Kornimate/medical-research-clean huggingface dataset:
organoids derived from induced-pluripotent stem cells (ips) from patients with high grade astrocytoma

Conditions: Glioma

Summary: the objective of this study research proposal is to model human gliomagenesis using 3-dimensional (3d) brain organoids derived from human induced pluripotent stem cells (hipscs). the working hypothesis is that 3d brain organoids can develop glioma-like structures and recapitulate phenotypic traits of gliomas when generated from hipscs expressing genetic mutants associated with glioma predisposition. methodology : to develop this pioneer study on the use of hipsc-based brain organoids as a strategy to model gliomagenesis and study the impact of genetic mutants, it will be collect the peripheral blood mononuclear cell from 20 patients with high grade astrocytoma with or without idh mutation. ips will be generated from these pbmc and will be genetically modified according to different mutations. then, it will be generate brain organoids according to standard protocols. brain organoids generated from all different cells will be collected at different time points and analyzed for the presence of glioma-like structures and phenotypic hallmarks of gliomas. from the proposed experiments, it will be expect that brain organoids will develop glioma-like features upon the presence of genetic mutations. thus, it will be expect to demonstrate that brain organoids can be used as a reliable strategy to test the impact of genetic mutants, including the possible synergistic cooperation between different mutations on early gliomagenic events.


Eligibility criteria:
inclusion criteria: * patient, male or female, aged 18 years or older * astrocytoma grades 3 or 4, confirmed by anatomopathological diagnosis * patient having signed an informed consent exclusion criteria: * person in emergency situation, a legal person of legal age (guardianship, guardianship or legal guardianship), or unable to express his / her consent * no affiliation to a social security scheme (beneficiary or beneficiary) * pregnant or lactating woman
national multicentre study of the natural history of acid sphingo-myelinase deficiency in adults and children

Conditions: Acid Sphingomyelinase Deficiency (ASMD); Niemann Pick Disease

Summary: the goal of this study is to describe the natural history of asmd in adult and paediatric patients with or without specific treatment in order to assess the impact of the disease on their daily lives and quality of life. the population concerned corresponds to patients aged at least 2 years, with a definite diagnosis of asmd as determined by a confirmed low acid sphingomyelinase assay and who have not expressed their opposition to participating in this research (patients and/or parental authority).

niemann pick a/ ab/ b disease also known as acid sphingomyelinase deficiency (asmd) is a very rare genetic disease. the natural history remains poorly understood. this disease leads to morbidity and mortality. a specific effective treatment has been available since 2023. the internal medicine department of the groupe hospitalier diaconesses croix saint-simon (ghdcss), reference center for lysosomal diseases, develops this clinical study in order to better understand the natural history of niemann pick a/ ab/ b disease, and better manage the symptoms, the complications and also the impact of this new treatment, particularly on daily life (quality of life). this french multicenter cohort research is coordinated by dr wladimir mauhin, (internal medicine department, ghdcss, paris).

Eligibility criteria:
inclusion criteria: 1. any patient aged at least 2 years, with a confirmed diagnosis of asmd determined by a lowered acid sphingomyelinase assay. 2. have received written and oral information about the protocol and have not expressed opposition to participating in the study. 3. affiliated to the social security system or entitled to benefits (excluding ame). exclusion criteria: 1. inability to understand the information provided, 2. under guardianship, trusteeship or judicial protection, 3. under detention or deprived of liberty by judicial or administrative decision.

Keywords: asmd asmd pick a/a-b/b registry database
comparative efficacy of two preparations of the association diosmin (450 mg) + hesperidin (50 mg) in the treatment of chronic venous insufficiency (cvi)

Conditions: Venous Insufficiency

Summary: it is hoped that with the use of medication, occurs improvement of the cvi parameters, such as edema, pain, night cramps, functional discomfort, heavy feeling and that the drug test is non-inferior than the comparator.


Eligibility criteria:
inclusion criteria: * subjects who agree to the terms described in ic; * subjects of both genders, aged ≥ 18 and ≤ 75 years with ivc framework of the lower limbs; * subjects with cvi ranked 3 to 5, according to ceap scale; * patients complaining of pain and swelling in the lower limbs secondary to ivc; * subjects with good mental health that can respond adequately to the study questionnaires; * subjects who agree to make any return visits for evaluation; exclusion criteria: * patients with cvi classified as 0, 1, 2 or 6, according to ceap; * subjects who have received treatment for varicose veins as laser, medication use topical or oral (eg: brown india, coumarin, and etc.). and surgery in the 03 months preceding the study; * patients with other diseases that may interfere with the study results: thrombosis, coagulation disorders and other diseases that the medical criteria, are important to be excluded; * pregnant or nursing women; * presence of any medical condition that, according to the investigator, should prevent the patient from the study; * participation in clinical trials in the twelve months preceding the study; * patients with serious illnesses and uncontrolled that need multidrug treatment; * patients on diuretics of any kind, regardless of pathology (hypertension, renal or liver disease); * values of laboratory tests appropriate security; the hemoglobin \ 1.5 mg / ml; ast, alt, ggt ≥ 2 times normal values; the platelet count below 90.000/ml; total bilirubin and the fractions ≤ 1.5 times the normal range. * past medical history of hypersensitivity to drugs of the same pharmacological classes of substances under investigation;

