Kornimate/medical-research-clean huggingface dataset:
a safety and efficacy study of prograf in the prevention of erectile dysfunction after radical prostatectomy

Conditions: Erectile Dysfunction; Prostate Cancer

Summary: the purpose of the study is to compare the safety and effectiveness of prograf in the prevention of erectile dysfunction in men after a radical prostatectomy.

the purpose of the study is to compare the safety and efficacy of prograf versus placebo in the prevention of erectile dysfunction in men after a bilateral nerve-sparing radical prostatectomy.

Eligibility criteria:
inclusion criteria: * male scheduled to undergo bilateral nerve sparing radical prostatectomy for prostate cancer. exclusion criteria: * patient is \> 65 years of age * patient has been diagnosed with type 1 or type 2 diabetes * patient is actively smoking on a daily basis

Keywords: treatment effectiveness treatment efficacy investigational, therapies immunosuppressant erectile dysfunction prostatectomy
effect of an online video-based intervention to increase hiv testing in men who have sex with men in peru

Conditions: HIV Infections

Summary: men who have sex with men (msm) account for the greatest burden of the hiv and sexually transmitted infection (sti) epidemic in peru. current interventions that promote early identification and treatment of these diseases target a limited number of this population because they rely solely on peer education. to assess the use of the internet as an alternative tool to reach this population the investigators propose to conduct an online randomized controlled trial to compare the effect of hiv-testing motivational videos versus standard public health text, both offered through gay websites. the methodology the investigators will use is divided in: (1) the development period, where the investigators will select gay websites for banner advertisement, create and refine effective recruitment messages and design the online survey and the video-based intervention (2) the intervention period, where participants who meet the eligibility criteria will be randomized into a video or a standard public health text. the videos will be customized for three audiences based on self-identification: gay, non-gay and trans and will be framed within the health-belief model and the stages of change theory (3) in the outcome evaluation period we will compare the 'intentions to get tested' and 'time to hiv testing at the clinic' among msm of each of the trial arms. if the internet is an effective venue to reach msm for hiv testing, peruvian health programs that target this population may start considering the delivery of web-based interventions and other online prevention services to this under served and hard-to-reach population.


Eligibility criteria:
inclusion criteria: * be 18 years of age or older * be a man and report having had sex with a man * be a resident of lima, peru * answer the survey from lima, peru * have not been tested for hiv during the last year * have an email address that when typed twice matched and * do not report being hiv positive exclusion criteria: * do not meet the inclusion criteria specified above

Keywords: men who have sex with men peru hiv testing video online internet hiv seronegativity
sr-t100 gel efficacy & safety study for vulva pre-cancerous lesions & cutaneous condyloma

Conditions: Vulvar Intraepithelial Neoplasia; Genital Warts

Summary: this pilot clinical study is to evaluate the efficacy \& safety of sr-t100 gel (2.3% of sm in solanum undatum plant extract) in patients with vin(s) or egw(s).

an open-label, pilot study to evaluate the efficacy \& safety profiles of sr-t100 gel in treating patients with vins or egws. male \& female older than 20 years old have at least one vin or egw with lesion size greater than 5 mm in diameter are candidates for this study. the primary endpoint is evaluated based on patients who has received 16-week treatment and presents evaluable measurement datas by the end of 20th week. the secondary endpoints will be evaluated based on all patients with measurable values for vins or egws, recruited patients in this study has never had experiencs associated with prior sr-t100 treatment of any sorts during their life time before becoming a participant in this study. the study plans to recruit 20 patients with vins or egws, the enrollment duration will last two years with total of 40 patients involved.

Eligibility criteria:
(egw group)inclusion criteria: * male \& female patients older than 20 years old presents at least one pathologically confirmed with histopathology egw with lesion size greater than 5mm in diameter. (egw group)exclusion criteria: * patients with invasive neoplasia, enlarged lymph nodes invasive squamous cell carcinoma, having treated with other investigational drugs within 30 days, pregnancy \& lactating females, female with pregnancy potential without using effective boundary barrier or patients with immune-deficience. (vin group)inclusion criteria: * female patients older than 20 years old presents at least one histopathologically confirmed vin with lesion size greater than 5mm in diameter. (vin group)exclusion criteria: * patients with invasive neoplasia, enlarged lymph nodes invasive squamous cell carcinoma, having treated with other investigational drugs within 30 days, pregnancy \& lactating females, female with pregnancy potential without using effective boundary barrier or patients with immune-deficience.

