Kornimate/medical-research-clean huggingface dataset:
the accuracy of choline pet ct in the diagnosis of urological malignancies

Conditions: Urological Malignancies

Summary: pet ct is one of the imaging tools that are used for staging of urological malignancies. c11 choline is a novel isotope with the advantage of its minimal secretion in the urine. this advantage makes it a potentially better metabolic marker then others such as fdg. preliminary studies showed \~95% sensitivity in the diagnosis of tcc. our goal is to continue the evaluation of this method as a diagnostic and follow up tool in different urological malignancies.


Eligibility criteria:
inclusion criteria: * patients older then 18 years of age * full consciousness and awareness * suspected to suffer from urological malignancy and a candidate for a surgical procedur exclusion criteria: * known secondary malignancy
initial study of insomnia/nightmare group treatment for posttraumatic stress disorder (ptsd)

Conditions: Insomnia; Nightmares; Posttraumatic Stress Disorder

Summary: many combat veterans suffer from posttraumatic stress disorder (ptsd), an anxiety disorder that develops after an extremely stressful event or events. ptsd is associated with problems falling asleep or staying asleep. veterans with ptsd also commonly have nightmares from stressful experiences. these symptoms can cause problems in daily life. behavioral treatments that do not involve taking medication have been shown to help improve problems related to sleep and nightmares. however, very few of these treatments address both sleep problems and nightmares at the same time, even though many people suffer from both problems. the purpose of this study is to examine the effectiveness of a combined treatment for sleep problems and nightmares in veterans suffering from combat-related ptsd that is presented in a group format. the investigators hypothesize that the completion of this treatment will lead to increases in sleep quality and decreases in the frequency and severity of nightmares as measured by standard questionnaires.


Eligibility criteria:
inclusion criteria: * must be enrolled in the michael e. debakey vamc trauma recovery program and qualify for a diagnosis of combat-related ptsd related to service in vietnam-era conflicts as measured by responses to the clinician-administered ptsd scale (caps) and total score ≥ 50 on the posttraumatic stress disorder checklist stressor specific version (pcl-s) * have a clinically significant sleep problem as measured by a total score \> 5 on the pittsburgh sleep quality index (psqi) * have a repetitive trauma-related nightmare at least once per week on average, as measured by the nightmare frequency questionnaire (nfq), and which significantly impairs sleep as measured by response ≥ 2 on question 1a of the nightmare effects survey (nes) * be stable on current regimen of psychotropic medication (i.e., no changes to medications and/or dosages) if applicable * must sign consent to be audio-recorded as part of the course of the treatment exclusion criteria: * current substance dependence * planned or ongoing participation in prolonged exposure or cognitive processing therapy during treatment participation * organic psychosis * bipolar i disorder * epilepsy * currently on benzodiazepine or hypnotic medication to treat sleep * currently take prazosin * indication of undiagnosed sleep apnea defined as score ≥ .5 across items 1, 5, and 8 of the multivariable apnea risk index * uncontrolled sleep apnea

Keywords: insomnia group psychotherapy nightmares ptsd posttraumatic stress disorder veterans cognitive-behavioral intervention
video chat during meals to improve nutritional intake in older adults

Conditions: Malnutrition; Loneliness

Summary: the videodining study is a stage ib behavioral intervention development project. the objectives are to determine the feasibility and acceptability of using video chat during mealtimes (videodining) in community-dwelling older adults eating alone at home and to evaluate changes in nutritional intake and loneliness in response to videodining.

