Kornimate/medical-research-clean huggingface dataset:
south texas early prevention studies prek

Conditions: Childhood Obesity

Summary: the south texas early prevention study-prekindergarten (steps-prek4) was a cluster randomized trial (crt) of preschool children 4 years of age to test the effect of the bienestar/neema coordinated school health program (bn cshp) on childhood obesity prevalence prevention.

the steps-prek4 was a crt where preschools, embedded within elementary schools, were the unit of randomization, intervention, and analysis. the study was designed for two years of intervention (pre-kinder to kindergarten) and four data collection periods (fall 2018, spring 2019, fall 2019, and spring 2020). due to the covid-19 pandemic the study was stopped prematurely and only results from the first three periods will be presented. the two school districts where the study was conducted are located along the texas-mexico border in the county of hidalgo. these school districts were selected because of the high poverty and health risk-factors levels.25 the preschools have two grade levels with children 3 and 4 years of age. the present study targeted preschools with children 4 years of age. demographics of the two school districts were similar, 99% hispanic, 92% economically disadvantaged, and 42% identified as english as a second language.

Eligibility criteria:
inclusion criteria: * prek children * enrolled in psja and la joya isds exclusion criteria: * na

Keywords: prek children obesity prevalence
nursing homes on constipation and general comfort

Conditions: Constipation; Nursing Caries

Summary: the effect of reminiscence therapy on constipation applied to elderly individuals staying in a nursing home in giresun province

research; this study will be conducted to determine the effect of reminiscence therapy, given once or twice a week to elderly people living in nursing homes, on constipation by reducing stress levels. it is thought that the results obtained will provide evidence for reducing constipation, which significantly limits life. patients who complain of constipation at the nursing home elderly care and rehabilitation center, who voluntarily agree to participate in the research and who meet the sample selection criteria will be included in the study. patient information will be collected and the research pre-test, post-test and application will be carried out face to face.

Eligibility criteria:
inclusion criteria for the study: * those aged 65 and over, * able to answer all questions and be communicative, * scoring 24 or above from the mini mental test, * agreeing to participate in the research, * diagnosed with constipation by the institution physician and meeting the rome iii constipation diagnostic criteria, * there is no deterioration in skin integrity or infection in the abdominal area, * no diarrhea, * individuals without a history of abdominal surgery will be included in the study. exclusion criteria * psychiatric drug users, * those who score below 24 on the mini mental test, * those who do not meet the rome iii diagnostic criteria for constipation, * those with impaired skin integrity or infection in the abdominal area, * people with diarrhoea, * history of abdominal surgery those who refused to participate in the study

Keywords: the elderly constipation comfort reminiscence therapy
pillars4life trial

Conditions: Breast Cancer; Lung Cancer; Esophageal Cancer; Colon Cancer; Pancreatic Cancer; Liver Cancer; Renal Cancer; Bladder Cancer; Prostate Cancer; Ovarian Cancer; Cervical Cancer; Uterine Cancer

Summary: this study aims to explore whether cancer patients can benefit from completing the pillars4life online coping program. this randomized control trial will have half its subject completing the program and the other half receiving standard care in order to measure whether the program is beneficial in dealing with stress, anxiety, and particularly chronic pain that often accompany a cancer diagnosis.

subjects will complete three online surveys as part of the study. each subject who completes the first survey will be randomized to either the control group who receive standard care from their care team or to complete the 9-week pillars4life curriculum. subjects completing the pillars4life program will select a course day/time that works for them from those offered. each week the program will send an email approximately 15 minutes before class time with a link. subjects will click the link to go to the "classroom," where they will enter their name and phone number. the program will call the number provided and the subject will listen to the audio over the phone, while watching the guide and activities in the virtual classroom on their computer. each class will last about an hour. all subjects will complete two additional surveys, at approximately 9 weeks and 18 weeks after enrolling in the study.

Eligibility criteria:
inclusion criteria: * current pain level ≥3 and at least one prior score ≥3 on a 0-10 scale as reported in epic; * age ≥18 years * diagnosed with breast, gi, gu, gyn, or thoracic cancer * actively receiving care at the duke cancer center, durham regional hospital, or duke raleigh hospital * able/willing to have an online interaction with the pillars4life online core program curriculum * life expectancy ≥6 months * providing informed consent * able to read/write english. exclusion criteria: * none

Keywords: cancer stress chronic pain anxiety coping balance online course psychosocial support tools
protecting allies in risky situations

