Kornimate/medical-research-clean huggingface dataset:
a study of treatment patterns and clinical outcomes in patients diagnosed with acute myeloid leukemia who received mylotarg in the real-world

Conditions: Leukemia, Myeloid, Acute

Summary: the aim of this observational study is to describe treatment patterns and effectiveness outcomes in a sample of oncology patients treated for aml with mylotarg through up to two additional relapsed/refractory (r/r)-based lines of therapy (through third-line therapy). the study will use united states oncology electronic medical record (emr) data. all study data are secondary data and will have been collected retrospectively from existing clinical data originally collected as part of routine care.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of acute myeloid leukemia (aml) on or after 01 december 2014 through clinical research nurse (crn) review of provider documentation of aml diagnosis in the medical record; * receipt of mylotarg at any point during first three lines of therapy following initial aml diagnosis; * age greater than or equal to 18 years at initial diagnosis of aml. exclusion criteria: - record of 1 or more of the following confounding diagnoses at any point before or after aml diagnosis: acute lymphoblastic leukemia; acute promyelocytic leukemia, aggressive systemic mastocytosis; hypereosinophilic syndrome and/or chronic eosinophilic leukemia; dermatofibrosarcoma protuberans; gastrointestinal stromal tumors.

Keywords: aml mylotarg gemtuzumab
the dual impact of homocysteine and cholesterol on cognitive functions

Conditions: Hypercholesterolemia; Cognitive Dysfunction; Hyperhomocysteinemia

Summary: the study evaluates if the relationship between total serum cholesterol is dependent on the total serum homocysteine. fasting blood samples will taken from participants and two batteries of cognitive scales will be used to asses any cognitive decline.

the relationship between total serum cholesterol (tc) levels and cognition remains wily. some studies suggested that high tc level in old peoples is associated with a decreased risk of dementia. other studies have indicated that hypercholesterolemia may be a risk factor for cognitive decline and alzheimer's disease (ad). but a recent study published in 2014 by cheng and colleagues, showed that, an inverse u-shaped relationship between total cholesterol level and cognitive score was found only in participants with normal homocysteine levels. indicating that both low and high total serum cholesterol were associated with lower cognitive scores, ended to the relationship between cholesterol levels and cognitive function depends upon homocysteine levels, suggesting an interactive role between cholesterol and homocysteine on cognitive function in the elderly peoples. the effect of high serum homocysteine (hhcy) levels on cognition was overwhelming regardless of the serum cholesterol levels but in peoples with normal homocysteine levels, both low and high cholesterol levels may be detrimental to cognitive health.

Eligibility criteria:
inclusion criteria: * fifty hundred participants * participants are of both genders * aged 55 years old and over. exclusion criteria: * patient with dementia. * renal and hepatic impairment. * parkinson's disease. * cerebrovascular stroke. * patient with chronic medical problems. * patients on statins.

Keywords: cholesterol dementia homocysteine cognitive dysfunctions
the treatment of the median nerve for the elimination of the symptoms associated with the carpal tunnel syndrome

Conditions: Compression Neuropathy, Carpal Tunnel

Summary: in carpal tunnel syndrome,trigger points are often found in the biceps muscle,in the aponeurosis of the biceps and in the pronator teres muscle. we hypothesise that by eliminating these trigger points,using ischemic compressions, may diminish the symptoms.

using one thumb on the other,the pressure is applied 10 seconds on each trps.the treatment is done on each visit for a total of 15(without charge).

Eligibility criteria:
inclusion criteria: * between 20 and 60 years old, * numbness in the hand affecting the thumb, the index finger, the middle finger and half the ring finger, * to have suffered from discomfort on a daily basis for at least three months and to agree to a course of 15 chiropractic treatments at no cost. exclusion criteria: * history of upper limb or neck surgery, * pregnancy and systemic pathologies possibly related to cts, such as hypothyroidism, diabetes and rheumatoid arthritis.

