Kornimate/medical-research-clean huggingface dataset:
sequential treatment of extra-corporeal shock wave combined with autologous bone marrow mesenchymal stem cells on patients with ischemic heart disease : the s-cure study

Conditions: Ischemic Heart Disease

Summary: this study is designed to evaluate the efficacy, safety and tolerability of autologous bone marrow derived mesenchymal stem cells compared to placebo (sham operation) when administered via percutaneous coronary infusion to patients with ischemic heart disease, who are screened by d-spect and have pretreated with 3-month cardiac shock wave therapy.


Eligibility criteria:
inclusion criteria: 1. males and non-pregnant, non-lactating females; 2. chronic ischemic heart failure, previous anterior myocardial infarction \> 3months; 3. viable myocardium is detected by d-spect; 4. lvef \< 50% measured by echocardiography or nyha ii-iv; 5. no planed reasonable revascularization procedures; 6. at least 30 days standard medical therapy for heart failure before screening; 7. worsening heart failure within 6 months or have a nt-probnp ≥1000 pg/ml or bnp ≥200 pg/ml within 30 days of screening (including screening); or have a 6-minute walk test (6mwt) distance of ≤425 meters at screening; 8. written informed consent. exclusion criteria: 1. ventricular thrombus; 2. myocardial infarction, tia or stroke \< 3 months; 3. crt/crt-d implantation, heart transplantation, cardiomyoplasty, left ventricular reduction surgery, heart failure-related device interventions, or cardiac shunt implantation; 4. active infection or fever; 5. chronic inflammatory disease; 6. hiv infection or active hepatitis; 7. hemoglobin a1c (hba1c) ≥ 9% at screening; 8. body mass index (bmi) ≥ 40 kg/m2 at screening; 9. chronic kidney disease (ckd) requiring dialysis (stage 5) or estimated creatinine clearance \< 30 ml/min/1.73㎡ at screening; 10. allergies to any equine, porcine, or bovine products; 11. abnormal laboratory values at screening：platelets \ 3 times the upper limit of normal (uln); 12. pregnancy; 13. mental retardation; 14. participation in other clinical study \< 1 month.

Keywords: stem cells, ischemic heart disease.
detecting infections rapidly and easily for candidemia trial (direct)

Conditions: Candidemia

Summary: the purpose of this study is to assure the uniform collection, handling, storage and transport of patient whole blood specimens and associated information to support validation of the t2 candida assay.


Eligibility criteria:
inclusion criteria: 1. subject or subject's authorized representative must be able to understand, read and sign the study specific informed consent form after the nature of the study has been fully explained to them. 2. for group a, * males and females 18 - 95 years of age. * subject is confirmed to have fungemia as evidenced by a positive diagnostic blood culture and subsequent species identification. 3. for group b, * males and females 18 - 95 years of age. * subject is hospitalized with a medical problem other than fungemia, or is being treated as an outpatient for some non-infection-related condition, and * subject is confirmed to not have fungemia as evidenced by diagnostic blood culture and subsequent species identification. exclusion criteria: 1. use of any novel (i.e. not commercially available) drug compound within 30 days prior to the collection of t2 blood specimens. 2. subject has other co-morbid condition(s) that, in the opinion of the investigator, could limit the subject's ability to participate in the study or impact the scientific integrity of the study.

Keywords: candida diagnostic assay blood culture sepsis t2 magnetic relaxation
exercise during and after neoadjuvant rectal cancer treatment

Conditions: Rectal Cancer

Summary: this study is designed to investigate if aerobic exercise during and after neoadjuvant chemoradiotherapy (nacrt) can improve outcomes for rectal cancer patients.

the exert trial is a single-center, prospective, two-armed, phase ii randomized controlled trial designed to test the preliminary efficacy of exercise training in this clinical setting and to further evaluate its feasibility and safety. participants will be 60 rectal cancer patients scheduled to receive long-course nacrt followed by total mesorectal excision. participants will be randomly assigned to exercise training or usual care. participants in the exercise training group will be asked to complete three supervised, high-intensity interval training sessions/week during nacrt and ≥ 150 min/week of unsupervised, moderate-to-vigorous-intensity, continuous exercise training after nacrt prior to surgery. participants in the usual care group will be asked not to increase their exercise from baseline. assessments will be completed pre nacrt, post nacrt, and pre surgery. the primary endpoint will be cardiorespiratory fitness (vo2 peak) at the post-nacrt time point assessed by a graded exercise test. secondary endpoints will include functional fitness, quality of life, and symptom management. exploratory clinical endpoints will include treatment toxicities, treatment completion, treatment response, and surgical complications.

