Kornimate/medical-research-clean huggingface dataset:
understanding concussion/mild traumatic brain injury

Conditions: Traumatic Brain Injury; Concussion, Brain

Summary: using the blink reflexometer, athletes are scanned if they are potentially thought to have a concussion during a game or practice.

in a blinded trial, any patient who during a game or practice situation had head contact, thus possible traumatic brain injury (tbi) aka concussion, in addition to the current approved protocols, patients are scanned with the blink reflexometer. results are not available until the end of the season, thus eliminating the potential of someone relying on the results. the blink reflexometer uses 5 puffs of air on the side of the eye over 20 seconds. the air causes a blink reflex which is being correlated to a concussion. the results of the blink post concussion are compared to a baseline scan taken at the beginning of the season.

Eligibility criteria:
inclusion criteria: * read, understand and sign patient consent (parent approval needed when pt is under 18yo) exclusion criteria: * diagnosed concussion in past 4 weeks * ingesting any drugs banned by the us anti-doping association (usada) * never prior diagnosed with a neurological abnormality, including alzheimer's, ms, huntington's, epilepsy, etc.

Keywords: concussion tbi sports medical device fast
development of a novel endoscopic index and patient-reported outcome measure for clinical trials in participants with permanent ileostomy

Conditions: Crohns Disease

Summary: to date, patients with crohn's disease (cd) and permanent ileostomies have been excluded from clinical trials for new treatments. to allow this patient population to be included in clinical trials, outcome and measurement tools are needed. this study aims to develop a patient reported outcome (pro) and endoscopic index (ei) for patients with crohn's disease (cd) and permanent ileostomy. the study will enroll about 50 participants and collect videos of endoscopies that are done as part of standard of care. the videos will be centrally read to identify features that represent a broad range of inflammation and will be used to develop the ei. participants will also be asked to participate in interviews, to understand the symptoms and impacts that are most important to participants for the development of a pro.


Eligibility criteria:
inclusion criteria: 1. adults (age ≥ 18 years) with a diagnosis of cd treated surgically with subtotal colectomy/proctocolectomy end ileostomy at least 12 months prior to the scheduled endoscopy procedure. 2. planning to have an ileoscopy procedure scheduled as part of routine medical care. 3. be proficient in the english language (ie, ability to read, write, speak, and understand english well enough to take part in the interview process without the aid of an interpreter). 4. able and willing to participate fully in all aspects of this study. 5. written informed consent must be obtained and documented. exclusion criteria: 1. end or loop colostomy, end ileostomy for uc, continent ileostomy, ileal pouch anal anastomosis, end ileostomy with mucous fistula, double barrel ileostomy, urostomy, loop ostomy, or any type of end ileostomy not considered permanent at the time of enrolment (with no intent to restore continuity). 2. peristomal skin complications such as pyoderma gangrenosum, abscess, or any other severe peristomal skin inflammation. 3. stomal stenosis obviating ileoscopy, known small bowel stricture, major stoma prolapse, symptomatic parastomal hernia, parastomal hernia with subcutaneous loops of small bowel within the hernia, stoma in a crease/poorly fitting applicable resulting in severe peristomal skin irritation, or retracted stoma that prevents endoscopic evaluation. 4. any actively draining fistula (eg, peristomal or peri-anal). 5. evidence of a known small bowel stricture on cross-sectional imaging or inability to pass an endoscope within the past 6 months. 6. known active clostridoides difficile or other enteric infection. 7. short bowel syndrome. 8. predominant symptom(s) arising from a retained rectal stump. 9. serious underlying disease other than cd that in the opinion of the investigator may interfere with the participant's ability to participate fully in the study procedures or provide nonconfounded descriptions of their cd and ostomy symptom experiences during the interview. 10. prior enrolment in the current study.
the value and mechanisms for monocytes subpopulations in predicting the prognosis of lymphomas

Conditions: Lymphoma,Non-Hodgkin; Diffuse Large B Cell Lymphoma; Peripheral T-Cell Lymphoma

Summary: the purpose of this study is to determine whether the cd16- monocyte/cd16+ monocyte ratio could help predict the prognosis of dlbcl and ptcl.

