Kornimate/medical-research-clean huggingface dataset:
effects of a school-based exercise program on posture, trunk range of motion, and musculoskeletal pain

Conditions: Musculoskeletal and Connective Tissue Disorders

Summary: the objective of this study was to evaluate the effects of a school-based exercise program on posture, trunk range of motion and musculoskeletal pain in schoolchildren. this study was a randomized controlled trial. the hypothesis was that the exercise group would have the postural deviations corrected, would have the trunk range of motion increased and would have the prevalence of pain decreased, while the control group would have not. three schools from brazil participated. the students that have been included (n=300) were randomly allocated to experimental (eg) or control group (cg). the intervention for eg consisted in a program based on stretching and strengthening exercises, applied twice a week, for eight weeks, with group sessions of 50 minutes. cg did not perform any intervention. qualitative and quantitative postural evaluation (pas/sapo), musculoskeletal pain (self-report) and trunk mobility were collected.


Eligibility criteria:
inclusion criteria: to attend elementary school and deliver the consent term signed by the parents. - exclusion criteria: presence of disability on musculoskeletal or neurological system, exercise intolerance or attendance less than 50% in the exercise sections -

Keywords: posture child prevention muscle strength muscle stretching exercises exercise therapy disease management musculoskeletal pain adolescent spinal curvatures
study evaluating dvs-233 for treatment of outpatients with major depressive disorder

Conditions: Major Depressive Disorder

Summary: to evaluate the long-term safety of desvenlafaxine sustained release (dvs-233sr) during open-label treatment of outpatients with major depressive disorder (mdd).


Eligibility criteria:
inclusion criteria: * outpatients. * men and women aged 18 to 75 years. * women of childbearing potential must have a negative serum pregnancy test result at screening. sexually active individuals participating in this study must use a medically acceptable form of contraception during the study and for at least 15 days after the last dose of test article. * subjects must have a primary diagnosis of mdd based on the criteria in the diagnostic and statistical manual of mental disorders, 4th edition (dsm-iv), single or recurrent episode, without psychotic features, on study day 1. if other allowable psychiatric diagnoses are present, mdd must be the predominant psychiatric disorder present. (see exclusion criterion 6 for psychiatric diagnoses that are not allowable.) * depressive symptoms for at least 30 days before the screening visit. * subjects who have symptoms of depression judged by the investigator to require long-term treatment (i.e., 6 months or longer) with an antidepressant drug. other inclusion applies. exclusion criteria: * treatment with dvs-233 sr at any time in the past. * treatment with venlafaxine (immediate release \[ir\] or extended release \[er\]) within 90 days of study day 1. * known hypersensitivity to venlafaxine (ir or er). * significant risk of suicide based on clinical judgment, including common suicidal thoughts, and suicide being considered as a possible solution, even without specific plans or intention. * women who are pregnant, breastfeeding, or planning to become pregnant during the study. * current (within 12 months of baseline) psychoactive substance abuse or dependence (including alcohol), manic episode, posttraumatic stress disorder, obsessive-compulsive disorder, or a lifetime diagnosis of bipolar or psychotic disorder as assessed by the modified mini international neuropsychiatric interview (mini). current (within 12 months of baseline) generalized anxiety disorder, panic disorder, or social anxiety disorder as assessed by the modified mini and considered by the investigator to be primary, causing a higher degree of distress or impairment than mdd. presence (within 12 months of baseline) of a clinically important personality disorder (such as antisocial, schizotypal, histrionic, borderline, narcissistic). * depression associated with the presence of an organic mental disorder due to a general medical condition or a neurologic disorder. * history of a seizure disorder other than a single childhood febrile seizure. other exclusion applies.
whey protein-based enteral nutrition support to improve protein economy in surgical patients

Conditions: Protein Metabolism; Colorectal Neoplasms

Summary: a prospective, randomized and controlled study is proposed to establish whether an enteral nutrition support regimen based on pressurized whey protein and glucose improves the postoperative utilization of amino acid substrates compared to a drink based on glucose alone. the kinetics of protein metabolism (protein breakdown, protein synthesis and amino acid oxidation) will be investigated using stable isotope methodology before and after surgery in patients undergoing colon resection. stable isotope infusions will be conducted one week before surgery and on the second postoperative day for two hours in the fasted state and for four hours while sipping the enteral nutrition support regimen. patients will consume one of two enteral nutrition support regimens consisting of a drink containing either pressurized whey protein and glucose or glucose alone. it is hypothesized that an enteral nutrition support regimen based on pressurized whey protein and glucose promotes positive protein balance through increased protein synthesis or reduced protein breakdown compared to glucose alone.


