Kornimate/medical-research-clean huggingface dataset:
impact of pharmaceutical care in diabetics patients

Conditions: Diabetes Mellitus Type 2

Summary: the monitoring of diabetics by the pharmacist may contribute to the effectiveness of drug treatment and to improve their quality of life. this study will measure the impact of pharmacotherapeutic follow-up in diabetic patients. this will be a clinical trial, single blind, controlled, randomized, conducted in two units of pharmacies in brazil. only in the intervention group will be held the pharmacotherapeutic follow using a methodology called the practice of pharmaceutical care, which identifies and resolves problems related to drugs. the primary outcome is glycated hemoglobin, and secondary outcomes are baseline glucose, total cholesterol and its fractions (for example ldl), all these measures will be made in the intervention group and control group. patients will be followed for 24 weeks, and the outcomes will be assessed up to 24 weeks. there will be a confidence interval of 95% and a significance of p \<0.05, and will use the student t test, chi-square analysis of variance (anova) and others if necessary. expects good results and serve as a model for other researchers.


Eligibility criteria:
inclusion criteria:inclusion criteria: * patients aged 30 years, * diagnosed with type 2 diabetes, * to make use of oral antidiabetic agents with or without insulin exclusion criteria: those who had infectious diseases during the research * missed three consecutive interviews, * suspended the hypoglycemic drug and medical order

Keywords: pharmaceutical care diabetics patients clinical trial
treatment of tennis elbow with botulinum toxin

Conditions: Epicondylitis, Lateral Humeral

Summary: the purpose of this study is to determine whether botulinum a toxin is effective in the treatment of tennis elbow (lateral epicondylitis).

tennis elbow (lateral epicondylitis) is a common cause of chronic elbow pain and wrist extensor dysfunction in adults, affecting 1% to 3% of the general population per year. there is currently no consensus on its optimal treatment with wide-ranging options available. the best available scientific evidence suggests that only topical non-steroidal anti-inflammatory drugs and possibly, oral non-steroidal anti-inflammatory drugs may be useful for short term pain relief, while corticosteroid injections presented both benefits and harms as a short term measure. botulinum toxin has been reported in the treatment of lateral epicondylitis with promising results but these studies lack a control group bringing up the question whether recovery was a result of intervention or the natural history of the disease. method: a twin-center, prospective, randomized, double-blind, placebo-controlled trial in which all patients received either a botulinum injection or a placebo saline injection. consecutive patients over 18 years old with tennis elbow referred to the outpatient clinic at the investigators' institution will be screened for this study. eligible patients will be invited to participate in the study.

Eligibility criteria:
inclusion criteria: * patients aged 18 years and up * pain at the lateral side of the elbow * pain at the lateral epicondyle during resisted dorsiflexion of the wrist with the elbow in full extension * pain for longer than 3 months exclusion criteria: * previous operations (including previous steroid injections for the disorder) * nerve entrapment * pregnancy and while breast-feeding * presence of systemic neuromuscular disorders such as myasthenia gravis
stereotactic non-invasive ablation of ventricular tachycardia

Conditions: Ventricular Tachycardia

Summary: stereotactic ablative radiosurgery of recurrent ventricular tachycardia in structural heart disease (star-vt).

the goal of this project is to evaluate feasibility and safety/toxicity of elimination of ventricular tachycardia (vt) associated with structural heart disease by noninvasive strategy, stereotactic radiosurgical ablation in an indication of bail-out procedure after failed catheter ablation. the arrhythmogenic substrate will be identified by imaging techniques and functionally by electroanatomic mapping and pacing. the recipients of stereotactic surgery will be patients after 2 unsuccessful catheter ablations for monomorphic vts (one of the procedures will be performed in an expert center). the target volume for stereotactic radiosurgical ablation (single dose of 25 gy) will be a critical region of the substrate defined by a combination of imaging and functional methods with an export of the merged image-electroanatomical map into the radiosurgery planning console. primary endpoints will be a reduction of the burden of sustained vt, time to death or arrhythmic storm or appropriate therapy with implantable cardioverter-defibrillator (icd) for isolated vt and/or time do development of radiation toxicity (both acute and late).

