Kornimate/medical-research-clean huggingface dataset:
clinical success of anterior and posterior crowns in a group of children treated under general anesthesia

Conditions: Prosthesis Failure, Dental

Summary: * this incidence study aims to evaluate the clinical success of anterior and posterior full-coverage restorations among a group of egyptian children treated under general anesthesia. * the main question it aims to answer: in a group of children, what is the clinical success of anterior and posterior full coverage restorations performed under general anesthesia?

this study consisted of clinical examinations of the participants treated under general anesthesia to evaluate the clinical success of anterior and posterior crowns that will be performed on the day of the dental treatment, then after 15 days, 3, 6, and 12 months recall examinations. - the level of parental satisfaction will be evaluated through a questionnaire that will be completed after 15 days, 3, 6, and 12 months.

Eligibility criteria:
inclusion criteria: * children aged between 2 and 5 years old. * children classified as american society of anesthesiologists class i; healthy (no acute or chronic disease, normal bmi percentile for age) * all children received pulp therapy techniques for vital teeth. exclusion criteria: * children with mental or neurological disorders. * children with developmental disorders and syndromes. * children whose parents have no mobile phone access.
autonomic responses during the valsalva maneuver and deep breathing test depend on the experimental setup

Conditions: Autonomic Nervous System Diseases

Summary: the purpose of this study is to determine the effects of procedural differences during the valsalva maneuver and deep breathing test in autonomic nervous system testing.


Eligibility criteria:
inclusion criteria: * male * ≥ 18 year * normal ecg-12 exclusion criteria: * any known disease * smoking * any intake of regular medicine
sleep, pain and function in people with chronic spinal pain and comorbid insomnia

Conditions: Chronic Low Back Pain; Chronic Neck Pain; Chronic Insomnia

Summary: this study is focused on people with chronic spinal pain. to investigate the impact of sleep problems on pain and function, 45 people with chronic spinal pain and comorbid insomnia will be compared to 45 people with chronic spinal pain without insomnia.


Eligibility criteria:
inclusion criteria cases: * nonspecific spinal pain (≥3 days per week and ≥3 months of chronic low back pain, failed back surgery syndrome \> 3 years prior, chronic whiplash, or chronic non traumatic neck pain) * aged between 18 and 65 years * seeking care because of neck pain or low back pain * native dutch speaker * having insomnia: in the absence of other intrinsic sleep disorders and shift work, insomnia is defined as \> 30 minutes of sleep latency and/or minutes awake after sleep onset for \> 3 days / week for \> 6 months * living or working within a radius of 50 km around the test location * not starting new treatments or medication and continuing their usual care 6 weeks prior to and during study participation (to obtain steady state) * referring from analgesics, caffeine, alcohol or nicotine in the previous 48 h of the assessments * nonspecific failed back surgery \> 3 years are permitted * not undertaking exercise (\>3 metabolic equivalents) 3 days before the experiment exclusion criteria cases: * severe underlying sleep pathology (identified through baseline data of polysomnography) * neuropathic pain * chronic widespread pain * being pregnant or pregnancy (including giving birth) in the preceding year * history of specific spinal surgery * thoracic pain in absence of neck or low back pain * shift workers * present clinical depression * bmi ≥ 30 inclusion criteria controls: * native dutch speaking * 18 to 65 years of age * having chronic nonspecific chronic spinal pain (≥3 days per week and ≥3 months of chronic low back pain, failed back surgery syndrome \> 3 years prior, chronic whiplash, or chronic non traumatic neck pain) * referring from analgesics, caffeine, alcohol or nicotine in the previous 48 h of the assessments * not undertaking exercise (\>3 metabolic equivalents) 3 days before the experiment * no new medication 6 weeks prior to the assessment * currently not undergoing any treatment (excl. medication) for chronic spinal pain exclusion criteria controls: * specific medical conditions (neuropathic pain, specific neck of back surgery, osteoporotic vertebral fractures, or rheumatologic diseases) * chronic widespread pain syndromes (fibromyalgia or chronic fatigue syndrome) * having insomnia (in the absence of other intrinsic sleep disorders and shift work, insomnia is defined as \> 30 minutes of sleep latency and/or minutes awake after sleep onset for \> 3 days / week for \> 6 months) * severe underlying sleep pathology * being pregnant or pregnancy in the preceding year * thoracic pain in the absence of neck or low back pain * diagnosed depression * bmi over 30
assess safety & reactogenicity of gsk biologicals' hib vaccine co-administered with or without chinese dtpw vaccine

