmental withdrawal in each of 3 segments of the examined colon. each segment will be examined over 1 minute, followed by a "second look" over each segment over 2 minutes by the same endoscopist. all patients will therefore undergo a second look colonoscopy with a 6-minute withdrawal time ('de-facto' standard of care). polyp/adenoma detection and miss rates will then be calculated and compared between the two groups.

Eligibility criteria:
inclusion criteria: * age \> 18 * already scheduled for colonoscopy exclusion criteria: * age \< 18 * pregnant women * mentally disabled * decisionally challenged * cancer subjects * healthy volunteers * prisoners

Keywords: polyp/adenoma detection rate polyp/adenoma miss rate colonoscopy withdrawal time
prevention of incisional hernia after elective open abdominal aortic aneurysm (aaa) repair

Conditions: Abdominal Aortic Aneurysm

Summary: the aim of this study is to investigate the effect of the implantation of an ultrapro® mesh as prevention of incisional hernia after elective open abdominal aortic aneurysm repair. according to the literature these patients have an increased risk for an incisional hernia. by the implantation of an artificial mesh into the abdominal wall during the first abdominal aortic aneurysm repair, the risk can be reduced dramatically. in small feasibility studies incisional hernia rates as low as 0% have been achieved. patients scheduled for elective open abdominal aortic aneurysm repair will be randomized into two groups, one receiving an onlay mesh, the other conventional wound closure with sutures.

prospective randomized controlled study with two study arms. arm 1: abdominal wall will be closed with a prophylactic mesh implantation in onlay technique after elective open abdominal aortic aneurysm repair. arm 2: abdominal wall will be closed with standard sutures (without mesh implantation) after the patients gave their informed consent to participate in the study, they will be randomized to one of the two treatment arms. allocation is carried out based on a prepared randomization list. primary endpoint is the rate of incisional hernias within the follow-up period of 2 years. secondary endpoints are postoperative complications and adverse events during the follow-up period. study enrollment was prematurely terminated on 30. apr 2009. already enrolled patients will be followed for 24 months according to protocol.

Eligibility criteria:
inclusion criteria: * patient scheduled for elective or early elective open repair of aortic aneurysm exclusion criteria: * emergency surgery * evar (endovascular procedure) * patients with previous midline laparotomy * patients with in situ abdominal mesh after previous hernia repair * patients with large diastasis of abdominal wall * allergy to penicillin * women before menopause (mesh can interfere with potential future pregnancies)

Keywords: abdominal aortic aneurysm abdominal hernia