Kornimate/medical-research-clean huggingface dataset:
transverse abdominis plane block for anterior approach spine surgery

Conditions: Spine Surgery; Low Back Pain; Spondylolisthesis

Summary: therapeutic, prospective, randomized, double blind, placebo-controlled, in intention to treat, monocentric study to evaluate the analgesic efficacy of a bilateral tap block after spine surgery with 24 hours morphine consumption

alif is a commonly performed procedure for the treatment of degenerative diseases of the lumbar spine or spondylolisthesis. this technique has many advantages attributed to the absence of posterior spinal muscular pain, a more direct visualization of the disk space, lower incidence of neurological injuries... however, patients experienced moderate to high post operative parietal abdominal pain due to this specific anterior approach. the systematic need for opioids administration may cause many complications and delay the post operative recovery time. the tap block has been described as an effective pain control technique after various lower abdominal surgeries, reducing both pain scores and 24 hours opioids consumption. however the analgesic efficacy of this technique on specific parietal abdominal pain experienced after spine surgery by anterior approach is not clear

Eligibility criteria:
inclusion criteria: * patient with age above 18 years old * patients scheduled for spine surgery by anterior approach * patient who signed an informed consent form exclusion criteria: * allergy to ropivacaine * weight \< 50 kg * contra indication to tap block : sepsis in the point of draining, bleeding disorder * contra indication to paracetamol: severe hepatic insufficiency * contra indication to ketoprofen: age ≥ 75 years, renal insufficiency, previous gastric ulcer, allergy * contra indication to nefopam: severe cardiac insufficiency, glaucoma, prostate hypertrophy, allergy * known allergy to active substance or at least to one excipient (propofol, paracetamol, morphine, remifentanil, cisatracurium) * allergy to fentanyl, atracurium, or benzin sulfonic acid derivative, to propacetamol * convulsions or previous convulsive disorder * severe respiratory insufficiency * abnormal hemostasis or anticoagulant treatment because of possible intramuscular injection * morphine intake 24 hours before surgery * chronic use of morphine, gabapentin, pregabalin * pregnancy or breastfeeding * patient unable to use patient controlled analgesia (pca) (old patient depends...) * patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
2019-ncov outbreak and cardiovascular diseases

Conditions: Cardiovascular Death; Major Adverse Cardiovascular Events

Summary: cardiovascular events occurring after 2019-ncov outbreak in jinan were prospectively assessed by emergency physicians. we compared those events with events that occurred during the past 3 months and the same months of the last year.

this survey aims to assess whether the public anxiety from a novel coronavirus (2019-ncov) outbreak increases cardiovascular disease risk in china. cardiovascular events occurring after 2019-ncov outbreak in jinan were prospectively assessed by emergency physicians. we compared those events with events that occurred during the past 3 months and the same months of the last year.

Eligibility criteria:
inclusion criteria: * patients visiting emergency department. exclusion criteria: -
telerehabilitation following acl reconstruction

Conditions: ACL Injury

Summary: telerehabilitation is a form of tele-treatment in which rehabilitation services are dispensed at patients' home utilizing video telecommunication services with real-time synchronous exchange of information. the advantages of telerehabilitation include reducing unnecessary travel to the hospital and person to person contact while maintaining social distancing. while some of the patients are truly staying at remote areas, others are unable to manage travel in the lockdown period. telemedicine offers the opportunity to deliver rehabilitative services in the patients' home, closing geographic, physical, and motivational gaps. punctuality on either side is also assured since the travel times are saved on both the ends. the purpose of the proposed study is to evaluate telerehabilitation vs. in-person rehabilitation following acl reconstruction. objectives include assess return to sport and patient reported functional outcomes.


Eligibility criteria:
inclusion criteria: * scheduled for acl reconstruction * age 18-40 * ability to comply with a standardized postoperative protocol * willing and able to provide consent exclusion criteria: * pregnant patient * age \>40 years, or \< 18 * previous knee surgery * unable to speak english or perform informed consent
psychosocial intervention for older hiv+ adults with hand

Conditions: HIV/AIDS; Aging; Mild Cognitive Impairment; Group, Peer

Summary: ctnpt 029 will test the feasibility and acceptability of cognitive remediation group therapy in older adults living with hiv who have been diagnosed with hiv-associated neurocognitive disorder (hand). the cognitive remediation therapy will include tablet-based cognitive training and mindfulness-based stress reduction sessions.