Keywords: ischemic compression;carpal tunnel syndrome
prone positioning for brain-injured patients with severe ards (probrain)

Conditions: Cerebral Blood Flow

Summary: prone position (pp) is a key component to treat hypoxemia in patients with severe acute respiratory distress syndrome (ards). however, most studies evaluating pp effects in patients with ards exclude those with brain-injuries without providing any medical evidence. this prospectice observational study aimed to investigate if prone positioning leads to significant modification of cerebral perfusion in brain-injured patients with ards.


Eligibility criteria:
inclusion criteria: * adult's patients suffering from brain injuries * patients neurologically monitored with tcd * patients requiring prone position for severe ards exclusion criteria: * pregnant women * patients with contrindication to prone position

Keywords: prone position acute respiratory distress syndrome intracranial pressure
the effect of acupuncture on anxiety and working memory

Conditions: Memory Impairment; Anxiety

Summary: this study endeavors to examine the relationship between acupuncture, anxiety, and performance on a test of working memory. in the study, all participants will complete the state-trait anxiety inventory (stai) survey to determine how anxious they are at the moment and how anxious they tend to be in general. then ½ of subjects will receive acupuncture for 20 minutes and ½ will rest quietly for 20 minutes. after this period, all subjects will again complete the stai survey. then all subjects will complete the automated operations span task (aospan) which is a computerized test of working memory. statistical analysis will be performed to determine if acupuncture had any effect on state-level anxiety and on performance on the aospan.


Eligibility criteria:
inclusion criteria: * undergraduate university student * fluent in english * willing to receive acupuncture * aged 18-30 * in good health * not pregnant * not breastfeeding exclusion criteria: * not an undergraduate university student * not fluent in english * unwilling to receive acupuncture * under 18 years of age or older than 30 years of age * chronic disease * pregnant * breastfeeding

Keywords: acupuncture anxiety memory
physiological effects of lung impedance tomography-guided and plat pressure-guided phigh during aprv in patients with ards

Conditions: ARDS: Acute Respiratory Distress Syndrome

Summary: this study aims to investigate the effects of eit-guided and pplat-guided phigh settings on regional ventilation and perfusion in ards patients during aprv, while also examining the impact of different phigh settings on gas exchange, respiratory mechanics, and hemodynamics.


Eligibility criteria:
inclusion criteria: * diagnosed with ards according to the 2023 global new definition of ards. * age ≥ 18 years. exclusion criteria: * severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · contraindications for eit, such as chest wound dressing, pacemaker implantation, defibrillator use, etc. * pulmonary interstitial disease. * uncorrected shock of various types. * intracranial hypertension. * pregnant and postpartum women.

Keywords: ards aprv eit phigh
stereolithographic technique for dentures

Conditions: Mouth Edentulous; Jaw Edentulous

Summary: the aim of this observational study is: producing complete dental prosthesis with the aid of cad-cam (computer aided design \& manufacturing) - 3d printing (stereolithography) technology - using as printable material poli(methylmetacrylate) - pmma - with nano tio2 nanoparticles composite completely characterized.

in order to improve complete dentures fabrications an experimental model for optimizing the composite material and the execution technique for the 3d printed dental prosthesis was developed. * a new polymer - nano-tio2 composite system for dentures printing was obtained by adding 0,4-1%tio2 nanoparticle in the commercially available e-dent 100 (envisiontec, germany). * the new polymer was completely characterized and biocompatibility tests were perform. * a stereolithography technique was set-up for cad-cam complete dentures manufacturing. * 3d printed dental prosthesis will be inserted to a number of 35 complete edentulous patients from a target group; * clinical follow-up at 6, 12 and 18 months and quality assessment of the dentures will be recorded in a specific chart. * a statistical evaluation of data recorded during the entire follow-up period will be performed.

Eligibility criteria:
inclusion criteria: * patients requiring mobile or removable dentures after establishing diagnosis and treatment plan, following initial clinical and laboratory examinations, * persons having mental competence, decision-making capacity, legal competence. * patients willing to accept complete denture treatment. * patients with good systemic health, able to attend all the follow-up sessions. * patients accepting the participation in the study, including the 18 months follow-up and signing the consent form. exclusion criteria: * patients do not agree the cad-cam technique for denture manufacturing. * patients refusing participation in the study and signing consent form. * patients not willing removable dental restorations. * patients not willing to participate at 18 months follow-up evaluation.

