Kornimate/medical-research-clean huggingface dataset:
immunohistochemical expression patterns of microrna processing enzyme dicer in cutaneous malignant melanoma, benign and dysplastic melanocytic naevi

Conditions: Naevi; Malignant Melanoma

Summary: micrornas (mirnas) are very small endogenous rna molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. mirnas bind to their target messenger rnas (mrnas), leading to cleavage or suppression of target mrna translation based on the degree of complementarity. mirnas have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. in the present study the researchers investigate the immunohistochemical distribution of dicer in benign and dysplastic melanocytic naevi as well as in cutaneous malignant melanoma compared to intraindividual healthy control.


Eligibility criteria:
inclusion criteria: * patients with benign melanocytic naevi, dysplastic melanocytic naevi and cutaneous malignant melanoma. exclusion criteria: * patients under 18 years of age * patients with other forms of cancer in previous medical history * pregnancy

Keywords: skin microrna mirna dicer malignant melanoma
trichloroethylene (tce) exposure in an industrial population

Conditions: Parkinson's Disease

Summary: this study is to follow-up with workers from a local company that had exposure to tce that may have symptoms of parkinson's disease. we hope to learn more about tce exposure and parkinson's disease. eligible participants will be those who participated in previous research study entitled "survey of selected exposures and neurologic symptoms in an industrial population"


Eligibility criteria:
inclusion criteria: * previous participant in the research study entitled "survey of selected exposures and neurologic symptoms in an industrial population" exclusion criteria: * not a participant in the research study entitled "survey of selected exposures and neurologic symptoms in an industrial population"

Keywords: parkinson's disease trichloroethylene
influence of compound qingre granule on the inflammatory markers in patient of fuo with excess-heat syndrome

Conditions: Fever of Unknown Origin

Summary: the purpose of this study is to observe inflammatory markers like tnf (tumor necrosis factor), il-1 (interleukin-1), il-6 (interleukin-6),trem-1 (triggering receptor expressed on myeloid cells-1), etc, in patient of fuo with excess-heat syndrome and the influence of compound qingre granule on the inflammatory markers.

all the cases will be provided by the infectious diseases department of beijing friendship hospital.each patient should sign informed consent. assessing the accuracy, completeness, or representativeness of registry data by comparing the data to medical records. after collecting, sorting and entering the data, reducing the missing value, and then checking into the database. the stochastic indicator method will be used to simple random sampling, to ensure the probabilities of each individuals be given chinese medicine intervention are equal.operations must be standard to reduce errors. quality assurance plan: patient of fever within two weeks, or whose temperature is below 38.5 degree centigrade will be excluded. the registration form includes the following parts: name, sex, age, address, phone number, admission time, primary diagnoses and levels of inflammatory markers. data will be analyzed using the spss17.0 (statistical product and service solutions 17.0) statistical software. difference of measurement data will be compared with analysis of variance,and difference of enumeration data will be compared with rank-sum test.p\<0.05 has statistical significance.

Eligibility criteria:
inclusion criteria: * patient of fever of unknown origin (fuo). exclusion criteria: * patient of fever within two weeks, or whose temperature is below 38.5 degree centigrade.

Keywords: inflammatory markers
impact of defecation posture on ease of bowel movements in patients with a rectocele

Conditions: Pelvic Organ Prolapse; Rectocele; Bowel Dysfunction

Summary: the study aims to determine if defecation posture, when using a defecation posture modification device (dpmd), will improve ease of bowel movements in patients with pelvic organ prolapse, specifically rectoceles.