Keywords: condyloma acuminate ano-genital warts genital warts cutaneous condyloma vulva pre-cancerous lesions vulvar intraepitheral neoplasia vin egw
oc000459 bronchial allergen challenge

Conditions: Bronchial Asthma

Summary: oc0000459 reduces inflammation in the tissues in response to allergic stimuli in patients with asthma. this clinical trial, in mildly asthmatic patients, studies the effects of oc000459 and placebo on the asthmatic response to two known stimulants of the asthmatic response in the lungs, namely cat hair, pollen or house dust mite and methacholine.


Eligibility criteria:
inclusion criteria: * known history of asthma (intermittent wheezing, cough, dyspnoea responsive to inhaled short acting beta agonists). * fev1 \>65% of predicted on at least two occasions at screening. * at the screening allergen challenge, a decrease in fev1 of ≥20% in the early asthmatic reaction and of ≥15% in the lar to allergen on 3 separate occasions between 3-10hrs post allergen, 2 of which must be consecutive. * no steroid usage in the past 12 weeks. * testing positive to skin prick challenge with at least one of the following allergens: house dust mite, pollen or cat hair within the previous 12 months. * non smokers for a minimum of 6 months; less than 10 pack year history. exclusion criteria: * respiratory tract pathology other than allergic asthma. * lower respiratory tract infection within 4 weeks prior to an allergen challenge. * receipt of prescribed or otc medication other than paracetamol or short acting inhaled beta agonists within 14 days of screening or of the first day of each dosing period.

Keywords: asthma bronchial allergen challenge sputum eosinophiilia
endocrowns in anterior teeth: effect of cementation protocols and restorative materials on the clinical performance of the restorations

Conditions: Endodontically Treated Teeth; Anterior Teeth

Summary: rehabilitation of anterior endodontically treated teeth with significant coronal damage has been problematic. adopting endocrown design to treat teeth with this condition is still under investigation. to address this issue, the usphs criteria were adopted to assess the anterior endocrown restorations manufactured using various ceramic materials and cemented with different protocols.

40 participants with anterior endodontically treated maxillary central incisors were enrolled to restore their teeth with esthetic restorations patients were divided into two groups, zirconia and e-max groups. each group was, further subdivided into two groups following the cementation protocol. patients were evaluated immediately (baseline) and at. the clinical marginal accuracy measurements were carried out for all groups at baseline, 3, 6, 9, 12, and 18 months and evaluated by 3 investigators using modified (usphs). the patients' satisfaction and potential postoperative discomfort were also assessed and recorded during the same periods. all qualitative data were displayed as frequency (n) and percentages (%). the chi-square test was utilized for qualitative data comparisons. results: as to marginal integrity and patient satisfaction, no significant difference were revealed regarding all scores at different intervals as p\>0.05. conclusions: according to the findings of this study, ceramic endocrowns offer a promising restorative solution for the rehabilitation of anterior endodontically treated teeth. additionally, regardless of the presence of the mdp monomer in its composition, using adhesive resin cement achieved highly successful results when used with mdp-based ceramic primers.

Eligibility criteria:
inclusion criteria: * • freshly extracted teeth. * completely formed apices * minimum root length of 14mm (± 0.5) measured from the cement-enamel junction to the root apex. * straight roots. * teeth with single root canal. * sound teeth with no cracks or fractured parts in its crown or root. * absence of any carious lesions. * no signs of internal or external root resorption. * similar bucco-lingual (bl) and mesio-distal (md) dimensions as determined with a digital caliper. exclusion criteria: * • previously endodontically treated teeth. * markedly curved roots. * root contains more than one canal. * presence of canal calcifications or pulp stones. * internal or external root resorption. * presence of cracks, fractures or caries.

