Kornimate/medical-research-clean huggingface dataset:
cyclin d1 as a prognostic factor in multiple myeloma and its association with the immunological prognostic factor pdl1 and clinical and biochemical lab tests

Conditions: Multiple Myeloma

Summary: multiple myeloma (mm) is the most common bone marrow malignancy of terminally differentiated plasma cells. it accounts for about 1% of all malignant diseases and 10% of haematological malignancies and takes the second place after non-hodgkin lymphoma . there are some serological and clinical criteria that help to detect the stage of mm and predict the patients' prognosis. these criteria include the level of m protein, calcium, haemoglobin, albumin, creatinine, β2-microglobulin and glomerular filtration rate (gfr).


Eligibility criteria:
inclusion criteria: 1. patients older than 18 year with newly diagnosed mm. 2. approval to sign an informed written consent. exclusion criteria: * 1. patient younger than 18 years. 2.refusal to sign an informed written consent.
prediction of risk of hypotension in hemodialysis

Conditions: Chronical Kidney Disease; Hypotension; Residual Blood Volume; Hemodialysis

Summary: the main objective is to establish a statistical predictive model of the risk of intradialytic hypotension during hemodialysis (hd) or hemodiafiltration (hdf) sessions based on the measurement of residual blood volume and excess extracellular hydration. the secondary objective is to study the impact of dysfunction in the mechanisms of compensation for decreased blood volume (heart disease, neuropathy, drugs) on the risk of intradialytic hypotension.

the duration of the study is 4 weeks for each patient. it will first be carried out a spectral analysis of heart rate variability (chu of clermont ferrand only) and a measurement of intracellular and extracellular volumes by bioimpedancemetry. during the next 9 sessions, the decrease in the vsr will be recorded using an optical haematocrit measurement system. blood pressure and heart rate will be measured every 30 minutes using an automatic blood pressure monitor and whenever the patient's nurse deems it necessary.

Eligibility criteria:
inclusion criteria: * 18 years old minimum patients * patients with chronic end-stage renal failure * patients treated with hemodialysis for at least 3 months, 3 times a week (duration of sessions 3 to 5 hours) * patients with at least 2 episodes of intradialytic hypotension in the last month * patients without acute events within 3 months prior to inclusion * patients affiliated with or receiving social security benefits exclusion criteria: * hemoglobin levels outside the limits of measurement (\ 15g/l) * patients whose probable survival does not exceed 6 months * patients with progressive acute pathology * patient following another research protocol that may influence results * patients with psychiatric pathology or cognitive impairments that make them unable to give informed consent
study on potential biomarkers associated with clinical phenotype of egfr-tkis in no-small cell lung cancer in china

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: to understand 295 gene mutation mutation status (include egfr, her2, kras, braf, pik3ca,ect) by deep sequencing in chinese patients with pulmonary adenocarcinoma and their relationships with the patients' clinical features (including sex, age, smoking history and adenocarcinoma subtype), specify the predictive significance of the genes mutations for new targeted therapies in nsclc patients, and better understand the molecular mechanism drug resistance to egfr-tkis.

this study is prospective to identify biomarkers to resistant to afatinib，gefitinib and erlotinib in non-small cell lung cancer patients. mutations of whole exon of 295 gene are analysed by deep sequencing in chinese patients with non-small cell lung cancer and their relationships with the patients' clinical features (including sex, age, smoking history and adenocarcinoma subtype), specify the predictive significance of the genes mutations for new targeted therapies in nsclc patients, and better understand the molecular mechanism drug resistance to egfr-tkis.

