Kornimate/medical-research-clean huggingface dataset:
breakfast and muscle health in children

Conditions: Body Weight Changes; Body Composition; Muscle Mass; Energy Expenditure; Nutrition

Summary: one in every three children ages 2-19 years is overweight or obese. although multifactorial in nature, obesity is primarily attributed to a mismatch between energy intake and energy expenditure (ee). daily ee (dee) can be partitioned between resting metabolic rate (rmr), ee associated with physical activity, and the thermic effect of food (tef). rmr corresponds to the energy needed to sustain the body functions at rest and is also related to body composition (i.e., ratio of skeletal muscle mass to fat mass). skeletal muscle mass is a large contributor to rmr; the more skeletal muscle mass, the higher the rmr (i.e., more energy expended at rest). in addition, muscle plays a central role in whole body protein metabolism and disrupted muscle metabolism is associated with the development of many common chronic diseases associated with obesity such as type 2 diabetes and cardiovascular disease. although the contribution of disrupted muscle metabolism to chronic disease is well-established in older adults, the potential impact in children is unknown. the overall objective for this primary project application is to determine the role of breakfast protein consumption in improving energy metabolism, energy balance and skeletal muscle health in obese, school-aged children.


Eligibility criteria:
inclusion criteria: * resides within northwest arkansas * age 8-12 years old * bmi \>5th percentile * all ethnicities exclusion criteria: * food allergies * dietary restrictions * regularly skip breakfast (\> 5 times per week) * prescription medications * claustrophobic * fear of needles * classified as a picky eater by parent/guardian
an observational study of environmental and socioeconomic factors in opioid recovery - long term

Conditions: Opioid Use Disorder

Summary: the purpose of this study (recover-lt) is to better understand the long-term paths of recovery from opioid use disorder (oud) for an additional 5 year period after the original recover (nct03604861) study. long-term patterns of abstinence/opioid misuse as well as measures of participants' physical, psychological, social and economic well being will be monitored in order to identify factors associated with recovery from oud.


Eligibility criteria:
inclusion criteria: * individuals who enrolled in the recover study * ability to comply with current study protocol requirements for data collection * provide informed consent exclusion criteria: * minors will not be included * prisoners will not be included. if participants become incarcerated during this study, they will not be contacted to complete assessments during their incarceration. if the incarceration ends during the study, they may be contacted to participate in assessments * adults who are not capable of consenting on their own behalf
study of icg fluorescence imaging in open fracture and infection patients

Conditions: Fractures, Bone; Trauma Injury

Summary: the purpose of this study is to determine whether an indocyanine green (icg) fluorescence imaging system (cbpi) can be used to provide surgeons with information about bone health or bone blood flow. this will help surgeons better understand the healing potential of bone and relative risk of complication. this is important to help surgeons select the most appropriate treatment for severe traumatic injuries and infections.


Eligibility criteria:
inclusion criteria: * patients 18 years of age or older. * open extremity fracture, planning for management with external fixation, internal fixation or joint fusion. * fracture related infection, planning for management with debridement and possible removal of hardware. * will have all planned fracture care surgeries performed by a participating surgeon or delegate. * provision of informed consent. exclusion criteria: * inability of patient to provide informed consent * fracture of the hand. * iodine allergy. * burns at the fracture site.

Keywords: immunofluorescence orthopaedic trauma infection
gynecologic cancer lymphedema questionnaire as a clinical care tool to identify lower extremity lymphedema

Conditions: Ovarian Cancer; Uterine Cancer; Vaginal Cancer; Lymphedema

Summary: the purpose of this study is to evaluate if the gynecologic cancer lymphedema questionnaire (gclq) truly detects symptoms or signs of lower extremity lymphedema in patients with diagnosed lower extremity lymphedema. lymphedema is a chronic condition in which fluid accumulates in the tissues of the body. many cancer survivors are living with discomfort and changes in their activities due to limb swelling following cancer treatment. if the gclq is able to do detect signs and symptoms of lymphedema, the investigators hope to use it as a tool in the clinical care setting to help identify women at risk for or with lymphedema. in the future, this could improve clinical care through the use of a more simple and feasible way to identify lower extremity lymphedema than measuring limbs.