Keywords: digital dentistry, e-max, mdp, zirconia
internal unicompartmental arthroplasty after tibial valgization osteotomy

Conditions: Knee Arthritis

Summary: this retrospective, monocentric study is about outcomes concerning patients who benefit from medial unicompartmental knee arthroplasty after previous high tibial osteotomy. this previous high tibial osteotomy was performed because of genu varum. clinical, funtionnal and radiological outcomes were examined.


Eligibility criteria:
inclusion criteria: * operated between january 2005 and june 2019 * hto followed by implantation of medial uka (oxford partial knee, zimmer biomet, bridgend, uk) in the same knee * medial knee osteoarthritis with healthy lateral compartment * patellofemoral pain * coronal plane deformity of less than 15° exclusion criteria: * death * lost to follow-up * medial uka implant other than the oxford partial knee

Keywords: orthopedic surgery unicompartmental knee arthroplasty high tibial osteotomy
a study to evaluate the effects of a multivitamin/mineral with ginko in subjects with age associated memory impairment

Conditions: Age-Related Memory Disorders

Summary: a study to evaluate the cognitive effects and tolerance of a multi-vitamin/mineral preperation containing gingko in elderly subjects with age associated memory impairment.


Eligibility criteria:
inclusion criteria: * subject is generally healthy (includes subjects presenting with mild chronic diseases where the disease and/or the pharmacological treatment does not result in psychomotor impairment or improvement). * subject is of either gender, and 60+ years of age, inclusive. * subject demonstrates age associated memory impairment after completion of the cdr test battery and comparison to normative data. * female subject who is post-menopausal. * subject is able to understand the study instructions and has given written informed consent prior to study participation. * subject admitted to this study is oriented to person, place and time and has the ability to communicate with the study staff. * subject is, in the opinion of the study staff, motivated to participate and complete the study as instructed. * subject is willing to be attend visits in a well-rested state. exclusion criteria: * subject has participated in an interventional study within the one month prior to screening. * intake within three months prior to screening, or intended intake during the study, of one of the following: ginkgo biloba, st john's wort, ginseng, gotu kola (indian pennywort), or daily doses of vitamin e (-tocopherol) above 30 mg, folic acid above 400 g, vitamins b-1 (thiamine), b-2 (riboflavin), b-6 (pyridoxine) above 2 mg, or other cognition enhancers. * subject has a history of a psychological illness or condition such as to interfere with the subject's ability to understand the requirements of the study. * subject has a history of alzheimers disease, dementia, mental retardation, morbus parkinson, or any other mental disorders. * subject has not been diagnosed with aami after completion of the cdr test battery and comparison to normative data. * subject has a history of any bleeding/coagulation disorder (e.g., haemophilia, protein c or s deficiency). * subject is taking/being treated with a concomitant medication which may affect/inhibit blood coagulation (e.g., warfarin, aspirin, heparin). * subject has history of relevant vascular disorders (e.g., carotid stenosis, stroke, prind, coronary artery disease, peripheral vascular disease, thrombosis). * subject has body mass index (bmi) above 40 kg/m2 (severely obese). * subject smokes more than 15 cigarettes, or equivalent daily. * subject has moderate-to-severe hepatic impairment. * subject has history of alcohol or drug abuse. * subject has known allergies or intolerance to any ingredients in the study preparations. * subject is intending to undergo surgery during or immediately upon completion (within two weeks) of study participation.

Keywords: memory cognitive function elderly gingko age associated memory impairment (aami)
application of overlap method to digestive tract reconstruction of totally laparoscopic left colectomy

Conditions: Colon Neoplasm

Summary: objective:the comparison between total laparoscopic colectomy with intracorporeal anastomosis by overlap method and laparoscopic-assisted colectomy with extracorporeal anastomosis for colon cancer surgery. condition or disease：left colon cancer intervention/treatment： procedure:intracorporeal left colectomy overlap anastomosis procedure: extracorporeal left colectomy convention anastomosis

this a simple randomized, single-center, single-blind, randomized controlled trial study.the patients were randomly divided into experimental groups and control groups by computer.the perioperative recovery data, complications and oncology index of total laparoscopic colectomy with intracorporeal anastomosis and laparoscopic-assisted colectomy with extracorporeal anastomosis would be compared.