Eligibility criteria:
inclusion criteria: * patients with pelvic organ prolapse, including a rectocele (posterior compartment measurements to stage 2 or greater) that endorse bowel dysfunction, based on our office standard screening questionnaires exclusion criteria: * anyone currently using a defecation posture modification device unwillingness or unable to participate in the study planned travel, inability to use device during the study period patient preparing to undergo pelvic reconstructive surgery prior to the end of the study period presence of ileostomy/colostomy bowel disease such as crohn's disease or ulcerative colitis daily opiate use wheelchair bound if device may pose fall or safety hazard risk to patient, such as need for walker or cane for ambulation. patients weighing over 250 lbs, per manufacturer guidelines for the device inability to understand english pregnant women

Keywords: defecation posture modification device defecation posture
a trial of effectiveness of a smart sensor for continence care: the arcticc study

Conditions: Urinary Incontinence

Summary: the purpose of this study is to compare the use of an electronic incontinence identification system with nursing home support (tena identifi) versus usual care on the quality, resource use and outcomes of continence care for older residents of nursing care homes.

this is a prospective, quasi-experimental, controlled study with a mixed methods design with qualitative and quantitative components.

Eligibility criteria:
inclusion criteria: * nursing homes: a facility which: * provides care for residents over the age of 65 years * has an existing policy for continence care * is registered with the appropriate provincial authorities * engages in recording of the rai- mds v2.0 * residents: nursing home residents over the age of 65 requiring a continence assessment upon entry to the nursing home or requiring a reassessment because of either a change in clinical status or provincial requirement shall be eligible for entry exclusion criteria: * residents * at the end of life, * with profound behavioural disturbances likely to render the use of the tena identifi system impractical * an identifiable, potentially reversible cause for their urinary incontinence (e.g.: acute urinary tract infection) * with double incontinence dominated by faecal incontinence * staff and managers - staff who did not take the training on the identifi system or managers whose units that did not participate in the study will be ineligible for the focus group.

Keywords: nursing homes quasi-experimental mixed methods parallel study urinary incontinence
guided imagery in hospitalized pregnant women

Conditions: Pregnancy

Summary: the study will be carried out in two different groups. participants will be approached after being hospitalized for at least 24 hours. after the pregnant women are evaluated in terms of eligibility criteria for the research, the pregnant women who are eligible will be informed about the research and written informed consent will be obtained from the pregnant women who accept. the random distribution of pregnant women to the study groups will be carried out random.


Eligibility criteria:
inclusion criteria: * being 18 years of age or older * having no difficulties in understanding and speaking turkish * being hospitalized for at least 24 hours * being in the second trimester of pregnancy (14-28 weeks) * having a medically stable condition * experiencing sleep disturbances * voluntarily agreeing to take part in the study exclusion criteria: * having a hearing impairment * having ongoing severe vaginal bleeding * having a diagnosed psychiatric disorder and/or using psychiatric medication * having uncontrolled hypertension * presence of intrauterine fetal demise * premature rupture of membranes (prom) * being in preterm labor
comparative effectiveness of a kinect-based unilateral arm training system vs constraint-induced therapy for children with cerebral palsy

Conditions: Cerebral Palsy

Summary: the aims of the present study is to evaluate the effectiveness of kinect-based upper limb motor rehabilitation system (ulmts) program on motor performance and functional outcomes.

the specific aims of this study project will be: to compare the effectiveness of intervention groups using kinect-based ulmts with constraint-induced therapy on motor improvement in children with hemiplegic cp. the investigators hypothesize that motor improvement in using kinect-based ulmts will be comparable to constraint-induced therapy.

Eligibility criteria:
inclusion criteria are: 1. 3-16 years old 2. diagnosed with congenital hemiplegic or cp with one more affected side 3. considerable nonuse of the affected upper limb. exclusion criteria are: 1. no excessive muscle tone (modified ashworth scale ≤ 2 at any joints of the upper limb) before beginning treatment (bohannon \& smith, 1987) 2. no severe cognitive, visual, or auditory disorders according to medical documents, parental reports, and the examiner's clinical observation 3. no injections of botulinum toxin type a or operations on the upper limb within 6 months.