Eligibility criteria:
inclusion criteria: * age\>18 years,both male and female * histologically confirmed patients with pulmonary adenocarcinoma (stage i-iv) * ecog 0-2 * patients with enough paraffin tissue specimens or fresh tissue for detection * quality of the dna extracted from the tissue samples ensures that the dna can be used in dna sequencing * subjects who provide detailed clinical and follow-up information exclusion criteria: * patients with other tumors * patients suffering from other serious diseases like infectious diseases (viral hepatitis, hiv,etc) * pregnant women shall be excluded
validation of a surgical navigation algorithm during knee replacements in patients with knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: ganymed robotics develops a novel solution of surgical navigation to assist surgeons during knee remplacement surgeries. the aim of this study is to train and validate this novel algorithm.

during knee replacement surgery, per-operative images of the patient's knee will be taken. these images will then be compared with the pre-operative ct-scan of the patient using the novel navigation algorithm. the algorithm will be validated based on its ability to correctly compare both modalities (pre-operative and per-operative images).

Eligibility criteria:
inclusion criteria: * adults patients who signed the icf of the study * patients suffering from knee osteoarthritis requiring a total knee replacement surgery exclusion criteria: * patient under the age 18 * patient unable to consent to the study or refusing to participate * patient with history of knee replacement on the knee that will be operated again * patient unable to realize a pre-operative ct-scan * patient not covered by french health insurance or equivalent.
negative pressure wound therapy compared to traditional care after skin grafting

Conditions: Wound of Skin; Wound Heal; Wound; Wound Open; Wound Breakdown; Skin Wound; Skin Scarring

Summary: the aim of this study is to compare negative pressure wound therapy to traditional care after split-thickness skin grafting in patients aged over 18.

split-thickness skin grafting (stsg) is one of the most commonly used techniques in reconstructive plastic surgery and dermatology. skin grafts are being used to cover skin defects caused by multiple etiologies. traditionally, patients are immobilized in bed or in wheelchair for up to five days after surgery. long immobilization decreases patients overall ability to function and increases the length of the stay in hospital. negative pressure wound therapy (npwt) have been used successfully in treatment of acute, chronic and diabetic ulcers. it is proposed that npwt increases capillary blood flow, decreases bacterial contamination, seroma formation and swelling. using npwt on split-thickness skin grafts after burns is well documented. it increases skin graft take ratio and speeds up healing. aim of this study is to compare npwt to traditional treatment after stsg for any indication in patients aged 18 to 99. this is a two-arm, multicenter, randomized prospective trial with 160 patients.

Eligibility criteria:
inclusion criteria: * wound requiring skin graft surgery * voluntary exclusion criteria: * not voluntary * size of wound exceeding 15x15cm or 5x20cm * previous skin graft operation to the same wound * inability to co-operate * wound depth over 1.5cm * multiple wounds requiring skin grafting * active infection in wound * active osteomyelitis in region of wound * flap reconstruction of the wound * region of wound not suitable for negative pressure wound therapy (for example toes, foot sole)

Keywords: negative pressure wound therapy skin graft split-thickness skin graft
clinical and microbiologic characteristics of cephalosporin-resistant e. coli-pitt protocol

Conditions: E Coli Infections

Summary: the purpose of this study is to review patients with e. coli infections at upmc from september 1, 2008 to august 31, 2010 to determine if these infections have arisen in the community rather than in hospitals or nursing homes and determine their clinical outcomes. the specific aims of this study are to: 1. review whether cephalosporin-resistant e. coli infections are hospital-acquired, healthcare-associated or community-associated. 2. determine the clinical outcome of the patients according to the antibiotics given.

de-identified data will be obtained by the honest broker for the requested time period. in addtion, the honest broker will work with the microbiology laboratory to collect the isolates associated with the de-identified data. all data and samples will be de-identified. de-identified data will be given to the nurse coordinator to complete the case report forms and enter the data into the password protected database and the de-identified isolates will be stored and analyzed on the 8th floor scaife in dr. yohie doi's laboratory.

