Kornimate/medical-research-clean huggingface dataset:
study of binaural squelch effect in unilateral otosclerosis

Conditions: Otosclerosis of Middle Ear; Unilateral Hearing Loss

Summary: patients with unilateral transmission hypoacusis due to otosclerosis undergoing stapedectomy surgery will be prospectively included. they will be undergoing a free field vocal audiometry using the oldenburg matrix software to evaluated the squelch effect gain between audiometry before and after 9months after surgery. our hypothesis is to show a squelch effect with the rehabilitation of the binaural audition.

otosclerosis is one of the main causes of transmission hypoacusis. it can be treated with stapedectomy surgery. but the understanding ability in noise has not been really studied. the oldenburg matrix test is a well know test in audiology and allow to study the understanding in noise. this study included all the patients coming in our center for stapedectomy for otosclerosis with controlateral audition under 30 decibels (db) loss. they will all undergo the matrix test in three situations: vocal material and noise from the front of the patient (s0n0 situation); vocal material from the front and noise from the bad-earing side (s0n-90 situation); vocal material from the front and noise from the good-earing side (s0n90 situation). this might give three informations: -squelch effect which is the difference between speech reception threshold (srt) in s0n90 situation at 9month after surgery and before surgery. the squelch effect is the ability of cortical discrimination to extract spatial cues and information providing from two different sources. so we considered the situation before surgery as a unilateral condition and the surgery rehabilitation as a bilateral condition. * head shadow effect which is the difference between s0n90 and s0n-90 audiometry situations. the head shadow effect is the difference in the speech reception threshold (srt) due to diffraction effect of the physical sound wave. * binaural benefit which is the difference between s0n0 situation after and before surgery. the binaural benefit is the srt gain of both ear with same threshold comparing to a gap of threshold between the two ears. the patients will also filled two questionnaires of quality of life: abbreviated profile of hearing aid benefit (aphab) and speech and spatial questionnaire (ssq). the aim is to show the benefit of the surgery in otosclerosis for comprehension in noise.

Eligibility criteria:
inclusion criteria: * diagnosis of otosclerosis * controlateral audiometry under 30db loss * the ear to be operated with a transmission over 30db exclusion criteria: * otosclerosis which has already operated on the ear studied * other cause of transmission hypoacusis * transmission after surgery other 30db
effects of pilates exercises on hearing impairment children

Conditions: Hearing Impaired Children

Summary: this study will determine the effects of pilates exercises on static and dynamic balance in children with hearing impairment. children with hearing impairment often encounter challenges in their motor development, including difficulties in maintaining balance and mobility. impaired balance and limited mobility can significantly impact their overall physical well-being and functional independence. therefore, it becomes crucial to explore effective interventions that can address these specific needs and promote improve balance and mobility in this population. pilates, a mind-body exercise approach, has gained recognition for its potential benefits in enhancing balance, flexibility, and core strength in various populations.

a randomized clinical trial will be conducted through convenient sampling. subjects will randomly be allocated into two groups experimental group will receive balance exercises in addition to pilate exercise while control group will receive will receive conventional therapy for strength, balance and postural stability. the duration of the treatment will be 10 weeks for 3 days a week for 45 minutes. pediatric balance scale, pediatric reach test (pediatric functional reach test) and timed up and go test will be used as outcome measure. data will be analyzed on spss version 29.0; normality of the data will be checked and tests will be applied according to the normality of the data either it will be parametric test or non-parametric based on the normality.

