Kornimate/medical-research-clean huggingface dataset:
normal liver stiffness by mr elastography

Conditions: Liver Diseases

Summary: healthy children will be recruited to under magnetic resonance imaging (mri)along with mr elastography to determine normal liver stiffness values.

mr elastography (mre) is playing a growing role in the non-invasive diagnosis and monitoring of liver disease in the pediatric population. there is, however, little data specific to the use of this technique in children with existing data and techniques largely extrapolated from adult studies. existing studies suggest that liver stiffness values may be different between children and adults \[etchell, xanthakos\]. as such there is an unmet need for uniquely pediatric data in both healthy and diseased cohorts. to address the need for such data, the investigators plan a multi-site, prospective study of healthy pediatric (\<18 years of age) volunteers to determine normal liver stiffness measured by mr elastography across the range of mri equipment.

Eligibility criteria:
inclusion criteria: * age 7-17 years * no documented history of liver diseases * english speaking exclusion criteria: * npo less than 4 hours * body mass index \ 85th percentile for age * documented history of liver disease * pregnancy * inability to lie still for duration of the mri * inability to breath hold for the duration of the 15-20 second mr elastography sequence * standard contraindication to mri (implanted hardware, etc.) * requirement of sedation or general anesthesia for mri * abnormality of any measured liver function test * liver fat fraction \>5% by mri pdff
abdominal massage for gastric residual volume in surgical patients

Conditions: Gastric Residual Volume; Abdominal Distension; Enteral Nutrition; Massage Therapy

Summary: this randomized controlled trial aimed to evaluate the effect of abdominal massage on gastric residual volume (grv) and abdominal distension in surgical intensive care patients receiving enteral nutrition. the intervention group received 20-minute abdominal massage sessions twice daily for 3 consecutive days. outcomes included changes in grv, abdominal circumference, feeding volume, and gastrointestinal tolerance parameters.

gastric residual volume (grv) monitoring is commonly used in critically ill patients receiving enteral nutrition to assess gastrointestinal dysfunction, although current guidelines present conflicting recommendations regarding its necessity. abdominal distension is a frequent complication during enteral feeding in surgical icu patients. non-pharmacological interventions such as abdominal massage have shown promise in improving gastrointestinal motility and enteral tolerance. this study included 84 surgical icu patients who met the inclusion criteria and were randomly assigned to intervention (n=42) and control (n=42) groups. the intervention group received abdominal massage twice daily for 20 minutes over three days. data were collected using standardized forms and analyzed with appropriate statistical tests including independent samples t-test, mann-whitney u, repeated measures anova, and chi-square tests. the findings suggest that abdominal massage may help stabilize grv levels, reduce abdominal circumference, and increase nutritional intake without increasing complications.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * receiving enteral nutrition via nasogastric tube * no prior abdominal surgery * no invasive devices (e.g., drains, catheters) in the abdominal area exclusion criteria: * receiving enteral nutrition via peg or pej * receiving only parenteral nutrition * history of abdominal surgery

Keywords: enteral nutrition gastric emptying abdominal distension intensive care units, surgical postoperative care gastrointestinal motility disorders critical illness massage therapy
beating versus arrested heart for mitral valve replacement

Conditions: Mitral Stenosis; Mitral Insufficiency

Summary: the purpose of this study is to evaluate the immediately clinic and ultramicroscopic myocardial cellular ischemia and reperfusion to replace of the mitral valve using arrested heart versus on-pump empty beating heart surgical techniques.

during open-heart surgery prevention of ischemia and reperfusion following cardioplegic arrest are essential for myocardial protection. beating heart surgery on normothermic bypass simulates physiologic cardiac status and is good method for myocardial protection. a comparison of both available techniques for valve replacement arrested heart versus on-pump empty beating heart of the clinical and ultramicroscopic myocardial alterations will allowed to better understand myocardial protection because eliminated the use of cardioplegia and the corollary risk of ischemic reperfusion injury.

Eligibility criteria:
inclusion criteria: * all patient included into the study were adults 18-60 years old, * with an echocardiography diagnosis of mitral and/or tricuspid valve disease due to inflammatory acquired diseases, * no previous history of cardiac surgery and d) elective indication for valve replacement. exclusion criteria: * with metabolic diseases such as diabetes mellitus and uremia, * with coronary artery diseases, * dilated myocardiopathy, * with severe chronic pulmonary obstructive diseases, * with present or past history of malignant diseases, * acute endocarditis * with severe pre-operatory laboratory parameters such as creatinine levels \> 3mg/dl, hemoglobin ≤ 7.0 g/dl, prothrombin time/activity ≤ 70% and clotting time ≥ 10 minutes.