Eligibility criteria:
inclusion criteria: * patients with e. coli infections at upmc exclusion criteria: * not meeting entry criteria

Keywords: e. coli isolates
efficacy of warming garment in the perioperative period with integrated chemical heat packs to maintain normothermia

Conditions: Hypothermia

Summary: efficacy of stand-alone, non-tethered, self-applying warming garment in the preoperative, intraoperative and postoperative recovery period; using an integrated chemical heat pack construction, with a view to maintaining normothermia during the peri-operative period

subjects will be randomized into two groups. the first group will have the standard warming devices currently used which consists of a forced air warming device. this will be applied in the form of a gown in the pre-operative area. the device is called the bair paws. (subjects will either continue with this or have a separate forced air warming device applied in the operating room called a bair hugger.) this device is non experimental and is fda approved and used within the hospital to keep patients warm. they will then have their temperature taken and documented by the staff at various prescribed times. the second group will receive the warming devices being studied which consist of a jacket, pants, gloves and socks with integrated air-activated chemical heat packs. the garment is applied at least twenty minutes prior to surgery. the same warming device will be maintained in place throughout the surgery and the period of post-anesthesia. intraoperative period: the participants temperature will be monitored and documented at prescribed times. postoperative period: the participants will have temperature monitored in the post anesthesia care area. your part in this study will last until you are admitted to your room after surgery or you change into your own clothes prior to discharge.

Eligibility criteria:
inclusion criteria: male female asa physical status classification system class i asa physical status classification system class ii age 18-80 exclusion criteria: asa physical status classification system class iii -vi body mass index greater than 37.0

Keywords: normothermia hypothermia
effects of cft in individuals with cnlbp

Conditions: Chronic Pain; Neuropathic Low Back Pain

Summary: this research aims to deepen the understanding of the interplay between chronic neuropathic low back pain and its effects on physical health, mental well-being, and overall quality of life. additionally, it will evaluate the impact of cognitive functional therapy (cft) and core strengthening programs on managing chronic neuropathic low back pain. the study is grounded in the hypothesis that cft will offer a comprehensive, multidisciplinary, and holistic therapeutic approach for individuals suffering from chronic neuropathic low back pain.

in july 2020, the international association for the study of pain (iasp) revised the definition of pain, according to which pain is an unpleasant aesthetic and emotional experience related to, or appears to be related to, real or potential tissue damage. chronic pain is characterized by a long duration, exceeding 6 months. chronic neuropathic pain is caused by damage or disease of the somatosensory nervous system. cognitive functional therapy (cft) is a multidimensional, patient-centred intervention that directly explores and manages cognitive, psychological and social factors deemed to be barriers to recovery in chronic low back pain (vibe fersum k et al., 2013; meziat filho, 2015; meziat filho et al., 2016; o'keeffe et al., 2015a; rabey et al., 2015; meziat-filho et al., 2018). the cft approach centres on the retraining of maladaptive movement patterns, reconceptualising patient pain beliefs, and addressing any relevant cognitive, psychological, social or lifestyle factors (o'sullivan p., 2005). cft is an integrated behavioral approach for individualizing the management of people with disabling lbp once serious (eg, malignancy, infection, inflammatory disorder, and fracture) and specific pathology (eg, nerve root compression with progressive neurological deficit with or without cauda equina symptoms) has been excluded (o'sullivan et al., 2018).

Eligibility criteria:
eligible participants were * adults (aged ≥18 years) with chronic (≥ 3 months) low back pain prior to surgery, * who consent and compliance with all aspects of the study protocol, methods, providing data during follow-up contact. exclusion criteria were * serious spinal pathology (eg, fracture, infection, or cancer), * any medical condition that prevented being physically active, * being pregnant or having given birth within the previous year, * inadequate greek literacy for the study's questionnaires and instructions, * surgery scheduled within 4 months, * bmi greater than 40 kg/m2, * history of psychogenic illness or manic episode, * history of other neuromuscular disorder.

