Kornimate/medical-research-clean huggingface dataset:
efficacy of liposomal bupivacaine versus 0.25% bupivacaine for laparoscopic urologic surgery

Conditions: Pain, Postoperative

Summary: a prospective, randomized comparison of bupivacaine to liposomal bupivacaine given by local injection at all the wound sites in patients undergoing robotic-assisted or laparoscopic urologic surgeries in an effort to determine which method reduced postoperative opioid use the most.

liposomal bupivacaine was developed to extend the duration of efficacy of bupivacaine from the typical 6 - 8 hours up to 72 hours. the prolonged duration of liposomal bupivacaine was initially demonstrated in mice in 1994. two randomized controlled trials using liposomal bupivacaine for bunionectomy and hemorrhoidectomy resulted in fda approval for its use in humans. more recently, liposomal bupivacaine has also been found to improve pain control for patients undergoing total knee arthroplasty. infiltration of a local anesthetic into laparoscopic port sites is a common practice that has been shown in some studies to improve postoperative pain. to compare liposomal bupivacaine and 0.25% bupivacaine for local analgesia following laparoscopic and robotic urologic surgery, a randomized comparison-controlled trial was performed.

Eligibility criteria:
inclusion criteria: * at least 18-years-old, undergoing laparoscopic urologic surgery. exclusion criteria: * pregnant and/or nursing mothers. * allergy to bupivacaine.

Keywords: randomized controlled trial anesthetics-local bupivacaine analgesia pain, postoperative
an observational study on post-chronic pancreatitis diabetes mellitus

Conditions: Chronic Pancreatitis; Diabetes Mellitus

Summary: to explore the risk factors influencing glycemic status, optimized treatment, and prognosis of post-chronic pancreatitis diabetes mellitus (ppdm-c).

the present study was an observational study aimed to explore risk factors influencing glycemic status, optimized treatment, and prognosis of post-chronic pancreatitis diabetes mellitus. the observation items included clinical characteristics, blood glucose control and incidence of complications of ppdm-c.

Eligibility criteria:
inclusion criteria: 1. patients with diagnosis of chronic pancreatitis and diabetes mellitus. 2. participants with painless chronic pancreatitis were diagnosed with diabetes within 2 years of the diagnosis of chronic pancreatitis. 3. participants with painful chronic pancreatitis were diagnosed with diabetes after the first attack of chronic pancreatitis. exclusion criteria: 1. participants with suspected malignant tumors of the pancreas or other sites of body, or participants in the terminal stage of severe disease 2. serious mental illness, lesion of liver or kidney, pregnancy, breast-feeding or planning pregnancy 3. definitely diagnosed type 1 diabetes, type 2 diabetes, or other metabolic diseases that affect blood glucose 4. autoimmune pancreatitis 5. scarcity of information related to hba1c 6. death or loss of follow-up during follow-up
quantification of endothelial thrombogenicity in patients with atrial fibrillation

Conditions: Atrial Fibrillation

Summary: atrial fibrillation (af) is the most common cardiac arrhythmia. because of its major impact on the general morbidity and risk of stroke, af is a great concern for public health. several mechanisms, including endothelial dysfunction and inflammatory processes, have been postulated as predisposing factors for af, as well as for stroke. both clinical and experimental studies highlight inflammation as a predisposing factor for af and its complications. nevertheless, the source of high inflammatory proteins in patients with af is still unknown. we hypothesized that multilevel intracardiac and extracardiac (left femoral vein, coronary sinus, left atrium, pulmonary vein) measurements of several inflammatory proteins (vegf) would help assessing the extent and the source of inflammation in af patients. the measurement of von willebrand factor (vwf) levels in multiple vascular sites would also help to define the site of endothelial dysfunction and of production of this thrombogenic factor. although af is associated with an increased risk of stroke, the risk is not homogeneous. permanent and persistent af are associated with similar thromboembolic risk to that of paroxysmal af.


