Kornimate/medical-research-clean huggingface dataset:
the effect of transcranial direct current stimulation on visual attention in mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: progressively causes the breakdown of cognitive functions and impairs quality of life for patients and their caregivers. in addition to memory impairment, visual attention is also compromised, even at the stage of mild cognitive impairment due to ad (mci-ad). no treatment has been found for mci-ad; therefore, attention has been drawn to non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tdcs), in order to enhance cognitive functions by modifying brain plasticity. in the current research, investigator aim to examine the long-term effects of the optimal multiple-session tdcs protocol in mci-ad on visual attention including the transfer to an ecologically valid virtual environment and identify the neural underpinnings of tdcs-induced behavioral aftereffects using a combined tdcs/ mri network-based approach.

investigator will investigate the long-term effects of 10 active tdcs consecutive sessions using an optimized stimulation protocol as compared to a placebo stimulation on visual attention in the mci-ad. a two-parallel-group, randomized, placebo-controlled design will be used. in addition, the cognitive transfer of tdcs will be evaluated. repeated tdcs sessions will be performed in 10 consecutive sessions (2 weeks: monday to friday) over one preselected roi together with ongoing visual attention training. during the stimulation, investigator will use the visual matching task. before the repeated stimulation sessions, participants will undergo the neurocognitive examination. behavioral examinations of the trained and untrained tasks (i.e. the transfer tasks) will be performed to assess the baseline performance. mri protocol consisting of t1, t2, flair, and fmri during the task performance (visual matching task), resting state fmri, and dti sequences will be acquired before and after the whole 10-day stimulation protocol in order to search for active vs. placebo tdcs-induced changes in brain activation and resting state functional and structural connectivity and to identify neural correlates of behavioral changes. behavioral assessment of the trained task and the transfer task will be repeated immediately after and again at a one-month follow-up visit after the end of the last stimulation session

Eligibility criteria:
inclusion criteria: * amnestic single or multi-domain mild cognitive impairment patients in accordance with diagnostic criteria (albert et al., 2011) exclusion criteria: * psychiatric disorders, including major depression, major vascular lesions, and other brain pathologies detected by mri that might present with cognitive decline * a cardio pacemaker or any mri-incompatible metal in the body * epilepsy * any diagnosed psychiatric disorder * alcohol/drug abuse * lack of cooperation * presence of dementia.

Keywords: mild cognitive impairment transcranial direct current stimulation
a study of shj002 sterile ophthalmic solution for myopia control

Conditions: Myopia, Progressive

Summary: the objective of this study is to explore the safety and efficacy of shj002 sterile ophthalmic solution relative to atropine in myopia control shj002 is an antisense oligonucleotide to neutralize a specific microrna.


Eligibility criteria:
inclusion criteria: 1. be male or female, age 3-12 years (inclusive). 2. cycloplegic sphere of -1.00 d or worse in both eyes 3. able to complete all study assessments and comply with the protocol 4. literate or able to orally communicate. 5. parent or guardian able and willing to provide written informed consent 6. parent or guardian able and willing to assure subject compliance with the protocol, follow study instructions, and attend study visits 7. able to tolerate eye drops in both eyes. 8. be able and willing to avoid all disallowed medications and refractive correction 9. for female subjects of childbearing potential (those who have experienced menarche and who are not surgically sterilized \[bilateral tubal ligation, hysterectomy, or bilateral oophorectomy\]), a negative urinary test. 10. women of childbearing potential must agree to use two reliable methods of contraception 11. males not naturally or surgically sterile, who have a female partner of childbearing potential, must agree to use two reliable methods of contraception exclusion criteria: 1. axial length \> 26 mm 2. anisometropia 3. astigmatism \> 2.00 d 4. intraocular pressure \> 21 mm hg or \< 6 mm hg 5. active or recent history of severe ocular infection or inflammation 6. previous incisional or laser surgery 7. any clinically significant finding on slit lamp biomicroscopy or ophthalmoscopy

Keywords: myopia
gabapentin premedication and adenotonsillectomy in pediatric patients