Conditions: Sexual Assault; College Drinking; Behavioral Changes

Summary: the current project will provide testing of a friend-based motivational interview (fmi) designed to reduce sexual assault risk. the study will address if the intervention minimizes the impact of alcohol on helping behavior, test whether drinking reduces intervention efficacy, and examine potential iatrogenic effects of the intervention.

the objective of the proposed study is to develop an innovative, friend-based motivational interview (fmi) that encourages and prepares friends to reduce sexual assault (sa) risk. delivered to pairs of friends (dyads), the fmi will be designed to foster collaborative efforts to increase readiness for, and decrease barriers to helping behavior, and to teach and plan together for assault prevention skills. as the role of alcohol has been under-addressed in sa prevention efforts, the fmi also will explicitly attend to how intoxication may serve as a barrier to friend intervention, and strategies for overcoming this barrier. the completion of this project's aims will yield a novel intervention that capitalizes on the natural resource of women's friendships to decrease risk for sexual assault - a pervasive public health problem affecting a substantial portion of young adult women in the u.s. twenty-four friend dyads will participate in the friend-based motivational interview (fmi) along with 24 wait-list control dyads (total of 48 dyads). the study will compare groups on outcomes at post-intervention and at bi-weekly 3 month follow-ups, and also examine within participant change. the study will focus on whether effects are in the expected direction and whether the strength of effect sizes are of practical magnitude. it is expected that participants receiving the fmi will demonstrate significant increases in readiness, and engagement in friend assault prevention behavioral skills (fapbs), and demonstrate decreases in perceived barriers, at post-intervention and over the 3-month follow-up. follow-up data will be utilized to provide a rich description of the role of alcohol in implementing fapbs, and whether the fmi reduces the impact of alcohol use. in exploratory analyses, it will be examined whether the intervention may be associated with decreased assault risk, as well as decreased drinking.

Eligibility criteria:
inclusion criteria: * female dyads who go out together at least once a week * undergraduates enrolled in a 4-year college or university * meet heavy episodic drinking (hed) criteria, 4 or more drinks in a single sitting, 2 or more times monthly exclusion criteria: not applicable
asymptomatic covid-19 infection among healthcare workers

Conditions: Immunologic Activity Alteration

Summary: to assess the seroprevalence of sars-cov-2 igg in health care workers in three university hospitals

the proposed study is a cross sectional study that will be carried out among hcws in three university hospitals namely kasr alaini , ain shams , and zagazeg hospitals, employing a quantitative survey. ii-study population participants will be the hcws at great risk of getting an infection which include those who are in direct contact with respiratory secretions. inclusion criteria age: from 25 to 60 years old department: physicians and nurses from the operating room, critical care department, emergency department, pulmonology department. the potential participants will be given an information sheet and time to review this information before informed consent is sought. after the potential participants have agreed to be enrolled in the study, an informed consent will be obtained by the investigator. iii- procedures and data collection: serum collection and interview a- detecting serum igg against sars-cov2 blood samples will be collected from the enrolled hcws. sample collection, processing, and laboratory testing will follow guidance from the world health organization.(5) the sensitivity and specificity reported by the manufacturer for igm are 88.2% and 99.0% respectively, and for igg are 97.8% and 97.9%. b- structured interview questionnaire a structured - interview questionnaire using closed ended question format will be used to obtain information on: 1. socio-demographic characteristics of the interviewees asking about age, sex, residence, education, occupation, department, job title, hospital name, medical experience in years, marital status, living with family, and having children or not. 2. history of medical conditions, and history of performing procedures with transmission risk (date, place, type, duration, and frequency), 3. the use of personal protection, i.e., wearing of n95 masks, gloves, and gown, and consistent handwashing. 4. in addition, information will be collected regarding any clinical signs or symptoms in the worker past 3 months, including fever, cough, shortness of breath, or radiographically confirmed pneumonia.

Eligibility criteria:
inclusion criteria: * age: from 25 to 60 years old * department: physicians and nurses from the operating room, critical care department, emergency department, pulmonology department. exclusion criteria: * pregnant * age over 60 years
hypermetabolism in als using six ree formulas

Conditions: Amyotrophic Lateral Sclerosis

Summary: introduction: about 50-60% of amyotrophic lateral sclerosis (als) is characterized by hypermetabolism, defined as 10% or more excess resting energy expenditure (ree) compared to theoretical values. harris and benedict's (hb) formula is the equation mainly used to predict ree, but others are also applied in current practice. the present study aimed to assess ree in als patients compared to control populations and to compare six formulas commonly used to predict ree. nutritional assessments were performed in als patients and in two control populations without hypermetabolism: healthy elderly people (control 1) and patients with non-restrictive-eating disorders (control 2). weight, height and body composition (by bioimpedance analysis) were assessed. ee was measured (mree) by indirect calorimetry and calculated (cree) using hb 1919 and 1984, world schofield, de lorenzo, johnstone and mifflin formulas. mann-whitney and chi2 tests were used to compare the equations.


