Kornimate/medical-research-clean huggingface dataset:
vitamin d status in children with sickle cell disease living in lyon, france

Conditions: Vitamin D Deficiency; Sickle Cell Disease

Summary: vitamin d deficiency may be under-diagnosed in sickle cell disease french children. therefore, the investigator need an epidemiologic study about the prevalence of vitamin d deficiency in this specific population. there are not specific guidelines neither testing nor treatment. the investigator propose to test vitamin d status in all children with sickle cell disease who are consulting their referring haematologist doctor or in the emergency ward.


Eligibility criteria:
inclusion criteria: * children: under 18 years old * sickle cell any genetic type homozygous or composite heterozygous * to receive an assessment independently of the study, during a presentation to the emergency ward and/or a follow-up consultation by the hematologist * no parental opposition signed by at least one parent/legal representative and no child opposition * social security beneficiary exclusion criteria: * history of hematologic grafting

Keywords: vitamin d deficiency prevalence rate vitamin d level children with sickle cell disease
examining the effectiveness of multidisciplinary care teams in improving outcomes for breast cancer patients

Conditions: Breast Cancers; Breast Cancer Female; Breast Cancer Stage I

Summary: to compare clinical outcomes, patient-reported measures (proms), and healthcare utilization between standard care with or without an mdct in a cohort of women treated for breast cancer.

this single-center, prospective interventional trial evaluates the effectiveness of multidisciplinary care teams (mdcts) in improving outcomes for newly diagnosed breast cancer patients at hayatabad medical complex, peshawar. the study enrolled 73 participants from may 2021 to april 2024, with follow-up sessions every six months for up to two years. participants were randomly assigned to two groups: group a (n=37): received care through mdcts, which included radiologists, oncologists, and surgeons collaborating to create personalized treatment plans and monitor patient progress. group b (n=36): received standard therapy according to existing institutional protocols. the study assesses multiple outcomes, including \*\*disease-free survival (dfs), overall survival (os), recurrence rates, complication rates, patient-reported outcomes (pros), quality of life (measured via sf-36), and healthcare utilization. statistical analyses include kaplan-meier survival curves, log-rank tests, cox proportional hazards regression models, repeated-measures anova, and linear regression models to identify predictors of survival and quality of life. the study protocol was approved by the institutional review board (irb) and complies with the declaration of helsinki. all participants provided informed consent prior to enrollment.

Eligibility criteria:
inclusion criteria: all female patients, diagnosed with breast cancer exclusion criteria: previous treatment for breast cancer, concurrent enrollment in another clinical research, and serious medical conditions that could affect study outcomes

Keywords: breast cancer mdct disease free survival quality of life outcome
comparison of two methods of transnasal sphenopalatine ganglion block

Conditions: Sphenopalatine Ganglion Block

Summary: the transnasal sphenopalatine ganglion block(spgb) is administered to patients with facial or head and neck pain. in the transnasal approach, the drip and topical methods are frequently used. we compared facial temperatures and vas after transnasal spgb.

the objective of this study was to compare facial temperatures and visual analogue scale (vas) between drip method and topical method of transnasal sphenopalatine ganglion block (spgb). the transnasal spgb is administered to patients with facial or head and neck pain. in the transnasal approach, the drip and topical methods are frequently used. we compared facial temperatures and vas after transnasal spgb. medical records of 74 patients who visited the pain clinic and underwent transnasal spgb were retrospectively reviewed. a total of 156 transnasal spgb were performed. the patients were divided into the drip-method and topical-method groups. facial temperatures were measured in six areas of the right and left forehead, maxilla, and mandible before and 30 min after completion of the transnasal spgb. temperatures were compared before and 30 min after spgb in each group and between the two groups. vas scores were compared at same times of spgb in each group and between the two groups.

Eligibility criteria:
inclusion criteria: (1) age over 20 years ; (2) head and neck pain; (3) pain score \> 4 on the vas in the head and neck; and (4) having undergone a transnasal spgb and having had facial temperatures measured. exclusion criteria: (1) patients with a history of head and neck surgery, (2) treatment with a vasodilator or vasoconstrictor, (3) contraindication to treatment using a transnasal approach, (4) clinically significant systemic disease or any reduced organ failure, and (5) missing data.
acupuncture improves sleep in patients undergoing cardiopulmonary bypass

Conditions: Heart Valve Diseases; Cardiopulmonary Bypass

Summary: due to various causes, such as brain impairment, environment changes, anxious,et al. patients, who undergo cardiopulmonary bypass, often suffer from poor quality of sleep. in chinese traditional medicine, acupuncture can improve the quality of sleep in patients with sleeping disorder. but it remains acupuncture could improve the quality of sleep in patients with heart operations.