Eligibility criteria:
inclusion criteria: * age older than 18 years * asa class i to iii * colorectal surgery for non-metastatic disease (including right, transverse, left, sigmoid, subtotal, total and hemicolectomy and low anterior resection) * body mass index \>17 and \<30 kg.m-2 * stable weight over the preceding three months (\<10 % body weight loss) * serum albumin \>35 g/l exclusion criteria: * severe cardiac, renal or hepatic failure * diabetes * hyper and hypothyroidism * active inflammatory bowel or diverticular disease * musculoskeletal or neuromuscular disease * anemia (hematocrit \<30) * albumin \< 25 g/l * pregnancy * use of steroids.
balloon catheter vs. basket catheter for endoscopic bile duct stone extraction

Conditions: Biliary Calculi

Summary: endoscopic bile duct stone (bds) removal is a well-established treatment; however, the preference for basket or balloon catheters for extraction is operator-dependent it is reported that complete endoscopic treatment with a single catheter is more likely when choosing a balloon catheter over a basket catheter for extraction of bdss≤10mm. however, a study comparing the two catheter types in patients with periampullary diverticulum has not been performed, and there is no strong basis on which to recommend the balloon catheter as a first-line stone removal device. the investigators therefore conducted a multicenter prospective randomized trial to compare catheter performance in patients with periampullary diverticulum.

a prospective, multi-center, investigator sponsored, randomized controlled trial, 80 subjects will be randomly assigned to groups that were treated with basket or balloon catheters. a descriptive analysis will be performed on primary endpoint, containing frequency of number and percentage of patients. a two proportion equality test will be conducted to explore whether incidence rates are different.descriptive statistics including number (n), mean, median, standard deviation, minimum and maximum, will be produced for all continuous variables. frequency tables of number (n) and percentage of subjects will be produced for all categorical variables.

Eligibility criteria:
inclusion criteria: 1. males and females, age \> 18 years. 2. bdss of diameter ≤10mm, which could be extracted using a standard balloon or basket catheter without mechanical lithotripsy, and a common bile duct (cbd) diameter ≤15mm. 3. signed inform consent form and agreed to follow-up on time exclusion criteria: 1. medical or psychological condition that would not permit the patient to complete the study or sign the informed consent. 2. patients involved in other study within 60 days. 3. biliary stricture 4. billroth ii or roux-en-y anatomy 5. acute pancreatitis. 6. a history of previous ercp 7. pregnant or breastfeeding women
identification of predictive factors for failure of cholangioscopy-assisted lithotripsy in the management of complex bile duct stones: a retrospective study

Conditions: Bile Duct Stones

Summary: this study aims to optimize the management of complex biliary stones by identifying predictive factors for spyglass lithotripsy failure.


Eligibility criteria:
inclusion criteria: * any adult patient who underwent cholangioscopy-guided lithotripsy for bile duct stones between january 1, 2018, and may 30, 2025 exclusion criteria: * patient who objected to the collection of their data

Keywords: cholangioscopy spyglass failure complex bile duct stone predictive factor electrohydraulic lithotripsy ehl lithotripsy ercp
high and low intensity speech intervention in children with a cleft palate: perceptions of children, their caregivers and speech-language pathologists

Conditions: Cleft Lip and Palate; Speech Disorders in Children

Summary: a cleft (lip and) palate (cp±l) is the most common congenital abnormality of the face and skull with a significant social impact, affecting speech, hearing, feeding, oral behavior, dentition and satisfaction with appearance. these consequences have a long-term and negative impact on social integration and well-being. the world health organization (who) highlights the significant financial costs, including morbidity, health care costs, emotional distress and social exclusion for patients, their families and society. the purpose of this study is to compare high- and low-intensity speech intervention in children with cp±l based on the perceptions of the providers of the intervention (primary care speech-language pathologists) and the recipients of the intervention (children with cp±l and their caregivers). individual semi-structured interviews will be conducted with both intervention providers and recipients to explore perceptions and experiences, as well as acceptability of the two speech intervention intensities. potential participants will be told that the interview will be recorded. the actual interviews will take place at a location and time that is most convenient for the participants. each interview will be recorded using a roland r-05 high-quality audio recorder. after conducting the interviews, all participants will be asked to complete a questionnaire regarding their demographics. in addition, data regarding the type of cleft, time and manner of closure of the cleft, any secondary surgery and otological/audiological data will be collected from the medical records of the children with cp±l. based on this qualitative study, possible adjustments to the high-intensity therapy protocol can be made. in doing so, these modifications will be relevant to these key stakeholders. this will also facilitate the implementation and widespread use of high-intensity speech therapy in clinical speech therapy practice.


