Kornimate/medical-research-clean huggingface dataset:
analytical and functional evaluation of recovery following acute rupture of the achilles tendon and surgical repair in young patients

Conditions: Acute Unilateral Rupture of the Achilles Tendon

Summary: acute rupture of the achilles tendon is a very frequent sports injury. surgical repair is the usual treatment in young subjects, and although the optimal technique is still a matter of debate, conventional surgery with a direct approach is still the reference technique in young sportsmen and women. studies investigating the evolution of ankle muscle strength following surgery for a ruptured achilles tendon are rare, even though it is a crucial criterion to determine the possibility of returning to the sport. this project thus proposes to study, in comparison with the healthy ankle:(1) the evolution of muscle strength in the flexors/extensors and invertors/evertors of the injured ankle, evaluated using an isokinetic dynamometer, and (2) the evolution of stabilometry parameters, at 6 months, then at 12 months, following surgery for acute unilateral rupture of the achilles tendon, operated on using the conventional technique in young sportsmen and women and in comparison with the healthy side.


Eligibility criteria:
inclusion criteria: * persons informed about the research * sportsmen and women (competition or leisure, practiced \> 3h/week) * between 18 and 45 years old * first episode of acute traumatic unilateral rupture of the achilles tendon * open surgery in the orthopaedic and traumatology department of dijon university hospital * identical post-operative immobilisation programme for 6 weeks * absence of major post-operative complications delaying the rehabilitation exclusion criteria: * persons without national health insurance cover * concomitant joint disease that could be aggravated by the tests * heart disease/contra-indication to effort required during the isokinetic test * management other than open surgery (orthopaedic, functional, percutaneous surgery, ...) * rupture of the contralateral tendon * contra-indication for the use of the biodex s4 pro
results of bile and blood culture in patients with acute cholangitis

Conditions: Cholangitis

Summary: cholangitis is a complication of biliary statsis. bile juice is sterile when there is no obstruction, however, it can be infected with bacteria when there is a stasis or obstruction. after infection, cholangitis can be developed because of systematic endotoxemia or bacteremia. though identification of bacteria is very important for selection of adequate antibiotics, treatment with empirical antibiotics is commonly performed when identification of bacteria is not possible. identification of bacteria is usually done with blood or bile culture. in the previous studies, the same results from blood and bile were common in patients with cholangitis. however, the data of these studies were based on the bile juice which was aspirated by surgery. considering that bile duct obstruction is usually treated with endoscopy or radiological intervention without surgery, it is necessary to collect data with endoscopic or radiologic intervention. in addition, the concordant rate of these two tests has not been reported according to severity of cholangitis. as a result, the necessities of bile and blood culture are not agreed among experts in this fields. our hypothesis is that concordant rates of bile and blood culture are same in patients with each moderate or severe cholangitis. however, the concordant rates of bile and blood culture are different between patients with moderate and severe cholangitis. this study will assess the positive rates of blood and bile culture in patients with moderate or severe cholangitis, respectively and compare the results according to the different severity.


Eligibility criteria:
inclusion criteria: * patients with moderate or severe cholangitis which fullfilled the criteria by the tokyo guidelines (tanaka a, takada t, kawarada y, et al. antimicrobial therapy for acute cholangitis: tokyo guidelines. j hepatobiliary pancreat surg 2007;14:59-67.) * patients who are successfully treated with endoscopic or radiologic biliary drainage * patients who undergo both blood and bile culture tests exclusion criteria: * patients with other infections except cholangitis or cholecystitis * patients who received surgical biliary drainage treatment * patients who are treated with endoscopic or radiologic biliary drainage more than 24 hours after using initial antibiotics * patients who does not agree with informed consent or who are vulnerable subjects

Keywords: cholangitis bacteremia endotoxemia blood bile
effectiveness of probiotics prophylaxis of urinary tract infections in children

Conditions: Prevention of Urinary Tract Infections in Children

Summary: the investigators aim to assess the effectiveness of prophylaxis of urinary tract infections in children with a probiotic containing lactobacillus rhamnosus pl1 and lactobacillus plantarum pm1. it is formulated a hypothesis that a 3-months course of probiotic prophylasis is more effective than placebo.

in previously published european and global guidelines, there has been no consensus among experts regarding the prophylaxis of recurrence urinary tract infections. depending on the recommendation, the prevention of recurrence uti should be used, not justified, or should be used in special cases. however, preparations that will be effective in preventing uti and will not cause bacterial resistance are still sought. 106 patients aged 3 to 18 years with recurrence utis (defined as: ≥2 infections in the upper urinary tract or 1 uti in the upper urinary tract and ≥1 in the lower urinary tract or ≥3 or more uti in the lower urinary tract in one year) or children with ≥1 infection in the upper urinary tract and ≥1 of recurrent utis risk factors (congenital anomalies of the kidney and urinary tract, constipation, bladder dysfunction, myelomeningocele, sexual activity in girls) will be randomly assigned to receive a 90-days prophylaxsis arm (probiotic urolact containing lactobacillus rhamnosus pl1 and lactobacillus plantarum pm1) or a 90-days placebo arms. the primary outcome measure will be frequencies of recurrence of uti during the 6 months after the intervention.

