Kornimate/medical-research-clean huggingface dataset:
a quality improvement approach to the management of chronic lymphocytic leukemia

Conditions: Chronic Lymphocytic Leukemia

Summary: this project addresses the need to improve physician knowledge and clinical practice patterns related to quality of life (qol) concerns for patients with chronic lymphocytic leukemia (cll).

this multifaceted initiative will include evaluating patient perspectives on their qol, evaluating provider perspectives on managing qol, and providing education to the whole cll care team (hematologists/oncologists, nurse practitioners, physician assistants, and nurses) on contemporary approaches for individualized, patient-centered management of cll. providers, including physicians, nurse practitioners, and physician assistants will participate in educational initiatives geared towards enhancing their knowledge and confidence with managing qol concerns for patients with cll. pre and post surveys will be conducted with providers to evaluate change in these areas. the project aims to train this team on how to enhance communication with patients and caregivers as a means to increase patient engagement in care and qol in this population.

Eligibility criteria:
inclusion criteria: clinician * participant must be a hematologist, oncologist, nurse practitioner, or physician assistant who practices medicine in the duke cancer network * participant treats patients with cll * participant is willing to participate in the educational component of this project inclusion criteria: patient * patient has a diagnosis of chronic lymphocytic leukemia * patient is over the age of 18 * patient is being treated at a duke cancer network affiliate site, * patient is expected to see their physician or another member of their care team at least 3 times annually. * signed informed consent exclusion criteria: clinician * none exclusion criteria: patient * patient is non-english speaking * patient diagnosed with cll \< 60 days ago
effect of ınhaler use on oral health in copd patients

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the aim of this study was to evaluate the effect of oral health education given to individuals diagnosed with copd and using inhaled medication.

before the research data are collected, the purpose, content, scope and duration of the research will be explained in one-to-one interviews with the participants. verbal and written informed consent will be obtained from the participants. after the participants gave consent to the study, they will be divided into intervention and control groups by simple random sampling method. participants will be asked to answer the questions in the data collection tools as they see fit and to answer all of the questions. the data collection form will be applied through face-to-face interviews with participants who meet the inclusion criteria. after each completed questionnaire, the researchers will check whether the answers to the survey questions are missing. when unanswered questions are identified, participants will be invited to fill in the missing information. the completion of the questionnaires and training is planned to take an average of 20-25 minutes for each participant. the experimental group will receive training intervention. no education will be given to the control group. after 3 months, an appointment will be made to evaluate oral health

Eligibility criteria:
inclusion criteria: * diagnosed with copd for at least 6 months, * outpatient and inpatient, * consent to participate in the research, * not under the age of eighteen, * with a metered dose inhaler (mdi) in treatment, * no communication barriers, * no copd exacerbation and/or respiratory tract infection, * according to the gold report; mild (stage 1), moderate (stage 2), severe (stage 3). exclusion criteria: * diagnosed with copd for less than 6 months, * refused to participate in the research, * treatment without metered dose inhalers (mdis), * uncommunicative, * those who withdrew from participating in the study during data collection, * not completing the survey, * copd exacerbation and/or respiratory tract infection,
prognostic value of capillary lactatemia in potentially severe polytrauma patients

Conditions: Polytrauma

Summary: nowadays, the tools available to assess the severity of a polytrauma patient in the pre-hospital setting (vital parameters, shock index, mgap score, vittel criteria) have their limitations and are sometimes subjective. to date, there are no objective, practical and reproducible tools for triaging these patients. venous lactataemia also appears to be predictive of poor outcome in severe trauma. however, there are no studies in the literature on capillary lactataemia, which would indicate the potential severity of a polytrauma patient in the pre-hospital setting. however, it is an easily performed, risk-free assay, the results of which can be obtained rapidly at the scene of the accident. the aim of this project is to confirm that, like venous lactataemia, capillary lactataemia can be useful in the pre-hospital phase for predicting a patient's poor outcome. incorporating this assay into the assessment of potentially severe polytrauma patients in the pre-hospital phase could improve the predictive value of clinical and contextual data and thus enable better referral and management of these patients.