60 patients are divided into three groups. control group: no any intervention; experiment group 1: acupuncture are used in patients before cardiac operation; experiment group 2: acupuncture are used through all the course in hospital. before operation, before discharge, one month after operation, two month after operation, the quality of sleep are evaluated. and comparisons will be made in three groups.

Eligibility criteria:
inclusion criteria: * aging:18yr--65yr * cardiopulmonary bypass * nyha ≤ii and ef≥50% * not illiterate person exclusion criteria: * neurological disease,mentality disorder * abuse of alcohol * long history of smoking * sleep disorder before admitting to hospital

Keywords: cardiopulmonary bypass sleep acupuncture
a relative bioavailability study of hrs9531 in healthy subjects

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to evaluate the relative bioavailability of the new formulation of hrs9531 injection between the original formulation of hrs9531 injection.


Eligibility criteria:
inclusion criteria: 1. ability to understand the trial procedures and possible adverse events, be able and willing to provide a written informed consent; 2. age 18-45 years on the date of signing informed consent (inclusive); 3. body weight ≥50 kg for male and 45 kg for female, body mass index (bmi) within the range of 19.0-26.0 kg/m2 (inclusive); 4. subjects with good general health, no clinically significant abnormalities. exclusion criteria: 1. with previous major organ diseases, including but not limited to neuropsychiatric, cardiovascular, digestive, respiratory, urinary, endocrine, blood, immune and other diseases, are judged by researchers to be unsuitable for the study; 2. had a severe trauma or major surgery within 6 months prior to screening, planned to undergo surgery during the trial period; 3. participants in clinical trials of any drug or medical device in the 3 months prior to screening; 4. blood donation history or blood loss ≥400 ml within 3 month or ≥200 ml within 1 month before screening, or received blood transfusion within 3 months; 5. allergic constitution includes severe drug allergy or history of drug allergy; 6. hepatitis b surface antigen (hbsag), hiv antibody detection, hepatitis c virus antibody (hcvab), treponema pallidum specific antibody detection, positive; 7. breast-feeding women; 8. the investigator considers that the subject has any other factors that would make it inappropriate to participate in this study.
the efficacy and safety of early vitamin ad supplementation in very preterm infants

Conditions: Efficacy and Safety

Summary: bronchopulmonary dysplasia (bpd) is the most prevalent longterm morbidity among surviving extremely preterm infants and has a multifactorial etiology. bpd is associated with later risk of reactive airways disease, such as asthma, post neonatal mortality and adverse neurodevelopmental outcomes.retinopathy of prematurity (rop) is a common retinal neovascular disorder and a major cause of vision impairment or blindness in preterm infants, even with aggressed current standard care.accumulating epidemiologic evidence suggests that vitamin d (vd) deficiency or insufficiency is associated with respiratory disease and metabolic bone disease in premature children.vitamin a (va) plays an integral part in lung growth and differentiation. va is an essential micronutrient for normal visual function. our prospective double-blinded randomized controlled trial will include infants born at \<32 weeks' gestation and admitted to six tertiary nicus in china. infants in the intervention (vitamin ad drops) group will receive the daily dose va at 1500 iu/day with vd 500 iu/day, added to their enteral feeds in drop form as soon as minimal feeding was introduced, and continued to 28 days or discharge. infants in the control group will receive an equivalent volume of a placebo solution. following informed consent, enrolled infants will be randomly allocated to the control or vad group. the primary outcome is bronchopulmonary dysplasia (bpd) , rop, or metabolic bone disease and the secondary outcomes are mortality; nec ≥ stage 2; ; late-onset sepsis; weight gain, change in weight, increase in length, increase in head circumference; time to full enteral feeds; and number and type of critical incident reports.


Eligibility criteria:
inclusion criteria: * gestational age\<32 weeks, * \<96 hours of age exclusion criteria: * genetic metabolic diseases; * congenital major abnormalities; * congenital non-bacterial infection with overt signs at birth; * terminal stage of illness (ph \ 2 h); * ≥ grade iii intracranial hemorrhage; * lacking parental consent.
participatory design of patient-centered depression and diabetes care

Conditions: Depression; Type 2 Diabetes Mellitus

Summary: the burden of diabetes is anticipated to grow yet the proportion of adults whose diabetes is controlled is decreasing over time. this project can have a significant public health impact because we are refining and pilot testing a primary-care based intervention aimed at improving patient engagement and function which are critical components of diabetes care and are associated with improved glycemic control, lower disease-related health-care expenditures, and reduced mortality.


