Kornimate/medical-research-clean huggingface dataset:
effects of balanced and sustainable diet application for insulin resistance and inflammation marker of obese people

Conditions: Obesity; Insulin Resistance; Inflammation; Blood Glucose, High

Summary: this study evaluates the effect of balanced and sustainable diet application on fat composition, insulin resistance and inflammation marker in obese people. intervention: obese subject will receive intervention on balanced and sustainable diet application control: obese subject will receive a balanced diet application only

maintaining the adherence of weight loss programme while selecting healthy and sustainable foods will become a worldwide future challenge in nutrition. therefore, we investigated the suitable content, graphic, and flow in developing a mobile application as an alternative solution for enhancing the compliance of weight control and selecting healthy food with the least environmental impact. the treatment for obesity consists of dieting, physical exercise, pharmacology, and surgery. restricted balanced diet is a well known diet recommendation for people with obesity. sustainable diet is an alternative form of diet which contributes to healthy life and is protective of biodiversity. the main challenge in obesity management is the sustainability of weight loss programme. mobile apps are an alternative solution for enhancing compliance.

Eligibility criteria:
inclusion criteria: * body mass index ≥ 25 kg/m2 * using android-based smartphone * willing to join this research by signing informed consent exclusion criteria: * pale in physical examination * in weight loss program * have obesity with comorbidities * have hormonal diseases * consumed hormonal drug, ptu, anti diabetes drug * smoking or stop smoking under 2 years * pregnant and breastfeeding women

Keywords: obesity
exercise with or without electrical stimulation in cystic fibrosis (part i): effects on physical fitness

Conditions: Cystic Fibrosis in Children

Summary: this study aims to assess the effects of programmed exercise with or without electrical stimulation in the cardiorespiratory fitness, strength, functional capacity and agility in a group of young patients with cystic fibrosis: a randomized controlled trial comparing two interventions with a control group.


Eligibility criteria:
inclusion criteria: * diagnosis of cf * age: 6-18 years old * signature of informed consent of legal guardian and patient. exclusion criteria: * being a smoker * having had an exacerbation in the last 3 months * having undergone gastric surgery * having enteral nutrition at present * the patients will come from the hiunj of madrid. * currently taking cftr modulators

Keywords: cystic fibrosis electrostimulation combined training physical fitness
congenital lung anomalies (cla) swiss database

Conditions: Congenital Lung Malformation; Congenital Lung Cyst; Sequestrum; Bronchogenic Cancer; Pleuropulmonary Blastoma; Acinar Dysplasia

Summary: congenital lung anomalies include different pathologies such as congenital cystic adenomatoid malformation, pulmonary sequestration, bronchial atresia, emphysema, bronchogenic cyst. they concern less than 1/10000 births and their physiopathological origin is still poorly understood. the main goal of this project is to pool the cases from different swiss centers on a prospective cohort study, first to increase knowledge of clinical and radiological evolution and their correlation with histological data, and second to analyse the pathological embryological mechanism underlying these malformations.

1. to register prospectively clinical, biological, radiological and histological datas in a multicentric database (secured internet link, via secutrial® software). for children with prenatal diagnosis of this kind of malformation. this study is conducted by a multidisciplinary team, involving obstetricians, neonatologists, pneumologists, pediatric surgeons, radiologists and anatomopathologists. 2. to create a tissue biobank outcomes: 1. contribute to the definition of a standardized procedure at the swiss level for the treatment of patients suffering from these malformations, 2. improve the assessment of lesion evolution related to cla, and 3. possibly validate some biomarkers, which could help to identify individuals at risk. on the long term, these results could also support the development of innovative therapies targeting the factors involved in lung development.