Eligibility criteria:
inclusion criteria: * patient for which an electrophysiology exploration or ablation is programmed; * patient who have given written informed consent. exclusion criteria: * pregnant women; * lung disease history (all sources); * inflammatory disease history (all types); * anti-inflammatory treatment; * left ventricular ejection fraction \<35%; * history of stroke; * participation in other ongoing clinical trial.

Keywords: atrial fibrillation stroke thromboembolism inflammation
effect of low level laser therapy on hamstring muscle tightness and calf muscle spasticity in cerebral palsy children.

Conditions: Cerebral Palsy

Summary: background :spasticity is a motor disorder in children with cerebral palsy (cp) cp is a non progress lesion in unmature brain lead to a group of chronic disorders that affect movement and posture development, may be accompanied by epilepsy, secondary musculoskeletal problems, deformaties and disturbances of sensation, perception, cognition, communication, and behavior few studies demonstrate effectiveness of laser therapies in spasticity in cp. methodology : this study is randomize control trail aimes to evaluate the effect of low-level laser therapy (lllt) on the spasticity of hamstring and calf muscle in children with cp over 12 session of intermittent laser exposures. muscle tone , gross motor function, rang of motion (rom ) and poplital angle will evaluate before and after laser irradiation in 30 children with cp both geneder aged between two to six years old diaplegic clidren , exclusion children who take botox or done surgery . muscles will irradiated with low-intensity diode laser pulses of 808-nm wavelength three times per week over one month follow up for one month.

this is a randomized controlled study, in which the 30 children with diaplegic randomly divide into control and study groups by excel sheat on computer, each group include 15child. each child will receive laser at a frequency of three sessions per week for 12 session, in addition to conventional physiotherapy program, while the control group have 15 child will receive conventional physiotherapy. four variables will choose to detect the effect of laser therapy: (1) muscle tone, (2) range of motion (rom) , (3) gross movement,(4) poplital angle assessment . these values will recorde in both groups before starting treatment and after the treatment period and after one month of stop treatment . .

Eligibility criteria:
inclusion criteria: * spastic diaplegic children aged between 2 to 6years have spastic hamstring and calf muscle . exclusion criteria: * for post-operative children , children who take botox, children with contracture or fixed deformity

Keywords: low level laser spasticity cerebral palsy
pillow use during total hip arthroplasty

Conditions: Arthroplasty, Replacement, Hip; Hip Replacement, Total

Summary: the purpose of this study is to find out whether placing a pillow between the legs during hip surgery will result in a better aligned hip replacement.

during hip replacement surgery the cup is placed on specific planned angles. cup placement has an effect on the patients' pain-free range of movement, dislocation rates and satisfaction. however, the angles of the cup orientation (i.e. the tilt and rotation), which are preoperatively planned and postoperatively measured on radiographs, have a high variability even when an experienced surgeon is performing the surgery. one of the reasons this occurs is because the operated leg can move the pelvis to a different position in the time between set-up and actual implantation which may lead to the cup being placed in a non-optimal position. this study aims to see if the difference between planned and achieved cup angles and pelvic movement can be lessened by putting a pillow in between the legs to keep it in a stable horizontal position.

Eligibility criteria:
inclusion criteria: * patient awaiting primary total hip arthroplasty using a posterior approach in a lateral decubitus position * patients capable of reading, understanding, and willing to sign the informed consent form exclusion criteria: * total hip arthroplasty not using a posterior approach in a lateral decubitus position * prior hip osteotomy or fracture osteosynthesis on the index hip
epidemiology of chronic bronchitis in patients with chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease; Chronic Bronchitis

Summary: the purpose of this study was to investigate the prevalence of chronic bronchitis in patients suffering from moderate to very severe chronic obstructive pulmonary disease (copd), and to assess the difference in exacerbation rates in patients suffering from moderate to very severe copd with chronic bronchitis vs. a population of patients without chronic bronchitis.

