Kornimate/medical-research-clean huggingface dataset:
effects of manual ic with and without scs on scm tightness with fhp

Conditions: Neck Pain

Summary: the aim of this study is to compare the effects of manual ischemic compression with and without strain counterstrain technique on cva, rom, pain and disability among fhp individuals with scm tightness.

forward head posture is defined by excessive extension at upper cervical spine(c1-c3) and flexion at lower cervical spine (c4-c7) that increases cranial rotation angle and decreases craniovertebral angle (cva) because of the altered relative position of the head with respect to the line of gravity. the bubble inclinometer is a gravity-based tool used to measure the cervical range of motion and to assess scm muscle length. fhp also leads to muscles imbalance and scm tightness as well. the numerical pain rating scale (nprs) are most frequently used to quantify pain intensity and ndi for neck disability. a rct study compare the effects of ic and scs in patients with upper trapezius trigger points. for four weeks, the therapy was given three days a week. as an outcome indicator, the nprs, ndi, and cervical lateral flexion were used. the outcome measures were evaluated at baseline, after the second week, and after the fourth week: the ischemic compression and strain counterstrain intervention, which lasted for four weeks, significantly improved cervical range of motion, reduced pain intensity, and reduced cervical disability. however, the intergroup comparison revealed that both interventions were equally effective, and none of them outperformed the others. most of the studies compared digital ischemic compression as a common treatment with dry needling or other soft tissue mobilizations specially to treat trapezius trigger points but there are few studies specifically investigating comparative effects of manual ischemic compression with and without strain counterstrain for management purpose of muscle tightness in individuals with fhp. while various treatment options exist for fhp, limited research directly compares the comparative outcomes of strain counterstrain and ischemic compression techniques. due to lack of comparative evidence regarding the efficacy of these specific interventions, there is a need to bridge this gap by investigating and comparing the effectiveness of these interventions by using highly reliable and valid outcome measures in order to provide healthcare professionals and individuals with evidence-based guidance for optimal fhp management and scm tightness.

Eligibility criteria:
inclusion criteria: * neck pain (numeric pain rating scale \>3) * craniovertebral angle (cva) less than 51 * shortened scm muscle exclusion criteria: * neck pain with whiplash or headache, neurological disorder * history of previous head, neck, cervical spine or shoulder surgery * infection or inflammatory arthritis in the cervical spine * history of cervical radiculopathy * diagnosed fibromyalgia and myopathy * history of cancer

Keywords: disability forward head posture pain rom sternocleidomastoid
sex and gender differences in ischemic heart disease - endocrine vascular disease approach

Conditions: Myocardial Ischemia

Summary: the application of sex-gender medicine is strongly recommended by world health organization and other international organization. in fact, it is emerging that, although men and women are affected to the same cardiovascular diseases (cvd), however they have different risk factors, disease progression and response to pharmacological and not-pharmacological treatments. consequentially, the identification of biomarkers and therapeutic approaches taking into account sex gender differences (sgd) is relevant to develop a really evidence-based medicine. with the aim of translate in clinical setting the more recently available basic research evidences on estrogens and androgens balance involvement in modulation of ischemia-reperfusion myocardial damage, the investigators planned to conduct a research study on patients, affected by suspected or known ischemic heart disease (ihd) undergoing angiography and/or percutaneous coronary interventions (pci), aged more than 18 years of both sex in ratio 1:1. thus, in this setting, the goals of this proposal are: 1. to assess the sex-gender difference in entity of microvascular reperfusion damage in patients with ihd undergoing urgent or elective pci; 2. to evaluate estrogen/androgen-dependent and -independent effects in gender-related differences on myocardial ischemia reperfusion damage occurring during pci; 3. to investigate the differences in terms of platelet biology between men and women affected by ihd undergoing urgent or elective pci, matched for age and clinical cardiovascular and metabolic characteristics; 4. to verify sex-driven interplay between response to pci procedure, platelet function, sex hormones and entity of reperfusion and myocardial damage, as well as, the impact on clinical outcomes during a 1-year follow up. this research study wants to explore and consequently elucidate biological mechanisms responsible for sex-based differences in vivo human models of ischemia reperfusion myocardial damage. moreover, the investigators expected to clarify the impact of biological variables evaluated on clinical outcomes after reperfusion therapeutic intervention.