Conditions: Post Operative Nausea and Vomiting (PONV); Adenotonsillectomy

Summary: the frequent incidence of postoperative vomiting and severe pain in children undergoing adenotonsillectomy, may delay postoperative oral intake and increase the risk of dehydration. postoperative nausea and vomiting (ponv) is of multi-factorial origin in this group of patients, with a reported incidence ranging from 23% to 73%. there is growing evidence that the perioperative administration of gabapentinin in adults is beneficial for preoperative anxiolysis, postoperative analgesia, reduction of postoperative nausea and vomiting, and delirium. only few studies in literature explored the analgesic effects of preoperative gabapentin as premedication in pediatric population. however, the antiemetic effect of gabapentin in pediatric patients was not systematically investigated before.


Eligibility criteria:
inclusion criteria: * aged (3-12) * asa physical status i or ii * scheduled for adenotonsillectomy surgery in abu elrish al-mounira hospital exclusion criteria: * patients who have active infection * obstructive sleep apnea * cognitive impairment * abnormal bleeding profile * renal or hepatic dysfunction * history of allergic reaction to study medications or chronic use of anti-consultants will be excluded.

Keywords: gabapentin ponv adenotonsillectomy pediatrics
the effect of interpersonal relationships psychotherapy on breast cancer patients

Conditions: Breast Cancer Patients Diagnosed

Summary: this study is planned to examine the effect of interpersonal relationship psychotherapy on depression, interpersonal emotion regulation and multidimensional perceived social support levels of breast cancer patients with depression risk.

there are not enough studies showing the effect of ipt, which is an evidence-based psychotherapy that works on problem areas such as role change that may occur with the disease and provides support for recognizing and using social support mechanisms, on cancer patients. this study is thought to make a significant contribution to the literature, especially in terms of making family support, which has an important place in social support systems, available to patients, intervening in interpersonal emotion regulation problems that may occur in patients and affecting depression levels.

Eligibility criteria:
includes criteria * ability to communicate in turkish * diagnosed with stage-ii and stage-iii breast cancer * continuing outpatient treatment * four points on the primary care depression screening scale * internet connection * has a phone that can use the zoom app to continue conversations to be * to be able to use the zoom app exclusion criteria * being a pediatric oncology/hematology patient * diagnosed with stage -iv breast cancer * taking psychopharmacological medication * to have received kipt within the last year

Keywords: depression emotion regulation social support interpersonal relationships breast cancer
safety study of botulinum toxin type a in post-upper limb stroke patients with reduced lung function

Conditions: Stroke; Muscle Spasticity; Motor Neuron Disease

Summary: the purpose of this study is to evaluate the safety of injections of botulinum toxin type a in patients with reduced lung function and focal upper limb poststroke spasticity


Eligibility criteria:
inclusion criteria: * abnormal pulmonary function test results; * focal, upper limb spasticity, upper motor neuron syndrome exclusion criteria: * previous exposure to botulinum toxin of any serotype
a randomized clinical trial on supplementation of dha and aa to preterm infants

Conditions: Infant, Low Birth Weight

Summary: a randomized, double-blind trial of docosahexaenoic and arachidonic acid supplementation in breast-fed preterm infants background: docosahexaenoic acid (dha) and arachidonic acid (aa) are essential for preterm infants. human milk and preterm formulas contain dha and aa, but at lower concentrations than required to approximate utero accretion rate. objective: to evaluate the effect of a high dose dha and aa supplement to breast-fed preterm infants in the early neonatal period. primary endpoints are neurodevelopment at 6 and 20 months of age. design: a randomized double-blind placebo-controlled study is carried out in four norwegian neonatal centers. subjects and methods: infants with birth weight \< 1.5 kg are randomized to either an intervention or a control group. all infants receive fortified human milk, and a daily dose of 0.5 ml study oil per 100 ml milk. infants in the intervention group receive oil with dha and aa (formulaid, martek, usa), while the control oil contains vegetable oil without dha or aa. blood samples are collected at birth (cord), and at start and stop of the intervention. plasma is analyzed for fatty acid pattern using high performance liquid chromatography.