Keywords: mitral valve valve replacement arrested heart beating heart
correlation of blood gene expression (trugraf liver) with liver biopsy in pediatric liver transplant recipients

Conditions: Liver Transplant; Complications; Liver Failure, Acute

Summary: liver transplant rejection is when the body's immune system attacks and damages the liver of a transplant recipient. currently the best way to see if that is happening is with a liver biopsy. the purpose of this research study is to see if a simple blood test can diagnose if a transplanted liver is being rejected.

this study is an investigator-initiated, prospective, single-cohort trial to assess the ability of the trugraf® liver gene expression panel (gep) to predict rejection in pediatric liver transplant recipients undergoing surveillance and for-cause liver biopsy.

Eligibility criteria:
inclusion criteria: • all liver transplant patients at least 1 year of age and less than 18 years of age undergoing surveillance or for-cause liver biopsy exclusion criteria: • non-english, non-spanish speaking

Keywords: pediatric
study to compare the safety and efficacy of ub-851 and eprex®

Conditions: Renal Anemia

Summary: the primary objective of this study is to evaluate a 1:1 dose conversion from eprex® to ub-851 in terms of clinical efficacy and safety in subjects with chronic renal failure receiving hemodialysis.

this is a 52-week, phase iii trial consisting of two parts: part i is designed as a double-blind, randomized, multicenter, parallel-group study to evaluate the efficacy and safety of ub-851 in comparison to eprex® in subjects with renal anemia on hemodialysis with a treatment period of 24 weeks. part ii is designed as a single-arm, safety evaluation period (from week 25 to week 52) to evaluate the long-term safety and immunogenicity of ub-851.

Eligibility criteria:
main inclusion criteria: 1. subjects signed informed consent before undergoing any study procedures. 2. subjects aged 20 to 85 years. 3. hemodialysis subjects with chronic renal failure and renal anemia in outpatient clinic currently on stable eprex® treatment administered by intravenous injection (1 to 3 times per week) for at least 3 months prior to randomization. main exclusion criteria: 1. maintenance epoetin dose \> 300 iu/kg per week. 2. treatment with long-acting epoetin analogues. 3. detectable anti-erythropoietin antibodies with clinical symptoms at screening visit, or history of pure red cell aplasia (prca).
characterization of a prospective cohort of women with pcos

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovary syndrome (pcos) is a common endocrine disorder in premenopausal women. pcos is characterized by increase levels of testosterone, unwanted hair growth, adiposity, irregular menstrual cycle, and infertility. pcos is associated with diabetes mellitus and cardiovascular diseases. women with pcos are reported to have increased levels of stress hormones, which may be associated with decreased quality of life. increased testosterone levels in women may decrease the risk of osteoporosis. the aim of the present study is to measure levels of stress hormones in urine and describe quality of life using questionnaires. in addition we aim to characterize body composition and bone architecture using dxa and extremect. as part of the project, a biobank with fasting blood samples from participants is established.


Eligibility criteria:
inclusion criteria: * pcos exclusion criteria: * pregnancy

Keywords: pcos inflammation body composition
the study aims to improve the accuracy of detecting spina bifida during early ultrasound scans. to achieve this, an ai model has been developed to provide feedback about the presence of spina bifida. a rct has been designed to compare the effectiveness of ai feedback with no ai feedback.

Conditions: Spina Bifida

Summary: the study aims to improve the accuracy of detecting spina bifida during early ultrasound scans. to achieve this, an ai model has been developed to provide feedback about the presence of spina bifida. a rct has been designed to compare the effectiveness of ai feedback with no ai feedback.

the study aims to improve the accuracy of detecting spina bifida during early ultrasound scans. to achieve this, an ai model has been developed to provide feedback about the presence of spina bifida. a randomized controlled trial (rct) has been designed to compare the effectiveness of ai feedback with no ai feedback. forty fetal medicine specialists are randomly assigned to receive either the ai feedback or no feedback, and the two groups are compared to determine if the feedback improved the accuracy of detecting spina bifida.

Eligibility criteria:
inclusion criteria: * obstetricians exclusion criteria: * fetal medicine specialists
can cesarean scar defects be prevented?