Eligibility criteria:
inclusion criteria: * asa\<3 classification * 18kg/m2≤bmi≤30kg/m2 * neoplasm staging is t1-4a, n0-2, m0 * no previous history of abdominal surgery * no previous history of neoplasm chemoradiotherapy * no status of ileus, bowel obstruction and active hemorrhage of the digestive tract exclusion criteria: * age\ 75 years * asa≥3 classification * bmi\ 30kg/m2 * neoplasm staging is t4b or m1 underwent chemoradiotherapy appeared status of ileus,bowel perforation or active hemorrhage of digestive tract patients with pregnant
detection of unsuspected small airways obstruction in cystic fibrosis

Conditions: Cystic Fibrosis in Children

Summary: goal is to physiologically detect unsuspected small airways obstruction in children and adults with treated heterozygous and homozygous cystic fibrosis. unsuspected refers to normal routine pre bronchodilator spirometry including normal fev1(l), fvc (l). and fev1/fvc%. this is a retrospective study.

the current study is based on current investigators previously published patho-physiologic and lung ct studies in small airways intrinsic obstruction, emphysema, and asthma. current investigators have demonstrated that despite the presence of normal routine spirometry including normal fev1(l), fvc (l), and fev1/fvc% that unsuspected small airways obstruction, and emphysema can be detected. this has been achieved by presence of isolated abnormal expiratory airflow limitation at low lung volumes on the maximal expiratory flow volume curves. this includes abnormal expiratory airflow at 75% and 80% expired lung volume. current investigators believe investigators will be able to detect unsuspected small airways intrinsic obstruction, and peripheral airway bronchiectasis proven by lung ct, in patients with cystic fibrosis despite presence of pre bronchodilator normal routine spirometry.

Eligibility criteria:
inclusion criteria: heterozygote or homozygote patients with cystic fibrosis with normal routine pre bronchodilator spirometry including normal fev1(l), fvc(l) and fev1/fvc%. exclusion criteria:heterozygote or homozygote patients with cystic fibrosis with abnormal routine pre bronchodilator spirometry -

Keywords: abnormal fef75 bronchiectasis lung ct
treatment of atrial fibrillation with dual defibrillator in heart failure patients

Conditions: Heart Failure, Congestive

Summary: demonstrate the efficacy of the device-based managed therapy to treat atrial tachycardia and fibrillation (at/af) in patients with chf indication for implant of a crt defibrillator and to demonstrate the advantage of automatic electrical therapy of atrial arrhythmias compared to an in-hospital approach for treatment of symptomatic at/af.


Eligibility criteria:
inclusion criteria: * chronic symptomatic hf despite stable, optimal drug therapy * indication for a cardiac resynchronisation device with defibrillator backup according to current guidelines * patients implanted with cardiac resynchronization device with dual (atrial and ventricular) defibrillation capabilities exclusion criteria: * chronic atrial fibrillation * valvular disease * patients who underwent or are planned for ablation of atrial fibrillation * cerebral vascular accident/transient ischemic attack within 12 months from implant which lead to relevant impairment * preexisting unipolar pacemaker
feasibility of partners in care program for caregivers of patients with acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: this trial studies the feasibility of delivering the partners in care program to caregivers of patients with acute myeloid leukemia. psychological counseling interventions, such as the partners in care program, may help to improve caregivers' psychosocial functioning, marital adjustment in the context of the cancer, communication, and support skills to the patient.

outline: participants are randomized to 1 of 2 groups. group a: participants attend 5 psychoeducational counseling sessions over 30-60 minutes via telephone. group b: participants attend 5 psychoeducational counseling sessions over 30-60 minutes via video teleconference. after completion of study, participants are followed up at 4 months.

