Kornimate/medical-research-clean huggingface dataset:
personalized education and genetic counseling to increase genetic testing in patients with a known family history of pancreatic cancer

Conditions: Pancreatic Carcinoma

Summary: this clinical trial studies whether personalized education and genetic counseling increases genetic testing in patients with a known family history of pancreatic cancer. approximately 10% of pancreatic cancer cases are genetically linked and therefore, if a gene is found that could put a patient at risk, it could guide the patient to obtain more frequent screening for pancreatic cancer and possibly detect it earlier when it is more treatable. the current national comprehensive cancer network (nccn) guidelines suggest patients with a first-degree relative (parent, sibling, child) with pancreatic cancer be referred for a genetics consultation to discuss genetic testing if the affected family member cannot be tested. personalized education is based on the patient's family history of pancreatic cancer and offers information regarding the current nccn guidelines. this may be an effective method to increase patients' understanding of their pancreatic cancer risk and the nccn guidelines. genetic counseling is provided by an expert in hereditary disorders. the patient's family and personal medical history may be discussed, and counseling may lead to genetic testing. personalized education and genetic counseling may increase genetic testing in patients with a known family history of pancreatic cancer.

primary objectives: i. perform housing-based socioeconomic status (houses) index analysis on 500 patients with a first-degree relative diagnosed with pancreatic cancer to see if there is a correlation with the national comprehensive cancer network (nccn) criteria. ii. offer 40 patients who did not have appropriate nccn intervention the opportunity to have a genetic consultation (to consider genetic testing). iii. survey patients on their knowledge and experiences of genetic testing based on family history and their decision-making when offered genetic counseling and testing. outline: patients receive a personalized message through the mayo portal (epic) with education on the nccn guidelines for genetic counseling and an offer for standard of care (soc) genetic counseling. patients then receive pre-genetic test counseling on study. patients may then optionally undergo soc genetic testing and collection of blood or saliva samples as well as receive post-genetic test counseling on study.

Eligibility criteria:
inclusion criteria: * age: 18-75 years of age * first-degree relative with pancreatic cancer listed in the epic family history tool * active patient at mayo clinic florida (mcf) (visits within 1/1/2023-12/31/2023 to family medicine and/or gastroenterology and hepatology) exclusion criteria: * patients not meeting the inclusion criteria as defined above * patients with an active or past history of pancreatic cancer * patients who are pregnant or breastfeeding
24-hour blood pressure dynamics and autonomic adrenergic regulation in type 2 diabetics

Conditions: Diabetes Mellitus, Type 2; Polyneuropathy Diabetes; Autonomic Neuropathy; Diabetic Neuropathies; Diabetic Complications Neurological

Summary: autonomic neuropathy is a common complication of type 2 diabetes mellitus. symptoms from cardiovascular autonomic neuropathy include, dizziness, orthostatic hypotension and insufficient heart rate and blood pressure (bp) regulation during physical exertion. the degree of cardiovascular autonomic neuropathy is most commonly measured as cardiac autonomic neuropathy based on at least two abnormal cardiac reflex tests, which primarily measures parasympathetic indices of the autonomic nervous system (ans). few measures are available for quantifying the sympathetic/adrenergic branch of the ans. circadian changes in bp is a documented measure of bp variability, regulated centrally by a multitude of centers. a growing number of studies indicate that a diminished bp variability is associated with increased cardiovascular risk and injury. the ans plays a pivotal role in the execution of these circadian bp changes, mainly through sympathetic adrenergic nerve fibers few studies have investigated the applicability of 24-hour indices as predictor for autonomic adrenergic dysfunction. no previous studies have investigated the association between clinical markers of adrenergic function, and 24-hour blood pressure indices in type 2 diabetes.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * normal 12-lead ecg exclusion criteria: * significant cardiovascular, muscular, lung, kidney or psychiatric disease * pregnancy * malignant disease, hiv, alcoholism or drug abuse * parkinson disease * ischemic heart disease * vital medicine that can affect the autonomic nervous system
early detection of glioblastoma multiforme (gbm) treatment responses using multiple magnetic resonance modalities

Conditions: Glioblastoma Multiforme

Summary: the purpose of this study is to determine whether dynamic contrast enhanced mri (dce mri) and high diffusion weighting mri may be used to distinguish between favorable and unfavorable responses to therapy of glioblastoma multiforme. imaging data will be correlated with histopathologic findings and clinical responses to radiation therapy with or without chemotherapy.