Eligibility criteria:
inclusion criteria: * all patients diagnosed with congenital lung anomalies exclusion criteria: * none

Keywords: congenital lung anomalies
implementing a postoperative mirp (minimally invasive repair of pectus) program via tele-monitoring

Conditions: Postoperative Pain; Postoperative Nausea

Summary: mirp (minimally invasive repair of pectus) as surgical correction of pectus excavatum or carinatum is performed to achieve physiological, cosmetic, and psychological benefits for the patient. surgery is often associated with severe postoperative pain. in this study the researchers want to registrate pain, sleep, nausea/vomiting, and daily activities in short and long term follow up.

in order to provide pain patients with an individualized approach to their pain problem after mirp we developed an electronic medical record coupled to a set of telemetric medical-grade devices. appi@home (antwerp personalized pain initiative) supports an innovative approach to (sub)acute conditions by offering a platform for continuous follow-up. patients are provided with a toolbox and an app that continuously collects objective outcome data (i.e. pain intensity, sleep quality, physical activity). the integrated system allows the care givers to respond very quickly to changing clinical conditions of the patient, making a very adaptive and individualized follow-up possible for these patients. in addition, the patient becomes an active participant in the global therapeutic approach. patients receive the toolbox two week prior to surgery with access to the internet platform for questionnaires fill-in procedure. up to ten week after surgery pain intensity, sleep quality and physical activity will be monitored subjectively by a scoring table (0-10, 0 no pain-bad sleeping quality-no activity, 10 maximum of pain-excellent sleeping quality- a lot of activity) and objectively by blood pressure device, oxygen saturation monitoring, activity tracker and sleep registration tool.

Eligibility criteria:
inclusion criteria: * elective pectus repair * signed informed consent exclusion criteria: * chronic opioid use (\> 3 months) * history of ongoing psychiatric disease
face-to-face vs. telerehabilitation for thoracic hyperkyphosis in children: a clinical trial

Conditions: Kyphosis Thoracic; Hyperkyphosis

Summary: this study evaluates the effectiveness of face-to-face versus telerehabilitation programs for children aged 9-12 with thoracic hyperkyphosis, a condition caused by poor posture that leads to excessive forward curvature of the spine. twenty children participated in a six-week corrective exercise program, either in person or through an online platform. both approaches significantly improved spinal posture, back muscle strength, and pain levels, with no notable differences in outcomes between the two methods. the findings suggest that telerehabilitation is as effective as face-to-face rehabilitation, offering a flexible option for managing thoracic hyperkyphosis in children.


Eligibility criteria:
inclusion criteria: * children aged 9-12 years. * diagnosed with thoracic hyperkyphosis (thoracic kyphosis angle \> 40 degrees). * able to participate in a 6-week rehabilitation program (face-to-face or telerehabilitation). exclusion criteria: * children with congenital spinal malformations. * children with mental health issues that could interfere with participation or compliance in the study.

Keywords: thoracic hyperkyphosis face-to-face rehabilitation telerehabilitation spinal posture musculoskeletal health corrective exercises pediatric kyphosis
phase iii clinical trial of a candidate pcv13 in healthy people aged 6 weeks and above (pictpcv13i)

Conditions: Pneumococcal Infections; Streptococcal Infections; Bacterial Infections

Summary: streptococcus pneumoniae is a major cause of morbidity and mortality in children worldwide, resulting in up to 1 million pediatric deaths every year.since the licensure of pcv7 and pcv13,the reported overall decline in invasive pneumococcal disease in hospitalized children younger than 5 years several years is approximately 60% in western countries.this is a single center,blind, randomized, positive-controlled clinical trial.the purpose of this study is to preliminary evaluate the safety of pcv13i vaccine in subjects at age of 7 months and above,and to investigate the safety and immunogenicity of pcv13i vaccine at age of 2 and 3 months,compared to pcv13.


Eligibility criteria:
inclusion criteria: * healthy subjects of 2 months (minimum 6 weeks), 3 months , 7 months and above; * willing to provide proof of identity; * without vaccination history of pneumococcal vaccine; * none-pregnancy or do not plan to pregnancy recently;; * volunteers of 18 years old and above who have the ability to understand clinical studie progress and sign informed consent; * volunteers of 8-17 years old and their guardians who willing sign informed consent; * able to understand and sign the informed consent by their guardians or trustees for the volunteers of 8 years old and below; * able and willing comply with the requirements of the protocol exclusion criteria: * volunteers whose axillary body temperature was \>37.0# before vaccination * volunteers who suffered from congenital malformation or developmental disorder, genetic defect, severe malnutrition, etc; * volunteers who has a history of epilepsy, convulsions or psychosis; * allergic person; * any prior administration of blood products in last 3 month; * any prior administration of other research medicines in last 1 month; * plans to participate in or is participating in any other drug clinical study; * any prior administration of attenuated live vaccine in last 14 days; * any prior administration of subunit or inactivated vaccines in last 7 days; * had fever before vaccination, volunteers with temperature \>37.0°c on axillary setting; * according to the investigator's judgement, the subjects have any other factors that make them unfit to enroll the clinical trial