Conditions: Haemophilus Influenzae Type b Disease

Summary: to assess safety and reactogenicity of gsk biologicals' haemophilus influenza type b vaccine co-administered with or without chinese dtpw vaccine administered alone in healthy infants (3, 4 and 5 months of age)

all subjects will be randomized into two groups. one group will receive dtpw vaccine co-administered with hib and another group will receive dtpw vaccine alone. a specific follow-up of solicited local and general symptoms after each vaccination. a specific follow-up of unsolicited symptoms after each vaccination. recording of serious adverse events reported during the study period.

Eligibility criteria:
inclusion criteria: * a male or female infant between, and including, 11 and 17 weeks of age at the time of the first vaccination. exclusion criteria: * planned administration of a vaccine not foreseen by the study protocol during the period starting 30 days before the administration of the first vaccine dose and ending 30 days after the last dose. * chronic administration of immunosuppressants or other immune-modifying drugs from birth until administration of first dose of study vaccine. * use of any investigational or non-registered product (drug or vaccine) within 30 days preceding the first dose of study vaccine, or planned use during the study period.
conditioned open label placebo for postoperative pain management

Conditions: Pain, Postoperative

Summary: the primary objective is to evaluate the efficacy of two conditioned open label placebos (colp): colp pill and colp odor to reduce opioid intake for postoperative (thoracic and spinal surgery) pain management compared to the opioid only usual treatment (tau).

patients, eligible for an elective thoracic or spinal surgery, will be randomized into either standard of care, colp_pill or colp_odor. patients in colp groups will be asked to pair each opioid intake with an open label placebo intake (either a pill or an inhalation) for postoperative (pod) day 0 to 17. from pod 2, patients in the intervention arms will be additionally asked to take olp alone 3 times a day. patients will have unrestricted access to pain killers. patients will daily assess opioid intake, pain intensity, side effects, mobility and sense of agency using a e-dairy.

Eligibility criteria:
inclusion criteria: * spinal or thoracic elective surgery for the indications mentioned above * able to give informed consent * interested in trying colp as complementary pain management therapy * able to fill a e-diary at home exclusion criteria: * cognitive impairment (moca score \<26) * inability to engage in the intervention of the study e.g. inability to communicate in french without a translator, severe hearing impairment without any hearing aid available at the time of intervention, anosmia or intolerance to eugenol. * acute psychiatric (e.g. psychotic or suicidal ideation) or somatic (e.g. unstable cardio-respiratory condition) co-morbidity preventing full engagement during intervention * opioid use disorder (toxicomania) or contraindication to pain management using opioids (allergy, refusal, ...) * intolerance to placebo ingredients
a prospective clinical study on a total hip resurfacing system

Conditions: Arthritis; Avascular Necrosis

Summary: this prospective clinical study is to demonstrate the efficacy and safety of recap total hip resurfacing system.


Eligibility criteria:
inclusion criteria: * intended for skeletally mature individuals undergoing primary surgery as a result of hip degenerative joint disease, or any composite diagnoses, including: * osteoarthritis * avascular necrosis * traumatic arthritis * legg perthes * rheumatoid arthritis
ultrasonographic evaluation of ovarian stromal vascularity in women with polycystic ovary syndrome (pcos)