Eligibility criteria:
inclusion criteria: * the presence of a primary brain tumor that cannot be completely resected that requires radiation therapy with or without chemotherapy. exclusion criteria: * patients who do not have a primary brain tumor or who are unable to tolerate the environment of the mri scanner
the impact of reformulated foods on cardiovascular risk factors

Conditions: Type 2 Diabetes Mellitus; Cardiovascular Disease; Obesity

Summary: specific policies on obesity reduction often include a recommendation to reduce sugar consumption as a means of lowering overall caloric intake. reformulating processed foods (e.g. sugary products) is considered one of the key options for improving population diet. the implications of regular consumption of reformulated products are not fully understood. previous studies have demonstrated that dietary compensation is common, although the extent is not fully elucidated. in addition to the perceived impact of sugar consumption on weight control, high sugar intake, specifically sucrose and fructose, has been implicated in the increase of plasma lipids and markers of insulin resistance. however to date no randomised controlled study has investigated whether the consumption of reformulated low sugar products as components of a habitual diet have a significant impact on plasma lipid, insulin or glucose concentrations within a free-living, non-diseased population. it is hypothesised that exchange of reformulated, low sugar food products for habitually consumed foods will result in dietary compensation and minimal weight change compared with unmodified products and will have little impact on plasma glucose, insulin and lipid levels.


Eligibility criteria:
inclusion criteria: * age: 20 - 49 years * bmi 18.5 - 30 kg/m2 * plasma glucose \<7 mmol/l (not diagnosed with diabetes) * plasma cholesterol \<7 mmol/l * plasma tag \<2.3 mmol/l * normal liver and kidney function * haemoglobin (\>110 g/l women; 140g/dl men) exclusion criteria: * having suffered a myocardial infarction/stroke in the past 12 months * diabetic (diagnosed or fasting glucose \> 7 mmol/l) * smoking * on drug treatment for hyperlipidaemia, hypertension, inflammation or hypercoagulation * suffering from renal or bowel disease or have a history of choleostatic liver or pancreatitis * excessive alcohol consumption * history of alcohol abuse * following a reducing diet or vegan diet * taking any fish oil, fatty acid or vitamin and mineral supplements * participating in intensive aerobic activity for \> 20 minutes 3 times per week * food allergies * anti-inflammatory usage
combined treatment of rfa and sorafenib on recurrent hcc

Conditions: HCC; Radiofrequency Ablation; Sorafenib

Summary: rfa is a routaine treatment of recurrent hcc. recently sorafenib was reported to be a promising drug to treat late stage hcc. but few studies were related with its effectiveness on recurrent hcc. so the investigators hypothesized that combined rfa and sorafenib might reduce the frequency of recurrence and improve the overall survival and disease free survial.


Eligibility criteria:
inclusion criteria: * recurrent hcc after curative resection * without gender restriction * age between 18 to 75 years * the liver function showed no worse than child-pugh b * tumor nodes were less than 5cm and no more than 3 nodules exclusion criteria: * pregnancy patients * with extrahepatic tumor or lymphnode metastasis * tumor invasion or thrombosis in portal vein,hepatic vein or inferior vena cava
a study of bevacizumab (avastin) in combination with neoadjuvant treatment regimens in participants with primary human epidermal growth factor receptor 2 (her2) negative breast cancer

Conditions: Breast Cancer

Summary: this study will evaluate the effect of bevacizumab in combination with chemotherapy or endocrine therapy, as preoperative treatment, in participants with her2 negative breast cancer. participants will be randomized to receive either chemotherapy (fec100: epirubicine 100 milligrams per square meter \[mg/m\^2\], 5-fluorouracil 600 mg/m\^2, and cyclophosphamide 600 mg/m\^2\] for 12 weeks followed by taxane (paclitaxel/docetaxel) for 12 weeks or endocrine therapy (an aromatase inhibitor\] daily for 24 weeks) with or without bevacizumab (15 milligrams per kilogram \[mg/kg\] as intravenous \[iv\] infusion every 3 weeks up 24 weeks).