Eligibility criteria:
inclusion criteria: * als patients * 18 years old or more * ic and nutritional assessment within 1.5 months * delay between diagnosis and ic \< 12 months exclusion criteria: -

Keywords: amyotrophic lateral sclerosis, resting energy expenditure predictive equation
outcomes of children after hospitalization in intensive care unit

Conditions: Renal Disease; Liver Diseases; Heart Diseases; Trauma Injury; Sepsis; Septic Shock; Pneumonia; Bronchiolitis

Summary: more than 10,000 children are hospitalized in an picu every year in canada. while most of them will survive their picu hospitalization and their critical illness, some children will not recover to their pre-illness level. some may develop behavioral, physical, emotional or developmental problems and difficulties at school. all these problems are elements that are part of the pediatric post-intensive care syndrome (pics-p). it is important to understand the elements (risk factors) that play a role in the development of pics-p. in canada, there is no systematic follow-up for children after they leave the picu. understanding what can cause pics-p (risk factors) and how much pics-p has an impact on children and their family is very important to the family well-being.

the pediatric post-intensive care syndrome (pics-p) is a newly developed conceptual framework that incorporates the constellation of morbidities that are increasingly recognized to affect children and their families after a critical illness. experts define pics-p as a new or worsening impairment in any of the following 5 domains of child health: physical, cognitive, emotional, social, or family. in contrast to well established follow-up programs in adults, there is currently a lack of systematic follow-up of picu survivors which prevents both the recognition and management of pics-p. the absence of granular, empirical data on the recovery of picu children impedes both the identification and management of pics-p. this project is a prospective canadian multicenter cohort study to identify risk factors of pics-p, develop and validate a predictive model for pics-p to detect at-risk children, characterize each domain of pics-p over two years post critical illness and uncover additional morbidities that are not captured using the current pics-p framework. this study will provide granular, empirical data on which to build developmentally appropriate and tailored screening, management, and intervention programs during and after picu to improve the global recovery of critically ill children and their family.

Eligibility criteria:
inclusion criteria: * children ≤18yo hospitalized in picu for ≥96 hours exclusion criteria: 1. gestational age \ 18 years at picu entry; 2. admitted for congenital heart surgery (followed in neuro-cardiac clinics in most centers); 3. anticipated life expectancy \<1year (e.g., active do not resuscitate status).

Keywords: pediatric intensive care unit picu
developmental and epileptic encephalopathy of genetic etiology: natural history through reuse of clinical data

Conditions: Developmental and Epileptic Encephalopathy

Summary: developmental and epileptic encephalopathy (dee) are a heterogeneous group of neurodevelopmental disorders linked to both epilepsy and its underlying etiology, independently of epileptiform activity. the creation of a database with retrospective follow-up of a large number of patients on a national scale will enable better knowledge of specific biomarkers, and thus a better classification and understanding of the natural evolution of dee according to their etiology. this will enable better, more personalized therapeutic management of patients, depending on etiology and the presence or absence of these biomarkers. the investigators will also be able to draw up management recommendations, which are currently non-existent.


Eligibility criteria:
inclusion criteria: * diagnosis of developmental and epileptic encephalopathy * registered with or benefiting from a social security scheme. exclusion criteria: * opposition of the patient or his/her parents to the re-use of data in the context of this study * person subject to a safeguard of justice measure
philani home-based nutrition intervention program

Conditions: Child Weight

Summary: malnourished children and babies with birth weights under 2500 grams are at high risk for negative outcomes over their lifespan. philani, a paraprofessional home-visiting program, was mounted in neighborhoods in three townships in cape town, south africa, from 2002 to 2004 to improve nutritional outcomes. one mentor mother was recruited from each of 37 neighborhoods. mentor mothers were trained to conduct home visits to weigh children and to support mothers to problem-solve life challenges, especially around nutrition. households were randomly assigned on a 2-to-1 ratio to the philani program or to a standard care condition. children were evaluated over a 1-year period. the investigators hypothesized that children in the intervention would gain more weight than children in the control.


Eligibility criteria:
inclusion criteria: * mother or caregiver * with child under 5 years of age and malnourished (malnourished if less than 2 standard deviations below the world health organization normative mean weight for the child's age exclusion criteria: * no malnourished children under care * malnourished children not living in household

Keywords: nutrition child weight undernourishment mentor mother south africa
single-dose nicotine pharmacokinetics with three oral nicotine replacement products. a study in healthy smokers.