Eligibility criteria:
inclusion criteria: * patient over 18 years of age * presenting a potentially serious pre-hospital trauma defined by: o a road accident or a fall of more than 2 metres * requiring the dispatch of a smur 06 team (mobile emergency and resuscitation service) * and transferred to an emergency facility in the alpes maritimes with medical assistance. * consent signed (by the patient or a relative) after the event if it is not possible to sign immediately. * pregnant women may also take part in the study without any risk to themselves or their child. exclusion criteria: * patients with isolated peripheral limb trauma (wrist, elbow, knee, ankle, shoulder) * patients under legal protection (guardianship, curatorship) * patients in cardiorespiratory arrest when taken into care by the smur (emergency medical services)
first report, five years experience of the acute leukemia work group

Conditions: Acute Leukemia (Category)

Summary: the purpose of this study is to describe the incidence, clinic characteristics, biological and suvirval in lymphoblastic leukemia patients in mexico city reference hospitals.

multicenter and retrospective revision of clinical files with acute lymphoblastic leukemia diagnostic between 2009 and 2013 in mexico city reference hospitals, in five hospitals with 50 and 100 new cases acute lymphoblastic leukemia per year. with a expected sample between 500 and 1000 patients it will descriptive statistics of variables. the data collection with necessary variables for survival analysis study and risk factors with kaplan-meier curve and risk proportional method cox.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute lymphoblastic leukemia exclusion criteria none
choroidal thickness measurements during central serous chorioretinopathy (cscr) treatment

Conditions: Choroidal Thickness

Summary: the purpose of this study is to determine changes in choroidal thickness in patients with central serous chorioretinopathy (cscr) during the first 3 months after initial diagnosis via enhanced-depth-imaging-spectral-domain-optical-coherence-tomography (edi-oct). study hypothesis: since exudative changes in the choroid seem to constitute the primary pathology of cscr, changes in choroidal thickness compared to healthy eyes should be present and be visible using edi-oct.


Eligibility criteria:
inclusion criteria: * patients with initial diagnosis of cscr and no treatment so far exclusion criteria: * therapy (drugs/laser) due to cscr
open registry measuring impact of genomic testing on treatment of prostate cancer patients

Conditions: Prostate Cancer

Summary: this registry is intended to evaluate the impact of genomic test results towards selecting a first-line therapy option for newly diagnosed localized prostate cancer patients.


Eligibility criteria:
inclusion criteria: * newly diagnosed (≤6 months), untreated patients with histologically proven adenocarcinoma of the prostate that have the following characteristics. * clinically localized (no evidence on clinical or imaging studies of advanced disease). * no hormonal therapy including lhrh (luteinizing hormone-releasing hormone) agonist or antagonist, anti-androgen, estrogens or exogenous androgens, when applicable. * sufficient amount of tissue remains from biopsy to perform genomic testing. exclusion criteria: * patients with a known history of hypogonadism
open label phase iii duloxetine study for stress urinary incontinence

Conditions: Urinary Incontinence Stress

Summary: the purpose of this study is to monitor the long term safety of duloxetine in the treatment of stress urinary incontinence.


Eligibility criteria:
inclusion criteria: * female out patients * are ambulatory and are able to use a toilet independently and without difficulty. exclusion criteria: * use of monoamine oxidase inhibitors (maois)
evaluation of blood-retinal barrier functional alterations by optical coherence tomography

Conditions: Diabetic Retinopathy

Summary: the purpose of this study is to identify alterations of the blood-retinal barrier (brb) in diabetic retinas using a novel non-invasive approach based on the fourier domain high-definition optical coherence tomograph (oct).

type 2 diabetic patients with nonproliferative diabetic retinopathy (npdr) (study population) and healthy volunteers (control population). inclusion criteria: age over 18 years; type-2 diabetes; npdr levels 10, 20 and 35/47 (etdrs severity scale); and an area of retinal leakage of at least 25% of the rla map (macular area). exclusion criteria: presence of media opacity; vitreous syneresis or posterior vitreous detachment, and; previous photocoagulation treatments or any type of intraocular surgery or intravitreal medications; and other retinal pathologies.