approximately half of the aging hiv-positive population will be affected by hand, making cognitive impairment related to hiv a significant comorbidity in this population. with the development, access to, and early initiation of modern antiretroviral therapy (art), hand is less severe and less common than it once was. however, people who were treated with old therapies, ones that were less effective and with higher rates of toxicity compared to current regimens, or who experienced aids defining illnesses, may be affected by hand more frequently and more severely. issues with cognition, memory, processing new information, problem solving, and decision making are all potential symptoms. psychosocial interventions have been used to decrease stress and depression and improve coping and quality of life in the general aging population experiencing cognitive impairment and depression. these techniques, which can vary widely, have not been fully tested in people aging with hand. ctnpt 029 (a pilot trial funded by the ctn) seeks to enroll 16 people at st. michael's hospital in toronto. study participants will be randomized to either receive cognitive remediation group therapy (crgt) or standard hiv group therapy (control group). both group therapies consist of a series of weekly 3-hour sessions led by a certified social worker and a peer. the crgt group will spend one hour per session on brain training exercises (positscience software) and the remaining two hours on mindfulness-based stress reduction (meditation, breathing exercises, etc.). the control group will focus on general health and wellbeing for people aging with hiv. study investigators will determine the usefulness of the structure of the sessions and the feasibility and acceptability of performing a study of this kind.

Eligibility criteria:
inclusion criteria: 1. male or female; aged ≥ 40 years 2. documented hand diagnosis of mild neurocognitive disorder (mnd) 3. ≥ 5 years of hiv infection 4. provided consent to st. michael's hospital to be contacted for future research studies 5. can feasibly attend 8 weeks of group therapy in downtown toronto exclusion criteria: 1. documented hand diagnosis of asymptomatic neurocognitive impairment (ani) or hiv-associated dementia (had) 2. hospitalization within past 1 month 3. inability to communicate in english 4. inability to use a tablet 5. anyone deemed by the principal investigator to be disruptive to a support group setting

Keywords: hiv-associated neurocognitive disorder (hand) cognitive remediation group therapy mutual aid group therapy
different anesthetic managements of esophageal resection and reconstruction

Conditions: Anesthesia; Esophagus Cancer; Postoperative Complications

Summary: anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality. this study aims to investigate the effect of goal directed fluid management on the postoperative outcome of esophageal resection and reconstruction.

anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality. excessive fluid administration may result in pulmonary complication, while extremely hypovolemia may lead to shock, circulatory dysfunction, and renal damage. little is known about fluid status will have impact on anastomotic leakage. goal-directed fluid therapy has shown to benefit perioperative outcome in major abdominal surgery. this study aims to investigate the effect of goal directed fluid management on the postoperative outcome of esophageal resection and reconstruction.

Eligibility criteria:
inclusion criteria: * patients diagnosed as esophageal cancer * scheduled for minimally invasive esophageal resection and reconstruction exclusion criteria: * end-stage organ dysfunction, including heart failure, hepatic failure, renal failure * arrhythmia * pregnancy

Keywords: outcome
the effect of serious game on hospitalized children's anxiety, fear, knowledge, and anxiety levels in their parents

Conditions: Serious Game on Hospitalized Children

Summary: children may view hospitalization as a stressful experience. children who are hospitalized show high levels of anxiety symptoms. during the hospitalization process, the family of the child as well as the children experience anxiety and stress. these fears and concerns are based on inadequate preparation for hospitalization and lack of knowledge. interventions to reduce the fear and anxiety of children during hospitalization include classical methods such as developing booklets and drawing pictures. while various benefits of these methods have been demonstrated, computer and web-based interventions have been shown to be the best way to prepare children for hospitalization. when computer and web-based interventions are examined, it is seen that they mostly focus on anxiety and pain control in children who are hospitalized for the operation process. more studies are needed to prepare hospitalized children for clinical procedures, to introduce the hospital environment, and to introduce the tools used in the hospital with computer and web-based interventions. the research is a randomized controlled experimental study consisting of three stages. in the first stage of the research, serious game was developed. in the second stage, a randomized controlled study with experimental control group design was carried out. in the third stage, children's views and perceptions about serious play were determined and the effectiveness of the game was evaluated. the population of the research consisted of children aged 8-12, hospitalized in pamukkale university hospitals pediatrics service between october 2022 and february 2023. the g. power program was used in the sample calculation and the sample size was calculated as 53 (effect size 0.50, power 95%). considering that there may be data loss while collecting the data, it was increased by 20% and the experimental group was determined as 32 and the control group as 32.