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed, her2-negative, men or pre- or post-menopausal women with primary operable adenocarcinoma of the breast, greater than or equal to (\>=) 2.5 centimeters (cm) in size * eastern cooperative oncology group (ecog)/world health organization (who) performance status less than or equal to (\</=) 2 * normal baseline cardiac function (left ventricular ejection fraction \[lvef\]) exclusion criteria: * stage iv (metastatic) disease * previous treatment for localized breast cancer less than (\<) 24 months from diagnosis of present breast cancer * other previous or current cancer except for basal cell cancer or in situ cervical cancer * current or recent use of aspirin (greater than \[\>\] 325 milligrams per day) * clinically significant cardiovascular disease
artificial oocyte activation

Conditions: Infertility; Ovarian Insufficiency

Summary: studies reported that calcium signal deficiency or insufficiency during oocyte activation are related with embryo arrest and blastocyst quality. the utilization of artificial oocyte activation (aoa) is safe and does not increase birth defects, cognition, language and motor skills. aoa is the first line of treatment in patients with globozoospermia (round headed spermatozoa). poor responders in in-vitro fertilization (ivf) cycles represent a major challenge for fertility specialists and comprises about 10-15% of patients undergoing controlled ovarian hyperstimulation. the absence of synergy between the oocyte and sperm leads to a negative impact on oocyte activation. the european society of human and reproduction (eshre) recommends aoa in cases with failed fertilization/ low fertilization.


Eligibility criteria:
inclusion criteria: * patients with poor or no blastocyst development in their primary cycle * group 1 - second cycle using aoa following the poor blastocyst development cycle * group 2 - second cycle without aoa following the poor development cycle exclusion criteria: * all cycles who do not have repeat cycles following the poor blastocyst development cycle
analgesic efficacy, safety and tolerability of two paracetamol-containing solutions in post-surgical hip replacement pain

Conditions: Pain, Postoperative

Summary: the aim of the study is to evaluate the therapeutic efficacy, safety and local tolerability of two different paracetamol-containing solutions in postoperative total hip replacement. they will be compared to placebo (a dummy treatment which contains no active ingredient).


Eligibility criteria:
inclusion criteria: * asa i, ii or iii and scheduled for elective total hip replacement, using a standard approach and a cemented implant. * moderate or severe pain within 4 hours after stopping the pca in the morning of the first post-operative day. exclusion criteria: * another acute or chronic painful physical condition * use of any other analgesics (within 24 hours), sedatives, or narcotic drugs as well as microsomal enzyme inducers * inability to use and understand visual analog scale and verbal rating score

Keywords: pain, postoperative replacement, total hip total hip replacement arthroplasty, replacement, hip
acute renal injury associated contrast in intensive care unit patients

Conditions: Acute Renal Injury

Summary: generally, a contrast medium is used when performing a ct scan or radiographic tests such as angiography because it heightens image clarity and can increase diagnosis accuracy. despite these advantages, contrast media can cause allergic reactions in the body or a decline in renal function. therefore, they should be handled carefully and explained sufficiently to the patient. for intensive care patients, the use of contrast agents has been revealed as a major cause of acute renal damage, and many studies have investigated this complication by examining incidence rates and prevention strategies. hypothesis: among intensive care patients, the group in which a contrast medium was used will have a higher risk of renal function decline compared with the group in which a contrast medium was not used, and, hence, the use of contrast media becomes a cause of renal function deterioration. categorizing patients with renal function decline according to the new rifle criteria can have an association with the prognosis of intensive care patients, such as hospitalization period and death rate, which can promote faster intervention.


Eligibility criteria:
inclusion criteria: * for the 5 years from january 2008 to december 2012, patients in whom a contrast medium was used in the intensive care unit were examined. exclusion criteria: * for the 5 years from january 2008 to december 2012, patients in whom a contrast medium was not used in the intensive care unit were examined.