Conditions: Isthmocele

Summary: in this study, uterotomy after cesarean section was performed using 3 different suture techniques and aimed to demonstrate the potential of the baseball suture technique to prevent the isthmusel complication known as cesarean scar defect.

an isthmocoele or cesarean scar defect is a pit-like defect in the myometrium at the isthmic level, thought to be the result of inadequate healing of the uterine incision after cesarean section. it is important not to underestimate isthmocele and to take preventive measures as it can lead to serious gynecologic and obstetric complications. however, which suturing technique is best in preventing isthmocele formation has not yet been established. the aim of this study was to compare the effects of 3 different uterine closure techniques on isthmocele formation during cesarean section. in this study, a total of 120 term (\>37 weeks) pregnant women with no previous cesarean section and scheduled for primary cesarean section will be randomized preoperatively to 3 different uterotomy closure techniques (baseball, single-lock and non-single-lock groups).

Eligibility criteria:
inclusion criteria: * pregnant women undergoing c/s for the first time * 37 weeks \< gestation (term pregnancies) exclusion criteria: * presence of regular contractions in the uterus * cervical dilatation of more than 4 cm, indicating the onset of the active phase of labour * placental abnormalities * previous uterine surgery * multiple pregnancy * premature rupture of membranes * chorioamnionitis * preoperative haemoglobin level below 10g/dl * body mass index (bmi) above 35kg/m2 * any comorbidity (e.g. diabetes, hypertension, pre-eclampsia, eclampsia) * smoking and/or alcohol use * the need for a blood transfusion.

Keywords: niche baseball suturing uterotomy caesarean section
change of regional ventilation during spontaneous breathing after lung surgery

Conditions: Pulmonary Infection; Respiratory Insufficiency; Aspiration Pneumonitis; Bronchospasm; Atelectasis

Summary: perioperative changes in regional ventilation by pulmonary electrical impedance tomography and spirometry will be investigated in patients at risk for postoperative pulmonary complications. those patients undergo lung and flail chest surgery.

postoperative pulmonary complications (defined as pulmonary infection, pleural effusion, atelectasis, pneumothorax, bronchospasm, aspiration pneumonitis or respiratory insufficiency subsequent to surgery) increase the morbidity and mortality of surgical patients. several independent factors determined by the patients' characteristics and the operative procedure increase the risk for those complications. the postoperative decrease of values measured by spirometry, such as the forced vital capacity (fvc) and forced expiratory volume in one second (fev1), were found in patients after major surgical procedures for several days. the postoperative reduction of those measurement can be the result of general functional limitations in those patients (e.g. by postoperative pain) or the result of a regional postoperative pulmonary complication (e.g. atelectasis, pleural effusion). the method of the electrical impedance tomography (eit) enables to visualize the regional ventilation within a transversal section of the lung in real time. studies examining the change of pulmonary eit for several days postoperatively in spontaneously breathing patients are lacking. the aim of the present study is to examine perioperative changes in regional ventilation in spontaneously breathing patients during their recovery after lung and flail chest surgery. moreover, the association of those changes with expected changes in spirometry is tested. finally, in patients with evident postoperative pulmonary complications the value of pulmonary eit to detect those changes is investigated. the study should improve the knowledge about the development of postoperative pulmonary complications and test the scientific and clinical value of pulmonary eit in those spontaneously breathing patients.

Eligibility criteria:
inclusion criteria: * adult * inpatient * lung surgery under general anaesthesia exclusion criteria: * missing informed consent * outpatient * emergency procedure * revision surgery of hospitalized patients * pneumothorax * pleural effusion * pleural effusion or pleural empyema with need to cannulate * scheduled pneumonectomy * expected hospital stay of less than three days * pregnancy * allergy against material of the electrode belt (silicone rubber, stainless steel, gold-plated brass) * injured, inflamed or otherwise affected skin within the target region of the electrode belt * unstable spine injury * body mass index of more than 50 kg/m2 * incapacity to lie quietly for the examination * pacemaker, defibrillator or other active implant * reoperation before the examination at the third postoperative day exclusion criteria during clinical course: * performed pneumonectomy * reoperation * postoperative ventilation at the third day
vocs in patients with acute cardiogenic chest pain

Conditions: Acute Coronary Syndrome; Acute Aortic Syndrome

Summary: the goal of this observation study is to compare vocs in cardiogenic chest pain population/health conditions, to answer：establishment and promotion of the application system of emergency rapid detection of expiratory volatile organic compounds (vocs) in patients with acute cardiogenic chest pain 1. vocs levels were measured at baseline in healthy people, and markers of vocs that could be used to identify acute cardiogenic chest pain were sought. 2. the relationship between abnormal vocs (mainly aldehydes) and prognosis of patients and the correlation with super-score for early warning of acute heart failure.