Eligibility criteria:
inclusion criteria: * age over 18 years; type-2 diabetes; npdr levels 10, 20 and 35/47 (etdrs severity scale), and area of retinal leakage of at least 25% of the rla map (macular area). exclusion criteria: * presence of media opacity; vitreous syneresis or posterior vitreous detachment, and; previous photocoagulation treatments or any type of intraocular surgery or intravitreal medications.
pressure intensity of a chinese massage technique for treating low back pain

Conditions: Low Back Pain, Mechanical

Summary: the investigators conduct this study to compare two different massage methods with "buffalo horn technique": the deep massage and the superficial massage. to explore the effects of the two interventions on low back pain, the investigators evaluated the outcome measurements regarding pain severity and physical functions before and after 6 times of treatment through a 3-week period.

background: nonspecific lower back pain is an important global health issue, with high prevalence over the world and causing huge economic loss. this research is a double-blind randomized controlled trial. in this study the investigators introduce a technique derived from traditional chinese massage using a special tool made from buffalo's horns to perform the massage, so called "buffalo horn technique". the tool is like a short rod in about 15-cm length with a cone-like end. during the massage, the therapist presses the cone-like end against the painful region of back. because the cone-like end has a small contact area with the participant's body surface, it may release deep layer fascia with higher pressure produced by the therapist toward the treatment area. during the intervention of shallow massage, the therapist applies a lower force then that used in the deep massage. thus it produces a lower pressure on the painful region due to a larger contact surface when pressing the rod end against the body of the participant. participants are randomly assigned to either deep-massage group (dm) or superficial-massage (sm) group. the participants received two sessions a week for a total six sessions. the outcome measures include the structured questionnaire to investigate the pain-related outcomes and back pain-related disabilities. the investigators also perform the clinical assessments such as range of motion of trunk. all the outcomes are assessed before-intervention (pretest) and after the end of intervention (posttest).

Eligibility criteria:
inclusion criteria: 1. female 2. non-specific low back pain over 1 months 3. 20-65 years old 4. no experience of massage therapy within 2 months prior to the study inclusion. exclusion criteria: 1. pregnancy 2. back pain associated with systemic disease (autoimmune, infectious, vascular, endocrine, metabolic, or neoplastic disease) 3. previous spine surgery. 4. presentation with neurological signs such as radiating pain. 5. .skin diseases (psoriasis, urticaria, wounds, etc.)

Keywords: alternative therapy massage manual therapy myofascial
topiramate and severe obesity

Conditions: Obese Children and Adolescents

Summary: the purpose of this study is to evaluate the efficacy of topiramate on the decrease of body mass index compared to placebo at 9 months.

childhood obesity remains through adulthood in main cases, and is associated with an early increase of cardiovascular risk and an excess mortality in young adults due to stroke and cancer. bariatric surgery is very rare in france for children and can cause severe complications. long term effects are still unknown. topiramate is already use in thousands of children in neurology, its effects are already well known, and no lethal complication is reported. the hypothesis is that topiramate associated with standard treatment of obesity is more effective than standard treatment alone. this will be a 4.5-years, randomized, double-blind, placebo-controlled, clinical trial of topiramate (9 months) vs placebo (9months) for body mass index reduction in 160 adolescents (ages 9-17 years old) with severe obesity. the main objective is to evaluate the efficacy of topiramate on the decrease of body mass index compared to placebo at 9 months. the secondary objectives are to evaluate: * the decrease of body mass index z-score * the tolerance of topiramate * the effectiveness of topiramate on weight decrease and decrease of body mass index and body mass index z-score at 1, 3 ,4 and 6 months * the effectiveness of topiramate on eating behaviour, physical activity, calculated with validated questionnaires and scales at 6 and 9 months * the pharmacokinetic of topiramate in obese children and adolescents