Eligibility criteria:
inclusion criteria: * study group of gynecologic cancer survivors with lymphedema * documented lower extremity lymphedema * history of a primary diagnosis of gynecologic cancer (vulvar, cervical and uterine only) * history of surgery for gynecologic cancer including lymph node removal * no evidence of disease or active treatment * at least 21 years of age * able and willing to provide informed consent * english fluency comparison group of gynecologic cancer survivors without lymphedema * no history of lower extremity lymphedema or presence of lymphedema confirmed by limb volume measurements at the time of study participation * history of a primary diagnosis of gynecologic cancer (vulvar, cervical and uterine only) * history of surgery for gynecologic cancer including lymph node removal * no evidence of disease or active treatment * at least 21 years of age * able and willing to provide informed consent * english fluency exclusion criteria: * inability to participate in an informed consent process * patients with a psychiatric disorder precluding response to the survey

Keywords: corpus uteri, endometrium fallopian tube ovary vagina lymphedema questionnaire quality of life 09-077 fallopian tubes
effect of mediterranean and hypolipemic reduction diet in obese patients

Conditions: Obesity

Summary: the purpose of this study is to evaluate the combined effect of physical activity and adherence to mediterranean diet or hypolipemic reduction diet on parameters of oxidative stress in obese patients enrolled in the weight management reduction program.


Eligibility criteria:
inclusion criteria: * bmi ≥ 30 kg/m2 exclusion criteria: * newly diagnosed diabetes, hypertension or cardiovascular disease * change in antihypertensive therapy and antidiabetic therapy in the period of 3 months prior to the commencement of the study * insulin therapy * alcohol consumption \>500 g of alcohol/week in the last year * pregnancy or breast feeding * use of drugs affecting weight control (eg. weight loss medication or systemic glucocorticoids)
massive burns: retrospective analysis of changes in outcomes across 18 years

Conditions: Burns

Summary: burns treatment and management has evolved since the 90s, particularly for massive burns (≥ 50% of total body surface area (tbsa)). this study aims at analyzing the impact of the management changes on the length of intensive care unit (icu) stay, the take of skin grafts and the mortality.

review of all massively burned patients treated at lausanne university hospital burn intensive care unit (ca. 40-60 patients). analysis of changes in length of intensive care unit stay (licu), skin graft take rate or mortality between 2000 and 2018. hypothesis : the optimization of resuscitation procedures and of nutrition therapy combined with the use of novel surgical techniques has brought a significant improvement in outcomes. association between outcomes and year of admission will be assessed through correlation analysis and logistic regression analysis. potential cofounders will be assessed through stepwise linear regression analysis

Eligibility criteria:
inclusion criteria: * all adult patients (\>18 years old) with burns ≥50% tbsa admitted in the burn intensive care unit (icu) of the lausanne university hospital exclusion criteria: * patients admitted in the burn center icu with another primary diagnosis than burn (e.g. necrotizing fasciitis, gangrene, toxic epidermal necrolysis) * patients referred from and/or to another icu * patients in which active withdrawal of care was decided within 48h of admission * patients with first degree burns only

Keywords: massive burns intensive care unit burn surgery burn infections skin grafts critical illness cultured epithelial autografts nutrition glucose
influence of manual diaphragm release on pulmonary functions in women with covid-19

Conditions: COVID-19 Pneumonia

Summary: manual noninvasive respiratory techniques gained interest to treat respiratory pathologies related to covid 19. this study designed to determine the combined effect of manual diaphragmatic release technique with the effect of conventional breathing exercises and prone positioning on pulmonary function parameters (fvc, fev1, pef, fev1/fvc, fef25, fef50, fef75, fef25/75).

forty females were randomly assigned to two groups. group a received manual diaphragm release with conventional breathing exercises and prone positioning. group b received conventional breathing exercises and prone positioning. both groups took their prescribed medications. their ages ranged from 35 to 45 years and with moderate covid-19 illness. any cases with mild and severe covid-19 illness, icu admission, and chest diseases were excluded. main measures: pulmonary function parameters (fvc, fev1, pef, fev1/fvc, fef25, fef50, fef75, fef25/75).