this was an observational study so participants only took medication that was prescribed by their regular healthcare provider. no additional study medication was administered. this study enrolled patients who were previously diagnosed with moderate to very severe chronic obstructive pulmonary disease (copd). this study looked at the prevalence of chronic bronchitis in patients suffering from moderate, severe or very severe copd, and it also compared worsening of copd in patients with or without chronic bronchitis. this study enrolled 976 patients. this multi-centre trial was conducted in belgium and luxembourg. the overall time to participate in this study was at a single, regularly scheduled visit at the pulmonologists office. there were no follow-up assessments for this study.

Eligibility criteria:
inclusion criteria: * 1. written informed consent. 2. age ≥ 40 years. 3. forced expiratory volume in one second (fev1)/forced vital capacity (fvc) ratio (post-bronchodilator) \<70%. 4. fev1 (post-bronchodilator) \< 80% of predicted. exclusion criteria: * 1. moderate and severe exacerbations during the last 4 weeks. 2. pregnancy. 3. already participated in the study (allowed to participate only once).

Keywords: copd
accuracy of full arch intraoral scanning

Conditions: Completely Edentulous

Summary: although an intraoral scanner ios can offer the clinician a completely digital workflow, achieving trustworthy digital scans in edentulous jaws is challenging because of the lack of fixed anatomical landmarks. from this perspective, several methods have been proposed to improve the accuracy of digital scanning, however, related results remain inconclusive, and previously proposed devices have had limitations, such as bulkiness, excessive manufacturing requirements, and poor commercial applicability. thus, this study aims to clinically compare the effect of conventional versus photogrammetry intraoral scanning methods on the passive fit of mandibular all-on four screw-retained frameworks.

the current study will be designed to be a crossover, double-blinded randomized clinical trial. eighteen edentulous patients will be selected to share in the study to be rehabilitated by screw-retained prostheses following the all-on-4 protocol. after guided implant surgery, patients will be immediately restored by screw-retained acrylic provisionals following the traditional denture conversion technique. the definitive prosthesis will be fabricated after osseointegration starting with the intraoral scanning procedure; each patient will be subjected to three different scanning methods that can enhance the existing ios workflow; for group i, the medit i600 will be used to obtain direct intraoral scans while the scan bodies are combined with extra photogrammetry system scanning assistance, for group ii, medit i600 direct intraoral scans will be obtained while applying basic simple splinting along with incorporating a unique tip in the scanning protocol and scanner software, for group iii, medit i600 direct intraoral classical scans will be obtained while applying only a basic simple splinting. the stl file obtained from the different scans will be sent directly to the dental laboratory and three cad/milled frameworks will be realized based on the acquired scans. the jigs' passivity will be tested in the patient's mouth by the single screw test followed by the screw resistance test and the screw resistance test parameter will be calculated. the results will be collected for statistical analysis.

Eligibility criteria:
inclusion criteria: * patients having a completely edentulous lower arch that could be restored by fixed screw-retained implant prosthesis. * patients having a substantial bone height and width at prospective implant sites to install four standard-size implants following the all-on-4 protocol. * patients having sufficient crown height space. exclusion criteria: * patients with bad oral hygiene. * patients with limited mouth opening. * vulnerable groups. * uncooperative patients. * patients receiving or undergoing radiotherapy or chemotherapy. patients with systemic diseases affecting bone metabolism. smokers.