Keywords: cerebral palsy neurological rehabilitation upper extremity
amantadine and temporal discrimination in patients with traumatic brain injury (tbi)

Conditions: Traumatic Brain Injury

Summary: the study will explore the neurocognitive effect of four weeks of treatment with amantadine versus placebo in patients with traumatic brain injury using the interval bisection timing task. approximately 16 individuals with traumatic brain injury are expected to participate in this study. subject participation is expected to last up to 8 weeks with 16 study visits.


Eligibility criteria:
inclusion criteria: * age 18 to 55 inclusive. history of post-mva close head tbi. female subjects must use an acceptable method of contraception during entire study. acceptable methods of contraception are: history of surgical sterility, postmenopausal status, hormonal contraceptives, or accepted barrier devices (i.e., male/female condom, diaphragm, cervical cap, intrauterine device). exclusion criteria: * current or past history of major psychiatric disorder (schizophrenia, bipolar disorder, major depressive disorder) * substance use disorder * current or past history of serious chronic medical condition (pulmonary (lung), cardiovascular (heart), hepato-renal (liver-kidney) disease, diabetes) * seizures * smoking one or more packs of cigarettes per day * if you are pregnant or breastfeeding, or plan to become pregnant during the study

Keywords: perception of time, traumatic brain injury, amantadine
protein s100 beta as a predictor of resuscitation outcome

Conditions: Cardiopulmonary Arrest Outcome

Summary: management of cardiac arrest is complicated by the lack of a readily available tool identifying individuals who are likely to be successfully resuscitated. s100 beta is a protein that originates in the astroglial cells of the brain, and nse (neuron specific enolase) is another protein that originates in the neurons themselves. in the laboratory, the concentration of these proteins correlate with evidence of brain damage after head trauma, stroke and exposure to low levels of oxygen. the concentration of these proteins in the blood of human survivors of cardiopulmonary resuscitation in humans is much higher than in patients who were resuscitated but did not survive. however, it is still unclear whether survivors from cardiopulmonary resuscitation have higher levels of these proteins in their blood if they survive with neurological injury secondary to the arrest and resuscitation. hypothesis: in humans, the blood concentrations of protein s100 beta and nse during and after resuscitation can predict who will die despite cardiopulmonary resuscitation and who will survive with neurological injury secondary to the arrest and resuscitation.


Eligibility criteria:
inclusion criteria: * all victims of non-traumatic out-of hospital cardiopulmonary arrest (defined as the absence of either spontaneous respiration or palpable pulse or both) within the jerusalem district. exclusion criteria: * patients with do-not-resuscitate orders or an advance directive to that effect. * patients with intracranial hemorrhage
single-sided deafness in the medicare population

Conditions: Hearing Loss, Unilateral

Summary: the purpose of this study is to evaluate the safety and effectiveness of cochlear implantation in adults 65 years of age and older.

the study will be conducted as a single-subject, repeated measures, multi center study at 3 sites. fifteen subjects will be enrolled in this study. three centers in the united states and canada will recruit subjects into this study. study subjects will be followed for 12 months post-implantation of the device.

Eligibility criteria:
inclusion criteria: * 65 years of age or older at the time of implantation * unilateral profound hearing loss, as defined by a pure-tone average (500, 1000, 2000, and 4000 hz) of 90 db or greater in the ear to be implanted * sensorineural hearing loss in the ear to be implanted, as defined by an air-bone gap less than or equal to 10 db at two or more frequencies out of 500, 1000, 2000, and 4000 hz * normal or near-normal hearing in the non-implanted ear, as defined by a pure-tone average (500, 1000, 2000, and 4000 hz) of 30 db or less * word recognition in the ear to be implanted of 5% or less on cnc word score in quiet * previous experience with an appropriately-fit cros, bi-cros, bone conduction, or traditional hearing aid, as deemed appropriate by investigator * fluent in english exclusion criteria: * duration of profound hearing loss of 10 years or more * sudden onset of hearing loss within six months of implantation * evidence of non-functional cochlear nerve or other retrocochlear hearing loss * evidence of severe cochlear malformation (i.e., common cavity or ossification) * external or middle ear infection * suspected cognitive concern * other medical contraindication for surgery or anesthesia
liver transplantation for hilar cholangiocarcinoma in association with neoadjuvant radio- and chemo-therapy

