Kornimate/medical-research-clean huggingface dataset:
effect of antigravity shoes on improving the quality of gait in children with spastic diplegia

Conditions: Cerebral Palsy

Summary: improving the quality of gait in the diplegic children is a major concern in the rehabilitation program. thirty children with spastic diplegia were distributed equally into 2 groups, group a (control) and group b (study). group a had received the traditional physical therapy program for 30 minutes and 30 minutes traditional gait training, while group b had received 30 minutes gait training with antigravity shoes in addition to the traditional exercise program for 30 minutes, percentage of stance and swing phase of gait were measured by 2 d gait analysis for children of both groups pre and after 3 successive months of treatment program, also function level of gait were assessed pre and post treatment by gmfcs .

thirty children with spastic diplegia, their age ranged from 6 to 8 years old, were distributed equally into 2 groups: group a (control) and group b (study) they could walk with limitation or holding on according to gmfcs (level ii \&iii). (palisano et al., 2008). increased time for stance phase and decreased swing phase time was recorded when evaluated by 2d gait analysis. control group (a): the children in this group had received traditional physical therapy exercise program designed for those cases for 30 minutes in addition to gait training program for 30 minutes / day, 3 times / week for 3 successive months. study group (b): the children in this group received the same traditional exercise program for 30 minutes in addition to gait training program for 30 minutes using the antigravity shoes. evaluation was done before and after treatment. treatment include traditional exercises for gait and balance for both groups in addition to use the antigravity shoes for study group.

Eligibility criteria:
inclusion criteria: * 30 diplegic children of both gender aged from 6 to 8, * gmfcs levelii and ii . has gait defecits including percentage of gait cycles. exclusion criteria: * recent surgical intervention. * orthopedic deformity in lower limbs. * sever vision or hearing problems.
a novel electronic method of collecting pain scores in the emergency department

Conditions: Pain, Acute

Summary: can a novel electronic display of pain be successfully used in the emergency department and does it (1) change analgesic prescription and (2) change amount of pain experienced? pain is a common symptom in emergency care. as patients are seldom reassessed, staff may not be aware of pain. currently, members of nursing or medical staff need to ask patients about their pain and record it manually using a visual analogue scale from 0-10. the new electronic display uses buttons to represent a pain scale from 0 (no pain) to 10 (worst pain). patients will select the number that best corresponds to their pain every 15 minutes. in the experimental group, the score will be displayed on a screen. in the control group, the score will not be displayed. the investigators will compare the overall amount of pain in both groups, and will look at their pain management (painkillers prescribed). the investigators will also ask patients and staff for their opinions on the display. the study will include adult patients in the emergency department at leicester royal infirmary with an initial pain score of 5 or more who are able to make a decision about whether to participate. participants will also need to be likely to stay in the hospital for more than 2 hours to allow the investigators to gather enough useful data. the study will recruit 200 participants. if the study can demonstrate that the monitor is acceptable to patients and staff and results in improved pain management, it is a low cost intervention which could be widely implemented within the nhs. it also has the potential for being used in other areas such as surgical wards. the investigators have previously found that 300-400 patients per week in the department have moderate to severe pain and might therefore benefit from this monitor.


Eligibility criteria:
inclusion criteria: * adult (18 years and over) * underlying condition giving rise to significant pain (initial vas pain score of 5 or more) * likely to be staying in the hospital for at least 2 hours * willing and able to give informed consent * able to understand and speak a good level of english exclusion criteria: * children (under 18 years) * patients not willing to undergo routine care (analgesic treatment) * patients who do not have capacity to consent * patients who are unwilling or unable to give informed consent * prisoners * patients who cannot understand the study information in english * currently participating in another clinical trial as far as can be determined from information available at the time of assessment * patients who have a physical or visual disability which will prevent them from holding or using the pain display
effects of autogenic and reciprocal inhibition on trapezitis

Conditions: Neck Pain

Summary: aim of my study is to compare two techniques of mets i.e., autogenic and reciprocal inhibition techniques on pain, disability and range of motion among smart phone user with trapezitis.

study focuses trapezitis in smart phone users. there are many different causes of neck pain, but one common factor is upper trapezitis. this refers to pain and spasms in the neck caused by inflammation of the trapezius muscle. the aim of this study is to compare the effects of autogenic and reciprocal inhibition techniques on pain, range of motion and disability among smart phone user with trapezitis. this study will be randomized clinical trial and 40 patients male and female with age 20 to 40 years having nprs \>3 according to inclusion criteria will be included in the study. they will be allocated into 2 groups by non-probability convenience sampling technique. group a will receive autogenic inhibition technique with conventional physical therapy while group b will receive reciprocal inhibition technique with conventional therapy. outcome measures; neck disability index, goniometry and numeric pain rating scale will measure neck function and neck pain intensity. total 12 sessions, 3 sessions per week for 4 weeks were provided. each session was 45 minutes long and measurements will be taken at the baseline and at the end of 4th week. data will be analyzed by spss version 25