Keywords: contrast intensive care unit acute kidney injury
the impact of paediatric use of proton pump inhibitors on the risk of community acquired infections.

Conditions: Community Infections

Summary: pharmacological treatment of physiologic gastro-esophageal reflux disease (gerd) is excessive in france, as 65%-85% of children below 11 years are being treated, frequently with proton pump inhibitors (ppis) ppi have been associated, in adults, with an increase of infection rate but data in pediatry are scarce, especially in community medecine. recently a study conducted in england brought up controversial results suggesting that the use of ppis can be associated with a reduced risk of community acquired pneumonia. our study was aimed to assess, on a population-based database, the association between ppi prescription and community infections in children of 11 years or under.


Eligibility criteria:
inclusion criteria: * children aged 11 years or below with at least 2 consultations during the follow up exclusion criteria: * chronic pulmonary or cardiac * muscoviscidosis * immunodeficiency * h. pylori infection * diabetes * denutrition * known digestive upper tract malformation
music therapy in obsessive compulsive disorder

Conditions: Obsessive-Compulsive Disorder; Anxiety; Depression

Summary: previous studies have highlighted the potential therapeutic benefits of receptive individual music therapy as an adjunct to standard care, in a variety of psychiatric ailments including mood and anxiety disorders. however, the role of music in the treatment of obsessive compulsive disorder have not been investigated to date. the present study therefore aimed to investigate the efficacy of music therapy as an adjunct to standard treatment, on obsessions in patients with treatment-naïve ocd. moreover, given the fact that a significant proportion of patients with ocd have other comorbid mood or anxiety disorders, the question of whether therapeutic benefits of music could be expanded to also affect concurrent depressive and anxiety symptoms was explored.


Eligibility criteria:
inclusion criteria: * were at least 18 years or older; * had axis i diagnosis of ocd according to the criteria delineated by the diagnostic and statistical manual of mental disorders - fourth edition diagnosed by an experienced psychiatrist * had not received treatment previously for the disorder * agreed to partake in the study exclusion criteria: * refused to partake in the study

Keywords: obsessive compulsive disorder music therapy/methods combined modality therapy anxiety disorders/therapy
primary colorectal signet ring cell carcinoma and the risk of multiple primary gastrointestinal malignancies

Conditions: Colorectal Carcinoma; Cancer; Signet Ring Adenocarcinoma of the Colon

Summary: this original research investigates the critical issue of gastrointestinal (gi) second primary malignancies (spms) in patients with signet ring cell carcinoma (srcc), a rare and aggressive subtype of colorectal cancer. utilizing the surveillance, epidemiology, and end results (seer) database, the investigators assessed the risk of gi spms, particularly within 2-11 months post-srcc diagnosis.


Eligibility criteria:
inclusion criteria: * patients diagnosed with primary colorectal srcc between 2000 and 2021 * latency exclusion period of two months exclusion criteria: * patients with unknown age data

Keywords: signet ring carcinoma seer cancer
bone marrow concentrate (bmc) injection in intervertebral discs

Conditions: Low Back Pain; Disc Disease; Disc Degeneration; Arthropathy Vertebrae; Sacral Disorder; Radiculopathy; Spinal Stenosis

Summary: intradiscal delivery of bone marrow concentrate (bmc) into discs, facet, epidural space, and sacroiliac joints

to study if the outcomes for the injection of bone marrow concentrate (bmc) in patients with disc, facet, epidural space, and sacroiliac joint pain create a clinically meaningful improvement in pain and function. further analysis will determine if there be any variance in patient reported outcome due to the individual's pre-procedure cell count and analysis. hypothesis 1: an injection of autologous bmc into discs, facets, sacroiliac joints, and epidural space will improve pain and function in patients with idd hypothesis 2: there will be a direct relationship between an individual's bmc composition and the patient's reported outcomes