Conditions: Ovarian Cysts

Summary: the most common endocrine condition in reproductive women is polycystic ovary syndrome. it has a prevalence of 5-10%. according to the rotterdam criteria, oligo/anovulation, clinic or biochemical hyperandrogenism, pcos morphology in ultrasonography, and the presence of these two criteria are required for diagnosis. the echogenicity of the ovarian stroma, vascularity, ovarian size, cystic pattern density, and subcortical organization of cysts are all significant considerations in ultrasonographic evaluation.

retrospective archive study. in the years 2018-2019, the ultrasonographic archives of pcos women will be analyzed retrospectively in the radiology department of usak education and research hospital. ultrasonographic (two-dimensional ultrasonography , conventional and other doppler) measurements of ovaries will be assessed in ultrasonographic data. patient's data ( menstrual cycle, androgenic findings, age, bmi etc..) will be obtained on the hospital records, pcos patient's phenotype will be evaluated according to national institutes health (nih) recommendations. the ovarian ultrasonographic findings of pcos women will be compared. this study approved by usak university medical faculty ethical committee april,06,2022. the ethical committee decision number is 57-57-04.

Eligibility criteria:
inclusion criteria: * reproductive period according to rotterdam criteria pcos women. exclusion criteria: women have not pcos criteria, non-reproductive period pregnancy postpartum ovarian mass underwent ovarian surgery.
effects of physical exercise on postmenopausal risk factors in women with osteopenia

Conditions: Osteopenia, Osteoporosis

Summary: menopause usually have a serious impact on a woman's life, associated with negative consequences for health and quality of life. early preventive assessments are very difficult to implement due to the complex hormone-deficiency-induced effects on a large variety of organs and systems with estrogen receptors. in fact, only a few types of interventions have the potential to comprehensively improve the various risk factors and complaints of the menopausal transition. in detail, however, not every form of exercise training or every training protocol is effective for exerting positive effects on selected risk factors. in particular, the training concept for addressing musculoskeletal or cardio-metabolic risk factors differ fundamentally. in several studies, we confirmed the effect of different complex training programs on risk factors of different postmenopausal female cohorts with special consideration of osteoporotic aspects. the training programs applied in this context were characterized by the consistent implementation of recognized training principles and an in general exercise intensity-oriented approach. recent studies confirmed the effectiveness of this proceeding for women with relevant postmenopausal risk factors including low bone strength. however, the crucial issue of the most effective, feasible and easily customizable training protocol for addressing postmenopausal risk factors remains to be answered, taking into account that the majority of exercise programs were realized in an ambulatory group setting. the aim of the study will be to evaluate the effects of an optimized physical training on risk factors and complaints of (early) postmenopausal women with special consideration of the osseous fracture risk. note (05.06.2020): of importance, the intervention has to be cancelled due to covid-19 lockdown in march 2020 after 13 months of intervention.


Eligibility criteria:
inclusion criteria: * (early)postmenopausal women, ( normal menopause, 1-5 years post) * osteopenia and osteoporosis at the lumbar spine or femoral neck bone mineral density (bmd) \<-1.0 standard deviation (sd) t-score, who) exclusion criteria: * bmd \<-4.0 sd t-score (bmd threshold for pharmaceutical therapy according to dachverband osteologie (dvo) guideline (mandatory for germany, austria, suisse) for woman 50-60 years). * prevalent clinical, low-trauma fractures * diseases and drugs with relevant effects on bone and muscle metabolism (e.g. glucocorticoids \>7.5 mg/d or bisphosphonate therapy); individual case assessment * diseases and drugs with relevant effects on cardiometabolic risk factors (e.g. severe hypertension with corresponding medical therapy); individual case assessment * severe cardiovascular events (e.g. stroke, coronary infarction) in the past. * other conditions, diseases that exclude exercise training in a group (≤10 persons).
pcsk9 polymorphism and risk of cardiac rupture