Keywords: improvement of cvi parameters
comparison of pharmacological and non-pharmacological interventions for alleviating preoperative anxiety in children

Conditions: Anxiety and Fear

Summary: the purpose of this study is to find out any beneficial effects of electronic devices over preoperative pharmacological intervention in the preoperative period.

preparation for surgery with the induction of general anesthesia can be a stressful experience for a child. preoperative anxiety can prolong induction of anesthesia and postoperative recovery, as well as increasing the risk of postoperative delirium, pain, and analgesic use. pharmacological interventions are associated with increased cost to the hospital, potential surgical delay while waiting for the medication to take effect, and delayed discharge from the recovery room. non-pharmacological modalities comprise education, behavioral techniques, parental presence at induction of anesthesia, and using technology including cellular phones and tablets/ipad, with each category including an array of effective strategies for reducing anxiety.

Eligibility criteria:
inclusion criteria: 1. children aged between 2 and 12 years old 2. asa i and ii 3. informed consent signed by parents or legal guardians exclusion criteria: 1. previous exposure to surgery 2. contraindication to midazolam 3. patients with developmental delay 4. patients with significant visual/hearing problems

Keywords: preoperative anxiety
sleep, pain and stress in adolescents with persistent pain

Conditions: Pain, Chronic; Sleep

Summary: the main aim is the gain information of sleep structures in adolescents with persistent pain. also to study simple interventions to support their sleep and pain management. the main aim of this study is to test the efficacy and feasibility of suggestive presleep relaxation technique in improving sleep quality and sleep-related emotional memory processing.


Eligibility criteria:
inclusion criteria: * patients aged 15-17 years with persistent (\> 3months) pain reporting average pain intensity over 3/10 on the numerical rating scale (nrs). exclusion criteria: * ongoing medication for sleep or pain.
influence of static distal locking of a short proximal femoral nail

Conditions: Hip Fracture

Summary: prospective, comparative, randomized, double-blind study to evaluate the outcomes of trochanteric nailing in unstable hip fractures with and without a distal interlocking screw.

due to the lack of first-level evidence, this study aims to evaluate the effectiveness and safety of surgical treatment for unstable hip fractures, with or without the inclusion of a distal interlocking screw in the hip nail.

Eligibility criteria:
inclusion criteria: * patient over 50 years old * with unstable intertrochanteric hip fracture * operated in the first 48 hours after hospital admission exclusion criteria: * simultaneous associated fractures * fractures with subtrochanteric line * non-acute fractures

Keywords: hip fracture intertrochanteric elderly screw
impact of tai chi in cervical myelopathy

Conditions: Cervical Myelopathy; Balance Assessment; Fall Risk

Summary: the goal of this observational study is to determine if patients with cervical myelopathy who participate in a tai chi program will demonstrate improved gait and balance compared to patients who undergo usual care. participants must be 18 years or older and have a diagnosis of cervical myelopathy.

patients who meet inclusion criteria and choose to participate will be randomized to either participate in a tai chi falls-prevention program or continue with usual care. those in the tai chi program will attend a pre-determined number of tai chi classes for a period of approximately 6-8 weeks. investigators will assess their gait and balance at the time of enrollment and at several timepoints after they have participated in the class (similar timepoints for those randomized to usual care).

Eligibility criteria:
inclusion criteria: * diagnosis of cervical myelopathy with planned surgery * 18 years of age or older * able to participate in intervention (attend and participate in classes) exclusion criteria: * wheelchair bound at initial visit * other verified potential cause of gait instability/balance problems * unable to participate in intervention (unable to attend/participate in classes)

Keywords: surgery
physical activity level of norwegian boys with duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy

Summary: the aim of this population based study is to examine, quantify and describe physical activity level in norwegian boys with dmd, and to compare the level of physical activity level between boys with dmd and age matched healthy boys. a co-project will validate actigraph accelerometry to measure physical activity in boys with dmd.

international guidelines recommend regular physical activity for boys with dmd, and participation in physical activity plays a key role in the management. paradoxically, patients with severe neuromuscular disease like dmd, have considerable limitations to participate in such activities. limitation may be muscle weakness, pain, fatigue, reduced mobility and overall function, and also limited knowledge of physical activity benefits among health care personnel. limited participation leads to a sedentary lifestyle, and gradual under-use of still functioning muscles may cause secondary deterioration in dmd. the current physical activity level amongst norwegian dmd's are unknown, and physical activity registration and self-reported questionnaire will be examined in this study.