Eligibility criteria:
inclusion criteria: * patients with structural heart disease (ischemic and non-ischemic cardiomyopathy, previous surgery for congenital heart disease) * implanted icd or crt-d (cardiac resynchronization therapy defibrillator) * prior ≥1 catheter ablation procedure for monomorphic vt * vt recurrence early (\<12 months) after the last ablation with at least 2 episodes of recurrent vt, including 1 episode while on amiodarone (if not contraindicated) * age ≥30 years * signed an irb-approved (institutional review board) written informed consent exclusion criteria: * acute myocardial infarction or recent percutaneous coronary intervention (pci) or cardiac surgery (\<3 months) * primary electrical disease (channelopathy) * reversible cause of vt (e.g. drug-induced, intoxications, etc) * pregnancy or breastfeeding * chronic heart failure new york heart association (nyha) class iv * serious comorbidities with presumed life expectancy less than one year * significant peripheral artery disease precluding retrograde aortic mapping * history of chest radiotherapy

Keywords: structural heart disease ventricular tachycardia substrate ablation stereotactic radiosurgery functional radiosurgery 4d navigation
synbiotics for the management of malnutrition (children)

Conditions: Severe Acute Malnutrition

Summary: in this study, dose related effect of synbiotics on the blood indices of severely acute malnourished (sam) children (6-59 months) was carried out in hospitalized setting. fifty sam children were enrolled in a double-blind, randomized design.

the study was done at nutrition rehabilitation unit (nru), department of social \& preventive pediatrics, mayo hospital, lahore, pakistan, a tertiary care large urban teaching and referral hospital and was approved by human ethics institutional review board (irb) .galacto-oligosaccharides (oligomate) as prebiotics were procured from yakult pharmaceutical industry, japan and resiton (lactobacillus paracasei subsp. paracasei) as probiotics were procured from maknsons pharmaceutical industry, italy. in the present study we enrolled 50 severely acute malnourished (sam) in patients of 6-59 months of age while follow-up treatment was given at the out-patient department. we define sam as weight-for height of less than 70% of the median, nutritional edema (kwashiorkor), or both, mid-upper arm circumference (muac) of less than 11.5cm. anthropometry protocols were followed by research standards

Eligibility criteria:
inclusion criteria: * in the present study we enrolled 50 severely acute malnourished (sam) patients of 6-59 months of age while follow-up treatment was given at the out-patient department. * patients having weight-for-height of less than 70% of the median, nutritional edema (kwashiorkor), or both, * mid-upper arm circumference (muac) of less than 11.5cm exclusion criteria: * participant taking other supplements or enrolled in other studies
colonoscopic adenoma and advanced neoplasia detection rates according to age

Conditions: Colonic Polyp; Colon Adenoma; Colonoscopy; Colon Cancer; Age

Summary: current recommendations for colonoscopy screening programs usually involve patients older than 50 years of age. however, little is known about polyp or adenoma detection rates under 50. we compared these detection rates according to age in a large series of patients in common practice. methods: all colonoscopies performed in 2016 in our unit were prospectively recorded. we determined adenoma detection rate (adr), polyp detection rate (pdr), mean number of polyps (mnp), and advanced neoplasia detection rate (andr).

patients all consecutive patients who were scheduled for colonoscopy were included. exclusion criteria were: patients scheduled for partial colonoscopy, interventional colonoscopy (for stent insertion, stenosis dilation). data collection the following data have been prospectively collected: age, gender, indication for colonoscopy, preparation procedure and quality of the preparation (assessed by the boston bowel preparation scale; bbps) \[19-20\], caecal intubation (yes/no), withdrawal time, number and size of polyps and polyp histopathology. all clinical data were collected during the procedure by a nurse and an endoscopist on a dedicated software. the database was then supplemented by the clinical research associate for histopathological data. we determined adenoma detection rate (adr; percentage of colonoscopies with at least one adenoma), polyp detection rate (pdr: percentage of colonoscopies with at least one polyp), mean number of polyps per colonoscopy (mnp), large polyp detection rate (lpdr; percentage of colonoscopies with at least one polyp of 1 cm or more) and advanced neoplasia detection rate (andr: percentage of colonoscopies with at least one advanced neoplastic lesion as defined below).

Eligibility criteria:
inclusion criteria: * all consecutive patients who were scheduled for colonoscopy were included. exclusion criteria: * patients scheduled for partial colonoscopy, interventional colonoscopy (for stent insertion, stenosis dilation).
group a streptococcus

Conditions: Streptococcal Pharyngitis

Summary: the purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.

the overall objective of this investigation is to understand the differences in group a streptococci in children who are acutely infected from those who are carriers. the hypothesis is that when in the carrier state, gas exhibits unique transcriptional profiles that differ from those of the acute infection state. the investigators expect transcriptional profiles of gas to provide important information regarding the changes the organism undergoes when transitioning between acute infection and carriage. the specific aims of this study are: 1. to collect longitudinal participant-samples from acute and carriage phases of gas infection and compare transcriptomic profiles and whole genome sequences of gas recovered from acute and carrier pharyngeal swabs obtained from the same participants. 2. to evaluate how identified differentially expressed genes, or observed genetic polymorphisms, influence gas models of bacterial colonization and pathogenesis. to do this, the investigators will to identify 12 children with acute pharyngitis due to group a streptococcus (gas) who are pharyngeal carriers of gas. thirty percent of children 4 to 16 years of age with acute pharyngitis occurring between october and may will have a positive culture or rapid antigen detection test for gas. approximately 8-10% of these children with pharyngitis and a positive culture or rapid antigen detection test (radt) for gas will be carriers. therefore,180 participants will need to be enrolled.