Eligibility criteria:
inclusion criteria: * recurrent utis (defined as: ≥2 infections in the upper urinary tract or 1 uti in the upper urinary tract and ≥1 in the lower urinary tract or ≥3 or more uti in the lower urinary tract in one year) or 1 infection in the upper urinary tract and ≥1 of recurrent utis risk factors: congenital anomalies of the kidney and urinary tract, constipation, bladder dysfunction, myelomeningocele, sexual activity in girls * ≥1 episode of urinary tract infection in the last 6 months exclusion criteria: * intake of probiotic preparations for ≥1 month in the last 3 months * known allergy to the study products * immunosuppression therapy * disease with immune deficiency * children with other coexisting infection, e.g. meningitis, sepsis, pneumonia, otitis

Keywords: urinary tract infection prophylaxis probiotics
ultrasound guided median nerve hydrodissection using dextrose

Conditions: Carpal Tunnel Syndrome

Summary: to compare the efficacy of dextrose 5% with steroid hydrodissection in patients with carpal tunnel syndrome

in some cases there is prohibition to use steroid with example the patient rejection to use steroid the maneuver planned median nerve hydrodissection using ultrasound and 10 mld of dextrose 5%, unleash the median nerve for the surrounding structure and short follow up planned to be 2 weeks

Eligibility criteria:
inclusion criteria: severe carpal tunnel syndrome failed medical management - exclusion criteria: previous failed surgery previous failed injection previous failed trial of hydrodissection cervical or brachial nerve entrapment wrist osteoarthritis or rheumatoid pregnant diabetes mellitus -
strength training and endurance exercise for life

Conditions: HIV

Summary: research is needed to determine safe and effective exercise rehabilitation programs to prevent and improve physical disability in older adults living with hiv. this problem is of great importance to the va. the majority of the 25 thousand hiv-infected veterans are over 50 years of age (64%). the combined effect of aging and inflammation increase the risk for physical disability in older hiv-infected veterans. this translational exercise training trial will examine the cardiac and skeletal muscle effects of combined aerobic exercise and resistance training to attenuate the functional declines of aging with hiv by reducing the deleterious consequences of chronic inflammation. findings will guide future rehabilitation research on cardiac remodeling and inflammation of skeletal muscle. the proposed research will advance the goal to develop effective rehabilitation strategies that improve the health of older hiv-infected veterans.

the objective of this study is to determine the effect of exercise training on the central (cardiovascular) and peripheral (muscular) impairments underlying poor physical function by comparing older hiv-infected veterans randomized to combine aerobic and resistance exercise training versus usual care. the study hypothesis is that a progressive aerobic and resistance rehabilitation program will increase aerobic capacity and muscle strength, which will be mediated by improved diastolic function, increased muscle mass, and decreased systemic inflammation. to test this hypothesis, investigators will conduct a randomized 16-week trial of progressive aerobic and resistance training versus usual care control in 40 sedentary older (50+ years) hiv-infected veterans. the study will determine the effects of exercise training on aerobic capacity and diastolic function, and their relationship to changes in biomarkers of systemic inflammation and cardiac fibrosis (aim 1). the study will also determine the effect of exercise training on strength and muscle mass, and their relationship to changes in biomarkers of systemic inflammation (aim 2).

Eligibility criteria:
inclusion criteria: * hiv-infected veterans adult 50 years of age and older under medical care for hiv * antiretroviral therapy exclusion criteria: * patients with comorbid conditions that could have a potential impact on their ability to perform exercise testing and training will be excluded according to the american college of sports medicine * only sedentary adults will be eligible. individuals that participate in regular structured aerobic exercise or resistance training in the prior 6-months will be excluded

Keywords: exercise aging aerobic capacity cardiac function inflammation
effects of chewing gum against postoperative ileus

Conditions: Pancreas Neoplasm

Summary: the purpose of this study is to determine whether the use of chewing gum effects postoperative ileus after pancreaticoduodenectomy

postoperative ileus is common after surgery. one non-pharmacological intervention that has shown promising results in reducing the duration of postoperative ileus is chewing gum after surgery. however, this has not been investigated in upper gastrointestinal surgery such as pancreatic surgery. hence the aim of this study was to investigate the effects of chewing gum treatment on patients undergoing pancreaticoduodenectomy due to pancreatic or periampullary cancer. this study was conducted as a phase-iii trial. patients diagnosed with pancreatic tumours scheduled for pancreaticoduodenectomy were included. the treatment group received chewing gum postoperatively and standard care. controls received glucose solution and standard care.