Eligibility criteria:
inclusion criteria: * women with moderate covid-19 illness diagnosed by a physician. * patients with o2 saturation \>94%nonsmoker subjects. * age ranging from 35-45 years. * body mass index from 25 to 34 kg/m2. exclusion criteria: * unstable hemodynamic status. * acute respiratory failure requiring intubation and impaired consciousness. * inability to collaborate with prone positioning with refusal. * change of mental status hindering response to instructions. * poorly controlled hypertension (mean systolic bp \> 140 mmhg and \\or diastolic bp \> 40 mmhg). * patients who take continuous o2 supplementation. * smoking. * other chest diseases as (copd-asthma-tuberculosis-cancer). * male patients.

Keywords: breathing exercise covid-19 manual diaphragmatic release pulmonary function parameters
comparative study between two models of a non-invasive glucose monitoring device

Conditions: Type1diabetes

Summary: this clinical study has been launched to compare the performances of two models of a non-invasive glucose monitoring device.

subjects will be optical screened at baseline visit. study comprises two in-clinic visits. subjects will arrive in a fasting state and and oral glucose bolus will be administered. subjects will during each of two study days be subjected to optical readings on two different device prototypes. during each of the study days, fgm readings, capillary blood samples and arterialized venous blood samples will be collected.

Eligibility criteria:
inclusion criteria: * male and female subjects 18 years of age or older * diabetic type 1 patients * insulin pump users * skin phototype 1-4 exclusion criteria: * for female participants: pregnancy or subject is attempting to conceive or not willing and able to practice birth control during the study duration * for female participants: breastfeeding * subjects not able to understand and read danish * in investigator's opinion, subject is not able to follow instructions as specified in the protocol * rejection by optical screenings * subjects not able to hold hand/arm steadily (including tremors and parkinson's disease) * diagnosed with reduced circulation * extensive skin changes, tattoos or diseases on probe application site * known allergy to medical grade alcohol * known allergy to adhesives * systemic or topical administration of glucocorticoids for the past 7 days * subjects undergoing dialysis treatment * medical history or any condition that may, in the opinion of the investigator, compromise the subject's ability to participate * concomitant medical condition which could present a risk to the safety or welfare of the subject or study staff * subjects currently enrolled in another study

Keywords: non-invasive glucose monitoring
reading stories to premature babies reinforces mother-baby synchronies?

Conditions: Premature Infant; Mother-Baby Synchrony

Summary: observations of the early interactions between the infant and his parents highlighted the existence of rhythmic and reciprocal communications that serve as a basis for the mother-baby relationship and the emotional and cognitive development of the baby.

observations of the early interactions between the infant and his parents highlighted the existence of rhythmic and reciprocal communications that serve as a basis for the mother-baby relationship and the emotional and cognitive development of the baby. in this study, the investigator proposes to focus on premature births (before 37 years) because prematurity disrupts the synchronization of these mother-baby communication. for several years, reading of stories and nursery rhymes has been used by the liaison child psychiatry team in the neonatal medicine and pediatric intensive care unit of the university hospital of amiens, as a therapeutic mediation tool allowing and support for parent-child interactions. thus, it is desirable to explore the impact of reading stories and rhymes on mother-baby synchronies. the study is innovative because it simultaneously explores several fields: physiological, neuroendocrine, cognitive and psychic. a pilot study carried out in 2013 showed the feasibility of this exploration in the three protagonists of the interaction: mother, preterm baby and reader.

Eligibility criteria:
inclusion criteria: * a premature birth between 27 and 37 sa * at the time of the transfers, the latter must be hospitalized in intensive care and extubated exclusion criteria: for the baby: * an unstable medical condition * serious somatic complications * genetic or neurological diseases * a twin. for the mother: * an impossibility to understand and speak the french language * a mental or cognitive pathology * an addiction to alcohol or other psychoactive substances * persons under guardianship or curatorship or deprived of their liberty by a judicial or administrative decision
study of the use of venetoclax in participants with chronic lymphocytic leukemia (cll) under real-life setting

Conditions: Chronic Lymphocytic Leukemia (CLL)

Summary: an observational study to assess the effectiveness, health economic-relevant costs and participant reported outcomes in participants with chronic lymphocytic leukemia (cll) receiving venetoclax as a monotherapy or in combination with rituximab or obinutuzumab as prescribed at the discretion of the physician and in accordance with local clinical practice and label.