Eligibility criteria:
inclusion criteria: * boys with conclusive diagnosis of duchenne muscular disease, attending norwegian pediatric rehabilitation clinics. * signed written consent * able to answer questionnaires with help from parents, care giver(s) or health care professional with regular follow up of the participants. exclusion criteria: * lack of consent. * language difficulties * cognitive dysfunction or mental retardation leading to difficulties in answering the questionnaires adequately

Keywords: physical activity level
prospective research assessment in multiple myeloma: an observational evaluation (preamble)

Conditions: Multiple Myeloma

Summary: the purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (mm) therapies in the newly-diagnosed (ndmm) and the relapsed/refractory mm (rrmm) settings in real-world clinical practice.


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: for rrmm participants who have received at least one prior line of therapy (lot) for mm: * have documented progression from a prior lot * participants who have initiated treatment with one of the following therapies within 90 days before consent for this study or in the case where treatment has not yet been initiated, documentation that the treatment strategy was determined before consent for this study must be provided, and treatment must be initiated within 30 days after consent: * imids * pis * combination of imid + pi * newer agents with novel moas alone or in combination (eg, mabs, hdacis, akt inhibitors, sine, or car t-cell therapies) for ndmm participants receiving frontline therapy: * eligible to receive frontline therapy for mm (no prior mm treatment) * participants who have initiated treatment for mm with one of the following therapies within 90 days before consent for this study or in the case where treatment has not yet been initiated, documentation that the treatment strategy was determined before consent for this study must be provided, and treatment must be initiated within 30 days after consent: * imids * pis * combination of imid + pi * newer agents with novel moas alone or in combination (eg, mabs, hdacis, akt inhibitors, sine, or car t-cell therapies) exclusion criteria: * participants who are currently participating in a clinical trial for mm * participants who are currently receiving treatment for primary cancer other than mm * participants who are not willing or able to provide informed consent * participants who are incarcerated * participants under compulsory detention for treatment of a physical (eg, infectious) or psychiatric illness other protocol-defined inclusion/exclusion criteria apply
risk factor association of musculoskeletal injuries among university students

Conditions: Musculoskeletal Injuries

Summary: this research will be conducted to identify the factors that increase the risk of musculoskeletal injuries in college students, hypothesis: demographic, anthropometric, postural, sleep quality and physical activity characteristics significantly predicted musculoskeletal injury.

an important public health issues for young people, particularly university students is musculoskeletal injuries.the wound may cause excruciating agony, functional limitations,and decreased quality of life (almeida et al.,2013). musculoskeletal injuries have a complicated etiology, with important roles played by demographics, anthropometric, psychological,postural, sleep quality, and physical activity variable.to create focused preventives and intervention measures, it is essential to understand the risk factor of musculoskeletal injuries among university students. questionnaire has been extensively utilized to asses postural risk factor for musculoskeletal illness such as low back pain. musculoskeletal injuries have been linked to possible risk factors related to sleep quality, physical activity in previous study. however it is still unclear how these factor interact in a complex way and how that affects the likelihood of musculoskeletal injury. by examining the association between demographics, anthropometric, phycological, postural, sleep quality and physical activity in university students,this study seeks to fill this vacuum in the literature.the results of this study will offer insightfull information that will help to guide the creation of focused preventives and intervention for this demographics. the date will be collected through the use of structure questionnaire the survey will ask questions on demographics data, psychological aspects, posture, sleep patterns, and level of physical activity and the participants will be required to complete the 9-test screening battery for musculoskeletal damage. the following resources will be utilized to gather information on various aspects of musculoskeletal injuries. age, gender, height, weight, and body mass index (bmi) general health questionnaire (ghq) nordic musculoskeletal questionnaire for posture evaluation (nmq) pittsburgh sleep quality index is used to evaluate sleep quality (psqi) international physical activity questionnaire for measuring physical activity (ipaq) screening for musculoskeletal injuries:9-test msk injury screening battery

Eligibility criteria:
inclusion criteria: * undergraduate students * ages of 18 and 25. exclusion criteria: * graduate students * younger than 18 or older than 25 * who refuse to take part in the study will all be disqualified.