Keywords: pcv13 13 valent pneumococcal conjugate vaccine pneumococcal infections safety immunogenicity
the efficacy of color-doppler ultrasonography to assess the renal blood flow with the estimation of gfr

Conditions: Hypertension; Renal Failure

Summary: it is generally assumed that renal blood flow is symmetric in the absence of renal artery stenosis. the importance of studying the function of both kidneys separately is because it cannot be assumed that they are functionally equal.the aim of the present study is to evaluate whether this is really in patients with essential hypertension and/or moderate kidneys loss.

to validate color doppler ultrasonography of renal arteries for the assessment of renal blood flow (rbf), we comparing left and right rbf estimates and their sum (total rbf) by echo-doppler with data obtained by 99mtc-dtpa scintigraphy in 50 patients with hypertension and/or moderate renal failure, compared with 30 normal control subjects.

Eligibility criteria:
inclusion criteria: * patients with hypertension * patients with moderate renal insufficiency * normal subjects exclusion criteria: * patients with solitary kidney function * patients with renal artery stenosis * patients underwent renal angioplasty and stenting

Keywords: color-doppler ultrasonography renal scintigraphy kidney failure gfr
orally administered trimethoprim-sulfamethoxazole and metronidazole as prophylaxis of infection following elective colorectal surgery

Conditions: Infection Prophylaxis in Colo Rectal Surgery

Summary: the current standard swedish infection prophylaxis in colorectal surgery is intravenously administered cefuroxime and metronidazole. this combination is well studied. the disadvantages of the regimen is "collateral damage" resulting from treatment with a cephalosporine and that the combination also serves as the first line of treatment for abdominal surgical infections. serval swedish surgical departments have for some years used a combination of orally administered trimethoprim-sulfamethoxazole and metronidazole. the combination is economical and believed to be effective but hitherto the outcome have not been properly researched. the aim of this study is to compare the efficacy of these two regimens in the prevention of infection after elective colorectal surgery.


Eligibility criteria:
inclusion criteria: * age \>= 18 years * planned clean/clean-contaminated colorectal resection will be performed * understand spoken and written swedish language exclusion criteria: * hypersensibility to the test or control drug * severe liver failure * blood dyscrasia * ileus or gastric retention * current visceral perforation * current treatment with antibiotics * current treatment with steroids * cytotoxic or radiation therapy within 4 weeks of the planned operation * active ibd (inflammatory bowel disease) * incapability to swallow tablets * other study interfering with this study * current pregnancy * bad regulated diabetes * current enterocutaneous or colocutaneous fistula

Keywords: surgical site infections
acute and chronic metabolic flexibility in individuals living with obesity: the i-flex study

Conditions: Obesity; Obesity; Endocrine; Insulin Sensitivity; Exercise

Summary: regular exercise is a cornerstone in the prevention and the management of cardio-metabolic risk factors. some of the beneficial effect of exercise training occurs through metabolic flexibility' enhancement. metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand, and previous literature has shown that individuals living with obesity have an impaired metabolic flexibility compared to lean individuals. however, there is a lack of empirical evidence on the impact of sprint interval training on metabolic flexibility and whether this translates into clinically meaningful outcomes. this study will evaluate the impact of 4-week sprint interval training in normal weight individuals as well as individuals living with obesity on acute and chronic metabolic flexibility, irisin secretion and insulin sensitivity.