Eligibility criteria:
inclusion criteria: * birth weight \< 1500 g * born at one of 4 participating neonatal centers in norway exclusion criteria: * cerebral haemorrhage (stage 3 or 4) * major congenital malformations that are supposed to affect growth and development * illness that require prolonged parenteral nutrition (\>4 weeks)

Keywords: fatty acids human milk infant development very low birthweight infants
a study to evaluate the safety and immunogenicity of ev71 vaccine

Conditions: Enterovirus Infection

Summary: this study is aims to evaluate the safety, reactogenicity and immunogenicity of ev71 vaccine at a 0.25ml or 0.5ml dose in health volunteers

this is a phase i, prospective, randomized, open-label, two-center study. a total 60 healthy volunteers will be screened for baseline characteristic inclusion/exclusion criteria after providing a written informed consent. eligible subjects will be recruited and equally randomized to either receive 2 doses of ev71 vaccine 0.25ml or 0.5ml. all subjects should be followed till day 210.

Eligibility criteria:
inclusion criteria: * subject who is free of obvious health problems * able and willing to comply with the study procedure adn give written informed consent exclusion criteria: * female who is pregnant/lactating or planning to be pregnant * body mass index(bmi) \> 35 * oral temperature \> 37.5 celsius at the time of planned vaccination * subject with any abnormal laboratory results at screening * with a history of herpangina, hand-foot-mouth disease, acute hemorrhagic conjunctivitis or acute gastrointestinal illness associated with enterovirus infection in the past 3 months * has been diagnosed with neurological, pulmonary, cardiovascular, hematological, hepatic or renal disorder * with a history of hypersensitivity to vaccine or allergic disease * use of any investigational/non-registered product within 30 days prior to vaccination * use of immunoglobulins or any blood products within 3 months prior to vaccination * chronic administration of immunosuppressants or other immunomodulators within 5 months prior to vaccination
laboratory study of cannabidiol on the effects of smoked marijuana

Conditions: Smoking, Marijuana

Summary: the objective of this study is to assess the effects of oral cannabidiol (cbd; 0, 200, 400, 800 mg) on smoked marijuana's (0, 5.6% thc) subjective, reinforcing, cognitive, and cardiovascular effects. this experiment is expected to reveal cbd's intrinsic effects when combined with placebo marijuana, as well as its ability to modulate the behavioral effects of active marijuana.

marijuana contains many chemicals called cannabinoids. the ingredient mainly responsible for marijuana's psychoactive effects is called thc (delta-9-tetrahydrocannabinol. another cannabinoid in marijuana is cannabidiol. it is found in smaller quantities than thc. cannabidiol is thought to interfere with the effects of thc. therefore, synthetically produced cannabidiol is given to healthy marijuana users in this study to test its capability to reduce the high of thc and, thereby, help to relieve addiction to marijuana.

Eligibility criteria:
inclusion criteria: * adults between the ages of 18 and 50. * current marijuana use: minimum of four times per week, 0.5 joints per occasion during the preceding 4 weeks. * able to perform study procedures * women practicing an effective form of birth control exclusion criteria: * female subjects who are currently pregnant or breastfeeding. * current, repeated illicit drug use other than marijuana * presence of significant medical illness * history of heart disease * request for drug treatment * current parole or probation * recent history of significant violent behavior * major psychiatric disorder

Keywords: reinforcement, good drug effect, high, mood, cannabidiol
oct in fuchs' dystrophy

Conditions: Fuchs Dystrophy; Pseudophakic Bullous Keratopathy

Summary: this is an observational study using optical coherence tomography (oct) technology to quantify corneal edema in fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.