Eligibility criteria:
inclusion criteria: * accept to participate in the study * children hospitalized for the first time * inpatient treatment between the ages of 8-12- * comprehension and speech impairment * without any mental disability * children and parents whose hospitalization is planned for at least three days exclusion criteria: * daily and hospitalizations less than three days * repeated hospitalizations * speech, comprehension and mental problems * being treated for an oncological problem * applied for trauma * children and parents who did not agree to participate in the study

Keywords: serious game anxiety fear hospitalized children parent
caregiver wellness after traumatic brain injury (cg-well): an intervention designed to promote well-being in caregivers of acute moderate to severe traumatic brain injuries

Conditions: Trauma, Brain

Summary: after injury, survivors of mstbi depend on informal family caregivers. upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive symptoms. caregivers frequently report minimal support or training to prepare them for their new role. periods of care transitions, such as icu discharge, are most difficult. the majority (93%) of previously developed caregiver and caregiver/survivor dyad interventions after mstbi focus on providing information or practical skills to either survivors, or to long-term caregivers (\>6 months post injury), rather than education, support, and skill-building that the new caregiver may use proactively that will benefit the dyad acutely after injury. the aims of this proposal are to: (1) determine feasibility, satisfaction, and data trends of cg-well; and (2) understand how baseline psychosocial risk factors affect response to cg-well compared to an information, support, and referral control group. to accomplish this, i will first enroll 6-10 caregivers and tailor cg-well until each finds the intervention acceptable, appropriate, and feasible. i will then enroll 100 (50/group) dyads and determine satisfaction ratings, recruitment, retention, and treatment fidelity of cg-well. additionally, i will determine if caregivers report reductions in depressive symptoms and improvements in life changes as a result of improvements in task difficulty and threat appraisal in cg-well compared to isr at six months. information obtained in aims 1 and 2 will be used to plan a larger phase iii trial of cg-well. completing these aims and the training plan will improve outcomes of caregivers and downstream outcomes of survivors of mstbi, and provide me with the skillset necessary to become an independent researcher who can develop and test high-impact, high-fidelity, sustainable interventions.


Eligibility criteria:
inclusion criteria: * survivor and caregiver ≥18 years old * survivor gcs 3-12 after resuscitation * survivor \< 2 weeks post injury * english speaking - survivor and caregiver exclusion criteria: * patient not expected to survive. * pregnant - survivor or caregiver * prisoner - survivor or caregiver * history of pre-existing condition that would interfere with follow-up in caregiver or survivor (e.g., substance abuse, alcoholism, end-stage cancers) * major prior debilitating neurological or mental health disorder in caregiver or survivor (e.g., schizophrenia, bipolar, stroke, dementia).
perioperative antibiotic choices for surgical prophylaxis in penicillin-allergic pediatric patients

Conditions: Penicillin Allergy

Summary: the proposed research project will retrospectively review the anesthetic records over the past 5 years and identify patients who present with a history of penicillin allergy or allergy to an antibiotic in the penicillin family. the reason for that history and the facts on which that allergy are noted will be determined. additionally, the choice of antibiotic prophylaxis will be recorded and any adverse effect to that antibiotic noted. we will also note whether appropriate timing of the antibiotic is achieved.


Eligibility criteria:
inclusion criteria: * patients that are labeled as penicillin or penicillin family allergic. exclusion criteria: * as neurosurgical patients routinely receive vancomycin at nch for surgical prophylaxis, they will be excluded from the study.
long-term iron supplements and malaria risk in early pregnancy: a randomized controlled trial

Conditions: Malaria

Summary: a randomized double-blind controlled trial will be carried out in which young, nulliparous (having never given birth) women will be randomly assigned to receive weekly supplementation with either iron and folic acid or folic acid alone. women will be followed-up weekly up to 18 months. women who become pregnant will be followed-up until delivery. malaria risk in both groups will be compared by assessing the prevalence of peripheral parasitaemia at the first antenatal clinic visit for pregnant women and at the end of the first malaria transmission season for non-pregnant women. the incidence of clinical malaria will be assessed by active and passive case detection throughout the follow-up period.


Eligibility criteria:
inclusion criteria: * female * at least 15 and less than 25 years old at enrolment * never given birth * resident within the demographic surveillance system (dss) area * willing to adhere to the study requirements (including weekly observed drug intake) * provision of written informed consent (if non emancipated minor by guardian/parent with minor's assent exclusion criteria: * no menses for \>3 months and/or palpable uterus or positive pregnancy test if history unclear * concurrent enrolment in another study * intention to move out of the study area for more than 2 months within the next 18 months * any significant illness at the time of screening that requires hospitalization, including clinical signs of severe anaemia (conjunctival or mucosal pallor, tachycardia, respiratory distress) * history or presence of major clinical disease likely to influence pregnancy outcome (sickle cell disease, diabetes mellitus, severe renal or heart disease, open tuberculosis, epilepsy)

Keywords: pregnancy iron deficiency iron supplementation burkina faso
a study to assess the safety, reactogenicity and immunogenicity of a trivalent inactivated poliovirus vaccine (ipv) based on sabin strains compared to conventional salk ipv in a 6, 10 and 14 weeks of age immunization schedule

Conditions: Healthy

Summary: the purpose of this study is to assess the safety and reactogenicity of 3 different dose levels of inactivated poliovirus vaccine based on sabin strains (sipv) in healthy participants, using conventional salk ipv (cipv) as an active control.


