Kornimate/medical-research-clean huggingface dataset:
transcranial direct current stimulation (tdcs) as a cognitive enhancer for patients with alzheimers disease

Conditions: Alzheimer Disease

Summary: the purpose of this study is to investigate transcranial direct current stimulation (tdcs) as a cognitive enhancer for patients with alzheimer disease. transcranial direct current stimulation (tdcs) is a neuromodulation technique, that are applied to the brain by using two electrodes. these electrodes are placed on the scalp. the current is low intensity, usually 1-2 milliampere. tdcs may affect cognitive functions by increasing cortical excitability. tdcs is regarded as a safe treatment approach. in the present study, participants will undergo six stimulations. the effect of all stimulations swill be measured with neuropsychological testing before the first (pre) and after the sixth tdcs stimulation (post).

the present study is a randomized controlled study (rct) and will use tdcs to stimulate left temporal lobe and hopefully improve verbal memory functions. a total of 30 patients with alzheimer disease will receive tdcs treatment for 30 minutes, six times. half of the patients will undergo sham stimulation. these six stimulations will be executed during 10 days. patients will be tested with neuropsychological tests before the first stimulation and after the last stimulation to assess the effect of the treatment. patients will be retested six months later in order to investigate long-term effects ot the stimulation. the main hypothesis in the present study is that tdcs stimulation will lead to significant improvements in verbal memory functions.

Eligibility criteria:
inclusion criteria: * alzheimers disease according to (national institute of neurological and communicative disorders and stroke and the alzheimer's disease and related disorders association). * the cognitive impairment and decline must be documented by cognitive / neuropsychological testing and from an informant. exclusion criteria: * stroke, * cancer, * psychiatric disorders (major depression, psychosis) or diseases / injuries in the central nervous system.

Keywords: alzheimers disease transcranial direct current stimulation (tdcs) neuromodulation neuropsychology
progression of atrial fibrillation in the young

Conditions: Atrial Fibrillation

Summary: the purpose of this study is to investigate the presence and magnitude of structural changes of the heart and their long-term development in young patients with atrial fibrillation (af), studied by echocardiographic measurements and plasma biomarkers and their association to af burden, studied using long-term ecg

100 patients with symptomatic atrial fibrillation diagnosis are included. diagnosis is set either at the index visit or within 12 months before inclusion. . the follow up period is 5 years. patients presenting with af in connection with acute infection, acute cardiac ischemia, surgery or thyroid disease are excluded. further, af patients with cardiomyopathies, known genetic diseases and congenital cardiac abnormalities are also excluded. at inclusion patients undergo an in-depth interview regarding comorbidities, medication, previous treatments related to the af diagnosis. in addition, baseline data for weight and height are collected. in connection to inclusion the patients are asked leave venous bloodwork (na, k, creatinine, plasma glucose and ntprob-type natriuretic peptide). an echocardiographic exam is performed according to a prespecified protocol with special emphasis on the left atrial function and anatomy. this is followed by a continuous ecg recording for 14 days using biotel epatch. the ecg patch is later returned to a core facility by mail. the patients´ are followed for five years and are asked to leave bloodwork and perform a 14-day ecg recording yearly. after these exams, a follow up phone call is placed to the patient aimed at documenting clinical progress related to symptoms, treatment and interventions. after 5 years follow up patients undergo a follow up echocardiographic exam in addition to yearly bloodwork and ecg recording. the patients´ clinical symptoms are treated at the clinician´s discretion according to current guidelines.

Eligibility criteria:
inclusion criteria: * atrial fibrillation * diagnosis of atrial fibrillation within one year of inclusion exclusion criteria: * duration of atrial fibrillation over one year. * acute stressor for atrial fibrillation such as: acute ischemic heart disease or infection

Keywords: atrial fibrillation progression left atrial function
continuous glucose monitoring in prediabetes with health education videos

Conditions: Prediabetes

Summary: the objective of this project is to deliver a behavior health education video series that combines wearable continuous glucose monitoring (cgm) with smartphone feedback and video clips generated by artificial intelligence (ai) software to improve glycemic control among individuals with prediabetes. the goal is to prevent transition to type 2 diabetes and advanced metabolic complications.

a health education video series, ¡mi control!, led by community health workers known as promotores de salud (pds), will be integrated with continuous glucose monitoring (cgm) to support self-monitoring of glucose levels and excursions. study g2 is a phase 0 feasibility study enrolling 30 spanish- and/or english-speaking pds who test positive for prediabetes via a finger-prick a1c% screening. participants will wear cgm devices for 20 days, with glucose data masked for the first 10 days and unmasked for the next 10 days. during the unmasked phase, participants will receive daily health education videos on their smartphones. the study will compare the duration of glucose excursions between the masked and unmasked phases to assess the impact of cgm feedback and health education on glucose regulation.