Keywords: complete denture pmma stereolithography
pulmonary hypertension institutional registry

Conditions: Death

Summary: the purpose of this study is to create a registry of patients with pulmonary hypertension who received medical care in the hospital italiano of buenos aires.

the institutional registry of pulmonary hypertension includes patients prospectively with incident pulmonary hypertension, and excludes type ii pulmonary hypertension. it also includes prevalent cases from our hmo who had diagnosis prior the beginning of the registry.

Eligibility criteria:
inclusion criteria: * more 17 * pulmonary hypertension * systolic pulmonary pressure \>40 mmhg measured in a doppler echocardiogram, * systolic artery pressure \<25 in a pulmonary angiography exclusion criteria: * non accept to participate * pulmonary hypertension type ii (left cardiac disease)
clinical cohort study - intercath

Conditions: Coronary Artery Disease; Coronary Disease; Coronary Syndrome; SCAD; Cardiovascular Diseases

Summary: within a cad patient cohort there is a wide variability of clinical manifestation and severity of coronary disease. distinct determinants that would explain the variety of cad phenotypes with differing prognosis are yet undiscovered. aim of this study is to find genetic variants, biomarkers, and clinical cardiovascular risk factors that relate to specific coronary artery disease phenotypes and related pathologies in a patient population.

atherosclerotic coronary artery disease (cad) is one of the leading causes of death in industrialized countries and accounts for a high lifetime prevalence. within a cad patient cohort there is a broad inter-individual difference with regard to clinical manifestation and severity of disease, e.g. stable angina vs. acute coronary syndrome, calcified vs. thrombotic coronary lesions or one vessel vs. complex three vessel disease or left main stenosis. thus, depending on the cad phenotype there is a broad difference in cad patients' prognosis. similarly, other non-atherosclerotic coronary pathologies such as spontaneous coronary dissection (scad) are related with devastating illness in mainly young patients. for these patients there is an unmet need in the knowledge of epidemiology, presentation, current management and outcome. aim of this study is to discover genetic variants, biomarkers, and clinical cardiovascular risk factors that relate to specific cad (and related coronary pathologies) phenotypes in a national patient population. this may allow an improvement of individualized risk stratification and contribute to discover pathways in the pathogenesis and open the avenue for potential therapeutic targets.

Eligibility criteria:
inclusion criteria: * individuals with a minimum age of 18 years * any patient with an available complete coronary angiography * ability to provide written informed consent in accordance with good epidemiological practice and local legislation exclusion criteria: * physical or psychological incapability to take part in the study * known anaemia (hemoglobin \< 7.5 g/dl)
grading versus classic inferior oblique anterior transposition in patient with asymmetric dissociated vertical deviation

Conditions: Asymmetric Dissociated Vertical Deviation

Summary: purpose: to determine the surgical outcomes of the grading versus classic inferior oblique anterior transposition (ioat) technique in treatment of patients with asymmetric dissociated vertical deviation (dvd) and inferior oblique overaction (iooa). methods: in this randomized clinical trial, a total of 38 patients with iooa of \>+1 and a minimum dvd difference of 5pd between their two eyes will be included. comprehensive ophthalmic examinations including visual acuity assessment, measurements of noncyclo- and cycloplegic refraction as well as ocular deviation, biomicroscopic and funduscopic evaluation will be performed at baseline and repeated three months after the surgery. the function of extra ocular muscles will be evaluated by duction and version movements denoting from -4 (underaction) to +4 (overaction) grades. also, iooa will be graded as +1 to +4 according to the covering of the cornea under the superior eyelid during the ocular movement towards supra-nasal direction. the difference of dvd≥5pd between two eyes will be considered as asymmetric dvd. all patients will be randomized in the two groups to undergo ioat surgical procedure; in the classic group, io muscle will be sutured to the sclera at the level of inferior rectus (ir) insertion at its temporal border, without considering the asymmetric dvd between the two eyes; while in the grading group, io muscle of the eye with more severe dvd will be sutured at the level of ir insertion and io muscle of the eye with lower magnitude of dvd will be sutured 2mm posterior to the sclera to consider the preoperative dvd difference between the two eyes.