Eligibility criteria:
inclusion criteria: * patients with ischemic heart disease (acute or chronic) undergoing percutaneous coronary intervention (urgent or elective) * written informed consent * both sex * aged more than 18 years exclusion criteria: * patients with expectancy of life less than 12 months * active cancer * pregnancy

Keywords: coronary heart disease gender platelet microvascular dysfunction sexual hormones cardiac magnetic resonance percutaneous coronary interventions
safety and efficacy of insulin detemir plus insulin aspart against insulin glargine plus insulin aspart as mealtime insulin in type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial is conducted in europe and the united states of america (usa). the purpose of this study is to test whether insulin detemir is a safe and at least as effective alternative to insulin glargine for the control of blood glucose in basal/bolus therapy in patients with type i diabetes.


Eligibility criteria:
inclusion criteria: * type 1 diabetes for at least 12 months * current treatment with basal-bolus insulin regimen for more than or equal to 3 months * hba1c less than or equal to 11.0% exclusion criteria: * proliferative retinopathy or maculopathy * recurrent major hypoglycaemia * impaired hepatic or renal function * cardiac problems or uncontrolled hypertension

Keywords: diabetes mellitus, type i
clinical evaluation of lyral® dose response study

Conditions: Contact Dermatitis

Summary: the purpose of this study is to determine optimal allergen dose as the lowest concentration eliciting positive reactions in 70-90% of subjects. frequency of positive, negative, doubtful and irritant reactions, and concordance with a corresponding reference allergens will be captured.

this is a single-center, randomized study to compare the diagnostic performance and safety of ascending doses (0.10 mg/cm², 0.20 mg/cm² and 0.40 mg/cm²) of hydroxyisohexyl 3-cyclohexene carboxaldehyde (lyral®) in 20 adult subjects with a past positive patch test to lyral® or fragrance mix 2.

Eligibility criteria:
inclusion criteria: 1. males and females 18 years of age and older. 2. clinical history of contact dermatitis and positive patch test (current or previous) to either lyral® or fragrance mix 2; otherwise in good general health. 3. unable to become pregnant or willing to use an acceptable method of contraception to prevent pregnancy if female of childbearing potential; inability to become pregnant would include all male subjects and female subjects who are postmenopausal for at least 1 year, or surgically sterile- have had a hysterectomy, bilateral ovariectomy, uterine ablation or bilateral tubal ligation. acceptable methods of contraception include: 1) systemic birth control (the same type of birth control for at least 3 months prior to entering the study and continuation of this type of birth control throughout the study); 2) double barrier methods (condom with spermicide or diaphragm with spermicide); 3) intra uterine device; 4) vasectomized partner; or 5) abstinence from sexual intercourse. 4. have read and signed the consent form and are able to fulfill the study requirements and make all required visits. exclusion criteria: 1. lactation or pregnancy, determined by urine pregnancy test (upt) for females of childbearing potential. upt must be conducted prior to patch placement. 2. treatment with topical corticosteroids on or near the test area during the previous 7 days. 3. treatment with systemic corticosteroids or immunosuppressives during the previous 7 days. (inhaled treatments are permitted.) 4. treatment with ultraviolet (uv) light, including tanning, during the previous 3 weeks. 5. acute dermatitis outbreak or dermatitis on or near the test area on the back. 6. participation in another clinical study involving an investigational drug, treatment or device currently or within the previous 3 weeks. 7. unable to comply with activity restrictions (e.g., protecting test panels from excess moisture due to showering or vigorous activity). 8. unable or unwilling to comply with multiple return visits.

Keywords: patch test allergy testing contact dermatitis lyral allergen fragrance mix allergen
a prospective registry study in patients with unresectable locally advanced or metastatic breast cancer (mbc)

Conditions: Breast Neoplasms

Summary: this study is a prospective, multicenter non-interventional cohort study designed to develop a registry in unresectable locally advanced or metastatic disease.

the target population for inclusion in this study is breast cancer patients recently diagnosed (from january 2016) with unresectable locally advanced or metastatic disease (either after a recurrence or as first diagnosis). no treatment regimen will be protocol specified. this is an observational study in which clinical decisions concerning the optimum management strategy for a particular patient are taken independently of and/or prior to, any decision by the physician to invite a patient to participate in the study. the treating physician will make all treatment decisions according to his/her regular clinical practice independent of this study. patients enrolled on the study are free to withdraw their informed consent for the use and disclosure of health information at any time and when asked, patients are not obliged to provide a reason. patients may request discontinuation from the study at any time. the date and the reason for withdrawal or discontinuation from the study must be recorded in the electronic case report form (ecrf). an attempt will be made to determine the date of discontinuation and final status (i. e. withdrawal of consent, loss to follow-up, death) of any patient who discontinues from the study. however, the treating clinician is encouraged to follow the patient as long as possible, until patient death or through study end. the sponsor has the right to terminate the study at any time. the sponsor will notify the investigator if the study is placed on hold or if the sponsor decides to discontinue the study.