Eligibility criteria:
inclusion criteria: pre-diabetes determined by finger prick a1c% willingness to wear a cgm sensor community health worker exclusion criteria: currently pregnant diagnosed with any disorder likely interfering with blood glucose levels influential medical disorder or event affecting ability to participate in the study incompatible smartphone device not pairing with the dexcom cgm system

Keywords: prediabetes glucose control feedback health education artificial intelligence behavioral analysis
multiple disseminated hydatidosis with rare locations

Conditions: Echinococcus Infections

Summary: hydatid disease is an anthropozoonosis due to the development of the larval form of echinococcus granulosus in the human body, which constitutes a 'dead-end' host. it's a common parasitosis in north african countries and constitutes a public health problem in morocco. the liver and lung are the most affected while the mediastinum, pancreas and pelvis are rarely affected. we report the case of a 40-year-old patient operated 15 years ago for cerebral and cervical hydatid cysts and who was hospitalized for generalized mucocutaneous jaundice. on exploration, we discover the presence of disseminated abdominal hydatidosis with association of 3 rare locations: mediastinal, pancreatic and pelvic. indirect diagnostic tests were positive: indirect hemagglutination (iha) and elisa. the western blot test also showed the presence of specific bands, thus making it possible to retain the diagnosis of hydatidosis. the hydatid cyst with mediastinal, pancreatic and pelvic location is rare and their association is very exceptional. it is essential to evoke the hydatid origin of any cystic lesion in a patient staying in an endemic area.


Eligibility criteria:
inclusion criteria: * none exclusion criteria: * none

Keywords: echinococcus serology multiple locations
risk factors for anxiety and depression among pregnant women during the covid-19 pandemic

Conditions: Anxiety; Depression; Pregnancy Related

Summary: the article presents a protocol of a cross-sectional study of mental health of pregnant women in relation to the covid 19 pandemic. the primary aim is to compare differences in anxiety and depression scores of pregnant women between countries affected by the covid-19 pandemic. the secondary aim is to assess demographic, economic, and social aspects affecting maternal anxiety and depression scores among pregnant women worldwide in the time of the covid-19 pandemic. finally, investigators will be able to compare differences in perception of the different aspects of the covid-19 pandemic (social distancing, restrictions related to delivery) between countries and according to the epidemic status (number of infected patients, number of reported deaths). the comparisons will also be done according to covid-19 status of the participants.


Eligibility criteria:
inclusion criteria: * declaration of being pregnant * being able to complete the survey in the available languages * answer the screening questions * provide informed consent for participation exclusion criteria: * not providing online informed consent for participation * if the participant does not click on the submit button at the end of the survey * not answer all the gad-7 and phq-9 scale questions

Keywords: coronavirus mental health pregnancy anxiety depression covid-19 pandemic
clinical investigation of the multi4 system

Conditions: Bladder Cancer

Summary: a clinical investigation to confirm performance and safety of the multi4 system in patients with suspected recurrent bladder cancer lesions

the overall purpose of this study is to confirm performance and safety of multi4 medical device system when used as intended: to cauterize, remove, and automatically collect multiple tissue samples through the working channel of an endoscope. the safety profile will be documented by collecting data on frequency and severity of complications, aes such as bleeding and perforations.

Eligibility criteria:
inclusion criteria: * previous bladder cancer ta/t1 g1-3 * recurrence of urinary superficial/ non-muscle-invasive bladder cancer visible at cystoscopy, estimated size \< 10 mm * willingness and ability to provide informed consent * age ≥18 years exclusion criteria: * implantable cardioverter defibrillator (icd) that cannot be inactivated * current/ongoing untreated urinary tract infection * pregnancy or breastfeeding * be identified by the investigator as inappropriate from a medical or compliance perspective to participate in this investigation
clinical utility of intraoperative parathyroid scores system in thyroidectomy

Conditions: Intraoperative Parathyroid Scores System

Summary: ready to establish the intraoperative parathyroid scores system (ipss) for thyroidectomy and study the clinical value of intraoperative parathyroid scores system for thyroidectomy.

ipss includes transplantation parathyroid scores and in situ parathyroid scores, the investigators will establish the intraoperative parathyroid scores system by parathyroid size and blood supply, and recording ipss, according to certain rules. parathyroid hormone and calcium were test in d0, d1, d14, d60 post operation. the correlation between intraoperative parathyroid scores and pth calcium were calculated, and roc curve and logistic regression were tested for the prediction value.

Eligibility criteria:
inclusion criteria: 1. postoperative pathology confirmed as thyroid papillary carcinoma; 2. for the first time to undergo thyroid surgery, no history of neck surgery and external radiotherapy; 3. preoperative serum calcium, parathyroid hormone levels were normal; 4. intraoperative and postoperative clinical data integrity, standardized follow-up patients; 5. parathyroid is a tumor violation. exclusion criteria: 1. serious underlying disease; 2. age greater than 60 years of age or combined with arteriosclerotic disease; 3. patients with postoperative loss; 4. patients with parathyroid disease.