the investigators plan to prospectively involve 100 non-hodgekin lymphoma patients, including 50 diffuse large b cell lymphomas and 50 peripheral t cell lymphomas without previous treatment from peking union medical college hospital. the following parameters were collected: age, sex, subtype, eastern cooperative oncology group (ecog) performance status (ps), ann arbor stage (i-iv), presence of b symptoms, number and type of involved sites, prognostic index including international prognostic index (ipi) for dlbcland pit for ptcl based on medical record review. all patients would have regular treatment and follow up in pumch. during the follow up, treatment response was evaluated by enhanced computed tomography or pet-ct. the peripheral blood would be collected. the cytodiff flow cytometric technique would be used to test 16 leukocyte subpopulations from peripheral blood at the time of diagnosis, interim of treatment, end of treatment, 1 year follow-up, 1.5 year of follow-up, 2 year of follow up, 3 year of follow-up and disease progression. progression-free survival (pfs) and overall survival (os) would be estimated using the kaplan-meier method and two-tailed log-rank test.the cox proportional hazards model would evaluate prognostic factors for os and pfs. specificity, sensitivity and cut-off would be established using time-dependent receiver operating characteristic (roc) curve analysis. area under curve (auc) values \>0.7 indicate that the parameter can be used for diagnosis, with values \>0.9 indicating high clinical accuracy.

Eligibility criteria:
inclusion criteria: 1. pathologically confirmed diffuse large b cell lymphoma (dlbcl nos, pcnsl, alk+ dlbcl, dlbcl/bl) or peripheral t cell lymphoma (aitl, alcl, ptcl nos, nk/t nasal type, eatl, hstl) 2. no treatment before 3. hcg(-) 4. 18 years old to 80 years old exclusion criteria: 1. other tumors 2. severe infections

Keywords: cd16- monocyte/cd16+ monocyte ratio cytodiff flow cytometric system diffuse large b cell lymphoma peripheral t-cell lymphoma prognosis
biodex balance system in patients with parkinson's disease

Conditions: Parkinson Disease

Summary: conventional balance exercises are an effective rehabilitation method applied in routine rehabilitation programs for parkinson's patients. with technological developments, balance exercises

this study was planned based on the hypothesis that exercises based on visual feedback applied to patients through games will increase patient compliance and improve balance better than conventional exercise.previous studies have shown that the biodex balance device has positive contributions to balance in neurological and orthopedic rehabilitation applications.

Eligibility criteria:
inclusion criteria: * parkinson's diagnosis and hoehn yahr stage i-iii * not changing medical treatment in the last three months * mini mental test score is over twenty-four exclusion criteria: * vestibular hypofunction * neurological disease other than parkinson's disease (multiple sclerosis, stroke, myopathy) * history of lower extremity surgery (such as arthroplasty, anterior cruciate ligament repair) * upper limb amputation in the participant * impairment in cognitive functions * history of psychotic illness * presence of stage 4 gonarthrosis history of malignancy

Keywords: parkinson disease balance training rehabilitation
native alignment in the setting of an arthritic knee in total knee arthroplasty

Conditions: Osteoarthritis (OA) of the Knee

Summary: the goal of this clinical trial is to learn if preparing the target alignment of the operative side in total knee arthroplasty (tka) based on the non-arthritic side will give the patient better overall alignment, function, and improved results compared to basing our implant alignment and positioning off the arthritic side, which is currently the traditional method. the main questions it aims to answer are: * will a patient have improved postoperative tka results if the implant alignment is based off the non-arthritic side compared to the standard arthritic side? * what are the similarities or differences between study arms with respect to final implant alignment and positioning angles? researchers will compare the outcomes of two cohorts of patients undergoing primary robotic-assisted total knee arthroplasty (ra-tka) with normal contralateral knee. based on preoperative ct imaging, the researchers will use normal contralateral side joint numbers as the target alignment for one group (experimental arm) and utilize the traditional method for the other group (active comparator arm). clinical outcomes and patient-reported outcome measures (proms) will be compared between groups. participants will: * be randomized into one of two study arms and will receive either a unilateral knee ct or bilateral knee ct preoperatively * follow-up in the clinic at 2 weeks, 6 weeks and 1-year postoperatively, per standard-of-care for x-ray and clinical evaluation. * complete postop questionnaires (proms) at the prescribed follow-up intervals