Eligibility criteria:
inclusion criteria: - overaction of inferior oblique muscle ≥+1 and asymmetric dissociated vertical deviation \>5pd between their two eyes. exclusion criteria: * mental retardation * nystagmus * cerebral palsy * history of ptosis and previous surgery on any cyclovertical muscle * restrictive or paralytic ocular deviations * inability to maintain fixation by each eye * best corrected visual acuity \<20/200 * ocular and/or systemic anomalies * follow up less than three months
feasibility of a cognitive intervention for youth post concussion

Conditions: Mild Traumatic Brain Injury; Concussion, Mild

Summary: the purpose of this study is to evaluate the feasibility and effects of a cognitive intervention for youth following concussion

concussion, a form of mild traumatic brain injury, is one of the most commonly reported injuries in youth. while most recover quickly, a substantial subset (30-58.5%) report symptoms that persist at one month with a reported 11-14% who continue to report symptoms beyond three months. currently, there are no evidence-based guidelines for treatment that address occupational (meaningful activity) concerns for youth who are slower to recover post-concussion. it is postulated that a top-down rehabilitation approach with metacognitive strategy training as the core of the intervention might be effective.the cognitive orientation to occupational performance (co-op) approach is a metacognitive strategy training approach with a growing body of literature supporting it's value in improving participation in meaningful activity and achieving self-selected occupation-based goals for adults with brain injury and youth with moderate to severe brain injury.given the long-term occupational concerns in youth with persistent post-concussion symptoms, and the lack of evidence based interventions for these youth, it is hypothesized that the co-op approach may facilitate return to meaningful occupation in this population.

Eligibility criteria:
inclusion criteria: * concussion diagnosed by a physician; * presence of at least one post-concussion symptom for three months or more; -experiencing challenges with usual daily activities secondary to post-concussive symptoms; * able to identify four or more occupation-based goals; * 12-18 years of age; * no concurrent serious medical or psychiatric diagnoses. * has a parent who can support participation and participate in a post intervention interview exclusion criteria: * non english speaking

Keywords: pediatrics case series feasibility
cognitive status, fatigue and inflammation in patients with immune thrombocytopenia (itp)

Conditions: Chronic Immune Thrombocytopenia; Primary Immune Thrombocytopenia; Adult Immune Thrombocytopenia

Summary: this is a multi-center, hospital based, cross-sectional study based on data from patient medical records, including laboratory results. the study will include adult patients with chronic (\> 1 year duration) primary immune thrombocytopenia (itp) only. patients will be identified based on a laboratory confirmed diagnosis of itp in the medical records, where there is also a physician-confirmed diagnosis of primary itp. if patients consent to take part in the study, a routine clinical visit will also serve as the study visit. all study participants will have a routine blood test as part of their standard clinical care at the study visit, and this same procedure will be used to collect supplementary blood samples to assess a variety of biomarkers. data will be collected using a combination of chart review, clinical outcome assessment administration, and laboratory results through blood tests.