Eligibility criteria:
inclusion criteria: * all patients scheduled to receive long-course (5-6 weeks) of nacrt followed by total mesorectal excision exclusion criteria: * unable to consent * unable to perform aerobic exercise * intention to engage in a structured exercise program during nacrt and/or after nacrt and prior to surgery

Keywords: exercise cancer symptom management quality of life presurgical chemoradiotherapy physical fitness
computed tomography enterography (cte) versus capsule endoscopy for overt, obscure gastrointestinal (gi) bleeding

Conditions: Recurrent Gastrointestinal Bleeding

Summary: up to 5% of patients with recurrent gastrointestinal (gi) bleeding remain undiagnosed by upper endoscopy and colonoscopy, the presumed source of bleeding in these patients being the small intestine. these patients fall under the category of "obscure gastrointestinal bleeding," and frequently require an extensive diagnostic work-up. obscure gastrointestinal bleeding (ogib) refers to bleeding undiagnosed by upper endoscopy and colonoscopy. in 40-70% of cases of ogib, a bleeding lesion is localizable to the small bowel. in ogib, capsule endoscopy (ce) has a diagnostic yield of 40-80%, and has demonstrated diagnostic superiority to push enteroscopy, barium studies, angiography, ct angiography, and routine abdominal ct scan. when ce is non-diagnostic, however, the subsequent diagnostic algorithm is not well-defined. there is currently no established role for cross-sectional imaging for this indication. ct enterography (cte) combines the spatial and temporal resolution of ct with an orally administered neutral enteric contrast material that permits detailed visualization of the small bowel. unlike other imaging modalities such as nuclear medicine techniques and catheter angiography, ct is less labor-intensive, more readily available, and provides precise anatomic localization. a novel ogib-protocol available at brigham and women's hospital for cte utilizes a dual-phase, dual energy technique that obtains images at two time points to better identify active bleeding in the mesentery. we, the investigators, plan to prospectively study an algorithm that employs cte and compare to capsule endoscopy to investigate the effectiveness of both modalities and to evaluate the potential role of cte in ogib. the goal of our study is to determine observationally the contribution of both ce and the new protocol for cte to the evaluation and management of overt obscure gi bleeding and accordingly revise the clinical algorithm. we hypothesize that cte will be as or more effective than ce at identifying culprit lesions in overt, obscure gastrointestinal bleeding.


Eligibility criteria:
inclusion criteria: * patients presenting with signs and symptoms of "overt, obscure gi bleeding" including hematemesis, melena, and hematochezia within the past 14 days with negative endoscopic evaluation (including upper endoscopy for hematemesis, and both upper and lower endoscopy for hematochezia) despite clinical evidence of gi bleeding. exclusion criteria: * known renal insufficiency (or blood creat \>1.5 or estimated glomerular filtration rate \[egfr\]\<60) * allergy to iodinated intravenous (iv) contrast media * swallowing difficulties * known small bowel strictures * suspected bowel obstruction * under the age of 18 * unable to give consent * currently pregnant

Keywords: overt obscure gastrointestinal bleeding hemorrhage
reducing pain with focused music listening