Eligibility criteria:
inclusion criteria: observation group inclusion criteria: 1. over 18 years old, male or female; 2. patients with acute cardiogenic chest pain (see diagnostic criteria); 3. patient\&#39;s informed consent. inclusion criteria of healthy control group: 1. over 18 years old, male or female; 2. centerless cerebrovascular disease, lung disease, no abnormal liver and kidney function, no acute infection recently; 3. informed consent. exclusion criteria: 1. the patient had difficulty in collecting breath; 2. patients with terminal illness or receiving palliative care; 3. have participated in other clinical studies or consider it inappropriate to participate in this study.
trial of nanopac intratumoral injection in lung cancer

Conditions: Lung Cancer, Nonsmall Cell; Lung Cancer; Lung Cancer, Small Cell; Neoplasm of Lung

Summary: this study evaluates the use of nanopac injected directly into tumors in the lung of people with lung cancer.

nanopac is very small (submicron) particles of the chemotherapy drug, paclitaxel, which is administered intravenously in a number of types of cancer. these submicron particles are injected directly into solid tumors to target cancer at the site of disease with less systemic exposure than intravenously administered chemotherapy. in this study, the submicron particle paclitaxel will be injected directly into tumors in the lungs of people with small cell or non-small cell lung cancer. all subjects in this study will receive nanopac and will be evaluated to see if nanopac is safe and has an effect on the tumor within the lung.

Eligibility criteria:
inclusion criteria: * signed informed consent; * age ≥18 years and able to tolerate the ebus-tbni procedure; * histologically/cytologically confirmed lung cancer. eligible subjects may include, for example: primary or recurrent non-resectable disease, locally advanced stages ii and iii with nodal disease, stage iv advanced disease; * at least one lesion documented via imaging (within 4 weeks of screening) which can be accessed using ebus-tbni; * subject is not a candidate for surgery; * has received or plans to receive soc chemotherapy; adequate hematologic recovery must be confirmed according to the institution's soc; * performance status (ecog) 0-2 at study entry; * life expectancy of at least 6 months; * adequate marrow, liver, and renal function at study entry; * anc ≥ 1.5 x 109/l; * hemoglobin ≥ 9.0 grams/dl; * platelets ≥ 75 x 109/l; * total bilirubin ≤ 1.5x institutional uln; * ast/ alt ≤ 2.5x institutional uln; * creatinine ≤ 1.5x institutional uln; * appropriate steps taken to minimize or avoid the potential for pregnancy for subjects of child-bearing potential.\* exclusion criteria: * significant cardiac disease (class iii or iv per new york heart association guidelines); * active bacterial, viral, or fungal infections (including active aids, hepatitis b or hepatitis c); * symptomatic central nervous system (cns) metastasis which are neurologically unstable, or cns disease requiring increase in steroid dose (treated metastatic disease and stable steroid use are not excluded) * known hypersensitivity to study agent; * pregnant or breastfeeding women.

Keywords: paclitaxel
effect of using educational robots during vaccination on fear and pain in children

Conditions: Fear; Fear of Pain; Pain; Vaccination; Child Behavior

Summary: pain and fear are very common in children during vaccination. we are planning to conduct a study to help children go through this process more comfortably. the aim is to examine whether the educational robot has an effect on pain and fear during vaccination in 4-year-old children in a randomized controlled manner.

data collection method: a sample group of 74 people will be divided into two groups using www.randomizer.org using a simple randomization method. intervention group: the child patients in this group will be given the opportunity to get to know, touch and examine the educational mini robot for 5 minutes before the dabt-ipa vaccination. the robot will attract the child's attention. during this time, the sociodemographic data form will be filled. at the end of the 5th minute, the child patient will prepare the vaccination with the cooperation of the staff and parents. during this time, the researcher will maintain the child's relationship with the robot and ensure that he/she focuses his/her attention on the robot. the application will end after the dabt-ipa vaccination process. 5 minutes after the procedure, the child fear scale (çkö, wong baker pain scale) will be filled by the researcher using a face-to-face interview technique. the robot will be cleaned with antiseptic solution after each child patient. control group: after the procedure is explained according to the child's developmental level, the dabt-i̇pa vaccine will be administered in accordance with the institution's policies. 5 minutes later, the sociodemographic data form, child fear scale (çkö, wong baker pain scale) will be filled by the researcher using a face-to-face interview technique. at the end of the data collection, the control group will be provided with the opportunity to spend time with the robot in order to be beneficial.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the study * the child must be 4 years old * must have come to a primary care center in balıkesir city center * dabt-i̇pa vaccination must be administered * vastus lateralis muscle must be used in vaccination exclusion criteria: * not volunteering to participate in the study * the child is not 4 years old * he/she has not come to a family health center in balıkesir city center * dabt-i̇pa vaccination is not applied * vastus lateralis muscle will not be used in vaccination application

Keywords: pain fear vaccination child behavior