Keywords: intraoral scanner photogrammetry full arch implant restorations passive fit one-screw test screw resistance test
paravertebral block (pvc) versus pectoral nerve block (pec)

Conditions: Breast Cancer

Summary: the purpose of this study is to compare two standard methods of pain control management used at spectrum health for patients undergoing breast surgery. the two methods being compared are the paravertebral block (pvb) and the pectoral nerve block (pec). postoperative pain control is essential following any major operative procedure. a variety of methods have been used to ensure adequate pain control, each with its own advantages and risks. increasingly, attention has focused on regional methods of analgesia, which may allow for reduction in systemic narcotic use and their associated complications. proposed benefits of regional analgesia and a resultant reduction in narcotic use include decreased risk of cancer progression, decreased length of stay, and decreased risk of ileus.

the purpose of this study is to compare the clinical profiles of two currently acceptable analgesia techniques. the most common regional block used to achieve postoperative analgesia following mastectomy is the paravertebral block, during which local anesthetic is injected into the paravertebral space which contains the thoracic spinal nerves, between the costotransverse ligament and the pleura. at our institution there has been recent interest in an alternative regional block. the pectoral nerve block is performed by injecting anesthetic between the pectoralis major and the pectoralis minor (pecs i) or between the pectoralis minor and the serratus anterior (pec ii). the proposed advantage of the pectoral nerve block for regional anesthesia during breast surgery is equal analgesic efficacy with fewer potential complications.

Eligibility criteria:
inclusion criteria: * female patients ≥ 18 years of age * total mastectomy or partial mastectomy with or without reconstruction or planned lumpectomy. * patient determined by their surgeon as medically able to receive a regional block for post-operative analgesia * patient agrees to participate in the study and signs informed consent exclusion criteria: * neoadjuvant radiation therapy * stage iv cancer * previous breast surgery (excluding percutaneous biopsies of all types) * history of either pvb or pec procedures * planned general anesthesia use during surgery * allergies to ropivacaine, midazolam, fentanyl, or propofol * pregnant women * prisoners * adults unable to consent * non-english-speaking patients

Keywords: surgery breast pectoral nerve block paravertebral block analgesia mastectomy
restoration vs. compensation in neurovisual rehabilitation of visual field defects

Conditions: Hemianopia; Brain Injuries, Traumatic

Summary: visual field defects (vfd) are a frequent effect of cerebral lesions especially after posterior cerebral artery stroke. the present study was conducted to compare effects of vision restoration training (vrt) and compensation training (visual exploration training, vet) on visual field performance.


Eligibility criteria:
inclusion criteria: * visual field defects after brain damage * lesion age above 6 months * documented brain lesions due to ischemic stroke, hemorrhage or tumor demonstrated by computer tomography or by magnet resonance imaging exclusion criteria: * hemispatial neglect * complete blindness * severe psychotic diseases * serious drug abuse * chronic degenerative diseases (dementia, multiple sclerosis) * severe motor impairments * noticeable low intelligence influencing proper comprehension of diagnostic and training instructions * considerable impaired vision (visual acuity below 0.1 generated by amblyopia, opacity of cornea or lens, maculopathy and other retinal diseases where vision impairment is expected in the next month (e.g. subretinal neovascularisation, retinitis pigmentosa, diabetic retinopathy) * inability to fixate due to central scotoma, pathological nystagmus or other forms of fixation disabilities
the effect of mindfulness programs on postoperative pain

Conditions: Post Operative Pain

Summary: participants undergoing hand surgery will be assessed and compared for postoperative pain. the patients' experience of going through surgery will be evaluated. the patient satisfaction and patient assessed outcomes will be measured.

participants undergoing hand surgery will be randomized into either a control group or one of two groups that undergo mindfulness training during the perioperative period. one of the treatment groups will be enrolled in the program "prepare for surgery, heal faster" provided by nyu. the other treatment group will be enrolled in wim hof method, a meditation program. this program is not provided by nyu, but instructions will be provided to the patient on how to complete the meditative exercises involved in this established method. postop pain medication and pain scores will be monitored.