Keywords: intraoperative parathyroid scores system total thyroidectomy thyroid cancer hypoparathyroidism prediction
efficacy of targeted abdominal perfusion pressure in septic shock

Conditions: Septic Shock; Septicemia; Intraabdominal Hypertension; Renal Injury

Summary: septic shock is a clinical condition that is defined as a subset of sepsis that causes very high mortality and morbidity. surviving sepsis campaign guideline states that the target mean arterial pressure should be 65 mmhg and above in septic shock patients. it is known that abdominal pressure increases and perfusion of intra-abdominal organs decreases in septic shock patients. with this study, we aim to investigate the effects of targeted abdominal perfusion pressure (60 mmhg and above) on renal injury, reversal of renal injury, liver functions and ultimately mortality in patients with septic shock.

patients diagnosed with septic shock according to "surviving sepsis campaign guidelines 2021" will be included in the study. groups will be formed after the measurement of intra-abdominal pressure (iap). those with iap of less than 8 mmhg will be assigned to the control group and treated according to mean arterial pressure. those with iap greater than 8 mmhg will be divided into two groups by computer-generated randomization (via randomizer.org). one group (group map) will be treated according to mean arterial pressure and the other group (group app) will be treated according to abdominal perfusion pressure. in group app, maximum arterial pressure will be targeted as 130/85 mmhg. all patients will receive appropriate antibiotic therapy, fluid therapy and, vasopressor treatment as recommended in "surviving sepsis campaign guidelines 2021" and abdominal pressure measurement will be repeated every 12 hours. age, sex, body mass index, cause of sepsis and comorbidities of all patients will be recorded. patients will be followed for liver and kidney function tests, procalcitonin and lactate levels, daily sofa (sequential organ failure assessment) calculations, length of stay (days), length of stay in mechanical ventilator (days), and 30 and 90 days mortality.

Eligibility criteria:
inclusion criteria: * diagnosis of septicemia according to "surviving sepsis campaign guidelines 2021" * age lower than 18 exclusion criteria: * reason of admission: cardiac arrest * pregnancy * abdominal surgery in the past 90 days * pre-diagnosis of end-stage renal disease * history of abdominal trauma * body mass index of 30 and above * trauma, bleeding or cerebrovascular event that causes increased intracranial pressure
the effects of 12-week custom-made orthotic intervention on the structure and function of the foot of healthy young adults during gait termination

Conditions: Flatfoot

Summary: the purpose of this study is to explore the long-term effects that orthotics imposes on the structure and function of the foot. the objectives of the study are to determine if the use of custom-made foot orthotics (cfo) cause: (a) changes to the structure of the plantar intrinsic muscles, (b) changes in the rate of muscle activity and timing in the plantar intrinsic muscles and (c) creates any changes in balance control during gait termination. the aim of the study is to enhance the appropriate dispensing of orthotics, and whether additional measures, such as rehabilitation exercises are necessary to increase their overall effectiveness in the clinical setting.

between 20-30 healthy young adults of both males and females will be recruited. a screening questionnaire will be administered to ensure that participants are appropriate for the study. once the participant has met the criteria of the study, the participants will be randomly allocated into one of two groups: (a) the control group or (b) the intervention group. individuals that are selected to be in the intervention group, will be fitted with custom-made orthotics by an experienced pedorthist. the pedorthist will cast the foot posture using a foam impression to custom the design of the foot orthotic. the participant will have a week to acclimatize to the new environment, and if any discomfort arises the pedorthist will make any necessary corrections and the participant will have another week to acclimatize to the orthotic. the control group will not receive an intervention and ask to go about their daily life activities. all participants will undergo the same testing procedures at 6 and 12 weeks after baseline testing. at baseline, 6 weeks and 12 weeks post-baseline, the researcher will take a diagnostic ultrasound image of the foot muscles prior to the gait trials. the researcher will also place 12 infrared markers and surface electrodes on the participant. all trials will be performed barefoot. the participants will then undergo a gait termination protocol. participants will walk down an 8m walk-way with three force plates are embedded into the ground. participants will be asked to walk to the end of the platform until instructed to stop. for 20% of the gait trials, the participants are walking forward until they hear an audio buzzer sound that will signal them to terminate their gait suddenly in the next two steps. all trials will be randomized.

Eligibility criteria:
inclusion criteria: * a score of (+5) on the foot posture index (fpi) * navicular height \< 3.6cm * able to walk exclusion criteria: * have worn cfos in the past year, * current lower limb injury, leg or foot pain * neurological or musculoskeletal disorders affecting the function of the foot * previous history of lower limb surgery * protein intake above the recommended daily allowance (rda) * medications that effect balance.