Eligibility criteria:
inclusion criteria: 1. patient age is 21-89 at time of surgery 2. patient is indicated to undergo a unilateral primary tka, secondary to osteoarthritis 3. patient's contralateral knee is non-arthritic 4. patient agrees to participate as a study subject and signs the informed consent and research authorization document 5. patient is able to read and speak english. exclusion criteria: 1. patient is under the age of 21 2. patient's primary diagnosis is not osteoarthritis 3. patient is unable to read and speak english 4. history of previous dvt/pe 5. history of stroke, cabg, or a fib 6. current smoker

Keywords: osteoarthritis knee total knee arthroplasty target alignment
post-operative pain following glide path preparation using rotary neoniti gps file and manual k-files

Conditions: Postoperative Pain

Summary: the aim of this study is to clinically compare the incidence of post-operative pain after using rotary glide path file (neoniti gps), on post-operative pain when compared to manual glide path preparation in lower molars with asymptomatic non-vital pulp.


Eligibility criteria:
inclusion criteria: 1. systemically healthy patients (asa i or ii) 2. lower permanent molar teeth with: asymptomatic non-vital pulps, no response of pulp tissue to cold pulp tester (ethyl chloride spray), with or without periapical lesions. exclusion criteria: 1. medically compromised patients having significant systemic disorders. (asa iii or iv). 2. history of intolerance to nsaids. 3. patients with two or more adjacent teeth requiring endodontic treatment. 4. tmj problems, bruxism, clenching or traumatic occlusion. 5. inability to perceive the given instructions. 6. teeth with: vital pulp tissues. association with swelling. acute periapical abscess. mobility grade ii or iii. pocket depth more than 5mm. previous root canal therapy. non-restorability.
a randomized, open-label study on helicobacter pylori eradication with standard triple regimen plus acetazolamide

Conditions: H. Pylori Infection

Summary: helicobacter pylori infection is associated with several gastric diseases, including gastritis, peptic and duodenal ulcers, gastric carcinoma and maltoma. in 1994, the who classified the organism as a type 1 carcinogen. in order to eradicate h. pylori, at least two antibiotics and a proton pump inhibitor are used as a standard therapy regimen. emerging antibiotic resistance to metronidazole or clarithromycin, however, has made successful treatment of infection progressively more difficult, with the success rate of standard triple therapy now at 70%, well below the 80% required for treatment of infectious diseases. therefore, new treatment regimen is required for successful h. pylori eradication. on the other hands, many in vitro studies revealed that bacterial carbonic anhydrase in h. pylori has an important role for surviving of h. pylori in the stomach. it was demonstrated that mutation of carbonic anhydrase affected survival of h. pylori. the investigators therefore expected that administration of carbonic anhydrase inhibitor (acetazolamide) with standard h. pylori eradication regimen would increase the eradication rate. here, the investigators aim to evaluate the efficacy of standard triple regimen plus acetazolamide for h. pylori eradication.


Eligibility criteria:
inclusion criteria: 1. age, between 19 and 70 2. h. pylori infected patients exclusion criteria: 1. previous history of h. pylori eradication 2. previous history of gastrectomy 3. administration of ppi, h2 blocker, antibiotics, or bismuth within 1 month prior to enrollment 4. allergy to sulfonamide 5. electrolyte imbalance 6. adrenal insufficiency 7. pregnancy or breast milk feeding 8. active infection 9. severe hepatic dysfunction 10. severe renal dysfunction 11. severe bone marrow dysfunction 12. significant neurologic or psychologic disease
trauma-focused cbt versus emdr in the treatment of posttraumatic stress disorder

Conditions: Stress Disorders, Post-Traumatic

Summary: this study will evaluate the effectiveness of trauma-focused cognitive behaviour therapy (tf-cbt) versus eye movement desensitization and reprocessing (emdr) in the treatment of trauma survivors with post-traumatic stress disorder (ptsd). patients will be randomly assigned to tf-cbt or emdr. follow-up assessments will be conducted at 3 and 12 months post-treatment. in addition to comparing the efficacy of the two protocols, an additional focus will lie on identifying predictors for treatment outcome.