Eligibility criteria:
inclusion criteria: * adults (ages 19-60) * physically inactive for individuals living with obesity (not meeting canadian physical activity guidelines) * normal weight (bmi ≥ 18.5 \< 25.0 km/m2) * obesity (bmi ≥ 30.0 km/m2) exclusion criteria: * individuals with type 2 diabetes. * individuals with impaired glucose tolerance. * individuals living with obesity that partake in regular exercise training / meet the canadian physical activity guidelines. * individuals with a condition or injury that may impact the ability to perform exercise or may be worsened by exercise. * individuals currently being treated with corticosteroids or atypical antipsychotics, as these agents significantly influence carbohydrate metabolism. * have experienced \>10% weight loss or enrolled in weight loss program within six months of enrolment. * require use of medication(s) known to affect insulin sensitivity or secretion within the last 30 days. * medication(s) known to cause weight gain. * weight loss medication(s).

Keywords: metabolic flexibility insulin sensitivity sprint interval training obesity exercise intensity
an open-label extension study of canakinumab in patients with systemic juvenile idiopathic arthritis and active systemic manifestations manifestations and response characterization study in canakinumab treatment-naïve patients with active sjia with and without fever.

Conditions: Systemic Juvenile Idiopathic Arthritis

Summary: this open-label extension study will permit patients with systemic juvenile idiopathic arthritis (sjia) who previously were responsive to treatment with canakinumab and canakinumab treatment-naïve patients with active sjia with and without fever to be retreated with 4 mg/kg s.c. every 4 weeks and assessed for continued efficacy and safety until discontinuation or when study cacz885g2402 is in place at their study center or around march 2013, whichever occurs first. patients who are steroid-free will be able to taper their canakinumab dose to 2 mg/kg s.c. every 4 weeks.


Eligibility criteria:
inclusion criteria: * patients from study cacz885g2305 or cacz885g2301 who achieved an adapted acr pediatric 30 response 15 days after their initial dose of canakinumab but clinically deteriorated afterwards or a minimum acr pediatric 30 response was not maintained after day 15 and intervention is deemed necessary by the investigator, or patients in study cacz885g2301 who are not eligible to enter part ii (withdrawal part) because they were not able to meet the corticosteroid entry criteria , or responder patients in part i or part ii who had not flared when cacz885g2301 was stopped, or cacz885g2301 patients who were responders in part i but experienced a flare in part ii. * treatment-naïve patients need to meet the following criteria: * confirmed diagnosis of systemic juvenile idiopathic arthritis as per ilar definition that must have occurred at least 2 months prior to enrollment with onset of disease \< 16 years of age * male and female patients aged ≥ 2 to \< 20 years of age * active disease at the time of enrollment defined as having 2 or more of the following: * documented spiking, intermittent fever (body temperature \> 38°c) for at least 1 day during the screening period and within 1 week before first canakinumab dose * at least 2 joints with active arthritis * and c-reactive protein (crp) \> 30 mg/l (normal range \< 10 mg/l) rash serositis lymphadenopathy hepatosplenomegaly * naïve to canakinumab other protocol-defined inclusion criteria may apply exclusion criteria: * history of allergy or hypersensitivity to study drug * with active or recurrent bacterial, fungal or viral infections at time of enrollment other protocol inclusion/exclusion criteria may apply

Keywords: flare arthritis il-1beta antagonist systemic juvenile idiopathic arthritis chaq steroids acr pediatric response systemic juvenile idiopathic arthritis with active flare
short implants in atrophic posterior maxilla

Conditions: Edentulism; Bone Atrophy, Alveolar; Sinus Pneumatization

Summary: this study aims to evaluate the clinical and radiological outcomes of short implants in the rehabilitation of single-tooth edentulism in the posterior maxilla. by assessing these outcomes, the research seeks to determine the effectiveness and long-term viability of short implants as a minimally invasive solution, particularly in cases where bone height is limited.

the present municentric retrospective study was conducted following the strobe statement recommendations for observational studies and in compliance to the principles of the declaration of helsinki on clinical research involving human subjects.the study aims to evaluate short implants placed over the past 15 years by three experienced clinicians, assessing their survival and clinical success. specifically, the study collects clinical data such as probing depth, the presence or absence of peri-implantitis, and radiological findings.