Keywords: gait balance control orthotics
does the therapist's assessment of movement control in low back pain patients correspond to an objective kinematic modification

Conditions: Chronic Low-back Pain

Summary: * exercise-based treatment is part of the recommendations for good practice in the treatment of low back pain (acute, sub-acute and chronic). * the low back pain population is heterogeneous. this heterogeneity would cause the positive effects of a treatment to be canceled out by the negative effects of another part of the population. * this polymorphism has led several authors to classify low back pain into subgroups. these subgroups constitute more homogeneous clinical pictures and would facilitate the adaptation of treatments. * the recommendations of the american physical therapy association suggest 5 subgroups of low back pain. one of them is "low back pain with movement coordination defect". in this subgroup, luomajoki studied the reliability of different functional tests used in clinical practice. 6 out of 10 motion control fault tests show good reliability. * the quantified analysis of the movement of low back pain patients would make it possible to determine the sensitivity of detecting an anomaly in the 6 lumbar movement control tests.

* exercise-based treatment is part of the recommendations for good practice in the treatment of low back pain (acute, sub-acute and chronic). * the low back pain population is heterogeneous. this heterogeneity would cause the positive effects of a treatment to be canceled out by the negative effects of another part of the population. * this polymorphism has led several authors to classify low back pain into subgroups. these subgroups constitute more homogeneous clinical pictures and would facilitate the adaptation of treatments. * the recommendations of the american physical therapy association suggest 5 subgroups of low back pain. one of them is "low back pain with movement control impairment". in this subgroup, luomajoki studied the reliability of different functional tests used in clinical practice. 6 out of 10 motion control fault tests show good reliability. * the quantified analysis of the movement of low back pain patients would make it possible to determine the sensitivity of detecting an anomaly in the 6 lumbar movement control tests. lobacom is a monocentric, exploratory prospective study. the purpose is to define a kinematic (angular) threshold corresponding to an anomaly detected clinically by three therapists for each test.

Eligibility criteria:
inclusion criteria: * aged more than 18 years * common low back pain with medical prescription for rehabilitation * signed consent * be affiliated to a social security scheme * be able to perform the lumbar motion control failure tests exclusion criteria: * body mass index greater than 30 (obesity) * person who does not understand french * pregnant woman * refusal to participate * volunteer under guardianship or curatorship

Keywords: low back pain movement control kinematic analysis clinical assessment
study of staphylococcus aureus colonization of the posterior nasal cavity in patients undergoing otorhinolaryngologic surgery

Conditions: Staphylococcal Infections

Summary: staphylococcus aureus nasal carriage is a major risk factor of infection with this bacterium. staphylococcus aureus colonization of the posterior nasal cavity is still misunderstood. this study is aimed at evaluating the relationship between staphylococcus aureus strains colonizing the vestibulum nasi, the sphenoethmoidal recess and the nasopharynx.


Eligibility criteria:
inclusion criteria: * patients undergoing otorhinolaryngologic surgery, unknown staphylococcus aureus carriage state * patient affiliated to french social security * written consent exclusion criteria: * antibiotherapy or infectious episode during the month prior enrollment * coagulation disorder * neoplasia of the nasal cavity

Keywords: staphylococcal infections nasal carriage nasal cavity staphylococcus aureus
clinical trial study about human adipose-derived stem cells in the stroke

Conditions: Stroke

Summary: the objective of the study is to confirm the safety and possible efficacy of adipose-tissue derived stem cells treatment of chronic stroke. specifically, the study will transplant autologous adscs into brain surrounding ischemic infarct in adult (65-80 years old) subjects who have chronic non-hemorrhagic stroke (\>6 months).

this open-label clinical trial will compare outcomes of subjects with chronic stroke. six subjects will be to treatment (n=3) groups. the treatment group will receive brain transplants of autologous adscs. treatment group will receive rehabilitation after the transplantation. subjects will be assessed by magnetic resonance imaging (mri) and eight standardized stroke indices: national institutes of health stroke scale (nihss), ( barthel index )、 ( berg balance scale )、 (fugl - meyer test )、(action research arm test )、 (purdue pegboard )、 ( grip strength measurement ) 、(somatosensory evoked potential, ssep) at 1 month, 3 months, and 6 months after treatment.

Eligibility criteria:
inclusion criteria: * stroke investigators with age 65 to 80 years * history of stroke between six months and 10 years * systolic pressure and diastolic pressure were maintained under 160 mmhg and 110 mmhg * inr \< 2.5, platelets counts 1-5 x 10\^5/μl * damaged area range between 0.5 cm to 6 cm by brain mri exclusion criteria: * pregnant women * investigators with aids, cancer, liver dysfunction * others can't fit into the trial evaluate by investigator