Eligibility criteria:
inclusion criteria. * age between 5 to10 years * having greater than 24 score of mini mental state examination (mmse-c) for children * children diagnosed with congenital sensorineural hearing impairment * having a hearing loss\>75db * able to follow instructions exclusion criteria: * presence of any visual, physical or mental disability in addition to hearing loss, or any orthopedic or neurological problem that may affect balance * severe hearing losses were greater than75db * parents or patient refuse to take part * have participated in other therapy programs during our intervention

Keywords: balance hearing impairment pilate exercises
effect of mobile phone addiction with forward head posture on pain and cervical functions

Conditions: Forward Head Posture

Summary: to investigate the effect of mobile phone addiction with forward head posture on the endurance of deep neck flexor muscles, respiratory functions, pain pressure threshold , and neck functional disability level.

nowadays, the mobile phone has become an important requirement. the number of mobile phone users and the duration of mobile phone use are increasing rapidly, and the side effects can be detrimental one of them is forward head posture. prolonged use of the mobile phone has also affected posture, resulting in many musculoskeletal disorders or improper posture. neck posture, particularly in a sitting position, is regarded an essential contributing factor to the development and long-term maintenance of cervical pain and headache. neck flexed posture increased due to the frequent use of the relatively small screen of a mobile phone compared to that of a desktop computer. constant use may also have unexpected consequences: increased stress on the cervical spine. forward head posture (fhp) is the most common side effect of prolonged, sustained mobile and tablet use. this leads to extension at atlantooccipital (c1 to c2) joints with flexion of lower cervical spine (c4 to c7) and flattening of mid cervical lordosis which cause joint dysfunction associated with negative affection of lung function, abnormal afferent information affecting the tonic neck reflex and encourages the gradual adaptation of fhp.

Eligibility criteria:
inclusion criteria: 1. forward head with craniovertebral angle less than 50 degree. 2. both sexes will participate in this study. 3. their age will be ranging from 18-40years (molaeifar et al., 2021). 4. body mass index is ranged from 18-25 kg /m2 (molaeifar et al., 2021). 5. area of mobile phone is 17 × 8cm. 6. participants will be randomly allocated into 2 groups, group (a) should not have addicted to mobile phone and group (b) should have addicted to mobile phone. exclusion criteria: 1. previous cervical operation. 2. musculoskeletal disorders such as cervical spine fracture, myelopathy, spinal cord tumor. 3. neurological conditions that affected head, neck, and upper limbs. 4. cervical disc or spondylosis. 5. respiratory diseases such as restrictions in lung function.

Keywords: cervical function, forward head posture, mobile phone addiction, pain
human umbilical cord mesenchymal stem cells for alport syndrome

Conditions: Alport Syndrome

Summary: the goal of this clinical trial is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cells (huc-msc) in the treatment of alport syndrome (as) in a randomized, single-blind, placebo-controlled trial, to provide a clinical basis for the development of stem cell products for the treatment of as, and to further clarify the therapeutic effect of huc-msc in the treatment of as.


Eligibility criteria:
inclusion criteria: * 3 years old ≤age ≤ 12 years old; * meet the diagnostic criteria of alport syndrome; * positive proteinuria or combined hematuria; * chronic kidney disease (ckd) stage: i-iii stage children, that is, glomerular filtration rate greater than 60 ml/min.1.73m2; * no history of infectious diseases within 1 week before treatment; * negative infectious disease screening; * no allergic state and related clinical manifestations; * signed informed consent (children or their families). exclusion criteria: * age \ 12 years old; * alport syndrome patients with only microscopic hematuria and normal glomerular filtration rate; * patients with significantly reduced renal function, chronic kidney disease stage iv or v, alport syndrome; * patients with other renal diseases; * have a history of severe allergic reactions or be allergic to 2 or more foods or drugs; * known allergy to stem cells or stem cell-derived products or ingredients in stem cell preparations; * have severe heart, liver, lung and other organ dysfunction or have tumors; * those with developmental malformations of the urinary system; * those with autoimmune diseases and regular use of immunosuppressants; * those with serious infectious diseases that are not under control; * those with a history of infectious diseases such as hbv, hcv, hiv, syphilis; * history of surgery or acute trauma or blood loss exceeding 200ml within 3 months; * participated in other clinical studies within 3 months; * have received any cell product or derivative product treatment within 12 months; * other circumstances that the researcher deems inappropriate for inclusion.