Eligibility criteria:
inclusion criteria: * belgian dutch-speaking children with a cleft palate with or without a cleft lip * aged between 4 and 12 years, * presence of at least one compensatory speech error in their speech based on the perceptual assessment of one experienced speech-language pathologist exclusion criteria: * children with syndromic clefts * oronasal fistula * velopharyngeal insufficiency * hearing disabilities based on pure tone audiometry (\>25 db hl) * cognitive and/or related learning disabilities or neuromuscular disorders

Keywords: cleft lip and palate qualitative research speech therapy interviews speech intervention intensity
symptom clusters in hong kong chinese children with blood cancer

Conditions: Child

Summary: pediatric blood cancer is the most common childhood malignancy. despite its survival has been substantially improved, children still have to pay a high price for numerous distressing symptoms resulted from chemotherapy. previous studies related to symptom experiences mainly focus on individual symptoms, rather than on multiple symptoms. understanding these distressing symptoms may help healthcare professionals to develop appropriate and effective interventions with the aims of alleviating symptom severity and thus promoting the child's psychosocial well-being and quality of life.

a longitudinal study design will be conducted. a sample of 120 patients age 5-17years, diagnosed with blood cancer but not yet receive any chemotherapy and able to communicate with cantonese and read chinese will be recruited in the pediatric oncology ward of hong kong children's hospital.

Eligibility criteria:
inclusion criteria: * aged 5 - 17 years old * diagnosed with blood cancer but not yet receive any chemotherapy * able to communicate with cantonese and read chinese exclusion criteria: * who are scheduled to have concurrent cancer treatment * with recurrent malignancy * medical condition, or cognitive and learning problems in their medical records

Keywords: blood cancer chemotherapy
perineural low-dose dexamethasone added to infraclavicular block anesthesia

Conditions: Postoperative Pain

Summary: dexamethasone has an evidence-based indication in postoperative emesis prophylaxy and as a antiinflammatory steroid. although the perineural administration is off-label, several studies recognised its analgetic action as an adjuvant for peripheral nerves blockade, permitting to reduce the concentration of the local anesthetics and extending the sensory and motor block.questions remain concerning the mechanism of action, optimal dose, the lack/degree of toxicity and the comparison with intravenous administration.the aim of this prospective randomized controlled study is to investigate the efficacy of analgesia with 4 mg or 2 mg dexamethasone added to a combination of ropivacaine 0,5% and lidocaine 1% in vertical infraclavicular blockade (vib) anesthesia for upper limb surgery.

the investigators conducted a prospective randomized controlled study in 150 patients american society of anesthesiologists (asa) score i-iii scheduled for upper limb surgery , divided in 3 groups: group a received anesthesia vib block with ropivacaine 0,5% 100 mg +lidocaine 1%+1 ml saline; group b received vib block with ropivacaine 0,5% 100 mg +lidocaine 1% + 2 mg dexamethasone; group c received ropivacaine 0,5% 100 mg +lidocaine 1% + 4 mg dexamethasone.the anesthesiologist may use the ultrasound for visual guidance, but should also use the nerve stimulator in order to maintain the homogeneity of the procedure. intraoperative sedation was provided with intermittent bolus 10-20 mg iv propofol. postoperatively all patients received the same analgetic protocol when visual analog pain scale (vas) over 3 with iv perfalgan and lornoxicam 8 mg/12 hours for 24 hours. if after 30 minutes vas is still over 3, a loading dose of morphine 0,05 mg/kg should be administered. at first analgetic request, the nurse conducts an ice-probe test to both arms and will note the answer: same cold, slightly burn, burn, aching with the reason to test the potentially hyperalgesia effect related to ropivacaine. the data recorded are: time to first analgetic use, vas at block regression, ice-probe test, motor and sensitive block duration, glycemic variations at 4 h, neurological complications immediately after block, total morphine consumption.