Eligibility criteria:
inclusion criteria: * a full diagnosis of ptsd according to the dsm-iv or subthreshold ptsd (criteria for intrusive re-experiencing are fulfilled and either three avoidance/numbing symptoms or two hyperarousal symptoms are present) * ptsd is related to one or more single-event traumas and participants have a clear memory of this event/these events (sufficient for constructing scenes to be used in exposure) * age between 18 and 70 * sufficient fluency in dutch to complete treatment and research protocol * if participants are using anti-depressants, they need to be on a stable dose for at least 2 weeks before the beginning of treatment and remain on this dose throughout the treatment. exclusion criteria: * dementia or other severe cognitive impairment * psychosis * depression with suicidal ideation * bipolar disorder * borderline personality disorder * anti-social personality disorder * substance dependence * current use of tranquilizers * exposure to prolonged and/or chronic trauma ("type-ii-trauma")
evaluation of an infant feeding intervention for hiv-exposed haitian infants

Conditions: Lack of; Care, Infant (Child), Malnutrition

Summary: the purpose of this quasi-experimental study is to evaluate the effectiveness of an infant feeding intervention in improving growth and anemia outcomes among hiv-exposed infants 6-12 months of age.

the need for better nutrition during infancy to improve growth and child survival outcomes is well recognized and is especially acute in the context of maternal human immunodeficiency virus (hiv) infection. who guidelines on infant feeding and hiv call for support of hiv-infected caregivers during infant feeding transitions across the first year of life. however, there are few published examples of programmatic approaches that effectively integrate pmtct and infant feeding support at the service delivery level. the objectives of this study are to develop and test an infant feeding support intervention among non-breastfed hiv-exposed infants age 6-12 months enrolled in the prevention of mother-to-child transmission of hiv program at the gheskio centres, an hiv and tb treatment clinic in urban port-au-prince, haiti. the investigators hypothesize that growth and anemia outcomes will be better in the intervention cohort compared to historical controls. the investigators also hypothesize that the infant feeding support intervention will be feasible and acceptable to mothers and clinical staff. to accomplish these objectives, the investigators will enroll 82 hiv-exposed infants age 5.5-6.5 months recruited from the gheskio pediatric clinic in a 24-week intervention that includes a) a daily ration of fortified lipid-based nutrient supplement and b) nutrition counseling delivered through biweekly group and individualized sessions. data on growth, supplement use, infant feeding knowledge and practices will be collected every 4 weeks during the intervention period. hemoglobin and dietary intake will be assessed at baseline, mid-point and end of intervention. intervention children will be seen 6-months post intervention to assess growth and anemia outcomes. growth and anemia outcomes in the intervention group will be compared to medical record data from same-age hiv-exposed children seen at gheskio in the previous year.

Eligibility criteria:
inclusion criteria: * confirmed maternal hiv-infection * age 5.5-6.5 months at intervention start * weight-for-length z-score \> -3 sd (who 2006 reference) exclusion criteria: * confirmed or suspected allergy to peanuts * participation in a concurrent clinical trial at gheskio

Keywords: infant feeding hiv growth anemia
non alcoholic fatty liver disease in rheumatoid arthritis