Eligibility criteria:
inclusion criteria: * diagnosis of aml within the recent 2 months * caregivers and patients need to write, read, and speak english as one of their languages of choice; and currently sharing a residence at least 50% of the time together * patient must have no other concurrent cancer diagnosis except for basal or squamous cell * caregiver must be able to sustain up to 60 minutes of interaction with patient educator * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * participants will be excluded if either the patient or the caregiver cannot write, read, and speak english as one of their languages of choice; are not currently sharing a residence at least 50% of the time together * the patient cannot have another concurrent cancer diagnosis except for basal or squamous cell * caregiver cannot sustain up to 60 minutes of interaction with the patient educator * caregiver does not have access to a computer with 2-way video capability (i.e. zoom) or a cell phone

Keywords: caregiver
efficacy of macrolide and glucocorticoid in the treatment of chronic rhinosinusitis after endoscopic sinus surgery

Conditions: Chronic Rhinosinusitis; Endoscopic Sinus Surgery

Summary: endoscopic sinus surgery (ess) is widely considered to be the gold standard in the surgical management of chronic rhinosinusitis (crs) that has failed maximal medical therapy. nevertheless, the postoperation medical therapy was considered as a crucial procedure for the success of ess. both glucocorticoids and macrolide antibiotics have been recommended for the treatment of crs, but their effect as postoperation medical therapies of ess need more clinical data to clarify. the purpose of this prospective, randomized,study is to determine the effect of glucocorticoids and macrolide antibiotics for the postoperation medical therapy of ess in different subtypes of crs.

chronic rhinosinusitis (crs) is a multifactorial inflammatory disorder that causes various symptoms including nasal obstruction, rhinorrhea, olfactory dysfunction, facial pain, and headache . endoscopic sinus surgery (ess) is usually recommended for patients who do not response well to conservative treatments. although surgery is effective to alleviate symptoms and improve the quality of life of crs patients, a followed long-term postoperative medical treatment is indispensable. current european and american guidelines recommend glucocorticoids and antibiotics as the primary pharmacotherapeutic approaches for crs before and after ess. however, there are a number of crs patients not responding well to glucocorticoid treatment and conflicting results exist regarding the efficacy of long-term, low-dose macrolide treatment. one potential reason is that crs is a heterogeneous group of disorders unified by similar clinical presentations and its phenotypes and/or endotypes may be important factors determining the efficacy of treatments.

Eligibility criteria:
inclusion criteria: * meeting the crs diagnostic criteria including crssnp and crswnp based on the ep3os definition * age ≥16 and ≤70 years * chinese of either sex * failure to conventional medical therapies according to ep3os recommendation exclusion criteria: * pregnant or breast-feeding women * cystic fibrosis * congenital ciliary dyskinesia * sinonasal fungal disease * systemic vasculitis * granulomatous disease * tumor * immunodeficiency * allergic to clarithromycin or topical corticosteroid * with an upper respiratory tract infection within 4 weeks of entering the study * with serious metabolic, cardiovascular, autoimmune, neurology, blood, digestive, cerebrovascular, respiratory system disease, or any disease interfering with the evaluation of results or affecting subjects' safety such as glaucoma and tuberculosis * with emotional or mental problems * have received immunotherapy within the previous 3 months * have had a history of local or systemic medications, such as glucocorticoids and macrolides within 4 weeks * have had an acute asthmatic within the 4 weeks before entering the study
surveillance modified by artificial intelligence in endoscopy (smartie)

Conditions: Surveillance Endoscopy for Colorectal Cancer; Artificial Intelligence; Polyps of Colon; CADe

Summary: evaluation of an artificial intelligence system for polyp detection (cade)

we aim to evaluate the artificial intelligence system endomind that supports endoscopist in detection of polyps during surveillance endoscopy for colorectal cancer. 1070 patients out of 6 gastroenterologic practice are randomized 1:1 for conventional surveillance colonoscopy vs. surveillance with ai support. primary endpoint is adenoma detection rate.

Eligibility criteria:
inclusion criteria: * indication crc surveillance endoscopy * indication post-polypectomy surveillance endoscopy * positive fecal immunochemical test in patients \>=50 years exclusion criteria: * reasonable suspicion of inflammatory bowl disease * reasonable suspicion of familiar polyposis syndrome * patient after radiation/resection of colonic parts