Conditions: Pain

Summary: pain-reducing effects of music listening are well-established, but the effects are small and their clinical relevance questionable. recent theoretical advances, however, have proposed that synchronizing to music, such as clapping, tapping or dancing, has evolutionarily important social effects that are associated with activation of the endogenous opioid system (eos; which supports both analgesia and social bonding). thus, active sensorimotor synchronization to music could have stronger analgesic effects than simply listening to music. however, to the best of the investigators' knowledge, the hypothesis of an eos activation by sensorimotor synchronization to music has never been investigated. accordingly, the investigators set up a test with the premise that if sensorimotor synchronization to music indeed activates the eos, then it should have larger pain-reducing effects than simply listening to music. using pressure algometry to the fingernails, specific amounts of pain were delivered to healthy adults either during music listening or silence, while either performing an active tapping task or a passive control task. as the dependent variable, perceived pain was rated on a scale ranging from 1 to 9 (1 = very little, 5 = medium, 9 = very strong). in addition, to pain ratings, participants provided ratings of their emotional state in terms of pleasantness as well as arousal, and then rated their familiarity with the music (also on scales ranging from 1 to 9). emotion ratings were obtained to explore whether the mechanisms driving pain-reducing effects of sensorimotor synchronization to music include emotion. at the end of the experiment, participants also rated their preference for the music on a scale ranging from 1 to 9 (see method). familiarity and preference ratings were obtained to elucidate possible contributions of these factors on pain reduction.


Eligibility criteria:
inclusion criteria: * 18 years or older * healthy exclusion criteria: * history of a psychiatric or neurological disease * history of substance dependence * use of any prescription drugs * hearing impairment * musical anhedonia
the clinical outcomes and prediction of thermal ablation for low-risk papillary thyroid carcinoma

Conditions: Papillary Thyroid Cancer

Summary: 1. to evaluate the clinical outcomes of ultrasound-guided thermal ablation and thyroid surgery for the treatment of papillary thyroid carcinoma; 2. to develop and validate a artificial intelligence model to predict the outcomes of ultrasound-guided thermal ablation in the treatment of papillary thyroid carcinoma;


Eligibility criteria:
inclusion criteria: 1. patients age between 18 and 80 year old, both sex 2. papillary thyroid carcinoma confirmed by core-needle biopsy or fine-needle aspiration 3. the largest diameter ≤2.0 cm 4. no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, nech and chest ct 5. follow-up period ≥12 months, exclusion criteria: 1. patients with convincing evidence of aggressive papillary thyroid carcinoma or other type of thyroid cancer by biopsy 2. history of neck radiation 3. history of thyroid surgery 4. coagulation disorder 5. serious heart, respiratory, liver, or renal failure 6. dysfunction of the vocal cord on the opposite side
nurse counseling for physical activity in primary care patients

Conditions: Chronic Disease; Exercise

Summary: many elderly primary care patients are at high risk for health complications and functional impairment due to low levels of physical activity. previous trials of counseling of elderly patients in primary care clinics have not demonstrated lasting physical activity change and have not evaluated fitness changes associated with any increased activity.

background: many elderly primary care patients are at high risk for health complications and functional impairment due to low levels of physical activity. previous trials of counseling of elderly patients in primary care clinics have not demonstrated lasting physical activity change and have not evaluated fitness changes associated with any increased activity. objectives: the primary objective was to determine if nurse telephone counseling could assist 60 to 80 year old va primary care patients to establish and maintain a regular walking program. methods: in this randomized clinical trial, 60-80 year old patients were referred to a walking program by primary care providers. all participants received individualized counseling by the nurse and, over the next year, one of three follow-up interventions: 1) 20 calls initiated by the nurse; 2) ten calls initiated by the nurse and ten initiated by an automated telephone message delivery system; or 3) no follow-up calls. all kept walking diaries and mailed these in to a data collector blinded to intervention group. follow-up research visits were scheduled at six and 12 months. self-reported walking, the primary outcome measure, was assessed from the walking diaries and validated by reports of significant others and accelerometer data. improvement in fitness was assessed at 12 months with a standardized six minute walking test. tinetti mobility scores, body mass index, and body girths were also assessed. several quality of life measures were also administered. status: complete.