Conditions: Post-Infarction Heart Rupture; Gene Polymorphism

Summary: protein convertase subtilisin/kexin type 9 (pcsk9) plays a regulatory role in cholesterol homeostasis by promoting low-density lipoprotein receptor (ldlr) degradation. although the vast majority of the studies have focused on the role of pcsk9 in ldlr expression in the liver, an increasing body of evidence suggests that pcsk9 gene is also present in extra-hepatic tissues. a recent publication showed for the first time that pcsk9 is expressed in the ischemic heart and the expression is highest in the zone bordering the infarcted areas. furthermore, the expression of pcsk9 is maximal early, at 1 week of ischemia. mechanical complications (or cardiac ruptures) are uncommon but potentially lethal sequelae of acute myocardium infarction (ami) and are commonly associated with early mortality without appropriate surgical intervention. it's unknown why some patients develop these devasting complications following ami, while others not. interestingly, studies have shown that post-infarction cardiac rupture affect the border zone between the ischemic and normal area and occur within the first 3 to 5 days after ami. based on the aforementioned observations, it's likely to assume a relationship between pcsk9 expression and the development of post-ami cardiac rupture. therefore, the main purpose of the this project is to study the pcsk9 gene polymorphism and its association with cardiac rupture. investigators hypothesize that pcsk9 expression/secretion and development of post-ami cardiac rupture may be a part of the dynamic changes at cellular levels occurring in the ischemic heart of genetically predisposed patients.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute myocardial infarction with st sopra-elevation (control group) * clinical diagnosis of acute myocardial infarction complicated by cardiac rupture exclusion criteria: * absence of coronary artery disease

Keywords: pcsk9 cardiac rupture
incidence and risk factors for post-anesthetic morphine titration in recovery room after hip and knee arthroplasties

Conditions: Arthropathy of Hip; Arthropathy of Knee

Summary: despite the use of multimodal analgesia combining nerve block (nb) and systemic analgesia, intravenous (iv) morphine titration in the post-anesthetic care unit (pacu) after total hip (tha) and knee (tka) arthroplasty is required to relieve early moderate-to-severe pain. sedation occurrence during titration and a vas score higher than 60/100mm are two independent risk factors for postoperative pain during hospitalization. the association of nb and multimodal analgesia constitutes the reference in evidence-based recommendations. an adductor or femoral triangle block, alone or associated with periarticular infiltration, is recommended during tka. during tha, nb associated with surgical periarticular infiltration improves analgesia and rehabilitation this study aims to identify the incidence and risk factors of morphine titration in pacu after lower limb arthroplasty performed by 5 experienced surgeons and using a multimodal analgesic procedure


Eligibility criteria:
inclusion criteria: * total hip arthroplasty * total knee arthroplasty * uni-compartmental knee arthroplasty (uka) exclusion criteria: * bilateral surgery surgical revision hip fracture surgery other osteoarticular procedure(s) associated to hip/knee arthroplasty refusal to use data contra-indication of paracetamol, ketoprofen and dexamethasone
a rehabilitation education care program on return to work among head and neck cancer survivors

Conditions: Head and Neck Cancer

Summary: the purpose of this study will to identify factors (performance ability, physical function, psychosocial function, fear of cancer progression, social support, demographic characteristics, and disease-related characteristics) that impact the return to work and work status in survivors of hnc within one year after completion treatment. head and neck cancer survivors who have attended a rehabilitation education care program (recp) intervention will have better performance ability, physical function, psychosocial function, fear of cancer progress, social support, and lower return to work to patients who not attended with the intervention.

the purpose of this 2-year project will involve a randomized controlled clinical trial to evaluate the 3-months recp. eligible participants will be recruited from initial completion treatment to 6 months after completion treatment and randomized into a control group and an experimental group, with the control group patients receiving routine hospital care and the experimental group patients receiving the 3-months recp. outcomes will be assessed using return to work barrier scale (rtwbs), fear of progression questionnaire (fop-q-sf), social support scale (sss), university of washington quality of life scale (uw-qol), karnofsky's performance score (kps), katz activities of daily living scale (adl), and instrument activities of daily living scale (iadl). subjective data will be collected at four time points: baseline (6 months after completion of treatment)(t0) and then 9, 12, and 18months after completion of treatment (t1, t2, and t3, respectively). objective data will be assessed at the same time points. the mixed-model repeated measure anova will be used to analyze the data. the investigators plan to recruit 30 subjects for each group.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of head and neck cancer. 2. must be age were greater than 18 years and less than 64.5 years 3. must be able to better performance status and kps score more than 60 4. must be had completion of treatment more than 3 months exclusion criteria: 1. unemployment or retire at the time of cancer diagnosis 2. unstable systemic disease 3. poor performance status and kps score less than 60
biomolecular analysis for predicting response to regorafenib