the u.s. population is growing older and more adults are aging at home alone, by choice, or due to a lack of affordable senior housing. older adults who live alone have a less healthy eating pattern, eat a smaller variety of foods and consume fewer fruits and vegetables than those living with others. additionally, eating alone, social isolation and loneliness often accompany living alone and are independent risk factors for lower caloric intake, less variety in the diet and malnutrition. community-based interventions are needed to improve the nutritional status of older adults living alone. videodining uses video chat during mealtimes to virtually eat with another person and could provide social interactions and modeling to improve dietary intake in older adults eating alone. extensive observational and experimental research shows that people eat more when dining with others than dining alone, called the social facilitation of eating. additionally, a dining partner's modeling of eating can provide a guide for what and how much to eat. the investigators have conducted a stage ia proof-of-concept study of videodining in older adults and will expand the development of this behavioral intervention with this study. the goals are to determine the feasibility and acceptability of videodining and to evaluate changes in nutritional intake and loneliness in response to multiple videodining sessions in community-dwelling older adults eating alone at home. in this single-arm intervention study, thirty older adult meals on wheels participants will be scheduled to videodine with a dining partner six times. using a mixed-methods approach, the investigators will collect data on older adults' ability to videodine, acceptance of videodining, dietary intake, and loneliness. data will be collected before starting videodining, after each videodining session, and at the end of the study period. development, adaptation and refinement of the videodining intervention are additional key outcomes of this study.

Eligibility criteria:
inclusion criteria: 1. receive meals-on-wheels meals from foodnet in tompkins county, ny. 2. aged 60-95 years old. 3. consume meals-on-wheels meal alone. exclusion criteria: 1. non-english speaking. 2. unable to read and write in english. 3. inadequate vision and hearing to utilize video chat technology. 4. unable cognitively to independently consent and participate in the study. 5. already own and use an amazon echo show.

Keywords: older adults geriatric elderly malnutrition nutrition video chat loneliness social isolation social facilitation of eating aging in place home delivered meals technology
efficacy and safety study of hu00701/hu007 eye drops in patients with dry eye syndrome

Conditions: Dry Eye Syndrome

Summary: a multicenter, placebo controlled, restasis® referenced, randomized, double blind, phase ii study to evaluate the efficacy and safety of hu00701/hu007 eye drops in adult patients with dry eye syndrome


Eligibility criteria:
inclusion criteria: * age over 19 * corneal staining score(oxford grading) \> 2 or schirmer test \ 3mm/5min) * volunteer who went through menopause more than 1 years ago before screening or has surgical menopause * volunteer who has negative result of pregnancy test or use effective contraception exclusion criteria: * current or recent patients used dry eye syndrome medications (topical or systemic) that may affect the status * the patients with systemic or ocular disorders affected the test result * being treated with systemic steroid * wearing contact lenses within 3 days of screening visit * pregnancy or breastfeeding
outcome of transarterial chemo-embolization (tace) in hepatocellular carcinoma patients with partial portal vein thrombosis

Conditions: Hepatocellular Carcinoma (HCC)

Summary: portal vein tumor invasion (pvt) is a common complication in hcc. the studyb aimed to assess the outcomes after tace in patients with branch pvt regarding child classification, radiological response and 1 year survival.

thirty hcc patients (24 male, 6 females) child a cirrhotics with branch pvt. follow up was done at 1, 3, 6 and 12 months after first tace. all patients underwent laboratory investigations including liver function tests to assess deterioration in liver functions, triphasic spiral ct to assess radiological response according to mrecist criteria. survival analysis was performed using kaplan-meier estimations.

Eligibility criteria:
inclusion criteria: * patients with newly diagnosed hcc, * child class a and * portal vein branch tumoral thrombus (proved by imaging) * written informed consent exclusion criteria: * patients with child class b and c, * main portal vein thrombosis, * previous management for hcc, * arterio-portal shunt * refused to be enrolled
efficacy of low-dose percutaneous electrical stimulation in patients with erectile dysfunction.

Conditions: Pudendal Nerve Injury; Erectile Dysfunction; Electric Stimulation

Summary: erectile dysfunction is known as any alteration that produces a modification in the erectile response, whether it is due to organic, psychogenic or relational causes. peripheral percutaneous nerve stimulation is performed using a needle to stimulate the peripheral nerves in such a way as to stimulate most of the area of the structure, stimulating sensory and motor nerve endings in the deeper tissues.

patients will undergo continuous stimulation at a frequency of 20 hertz, a pulse width of 200 µs and for a total of 20 minutes. the intensity will be set at the maximum tolerated by the patient, observing significant changes in erectile function after transanal stimulation at intensities between 20 and 100 ma.