Eligibility criteria:
inclusion criteria: 1. pancreatic or periampullary cancer and scheduled to undergo pancreaticoduodenectomy. exclusion criteria: * 2. ongoing treatment for mental disease 3. diagnosed neurological injuries or diseases affecting the ability to swallow or gastric function 4. ongoing abuse of alcohol or other drugs 5. previously known allergies to the content of chewing gum 6. additional surgery after primary surgery.
testing financial incentive interventions in dyadic-smoker couples

Conditions: Nicotine Dependence

Summary: the proposed study investigates the feasibility and efficacy of fits in dual-smoker couples \[dscs\]. the core design is a three-group mixed repeated measures design, in which participants are randomized into one of three conditions (control \[ctl\], dyadic target \[dt\] fit or single target \[st\] fit) and tracked across 3 months. the fit involves monetary incentives for online psychoeducation completion and smoking abstinence at follow-up.

the proposed study investigates the feasibility and efficacy of fits in dual-smoker couples \[dscs\]. the core design is a three-group mixed repeated measures design, in which participants are randomized into one of three conditions (control \[ctl\], dyadic target \[dt\] fit or single target \[st\] fit) and tracked across 3 months. during this time, participants will complete a baseline session and a follow-up. between these visits, all participants will have access to a voluntary brief cessation program (i.e., online psychoeducation created for this study using beat the pack materials and resources from nci, nih + nicotine replacement therapy \[nrt\]). the fit involves monetary incentives for online psychoeducation completion and smoking abstinence at follow-up. in the st condition, one member of each couple (i.e., the target) will receive monetary incentives; in the dt condition, both members of the couple will receive monetary incentives. this design allows for preliminary consideration of fits in dscs and tests whether fits for both members of the dyad synergistically enhances outcomes.

Eligibility criteria:
inclusion criteria: both members: * age of 18+ * smoke 5+ combustible cigarettes/day * may not have participated in pilot study exclusion criteria: * \< 8th grade capacity to read/write in english * hospitalization in recent 6 months * current drug or alcohol use disorder * psychotic symptoms * medical exclusion for use of nrt
study to assess safety and tolerability of azd4547 in japanese patient

Conditions: Cancer; Advanced Solid Malignancies

Summary: the primary purpose of this study is to explore the safety and tolerability of azd4547 in japanese patients with advanced solid malignancies.

a phase i, open-label, multicentre study to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumour activity of ascending doses of azd4547 in japanese patients with advanced solid malignancies.

Eligibility criteria:
inclusion criteria: - japanese patients with advanced solid malignancies over 25 years old relatively good overall health other than cancer exclusion criteria: - poor bone marrow function (not producing enough blood cells). poor liver or kidney function. refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the ip or previous significant bowel resection.

Keywords: phase i cancer solid tumours advanced solid malignancies dose escalation fgfr tki japanese
the effect of glycyrrhizin on the occurrence of postoperative nausea and vomiting

Conditions: Postoperative Nausea

Summary: the investigators investigate the association between the administration of glycyrrhizin during induction of general anesthesia and the occurrence of postoperative nausea and vomiting (ponv) in patients undergo breast surgery

postoperative nausea and vomiting (ponv) is one of a common complication after general anesthesia with 30-50% of incidence, increased up to 80% in high risk group. the risk factors of ponv include women population, the previous history of ponv, motion sickness in usual life, non-smoker, exposure to inhalants, perioperative opioid and laparoscopic surgery. women population is a strong risk factor of ponv. although perioperative management of ponv based on a guideline has been done in a lot of medical centers worldwide, the incidence of ponv is still reported relatively high. the main ingredient of glycyrrhizin is liquorice which has been used as antispasmodics, antiemetics or treatment for gastric ulcer in oriental medicine. utilizing these effects of liquorice, the investigators investigate whether the addition of glycyrrhzin to conventional antiemetics is effective to decrease the incidence of ponv and improvement of severity of ponv.