Eligibility criteria:
inclusion criteria: 1. patients (males or females) diagnosed with unresectable locally advanced or mbc (either after a recurrence or as first diagnosis) from january 2016 onwards. 2. patients who died are allowed to be included on the study. 3. able and willing to provide written informed consent if they are alive. 4. age ≥ 18 years. 5. availability to medical records access and all data related to the disease management. exclusion criteria: none

Keywords: unresectable locally advanced metastatic disease
hfnc and ncpap in extremely preterm infants

Conditions: Extreme Prematurity

Summary: to avoid or decrease the rate of complications in preterm infants after disconnection from a mechanical ventilation (extubation), non-invasive respiratory support is routinely used. while infants are most commonly extubated to nasal continuous positive airway pressure (ncpap), high flow nasal cannula (hfnc) has emerged as an attractive alternative. however, research regarding the safety and efficacy of hfnc in the most extreme preterm infants is limited. therefore, we hypothesize that immediately after extubation, measures of heart rate and respiratory behavior may be useful to investigate for any differences between hfnc and ncpap.

infants will be studied 30 min after extubation on both modes of support, provided in a random order. a transition period of 15 min between modes will be given. for each mode, recordings will be performed for 40 minutes. analysis of these recordings will be done off line.

Eligibility criteria:
inclusion criteria: * infants with birth weight ≤ 1250 grams * infants that have been mechanically ventilated and undergoing their first elective extubation attempt exclusion criteria: * major congenital anomalies, neuromuscular disease, hemodynamic instability (use of vasopressors or hypotension). * infants reintubated before initiation or during data collection. * parental/legal guardian consent not obtained.

Keywords: ncpap hfnc preterm infants cardiorespiratory behaviour non-invasive respiratory support
remote tai ji for low back pain

Conditions: Low Back Pain

Summary: the purpose of the study is to examine the implementation strategy, in terms of feasibility and the possible benefits, of a free online zoom t'ai chi and qigong gentle movement and meditation program to reduce back pain and to improve sleep and quality of life among those with chronic back pain. the primary objective of this study is to examine whether a safe and moderate online t'ai chi and qigong exercise program, offered without cost to individuals with chronic back pain, improves pain levels, sleep, and quality of life; the secondary objective is to explore whether improvements in pain levels are different among smokers and those with unhealthy bmi than among others.


Eligibility criteria:
inclusion criteria: * 18 years and older * have experienced low back pain for the last 6 weeks or longer * understands written and spoken english * be willing to complete the initial survey and 3 additional ones emailed baseline and january 2023 * be willing and able to provide consent to participate in the survey exclusion criteria: * pregnany * previously has taken t'ai chi classes * spine surgery within the last 6 months

Keywords: tai chi qigong
question prompt list in breast cancer patients planned for neoadjuvant chemotherapy

Conditions: Breast Cancer Early Stage Breast Cancer (Stage 1-3); Neoadjuvant Therapy; Shared Decision Making

Summary: preoperative chemotherapy has been shown to be at least as effective as postoperative chemotherapy in breast cancer patients and has seen increased use over time. the decision regarding neoadjuvant treatment is complex, as various aspects need to be considered, and the patient's role in the decision-making process is central. the information provided by doctors to patients about preoperative treatment can be complicated, including details about treatment options, treatment plans, and side effects. if this information is not conveyed adequately, there is a risk of misunderstandings, which can lead to increased anxiety and stress for patients regarding their decisions. in oncology, question prompt lists (qpl) have been used as a tool to support patients by improving the information conveyed by doctors in various contexts where complex decisions need to be made. studies have shown that qpl can facilitate better information exchange. however, their use in discussions about preoperative treatment for breast cancer patients has not been studied. furthermore, evidence from randomized studies on the use of qpl in clinical practice is very limited. the aim of this study is to investigate whether the use of qpl during patient consultations involving discussions about neoadjuvant chemotherapy can improve information exchange in various aspects: understanding of the treatment; anxiety about the decision; participation in the decision-making process; patient-doctor communication; and decision-related conflict.


Eligibility criteria:
inclusion criteria: * patients with operable breast cancer eligible for systemic neoadjuvant therapy, according to current treatment guidelines. exclusion criteria: * patients with locally advanced breast cancer where neoadjuvant therapy is mandatory rather than a treatment option. * patients with cognitive impairment that are assessed from treating physician as unable to participate. * patients who cannot speak/read neither swedish nor english.