Conditions: Glioblastoma; Glioblastoma, IDH-wildtype

Summary: the study envisages ngs analysis on tumor tissue from patients treated with regorafenib for recurrent glioblastoma as per standard care, with the aim to identify predictive biomarkers for response.


Eligibility criteria:
inclusion criteria: 1. recurrent glioblastoma after surgery and chemoradiation with temozolomide; 2. indication to treatment with regorafenib per standard of care; 3. written informed consent. exclusion criteria: none.

Keywords: regorafenib ngs predictive biomarker
monocyte priming when consuming a western diet

Conditions: Heart Diseases

Summary: to determine the mechanism of monocyte priming in humans, the study team will conduct a complete feeding trial in normal weight and metabolically healthy human subjects (20-45 years of age) using a western diet (wd), characterized as being high-saturated fat, high-fructose, and high-calorie for 8 weeks.

the goal is to challenge metabolically healthy human subjects with a high-calorie, western diet for 8 weeks to identify the metabolite(s) responsible for monocyte priming and use redox proteomics, rnaseq and chipseq to determine the genes and pathways involved in monocyte priming in humans. to reflect some key components of the typical western intake, the study team will compose the diet to be high in saturated fat (15% of total energy intake) and fructose (14% of total energy intake) with excess energy intake that is 25% higher than estimated total energy expenditure. a total of 30 participants, including 15 men and 15 women, will complete a run-in phase where weight stability will be achieved on the control diet. after weight is stabilized during the run-in period, participants will enter the experimental phase of the dietary intervention, where overfeeding will begin with additional calories provided by the key nutrients as noted above. participants will be monitored throughout the feeding trial. after completion of the 8-week overfeeding period, individuals will be allowed to return to a normal dietary intake. all study participants will be given access to counseling for weight reduction should it be needed following the overfeeding period.

Eligibility criteria:
inclusion criteria: * age 20-45 * planning to be available for the entire study period * able to speak and read english * normal weight (body mass index 18.5-24.9 kg/m2) * able to eat the prescribed diet * non-smoker exclusion criteria: * excessive alcohol consumption * history of chronic cardiometabolic disease or major risk factor, including diabetes, hypertension, hyperlipidemia, heart disease * history of prior surgical procedure for weight control or liposuction * use of weight loss medications in previous 6 months * recent self-reported weight change * severe pulmonary disease requiring supplemental oxygen * abnormal renal or liver function * history of non-skin cancer in the past 5 years * regular use of medications (prescribed or over-the-counter) that affect blood pressure, lipids, glucose, inflammation, or body weight * works night shifts * exercise per week \> 420 minutes total for moderate activity or \> 210 minutes for vigorous activity * any medical or behavioral indication that would make participation unsafe based on the judgement of the study physician * pregnant or lactating women * known or discovered intolerances, allergies or difficulty consuming any of the foods included in the study diets

Keywords: heart disease western diet high-calorie diet
combined package of interventions for environmental enteropathy

Conditions: Environmental Enteropathy

Summary: randomized, double-blind, placebo controlled trial of a combined intervention of zinc, albendazole, and multiple micronutrients in improving environmental enteropathy in malawian children.


Eligibility criteria:
inclusion criteria: * children residing in catchment area of limela, machinga district, malawi * aged 12-35 months * youngest eligible child in each household exclusion criteria: * severe acute malnutrition * severe chronic illness * children unable to drink 20 ml of dual sugar solution * children in need of acute medical treatment for illness or injury at time of enrollment