Conditions: Hilar Cholangiocarcinoma; Primary Sclerosing Cholangitis

Summary: single-arm pilot clinical trial. patients with non operable cc associated with psc will be subjected to liver transplantation after a neoadjuvant multimodal therapy protocol. cholangiocarcinoma (cc) accounts for 3% of all gastrointestinal cancers; it is more frequent in patients with primary sclerosing cholangitis (psc), who carry an 8%-12% risk of developing this type of neoplasm. only a minority of patients are suitable for resection partly because of the anatomic position of the tumor (which often arises from the bile duct bifurcation) and partly because of the frequently coexisting liver disease. in fact, cc is currently considered a major contraindication to liver transplantation (olt) at the majority of centers, given a 5-year survival rate of 0%-35%. new strategies have been developed for the treatment of this kind of cancer arising in psc. the nebraska university group showed a 1 and 3 years survival of 55 and 45 % combining a neoadjuvant intra bile duct barchytherapy and 5-fu based chemotherapy with liver transplantation. university of pittsburg proposed also a neoadjuvant protocol prior to liver transplantation based on systemic chemotherapy and external radiotherapy reporting a 53% 5 years survival. more convincing results come from the mayo clinic. an accurate selection of patients and a proper neoadjuvant multimodal therapy (chemotherapy, external radiotherapy and intraluminal bile duct brachytherapy) lead to a 80% 5 years survival after liver transplantation.


Eligibility criteria:
inclusion criteria: * older than 18 years * male or female * diagnosis of cholangiocarcinoma using: * ptbd biopsy or brushing cytology * ca 19-9\>100mg/ml and/or liver mass at ct or mri with malignant stenosis apperance at cholangiography, * non resectable tumour araising above the cystic duct * absence of intra and extra hepatic metastasis * ecog score(eastern cooperative oncology group) 0 * asa score (american society of anesthesiologists) ≤ 3 * ability to understand and willingness to sign the written informed consent form (icf) exclusion criteria: * intrahepatic cholangiocarcinoma * non controlled infection * previous radio or chemotherapy * previsous bile duct resection or attempt to resection * intra and/or extrahepatic metastasis * preivious malignant neoplasm (within 5 years) * execution of trans peritoneal biopsy * tumour diameter more than 3 cm

Keywords: liver transplantation neoadjuvant radio- chemo-therapy
creatine for treatment of depression associated with type 2 diabetes

Conditions: Major Depressive Disorder

Summary: the investigators hypothesize that the administration of a widely available, naturally occurring dietary supplement, creatine monohydrate, will reduce the severity of depression in individuals with type 2 diabetes. the purpose of this study is to determine whether 12 weeks of creatine supplementation is an effective treatment for depression in individuals with type 2 diabetes.

depression is a debilitating illness associated with diminished quality of life and significant personal and societal costs. depression is twice as common in those with type 2 diabetes compared to the general population. antidepressants are commonly prescribed as treatment for depression; however, they may not be the optimal treatment for people with type 2 diabetes. creatine has been shown to decrease symptoms of depression in many types of individuals when used over the course of 8 weeks or more. the purpose of this study is to investigate whether creatine can decrease symptoms of depression in individuals with type 2 diabetes when taken daily for 12 weeks. this study also investigates how creatine impacts brain chemistry as creatine decreases depressive symptoms.