Eligibility criteria:
inclusion criteria: 60-80 year old patients referred to a walking program by a primary care provider. exclusion criteria:

Keywords: telephone
extension from weekly to once every other week darbepoetin alfa administration in subjects with chronic kidney disease receiving dialysis

Conditions: Chronic Kidney Disease

Summary: the purpose of this study is to assess the proportion of subjects sucessfully achieving a mean hemoglobin greater than or equal to 11 g/dl during the evaluation period following extension from weekly (qw) to once every other week (q2w) darbepoetin alfa administraion.


Eligibility criteria:
inclusion criteria: * receiving dialysis for 3 months or more before enrollment. * the mean of 2 screening hb values taken at least 7 days appart must be greater than or equal to 11g/dl and less than or equal to 13.0 g/dl * receiving stable qw darbepoetin alfa doses for at least 6 weeks before enrollment * adequate iron stores (serum ferritin equal to or greater than 100 ug/l exclusion criteria: * uncontrolled hypertension * prior history of cardiovascular incidents 12 weeks prior to enrollment * other hematological disorders * upper or lower gi bleed within the prior 6 months

Keywords: dialysis anaemia
comparing effect of hyaluronic acid and lipid coated carbomer gel on dry eyes after phacoemulsification in dp

Conditions: Dry Eye

Summary: in this study we compare the curative effect of two lubricants hylorunic acid and visol gel on dry eyes after phacoemulsification in diabetic patients. we check the tear film before operation and check post operate after 2nd week and 4th week of surgery. its a hospital based study .


Eligibility criteria:
inclusion criteria: * patients who have acute dry eye condition before phacoemulsification cataract surgery. exclusion criteria: * patients who have chronic dry eye condition before phacoemulsification cataract surgery.
establishment and verification of pancreatic volume formula based on imaging

Conditions: Healthy People; Chronic Pancreatitis; Acute Pancreatitis

Summary: this study intends to construct the linear relationship between pancreatic volume and individual attributes (height, weight, width of anterior superior iliac spine, etc.), and to establish and verify the formula of pancreatic volume.

the volume of pancreas in healthy individuals changes with age. the pancreatic volume gradually increases from birth to 20 years old. there is a plateau period from 20 to 60 years old, and the volume gradually decreases after 60 years old. with the development of imaging technology, pancreatic volume can be measured by computer tomography and magnetic resonance imaging. whether it is pancreatic atrophy after chronic pancreatitis or pancreatic edema after acute pancreatitis, the pathological changes of pancreatic parenchyma may lead to changes in pancreatic volume. many studies have confirmed that pancreatic volume can be used to evaluate the course of pancreatic related diseases such as diabetes and acute pancreatitis. therefore, the establishment of accurate and convenient pancreatic volume formula can help to estimate the initial pancreatic volume of patients. this study is helpful to evaluate the clinical stage, severity and prognosis of pancreatic related diseases.

Eligibility criteria:
inclusion criteria (meet 1 or 2 or 3): * healthy individuals (excluding pancreatic related diseases, such as acute and chronic pancreatitis, pancreatic trauma, pancreatic tumor, peripancreatic lesions, diabetes and other diseases that may affect the volume of the pancreas); * patients with chronic pancreatitis; * patients with acute pancreatitis within 144 hours after the onset of typical symptoms (severe persistent epigastric pain). exclusion criteria: * suspected to have malignant tumors; * history of pancreas related surgery or minimally invasive treatment (such as pancreaticoduodenectomy, ercp, etc.); * acute exacerbation of chronic pancreatitis; * pregnant or breastfeeding women; * patients who refused to participate in the study.

Keywords: magnetic resonance imaging pancreatic volume
efficacy and safety of clino-san on vaginal dryness of breast cancer patients

Conditions: Breast Cancer; Vaginal Atrophy

Summary: 1. although after treatment for breast cancer such as chemotherapy or hormonal therapy, urogenital atrophy is common, the patients are seldomly treated for several reasons. management of this problem is important for improving quality of life. 2. "clino-san" is a kind of vaginal lubricant with ph 5 which is similar ph of premenopausal vaginal discharge. after randomization of patients, they are treated with clino-san or placebo 3 times/week for 12 weeks. 3. we check the vaginal symptoms, vag dryness severity score, and ultrasonography at baseline, 4, 8, and 12 weeks of treatment.