Conditions: Arthritis, Rheumatoid

Summary: rheumatoid arthritis is a chronic inflammatory systemic disease. it has a worldwide distribution and can affect all age group. the peak incidence is between fourth and sixth decade. it is more prevalent in women, and it's prevalence in the general population in north america is between 0.2-1.5%. the etiology of ra is unknown, although clusters of the disease in families and high concordance in mono-zydotic twins support genetic predisposition. the prevalence of fatty liver disease in patients with rheumatoid arthritis is currently unknown. we wish to study the link between the two conditions by performing a son graphic imaging of the liver in a cohort of ra patients. if indeed a high prevalence of nafld will be found in the ra patients, further support will be landed for the link between inflammation and fatty liver disease. these findings may also have implications regarding the management and follow up of ra patients. the validity of sonographic imaging for detection of fatty liver diseases is currently accepted: on ultrasonographic, fatty infiltration of the liver produces a diffuse increase in echogenicity as compared with that of the kidneys. ultrasonography has a sensitivity of 89% and a specificity of 93% in detecting steatosis and sensitivity and specificity of 77% and 89% respectively in detecting increase fibrosis. in view of all the above data, we expected to find higher prevalence of fatty liver in the patients with higher inflammation markers compare with patients with lower markers.


Eligibility criteria:
inclusion criteria: * rheumatoid arthritis exclusion criteria: * age below 18
the effectiveness of a virtual reality-based multisensory intervention

Conditions: Gynecological Disease

Summary: this study explores the effectiveness of a virtual reality-based multisensory intervention for postoperative recovery in patients receiving gynecological surgery.

this study explores the effectiveness of a virtual reality-based multisensory intervention for postoperative recovery in patients receiving gynecological surgery. the results of the study included postoperative pain response, comfort, and anxiety of the patients.

Eligibility criteria:
inclusion criteria: 1) significant postoperative pain response (vas score over 4); 2) age greater than 18 years and volunteered to participate in this study. exclusion criteria: 1) patients with psychosomatic disorders such as delirium, schizophrenia, and bipolar disorder; 2) patients with epilepsy, motion sickness, lightsensitivity, or other neurological diseases may have difficulty wearing the vr headset; 3) patients have severe heart, liver, kidney, blood, digestive, and nervous diseases.

Keywords: pain management virtual reality gynecology postoperative recovery
ig prx in aecopd: pilot study

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study will look at immunoglobulin (ig) treatment in hospitalized chronic obstructive lung disease (copd) patients with frequent exacerbations. this is a phase ii, pilot randomized double blind control study, meaning this study will help assess if this research can be expanded to evaluate ig treatment in patients with copd. ig treatment is a sterile solution of human immunoglobulin proteins given intravenously (in the vein). immunoglobulins are part of the immune system and help the body fight infections. participants will be assigned to either receiving the ig treatment or normal saline as a control product every 4 weeks for 12 months. participants will continue on current standard therapy as determined by their treating physician.


Eligibility criteria:
inclusion criteria: * hospitalized adult patient with aecopd (clinically dominant aecopd in the case of multiple co-morbidities eg. absence of overt lobar pneumonia or acute congestive heart failure or alternate diagnosis such as acute coronary syndrome or pulmonary embolism) * diagnosis of severe copd (post bronchodilator fev1 \<50%, fev1/fvc ratio \<0.7) made by standard spirometry within previous 12 months or within three days of admission if previous pft data is not available * age \>40 years * \>10 pack year smoking history * at least one copd exacerbation in the previous 12 months before enrollment, defined by having had documented inpatient or outpatient treatment by physician with antibiotics and/or prednisone for physician diagnosed copd exacerbation * expected to live \> 12 months exclusion criteria: * known severe hypersensitivity to immunoglobulin or its components (anaphylaxis) * underlying malignancy (including chronic lymphocytic leukemia) * history of hematopoietic stem cell transplant or solid organ transplant * current treatment with a biological therapy for other conditions * concomitant significant immunodeficiency or on immunosuppressive treatment other than for copd * alpha-1 antitrypsin deficiency * significant proteinuria (dipstick proteinuria ≥ 3+ or known urinary protein loss ≥ 2 g/day or nephrotic syndrome) and/or has acute renal failure and/or severe renal impairment (creatinine more than 2.5 times the upper limit of normal and/or on dialysis) * iga deficiency (iga \<0.1 g/l) * immunoglobulin therapy in the last 12 months or on current ig therapy or have a clinical indication for ig replacement therapy (www.nacblood.ca/resources/guidelines/ivig.html) * obesity (bmi ≥35 kg/m²) * pregnancy

Keywords: aecopd copd