Eligibility criteria:
inclusion criteria: * participant with chronic lymphocytic leukemia (cll) administering venetoclax and who meets the following conditions as specified in the label for venetoclax: * venetoclax monotherapy for the treatment of cll in the presence of deletion chromosome 17 (del\[17p\]) or tumor protein p53 (tp53) mutation in adult participants, who are unsuitable for or have failed to a b-cell receptor pathway inhibitor. * venetoclax monotherapy for the treatment of cll in the absence of del(17p) or tp53 mutation in adult participants, who have failed both chemoimmunotherapy and a b-cell receptor pathway inhibitor. * venetoclax in combination with rituximab for the treatment of adult participants with cll who have received at least one prior therapy. * venetoclax in combination with obinutuzumab for previously untreated adult participants with cll. exclusion criteria: - none

Keywords: chronic lymphocytic leukemia (cll) cancer leukemia venetoclax rituximab obinutuzumab abt-199 venclexta venclyxto
effectiveness of a person-centred prescription model at the end of life

Conditions: End-Of-Life; Inappropriate Prescribing; Deprescriptions; Palliative Medicine; Geriatrics

Summary: this study's main objective is to investigate whether the application of an adapted person-centred prescription model during a hospital stay would reduce the use of inappropriate or futile regular medications in older people at the end of life, improving their clinical/health statuses and reducing the expense associated with pharmacological treatment. we hypothesised that applying this modified method could optimise pharmacotherapeutic indicators and the expense associated with the pharmacological treatment of hospitalised patients


Eligibility criteria:
inclusion criteria: * patients admitted to the geriatric convalescence unit and identified as having a non-oncological advanced chronic disease and being in need of palliative care, with a limited survival prognosis according to the necessity of palliative care (necpal) test. exclusion criteria: * patients with hospital stays of less than 72 hours. * patients transferred to other hospitals or units. * patients with imminently terminal patients.
navigator guided e-psychoeducational intervention

Conditions: Prostate Cancer

Summary: the purpose of this study is to evaluate the impact of providing newly diagnosed prostate cancer patients and their caregivers with an interactive mobile tablet technology-based application delivered by a community navigator versus providing national cancer institute (nci) information booklets delivered by a community navigator (cn) on patient outcomes (decisional satisfaction, quality of life, knowledge, decisional conflict) and shared decision making practices (decision making involvement).


Eligibility criteria:
inclusion criteria: * men newly diagnosed (within 6 months) with biopsy confirmed case of prostate cancer * 40 - 80 years of age * able to speak and read english * live within 120 miles of a healthcare treatment facility * have no documented or observable visual, auditory, psychiatric, or neurological disorders that would interfere with study participation * be able to complete telephone interviews * have not completed the first course of treatment * have a family member/caregiver willing to participate * capable of providing written consent for study participation. men diagnosed with early stage, locally advanced or metastatic disease or men who are on active surveillance will be eligible to participate in this study. * caregiver must be aged 18 or older * caregiver must be identified by patient as their caregiver (i.e., provider of emotional and/or physical care) * caregiver must have not been diagnosed with cancer in the previous year or be receiving cancer treatment

Keywords: newly diagnosed prostate cancer prostate
an observational study on the prevalence of chronic hepatitis d in romania and the efficacy of treatment with pegasys (peginterferon alfa-2a)

Conditions: Hepatitis D, Chronic

Summary: this prospective, multicenter, observational study will assess the prevalence of chronic hepatitis d in patients with chronic hepatitis b in romania and evaluate the efficacy of pegasys (peginterferon alfa-2a) in patients with chronic hepatitis d. eligible patients treated with pegasys according to current medical practice will be followed until 24 weeks after the end of treatment.