Eligibility criteria:
inclusion criteria: * current diagnosis of major depressive disorder identified by the scid-5-rv * current ham-d score of \> 16 * current type 2 diabetes (as confirmed by clinical history and baseline glycosylated hemoglobin percentage (hga1c) \> 6.5. * diabetes type ii present for at least one year exclusion criteria: * diagnosis of bipolar disorder, schizophrenia, or schizoaffective disorder, identified by the scid-5-rv * history of or current diagnosis of acute kidney injury (aki), chronic kidney disease (ckd) or end-stage renal disease (esrd) * electrolyte disturbance (hypokalemia, hyperkalemia, hyponatremia, or hypernatremia) on screening basic metabolic panel * history of cardiac disease or qtc \>500ms on screening ekg * history of diabetic ketoacidosis or hyperosmolar hyperglycemic state * history of seizure disorder * current serious suicide risk identified by the columbia severity suicide rating scale * positive pregnancy test * breastfeeding * contraindication to an mri scan * current incarceration

Keywords: depression type 2 diabetes creatine diabetes
herbal treatment for attention deficit hyperactivity disorder (adhd)

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the purpose of this study is to determine the safety and effectiveness of an herbal product for the treatment of attention deficit hyperactivity disorder (adhd) in children and adolescents.

adhd is a common childhood disorder associated with concentration problems and disruptive behavior. evidence suggests that herbal remedies may be as effective as standard drug therapies in treating adhd symptoms. this study will determine the safety and efficacy of an herbal treatment in children and adolescents with adhd. this study will last 9 weeks. participants will be randomly assigned to receive either an herbal product or placebo three times a day for the duration of the study. participants will come in for weekly study visits at which their adhd symptoms and any side effects will be assessed by self-report rating scales.

Eligibility criteria:
inclusion criteria: * diagnosis of adhd * score of greater than 1.5 standard deviation above the age and gender norms on the adhd-iv rating scale * parents and children can understand english * parents and children willing to attend all study visits * able to swallow study medication * willing to use acceptable methods of contraception exclusion criteria: * severe depression * history of bipolar disorder, psychosis, severe conduct disorder, or other serious medical conditions * use of medications that may interact with the herbal product * current use of medications to treat adhd * previous use of hypericum * pregnancy

Keywords: adolescent child phytotherapy
effectiveness of antibiotic prophylaxis for totally implantable venous access device

Conditions: Solid Tumor

Summary: this randomized trial is determining the role of antibiotic prophylaxis in the prevention of the infectious complications in patients carrying out totally implantable venous access device.


Eligibility criteria:
inclusion criteria: * older than 18 years of age * have solid tumor * white cells \>4000 * platelets \>100.000 * prothrombin time in normal range exclusion criteria: * drug allergy * diabetes mellitus

Keywords: implantable catheters indwelling catheters infection cefazolin sodium prophylactic antibiotic totally implantable venous access device cancer patients
follow up study(phase 1) to evaluate safety of autologous bone marrow derived mscs in erectile dysfunction

Conditions: Erectile Dysfunction

Summary: this is a 5year (+-30 days) long term follow up study to evaluate the safety of autologous bone marrow derived mesenchymal stem cell in erectile dysfunction subject who participated in and completed the phase 1 trials (refer to clinicaltrials.gov.identifier: nct02344849).

this is a 5year (+-30 days) long term follow up study to evaluate the safety of autologous bone marrow derived mesenchymal stem cell in erectile dysfunction subject who participated in and completed the phase 1 trials (refer to clinicaltrials.gov.identifier: nct02344849). this trial is planned to evaluate the safety of autologous bone marrow derived mesenchymal stem cell in patients with erectile dysfunction subject. subjects who signed this follow-up observation informed consent form will participate in a safety assessment (tumor marker test, serious adverse events, cancer incidence, recurrence of prostate cancer and vital sign).

Eligibility criteria:
inclusion criteria: 1. subjects who treated with mesenchymal stem cell and enrolled the phase 1 study(nct02344849). 2. subjects who can agree to participate in the long term observation study by oneself. exclusion criteria: * not applicable