Eligibility criteria:
inclusion criteria: * damaged or diseased corneal endothelium from fuchs' or pbk * willingness to commit to required study visits exclusion criteria: * prior endothelial keratoplasty (ek) or any other surgery except uncomplicated cataract surgery * presence of a condition that increases the probability for treatment failure (e.g., heavily vascularized cornea, uncontrolled uveitis) * other primary endothelial dysfunction conditions (e.g., posterior polymorphous corneal dystrophy and congenital hereditary corneal dystrophy, iridocorneal endothelial syndrome) * central sub-epithelial or stromal scarring that could impact post-operative clarity assessment * peripheral anterior synechiae in the angle greater than 3 clock hours * hypotony * uncontrolled glaucoma * visually significant optic nerve or macular pathology

Keywords: fuchs pseudophakic bullous keratopathy optical coherence tomography (oct) pbk
a predictive model for recurrent acute pancreatitis

Conditions: Acute Pancreatitis

Summary: the goal of this observational study is to learn about recurrent acute pancreatitis (rap) .the main questions it aims to answer are: 1. what are the risk factors for rap? 2. how to predict rap? all patients with acute pancreatitis will be given standardized treatment for the condition. the researchers will compare the rap group with the non-rap group to find the risk factors for rap.

investigators retrospectively collected data from the medical information mart for intensive care-iv (mimic-iv) database and from patients with acute pancreatitis (ap) in the department of gastroenterology of clinical medical college of yangzhou university between january 2016 and december 2017, forming the primary and validation cohort, respectively.

Eligibility criteria:
inclusion criteria: * meeting the diagnostic criteria of acute pancreatitis (ap) * age ≥18 years * systematic examination and diagnostic information were available after admission exclusion criteria: * not the first episode of ap * the duration of hospital stay was less than 24 hours * died within the first episode of ap * a history of chronic pancreatitis or tumor * pregnancy

Keywords: recurrent acute pancreatitis prediction
comparative outcomes between foot cast and short leg cast in the patients with acute closed fracture of proximal fifth metatarsal (zone ii)

Conditions: Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)

Summary: this study aims to compare outcomes of short leg cast and foot cast for treatment acute fifth metatarsal fracture (zone ii).

a randomized controlled trial will conducts between january 2017 and january 2019, participants with acute fifth metatarsal fracture (zone ii) will recruit for this study at the orthopedic outpatient clinic of a police general hospital, bangkok, thailand. a total of 100 patients will randomly allocate to receive foot cast or short leg cast. acute closed fracture of proximal fifth metatarsal (zone ii) patients.

Eligibility criteria:
inclusion criteria:acute closed fracture of proximal fifth metatarsal (zone ii) with following criteria 1. history of trauma and pain at lateral side of foot 2. tenderness at base of 5th metatarsal 3. radiographic finding shown fracture line at proximal 5th metatarsal bone exclusion criteria: 1. more than 1 week 2. comminuted or multiple fracture 3. open fracture 4. ligament and tendon injury 5. previous injury complication: nonunion, delayed union 6. malignancy 7. refuse to inform consent
therapeutic effects of customized insoles on children with flat foot

Conditions: Flat Foot

Summary: using double blind, randomized controlled design to study the short-term therapeutic effects of customized arch-support shoe insoles to children with flat foot.

a total of 52 children with flat foot will be collected. the participants will be randomized into two groups, including study group (insoles group) and control group (without insole group). all participants in the insoles group will be evaluated at baseline, that is before the customized full-length shoe insoles are prescribed. all the evaluations, including physical functional ability, balance, physical activity, functional performance, and quality of life will be re-evaluated up to 12 weeks after shoe insoles wearing in the insoles group. the control group will be evaluated at the baseline and up to 12 weeks.

Eligibility criteria:
inclusion criteria: * flat foot exclusion criteria: * age less than 3 years old or older than 10 years old * pathological flat foot

Keywords: flat foot therapeutic effect insoles children
the relation between pregnancy,birth outcome, feeding , oral hygiene habits and early childhood caries development.