Eligibility criteria:
inclusion criteria: * mobile phone users age between 20 -40 years old. * both gender male and female included. * neck pain (numeric pain rating scale \>3) * with limited neck roms. * ndi scoring 15-24points (30-48%) moderate disability exclusion criteria: * neck pain with whiplash or headache, neurological disorder. * history of previous head, neck, cervical spine or shoulder surgery. * infection or inflammatory arthritis in the cervical spine. * trigger point of upper trapezius will be excluded. * history of cervical radiculopathy. * diagnosed fibromyalgia and myopathy. * history of cancer.

Keywords: trapezitis disability neck pain
co-administration of fosamprenavir with methadone: a drug interaction study.

Conditions: Healthy Subjects

Summary: to assess the combined effects of fosamprenavir 700mg bid + ritonavir 100mg bid + standardized dose of methadone, on plasma total and unbound methadone enantiomer pharmacokinetics (pk), opiate pharmacodynamic (pd) measures, and safety. the effect of methadone on plasma amprenavir pk will also be assessed by comparison to historical control data.


Eligibility criteria:
inclusion criteria: * subject is enrolled in a certified methadone maintenance program for at least 12 weeks prior to period 1, day 1. subject is receiving methadone = 200mg qd that has remained unchanged for 30 days the subject is male, female and is between the age of 18 and 64 years of age. a female is eligible to enter and participate if she is of non-childbearing potential or of childbearing potential. if of childbearing potential, females must have a negative serum pregnancy test at screening, and agree to one of the following: complete abstinence from sexual intercourse from 2 weeks prior to administration of the study drug. sexual intercourse with only vasectomized partner. body mass index of 19.00 to 32.00 kg/m2. willing to refrain from the use of illicit drugs and adhere to other protocol-stated restrictions while participating in the study. able to understand and comply with protocol requirements and instructions and is likely to complete the study as planned. able to give written informed consent prior to screening. exclusion criteria: * subject has a clinically significant abnormality identified on the screening medical or laboratory evaluation, including 12-lead ecg. subject has any preexisting condition which could interfere with the absorption, metabolism, and/or excretion of the study drugs. subject currently has or has a history of decompensated liver disease (i.e., ascites, esophageal or rectal varices, hepatic encephalopathy) or current evidence of active hepatitis (ast or alt \> 2.5x uln). subject has evidence of liver impairment at screening (i.e., inr \> 1.7, total bilirubin \>2.0 mg/dl, albumin \<3.5 g/dl). subject has inadequate venous access. subject has a history of any hypersensitivity reaction to any component of fpv, apv, rtv, or to any drug chemically related to fpv, apv, or rtv.

Keywords: pk pd fpv rtv apv ritonavir fosamprenavir amprenavir methadone pharmacokinetics pharmacodynamics
effectiveness of a nursing intervention for nurses have experienced trauma: a study based on swanson's caring theory

Conditions: Nurses Who Have Experienced Trauma

Summary: this study aimed to (1) develop an internet-based psychiatric nursing intervention, based on swanson's theory of caring, and (2) examine its effects on functional health, resilience, social support, post-traumatic stress, depression, and anxiety. this study was a randomized clinical trial(rct) study with repeated measures to identify the effectiveness of an internet-based psychiatric nursing intervention. participants were evaluated at the following time points: pre-test (pre), post-test (post-test 1, immediately after intervention), and follow-up (post-test 2, one month after the intervention) to assess the sustainability of the internet-based psychiatric nursing intervention. of the 112 women who enrolled in the study, 10 dropped out before post-test 1, resulting in 102 participants who completed all interventions and surveys.


Eligibility criteria:
inclusion criteria: 1. nurse aged from 23 to 40 years 2. a pts score of 64 or lower on the ptsd checklist for dsm-5 (pcl-5) developed by weathers et al., revised by weathers et al., and translated into korean by kim et al., 3. nurse who can access the program through a computer or mobile 4. nurse who understand the purpose of the research and voluntarily agree to participate in the research. exclusion criteria: 1. presence of psychiatric conditions with hallucinations and delusions 2. diagnosis of an intellectual disability that would make understanding the intervention procedure difficult. although a standard cut-off was not present in the pcl-5, women who exceeded 80% (64 points) of the total score were excluded to rule out high-risk women with severe trauma.
characterization of vietnamese patients with obesity at outpatient clinics