Keywords: alport syndrome human umbilical cord mesenchymal stem cells randomized clinical trial
study of geriatric patients aged 75 years or older treated and cured for localized prostate cancer: case-control study

Conditions: Prostate Cancer Cured; Healthy Population Control

Summary: this is a multicenter pilot study, proposed for cases and controls 3 departments in france. cases are cured patients who have had prostate cancer for at least 10 years. cookies are healthy subjects selected by lottery on voter list. volunteer subjects (cases and controls) are offered a consultation and assessment with an geriatrician.

volunteer subjects (cases and controls) are offered a consultation and assessment with an geriatrician. during this consultation, adl, iadl and mms questionnary will be completed. neurocognitif testing will be done.

Eligibility criteria:
inclusion criteria for patients: * patients aged 75 years or more * patients with a personal history of prostate cancer with a diagnosis ≥ 10 years * patients who received curative treatment (surgery, radiotherapy,hormone therapy, brachytherapy, technical ablative) for localized prostate cancer * patients considered cured of prostate cancer (regardless of initial treatment) * patients with previously agreed to participate in a case-control study in the general population (study qalipro) as a case and volunteer to receive an assessment of geriatric * signature of consent * affiliation to a social security system exclusion criteria for patients: * patients under 75 years * patients with recurrent or metastatic * persons deprived of liberty or under guardianship inclusion criteria for control population: * male subjects * subjects of 75 years or more * subjects that do not have cancer or a history of cancer (except basal cell skin cancer) * subject has previously agreed to participate in a case-control study in the general population (study qalipro) as a voluntary witness and to benefit from a balance oncogeriatrics * subjects who gave their written consent to participate in the study

Keywords: prostate cancer cured aged patients
a prospective single-center cohort study "preoperative identification of sentinel lymph nodes using contrast-enhanced ct lymphography in breast cancer patients"

Conditions: Breast Neoplasms; Sentinel Lymph Node

Summary: the main hypothesis of this study is that contrast-enhanced ct lymphography can be used for preoperative visualization of sentinel lymph nodes in breast cancer patients. we assume that ct lymphography is a high-sensitivity and high-specificity method for sentinel lymph nodes' mapping in breast cancer patients. we also assume that positive predictive value and negative predictive value for identification of presence or absence of metastases in sentinel lymph nodes (sln) will be high enough for preoperative diagnosis of sln metastases in breast cancer patients. this study will use ct lymphography with periareolar injection of iopamidol and standard protocols of sentinel lymph nodes biopsy using intraoperative indocyanine green (icg) fluorescence.


Eligibility criteria:
inclusion criteria: * age \> 18 years; * signed informed consent; * histologically confirmed breast cancer exclusion criteria: * iodine allergy; * presence of distant metastases of breast cancer; * body mass index more than 40; * chronic cardiovascular and cerebrovascular diseases in the stage of decompensation or recent acute conditions (myocardial infarction, brain stroke, etc.) * suspected pregnancy; * severe hypothyroidism; * bronchial asthma in the stage of decompensation; * decompensated diabetes; * kidney or hepatic failure.

Keywords: breast cancer sentinel lymph nodes ct-lymphography
preparing family planning clinics to streamline integration of hiv prevention services for young women in kenya

Conditions: HIV Infections; Contraception; STI

Summary: this a prospective, open-label implementation project to catalyze integration of hiv prevention and prep care services for adolescent girls and young women in family planning clinics in kenya.

investigators will conduct a stepped-wedge cluster-randomized programmatic project to integrate prep provision within a combination hiv prevention package in 12 family planning clinics in kisumu, kenya- a region with an hiv prevalence of up to 28% among young women. the project will optimize and sustain prep delivery with existing family planning staff, supported through training and ongoing technical assistance. the investigators will rigorously evaluate program reach, effectiveness, adoption, implementation, maintenance, and impact using validated implementation science frameworks and how clinics build new efficient delivery systems.

Eligibility criteria:
inclusion criteria: * female of reproductive age * sexually active * able and willing to provide informed consent * hiv negative, according to national hiv testing algorithm * has at least one risk factor for hiv as defined by the kenya national aids and sti control program exclusion criteria: - otherwise not eligible based on the above inclusion criteria
bioequivalence study between two oral formulations of famotidine tablets under fed conditions

Conditions: Bioavailability

Summary: compare the rate and extent of absorption of famotidine 40 mg tablets, administered as 1 x 40 mg tablet under fed conditions.