Eligibility criteria:
inclusion criteria: * asa i-iii, * bmi\<40, * non-anemic exclusion criteria: * high risk grade hypertension, chronic renal failure, known allergy to local anesthetic or nsaids, chronic treatment with steroids, drugs dependency, history of diabetes mellitus, ulcer or chronic gastritis, infection on the puncture site, chronic obstructive pulmonary disease, neuropathy at the surgical level
neurodynamic intervention in fibromyalgia

Conditions: Fibromyalgia

Summary: fibromyalgia is a chronic illness characterised by persistent,widespread muscle pain with generalised hyperalgesia and allodynia. it can be accompanied by other concomitant symptoms like fatigue, sleep disturbances, musculoskeletal disorders, distress and psychological disorders. this condition is very prevalent. it has been reported to be about 2-5% of the general global population. fibromyalgia have been reported to have neurodynamic disorders. the purpose of this prospective study was to examine the combined effects of soft tissue mobilization and nerve slider neurodynamic technique on pain and pressure sensitivity in women with fibromyalgia.

fibromyalgia affects women nine times more than men.the pathophysiology of fibromyalgia is being studied nowadays in order to understand the mechanisms implicated in it. the treatment propose in this study is a neurodynamic intervention. neurodynamics is the term used to describe the integration of the morphology, biomechanics and physiology of the nervous system.

Eligibility criteria:
inclusion criteria: * women diagnosed with fibromyalgia attending to the fibromyalgia association of granada. * women who can complete the assessment battery of tests at the beginning and at the end of the study * female sex. exclusion criteria: * male sex. * auditive and visual disturbances. * cognitive problems. * psychiatric pathology. * traumatic pathology of the hand.

Keywords: fibromyalgia, neurodynamic, dexterity
treatment of chronic leg ulcer in outpatient's department and i primary care - wound size and inflammation

Conditions: Treatment of Leg Ulcer; Sharp Debridement; Proinflammatory Cytokines

Summary: the purpose of this study is to investigate the rate of wound healing using sharp debridement using curette and to compare between such intensive treatment at hospital and treatment in primary care. a correlation between change in wound size and pro-inflammatory cytokines will also be made.

subjects with chronic venous leg ulcers are treated 3 times a week in the hospital for 6 weeks with weekly sharp debridement. wound size, pro-inflammatory cytokines, smears and photo are made weekly. the treatment countinue thereafter in primary care 3 times a week in 12 weeks. wound size, pro-inflammatory cytokines, smears and photo are made every 14 day at the hospital.

Eligibility criteria:
inclusion criteria: * ulcus cruris venosoum * aai \> 0.9 * age 18-80 * adress oslo area * wound size 2.5-100 cm2 * wound duration \> 6 weeks. exclusion criteria: * diabetes mellitus * immunosuppresion * antibiotics \< 14 days * local antiseptic treatment \< 1 week * clinical infection.

Keywords: leg ulcer wound therapy pro-inflammatory interleukins
patient recall of cancer screening and diagnosis

Conditions: Breast Cancer; Prostate Cancer

Summary: the purpose of this research is to try to better understand how much information relating to cancer screening and diagnoses that people can recall on their own and to better understand how to help people get better information. in this study, investigators will see if giving time or other resources help individuals remember more and more accurate details about their cancer screening and care.

this is a randomized controlled trial of an intervention to encourage use of online medical records for filling out a cancer screening, diagnosis and treatment questionnaire. participants will be asked to self-report on cancer screening and treatment. they will then be asked the same questions again a week later. the control group will have had one week to reflect on the questions, and investigators anticipate some influence of this on responses. the intervention group will be prompted about accessing their medical records from the major local health systems online, with links to directions provided by each hospital system. they will then be asked to fill out the same questionnaire.

Eligibility criteria:
inclusion criteria: * diagnosed with breast or prostate cancer within the last 10 years * have access to the internet with a working email address * reside in northeast ohio exclusion criteria: -
the effect of remifentanil infusion during emergence on the incidence of emergence delirium

Conditions: Delirium

Summary: the aim of the present study is to assess the effect of postoperative remifentanil infusion on the incidence of emergence agitation in preschool-aged children undergoing strabismus surgery with sevoflurane anaesthesia.

patients are randomly assigned to one of two groups. anesthesia is maintained with sevoflurane and remifentanil infusion. all patients received a predetermined concentrations of remifentanil according to their group assignments (control group, remifentanil 0 ug/kg/min; remifentanil group, remifentanil 0.05 ug/kg/min) from 10 minutes before the end of surgery to discharge from postanesthetic care unit. emergence agitation is assessed during the emergence phase.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists physical status i and ii * preschool-aged children undergoing strabismus surgery exclusion criteria: * psychological disorders * emotional disorders * abnormal cognitive development * developmental delay * allergy to the drugs in our protocol