Eligibility criteria:
inclusion criteria: * children ages 5-15 years * positive rapid antigen detection test for group a streptococcus * parent or legal guardian present and able to provide consent * provider prescribes treatment with a beta lactam antibiotic * english speaking exclusion criteria: * unable to take beta lactam antibiotics * other concurrent bacterial infection, i.e., pneumonia

Keywords: streptococcus pyogenes streptococcus
german translation and cross-cultural adaptation of the headache screening questionnaire (hsq) followed by a test-retest reliability study.

Conditions: Migraine; Tension-Type Headache

Summary: the goal of this study is to learn more about the headache screening questionnaire in people with headache. the main question is: does the lower limit of a 95% confidence interval of the hsq in physiotherapy during a period of 2 to 4 weeks reach at least 0.4?

data are collected using the redcap web application (https://redcap.zhaw.ch/). redcap is designed for the creation and administration of online surveys. respondents can access the survey directly via a qr code or link and complete the screening questionnaire via smartphone or computer. in a first step, the participating persons are included or excluded based on the criteria mentioned (chapter: proband:innen). once eligibility has been confirmed, the hsq is completed online for the first time in a second step. after that, the test persons will receive a reminder e-mail after 2 weeks to complete the retest online. after the reminder email the test persons have 2 weeks to complete the retest. those who participate later will be excluded and not included in the data analysis. in addition, the retest asks whether the headaches have changed compared to the test due to the physiotherapeutic treatment. this is asked with a three likert scale (not changed, slightly changed, strongly changed). the severely changed headaches are not included in the analysis. translated with www.deepl.com/translator (free version)

Eligibility criteria:
inclusion criteria: * individuals who are older than 18 years, * live in switzerland * speak and understand german * have had multiple headache episodes of the same or similar type exclusion criteria: * individuals with other known neurological conditions, * known cognitive impairment * known secondary headache types
the lake nona life project

Conditions: Health Behavior; Quality of Life; Aging

Summary: the lake nona life project aims to examine the health and wellness of participants over the course of multiple years, focusing on the links between health and wellness, longevity, quality of life, and human performance.

the lake nona life project is a community health and wellness research project of the lake nona institute (lni), carried out by the lake nona medical city residents and partners (the researchers), and sponsored by florida hospital. the project is designed to study patterns, predictors and strategies for improving human health and wellness. data will be obtained over many years using surveys/interviews, medical tests, and health information from 3rd parties (i.e., health care claims data) obtained with participant permission.

Eligibility criteria:
inclusion criteria: * 18 years or older * live and/or work in the lake nona community (proper) * able to provide informed consent * able to speak and read english exclusion criteria: * unable to speak or communicate in english * living outside of the lnlp study map * cognitive impairment that would not allow survey completion * unable to speak and read english

Keywords: health wellness life expectancy quality of life performance religion skin cardiovascular joints bone respiration pain nervous system diseases oral health behavior child depression mood panic sleep stress nutrition exercise life change events personality employment social networking time management residence characteristics
npd measurement in infants

Conditions: Cystic Fibrosis

Summary: nasal potential difference measurements (npd) have been performed in israel since 1996. npd measurements are used to assess the voltage across nasal epithelium, which correlates with the transport of sodium and chloride across cell membranes. npd was first demonstrated to be abnormal in cystic fibrosis (cf) in 1981 and the technique has since been used to increase our understanding of this condition. it is now established as an important diagnostic tool and more recently has been used to assess the effectiveness of new treatments such as gene and alternative therapy (knowles 1995; wilschanski 2003). the nasal cavity is accessible which makes it a good site to examine the ion transport characteristics of airway epithelia. less than a centimetre into the nose the squamous ("skin type") epithelium becomes ciliated pseudocolumnar epithelium, characteristic of the proximal airways. the change in npd with the perfusion of different solutions is demonstrated. by employing npd protocols with perfusion of different solutions and drugs, different aspects of the nasal ion transport characteristics can be examined. in cf, this ion transport profile is abnormal and the npd measurement has a number of features that differentiate cf from non-cf. this methodology is well established for measurements in subjects over 6 years of age. measurements on smaller children and infants have been very difficult to perform. we propose a new method using smaller, single lumen catheters with much lower perfusion rates (0.2 ml/min compared to up to 5 ml/min with the adult method) .perfusion measurements will be possible in newly born infants. obviously this opens up the potential for using npd as a diagnostic test in babies. this is important as the diagnosis of cf is often difficult to make or refute in babies because of the problems in collecting enough sweat. this may be the ideal diagnostic test for cf in the neonatal nursery in infants with meconium plug syndrome.