Keywords: chronic pain neuropathic pain low back pain
upar pet/ct and fdg pet/mri for preoperative staging of bladder cancer

Conditions: Urinary Bladder Neoplasms

Summary: the sensitivity and specificity of upar pet/ct with the radioligand 68ganota-ae105 and fdg pet/mri for preoperative detection of regional lymph node metastases in urinary bladder cancer

the sensitivity and specificity of 68ga-nota-ae105 pet/ct and fdg pet/mri for detection of regional lymph node metastases will be tested by observer-blinded readings and compared to diagnostic performance of conventional preoperative procedure. the reference test will be histopathology of lymph nodes obtained by operative lymph node dissection based on 6 regions. the suspected lymph nodes will be assigned to 6 regions based on the images. during the following operation the lymph nodes will be removed and analysed in each of these regions.

Eligibility criteria:
inclusion criteria: * biopsy-verified urinary bladder cancer * the participants must be capable of understanding and giving full informed written consent age above 18 years exclusion criteria: * pregnancy * lactation/breast feeding * age above 85 years old * weight above 140 kg * treatment with neoadjuvant chemotherapy * known allergy towards 68ga-nota-ae105 * other malignant disease within last 5 years, except for non-melanoma
effect of parental attitude on functional and physical level of children with cystic fibrosis

Conditions: Cystic Fibrosis; Cystic Fibrosis in Children

Summary: some parents may be more protective of children with cf due to concerns about worsening of the disease due to infection, which can affect their functional level. the goal of this observational study is to learn about the family's protective approach to the functioning and disease course of children with cystic fibrosis (cf) to determine whether there are possible negative effects. there will be an alternative viewpoint offered to clinicians regarding the management of cf with outputs of this study.

cystic fibrosis (cf) is an inherited disease characterized by pulmonary involvement. children with cf may have low levels of physical activity, physical fitness and functional capacity, and peripheral muscle weakness. parents who take care of children with cf may be protective of their children's social environment due to reasons such as the risk of infection. based on the idea that parents may have potential limitations on their children with cf, the aim of this study was to examine the effect of parental illness beliefs and anxiety levels on the functional and physical level of the child. children with cf will be administered modified shuttle walking test, munich physical fitness test, quadriceps muscle strength and hand grip strength test, respiratory function and respiratory muscle strength test, child physical activity questionnaire, shortness of breath beliefs questionnaire, revised cystic fibrosis questionnaire, parental attitude scale, perceived social support scale. parents will be administered the shortness of breath beliefs questionnaire (parent version), revised cystic fibrosis questionnaire (parent version), parent attitude scale, fear of disease progression questionnaire for parents. the level of correlation between the outcomes of the scales administered to parents and the assessment outcomes administered to children will be examined.

Eligibility criteria:
* inclusion criteria: 1. for a child 1. to be between 7-17 years old, 2. living with family or caregiver. 2. for the parent 1. being the mother, father or other caregiver of the child, 2. voluntarily agreeing to participate in the study on behalf of both the child and oneself. * exclusion criteria: 1. for the child 1. having cognitive impairment that would prevent participation in the study or being able to cooperate with the measurements and not being able to adapt, 2. history of previous lung or liver transplantation, 3. history of hospitalization within the last 1 month, 4. having a neurological or orthopedic comorbidity that affects mobility. 2. for the parent 1. having cognitive impairment at a level that prevents participation in the study 2. not living in the same household with the child.
focus group study on the feeling tone mindfulness course

Conditions: Mindfulness; Self-Compassion; Depression; Anxiety; Stress; Well-being

Summary: this is an academic research study aiming to explore the acceptability, feasibility, and effectiveness of a four-week feeling tone mindfulness course by gathering qualitative feedback from course participants in a focus group format.

this is a follow-up study of the four-week feeling tone mindfulness course study, exploring the acceptability, feasibility, and effectiveness of the four-week feeling tone mindfulness course by gathering qualitative feedback from course participants in an online (e.g., zoom), focus group format. a trained moderator will use a semi-structured interview guide with a set of questions to facilitate focus group discussions. each focus group session will last for about two hours. with the consent from focus group participants, each focus group will be audio-recorded. after participants have completed the focus group, they are eligible to receive hkd100, as a token of thanks to their support and participation to this focus group study.