Eligibility criteria:
inclusion criteria: * patient diagnosed with chronic (itp with \> 1 year duration) primary itp living in the usa or the uk: * on itp pharmacologic treatment, regardless of last platelet count (below or above 100 x 10\^9 counts/l); * patients in remission as per their most recent blood test (platelet count \>100 x 10\^9 counts/l) and without itp-specific treatment for less than 1 year * adult patient who are 18 years or older at index date * patient who has received at least one initial first line therapy (corticosteroids \[cs\]/ intravenous immunoglobulin \[ivig\]/anti d) with initial response (platelet count ≥ 50 x 10\^9 counts/l) as of index date exclusion criteria: * secondary itp * patients in remission as per their most recent blood test (platelet count \>100 x 10\^9 counts/l) and without itp-specific treatment for 1 year or more * patients with recent or active infection recorded 14 days or less before index date; patients with uncontrolled chronic infections or who were recently diagnosed with a chronic infection (≤14 days of index date). * patients with vaccination in 28 days before index date * patients treated with rilzabrutinib on or before index date
s-icd electrode registry

Conditions: ICD Malfunction; Sudden Cardiac Death

Summary: the subcutaneous implantable cardioverter defibrillator (s-icd) is established in the prevention of sudden cardiac death, but recently a defect of the electrode's sense-b component was reported in some patients. this lead to inadequate shocks due to noise. the cause and incidence of this defect are unknown. the manufacturer issued a warning regarding this defect and a possible premature depletion of the battery in some device. independent data on the incidence of these issues is limited. further data is needed to better understand the risk of these complications.

the s-icd therapy is an established treatment for primary and secondary prevention of sudden cardiac death. recently, a report was published about a previously described complication of the electrode, in which a defect of the so-called sense-b component is reported in a few affected patients. the defect of this component of the electrode leads to electrode noise and subsequent inadequate shocks. the cause of the defect and the incidence are currently unknown. the manufacturer boston scientific has issued a warning and advisory. in addition to this advisory regarding the electrode of the s-icd, there is also an active warning from the manufacturer regarding the possible premature exhaustion of the s-icd battery. this is caused by an error in the manufacturing process of approximately 40,000 devices produced in 2018. the manufacturer estimates the incidence of premature battery exhaustion to be 4-15% within 5 years. independent data on the incidence of premature exhaustion of these devices were initially scarce. the investigators conducted a retrospective data query in 2021 to capture the incidence of battery exhaustion at that time. the incidence was 3.7% after 5 years. the average follow-up time was only 3 years. the incidence of premature exhaustion increased significantly after 3 years, so data with a longer follow-up period is urgently needed. given that these data already show that the incidence of premature exhaustion increases significantly after 3 years and the observation period in the retrospective data was on average slightly under 3 years, a further query of the existing clinical data on the battery as part of this register is also planned. this would allow for a more accurate estimate of the risk of premature battery depletion.

Eligibility criteria:
inclusion criteria: - status post s-icd insertion exclusion criteria: - no available follow-up data beyond 2 weeks after insertion

Keywords: subcutaneous cardioverter-defibrillator s-icd electrode malfunction lead failure battery depletion
low-dose computer tomography in follow-up of soft tissue sarcomas

Conditions: Sarcoma,Soft Tissue

Summary: the goal of this interventional study is to compare sensitivity of regular chest x-ray to ultra-low-dose computed tomography to find pulmonary relapse in follow-up of soft tissue sarcoma. the main question\[s\] it aims to answer are: * is ultra-low-dose computed tomography more sensitive than regular chest x-ray to find pulmonary relapse? * does ultra-low-dose computed tomography detect the most fast-growing pulmonary metastases earlier than regular chest x-ray? participants will have seven ultra-low-dose computed tomography imagings in addition to simultaneous routine protocol of chest x-rays. participants therefore work as their own controls.

after primary treatment with curative intent for soft tissue sarcoma, patients fulfilling the inclusion criteria and giving informed consent are enrolled. in study protocol patients have their regular chest x-ray once in two months plus ultra-low-dose computed tomography imaging is repeated seven times during the first two years of follow-up. after two years patients without detectable metastases continue in regular follow-up program. the aims of this prospective comparative study are to investigate whether ultra-low-dose computed tomography is more accurate than chest x-ray in soft tissue sarcoma and especially whether the most fast-growing pulmonary metastases could be detected earlier.

Eligibility criteria:
inclusion criteria: * primary high grade soft tissue sarcoma with no metastases at diagnoses or during treatment and treatment with curative intent. exclusion criteria: * metastases at diagnoses or during treatment