Eligibility criteria:
inclusion criteria: 1. 18 years and older 2. a current diagnosis of type 2 dm 3. hba1c 7% 4. current prescription for an oral hypoglycemic agent 5. able to communicate in english 6. willing to give informed consent exclusion criteria: 1. acutely suicidal or psychotic (patients will not be randomized and pi or physician covering for pi will be paged immediately) 2. significant cognitive impairment at baseline (a total score on mini-mental state examination (mmse) 21) 3. markedly shortened life expectancy (diagnosis of metastatic cancer, end-stage renal disease on dialysis, or nyha class iii or iv congestive heart failure)
effectiveness of vestibular electrical stimulation in vestibular rehabilitation

Conditions: Vestibular Diseases; Vestibular Disorder; Vestibular Vertigo

Summary: this study aimed to evaluate the effectiveness of the vestibular rehabilitation program applied to patients with chronic unilateral vestibular hypofunction and the vestibular electrical stimulation applied to the trapezius muscles and cervical paravertebral muscles along with the rehabilitation program.

this study included 40 patients with unilateral vestibular hypofunction findings, aged between 18 and 65, and whose unilateral vestibulo-ocular reflex (vor) gain for any semicircular canal was below 0.7 based on the video head impulse test (vhit) test, were randomized into two groups. while one group underwent a supervised vestibular rehabilitation program for 4 weeks, the other group received 80 hz high frequency transcutaneous vestibular electrical stimulation (ves) in addition to the supervised vestibular rehabilitation program. the treatment was applied to each group, 3 days a week, for a total of 12 sessions. detailed musculoskeletal system examinations and vestibular system examinations of the included patients were performed, and sociodemographic characteristics (age, gender, body mass index (bmi), education level) were recorded. both groups were tested before treatment and at the end of the 4th week, dizziness disability inventory (dhi), visual analogue scale (vas), berg balance scale (bbs), timed up and go test (tug), activity-specific balance and confidence scale (abcs), beck depression inventory (bdi), beck anxiety inventory (bai) and static posturography.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-65 * patients who were evaluated by a neurologist, physical medicine and rehabilitation specialist and otorhinolaryngologist and diagnosed with chronic unilateral vestibular hypofunction and have findings of chronic unilateral vestibular hypofunction * patients whose vor gain for any unilateral semicircular canal based on vhit test is below 0.7 * patients who volunteered to participate in the study and signed the consent forms exclusion criteria: * existing neurological or mental disorders * patients using vestibulosuppressant drugs * stroke, head trauma and other neurological diseases * patients with a history of brain surgery * patients with severely limited neck joint range of motion (those with a limitation of 45 degrees or more)

Keywords: vertigo rehabilitation tens
substance dependence satisfaction with care and quality of life

Conditions: Opiate Dependence; Alcoholism; Early Satisfaction With Substance Dependence Care

Summary: the subusqol cohort aimed to improve knowledge of the quality of ambulatory care, in particular the prognostic role of the early satisfaction with care on the change from baseline quality of self-reported health status in outpatients with alcohol or opioid dependence. it is a multicenter prospective cohort. satisfaction was assessed using a multidimensional self-administered and validated questionnaire during the early care process. in addition to measuring satisfaction and obtaining sociodemographic and clinical data, this study collected data on the self-reported health status at inclusion and 3, 6 and 12 months after inclusion.

early satisfaction with care was measured using the quality of care satisfaction questionnaire in outpatient consultation (eqs-c). data collected during the study included patient sociodemographic, clinical and health status characteristics, as well as physician characteristics. self-perceived quality of life was assessed using the generic sf-12 and a specific questionnaire in illness disease, the quality of life enjoyment and satisfaction questionnaire-short form (q-les-q-sf).

Eligibility criteria:
inclusion criteria: * outpatients who met the diagnostic and statistical manual, fourth edition (dsm-iv) criteria for alcohol dependence, opioid dependence, or both. * patients recruited from the french specialized addiction treatment centers where they began care. * patient agreement obtained exclusion criteria: * age lower than 18 years * inability to complete self-questionnaires

Keywords: satisfaction with care outpatient care self-reported health status alcohol dependence opioid dependence
toripalimab in combination with nab-paclitaxel for patients with metastatic or recurrent triple-negative breast cancer (tnbc) with or without systemic treatment

Conditions: Triple-Negative Breast Cancer

Summary: this multicenter, randomized, double-blind study will evaluate the efficacy and safety of toripalimab (js001) combined with nab-paclitaxel compared with placebo combined with nab-paclitaxel for first/second line treatment of metastatic or recurrent triple-negative breast cancer (tnbc).