Eligibility criteria:
inclusion criteria: * patient seen in dr. paksima's office * scheduled for hand surgery * aged 18+ * able to provide consent exclusion criteria: * less than 18 years old * inability to consent * not fluent in english
a six week efficacy, safety and tolerability study of v565 in crohn's disease

Conditions: Crohn's Disease

Summary: the purpose of this study is to evaluate the efficacy and safety of v565 in participants with active crohn's disease (cd).

this study will be a multiple-site, double-blind, placebo-controlled, parallel-group study in approximately 126 subjects with a confirmed diagnosis of cd for at least three months and have cd involving the ileum and/or colon. following a screening period of up to 28 days, subjects will be randomly allocated into one of two treatment arms: either v565 or placebo using a 2:1 active:placebo ratio for a treatment period of 6 weeks. subjects will be treated with study drug as an add-on to any permitted stable medications already being taken for cd.

Eligibility criteria:
inclusion criteria: * history of crohn's disease of at least 3 months duration prior to screening * crohn's disease activity index (cdai) score of ≥220 to ≤450 during screening * c-reactive protein (crp) ≥5 mg/l (or, if crp is normal, faecal calprotectin (fcp) ≥250 µg/g) at screening * permitted cd medication regimen expected to remain stable during the period of the study exclusion criteria: * previous lack of response or current contra-indication to an anti-tumour necrosis factor α (anti-tnfα) agent * certain complications of crohn's disease that would make it hard to assess response to study drug * known history or suspicion of inflammatory bowel disease other than crohn's disease * history of tuberculosis (tb) or latent tb infection that has not been treated * any significant illness or condition which would preclude effective participation in the study * gi infection as demonstrated by presence of enteric pathogens * pregnant or lactating women * abdominal surgery in the previous 6 months * unsuitable for inclusion in the study in the opinion of the investigator or sponsor for any reason that may compromise the subject's safety or confound data interpretation
diagnostic value of weight bearing ct for detecting meniscal tears

Conditions: Meniscus Tear, Tibial

Summary: this observational study will compare the clinical value of weight-bearing ct arthrography (wbcta) with that for mri in evaluating meniscal and cartilage lesions of the knee joint. the mri osteoarthritis knee score (moaks) and modified moaks for wbcta will be used to compare findings between mri and wbcta of the knee while comparing with surgical measurements using the icrs scoring system. the study hypothesis is that meniscal and cartilage lesions may be missed by non-weight-bearing mri, but detected by wbcta.

study objectives: aim 1 establish the accuracy of wbcta and mri for diagnosing knee cartilage and meniscal lesions in both surgical and non-surgical participants. hypothesis 1: pre-operative cartilage and meniscal scoring on wbcta is more accurate than mri, in comparison with arthroscopic assessment. aim 2 establish the accuracy of wbcta for detecting persistent and recurrent meniscal root and radial tears not detected by mri 6 months after meniscal repair (defined by diastasis of the repair or meniscal extrusion ≥3mm). hypothesis 2: six months following meniscal repair, wbcta detects persistent and recurrent meniscal root and radial re-tears not detected by mri. study type and design: this cross-sectional, observational study will compare wbcta with mri to evaluate rate of detection of meniscal and cartilage lesions. the inter-rater reliability of wbcta readings also will be assessed.

Eligibility criteria:
inclusion criteria: * male or female over 18 years of age with a knee mri acquired in the previous 10 days to evaluate for suspected meniscal or cartilage pathology. * body mass index (bmi) ≤ 45 kg/m2 * ability to stand with support without moving for at least 2 minutes. exclusion criteria: * end stage kidney disease * allergic to iodinated contrast material. * pregnancy * skin breakdown or rash at the knee joint which would prevent injection of the contrast. * any clinically significant degree of cognitive impairment or other condition, finding, or psychiatric illness at screening which, in the opinion of the investigator, affects their ability to ambulate to a sufficient degree and could compromise patient safety or interfere with the assessment of the safety of the study injection. * superficial or deep infection in or around the index knee joint or allergy to iodinated contrast media. * history of inflammatory arthritis, meniscectomy, or end-stage oa