Eligibility criteria:
inclusion criteria: * aged 18 or above * speak and understand cantonese as well as written chinese to a level where the participant can fully take part in the focus group session without the need for translation support * have means to access online teleconferencing meeting software (e.g., zoom), online surveys (to give their informed consent and to schedule a focus group session), online materials, and short message service (sms) or whatsapp messenger. * participants who have completed the four-week feeling tone mindfulness course exclusion criteria: * n/a
music therapy: an adjunct to gastroschisis infants' care

Conditions: Gastroschisis

Summary: the investigators hope to determine if music therapy will have beneficial effects on physiologic parameters, behavioral states, and pain scale evaluations in infants with gastroschisis defects and if music therapy promotes parental/caregiver relaxation and demonstrates to the parent/caregiver that music is an effective tool to calm and soothe their infant at risk for chronic gastrointestinal discomfort. babies will be enrolled during the perinatal period, with therapy to begin after surgical repair of the gastroschisis defect and when the neonatologist deems the baby stable enough for music therapy intervention. enrolled subjects may receive up to 3 music therapy sessions/week and these sessions may continue until discharge. there is no follow up after discharge. each one hour session (20-30 minutes of music and 30 minutes of quiet) will include: 1. pre music therapy behavior state will be assessed using cries scale and recorded. 2. five minutes of baseline vital signs will be recorded. 3. music therapy lasting 20-30 minutes, will start. music therapist will use guitar and lap harp to perform live lullaby tupe music with or with out vocals. decibel levels will be maintained at 65-75db. session will stop if infant shows any signs of distress/agitation. vital signs will be collected every 1-4 minutes during music session. 4. after session behavior state using cries scale will be recorded. 5. family/caregiver will be given a questionnaire to fill out. 6. 30 min of quiet will start. 7. at the end of quiet time, behavior state and vital signs will be recorded for the last time.

prior to starting the music therapy session, family/caregivers, if present, will be informed of study session progression. they will be reminded of appropriate behavioral protocol to maintain therapeutic environment during session - i.e. minimal taking \& touching, cell phones off etc. a "do not disturb - music therapy session in progress" will be posted outside pts room on the door. behavioral state data and vitals signs collected during sessions will be entered into a database. also recorded, will be general information about the baby and its mother, such as, gestational age, apgar scores, mothers age and race, number of days post surgical repair etc.

Eligibility criteria:
inclusion criteria: 1. diagnosis of gastroschisis 2. patient is stable enough to receive music therapy as determined by neonatologist 3. patient has passed their newborn hearing screen exclusion criteria: 1. neonatologist feels patient/family would not be an acceptable research candidate.

Keywords: gastroschisis nicu inpatients post surgical repair music therapy
a study of pc sequential pemetrexed single drug maintenance treatment for nsclc and related predictive biomarkers

Conditions: Non-small Cell Lung Cancer

Summary: pfs


Eligibility criteria:
inclusion criteria: .≥65 years or ps 2 * patients who were diagnosed by the histologic, cytologic diagnosis of iv non-small cell lung cancer * patients received no chemical therapy or only received targeted therapy,and there is evidence show the patent is pd * presence of at least one index lesion measurable by ct scan or mri * leucocyte ≥ 3.5×109/l * neutrophil ≥ 1.5×109/l * platelet ≥ 80×109/l * hemoglobin ≥ 9g/l * alt and ast ≤ 2.5×uln ,tbil≤ 1.5×uln * bun≤ 1.5×uln * signed written informed consent exclusion criteria: * squamous carcinoma or small cell lung cancer * patients were allergic to pemetrexed * patients received chemotherapy before * uncontrolled acute infection .uncontrolled pleural effusion * severe symptomatic heart disease * severe infection or metabolic disfunction * patients with other malignant tumor * uncontrolled brain metastases * patients have accepted other clinical trials * female patients during their pregnant and lactation period, or patients without contraception * mental disorientation of disorder * glucocorticoids taboo

Keywords: progression free survival