Conditions: Obesity

Summary: in the past three decades, obesity has emerged insurmountably, not only in affluent nations but also in many low- and middle-income countries worldwide. it has been linked to various non-communicable diseases, including hypertension, coronary heart disease, diabetes mellitus, dyslipidemia, stroke, colorectal cancer, and many other chronic conditions, such as musculoskeletal disorders, putting tremendous pressure on healthcare systems and the socio-economy. the asia and pacific region harbors the highest absolute number of people with overweight and obese, amounting to approximately 1 billion. in southeast asia, the prevalence of overweight and obesity increased by almost 40% between 1990 and 2013. although vietnam has the lowest percentage of obese adults in the region (about 3.6%), we experienced a 38% increase in the number of obese people between 2010-2014, much higher than that in the university kingdom and the united states (10% and 8% correspondingly). however, the problem is underestimated by not only healthcare professionals but also patients with obesity. these alarms underscore the necessity of implementing a comprehensive assessment and more focused and practical strategies for addressing obesity in vietnam, where data has been limited. therefore, our research has two arms: (1) characterization of patients with obesity to identify those at the highest risks for obesity complications, and (2) understating the attitudes and perceptions of people living with obesity to gain insights into the psychological factors associated with obesity. this research will be a foundation for further research on obesity in vietnam and southeast asia.

all vietnamese, aged 18-65, diagnosed with obesity defined by bmi ≥ 25 kg/m2 as per asia-pacific guidelines for obesity, present at university medical center ho chi minh city and my duc general hospital outpatient clinics, will be enrolled to the study. the patients will have: * standard anthropometric data will be done, using a professional medical hm200p portable height stadiometer and a standardised iso (international organization for standardization) 9001:2015 weight scale, by professional and experienced physicians according to standard study protocol: weight, height, waist and hip circumference, waist to hip ratio, bmi calculated, followed by world health organization guidelines for asian people. * blood pressure measure. * fat mass measured by the tanita mc-780 ma (serial: 17050004). * blood tests: fasting plasma glucose, cholesterol, hdl-c, ldl-c, and triglyceride. * mood disorder screening by answering a patient health questionnaire-9.

Eligibility criteria:
inclusion criteria: * subject is diagnosed with obesity defined by bmi ≥ 25 kg/m2 exclusion criteria: * inability to cooperate with height measurement. * inability to answer questionnaire.

Keywords: obesity vietnamese patients with obesity outpatient clinic
scottish cervical screening and ethnicity project

Conditions: Cervical Cancer

Summary: to identify important ethnic inequalities in cervical cancer screening participation in scotland, and explore possible reasons for these.

the 2011 census database was linked, via the community health index number, with the scottish cervical screening programme data to generate anonymised individual level information on cervical screening participation rates by self-reported ethnic group in scotland. the cohort comprised women (aged 20 to 70) who were living in scotland in april 2011 and took part in the 2011 scottish census, and who were invited to participate in the scottish cervical screening programme between january 2012 and december 2018. all ethnic groups were compared to the population of white scottish women. qualitative interviews were carried out with 50 women (south asian, east european, chinese, black african / caribbean, or white scottish).

Eligibility criteria:
inclusion criteria: * screening invitees through national programme exclusion criteria: * not invited to cervical screening
improving monitoring of patients receiving case management

Conditions: Multiple Conditions; Coronary Heart Disease; Diabetes; Hypertension; Chronic Obstructive Pulmonary Disease

Summary: the uk population is ageing and the likelihood of having a long term health condition increases with age. three out of every five people over 60 in the uk have a long term condition. ageing and having a long term condition increases the chance of having difficulty being independent and carrying out day to day activities. in recent years the nhs has made a greater effort to prevent these difficulties in patients with long term conditions. one approach to help patients with long term conditions is case management, where by (usually) a community matron visits patients at home, looking for early warning signs of any worsening of their condition and arranging care and treatment. but the current way this is done varies across the country and hospital admissions are still rising. in order to give the right care at the right time, effective monitoring is needed to help the community matron detect and act on changes in the patient's condition. loss of muscle strength in old age is linked to a poor health, but it is not known whether simple measures of muscle strength could be used to detect and predict declines in health in the short to medium term to help maintain independence and prevent an accident or hospital admission. the aim of this study is to look at whether monitoring muscle strength in case managed patients is practical, acceptable and useful in detecting when a patient's condition worsens. each patient will be visited by the researcher in their home twice in the first week, then once every two weeks, for another 5 weeks, to carry out three simple measures of grip and respiratory strength, and complete questionnaires about their health and ability to carry out day to day activities. each visit will last about 20 to 30 minutes. a small group of clinicians will be asked about their views of the strength measures. database analysis will allow descriptive data on the patient group to be gathered and analysed.


Eligibility criteria:
inclusion criteria: * patients aged 65 years or over receiving health case management in the community. exclusion criteria: 1. enrolled in any other research study 2. preclude consent: * significant cognitive impairment resulting in lack of capacity to consent. b. unable to communicate without significant aids e.g. non-english speaking. 3. preclude participation/ collection of data * significant emotional distress or psychotic illness active within the last 6 months. * receiving end of life care. * current illness that would preclude data collection. * upper limb pathology that would limit participation e.g. bone fracture within the previous 6 months. * identified as high risk patients with regards to lone working safety by their case manager.