Eligibility criteria:
inclusion criteria: males ages between 18-60 years old primarily organic cause diagnosed by doppler: * peak-systolic velocities (psv). * tele-diastolic velocity (dtv). * resistance index (ri) patients with ≤ 6 months since first assessment. initial iief-ef questionnaire scores: 11-25 points. (mild to moderate erectile dysfunction) active sexual life (more than 4 attempts per month). exclusion criteria: pelvic surgeries history of peyronie's disease penile surgeries, except circumcision or frenuloplasty priapism pelvic radiation female

Keywords: erectile dysfunction percutaneous electrical neurostimulation low dose pudendal nerve
biological outcomes of pramlintide in resectable cutaneous squamous cell carcinoma: a pilot study

Conditions: Cutaneous Squamous Cell Carcinoma

Summary: this study will treat resectable cutaneous squamous cell carcinoma patients with pramlintide for two weeks prior to surgical resection of their tumor. pre-treatment and surgical resection specimens will then be analyzed for biological alterations.


Eligibility criteria:
inclusion criteria: * histologically proven cutaneous squamous cell carcinoma. mixed histologies (basaloid, spindle, sarcomatoid, etc.) are allowed if the pathology review favors squamous cell carcinoma as the majority component. cancers of unknown primary sites are allowed if the clinical history and the site are highly suggestive of a skin cancer primary * tumor site must be amenable for surgical resection and accessible for pre-treatment biopsy * tumor site must be measurable by caliper measurements or by response evaluation criteria in solid tumors (recist)1.1 imaging - lesions must be ≥1 cm * eastern cooperative oncology group (ecog) ≤2 and be medically able to undergo surgical resection * laboratory requirements: hemoglobin ≥ 8 g/dl, platelet count ≥ 50,000/dl, serum creatinine ≤ 1.5 mg/dl or glomular filtration rate (gfr) ≥ 40, serum aspartate aminotransferase (ast) and alanine transaminase (alt) \< 2.5x uln; total bilirubin \< 1.5x uln (for patients with documented history of gilbert's syndrome, total bilirubin level should be \< 3.0 x uln) * ability to understand and willingness to sign a written informed consent document * patients with child bearing potential must be willing to use barrier protection to prevent pregnancy while on study therapy and up to 30 days after the last dose of pramlintide * female subject of childbearing potential should have a negative urine or serum pregnancy within 72 hours prior to receiving the first dose of study medication. if the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required. * patients must be willing to comply with the protocol for the duration of the treatment including daily sub-cutaneous (sq) injections, biopsies, scheduled visits and examinations, radiologic studies, and surgical resection exclusion criteria: * type i diabetes: type ii diabetics (dm2) on insulin are allowed, however, for those dm2 patients that are on short acting insulin, the insulin dose should be reduced 50% and need to have regular glucose monitoring (see section 6.2.1). type ii diabetics not on insulin will not be eligible. * patients with known gastroparesis * patients with known allergic reactions to pramlintide or its ingredients * pregnant women and/or nursing patients will be excluded from this study because of unknown risks to fetus or nursing infants * any serious or uncontrolled medical disorder that could interfere with the current study as deemed by the investigating physician * participation in any other clinical study using an investigational agent within 21 days of starting treatment on this protocol * no prior chemotherapy, radiation, or other tumor directed therapy within 21 days prior of starting treatment on this protocol
e-itag allergen immunotherapy in the management of allergic asthma

Conditions: Study the Efficacy of ITA in Patients With Allergic Asthma or Allergic Rhinitis or Allergic Rhinitis Compared With Conventional Treatment