Eligibility criteria:
inclusion criteria: for epidemiological part of the study: * adult patients \>/= 18 years of age * positive hbsag for at least 6 months for the non-interventional section of the study * adult patients, \>/= 18 years of age * positive hbsag for at least 6 months * positive anti-delta and positive hdv rna by pcr * elevated serum alt \>/= 2x uln exclusion criteria: patients with any of the following will not be eligible for treatment with pegasys: * history of neurological disease * history of severe psychiatric disease * decompensated diabetes * history of immunologically mediated disease * history of severe cardiac disease * history or other evidence of severe chronic pulmonary disease * inadequate hematologic function
clinic features and outcome of bpd (sgbpd)

Conditions: Bronchopulmonary Dysplasia

Summary: this study described the perinatal high-risk factors and clinical manifestations of the children, and compared the high-risk factors, clinical manifestations and prognosis of bpd among different clinical subtypes by comparison between groups. bpd grading was performed using the 2018 grading standard to compare the distribution of i/ii/iii bpd among different groups.


Eligibility criteria:
inclusion criteria: 1. premature infants born at \<32 weeks of gestational age; 2. hospitalization time ≥ 14 days; 3. the clinical medical records are complete exclusion criteria: * • 1) children with congenital heart, lung malformation and definite chromosomal diseases; 2) children gave up treatment halfway; 3) corrected gestational age 36 weeks before death, the cause of death was confirmed as factors other than respiratory system.
evaluation of the association between right atrial reservoir strain variation and fluid responsiveness in patients with septic shock

Conditions: Fluid Responsivness; Right Ventricle

Summary: evaluating preload dependence is crucial for managing fluid administration in septic shock patients. to avoid unnecessary fluid administration, it's recommended to use dynamic tests like the passive leg raising (plr) maneuver or a fluid challenge (fc) to see if a patient's cardiac output will increase after fluid resuscitation. transthoracic echocardiography (tte) is preferred for this because it can non-invasively, reliably, and reproducibly measure the increase in cardiac output. a patient is considered a "responder" if their stroke volume (sv) increases by more than 15% after an fc. two-dimensional (2d) right atrial strain (ras) is a promising tool for evaluating right atrial function. according to the frank-starling law, measuring changes in the ra reservoir strain phase (rasr) can identify acute changes in preload, like those induced by a plr maneuver or an fc. the aims of this study are to assess the ability of ∆rasr to identify responders after a fluid challenge (fc) and to evaluate the ability of ∆rasr variation induced by a plr maneuver to distinguish responders from non-responders to volume expansion.


Eligibility criteria:
inclusion criteria: * adult patient (\>18 years old) * patient hospitalized in the intensive care unit at amiens university hospital with septic shock for less than 48 hours, defined by the presence of all the following criteria: presence of sepsis, hypotension requiring vasopressors to maintain a mean arterial pressure ≥ 65 mmhg despite adequate prior fluid resuscitation, and blood lactate levels \> 2 mmol/l (18 mg/dl). * patient requiring fluid resuscitation with crystalloids/colloids * patient on invasive mechanical ventilation in assisted-controlled mode. * blood pressure monitored via a radial or femoral arterial catheter connected to a mostcareup (vygon, france). * patient or family informed and non-opposition documented. exclusion criteria: * poor echocardiographic image quality preventing rasr assessment * patient with a contraindication to the plr maneuver: severe head trauma or intracranial hypertension * patient with a history of pericardiectomy * patient with a clinical examination consistent with abdominal compartment syndrome * patient with aortic pathology, mitral regurgitation greater than grade 2, tricuspid regurgitation greater than grade 2, mitral stenosis, or intracardiac shunt * patient with internal or external atrial/ventricular pacing * pregnant woman * patient on extracorporeal membrane oxygenation and mechanical circulatory support * moribund patient * patient with supraventricular or ventricular arrhythmia during echocardiographic measurement series * patient on renal replacement therapy during echocardiographic examination

Keywords: right atrial strain fluid responsivness preload right ventricle