Eligibility criteria:
inclusion criteria: * age below 6 years * patients who suspected for cf due to pulmonary and/or gastrointestinal symptoms exclusion criteria: * age over 6 years

Keywords: nasal potential difference
development of a neurocognitive screening test

Conditions: Brain Concussion; Mild Cognitive Impairment

Summary: this research study will evaluate a standalone software application and is designed to standardize and validate new neurocognitive screening testing for children aged 6 through 11, and adolescents and adults ages 12 through 75. the purpose of this study is to evaluate recently developed computerized tasks sensitive to changes in neurocognitive performance after a concussion. these tests were designed to help measure the effects of concussion on cognitive processes (e.g., memory, attention, brain speed) and visual functioning.


Eligibility criteria:
inclusion criteria: * age: 12-75 (adult version), 6-11 (pediatric version) * primary english speaking or fluent in english. * no known special education diagnosis excluding a 504 designation. * currently not suffering from a concussion or being treated for a concussion.\* * no known physical or psychological impairment that would affect their ability to perform the test. exclusion criteria: * documentation of a known special education diagnosis other than a 504 designation. * english is not their primary language nor are they proficient in the english language. * currently suffering from a concussion or being treated for a concussion.\* * any known physical or psychological impairment that would affect their ability to perform the test. * note: unless specifically required by the particular study (i.e., a discriminant validity study differentiating concussed versus non-concussed individuals).
evaluation of standard and robot assisted total knee arthroplasty with a bicrucatie retaining prosthesis

Conditions: Osteo Arthritis Knee

Summary: the first study goal is to compare the outcomes between posterior stabilized and bicruciate retaining tka. additionally, the second goal is to evaluate the effect of robot assisted surgery in both posterior stabilized and bicruciate retaining tka.


Eligibility criteria:
inclusion criteria: * end stage osteoarthritis of the knee joint with failed conservative treatment exclusion criteria: * previous ligament trauma * previous fracture of femur or tibia * fixed flexion contracture \> 10° * flexion \< 110° * coronal deformity \> 15° * previous infection of the knee joint * ligament insufficiency * neurologic conditions

Keywords: total knee arthroplasty robot
acupuncture in fibromyalgia

Conditions: Fibromyalgia; Pain

Summary: fibromyalgia is the second most common rheumatic disorder, affecting approximately 8-10 million persons in the u.s., and is characterized by widespread musculoskeletal pain and soft tissue tenderness upon examination. this study focuses on the use of acupuncture as a mode of therapy for fibromyalgia. the issues under examination are: 1) the optimal duration of treatment, 2) the independent and synergistic effects of needle placement and needle stimulation, and 3) appropriate control strategies. the proposal utilizes a randomized, blinded, sham-controlled design to achieve these aims. subjects are randomly assigned to one of four groups: 1)active site with stimulation, 2) active site, without stimulation, 3) sham site with stimulation, and 4) sham site, without stimulation. all subjects will receive acupuncture at escalating frequency, beginning at once per week and ending at 3 times per week. this "forced titration" design allows for the detection of inter-subject differences in responsiveness to acupuncture, as well as the factors which may predict responsiveness (or lack thereof). secondary goals of the study are to collect data on the mechanism, safety, and cost-effectiveness of acupuncture in fibromyalgia, and to determine the optimal outcome measures, for a full scale research clinical trial.


Eligibility criteria:
inclusion criteria: * must be a resident of the washington dc area. * having met acr criteria for fibromyalgia. * continued widespread pain for more than 50% of days. * willing to limit the introduction of any new medications or treatment modalities for control of fibromyalgia symptoms during the 13 weeks of active treatment. * able to travel to acupuncture site up to 3 times per week. * capable of giving informed consent. exclusion criteria: * knowledge of acupuncture sufficient to prevent "blinding" of the subject. * presence of a known coagulation abnormality that would prevent safe use of acupuncture. * presence of a concurrent autoimmune or inflammatory disease that causes pain. * routine daily use of narcotic analgesics or history of substance abuse. * participation in other concurrent therapeutic trials. * pregnant or nursing mothers. * disability insurance payments. * ongoing litigation related to fibromyalgia. * contraindication for the use of acetaminophen or ibuprofen. * any impairment, activity, or situation that in the judgement of the study coordinator would prevent satisfactory completion of the study protocol.

Keywords: acupuncture fibromyalgia pain analgesia