Eligibility criteria:
inclusion criteria: * breast cancer patients * who are treated with chemotherapy or hormonal therapy * who experience no menstruation after the previous therapy * who complain of vaginal dryness exclusion criteria: * other cancer patients * other severe disease * poor compliance

Keywords: chemotherapy hormonal therapy urogenital atrophy
post-operative pain management in patients undergoing hullax valgus surgery

Conditions: Pain

Summary: the purpose of this study is to investigate the efficacy and cost analysis of intravenous fentanyl combined with either local anesthesia infiltration or peroneal nerves block in patients with hallux valgus undergoing orthopedic corrective surgery and compared with patients without local anesthetics administration perioperatively.


Eligibility criteria:
inclusion criteria: 1. patients with american society of anesthesiologists physical status i-iii 2. aged 20-65 years 3. requiring local anesthesia and pca use 4. no severe cardiac or pulmonary diseases 5. bmi \<35 kg/m2 exclusion criteria: 1. bmi ≧35 kg/m2 2. age \> 65years 3. allergy to opioid or local anesthetics

Keywords: pca,nerve block,hullax valgus
which trocar access site should we use in laparoscopic appendectomy?

Conditions: Pain

Summary: open appendectomy has been used in the treatment of appendicitis, which is among the most common emergency pathologies worldwide, since the end of the 19th century. in the 20th century, laparoscopic appendectomy came to the fore and the frequency of use increased gradually. despite the frequency of laparoscopic appendectomy, there is no consensus on the best way to perform each procedural step. one of these steps is the trocar entry areas. in this study, investigator's aim is to compare the trocar entry areas, which are various reports in the literature, and to find the localization with the optimal usage area. 140 patients who underwent laparoscopic appendectomy between 2021-2022 were randomized into four groups and included in the study. demographic data, peroperative findings, complications, length of stay and post-operative vas values of the patients were evaluated.


Eligibility criteria:
inclusion criteria: * patients who underwent laparoscopic appendectomy exclusion criteria: patients who underwent open surgery and did not want to be involved in the study process

Keywords: laparoscopy minimally invasive surgery appendicitis colorectal
home-based automated therapy of arm function after stroke via tele-rehabilitation

Conditions: Stroke

Summary: constraint-induced movement therapy, also known as ci therapy, is an approach to physical rehabilitation derived from basic behavioral and neuroscience research. it has been shown to be efficacious for rehabilitating use of the more-affected arm in individuals more than one year after stroke with mild to moderate motor impairment. the first component of the therapy is intensive training in use of the more-affected arm on functional tasks for 3 hours daily for 10 consecutive weekdays. the second is wearing a protective safety mitt on the less-affected hand for all waking hours of the approximately 2-week treatment period that it is safe to do so. the purpose of the mitt is to discourage use of the less-affected arm. the third is a group of behavioral techniques designed to transfer gains from the treatment setting to the real world, which takes a therapist, on average, 30 minutes to implement on each treatment day. the purpose of this project is to develop and test a method for automating the delivery of this efficacious treatment in a way that the therapy can be provided in stroke patients' homes. after developing an automated ci therapy workstation that has tele-health capabilities, the investigators will conduct a randomized controlled trial to evaluate whether ci therapy delivered in the home using this workstation with remote supervision by a therapist via an internet-based audiovisual link provides outcomes that are just as good as ci therapy delivered by a "live" therapist.


Eligibility criteria:
inclusion criteria: * more than 1 year after stroke * some ability to voluntarily open fingers on more affected side of body * some ability to voluntarily raise wrist on more affected side of body * ability to stand independently for two minutes * ability to transfer from sit to stand independently exclusion criteria: * serious, concurrent medical conditions including frailty * excessive spasticity (high muscle tone) in more affected arm * impairment in thinking that makes compliance with study activities difficult

Keywords: stroke chronic arm rehabilitation tele-health