Eligibility criteria:
inclusion criteria: * a high index of suspicion for discogenic pain, i.e. painful degenerative discs with or without protrusions/herniations and facet/sacroiliac joint pain * patients with mild to severe spinal stenosis * patients with radiculopathy * patients with disc extrusions * patients with failed spinal fusion * patients with mild to severe facet arthropathy * patients with suspected sacroiliac joint disease * age 18 to 60 years * mild to severe loss of intervertebral disc height * pain is not responsive to conservative treatment measures (oral medication, epidural steroid injections, physical therapy) * pain persists for an extended period of time (i.e., at least 3 months) * high intensity zone (hiz) in annular fissure or adjacent to annular fissure detected on t2 or stir mri * no evidence of contraindications to undergo procedure such as pregnancy, active infection, bleeding disorder, or metastatic cancer * english speaking exclusion criteria: * spinal deformity (scoliosis \>20 degrees, spondylolisthesis) * sequestered fragments, severe thecal sac compression * severe neurologic deficit * non-english speaking * bone marrow disorders * immunosuppressed patients * patients with coagulopathy * localized infection in the area of skin penetration * spinal infection * serious medical co-morbidities

Keywords: stem cells bone marrow concentrate disc minimally invasive injections facet joint sacroiliac joint epidural space
dxr stent for vascular healing and thrombus formation: oct study

Conditions: Coronary Artery Disease; Coronary Stent Occlusion

Summary: the purpose of this study is to evaluate the efficacy of a novel dual drug-eluting stent (dxr stent), which slowly releases both cilostazol and paclitaxel, for strut coverage, malapposition, and thrombus formation, assessed by an optical coherence tomography.


Eligibility criteria:
inclusion criteria: 1. patient * age \>=19 years * clinically indicated to invasive coronary angiography * patient capable and willing of giving written informed consent 2. angiographic * coronary artery disease confined to native coronary artery * \>50% diameter stenosis by invasive coronary angiography * reference diameter 2.5-4.0mm, lesion length ≤30 mm exclusion criteria: 1. patient * inability to provide written informed consent * serious comorbidity which may affect the trial by decision of investigators * prior cabg to target vessel * congestive heart failure with nyha class iii or iv or left ventricular ejection fraction less than 30% * prior st elevation myocardial infarction within 72 hours from the procedure * hemodynamic or electrical instability including shock * serious coronary artery spasm, unrelated to catheter * pregnancy or possible pregnant status * allergy to iodinated contrast agent * serum creatinine \>=1.7 mg/dl or creatinine clearance \<= 30 ml/min * st elevation myocardial infarction 2. angiographic (oct) * left main disease * severely calcified lesion * severely tortuous, or timi flow grade 0 or 1 by angiography, or inappropriate for oct procedure by investigators' decision

Keywords: optical coherence tomography drug-eluting stent
smart wearable insights to prevent exacerbations and recurrence - rehabilitation study: swiper-rehab

Conditions: Cardiovascular Diseases

Summary: aims of the study: * to measure the rate of completion of a digital cardiac rehabilitation programme at imperial college healthcare nhs trust (ichnt) * to measure the health economic impact of a digital cardiac rehabilitation programme at ichnt any adult patient eligible for ichnt cardiac rehabilitation (cr) programmes is eligible to participate. participants will receive a commercially available smart watch and be asked to wear the device as much as possible. in addition, they will be asked to download a smartphone application called 'imperial healthy hearts', which displays movement and information on heart rate, breathing and oxygen levels to both the participant and the research team (digital data). the healthy hearts app also allows the direct care team to provide educational materials to patients as part of their routine care. the clinical content and structure of the cr programme is determined by the clinical cr team, and does not deviate from established local and national standards and practices. researchers will capture physiological data such as heart rate, respiratory rate, blood pressure (where available) and oxygen saturation (where available) via the healthy hearts platform. researchers will also capture clinical information from the electronic health record, and will compare cr programme uptake and completion rates with historical data and national targets.


Eligibility criteria:
inclusion criteria: * age 18 years or above * able to give informed consent * eligible for cardiac rehabilitation programme exclusion criteria: * any wrist wound, skin pathology or other feature that would prohibit the wearing of a smartwatch * any visual impairment preventing the use of the fitbit or smartphone application.

Keywords: cardiac rehabilitation prevention digital health smart wearables remote patient monitoring