Eligibility criteria:
inclusion criteria: metastatic or recurrent triple negative breast cancer (tnbc); * histologically confirmed diagnosis of tnbc characterized by estrogen-receptor negative (er-), progesterone receptor negative (pr-) and human epidermal growth factor-2 receptor negative (her2-); * eligible for taxane monotherapy; * no more than one line of chemotherapy in metastatic setting; * eastern cooperative oncology group (ecog) performance status of 0 or 1; * life expectancy of 12 weeks or more; * at least one measurable lesion per recist v1.1; * demonstrate adequate hematologic and organ functions as defined in the protocol exclusion criteria: prior treatment with taxane as first line treatment; * prior treatment with pd-1 antibody, pd-l1 antibody, pd-l2 antibody, or ctla4 antibody (or any other antibody acting on t cell co-stimulation or checkpoint pathway) * mri assessment during screening or previous imaging studies confirmed active or untreated brain metastases. patients previously treated with local treatment of brain metastases has been stable for ≥ 1 month, and have stopped systemic hormonal therapy (\>10 mg/d prednisone or equivalent) \> 4 weeks before randomization can participate in the study; * meningeal carcinomatosis; * pregnancy or lactation; * active hepatitis b or hepatitis c.
2nd ac+: new village model

Conditions: Aging; Hiv; Loneliness; Social Isolation

Summary: this study evaluates implementation of the village model to support older people living with hiv.

understanding that older people living with hiv are facing uniques challenges as they age (lack of peer set due to extreme loss during the aids epidemic, ongoing hiv and age stigma, high rates of multi-morbidity) this study explores the acceptability and feasibility of implementing the village model in central san diego. the village model started when several older members of boston's beacon hill realized they were aging and may need more help as they aged to thrive in their own homes. the village model involves members of a community paying annual fees to support a village administrator that organizes regular socialization events and helps coordinate needs of individual members using the skill sets of other members within the community. from that first experience a few decades ago, today over 200 villages exist across the country to enhance the ability of older adults to age in place. however limitations of this model exists that may threaten the long term implementation and sustainability of the village model. specifically the requirement to pay annual fees for an administrator, the lack of diversity (in age, race, sexuality etc), and difficulty in meeting member's needs in real-time. this project proposes to pilot the village model in central san diego and will implement the following adaptions to address limitations. members will not be required to pay annual fees but instead depend on a well-funded, long-established diverse organization (the san diego lgbt center) to serve as the administrator. this village will allow participation of persons within the community at all ages, race, economic status. lastly, the project proposes to pilot the acceptability of using a website to display and respond to community needs in real time. to achieve this, the investigators will 1) perform questionnaires to understand the needs in the community by collecting needs assessments. 2) the investigators will explore the meaning of community and explore barriers and facilitators of village model implementation. 3) lastly the investigators will pilot the village model using a website.

Eligibility criteria:
inclusion criteria: * lives in central san diego * consents to participate * willing to sign village social contract * no plans to move out of central san diego in the next year * speaks english exclusion criteria: * severely cognitively impaired as indicated by \< 10 on mini mental state examination * history of a violent felony or fraud in the past 10 years * not willing to consent to participation

Keywords: hiv aging loneliness social isolation multi-morbidity lgbt community
quantitative and qualitative mri study of steatosis in patients with metabolic steatopathy

Conditions: Overweight; Type 2 Diabetes; Obesity

Summary: this is a single centre prospective open-label, non-randomised pilot study whose aim is to identify mri parameters to better evaluate inflammation and liver fibrosis and thus, in the near future, to avoid the need for liver biopsy. to achieve this: * the mri study will be completed by adding two sequences: measurement of t1 and multiecho t2\*. the other data will be extracted from usual sequences. * part of the histological samples will be used for the weighted levels of fat and iron, and for the lipidomic study. * usual blood samples will be completed by samples for the serum library


Eligibility criteria:
inclusion criteria: * patients who have been informed about the research * patients with national health insurance cover * patients who are overweight (bmi \> 25) or have type 2 diabetes suggesting a disturbance of hepatic enzymes (asat \ twice normal values) after a complete hepatopathy assessment * obese patients with a hepatic anomaly (steatosis) revealed by imaging or biological assessment (asat \ twice normal values) who are eligible for bariatric surgery and a preoperative liver mri examination. exclusion criteria: * non-corrected coagulation disorder. * patients aged over 80 years * patients aged less than 18 years * patients without legal protection * patients with a contra-indication for mri (pacemaker, intraocular metallic foreign body, weight\>150kg) * patients without national health insurance cover

Keywords: patients present undergo bariatric surgery