Eligibility criteria:
inclusion criteria: * healthy men or women 18 years of age or older * body mass index below 30.0 kg/m2 * willing to participate and sin a copy of the informed consent form exclusion criteria: * recent history of drug or alcohol addiction or abuse * pregnant or lactating women * history of allergic response to heparin, famotidine, other h2-receptor antagonists, or other related drugs * evidence of a clinically significant disorder or whose laboratory results were deemed to be clinically significant * smoking more than 25 cigarettes per day

Keywords: bioavailability famotidine
immediate effect of non-elastic taping on gait balance in stroke patients

Conditions: Stroke

Summary: after a stroke, most patients have poor ankle control and difficulty walking. considering that proper foot placement will provide a more balanced and controlled gait, the aim of this study was to investigate the immediate effect of non-elastic ankle taping providing eversion support on gait balance in stroke patients.

the study included 30 stroke patients. participants were randomly assigned to two groups: intervention group(n=15) and the control group(n=15). the control group received 45 min of conventional physiotherapy. the intervention group received 45 min of conventional physiotherapy after nonelastic taping, which provides eversion support. the gait balance of both groups was evaluated using the dynamic gait index before and after treatment. . pre- and post-intervention data were statistically analyzed and compared.

Eligibility criteria:
inclusion criteria: * having a stroke diagnosis at least 6 months ago, * being between the ages of 18 and 75, * having a spasticity grade of 0, 1, 1+, 2 according to the modified ashworth scale, * having no cooperation problems and being mobilized without support. exclusion criteria: * orthopedic problems such as surgical intervention, fracture history, presence of cognitive, visual, or cardiovascular diseases * skin sensitivity in the foot and ankle that may affect gait.

Keywords: balance gait immediate stroke taping
effect of bio-mechanical awareness and core stability exercises on mechanical low back pain

Conditions: Mechanical Low Back Pain

Summary: investigate the effect of bio-mechanical awareness and core stability exercises on mechanical low back pain among egyptian physiotherapists

the aims of this study are: 1. to investigate the effect of bio-mechanical awareness and core stability exercises on the intensity of low back pain among egyptian physiotherapists. 2. to investigate the effect of bio-mechanical awareness and core stability exercises on and back muscle endurance among egyptian physiotherapists. 3. to investigate the effect of bio-mechanical awareness and core stability exercises on level of function (disability) associated with low back pain among egyptian physiotherapists. 4. to investigate the effect of bio-mechanical awareness and core stability exercises on fatigue among egyptian physiotherapists. 5. to investigate the effect of bio-mechanical awareness and core stability exercises on psycho-social factors at work among egyptian physiotherapists.

Eligibility criteria:
inclusion criteria: * egyptian physiotherapists with non-specific low back pain. * physiotherapy graduate who worked for at least two years (khairy et al.,2019). * age range from 25 to 40 years old (pellissier et al., 2023). * male and female. * normal bmi ranges between 18.5:24.9 kg/m2. exclusion criteria: * physiotherapists outside the target range age an bmi. * students of physical therapy or physiotherapists who worked for less than two years. * physiotherapists who had lumbar spine surgery. * physiotherapists who had history sever lumbar problem spondylolisthesis, tumor, fracture. * physiotherapists who suffers from vertigo.

Keywords: mechanical awareness core stability exercises
urinary and anal incontinence in tunisian women

Conditions: Woman

Summary: the publications on prevalence and risk factors of urinary and anal incontinence in women were performed mainly in europe and america. consequently, result extrapolation to tunisian population may not be a good practice which justifies this study and demonstrates its importance.

a cross-sectional study will be conducted among female doctors and nurses randomly selected from 3 large hospitals in the center of tunisia. the prevalence of urinary incontinence and anal incontinence will be measured using validated questionnaires.