Keywords: posture, sleep, physical activity, demographics
effect of calcium glycerophosphate (cagp) - fluoride dentifrice on dental biofilm ph

Conditions: Dental Caries

Summary: the aim of this study was to investigate the buffering effect of a calcium glycerophosphate-fluoride (cagp-f) dentifrice on in vivo dental biofilm after a cariogenic challenge and evaluate its probable 12-hour protective effect. twelve young adults took part in this randomized, double blind, 14-day 4-phase crossover study. between each phase, the volunteers had a 1-week wash-out period. coded dentifrices were randomly assigned to the volunteers: a) no f and no cagp; b) cagp-only (0.13%); c) f-only (1500 ppm (ppm= parts per million of fluoride which is equivalent to mg/kg)); d) cagp-f (0.13%, 1500 ppm, respectively). the ph measurements were taken from a single-site using a microelectrode, with salt bridge established by a 1m kcl (one molar potassium chloride) solution with a reference electrode. ph measurements were taken at 0 (baseline), 1, 7, 14 and 21 min (minutes) after a cariogenic challenge (10% w/v sucrose solution, %w/v = percent weight per volume). four sets of measurements were carried out: (d0bs) before test dentifrice usage; (d01min) 1-min after test dentifrice usage; and (d712h) 7 days and (d1412h) 14 days using the test dentifrice, 12 hours (h)after brushing. stephen curves and mean auc (area under the curve) were obtained.

although the mechanisms of action of fluoride are reasonably understood, the mechanism of calcium phosphate and calcium glycerophosphate (cagp) are still a matter of debate. it has been suggested that cagp increases the phosphorus content in the biofilm and, as a result, the buffering capacity of the biofilm is intensified. the ph levels of the biofilm are maintained above the 5.0-5.5 range. this is above the critical range for enamel demineralization.

Eligibility criteria:
inclusion criteria: * to live in a non-fluoridated area * to have at least 20 natural teeth * signed a consent form agreeing to carefully follow the research instructions exclusion criteria: * presence of active caries lesions * periodontal disease * use of antibiotics/medication.

Keywords: calcium glycerophosphate fluoride dentifrice biofilm dental caries
unilateral stenting versus bilateral stenting for malignant hilar biliary obstruction

Conditions: Cholangiocarcinoma; Gallbladder Carcinoma; Hepatocellular Carcinoma

Summary: the purpose of this study is to compare the clinical effectiveness and long-term outcomes between patients with malignant hilar biliary obstruction who are treated by unilateral or bilateral stenting.

malignant hilar biliary obstruction is a common clinical manifestation and it can be caused by cholangiocarcinoma, gallbladder carcinoma, liver cancer, or other metastatic carcinoma. most patients with malignant hilar biliary obstruction are unresectable at diagnosis. biliary stenting has been widely used in palliative treatment of malignant hilar biliary obstruction. hilar biliary obstruction usually involves the bifurcation of the biliary tract. some researchers recommended unilateral stenting for malignant hilar biliary obstruction because drainage of 25% of entire liver can achieve the clinical success of biliary drainage. however, some researchers recommended bilateral stenting for malignant hilar biliary obstruction because some researches demonstrated that bilateral stenting can achieve a longer stent patency.in addition, there was no significant difference in post stenting survival between patients who were treated by unilateral or bilateral stenting. therefore, it remains under debate whether unilateral or bilateral stenting is better in the treatment of malignant hilar biliary obstruction. the purpose of this study is to compare the clinical effectiveness and long-term outcomes between patients with malignant hilar biliary obstruction who are treated by unilateral or bilateral stenting.

Eligibility criteria:
inclusion criteria: 1. malignant hilar biliary obstruction; 2. unresectable cases exclusion criteria: 1. bismuth i patients; 2. inability to obtain informed consent; 3. eastern cooperative oncology group performance status of 4; 4. severe dysfunction in other organs.
overeating different fats and influence on muscle mass and body fat accumulation

Conditions: Obesity; Overfeeding; Muscle Mass; Body Composition; Ectopic Fat

Summary: to investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity


Eligibility criteria:
inclusion criteria: * body mass index 25-32 exclusion criteria: * type 2 diabetes * type 1 diabetes * kidney disease * liver disease * abnormal clinical chemistry at screening * intense physical exercise \> 2 hours per week * use of statins or drugs affecting energy metabolism * use of extreme diets

Keywords: overfeeding weight gain liver fat pancreatic fat ectopic fat skeletal muscle adipose tissue gene expression dna methylation palmitate linoleic acid saturated fat polyunsaturated fat metabolism insulin sensitivity