Eligibility criteria:
inclusion criteria: * 9-17 years old * body mass index z-score ≥ 4 sd of french reference * weight at enrolment ≥ 50 kg * therapeutic failure \> 6 months * for girls of childbearing age, willing to have an acceptable method of contraception (no estrogens plus progestin) * negative pregnancy test for girls of childbearing age * agreeing to participate upon written informed consent * appropriate understanding of the study exclusion criteria: * syndromic or secondary obesity * major neurological or psychiatric disorder * current or history of suicidal thought/attempts * current or history of breakdown * previous bariatric surgery * severe hypercapnia * renal dysfunction * deformity in the urinary tract or solitary kidney * history of renal lithiasis or glaucoma * poorly controlled diabetic children or adolescents (hba1c \>10%) and diabetic patients treated with metformine and/or glibenclamide * hepatic dysfunction * bicarbonate ≤16 mmol/l * known hypersensitivity to the active substance or to one of the excipients * intolerance to saccharose * enrolment in another therapeutic study * high probability to fail to comply with treatment * females: pregnant, planning to become pregnant * no signature on consent form * uncovered by the french national health insurance system (sécurité sociale)

Keywords: topiramate obesity children adolescents
effects of thrower's ten and routine physical therapy in patients with shoulder impingement syndrome

Conditions: Shoulder Impingement Syndrome

Summary: to compare the effects of thrower's ten and routine physical therapy on pain, range of motion and functional disability in patients with shoulder impingement syndrome

shoulder impingement is a common cause of shoulder pain. it's also known as impingement syndrome or swimmer's shoulder, since it's common in swimmers. it occurs when there is impingement of tendons or bursa in the shoulder from bones of the shoulder. a randomized clinical trial will be conducted at ibne sina hospital,multan . non probability convenience sampling technique will be applied on 46 patients who will be allocated through computerized randomization into group a \& group b to collect data. group a will be given throwers ten program and group b will be given routine physical therapy along with baselines. the study will be completed within the time duration of nine months. primary outcome measures of the research will be pain, range of motion,function and disability . data will be analyzed using spss software version 25. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * age group 18-35 years * male and female * shoulder or neck pain within the prior 6month * 3 positive tests out of 5: positive neer's test, positive hawkins test, positive jobe's test, painful arc, and pain on resisted external rotation of the arm. exclusion criteria: * history of surgery of the affected shoulder * fractures in around the shoulder * neurological disorders leading to altered muscle activity * systemic arthritic conditions (ra, osteoporosis) * disorders of the cervical spine
study of utilization patterns of dimethyl fumarate in germany

Conditions: Multiple Sclerosis

Summary: the primary objective of this study is to estimate the proportion of dmf use that is prescribed "on-label" versus "off-label". the secondary objectives are: to describe the demographic characteristics and medical history of dmf users; to describe prescription drug history and concomitant medication use of dmf users; to describe the duration of therapy in participants newly initiating dmf treatment; to describe the medical specialties of dmf prescribers.

dimethyl fumarate will not be provided to participants as a part of this study.

Eligibility criteria:
key inclusion criteria: * new users of dimethyl fumarate will be included in the analysis key exclusion criteria: * patients for which data is not available for the 6 months period prior to the index date (baseline observational period) note: other protocol defined inclusion/ exclusion criteria may apply.

Keywords: tecfidera off-label utilization
anticoagulant therapy and 28-days mortality in critically ill covid-19 patients

Conditions: Covid-19; Thromboembolic Events; Bleeding

Summary: the aims of the study are to to associate anticoagulation (ac) regime with outcome in critically ill patients with covid-19. this will be done by describe baseline characteristics and comorbidities before hospital admission, level of organ support and dose of ac treatment and associate this with 28 days survival, survival outside icu, thromboembolic event and bleeding complications.