Eligibility criteria:
inclusion criteria: * study participant is a boy or a girl, who is eligible for expanded programme on immunization (epi) vaccinations (that is, inactivated poliovirus vaccine \[ipv\], diphtheria, tetanus, whole cell pertussis \[dtwp\]-haemophilus influenzae type b \[hib\]-hepatitis b virus \[hbv\] and 13-valent pneumococcal conjugate vaccine \[pcv13\]) at weeks 6, 10 and 14 and rotavirus vaccination at weeks 6 and 14 * study participant has born after a normal term pregnancy (greater than or equal to \[\>=\]37 weeks) and with a birth weight of \>=2.5 kilogram (kg) * study participant must be healthy as confirmed by the investigator on the basis of physical examination, vital signs and medical history, including the course of the pregnancy and relevant medical history of the mother, such as but not limited to human immunodeficiency virus, hepatitis b virus (hbv), hepatitis c virus status or other significant disease that might impact the participant's health. information about the course of the pregnancy and relevant medical history of the mother is obtained from the mother in person and at the discretion of the investigator without the need for official documentation or testing * each study participant and his or her legally acceptable representative must be willing and able to adhere to the prohibitions and restrictions specified in this protocol * study participant and his or her legally acceptable representative are available and reachable for all scheduled study visits and telephone contacts within the allowed window exclusion criteria: * contraindication to intramuscular (im) injections and blood draws (venipuncture) for example, bleeding disorders * known allergies, hypersensitivity, or intolerance to 1 of the excipients of ipv based on sabin strains (sipv) or conventional salk ipv (cipv) or any other vaccine component in the participant or mother * received polio vaccine or were previously infected with poliovirus * known or suspected autoimmune disease or persistent impairment/alteration of the immune function * known neurological disease including seizures, congenital defects, or genetic disorders (for example, down syndrome)
use of a mobile remote device to optimize pediatric inter-facility transportation: a feasibility study

Conditions: Acute Disease

Summary: this study compares the utilization of remote technology versus not using remote technology when triaging and managing pediatric patients in remote settings prior to pediatric specialized inter-facility transportation.

paediatric specialized inter-facility transport utilizes specialized teams usually made up of a respiratory therapist, paediatric critical care nurse, and paediatric intensivist as medical control. when a nurse practitioner or general practitioner from a remote site has a paediatric acute care referral and wants to arrange transportation there is an initial call at which point there are two priorities: first is obtain a patient history and then provide advice to the remote caregiver to initiate specific therapies; second is to mobilize the specialized team to the patient. the period of time between giving initial advice while dispatching the team and the time when the team arrives, can often be a vulnerable period for the remote caregiver as well as the patient. the ability to directly visualize and assess the patient during this time, as well as assist the specialized team once they arrive may provide improvement in safety and care of the patient. it may also improve triaging and may make the stabilization and departure time more efficient. remote technology will be used for an initial patient assessment after being contacted by phone from the peripheral centre to transfer an acutely ill paediatric patient as assessed by the referral centre care provider. after assessment the patient will be triaged to either remain in the local community, transferred to a regional hospital that provides paediatric acute care (prince albert), or be transported to royal university hospital in saskatoon for tertiary care. data to be collected includes: * duration of time from the beginning of the initial phone call to the first therapeutic intervention * time to stabilization * time to decision for disposition * the duration of contact with the health care provider and the patient * number of scheduled follow-up contacts for a specific patient within 24 hours * number of times the referring centre re-consults * of the patients who triaged to stay in the local community how many were transported to the tertiary care centre within 24hrs * how many patients who arrived at the tertiary care centre were discharged within 24hrs * how many patients on arrival were deemed to be unnecessary the nurses and physicians who are communicating with the intensivist about the case will complete a post-encounter survey to evaluate their experience.

Eligibility criteria:
remote technology group inclusion: * patients ≤ 17 years from peripheral centre (pelican narrows clinic and regina general hospital). * acutely ill. * being considered for medical transport. control group inclusion: * patients ≤ 17 years from peripheral centre (stony rapids, wollaston lake and sandy bay). * chosen from a pre-existing saskatchewan paediatric transport database. exclusion criteria: * patients older than age 17.