Keywords: case management long term conditions aged sixty five and over
the premod trial: a randomized controlled trial of umbilical cord milking vs. delayed cord clamping in premature infants

Conditions: Intraventricular Hemorrhage

Summary: premature babies can be very sick and have bleeding in the brain. giving babies more blood before cutting the umbilical cord by delayed cord clamping or umbilical cord milking has been shown to reduce the risk of bleeding in the brain. this may be related to improving perfusion to the brain. however, some studies suggest that delayed cord clamping may not increase hemoglobin or blood volume in babies delivered by cesarean section. milking the umbilical cord may give more blood in babies delivered by cesarean section may improve perfusion and reduce bleeding in the brain.


Eligibility criteria:
inclusion criteria: * singleton or multiples pregnancies in patients admitted for medically indicated delivery or in advanced spontaneous preterm labor with imminent delivery at 23 0/7 - 31 6/7 weeks gestation exclusion criteria: * planned vaginal breech delivery * major fetal abnormalities (defined as those that are lethal or require prenatal or postnatal surgery) * fetal death in utero * red cell isoimmunization * patients who are incapable of informed consent (unconscious, severely ill, mentally handicapped), or are unwilling to undergo randomization * placenta accreta or abruption

Keywords: umbilical cord milking delayed cord clamping
dietary effects on weight loss and lipid profile in sedentary women

Conditions: Obesity; Overweight; Life Style

Summary: negative-calorie diet is among the popular dieting guides for weight loss; however, there is still little knowledge about this method. the present study aimed to determine the effects of negative-calorie diet on weight loss and lipid profile, and to compare its efficiency with low-calorie diet.


Eligibility criteria:
inclusion criteria: * non-smokers and weight-stable (± 2 kg, for more than one year) with no history of regular exercise in at least three months before the study. exclusion criteria: * history of cvd and other disorders such as diabetes, depression, eating disorders, chronic medications, kidney disease, cancer, food allergies or intolerances to items used in meals. * subjects with abnormality in thyroid or electrocardiograph, any history of anti-obesity medication or weight loss drugs or dietary supplementations for weight control.

Keywords: caloric restriction diet obesity overweight sedentary lifestyle weight loss women
platelet-rich plasma with topical retinoids versus topical retinoids alone in acne vulgaris

Conditions: Acne Vulgaris

Summary: acne vulgaris is the most common skin disease in adolescents and young adults. adult or post-adolescent acne occurs in 12-14% of this population.it is a chronic, inflammatory disease of the pilosebaceous unit .the clinical features of acne include seborrhoea, non-inflammatory lesions (open and closed comedones), inflammatory lesions (papules and pustules), and various degrees of scarring. platelet-rich plasma (prp) is prepared by simple centrifugation of whole blood to concentrate platelets and simultaneously remove red blood cells. the resultant supernatant is the prp that contains various growth factors, including platelet-derived growth factor (pdgf), transforming growth factor (tgf), fibroblast growth factor (fgf), vascular endothelial growth factor (vegf), and hepatocyte growth factor (hgf).these growth factors are involved in the healing of soft tissue and can regulate cellular processes such as chemotaxis, angiogenesis, mitogenesis, differentiation, and metabolism . topical retinoids are used in the treatment of both noninflammatory and inflammatory acne.food and drug administration (fda) approved three topical retinoids: adapalene, tazarotene, and tretinoin. these agents help normalize follicular keratinization and decrease keratinocyte cohesiveness, thereby reducing follicular occlusion and comedon formation .topical retinoids also compete with factors involved in the acne inflammation response, enhance penetration of other topical acne medications, and accelerate the resolution of acne-induced post-inflammatory hyperpigmentation. updates from the global alliance on improving outcomes in acne consider topical retinoids as first-line therapy, individually or in combination with benzoyl peroxide. however, the common side effects of skin irritation and discomfort may impede adherence to long-term therapy. for patients with acne, combination therapy with a topical retinoid and platelet-rich plasma (prp) has not yet been tested. prp with topical retinoids will be evaluated and campared with topical retinoids alone in acne tretment.


Eligibility criteria:
inclusion criteria: * patients with facial acne vulgaris * age from 12 to 35 years old exclusion criteria: * pregnant or lactating women. * patients with history of coagulation disorders. * chronic diseases (chronic renal failure, hepatic insufficiency, cardiovascular disorders, uncontrolled diabetes mellitus, thyroid disorders, anemia, autoimmune diseases). * patients with unrealistic expectations. * patients received any systemic treatment in the last 6 months.