Eligibility criteria:
inclusion criteria: * good health status according to the classification system of the american society of anesthesiology (asa), and patients were required to be 18 years of age or older. * no general medical condition that would contraindicate implant therapy. * no active periodontal disease, defined as a periodontal probing depth of less than 4 mm, or previously treated periodontitis. * good oral hygiene, with a full-mouth plaque index of less than 25%. * adequate control of inflammation, with a full-mouth bleeding on probing (bop) of less than 25%. exclusion criteria: * smoking more than 15 cigarettes per day * presence of untreated periodontal disease * pregnancy or breastfeeding at the time of enrollment * active infections * less than 2 mm of keratinized mucosal tissue.

Keywords: short implants bone atrophy sinus pneumatization minimal invasive
children with adhd symptoms: comorbid conditions, cognitive and social performance

Conditions: Comorbid Conditions; Social-demographic Profiles

Summary: this article reviews social-demographic variables (sdv) including interpersonal and academic and social performance in families and comorbid conditions(cc) which are the most associated with attention-deficit/hyperactivity disorder (adhd)in the sample that has been confirmed diagnosis of adhd and sample with the same symptoms but not confirmed diagnosis of adhd. there are no reports of this kind in the norwegian population with adhd.

adhd is one of the largest diagnostic groups in psychiatric health care for children and adolescents in norway. in the guidelines laid out by the central authorities, adhd is to be prioritized. as can be seen by the attention this topic is given in the media, good diagnostics and treatment for this group are important for society as well as the individuals who suffer from this. early diagnosis, proper organization and appropriate treatment have a positive effect on the self-esteem and development of the person diagnosed as well as probable socio-economic benefits for society. adhd population shows significant pattern in socio-demographic relations and comorbidity according to the population that is referred to community mental health clinic due another types of psychiatric conditions. in terms of comorbid states odd and ocd are most associated with adhd . the study indicates prevalence of adhd children (74%) who met criteria for adhd, combined type (adhd-c, both inattention and hyperactivity-impulsivity symptoms) and the existence of generally low iq measures with mean value of 85 points. in terms of comorbid states generally were found in almost whole adhd group (93 %) compared to half of the non-adhd group. disruptive behaviour disorder, anxiety /stress related disorder and encopresis /enuresis shows significant difference between the groups. other comorbid conditions show no significant differences. social dysfunctions were found in four of five children.

Eligibility criteria:
inclusion criteria: * clinical symptoms related on diagnosis of adhd * age from 6-17 years exclusion criteria: * retardation * somatic disorder

Keywords: icd 10 attention-deficit-hyperactivity-disorder (adhd) comorbidity social-demographic profile
traditional versus goal directed perioperative fluid therapy in high risk patients

Conditions: Postoperative Complications

Summary: is goal directed fluid therapy reducing postoperative complications in comparison to traditional fluid therapy for gastro surgical asa iii/iv patients? the investigators compare two groups of patients: one group receives goal directed fluid therapy guided by lidcorapid stroke volume variation (svv), the other gets the "traditional" fluids, ie the current regime.


Eligibility criteria:
inclusion criteria: * adult asa class iii \& iv (high risk) patients * \>18 years * scheduled for gastrointestinal surgery involving laparotomy * both elective and emergency cases exclusion criteria: * atrial fibrillation * mental impairment, unable to give informed consent * severe aortic or mitral stenosis * type of surgery: liver surgery, transthoracic oesophagectomy

Keywords: goal directed fluid therapy perioperative fluid therapy lidcorapid postoperative outcome open abdominal surgery
epidemiology of septic shock in medical or polyvalent icu in the north-east region of france

Conditions: Severe Sepsis; Persistent Hypotension

Summary: the epidemiology of this study aims and outcome of patients with septic shock in the intensive care unit (or versatile) of the north-east region in france as well as the modalities of care.


Eligibility criteria:
inclusion criteria: * patients in septic shock defined by hypotension that is not reversed by volume resuscitation and requires the use of vasopressors. exclusion criteria: * none