Summary: allergy is defined as a specific abnormal and excessive reaction of the immune system to exposed allergen . this reaction is reproducible with each new exposure allergen . a recent study by the european academy of allergy and clinical immunology" (eaaci) estimates that 30% of the population suffers from allergic rhinitis and/or conjunctivitis, 20% of children suffer from asthma, and 8% of the population suffers from food allergies in europe, with a clear increase in prevalence. allergenic immunotherapy (ait) remains a corner stone in the treatment of allergic diseases. it involves administering an increasing dose of allergens to induce immunological tolerance. the efficacy and safety of ita have already been demonstrated. however, patient response is highly heterogeneous. this findinf illustrates the value of biomarkers in the selection of patients, enabling prediction of response to ita and follow-up.

this is a prospective, observationel study conducted in pneumology department at the military hospital in collaboration with the immunology laboratory we followed patients in 2 groups: group 1: patients with asthma or allergic rhinitis who had received allergen immunotherapy (ait). group 2: patients with asthma or allergic rhinitis who received a conventional treatment

Eligibility criteria:
inclusion criteria patients with symptoms of asthma or moderate or severe persistent allergic rhinitis allergic rhinitis, with a positive prick test or specific ige assay demonstrating the presence of allergens (1 or 2 allergens). a significant impact on the patient's quality of life rhinitis associated with tracheitis or mild-to-moderate asthma. patients with poorly controlled asthma despite optimal treatment ineffective drug treatment patients willing to adhere to our research protocol exclusion criteria: patients with multi-allergenic asthma (more than 2 allergens) pregnancy (at the time of ita initiation). autoimmune disease immunosuppressive treatment poorly controlled asthma hiv infection cancer severe psychiatric disorders. cardiovascular diseases with a risk of complications during administration of adrenaline. use of beta-blockers. treatment with ace inhibitors. persistent lesions of the oral mucosa (chronic oral aphthosis periodontitis, etc.). worsening of rhinitis. acute febrile state. recent administration of another vaccine (in this case, the ita should not be administered on the same day). ita should not be administered on the same day).

Keywords: ita asthma allergic rhinitis
performance anxiety changes with exercise

Conditions: Performance Anxiety

Summary: this study investigates the effect of high-intense aerobe exercise training (hiit) and aerobe exercise of low intensity on clinical and physiological parameters (anxiety, activity, cortisol, alpha amylase, heart rate, heart rate variability, spiroergometry) in patients with music performance anxiety (mpa). half of the patients will receive hiit, while the other half will receive aerobe exercise of low intensity.

in this study, 20 patients with mpa will receive a high-intensive aerobe training (hiit, 6 hiit-sessions of 20 minutes within a period of 12 days). additionally, 20 mpa-patients will undergo a less intense aerobe training matched regarding frequency and duration of sessions. prior to the first training session, after completing the training (day 12) and 10 days after the training (day 22), symptoms of anxiety and will be assessed by using questionnaires. moreover, heart rate and heart rate variability will be obtained and activity level is measured using accelerometers. before and after the training there will be an assessment of saliva samples for measuring cortisol and alpha amylase. furthermore, a standardized performance situation is established before and after the training. before, during and after the performance anxiety ratings, cortisol, alpha amylase, heart rate and heart rate variability are assessed. the investigators hypothesize, that patients with mpa which undergo hiit, will show a stronger and more sustained improvement of both, clinical symptoms and physiological measures. specifically, a decreased heart rate, higher heart rate variability and decreased endocrinological parameters.