Eligibility criteria:
inclusion criteria: * laboratory confirmed positive test for sars-cov-2 * admitted to icu because of critical illness due to covid-19 exclusion criteria: * patients with treatment for thromboembolic complications at arrival to the icu * short icu length of stay defined as discharged the same or the following day as icu admission
trial of a video game intervention to recalibrate physician heuristics: a followup study

Conditions: Wounds and Injuries

Summary: the objective of this study is to measure the duration of two different types of interventions to change physician decision making in trauma triage: a video game and an educational program.

treatment at trauma centers improves outcomes for patients with moderate-to-severe injuries. accordingly, professional organizations, state authorities, and the federal government have endorsed the systematic triage and transfer of these patients to trauma centers either directly from the field or after evaluation at a non-trauma center. nonetheless, between 30 to 40% of patients with moderate-to-severe injuries still only receive treatment at non-trauma centers, so-called under-triage. most of this under-triage occurs because of physician decisions (rather than first-responder decisions). existing efforts to change physician decision making focus primarily on knowledge of clinical practice guidelines and attitudes towards the guidelines. these strategies ignores the growing consensus that decision making reflects both knowledge as well as intuitive judgments (heuristics). heuristics, mental short cuts based on pattern recognition, drive the majority of decision making. the investigators developed an adventure video game (night shift) to serve as a novel method of recalibrating physician heuristics in trauma triage and compared its efficacy with a standard educational program. this study is designed to measure the degradation of the treatment effect.

Eligibility criteria:
inclusion criteria: * physicians who care for adult patients in the emergency department. * physicians who work at a non-trauma center. * physicians who work at a level iii/iv trauma center. exclusion criteria: * physicians who work only at a level i/ii trauma center. * physicians who do not practice in the us.

Keywords: decision making heuristics
image-guided tumorboost of bladder cancer

Conditions: Bladder Neoplasms

Summary: the purpose of the study is to increase the radiation dose (boost) to the bladder tumor. the bladder cancer patients included in the study will undergo tumor demarcation. the bladder demarcations will then be the target for an image-guided boost delivered precisely to the expected tumor site.


Eligibility criteria:
inclusion criteria: * muscle invasive bladder cancer (transitional carcinoma) * unifocal * tnm stage t2a-4a, n0-1, m0 * unfit for radical cystectomy exclusion criteria: * hyperthyroidism * multinodular goiter * pregnancy * breast feeding * who preformance status more than 2 * iodine allergy * mri or ct contrast media allergy * bi-lateral hip-prosthesis

Keywords: image-guided radiotherapy fiducial marker adverse effects
randomized controlled trial of subconjunctival bevacizumab injection in impending recurrent pterygium

Conditions: Pterygium of the Conjunctiva and Cornea

Summary: hypothesis: subconjunctival bevacizumab injection may potentially suppress neovascularization in pterygium, preventing or retarding the progression of recurrence.

1. impending recurrent pterygium 2. anti-vegf therapy * bevacizumab * subconjunctival injection * suppress neovascularization

Eligibility criteria:
inclusion criteria: 1. impending recurrent pterygium developed within 6 months following pterygium surgery either simple excision or excision with grafting. 2. failure of conventional topical anti-inflammatory therapy for impending recurrent pterygium which was defined by the progression of fibrovascular tissue over the excised area despite receiving treatment. 3. no history of any adjunctive treatment such as mmc, 5-fu, periocular injection of corticosteroids and beta radiation. 4. no other ocular surface pathologies or coexisting ocular diseases. 5. no other ocular surgeries within the previous 6 months. 6. no history of allergy to the medications used in this study. 7. good compliance with the study regimen and availability for the duration of the entire study period. exclusion criteria: 1. platelet disorders 2. hypertension 3. pregnant or lactating women

Keywords: bevacizumab, impending recurrent pterygium