Conditions: Tobacco Dependence

Summary: single-dose nicotine pharmacokinetics with three oral nicotine replacement products.

the study is a single-dose, randomized, crossover study with 24 subjects (all subjects will receive all treatments). the investigational products will be 6 mg, 4 mg and 2 mg nicotine medicated gum given as single doses at separate treatment visits. periods without nrt, lasting for at least 36 hours, will separate treatment visits. blood for pharmacokinetic analyses will be drawn before, and at 2.5, 5, 7.5, 10, 15, 20, 30, 45, and 60 minutes as well as after 1.5, 2, 4, 6, and 8 hours after start of product administration. subjects will also be monitored to capture any adverse events that may occur. the trial is blind in the sense that treatment labels will not be revealed to subjects and trial personnel. also the bioanalysts, pharmacokineticists and monitor will be unaware of treatment labels.

Eligibility criteria:
inclusion criteria: * healthy subjects, smoking at least 15 cigarettes daily during at least one year preceding inclusion and bmi between 17.5 and 30.0 kg/m2 and a total body weight of at least 55.0 kg. * female participants of child-bearing potential are required to use a medically acceptable means of birth control. * a personally signed and dated informed consent document, indicating that the subject has been informed of all pertinent aspects of the study. exclusion criteria: * pregnancy, lactation or intended pregnancy. * treatment with an investigational product or donation or loss of blood within 3 month preceding the first dose of study medication.

Keywords: smoking cessation, nicotine pharmacokinetics
evaluation of right ventricular function post mitral valve operations

Conditions: Right Ventricular Dysfunction

Summary: we aim to determine the function of right ventricle post mitral valve surgeries in patients with pulmonary hypertension using transthoracic echocardiography3- and 6-months post-operatively to detect the effect of mitral valve surgeries over the rv function whether improving, deteriorating, or not changing at all.


Eligibility criteria:
inclusion criteria: * patients who underwent mitral valve surgeries who also had pulmonary hypertension in the period between march 2019 and march 2022 in assiut university heart hospital exclusion criteria: * patients who underwent mitral valve surgeries with normal pulmonary pressure. patients who had other valve surgeries besides mitral as aortic and/or tricuspid valve surgeries. patients had mitral valve surgeries with other heart conditions that needed another intervention in the same session as cabg for ihd.
a multi-site clinical evaluation of the liaison nes flu a/b, rsv & covid-19 assay in symptomatic patients

Conditions: Influenza a; Influenza B; RSV; COVID 19

Summary: the diasorin molecular liaison® nes flu a/b, rsv \& covid-19 real-time polymerase chain reaction (rt-pcr) assay is intended for use on the diasorin liaison® nes instrument for the in-vitro qualitative detection and differentiation of nucleic acid from influenza a, influenza b, rsv and sars-cov-2 virus from dry nasal swabs (ns) from human patients with signs and symptoms during the acute phase of respiratory tract infection in conjunction with clinical and epidemiological risk factors. the liaison® nes flu a/b, rsv \& covid-19 assay is intended for use as an aid in the differential diagnosis of influenza a, influenza b, rsv and sars-cov-2 infection in a professional laboratory setting. negative results do not preclude influenza a, influenza b, rsv or sars-cov-2, infection and should not be used as the sole basis for patient management decisions. the assay is not intended to detect the presence of the influenza c virus.


Eligibility criteria:
inclusion criteria: * the specimen is a nps or ns from a patient collected and preserved in 3 ml universal transport media (utm), bd universal viral transport (uvt), or microtest m4rt transport media, or 1 ml copan eswab (liquid amies). * the specimen is from a patient who is either hospitalized, admitted to a hospital emergency department, visiting an outpatient clinic or resident of a long-term care facility. * the specimen is from a human patient with active signs and symptoms of respiratory tract infection at time of collection * specimen stored at 2-8°c for up to 72 hours from collection. if there is a delay in testing, store specimen at ≤-70 °c. * the total volume of the leftover specimen received is ≥1.5 ml, except for specimens collected in liquid amies which requires a total leftover volume of ≥0.5 ml * the specimen was received in good condition (no leakage or drying of the specimen). exclusion criteria: * incorrect swab type * incorrect transport media * incorrect specimen handling (e.g. specimens not stored at recommended temperature) * the specimen has undergone more than two freeze/thaw cycles * specimens collected with calcium alginate or organic swabs