Eligibility criteria:
inclusion criteria: * diagnosis of social anxiety disorder, performance only subtype due to dsm-5 * appropriate abilities to communicate and to complete the questionnaires * written informed consent * possibility of regular attendance at the training sessions * participant is a classical instrumentalist exclusion criteria: * other severe mental conditions than mpa (e.g. schizophrenia, severe depressive episode, addiction) * acute suicidality * epilepsy or other disorders of the central nervous system (e.g. tumor, encephalitis) * contraindications to aerobe exercise training * start or modification of an anxiolytic pharmacotherapy or other therapy within the last four weeks * current psychotherapy * no sufficient capability to consent to trial

Keywords: mpa music performance anxiety hiit exercise cortisol hrv heart rate
myopia control effect of dims spectacle lenses in czech children and young adults

Conditions: Myopia

Summary: the aim of this clinical study is to compare the efficacy of dims technology spectacle lenses with conventional single vision spectacle lenses at slowing the progression of myopia in the category of children and young adults during three years.

the study is non randomized, unmasked, observational and prospective. participants aged 6-26 with progressing myopia (but no ocular pathology), all caucasian, are divided in two groups according to single vision spectacle lenses (sv) and dims technology lenses (dims). the participants are followed during three years (axial length, refraction changes). defocus incorporated multiple segments (dims) spectacle lenses were designed to slow myopia progression in children, based on the principle of peripheral myopic defocus. dims spectacles reduce the progression of myopia and reduce axial elongation by 50-60% compared to single vision (sv) lenses according to previous scientific studies conducted mostly on the asian population under the age of 15. the majority of myopia appears and progresses during childhood. the myopia stabilizes by the age of 18 years, a number of individuals may still present myopic changes. the goals of our study: * compare the efficacy of dims spectacle lenses with sv spectacle lenses at slowing the progression of myopia in the category of czech children and young adults (effect on axial length and refractive changes) * monitoring axial length and refractive changes in myopic children and young adults (aged 6-26) * monitoring adaptation to dims lenses in myopes aged 6-26 years monitoring the influence of the environment and individual behavior on the progression of myopia

Eligibility criteria:
inclusion criteria: * progressive myopia * myopes aged 6-26 years * myopia between -0,25d and -8,5d * astigmatism -0,25 and -2,25dc exclusion criteria: * ocular pathology * amblyopia * strabism * non-compliance to eye examinations

Keywords: myopia axial length dims
dexmedetomidine on postoperative delirium and quality of recovery in geriatric patients

Conditions: Delirium, Postoperative

Summary: postoperative agitation (hyperactive delirium) is common following major surgery(incidence was about 20% in our pilot study). dexmedetomidine was related to a reduced delirium rate when comparing with midazolam in many clinical settings. it is not clear if dexmedetomidine is useful on reducing postoperative delirium. the hypothesis of present study: intraoperative application of dexmedetomidine (0.2ug/kg/h) is is effective (50% reduce) than placebo for reducing of early postoperative delirium and increase postoperative quality of recovery within 24 postoperative hours.

after approval from the institute's ethics committee, this study was conducted at tongji hospital, a general university teaching hospital with 2500 beds in wuhan, china.the study consisted of adult patients, american society of anaesthesiologists physical status (asa-ps) i-iii, undergoing selective major surgery under general anesthesia. all the patients were randomly assigned to receive dexmedetomidine or placebo during the operation. the primary outcome measure was postoperative delirium assessed by nursing delirium screening scale (nu-desc) every 8 hours within 24 postoperative hours. the secondary outcome was length of postanesthesia care unit (pacu) stay,postoperative hospital length of stay, hemodynamic parameters, the incidence of postoperative nausea and vomiting, and quality of recovery determined by quality of recovery (qor40; maximum score 200)and post-operative quality recovery scale (pqrs) in the first 24 h after surgery.

Eligibility criteria:
inclusion criteria: * asa physical status class i-iii * aged 60 years or above * elective major surgery under general anesthesia exclusion criteria: * asa-ps\>=iv * aged under 60 yr old * body mass index (bmi) \>30 * neurologic disease * cardiac surgery and neurologic surgery * anticonvulsant drugs * chronic analgesics intake * participating in the investigation of another study

Keywords: delirium dexmedetomidine adult patients elective major surgery general anesthesia