Eligibility criteria:
inclusion criteria: * participants scheduled to undergo breast surgery aged 20 and above exclusion criteria: * aldosteronism * electrolyte imbalance * myopathies * drug addiction or suspected * bowel disease * allergy to drugs * smoker * taking any medications
alcohol biosensor monitoring for alcoholic liver disease

Conditions: Alcohol Use, Unspecified

Summary: successful treatment of alcohol associated liver disease (aald) depends primarily on abstinence from alcohol. the investigators propose a randomized clinical trial of alcohol biosensor monitoring for patients with alcohol associated liver disease to determine if monitoring with feedback on alcohol use patterns reduces alcohol consumption and improves outcomes.

the investigators propose a 3 month randomized controlled trial (rct) pilot of alcohol biosensor monitoring (abm)(wristas) for patients with alcohol associated liver disease (aald) who intend to stop drinking. all participants will wear the abm device but participants will be randomized to receive either personalized feedback on the data recorded on the device (n=30) or enhanced usual care without feedback on device data (n=30). the investigators will determine whether abm plus feedback improves outcomes for aald patients compared to enhanced usual care and hypothesize abm feedback will reduce alcohol consumption, improve motivation and self-efficacy for abstinence and improve engagement in treatment. the investigators will also conduct research including qualitative data collected from participants who will provide opinions on abm feasibility, acceptability, and usability. qualitative methods are especially useful for understanding the perceived needs, barriers, and preferences for monitoring alcohol use and are especially required for future translation of this technology into clinical practice.

Eligibility criteria:
inclusion criteria: * patients with aald followed at our liver disease clinic, * 18 years or older, * willing to accept randomization, * and agree to wear device for 3 months, * socrates problem recognition subscale score \>26 (scores \<26 indicate very low recognition of an alcohol problem). exclusion criteria: * non-english speaking, * montreal cognitive assessment (moca) scores \<21 (moderate cognitive impairment) or neurologic diseases (e.g. parkinson's), * patients with unresponsive acute alcoholic hepatitis, multi-organ failure, fulminant hepatic failure, * cancer/terminal illness; * those unable to wear a wrist monitor (e.g., edema); * lacking a residence, or unable to identify a contact person (if lost to follow-up).
brief chemoimmunotherapy with r+b+m followed by r in elderly patients advanced stage untreated follicular lymphoma

Conditions: Follicular Lymphoma

Summary: this is a prospective, multicenter phase ii trial designed to determine efficacy and safety of a brief chemoimmunotherapy with the combination of rituximab + bendamustine + mitoxantrone in elderly patients with advanced stage follicular lymphoma.


Eligibility criteria:
inclusion criteria: * histological proven diagnosis of b-cell cd20+ follicular nhl, grade i, ii and iiia of who classification * untreated patients with the exception of prior limited radiotherapy * stage iii or iv who require therapy according to sie and gelf criteria * stage ii with at least one of the following: * bulky disease (\>7 cm) * ldh \>normal * systemic symptoms * beta2-microglobulin \>3 mg/l * extra-nodal involvement * active disease with rapid progression 5.age from 65 to 80 years, geriatric score "fit" (see appendix b) 6.life expectancy \>6 months 7.ecog performance status 0-2 (see appendix c) 8.lvef ≥45% or fs ≥37% 9.anc ≥1 x 109/l and platelets count ≥75 x 109/l, unless due to bone marrow involvement by follicular lymphoma 10.creatinine up to 1.5 x uln 11.conjugated bilirubin up to 2 x uln 12.alkaline phosphatase and transaminases up to 2 x uln 13.sending of bone marrow sample for bcl-2/igh rearrangement evaluation 14.written informed content exclusion criteria: * men not agreeing to take adequate contraceptive precautions during and for at least 6 months after cessation of therapy * history of other malignancies within 3 years prior to study entry except for: adequately treated carcinoma in situ of the cervix; basal or squamous cell skin cancer; low grade, early stage, localized prostate cancer treated surgically with curative intent; good prognosis dcis of the breast treated with lumpectomy alone with curative intent * medical condition requiring long term use (\>1 months) of systemic corticosteroids * active bacterial, viral, or fungal infection requiring systemic therapy 5. concurrent medical condition which might exclude administration of therapy * cardiac insufficiency (nyha grade iii/iv; see appendix d) * myocardial infarction within 6 months of entry on study * severe chronic obstructive pulmonary disease with hypoxemia * severe diabetes mellitus difficult to control with adequate insulin therapy * hypertension that is difficult to control * impaired renal function with creatinine clearance \<30 ml/min (see appendix e) * hiv positivity * hbv positivity with the exception of patients hbsag negative and ab anti-hbcore positive (these patients need to receive prophylaxis with lamivudine) * hcv positivity with the exception of patients with no laboratory signs of active chronic hepatitis and hcv-rna negativity * cns involvement by lymphoma 16. participation at the same time in another study in which investigational drugs are used * known hypersensitivity or anaphylactic reactions to murine antibodies or proteins * any other co-existing medical or psychological condition that would preclude participation in the study or compromise ability to give informed consent