Conditions: Dental Caries

Summary: * 200 children between ages 36 to 48 months will be invited for a regular dental examination * parameters to be investigated 1. pregnancy history 2. birth outcome 3. child's general health 4. feeding habits 5. oral hygiene habits 6. dmft caries index 7. congenital enamel defects

severe early childhood caries is a condition whereby very young children suffer multiple caries. the value of a pre- perinatal preventive approach is currently being examined in the dental literature. at hadassah, a pilot study is currently underway to test the feasibility of a comprehensive baby clinic designed to prevent severe early childhood caries. the pilot study in cooperation with the woman's health center and with the midwives and the breastfeeding counselors of the maternity unit. lectures are given by pediatric dentists to parents of firstborn children attending hadassah's birth preparation class, emphasis is given to the importance of breastfeeding and other feeding habits in the emotional, physical, nutritional and immunological development of the future baby. in addition the effect of these feeding habits on the dental/oral aspects, relevant for the developing dentition. after birth the parents are invited to come with their babies around 12 months for the first dental examination and follow up according to individual risk for caries development. the current proposed study will be a control group from offspring of women who have participated previous sessions hadassah's birth preparation class ("historical controls" before the baby clinic project)

Eligibility criteria:
inclusion criteria: * children born in previous sessions hadassah's birth preparation class " before the baby clinic project) exclusion criteria: * children not born in previous sessions hadassah's birth preparation class " before the baby clinic project)

Keywords: primary dental prevention early childhood caries prenatal oral care
outpatient treatment of pe and dvt in the emergency department

Conditions: Pulmonary Embolism; Deep Vein Thrombosis

Summary: standardize the approach to outpatient pulmonary embolism (pe) and deep vein thrombosis (dvt) treatment.

in the current protocol, we will study the outcomes most likely to influence emergency physician behavior, such as improved emergency department (ed) throughput, and decreased ed and emergency department observation unit (edou) length of stay. metrics such as decreased admissions are also very important to hospital administrators so our results will have impact outside the ed as well. at the end of this study we will demonstrate that a carefully planned and data-driven approach to the outpatient treatment of pulmonary embolism (pe) is safe, improves operational metrics, and reduces cost.

Eligibility criteria:
inclusion criteria: * subject is 18 years of age or older at time of enrollment. * subject is diagnosed with acute vte (dvt or pe) in the mgh or bwh ed or transferred to the mgh or bwh ed (e.g from a clinic or outside hospital) with a diagnosis of acute vte. * subject is treated as an outpatient (i.e. discharged) directly from the ed or admitted to the ed observation unit/ed short stay unit on the outpatient treatment protocol. exclusion criteria: * subjects admitted from the ed to an inpatient service will not be enrolled as study subjects, but will be used as contemporary controls. * subjects who are unable to understand or provide informed consent. * subjects unable or unlikely to follow up (e.g. prisoners).
renal cell arrest and damage biomarkers in progression and outcome of septic aki

Conditions: AKI - Acute Kidney Injury

Summary: the aim of the current study is to assess the predictive value of renal cell arrest biomarkers (urinary timp2 and igfbp7), renal damage biomarkers (urinary kim-1) and microscopic examination of urinary sediment in progression and outcome of sepsis associated aki.

acute kidney injury occurred in about 45-53% of patients with sepsis, and most septic aki was mild or moderate aki (kdigo stage 1 or stage 2). however, previous study showed that up to 40% of these mild or moderate aki would progress to more severe aki (kdigo stage 3), of which 30% required dialysis and the risk of death increased by 3-fold, as high as 70%. therefore, early identifying patients at high risk for progressive aki might help clinicians to enhance individualized monitoring and personalized management in patient with septic aki, which might prevent or halt the ongoing renal injury and improve the outcome of patients with sepsis.

Eligibility criteria:
inclusion criteria: * aki stage 1 or 2 according to kdigo definition. * sepsis is defined based on the third international consensus definitions for sepsis and septic shock (sepsis-3) as life threatening organ dysfunction caused by a dysregulated host response to infection. at least two of systemic inflammatory response syndrome (sirs) criteria should be present exclusion criteria: * age less than 18 years. * patients with pre-existing chronic kidney disease (egfr\<60 ml/min/1.73m2). * previous renal replacement therapy. * acute kidney injury caused by permanent postrenal obstruction. * pregnancy. * hepatorenal syndrome. * renal transplant recipients. * patients for whom survival to 30 days is unlikely due to end stage disease (end stage liver or heart disease or untreatable malignancy).

Keywords: aki sepsis markers urine sediment