Keywords: breast cancer neoadjuvant therapy question prompt list patient-physician communication shared decision making
parenting program to enhance preterm infants' health and development (prepare trial)

Conditions: Behavioral Assessment of Children; Early Intervention

Summary: preterm infants are at high risk of developmental delay or disabilities and they do benefit from early intervention programs. many programs aiming at improving preterm infants' developmental outcome have been proposed with mixed results. in low to middle-income countries, clinically relevant and effective low cost interventions empowering parents have yet to be established.

education and intervention programs targeting parents of premature infants are lacking in low to middle income countries (lmic) and in arabic countries in particular. the main concept of this proposal is to develop a program in arabic for parents of premature infants with the aim to increase their knowledge about short and long term problems of prematurity, increase their involvement in the care during their stay in the neonatal intensive care unit (nicu) and promote responsive and sensitive parenting in the nicu and after discharge. this is to empower parents and have them become active contributors to enhancing their infant's development through play activities and tracking of developmental milestones.

Eligibility criteria:
inclusion criteria: * couplets of parents and their preterm infants admitted to the nicu, who are \<35 weeks gestation at birth and who are deemed medically stable by their treating neonatologist. exclusion criteria: * infants with significant neurologic disorder precluding meaningful interaction with the parents as determined by the neurologist * infants with major congenital anomalies precluding meaningful interaction with the parents as determined by the neurologist * infants with systemic medical and/ or surgical conditions precluding interaction with the parents, other than preterm-related intraventricular hemorrhage (ivh) and periventricular leukomalacia (pvl). * parental refusal to participate * absence of clearance from the neonatologist * infants planned to be transferred to another facility for their nicu care.

Keywords: preterm infant parental stress early child development parenting in the neonatal intensive care
bmp-2 and alp levels following laser therapy with scaling and root planing in periodontitis- rct.

Conditions: Periodontitis, Laser

Summary: patients with periodontitis will be treated by either srp only or srp in combination with laser. samples from gcf will be collected immediately after treatment and at 3 months follow-up time. levels of bmp-2 and alp will be assessed at these time points. statistical analysis to compare the results will be performed.


Eligibility criteria:
inclusion criteria: * periodontitis exclusion criteria: * uncontrolled medical condition
trial of spirometry fundamentals™ in the primary care setting

Conditions: Asthma

Summary: spirometry is a recommended component of asthma diagnosis and treatment in the primary care setting, yet few primary care providers report routine use of spirometry in the provision of care for their asthma patients. misclassification of asthma severity has been reported when assessment is based on symptoms alone. this misclassification can lead to inadequate treatment that may result in increased morbidity and increased healthcare utilization/cost. however, even when spirometry is utilized to aid in asthma severity classification, primary care providers have a high rate of failing to meet the quality goals for testing established by the american thoracic society. the goal of this study is to evaluate the effectiveness of the spirometry fundamentals™ tool in training primary care providers and their staff in producing high-quality flow-volume curves as compared to existing training modalities and to gather information in a 'real-world' setting that can be used to improve spirometry fundamentals™.

currently few self-paced, distance learning programs exist that train staff to perform good quality spirometry tests. this study evaluates the effectiveness of a distance-learning tool for training primary care providers and their medical assistants in the use of spirometry to assist in managing obstructive lung disease (asthma and copd). this tool is called "spirometry fundamentals™: a basic guide to lung function testing". it is a computer-based training program that teaches primary care providers and their staff what spirometry is, how it can be used, the techniques required to perform high-quality spirometry, and clinical interpretation of the spirometric data. we evaluated the effectiveness of spirometry fundamentals in the primary care setting by conducting a randomized controlled trial (rct). study participants were primary care physicians (mds or dos) and their staff (medical assistants (mas) or nurses (rns)) and were recruited as study pairs. the role of the mds was to utilize spirometry in clinical care by ordering spirometry tests based on their clinical judgment, and the role of the mas was to perform the spirometry. the patients performed the spirometry as part of their usual care were not considered study subjects.

Eligibility criteria:
inclusion criteria: * subjects must have internet access in order to transmit spirometry curve and survey data. * subjects must have access to a computer with windows 2000 /mac os 10 or higher in order to view spirometry fundamentals™. * subjects must have access to a ndd easyone spirometer. exclusion criteria: * subjects who lack internet access which will be needed to transmit study data * subjects who lack access to a computer with windows 2000 /mac os 10 or higher which will be needed to view spirometry fundamentals™. * subjects who lack access to a ndd easyone spirometer.

Keywords: asthma spirometry pediatric primary health care education, distance