Eligibility criteria:
inclusion criteria: * professional seniority in the current service over than 6 months * subject has given his consent exclusion criteria: * resident * intern * an ongoing pregnancy * a recent birth (less than 6 months) * a psychiatric disease * an acute or chronic kidney disease * neurological disease

Keywords: prevalence urinary incontinence anal incontinence risk factors women
ncontactsurgical numeris-af tethered coagulation system for treatment of persistent & lsp af

Conditions: Atrial Fibrillation

Summary: this is a multi center, non-randomized, prospective, open label, clinical trial evaluating the safety and efficacy of the ncontact surgical numeris-af tethered coagulation system when used to treat patients with persistent and longstanding persistent af during concomitant cardiac surgery.

the purpose of this study is to determine the safety and efficacy of the numeris-af tethered coagulation system with visitrax when used to treat persistent and longstanding persistent atrial fibrillation(af)during concomitant cardiac surgery.

Eligibility criteria:
inclusion criteria: * age \> 18 years; \< 80 years * left atrium =\< 6.0 cm * documented persistent or longstanding persistent af * history of af =\< 10 years * scheduled for a concomitant cardiac procedure * coronary bypass surgery (cabg) * mitral valve repair/replacement * aortic valve replacement * asd repair * tricuspid valve repair/replacement * myxoma * any combination of the above procedures * provided written informed consent exclusion criteria: * left atrial size \> 6.0 cm (pre-op tte - parasternal 4 chamber view) * history of af \> 10 years * left ventricular ejection fraction \< 30% * pregnant or planning to become pregnant during study * co-morbid medical conditions that limit one year life expectancy * history of coagulopathy * patients who are contraindicated for anticoagulants(heparin, warfarin etc.) * previous cardiac surgery * history of pericarditis * previous cerebrovascular accident (cva) * patients who have active infection or sepsis * patients who have uncorrected reversible cause(s) of af such as hyperthyroidism and electrolyte imbalance * patients who are being treated for ventricular arrhythmias * patients who have had a previous catheter ablation for af (does not include ablation for aflutter) * current participation in another clinical investigation of a medical device or a drug, or recent participation in such a study within 30 days prior to study enrollment. * not competent to legally represent him or herself (e.g., requires a guardian or caretaker as a legal representative).

Keywords: af atrial fibrillation ablation surgical ablation afib coagulation rf epicardial arrhythmias
effect of exercise and manuel therapy methods on pain, posture, daily living in people with cervical pathologies

Conditions: Musculoskeletal Disorder of the Neck

Summary: the aim of the study is to determine the effect of exercise and two different manual therapy methods on pain, quality of life and posture in people with neck pain.

deep friction massage will use on cervical regions in first group, muscle energy technic will use second group and cervical stabilization exercise will use as an third group. for all groups, pain intensity, quality of life and posture will assess.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cervical disorder (for example; chronic neck pain, cervical disc herniation) * must have pain at least three months. exclusion criteria: * history of structural scoliosis * history of surgery * history of metabolic, neurologic and metastatic diseases.

Keywords: neck pain physiotherapy rehabilitation
comparison of lipophilic versus hydrophilic statins on patients with heart failure

Conditions: Heart Failure

Summary: there is a controversy whether statins are beneficial in patients with heart failure or not. trials in which lipophilic statins have been used revealed positive results, unlike major studies where hydrophilic statins were administered. this trial is designed to compare the effects of lipophilic versus hydrophilic statin use in patients with heart failure.


Eligibility criteria:
inclusion criteria: * older than 18 years (of both sexes) * diagnosed with stable chronic heart failure nyha class ii-iii * ejection fraction \< 40 % as assessed by 2d echocardiography * who have been optimized on guideline directed treatment for heart failure for at least a month prior to enrolling. exclusion criteria: * known hypersensitivity to statin * treatment with statins during the past month prior to study. * serum creatinine \> 3 mg/dl * significant liver disease: liver enzymes 2.5 folds the upper normal limit * malignancy * pregnancy or lactation

Keywords: statin hydrophilic lipophilic